title: Allergenicity of vertebrate tropomyosins: Challenging an immunological dogma.
abstract: With the exception of tilapia tropomyosin, other anecdotic reports of tropomyosin recognition of vertebrate origin are generally not accompanied by clinical significance and a dogmatic idea is generally accepted about the inexistence of allergenicity of vertebrate tropomyosins, based mainly on sequence similarity evaluations with human tropomyosins. Recently, a specific work-up of a tropomyosin sensitised patient with seafood allergy, demonstrated that the IgE-recognition of tropomyosin from different fish species can be clinically relevant. We hypothesise that some vertebrate tropomyosins could be relevant allergens. The hypothesis is based on the molecular evolution of the proteins and it was tested by in silico methods. Fish, which are primitive vertebrates, could have tropomyosins similar to those of invertebrates. If the hypothesis is confirmed, tropomyosin should be included in different allergy diagnosis tools to improve the medical protocols and management of patients with digestive or cutaneous symptoms after fish intake.
authors: Departamento de Parasitología, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain. Electronic address: quintas_copo@hotmail.com.
authors: J
authors: J
authors: González-Fernández
authors: Servicio de Alergia, Instituto de Investigación Sanitaria-Hospital Universitario de La Princesa, 28006 Madrid, Spain.
authors: A
authors: A
authors: Daschner
authors: Departamento de Parasitología, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain.
authors: C
authors: C
authors: Cuéllar
mesh_terms: D000485:Allergens / Q000276:immunology*; D000818:Animals; D005512:Food Hypersensitivity / Q000276:immunology*; D006801:Humans; D014335:Tropomyosin / Q000276:immunology*; D014714:Vertebrates
chemical_list: D000485:Allergens; D014335:Tropomyosin
keywords: Cross-reactivity; Evolution; Fish; IgE; Panallergen; Tropomyosin