title: [Primary mediastinal large B-cell lymphoma in women: about five cases].
abstract: Primary mediastinal large B-cell lymphoma (PMBL) is a lymphoma occurring in the anterior mediastinum starting from the cells B of the thymique medullary zone. This is a rare entity characterized by epidemiological, clinical and evolutionary peculiarities as well as by pathological and immunohistochemical peculiarities. We report a case series of 5 patients with diagnosed PMBL hospitalized in Pulmonology Department of Ibn Sina Hospital between January 2012 and May 2016. The average age was 34 years, the median of consultation time was 2 months. Reported symptoms were dyspnea, chest pain, dry cough; two patients suffered from superior vena cava syndrome. LDH level was high in 4 patients. Thoracic imaging showed an anterior mediastinal tissue processing in 5 patients. Histological diagnosis was based on ultrasound-guided transparietal puncture biopsy in 5 patients. The contribution of immunohistochemistry was decisive in all cases. Patients were sent to the National Institute of Oncology for therapeutic management. PMBL prognosis is reserved, it most commonly occurs in young women, which increases the need of aggressive therapy to improve survival rate.
authors: Service de Pneumologie, Hôpital Ibn Sina, CHU Rabat, Maroc.
authors: Safaa
authors: S
authors: Ouassou
authors: Service de Pneumologie, Hôpital Ibn Sina, CHU Rabat, Maroc.
authors: Laila
authors: L
authors: Herrak
authors: Service de Pneumologie, Hôpital Ibn Sina, CHU Rabat, Maroc.
authors: Leila
authors: L
authors: Achachi
authors: Laboratoire d'Anatomo-pathologie, Hôpital Ibn Sina, CHU Rabat, Maroc.
authors: Fatima
authors: F
authors: Nachite
authors: Laboratoire d'Anatomo-pathologie, Hôpital Ibn Sina, CHU Rabat, Maroc.
authors: Kaoutar
authors: K
authors: Znati
authors: Service de Pneumologie, Hôpital Ibn Sina, CHU Rabat, Maroc.
authors: Mustapha El
authors: ME
authors: Ftouh
mesh_terms: D000328:Adult; D002637:Chest Pain / Q000209:etiology; D003371:Cough / Q000209:etiology; D004417:Dyspnea / Q000209:etiology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy; D008479:Mediastinal Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy; D011379:Prognosis; D013479:Superior Vena Cava Syndrome / Q000209:etiology
keywords: Primary mediastinal large B-cell lymphoma; mediastinal lymphoma; mediastinum; non-Hodgkin lymphoma; woman