title: Antiulcer Activity of Ethanolic Extract ofSalvadora indica (W.) Leaves onAlbinoRats.
abstract: BACKGROUND
  Ulcer can be developed inside the inner lining of the stomach (gastric ulcer) or the small intestine (duodenal ulcer). Both the ulcers are also cumulatively referred as peptic ulcers. It affects nearly 10% of world population.
  
  
  OBJECTIVE
  To investigate the antiulcer activity of ethanolic extract ofSalvadora indicaW. leaves (ESIL) on albino rats.
  
  
  METHODS
  The present study was carried by pylorus ligation, ethanol and cysteamine induced ulcer models in albino rats. The antiulcer activity of ESIL (150, 300 and 600 mg/kg p.o. for 7 days) was compared with standard drugs (Ranitidine). In pyloric ligation induced ulcer model, the studied parameters were gastric volume, pH, total acidity, free acidity, and ulcer index whereas in ethanol and cysteamine induced ulcer model, the ulcer index was determined for severity of ulcers. The parameters studied were ulcer index, gastric juice volume, pH, free acidity and total acidity.
  
  
  RESULTS
  In pyloric ligation model; the volume of gastric content, total/free acidity and pepsin activity was significantly decreased at p<0.05 and p<0.01 and pH of the gastric juice was significantly increased at p<0.05 and p<0.01 in ESIL treated groups as compared to control group. All the doses of ESIL showed dose dependent antiulcer effect as well as significant (p<0.05 and p<0.01) reduction in the ulcer index as compared to control group in all the experimental models.
  
  
  CONCLUSIONS
  The results of the study indicate that the ESIL have better potential against ulcer which supports the traditional claims in folklore medicine.
authors: Assistant Professor, Department of Pharmaceutical Chemistry, Sri Sivani College of Pharmacy , Srikakulam, Andhra Pradesh, India .
authors: Saroj Kumar
authors: SK
authors: Sahoo
authors: Assistant Professor, Department of Pharmacology, MKCG Medical College & Hospital , Berhampur, Odisha, India .
authors: Himanshu Bhusan
authors: HB
authors: Sahoo
authors: Assistant Professor, Department of Pharmacology, Sri Sivani College of Pharmacy , Srikakulam, Andhra Pradesh, India .
authors: D
authors: D
authors: Priyadarshini
authors: Assistant Professor, Department of Pharmaceutical Analysis, Sri Sivani College of Pharmacy , Srikakulam, Andhra Pradesh, India .
authors: G
authors: G
authors: Soundarya
authors: Assistant Professor, Department of Pharmaceutics, Sri Sivani College of Pharmacy , Srikakulam, Andhra Pradesh, India .
authors: Ch Kishore
authors: CK
authors: Kumar
authors: Assistant Professor, Department of Pharmacology, Sri Sivani College of Pharmacy , Srikakulam, Andhra Pradesh, India .
authors: K Usha
authors: KU
authors: Rani
keywords: Antiulcer effect; Cysteamine; Ethanol; Pylorus ligation; Ulcer index