title: Dual Tasking for the Differentiation between Depression and Mild Cognitive Impairment.
abstract: Differentiation of mild cognitive impairment from depression in elderly adults is a clinically relevant issue which is not sufficiently solved. Gait and dual task (DT) parameters may have the potential to complement current diagnostic work-up, as both dementia and depression are associated with changes of gait and DT parameters.
  
  
  METHODS
  Seven hundred and four participants of the TREND study (Tübinger evaluation of Risk factors for Early detection of NeuroDegeneration) aged 50-80 years were assessed using the Consortium to Establish a Registry for Alzheimer's Disease Plus test battery for testing cognition and Beck's Depression Inventory for evaluation of depression. Based on these results, four groups were defined: acute depressed (N= 53), cognitively mildly impaired (N= 97), acute depressed, and cognitively mildly impaired (N= 15), and controls (N= 536). Participants underwent a 20 m walk and checking boxes task under single (ST) and DT conditions. ST and DT performance and dual task costs (DTC) were calculated. Due to the typical age of increasing incidence of depressive and also cognitive symptoms, the 7th decade was calculated separately.
  
  
  RESULTS
  ST speeds of gait and checking boxes, DT walking speed, and walking DTC were significantly different between groups. Healthy controls were the fastest in all paradigms and cognitively mildly impaired had higher DTC than depressed individuals. Additionally, we constructed a multivariate predictive model differentiating the groups on a single-subject level.
  
  
  CONCLUSIONS
  DT parameters are simply and comfortably measureable, and DTC can easily be determined. The combination of these parameters allows a differentiation of depressed and cognitively mildly impaired elderly adults.
authors: Department of Psychiatry and Psychotherapy, University Hospital TuebingenTuebingen, Germany; Center for Geriatric Medicine, University Hospital of TuebingenTuebingen, Germany.
authors: Florian G
authors: FG
authors: Metzger
authors: Department of Neurodegenerative Diseases, Center of Neurology and Hertie Institute for Clinical Brain Research, University Hospital of TuebingenTuebingen, Germany; German Center for Neurodegenerative Diseases (DZNE), University Hospital of TuebingenTuebingen, Germany.
authors: Markus A
authors: MA
authors: Hobert
authors: Department of Psychiatry and Psychotherapy, University Hospital Tuebingen Tuebingen, Germany.
authors: Ann-Christine
authors: AC
authors: Ehlis
authors: Department of Neurodegenerative Diseases, Center of Neurology and Hertie Institute for Clinical Brain Research, University Hospital of Tuebingen Tuebingen, Germany.
authors: Sandra E
authors: SE
authors: Hasmann
authors: Institute of Psychology, Johann Wolfgang Goethe University of Frankfurt Frankfurt, Germany.
authors: Tim
authors: T
authors: Hahn
authors: Department of Psychiatry and Psychotherapy, University Hospital TuebingenTuebingen, Germany; Center for Geriatric Medicine, University Hospital of TuebingenTuebingen, Germany.
authors: Gerhard W
authors: GW
authors: Eschweiler
authors: Department of Neurodegenerative Diseases, Center of Neurology and Hertie Institute for Clinical Brain Research, University Hospital of TuebingenTuebingen, Germany; German Center for Neurodegenerative Diseases (DZNE), University Hospital of TuebingenTuebingen, Germany; Department of Neurology, University Hospital of Schleswig-Holstein Campus KielKiel, Germany.
authors: Daniela
authors: D
authors: Berg
authors: Department of Psychiatry and Psychotherapy, University Hospital Tuebingen Tuebingen, Germany.
authors: Andreas J
authors: AJ
authors: Fallgatter
authors: Center for Geriatric Medicine, University Hospital of TuebingenTuebingen, Germany; Department of Neurodegenerative Diseases, Center of Neurology and Hertie Institute for Clinical Brain Research, University Hospital of TuebingenTuebingen, Germany; German Center for Neurodegenerative Diseases (DZNE), University Hospital of TuebingenTuebingen, Germany.
authors: Walter
authors: W
authors: Maetzler
keywords: depression; dual-task costs; gait speed; mild cognitive impairment; working memory