title: Synthesis of new Schiff bases bearing 1,2,4-triazole, thiazolidine and chloroazetidine moieties and their pharmacological evaluation.
abstract: New compounds based on oxindole moiety were synthesized via the reaction of 5-substitued isatins 1a-e with different nucleophiles such as benzidine, 3,3'-dimethoxybenzidine 2a,b and 2,6-diaminopyridine 3 to afford three different classes of bis-Schiff bases 4a-e, 5a-e and 6a-e, respectively. The structures of the new compounds were elucidated on the basis of their FTIR,1H NMR,13C NMR, GC/MS spectral data and elemental analysis. The in vitro antimicrobial activity of the new compounds was evaluated using a broth dilution technique in terms of minimal inhibitory concentration (MIC) against four bacterial and two fungal pathogens and anticancer activities against HELA cervix. The revealed data showed that compound 9d has excellent activity against Gram + ve and Gram -ve bacteria, and compounds 11b presented promising anticancer activity against HELA cervix. [Formula: see text].
authors: a Department of Chemistry, Faculty of Women , Ain Shams University , Heliopolis , Cairo , Egypt.
authors: Nadia G
authors: NG
authors: Kandile
authors: a Department of Chemistry, Faculty of Women , Ain Shams University , Heliopolis , Cairo , Egypt.
authors: Mansoura I
authors: MI
authors: Mohamed
authors: a Department of Chemistry, Faculty of Women , Ain Shams University , Heliopolis , Cairo , Egypt.
authors: Hind M
authors: HM
authors: Ismaeel
mesh_terms: D001384:Azetidines / Q000737:chemistry*; D012545:Schiff Bases / Q000138:chemical synthesis* / Q000494:pharmacology*; D053778:Thiazolidines / Q000737:chemistry*; D014230:Triazoles / Q000737:chemistry*
chemical_list: D001384:Azetidines; D012545:Schiff Bases; D053778:Thiazolidines; D014230:Triazoles; C082735:azetidine
keywords: Anticancer drugs; Schiff bases; minimal inhibitory concentration; oxindole moiety; pathagonic bacteria