title: Propeptide big-endothelin, N-terminal-pro brain natriuretic peptide and mortality. The Ludwigshafen risk and cardiovascular health (LURIC) study.
abstract: BACKGROUND
  The endothelin system (Big-ET-1) is a key regulator in cardiovascular (CV) disease and congestive heart failure (CHF).
  
  
  OBJECTIVE
  We have examined the incremental value of Big-ET-1 in predicting total and CV mortality next to the well-established CV risk marker N-Terminal Pro-B-Type Natriuretic Peptide (NT-proBNP).
  
  
  METHODS
  Big-ET-1 and NT-proBNP were determined in 2829 participants referred for coronary angiography (follow-up 9.9 years).
  
  
  RESULTS
  Big-ET-1 is an independent predictor of total, CV mortality and death due to CHF.
  
  
  CONCLUSIONS
  The conjunct use of Big-ET-1 and NT-proBNP improves the risk stratification of patients with intermediate to high risk of CV death and CHF.
  
  
  CONCLUSIONS
  Big-ET-1improves risk stratification in patients referred for coronary angiography.
authors: a Vth Department of Medicine, Medical Faculty Mannheim , University of Heidelberg , Mannheim , Germany.
authors: Ingrid
authors: I
authors: Gergei
authors: a Vth Department of Medicine, Medical Faculty Mannheim , University of Heidelberg , Mannheim , Germany.
authors: Bernhard K
authors: BK
authors: Krämer
authors: b Clinical Institute of Medical and Chemical Laboratory Diagnostics , Medical University of Graz , Graz , Austria.
authors: Hubert
authors: H
authors: Scharnagl
authors: b Clinical Institute of Medical and Chemical Laboratory Diagnostics , Medical University of Graz , Graz , Austria.
authors: Tatjana
authors: T
authors: Stojakovic
authors: a Vth Department of Medicine, Medical Faculty Mannheim , University of Heidelberg , Mannheim , Germany.|b Clinical Institute of Medical and Chemical Laboratory Diagnostics , Medical University of Graz , Graz , Austria.|c Synlab Academy, Synlab Holding Deutschland GmbH , Mannheim and Augsburg , Germany.
authors: Winfried
authors: W
authors: März
authors: d Department of Medicine, Division of Nephrology , Johann Wolfgang Goethe-University , Frankfurt am Main , Germany.|e UMHealthcare, Frankfurt am Main , Germany.
authors: Ulrich
authors: U
authors: Mondorf
mesh_terms: D002318:Cardiovascular Diseases / Q000097:blood / Q000175:diagnosis* / Q000401:mortality; D017023:Coronary Angiography; D019332:Endothelin-1 / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D006333:Heart Failure / Q000097:blood / Q000175:diagnosis* / Q000401:mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D011237:Predictive Value of Tests; D018570:Risk Assessment
chemical_list: D019332:Endothelin-1; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain
keywords: N-terminal-pro brain natriuretic peptide; big endothelin-1; biomarker; cardiovascular mortality; congestive heart failure