title: Activated Circulating T Follicular Helper Cells Are Associated with Disease Severity in Patients with Psoriasis.
abstract: Circulating T follicular helper (cTfh) cells are known to be involved in numerous immune-mediated diseases, but their pathological role in psoriasis is less fully investigated. Herein, we aimed to identify whether cTfh cells contributed to the pathogenesis of psoriasis. The frequency and function of cTfh cells were compared between patients with psoriasis vulgaris and healthy controls, and the infiltration of Tfh cells was detected between lesional and nonlesional skin tissues of psoriasis patients. Moreover, the dynamic change of cTfh cells before and after acitretin treatment was evaluated. Our results showed both increased frequency and activation (indicated by higher expression of ICOS, PD-1, HLA-DR, and Ki-67 and increased production of IL-21, IL-17, and IFN-γ) of cTfh cells in psoriasis patients. Compared with nonlesional skin tissues of psoriasis patients, the number of infiltrated Tfh cells was significantly increased in psoriasis lesions. In addition, positive correlations between the percentage of cTfh, functional markers on cTfh cells in peripheral blood and disease severity were noted. Furthermore, the frequency of cTfh cells and the levels of cytokines secreted by cTfh cells were all significantly decreased after 1-month treatment.
authors: Clinical Institute of China-Japan Friendship Hospital, Graduate School of Peking Union Medical College, No. 2, Yinghua East Street, Chaoyang District, Beijing 100029, China; Department of Dermatology & Venerology, China-Japan Friendship Hospital, No. 2, Yinghua East Street, Chaoyang District, Beijing 100029, China.
authors: Ying
authors: Y
authors: Wang
authors: Clinical Institute of China-Japan Friendship Hospital, Graduate School of Peking Union Medical College, No. 2, Yinghua East Street, Chaoyang District, Beijing 100029, China; Department of Dermatology & Venerology, China-Japan Friendship Hospital, No. 2, Yinghua East Street, Chaoyang District, Beijing 100029, China.
authors: Lili
authors: 0000-0003-2073-4952
authors: L
authors: Wang
authors: Beijing University of Chinese Medicine, No. 11, Bei San Huan East Road, Chaoyang District, Beijing 100029, China.
authors: Haoyu
authors: H
authors: Yang
authors: Beijing University of Chinese Medicine, No. 11, Bei San Huan East Road, Chaoyang District, Beijing 100029, China.
authors: Weichang
authors: W
authors: Yuan
authors: Department of Orthopedics, Taian Chinese Medicine Hospital, No. 58, Dongyue Street, Taishan District, Taian 271000, China.
authors: Jingyi
authors: J
authors: Ren
authors: Clinical Institute of China-Japan Friendship Hospital, Graduate School of Peking Union Medical College, No. 2, Yinghua East Street, Chaoyang District, Beijing 100029, China; Department of Dermatology & Venerology, China-Japan Friendship Hospital, No. 2, Yinghua East Street, Chaoyang District, Beijing 100029, China.
authors: Yanping
authors: 0000-0003-3365-4409
authors: Y
authors: Bai
mesh_terms: D000328:Adult; D015415:Biomarkers; D016022:Case-Control Studies; D016207:Cytokines / Q000378:metabolism; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D008213:Lymphocyte Activation / Q000276:immunology*; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011565:Psoriasis / Q000175:diagnosis* / Q000276:immunology* / Q000378:metabolism; D012720:Severity of Illness Index; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology* / Q000378:metabolism
chemical_list: D015415:Biomarkers; D016207:Cytokines