title: Erythropoietin and the use of a transgenic model of erythropoietin-deficient mice.
abstract: Despite its well-known role in red blood cell production, it is now accepted that erythropoietin (Epo) has other physiological functions. Epo and its receptors are expressed in many tissues, such as the brain and heart. The presence of Epo/Epo receptors in these organs suggests other roles than those usually assigned to this protein. Thus, the aim of this review is to describe the effects of Epo deficiency on adaptation to normoxic and hypoxic environments and to suggest a key role of Epo on main physiological adaptive functions. Our original model of Epo-deficient (Epo-TAgh) mice allowed us to improve our knowledge of the possible role of Epo in O2homeostasis. The use of anemic transgenic mice revealed Epo as a crucial component of adaptation to hypoxia. Epo-TAghmice survive well in hypoxic conditions despite low hematocrit. Furthermore, Epo plays a key role in neural control of ventilatory acclimatization and response to hypoxia, in deformability of red blood cells, in cerebral and cardiac angiogenesis, and in neuro- and cardioprotection.
authors: Laboratory "Hypoxia and Lung" EA 2363, University Paris 13, Sorbonne Paris Cité, Bobigny Cedex; Laboratory of Excellence GR-Ex, Paris; Laboratory MOVE EA 6314, FSS, Poitiers University, Poitiers, France.
authors: Aurélien
authors: A
authors: Pichon
authors: Laboratory "Hypoxia and Lung" EA 2363, University Paris 13, Sorbonne Paris Cité, Bobigny Cedex; Laboratory of Excellence GR-Ex, Paris.
authors: Florine
authors: F
authors: Jeton
authors: Research Unit, College of Medicine, Princess Noura University, Riyadh, Saudi Arabia.
authors: Raja
authors: R
authors: El Hasnaoui-Saadani
authors: Laboratório Interdisciplinar de Biociências, Universidade de Brasília, Brasília, Brazil.
authors: Luciana
authors: L
authors: Hagström
authors: Unité de Biologie Intégrative des Adaptations à l'Exercice, University Paris Saclay and Genopole , University Sorbonne-Paris-Cité, Paris, France.
authors: Thierry
authors: T
authors: Launay
authors: Laboratory "Hypoxia and Lung" EA 2363, University Paris 13, Sorbonne Paris Cité, Bobigny Cedex.
authors: Michèle
authors: M
authors: Beaudry
authors: Laboratory "Hypoxia and Lung" EA 2363, University Paris 13, Sorbonne Paris Cité, Bobigny Cedex.
authors: Dominique
authors: D
authors: Marchant
authors: Laboratory "Hypoxia and Lung" EA 2363, University Paris 13, Sorbonne Paris Cité, Bobigny Cedex.
authors: Patricia
authors: P
authors: Quidu
authors: High Altitude Unit, Laboratories for Research and Development, Universidad Peruana Cayetano Heredia, Lima, Peru.
authors: Jose-Luis
authors: JL
authors: Macarlupu
authors: Laboratory "Mitochondrie, Stress Oxydant et Protection Musculaire" EA 3072, University of Strasbourg, Strasbourg, France.
authors: Fabrice
authors: F
authors: Favret
authors: Laboratory "Hypoxia and Lung" EA 2363, University Paris 13, Sorbonne Paris Cité, Bobigny Cedex; Laboratory of Excellence GR-Ex, Paris.
authors: Jean-Paul
authors: JP
authors: Richalet
authors: Laboratory "Hypoxia and Lung" EA 2363, University Paris 13, Sorbonne Paris Cité, Bobigny Cedex; Laboratory of Excellence GR-Ex, Paris.
authors: Nicolas
authors: N
authors: Voituron
keywords: Epo-TAgh mice; hypoxia; mouse model; physiological functions