title: Eomeshi NK Cells in Human Liver Are Long-Lived and Do Not Recirculate but Can Be Replenished from the Circulation.
abstract: Human liver contains an Eomeshipopulation of NK cells that is not present in the blood. In this study, we show that these cells are characterized by a molecular signature that mediates their retention in the liver. By examining liver transplants where donors and recipients are HLA mismatched, we distinguish between donor liver-derived and recipient-derived leukocytes to show that EomesloNK cells circulate freely whereas EomeshiNK cells are unable to leave the liver. Furthermore, EomeshiNK cells are retained in the liver for up to 13 y. Therefore, EomeshiNK cells are long-lived liver-resident cells. We go on to show that EomeshiNK cells can be recruited from the circulation during adult life and that circulating EomesloNK cells are able to upregulate Eomes and molecules mediating liver retention under cytokine conditions similar to those in the liver. This suggests that circulating NK cells are a precursor of their liver-resident counterparts.
authors: Division of Infection and Immunity, Institute of Immunity and Transplantation, University College London, London NW3 2PF, United Kingdom; and.
authors: Antonia O
authors: AO
authors: Cuff
authors: Department of Surgery and Interventional Science, University College London, Royal Free Hospital, London NW3 2QG, United Kingdom.
authors: Francis P
authors: 0000-0001-5016-5944
authors: FP
authors: Robertson
authors: Division of Infection and Immunity, Institute of Immunity and Transplantation, University College London, London NW3 2PF, United Kingdom; and.
authors: Kerstin A
authors: KA
authors: Stegmann
authors: Division of Infection and Immunity, Institute of Immunity and Transplantation, University College London, London NW3 2PF, United Kingdom; and.
authors: Laura J
authors: 0000-0002-4161-9462
authors: LJ
authors: Pallett
authors: Division of Infection and Immunity, Institute of Immunity and Transplantation, University College London, London NW3 2PF, United Kingdom; and.
authors: Mala K
authors: MK
authors: Maini
authors: Department of Surgery and Interventional Science, University College London, Royal Free Hospital, London NW3 2QG, United Kingdom.
authors: Brian R
authors: BR
authors: Davidson
authors: Division of Infection and Immunity, Institute of Immunity and Transplantation, University College London, London NW3 2PF, United Kingdom; and v.male@ucl.ac.uk.
authors: Victoria
authors: 0000-0001-5654-5083
authors: V
authors: Male
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007694:Killer Cells, Natural / Q000166:cytology / Q000276:immunology*; D008099:Liver / Q000276:immunology* / Q000473:pathology; D016031:Liver Transplantation; D008297:Male; D020825:T-Box Domain Proteins / Q000276:immunology*; D013997:Time Factors; D014019:Tissue Donors; D015854:Up-Regulation / Q000276:immunology*
chemical_list: C491199:EOMES protein, human; D020825:T-Box Domain Proteins