title: Neurological complications of sickle cell disease in Africa: protocol for a systematic review.
abstract: Sickle cell disease (SCD) is highly prevalent in Africa. Considered as a public health problem, it is associated with high morbidity and mortality. Neurological complications of SCD can cause significant disability with important socioeconomic and psychological impact on the patients and their families, and can even lead to death if not properly managed. There are important knowledge gaps regarding the burden of neurological complications of SCD in African populations. We propose to conduct the first systematic review to summarise the epidemiological data available on neurological complications of SCD in Africa.
  
  
  
  We will search PubMed, MEDLINE, EMBASE and the African Index Medicus from 1 January 1950 to 31 May 2016 for studies of neurological complications of SCD in Africa. After study selection, full-text paper acquisition, data extraction and synthesis, we will assess all studies for quality, risk of bias and heterogeneity. Appropriate methods of meta-analysis will be used to pool prevalence estimates from studies with similar features, globally and in major subgroups. This protocol complies with the 2015 Preferred Reporting Items for Systematic reviews and Meta-Analysis protocols (PRISMA-P) guidelines.
  
  
  
  The proposed study will use published data. Therefore, there is no requirement for ethical approval. This review is expected to provide relevant data to help quantify the burden of neurological complications of SCD in African populations, inform policymakers and identify further research topics. The final report of the systematic review will be published in a peer-reviewed journal and presented at conferences.
  
  
  
  CRD42016039574.
authors: Department of Medicine and Medical Specialties, Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, Cameroon.
authors: Michel K
authors: MK
authors: Mengnjo
authors: Brain Infections Group, Institute of Infection and Global Health, University of Liverpool, Liverpool, UK.|Department of Neurology, The Walton Centre for Neurology and Neurosurgery, Liverpool, UK.
authors: Joseph
authors: J
authors: Kamtchum-Tatuene
authors: Division of Neurorehabilitation, Department of Clinical Neurosciences, Geneva University Hospitals, Geneva, Switzerland.
authors: Nicolas
authors: N
authors: Nicastro
authors: Department of Medicine, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa.
authors: Jean Jacques N
authors: JJ
authors: Noubiap
mesh_terms: D000349:Africa / Q000453:epidemiology; D000755:Anemia, Sickle Cell / Q000150:complications* / Q000453:epidemiology / Q000503:physiopathology; D006801:Humans; D009422:Nervous System Diseases / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology; D015995:Prevalence; D011634:Public Health; D000078202:Systematic Reviews as Topic
keywords: Africa; Neurological complications; Sickle cell disease