title: [The expression of p27Kip1and β-catenin in multiple endocrine neoplasia type 1-related parathyroid tumors].
abstract: Objective:To explore tissue expression of cyclin-dependent kinase inhibitor p27Kip1and β-catenin in multiple endocrine neoplasia type1 (MEN1)-related parathyroid tumors (MHPT).Methods:Immunohistochemistry was performed to analyze the expression of p27Kip1and β-catenin in parathyroid glands from 31 subjects with MHPT collected at Peking Union Medical College Hospital from 2002 to 2013. Five normal parathyroid glands were used as control.Results:In MHPT subjects, nuclear expression of p27Kip1was absent in 4 (12.9%), weak in 10 (32.3%) and moderated staining in 17 parathyroid specimens (54.8%), respectively. While, in normal subjects, the nuclear expression of p27Kip1was observed in all subjects and was stronger than that from MHPT subjects (P=0.001). As to the expression of β-catenin, normal parathyroid showed a distinct to moderate membrane staining, a moderate to weak cytoplasmic staining and negative nuclear staining. Similarly, MHPT exhibited a marked to moderate membrane (P=0.087), a moderated to weak cytoplasmic (P=0.357), and negative nuclear β-catenin staining.Conclusions:The expression of p27Kip1is reduced or absent in MHPT tissue, and no nuclear expression of β-catenin is observed in the tumors, which suggesting p27Kip1,but not β-catenin nuclear accumulation, play a role in the development of the tumors.
authors: Department of Endocrinology, Key Laboratory of Endocrinology, National Health and Family Planning Commission, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
authors: J
authors: J
authors: Kong
authors: O
authors: O
authors: Wang
authors: M
authors: M
authors: Nie
authors: J
authors: J
authors: Shi
authors: Y
authors: Y
authors: Jiang
authors: M
authors: M
authors: Li
authors: W B
authors: WB
authors: Xia
authors: X W
authors: XW
authors: Meng
authors: X P
authors: XP
authors: Xing
mesh_terms: D050760:Cyclin-Dependent Kinase Inhibitor p27 / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D018761:Multiple Endocrine Neoplasia Type 1 / Q000235:genetics*; D010282:Parathyroid Neoplasms / Q000235:genetics* / Q000473:pathology; D051176:beta Catenin / Q000235:genetics*
chemical_list: D051176:beta Catenin; D050760:Cyclin-Dependent Kinase Inhibitor p27