title: Associations of genetic variants for adult lipid levels with lipid levels in children. The Generation R Study.
abstract: Lipid concentrations are heritable traits. Recently, the number of known genetic loci associated with lipid levels in adults increased from 95 to 157. The effects of these 157 loci have not been tested in children. Considering that lipid levels track from childhood to adulthood, we studied to determine whether these variants already affected lipid concentrations in a large group of 2,645 children with a median age of 6.0 years (95% range 5.7-7.3 years) from the population-based Generation R Study. Twenty-eight SNPs associated with TGs, 39 SNPs associated with total cholesterol (TC), 28 SNPs associated with LDL cholesterol (LDL-C), and 56 SNPs associated with HDL cholesterol (HDL-C) were analyzed individually and combined into genetic risk scores (GRSs). All risk scores were associated with their specific outcomes. The differences in mean absolute lipid and lipoprotein values between the 10% of children with the highest lipid or lipoprotein GRS versus the 10% with the lowest score were 0.28, 0.25, 0.32, and 0.30 mmol/l for TGs, TC, LDL-C, and HDL-C, respectively. In conclusion, we show for the first time that GRSs based on 157 SNPs associated with adult lipid concentrations are associated with lipid levels in children. The genetic background of these phenotypes at least partly overlaps between children and adults.
authors: The Generation R Study Group Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
authors: Ardashel
authors: A
authors: Latsuzbaia
authors: The Generation R Study Group Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands; Departments of Epidemiology Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands; Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
authors: Vincent W V
authors: VWV
authors: Jaddoe
authors: Departments of Epidemiology Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
authors: Albert
authors: A
authors: Hofman
authors: Departments of Epidemiology Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
authors: Oscar H
authors: OH
authors: Franco
authors: The Generation R Study Group Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands; Departments of Epidemiology Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands; Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands. Electronic address: j.felix@erasmusmc.nl.
authors: Janine F
authors: JF
authors: Felix
mesh_terms: D002648:Child; D008076:Cholesterol, HDL / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood*; D050171:Dyslipidemias / Q000097:blood / Q000235:genetics; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D040641:Quantitative Trait Loci; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood*
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides
keywords: cholesterol; dyslipidemias; genetic risk score; genetics; high density lipoprotein; low density lipoprotein; triglycerides