title: [Research Progress of Necroptosis in Hematological Malignancies -Review].
abstract: Necroptosis is a novel programmed cell death mechanism which is characterized by a necrotic morphology, but the necroptosis is precisely regulated by cellular signaling pathway just like apoptosis. Recently, many reports have revealed that necroptosis contributes to the pathogenesis of inflammation, ischemic reperfusion injury and tumour. Hematological malignancies are a set of hemotopathy diseases with poor prognosis. In this review, the research progress of signaling pathway of necroptosis and its role in hematological malignancies are summarized.
authors: Department of Pediatric Hematology,Shengjing Hospital of China Medical University,Shenyang 110022, Liaoning Province, China.
authors: Zuo-Fei
authors: ZF
authors: Chi
authors: Second Department of Hematology,Shengjing Hospital of China Medical University,Shenyang 110022, Liaoning Province, China. E-mail:yangw@sj-hospital.org.
authors: Wei
authors: W
authors: Yang
authors: Department of Pediatric Hematology,Shengjing Hospital of China Medical University,Shenyang 110022, Liaoning Province, China.
authors: Qiu-Ying
authors: QY
authors: He
authors: Blood Research Laboratory, Shengjing Hospital of China Medical University,Shenyang 110022, Liaoning Province, China.
authors: Shuang
authors: S
authors: Fu
authors: Blood Research Laboratory, Shengjing Hospital of China Medical University,Shenyang 110022, Liaoning Province, China.
authors: Yu
authors: Y
authors: Fu
mesh_terms: D017209:Apoptosis; D019337:Hematologic Neoplasms; D006801:Humans; D009336:Necrosis; D009369:Neoplasms; D015398:Signal Transduction