title: Prognostic Significance of Vas Deferens Invasion After Radical Prostatectomy in Patients with Pathological Stage T3b Prostate Cancer.
abstract: BACKGROUND
  Seminal vesicle invasion (SVI) is associated with adverse clinical outcomes in prostate cancer (PCa) patients. Despite its anatomical similarity and close proximity to the seminal vesicle, the prognostic significance of vas deferens invasion (VDI) by PCa has not been elucidated. For these reasons, we investigated the impact of VDI on the oncological outcome of pT3b PCa in association with SVI.
  
  
  METHODS
  We retrospectively reviewed the medical records of 3359 patients who had undergone a radical prostatectomy at our institution between January 2000 and December 2014 for PCa. Patients who received neoadjuvant or adjuvant treatment (radiation, androgen deprivation therapy, or both) and those without adequate medical records were excluded. A Kaplan-Meier analysis was performed to analyze biochemical recurrence-free survival (BCRFS), and a Cox regression model was used to test the influence of VDI on biochemical recurrence (BCR).
  
  
  RESULTS
  Of 350 patients with pathologically confirmed SVI (pT3b), 87 (24.9%) had VDI, while the remaining 263 patients (75.1%) had isolated SVI. Compared with SVI patients without VDI, SVI patients with VDI were noted to have a significantly worse 5-year BCRFS (25.1 vs. 17.1%, respectively). VDI was a significant predictor of BCR in multivariate Cox regression analysis (hazard ratio 1.39, 95% confidence interval 1.02-1.90; p = 0.039).
  
  
  CONCLUSIONS
  Our results shows that the prognosis of PCa with SVI might be further stratified by VDI status, thus suggesting the role of VDI either as a surrogate for poor prognosis or as a determinant for adjuvant therapy.
authors: Department of Urology, Urological Science Institute, Yonsei University College of Medicine, Seoul, Korea.
authors: Won Sik
authors: WS
authors: Jang
authors: Department of Urology, Urological Science Institute, Yonsei University College of Medicine, Seoul, Korea.
authors: Cheol Yong
authors: CY
authors: Yoon
authors: Department of Urology, Urological Science Institute, Yonsei University College of Medicine, Seoul, Korea.
authors: Ki Hong
authors: KH
authors: Kim
authors: Department of Urology, Urological Science Institute, Yonsei University College of Medicine, Seoul, Korea.
authors: Yong Jin
authors: YJ
authors: Kang
authors: Department of Pathology, Yonsei University College of Medicine, Seoul, Korea.
authors: Su-Jin
authors: SJ
authors: Shin
authors: Department of Pathology, Yonsei University College of Medicine, Seoul, Korea.
authors: Nam Hoon
authors: NH
authors: Cho
authors: Department of Urology, Urological Science Institute, Yonsei University College of Medicine, Seoul, Korea.
authors: Joo Yong
authors: JY
authors: Lee
authors: Department of Urology, Urological Science Institute, Yonsei University College of Medicine, Seoul, Korea.
authors: Kang Su
authors: KS
authors: Cho
authors: Department of Urology, Urological Science Institute, Yonsei University College of Medicine, Seoul, Korea.
authors: Won Sik
authors: WS
authors: Ham
authors: Department of Urology, Urological Science Institute, Yonsei University College of Medicine, Seoul, Korea.
authors: Koon Ho
authors: KH
authors: Rha
authors: Department of Urology, Urological Science Institute, Yonsei University College of Medicine, Seoul, Korea.
authors: Sung Joon
authors: SJ
authors: Hong
authors: Department of Urology, Urological Science Institute, Yonsei University College of Medicine, Seoul, Korea. youngd74@yuhs.ac.
authors: Young Deuk
authors: YD
authors: Choi
mesh_terms: D000368:Aged; D018572:Disease-Free Survival; D006801:Humans; D053208:Kaplan-Meier Estimate; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D018365:Neoplasm, Residual; D016016:Proportional Hazards Models; D017430:Prostate-Specific Antigen / Q000097:blood; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000097:blood / Q000473:pathology* / Q000601:surgery*; D012189:Retrospective Studies; D012669:Seminal Vesicles / Q000473:pathology; D014649:Vas Deferens / Q000473:pathology*
chemical_list: D017430:Prostate-Specific Antigen