title: The Potential of Secondary Metabolites from Plants as Drugs or Leads against Protozoan Neglected Diseases-Part III: In-Silico Molecular Docking Investigations.
abstract: Malaria, leishmaniasis, Chagas disease, and human African trypanosomiasis continue to cause considerable suffering and death in developing countries. Current treatment options for these parasitic protozoal diseases generally have severe side effects, may be ineffective or unavailable, and resistance is emerging. There is a constant need to discover new chemotherapeutic agents for these parasitic infections, and natural products continue to serve as a potential source. This review presents molecular docking studies of potential phytochemicals that target key protein targets inLeishmaniaspp.,Trypanosomaspp., andPlasmodiumspp.
authors: Department of Chemistry and Biochemistry, Jackson State University, Jackson, MS 39217, USA. ifedayo.v.ogungbe@jsums.edu.
authors: Ifedayo Victor
authors: IV
authors: Ogungbe
authors: Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA. wsetzer@chemistry.uah.edu.
authors: William N
authors: WN
authors: Setzer
mesh_terms: D000981:Antiprotozoal Agents / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D001688:Biological Products / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D003198:Computer Simulation; D055808:Drug Discovery; D006801:Humans; D008958:Models, Molecular; D062105:Molecular Docking Simulation; D015394:Molecular Structure; D058069:Neglected Diseases / Q000188:drug therapy*; D008517:Phytotherapy; D011528:Protozoan Infections / Q000188:drug therapy*; D015800:Protozoan Proteins / Q000737:chemistry* / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D000981:Antiprotozoal Agents; D001688:Biological Products; D015800:Protozoan Proteins
keywords: Leishmania; Plasmodium; Trypanosoma; natural products drug discovery