title: Low-temperature deposition manufacturing: A novel and promising rapid prototyping technology for the fabrication of tissue-engineered scaffold.
abstract: Developed in recent years, low-temperature deposition manufacturing (LDM) represents one of the most promising rapid prototyping technologies. It is not only based on rapid deposition manufacturing process but also combined with phase separation process. Besides the controlled macropore size, tissue-engineered scaffold fabricated by LDM has inter-connected micropores in the deposited lines. More importantly, it is a green manufacturing process that involves non-heating liquefying of materials. It has been employed to fabricate tissue-engineered scaffolds for bone, cartilage, blood vessel and nerve tissue regenerations. It is a promising technology in the fabrication of tissue-engineered scaffold similar to ideal scaffold and the design of complex organs. In the current paper, this novel LDM technology is introduced, and its control parameters, biomedical applications and challenges are included and discussed as well.
authors: Shenzhen Key Laboratory of Tissue Engineering, Shenzhen Second People's Hospital, Shenzhen 518035, China; Shenzhen Laboratory of Digital Orthopeadic Engineering, Shenzhen Second People's Hospital, Shenzhen 518035, China; Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China; Shenzhen Centre of Sports Medicine & Engineering Technology, Shenzhen Second People's Hospital, Shenzhen 518035, China.
authors: Wei
authors: W
authors: Liu
authors: Shenzhen Key Laboratory of Tissue Engineering, Shenzhen Second People's Hospital, Shenzhen 518035, China.
authors: Daming
authors: D
authors: Wang
authors: Shenzhen Key Laboratory of Tissue Engineering, Shenzhen Second People's Hospital, Shenzhen 518035, China; Shenzhen Laboratory of Digital Orthopeadic Engineering, Shenzhen Second People's Hospital, Shenzhen 518035, China.
authors: Jianghong
authors: J
authors: Huang
authors: Shenzhen Laboratory of Digital Orthopeadic Engineering, Shenzhen Second People's Hospital, Shenzhen 518035, China.
authors: You
authors: Y
authors: Wei
authors: Shenzhen Key Laboratory of Tissue Engineering, Shenzhen Second People's Hospital, Shenzhen 518035, China; Shenzhen Laboratory of Digital Orthopeadic Engineering, Shenzhen Second People's Hospital, Shenzhen 518035, China.
authors: Jianyi
authors: J
authors: Xiong
authors: Shenzhen Key Laboratory of Tissue Engineering, Shenzhen Second People's Hospital, Shenzhen 518035, China; Shenzhen Centre of Sports Medicine & Engineering Technology, Shenzhen Second People's Hospital, Shenzhen 518035, China.
authors: Weimin
authors: W
authors: Zhu
authors: Shenzhen Key Laboratory of Tissue Engineering, Shenzhen Second People's Hospital, Shenzhen 518035, China.
authors: Li
authors: L
authors: Duan
authors: Shenzhen Key Laboratory of Tissue Engineering, Shenzhen Second People's Hospital, Shenzhen 518035, China.
authors: Jielin
authors: J
authors: Chen
authors: Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
authors: Rong
authors: R
authors: Sun
authors: Shenzhen Key Laboratory of Tissue Engineering, Shenzhen Second People's Hospital, Shenzhen 518035, China; Shenzhen Laboratory of Digital Orthopeadic Engineering, Shenzhen Second People's Hospital, Shenzhen 518035, China; Shenzhen Centre of Sports Medicine & Engineering Technology, Shenzhen Second People's Hospital, Shenzhen 518035, China. Electronic address: dapingwang1963@foxmail.com.
authors: Daping
authors: D
authors: Wang
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000502:physiology; D002356:Cartilage / Q000502:physiology; D006801:Humans; D013696:Temperature; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds / Q000737:chemistry*
keywords: Cartilage regeneration; Low-temperature deposition manufacturing; Prototyping technology; Three-dimensional scaffold; Tissue-engineered scaffold