title: Negative Impact of Total Body Irradiation on the Antitumor Activity of Rhenium-(I)-diselenoether.
abstract: It has been shown that a rhenium-(I)-diselenoether complex had significant antitumor activity in MDA-MB231 tumor-bearing mice after repeated oral or intraperitoneal administrations for 4 weeks at safe doses of 10 mg/kg/day. It has also been suggested that lower doses could be as effective as this dose. We, thus, tested two doses (5 and 10 mg/kg). The drug was orally administered daily by gavage for 4 weeks and for a further 2 weeks with or without 15 mg/kg paclitaxel treatment (intravenously, once a week). This experiment was performed in MDA-MB 231 tumor-bearing mice, as a model of resistant breast tumor. However, in contrast to previous studies, the mice were pretreated with total body irradiation to increase the tumor growth. These two doses were safe, even in combination with paclitaxel. The expected tumor regression was not observed with the rhenium-(I)-diselenoether complex, and there was even a significant increase of the tumor volume in mice treated with 10 mg/kg versus controls. No synergism was observed with paclitaxel. We comment on the possible negative impact of radiotherapy on the antitumor activity of the drug. Plasma and tumor rhenium and selenium concentrations are also reported.
authors: Society for the Coordination of Research, Algajola, France philippe.collery@gmail.com.|Research and Development Center for the Therapeutic Use of Organo-Metallic Compounds, Maymard Polyclinic, Bastia, France.
authors: Philippe
authors: P
authors: Collery
authors: Research and Development Center for the Therapeutic Use of Organo-Metallic Compounds, Maymard Polyclinic, Bastia, France.|Laboratory of the Corsican Office of Hydraulic Equipment, Bastia, France.
authors: Francois
authors: F
authors: Santoni
authors: UMR CNRS 8612, Galien Institute, Faculty of Pharmacy, University Paris-Saclay, Châtenay-Malabry, France.
authors: Ahmed
authors: A
authors: Mohsen
authors: Oncodesign, Dijon, France.
authors: Caroline
authors: C
authors: Mignard
authors: UMR CNRS 8612, Galien Institute, Faculty of Pharmacy, University Paris-Saclay, Châtenay-Malabry, France.
authors: Didier
authors: D
authors: Desmaele
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000493:pharmacokinetics / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D012211:Rhenium / Q000627:therapeutic use*; D018036:Selenium Compounds / Q000493:pharmacokinetics / Q000627:therapeutic use*; D014916:Whole-Body Irradiation; D023041:Xenograft Model Antitumor Assays
chemical_list: D000970:Antineoplastic Agents; D018036:Selenium Compounds; D012211:Rhenium
keywords: MDA-MB231; Rhenium (Re); bioluminescence; breast cancer; in vivo experiment; mice; radiotherapy; selenium (Se)