title: Bio-functionalization of biomedical metals.
abstract: Bio-functionalization means to endow biomaterials with bio-functions so as to make the materials or devices more suitable for biomedical applications. Traditionally, because of the excellent mechanical properties, the biomedical metals have been widely used in clinic. However, the utilized functions are basically supporting or fixation especially for the implantable devices. Nowadays, some new functions, including bioactivity, anti-tumor, anti-microbial, and so on, are introduced to biomedical metals. To realize those bio-functions on the metallic biomedical materials, surface modification is the most commonly used method. Surface modification, including physical and chemical methods, is an effective way to alter the surface morphology and composition of biomaterials. It can endow the biomedical metals with new surface properties while still retain the good mechanical properties of the bulk material. Having analyzed the ways of realizing the bio-functionalization, this article briefly summarized the bio-functionalization concepts of six hot spots in this field. They are bioactivity, bony tissue inducing, anti-microbial, anti-tumor, anticoagulation, and drug loading functions.
authors: Engineering Research Center in Biomaterials, Sichuan University, Chengdu 610064, China; National Engineering Research Center for Biomaterials, Chengdu, 610064, China.
authors: M
authors: M
authors: Xiao
authors: Engineering Research Center in Biomaterials, Sichuan University, Chengdu 610064, China; National Engineering Research Center for Biomaterials, Chengdu, 610064, China.
authors: Y M
authors: YM
authors: Chen
authors: Engineering Research Center in Biomaterials, Sichuan University, Chengdu 610064, China; National Engineering Research Center for Biomaterials, Chengdu, 610064, China.
authors: M N
authors: MN
authors: Biao
authors: Engineering Research Center in Biomaterials, Sichuan University, Chengdu 610064, China; National Engineering Research Center for Biomaterials, Chengdu, 610064, China.
authors: X D
authors: XD
authors: Zhang
authors: Engineering Research Center in Biomaterials, Sichuan University, Chengdu 610064, China; National Engineering Research Center for Biomaterials, Chengdu, 610064, China. Electronic address: yangbchengc@126.com.
authors: B C
authors: BC
authors: Yang
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology; D000925:Anticoagulants / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000494:pharmacology; D001672:Biocompatible Materials / Q000494:pharmacology*; D006801:Humans; D008670:Metals / Q000494:pharmacology*; D016348:Osseointegration / Q000187:drug effects
chemical_list: D000890:Anti-Infective Agents; D000925:Anticoagulants; D000970:Antineoplastic Agents; D001672:Biocompatible Materials; D008670:Metals
keywords: Bio-function; Biomedical metal; Magnesium; Titanium