title: Visual disturbance with systemic symptoms: old lessons revisited.
abstract: We describe a retired physician who presented with visual disturbance and systemic symptoms. The presence of general malaise, headache and scalp tenderness, with raised inflammatory markers, suggested that giant cell arteritis (GCA) was the likely diagnosis. Rapid response to initial steroid therapy and histological evidence of inflammation in the temporal artery supported this diagnosis. The character of these visual symptoms was, however, atypical for GCA. The patient, who had heart valve disease, subsequently deteriorated and developed further symptoms warranting investigation of bacterial endocarditis. Retinal emboli are a recognised complication of endocarditis, which could account for these visual symptoms. Moreover, interpretation of the temporal artery biopsy is limited in the context of existing steroid therapy. Our patient was consequently diagnosed with bacterial endocarditis. This case reminds us to consider the wider differential diagnoses for headache, visual disturbance and systemic symptoms, where echocardiogram and blood cultures may be crucial to reach the diagnosis.
authors: NHS Lothian, Edinburgh, UK.
authors: Megan E
authors: ME
authors: Hume
authors: Department of Neurology, NHS Lothian, Edinburgh, UK.|Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
authors: Peter M
authors: http://orcid.org/0000-0003-4061-2872
authors: PM
authors: Fernandes
authors: NHS Grampian, Aberdeen, UK.
authors: Kirsty
authors: K
authors: MacLean
authors: Department of Rheumatology, NHS Lothian, Edinburgh, UK.
authors: Euan
authors: E
authors: McRorie
authors: Department of Rheumatology, NHS Lothian, Edinburgh, UK.
authors: Richard
authors: R
authors: Davenport
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D003937:Diagnosis, Differential; D003952:Diagnostic Imaging; D004697:Endocarditis, Bacterial / Q000175:diagnosis* / Q000188:drug therapy; D013700:Giant Cell Arteritis / Q000175:diagnosis* / Q000188:drug therapy; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008297:Male; D011239:Prednisolone / Q000627:therapeutic use; D014786:Vision Disorders / Q000188:drug therapy / Q000209:etiology
chemical_list: D000900:Anti-Bacterial Agents; D005938:Glucocorticoids; D011239:Prednisolone