title: Hormonal and testicular changes in rats submitted to congenital hypothyroidism in early life.
abstract: The goal of this study was to evaluate the influence of hypothyroidism induced by MMI, during gestation (G) or gestation plus lactation (GL) on testis and its relation with leptin in rats. Six to eight pups were killed at 90 days of age. For statistical analysis One-way ANOVA followed by the Holm-Sìdak post hoc test was used. Hypothyroidism resulted in a significant reduction in LH, FSH and testosterone and an increase in leptin serum levels (p < 0.04). There was a significant decrease in StAR, AR, FSHR, LHR, pSTAT3 and SOCS3 (p < 0.04) protein expression and in the fertility parameters (p < 0.04). We can conclude that hypothyroidism is associated with reduction of steroidogenesis and spermatogenesis leading to a low fertility potential in these animals. This outcome could be a consequence of low pituitary stimulus and testicular response and probably are not related with leptin hormone since its signaling pathway is down-regulated in the testis.
authors: Laboratory of Morphometry, Metabolism and Cardiovascular Disease, Biomedical Center, Institute of Biology, State University of Rio de Janeiro, Brazil.
authors: Veronica
authors: V
authors: Aiceles
authors: Laboratory of Morphometry, Metabolism and Cardiovascular Disease, Biomedical Center, Institute of Biology, State University of Rio de Janeiro, Brazil.
authors: Flavia
authors: F
authors: Gombar
authors: Laboratory of Morphometry, Metabolism and Cardiovascular Disease, Biomedical Center, Institute of Biology, State University of Rio de Janeiro, Brazil. Electronic address: cristiane@pesquisador.cnpq.br.
authors: Cristiane
authors: C
authors: da Fonte Ramos
mesh_terms: D000818:Animals; D001835:Body Weight; D003409:Congenital Hypothyroidism / Q000097:blood / Q000378:metabolism* / Q000473:pathology*; D005247:Feeding Behavior; D005260:Female; D005298:Fertility / Q000235:genetics; D005786:Gene Expression Regulation; D006728:Hormones / Q000097:blood / Q000378:metabolism*; D007774:Lactation; D008297:Male; D008954:Models, Biological; D011247:Pregnancy; D017208:Rats, Wistar; D013094:Spermatozoa / Q000378:metabolism; D013737:Testis / Q000378:metabolism / Q000473:pathology*
chemical_list: D006728:Hormones
keywords: Fertility; Hypothyroidism; Leptin; Testis