title: Tolerance to a Hair Dye Product Containing 2-Methoxymethyl-P-Phenylenediamine in an Ethnically Diverse Population of P-Phenylenediamine-Allergic Individuals.
abstract: BACKGROUND
  Allergic contact dermatitis after exposure to p-phenylenediamine (PPD)-containing hair dye products is a common and important clinical problem. Because there is a high rate of cross-elicitation of allergic contact dermatitis to other important hair dye products (such as p-toluene diamine and other aminophenol hair dyes) in PPD-allergic patients, safer alternative dyes with excellent hair coloring options are needed.
  
  
  OBJECTIVE
  This study aimed to study tolerance to Me-PPD in a PPD-allergic cohort.
  
  
  METHODS
  Twenty ethnically diverse volunteers with a history of contact dermatitis to hair dyes or other PPD-containing chemicals and positive patch test results to 1% PPD in petrolatum were recruited to study their immediate and delayed skin reactivity to PPD, vehicle control, and 2-methoxy-methyl-PPD (Me-PPD) using the allergy alert test (simulating hair dyeing conditions) on volar forearm skin. This test is a short-contact open patch test.
  
  
  CONCLUSIONS
  The Me-PPD may offer a safer alternative for PPD-allergic patients with an absent or reduced elicitation response in the allergy alert test simulating hair dye use conditions. The absent or reduced response to Me-PPD diagnosed using the allergy alert test has been shown to help reduce the possibility of moderate to severe cross-elicitation reactions among consumers during hair dyeing.
authors: From the *Department of Dermatology, School of Medicine, University of Maryland Baltimore; †Union Memorial Hospital, Baltimore, MD; ‡Department of Environmental Toxicology, University of Trier; and §The Procter & Gamble Company, Central Product Safety, Schwalbach am Taunus, Germany.
authors: Amir
authors: A
authors: Zahir
authors: Chesahna
authors: C
authors: Kindred
authors: Brunhilde
authors: B
authors: Blömeke
authors: Carsten
authors: C
authors: Goebel
authors: Anthony A
authors: AA
authors: Gaspari
mesh_terms: D000328:Adult; D001741:Black or African American; D000368:Aged; D044466:Asian People; D015331:Cohort Studies; D003429:Cross Reactions / Q000276:immunology; D017449:Dermatitis, Allergic Contact / Q000453:epidemiology / Q000208:ethnology / Q000209:etiology* / Q000276:immunology; D005006:Ethnicity; D005260:Female; D006202:Hair Dyes / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010328:Patch Tests; D010655:Phenylenediamines / Q000009:adverse effects* / Q000276:immunology; D044465:White People
chemical_list: D006202:Hair Dyes; D010655:Phenylenediamines; C587181:2-methoxymethyl-p-phenylenediamine; C029728:4-phenylenediamine