title: [Clinical study of pulsed high- dose dexamethasone treatment in 38 children with primary immune thrombocytopenic purpura].
abstract: Objective:To evaluate the efficacy and safety of pulsed high- dose dexamethasone(HDD)treatment in children with primary immune thrombocytopenic purpura(ITP).Method:ITP children who failed to first-line therapy from September 2013 to September 2014 were given pulsed HDD treatment, dexamethasone was administered at a dosage of 0.6 mg ·kg-1·d-1(maximum 40 mg/d)for 4 consecutive days. The cycle was repeated every 28 days for 6 months.Results:①A total of 38 cases were enrolled, 26 boys and 12 girls, median age was 54(6-151)months, median duration of disease was 6(1- 72)months, 9 cases was newly diagnosed ITP, 13 cases with persistent ITP, 16 cases with chronic ITP. Median platelet count before treatment was 16.3(1.0- 30.0)× 109/L. ②A median follow- up time was 180(90- 554)days. Treatment response was obtained in 17 cases(44.7%), including 7 cases(18.4%)with complete response(CR), 10 cases(26.3%)response(R); the median time to response was 80.5(23-245)days. Of 17 CR/R cases, 3 turned to no response, with a median duration of response 63(37-67)days. Of 38 cases, 21(55.3%)was no response, but the bleeding symptoms in 85.7% of this group improved. ③ Only 1 patient had mild reversible side effects during treatment. ④ The percentage of CD4+CD25+Foxp3+T cells is higher in effective group than that in ineffective group[(7.54±1.50)%vs(5.69±1.95)%,P=0.049]. Univariate analyses suggested that the efficacy of HDD treatment in children with megakaryocyte count <300/slide is better than that >300/slide(P=0.049).Conclusion:Pulsed HDD treatment is a comparatively safe and effective choice for children with ITP who failed to first-line therapy. Children with less than 300 megakaryocytes or higher CD4+CD25+Foxp3+T cells may be more suitable for the therapy.
authors: Beijing Children's Hospital, Capital Medical University, Beijing 100045, China.
authors: J
authors: J
authors: Ma
authors: L L
authors: LL
authors: Fu
authors: Z P
authors: ZP
authors: Chen
authors: J Y
authors: JY
authors: Ma
authors: R
authors: R
authors: Zhang
authors: Y
authors: Y
authors: Su
authors: L
authors: L
authors: Zhang
authors: Y Y
authors: YY
authors: Wei
authors: R H
authors: RH
authors: Wu
mesh_terms: D000293:Adolescent; D002452:Cell Count; D002648:Child; D002675:Child, Preschool; D003907:Dexamethasone; D005260:Female; D006470:Hemorrhage; D006801:Humans; D007223:Infant; D053645:Interleukin-2 Receptor alpha Subunit; D008297:Male; D008533:Megakaryocytes; D010976:Platelet Count; D016553:Purpura, Thrombocytopenic, Idiopathic; D012074:Remission Induction
chemical_list: C508017:IL2RA protein, human; D053645:Interleukin-2 Receptor alpha Subunit; D003907:Dexamethasone