title: [Expression of microRNA-155 in papillary thyroid carcinoma and its clinical significance].
abstract: OBJECTIVE
  To investigate the correlation of microRNA-155 (miR-155) expression with clinicopathological features of patients with papillary thyroid carcinoma (PTC) and explore the value of miR-155 in prognostic assessment of PTC.
  
  
  METHODS
  We collected 86 pairs of fresh PTC and adjacent tissues to examine the expression of miR-155 using fluorescent quantitative PCR. miR-155 expressions in the tissues were analyzed in relation to the clinicopathological features of the patients.
  
  
  RESULTS
  Compared with the paired adjacent tissues, 69.8% (60/86) of the PTC tissues showed up-regulated miR-155 expression by 2.63∓2.73 folds. Up-regulated miR-155 expressions were associated with a larger tumor size (1.66∓0.96 vs 1.19∓0.52 cm, P=0.021), a higher likeliness of extrathyroid invasion (56.7% vs 23.1%, P=0.004), a higher rate of lymph node metastasis (70% vs 46.2%, P=0.036), a more advanced TNM stage, and a higher rate of III-IV stage of the tumor (20% vs 0%, P=0.014). The expression level of miR-155 in PTC tissues was positively correlated with lymph node metastasis (r=0.531, P=0.001).
  
  
  CONCLUSIONS
  PTC patients with miR-155 over-expression tend to have a greater tumor size, a greater likeliness of extrathyroid involvement, a higher rate of cervical lymph node metastasis and a more advanced TNM stage. The high expression of miR-155 in the tumor may indicate a poor prognosis of PTC patients.
authors: Department of Thyroid and Breast Surgery, First Affiliated Hospital of Fujian Medical University, Fuzhou 350000, China. E-mail: zhu1755@sina.com.
authors: You-Zhi
authors: YZ
authors: Zhu
authors: Ke
authors: K
authors: Zheng
authors: Hui-Hao
authors: HH
authors: Zhang
authors: Ling
authors: L
authors: Chen
authors: Kun-Lin
authors: KL
authors: Wu
authors: Cai-Hong
authors: CH
authors: Ren
authors: Zong-Cai
authors: ZC
authors: Wang
authors: Ling-Jun
authors: LJ
authors: Kong
authors: Wei-Hong
authors: WH
authors: Ruan
authors: Xiang-Jin
authors: XJ
authors: Chen
mesh_terms: D002291:Carcinoma, Papillary / Q000235:genetics*; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis; D035683:MicroRNAs / Q000235:genetics*; D009333:Neck; D011379:Prognosis; D000077273:Thyroid Cancer, Papillary; D013964:Thyroid Neoplasms / Q000235:genetics*; D015854:Up-Regulation
chemical_list: C524942:MIRN155 microRNA, human; D035683:MicroRNAs