title: Evolution of disease activity and biomarkers on and off rapamycin in 28 patients with autoimmune lymphoproliferative syndrome.
authors: Center for Chronic Immunodeficiency (CCI), Medical Center, Faculty of Medicine, University of Freiburg, Germany.|Center for Pediatrics, Department of Pediatric Hematology and Oncology, University Medical Center, Faculty of Medicine, University of Freiburg, Germany.
authors: Christian
authors: C
authors: Klemann
authors: INSERM UMR 1163, Laboratory of the immunogenetics of Pediatric Autoimmune Diseases, Paris, France.|Unite d'Immuno Hematologie Pediatrique, Hopital Necker-Enfants Malades, Assistance Publique des Hopitaux de Paris, France.
authors: Myrian
authors: M
authors: Esquivel
authors: INSERM UMR 1163, Laboratory of the immunogenetics of Pediatric Autoimmune Diseases, Paris, France.|Paris Descartes - Sorbonne Paris Cité University, Imagine Institute, France.
authors: Aude
authors: A
authors: Magerus-Chatinet
authors: Institute for Transfusion Medicine, University of Ulm, Germany.|Institute for Clinical Transfusion Medicine and Immunogenetics Ulm, German Red Cross Blood Service, Germany.
authors: Myriam R
authors: MR
authors: Lorenz
authors: Center for Chronic Immunodeficiency (CCI), Medical Center, Faculty of Medicine, University of Freiburg, Germany.
authors: Ilka
authors: I
authors: Fuchs
authors: Service de Biochimie, Hopital Cochin, Assistance Publique Hopitaux de Paris, France.
authors: Nathalie
authors: N
authors: Neveux
authors: Unite d'Immuno Hematologie Pediatrique, Hopital Necker-Enfants Malades, Assistance Publique des Hopitaux de Paris, France.
authors: Martin
authors: M
authors: Castelle
authors: Center for Chronic Immunodeficiency (CCI), Medical Center, Faculty of Medicine, University of Freiburg, Germany.|Center for Pediatrics, Department of Pediatric Hematology and Oncology, University Medical Center, Faculty of Medicine, University of Freiburg, Germany.
authors: Jan
authors: J
authors: Rohr
authors: Department of Pediatric Hematology and Oncology, Hannover Medical School, Germany.
authors: Claudia Bettoni
authors: CB
authors: da Cunha
authors: University Children's Hospital Tübingen, Germany.
authors: Martin
authors: M
authors: Ebinger
authors: Department of Pediatrics, Infectious Diseases and Immunity, University Medical Centre Hamburg-Eppendorf, Germany.
authors: Robin
authors: R
authors: Kobbe
authors: Department of Rheumatology and Clinical Immunology, University Medical Centre Freiburg, Germany.
authors: Bernhard
authors: B
authors: Kremens
authors: University Hospital Essen, Department of Paediatrics III, University of Duisburg-Essen, Germany.
authors: Florian
authors: F
authors: Kollert
authors: Department of "NEUROFARBA": Section of Child's Health, University of Florence, Department of Haematology-Oncology: BMT Unit, Department of Fetal and Neonatal Medicine: Rare Diseases, "Anna Meyer" Children's Hospital, Florence, Italy.
authors: Eleonora
authors: E
authors: Gambineri
authors: Department of Pediatric Haematology/Oncology, University Medical Centre Hamburg, Germany.
authors: Kai
authors: K
authors: Lehmberg
authors: Division of Pediatric Hematology-Oncology, Department of Pediatrics and Adolescent Medicine, Medical University Graz, Austria.
authors: Markus G
authors: MG
authors: Seidel
authors: Department of Pediatric and Adolescent Medicine, HELIOS Klinikum Krefeld, Germany.
authors: Kathrin
authors: K
authors: Siepermann
authors: Hospital for Pediatric Haematology and Oncology, Medical Center Kassel GmbH, Germany.
authors: Thomas
authors: T
authors: Voelker
authors: Hospital for Children and Adolescents, University of Leipzig, Germany.
authors: Volker
authors: V
authors: Schuster
authors: Center for Chronic Immunodeficiency (CCI), Medical Center, Faculty of Medicine, University of Freiburg, Germany.
authors: Sigune
authors: S
authors: Goldacker
authors: Institute for Transfusion Medicine, University of Ulm, Germany.|Institute for Clinical Transfusion Medicine and Immunogenetics Ulm, German Red Cross Blood Service, Germany.
authors: Klaus
authors: K
authors: Schwarz
authors: Center for Chronic Immunodeficiency (CCI), Medical Center, Faculty of Medicine, University of Freiburg, Germany.|Center for Pediatrics, Department of Pediatric Hematology and Oncology, University Medical Center, Faculty of Medicine, University of Freiburg, Germany.
authors: Carsten
authors: C
authors: Speckmann
authors: INSERM UMR 1163, Laboratory of the immunogenetics of Pediatric Autoimmune Diseases, Paris, France.|Unite d'Immuno Hematologie Pediatrique, Hopital Necker-Enfants Malades, Assistance Publique des Hopitaux de Paris, France.|Centre d'Etude des Deficits Immunitaires, Hopital Necker-Enfants Malades, Assistance Publique des Hopitaux de Paris, France.
authors: Capucine
authors: C
authors: Picard
authors: INSERM UMR 1163, Laboratory of the immunogenetics of Pediatric Autoimmune Diseases, Paris, France.|Unite d'Immuno Hematologie Pediatrique, Hopital Necker-Enfants Malades, Assistance Publique des Hopitaux de Paris, France.|College de France, Paris, France.
authors: Alain
authors: A
authors: Fischer
authors: INSERM UMR 1163, Laboratory of the immunogenetics of Pediatric Autoimmune Diseases, Paris, France.|Paris Descartes - Sorbonne Paris Cité University, Imagine Institute, France.
authors: Frederic
authors: F
authors: Rieux-Laucat
authors: Center for Chronic Immunodeficiency (CCI), Medical Center, Faculty of Medicine, University of Freiburg, Germany.|Center for Pediatrics, Department of Pediatric Hematology and Oncology, University Medical Center, Faculty of Medicine, University of Freiburg, Germany.
authors: Stephan
authors: S
authors: Ehl
authors: Center for Chronic Immunodeficiency (CCI), Medical Center, Faculty of Medicine, University of Freiburg, Germany benedicte.neven@aphp.fr anne.rensing-ehl@uniklinik-freiburg.de.
authors: Anne
authors: A
authors: Rensing-Ehl
authors: Unite d'Immuno Hematologie Pediatrique, Hopital Necker-Enfants Malades, Assistance Publique des Hopitaux de Paris, France benedicte.neven@aphp.fr anne.rensing-ehl@uniklinik-freiburg.de.
authors: Benedicte
authors: B
authors: Neven
mesh_terms: D000293:Adolescent; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use*; D056735:Autoimmune Lymphoproliferative Syndrome / Q000188:drug therapy* / Q000235:genetics / Q000276:immunology / Q000473:pathology; D015415:Biomarkers / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D018450:Disease Progression; D004334:Drug Administration Schedule; D053222:Fas Ligand Protein / Q000235:genetics / Q000276:immunology; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007223:Infant; D007231:Infant, Newborn; D016753:Interleukin-10 / Q000235:genetics / Q000276:immunology; D000072281:Lymphadenopathy / Q000188:drug therapy / Q000235:genetics / Q000276:immunology / Q000473:pathology; D008297:Male; D012189:Retrospective Studies; D020123:Sirolimus / Q000627:therapeutic use*; D013163:Splenomegaly / Q000188:drug therapy / Q000235:genetics / Q000276:immunology / Q000473:pathology; D019014:fas Receptor / Q000235:genetics* / Q000276:immunology
chemical_list: D000903:Antibiotics, Antineoplastic; D015415:Biomarkers; C491901:FAS protein, human; C505661:FASLG protein, human; D053222:Fas Ligand Protein; C508609:IL10 protein, human; D007166:Immunosuppressive Agents; D019014:fas Receptor; D016753:Interleukin-10; D020123:Sirolimus