title: Computational Analysis of G-Quadruplex Forming Sequences across Chromosomes Reveals High Density Patterns Near the Terminal Ends.
abstract: G-quadruplex structures (G4) are found throughout the human genome and are known to play a regulatory role in a variety of molecular processes. Structurally, they have many configurations and can form from one or more DNA strands. At the gene level, they regulate gene expression and protein synthesis. In this paper, chromosomal-level patterns of distribution are analyzed on the human genome to identify high-level distribution patterns potentially related to global functional processes. Here we show unique high density banding patterns on individual chromosomes that are highly correlated, appearing in a mirror pattern, across forward and reverse DNA strands. The highest density of G4 sequences occurs within four megabases of one end of most chromosomes and contains G4 motifs that bind with zinc finger proteins. These findings suggest that G4 may play a role in global chromosomal processes such as those found in meiosis.
authors: Department of Psychological and Brain Sciences, University of Louisville, Louisville, KY, United States of America.|Kentucky Biomedical Research Infrastructure Network Bioinformatics Core, University of Louisville, Louisville, KY, United States of America.
authors: Julia H
authors: JH
authors: Chariker
authors: James Graham Brown Cancer Center, University of Louisville, Louisville, KY, United States of America.|Department of Medicine, University of Louisville, Louisville, KY, United States of America.
authors: Donald M
authors: DM
authors: Miller
authors: Kentucky Biomedical Research Infrastructure Network Bioinformatics Core, University of Louisville, Louisville, KY, United States of America.|Department of Computer Engineering and Computer Science, University of Louisville, Louisville KY, United States of America.
authors: Eric C
authors: http://orcid.org/0000-0003-3487-6572
authors: EC
authors: Rouchka
mesh_terms: D002874:Chromosome Mapping; D002877:Chromosomes, Human / Q000737:chemistry* / Q000235:genetics; D019295:Computational Biology / Q000379:methods*; D004247:DNA / Q000737:chemistry; D054856:G-Quadruplexes; D006801:Humans; D008958:Models, Molecular; D016615:Telomere / Q000737:chemistry* / Q000235:genetics
chemical_list: D004247:DNA