title: Spotlight on the relevance of mtDNA in cancer.
abstract: The potential role of the mitochondrial genome has recently attracted interest because of its high mutation frequency in tumors. Different aspects of mtDNA make it relevant for cancer's biology, such as it encodes a limited but essential number of genes for OXPHOS biogenesis, it is particularly susceptible to mutations, and its copy number can vary. Moreover, most ROS in mitochondria are produced by the electron transport chain. These characteristics place the mtDNA in the center of multiple signaling pathways, known as mitochondrial retrograde signaling, which modifies numerous key processes in cancer. Cybrid studies support that mtDNA mutations are relevant and exert their effect through a modification of OXPHOS function and ROS production. However, there is still much controversy regarding the clinical relevance of mtDNA mutations. New studies should focus more on OXPHOS dysfunction associated with a specific mutational signature rather than the presence of mutations in the mtDNA.
authors: Departamento de Bioquímica and Centro de Investigación Biomédica en Red en Enfermedades Raras (CIBERER), Facultad de Medicina, UAM, Madrid, Spain.|Instituto de Investigaciones Biomédicas "Alberto Sols", Consejo Superior de Investigaciones Científicas (CSIC), Universidad Autónoma de Madrid (UAM), C/Arturo Duperier 4, Madrid, Spain.|Servicio de Oncología Médica, Instituto de Investigación Sanitaria Puerta de Hierro, Hospital Universitario Puerta de Hierro-Majadahonda, Calle Manuel de Falla, 1, 28222, Madrid, Spain.
authors: A
authors: http://orcid.org/0000-0001-5136-7011
authors: A
authors: Cruz-Bermúdez
authors: Departamento de Bioquímica and Centro de Investigación Biomédica en Red en Enfermedades Raras (CIBERER), Facultad de Medicina, UAM, Madrid, Spain.|Instituto de Investigaciones Biomédicas "Alberto Sols", Consejo Superior de Investigaciones Científicas (CSIC), Universidad Autónoma de Madrid (UAM), C/Arturo Duperier 4, Madrid, Spain.
authors: R J
authors: RJ
authors: Vicente-Blanco
authors: Servicio de Bioquímica, Instituto de Investigación Sanitaria Puerta de Hierro, Hospital Universitario Puerta de Hierro-Majadahonda, Calle Manuel de Falla 1, 28222, Madrid, Spain.
authors: E
authors: E
authors: Gonzalez-Vioque
authors: Servicio de Oncología Médica, Instituto de Investigación Sanitaria Puerta de Hierro, Hospital Universitario Puerta de Hierro-Majadahonda, Calle Manuel de Falla, 1, 28222, Madrid, Spain.
authors: M
authors: M
authors: Provencio
authors: Departamento de Bioquímica and Centro de Investigación Biomédica en Red en Enfermedades Raras (CIBERER), Facultad de Medicina, UAM, Madrid, Spain.|Instituto de Investigaciones Biomédicas "Alberto Sols", Consejo Superior de Investigaciones Científicas (CSIC), Universidad Autónoma de Madrid (UAM), C/Arturo Duperier 4, Madrid, Spain.|Instituto de Investigación Sanitaria Hospital 12 de Octubre (i+12), Madrid, Spain.
authors: M Á
authors: MÁ
authors: Fernández-Moreno
authors: Departamento de Bioquímica and Centro de Investigación Biomédica en Red en Enfermedades Raras (CIBERER), Facultad de Medicina, UAM, Madrid, Spain. rafael.garesse@uam.es.|Instituto de Investigaciones Biomédicas "Alberto Sols", Consejo Superior de Investigaciones Científicas (CSIC), Universidad Autónoma de Madrid (UAM), C/Arturo Duperier 4, Madrid, Spain. rafael.garesse@uam.es.|Instituto de Investigación Sanitaria Hospital 12 de Octubre (i+12), Madrid, Spain. rafael.garesse@uam.es.
authors: R
authors: R
authors: Garesse
mesh_terms: D004272:DNA, Mitochondrial / Q000235:genetics*; D006801:Humans; D008928:Mitochondria / Q000235:genetics*; D009154:Mutation / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology*
chemical_list: D004272:DNA, Mitochondrial
keywords: Cancer; Mitochondria; OXPHOS; ROS; Warburg effect; mtDNA