title: Association between Pax8-PPARandgamma;1 Rearrangement and Follicular Thyroid Cancer: a Meta-Analysis.
abstract: BACKGROUND
  Pax8 and peroxisome proliferator-activated receptor gamma 1 gene (Pax8-PPARγ1) are important factors in tumors. Several studies have suggested that follicular thyroid cancer may arise from Pax8- PPArγ1 rearrangement. In order to have a better understanding of the association between Pax8-PPARγ1 rearrangement and follicular thyroid cancer, we conducted the presenmt meta-analysis.
  
  
  METHODS
  The information was extracted from PubMed, EMBASE and Web of Science. Statistic analysis was performed with Stata12.0 software. Odds ratios (ORs) were calculated using a fixed-effects model. We also performed heterogeneity and publication bias analyses.
  
  
  RESULTS
  Nine studies including 198 follicular thyroid cancer patients and 268 controls were considered eligible. The frequency of Pax8-PPARγ1 rearrangement was significantly higher in the follicular thyroid cancer group than in the control group, with a pooled OR of 6.63 (95%CI=3.50-12.7). In addition, through subgroup analysis, the OR between Pax8-PPARγ1 rearrangement and follicular thyroid cancer was 6.04 (95%CI = 3.18-11.5) when using benign tumor tissues as controls. The OR for the method subgroup was 9.99 (95% CI =4.86-20.5) in the RT-PCR.
  
  
  CONCLUSIONS
  The final results demonstrated that Pax8-PPARγ1 rearrangement has significant association with follicular thyroid cancer.
authors: Undergraduate of School of Public Health, Hebei Medical University, China E-mail : liuweihebmu@hebmu.edu.cn, bashantree@163.com.
authors: Hang-Yu
authors: HY
authors: Li
authors: Zhi-Hao
authors: ZH
authors: Xie
authors: Cong-Hui
authors: CH
authors: Xu
authors: Mei-Ling
authors: ML
authors: Pu
authors: Zi-Yan
authors: ZY
authors: Chen
authors: Miao
authors: M
authors: Yu
authors: Heng-Shu
authors: HS
authors: Wang
authors: Chen-Ming
authors: CM
authors: Zhou
authors: Chao-Yu
authors: CY
authors: Pu
authors: Wei
authors: W
authors: Liu
mesh_terms: D018263:Adenocarcinoma, Follicular / Q000235:genetics*; D016022:Case-Control Studies; D015321:Gene Rearrangement; D020022:Genetic Predisposition to Disease; D006801:Humans; D000072636:PAX8 Transcription Factor / Q000235:genetics*; D047495:PPAR gamma / Q000235:genetics*; D011379:Prognosis; D012307:Risk Factors
chemical_list: D000072636:PAX8 Transcription Factor; C083325:PAX8 protein, human; D047495:PPAR gamma