title: Clinical observation of laser ablation combined with chemotherapy in postoperative colorectal cancers with liver metastasis.
abstract: BACKGROUND
  This study is to evaluate the efficacy and adverse reaction of a combination therapy of chemotherapy and laser thermal ablation (LTA) on liver metastases from colorectal cancer.
  
  
  METHODS
  Eighty-five cases colorectal cancer liver metastases were assigned to the treatment group (43 cases) and to the control group (42 cases). The treatment group patients received LTA combined with FOLFIRI regimen chemotherapy, and the control group patients only received FOLFIRI regimen chemotherapy. The curative effects, the survival rate and adverse reaction of the two groups were observed and evaluated.
  
  
  RESULTS
  Response rate was 53.4% in the treatment group and 38.1% in the control group (P>0.05); disease control rate in the treatment group was 79.1%, higher than 64.3% in control group with significant difference (P<0.01); median progression free survival was 11.8 months in treatment group and 6.8 months in control group (P<0.01); The median overall survival time was 19.1 months in treatment group and 14.9 months in control group (P<0.05). Among the 113 lesions receiving LTA, 104 lesions (92%) were completely destroyed. The main complications of LTA were fever and local pain. The adverse effects between both groups showed no difference.
  
  
  CONCLUSIONS
  LTA in combination with chemotherapy of colorectal carcinoma liver metastases is effective and well-tolerated.
authors: Department of Oncology, Affiliated Jiangyin Hospital of Southeast University Medical College, Jiangyin, China.
authors: Deng
authors: D
authors: Lichun
authors: Department of Ultrasound, Affiliated Jiangyin Hospital of Southeast University Medical College, Jiangyin, China - Zou_dazhong@163.com.
authors: Zou
authors: Z
authors: Dazhong
authors: Department of Oncology, Affiliated Jiangyin Hospital of Southeast University Medical College, Jiangyin, China.
authors: Shen
authors: S
authors: Wei Sheng
authors: Department of Oncology, Affiliated Jiangyin Hospital of Southeast University Medical College, Jiangyin, China.
authors: Liu
authors: L
authors: Xiongwei
authors: Department of Ultrasound, Affiliated Jiangyin Hospital of Southeast University Medical College, Jiangyin, China.
authors: Sheng
authors: S
authors: Huaming
authors: Department of Ultrasound, Affiliated Jiangyin Hospital of Southeast University Medical College, Jiangyin, China.
authors: Xi
authors: X
authors: Lei
authors: Department of Ultrasound, Affiliated Jiangyin Hospital of Southeast University Medical College, Jiangyin, China.
authors: Zeng
authors: Z
authors: Jie
authors: Department of Oncology, Affiliated Jiangyin Hospital of Southeast University Medical College, Jiangyin, China.
authors: Cao
authors: C
authors: Xiangming
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002277:Carcinoma / Q000401:mortality / Q000556:secondary / Q000628:therapy*; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D053685:Laser Therapy / Q000379:methods; D008113:Liver Neoplasms / Q000401:mortality / Q000556:secondary / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011182:Postoperative Care; D016896:Treatment Outcome