title: Performance of Gadoxetic Acid-Enhanced Liver Magnetic Resonance Imaging for Predicting Patient Eligibility for Liver Transplantation Based on the Milan Criteria.
abstract: OBJECTIVE
  This study aimed to evaluate the accuracy of gadoxetic acid-enhanced magnetic resonance imaging (Gd-EOB-MRI) in predicting eligibility for liver transplantation in patients with hepatocellular carcinoma (HCC) based on Milan criteria (MC).
  
  
  METHODS
  We reviewed Gd-EOB-MRI of 44 patients who underwent liver transplantation for HCC with cirrhosis for the presence/size of HCCs, vascular invasion, and transplant eligibility based on MC. Hepatocellular carcinoma was diagnosed based on conventional radiological hallmarks (arterial enhancement and washout) or the modified criteria.
  
  
  RESULTS
  Among 44 patients, 16 was beyond MC. Sensitivity, specificity, and accuracy of conventional radiological hallmark and the modified criteria for predicting eligibility by MC were 31.3%, 96.3%, and 72.7%, and 68.8%, 96.3%, and 86.4%, respectively.
  
  
  CONCLUSIONS
  Gd-EOB-MRI showed high specificity but poor sensitivity for assessing transplant eligibility based on MC when adopting the conventional radiological hallmarks of HCC. Our modified criteria showed significantly better sensitivity and accuracy than the conventional radiological hallmarks.
authors: From the *Department of Radiology, Seoul St Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul; †Department of Radiology, Daejeon St Mary's Hospital, College of Medicine, The Catholic University of Korea, Daejeon; and Departments of ‡Hospital Pathology, and §Surgery, Seoul St Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors: Hwi Young
authors: HY
authors: Jang
authors: Joon-Il
authors: JI
authors: Choi
authors: Young Joon
authors: YJ
authors: Lee
authors: Michael Yong
authors: MY
authors: Park
authors: Dong Myung
authors: DM
authors: Yeo
authors: Sung Eun
authors: SE
authors: Rha
authors: Eun Sun
authors: ES
authors: Jung
authors: Young Kyoung
authors: YK
authors: You
authors: Dong Goo
authors: DG
authors: Kim
authors: Jae Young
authors: JY
authors: Byun
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D003287:Contrast Media; D004608:Eligibility Determination / Q000379:methods / Q000592:standards*; D005260:Female; D019786:Gadolinium DTPA; D019983:Guideline Adherence / Q000592:standards; D006801:Humans; D007089:Image Enhancement / Q000379:methods / Q000592:standards; D038622:Internationality; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D016031:Liver Transplantation / Q000592:standards*; D008279:Magnetic Resonance Imaging / Q000379:methods / Q000592:standards*; D008297:Male; D008875:Middle Aged; D018579:Patient Selection; D017410:Practice Guidelines as Topic; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media; C073590:gadolinium ethoxybenzyl DTPA; D019786:Gadolinium DTPA