title: Lutein, a carotenoid, suppresses osteoclastic bone resorption and stimulates bone formation in cultures.
abstract: Lutein, a member of the xanthophyll family of carotenoids, suppressed IL-1-induced osteoclast differentiation and bone resorption. The survival of mature osteoclasts was also suppressed by lutein in cultures. When lutein was added to the cultures of osteoblasts, lutein enhanced the formation of mineralized bone nodules by elevating BMP2 expression and inhibiting sclerostin expression. Lutein may be beneficial for bone health.
authors: a Department of Biotechnology and Life Science , Tokyo University of Agriculture and Technology , Tokyo , Japan.|b Institute of Global Innovation Research , Tokyo University of Agriculture and Technology , Tokyo , Japan.
authors: Tsukasa
authors: T
authors: Tominari
authors: a Department of Biotechnology and Life Science , Tokyo University of Agriculture and Technology , Tokyo , Japan.
authors: Chiho
authors: C
authors: Matsumoto
authors: a Department of Biotechnology and Life Science , Tokyo University of Agriculture and Technology , Tokyo , Japan.
authors: Kenta
authors: K
authors: Watanabe
authors: a Department of Biotechnology and Life Science , Tokyo University of Agriculture and Technology , Tokyo , Japan.
authors: Michiko
authors: M
authors: Hirata
authors: b Institute of Global Innovation Research , Tokyo University of Agriculture and Technology , Tokyo , Japan.|c Institute of Crop Science and Resource Conservation , University of Bonn , Bonn , Germany.
authors: Florian M W
authors: FM
authors: Grundler
authors: a Department of Biotechnology and Life Science , Tokyo University of Agriculture and Technology , Tokyo , Japan.|b Institute of Global Innovation Research , Tokyo University of Agriculture and Technology , Tokyo , Japan.
authors: Masaki
authors: M
authors: Inada
authors: a Department of Biotechnology and Life Science , Tokyo University of Agriculture and Technology , Tokyo , Japan.|b Institute of Global Innovation Research , Tokyo University of Agriculture and Technology , Tokyo , Japan.
authors: Chisato
authors: C
authors: Miyaura
mesh_terms: D000818:Animals; D055396:Bone Morphogenetic Protein 2 / Q000378:metabolism; D001862:Bone Resorption / Q000188:drug therapy*; D002478:Cells, Cultured; D005786:Gene Expression Regulation / Q000187:drug effects; D014975:Lutein / Q000494:pharmacology* / Q000627:therapeutic use; D051379:Mice; D010010:Osteoclasts / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D010012:Osteogenesis / Q000187:drug effects*
chemical_list: C525719:Bmp2 protein, mouse; D055396:Bone Morphogenetic Protein 2; D014975:Lutein
keywords: bone formation; bone resorption; xanthophyll family of carotenoids