title: Functionalization of nanostructures for antibiotic improvement: an interdisciplinary approach.
abstract: The resistance of infectious bacteria to current antibiotics is a worldwide problem caused, partially, by the overuse of antimicrobials. The use of nanotechnology as an innovative tool against bacterial infections provides a range of methodologies to redesign old antibiotics for novel and remarkable new strategies. Thus, functionalized antibiotics present structures with improved bioavailability, low toxicity and specificity to bacterial membrane. In this context, this review will describe the use of nanotechnology as an innovative tool to functionalize antibiotics. In addition, the importance of the interdisciplinary context to understand, develop and apply these systems as an innovative tool for drug development and improvement is discussed.
authors: Centro de Análises Proteômicas e Bioquímicas, Pós-Graduação em Ciências Genômicas e Biotecnologia, Universidade Católica de Brasília, Brasília, DF, Brasil.
authors: Acm
authors: A
authors: Saúde
authors: Centro de Análises Proteômicas e Bioquímicas, Pós-Graduação em Ciências Genômicas e Biotecnologia, Universidade Católica de Brasília, Brasília, DF, Brasil.|Universidade de Brasília - UNB. Campus Universitário Darcy Ribeiro, S/N - Asa Norte - CEP: 70790-160 Brasília, DF, Brasil.|Universidade Federal de Juiz de Fora - UFJF. Campus Universitário, Bairro São Pedro - CEP: 36036-900 - Juiz de Fora, MG, Brasil.|S-Inova Biotech, Pós-Graduação em Biotecnologia, Universidade Católica Dom Bosco - UCDB. Av. Tamandaré, 6000, Jardim Seminário - CEP: 79117-900 Campo Grande, MS, Brasil.
authors: O L
authors: OL
authors: Franco
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001424:Bacterial Infections / Q000188:drug therapy*; D016503:Drug Delivery Systems; D006801:Humans; D049329:Nanostructures; D036103:Nanotechnology
chemical_list: D000900:Anti-Bacterial Agents
keywords: antibiotics; antimicrobial peptides; bacteria and nanotechnology; drug development; functionalization; interdisciplinary; nanoparticles; physical–chemical; polymers