title: Manipulation of viral infection by deubiquitinating enzymes: new players in host-virus interactions.
abstract: Ubiquitination regulates gene expression post-translationally through the well-characterized ubiquitin system, which has been clearly established to have important functions in the regulation of many intracellular biological activities. Being obligate intracellular microbes, viruses inevitably co-opt this conserved host cytosolic machinery to accomplish their own life cycle, from entry into host cells to the release of progeny viral particles. Deubiquitinating enzymes (DUBs) remove ubiquitins from target proteins to reverse the modification of ubiquitination, and thusly affect a great number of signaling pathways, as well as viral infections. This review presents what is known about how viruses bypass or employ DUBs to evade host immune defenses and discusses new therapeutic strategies targeting DUBs for diseases treatment.
authors: Department of Laboratory Medicine, the Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu 213003, PR China.
authors: Zhiwen
authors: Z
authors: Gu
authors: Department of Laboratory Medicine, the Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu 213003, PR China.
authors: Weifeng
authors: W
authors: Shi
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000276:immunology / Q000378:metabolism; D017209:Apoptosis; D000072017:Deubiquitinating Enzymes / Q000037:antagonists & inhibitors / Q000378:metabolism* / Q000502:physiology*; D054884:Host-Pathogen Interactions / Q000276:immunology* / Q000502:physiology*; D006801:Humans; D007113:Immunity, Innate / Q000187:drug effects; D058990:Molecular Targeted Therapy; D011499:Protein Processing, Post-Translational; D012328:RNA Viruses / Q000378:metabolism; D015398:Signal Transduction; D054875:Ubiquitination / Q000502:physiology; D014452:Ubiquitins / Q000378:metabolism; D014764:Viral Proteins / Q000378:metabolism; D014777:Virus Diseases / Q000188:drug therapy / Q000378:metabolism*; D014780:Viruses
chemical_list: D000998:Antiviral Agents; D014452:Ubiquitins; D014764:Viral Proteins; D000072017:Deubiquitinating Enzymes
keywords: deubiquitinase inhibitors; deubiquitinating enzymes; post-translational modification; ubiquitin system; viruses