title: Radiosynthesis of SPECT tracers via a copper mediated123I iodination of (hetero)aryl boron reagents.
abstract: A general method for the copper mediated nucleophilic123I-iodination of (hetero)aryl boronic esters and acids has been developed. The broad substrate scope of this radiosynthetic approach allows access to [123I]DPA-713, [123I]IMPY, [123I]MIBG and [123I]IPEB that are four commonly used SPECT radiotracers. Our results infer that aryl boronic reagents can now be employed as common precursors for both fluorine-18 and iodine-123 radiolabelling.
authors: Chemistry Research Laboratory, Department of Chemistry, Oxford University, OX1 3TA, UK. veronique.gouverneur@chem.ox.ac.uk.
authors: Thomas C
authors: TC
authors: Wilson
authors: Chemistry Research Laboratory, Department of Chemistry, Oxford University, OX1 3TA, UK. veronique.gouverneur@chem.ox.ac.uk.
authors: Greg
authors: G
authors: McSweeney
authors: Chemistry Research Laboratory, Department of Chemistry, Oxford University, OX1 3TA, UK. veronique.gouverneur@chem.ox.ac.uk.
authors: Sean
authors: S
authors: Preshlock
authors: Chemistry Research Laboratory, Department of Chemistry, Oxford University, OX1 3TA, UK. veronique.gouverneur@chem.ox.ac.uk.
authors: Stefan
authors: S
authors: Verhoog
authors: Chemistry Research Laboratory, Department of Chemistry, Oxford University, OX1 3TA, UK. veronique.gouverneur@chem.ox.ac.uk and Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, D-45470 Mülheim an der Ruhr, Germany.
authors: Matthew
authors: M
authors: Tredwell
authors: Chemistry Research Laboratory, Department of Chemistry, Oxford University, OX1 3TA, UK. veronique.gouverneur@chem.ox.ac.uk and Normandie University, UNICAEN, CERMN, F-14032 Caen, France.
authors: Thomas
authors: T
authors: Cailly
authors: Chemistry Research Laboratory, Department of Chemistry, Oxford University, OX1 3TA, UK. veronique.gouverneur@chem.ox.ac.uk.
authors: Véronique
authors: V
authors: Gouverneur