title: Successful Object Encoding Induces Increased Directed Connectivity in Presymptomatic Early-Onset Alzheimer's Disease.
abstract: Recent studies report increases in neural activity in brain regions critical to episodic memory at preclinical stages of Alzheimer's disease (AD). Although electroencephalography (EEG) is widely used in AD studies, given its non-invasiveness and low cost, there is a need to translate the findings in other neuroimaging methods to EEG.
  
  
  
  To examine how the previous findings using functional magnetic resonance imaging (fMRI) at preclinical stage in presenilin-1 E280A mutation carriers could be assessed and extended, using EEG and a connectivity approach.
  
  
  
  EEG signals were acquired during resting and encoding in 30 normal cognitive young subjects, from an autosomal dominant early-onset AD kindred from Antioquia, Colombia. Regions of the brain previously reported as hyperactive were used for connectivity analysis.
  
  
  
  Mutation carriers exhibited increasing connectivity at analyzed regions. Among them, the right precuneus exhibited the highest changes in connectivity.
  
  
  
  Increased connectivity in hyperactive cerebral regions is seen in individuals, genetically-determined to develop AD, at preclinical stage. The use of a connectivity approach and a widely available neuroimaging technique opens the possibility to increase the use of EEG in early detection of preclinical AD.
authors: Bioinstrumentation and Clinical Engineering Research Group, Bioengineering Program, Universidad de Antioquia UdeA, Calle 70 No. 52-21, Medellín, Colombia.
authors: John Fredy
authors: JF
authors: Ochoa
authors: Department of Automatic Control (ESAII), Biomedical Engineering Research Center (CREB), Universitat Politènica de Catalunya (UPC), Barcelona, Spain.|Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Spain.
authors: Joan Francesc
authors: JF
authors: Alonso
authors: Bioinstrumentation and Clinical Engineering Research Group, Bioengineering Program, Universidad de Antioquia UdeA, Calle 70 No. 52-21, Medellín, Colombia.
authors: Jon Edinson
authors: JE
authors: Duque
authors: Neuroscience Group of Antioquia, Medical School, Universidad de Antioquia UdeA, Calle 70 No. 52-21, Medellín, Colombia.|Neuropsychology and Behavior group, Medical School, Universidad de Antioquia UdeA, Calle 70 No. 52-21, Medellín, Colombia.
authors: Carlos Andrés
authors: CA
authors: Tobón
authors: Department of Automatic Control (ESAII), Biomedical Engineering Research Center (CREB), Universitat Politènica de Catalunya (UPC), Barcelona, Spain.|Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Spain.
authors: Miguel Angel
authors: MA
authors: Mañanas
authors: Neuroscience Group of Antioquia, Medical School, Universidad de Antioquia UdeA, Calle 70 No. 52-21, Medellín, Colombia.
authors: Francisco
authors: F
authors: Lopera
authors: Bioinstrumentation and Clinical Engineering Research Group, Bioengineering Program, Universidad de Antioquia UdeA, Calle 70 No. 52-21, Medellín, Colombia.
authors: Alher Mauricio
authors: AM
authors: Hernández
mesh_terms: D000328:Adult; D000544:Alzheimer Disease / Q000453:epidemiology / Q000235:genetics / Q000503:physiopathology* / Q000523:psychology*; D058070:Asymptomatic Diseases / Q000453:epidemiology / Q000523:psychology; D001921:Brain / Q000473:pathology* / Q000503:physiopathology; D001931:Brain Mapping; D003105:Colombia / Q000453:epidemiology; D038524:Diffusion Magnetic Resonance Imaging; D004569:Electroencephalography; D019277:Entropy; D005260:Female; D007839:Functional Laterality; D006801:Humans; D008297:Male; D061212:Memory, Episodic; D009154:Mutation / Q000235:genetics; D009434:Neural Pathways / Q000502:physiology*; D009483:Neuropsychological Tests; D010775:Photic Stimulation; D053764:Presenilin-1 / Q000235:genetics; D055815:Young Adult
chemical_list: C508853:PSEN1 protein, human; D053764:Presenilin-1
keywords: Alzheimer’s disease; autosomal-dominant; electroencephalography; functional neuroimaging; memory encoding; presenilin-1