title: Plasma miR-19b and miR-183 as Potential Biomarkers of Lung Cancer.
abstract: Lung cancer is a complex disease that often manifests at the point when treatment is not effective. Introduction of blood-based complementary diagnostics using molecular markers may enhance early detection of this disease and help reduce the burden of lung cancer. Here we evaluated the diagnostic potential of seven plasma miRNA biomarkers (miR-21, -19b, -126, -25, -205, -183, -125b) by quantitative reverse transcription PCR. Influence clinical and demographical characteristics, including age, tumor stage and cancer subtype on miRNA levels was investigated. Four miRNAs were significantly dysregulated (miR-19b, -21, -25, -183) in lung cancer patients. Combination of miR-19b and miR-183 provided detection of lung cancer with 94.7% sensitivity and 95.2% specificity (AUC = 0.990). Thus, miRNAs have shown the potential to discriminate histological subtypes of lung cancer and reliably distinguish lung cancer patients from healthy individuals.
authors: Institute of Chemical Biology and Fundamental Medicine of SB RAS, Novosibirsk, Russia.|Novosibirsk Research Institute of Circulation Pathology of Academician E.N. Meshalkin, Novosibirsk, Russia.
authors: Ivan A
authors: http://orcid.org/0000-0001-9101-2207
authors: IA
authors: Zaporozhchenko
authors: Institute of Chemical Biology and Fundamental Medicine of SB RAS, Novosibirsk, Russia.|Novosibirsk Research Institute of Circulation Pathology of Academician E.N. Meshalkin, Novosibirsk, Russia.
authors: Evgeny S
authors: ES
authors: Morozkin
authors: Institute of Chemical Biology and Fundamental Medicine of SB RAS, Novosibirsk, Russia.
authors: Tatyana E
authors: TE
authors: Skvortsova
authors: Tomsk Cancer Research Institute of SB RAMS, Tomsk, Russia.|National Research Tomsk Polytechnic University, Tomsk, Russia.
authors: Anastasia A
authors: AA
authors: Ponomaryova
authors: Institute of Chemical Biology and Fundamental Medicine of SB RAS, Novosibirsk, Russia.
authors: Elena Yu
authors: EY
authors: Rykova
authors: Tomsk Cancer Research Institute of SB RAMS, Tomsk, Russia.|National Research Tomsk State University, Tomsk, Russia.
authors: Nadezhda V
authors: NV
authors: Cherdyntseva
authors: Novosibirsk Research Institute of Circulation Pathology of Academician E.N. Meshalkin, Novosibirsk, Russia.
authors: Evgeny S
authors: ES
authors: Polovnikov
authors: Novosibirsk Research Institute of Circulation Pathology of Academician E.N. Meshalkin, Novosibirsk, Russia.
authors: Oksana A
authors: OA
authors: Pashkovskaya
authors: Novosibirsk Research Institute of Circulation Pathology of Academician E.N. Meshalkin, Novosibirsk, Russia.
authors: Evgeny A
authors: EA
authors: Pokushalov
authors: Institute of Chemical Biology and Fundamental Medicine of SB RAS, Novosibirsk, Russia.
authors: Valentin V
authors: VV
authors: Vlassov
authors: Institute of Chemical Biology and Fundamental Medicine of SB RAS, Novosibirsk, Russia.|Novosibirsk Research Institute of Circulation Pathology of Academician E.N. Meshalkin, Novosibirsk, Russia.
authors: Pavel P
authors: PP
authors: Laktionov
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000097:blood*; D008875:Middle Aged; D012680:Sensitivity and Specificity
chemical_list: D014408:Biomarkers, Tumor; C533449:MIRN183 microRNA, human; C549214:MIRN19A microRNA, human; D035683:MicroRNAs