title: The correlation of the platelet-to-lymphocyte ratio with the severity of stenosis and stroke in patients with carotid arterial disease.
abstract: Objectives Platelet-to-lymphocyte ratio is a novel biomarker, recently shown to be correlated with atherosclerotic inflammation. This study investigated the role of platelet-to-lymphocyte ratio in patients with carotid artery stenosis and stroke. Methods Patients, who underwent carotid angiography with Multiple Detector Computed Tomography Angiography at our hospital, were retrospectively screened. Patients enrolled were divided into three groups based on the platelet-to-lymphocyte ratio. Patients with a platelet-to-lymphocyte ratio value between 55.0 and 106.71 were assigned to Group I, patients with a platelet-to-lymphocyte ratio value between 106.79 and 160.61 were assigned to Group II and patients with a platelet-to-lymphocyte ratio value between 162.96 and 619.61 were assigned to Group III. The carotid arterial stenosis calculated was classified as per the criteria of North American Symptomatic Carotid Endarterectomy Trial. Results One hundred fifty patients were included in our trial (mean age 61.9 ± 13.1 with 104 males). The rate of carotid arterial stenosis was detected to be higher in patients with a high platelet-to-lymphocyte ratio value (p = 0.010). Additionally, the platelet-to-lymphocyte ratio was positively correlated with the carotid arterial stenosis percentage (r = 0.250, p = 0.002). In the multi-variate regression analysis, platelet-to-lymphocyte ratio was detected to be an independent variable with respect to stroke (odd's ratio = 1.012, confidence interval = 1.001-1.024, p = 0.031). Conclusions Increased platelet-to-lymphocyte ratio could be a simple and practical marker of the clinical course in patients with carotid arterial stenosis.
authors: 1 Department of Radiology, Ondokuz Mayis University, Turkey.
authors: Ayşegül
authors: A
authors: İdil Soylu
authors: 1 Department of Radiology, Ondokuz Mayis University, Turkey.
authors: Sümeyra
authors: S
authors: Arıkan Cortcu
authors: 1 Department of Radiology, Ondokuz Mayis University, Turkey.
authors: Fatih
authors: F
authors: Uzunkaya
authors: 1 Department of Radiology, Ondokuz Mayis University, Turkey.
authors: Yunus Oktay
authors: YO
authors: Atalay
authors: 1 Department of Radiology, Ondokuz Mayis University, Turkey.
authors: Tumay
authors: T
authors: Bekçi
authors: 2 Department of Neurology, Ondokuz Mayis University, Turkey.
authors: Levent
authors: L
authors: Güngör
authors: 1 Department of Radiology, Ondokuz Mayis University, Turkey.
authors: Ümit
authors: Ü
authors: Belet
mesh_terms: D000368:Aged; D001792:Blood Platelets; D016893:Carotid Stenosis / Q000097:blood* / Q000150:complications* / Q000000981:diagnostic imaging; D016009:Chi-Square Distribution; D000072226:Computed Tomography Angiography; D005260:Female; D006801:Humans; D016015:Logistic Models; D018655:Lymphocyte Count; D008214:Lymphocytes; D008297:Male; D008875:Middle Aged; D061330:Multidetector Computed Tomography; D015999:Multivariate Analysis; D016017:Odds Ratio; D010976:Platelet Count; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D020521:Stroke / Q000175:diagnosis / Q000209:etiology*
keywords: Platelet-to-lymphocyte ratio; carotid stenosis; stroke