title: Applied investigation of person-specific and context-specific factors on postoperative recovery and clinical outcomes of patients undergoing gastrointestinal cancer surgery: multicentre European study.
abstract: Cancer treatments have greatly advanced over the past two decades causing survival improvements and reduced complications from cancer surgery. However, the cancer diagnosis and the effects of treatment modalities pose a major risk to patients' psychological well-being. Given current interest and emerging evidence about the importance of psychological and social factors on cancer survival and coping with cancer treatments, this study will build and expand research in order to identify key modifiable psychosocial variables that contribute to better physical and mental health following gastrointestinal cancer (GIC) surgery.
  
  
  
  To elucidate the incidence of postoperative psychiatric morbidity within 6 months following GIC surgery. To identify key measurable modifiable preoperative psychological factors that can significantly affect postoperative psychiatric morbidity in patients undergoing surgery for GIC. To clarify the changes seen in a patient's psychological well-being during their treatment pathway for GIC.
  
  
  
  This multicentre study has an observational longitudinal study design. In total, 1000 patients will be screened with a multicomponent psychological questionnaire at four different time points: at diagnosis, preoperatively, 1 and 6 months after surgery. Data from this questionnaire will be linked to postoperative complications including psychiatric morbidity, length of hospital stay and recovery to normal activity.
  
  
  
  NHS Health Research Authority approval was gained on (REC reference 15.LO/1847) for the completion of this study. Multiple platforms will be used for the dissemination of the research data, including international clinical and patient group presentations and publication of research outputs in a high impact clinical journal.
authors: Department of Surgery & Cancer, Imperial College London, London, UK.
authors: Sheraz R
authors: SR
authors: Markar
authors: Department of Surgery & Cancer, Imperial College London, London, UK.
authors: Stella
authors: S
authors: Mavroveli
authors: London Psychometric Laboratory, University College London, London, UK.
authors: Konstantinos V
authors: KV
authors: Petrides
authors: Esophageal and Digestive Tract Surgical Unit, Veneto Institute of Oncology, Padova, Veneto, Italy.
authors: Marco
authors: M
authors: Scarpa
authors: Department of Psychology, University of Lille, Lille, France.
authors: Veronique
authors: V
authors: Christophe
authors: Esophageal and Digestive Tract Surgical Unit, Veneto Institute of Oncology, Padova, Veneto, Italy.
authors: Carlo
authors: C
authors: Castoro
authors: Department of Digestive and Oncology surgery, University Hospital Claude Huriez, Lille, France.
authors: Christophe
authors: C
authors: Mariette
authors: Department of Molecular Medicine & Surgery, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
authors: Pernilla
authors: P
authors: Lagergren
authors: Department of Surgery & Cancer, Imperial College London, London, UK.
authors: George B
authors: GB
authors: Hanna
mesh_terms: D000223:Adaptation, Psychological; D013505:Digestive System Surgical Procedures; D005060:Europe; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000523:psychology* / Q000601:surgery; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D001523:Mental Disorders / Q000209:etiology* / Q000517:prevention & control; D008603:Mental Health; D011183:Postoperative Complications / Q000523:psychology*; D011184:Postoperative Period; D012107:Research Design; D012307:Risk Factors; D011795:Surveys and Questionnaires
keywords: PSYCHIATRY; SURGERY