title: Bruton tyrosine kinase inhibitor ONO/GS-4059: from bench to bedside.
abstract: The Bruton tyrosine kinase (BTK) inhibitor, ibrutinib, has been approved for the treatment of chronic lymphocytic leukemia, mantle cell lymphoma, and Waldenstrom's macroglobulinemia. Acquired resistance to ibrutinib due to BTK C481S mutation has been reported. Mutations in PLCγ2 can also mediate resistance to ibrutinib. Untoward effects due to off-target effects are also disadvantages of ibrutinib. More selective and potent BTK inhibitors (ACP-196, ONO/GS-4059, BGB-3111, CC-292) are being investigated. This review summarized the preclinical research and clinical data of ONO/GS-4059.
authors: Department of Oncology, The first Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
authors: Jingjing
authors: J
authors: Wu
authors: Department of Oncology, The first Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
authors: Mingzhi
authors: M
authors: Zhang
authors: Department of Oncology, The first Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
authors: Delong
authors: D
authors: Liu
mesh_terms: D000077329:Agammaglobulinaemia Tyrosine Kinase; D002986:Clinical Trials as Topic; D019008:Drug Resistance, Neoplasm / Q000187:drug effects*; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology / Q000627:therapeutic use*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000188:drug therapy* / Q000235:genetics; D020522:Lymphoma, Mantle-Cell / Q000188:drug therapy* / Q000235:genetics; D009154:Mutation; D051966:Phospholipase C gamma / Q000235:genetics; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors / Q000235:genetics; D011743:Pyrimidines / Q000494:pharmacology / Q000627:therapeutic use*; D016896:Treatment Outcome; D008258:Waldenstrom Macroglobulinemia / Q000188:drug therapy* / Q000235:genetics
chemical_list: D007093:Imidazoles; D011743:Pyrimidines; D011505:Protein-Tyrosine Kinases; D000077329:Agammaglobulinaemia Tyrosine Kinase; C000625949:BTK protein, human; D051966:Phospholipase C gamma; C000608238:tirabrutinib
keywords: Bruton tyrosine kinase; ONO/GS-4059; ibrutinib