title: The unmet needs: How future technologies will address current limitations of bioresorbable scaffold technology.
abstract: First-generation bioresorbable scaffolds (BRS), represented by the three marked-approved devices (Absorb BVS 1.1, DESolve NX, and DREAMS) have demonstrated, in low to moderate angiographic scenarios, similar efficacy to current generation metallic drug-eluting stents. However, a trend toward more device thrombosis have been observed, especially when the scaffolds are used in off-label situations. Among the main shortcomings of this novel technology, we highlight: (1) Increased strut thickness (≥150 μm) and crossing profile; (2) low resistance to overexpansion; (3) lack of radiopacity, and; (4) special storage requirements. In order to overcome these limitations and improve their acute performance and midterm safety, a dozen of novel BRS are currently under research, in different stages of development. In the present review, we address three of these new technologies, pointing out their innovative features and initial clinical results. © 2016 Wiley Periodicals, Inc.
authors: Instituto Dante Pazzanese de Cardiologia, São Paulo, Brazil. aabizaid@uol.com.br.|Hospital do Coração - Associação do Sanatorio Sírio, São Paulo, Brazil. aabizaid@uol.com.br.|Hospital Israelita Albert Einstein, São Paulo, Brazil. aabizaid@uol.com.br.
authors: Alexandre
authors: A
authors: Abizaid
authors: Instituto Dante Pazzanese de Cardiologia, São Paulo, Brazil.|Hospital do Coração - Associação do Sanatorio Sírio, São Paulo, Brazil.
authors: J
authors: J
authors: Ribamar Costa
mesh_terms: D020341:Absorbable Implants; D003324:Coronary Artery Disease / Q000601:surgery*; D054855:Drug-Eluting Stents; D006801:Humans; D062645:Percutaneous Coronary Intervention / Q000379:methods*; D011474:Prosthesis Design; D054457:Tissue Scaffolds
keywords: bioabsorbable devices/polymers; coronary artery disease; interventional devices/innovation