title: The Etiology and Pathogenesis of Kienböck Disease.
abstract: Kienböck disease is a condition that typically occurs in the "at-risk" patient, in the "at-risk" aspect of the proximal condyle of the "at-risk" lunate. In the active male, repetitive loading causes the stress fracture that commences in the single layer proximal subchondral bone plate. The lunate fracture commences at the point the lunate cantilevers over the edge of the distal radius, and then takes on the shape of the radius. We postulate that the stress fracture violates the parallel veins of the venous subarticular plexus-leading to localized venous hypertension and subsequent ischemia and edema of the fatty marrow. The increased osseous compartment pressure further potentiates the venous obstruction, producing avascular necrosis. If the fracture remains localized, it can heal or settle into a stable configuration, so that the wrist remains functional. Fractures of the subchondral bone plate produce irregularity of the lunate articular surfaces and secondary "kissing lesions" of the lunate facet and capitate, and subsequent degeneration. The lunate collapses when the fracture is comminuted, or there is disruption of the spanning trabeculae or a coronal fracture. The secondary effect of the lunate collapse is proximal migration of the capitate between the volar and dorsal fragments, producing collapse of the entire central column. The proximal carpal row is now unstable, and is similar to scapholunate instability, where the capitate migrates between the scaphoid and lunate. The scaphoid is forced into flexion by the trapezium, however, degeneration of the scaphoid and scaphoid facet only occurs in late disease or following failed surgery. In Kienböck disease, the secondary effects of the collapsing lunate are a "compromised" wrist, including: deformity and collapse of the central column, degeneration of the central column (perilunate) articulations, proximal row instability (i.e., between the central and radial columns), and degeneration of the radial column.
authors: Department of Orthopaedic Surgery, Flinders University, Adelaide, South Australia, Australia.
authors: Gregory Ian
authors: GI
authors: Bain
authors: Department of Orthopaedic Surgery, Flinders University, Adelaide, South Australia, Australia.
authors: Simon Bruce Murdoch
authors: SB
authors: MacLean
authors: Hand and Microsurgery Section, Department of Orthopaedic Surgery, Tan Tock Seng Hospital, Singapore.
authors: Chong Jin
authors: CJ
authors: Yeo
authors: School of Computer Science, Engineering and Mathematics, Flinders University, Adelaide, South Australia, Australia.
authors: Egon
authors: E
authors: Perilli
authors: Uniformed Services University, Bethesda, Maryland; University of North Texas Health Science Center, Fort Worth, Texas.
authors: David M
authors: DM
authors: Lichtman
keywords: Kienböck disease; etiology; lunate; pathogenesis