title: The association between serum ghrelin levels and large-for-gestational-age fetuses in patients with gestational diabetes mellitus.
abstract: We aimed to determine the relationship between serum ghrelin levels and large-for-gestational-age (LGA) fetuses in patients with gestational diabetes mellitus (GDM). A case-control study was conducted in 32 women with GDM and LGA fetuses (GDM + LGA group), 35 women with GDM and appropriate-for-gestational-age (AGA) fetuses (GDM + AGA group), 32 women with normal glucose tolerance (NGT) and LGA fetuses (NGT + LGA group), and 31 women with NGT and AGA fetuses (NGT + AGA group). All participants were recruited at the time of GDM diagnosis between 24 and 30 weeks of pregnancy. Participants also underwent ultrasonographic examinations. Serum ghrelin levels were significantly higher in GDM + LGA and GDM + AGA groups than in the NGT + AGA group. In the univariate model, biparietal diameter, head circumference, abdominal circumference (AC), femur length and ghrelin values were significant predictors of LGA fetuses. In the multivariate model, only AC remained as a predictor of LGA fetuses.
authors: a Department of Obstetrics and Gynecology , School of Medicine, Akdeniz University , Antalya , Turkey.
authors: Hülya Ayık
authors: HA
authors: Aydın
authors: b Department of Obstetrics and Gynecology and.
authors: Aysel
authors: A
authors: Derbent Uysal
authors: b Department of Obstetrics and Gynecology and.
authors: Onur
authors: O
authors: Erol
authors: c Department of Biochemistry , Antalya Training and Research Hospital , Antalya , Turkey.
authors: Hamit Yaşar
authors: HY
authors: Ellidağ
authors: c Department of Biochemistry , Antalya Training and Research Hospital , Antalya , Turkey.
authors: Aslı
authors: A
authors: Bayındır
authors: c Department of Biochemistry , Antalya Training and Research Hospital , Antalya , Turkey.
authors: Necat
authors: N
authors: Yılmaz
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D016640:Diabetes, Gestational / Q000097:blood*; D005260:Female; D005320:Fetal Macrosomia / Q000000981:diagnostic imaging* / Q000209:etiology; D005865:Gestational Age; D054439:Ghrelin / Q000097:blood*; D006801:Humans; D011247:Pregnancy; D016216:Ultrasonography, Prenatal
chemical_list: D054439:Ghrelin
keywords: Gestational diabetes mellitus; ghrelin; glucose intolerance; large-for-gestational-age fetus