title: Atrial fibrillation in heart failure with preserved ejection fraction: Insights into mechanisms and therapeutics.
abstract: Atrial fibrillation (AF) and heart failure (HF) often coexist, and the outcomes of patients who have both AF and HF are considerably worse than those with either condition in isolation. Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous clinical entity and accounts for approximately one-half of current HF. At least one-third of patients with HFpEF are burdened by comorbid AF. The current understanding of the relationship between AF and HFpEF is limited, but the clinical implications are potentially important. In this review, we explore 1) the pathogenesis that drives AF and HFpEF to coexist; 2) pharmacologic therapies that may attenuate the impact of AF in HFpEF; and 3) future directions in the management of this complex syndrome.
authors: Brigham and Women's Heart & Vascular Center and Harvard Medical School, Boston, MA, United States.
authors: Ravi B
authors: RB
authors: Patel
authors: Brigham and Women's Heart & Vascular Center and Harvard Medical School, Boston, MA, United States. Electronic address: mvaduganathan@partners.org.
authors: Muthiah
authors: M
authors: Vaduganathan
authors: Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, United States.
authors: Sanjiv J
authors: SJ
authors: Shah
authors: Division of Cardiology, Stony Brook University, Stony Brook, NY, United States.
authors: Javed
authors: J
authors: Butler
mesh_terms: D000818:Animals; D000925:Anticoagulants / Q000627:therapeutic use; D001281:Atrial Fibrillation / Q000188:drug therapy / Q000503:physiopathology / Q000517:prevention & control / Q000601:surgery; D017115:Catheter Ablation; D006325:Heart Atria / Q000503:physiopathology; D006333:Heart Failure / Q000188:drug therapy / Q000503:physiopathology / Q000601:surgery; D006801:Humans; D013318:Stroke Volume
chemical_list: D000925:Anticoagulants
keywords: Atrial fibrillation; Heart failure; Mechanisms; Therapeutics