title: Phytochemical Screening and Antinociceptive and Antidiarrheal Activities of Hydromethanol and Petroleum Benzene Extract ofMicrocos paniculataBarks.
abstract: Introduction.Microcos paniculatais traditionally used for treating diarrhea, wounds, cold, fever, hepatitis, dyspepsia, and heat stroke.Objective. To investigate the qualitative phytochemical constituents of hydromethanol (HMPB) and petroleum benzene extract ofMicrocos paniculatabarks (PBMPB) and to evaluate their antinociceptive and antidiarrheal activities.Methods. Phytochemical constituents and antinociceptive and antidiarrheal activities were determined and evaluated by different tests such as Molisch's, Fehling's, Mayer's, Wagner's, Dragendorff's, frothing, FeCl3, alkali, Pew's, and Salkowski's test, general test of glycosides, Baljet and NH4OH test, formalin-induced paw licking, acetic acid-induced writhing, tail immersion, and hot plate tests, and castor oil and MgSO4induced diarrheal tests.Results. These extracts revealed the presence of saponins, flavonoids, and triterpenoids and significantly (⁎P< 0.05, versus control) reduced paw licking and abdominal writhing of mice. At 30 min after their administration, PBMPB revealed significant increase in latency (⁎P< 0.05, versus control) in tail immersion test. In hot plate test, HMPB and PBMPB 200 mg/kg showed significant increase in response latency (⁎P< 0.05, versus control) at 30 min after their administration. Moreover, both extracts significantly (⁎P< 0.05, versus control) inhibited percentage of diarrhea in antidiarrheal models.Conclusion.Study results indicate thatM.paniculatamay provide a source of plant compounds with antinociceptive and antidiarrheal activities.
authors: Department of Pharmacy, Stamford University Bangladesh, 51 Siddeswari Road, Dhaka 1217, Bangladesh.
authors: Rafath Ara
authors: RA
authors: Moushome
authors: Department of Pharmacy, Stamford University Bangladesh, 51 Siddeswari Road, Dhaka 1217, Bangladesh.
authors: Mst Irin
authors: MI
authors: Akter
authors: Department of Pharmacy, Jessore University of Science & Technology, Jessore, Bangladesh.
authors: Md Abdullah
authors: 0000-0003-3835-4800
authors: MA
authors: Aziz
mesh_terms: D000700:Analgesics / Q000008:administration & dosage* / Q000138:chemical synthesis; D000818:Animals; D000930:Antidiarrheals / Q000008:administration & dosage* / Q000138:chemical synthesis; D001554:Benzene / Q000737:chemistry; D003967:Diarrhea / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D004353:Drug Evaluation, Preclinical / Q000379:methods; D005260:Female; D008297:Male; D019660:Malvaceae / Q000737:chemistry; D000432:Methanol / Q000737:chemistry*; D051379:Mice; D010146:Pain / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D010147:Pain Measurement / Q000187:drug effects; D010578:Petroleum; D008517:Phytotherapy / Q000379:methods; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000008:administration & dosage* / Q000737:chemistry; D016896:Treatment Outcome; D014867:Water / Q000737:chemistry
chemical_list: D000700:Analgesics; D000930:Antidiarrheals; D010578:Petroleum; D010936:Plant Extracts; D014867:Water; D001554:Benzene; D000432:Methanol