title: Evaluation of Paraoxonase, Arylesterase and Malondialdehyde Levels in Schizophrenia Patients Taking Typical, Atypical and Combined Antipsychotic Treatment.
abstract: OBJECTIVE
  Human serum paraoxonase (PON1) prevents lipids from peroxidation and functions as an antioxidant mechanism. Malonyldialdehyde (MDA) is the final product of lipid peroxidation and can be used as an indicator of oxidative stress. The aim of this study was to investigate PON1, MDA, and arylesterase (ARY) levels in schizophrenic patients who are taking typical, atypical, or combined (typical and atypical) antipsychotic drug treatment, with respect to those of healthy controls.
  
  
  METHODS
  We evaluated 41 patients (11 taking typical antipsychotics, 19 taking atypical antipsychotics, 11 taking combined antipsychotics) and 43 healthy controls.
  
  
  RESULTS
  MDA levels were higher in schizophrenic patients taking typical antipsychotics compared with healthy controls (p=0.001). ARY levels were higher in patients taking atypical antipsychotics compared with healthy controls (p=0.005). PON1 activity was similar in all groups.
  
  
  CONCLUSIONS
  Our results indicate that treatment with typical antipsychotic drugs could be related to increased MDA levels; and antipsychotic medication may increase PON1 levels in schizophrenic patients.
authors: Department of Psychiatry, Faculty of Medicine, Dicle University, Diyarbakir, Turkey.
authors: Mehmet
authors: M
authors: Güneş
authors: Department of Psychiatry, State Hospital of Afsin, Kahramanmaras, Turkey.
authors: Mehmet Akif
authors: MA
authors: Camkurt
authors: Department of Psychiatry, Faculty of Medicine, Dicle University, Diyarbakir, Turkey.
authors: Mahmut
authors: M
authors: Bulut
authors: Department of Psychiatry, Faculty of Medicine, Dicle University, Diyarbakir, Turkey.
authors: Süleyman
authors: S
authors: Demir
authors: Department of Psychiatry, Faculty of Medicine, Dicle University, Diyarbakir, Turkey.
authors: Aslıhan Okan
authors: AO
authors: İbiloğlu
authors: Department of Psychiatry, Faculty of Medicine, Dicle University, Diyarbakir, Turkey.
authors: Mehmet Cemal
authors: MC
authors: Kaya
authors: Department of Psychiatry, Faculty of Medicine, Dicle University, Diyarbakir, Turkey.
authors: Abdullah
authors: A
authors: Atlı
authors: Department of Biochemistry, Faculty of Medicine, Dicle University, Diyarbakir, Turkey.
authors: İbrahim
authors: İ
authors: Kaplan
authors: Department of Psychiatry, Faculty of Medicine, Dicle University, Diyarbakir, Turkey.
authors: Aytekin
authors: A
authors: Sir
keywords: Antipsychotics; Arylesterase; Malondialdehyde; Paraoxonase; Schizophrenia; Treatment