title: ITPP Treatment of RG2 Glioblastoma in a Rat Model.
abstract: Inositol trispyrophosphate (ITPP) has been shown to reduce tumour growth in different animal cancer models, as well as of human U87 glioma cells grafted onto chick chorioallantoic membrane (CAM). The aim of this study was to establish whether ITPP crosses the blood-brain barrier and whether it halts the growth of RG2 glioblastoma tumour.
  
  
  
  A model comprising of Fischer 344 rats was chosen and RG2 cells were implanted either intracranially, or subcutaneously on the left hind leg, and the animals were treated with ITPP either intraperitoneally, intravenously or both routes combined. Overall survival was then calculated.
  
  
  
  No prolonged survival was seen in animals treated with ITPP. The route of ITPP administration did not affect outcome.
  
  
  
  ITPP had no favourable effect upon survival in our animal model with RG2 glioblastoma tumours in Fischer 344 rats.
authors: The Rausing Laboratory, Division of Neurosurgery, Department of Clinical Sciences Lund, Lund University, Lund, Sweden karolina.fornvik@med.lu.se.
authors: Karolina
authors: K
authors: Förnvik
authors: The Rausing Laboratory, Division of Neurosurgery, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.
authors: Shaian
authors: S
authors: Zolfaghari
authors: The Rausing Laboratory, Division of Neurosurgery, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.
authors: Leif G
authors: LG
authors: Salford
authors: The Rausing Laboratory, Division of Neurosurgery, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.
authors: Henrietta Nittby
authors: HN
authors: Redebrandt
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000188:drug therapy*; D004195:Disease Models, Animal; D005260:Female; D005909:Glioblastoma / Q000188:drug therapy*; D007295:Inositol Phosphates / Q000627:therapeutic use*; D051381:Rats; D011916:Rats, Inbred F344
chemical_list: D007295:Inositol Phosphates; C516441:inositol trispyrophosphate
keywords: Glioblastoma multiforme; RG2; angiogenesis; hypoxia; inositol trispyrophosphate