title: Microparticles to enhance delivery of drugs and growth factors into wound sites.
abstract: Microparticles with controlled size and morphology are of significant interest in the field of drug delivery. Although advanced nanoparticles have been the object of a substantial number of reviews, fewer have focused on microparticles, especially for the delivery of drugs and growth factors to the wound site. Microparticles show distinct advantages, including ease of production and characterization, extended release properties, high drug loading and little concern about the toxicity as compared with the nanosized systems. This review presents an introduction to the pathophysiology of wound healing and provides an overview of some of the recent advances in microparticle-based drugs and growth factors delivery to wound sites.
authors: Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, FI-00014 Helsinki, Finland.|Laboratory of Radiochemistry, Department of Chemistry, University of Helsinki, FI-00014 Helsinki, Finland.
authors: Sanjeev
authors: S
authors: Ranjan
authors: Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, FI-00014 Helsinki, Finland.
authors: Flavia
authors: F
authors: Fontana
authors: Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, FI-00014 Helsinki, Finland.|Department of Pharmacy, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan.
authors: Hanif
authors: H
authors: Ullah
authors: Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, FI-00014 Helsinki, Finland.
authors: Jouni
authors: J
authors: Hirvonen
authors: Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, FI-00014 Helsinki, Finland.
authors: Hélder A
authors: HA
authors: Santos
mesh_terms: D000464:Alginates / Q000008:administration & dosage; D000818:Animals; D048271:Chitosan / Q000008:administration & dosage; D003094:Collagen / Q000008:administration & dosage; D016503:Drug Delivery Systems / Q000379:methods* / Q000639:trends; D020723:Glucuronic Acid / Q000008:administration & dosage; D006603:Hexuronic Acids / Q000008:administration & dosage; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D008055:Lipids / Q000008:administration & dosage; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D011108:Polymers / Q000008:administration & dosage; D014945:Wound Healing / Q000187:drug effects; D014947:Wounds and Injuries / Q000188:drug therapy / Q000378:metabolism*
chemical_list: D000464:Alginates; D006603:Hexuronic Acids; D036341:Intercellular Signaling Peptides and Proteins; D008055:Lipids; D004364:Pharmaceutical Preparations; D011108:Polymers; D020723:Glucuronic Acid; D003094:Collagen; D048271:Chitosan
keywords: drugs; growth factors; microparticles; wound healing