title: Short communication: Hypolipidemic and antiinflammatory effects of fermented Maillard reaction products by Lactobacillus fermentum H9 in an animal model.
abstract: This study examined the effects of Maillard reaction products reacted by casein and lactose (cMRP) and of cMRP fermented by Lactobacillus fermentum H9 (F-cMRP) on hypolipidemic and antiinflammatory effects in rats fed a high-fat and high-cholesterol diet (HD). The HD-fed rats had significantly increased hepatic triglyceride concentrations compared with the rats fed a normal diet. It was shown that treatment with simvastatin, L. fermentum H9 (H9), cMRP, and F-cMRP decreased total triglycerides in the liver compared with the HD group. On histological analysis, a reduction of lipid accumulation in the liver and aortic tissues was observed in the cMRP, F-cMRP, and H9-fed rats. Also, F-cMRP and cMRP reduced intima-media thickness in the HD group. In addition, the H9, cMRP, and F-cMRP treatments significantly reduced the expression levels of ICAM-1 and VCAM-1, but not of MCP-1. In particular, the expressions of ICAM-1 and VCAM-1 were significantly decreased in the F-cMRP group compared with the HD group. These results of the present study suggest that cMRP and F-cMRP in dairy foods could potentially be used to prevent or treat cardiovascular diseases, especially atherosclerosis.
authors: R&D Center, Seoul Dairy Cooperative, Ansan, Kyunggi 425-839, South Korea.
authors: Nam Su
authors: NS
authors: Oh
authors: Division of Biotechnology, College of Life Science and Biotechnology, Korea University, Seoul 136-701, South Korea.
authors: Ji Hoon
authors: JH
authors: Koh
authors: Division of Biotechnology, College of Life Science and Biotechnology, Korea University, Seoul 136-701, South Korea.
authors: Mi Ri
authors: MR
authors: Park
authors: Department of Animal Science and Institute of Milk Genomics, Chonbuk National University, Jeonju, 561-756, Korea.
authors: Younghoon
authors: Y
authors: Kim
authors: Division of Biotechnology, College of Life Science and Biotechnology, Korea University, Seoul 136-701, South Korea. Electronic address: saehkim@korea.ac.kr.
authors: Sae Hun
authors: SH
authors: Kim
mesh_terms: D000818:Animals; D059168:Carotid Intima-Media Thickness; D002784:Cholesterol / Q000378:metabolism; D006937:Hypercholesterolemia; D052197:Limosilactobacillus fermentum; D008099:Liver / Q000378:metabolism; D015416:Maillard Reaction; D051381:Rats; D014280:Triglycerides / Q000378:metabolism
chemical_list: D014280:Triglycerides; D002784:Cholesterol
keywords: Lactobacillus fermentum; Maillard reaction product; hypolipidemic and antiinflammatory effect; rat animal model; reverse transcription-PCR