title: High Prevalence of Hyperhomocysteinemia and Its Association with Target Organ Damage in Chinese Patients with Chronic Kidney Disease.
abstract: Hyperhomocysteinemia (HHcy) is recognized as a risk factor for cardiovascular disease. However, the prevalence of HHcy and its role in association with target organ damage in patients with chronickidney disease (CKD) are not well understood. This cross-sectional study included 1042 CKD patients who were admitted to our hospital. Patients were divided into two groups: hyperhomocysteinemia and normohomocysteinemia. Multivariable linear regression analyses were used to evaluate the association between plasma homocysteine and renal/cardiovascular parameters. The prevalence of HHcy in patients with CKD was 52.78%, and the prevalence in CKD stage 1, stage 2, stage 3, stage 4 and stage 5 patients was 10.73%, 29.22%, 58.71%, 75.23% and 83.75%, respectively. Patients with HHcy had higher incidences of renal damage, left ventricular hypertrophy, left ventricular diastolic dysfunction and abnormal carotid intima-media thickness compared with patients with normohomocysteinemia (p< 0.05), while multivariable linear regression analyses showed plasma homocysteine was only associated with the estimated glomerular filtration rate (eGFR). eGFR, uric acid, albumin, gender, hemoglobin and calcium×phosphate were associated with levels of plasma homocysteine in these CKD patients. The prevalence of HHcy in Chinese patients with CKD was high, and serum homocysteine levels were associated with impaired renal function in these patients.
authors: Division of Nephrology, Department of medicine, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, China. yzchun9@163.com.
authors: Zengchun
authors: Z
authors: Ye
authors: Division of Nephrology, Department of medicine, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, China. kawayiqunzi@163.com.
authors: Qunzi
authors: Q
authors: Zhang
authors: Department of Pathology, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, China. energyan@163.com.
authors: Yan
authors: Y
authors: Li
authors: Division of Nephrology, Department of medicine, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, China. wt770716@163.com.
authors: Cheng
authors: C
authors: Wang
authors: Division of Nephrology, Department of medicine, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, China. zj_ncjx@163.com.
authors: Jun
authors: J
authors: Zhang
authors: Division of Nephrology, Department of medicine, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, China. maxxin_09@126.com.
authors: Xinxin
authors: X
authors: Ma
authors: Division of Nephrology, Department of medicine, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, China. elizapeng10@gmail.com.
authors: Hui
authors: H
authors: Peng
authors: Division of Nephrology, Department of medicine, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, China. lou.tq@163.com.
authors: Tanqi
authors: T
authors: Lou
mesh_terms: D000328:Adult; D002130:Calcium Phosphates / Q000097:blood; D002339:Carotid Arteries / Q000473:pathology; D059168:Carotid Intima-Media Thickness; D003430:Cross-Sectional Studies; D005260:Female; D005919:Glomerular Filtration Rate; D006454:Hemoglobins / Q000032:analysis; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D020138:Hyperhomocysteinemia / Q000097:blood* / Q000150:complications / Q000453:epidemiology / Q000503:physiopathology; D017379:Hypertrophy, Left Ventricular / Q000209:etiology; D015994:Incidence; D007668:Kidney / Q000503:physiopathology; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D051436:Renal Insufficiency, Chronic / Q000097:blood* / Q000150:complications / Q000473:pathology / Q000503:physiopathology; D012307:Risk Factors; D012709:Serum Albumin / Q000032:analysis; D012737:Sex Factors; D014527:Uric Acid / Q000097:blood; D018487:Ventricular Dysfunction, Left / Q000209:etiology
chemical_list: D002130:Calcium Phosphates; D006454:Hemoglobins; D012709:Serum Albumin; D006710:Homocysteine; D014527:Uric Acid; C020243:calcium phosphate
keywords: chronic kidney disease; hyperhomocysteinemia