title: Nonspecific periaqueductal gray lesions on T2WI in episodic migraine.
abstract: BACKGROUND
  The specific periaqueductal gray (PAG) lesions with migraine-like headache were easily identified on conventional MR images in clinical practice, and the aim of this study is to investigate the nonspecific periaqueductal gray (PAG) lesions in episodic migraine (EM) patients based on T2 weighted imaging (T2WI).
  
  
  METHODS
  T2WI images were obtained from 18 EM patients and 18 normal controls (NC) on 3.0 T MR system. The images were observed by two experienced radiologists, and the lesions were identified on T2WI by consensus by 2 experienced neuroradiologists blinded to the patient identity. Chi-Square test was performed for the significance test.
  
  
  RESULTS
  Ring-like hyperintensity lesions (HILs) around the PAG region were observed in 14 EM patients and in 5 NCs on T2WI. Four EM patients and 13 NCs were normal in PAG region. The significance was revealed by Chi-Square test (P = 0.003).
  
  
  CONCLUSIONS
  HIL of PAG may be the direct evidence of the EM genesis, and the further structural and functional study should be performed to elucidate the neuromechanism of migraine pathogenesis.
authors: Department of Radiology, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China.|Department of Neurology, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China.
authors: Zhiye
authors: Z
authors: Chen
authors: Department of Neurology, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China.
authors: Xiaoyan
authors: X
authors: Chen
authors: Department of Radiology, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China.
authors: Mengqi
authors: M
authors: Liu
authors: Department of Radiology, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China.
authors: Shuangfeng
authors: S
authors: Liu
authors: Department of Radiology, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China. cjr.malin@vip.163.com.
authors: Lin
authors: L
authors: Ma
authors: Department of Neurology, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China. yusy1963@126.com.
authors: Shengyuan
authors: S
authors: Yu
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000000981:diagnostic imaging*; D010487:Periaqueductal Gray / Q000000981:diagnostic imaging*; D055815:Young Adult
keywords: Episodic migraine; Hyperintensity lesions; Magnetic resonance imaging; Periaqueductal gray