title: Evaluation of the Diagnostic Ability of Optical Enhancement System in Early Gastric Cancer Demarcation.
abstract: This study aimed to evaluate the utility of optical enhancement (OE) in early gastric cancer demarcation. Twenty lesions of early gastric cancer were examined by PENTAX endoscopy system with OE-1 and OE-2 functions. The areas of tumor demarcation identified by 12 evaluators (6 novice and 6 experienced) were compared to the corresponding correct areas determined by postoperative histopathology findings. The misdiagnosed scores that were the sums of false-positive and false-negative areas were compared. Color of one hundred pixels from the inside of the cancerous area and the outside of the cancerous area was expressed as three-dimensional RGB component vectors. The mean vectors and covariance matrixes were calculated and the Mahalanobis distance, indicative of color differences between two areas, was tested. Comparisons of the misdiagnosed score revealed that OE-1 was preferred over WL-1 for gastric cancer demarcation for all 12 evaluators (p= 0.008) and in novice evaluators (p= 0.026). OE-2 was not significantly different from WL-2 in all cases. OE-1 images gave significantly larger Mahalanobis distances, indicative of color differences, than WL-1 images (p= 0.002). It was demonstrated that the OE Mode 1 has a significant advantage over the white light mode in demarcation of early gastric cancer.
authors: Department of Gastroenterology & Hepatology, Yamaguchi University Graduate School of Medicine, Ube, Japan.
authors: Misato
authors: M
authors: Nagao
authors: Department of Laboratory Science, Yamaguchi University Graduate School of Medicine, Ube, Japan.
authors: Jun
authors: 0000-0002-6695-9754
authors: J
authors: Nishikawa
authors: Department of Gastroenterology & Hepatology, Yamaguchi University Graduate School of Medicine, Ube, Japan.
authors: Ryo
authors: R
authors: Ogawa
authors: Department of Gastroenterology & Hepatology, Yamaguchi University Graduate School of Medicine, Ube, Japan.
authors: Sho
authors: S
authors: Sasaki
authors: Department of Gastroenterology & Hepatology, Yamaguchi University Graduate School of Medicine, Ube, Japan.
authors: Munetaka
authors: M
authors: Nakamura
authors: Department of Gastroenterology & Hepatology, Yamaguchi University Graduate School of Medicine, Ube, Japan.
authors: Junichi
authors: J
authors: Nishimura
authors: Department of Gastroenterology & Hepatology, Yamaguchi University Graduate School of Medicine, Ube, Japan.
authors: Atsushi
authors: A
authors: Goto
authors: Department of Gastroenterology & Hepatology, Yamaguchi University Graduate School of Medicine, Ube, Japan.
authors: Shinichi
authors: S
authors: Hashimoto
authors: Department of Gastroenterology & Hepatology, Yamaguchi University Graduate School of Medicine, Ube, Japan.
authors: Takeshi
authors: T
authors: Okamoto
authors: Department of Biomolecular Engineering Applied Molecular Bioscience, Yamaguchi University Graduate School of Medicine, Ube, Japan.
authors: Masato
authors: M
authors: Suenaga
authors: Department of Biomolecular Engineering Applied Molecular Bioscience, Yamaguchi University Graduate School of Medicine, Ube, Japan.
authors: Yoshihiko
authors: 0000-0003-4826-3507
authors: Y
authors: Hamamoto
authors: Department of Gastroenterology & Hepatology, Yamaguchi University Graduate School of Medicine, Ube, Japan.
authors: Isao
authors: 0000-0002-8365-7547
authors: I
authors: Sakaida