title: Final oocyte maturation with two different GnRH agonists in antagonist co-treated cycles at risk of ovarian hyperstimulation syndrome.
abstract: Triptorelin 0.2 mg and leuprolide 1 mg subcutaneous injections for triggering final follicular maturation were compared in patients with a high risk for ovarian hyperstimulation syndrome (OHSS). Infertile patients treated with GnRH antagonist protocol between January 2014 and March 2016 were recruited. Patients with high serum oestradiol levels on HCG day (>3000 pg/ml) indicating a risk of OHSS consisted of the study groups (A and B). Patients with serum oestradiol levels less than 3000 pg/ml consisted of the control group (C). A single injection of 0.2 mg triptorelin, 1 mg leuprolide and 10000 IU HCG were administered for final oocyte triggering in groups A (n = 63), B (n = 74) and C (n = 131), respectively. Demographic parameters were comparable between the groups. No cases of severe or moderate OHSS occurred in any group. The clinical pregnancy rates were 31.7%, 37.8% and 32.8% in groups A, B and C, respectively. Both injections had comparable efficacy in clinical outcome and OHSS risk. Regardless of preferred drug, GnRH agonist trigger for final oocyte maturation seems to be safe for patients with high OHSS risk, and can be safely used in fresh embryo transfer cycles.
authors: Department of Obstetrics and Gynecology, Ankara University School of Medicine, Kadın Hastalıkları ve Doğum AD, 06100 Cebeci, Ankara, Turkey.
authors: Yavuz Emre
authors: YE
authors: Şükür
authors: Department of Obstetrics and Gynecology, Ankara University School of Medicine, Kadın Hastalıkları ve Doğum AD, 06100 Cebeci, Ankara, Turkey. Electronic address: batuhanozmen@gmail.com.
authors: Batuhan
authors: B
authors: Özmen
authors: Department of Obstetrics and Gynecology, Ankara University School of Medicine, Kadın Hastalıkları ve Doğum AD, 06100 Cebeci, Ankara, Turkey.
authors: Elif Didem
authors: ED
authors: Özdemir
authors: Department of Obstetrics and Gynecology, Ankara University School of Medicine, Kadın Hastalıkları ve Doğum AD, 06100 Cebeci, Ankara, Turkey.
authors: Mehmet Murat
authors: MM
authors: Seval
authors: Department of Obstetrics and Gynecology, Ankara University School of Medicine, Kadın Hastalıkları ve Doğum AD, 06100 Cebeci, Ankara, Turkey.
authors: Erkan
authors: E
authors: Kalafat
authors: Department of Obstetrics and Gynecology, Ankara University School of Medicine, Kadın Hastalıkları ve Doğum AD, 06100 Cebeci, Ankara, Turkey.
authors: Murat
authors: M
authors: Sönmezer
authors: Department of Obstetrics and Gynecology, Ankara University School of Medicine, Kadın Hastalıkları ve Doğum AD, 06100 Cebeci, Ankara, Turkey.
authors: Bülent
authors: B
authors: Berker
authors: Department of Obstetrics and Gynecology, Ankara University School of Medicine, Kadın Hastalıkları ve Doğum AD, 06100 Cebeci, Ankara, Turkey.
authors: Ruşen
authors: R
authors: Aytaç
authors: Department of Obstetrics and Gynecology, Ankara University School of Medicine, Kadın Hastalıkları ve Doğum AD, 06100 Cebeci, Ankara, Turkey.
authors: Cem Somer
authors: CS
authors: Atabekoğlu
mesh_terms: D000293:Adolescent; D000328:Adult; D004958:Estradiol / Q000097:blood; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists* / Q000037:antagonists & inhibitors*; D006727:Hormone Antagonists / Q000627:therapeutic use; D006801:Humans; D007247:Infertility, Female / Q000628:therapy; D007248:Infertility, Male / Q000628:therapy; D016729:Leuprolide / Q000008:administration & dosage; D008297:Male; D009865:Oocytes / Q000166:cytology* / Q000187:drug effects; D009866:Oogenesis; D016471:Ovarian Hyperstimulation Syndrome / Q000188:drug therapy*; D010062:Ovulation Induction; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies; D012306:Risk; D020554:Sperm Injections, Intracytoplasmic; D017329:Triptorelin Pamoate / Q000008:administration & dosage; D055815:Young Adult
chemical_list: D006727:Hormone Antagonists; D017329:Triptorelin Pamoate; D007987:Gonadotropin-Releasing Hormone; D004958:Estradiol; D016729:Leuprolide
keywords: GnRH agonist trigger; GnRH antagonist; intracytoplasmic sperm injection; leuprolide; triptorelin