title: Macrophage migration inhibitory factor: a potential driver and biomarker for head and neck squamous cell carcinoma.
abstract: Macrophage migration inhibitory factor (MIF), a pleiotropic proinflammatory cytokine, has been showed to be associated with the immunopathogenesis of many diseases. Recent study demonstrated that MIF promoted tumorigenesis and tumor progression and played a critical role in various kinds of human cancer including head and neck squamous cell carcinoma(HNSCC). Hence, in this paper we retrospected the relationship between MIF and angiogenesis, epithelial-mesenchymal transition (EMT), inflammation, immune response, hypoxia microenvironment, and discussed whether it is a promising biomarker for diagnosis and supervisor of HNSCC.
authors: State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu Sichuan, People's Republic of China.|Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu Sichuan, People's Republic of China.
authors: Sha-Sha
authors: SS
authors: Wang
authors: State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu Sichuan, People's Republic of China.|Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu Sichuan, People's Republic of China.
authors: Xiao
authors: X
authors: Cen
authors: State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu Sichuan, People's Republic of China.|Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu Sichuan, People's Republic of China.
authors: Xin-Hua
authors: XH
authors: Liang
authors: State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu Sichuan, People's Republic of China.|Department of Oral Pathology, West China Hospital of Stomatology, Sichuan University, Chengdu Sichuan, People's Republic of China.
authors: Ya-Ling
authors: YL
authors: Tang
mesh_terms: D000818:Animals; D017209:Apoptosis; D001343:Autophagy; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D049109:Cell Proliferation; D058750:Epithelial-Mesenchymal Transition; D006258:Head and Neck Neoplasms / Q000235:genetics / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism; D019746:Intramolecular Oxidoreductases / Q000235:genetics / Q000378:metabolism*; D008263:Macrophage Migration-Inhibitory Factors / Q000235:genetics / Q000378:metabolism*; D009389:Neovascularization, Pathologic; D015398:Signal Transduction; D000077195:Squamous Cell Carcinoma of Head and Neck; D000072258:Tumor Hypoxia; D059016:Tumor Microenvironment
chemical_list: D014408:Biomarkers, Tumor; D018836:Inflammation Mediators; D008263:Macrophage Migration-Inhibitory Factors; D019746:Intramolecular Oxidoreductases; C515598:MIF protein, human
keywords: biomarker; head and neck squamous cell carcinoma; macrophage migration inhibitory factor; metastasis; tumorigenesis