title: Nanogold-Gallate Chitosan-Targeted Pulmonary Delivery for Treatment of Lung Cancer.
abstract: Lung cancer is one of the most of cancer type founds and a leading cause of death worldwide. Through the development of new candidate compound (3,4,5-tribenzyloxybenzoic acid (GAOBn)) and a drug delivery system of our design of quaternized chitosan-gallic acid-folic acid stabilized gold nanoparticles (Au@QCS-GA-FA) as the targeted nanocarrier for treatment of lung cancer, we have found that GAOBn not only showed high cytotoxicity against lung cancer cells (CHAGO) with more than tenfold than cisplatin, but also showed low toxicity against normal cells (CRL-1947). The combination Au@QCS-GA-FA/GAOBn showed highly efficient cellular uptake and localization of gold nanoparticles via the active targeting of cancer cells. This established the potential of Au@QCS-GA-FA as a nanocarrier for anticancer agent-targeted delivery for treatment of lung cancer.
authors: Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand.
authors: Seamkwan
authors: S
authors: Komenek
authors: Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand.
authors: Urarika
authors: U
authors: Luesakul
authors: Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand.
authors: Sanong
authors: S
authors: Ekgasit
authors: Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand.
authors: Tirayut
authors: T
authors: Vilaivan
authors: Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand.
authors: Narong
authors: N
authors: Praphairaksit
authors: Antibody Production Research Unit, Institute of Biotechnology and Genetic Engineering, Chulalongkorn University, Bangkok, 10330, Thailand.
authors: Songchan
authors: S
authors: Puthong
authors: Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand. nongnuj.j@chula.ac.th.
authors: Nongnuj
authors: N
authors: Muangsin
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics; D001672:Biocompatible Materials / Q000737:chemistry / Q000494:pharmacology; D048271:Chitosan / Q000737:chemistry / Q000494:pharmacology; D002945:Cisplatin / Q000008:administration & dosage / Q000493:pharmacokinetics; D016503:Drug Delivery Systems; D005079:Excipients / Q000494:pharmacology; D005492:Folic Acid / Q000494:pharmacology*; D005707:Gallic Acid / Q000494:pharmacology*; D006046:Gold / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy*; D053768:Metal Nanoparticles
chemical_list: D000970:Antineoplastic Agents; D001672:Biocompatible Materials; D005079:Excipients; D005707:Gallic Acid; D006046:Gold; D048271:Chitosan; D005492:Folic Acid; D002945:Cisplatin
keywords: drug delivery system; lung cancer; natural products; quaternized chitosan; targeted gold nanoparticles