title: Endogenous neurogenesis in adult mammals after spinal cord injury.
abstract: During the whole life cycle of mammals, new neurons are constantly regenerated in the subgranular zone of the dentate gyrus and in the subventricular zone of the lateral ventricles. Thanks to emerging methodologies, great progress has been made in the characterization of spinal cord endogenous neural stem cells (ependymal cells) and identification of their role in adult spinal cord development. As recently evidenced, both the intrinsic and extrinsic molecular mechanisms of ependymal cells control the sequential steps of the adult spinal cord neurogenesis. This review introduces the concept of adult endogenous neurogenesis, the reaction of ependymal cells after adult spinal cord injury (SCI), the heterogeneity and markers of ependymal cells, the factors that regulate ependymal cells, and the niches that impact the activation or differentiation of ependymal cells.
authors: Department of Neurobiology, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China.
authors: Hongmei
authors: H
authors: Duan
authors: School of Rehabilitation Medinice, China Rehabilitation Research Centre, Capital Medical University, Beijing, 100069, China.
authors: Wei
authors: W
authors: Song
authors: Department of Neurobiology, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China.
authors: Wen
authors: W
authors: Zhao
authors: Department of Neurobiology, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China.
authors: Yudan
authors: Y
authors: Gao
authors: Department of Neurobiology, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China. wack_lily@163.com.
authors: Zhaoyang
authors: Z
authors: Yang
authors: Department of Neurobiology, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China. lxgchina@sina.com.
authors: Xiaoguang
authors: X
authors: Li
mesh_terms: D000328:Adult; D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D049109:Cell Proliferation / Q000502:physiology; D006801:Humans; D058953:Neural Stem Cells / Q000502:physiology; D055495:Neurogenesis; D009474:Neurons / Q000502:physiology*; D013116:Spinal Cord / Q000503:physiopathology*; D013119:Spinal Cord Injuries / Q000503:physiopathology*
keywords: adult endogenous neurogenesis; adult mammals; ependymal cells; neural stem cells; regeneration; spinal cord injury