title: Release kinetics of high-sensitivity cardiac troponins I and T and troponin T upstream open reading frame peptide (TnTuORF) in clinically induced acute myocardial infarction.
abstract: BACKGROUND
  Troponin T upstream open reading frame peptide (TnTuORF) may be useful as a novel biomarker in acute cardiac syndromes.
  
  
  OBJECTIVE
  The study examined the early release kinetics of TnTuORF.
  
  
  METHODS
  We analyzed the time course of the release of cardiac troponins I and T and TnTuORF in patients (n = 31) with hypertrophic obstructive cardiomyopathy undergoing transcoronary ablation of septal hypertrophy (TASH).
  
  
  RESULTS
  Fifteen minutes after TASH, the levels of both troponins increased significantly (cTnT median: 18 ng/L versus 27 ng/L; cTnI median: 15 ng/L versus 25 ng/L). TnTuORF showed no variation.
  
  
  CONCLUSIONS
  We observed a significantly greater increase in cTnI compared with cTnT.
  
  
  CONCLUSIONS
  Our results demonstrate that troponin assays allow early detection of myocardial injury, whereas TnTuORF levels remain unchanged in this setting.
authors: a Department of Cardiology , Kerckhoff Heart and Thorax Center , Bad Nauheim , Germany.|b DZHK (German Center for Cardiovascular Research), partner site RheinMain , Frankfurt am Main , Germany.
authors: Christoph
authors: C
authors: Liebetrau
authors: a Department of Cardiology , Kerckhoff Heart and Thorax Center , Bad Nauheim , Germany.|b DZHK (German Center for Cardiovascular Research), partner site RheinMain , Frankfurt am Main , Germany.
authors: Luise
authors: L
authors: Gaede
authors: a Department of Cardiology , Kerckhoff Heart and Thorax Center , Bad Nauheim , Germany.|b DZHK (German Center for Cardiovascular Research), partner site RheinMain , Frankfurt am Main , Germany.
authors: J Sebastian
authors: JS
authors: Wolter
authors: a Department of Cardiology , Kerckhoff Heart and Thorax Center , Bad Nauheim , Germany.|b DZHK (German Center for Cardiovascular Research), partner site RheinMain , Frankfurt am Main , Germany.
authors: Julia
authors: J
authors: Homann
authors: c Department of Cardiac Surgery , Kerckhoff Heart and Thorax Center , Bad Nauheim , Germany.
authors: Alexander
authors: A
authors: Meyer
authors: d Medical Clinic I, Cardiology and Angiology , University of Giessen , Giessen , Germany.
authors: Oliver
authors: O
authors: Dörr
authors: a Department of Cardiology , Kerckhoff Heart and Thorax Center , Bad Nauheim , Germany.|b DZHK (German Center for Cardiovascular Research), partner site RheinMain , Frankfurt am Main , Germany.|c Department of Cardiac Surgery , Kerckhoff Heart and Thorax Center , Bad Nauheim , Germany.
authors: Holger M
authors: HM
authors: Nef
authors: a Department of Cardiology , Kerckhoff Heart and Thorax Center , Bad Nauheim , Germany.|b DZHK (German Center for Cardiovascular Research), partner site RheinMain , Frankfurt am Main , Germany.
authors: Christian
authors: C
authors: Troidl
authors: a Department of Cardiology , Kerckhoff Heart and Thorax Center , Bad Nauheim , Germany.|b DZHK (German Center for Cardiovascular Research), partner site RheinMain , Frankfurt am Main , Germany.|c Department of Cardiac Surgery , Kerckhoff Heart and Thorax Center , Bad Nauheim , Germany.
authors: Christian W
authors: CW
authors: Hamm
authors: a Department of Cardiology , Kerckhoff Heart and Thorax Center , Bad Nauheim , Germany.
authors: Helge
authors: H
authors: Möllmann
authors: e Department of Medicine , Christchurch Heart Institute, University of Otago , Christchurch , New Zealand.|f Cardiovascular Research Institute , National University of Singapore , Singapore.
authors: A Mark
authors: AM
authors: Richards
authors: e Department of Medicine , Christchurch Heart Institute, University of Otago , Christchurch , New Zealand.
authors: Chris J
authors: CJ
authors: Pemberton
mesh_terms: D015415:Biomarkers / Q000097:blood; D002312:Cardiomyopathy, Hypertrophic / Q000097:blood* / Q000175:diagnosis / Q000601:surgery; D017115:Catheter Ablation; D005260:Female; D006346:Heart Septum / Q000473:pathology / Q000601:surgery; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000175:diagnosis / Q000628:therapy; D010455:Peptides / Q000097:blood*; D019210:Troponin I / Q000097:blood / Q000378:metabolism*; D020107:Troponin T / Q000097:blood / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D010455:Peptides; C000617883:TnTuORF peptide, human; D019210:Troponin I; D020107:Troponin T
keywords: Acute coronary syndrome; HOCM; TASH