title: Current management of severe dengue infection.
abstract: Traditionally a disease mainly affecting the pediatric population, dengue burden has increased significantly in recent decades and adults with severe disease may become more common. There is currently no effective anti-viral agent available for the treatment of dengue and supportive care is the mainstay of management. Areas covered: We present a review of current literature on dengue severity classification systems and the management of severe dengue in adults. In particular, emphasis was placed on organ impairment in dengue and management of elderly individuals with multiple medical problems. Expert commentary: There is an urgent need to search for an effective anti-viral agent to treat infected individuals. The commercial availability of a dengue vaccine in older children has provided optimism in reducing the disease burden but long term efficacy and safety are unknown. The results from phase III trials of two new candidate vaccines are eagerly awaited.
authors: a Communicable Disease Centre, Institute of Infectious Diseases and Epidemiology , Tan Tock Seng Hospital , Singapore , Singapore.
authors: Tau Hong
authors: TH
authors: Lee
authors: a Communicable Disease Centre, Institute of Infectious Diseases and Epidemiology , Tan Tock Seng Hospital , Singapore , Singapore.
authors: Linda Kay
authors: LK
authors: Lee
authors: a Communicable Disease Centre, Institute of Infectious Diseases and Epidemiology , Tan Tock Seng Hospital , Singapore , Singapore.|b Yong Loo Lin School of Medicine , National University of Singapore , Singapore , Singapore.|c Lee Kong Chian School of Medicine , Nanyang Technological University , Singapore , Singapore.
authors: David Chien
authors: DC
authors: Lye
authors: a Communicable Disease Centre, Institute of Infectious Diseases and Epidemiology , Tan Tock Seng Hospital , Singapore , Singapore.|b Yong Loo Lin School of Medicine , National University of Singapore , Singapore , Singapore.|c Lee Kong Chian School of Medicine , Nanyang Technological University , Singapore , Singapore.|d Saw Swee Hock School of Public Health , National University of Singapore , Singapore , Singapore.
authors: Yee Sin
authors: YS
authors: Leo
mesh_terms: D000328:Adult; D000368:Aged; D000998:Antiviral Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D002199:Capillary Permeability / Q000187:drug effects; D002986:Clinical Trials as Topic; D053059:Dengue Vaccines / Q000008:administration & dosage*; D003716:Dengue Virus / Q000187:drug effects / Q000276:immunology / Q000302:isolation & purification*; D005440:Fluid Therapy; D006470:Hemorrhage / Q000209:etiology / Q000517:prevention & control; D006801:Humans; D010949:Plasma / Q000378:metabolism; D019595:Severe Dengue / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D012720:Severity of Illness Index
chemical_list: D000998:Antiviral Agents; D053059:Dengue Vaccines
keywords: Severe dengue; dengue shock syndrome; diagnosis; elderly; therapy