title: Unfavorable Donor Pretransplant APACHE II, SAPS II, and SOFA Scores Are Not Associated With Outcome: Implications for Heart Transplant Donor Selection.
abstract: BACKGROUND
  The quality of the donor heart and the individual risk of the recipient awaiting heart transplantation are difficult to assess. We investigated whether routinely used intensive care scoring systems can provide additional prognostic information on outcomes after heart transplantation.
  
  
  METHODS
  A total of 114 consecutive patients who underwent heart transplantation were included. The Acute Physiology and Chronic Health Evaluation II (APACHE II), the Simplified Acute Physiology Score (SAPS II), and the Sequential Organ Failure Assessment (SOFA) scores were calculated for donors and recipients. Risk factors such as the donor's cause of death, donor's catecholamine use, dialysis status of the recipient, and smoking pattern of the donor and the recipient were assessed. The association of these parameters with mortality, length of stay on the intensive care unit, and need for invasive ventilation was investigated.
  
  
  RESULTS
  The median APACHE II score of the donors was 20 (confidence interval [CI], 19-20), the median SAPS II score was 46 (CI, 45-48), and the median SOFA score was 10 (CI, 9-10). In contrast, the median scores of the recipients were as follows: APACHE II, 7 (CI, 6-8); SAPS II, 13 (CI, 12-14); and SOFA, 1 (CI, 1-2). None of the scores as calculated significantly predicted clinical outcome after transplantation.
  
  
  CONCLUSIONS
  This study detected no prognostic impact of donor-related risk factors on outcome after heart transplantation. Our findings support the growing practice of also considering organs from donors with high-risk scores for heart transplantation.
authors: University Heart Center, Cardiology, University Hospital Zurich, Zurich, Switzerland.
authors: G
authors: G
authors: Rizzi
authors: University Heart Center, Cardiology, University Hospital Zurich, Zurich, Switzerland.
authors: X
authors: X
authors: Startseva
authors: University Heart Center, Cardiology, University Hospital Zurich, Zurich, Switzerland.
authors: M
authors: M
authors: Wolfrum
authors: University Heart Center, Cardiology, University Hospital Zurich, Zurich, Switzerland.
authors: T F
authors: TF
authors: Lüscher
authors: University Heart Center, Cardiology, University Hospital Zurich, Zurich, Switzerland.
authors: F
authors: F
authors: Ruschitzka
authors: University Heart Center, Cardiology, University Hospital Zurich, Zurich, Switzerland.
authors: G M
authors: GM
authors: Fröhlich
authors: University Heart Center, Cardiology, University Hospital Zurich, Zurich, Switzerland. Electronic address: frank.enseleit@usz.ch.
authors: F
authors: F
authors: Enseleit
mesh_terms: D018806:APACHE; D000328:Adult; D000368:Aged; D046148:Donor Selection / Q000379:methods*; D005260:Female; D016027:Heart Transplantation / Q000379:methods / Q000706:statistics & numerical data*; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D063305:Organ Dysfunction Scores; D011379:Prognosis; D012307:Risk Factors; D012720:Severity of Illness Index; D000072878:Simplified Acute Physiology Score; D014019:Tissue Donors / Q000706:statistics & numerical data*; D016896:Treatment Outcome