title: Ratio of C-Reactive Protein to Albumin Predicts Muscle Mass in Adult Patients Undergoing Hemodialysis.
abstract: Recent studies have indicated that the ratio of C-reactive protein to albumin (CRP-Alb ratio) is associated with clinical outcomes in patients with disease. We examined the predictive value of this ratio in patients undergoing hemodialysis (HD). In this cross-sectional study, 91 eligible adult HD patients were analyzed, and the correlation between the CRP-Alb ratio and skeletal muscle mass normalized for body weight (SMM/wt; estimated using a bioelectrical impedance analyzer) was investigated. The mean age of the study participants was 54.9 ± 6.6 years (ranging from 27 to 64 years); 43 (47.2%) were men. The mean values for the SMM/wt were 39.1% ± 5.4%. The CRP-Alb ratio was found to be negatively correlated with SMM/wt (r = -0.33, P = 0.002) and creatinine (r = -0.20, P = 0.056). All the univariate significant and nonsignificant relevant covariates were selected for multivariable stepwise regression analysis. We determined that the homeostasis model assessment-estimated insulin resistance and CRP-Alb ratio were independent risk determinants for SMM/wt (βHOMA-IR = -0.18 and βCRP-Alb ratio = -3.84, adjusted R2 = 0.32). This study indicated that the CRP-Alb ratio may help clinicians in predicting muscle mass in adult patients undergoing HD.
authors: School of Nutrition and Health Sciences, Taipei Medical University, Taipei, Taiwan, Republic of China.
authors: Te-Chih
authors: TC
authors: Wong
authors: Department of Dietetics, Taipei Medical University Hospital, Taipei, Taiwan, Republic of China.
authors: Hsiu-Yueh
authors: HY
authors: Su
authors: School of Nutrition and Health Sciences, Taipei Medical University, Taipei, Taiwan, Republic of China.
authors: Yu-Tong
authors: YT
authors: Chen
authors: School of Nutrition and Health Sciences, Taipei Medical University, Taipei, Taiwan, Republic of China.
authors: Pei-Yu
authors: PY
authors: Wu
authors: Division of Nephrology, Department of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan, Republic of China.
authors: Hsi-Hsien
authors: HH
authors: Chen
authors: Division of Nephrology, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan, Republic of China.
authors: Tso-Hsiao
authors: TH
authors: Chen
authors: Division of Nephrology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan, Republic of China.
authors: Yung-Ho
authors: YH
authors: Hsu
authors: School of Nutrition and Health Sciences, Taipei Medical University, Taipei, Taiwan, Republic of China.|Nutrition Research Center, Taipei Medical University Hospital, Taipei, Taiwan, Republic of China.
authors: Shwu-Huey
authors: http://orcid.org/0000-0002-3707-1166
authors: SH
authors: Yang
mesh_terms: D000418:Albumins / Q000378:metabolism*; D002097:C-Reactive Protein / Q000378:metabolism*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000473:pathology*; D009135:Muscular Diseases / Q000473:pathology; D009929:Organ Size; D006435:Renal Dialysis
chemical_list: D000418:Albumins; D002097:C-Reactive Protein