title: Anti-metastatic Effect of Short-term Postoperative Anticoagulation for Patients Undergoing Curative Resection of Colorectal Cancer.
abstract: The purpose of this study was to examine the efficacy of anticoagulant fondaparinux postoperatively for preventing recurrence after curative resection of colorectal cancer with lymphnode metastasis.
  
  
  
  The records of 279 patients who underwent curative resection of colorectal cancer with lymph-node metastasis between 2006 and 2013 were reviewed. Patients were divided into two groups based on the type of prophylaxis for postoperative venous thromboembolism: the FPX group, treated with subcutaneous fondaparinux plus intermittent pneumatic compression; and the IPC group, treated with intermittent pneumatic compression alone. Recurrence-free survival was compared using propensity score matching.
  
  
  
  In the propensity score-matched cohort, the 3-year recurrence-free survival rate was 74.9% and 74.4% in the FPX (n=61) and IPC groups (n=61), respectively (p=0.830).
  
  
  
  Our results do not suggest that short-term postoperative anticoagulation as prophylaxis for venous thromboembolism prevents colorectal cancer recurrence after curative resection.
authors: Department of Surgery, National Hospital Organization, Osaka National Hospital, Osaka, Japan.
authors: Yusuke
authors: Y
authors: Yamaoka
authors: Department of Surgery, National Hospital Organization, Osaka National Hospital, Osaka, Japan mikeda@onh.go.jp.
authors: Masataka
authors: M
authors: Ikeda
authors: Department of Surgery, Higashiosaka City General Hospital, Higashiosaka, Osaka, Japan.
authors: Masakazu
authors: M
authors: Ikenaga
authors: Department of Surgery, National Hospital Organization, Osaka National Hospital, Osaka, Japan.
authors: Hirotomo
authors: H
authors: Murakami
authors: Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita, Japan.
authors: Naotsugu
authors: N
authors: Haraguchi
authors: Department of Surgery, National Hospital Organization, Osaka National Hospital, Osaka, Japan.
authors: Masakazu
authors: M
authors: Miyake
authors: Department of Gastroenterological Surgery, NTT West Osaka Hospital, Osaka, Japan.
authors: Kazuyoshi
authors: K
authors: Yamamoto
authors: Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita, Japan.
authors: Tadafumi
authors: T
authors: Asaoka
authors: Department of Surgery, National Hospital Organization, Osaka National Hospital, Osaka, Japan.
authors: Kazuhiro
authors: K
authors: Nishikawa
authors: Department of Surgery, National Hospital Organization, Osaka National Hospital, Osaka, Japan.
authors: Atsushi
authors: A
authors: Miyamoto
authors: Department of Surgery, National Hospital Organization, Osaka National Hospital, Osaka, Japan.
authors: Michihiko
authors: M
authors: Miyazaki
authors: Department of Surgery, National Hospital Organization, Osaka National Hospital, Osaka, Japan.
authors: Motohiro
authors: M
authors: Hirao
authors: Department of Surgery, National Hospital Organization, Osaka National Hospital, Osaka, Japan.
authors: Shoji
authors: S
authors: Nakamori
authors: Department of Surgery, National Hospital Organization, Osaka National Hospital, Osaka, Japan.
authors: Mitsugu
authors: M
authors: Sekimoto
mesh_terms: D000368:Aged; D000925:Anticoagulants / Q000008:administration & dosage*; D015179:Colorectal Neoplasms / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D009362:Neoplasm Metastasis; D011182:Postoperative Care
chemical_list: D000925:Anticoagulants
keywords: Colorectal cancer; anticancer effect; anticoagulation; fondaparinux; propensity score matching; recurrence