title: Lectin Receptors Expressed on Myeloid Cells.
abstract: Lectins recognize a diverse array of carbohydrate structures and perform numerous essential biological functions. Here we focus on only two families of lectins, the Siglecs and C-type lectins. Triggering of intracellular signaling cascades following ligand recognition by these receptors can have profound effects on the induction and modulation of immunity. In this chapter, we provide a brief overview of each family and then focus on selected examples that highlight how these lectins can influence myeloid cell functioning in health and disease. Receptors that are discussed include Sn (Siglec-1), CD33 (Siglec-3), and Siglec-5, -7, -8, -9, -10, -11, -14, -15, -E, -F, and -G as well as Dectin-1, MICL, Dectin-2, Mincle/MCL, and the macrophage mannose receptor.
authors: MRC Centre for Medical Mycology, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, United Kingdom.
authors: Gordon D
authors: GD
authors: Brown
authors: Division of Cell Signalling and Immunology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom.
authors: Paul R
authors: PR
authors: Crocker
mesh_terms: D000818:Animals; D006801:Humans; D022423:Myeloid Cells / Q000276:immunology / Q000378:metabolism*; D011975:Receptors, Mitogen / Q000096:biosynthesis* / Q000276:immunology
chemical_list: D011975:Receptors, Mitogen