title: Purinergic signaling during Porphyromonas gingivalis infection.
abstract: Despite recent advances unraveling mechanisms of host-pathogen interactions in innate immunity, the participation of purinergic signaling in infection-driven inflammation remains an emerging research field with many unanswered questions. As one of the most-studied oral pathogens, Porphyromonas gingivalis is considered as a keystone pathogen with a central role in development of periodontal disease. This pathogen needs to evade immune-mediated defense mechanisms and tolerate inflammation in order to survive in the host. In this review, we summarize evidence showing that purinergic signaling modulates P. gingivalis survival and cellular immune responses, and discuss the role played by inflammasome activation and cell death during P. gingivalis infection.
authors: Immunobiology Program, Biophysics Institute of the Federal University of Rio de Janeiro, Brazil.
authors: Cássio Luiz Coutinho
authors: CLC
authors: Almeida-da-Silva
authors: Department of Oral Health Sciences, College of Dental Medicine, Medical University of South Carolina, Charleston, SC, USA; Department of Biomedical Sciences, University of the Pacific, San Francisco, USA.
authors: Ana Carolina
authors: AC
authors: Morandini
authors: Department of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, Brazil.
authors: Henning
authors: H
authors: Ulrich
authors: Immunobiology Program, Biophysics Institute of the Federal University of Rio de Janeiro, Brazil; Department of Biomedical Sciences, University of the Pacific, San Francisco, USA.
authors: David M
authors: DM
authors: Ojcius
authors: Immunobiology Program, Biophysics Institute of the Federal University of Rio de Janeiro, Brazil. Electronic address: rcsilva@biof.ufrj.br.
authors: Robson
authors: R
authors: Coutinho-Silva
mesh_terms: D006801:Humans; D007113:Immunity, Innate; D058847:Inflammasomes / Q000276:immunology*; D007249:Inflammation; D016966:Porphyromonas gingivalis / Q000276:immunology*; D015398:Signal Transduction
chemical_list: D058847:Inflammasomes
keywords: Inflammasome; Innate immunity; Oral microbes; P2X7 receptor; Porphyromonas gingivalis; Purinergic receptors