title: Synthetic biology for CO2fixation.
abstract: Recycling of carbon dioxide (CO2) into fuels and chemicals is a potential approach to reduce CO2emission and fossil-fuel consumption. Autotrophic microbes can utilize energy from light, hydrogen, or sulfur to assimilate atmospheric CO2into organic compounds at ambient temperature and pressure. This provides a feasible way for biological production of fuels and chemicals from CO2under normal conditions. Recently great progress has been made in this research area, and dozens of CO2-derived fuels and chemicals have been reported to be synthesized by autotrophic microbes. This is accompanied by investigations into natural CO2-fixation pathways and the rapid development of new technologies in synthetic biology. This review first summarizes the six natural CO2-fixation pathways reported to date, followed by an overview of recent progress in the design and engineering of CO2-fixation pathways as well as energy supply patterns using the concept and tools of synthetic biology. Finally, we will discuss future prospects in biological fixation of CO2.
authors: CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China.|University of the Chinese Academy of Sciences, Beijing, 100049, China.
authors: Fuyu
authors: F
authors: Gong
authors: CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China. caiz@im.ac.cn.
authors: Zhen
authors: Z
authors: Cai
authors: CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China. yli@im.ac.cn.
authors: Yin
authors: Y
authors: Li
mesh_terms: D001105:Archaea / Q000235:genetics / Q000378:metabolism; D001419:Bacteria / Q000235:genetics / Q000378:metabolism; D057486:Carbon Cycle; D002245:Carbon Dioxide / Q000378:metabolism*; D003247:Conservation of Natural Resources / Q000379:methods; D005579:Fossil Fuels; D007218:Industrial Microbiology / Q000379:methods; D060847:Metabolic Engineering / Q000379:methods; D010944:Plants / Q000235:genetics / Q000378:metabolism; D058615:Synthetic Biology / Q000379:methods*
chemical_list: D005579:Fossil Fuels; D002245:Carbon Dioxide
keywords: CO2-fixation pathway; carbon dioxide fixation; energy supply; synthetic biology