title: Radiofrequency in the Management of Colorectal Liver Metastases: A 10-Year Experience at a Single Center.
abstract: Liver resection is the curative treatment for patients with colorectal liver metastases (CRLMs), with five-year survival rates of 30-50%. Radiofrequency ablation (RFA) is a local and useful alternative for patients with non-resectable CRLMs to obtain complete tumor clearance. The aim of this study was to analyze survival rates with this local treatment.
  
  
  
  All patients who underwent RFA and resection or RFA alone for unresectable CRLMs between 2001 and 2012 were included in a retrospective study. Descriptive and survival statistics were calculated. Morbidity, mortality, and recurrence were also analyzed.
  
  
  
  The study involved 72 patients and 179 lesions. RFA was performed in 109 procedures. Mortality was 2.7% and morbidity was 25.7%. Local recurrence concerned 25.7% of lesions. Independent risk factors for recurrence were more than one CRLM (p= 0.0427) and size of largest CRLM greater than 3 cm (p= 0.0139). The five-year overall survival rate was 45.5% and the five-year disease-free survival (DFS) was 9.9%.
  
  
  
  This study shows RFA has good oncological outcomes. The combination of RFA and resection is considered as a curative treatment for patients with unresectable CRLMs.
authors: Service de chirurgie viscerale et digestive, Centre Hospitalier Universitaire d'Angers, Angers, France.
authors: Sandra
authors: S
authors: Aissou
authors: Service de radiologie interventionnelle, département d'imagerie médicale Centre Hospitalier Universitaire d'Angers, Angers, France.
authors: Victoire
authors: V
authors: Cartier
authors: Service de chirurgie viscérale et digestive, Centre Hospitalier Universitaire d'Angers, Angers, France, Faculté de médecine d'Angers, Angers, France.
authors: Antoine
authors: A
authors: Hamy
authors: Service de chirurgie viscérale et digestive, Centre Hospitalier Universitaire d'Angers, Angers, France.
authors: Fleur
authors: F
authors: Plumereau
authors: Service de radiologie interventionnelle, département d'imagerie médicale Centre Hospitalier Universitaire d'Angers, Angers, France.
authors: Christophe
authors: C
authors: Aube
authors: Service de chirurgie viscérale et digestive, Centre Hospitalier Universitaire d'Angers, Angers, France, Faculté de médecine d'Angers, Angers, France.
authors: Emilie
authors: E
authors: Lermite
mesh_terms: D017115:Catheter Ablation; D015179:Colorectal Neoplasms / Q000473:pathology*; D006498:Hepatectomy; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary* / Q000628:therapy*; D009364:Neoplasm Recurrence, Local; D012189:Retrospective Studies; D016896:Treatment Outcome