title: Effect of phentermine on weight reduction in a pediatric weight management clinic.
abstract: Phentermine is the most widely prescribed obesity medication in adults, yet studies of its use in the pediatric population are limited. We conducted a retrospective chart review of adolescents with obesity treated in a pediatric weight management clinic to examine the weight loss effectiveness of phentermine added to standard of care (SOC) lifestyle modification therapy versus SOC alone. All patients receiving phentermine plus SOC (n=25) were matched with a comparison group receiving only SOC (n=274). Differences at 1, 3 and 6 months were evaluated using generalized estimated equations adjusting for age, sex and baseline body mass index (BMI) and robust variance standard error estimates for confidence intervals and P-values. Phentermine use was associated with a greater percent change in BMI at 1 month (-1.6%; 95% confidence interval (CI): -2.6, -0.6%; P=0.001), 3 months (-2.9%; 95% CI: -4.5, -1.4%; P<0.001) and 6 months (-4.1%; 95% CI: -7.1, -1.0%; P=0.009) compared with SOC alone, with no differences in systolic or diastolic blood pressure between groups. Heart rate was higher at all time-points in the phentermine plus SOC compared with SOC-only group. These data suggest that short-term use of phentermine added to SOC may enhance weight loss in adolescents with obesity in the clinical setting.
authors: Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN, USA.
authors: J R
authors: JR
authors: Ryder
authors: Division of Biostatistics, University of Minnesota School of Public Health, Minneapolis, MN, USA.
authors: A
authors: A
authors: Kaizer
authors: Division of Biostatistics, University of Minnesota School of Public Health, Minneapolis, MN, USA.
authors: K D
authors: KD
authors: Rudser
authors: Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN, USA.
authors: A
authors: A
authors: Gross
authors: Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN, USA.|Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA.
authors: A S
authors: AS
authors: Kelly
authors: Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN, USA.
authors: C K
authors: CK
authors: Fox
mesh_terms: D000293:Adolescent; D019440:Anti-Obesity Agents / Q000627:therapeutic use*; D001521:Behavior Therapy; D004038:Diet, Reducing; D005260:Female; D006801:Humans; D008297:Male; D008910:Minnesota / Q000453:epidemiology; D063766:Pediatric Obesity / Q000517:prevention & control* / Q000628:therapy; D010645:Phentermine / Q000627:therapeutic use*; D012189:Retrospective Studies; D040242:Risk Reduction Behavior; D016896:Treatment Outcome; D015431:Weight Loss / Q000187:drug effects
chemical_list: D019440:Anti-Obesity Agents; D010645:Phentermine