title: Risk factors for high death and loss-to-follow-up rates among patients with multidrug-resistant tuberculosis at a programmatic management unit.
abstract: Among 186 retrospectively evaluated patients with multidrug-resistant tuberculosis, 33.9% were cured, 6.6% completed treatment, 25% died, 18.3% were lost to follow-up, 2.2% failed treatment, and 13.8% were still undergoing treatment by the end of the study period. Rural residence was a risk factor for loss to follow-up (odds ratio [OR], 3.315; P = .016), whereas baseline body weight <40 kg (OR, 2.175; P = .042) and resistance to ofloxacin (OR, 2.889; P = .025) were risk factors for death. Despite programmatic management, treatment outcomes of the current cohort were distressing.
authors: Department of Pulmonology, Postgraduate Medical Institute, Peshawar, Pakistan.
authors: Arshad
authors: A
authors: Javaid
authors: Department of Pulmonology, Nishtar Hospital Multan, Punjab, Pakistan. Electronic address: dzshaheen@hotmail.com.
authors: Zubair
authors: Z
authors: Shaheen
authors: Programmatic Management Unit for Drug-Resistant TB, Nishtar Hospital Multan, Punjab, Pakistan.
authors: Muhammad
authors: M
authors: Shafqat
authors: Discipline of Clinical Pharmacy, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Pulau Pinang, Malaysia.
authors: Amer Hayat
authors: AH
authors: Khan
authors: Discipline of Clinical Pharmacy, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Pulau Pinang, Malaysia; Faculty of Pharmacy, University of Balochistan, Quetta, Pakistan. Electronic address: nafeesuob@gmail.com.
authors: Nafees
authors: N
authors: Ahmad
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D005260:Female; D006801:Humans; D059012:Lost to Follow-Up; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D016019:Survival Analysis; D018088:Tuberculosis, Multidrug-Resistant / Q000401:mortality*; D055815:Young Adult
keywords: Ofloxacin; Pakistan; Rural residence