title: Change of cystatin C values in preterm infants with asphyxia-From two centers of China.
abstract: BACKGROUND
  To explore the values of cystatin C (Cys-C) in asphyxial preterm babies as an effective endogenous marker of renal function.
  
  
  METHODS
  After birth, preterm infants with 5-minute Apgar score <8 were included into the asphyxia group. Finally, 276 preterm infants born in two neonatal intensive care units were studied (including 78 babies in the asphyxia group and 198 babies in the control group). Blood samples were obtained from peripheral veins on day 1, day 7, and day 28 when routine blood screening tests were performed.
  
  
  RESULTS
  In first day samples, the mean levels of Cys-C were 2.21 (1.49-2.98) mg/L with gestational age (GA) >32, 1.94 (1.37-2.76) mg/L with GA 28-32, and 1.87 (1.49-2.13) mg/L with GA <28 in the asphyxia group. In seventh day samples, the mean levels of Cys-C were 2.35 (1.57-3.26) mg/L with GA>32, 2.07 (1.42-2.90) mg/L with GA 28-32, and 1.69 (1.13-2.04) mg/L with GA <28. In twenty-eighth day samples, the mean levels of Cys-C were 1.92 (1.61-2.13) mg/L with GA>32, 1.79 (1.29-1.84) mg/L with GA 28-32, and 1.66 (1.21-2.10) mg/L GA <28. There were significant differences not only between the asphyxia and control groups, but also between the mild, moderate, and severe asphyxia groups.
  
  
  CONCLUSIONS
  Cys-C has a good distinguishability in asphyxial neonates in spite of gestational age or birth weight in the Chinese population. Further studies with large numbers of cases are required to assess whether Cys-C could replace creatinine (Cr) and blood urea nitrogen (BUN) as an endogenous marker of renal function.
authors: Department of Neonates, Nanjing Children's Hospital, Nanjing Medical University, Nanjing, China.
authors: Yang
authors: Y
authors: Yang
authors: Department of Neonates, Nanjing Children's Hospital, Nanjing Medical University, Nanjing, China.
authors: Yue
authors: Y
authors: Wu
authors: Department of Pediatrics, The First Affiliated Hospital, Nanjing Medical University, Nanjing, China.
authors: Jing-Jing
authors: JJ
authors: Pan
authors: Department of Neonates, Nanjing Children's Hospital, Nanjing Medical University, Nanjing, China.
authors: Rui
authors: R
authors: Cheng
mesh_terms: D000328:Adult; D001238:Asphyxia Neonatorum / Q000097:blood / Q000453:epidemiology / Q000628:therapy; D001806:Blood Urea Nitrogen; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D003404:Creatinine / Q000097:blood; D055316:Cystatin C / Q000097:blood*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature / Q000097:blood; D015931:Intensive Care, Neonatal; D008297:Male
chemical_list: D055316:Cystatin C; D003404:Creatinine
keywords: asphyxia; blood urea nitrogen; creatinine; cystatin C