title: Expanding clinical laboratory tobacco product evaluation methods to loose-leaf tobacco vaporizers.
abstract: Novel tobacco products entering the US market include electronic cigarettes (ECIGs) and products advertised to "heat, not burn" tobacco. There is a growing literature regarding the acute effects of ECIGs. Less is known about "heat, not burn" products. This study's purpose was to expand existing clinical laboratory methods to examine, in cigarette smokers, the acute effects of a "heat, not burn" "loose-leaf tobacco vaporizer" (LLTV).
  
  
  
  Plasma nicotine and breath carbon monoxide (CO) concentration and tobacco abstinence symptom severity were measured before and after two 10-puff (30-s interpuff interval) product use bouts separated by 60min. LLTV effects were compared to participants' own brand (OB) cigarettes and an ECIG (3.3V; 1.5ohm; 18mg/ml nicotine).
  
  
  
  Relative to OB, LLTV increased plasma nicotine concentration to a lesser degree, did not increase CO, and did not appear to reduce abstinence symptoms as effectively. Relative to ECIG, LLTV nicotine and CO delivery and abstinence symptom suppression did not differ. Participants reported that both the LLTV and ECIG were significantly less satisfying than OB.
  
  
  
  Results demonstrate that LLTVs are capable of delivering nicotine and suppressing tobacco abstinence symptoms partially; acute effects of these products can be evaluated using existing clinical laboratory methods. Results can inform tobacco product regulation and may be predictive of the extent that these products have the potential to benefit or harm overall public health.
authors: Virginia Commonwealth University, Department of Psychology and Center for the Study of Tobacco Products, Box 980205, Richmond, VA 23298-0205, USA.
authors: Alexa A
authors: AA
authors: Lopez
authors: Virginia Commonwealth University, Department of Psychology and Center for the Study of Tobacco Products, Box 980205, Richmond, VA 23298-0205, USA.
authors: Marzena
authors: M
authors: Hiler
authors: Virginia Commonwealth University, Department of Psychology and Center for the Study of Tobacco Products, Box 980205, Richmond, VA 23298-0205, USA.
authors: Sarah
authors: S
authors: Maloney
authors: Virginia Commonwealth University, Department of Psychology and Center for the Study of Tobacco Products, Box 980205, Richmond, VA 23298-0205, USA.
authors: Thomas
authors: T
authors: Eissenberg
authors: Virginia Commonwealth University, Department of Psychology and Center for the Study of Tobacco Products, Box 980205, Richmond, VA 23298-0205, USA. Electronic address: abbrelan@vcu.edu.
authors: Alison B
authors: AB
authors: Breland
mesh_terms: D000293:Adolescent; D000328:Adult; D002248:Carbon Monoxide / Q000097:blood*; D066300:Electronic Nicotine Delivery Systems; D005260:Female; D006801:Humans; D007753:Laboratories; D008297:Male; D008875:Middle Aged; D009330:Nebulizers and Vaporizers; D009538:Nicotine / Q000097:blood*; D011634:Public Health; D012907:Smoking / Q000097:blood*; D013375:Substance Withdrawal Syndrome / Q000097:blood; D014029:Tobacco Use Disorder / Q000097:blood*; D000072137:Vaping / Q000097:blood*; D055815:Young Adult; D062789:Tobacco Products
chemical_list: D009538:Nicotine; D002248:Carbon Monoxide
keywords: Carbon monoxide; Electronic cigarette; Heat-not-burn products; Loose-leaf tobacco vaporizer; Plasma nicotine