title: Vascular effects of the lercanidipine/enalapril combination: clinical relevance.
abstract: Hypertension is associated with alterations in the vascular structure, which in turn enhance the risk of cardiovascular events. Notably, anti-hypertensive treatment may prevent or regress the changes of arterial wall structures. Lercanidipine is a third-generation CCB with peculiar pharmaceutical properties. Enalapril is an effective drug acting on the renin-angiotensin-aldosterone axis. This commentary discusses the vascular effects of the lercanidipine/enalapril combination, and comments on their potential clinical relevance.
authors: a Department of Medicine and Surgery, University of Milan-Bicocca , Milan , Italy.|b Department of Cardiovascular Neural and Metabolic Sciences, S.Luca Hospital, IRCCS Istituto Auxologico Italiano , Milan , Italy.
authors: Gianfranco
authors: G
authors: Parati
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D001808:Blood Vessels / Q000187:drug effects* / Q000473:pathology; D004095:Dihydropyridines / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D004656:Enalapril / Q000627:therapeutic use*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*
chemical_list: D000959:Antihypertensive Agents; D004095:Dihydropyridines; D004656:Enalapril; C060343:lercanidipine
keywords: Hypertension; Lercanidipine; Microcirculation; Stiffness; Vascular effects