title: Recent development of ATP-competitive small molecule phosphatidylinostitol-3-kinase inhibitors as anticancer agents.
abstract: Phosphatidylinostitol-3-kinase (PI3K) is the potential anticancer target in the PI3K/Akt/ mTOR pathway. Here we reviewed the ATP-competitive small molecule PI3K inhibitors in the past few years, including the pan Class I PI3K inhibitors, the isoform-specific PI3K inhibitors and/or the PI3K/mTOR dual inhibitors.
authors: School of Chemistry and Pharmaceutical Engineering, Qilu University of Technology, Jinan, P. R. China.|Department of Hematology, Qilu Hospital, Shandong University, Jinan, P. R. China.
authors: Yu
authors: Y
authors: Liu
authors: School of Chemistry and Pharmaceutical Engineering, Qilu University of Technology, Jinan, P. R. China.
authors: Wen-Zhu
authors: WZ
authors: Wan
authors: School of Chemistry and Pharmaceutical Engineering, Qilu University of Technology, Jinan, P. R. China.
authors: Yan
authors: Y
authors: Li
authors: School of Chemistry and Pharmaceutical Engineering, Qilu University of Technology, Jinan, P. R. China.
authors: Guan-Lian
authors: GL
authors: Zhou
authors: Department of Hematology, Qilu Hospital, Shandong University, Jinan, P. R. China.
authors: Xin-Guang
authors: XG
authors: Liu
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D055808:Drug Discovery; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000201:enzymology; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D000081082:Phosphoinositide-3 Kinase Inhibitors; D047428:Protein Kinase Inhibitors / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D015398:Signal Transduction; D054852:Small Molecule Libraries / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism
chemical_list: D000255:Adenosine Triphosphate; D000970:Antineoplastic Agents; D019869:Phosphatidylinositol 3-Kinases; D000081082:Phosphoinositide-3 Kinase Inhibitors; D047428:Protein Kinase Inhibitors; D054852:Small Molecule Libraries; D058570:TOR Serine-Threonine Kinases; C546842:MTOR protein, human
keywords: PI3K; anticancer; inhibitor; mTOR pathway; phosphatidylinostitol-3-kinase