title: Chemistry and Bioactivity of Briaranes from the South China Sea Gorgonian Dichotella gemmacea.
abstract: Seven new briarane diterpenoids, gemmacolides AZ-BF (1-7), were isolated together with eight known analogues (8-15) from the South China gorgonianDichotella gemmacea. Their structures were elucidated based on detailed spectroscopic analysis and a comparison with reported data. In an in vitro bioassay, these compounds exhibited different levels of growth inhibition activity against A549 and MG63 cells, giving continuous evidences about the biological contribution of functional groups at C-2, C-12, C-13, and C-16. These compounds were also evaluated for their antibacterial and antifungal activities. Compound8exhibited a potential antibacterial activity against both Gram-positive bacteriumBacillus megateriumand Gram-negative bacteriumEscherichia coli.
authors: Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guo-He Road, Shanghai 200433, China. licuiwan@163.com.
authors: Cui
authors: C
authors: Li
authors: Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guo-He Road, Shanghai 200433, China. lmp12@163.com.
authors: Ming-Ping
authors: MP
authors: La
authors: Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guo-He Road, Shanghai 200433, China. tanghua0309@126.com.
authors: Hua
authors: H
authors: Tang
authors: Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guo-He Road, Shanghai 200433, China. sunpeng78@126.com.
authors: Peng
authors: P
authors: Sun
authors: Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guo-He Road, Shanghai 200433, China. liubaoshu@126.com.
authors: Bao-Shu
authors: BS
authors: Liu
authors: Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guo-He Road, Shanghai 200433, China. zclnathan@163.com.
authors: Chun-Lin
authors: CL
authors: Zhuang
authors: Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guo-He Road, Shanghai 200433, China. yiyanghua@126.com.
authors: Yang-Hua
authors: YH
authors: Yi
authors: Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guo-He Road, Shanghai 200433, China. wenzhang1968@163.com.
authors: Wen
authors: W
authors: Zhang
mesh_terms: D000072283:A549 Cells; D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology; D001410:Bacillus megaterium / Q000187:drug effects; D045744:Cell Line, Tumor; D002681:China; D004224:Diterpenes / Q000737:chemistry* / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects; D006801:Humans
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D004224:Diterpenes
keywords: Dichotella gemmacea; biological activity; briarane diterpenoids; gorgonian; structure elucidation