title: Developing a paediatric drug formulary for the Netherlands.
abstract: As many drugs in paediatrics are used off-label, prescribers face a lack of evidence-based dosing guidelines. A Dutch framework was developed to provide dosing guidelines based on best available evidence from registration data, investigator-initiated research, professional guidelines, clinical experience and consensus. This has clarified the scientific grounds of drug use for children and encouraged uniformity in prescribing habits in the Netherlands. The developed framework and the current content of the Dutch Paediatric Formulary could be used as basis for similar initiatives worldwide, preferably in a concerted effort to ultimately provide children with effective and safe drug therapy.
authors: Department of Paediatrics, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands.
authors: Tjitske M
authors: TM
authors: van der Zanden
authors: Intensive Care and Paediatric Surgery, Erasmus MC Sophia Children's Hospital, Rotterdam, The Netherlands.|Department of Pharmacology and Toxicology, Radboud University, Nijmegen, The Netherlands.
authors: Saskia N
authors: SN
authors: de Wildt
authors: Department of Pharmacy, University Medical Center Utrecht-Wilhelmina Children's Hospital, Utrecht, The Netherlands.
authors: Yves
authors: Y
authors: Liem
authors: Child Health Evaluative Sciences (CHES), The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
authors: Martin
authors: M
authors: Offringa
authors: Intensive Care and Paediatric Surgery, Erasmus MC Sophia Children's Hospital, Rotterdam, The Netherlands.
authors: Matthijs
authors: M
authors: de Hoog
mesh_terms: D002648:Child; D032921:Consensus; D004334:Drug Administration Schedule; D017277:Drug Approval; D019317:Evidence-Based Medicine; D005569:Formularies as Topic; D006801:Humans; D051188:Knowledge Bases; D009426:Netherlands; D056687:Off-Label Use
keywords: Evidence Based Medicine; Pharmacology; Therapeutics