title: Intravenous thrombolysis with rt-PA in stroke: experience of the moroccan stroke unit.
abstract: The majority of strokes are due to blockage of an artery in the brain by a blood clot. Prompt treatment with thrombolytic drugs can restore blood flow before major brain damage has occurred. We report the case series of all patients who were treated with rt-PA at Stroke Unit of HASSAN II University hospital between 2010 and 2013. There were 52 patients treated with intravenous rtPA during the study period. The mean age was 63 years with the no gender predominance (sex ratio 1.02). Hypertension was the most common vascular risk factor (31%) and 17% of patients suffered from atrial fibrillation. 17 of 52 patients (32.7%) were treated within a 3 hours window of stroke onset and 35 of 52 (67.3%) patients were treated within 3-4.5 h. Twenty five patients (48%) had significant early improvements within 24 hours and twenty one (40.3%) patients had good outcomes at 3 months and fifteen patients (29%) died within the same period.
authors: Neurology Department, Hassan II University Hospital, Fez, Morocco.
authors: Naima
authors: N
authors: Chtaou
authors: Neurology Department, Hassan II University Hospital, Fez, Morocco.
authors: Lamyae
authors: L
authors: Rachdi
authors: Neurology Department, Hassan II University Hospital, Fez, Morocco; Laboratory of Epidemiology and Public Health, Faculty of Medicine and Pharmacy, Sidi Mohammed BenAbdellah university Fez, Morocco.
authors: Aouatef El
authors: AE
authors: Midaoui
authors: Neurology Department, Hassan II University Hospital, Fez, Morocco.
authors: Zouhair
authors: Z
authors: Souirti
authors: Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
authors: Nils
authors: N
authors: Wahlgren
authors: Neurology Department, Hassan II University Hospital, Fez, Morocco; Laboratory of Epidemiology and Public Health, Faculty of Medicine and Pharmacy, Sidi Mohammed BenAbdellah university Fez, Morocco.
authors: Mohammed Faouzi
authors: MF
authors: Belahsen
mesh_terms: D061605:Administration, Intravenous; D001281:Atrial Fibrillation / Q000150:complications; D002545:Brain Ischemia / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage*; D006801:Humans; D006973:Hypertension / Q000150:complications; D008297:Male; D008875:Middle Aged; D009018:Morocco; D012307:Risk Factors; D020521:Stroke / Q000188:drug therapy* / Q000209:etiology; D013997:Time Factors; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D005343:Fibrinolytic Agents; D010959:Tissue Plasminogen Activator
keywords: Intravenous thrombolysis; rt-PA; stroke