title: Intravenous fluorescein angiography-associated adverse reactions.
abstract: OBJECTIVE
  To assess (i) the adverse reactions (ARs) associated with intravenous fluorescein angiography (IVFA); (ii) the relationship between a known history of IVFA-associated AR and ARs on the subsequent IVFA test; and (iii) the dose-response relationship between intravenous sodium fluorescein (NaFl) injection and ARs associated with IVFA.
  
  
  METHODS
  Retrospective chart review.
  
  
  METHODS
  A total of 2247 patients with 3381 consecutive IVFAs between May 2013 and April 2014.
  
  
  METHODS
  Fisher's exact tests or χ2tests were used to compare the percentage difference of IVFA-associated ARs for different categorical variables. Logistic regressions were used to assess the relationship between a known history of IVFA-associated AR and any AR(s) on a subsequent IVFA test.
  
  
  RESULTS
  The overall percentage for IVFA-associated ARs was 3.3%. Adjusted for age and sex, patients who had a previous IVFA-associated AR(s) were 6.2 times more likely (adjusted odds ratio 95% CI 3.4-11.2, p < 0.0001) to have an AR compared to those who did not. Among 17 patients who had 2 repeated IVFA tests and an AR on the first IVFA test, the rate of AR on the second test was lower in patients who received a reduced dosage of NaFl (n = 14) compared to those with the standard dosage (n = 3) (35.7% vs 66.7%); however, this finding was not statistically significant (p = 0.5368).
  
  
  CONCLUSIONS
  The rate of IVFA-associated ARs in this study was low. Patients who had a known IVFA-associated AR were more likely to re-experience an AR on a subsequent test compared to those who did not. In addition, a reduced NaFl dose did not significantly reduce the chance of experiencing an AR on a subsequent test, which is likely because of the insufficient power of this comparison.
authors: Department of Ophthalmology, Hotel Dieu Hospital and Queen's University Kingston, Kingston, Ont.
authors: Kunyong
authors: K
authors: Xu
authors: Department of Ophthalmology, Hotel Dieu Hospital and Queen's University Kingston, Kingston, Ont.
authors: Velina
authors: V
authors: Tzankova
authors: Department of Ophthalmology, Hotel Dieu Hospital and Queen's University Kingston, Kingston, Ont.
authors: Cody
authors: C
authors: Li
authors: Department of Ophthalmology, Hotel Dieu Hospital and Queen's University Kingston, Kingston, Ont.. Electronic address: drsharma@insidermedicine.com.
authors: Sanjay
authors: S
authors: Sharma
mesh_terms: D000368:Aged; D002170:Canada; D004305:Dose-Response Relationship, Drug; D064420:Drug-Related Side Effects and Adverse Reactions / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D019793:Fluorescein / Q000008:administration & dosage / Q000009:adverse effects*; D005451:Fluorescein Angiography; D005456:Fluorescent Dyes / Q000008:administration & dosage / Q000009:adverse effects*; D006785:Hospitals, University; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D009325:Nausea / Q000139:chemically induced; D012189:Retrospective Studies; D014839:Vomiting / Q000139:chemically induced
chemical_list: D005456:Fluorescent Dyes; D019793:Fluorescein