title: Preoperative multiplication of neutrophil and monocyte counts as a prognostic factor in epithelial ovarian cancer.
abstract: BACKGROUND
  Epithelial ovarian cancer (EOC) is leading cause of death in gynecologic cancer, and finding prognostic factors is important for establishing treatment plans.
  
  
  OBJECTIVE
  The aim of this study was to investigate the prognostic value of the multiplication of neutrophil and monocyte counts (MNM) in epithelial ovarian cancer (EOC).
  
  
  METHODS
  Data were retrospectively collected from Samsung Medical Center for EOC patients treated from January 2002 to December 2012. MNM was determined by multiplying neutrophil and monocyte counts and dividing by 10,000. Sensitivity and specificity of markers were assessed using receiver operating characteristic curves.
  
  
  RESULTS
  We included 674 patients with EOC. For predicting overall survival (OS), the area under the curve for MNM was 0.607 (95% CI, 0.554-0.661) with sensitivity 55.2% and specificity 63.2% (cut-off value 197.40). The ability of MNM to determine OS was similar to that of the previously validated NLR and PLR. When the cohort was divided by cut-off values, poorer survival outcomes were observed in the group with higher MNM. Higher MNM was associated with advanced stage and presence of residual disease after primary treatment.
  
  
  CONCLUSIONS
  Elevated pretreatment MNM is an independent predictor of poor survival and can be a useful biomarker in patients with EOC.
authors: E Sun
authors: ES
authors: Paik
authors: Minhee
authors: M
authors: Shim
authors: Hyun Jin
authors: HJ
authors: Choi
authors: Yoo-Young
authors: YY
authors: Lee
authors: Tae-Joong
authors: TJ
authors: Kim
authors: Chel Hun
authors: CH
authors: Choi
authors: Jeong-Won
authors: JW
authors: Lee
authors: Byoung-Gie
authors: BG
authors: Kim
authors: Duk-Soo
authors: DS
authors: Bae
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000077216:Carcinoma, Ovarian Epithelial; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D008875:Middle Aged; D009000:Monocytes / Q000473:pathology*; D009375:Neoplasms, Glandular and Epithelial / Q000097:blood*; D009504:Neutrophils / Q000473:pathology*; D010051:Ovarian Neoplasms / Q000097:blood*; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D055815:Young Adult
keywords: Monocytes; biological markers; neutrophils; ovarian neoplasm; prognosis