title: Estimating relative bioavailability of soil lead in the mouse.
abstract: Lead (Pb) in soil is an important exposure source for children. Thus, determining bioavailability of Pb in soil is critical in evaluating risk and selecting appropriate strategies to minimize exposure. A mouse model was developed to estimate relative bioavailability of Pb in NIST SRM 2710a (Montana 1 Soil). Based on Pb levels in tissues, the mean relative bioavailability of this metal in this soil was 0.5. Estimates of relative bioavailabilities derived from mouse compared favorably with those obtained in juvenile swine. The mouse model is thus an efficient and inexpensive method to obtain estimates of relative bioavailability of soil Pb.
authors: a Public Health Chemistry Branch, Exposure Methods and Measurements Division , National Exposure Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency , Research Triangle Park , North Carolina , USA.
authors: Karen D
authors: KD
authors: Bradham
authors: b Pharmacokinetics Branch, Integrated Systems Toxicology Division , National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency , Research Triangle Park , North Carolina , USA.
authors: William
authors: W
authors: Green
authors: b Pharmacokinetics Branch, Integrated Systems Toxicology Division , National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency , Research Triangle Park , North Carolina , USA.
authors: Hunter
authors: H
authors: Hayes
authors: a Public Health Chemistry Branch, Exposure Methods and Measurements Division , National Exposure Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency , Research Triangle Park , North Carolina , USA.
authors: Clay
authors: C
authors: Nelson
authors: c National Research Associateship Programs , Research Triangle Park , North Carolina , USA.
authors: Pradeep
authors: P
authors: Alava
authors: d Oak Ridge Institute for Science and Education , Research Triangle Park , North Carolina , USA.
authors: John
authors: J
authors: Misenheimer
authors: e SRC Inc ., North Syracuse , New York , USA.
authors: Gary L
authors: GL
authors: Diamond
authors: e SRC Inc ., North Syracuse , New York , USA.
authors: William C
authors: WC
authors: Thayer
authors: b Pharmacokinetics Branch, Integrated Systems Toxicology Division , National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency , Research Triangle Park , North Carolina , USA.
authors: David J
authors: DJ
authors: Thomas
mesh_terms: D000818:Animals; D001682:Biological Availability; D004784:Environmental Monitoring; D005260:Female; D007854:Lead / Q000493:pharmacokinetics*; D051379:Mice; D008810:Mice, Inbred C57BL; D018570:Risk Assessment; D012989:Soil Pollutants / Q000493:pharmacokinetics*; D014018:Tissue Distribution
chemical_list: D012989:Soil Pollutants; D007854:Lead