title: Separation of antioxidant and α-glucosidase inhibitory flavonoids from the aerial parts of Asterothamnus centrali-asiaticus.
abstract: A new flavonoid, along with 16 known ones, was separated from the aerial parts of Asterothamnus centrali-asiaticus. Their structures were elucidated by extensive spectroscopic methods, including 1D and 2D NMR techniques and HRESIMS. To confirm the structure of the new compound, computational prediction of its13C chemical shifts was performed. All of the 17 flavonoids were reported from A. centrali-asiaticus for the first time. In addition, all flavonoids were evaluated for their antioxidant and α-glucosidase inhibitory activities. The results showed that 10 of them exhibited antioxidant activity. Meanwhile, four flavonoids displayed α-glucosidase inhibitory effect with IC50values ranging from 38.9 to 299.7 μM.
authors: a Key Laboratory of Chemistry of Northwestern Plant Resources of CAS and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics , Chinese Academy of Sciences , Lanzhou , P.R. China.
authors: Yan-Ming
authors: YM
authors: Wang
authors: b Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology , Chinese Academy of Sciences , Xining , P.R. China.
authors: Jian-Qiang
authors: JQ
authors: Zhao
authors: a Key Laboratory of Chemistry of Northwestern Plant Resources of CAS and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics , Chinese Academy of Sciences , Lanzhou , P.R. China.
authors: Jun-Li
authors: JL
authors: Yang
authors: b Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology , Chinese Academy of Sciences , Xining , P.R. China.
authors: Yan-Duo
authors: YD
authors: Tao
authors: b Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology , Chinese Academy of Sciences , Xining , P.R. China.
authors: Li-Juan
authors: LJ
authors: Mei
authors: a Key Laboratory of Chemistry of Northwestern Plant Resources of CAS and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics , Chinese Academy of Sciences , Lanzhou , P.R. China.
authors: Yan-Ping
authors: YP
authors: Shi
mesh_terms: D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019659:Asteraceae / Q000737:chemistry*; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D065089:Glycoside Hydrolase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D035261:Plant Components, Aerial / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D005419:Flavonoids; D065089:Glycoside Hydrolase Inhibitors
keywords: Asterothamnus centrali-asiaticus; antioxidants; flavonoids; α-glucosidase inhibitors