title: Comparing Two Different Doses of Intravenous Midazolam in Pediatric Sedation and Analgesia.
abstract: BACKGROUND
  Midazolam has turned into a common drug for pediatric procedural sedation and analgesia. However, there is not much data regarding its proper dose and potential side effects in the Iranian children population. Therefore, the present study was done to compare 2 doses of IV midazolam in this regard.
  
  
  METHODS
  The present clinical trial was performed to compare 0.1 and 0.3 mg/kg doses of IV midazolam in induction of sedation for head trauma infant patients in need of brain computed tomography (CT) scan. Conscious infants under 2 years old, with stable hemodynamics were included. Onset and duration of action as well as probable side effects were compared between the two groups using SPSS version 22.
  
  
  RESULTS
  110 infants with the mean age of 14.0 ± 5.9 months (range: 4 - 24) and mean weight of 9.7 ± 2 kg (range: 5 - 15) were randomly allocated to one of the 2 study groups (54.6% female). Success rate in 0.1 and 0.3 mg/kg groups were 38.2% (21 patients) and 60% (33 patients), respectively (p = 0.018). Overall, 56 (50.9%) patients did not reach proper sedation and were sedated receiving ketamine (22 patients) or another dose of midazolam (34 patients, mean additional dose needed was 2.1 ± 1.1 mg).
  
  
  CONCLUSIONS
  The results of the present study demonstrated the higher success rate and longer duration of action for 0.3 mg/kg midazolam compared to 0.1 mg/kg. The groups were equal regarding onset of action, effect on vital signs and probable side effects.
authors: Department of EmergencyMedicine, Imam Khomeini General Hospital, Ahvaz Jundishapur University ofMedical Sciences, Ahvaz, Iran.
authors: Hassan
authors: H
authors: Barzegari
authors: Department of EmergencyMedicine, Imam Khomeini General Hospital, Ahvaz Jundishapur University ofMedical Sciences, Ahvaz, Iran.
authors: Kambiz
authors: K
authors: Masoumi
authors: Department of EmergencyMedicine, Imam Khomeini General Hospital, Ahvaz Jundishapur University ofMedical Sciences, Ahvaz, Iran.
authors: Hassan
authors: H
authors: Motamed
authors: Road trauma Research Center, Guilan University ofMedical Sciences, Rasht, Iran.
authors: Behzad
authors: B
authors: Zohrevandi
authors: Department of EmergencyMedicine, Imam Khomeini General Hospital, Ahvaz Jundishapur University ofMedical Sciences, Ahvaz, Iran.
authors: Shima
authors: S
authors: Zeynadini Meymand
keywords: Midazolam; conscious sedation; dose-response relationship; drug; emergency service; hospital; infant