title: Tyrosinase inhibitory components from Aloe vera and their antiviral activity.
abstract: A new compound, 9-dihydroxyl-2'-O-(Z)-cinnamoyl-7-methoxy-aloesin (1), and eight known compounds (2-9) were isolated from Aloe vera. Their structures were elucidated using 1D/2D nuclear magnetic resonance and mass spectra. Compound 9 exhibited reversible competitive inhibitory activity against the enzyme tyrosinase, with an IC50value of 9.8 ± 0.9 µM. A molecular simulation revealed that compound 9 interacts via hydrogen bonding with residues His244, Thr261, and Val283 of tyrosinase. Additionally, compounds 3 and 7 were shown by half-leaf assays to exhibit inhibitory activity towards Pepper mild mottle virus.
authors: a Department of Horticultural and Crop Environment , National Institute of Horticultural and Herbal Science, RDA , Wanju , Republic of Korea.
authors: Jang Hoon
authors: JH
authors: Kim
authors: a Department of Horticultural and Crop Environment , National Institute of Horticultural and Herbal Science, RDA , Wanju , Republic of Korea.
authors: Ju-Yeon
authors: JY
authors: Yoon
authors: b College of Pharmacy, Chungnam National University , Daejeon , Republic of Korea.
authors: Seo Young
authors: SY
authors: Yang
authors: a Department of Horticultural and Crop Environment , National Institute of Horticultural and Herbal Science, RDA , Wanju , Republic of Korea.
authors: Seung-Kook
authors: SK
authors: Choi
authors: a Department of Horticultural and Crop Environment , National Institute of Horticultural and Herbal Science, RDA , Wanju , Republic of Korea.
authors: Sun Jung
authors: SJ
authors: Kwon
authors: a Department of Horticultural and Crop Environment , National Institute of Horticultural and Herbal Science, RDA , Wanju , Republic of Korea.
authors: In Sook
authors: IS
authors: Cho
authors: b College of Pharmacy, Chungnam National University , Daejeon , Republic of Korea.
authors: Min Hee
authors: MH
authors: Jeong
authors: b College of Pharmacy, Chungnam National University , Daejeon , Republic of Korea.
authors: Young
authors: Y
authors: Ho Kim
authors: a Department of Horticultural and Crop Environment , National Institute of Horticultural and Herbal Science, RDA , Wanju , Republic of Korea.
authors: Gug Seoun
authors: GS
authors: Choi
mesh_terms: D000504:Aloe / Q000737:chemistry*; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D066241:Carbon-13 Magnetic Resonance Spectroscopy; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D062105:Molecular Docking Simulation; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors*; D010936:Plant Extracts / Q000494:pharmacology*; D010942:Plant Viruses / Q000187:drug effects; D066244:Proton Magnetic Resonance Spectroscopy; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D000998:Antiviral Agents; D004791:Enzyme Inhibitors; D010936:Plant Extracts; D014442:Monophenol Monooxygenase
keywords: Aloe vera; Pepper mild mottle virus; Xanthorrhoeaceae; molecular docking; tyrosinase