title: Auraptene and Its Role in Chronic Diseases.
abstract: Auraptene (7-geranyloxycoumarin) is the best known and most abundant prenyloxycoumarin present in nature. It is synthesized by various plant species, mainly those of the Rutaceae and Umbeliferae (Apiaceae) families, comprising many edible fruits and vegetables such as lemons, grapefruit and orange. Auraptene has shown a remarkable effect in the prevention of degenerative diseases, in particular it has been reported to be one the most promising known natural chemopreventive agents against several types of cancer. The aim of this chapter is to review the effects of auraptene in the prevention and treatment of different chronic diseases.
authors: Department of Internal Medicine and Therapeutics, University of Pavia, Fondazione IRCCS Policlinico San Matteo, P.le C. Golgi, 2-27100, Pavia, Italy. giuseppe.derosa@unipv.it.|Center for Prevention, Surveillance, Diagnosis and Treatment of Rare Diseases, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy. giuseppe.derosa@unipv.it.|Center for the Study of Endocrine-Metabolic Pathophysiology and Clinical Research, University of Pavia, Pavia, Italy. giuseppe.derosa@unipv.it.|Laboratory of Molecular Medicine, University of Pavia, Pavia, Italy. giuseppe.derosa@unipv.it.
authors: Giuseppe
authors: G
authors: Derosa
authors: Department of Internal Medicine and Therapeutics, University of Pavia, Fondazione IRCCS Policlinico San Matteo, P.le C. Golgi, 2-27100, Pavia, Italy.|Center for Prevention, Surveillance, Diagnosis and Treatment of Rare Diseases, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.|PhD School in Experimental Medicine, University of Pavia, Pavia, Italy.
authors: Pamela
authors: P
authors: Maffioli
authors: Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. sahebkara@mums.ac.ir.|School of Medicine and Pharmacology, Metabolic Research Centre, Royal Perth Hospital, University of Western Australia, Perth, Australia. sahebkara@mums.ac.ir.|Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, P.O. Box: 91779-48564, Mashhad, Iran. sahebkara@mums.ac.ir.
authors: Amirhossein
authors: A
authors: Sahebkar
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000627:therapeutic use*; D000959:Antihypertensive Agents / Q000737:chemistry / Q000627:therapeutic use*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000627:therapeutic use*; D002908:Chronic Disease / Q000188:drug therapy*; D003374:Coumarins / Q000737:chemistry / Q000627:therapeutic use*; D055808:Drug Discovery / Q000379:methods*; D006801:Humans; D000960:Hypolipidemic Agents / Q000737:chemistry / Q000627:therapeutic use*; D018696:Neuroprotective Agents / Q000737:chemistry / Q000627:therapeutic use*; D008517:Phytotherapy; D010946:Plants, Medicinal
chemical_list: D000893:Anti-Inflammatory Agents; D000959:Antihypertensive Agents; D000972:Antineoplastic Agents, Phytogenic; D003374:Coumarins; D000960:Hypolipidemic Agents; D018696:Neuroprotective Agents; C105832:aurapten
keywords: Auraptene; Chemoprevention; Degenerative diseases; Hypertension; Lipid profile