title: Personalized microbiome-based approaches to metabolic syndrome management and prevention.
abstract: Personalized or precision medicine is a novel clinical approach targeted to the individual patient and based on integration of clinical, genetic, and environmental factors that define a patient uniquely from other individuals featuring similar clinical symptoms. Such a personalized medicine approach is increasingly applied for diagnosis, clinical stratification, and treatment of metabolic syndrome (MetS)-associated risks and diseases, including obesity, type 2 diabetes, non-alcoholic fatty liver disease, and their complications. One emerging factor that governs MetS manifestations is the microbiome, the composition, function, growth dynamics, associated metabolite profile and diverse effects of which on host immune and metabolic systems can all significantly affect metabolic homeostasis. Interindividual differences in microbiome composition and function, as well as personal variations in microbial-derived products, pave the way towards microbiome-based personalized medicine in treating MetS-related diseases.
authors: Department of Immunology, Weizmann Institute of Science, Rehovot, Israel.
authors: Hagit
authors: H
authors: Shapiro
authors: Department of Immunology, Weizmann Institute of Science, Rehovot, Israel.
authors: Jotham
authors: J
authors: Suez
authors: Department of Immunology, Weizmann Institute of Science, Rehovot, Israel.
authors: Eran
authors: E
authors: Elinav
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000517:prevention & control / Q000628:therapy; D005243:Feces / Q000382:microbiology; D000069196:Gastrointestinal Microbiome / Q000502:physiology*; D006801:Humans; D024821:Metabolic Syndrome / Q000517:prevention & control* / Q000628:therapy*; D065626:Non-alcoholic Fatty Liver Disease / Q000517:prevention & control / Q000628:therapy; D009765:Obesity / Q000517:prevention & control / Q000628:therapy; D056692:Prebiotics / Q000008:administration & dosage; D057285:Precision Medicine / Q000379:methods* / Q000639:trends; D019936:Probiotics / Q000008:administration & dosage
chemical_list: D056692:Prebiotics
keywords: metabolic syndrome; microbiome; personalized medicine; 代谢综合征,微生物,个体化治疗