title: Nuclear Imaging in Metastatic Paraganglioma.
abstract: Paragangliomas associated with mutations of the SDHD gene can occasionally result in distant metastasis. Diagnosis can be difficult, and nuclear imaging is used to evaluate the case further. Not all tumors are alike; nuclear avidity may differ. We present a case in which metastatic paraganglioma caused by mutations of the SDHD gene was negative on123I-metaiodobenzylguanidine scintigraphy and positive on111In-labeled octreotide scintigraphy. This situation presents an opportunity for a novel therapeutic approach toward metastatic paraganglioma using targeted peptide receptor radionuclide therapy.
authors: Division of DEM, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska; and rohitkediado@gmail.com.
authors: Rohit
authors: R
authors: Kedia
authors: Department of Radiology, University of Nebraska Medical Center, Omaha, Nebraska.
authors: Neil
authors: N
authors: Hansen
authors: Division of DEM, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska; and.
authors: Whitney
authors: W
authors: Goldner
mesh_terms: D005260:Female; D006801:Humans; D008875:Middle Aged; D064847:Multimodal Imaging; D009154:Mutation; D009362:Neoplasm Metastasis; D010235:Paraganglioma / Q000000981:diagnostic imaging* / Q000235:genetics / Q000473:pathology*; D013385:Succinate Dehydrogenase / Q000235:genetics
chemical_list: C491545:SDHD protein, human; D013385:Succinate Dehydrogenase
keywords: neuroendocrine tumor; paraganglioma; peptide receptor therapy