title: Neural markers of attention to aversive pictures predict response to cognitive behavioral therapy in anxiety and depression.
abstract: Excessive attention toward aversive information may be a core mechanism underlying emotional disorders, but little is known about whether this is predictive of response to treatments. We evaluated whether enhanced attention toward aversive stimuli, as indexed by an event-related potential component, the late positive potential (LPP), would predict response to cognitive behavioral therapy (CBT) in patients with social anxiety disorder and/or major depressive disorder. Thirty-two patients receiving 12 weeks of CBT responded to briefly-presented pairs of aversive and neutral pictures that served as targets or distracters while electroencephaolography was recorded. Patients with larger pre-treatment LPPs to aversive relative to neutral distracters (when targets were aversive) were more likely to respond to CBT, and demonstrated larger reductions in symptoms of depression and anxiety following treatment. Increased attention toward irrelevant aversive stimuli may signal attenuated top-down control, so treatments like CBT that improve this control could be beneficial for these individuals.
authors: Department of Psychiatry, University of Illinois at Chicago, 1747 W. Roosevelt Rd., Chicago, IL 60608, USA. Electronic address: jstange@psych.uic.edu.
authors: Jonathan P
authors: JP
authors: Stange
authors: Department of Psychology, Texas A&M University, 4235 TAMU, College Station, TX 77840, USA.
authors: Annmarie
authors: A
authors: MacNamara
authors: Department of Psychiatry, University of Illinois at Chicago, 1747 W. Roosevelt Rd., Chicago, IL 60608, USA.
authors: Olga
authors: O
authors: Barnas
authors: Department of Psychiatry, University of Illinois at Chicago, 1747 W. Roosevelt Rd., Chicago, IL 60608, USA; Mental Health Service Line, Jesse Brown VA Medical Center, 820 S. Damen Ave., Chicago, IL 60612, USA.
authors: Amy E
authors: AE
authors: Kennedy
authors: Department of Psychology, Stony Brook University, Psychology B Building, Stony Brook, NY 11794, USA.
authors: Greg
authors: G
authors: Hajcak
authors: Department of Psychiatry, University of Illinois at Chicago, 1747 W. Roosevelt Rd., Chicago, IL 60608, USA; Mental Health Service Line, Jesse Brown VA Medical Center, 820 S. Damen Ave., Chicago, IL 60612, USA; Department of Psychology, University of Illinois at Chicago, 1007 W. Harrison St., Chicago, IL 60607, USA; Department of Anatomy and Cell Biology, and the Graduate Program in Neuroscience, University of Illinois at Chicago, 808 S. Wood St., Chicago, IL 60612, USA.
authors: K Luan
authors: KL
authors: Phan
authors: Department of Psychiatry, University of Illinois at Chicago, 1747 W. Roosevelt Rd., Chicago, IL 60608, USA; Department of Psychology, University of Illinois at Chicago, 1007 W. Harrison St., Chicago, IL 60607, USA. Electronic address: hklumpp@psych.uic.edu.
authors: Heide
authors: H
authors: Klumpp
mesh_terms: D000293:Adolescent; D000328:Adult; D000339:Affect / Q000502:physiology*; D001288:Attention / Q000502:physiology*; D015415:Biomarkers / Q000032:analysis; D015928:Cognitive Behavioral Therapy / Q000379:methods*; D003865:Major Depressive Disorder / Q000503:physiopathology / Q000523:psychology* / Q000628:therapy; D004569:Electroencephalography; D005071:Evoked Potentials / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000072861:Phobia, Social / Q000503:physiopathology / Q000523:psychology* / Q000628:therapy; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D015415:Biomarkers
keywords: CBT; Event-related potentials; Internalizing disorders; Transdiagnostic; Treatment prediction