title: Regulation of gene expression in human cancers by TRIM24.
abstract: Tripartite Motif-containing protein 24 (TRIM24) functions as an E3 ligase targeting p53 for ubiquitination, a histone 'reader' that interacts with a specific signature of histone post-translational modifications and a co-regulator of nuclear receptor-regulated transcription. Although mouse models of Trim24 depletion suggest that TRIM24 may be a liver-specific tumor suppressor, several studies show that human TRIM24 is an oncogene when aberrantly over expressed. This review focuses on the mechanisms of TRIM24 functions in oncogenesis and metabolic reprogramming, which underlie recent interest in therapeutic targeting of aberrant TRIM24 in human cancers.
authors: Department of Epigenetics and Molecular Carcinogenesis, Center for Cancer Epigenetics, Houston, TX 77030, USA.
authors: Srikanth
authors: S
authors: Appikonda
authors: Department of Epigenetics and Molecular Carcinogenesis, Center for Cancer Epigenetics, Houston, TX 77030, USA; University of Texas Graduate School of Biomedical Sciences at Houston, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
authors: Kaushik N
authors: KN
authors: Thakkar
authors: Department of Epigenetics and Molecular Carcinogenesis, Center for Cancer Epigenetics, Houston, TX 77030, USA; University of Texas Graduate School of Biomedical Sciences at Houston, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address: mbarton@mdanderson.org.
authors: Michelle Craig
authors: MC
authors: Barton
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism*; D002843:Chromatin / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism; D015513:Oncogene Proteins / Q000378:metabolism*
chemical_list: D002352:Carrier Proteins; D002843:Chromatin; D015513:Oncogene Proteins; C555317:TRIM24 protein, human