title: Subcapsular Implantation of Pancreatic Islets in Syngeneic, Allogeneic, and Xenogeneic Mice.
abstract: BACKGROUND
  Reliable and reproducible transplantation is essential to the success of a number of particular investigations. Renal subcapsule is the most selected site for islet transplantation mainly owing to its easy access, readiness for retrieval, and possibility of reimplantation.
  
  
  METHODS
  Syngeneic, allogeneic, and xenogeneic islets were transplanted into kidney capsules of Balb/C and C57BL/6J mice, and the blood glucose levels of the experimental animals were periodically monitored. Detailed procedures on mouse diabetic model and islet implantation are described.
  
  
  RESULTS
  The values of blood glucose measured under varied transplant circumstances are presented, covering syngeneic, allogeneic, and xenogeneic islet transplantations. The methodology is straightforward and has been proven to be practicable and reproducible.
  
  
  CONCLUSIONS
  The parallel observations in different transplant situations provide a valuable contribution to and useful information for diabetes-related studies.
authors: Hubei Key Laboratory of Embryonic Stem Cell Research, Taihe Hospital, Hubei University of Medicine, Shiyan, People's Republic of China.
authors: S-N
authors: SN
authors: Ma
authors: Hubei Key Laboratory of Embryonic Stem Cell Research, Taihe Hospital, Hubei University of Medicine, Shiyan, People's Republic of China.
authors: Y-H
authors: YH
authors: Yuan
authors: Hubei Key Laboratory of Embryonic Stem Cell Research, Taihe Hospital, Hubei University of Medicine, Shiyan, People's Republic of China.
authors: X-R
authors: XR
authors: Guo
authors: Hubei Key Laboratory of Embryonic Stem Cell Research, Taihe Hospital, Hubei University of Medicine, Shiyan, People's Republic of China. Electronic address: dsli1698@126.com.
authors: D-S
authors: DS
authors: Li
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D050476:Bowman Capsule; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000628:therapy; D004195:Disease Models, Animal; D005260:Female; D007515:Islets of Langerhans / Q000502:physiology; D016381:Islets of Langerhans Transplantation / Q000379:methods*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D060053:Transplant Donor Site; D014183:Transplantation, Heterologous; D014184:Transplantation, Homologous; D014185:Transplantation, Isogeneic
chemical_list: D001786:Blood Glucose