title: A highly sensitive and selective electrochemical determination of non-steroidal prostate anti-cancer drug nilutamide based on f-MWCNT in tablet and human blood serum sample.
abstract: A novel electrochemical sensor based on the functionalized multiwalled carbon nanotube (f-MWCNT) was successfully developed for the sensitive and selective determination of non-steroidal prostate anti-cancer drug nilutamide in tablet and blood serum samples. The f-MWCNT was prepared by the simple reflux method and characterized by the scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), Raman spectroscopy, X-ray powder diffraction (XRD) and fourier transform infrared spectroscopy (FT-IR). Interestingly, the f-MWCNT was exhibited a superior electrocatalytic activity towards the anti-cancer drug nilutamide when compared with pristine MWCNT and unmodified electrodes. Besides, the electrochemical sensor was revealed an excellent current response for the determination of nilutamide with wide linear ranges (0.01-21μM and 28-535μM), high sensitivity (11.023 and 1.412μA μM-1cm2) and very low detection limit (LOD) 0.2nM. The developed electrochemical sensor was showed an excellent selectivity even in the presence of electrochemically active biological substances and nitro aromatic compounds. Moreover, it manifested a good reproducibility and stability. In addition, the f-MWCNT modified glassy carbon electrode (GCE) sensor was successfully applied for the detection of nilutamide in tablet and blood serum sample.
authors: Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei 106, Taiwan, ROC.
authors: R
authors: R
authors: Karthik
authors: Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei 106, Taiwan, ROC.
authors: R
authors: R
authors: Sasikumar
authors: Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei 106, Taiwan, ROC; Department of Botany and Microbiology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia. Electronic address: smchen78@ms15.hinet.net.
authors: Shen-Ming
authors: SM
authors: Chen
authors: Department of Chemistry, VHNSN College, Virudhunagar 626001, Tamil Nadu, India.
authors: J
authors: J
authors: Vinoth Kumar
authors: Department of Chemistry, Thiagarajar College, Madurai 625009, Tamil Nadu, India.
authors: A
authors: A
authors: Elangovan
authors: Department of Chemistry, VHNSN College, Virudhunagar 626001, Tamil Nadu, India.
authors: V
authors: V
authors: Muthuraj
authors: Department of Chemistry, Faculty of Engineering, Karpagam University, Coimbatore 641021, India.
authors: P
authors: P
authors: Muthukrishnan
authors: Department of Botany and Microbiology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.
authors: Fahad M A
authors: FMA
authors: Al-Hemaid
authors: Department of Botany and Microbiology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.
authors: M
authors: M
authors: Ajmal Ali
authors: Department of Botany and Microbiology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.
authors: Mohamed S
authors: MS
authors: Elshikh
mesh_terms: D000726:Androgen Antagonists / Q000097:blood*; D000970:Antineoplastic Agents / Q000097:blood*; D015374:Biosensing Techniques; D055664:Electrochemical Techniques; D004566:Electrodes; D006801:Humans; D048289:Imidazolidines / Q000097:blood*; D057230:Limit of Detection; D037742:Nanotubes, Carbon / Q000737:chemistry* / Q000648:ultrastructure; D015203:Reproducibility of Results; D013607:Tablets
chemical_list: D000726:Androgen Antagonists; D000970:Antineoplastic Agents; D048289:Imidazolidines; D037742:Nanotubes, Carbon; D013607:Tablets; C021277:nilutamide
keywords: Electrochemical sensor; Nilutamide; Serum sample; Tablet; f-MWCNT