title: In the Red: Deficits in Immune Regulation Underlie Psoriasis Severity.
abstract: IL-17-driven pathways are active in the skin of patients with psoriasis. Kim et al. examined lesions from mild and moderate to severe psoriasis and found that differences in cutaneous disease severity may be the outcome of lapses in immunoregulatory mechanisms; because as much, if not more, T helper type 17-induced inflammation was seen in mild psoriasis, these patients may also benefit from anti-IL-17-targeted biologics.
authors: Department of Dermatology, University of Michigan, Ann Arbor, Michigan, USA. Electronic address: andjoh@med.umich.edu.
authors: Andrew
authors: A
authors: Johnston
mesh_terms: D006801:Humans; D007111:Immunity, Cellular; D020381:Interleukin-17 / Q000378:metabolism*; D011565:Psoriasis / Q000175:diagnosis / Q000276:immunology / Q000378:metabolism; D012720:Severity of Illness Index; D012867:Skin / Q000276:immunology / Q000473:pathology*; D058504:Th17 Cells / Q000276:immunology*
chemical_list: D020381:Interleukin-17