title: The role of 68Ga-DOTA-TATE PET/CT scanning in the evaluation of patients with multiple myeloma: preliminary results.
abstract: OBJECTIVE
  In this observational pilot study, we aimed to evaluate the role of gallium-68-labelled DOTA-TATE (Ga-TATE) PET/computed tomography (CT) scanning in patients with multiple myeloma (MM), considering previous promising results obtained from conventional somatostatin receptor scintigraphy with In pentetreotide.
  
  
  METHODS
  Twenty-one patients with a diagnosis of MM were prospectively included in this study: eight patients were referred for initial staging and 13 patients for restaging purpose. Both fluorine-18 fluorodeoxyglucose (F-FDG) and TATE PET/CT scanning were performed in all patients.
  
  
  RESULTS
  All patients had one or more PET-positive lesion on either F-FDG or TATE scans. Six patients had an additional diffusely increased bone marrow activity on F-FDG scans, five of whom also had a concordant bone marrow appearance on TATE scans. Each PET set (either F-FDG or TATE) was positive in 19 patients. There was a discordant result in four (19%) patients between F-FDG and TATE scans. F-FDG scans showed 112 lesions (86 TATE-positive; 26 TATE-negative) in 19 patients, whereas TATE scans showed 108 lesions (86 F-FDG-positive; 22 F-FDG-negative) in 19 patients. No significant difference was found between the two modalities in terms of lesion numbers detected (P=0.67). However, the presence of diffuse bone marrow uptake of TATE seems to be a predicting factor for the overall survival (P=0.033, hazard ratio: 15.2 and 95% confidence interval: 1.2-185.5).
  
  
  CONCLUSIONS
  TATE PET/CT seems to be an alternative imaging modality and may play a complementary role in MM management, at least by providing a different pathobiological insight into the disease.
authors: aDepartment of Nuclear Medicine bDepartment of Internal Medicine, Haematology Division, Cerrahpasa Medical Faculty cDepartment of Pharmaceutical Technology, Faculty of Pharmacy, Istanbul University dSisli Etfal Education and Training Hospital, Istanbul eDepartment of Nuclear Medicine, Medical Faculty, Konuralp, Duzce University, Duzce, Turkey.
authors: Kerim
authors: K
authors: Sonmezoglu
authors: Betul
authors: B
authors: Vatankulu
authors: Tugrul
authors: T
authors: Elverdi
authors: Resit
authors: R
authors: Akyel
authors: Melih E
authors: ME
authors: Erkan
authors: Metin
authors: M
authors: Halac
authors: Meltem
authors: M
authors: Ocak
authors: Emre
authors: E
authors: Demirci
authors: Yildiz
authors: Y
authors: Aydin
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D005710:Gallium Radioisotopes; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000000981:diagnostic imaging*; D009942:Organometallic Compounds; D000072078:Positron Emission Tomography Computed Tomography / Q000379:methods* / Q000706:statistics & numerical data; D011446:Prospective Studies; D019275:Radiopharmaceuticals
chemical_list: D005462:Fluorine Radioisotopes; D005710:Gallium Radioisotopes; D009942:Organometallic Compounds; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; C513399:gallium Ga 68 dotatate