title: Characteristics of Factors of Protozoa Blastocystis hominis Persistence.
abstract: Persistence activity manifested in the expression of anti-lysozyme, anti-lactoferrin, and antihistone factors promoting inactivation of natural anti-infection resistance factors in the body was revealed in Blastocystis hominis protozoa. Activities of these factors were ranged. The frequency of these factors in clinical isolates of blastocyst decreased in the following order: anti-lactoferrin activity (84.5±3.7%)→anti-lysozyme activity (64.8±5.7%)→anti-histone activity (48.1±2.3%). In healthy humans, the corresponding parameters were 7.3±1.3, 5.3±0.9, and 3.3±0.4%, respectively (p<0.05). It was shown that the studied activities in highly virulent blastocysts were higher than in groups of medium-, low-, and avirulent protozoa.
authors: Department of General and Clinical Pharmacology with Microbiology Course, Ulyanovsk State University, Ulyanovsk, Russia. sgmikm@gmail.com.
authors: N I
authors: NI
authors: Potaturkina-Nesterova
authors: Department of General and Clinical Pharmacology with Microbiology Course, Ulyanovsk State University, Ulyanovsk, Russia.|I. N. Ulyanov Ulyanovsk State Pedagogical University, Ulyanovsk, Russia.
authors: N A
authors: NA
authors: Il'ina
authors: Department of General and Clinical Pharmacology with Microbiology Course, Ulyanovsk State University, Ulyanovsk, Russia.|I. N. Ulyanov Ulyanovsk State Pedagogical University, Ulyanovsk, Russia.
authors: N V
authors: NV
authors: Bugero
authors: Department of General and Clinical Pharmacology with Microbiology Course, Ulyanovsk State University, Ulyanovsk, Russia.
authors: A S
authors: AS
authors: Nesterov
mesh_terms: D000818:Animals; D016776:Blastocystis Infections / Q000469:parasitology* / Q000473:pathology; D016845:Blastocystis hominis / Q000254:growth & development / Q000302:isolation & purification / Q000472:pathogenicity*; D005243:Feces / Q000469:parasitology; D006657:Histones / Q000037:antagonists & inhibitors; D006790:Host-Parasite Interactions; D006801:Humans; D007274:Injections, Intraperitoneal; D007781:Lactoferrin / Q000037:antagonists & inhibitors; D007928:Lethal Dose 50; D051379:Mice; D009113:Muramidase / Q000037:antagonists & inhibitors; D014774:Virulence; D037521:Virulence Factors / Q000096:biosynthesis* / Q000494:pharmacology
chemical_list: D006657:Histones; D037521:Virulence Factors; D009113:Muramidase; D007781:Lactoferrin
keywords: Blastocystis spp; anti-histone activity; anti-lactoferrin activity; anti-lysozyme activity; virulence