title: Novel targets of omalizumab in asthma.
abstract: Omalizumab is a recombinant humanized anti-IgE monoclonal antibody approved in the US for moderate to severe persistent allergic asthma (severe persistent asthma in the European Union), uncontrolled despite treatment with inhaled corticosteroids and long-acting beta2 agonists. It reduces asthma exacerbations, symptoms, oral corticosteroid doses, and improves quality of life.
  
  
  
  Omalizumab may have an antiviral effect when used as a preventive therapy for fall exacerbations in children and teenagers. Two proof-of-concept studies have evaluated omalizumab in nonatopic asthma and showed that it is safe and possibly efficacious in some patients. Omalizumab has been successfully studied as add-on to specific immunotherapy in moderate allergic asthma. Its safety in pregnancy has been assessed in the EXPECT registry. Case series also report positive effects in cases of allergic bronchopulmonary aspergillosis, and in nasal disorders frequently associated with asthma. Last, omalizumab may have corticosteroid-sparing effect in a subset of patients with eosinophilic granulomatosis with polyangiitis (formerly Churg-Strauss syndrome).
  
  
  
  Recent studies argue in favor of positive effects of omalizumab beyond its current indications in asthma. Well-designed studies are needed in order to demonstrate the safety and efficacy of omalizumab in these possible novel indications.
authors: aUniv Paris-Sud, Faculté de Médecine, Université Paris-Saclay bAP-HP, Service de Pneumologie, Hôpital Bicêtre cAPHP, Service de Physiologie, Explorations Fonctionnelles Respiratoires, Hôpital Bicêtre, Le Kremlin-Bicêtre dInserm UMR_S 999, Hôpital Marie Lannelongue, Le Plessis-Robinson, France.
authors: Caroline
authors: C
authors: Sattler
authors: Gilles
authors: G
authors: Garcia
authors: Marc
authors: M
authors: Humbert
mesh_terms: D018927:Anti-Asthmatic Agents / Q000627:therapeutic use*; D001229:Aspergillosis, Allergic Bronchopulmonary / Q000188:drug therapy; D001249:Asthma / Q000188:drug therapy*; D006801:Humans; D000069444:Omalizumab / Q000627:therapeutic use*; D011788:Quality of Life; D016896:Treatment Outcome
chemical_list: D018927:Anti-Asthmatic Agents; D000069444:Omalizumab