title: Host Gene Polymorphisms in Relation to Helicobacter Pylori Infection and Associated Diseases in a Population Based Cohort.
abstract: BACKGROUND
  This prospective population based cohort study explores possible associations between host gene polymorphisms, blood group and life style factors on the one hand, andHelicobacter pyloriinfection, peptic ulcer, and the grade of inflammation, atrophy and intestinal metaplasia of the gastric mucosa, on the other hand.
  
  
  METHODS
  The study population (472 volunteers) has previously undergone screening with gastroduodenoscopy, biopsy and blood sampling. The host gene polymorphisms of IL1B-31C/T, IFNGR1-56T/C, the IL1RN VNTR in exon 2 and the HLA-DRB1 gene alleles were analyzed using PCR and pyrosequencing.
  
  
  RESULTS
  H. pyloriinfection was negatively related to HLA DRB1*03 (odds ratio (OR) 95% CI: 0.388 - 0.989) and was more frequent in individuals with blood group O than A (OR 95% CI: 1.121 - 2.677). There was a lower risk of moderate to severe inflammation in the antrum among individuals with IL1B-31 TC compared to CC carriers (OR 95% CI: 0.094 - 0.733). The IL1RN*L2 genotype was associated with higher risk of IM in the antrum than the *LL genotype (OR 95% CI: 1.570 - 15.878). There was a negative relation between the HLA DRB1 alleles *04 (OR 95% CI: 0.234 - 0.831) and *08 (OR 95% CI: 0.013 - 0.915), and IM in the antrum.
  
  
  CONCLUSIONS
  The IL1RN VNTR and the IL1β-31 alleles seem to be associated with intestinal metaplasia of the corpus mucosa and the grade of inflammation of the antrum, respectively. However, no unambiguous correlations could be identified between the host polymorphisms and the occurrence ofH. pyloriinfection, peptic ulcer, and the grade of inflammation, atrophy and IM of the gastric mucosa.
authors: Department of Clinical Microbiology, Centre for Diagnostics, County Council of Ostergotland, Sweden; Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linkoping University, Sweden.
authors: Anna
authors: A
authors: Ryberg
authors: Department of Pathology, National University Health System Singapore. Previously Department of Pathology, Karolinska University Hospital, Stockholm, Sweden.
authors: Fredrik
authors: F
authors: Petersson
authors: Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linkoping University, Sweden.
authors: Stefan
authors: S
authors: Redeen
authors: Department of Computer and Information Science, Faculty of Arts and Sciences, Linkoping University, Sweden.
authors: Olle
authors: O
authors: Eriksson
authors: Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linkoping University, Sweden.
authors: Kurt
authors: K
authors: Borch
keywords: Atrophy; Gastritis; Peptic ulcer; Pyrosequencing; Stomach