title: Development of the Japanese Version of the Leeds Assessment of the Neuropathic Symptoms and Signs Pain Scale: Diagnostic Utility in a Clinical Setting.
abstract: We aimed to assess the diagnostic utility of the linguistically validated Japanese version of the Leeds Assessment of Neuropathic Symptoms and Signs Pain Scale (LANSS-J) as a screening tool for neuropathic pain in the clinical setting.
  
  
  
  Patients with neuropathic pain or nociceptive pain who were 20 to 85 years of age were included. Sensitivity and specificity using the original cutoff value of 12 were assessed to evaluate the diagnostic utility of the LANSS-J. Sensitivity and specificity with possible cutoff values were calculated, along with area under the receiver operating characteristic curve. We then evaluated agreement regarding assessment of the LANSS-J by two investigators. We used the intraclass correlation coefficient (ICC) for the total score and Cohen's kappa coefficient for each item.
  
  
  
  Data for patients with neuropathic pain (n = 30) and those with nociceptive pain (n = 29) were analyzed. With a cutoff of 12, the sensitivity was 63.3% (19/30) and the specificity 93.1% (27/29). Sensitivity improved substantially with a cutoff of ≤ 11 (≥ 83.3%, 25/30). High specificity (93.1%, 27/29) was sustained with a cutoff of 9 to 12. The ICC for the total score was 0.85, indicating sufficient agreement. Kappa coefficients ranged from 0.68 to 0.84.
  
  
  
  The LANSS-J is a valid screening tool for detecting neuropathic pain. Our results suggest that employing the original cutoff value provides high specificity, although a lower cutoff value of 10 or 11 (with its high specificity maintained) may be more beneficial when pain attributed to neuropathic mechanisms is suspected in Japanese patients.
authors: Clinical Study Support Inc., Nagoya, Japan.|Institute of Medical Science, Tokyo Medical University, Tokyo, Japan.
authors: Tatsuya
authors: T
authors: Isomura
authors: Department of Pain and Palliative Medicine, The University of Tokyo Hospital, Tokyo, Japan.
authors: Masahiko
authors: M
authors: Sumitani
authors: Department of Medical Research and Management for Musculoskeletal Pain, 22nd Century Medical and Research Center, Faculty of Medicine, The University of Tokyo Hospital, Tokyo, Japan.
authors: Ko
authors: K
authors: Matsudaira
authors: Clinical Study Support Inc., Nagoya, Japan.
authors: Mika
authors: M
authors: Kawaguchi
authors: Department of Pain and Palliative Medicine, The University of Tokyo Hospital, Tokyo, Japan.
authors: Reo
authors: R
authors: Inoue
authors: Department of Pain and Palliative Medicine, The University of Tokyo Hospital, Tokyo, Japan.
authors: Jun
authors: J
authors: Hozumi
authors: Orthopaedic Surgery in Sensory and Motor System Medicine, Division of Surgical Science, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
authors: Takeyuki
authors: T
authors: Tanaka
authors: Division of Science for Joint Reconstruction, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
authors: Hirofumi
authors: H
authors: Oshima
authors: Orthopaedic Surgery in Sensory and Motor System Medicine, Division of Surgical Science, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
authors: Kanto
authors: K
authors: Mori
authors: Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
authors: Shuji
authors: S
authors: Taketomi
authors: Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
authors: Hiroshi
authors: H
authors: Inui
authors: Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
authors: Keitaro
authors: K
authors: Tahara
authors: Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
authors: Ryota
authors: R
authors: Yamagami
authors: Pfizer Japan Inc., Tokyo, Japan.
authors: Kazuhiro
authors: K
authors: Hayakawa
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009437:Neuralgia / Q000175:diagnosis* / Q000453:epidemiology*; D010147:Pain Measurement / Q000379:methods* / Q000592:standards* / Q000639:trends; D015203:Reproducibility of Results; D011795:Surveys and Questionnaires; D014175:Translating
keywords: Japanese version; Leeds Assessment of Neuropathic Symptoms and Signs Pain Scale; diagnostic utility; neuropathic pain; screening tools