title: Multicomponent pattern and biological activities of seven Asphodeline taxa: potential sources of natural-functional ingredients for bioactive formulations.
abstract: The current study was carried out to evaluate multicomponent pattern, biological and enzymatic activities of seven Asphodeline taxa root extracts as useful ingredients, due to the fact that these plants are commonly used as traditional food supplements in Turkish regions. The extracts were characterized for free anthraquinones and phenolics to obtain a specific chemical fingerprint useful for quality control. These analyzes were coupled to biological and enzymatic activities in order to obtain comprehensive information of the natural product. Free anthraquinones and phenolics were determined using validated HPLC-PDA methods. Antioxidant properties were determined by different procedures including free radical scavenging, reducing power, phosphomolybdenum and metal chelating assays. Ames assay was performed to evaluate mutagenic/antimutagenic properties. Enzyme inhibitory activities were tested against cholinesterase, tyrosinase, α-amylase and α-glucosidase. From the herein reported results, Asphodeline could be valuable for the production of bioactive products or food supplements for cosmetic and pharmaceutical industries.
authors: a Department of Pharmacy , University "G. d'Annunzio" of Chieti-Pescara , Chieti , Italy.|b Interuniversity Consortium of Structural and Systems Biology , Rome , Italy.
authors: Marcello
authors: M
authors: Locatelli
authors: c Science Faculty, Department of Biology , Selcuk University , Konya , Turkey.
authors: Gokhan
authors: G
authors: Zengin
authors: d Deparment of Medicinal Laboratory, Vocational School of Health Services , Selcuk University , Turkey.
authors: Ahmet
authors: A
authors: Uysal
authors: a Department of Pharmacy , University "G. d'Annunzio" of Chieti-Pescara , Chieti , Italy.
authors: Simone
authors: S
authors: Carradori
authors: a Department of Pharmacy , University "G. d'Annunzio" of Chieti-Pescara , Chieti , Italy.
authors: Elisa
authors: E
authors: De Luca
authors: a Department of Pharmacy , University "G. d'Annunzio" of Chieti-Pescara , Chieti , Italy.
authors: Giuseppe
authors: G
authors: Bellagamba
authors: c Science Faculty, Department of Biology , Selcuk University , Konya , Turkey.
authors: Abdurrahman
authors: A
authors: Aktumsek
authors: e Department of Chemistry, Faculty of Pharmacy , Medical University of Sofia , Bulgaria.
authors: Irina
authors: I
authors: Lazarova
mesh_terms: D000070381:Asparagales / Q000737:chemistry* / Q000145:classification; D002851:Chromatography, High Pressure Liquid; D000516:alpha-Amylases / Q000037:antagonists & inhibitors
chemical_list: D000516:alpha-Amylases
keywords: Asphodeline; anthraquinones; biological activity and bioactive compounds; multicomponent pattern; phenolics