title: Pediatric intracranial clear cell meningioma: a clinicopathological study of seven cases and literature review.
abstract: BACKGROUND
  In this study, we reported seven cases of pediatric intracranial clear cell meningiomas (CCMs) in our institution and reviewed the relevant literature to investigate the clinicopathological characteristics, treatment options, and prognosis of these rare tumors.
  
  
  METHODS
  From January 2005 to June 2016, we retrospectively reviewed seven pediatric intracranial CCMs in terms of their clinical data, preoperative MRI features, and prognosis. Moreover, a critical review of the English language literature was also conducted.
  
  
  RESULTS
  The patients consisted of two males and five females with a median age of 10.5 years (range 6-15 years) at initial surgery. Petroclival and cerebellopontine angle area was the most common location site (5/7). Accordingly, the most common initial manifestation was hearing loss (3/7), and the mean interval from onset of symptoms to admission was 6.8 months (1.5-24 months). Gross total resection was achieved in five patients. Of the six tumors with immunohistochemical records, MIB-1 labeling index varied from 3 to 20 % (mean 8.1 %). During the follow-up period (mean 76.9 months, range 16-180 months), four patients had experienced tumor recurrences and three patients died due to recurrences.
  
  
  CONCLUSIONS
  Pediatric intracranial CCMs have a tendency to recur. There is a significant relationship between MIB-1 labeling index and recurrence. Gross total resection is recommended; if not available, adjuvant radiotherapy should be used to reduce the recurrent rate. In addition, postoperative MRI follow-up should be monitored at an interval time after resection.
authors: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No. 6 Tiantan Xili, Beijing, 100050, China.|China National Clinical Research Center for Neurological Diseases, Beijing, 100050, China.
authors: Hao
authors: H
authors: Li
authors: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No. 6 Tiantan Xili, Beijing, 100050, China.|China National Clinical Research Center for Neurological Diseases, Beijing, 100050, China.
authors: Meng
authors: M
authors: Zhao
authors: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No. 6 Tiantan Xili, Beijing, 100050, China.|China National Clinical Research Center for Neurological Diseases, Beijing, 100050, China.
authors: Yuming
authors: Y
authors: Jiao
authors: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No. 6 Tiantan Xili, Beijing, 100050, China.|China National Clinical Research Center for Neurological Diseases, Beijing, 100050, China.
authors: Zhicen
authors: Z
authors: Li
authors: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No. 6 Tiantan Xili, Beijing, 100050, China.|China National Clinical Research Center for Neurological Diseases, Beijing, 100050, China.
authors: Ji
authors: J
authors: Ma
authors: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No. 6 Tiantan Xili, Beijing, 100050, China.|China National Clinical Research Center for Neurological Diseases, Beijing, 100050, China.
authors: Shuo
authors: S
authors: Wang
authors: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No. 6 Tiantan Xili, Beijing, 100050, China. caoyong6@hotmail.com.|China National Clinical Research Center for Neurological Diseases, Beijing, 100050, China. caoyong6@hotmail.com.
authors: Yong
authors: Y
authors: Cao
authors: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No. 6 Tiantan Xili, Beijing, 100050, China. zhaojz205@163.com.|China National Clinical Research Center for Neurological Diseases, Beijing, 100050, China. zhaojz205@163.com.
authors: Jizong
authors: J
authors: Zhao
mesh_terms: D000293:Adolescent; D002648:Child; D015331:Cohort Studies; D005260:Female; D006801:Humans; D019394:Ki-67 Antigen / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D008297:Male; D008577:Meningeal Neoplasms / Q000000981:diagnostic imaging* / Q000601:surgery*; D008579:Meningioma / Q000000981:diagnostic imaging* / Q000601:surgery*
chemical_list: D019394:Ki-67 Antigen
keywords: Clear cell meningioma; Clinicopathological features; Pediatric; Prognosis