title: Epizootiological study of rodent-borne hepatitis E virus HEV-C1 in small mammals in Hanoi, Vietnam.
abstract: There is concern about the zoonotic potential of rodent-borne hepatitis E virus, designated as HEV-C1. However, epizootiological information about HEV-C1 is limited. To address this issue, serum samples from 443 small mammals captured at 5 sites in Hanoi, Vietnam, were examined for anti-HEV-C1 IgG antibodies. In addition, livers of seropositive animals were examined for viral RNA. Anti-HEV-C1 antibodies were detected in 57 (12.9%) of the 443 serum samples. Seropositive animals were found in all of the sites (4.7% to 22.2%). Anti-HEV-C1 antibodies were detected from 48 (12.3%) of 389 Rattus norvegicus and 9 (19.6%) of 46 R. tanezumi, but were not detected from 8 Suncus murinus. Viral RNAs were detected from 13 (22.8%) of the 57 seropositive rodents. The detection rate of viral RNA in seropositive R. tanezumi (66.7%, 6/9) was significantly higher than that in seropositive R. norvegicus (14.6%, 7/48). The results suggest that R. tanezumi is more susceptible than R. norvegicus to HEV-C1 infection. Phylogenetic analysis revealed that Vietnamese strains were divided into 3 clusters in genetic group 2 of HEV-C1. Multiple clusters of viruses were detected at several sites without species specificity, suggesting that 3 clusters of HEV-C1 co-circulate in Hanoi, Vietnam.
authors: Department of Microbiology, Hokkaido University Graduate School of Medicine, Kita-15, Nishi-7, Kita-ku, Sapporo 060-8638, Japan.
authors: Satomu
authors: S
authors: Obana
authors: Kenta
authors: K
authors: Shimizu
authors: Kumiko
authors: K
authors: Yoshimatsu
authors: Futoshi
authors: F
authors: Hasebe
authors: Kozue
authors: K
authors: Hotta
authors: Rie
authors: R
authors: Isozumi
authors: Hoa Thuy
authors: HT
authors: Nguyen
authors: Mai Quynh
authors: MQ
authors: LE
authors: Tetsu
authors: T
authors: Yamashiro
authors: Yoshimi
authors: Y
authors: Tsuda
authors: Jiro
authors: J
authors: Arikawa
mesh_terms: D000818:Animals; D006508:Hepatitis Antibodies / Q000097:blood; D016751:Hepatitis E / Q000453:epidemiology / Q000662:veterinary*; D016752:Hepatitis E virus / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D007074:Immunoglobulin G / Q000097:blood; D010802:Phylogeny; D012367:RNA, Viral / Q000097:blood; D051381:Rats; D012376:Rodent Diseases / Q000453:epidemiology / Q000821:virology; D016036:Seroepidemiologic Studies; D014744:Vietnam / Q000453:epidemiology
chemical_list: D006508:Hepatitis Antibodies; D007074:Immunoglobulin G; D012367:RNA, Viral