title: Pan Drug-Resistant Environmental Isolate of Acinetobacter baumannii from Croatia.
abstract: Acinetobacter baumannii is an emerging nosocomial pathogen with also emerging resistance to different antibiotics. Multidrug and pan drug-resistant clinical isolates were reported worldwide. Here we report the first evidence of pan drug-resistant environmental isolate of A. baumannii. The isolate was recovered from the effluent of secondary treated municipal wastewater of the City of Zagreb, Croatia. The isolate was resistant to penicillins/β-lactamase inhibitors, carbapenems, fluoroquinolones, aminoglycosides, folate pathway inhibitors, and polymyxins, except intermediately susceptible to minocycline and tigecycline. Intrinsic chromosomally located blaOXA-51-likegene and acquired plasmid-located blaOXA-23-likegene were related to clinical isolates. Pan drug-resistant A. baumannii can occur in natural environments outside of the hospital. Secondary treated municipal wastewater represents a potential epidemiological reservoir of pan drug-resistant A. baumannii and carbapenem resistance gene.
authors: 1 Department of Clinical Microbiology, University of Split School of Medicine , Split, Croatia .|2 University Hospital Centre Split , Split, Croatia .
authors: Ivana
authors: I
authors: Goic-Barisic
authors: 3 Department of Biology, Faculty of Science, University of Zagreb , Zagreb, Croatia .
authors: Martina
authors: M
authors: Seruga Music
authors: 4 Institute of Public Health of Split and Dalmatia County , Split, Croatia .
authors: Ana
authors: A
authors: Kovacic
authors: 1 Department of Clinical Microbiology, University of Split School of Medicine , Split, Croatia .|2 University Hospital Centre Split , Split, Croatia .
authors: Marija
authors: M
authors: Tonkic
authors: 3 Department of Biology, Faculty of Science, University of Zagreb , Zagreb, Croatia .
authors: Jasna
authors: J
authors: Hrenovic
mesh_terms: D040981:Acinetobacter baumannii / Q000145:classification / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification*; D000617:Aminoglycosides / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000235:genetics*; D015780:Carbapenems / Q000494:pharmacology; D017523:Croatia; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics*; D024841:Fluoroquinolones / Q000494:pharmacology; D015870:Gene Expression; D006801:Humans; D008826:Microbial Sensitivity Tests; D008911:Minocycline / Q000031:analogs & derivatives / Q000494:pharmacology; D010802:Phylogeny; D010957:Plasmids / Q000737:chemistry / Q000378:metabolism; D011113:Polymyxins / Q000494:pharmacology; D000078304:Tigecycline; D062065:Wastewater / Q000382:microbiology*; D001618:beta-Lactamases / Q000235:genetics*
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D015780:Carbapenems; D024841:Fluoroquinolones; D008911:Minocycline; D011113:Polymyxins; D000078304:Tigecycline; D062065:Wastewater; D001618:beta-Lactamases; C000599728:beta-lactamase OXA-23, Acinetobacter baumannii; C577373:beta-lactamase OXA-51, Acinetobacter baumannii
keywords: Acinetobacter baumannii; antibiotics; microbial drug resistance; public health; wastewater