title: MTHFR rs1801133 polymorphism and susceptibility to colorectal cancer in Iranian population: evidence of a case-control study and meta-analysis.
abstract: Several studies have investigated whether MTHFR rs1801133 polymorphism contributes to risk of colorectal cancer (CRC), however the results are inconclusive.
  
  
  OBJECTIVE
  The purpose of this study was to investigate this hypothesis in a case-control study and meta-analysis in Iranian population.
  
  
  METHODS
  This polymorphism was genotyped in the 2421 subjects (46% CRC patients) from Tehran. Meta-analysis was performed for determining the risk effect size of this polymorphism on CRC.
  
  
  RESULTS
  Both case-control study and meta-analysis showed no association between rs1801133 and CRC risk or its features.
  
  
  CONCLUSIONS
  This study failed to identify an association between the rs1801133 and susceptibility to CRC in Iranian population.
authors: Bone and Joint Reconstruction Research Center, Shafa Yahyaeian Orthopedics Hospital, Iran University of Medical Sciences, Tehran, Iran.
authors: Monir Sadat
authors: MS
authors: Haerian
authors: Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors: Batoul Sadat
authors: BS
authors: Haerian
authors: Department of Pathology, Milad Hospital, Tehran, Iran.
authors: Saadat
authors: S
authors: Molanaei
authors: Department of Pathology, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.
authors: Farid
authors: F
authors: Kosari
authors: Department of Pathology, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors: Shahram
authors: S
authors: Sabeti
authors: Department of Pathology, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors: Farahnaz
authors: F
authors: Bidari-Zerehpoosh
authors: Department of Pathology, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors: Ebrahim
authors: E
authors: Abdolali
authors: Gastroenterology & Liver Diseases Research Center (GLDRC), Shahid Beheshti University of Medical Science, Tehran, Iran.
authors: Mohammad Reza
authors: MR
authors: Zali
keywords: MTHFR; colorectal cancer; meta-analysis; polymorphism; susceptibility