title: [Analysis of HPA gene Polymorphisms in Children with Acute or Chronic ITP].
abstract: OBJECTIVE
  To investigate the frequency distribution of human platelet antigen allele HPA-2 and HPA-15 among the pediatric patients with acute or chronic idiopathic thrombocytopenic purpura (ITP) in Chinese Guangxi area, and to explore the potential correlation of ITP with HPA-2 and HPA-15 gene polymorphisms.
  
  
  METHODS
  The clinical and laboratorial data of 46 children diagnosed as acute ITP and 46 children diagnosed as chronic ITP between January 2007 and December 2014 were collected. Genotyping of HPA-2 and HPA-15 in 92 ITP patients and 48 healthy controls was performed by using polymerase chain reaction (PCR) combined with direct sequencing.
  
  
  RESULTS
  The allele frequencies of HPA-2 and HPA-15 were significantly different among the acute, chronic and control groups; the allele frequencies were significantly different between the chronic ITP group and the control group (P<0.0167), while the difference was not statistically significant between the acute and chronic ITP groups as well as between the acute ITP and the control group (P>0.0167).
  
  
  CONCLUSIONS
  The gene polymorphism of HPA-2 and HPA-15 may correlate with the risk of chronic ITP, but may not correlate with acute ITP in children.
authors: Department of Pediatrics, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
authors: Li-Juan
authors: LJ
authors: Tang
authors: Department of Pediatrics, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
authors: Xiao-Heng
authors: XH
authors: Zhou
authors: Department of Pediatrics, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
authors: Qiong
authors: Q
authors: Bin
authors: Department of Pediatrics, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
authors: Xiao-Hua
authors: XH
authors: Huang
authors: Department of Pediatrics, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China. E-mail: jmluo@aliyun.com.
authors: Jiang-Ming
authors: JM
authors: Luo
mesh_terms: D000483:Alleles; D016824:Antigens, Human Platelet; D044466:Asian People; D002648:Child; D002681:China; D002908:Chronic Disease; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D016553:Purpura, Thrombocytopenic, Idiopathic
chemical_list: D016824:Antigens, Human Platelet