title: On Materials for Cardiac Tissue Engineering.
abstract: In this essay the authors argue that chamber pressure dominates the biomechanics of the contraction cycle of the heart, while tissue stiffness dominates the relaxation cycle. This appears to be an under-recognized challenge in cardiac tissue engineering. Optimal approaches will involve constructing chambers or modulating the stiffness of the scaffold/substrate in synchrony with the beating cycle.
authors: Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, 02114, USA.|Harvard Medical School, Boston, MA, 02115, USA.
authors: Ibrahim J
authors: IJ
authors: Domian
authors: Institute of Bioengineering and Nanotechnology, Singapore, 138669.|Singapore-MIT Alliance for Research and Technology, 1 CREATE Way, #10-01 CREATE Tower, Singapore, 138602.|Department of Physiology, Yong Loo Lin School of Medicine, National University Health System, Singapore, 117597.
authors: Hanry
authors: H
authors: Yu
authors: Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, 02114, USA.|Institute of Bioengineering and Nanotechnology, Singapore, 138669.
authors: Nikhil
authors: N
authors: Mittal
mesh_terms: D000818:Animals; D006801:Humans; D009206:Myocardium; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds
keywords: cardiac; chamber pressure; materials; stiffness; tissue engineering