title: Hierarchical self-assembly of heparin-PEG end-capped porous silica as a redox sensitive nanocarrier for doxorubicin delivery.
abstract: Porous nanosilica (PNS) has been attracting a great attention in fabrication carriers for drug delivery system (DDS). However, unmodified PNS-based carriers exhibited the initial burst release of loaded bioactive molecules, which may limit their potential clinical application. In this study, the surface of PNS was conjugated with adamantylamine (A) via disulfide bonds (PNS-SS-A) which was functionalized with cyclodextrin-heparin-polyethylene glycol (CD-HPEG) for redox triggered doxorubicin (DOX) delivery. The modified PNS was successfully formed with spherical shape and diameter around 50nm determined by transmission electron microscopy (TEM). DOX was efficiently trapped in the PNS-SS-A@CD-HPEG and slowly released in phosphate buffered saline (PBS) without any initial burst effect. Importantly, the release of DOX was triggered due to the cleavage of the disulfide bonds in the presence of dithiothreitol (DTT). In addition, the MTT assay data showed that PNS-SS-A@CD-HPEG was a biocompatible nanocarrier and reduced the toxicity of DOX. These results demonstrated that PNS-SS-A@CD-HPEG has great potential as a novel nanocarrier for anticancer drug in cancer therapy.
authors: Institute of Research and Development, Duy Tan University, Da Nang City 550000, Vietnam; Institute of Applied Materials Science, Vietnam Academy of Science and Technology, Ho Chi Minh City 70000, Vietnam.
authors: Thu Thao
authors: TT
authors: Nguyen Thi
authors: Institute of Research and Development, Duy Tan University, Da Nang City 550000, Vietnam; Institute of Applied Materials Science, Vietnam Academy of Science and Technology, Ho Chi Minh City 70000, Vietnam.
authors: Tuong Vi
authors: TV
authors: Tran
authors: Institute of Research and Development, Duy Tan University, Da Nang City 550000, Vietnam; Institute of Applied Materials Science, Vietnam Academy of Science and Technology, Ho Chi Minh City 70000, Vietnam.
authors: Ngoc Quyen
authors: NQ
authors: Tran
authors: Institute of Applied Materials Science, Vietnam Academy of Science and Technology, Ho Chi Minh City 70000, Vietnam.
authors: Cuu Khoa
authors: CK
authors: Nguyen
authors: Institute of Applied Materials Science, Vietnam Academy of Science and Technology, Ho Chi Minh City 70000, Vietnam. Electronic address: nguyendaihai0511@gmail.com.
authors: Dai Hai
authors: DH
authors: Nguyen
mesh_terms: D016923:Cell Death; D004317:Doxorubicin / Q000494:pharmacology*; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D065546:Drug Liberation; D006367:HeLa Cells; D006493:Heparin / Q000138:chemical synthesis / Q000737:chemistry*; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010084:Oxidation-Reduction; D011092:Polyethylene Glycols / Q000138:chemical synthesis / Q000737:chemistry*; D066244:Proton Magnetic Resonance Spectroscopy; D012822:Silicon Dioxide / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013696:Temperature; D014961:X-Ray Diffraction
chemical_list: D004337:Drug Carriers; D011092:Polyethylene Glycols; D012822:Silicon Dioxide; D004317:Doxorubicin; D006493:Heparin
keywords: Cyclodextrin; Disulfide bond; Doxorubicin; Heparin; Host-guest complex; Polyethylene glycol; Porous nanosilica; Redox sensitive; Self-assembly