title: Gold-Nanorods-Based Gene Carriers with the Capability of Photoacoustic Imaging and Photothermal Therapy.
abstract: Multifunctional nanoparticles with high gene transfection activity, low cytotoxicity, photoacoustic imaging ability, and photothermal therapeutic properties were prepared by conjugating low-molecular-weight polyethylenimine onto the surfaces of gold nanorods through the formation of stable S-Au bonded conjugates. Results revealed that the gene transfection efficiency of the prepared polyethylenimine-modified gold nanorods (GNRs-PEI1.8k) was higher and their cytotoxicity was less than those of the commercial reagent PEI25k. GNRs-PEI1.8k could also be potentially used as a photoacoustic and photothermal reagent to evaluate the pharmacokinetics, biodistribution, and antitumor effects of gene/drug nanoparticles. Therefore, GNRs-PEI1.8k can be considered a promising candidate for the clinical diagnosis and treatment of tumors.
authors: Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , Changchun 130022, China.
authors: Jie
authors: J
authors: Chen
authors: Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , Changchun 130022, China.|Department of Chemistry, Northeast Normal University , Changchun 130024, China.
authors: Hong
authors: H
authors: Liang
authors: Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , Changchun 130022, China.
authors: Lin
authors: L
authors: Lin
authors: Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , Changchun 130022, China.|State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau , Macao 999078, China.
authors: Zhaopei
authors: Z
authors: Guo
authors: Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , Changchun 130022, China.
authors: Pingjie
authors: P
authors: Sun
authors: State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau , Macao 999078, China.
authors: Meiwan
authors: M
authors: Chen
authors: Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , Changchun 130022, China.
authors: Huayu
authors: H
authors: Tian
authors: Department of Chemistry, Northeast Normal University , Changchun 130024, China.
authors: Mingxiao
authors: M
authors: Deng
authors: Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , Changchun 130022, China.
authors: Xuesi
authors: X
authors: Chen
mesh_terms: D006046:Gold; D043942:Nanotubes; D061088:Photoacoustic Techniques; D010789:Phototherapy; D014018:Tissue Distribution
chemical_list: D006046:Gold
keywords: gene therapy; gold nanorods; multifunctional nanoparticles; photoacoustic imaging; photothermal therapy