title: Ultrasound lineal measurements predict ventricular volume in posthaemorrhagic ventricular dilatation in preterm infants.
abstract: OBJECTIVE
  Posthaemorrhagic ventricular dilatation (PHVD) is monitored by conventional two-dimensional ultrasound (2DUS). The aims of this study were to determine the volume of the lateral ventricles using three-dimensional ultrasound (3DUS) in preterm infants with PHVD and to evaluate the relationship between volume and linear measurements.
  
  
  METHODS
  Serial 2DUSs and 3DUSs were performed on preterm infants with PHVD admitted to the neonatal intensive care unit at Puerta del Mar Hospital, Cádiz, Spain, from January 2013 to December 2014. The ventricular index, anterior horn width and thalamo-occipital distance were used as ventricular lineal measurements. Ventricular volume was calculated offline.
  
  
  RESULTS
  Serial ultrasounds from seven preterm infants were measured. Each linear measurement was significantly associated with volume, and an equation was obtained through a significant multilevel mixed-effects lineal regression model: ventricular volume (cm3) = -11.02 + 0.668*VI + 0.817*AHW + 0.256*TOD. Intra-observer and interobserver agreement was excellent with an intraclass correlation coefficient of 0.99.
  
  
  CONCLUSIONS
  Lateral ventricular volumes of preterm infants with PHVD could be reliably determined using 3DUS. Ventricular volume could be accurately estimated using three lineal measurements. More studies are needed to address the importance of volume determination in PHVD.
authors: Neonatology Department, "Puerta del Mar" University Hospital, Cadiz, Spain.|Fundación Nene (Neonatal Neurology Research Group), Madrid, Spain.
authors: Isabel
authors: I
authors: Benavente-Fernandez
authors: Faculty of Medicine, University of Cádiz, Cádiz, Spain.
authors: Manuel
authors: M
authors: Lubián-Gutierrez
authors: Research Unit, "Puerta del Mar" University Hospital, Cadiz, Spain.
authors: Gema
authors: G
authors: Jimenez-Gomez
authors: Research Unit, "Puerta del Mar" University Hospital, Cadiz, Spain.
authors: Alfonso M
authors: AM
authors: Lechuga-Sancho
authors: Neonatology Department, "Puerta del Mar" University Hospital, Cadiz, Spain.|Fundación Nene (Neonatal Neurology Research Group), Madrid, Spain.
authors: Simon P
authors: SP
authors: Lubián-López
mesh_terms: D002552:Cerebral Ventricles / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D021621:Imaging, Three-Dimensional; D007231:Infant, Newborn; D007234:Infant, Premature; D019102:Infant, Very Low Birth Weight; D020300:Intracranial Hemorrhages / Q000000981:diagnostic imaging* / Q000473:pathology; D016014:Linear Models; D009929:Organ Size; D014463:Ultrasonography / Q000379:methods*
keywords: Cranial ultrasound; Posthaemorrhagic ventricular dilatation; Preterm infant; Three-dimensional ultrasound; Ventricular volume