title: Association of Physical Activity and Inflammation With All-Cause, Cardiovascular-Related, and Cancer-Related Mortality.
abstract: OBJECTIVE
  To investigate the association between physical activity (PA) and risk of mortality in a large middle-aged cohort stratified by inflammatory status.
  
  
  METHODS
  A total of 336,560 individuals (mean age, 39.7 years; 58% male) who underwent comprehensive health screenings were enrolled in this prospective cohort study. They were grouped according to self-reported PA level using a questionnaire: no regular PA with a sedentary lifestyle, regular but insufficient PA (below the guidelines), sufficient PA (concordant with the guidelines), and health-enhancing PA. Inflammation was assessed via high-sensitivity C-reactive protein (hsCRP) level. Study end points were all-cause, cardiovascular-related, and cancer-related mortality.
  
  
  RESULTS
  During the 1,976,882 person-years of follow-up (median follow-up duration, 6.17 years), 2062 deaths occurred. Compared with a sedentary lifestyle, the hazard ratios (95% CIs) on the multivariable Cox proportional hazards regression analyses for all-cause mortality by PA level were 0.95 (0.84-1.07), 0.85 (0.72-0.99), and 0.75 (0.60-0.93) (P for trend=.003), and those for cardiovascular- and cancer-related mortality were 0.95, 0.80, and 0.55 (P for trend=.05) and 0.82, 0.83, and 0.78 (P for trend=.01), respectively. Compared with participants with low hsCRP levels and any regular PA, those with high hsCRP levels and no regular PA had a significantly higher risk of mortality (1.59 [1.38-1.84]).
  
  
  CONCLUSIONS
  Higher PA levels were associated with a dose-dependent reduced risk of cardiovascular-related, cancer-related, and all-cause mortality. Individuals with high hsCRP levels and no regular PA had the highest risk of mortality.
authors: Division of Cardiology, Department of Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine, Seoul, Republic of Korea.
authors: Jong-Young
authors: JY
authors: Lee
authors: Department of Occupational and Environmental Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine, Seoul, Republic of Korea.
authors: Seungho
authors: S
authors: Ryu
authors: Division of Cardiology, Department of Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine, Seoul, Republic of Korea.
authors: EunSun
authors: E
authors: Cheong
authors: Division of Cardiology, Department of Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine, Seoul, Republic of Korea. Electronic address: kcmd.sung@samsung.com.
authors: Ki-Chul
authors: KC
authors: Sung
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D001943:Breast Neoplasms / Q000378:metabolism; D002097:C-Reactive Protein / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000378:metabolism / Q000401:mortality*; D015984:Causality; D015331:Cohort Studies; D015897:Comorbidity; D015444:Exercise / Q000502:physiology*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000453:epidemiology* / Q000378:metabolism; D018836:Inflammation Mediators / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009043:Motor Activity / Q000502:physiology; D009369:Neoplasms / Q000378:metabolism / Q000401:mortality*; D011446:Prospective Studies; D018570:Risk Assessment; D014481:United States / Q000453:epidemiology
chemical_list: D015415:Biomarkers; D018836:Inflammation Mediators; D002097:C-Reactive Protein