title: Impact of adherence to antiemetic guidelines on the incidence of chemotherapy-induced nausea and vomiting and quality of life.
abstract: Background International guidelines are tools enabling physicians to incorporate the latest evidence based clinical information into practice. Objective This study aimed to evaluate the impact of antiemetic guidelines adherence on the incidence of chemotherapy-induced nausea and vomiting (CINV) and patient quality of life. Setting Marmara University Pendik Training and Research Hospital chemotherapy unit, Istanbul, Turkey. Method The study included 100 chemotherapy naive patients. Antiemetic prescribing patterns and their consistency with MASCC/ESMO 2014 guidelines were assessed. Patients recorded incidences of vomiting in a daily dairy and described their nausea using a 7-item Likert Scale. The incidence of CINV was recorded over five days. To assess the patient's quality of life, a modified Turkish version of the Functional Living Index-Emesis (FLIE) questionnaire was administered before and after receiving chemotherapy. A questionnaire on the existence and severity of side effects was developed and administered. Main outcome measures Incidence of side effects on CINV and quality of life according to the FLIE. Results The primary outcome revealed differences in complete control (no emetic episodes, rescue therapy or nausea), FLIE scores and side effects. Guidelines consistency was observed more with acute (A) than with delayed (D) prevention of CINV, with significant differences in complete control between the guideline adherent group (GAG) and the guideline nonadherent group (GNG). Significant differences in the FLIE score were noticed between GAG(D) and GNG(D), and GNG(D) had a higher incidence of diarrhoea, headache, swallowing difficulties and dark-coloured stool. Conclusion Consistency with guidelines resulted in significant reduction in the incidence of both cute and delayed CINV and other side effects, and with improvement of the patient quality of life.
authors: Department of Clinical Pharmacy, School of Pharmacy, Istanbul Kemerburgaz University, Istanbul, Turkey. nibal.abunuhlah@kemerburgaz.edu.tr.|Department of Clinical Pharmacy, School of Pharmacy, Marmara University, Istanbul, Turkey. nibal.abunuhlah@kemerburgaz.edu.tr.
authors: Nibal
authors: http://orcid.org/0000-0002-6990-1945
authors: N
authors: Abunahlah
authors: Department of Clinical Pharmacy, School of Pharmacy, Marmara University, Istanbul, Turkey.
authors: Mesut
authors: M
authors: Sancar
authors: Department of Internal Medicine, Division of Medical Oncology, School of Medicine, Marmara University, Istanbul, Turkey.
authors: Faysal
authors: F
authors: Dane
authors: Molecular Medicine Department, Division of Hospital Management, Marmara University Pendik Training and Research Hospital, Istanbul, Turkey.
authors: Mustafa Kerem
authors: MK
authors: Özyavuz
mesh_terms: D000932:Antiemetics / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000009:adverse effects*; D005260:Female; D019983:Guideline Adherence / Q000592:standards*; D006801:Humans; D015994:Incidence; D008297:Male; D055118:Medication Adherence; D008875:Middle Aged; D009325:Nausea / Q000139:chemically induced / Q000188:drug therapy*; D011446:Prospective Studies; D011788:Quality of Life; D014839:Vomiting / Q000139:chemically induced / Q000188:drug therapy*
chemical_list: D000932:Antiemetics; D000970:Antineoplastic Agents
keywords: Adverse drug reaction; Chemotherapy; Guideline; Nausea; Quality of life; Vomiting