title: Pure and multi metal oxide nanoparticles: synthesis, antibacterial and cytotoxic properties.
abstract: Th antibacterial activity of metal oxide nanoparticles has received marked global attention as they can be specifically synthesized to exhibit significant toxicity to bacteria. The importance of their application as antibacterial agents is evident keeping in mind the limited range and effectiveness of antibiotics, on one hand, and the plethora of metal oxides, on the other, along with the propensity of nanoparticles to induce resistance being much lower than that of antibiotics. Effective inhibition against a wide range of bacteria is well known for several nano oxides consisting of one metal (Fe3O4, TiO2, CuO, ZnO), whereas, research in the field of multi-metal oxides still demands extensive exploration. This is understandable given that the relationship between physicochemical properties and biological activity seems to be complex and difficult to generalize even for metal oxide nanoparticles consisting of only one metal component. Also, despite the broad scope that metal oxide nanoparticles have as antibacterial agents, there arise problems in practical applications taking into account the cytotoxic effects. In this respect, the consideration of polymetallic oxides for biological applications becomes even greater since these can provide synergetic effects and unify the best physicochemical properties of their components. For instance, strong antibacterial efficiency specific of one metal oxide can be complemented by non-cytotoxicity of another. This review presents the main methods and technological advances in fabrication of nanostructured metal oxides with a particular emphasis to multi-metal oxide nanoparticles, their antibacterial effects and cytotoxicity.
authors: CNRS, Institut des Nanosciences de Paris (INSP), UMR 7588, 4 Place Jussieu, 75252, Paris Cedex 05, France. slavica.stankic@insp.upmc.fr.|UPMC-Université Paris 06, INSP, UMR 7588, Paris, France. slavica.stankic@insp.upmc.fr.
authors: Slavica
authors: S
authors: Stankic
authors: Birla Institute of Technology & Science, Pilani Campus, Vidya Vihar, Pilani, Rajasthan, India.
authors: Sneha
authors: S
authors: Suman
authors: CNRS, Institut des Nanosciences de Paris (INSP), UMR 7588, 4 Place Jussieu, 75252, Paris Cedex 05, France.|UPMC-Université Paris 06, INSP, UMR 7588, Paris, France.
authors: Francia
authors: F
authors: Haque
authors: Virologie et Immunologie Moléculaires, UR892, INRA, Paris Saclay University, Jouy en Josas, France. jasmina.vidic@inra.fr.|School of Material Science and Engineering, Nanyang Technological University, 50 Nanyang Ave, Singapore, 639798, Singapore. jasmina.vidic@inra.fr.|NTU-HJU-BGU CREATE Programme, 1 Create Way, Research Wing # 02-06 to 08, Singapore, 138602, Singapore. jasmina.vidic@inra.fr.
authors: Jasmina
authors: J
authors: Vidic
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000633:toxicity; D001419:Bacteria / Q000187:drug effects; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry / Q000633:toxicity; D010087:Oxides / Q000737:chemistry / Q000633:toxicity
chemical_list: D000900:Anti-Bacterial Agents; D010087:Oxides
keywords: Antibacterial activity; Cytotoxicity; Multi-metal oxide nanoparticles; Nanoparticles synthesis