title: Aerosol Delivery of Curcumin Reduced Amyloid-β Deposition and Improved Cognitive Performance in a Transgenic Model of Alzheimer's Disease.
abstract: We report a novel approach for the delivery of curcumin to the brain via inhalation of the aerosol for the potential treatment of Alzheimer's disease. The percentage of plaque fraction in the subiculum and hippocampus reduced significantly when young 5XFAD mice were treated with inhalable curcumin over an extended period of time compared to age-matched nontreated counterparts. Further, treated animals demonstrated remarkably improved overall cognitive function, no registered systemic or pulmonary toxicity associated with inhalable curcumin observed during the course of this work.
authors: Institute of Imaging Science, Vanderbilt University, Nashville, TN, USA.|Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, USA.|Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA.
authors: Richard
authors: R
authors: McClure
authors: Institute of Imaging Science, Vanderbilt University, Nashville, TN, USA.|Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, USA.
authors: Henry
authors: H
authors: Ong
authors: Institute of Imaging Science, Vanderbilt University, Nashville, TN, USA.|Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, USA.
authors: Vaibhab
authors: V
authors: Janve
authors: Institute of Imaging Science, Vanderbilt University, Nashville, TN, USA.|Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, USA.
authors: Shawn
authors: S
authors: Barton
authors: Institute of Imaging Science, Vanderbilt University, Nashville, TN, USA.|Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, USA.
authors: Meiying
authors: M
authors: Zhu
authors: Institute of Imaging Science, Vanderbilt University, Nashville, TN, USA.|Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, USA.
authors: Bo
authors: B
authors: Li
authors: Vanderbilt Cell Imaging Core Laboratory, Nashville, TN, USA.
authors: Mary
authors: M
authors: Dawes
authors: Department of Pathology, Microbiology and Immunology, Vanderbilt University, Nashville, TN, USA.
authors: W Gray
authors: WG
authors: Jerome
authors: Institute of Imaging Science, Vanderbilt University, Nashville, TN, USA.|Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, USA.|Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA.
authors: Adam
authors: A
authors: Anderson
authors: Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, TN, USA.
authors: Pierre
authors: P
authors: Massion
authors: Institute of Imaging Science, Vanderbilt University, Nashville, TN, USA.|Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, USA.|Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA.|Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA.
authors: John C
authors: JC
authors: Gore
authors: Institute of Imaging Science, Vanderbilt University, Nashville, TN, USA.|Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, USA.|Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA.|Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, TN, USA.|Vanderbilt Institute of Chemical Biology, Nashville, TN, USA.|Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA.
authors: Wellington
authors: W
authors: Pham
mesh_terms: D000280:Administration, Inhalation; D000544:Alzheimer Disease / Q000150:complications* / Q000235:genetics; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D016564:Amyloid beta-Protein Precursor / Q000235:genetics; D000704:Analysis of Variance; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D003072:Cognition Disorders / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism; D003474:Curcumin / Q000008:administration & dosage*; D049229:Dendritic Spines / Q000187:drug effects / Q000473:pathology / Q000648:ultrastructure; D004195:Disease Models, Animal; D006624:Hippocampus / Q000187:drug effects / Q000473:pathology / Q000648:ultrastructure; D006801:Humans; D018782:Maze Learning / Q000187:drug effects; D008570:Memory, Short-Term / Q000187:drug effects; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D046529:Microscopy, Electron, Transmission; D009154:Mutation / Q000235:genetics; D009474:Neurons / Q000187:drug effects / Q000473:pathology / Q000648:ultrastructure; D053764:Presenilin-1 / Q000235:genetics
chemical_list: D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor; D000894:Anti-Inflammatory Agents, Non-Steroidal; D053764:Presenilin-1; D003474:Curcumin
keywords: Aerosol; amyloid-β; curcumin; nebulization