title: Turning Failure into Success: Trials of the Heart Failure Clinical Research Network.
abstract: The Heart Failure Clinical Research Network (HFN) was established in 2008 on behalf of the NIH National Heart, Lung and Blood Institute, with the primary goal of improving outcomes in heart failure (HF) by designing and conducting high-quality concurrent clinical trials testing interventions across the spectrum of HF. Completed HFN trials have answered several important and relevant clinical questions concerning the safety and efficacy of different decongestive and adjunctive vasodilator therapies in hospitalized acute HF, phosphodiesterase-5 inhibition and nitrate therapies in HF with preserved ejection fraction, and the role of xanthine oxidase inhibition in hyperuricemic HF. These successes, independent of the "positive" or "negative" result of each individual trial, have helped to shape the current clinical care of HF patients and serve as a platform to inform future research directions and trial designs.
authors: Section of Heart Failure and Cardiac Transplant Medicine, Sydell and Arnold Miller Family Heart and Vascular Institute, Cleveland Clinic Foundation, Cleveland, OH, USA. emerjoyce@yahoo.co.uk.
authors: Emer
authors: E
authors: Joyce
authors: Cardiovascular Division, Brigham and Women's Hospital, Boston, MA, USA.
authors: Michael M
authors: MM
authors: Givertz
mesh_terms: D004232:Diuretics / Q000494:pharmacology; D004311:Double-Blind Method; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006333:Heart Failure / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D009566:Nitrates / Q000494:pharmacology; D058986:Phosphodiesterase 5 Inhibitors / Q000494:pharmacology; D016032:Randomized Controlled Trials as Topic; D057170:Translational Research, Biomedical; D016896:Treatment Outcome; D014481:United States; D014665:Vasodilator Agents / Q000494:pharmacology; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors
chemical_list: D004232:Diuretics; D004791:Enzyme Inhibitors; D009566:Nitrates; D058986:Phosphodiesterase 5 Inhibitors; D014665:Vasodilator Agents; D014969:Xanthine Oxidase
keywords: Clinical research; Clinical trials; Heart failure