title: A Clinical Perspective: Contribution of Dysfunctional Perivascular Adipose Tissue (PVAT) to Cardiovascular Risk.
abstract: Perivascular adipose tissue (PVAT) is now recognized as an important paracrine organ influencing the homeostasis of the vessel wall, regional blood flow and peripheral arterial resistance. There is remarkable phenotypic variability and plasticity of PVAT among various vascular beds, exhibiting phenotypes from white to brown and beige adipocytes. PVAT dysfunction is characterized by disturbed secretion of various adipokines, which, together with endothelial dysfunction, contribute to hypertension and cardiovascular disease (CVD). This brief review describes our current knowledge on PVAT in health and cardiovascular disease, with a special focus on different phenotypes and signaling pathways in adipocytes of PVAT associated with hypertension, obesity and cardiovascular disorders.
authors: Experimental and Clinical Research Center (ECRC) - a joint cooperation between the Charité-University Medicine Berlin and the Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125, Berlin, Germany.
authors: Xiaoming
authors: X
authors: Lian
authors: Experimental and Clinical Research Center (ECRC) - a joint cooperation between the Charité-University Medicine Berlin and the Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125, Berlin, Germany. maik.gollasch@charite.de.|Medical Clinic for Nephrology and Internal Intensive Care, Charité Campus Virchow Klinikum, Augustenburger Platz 1, 13353, Berlin, Germany. maik.gollasch@charite.de.
authors: Maik
authors: M
authors: Gollasch
mesh_terms: D017667:Adipocytes / Q000378:metabolism; D054392:Adipokines / Q000378:metabolism; D000273:Adipose Tissue / Q000502:physiology; D000818:Animals; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D009765:Obesity / Q000503:physiopathology; D012307:Risk Factors
chemical_list: D054392:Adipokines
keywords: KCNQ-type KV7 channels; Perivascular relaxing factors, PVRFs; adipocyte-derived relaxing factor, ADRF; adiponectin; beige adipocytes; hydrogen sulfide, H2S