title: Bifunctional RuII-Complex-Catalysed Tandem C-C Bond Formation: Efficient and Atom Economical Strategy for the Utilisation of Alcohols as Alkylating Agents.
abstract: Catalytic activities of a series of functional bipyridine-based RuIIcomplexes in β-alkylation of secondary alcohols using primary alcohols were investigated. Bifunctional RuIIcomplex (3 a) bearing 6,6'-dihydroxy-2,2'-bipyridine (6DHBP) ligand exhibited the highest catalytic activity for this reaction. Using significantly lower catalyst loading (0.1 mol %) dehydrogenative carbon-carbon bond formation between numerous aromatic, aliphatic and heteroatom substituted alcohols were achieved with high selectivity. Notably, for the synthesis of β-alkylated secondary alcohols this protocol is a rare one-pot strategy using a metal-ligand cooperative RuIIsystem. Remarkably, complex 3 a demonstrated the highest reactivity compared to all the reported transition metal complexes in this reaction.
authors: Department of Chemistry, IIT Kanpur, Kanpur, 208016, UP, India.
authors: Bivas Chandra
authors: BC
authors: Roy
authors: Department of Chemistry, IIT Kanpur, Kanpur, 208016, UP, India.
authors: Kaushik
authors: K
authors: Chakrabarti
authors: Department of Chemistry, IIT Kanpur, Kanpur, 208016, UP, India.
authors: Sujan
authors: S
authors: Shee
authors: Department of Chemistry, IIT Kanpur, Kanpur, 208016, UP, India.
authors: Subhadeep
authors: S
authors: Paul
authors: Department of Chemistry, IIT Kanpur, Kanpur, 208016, UP, India.
authors: Sabuj
authors: http://orcid.org/0000-0002-4227-294X
authors: S
authors: Kundu
keywords: C−C bond formation; atom economical; bifunctional catalysis; catalysis; ruthenium