title: Histological evaluation of follicular delivery of arginine via nanostructured lipid carriers: a novel potential approach for the treatment of alopecia.
abstract: The use of lipidic nanoparticles can overcome the limitations of skin penetration of hydrophilic charged materials. Oleic acid as an ion pairing agent was used to enhance the encapsulation of positively charged arginine into lipophilic nanostructured lipid carrier (NLC). Histological study on the male hamsters was performed to assess the efficiency of drug delivery on hair growth. The accumulation of NLCs in the hair follicles was verified and in vivo studies showed more new hair follicle growth by utilizing arginine-loaded NLCs than arginine aqueous solution. It was concluded that employing ion pairing agent could enhance drug encapsulation into NLCs structure.
authors: a Biotechnology Research Center and Students' Research Committee, Faculty of Pharmacy , Tabriz University of Medical Sciences , Tabriz , Iran.
authors: Seyedeh Narjes
authors: SN
authors: Yazdani-Arazi
authors: b Department of Pharmaceutics, Faculty of Pharmacy , Zanjan University of Medical Sciences , Zanjan , Iran.
authors: Saeed
authors: S
authors: Ghanbarzadeh
authors: c Dermatology & Dermopharmacy Research Team, Faculty of Pharmacy , Tabriz University of Medical Sciences , Tabriz , Iran.
authors: Khosro
authors: K
authors: Adibkia
authors: d Research Center for Pharmaceutical Nanotechnology and Department of Oral and Maxillofacial Pathology, Faculty of Dentistry , Tabriz University of Medical Sciences , Tabriz , Iran.
authors: Maryam
authors: M
authors: Kouhsoltani
authors: e Drug Applied Research Center , Tabriz University of Medical Sciences , Tabriz , Iran.
authors: Hamed
authors: H
authors: Hamishehkar
mesh_terms: D000505:Alopecia / Q000188:drug therapy*; D000818:Animals; D001120:Arginine / Q000737:chemistry* / Q000378:metabolism / Q000627:therapeutic use*; D006224:Cricetinae; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D018859:Hair Follicle / Q000378:metabolism*; D008055:Lipids / Q000737:chemistry*; D008297:Male; D049329:Nanostructures / Q000737:chemistry*; D010316:Particle Size
chemical_list: D004337:Drug Carriers; D008055:Lipids; D001120:Arginine
keywords: Arginine; NLC; alopecia; dermal drug delivery; nanostructured lipid carriers