title: Association between thecatechol-o-methyltransferaseval158met polymorphism with susceptibility and severity of carpal tunnel syndrome.
abstract: Carpal tunnel syndrome (CTS) is the most common entrapment neuropathy of the upper extremity. In this study, we aimed to clarify the relationships between thecatechol-O-methyltransferase(COMT) geneVal158Met(rs4680) polymorphism and development, functional and clinical status of CTS. Ninety-five women with electro diagnostically confirmed CTS and 95 healthy controls were enrolled in the study. The functional and clinical status of the patients was measured by the Turkish version of the Boston Questionnaire and intensity of pain related to the past 2 weeks was evaluated on a visual analog scale (VAS). TheVal158Metpolymorphism was determined using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), method. We divided patients according to the genotypes of theVal158Metpolymorphism as Val/Val, Val/Met and Met/Met. There were not any significant differences in terms ofVal158Metpolymorphisms between patients and healthy controls (p>0.05). We also did not find any relationships between theVal158Metpolymorphism and CTS (p>0.05). In conclusion, although we did not find any relationships between CTS and theVal158Metpolymorphism, we could not generalize this result to the general population. Future studies are warranted to conclude precise associations.
authors: Department of Physical Medicine and Rehabilitation, Süleyman Demirel University, Faculty of Medicine, Çünür, Isparta, Turkey.
authors: E
authors: E
authors: Erkol İnal
authors: Department of Physical Medicine and Rehabilitation, Ankara Occupational Disease Hospital, Ankara, Turkey.
authors: P
authors: P
authors: Eroğlu
authors: Department of Medical Genetics, Bursa Şevket Yılmaz Education and Research Hospital, Bursa, Turkey.
authors: O
authors: O
authors: Görükmez
authors: Department of Medical Genetics, Uludağ University, Faculty of Medicine, Bursa, Turkey.
authors: Ş
authors: Ş
authors: Özemri Sağ
authors: Department of Medical Genetics, Uludağ University, Faculty of Medicine, Bursa, Turkey.
authors: T
authors: T
authors: Yakut
keywords: Boston questionnaire; Carpal tunnel syndrome (CTS); Val158Met (rs4680) polymorphism; catechol-O-methyltransferase (COMT) gene; pain