title: The Two Alternative Rate-Determining Steps in Benzylic Lithiation Reactions of Esters and Carbamates.
abstract: Lithiation reactions of tertiary benzylic esters and carbamates have been studied. Kinetic methodology revealed that a two-step reaction pathway should be considered for these reactions, where either the lithium precomplexation and/or the proton transfer steps can be rate determining. Kinetic isotopic effects were evaluated by comparison of the lithiations of the corresponding protio/deutero substrates, and the results obtained support the notion that lithium precomplexation is taking place on the reaction pathway and that it is the rate-determining step in this transformation.
authors: Departamento de Química Orgánica and Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CIQUS), Universidade de Santiago de Compostela , 15782 Santiago de Compostela, Spain.
authors: Fernando
authors: F
authors: Fernández-Nieto
authors: Departamento de Química Orgánica and Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CIQUS), Universidade de Santiago de Compostela , 15782 Santiago de Compostela, Spain.
authors: M Rita
authors: MR
authors: Paleo
authors: Departamento de Química Orgánica and Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CIQUS), Universidade de Santiago de Compostela , 15782 Santiago de Compostela, Spain.
authors: Roberto
authors: R
authors: Colunga
authors: Departamento de Química Física and Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CIQUS), Universidade de Santiago de Compostela , 15782 Santiago de Compostela, Spain.
authors: M Luz
authors: ML
authors: Raposo
authors: Departamento de Química Física and Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CIQUS), Universidade de Santiago de Compostela , 15782 Santiago de Compostela, Spain.
authors: Luis
authors: L
authors: Garcia-Rio
authors: Departamento de Química Orgánica and Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CIQUS), Universidade de Santiago de Compostela , 15782 Santiago de Compostela, Spain.
authors: F Javier
authors: FJ
authors: Sardina