title: Application of Ru(II)-Catalyzed Enyne Cyclization in the Synthesis of Brefeldin A.
abstract: The approach to brefeldin A described herein hinges on Ru(II)-catalyzed cycloisomerization of an enyne obtained by the reaction of an alkynylzinc reagent with an α-chloro sulfide. Other key steps include Mislow-Evans rearrangement, cross-metathesis, and macrocyclization using a Roush-Masamune protocol.
authors: Natural Product Chemistry Division, Indian Institute of Chemical Technology , Hyderabad, India.|Academy of Scientific and Innovative Research, Indian Institute of Chemical Technology , Hyderabad, India.
authors: Sadagopan
authors: S
authors: Raghavan
authors: Natural Product Chemistry Division, Indian Institute of Chemical Technology , Hyderabad, India.|Academy of Scientific and Innovative Research, Indian Institute of Chemical Technology , Hyderabad, India.
authors: Mahesh Kumar Rao
authors: MK
authors: Yelleni
mesh_terms: D020126:Brefeldin A / Q000138:chemical synthesis*; D066241:Carbon-13 Magnetic Resonance Spectroscopy; D002384:Catalysis; D003500:Cyclization; D006838:Hydrocarbons / Q000737:chemistry*; D007202:Indicators and Reagents / Q000737:chemistry; D066244:Proton Magnetic Resonance Spectroscopy; D012428:Ruthenium / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D013440:Sulfides / Q000737:chemistry; D017967:Zinc Compounds / Q000737:chemistry
chemical_list: D006838:Hydrocarbons; D007202:Indicators and Reagents; D013440:Sulfides; D017967:Zinc Compounds; D020126:Brefeldin A; D012428:Ruthenium