title: Evodiamine and Its Role in Chronic Diseases.
abstract: Evodiamine (EVO) is a major alkaloid compound extracted from the dry unripened fruit Evodiae fructus (Evodia rutaecarpa Benth., Rutaceae). EVO has a variety of pharmacological activities, such as anti-obesity, anti-allergenic, analgesic, anti-tumor, anti-ulcerogenic, and neuroprotective activities. EVO has varying efficacies in animal models and humans. Here, the physicochemical properties of EVO are presented, and the EVO's functions and mechanisms of action in various chronic diseases are reviewed. EVO is worth exploring in more depth in the future for its potential use in various chronic diseases.
authors: Department of Thoracic Surgery, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, 400042, China. tanqy001@163.com.
authors: Qunyou
authors: Q
authors: Tan
authors: Chongqing Research Center for Pharmaceutical Engineering, Chongqing Medical University, Chongqing, 400016, China. zjqrae01@163.com.
authors: Jingqing
authors: J
authors: Zhang
mesh_terms: D000700:Analgesics / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D000818:Animals; D018926:Anti-Allergic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D019440:Anti-Obesity Agents / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D002908:Chronic Disease / Q000188:drug therapy*; D004195:Disease Models, Animal; D032086:Evodia / Q000737:chemistry*; D006801:Humans; D015394:Molecular Structure; D008517:Phytotherapy; D010946:Plants, Medicinal; D011799:Quinazolines / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D015398:Signal Transduction / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D000700:Analgesics; D018926:Anti-Allergic Agents; D000890:Anti-Infective Agents; D000893:Anti-Inflammatory Agents; D019440:Anti-Obesity Agents; D000972:Antineoplastic Agents, Phytogenic; D011799:Quinazolines; C049639:evodiamine
keywords: Cell signaling pathways; Chronic diseases; Evodiamine; Mechanisms of action; Pharmacological activities; Physico-chemical properties