title: Increased circulating anti-α6-integrin autoantibodies in psoriasis and psoriatic arthritis but not in rheumatoid arthritis.
abstract: In psoriatic skin, laminin integrity is altered, which could lead to insufficient laminin integrin interactions, leaving the α6-integrin exposed and possibly accessible for autoantibody production. Therefore we investigated the presence of anti-α6-integrin autoantibodies in the serum of patients with psoriasis vulgaris (Ps), psoriatic arthritis (PsA) and rheumatoid arthritis (RA) in comparison with healthy donors. The level of circulating anti-α6-integrin antibodies was determined by enzyme-linked immunoassay using α6-integrin fragments. Antibodies against at least one recombinant fragment were found in approximately 30% of Ps and PsA patients. In contrast, in RA patients, the frequency of antibodies was similar to healthy controls. Our study shows the presence of anti-α6-integrin antibodies in Ps and PsA but not in RA, which could indicate ongoing abnormal processes in the skin. Anti-α6-integrin autoantibodies may contribute to the formation of micro-wounds in the skin and to the characteristic wound-healing phenotype in psoriasis.
authors: Department of Dermatology and Allergology, University of Szeged, Szeged, Hungary.
authors: Brigitta
authors: B
authors: Gál
authors: Department of Rheumatology, University of Szeged, Szeged, Hungary.
authors: Sonja
authors: S
authors: Dulic
authors: Department of Dermatology and Allergology, University of Szeged, Szeged, Hungary.
authors: Mária
authors: M
authors: Kiss
authors: MTA-SZTE, Dermatological Research Group, Szeged, Hungary.
authors: Gergely
authors: G
authors: Groma
authors: Department of Rheumatology, University of Szeged, Szeged, Hungary.
authors: László
authors: L
authors: Kovács
authors: Department of Dermatology and Allergology, University of Szeged, Szeged, Hungary.|MTA-SZTE, Dermatological Research Group, Szeged, Hungary.
authors: Lajos
authors: L
authors: Kemény
authors: Department of Dermatology and Allergology, University of Szeged, Szeged, Hungary.
authors: Zsuzsanna
authors: Z
authors: Bata-Csörgő
mesh_terms: D000328:Adult; D015535:Arthritis, Psoriatic / Q000097:blood / Q000276:immunology*; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000276:immunology*; D001323:Autoantibodies / Q000097:blood / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D039503:Integrin alpha6 / Q000276:immunology* / Q000378:metabolism; D007797:Laminin / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000097:blood / Q000276:immunology*; D012867:Skin / Q000276:immunology; D014945:Wound Healing / Q000276:immunology
chemical_list: D001323:Autoantibodies; D039503:Integrin alpha6; D007797:Laminin
keywords: alpha-6-integrin; antibodies; psoriasis; psoriatic arthritis; rheumatoid arthritis