title: Controlling cell adhesion using layer-by-layer approaches for biomedical applications.
abstract: Controlling the adhesion of mammalian and bacterial cells at the interfaces between synthetic materials and biological environments is a real challenge in the biomedical fields such as tissue engineering, antibacterial coating, implantable biomaterials and biosensors. The surface properties of materials are known to profoundly influence the adhesion processes. To mediate the adhesion processes, polymeric coatings have been used to functionalize surfaces to introduce diverse physicochemical properties. The polyelectrolyte multilayer films built via the layer-by-layer (LbL) method, introduced by Moehwald, Decher, and Lvov 20years ago, has led to significant developments ranging from the fundamental understanding of cellular processes to controlling cell adhesion for biomedical applications. In this review, we focus our attention on the modification of surface physicochemical properties, using the LbL approach, to construct films which can either promote or inhibit mammalian/bacterial cell adhesion. We also discuss the emerging field of multifunctional surfaces capable of responding to specific cellular activity but being inert to the others.
authors: NUS Graduate School for Integrative Science and Engineering, National University of Singapore, Kent Ridge, Singapore 117576, Singapore.
authors: Shanshan
authors: S
authors: Guo
authors: Institute of Materials Research and Engineering (IMRE), A*STAR (Agency for Science, Technology and Research, 2 Fusionopolis Way, Singapore, 138634, Singapore. Electronic address: zhux@imre.a-star.edu.sg.
authors: Xiaoying
authors: X
authors: Zhu
authors: Institute of Materials Research and Engineering (IMRE), A*STAR (Agency for Science, Technology and Research, 2 Fusionopolis Way, Singapore, 138634, Singapore; Department of Materials Science and Engineering, National University of Singapore, Singapore, Singapore; Singapore Eye Research Institute, Singapore, Singapore. Electronic address: lohxj@imre.a-star.edu.sg.
authors: Xian Jun
authors: XJ
authors: Loh
mesh_terms: D000818:Animals; D001422:Bacterial Adhesion; D020811:Biomedical Technology / Q000379:methods*; D002448:Cell Adhesion; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D013499:Surface Properties
keywords: Biomedical application; Cell adhesion; LbL assembly; Mammalian and bacterial cells; Surface modification