title: Estimating individual optimal sleep duration and potential sleep debt.
abstract: In this study, we hypothesized that dynamics of sleep time obtained over consecutive days of extended sleep in a laboratory reflect an individual's optimal sleep duration (OSD) and that the difference between OSD and habitual sleep duration (HSD) at home represents potential sleep debt (PSD). We found that OSD varies among individuals and PSD showed stronger correlation with subjective/objective sleepiness than actual sleep time, interacting with individual's vulnerability of sleep loss. Furthermore, only 1 h of PSD takes four days to recover to their optimal level. Recovery from PSD was also associated with the improvement in glycometabolism, thyrotropic activity and hypothalamic-pituitary-adrenocortical axis. Additionally, the increase (rebound) in total sleep time from HSD at the first extended sleep would be a simple indicator of PSD. These findings confirmed self-evaluating the degree of sleep debt at home as a useful clinical marker. To establish appropriate sleep habits, it is necessary to evaluate OSD, vulnerability to sleep loss, and sleep homeostasis characteristics on an individual basis.
authors: Department of Psychophysiology, National Institute of Mental Health, National Center of Neurology and Psychiatry, 4-1-1, Ogawa-Higashi, Kodaira, Tokyo, 187-8553, Japan.
authors: Shingo
authors: S
authors: Kitamura
authors: Department of Psychophysiology, National Institute of Mental Health, National Center of Neurology and Psychiatry, 4-1-1, Ogawa-Higashi, Kodaira, Tokyo, 187-8553, Japan.
authors: Yasuko
authors: Y
authors: Katayose
authors: Department of Psychophysiology, National Institute of Mental Health, National Center of Neurology and Psychiatry, 4-1-1, Ogawa-Higashi, Kodaira, Tokyo, 187-8553, Japan.
authors: Kyoko
authors: K
authors: Nakazaki
authors: Department of Psychophysiology, National Institute of Mental Health, National Center of Neurology and Psychiatry, 4-1-1, Ogawa-Higashi, Kodaira, Tokyo, 187-8553, Japan.
authors: Yuki
authors: Y
authors: Motomura
authors: Department of Psychophysiology, National Institute of Mental Health, National Center of Neurology and Psychiatry, 4-1-1, Ogawa-Higashi, Kodaira, Tokyo, 187-8553, Japan.
authors: Kentaro
authors: K
authors: Oba
authors: Department of Psychophysiology, National Institute of Mental Health, National Center of Neurology and Psychiatry, 4-1-1, Ogawa-Higashi, Kodaira, Tokyo, 187-8553, Japan.
authors: Ruri
authors: R
authors: Katsunuma
authors: Department of Psychophysiology, National Institute of Mental Health, National Center of Neurology and Psychiatry, 4-1-1, Ogawa-Higashi, Kodaira, Tokyo, 187-8553, Japan.
authors: Yuri
authors: Y
authors: Terasawa
authors: Department of Psychophysiology, National Institute of Mental Health, National Center of Neurology and Psychiatry, 4-1-1, Ogawa-Higashi, Kodaira, Tokyo, 187-8553, Japan.
authors: Minori
authors: M
authors: Enomoto
authors: Department of Psychophysiology, National Institute of Mental Health, National Center of Neurology and Psychiatry, 4-1-1, Ogawa-Higashi, Kodaira, Tokyo, 187-8553, Japan.
authors: Yoshiya
authors: Y
authors: Moriguchi
authors: Department of Psychophysiology, National Institute of Mental Health, National Center of Neurology and Psychiatry, 4-1-1, Ogawa-Higashi, Kodaira, Tokyo, 187-8553, Japan.
authors: Akiko
authors: A
authors: Hida
authors: Department of Psychophysiology, National Institute of Mental Health, National Center of Neurology and Psychiatry, 4-1-1, Ogawa-Higashi, Kodaira, Tokyo, 187-8553, Japan.
authors: Kazuo
authors: K
authors: Mishima
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D001786:Blood Glucose / Q000032:analysis / Q000378:metabolism; D006801:Humans; D008297:Male; D009490:Neurosecretory Systems / Q000502:physiology; D017286:Polysomnography; D012890:Sleep / Q000502:physiology*; D013972:Thyrotropin / Q000097:blood; D013997:Time Factors; D014851:Wakefulness
chemical_list: D001786:Blood Glucose; D000324:Adrenocorticotropic Hormone; D013972:Thyrotropin