title: Virus-host interactions under hypoxia.
abstract: Oxygen tension can exert a significant effect on viral propagation in vitro and possibly in vivo. In general, hypoxia restricts the replication of viruses that naturally infect tissues exposed to ambient oxygen and induces the growth of viruses that naturally target tissues exposed to low oxygen. Some viruses can reprogram cell bioenergetics towards lowering cellular respiration and therefore oxygen consumption in order to support their replication. Aim of this review is to summarize findings on the interplay between viral infection and oxygen levels, highlighting the implicated oxygen tension-sensitive elements and metabolic determinants and concluding with possible therapeutic approaches targeting these mediators.
authors: Molecular Virology Laboratory, Hellenic Pasteur Institute, 127 Vas. Sofias Av., 11521, Athens, Greece. Electronic address: nikiv@pasteur.gr.
authors: Niki
authors: N
authors: Vassilaki
authors: Molecular Virology Laboratory, Hellenic Pasteur Institute, 127 Vas. Sofias Av., 11521, Athens, Greece.
authors: Efseveia
authors: E
authors: Frakolaki
mesh_terms: D054884:Host-Pathogen Interactions; D000860:Hypoxia / Q000473:pathology*; D014777:Virus Diseases / Q000473:pathology* / Q000821:virology*; D014779:Virus Replication; D014780:Viruses / Q000472:pathogenicity*
keywords: Bioenergetics; Hypoxia; Hypoxia inducible factor; Metabolism; Viruses