title: Human Immunodeficiency Virus in Kidney Transplantation.
abstract: Patients infected with human immunodeficiency virus (HIV) are living longer, healthier lives on highly active antiretroviral therapy and, as a result, interest in kidney transplantation for HIV-infected patients with end-stage renal disease has increased. HIV is no longer considered a contraindication to solid-organ transplantation and the number of kidney transplants performed in HIV-infected patients each year is increasing steadily. HIV-infected kidney transplant recipients have had excellent outcomes overall, but there are still significant challenges, including high rates of acute rejection, drug-drug interactions, and poor outcomes in patients co-infected with hepatitis C virus. The gap between supply and demand for organs remains a challenge but new developments in HIV-positive to HIV-positive kidney transplantation may help bridge this gap.
authors: Division of Infectious Diseases, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
authors: Kathleen O
authors: KO
authors: Degnan
authors: Division of Infectious Diseases, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA. Electronic address: blumbere@mail.med.upenn.edu.
authors: Emily A
authors: EA
authors: Blumberg
mesh_terms: D019380:Anti-HIV Agents / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active; D060085:Coinfection; D004347:Drug Interactions; D006084:Graft Rejection / Q000517:prevention & control*; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy*; D019698:Hepatitis C, Chronic / Q000150:complications; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007676:Kidney Failure, Chronic / Q000150:complications / Q000601:surgery*; D016030:Kidney Transplantation; D016896:Treatment Outcome
chemical_list: D019380:Anti-HIV Agents; D007166:Immunosuppressive Agents
keywords: HIV-infected deceased donors (HIVDD); Human immunodeficiency virus (HIV); drug interactions; highly active antiretroviral therapy (HAART); kidney transplant