title: Factors predicting the outcome following surgical treatment of mesial temporal epilepsy due to mesial temporal sclerosis.
abstract: Mesial temporal sclerosis (MTS) is the most common disease found in an epilepsy surgery series. Early age of onset, a history of febrile convulsions, epileptiform discharges on EEG, duration of epilepsy, number of generalized seizures and severity of psychiatric disorders are possible prognostic factors in patients with MTS.
  
  
  
  The aim of this study is to review the clinical, semiotic, psychological, electrophysiological and neuroradiological researches and relate their findings to the prognosis of patients with MTS who underwent anteromedial temporal lobectomy (ATL).
  
  
  
  Of 1,214 patients evaluated for surgery in the epilepsy Center of Faculdade de Medicina de São Jose do Rio Preto (FAMERP), a tertiary Brazilian epilepsy center, 400 underwent ATL for MTS. Examinations and clinical data were analyzed and compared with the Engel Outcome Classification.
  
  
  
  Of all the items analyzed, the MRI showed the greatest influence on patient outcome. As for the clinical evaluation and pathological antecedents, age at surgery, epilepsy duration, perinatal insults, family history of epilepsy, febrile seizures, neuropsychological abnormalities and presence of generalized tonic-clonic seizure all had statistical significance.
  
  
  
  In order to identify the most appropriate candidates for ATL, it is very important to consider the prognostic factors associated with a favorable outcome for counseling patients in daily practice.
authors: Neurosurgery. Department of Neurological Sciences, Hospital de Base de São José do Rio Preto-Faculty of Medicine at São José do Rio Preto, São José do Rio Preto, São Paulo, Brazil. rodrigoadry@yahoo.fr.|Hospital Aliança, Salvador, Bahia, Brazil. rodrigoadry@yahoo.fr.
authors: Rodrigo Antonio Rocha da Cruz
authors: RA
authors: Adry
authors: Neurosurgery. Department of Neurological Sciences, Hospital de Base de São José do Rio Preto-Faculty of Medicine at São José do Rio Preto, São José do Rio Preto, São Paulo, Brazil.
authors: Lucas Crociati
authors: LC
authors: Meguins
authors: Neurosurgery. Department of Neurological Sciences, Hospital de Base de São José do Rio Preto-Faculty of Medicine at São José do Rio Preto, São José do Rio Preto, São Paulo, Brazil.
authors: Sebastião Carlos
authors: SC
authors: da Silva Júnior
authors: Federal University of Sergipe at Aracaju, Aracaju, Sergipe, Brazil.
authors: Carlos Umberto
authors: CU
authors: Pereira
authors: Psychiatry. Department of Neurological Sciences, Hospital de Base de São José do Rio Preto-Faculty of Medicine at São José do Rio Preto, São José do Rio Preto, São Paulo, Brazil.
authors: Gerardo Maria
authors: GM
authors: de Araújo Filho
authors: Neurology. Department of Neurological Sciences, Hospital de Base de São José do Rio Preto-Faculty of Medicine at São José do Rio Preto, São José do Rio Preto, São Paulo, Brazil.
authors: Lúcia Helena Neves
authors: LH
authors: Marques
mesh_terms: D000328:Adult; D038481:Anterior Temporal Lobectomy / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D004833:Epilepsy, Temporal Lobe / Q000000981:diagnostic imaging / Q000209:etiology / Q000601:surgery*; D005260:Female; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000000981:diagnostic imaging* / Q000453:epidemiology; D012598:Sclerosis / Q000150:complications; D016896:Treatment Outcome
keywords: Epilepsy; Mesial temporal sclerosis; Neurosurgery; Prognostic factors