title: Landscape of warfarin and clopidogrel pharmacogenetic variants in Qatari population from whole exome datasets.
abstract: OBJECTIVE
  Pharmacogenetic landscapes of commonly used antiplatelet drugs, warfarin and clopidogrel have been studied in-depth in many countries. However, there is a paucity of data to understand their patterns in the Arab populations.
  
  
  METHODS
  We analyzed the whole exome sequencing datasets of 100 Qatar individuals available in public domain with this perspective.
  
  
  RESULTS
  We characterized the allelic distribution of variants routinely tested for warfarin and clopidogrel. We additionally evaluated the population stratification and its effect on allele frequency distribution. Our analysis points to ethnic differences in the frequency distribution even for the small population studied.
  
  
  CONCLUSIONS
  This is one of the first and most comprehensive pharmacogenetic maps of variants associated with warfarin and clopidogrel for an Arab population, which can help tailor the drug dosage to the population.
authors: GN Ramachandran Knowledge Center for Genome Informatics, CSIR Institute of Genomics & Integrative Biology, Mathura Road, New Delhi 110025, India.|Academy of Scientific & Innovative Research (AcSIR), New Delhi 110025, India.
authors: Ambily
authors: A
authors: Sivadas
authors: Center for Computational Biology, Indraprastha Institute of Information Technology Delhi (IIIT-Delhi), Okhla Industrial Estate, Phase III, New Delhi 110020, India.
authors: Parul
authors: P
authors: Sharma
authors: GN Ramachandran Knowledge Center for Genome Informatics, CSIR Institute of Genomics & Integrative Biology, Mathura Road, New Delhi 110025, India.|Academy of Scientific & Innovative Research (AcSIR), New Delhi 110025, India.|Center for Computational Biology, Indraprastha Institute of Information Technology Delhi (IIIT-Delhi), Okhla Industrial Estate, Phase III, New Delhi 110020, India.
authors: Vinod
authors: V
authors: Scaria
keywords: Arab; Qatar; clopidogrel; pharmacogenetics; warfarin; whole exome