title: Rifampicin-Induced Concomitant Renal Injury and Hepatitis.
abstract: Adverse drug reactions are not unusual during Anti-Tubercular Therapy (ATT). One of the common complications of anti-tubercular treatment is drug induced hepatitis and renal insufficiency has also been reported. Renal failure and/or hepatitis encountered during treatment of tuberculosis can have varied aetiologies: drug induced, concomitant viral infection, pre-existing co-morbidities or a combination of these. Since, hepatitis and/or renal insufficiency can be life threatening a prompt diagnosis is warranted, where drugs should be kept as one of the important cause. Identifying the drug helps in treating hepatitis and/or renal insufficiency along with helping the physician to change the combination of ATT regimen. Rifampicin is one of the most important first line drugs in the treatment of tuberculosis. Hepatitis, epigastric distress, anaemia, thrombocytopenia, and interstitial nephritis are reported adverse drug reactions to rifampicin. As per literature rifampicin induced renal toxicity is usually seen on rifampicin re-exposure, or rifampicin administration on alternate days, both being present in this case. Here we are reporting a case of ATT induced renal failure with concomitant hepatitis where rifampicin was suspected to be the cause.
authors: Associate Professor, Department of Pharmacology, Kasturba Medical College, Manipal University , Manipal, Karnataka, India .
authors: Bharti
authors: B
authors: Chogtu
authors: Postgraduate Student, Department of Pulmonary Medicine, Kasturba Medical College, Manipal University , Manipal, Karnataka, India .
authors: Vyshak Uddur
authors: VU
authors: Surendra
authors: Professor, Department of Pulmonary Medicine, Kasturba Medical College, Manipal University , Manipal, Karnataka, India .
authors: Rahul
authors: R
authors: Magazine
authors: Associate Professor, Department of Pulmonary Medicine, Kasturba Medical College, Mangalore, Manipal University , Karnataka, India .
authors: Preetam Rajgopal
authors: PR
authors: Acharya
authors: Student, Kasturba Medical College, Manipal University , Manipal, Karnataka, India .
authors: Devesh Bhaskar
authors: DB
authors: Yerrapragada
keywords: Anti tubercular drugs; Liver function tests; Serum creatinine; Serum urea