title: A posterior probability approach for gene regulatory network inference in genetic perturbation data.
abstract: Inferring gene regulatory networks is an important problem in systems biology. However, these networks can be hard to infer from experimental data because of the inherent variability in biological data as well as the large number of genes involved. We propose a fast, simple method for inferring regulatory relationships between genes from knockdown experiments in the NIH LINCS dataset by calculating posterior probabilities, incorporating prior information. We show that the method is able to find previously identified edges from TRANSFAC and JASPAR and discuss the merits and limitations of this approach.
authors: University of Washington, Department of Statistics, Box 354322, Seattle, WA 98195-4322, United States. email: wmchad@uw.edu.
authors: William Chad
authors: WC
authors: Young
authors: Adrian E
authors: AE
authors: Raftery
authors: Ka Yee
authors: KY
authors: Yeung
mesh_terms: D000465:Algorithms; D053263:Gene Regulatory Networks; D008954:Models, Biological; D011336:Probability; D049490:Systems Biology / Q000379:methods*