title: Concentrations of Polychlorinated Biphenyls and Organochlorine Pesticides in Umbilical Cord Blood Serum of Newborns in Kingston, Jamaica.
abstract: To date much of the biomonitoring related to exposure to polychlorinated biphenyls (PCBs) and organochlorine (OC) pesticides is from middle to high income countries, including the U.S., Canada and Europe, but such data are lacking for the majority of low to middle income countries. Using data from 64 pregnant mothers who were enrolled in 2011, we aimed to assess the concentrations of the aforementioned toxins in umbilical cord blood serum of 67 Jamaican newborns. For 97 of the 100 PCB congeners and 16 of the 17 OC pesticides, all (100%) concentrations were below their respective limits of detection (LOD). Mean (standard deviation (SD)) lipid-adjusted concentrations in cord blood serum for congeners PCB-153, PCB-180, PCB-206 and total PCB were 14.25 (3.21), 7.16 (1.71), 7.30 (1.74) and 28.15 (6.03) ng/g-lipid, respectively. The means (SD) for the 4,4'-dichlorodiphenyldichloroethylene (DDE)-hexane fraction and total-DDE were 61.61 (70.78) and 61.60 (70.76) ng/g-lipid, respectively. Compared to the U.S. and Canada, the concentrations of these toxins were lower in cord-blood serum of Jamaican newborns. We discuss that these differences could be partly due to differences in dietary patterns in these countries. Despite limitations in our dataset, our results provide information on the investigated toxins in cord blood serum that could serve as a reference for Jamaican newborns.
authors: Division of Epidemiology, Human Genetics, and Environmental Sciences (EHGES), University of Texas School of Public Health at Houston, Houston, TX 77030, USA. Mohammad.H.Rahbar@uth.tmc.edu.|Division of Clinical and Translational Sciences, Department of Internal Medicine, University of Texas McGovern Medical School at Houston, Houston, TX 77030, USA. Mohammad.H.Rahbar@uth.tmc.edu.|Biostatistics/Epidemiology/Research Design (BERD) Component, Center for Clinical and Translational Sciences (CCTS), University of Texas Health Science Center at Houston, Houston, TX 77030, USA. Mohammad.H.Rahbar@uth.tmc.edu.
authors: Mohammad H
authors: MH
authors: Rahbar
authors: Department of Child & Adolescent Health, The University of the West Indies (UWI), Mona Campus, Kingston 7, Jamaica. msammsvaughan@gmail.com.
authors: Maureen
authors: M
authors: Samms-Vaughan
authors: Biostatistics/Epidemiology/Research Design (BERD) Component, Center for Clinical and Translational Sciences (CCTS), University of Texas Health Science Center at Houston, Houston, TX 77030, USA. Manouchehr.Hessabi@uth.tmc.edu.
authors: Manouchehr
authors: M
authors: Hessabi
authors: Biostatistics/Epidemiology/Research Design (BERD) Component, Center for Clinical and Translational Sciences (CCTS), University of Texas Health Science Center at Houston, Houston, TX 77030, USA. adickerson@hsph.harvard.edu.
authors: Aisha S
authors: AS
authors: Dickerson
authors: Division of Clinical and Translational Sciences, Department of Internal Medicine, University of Texas McGovern Medical School at Houston, Houston, TX 77030, USA. MinJae.Lee@uth.tmc.edu.|Biostatistics/Epidemiology/Research Design (BERD) Component, Center for Clinical and Translational Sciences (CCTS), University of Texas Health Science Center at Houston, Houston, TX 77030, USA. MinJae.Lee@uth.tmc.edu.
authors: MinJae
authors: M
authors: Lee
authors: Division of Epidemiology, Human Genetics, and Environmental Sciences (EHGES), University of Texas School of Public Health at Houston, Houston, TX 77030, USA. Jan.Bressler@uth.tmc.edu.|Human Genetics Center, University of Texas School of Public Health at Houston, Houston, TX 77030, USA. Jan.Bressler@uth.tmc.edu.
authors: Jan
authors: J
authors: Bressler
authors: Division of Chemistry and Toxicology, Michigan Department of Health and Human Services (MDHHS), Lansing, MI 48906, USA. sara.tomechko@gmail.com.
authors: Sara E
authors: SE
authors: Tomechko
authors: Division of Chemistry and Toxicology, Michigan Department of Health and Human Services (MDHHS), Lansing, MI 48906, USA. MorenoE@michigan.gov.
authors: Emily K
authors: EK
authors: Moreno
authors: Department of Psychiatry and Behavioral Sciences, University of Texas McGovern Medical School at Houston, Houston, TX 77054, USA. Katherine.A.Loveland@uth.tmc.edu.
authors: Katherine A
authors: KA
authors: Loveland
authors: Department of Child & Adolescent Health, The University of the West Indies (UWI), Mona Campus, Kingston 7, Jamaica. cooredesai@googlemail.com.
authors: Charlene Coore
authors: CC
authors: Desai
authors: Department of Child & Adolescent Health, The University of the West Indies (UWI), Mona Campus, Kingston 7, Jamaica. sydonniesp@gmail.com.
authors: Sydonnie
authors: S
authors: Shakespeare-Pellington
authors: Department of Child & Adolescent Health, The University of the West Indies (UWI), Mona Campus, Kingston 7, Jamaica. jodyreece@yahoo.com.
authors: Jody-Ann
authors: JA
authors: Reece
authors: Department of Child & Adolescent Health, The University of the West Indies (UWI), Mona Campus, Kingston 7, Jamaica. renee.n.morgan@gmail.com.
authors: Renee
authors: R
authors: Morgan
authors: Division of Chemistry and Toxicology, Michigan Department of Health and Human Services (MDHHS), Lansing, MI 48906, USA. geigerm@michigan.gov.
authors: Matthew J
authors: MJ
authors: Geiger
authors: Division of Chemistry and Toxicology, Michigan Department of Health and Human Services (MDHHS), Lansing, MI 48906, USA. okeefem@michigan.gov.
authors: Michael E
authors: ME
authors: O'Keefe
authors: Human Genetics Center, University of Texas School of Public Health at Houston, Houston, TX 77030, USA. Megan.L.Grove@uth.tmc.edu.
authors: Megan L
authors: ML
authors: Grove
authors: Division of Epidemiology, Human Genetics, and Environmental Sciences (EHGES), University of Texas School of Public Health at Houston, Houston, TX 77030, USA. Eric.Boerwinkle@uth.tmc.edu.|Human Genetics Center, University of Texas School of Public Health at Houston, Houston, TX 77030, USA. Eric.Boerwinkle@uth.tmc.edu.
authors: Eric
authors: E
authors: Boerwinkle
mesh_terms: D000328:Adult; D004784:Environmental Monitoring; D004785:Environmental Pollutants / Q000097:blood*; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D006801:Humans; D007231:Infant, Newborn; D007563:Jamaica; D057230:Limit of Detection; D008297:Male; D010575:Pesticides / Q000097:blood*; D011078:Polychlorinated Biphenyls / Q000097:blood*; D011247:Pregnancy
chemical_list: D004785:Environmental Pollutants; D010575:Pesticides; D011078:Polychlorinated Biphenyls; C014024:2,4,5,2',4',5'-hexachlorobiphenyl
keywords: Jamaica; Kingston; newborns; organochlorine (OC) pesticides; polychlorinated biphenyls (PCBs)