title: Hemorheological factors can be informative in comparing treatment possibilities of abdominal compartment syndrome.
abstract: BACKGROUND
  Abdominal compartment syndrome (ACS) is a life-threatening condition, of which pathomechanism hasn't been completely clarified, yet. Furthermore, surgical therapy still needs optimization.
  
  
  OBJECTIVE
  We aimed to investigate microcirculatory and micro-rheological alterations in ACS, using various temporary abdominal closure methods, including three settings of vacuum-assisted closure technique (negative pressure wound therapy, NPWT).
  
  
  METHODS
  On anesthetized pigs, by intraabdominally placed and filled-up silicone bags, intraabdominal pressure at 30 mmHg was maintained for 3 hours, and afterwards, decompressive laparotomy happened. In different experimental groups Bogota-bag or Vivano abdominal sets were applied (-50, -100, -150 mmHg) for 2 hours. Pressure monitoring was done by implanted sensors, hemorheological parameters were determined, and laser Doppler flowmetry tests were performed on the surface of intraabdominal organs.
  
  
  RESULTS
  Treatment with Bogota-bag and -150 mmHg vacuum increased erythrocyte aggregation, while deformability declined. Blood viscosity increased after treatment with -150 mmHg vacuum. The microcirculatory parameters of the NPWT groups were better in small intestine.
  
  
  CONCLUSIONS
  ACS resulted in impairment of macro- and micro-rheological parameters and abdominal organs' microcirculation. All of the used techniques improved the results, however, applying Bogota-bag or -150 mmHg vacuum set showed worse microcirculatory and micro-rheological data than the settings at -100 or -50 mmHg.
authors: Department of Operative Techniques & Surgical Research, Faculty of Medicine, University of Debrecen, Hungary.
authors: Norbert
authors: N
authors: Nemeth
authors: Department of Operative Techniques & Surgical Research, Faculty of Medicine, University of Debrecen, Hungary.
authors: Katalin
authors: K
authors: Peto
authors: Department of Operative Techniques & Surgical Research, Faculty of Medicine, University of Debrecen, Hungary.
authors: Adam
authors: A
authors: Deak
authors: Department of Operative Techniques & Surgical Research, Faculty of Medicine, University of Debrecen, Hungary.
authors: Viktoria
authors: V
authors: Sogor
authors: Department of Operative Techniques & Surgical Research, Faculty of Medicine, University of Debrecen, Hungary.
authors: Gabor
authors: G
authors: Varga
authors: Department of Operative Techniques & Surgical Research, Faculty of Medicine, University of Debrecen, Hungary.
authors: Bence
authors: B
authors: Tanczos
authors: Institute of Surgery, Faculty of Medicine, University of Debrecen, Hungary.
authors: Klaudia
authors: K
authors: Balog
authors: Institute of Surgery, Faculty of Medicine, University of Debrecen, Hungary.
authors: Adrienn
authors: A
authors: Csiszko
authors: Department of Information Technology, Faculty of Informatics, University of Debrecen, Hungary.
authors: Zoltan
authors: Z
authors: Godo
authors: Institute of Surgery, Faculty of Medicine, University of Debrecen, Hungary.
authors: Zsolt
authors: Z
authors: Szentkereszty
mesh_terms: D000005:Abdomen / Q000473:pathology*; D000818:Animals; D003161:Compartment Syndromes / Q000601:surgery*; D019299:Decompression, Surgical; D005260:Female; D059325:Intra-Abdominal Hypertension / Q000601:surgery*; D012212:Rheology; D013552:Swine
keywords: Abdominal compartment syndrome; hemorheology; microcirculation; negative pressure wound therapy