title: Development of the cardiac pacemaker.
abstract: The sinoatrial node (SAN) is the dominant pacemaker of the heart. Abnormalities in SAN formation and function can cause sinus arrhythmia, including sick sinus syndrome and sudden death. A better understanding of genes and signaling pathways that regulate SAN development and function is essential to develop more effective treatment to sinus arrhythmia, including biological pacemakers. In this review, we briefly summarize the key processes of SAN morphogenesis during development, and focus on the transcriptional network that drives SAN development.
authors: Key Laboratory of Arrhythmia, Shanghai East Hospital, Ministry of Education, Tongji University School of Medicine, 150 Jimo Road, Shanghai, 200120, China.
authors: Xingqun
authors: X
authors: Liang
authors: Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, 9500 Gilman Dr. M/C 0613C, BSB 5027, La Jolla, CA, 92093, USA.|Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.|Department of Pharmacology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.
authors: Sylvia M
authors: SM
authors: Evans
authors: Key Laboratory of Arrhythmia, Shanghai East Hospital, Ministry of Education, Tongji University School of Medicine, 150 Jimo Road, Shanghai, 200120, China. yfsun@tongji.edu.cn.
authors: Yunfu
authors: 0000-0003-2587-6220
authors: Y
authors: Sun
mesh_terms: D001146:Arrhythmia, Sinus / Q000209:etiology / Q000378:metabolism; D006331:Heart Diseases / Q000628:therapy*; D018398:Homeodomain Proteins / Q000378:metabolism; D006801:Humans; D060850:LIM-Homeodomain Proteins / Q000378:metabolism; D010138:Pacemaker, Artificial / Q000009:adverse effects; D012849:Sinoatrial Node / Q000378:metabolism; D020825:T-Box Domain Proteins / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism
chemical_list: D018398:Homeodomain Proteins; D060850:LIM-Homeodomain Proteins; D020825:T-Box Domain Proteins; D014157:Transcription Factors
keywords: Cardiac progenitors; Heart field; Pacemaker; Sinus node development; Sinus node dysfunction; Transcriptional regulation