title: [Effect of low-dose focused ultrasound pre-irradiation versus microbubbles for enhancing high-intensity focused ultrasound ablation of VX2hepatic tumor in rabbits].
abstract: OBJECTIVE
  To compare the effect of low-dose focused ultrasound pre-irradiation and microbubbles for enhancing the ablation effect of high intensity focused ultrasound (HIFU) on VX2hepatic tumor in rabbits.
  
  
  METHODS
  Fifty-five rabbits bearing VX2hepatic tumor were randomly divided into low-dose pre-irradiation + HIFU ablation group, microbubbles+HIFU ablation group, and HIFU ablation group for corresponding treatments. The pathological changes in the tumors after low-dose irradiation, time for HIFU ablation, tumor volume with coagulative necrosis, energy efficiency factor (EEF), pathological changes in the ablated tumor, and sound channel of HIFU ablation were observed.
  
  
  RESULTS
  Tumor cell edema, vacuolar changes in the cytoplasm and tumor interstitial vascular congestion were observed 24 h after low-dose pre-irradiation. The ablation time were significantly shorter, coagulative necrosis volume was larger, and EEF was lower in low-dose irradiation + HIFU ablation group and microbubbles+HIFU ablation group than in simple HIFU ablation group (P<0.05), but the differences between the former two groups were not significant. The effectiveness and stability of the synergistic effect of low-dose pre-irradiation were inferior to microbubbles, but the former ensured a better safety of the sound channel.
  
  
  CONCLUSIONS
  Low-dose irradiation has comparable synergistic effect in HIFU with microbubbles with such advantages as non-invasiveness, high concentration and good safety, and can be a potentially new method to enhance the efficiency of HIFU.
authors: 1Department of Ultrasound, First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China; 3State Key Laboratory of Ultrasound Engineering in Medicine Co-Founded by Chongqing and Ministry of Science and Technology, College of Biomedical Engineering, Chongqing Medical University, Chongqing Key Laboratory of Biomedical Engineering, Chongqing 400016, China. E-mail: bluespirit007@163.com.
authors: Yi
authors: Y
authors: Zhang
authors: Chao
authors: C
authors: Yang
authors: Jian-Zhong
authors: JZ
authors: Zou
authors: Fei
authors: F
authors: Chen
authors: Xia
authors: X
authors: Ou
authors: Hai-Rong
authors: HR
authors: Zou
authors: Yan
authors: Y
authors: Wang
mesh_terms: D000818:Animals; D057086:High-Intensity Focused Ultrasound Ablation; D008113:Liver Neoplasms / Q000628:therapy*; D045423:Microbubbles; D009336:Necrosis; D011817:Rabbits; D047368:Tumor Burden