title: The Effect ofCumin cyminumL. Plus Lime Administration on Weight Loss and Metabolic Status in Overweight Subjects: A Randomized Double-Blind Placebo-Controlled Clinical Trial.
abstract: BACKGROUND
  Limited data are available regarding the effects of combined administration ofCumin cyminumL. and lime on weight loss and metabolic profiles among subjects with overweight subjects.
  
  
  OBJECTIVE
  The current study aimed to assess the effects of combined administration ofCumin cyminumL. and lime on weight loss and metabolic profiles among subjects with overweight.
  
  
  METHODS
  This randomized double-blind placebo-controlled clinical trial was conducted on 72 subjects with overweight, aged 18 - 50 years old. Participants were randomly divided into three groups: Group A received high-doseCumin cyminumL. and lime capsules (75 mg each, n = 24), group B low-doseCumin cyminumL. and lime capsules (25 mg each, n = 24) and group C placebos (n = 24) twice daily for eight weeks.
  
  
  RESULTS
  After eight weeks of intervention, compared with low-doseC. cyminumL. plus lime and placebo, taking high-doseC. cyminumL. plus lime resulted in significant weight loss (in the high-dose group: -2.1 ± 1.7 vs. in the low-dose group: -1.2 ± 1.5 and in the placebo group: + 0.2 ± 1.3 kg, respectively; P < 0.001) and body mass index (-0.8 ± 0.6 vs. -0.5 ± 0.5 and +0.1 ± 0.5 kg/m2, respectively; P < 0.001). In addition, administration of high-doseC. cyminumL. plus lime compared with low-doseC. cyminumL. plus lime and placebo, led to a significant reduction in fasting plasma glucose (FPG) (P < 0.001) and a significant rise in quantitative insulin sensitivity check index (QUICKI) (+ 0.02 ± 0.02 vs. + 0.01 ± 0.02 and 0.01 ± 0.01, respectively; P = 0.01). Moreover, a significant decrease in serum triglycerides (-14.1 ± 56.2 vs. +13.9 ± 36.8 and + 10.6 ± 25.1 mg/dL; respectively; P = 0.03), total-cholesterol (-18.4 ± 28.6 vs. +8.6 ± 28.5 and -1.0 ± 24.8 mg/dL; respectively; P = 0.004) and low density lipoproteins- (LDL)-cholesterol levels (-11.8 ± 20.7 vs. +6.5 ± 23.2 and -2.9 ± 20.4 mg/dL, respectively; P = 0.01) was observed following the consumption of high-doseC. cyminumL. plus lime compared with low-doseC. cyminumL. plus lime and placebo.
  
  
  CONCLUSIONS
  Results of the current study indicated that taking high-doseC. cyminumL. plus lime for eight weeks among subjects with overweight had beneficial effects on weight, BMI, FPG, QUICKI, triglycerides, total-cholesterol and LDL-cholesterol levels.
authors: Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, IR Iran.
authors: Mohsen
authors: M
authors: Taghizadeh
authors: Barij Medicinal Plants Research Center, Kashan, IR Iran.
authors: Mohammad Reza
authors: MR
authors: Memarzadeh
authors: Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, IR Iran.
authors: Fatemeh
authors: F
authors: Abedi
authors: Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, IR Iran.
authors: Nasrin
authors: N
authors: Sharifi
authors: Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IR Iran.
authors: Fatemeh
authors: F
authors: Karamali
authors: Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, IR Iran.
authors: Zohreh
authors: Z
authors: Fakhrieh Kashan
authors: Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, IR Iran.
authors: Zatollah
authors: Z
authors: Asemi
keywords: Cuminum cyminum L; Insulin Resistance; Lim; Overweight