title: Trends in Hospitalization and Mortality of Venous Thromboembolism in Hospitalized Patients With Colon Cancer and Their Outcomes: US Perspective.
abstract: Venous thromboembolism (VTE) is a major cause of morbidity and mortality in hospitalized patients with colon cancer. We assessed nationwide population-based trends in rates of hospitalization and mortality from VTE among patients with colon cancer to determine its impact.
  
  
  
  We queried the Nationwide Inpatient Sample (NIS) database entries from 2003 to 2011 to identify patients with colon cancer. Bivariate group comparisons between hospitalized patients with colon cancer with VTE to those without VTE were made. Multivariate logistic regression analysis was used to obtain adjusted odds ratios. The Cochrane-Armitage test for linear trend was used to assess occurrences of VTE and mortality rates among patients with colon cancer.
  
  
  
  The total number patients with colon cancer was 1,502,743, of which 41,394 (2.75%) had VTE. The median age of the study population was 69 years; 51.5% were women. After adjusting for potential confounders, compared with those without VTE, patients with colon cancer with VTE had significantly higher inpatient mortality (6.26% vs. 5.52%, OR 1.15, P < .001) and greater disability at discharge (OR 1.38, P < .001), but were not associated with longer length of stay (LOS) or cost of hospitalization. From 2003 to 2011, despite an increase in hospitalization rate with VTE in patients with colon cancer, their mortality steadily declined.
  
  
  
  VTE in hospitalized patients with colon cancer is associated with a significantly higher inpatient mortality and greater disability, but not with longer LOS or cost of hospitalization. Furthermore, even though there has been a trend toward more frequent hospitalizations in this patient population, their mortality continues to decline.
authors: Department of Internal Medicine, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN.
authors: Kalpit
authors: K
authors: Devani
authors: Department of Internal Medicine, Greenville Health System, Greenville, SC.
authors: Nirav
authors: N
authors: Patil
authors: Internal Medicine, John Stroger Hospital of Cook County, Chicago, IL.
authors: Carlos Roberto
authors: CR
authors: Simons-Linares
authors: Department of Internal Medicine, Saint Peter's University Hospital, New Brunswick, NJ.
authors: Nilay
authors: N
authors: Patel
authors: Internal Medicine, John Stroger Hospital of Cook County, Chicago, IL.
authors: Palashkumar
authors: P
authors: Jaiswal
authors: Division of Gastroenterology, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN.
authors: Pranav
authors: P
authors: Patel
authors: Internal Medicine, Western Reserve Health Education, Youngstown, OH.
authors: Samir
authors: S
authors: Patel
authors: Public Health Department, New York Medical College, Valhalla, NY.
authors: Chirag
authors: C
authors: Savani
authors: Appalachian Regional Healthcare/Daniel Boone Oncology Clinic, Harlan, KY.
authors: Kamlesh
authors: K
authors: Sajnani
authors: Division of Gastroenterology, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN.
authors: Mark
authors: M
authors: Young
authors: Division of Gastroenterology, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN. Electronic address: creddy@gianetn.com.
authors: Chakradhar
authors: C
authors: Reddy
mesh_terms: D000328:Adult; D000368:Aged; D003110:Colonic Neoplasms / Q000150:complications* / Q000401:mortality*; D005260:Female; D006760:Hospitalization / Q000191:economics / Q000706:statistics & numerical data; D006801:Humans; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D014481:United States / Q000453:epidemiology; D054556:Venous Thromboembolism / Q000453:epidemiology* / Q000209:etiology*
keywords: Colon cancer; Epidemiology; Inpatients; Venous thromboembolism