title: Age-Specific Dynamics of Corpus Callosum Development in Children and its Peculiarities in Infantile Cerebral Palsy.
abstract: The age dynamics of corpus callosum development was studied on magnetic resonance images of the brain in children aged 2-11 years without neurological abnormalities and with infantile cerebral palsy. The areas of the total corpus callosum and its segments are compared in the midsagittal images. Analysis is carried out with the use of an original formula: proportion of areas of the anterior (genu, CC2; and anterior part, CC3) and posterior (isthmus, CC6 and splenium, CC7) segments: kCC=(CC2+CC3)×CC6/CC7. The results characterize age-specific dynamics of the corpus callosum development and can be used for differentiation, with high confidence, of the brain of children without neurological abnormalities from the brain patients with infantile cerebral palsy.
authors: St. Petersburg State University, St. Petersburg, Russia. krasnelena@bio.spbu.ru.
authors: E I
authors: EI
authors: Krasnoshchekova
authors: St. Petersburg State University, St. Petersburg, Russia.
authors: P A
authors: PA
authors: Zykin
authors: St. Petersburg State University, St. Petersburg, Russia.
authors: L A
authors: LA
authors: Tkachenko
authors: St. Petersburg State University, St. Petersburg, Russia.|St. Petersburg State Pediatric Medical University, Ministry of Health of the Russian Federation, St. Petersburg, Russia.
authors: T A
authors: TA
authors: Aleksandrov
authors: St. Petersburg State University, St. Petersburg, Russia.|St. Petersburg State Pediatric Medical University, Ministry of Health of the Russian Federation, St. Petersburg, Russia.
authors: V M
authors: VM
authors: Sereda
authors: St. Petersburg State Pediatric Medical University, Ministry of Health of the Russian Federation, St. Petersburg, Russia.
authors: A N
authors: AN
authors: Yalfimov
mesh_terms: D000367:Age Factors; D016022:Case-Control Studies; D002547:Cerebral Palsy / Q000175:diagnosis / Q000473:pathology* / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D003337:Corpus Callosum / Q000473:pathology* / Q000503:physiopathology; D018450:Disease Progression; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male
keywords: corpus callosum; infantile cerebral palsy; morphometry