title: Re-evaluating the link between neuropsychiatric disorders and dysregulated adult neurogenesis.
abstract: People diagnosed with neuropsychiatric disorders such as depression, anxiety, addiction or schizophrenia often have dysregulated memory, mood, pattern separation and/or reward processing. These symptoms are indicative of a disrupted function of the dentate gyrus (DG) subregion of the brain, and they improve with treatment and remission. The dysfunction of the DG is accompanied by structural maladaptations, including dysregulation of adult-generated neurons. An increasing number of studies using modern inducible approaches to manipulate new neurons show that the behavioral symptoms in animal models of neuropsychiatric disorders can be produced or exacerbated by the inhibition of DG neurogenesis. Thus, here we posit that the connection between neuropsychiatric disorders and dysregulated DG neurogenesis is beyond correlation or epiphenomenon, and that the regulation of adult-generated DG neurogenesis merits continued and focused attention in the ongoing effort to develop novel treatments for neuropsychiatric disorders.
authors: Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
authors: Sanghee
authors: S
authors: Yun
authors: Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
authors: Ryan P
authors: RP
authors: Reynolds
authors: Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
authors: Irene
authors: I
authors: Masiulis
authors: Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.|Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas, USA.|Department of Neuroscience and Mahoney Institute of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
authors: Amelia J
authors: AJ
authors: Eisch
mesh_terms: D000328:Adult; D000339:Affect; D000818:Animals; D001008:Anxiety Disorders / Q000503:physiopathology; D001921:Brain / Q000503:physiopathology; D018891:Dentate Gyrus / Q000166:cytology / Q000503:physiopathology*; D003866:Depressive Disorder / Q000503:physiopathology; D006801:Humans; D008568:Memory; D001523:Mental Disorders / Q000503:physiopathology*; D055495:Neurogenesis / Q000502:physiology*; D009474:Neurons; D012201:Reward; D012559:Schizophrenia / Q000503:physiopathology; D019966:Substance-Related Disorders / Q000503:physiopathology