title: A New Caged-Glutamine Derivative as a Tool To Control the Assembly of Glutamine-Containing Amyloidogenic Peptides.
abstract: We present the design, synthesis, and characterization of a novel photocaged glutamine derivative (modified on the side chain of glutamine), and describe its use in enhancing peptide stability and solubility. Our results demonstrate that this approach can be used to develop molecular switches to control the folding and β-sheet formation of amyloidogenic peptides.
authors: College of Engineering, University of Dammam, P. O. Box 1982, Dammam, 31451, Saudi Arabia.
authors: Loay
authors: L
authors: Awad
authors: Laboratory of Molecular and Chemical Biology of Neurodegeneration, Ecole Polytechnique Fédérale de Lausanne, EPFL), 1015, Lausanne, Switzerland.
authors: Nino
authors: N
authors: Jejelava
authors: Laboratory of Molecular and Chemical Biology of Neurodegeneration, Ecole Polytechnique Fédérale de Lausanne, EPFL), 1015, Lausanne, Switzerland.
authors: Ritwik
authors: R
authors: Burai
authors: Laboratory of Molecular and Chemical Biology of Neurodegeneration, Ecole Polytechnique Fédérale de Lausanne, EPFL), 1015, Lausanne, Switzerland.
authors: Hilal A
authors: HA
authors: Lashuel
mesh_terms: D000595:Amino Acid Sequence; D016229:Amyloid beta-Peptides / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism*; D002942:Circular Dichroism; D057930:Click Chemistry; D005973:Glutamine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D046529:Microscopy, Electron, Transmission; D010782:Photolysis; D017510:Protein Folding; D055550:Protein Stability; D017433:Protein Structure, Secondary; D012995:Solubility; D014466:Ultraviolet Rays
chemical_list: D016229:Amyloid beta-Peptides; D005973:Glutamine
keywords: amyloid beta-peptides; beta-sheet structure; neurodegenerative disease; photocleavage linker; protein folding