title: 45 years after the discovery of human polyomaviruses BK and JC: Time to speed up the understanding of associated diseases and treatment approaches.
abstract: Nearly 45 years after the discovery of the first two human polyomaviruses BK and JC, their life-long persistence and mechanisms of pathogenesis remain poorly understood and efficient antiviral treatments are severely lacking. In this review, we sought to provide an update on recent advances in understanding the life cycle of these two viruses, particularly focusing on their interaction with the host immune system and pathogenesis. We have also discussed novel treatment approaches and highlighted areas of future research.
authors: a Laboratoire de Virologie , Hôpitaux Universitaires de Strasbourg , Strasbourg , France.|b INSERM UMR_S1109, LabEx Transplantex, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg , Strasbourg , France.
authors: Heidi
authors: H
authors: Barth
authors: a Laboratoire de Virologie , Hôpitaux Universitaires de Strasbourg , Strasbourg , France.|b INSERM UMR_S1109, LabEx Transplantex, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg , Strasbourg , France.
authors: Morgane
authors: M
authors: Solis
authors: a Laboratoire de Virologie , Hôpitaux Universitaires de Strasbourg , Strasbourg , France.|b INSERM UMR_S1109, LabEx Transplantex, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg , Strasbourg , France.
authors: Quentin
authors: Q
authors: Lepiller
authors: a Laboratoire de Virologie , Hôpitaux Universitaires de Strasbourg , Strasbourg , France.|b INSERM UMR_S1109, LabEx Transplantex, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg , Strasbourg , France.
authors: Charlotte
authors: C
authors: Sueur
authors: b INSERM UMR_S1109, LabEx Transplantex, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg , Strasbourg , France.
authors: Eric
authors: E
authors: Soulier
authors: b INSERM UMR_S1109, LabEx Transplantex, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg , Strasbourg , France.|c Département de Néphrologie et Transplantation , Hôpitaux Universitaires de Strasbourg , Strasbourg , France.
authors: Sophie
authors: S
authors: Caillard
authors: a Laboratoire de Virologie , Hôpitaux Universitaires de Strasbourg , Strasbourg , France.|b INSERM UMR_S1109, LabEx Transplantex, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg , Strasbourg , France.
authors: Françoise
authors: F
authors: Stoll-Keller
authors: a Laboratoire de Virologie , Hôpitaux Universitaires de Strasbourg , Strasbourg , France.|b INSERM UMR_S1109, LabEx Transplantex, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg , Strasbourg , France.
authors: Samira
authors: S
authors: Fafi-Kremer
mesh_terms: D001739:BK Virus / Q000276:immunology / Q000302:isolation & purification* / Q000472:pathogenicity; D035843:Biomedical Research / Q000639:trends*; D049673:History, 20th Century; D049674:History, 21st Century; D054884:Host-Pathogen Interactions; D006801:Humans; D007577:JC Virus / Q000276:immunology / Q000302:isolation & purification* / Q000472:pathogenicity; D027601:Polyomavirus Infections / Q000473:pathology* / Q000628:therapy*; D014773:Virology / Q000266:history* / Q000639:trends
keywords: Viral persistence; anti-viral immunity; polyomavirus-associated nephropathy; progressive multifocal leukoencephalopathy; treatment