title: Implication of vaccination against dengue for Zika outbreak.
abstract: Zika virus co-circulates with dengue in tropical and sub-tropical regions. Cases of co-infection by dengue and Zika have been reported, the implication of this co-infection for an integrated intervention program for controlling both dengue and Zika must be addressed urgently. Here, we formulate a mathematical model to describe the transmission dynamics of co-infection of dengue and Zika with particular focus on the effects of Zika outbreak by vaccination against dengue among human hosts. Our analysis determines specific conditions under which vaccination against dengue can significantly increase the Zika outbreak peak, and speed up the Zika outbreak peak timing. Our results call for further study about the co-infection to direct an integrated control to balance the benefits for dengue control and the damages of Zika outbreak.
authors: School of Mathematics and Statistics, Xi'an Jiaotong University, Xi'an 710049, PR China.|Centre for Disease Modelling, York Institute for Health Research, York University, Toronto, ON, M3J 1P3, Canada.
authors: Biao
authors: B
authors: Tang
authors: School of Mathematics and Statistics, Xi'an Jiaotong University, Xi'an 710049, PR China.
authors: Yanni
authors: Y
authors: Xiao
authors: Centre for Disease Modelling, York Institute for Health Research, York University, Toronto, ON, M3J 1P3, Canada.
authors: Jianhong
authors: J
authors: Wu
mesh_terms: D000818:Animals; D060085:Coinfection / Q000453:epidemiology / Q000276:immunology / Q000517:prevention & control; D003715:Dengue / Q000453:epidemiology / Q000276:immunology* / Q000517:prevention & control*; D004196:Disease Outbreaks / Q000517:prevention & control*; D006801:Humans; D007303:Insect Vectors / Q000821:virology; D008962:Models, Theoretical; D014611:Vaccination / Q000379:methods; D000071244:Zika Virus / Q000276:immunology*; D000071243:Zika Virus Infection / Q000453:epidemiology / Q000276:immunology* / Q000517:prevention & control*