title: The effect of the type of HA on the degradation of PLGA/HA composites.
abstract: The aim of this study is to explore the importance of the potentially competing effects of buffering effects of the calcium phosphate filler and particle-mediated water sorption on the degradation products of poly(d,l lactide-co-glycolide (50:50))(PLGA)/hydroxyapatite(HA) composites. Further the influence of type of HA on the mechanical properties of the composites was investigated. Phase pure HA was synthesised via a reaction between aqueous solutions of calcium hydroxide and orthophosphoric acid. The powder produced was either used as produced (uncalcined) or calcined in air or calcined in a humidified argon atmosphere. An in-vitro degradation study was carried out in phosphate buffered saline (PBS). The results obtained indicated that the degradation rate of the composite might be better understood if both the buffering effects and the rate of water sorption by the composites are considered.
authors: Cambridge Centre for Medical Materials, University of Cambridge, Department of Materials Science and Metallurgy, 27, Charles Babbage Road, Cambridge CB3 0FS, UK. Electronic address: naikashutosh@gmail.com.
authors: Ashutosh
authors: A
authors: Naik
authors: Cambridge Centre for Medical Materials, University of Cambridge, Department of Materials Science and Metallurgy, 27, Charles Babbage Road, Cambridge CB3 0FS, UK.
authors: David V
authors: DV
authors: Shepherd
authors: Cambridge Centre for Medical Materials, University of Cambridge, Department of Materials Science and Metallurgy, 27, Charles Babbage Road, Cambridge CB3 0FS, UK.
authors: Jennifer H
authors: JH
authors: Shepherd
authors: Cambridge Centre for Medical Materials, University of Cambridge, Department of Materials Science and Metallurgy, 27, Charles Babbage Road, Cambridge CB3 0FS, UK.
authors: Serena M
authors: SM
authors: Best
authors: Cambridge Centre for Medical Materials, University of Cambridge, Department of Materials Science and Metallurgy, 27, Charles Babbage Road, Cambridge CB3 0FS, UK.
authors: Ruth E
authors: RE
authors: Cameron
mesh_terms: D002118:Calcium / Q000032:analysis; D017886:Durapatite / Q000737:chemistry*; D055119:Elastic Modulus; D006863:Hydrogen-Ion Concentration; D019344:Lactic Acid / Q000737:chemistry*; D008970:Molecular Weight; D010316:Particle Size; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011208:Powders; D012996:Solutions; D013696:Temperature; D014867:Water / Q000737:chemistry; D014961:X-Ray Diffraction
chemical_list: D011208:Powders; D012996:Solutions; D014867:Water; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D017886:Durapatite; D002118:Calcium
keywords: Buffering effects; Hydroxyapatite; Particle-mediated water sorption; Poly(d,l lactide-co-glycolide (50:50))