title: Total Synthesis of Swinholide A: An Exposition in Hydrogen-Mediated C-C Bond Formation.
abstract: Diverse hydrogen-mediated C-C couplings enable construction of the actin-binding marine polyketide swinholide A in only 15 steps (longest linear sequence), roughly half the steps required in two prior total syntheses. The redox-economy, chemo- and stereoselectivity embodied by this new class of C-C couplings are shown to evoke a step-change in efficiency.
authors: University of Texas at Austin, Department of Chemistry, Austin, TX 78712, USA.
authors: Inji
authors: I
authors: Shin
authors: University of Texas at Austin, Department of Chemistry, Austin, TX 78712, USA.
authors: Suckchang
authors: S
authors: Hong
authors: University of Texas at Austin, Department of Chemistry, Austin, TX 78712, USA.
authors: Michael J
authors: MJ
authors: Krische
mesh_terms: D002244:Carbon / Q000737:chemistry*; D060326:Chemistry Techniques, Synthetic; D006859:Hydrogen / Q000737:chemistry*; D008387:Marine Toxins / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D008387:Marine Toxins; D002244:Carbon; D006859:Hydrogen; C086235:swinholide A