title: Expression of lncRNA HULC in cervical cancer and its correlation with tumor progression and patient survival.
abstract: To investigate Long non-coding RNA HULC (HULC) expression in cervical cancer and to evaluate its clinical significance.
  
  
  
  HULC expression in 244 pairs of human cervical cancer and adjacent normal tissues was detected by real-time quantitative RT-PCR assay. The correlation between HULC and clinicopathological factors was also evaluated. The clinical and prognostic significance of HULC expression was analyzed statistically by Kaplan-Meier estimate and Cox regression model.
  
  
  
  HULC expression was high in cervical cancer (p < 0.01). Also, the high HULC expression was significantly associated with the FIGO stage, lymph node metastasis and depth of cervical invasion (p < 0.05). Kaplan-Meier analysis showed that cervical cancer pa¬tients with high expression of HULC possessed poorer outcome than those with low expression of HULC (p < 0.001). Based on the univariate and multivariate analysis, the elevated expression of the HULC protein was a significant predictor of poor prognosis for cervical cancer patients (p = 0.001).
  
  
  
  Our data firstly showed that the expression of HULC was upregulated in cervical cancer, and associated with overall survival, indicating that HULC may serve as a predictive biomarker for the prognosis of cervical cancer.
authors: Department of Gynaecology and Obstetrics, Henan Provincial People's Hospital and Zhengzhou University People's Hospital, Zhengzhou, China. wyf901@126.com.
authors: Y-F
authors: YF
authors: Wang
authors: S
authors: S
authors: Zhang
authors: X-Q
authors: XQ
authors: Li
authors: Y
authors: Y
authors: Wang
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008875:Middle Aged; D011379:Prognosis; D062085:RNA, Long Noncoding / Q000235:genetics*; D060888:Real-Time Polymerase Chain Reaction; D015854:Up-Regulation; D002583:Uterine Cervical Neoplasms / Q000235:genetics*
chemical_list: D014408:Biomarkers, Tumor; C574685:HULC long non-coding RNA, human; D062085:RNA, Long Noncoding