title: Clinical Results for Bladder Cancer Treated by Radiotherapy Without Concurrent Standard Chemotherapy.
abstract: To evaluate clinical outcomes of three-dimensional conformal radiotherapy (3D-CRT) alone in patients with bladder cancer who were unfit for concurrent standard chemotherapy.
  
  
  
  Between January 2007 and May 2016, 34 patients (20 men, 14 women) aged 65-97 years (median=83) with bladder cancer cT1-4bN0-1M1 were treated with conformal whole-bladder radiotherapy with fractions of 1.8-3 Gy up to a total dose of 40-50 Gy.
  
  
  
  Median survival was 10 months (range=1-99); 1-year and 3-year survival was 51.4% and 34.3%, respectively. Radiation dose >50 Gy was associated with improved survival. Three-year local control (LC) rate was 58.8%. On multivariate analysis, only radiation dose showed a significant association with LC.
  
  
  
  Our results demonstrated the safety and feasibility of radiotherapy in patients with bladder cancer unfit for concurrent standard chemotherapy. A higher radiation dose may confer superior LC and overall survival (OS) without complications.
authors: Department of Radiology, Nihon University School of Medicine, Tokyo, Japan sakaguchi.masakuni@nihon-u.ac.jp.
authors: Masakuni
authors: M
authors: Sakaguchi
authors: Department of Radiology, Nihon University School of Medicine, Tokyo, Japan.
authors: Toshiya
authors: T
authors: Maebayashi
authors: Department of Radiology, Nihon University School of Medicine, Tokyo, Japan.
authors: Takuya
authors: T
authors: Aizawa
authors: Department of Radiology, Nihon University School of Medicine, Tokyo, Japan.
authors: Naoya
authors: N
authors: Ishibashi
authors: Sonodakai Radiation Oncology Clinic, Tokyo, Japan.
authors: Tsutomu
authors: T
authors: Saito
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008297:Male; D061214:Patient Safety; D012189:Retrospective Studies; D015996:Survival Rate; D001749:Urinary Bladder Neoplasms / Q000532:radiotherapy*
keywords: Concurrent chemoradiotherapy; bladder cancer; three-dimensional conformal radiotherapy; whole-bladder radiotherapy