title: The potential use of urine cell free DNA as a marker for cancer.
abstract: Although the role of circulating cell free DNA in cancer has been widely demonstrated, less is known about the role of urine cell free DNA (UcfDNA). UcfDNA can serve as a 'liquid biopsy' for urological and non-urological tumors, as it carries information on DNA from cells exfoliated in urine and from circulation. Areas covered: We review the studies on UcfDNA as a source of biomarkers for cancer, focusing on the new techniques and the differences between urological and non-urological tumors. We searched Pubmed for articles published between 1998 and 2016 with the following key words and phrases: 'urine' and 'cell free DNA' or 'liquid biopsy' or 'cancer'. Expert commentary: Despite the few papers published on this topic, UcfDNA is an important component of 'liquid biopsy', a useful and non-invasive tool for cancer diagnosis, prognosis and treatment monitoring, containing a wide range of genetic information.
authors: a Biosciences Laboratory , Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS , Meldola , Italy.
authors: Samanta
authors: S
authors: Salvi
authors: a Biosciences Laboratory , Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS , Meldola , Italy.
authors: Filippo
authors: F
authors: Martignano
authors: a Biosciences Laboratory , Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS , Meldola , Italy.
authors: Chiara
authors: C
authors: Molinari
authors: a Biosciences Laboratory , Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS , Meldola , Italy.
authors: Giorgia
authors: G
authors: Gurioli
authors: a Biosciences Laboratory , Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS , Meldola , Italy.
authors: Daniele
authors: D
authors: Calistri
authors: b Department of Medical Oncology , Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS , Meldola , Italy.
authors: Ugo
authors: U
authors: De Giorgi
authors: b Department of Medical Oncology , Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS , Meldola , Italy.
authors: Vincenza
authors: V
authors: Conteduca
authors: a Biosciences Laboratory , Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS , Meldola , Italy.
authors: Valentina
authors: V
authors: Casadio
mesh_terms: D014408:Biomarkers, Tumor; D001706:Biopsy; D019175:DNA Methylation; D004252:DNA Mutational Analysis; D004273:DNA, Neoplasm / Q000652:urine*; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans; D053842:Microsatellite Instability; D009369:Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000652:urine*; D014571:Urologic Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000652:urine
chemical_list: D014408:Biomarkers, Tumor; D004273:DNA, Neoplasm
keywords: Urine; cancer; cell free DNA; liquid biopsy; markers