title: [Paradoxical reaction following antituberculosis therapy in immunocompetent patient].
abstract: BACKGROUND
  The features of paradoxical reactions (PR) that occurred in non-HIV infected patients are rare and not well known.
  
  
  METHODS
  The authors reported the case of a 21years old, non-immunocompromised, and HIV negative patient treated for disseminated tuberculosis. PR occurred after 8months after initiation of antituberculous treatment. PR presented as left cervical lymphadenopathy, pulmonary, pleural, costal and spinal location of the tuberculosis. The antituberculous drugs were prolonged. Patient's clinical symptoms improved initially. However, left inguinal lymphadenopathy appeared after 20months of antituberculous therapy. Inguinal lymph node biopsy revealed tuberculous lymphadenitis. The patient has a good compliance to the treatment. The patient was continued on same antituberculous treatment for a total of 28months. The cervical and inguinal lymphadenopathy disappeared and CT scan showed regression of thoracic, abdominal, costal and spinal lesions.
  
  
  CONCLUSIONS
  PR during antituberculous treatment must be considered after exclusion of other causes. No consensus on the therapeutic management of this entity has been developed to date.
authors: Service de pneumologie, hôpital Abderrahmane Mami, pavillon 2 Ariana, Tunisie. Electronic address: saoussenbacha@yahoo.fr.
authors: S
authors: S
authors: Bacha
authors: Service de pneumologie, hôpital Abderrahmane Mami, pavillon 2 Ariana, Tunisie.
authors: M
authors: M
authors: Khemiri
authors: Service de pneumologie, hôpital Abderrahmane Mami, pavillon 2 Ariana, Tunisie.
authors: H
authors: H
authors: Racil
authors: Service de radiologie, hôpital Abderrahmane Mami, Ariana, Tunisie.
authors: S
authors: S
authors: Hantous
authors: Service de pneumologie, hôpital Abderrahmane Mami, pavillon 2 Ariana, Tunisie.
authors: N
authors: N
authors: Chaouch
authors: Service de pneumologie, hôpital Abderrahmane Mami, pavillon 2 Ariana, Tunisie.
authors: S
authors: S
authors: Cheikhrouhou
authors: Service de pneumologie, hôpital Abderrahmane Mami, pavillon 2 Ariana, Tunisie.
authors: A
authors: A
authors: Chabbou
authors: Service de pneumologie, hôpital Abderrahmane Mami, pavillon 2 Ariana, Tunisie.
authors: M L
authors: ML
authors: Megdiche
mesh_terms: D000995:Antitubercular Agents / Q000627:therapeutic use*; D006801:Humans; D007121:Immunocompetence; D008198:Lymph Nodes / Q000187:drug effects / Q000473:pathology; D008297:Male; D009333:Neck; D010388:Pelvis; D014388:Tuberculosis, Lymph Node / Q000139:chemically induced*; D014391:Tuberculosis, Miliary / Q000188:drug therapy*; D055815:Young Adult
chemical_list: D000995:Antitubercular Agents
keywords: Adénopathie paradoxale; Antituberculeux; Antituberculous treatment; Management; Paradoxical lymphadenopathy; Paradoxical reaction; Prise en charge; Réaction paradoxale; Tuberculose; Tuberculosis