title: New treatment strategies for HIV-positive cancer patients undergoing antiblastic chemotherapy.
abstract: The introduction of Highly Active Antiretroviral Therapy (HAART) into clinical practice has dramatically changed the outcome of HIV-infected patients by prolonging their survival. The increase in life expectancy has led to an increased risk of non-AIDS-related mortality and morbidity, including cardiovascular diseases, neurocognitive diseases, neuroendocrine dysfunctions and cancer. Areas covered: The GICAT (Italian Cooperation Group on AIDS and Tumors) has demonstrated that patients who receive a multidisciplinary approach with the combination of anticancer agents (AC) and HAART can achieve better responses and survival rates than patients who receive AC alone. The first obstacle for the oncologist to plan treatment for cancer HIV-patients is the preliminary evaluation of drug-drug interactions between AC and HAART. Recent progress in pharmacogenomics could provide a new approach for personalized treatments. The rationale of this review is to summarize the existing data on the impact of HAART on the clinical management of cancer patients with HIV/AIDS and DDIs between antiretrovirals and AC. In addition, to maximize the efficacy of both concomitant therapy and to minimize the risk of DDIs, a currently useful list of pharmacogenomic markers of key metabolic enzymes is provided. Expert opinion: In this scenario, the importance of cooperation between oncologists and other health specialists (i.e., infectivologists, pharmacists, genetics and lab specialists) must not be underestimated in the management of these patients with the aim of planning an individual treatment strategy.
authors: a Department of Medical Oncology , National Cancer Institute , Aviano , Italy.
authors: Massimiliano
authors: M
authors: Berretta
authors: b Hematology-Oncology and Stem Cell Transplantation Unit , National Cancer Institute, Fondazione 'G. Pascale' IRCCS , Naples , Italy.
authors: Raffaele
authors: R
authors: Di Francia
authors: a Department of Medical Oncology , National Cancer Institute , Aviano , Italy.
authors: Brigida
authors: B
authors: Stanzione
authors: c Division of Medical Oncology, Department of Uro-Gynecological Oncology , Istituto Nazionale Tumori 'Fondazione G. Pascale' - IRCCS , Naples , Italy.
authors: Gaetano
authors: G
authors: Facchini
authors: a Department of Medical Oncology , National Cancer Institute , Aviano , Italy.
authors: Arben
authors: A
authors: LLeshi
authors: d Scientific Directorate , National Cancer Institute , Aviano , Italy.
authors: Paolo
authors: P
authors: De Paoli
authors: a Department of Medical Oncology , National Cancer Institute , Aviano , Italy.
authors: Michele
authors: M
authors: Spina
authors: a Department of Medical Oncology , National Cancer Institute , Aviano , Italy.
authors: Umberto
authors: U
authors: Tirelli
mesh_terms: D019380:Anti-HIV Agents / Q000008:administration & dosage*; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D023241:Antiretroviral Therapy, Highly Active / Q000379:methods*; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D015658:HIV Infections / Q000175:diagnosis / Q000188:drug therapy* / Q000453:epidemiology; D006801:Humans; D007558:Italy / Q000453:epidemiology; D009369:Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000453:epidemiology; D016896:Treatment Outcome
chemical_list: D019380:Anti-HIV Agents; D000970:Antineoplastic Agents
keywords: AIDS; Drug metabolism; cancer; cytochrome P450; individualized therapy; pharmacogenetics; pharmacogenomics