title: Maternal Metabolism and Vascular Adaptation in Pregnancy: The PPAR Link.
abstract: Current therapies for pregnancy-related hypertension and its complications remain inadequate, although an increasing role for maternal susceptibility is becoming evident. Systemic vascular dysfunction in response to imbalances in angiogenic, inflammatory, and constricting factors is implicated in the pathogenesis of gestational hypertension, and growing evidence now links these factors with maternal metabolism. In particular, the crucial role of peroxisome proliferator-activated receptors (PPARs) in maternal vascular adaptation provides further insights into how obesity and gestational diabetes may be linked to pregnancy-induced hypertension and preeclampsia. This is especially important given the rapidly growing prevalence of obesity during pregnancy, and highlights a new approach to treat pregnancy-related hypertension and its complications.
authors: Vascular Biology and Stromal Targeting, Harry Perkins Institute of Medical Research, The University of Western Australia, Centre for Medical Research, Nedlands, Western Australia 6009, Australia. Electronic address: ganss@perkins.uwa.edu.au.
authors: Ruth
authors: R
authors: Ganss
mesh_terms: D000818:Animals; D001808:Blood Vessels / Q000378:metabolism; D016640:Diabetes, Gestational / Q000378:metabolism; D005260:Female; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000235:genetics / Q000378:metabolism; D047492:Peroxisome Proliferator-Activated Receptors / Q000235:genetics / Q000378:metabolism*; D011225:Pre-Eclampsia / Q000378:metabolism; D011247:Pregnancy; D020710:RGS Proteins / Q000378:metabolism
chemical_list: D047492:Peroxisome Proliferator-Activated Receptors; D020710:RGS Proteins
keywords: PPAR; RGS5; blood vessel; metabolism; preeclampsia; pregnancy