title: Adverse effects of Croton urucurana B. exposure during rat pregnancy.
abstract: BACKGROUND
  Croton urucurana presents several beneficial pharmacological properties. In Brazil, women who intend to interrupt the pregnancy indiscriminately use extracts of this plant as an abortifacient agent.
  
  
  OBJECTIVE
  To evaluated the effect of aqueous extract of Croton urucurana latex on the maternal-fetal repercussions in rats.
  
  
  METHODS
  Pregnant rats were randomly distributed into four experimental groups: Control=treated with water (vehicle); Treated 200=treated with a dose 200mg/kg; Treated 400=dose 400mg/kg and; and Treated 800=dose 800mg/kg. The rats were orally treated by gavage with Croton urucurana or vehicle (water) during whole pregnancy. At term of pregnancy, all rats were killed to obtain maternal blood and tissues samples and fetal weight and anomaly analyses.
  
  
  RESULTS
  C. urucurana treatment (Treated 400 and Treated 800) showed elevated liver enzymatic activities, reduced fetal body weight and placental efficiency. The Treated 800 group presented increased maternal total protein and cholesterol levels, and heart relative weight. All treated groups presented reduced maternal body weight and food intake, and increased pre-implantation loss rate compared to those of Control group. In addition, the treatment contributed to increased skeletal and visceral anomalies with higher doses.
  
  
  CONCLUSIONS
  Croton urucurana treatment caused maternal toxicity, which contributed for impairment embryo fetal development. These results showed that the indiscriminate use of plants during pregnancy should be avoided to prevent potential risk on maternal health as well as their offspring.
authors: Laboratory of System Physiology and Reproductive Toxicology, Institute of Biological and Health Sciences, Federal University of Mato Grosso (UFMT), Barra do Garças, Mato Grosso, Brazil.
authors: Rafaianne Queiroz
authors: RQ
authors: Moraes-Souza
authors: Laboratory of System Physiology and Reproductive Toxicology, Institute of Biological and Health Sciences, Federal University of Mato Grosso (UFMT), Barra do Garças, Mato Grosso, Brazil.
authors: Thaigra Sousa
authors: TS
authors: Soares
authors: Laboratory of System Physiology and Reproductive Toxicology, Institute of Biological and Health Sciences, Federal University of Mato Grosso (UFMT), Barra do Garças, Mato Grosso, Brazil.
authors: Nágilla Orleanne Lima
authors: NO
authors: Carmo
authors: Laboratory of Experimental Research on Gynecology and Obstetrics, Graduate Course of Gynecology, Obstetrics and Mastology, Univ Estadual Paulista_Unesp, Botucatu, São Paulo, Brazil.
authors: Débora Cristina
authors: DC
authors: Damasceno
authors: Laboratory of System Physiology and Reproductive Toxicology, Institute of Biological and Health Sciences, Federal University of Mato Grosso (UFMT), Barra do Garças, Mato Grosso, Brazil; Laboratory of Experimental Research on Gynecology and Obstetrics, Graduate Course of Gynecology, Obstetrics and Mastology, Univ Estadual Paulista_Unesp, Botucatu, São Paulo, Brazil.
authors: Kleber Eduardo
authors: KE
authors: Campos
authors: Laboratory of System Physiology and Reproductive Toxicology, Institute of Biological and Health Sciences, Federal University of Mato Grosso (UFMT), Barra do Garças, Mato Grosso, Brazil; Laboratory of Experimental Research on Gynecology and Obstetrics, Graduate Course of Gynecology, Obstetrics and Mastology, Univ Estadual Paulista_Unesp, Botucatu, São Paulo, Brazil. Electronic address: gtvolpato@yahoo.com.
authors: Gustavo Tadeu
authors: GT
authors: Volpato
mesh_terms: D000019:Abortifacient Agents / Q000302:isolation & purification / Q000633:toxicity*; D000818:Animals; D029802:Croton; D005260:Female; D008297:Male; D010936:Plant Extracts / Q000302:isolation & purification / Q000633:toxicity*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced* / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000019:Abortifacient Agents; D010936:Plant Extracts
keywords: Croton urucurana; Malformation; Plant; Pregnancy; Toxicity