title: Open airway reconstruction in adults: Outcomes and prognostic factors.
abstract: OBJECTIVE
  The purpose was to assess the success of open tracheal resection and re-anastomosis for non-malignant tracheal stenosis in adults. Successful operations were defined as T-tube or tracheostomy-free status by 6months post-operatively.
  
  
  METHODS
  Retrospective chart review was performed and data were recorded in a de-identified manner. The primary outcome was T-tube or tracheostomy-free status by 6months following tracheal resection. Clinical and demographic characteristics were evaluated as potential prognostic variables.
  
  
  RESULTS
  Thirty-two patients met inclusion criteria, with a median age of 46. Seven patients underwent tracheal resection with primary closure, without stenting. Successful tracheal resection was defined as tracheostomy or T-tube free by 6months post-operation, and this was possible in 21 patients (66%). Eighty-two percent of patients with cricoid cartilage-sparing tracheal resection had a successful outcome, versus 30% of patients who underwent cricoid cartilage resection (HR 5.02, 95% CI 1.46-17.3; p=0.011). Patients with a history of tracheostomy-dependence were four times more likely to remain tube-dependent at 6months (HR 4.15, 95% CI 1.56-10.86; p=0.004).
  
  
  CONCLUSIONS
  Tracheal stenosis remains a very difficult problem to treat. In our series, we confirm that patients with cricoid involvement or with a history of tracheostomy were more likely to be tube dependent at 6-months post-operation.
authors: University of Miami Miller School of Medicine, Miami, FL, USA.
authors: Marianne
authors: M
authors: Abouyared
authors: University of Miami Miller School of Medicine, Miami, FL, USA.
authors: Mikhaylo
authors: M
authors: Szczupak
authors: University of Miami Miller School of Medicine, Miami, FL, USA.
authors: Eric
authors: E
authors: Barbarite
authors: University of Miami Miller School of Medicine, Miami, FL, USA.
authors: Zoukaa B
authors: ZB
authors: Sargi
authors: University of Miami Miller School of Medicine, Miami, FL, USA. Electronic address: drosow@med.miami.edu.
authors: David E
authors: DE
authors: Rosow
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D000714:Anastomosis, Surgical; D001999:Bronchoscopy / Q000379:methods; D015331:Cohort Studies; D003413:Cricoid Cartilage; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D053208:Kaplan-Meier Estimate; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D059351:Organ Sparing Treatments / Q000379:methods*; D012189:Retrospective Studies; D018570:Risk Assessment; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric; D013997:Time Factors; D014132:Trachea / Q000601:surgery*; D014135:Tracheal Stenosis / Q000175:diagnosis / Q000601:surgery*; D014139:Tracheostomy / Q000009:adverse effects / Q000379:methods*; D016896:Treatment Outcome; D064706:Vocal Cord Dysfunction / Q000517:prevention & control; D055815:Young Adult