title: Outcomes of Allogeneic Hematopoietic Stem Cell Transplantation in Adult Patients with Myelodysplastic Syndrome Harboring Trisomy 8.
abstract: Trisomy 8 (+8) is 1 of the most common cytogenetic abnormalities in adult patients with myelodysplastic syndrome (MDS). However, the outcome of allogeneic hematopoietic stem cell transplantation (HSCT) in adult patients with MDS harboring +8 remains unclear. To evaluate the outcome and prognostic factors in patients with MDS harboring +8 as the sole cytogenetic abnormality or in association with other abnormalities, we retrospectively analyzed the Japanese registration data of 381 adult patients with MDS harboring +8 treated with allogeneic HSCT between 1990 and 2013. With a median follow-up period of 53 months, the probability of overall survival and cumulative incidence of relapse at 4 years were 51% and 22%, respectively. In the multivariate analysis, age > 50 years, 2 or more additional cytogenetic abnormalities, and a high risk at the time of HSCT according to the FAB/WHO classification were significantly associated with a higher overall mortality. Nevertheless, no significant impact of the outcome was observed in patients with 1 cytogenetic abnormality in addition to +8. Although 221 patients (58%) had advanced MDS at the time of HSCT, allogeneic HSCT offered a curative option for adult patients with MDS harboring +8.
authors: Department of Hematology/Oncology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan. Electronic address: tkonuma@ims.u-tokyo.ac.jp.
authors: Takaaki
authors: T
authors: Konuma
authors: Department of Hematology, Atomic Bomb Disease and Hibakusha Medicine Unit, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Japan.
authors: Yasushi
authors: Y
authors: Miyazaki
authors: Department of Hematology, Toranomon Hospital, Tokyo, Japan.
authors: Naoyuki
authors: N
authors: Uchida
authors: Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan.
authors: Kazuteru
authors: K
authors: Ohashi
authors: Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors: Tadakazu
authors: T
authors: Kondo
authors: Hematology, Graduate School of Medicine, Osaka City University, Osaka, Japan.
authors: Hirohisa
authors: H
authors: Nakamae
authors: Division of Molecular Therapy, The Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
authors: Satoshi
authors: S
authors: Takahashi
authors: Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
authors: Takehiko
authors: T
authors: Mori
authors: Department of Hematology, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan.
authors: Yukiyasu
authors: Y
authors: Ozawa
authors: Department of Hematology, Meitetsu Hospital, Nagoya, Japan.
authors: Chiaki
authors: C
authors: Kato
authors: Department of Hematology, Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital, Hiroshima, Japan.
authors: Koji
authors: K
authors: Iwato
authors: Department of Hematopoietic Stem Cell Transplantation Division, National Cancer Center Hospital, Tokyo, Japan.
authors: Takahiro
authors: T
authors: Fukuda
authors: Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan.
authors: Tatsuo
authors: T
authors: Ichinohe
authors: Japanese Data Center for Hematopoietic Cell Transplantation, Nagoya, Japan; Department of Healthcare Administration, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors: Yoshiko
authors: Y
authors: Atsuta
authors: Department of Hematology, Kanazawa University Hospital, Kanazawa, Ishikawa, Japan.
authors: Ken
authors: K
authors: Ishiyama
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002898:Chromosomes, Human, Pair 8; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods* / Q000401:mortality; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000235:genetics* / Q000401:mortality / Q000628:therapy*; D011379:Prognosis; D012008:Recurrence; D012042:Registries / Q000706:statistics & numerical data; D012189:Retrospective Studies; D012307:Risk Factors; D016019:Survival Analysis; D014184:Transplantation, Homologous; D016896:Treatment Outcome; D014314:Trisomy; D055815:Young Adult
keywords: Additional abnormality; Allogeneic hematopoietic stem cell transplantation; Cytogenetics; Myelodysplastic syndrome; Trisomy 8