title: Dimeric furanocoumarins from the roots of Angelica dahurica.
abstract: Three new dimeric furanocoumarins, dahuribiethrins H-J (1-3), and a new ester coumarin, dahurinol A (4), were isolated from the roots of Angelica dahurica. Their structures were elucidated on the basis of extensive spectroscopic data including UV, IR, HRESIMS, 1D and 2D NMR. Compounds 2 and 3 exhibited inhibition of nitric oxide production in the lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage cells with IC50values of 8.7 ± 0.6 and 27.3 ± 0.9 μM, respectively.
authors: a Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine , Beijing , China.|b School of Chinese Materia Medica , Beijing University of Chinese Medicine , Beijing , China.
authors: Wan-Qing
authors: WQ
authors: Yang
authors: a Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine , Beijing , China.
authors: Zhi-Xiang
authors: ZX
authors: Zhu
authors: a Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine , Beijing , China.
authors: Yue-Lin
authors: YL
authors: Song
authors: a Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine , Beijing , China.|b School of Chinese Materia Medica , Beijing University of Chinese Medicine , Beijing , China.
authors: Bo-Wen
authors: BW
authors: Qi
authors: a Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine , Beijing , China.|b School of Chinese Materia Medica , Beijing University of Chinese Medicine , Beijing , China.
authors: Juan
authors: J
authors: Wang
authors: a Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine , Beijing , China.|b School of Chinese Materia Medica , Beijing University of Chinese Medicine , Beijing , China.
authors: Cong
authors: C
authors: Su
authors: a Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine , Beijing , China.
authors: Peng-Fei
authors: PF
authors: Tu
authors: a Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine , Beijing , China.
authors: She-Po
authors: SP
authors: Shi
mesh_terms: D029969:Angelica / Q000737:chemistry*; D000818:Animals; D004353:Drug Evaluation, Preclinical / Q000379:methods; D011564:Furocoumarins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D008070:Lipopolysaccharides / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000378:metabolism; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D000067996:RAW 264.7 Cells / Q000187:drug effects
chemical_list: D011564:Furocoumarins; D008070:Lipopolysaccharides; C000619297:dahuribiethrin H; C000619296:dahurinol A; D009569:Nitric Oxide
keywords: Angelica dahurica; anti-inflammatory; coumarin; dimeric furanocoumarin; nitric oxide production