title: Outcome differences between children and adolescents and young adults with non-Hodgkin lymphoma following stem cell transplantation.
abstract: Several studies of patients with acute lymphoblastic leukemia and acute myeloid leukemia who received stem cell transplantation (SCT) have reported that adolescents and young adults (AYAs) experience higher transplant-related mortality than that in younger children. However, to the best of our knowledge, there have been no reports of a similar comparison of non-Hodgkin lymphoma (NHL) patients who received SCT. We analyzed 918 patients aged 30 years and younger who received their first stem cell transplantation for NHL. Of the allogeneic transplant patients, children and AYAs did not significantly differ in survival rate, event-free survival rate, relapse rate, or transplant-related mortality. However, 5-year transplant-related mortality after autologous transplantation was significantly higher in children than in AYAs (5.1% in children vs. 0.8% in AYAs, P = 0.0043). The cause of transplant-related death in three of four children was interstitial pneumonitis. In NHL patients, transplantation results in AYAs were not inferior than those in children.
authors: Department of Pediatrics, Sapporo Hokuyu Hospital, Higashi-Sapporo 6-6, Shiroishiku, Sapporo, Hokkaido, 003-0006, Japan. r-koba@jacls.jp.
authors: Ryoji
authors: R
authors: Kobayashi
authors: Department of Pediatrics, Yamagata University School of Medicine, Yamagata, Japan.
authors: Tetsuo
authors: T
authors: Mitsui
authors: Department of Pediatrics, Hiroshima Red Cross Hospital and Atomic-bomb Survivors Hospital, Hiroshima, Japan.
authors: Naoto
authors: N
authors: Fujita
authors: Children's Cancer Center, National Center for Child Health and Development, Tokyo, Japan.
authors: Tomoo
authors: T
authors: Osumi
authors: Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors: Tomohiro
authors: T
authors: Aoki
authors: Department of Hematology and Oncology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
authors: Kazunari
authors: K
authors: Aoki
authors: Shimane University Hospital Cancer Center, Oncology/Hematology, Izumo, Japan.
authors: Ritsuro
authors: R
authors: Suzuki
authors: Division of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan.
authors: Takahiro
authors: T
authors: Fukuda
authors: Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors: Toshihiro
authors: T
authors: Miyamoto
authors: Department of Hematology and Oncology, Children's Medical Center, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan.
authors: Koji
authors: K
authors: Kato
authors: Hematology, Osaka City University Hospital, Osaka, Japan.
authors: Hirohisa
authors: H
authors: Nakamae
authors: Division of Hemato-oncology/Regenerative Medicine, Kanagawa Children's Medical Center, Yokohama, Japan.
authors: Hiroaki
authors: H
authors: Goto
authors: Department of Hematology, Hamanomachi Hospital, Fukuoka, Japan.
authors: Tetsuya
authors: T
authors: Eto
authors: Department of Hematology/Oncology, Osaka Medical Center and Research Institute for Maternal and Child Health, Osaka, Japan.
authors: Masami
authors: M
authors: Inoue
authors: Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
authors: Takehiko
authors: T
authors: Mori
authors: Department of Pediatrics, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
authors: Kiminori
authors: K
authors: Terui
authors: Department of Hematology/Oncology, Tokai University School of Medicine, Isehara, Japan.
authors: Masahito
authors: M
authors: Onizuka
authors: Department of Hematology/Oncology, Saitama Children's Medical Center, Saitama, Japan.
authors: Katsuyoshi
authors: K
authors: Koh
authors: Department of Pediatrics, Kyushu University Hospital, Fukuoka, Japan.
authors: Yuhki
authors: Y
authors: Koga
authors: Department of Hematology and Oncology, Hiroshima University Hospital, Hiroshima, Japan.
authors: Tatsuo
authors: T
authors: Ichinohe
authors: Department of Hematology/Oncology, Osaka Medical Center and Research Institute for Maternal and Child Health, Osaka, Japan.
authors: Akihisa
authors: A
authors: Sawada
authors: Japanese Data Center for Hematopoietic Cell Transplantation, Nagoya, Japan.
authors: Yoshiko
authors: Y
authors: Atsuta
authors: Shimane University Hospital Cancer Center, Oncology/Hematology, Izumo, Japan.
authors: Junji
authors: J
authors: Suzumiya
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D064591:Allografts; D064592:Autografts; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008228:Lymphoma, Non-Hodgkin / Q000150:complications / Q000401:mortality / Q000628:therapy*; D008297:Male; D011014:Pneumonia / Q000209:etiology; D033581:Stem Cell Transplantation / Q000009:adverse effects / Q000379:methods / Q000401:mortality*; D015996:Survival Rate; D055815:Young Adult
keywords: AYA; Non-Hodgkin lymphoma; Stem cell transplantation