title: Amphetamine and derivatives in natural weight loss pills and dietary supplements by capillary electrophoresis-tandem mass spectrometry.
abstract: A capillary electrophoresis-tandem mass spectrometry (CE-MS/MS) method for amphetamine (AM), phentermine (PTM), methamphetamine (MAM), methylenedioxyamphetamine (MDA), methylenedioxymethamphetamine (MDMA), and methylenedioxyethylamphetamine (MDEA) in commercial samples of homeopathic and phytotherapic medicines and dietary supplements is presented. The samples were submitted to a modified QuEChERS extraction procedure (at apparent pH 13) followed by electrophoretic separation in 0.1molL-1formic acid electrolyte (pH 2.4) and detection by ESI-MS/MS. A polyvinyl alcohol coated capillary was employed to prevent the adsorption of the analytes to the capillary wall. The limits of detection and quantitation were from 0.02 to 0.06μgL-1and from 0.06 to 0.21μgL-1, respectively, with recovery ranging from 85 to 123% and the standard deviations were not greater than 6.1%. In addition, the separation occurs in less than six minutes.
authors: Department of Fundamental Chemistry, Institute of Chemistry, University of São Paulo, Av. Prof. Lineu Prestes, 748, CEP 05508-000 São Paulo, SP, Brazil. Electronic address: vagnerbs@ufpa.br.
authors: Vagner Bezerra
authors: VB
authors: Dos Santos
authors: Agilent Technologies, Alameda Araguaia, 1142, CEP 06455-000 Barueri, SP, Brazil. Electronic address: daniel@agilent.com.
authors: Daniela
authors: D
authors: Daniel
authors: Bishop's University, Sherbrooke, Canada. Electronic address: MSINGH13@ubishops.ca.
authors: Melina
authors: M
authors: Singh
authors: Department of Fundamental Chemistry, Institute of Chemistry, University of São Paulo, Av. Prof. Lineu Prestes, 748, CEP 05508-000 São Paulo, SP, Brazil. Electronic address: claudemi@iq.usp.br.
authors: Claudimir Lucio
authors: CL
authors: do Lago
mesh_terms: D000661:Amphetamine / Q000032:analysis*; D019440:Anti-Obesity Agents / Q000032:analysis*; D001688:Biological Products / Q000032:analysis*; D000697:Central Nervous System Stimulants / Q000032:analysis*; D019587:Dietary Supplements / Q000032:analysis*; D019075:Electrophoresis, Capillary / Q000379:methods*; D057230:Limit of Detection; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods; D053719:Tandem Mass Spectrometry / Q000379:methods*
chemical_list: D019440:Anti-Obesity Agents; D001688:Biological Products; D000697:Central Nervous System Stimulants; D000661:Amphetamine
keywords: Amphetamine (PubChem CID 3007); Amphetamine derivatives; Amphetamines; Capillary electrophoresis; Illegal drugs; Methamphetamine (PubChem CID 10836); Methylenedioxyamphetamine (PubChem CID 297310); Methylenedioxyethylamphetamine (PubChem CID 3057998); Methylenedioxymethamphetamine (PubChem CID 1615); Natural weight loss pills; Phentermine (PubChem CID 4771); Tandem mass spectrometry; β-methylphenylethylamine (PubChem CID 11398)