title: Biomarker and competing endogenous RNA potential of tumor-specific long noncoding RNA in chromophobe renal cell carcinoma.
abstract: BACKGROUND
  Accumulating evidence suggests long noncoding RNAs (lncRNAs) play important roles in the initiation and progression of cancers. However, their functions in chromophobe renal cell carcinoma (chRCC) are not fully understood.
  
  
  METHODS
  We analyzed the expression profiles of lncRNA, microRNA, and protein-coding RNA, along with the clinical information of 59 primary chRCC patients collected from The Cancer Genome Atlas database to identify lncRNA biomarkers for prognosis. We also constructed an lncRNA-microRNA-mRNA coexpression network (competitive endogenous RNAs network) by bioinformational approach.
  
  
  RESULTS
  One hundred and forty-two lncRNAs were found to be differentially expressed between the cancer and normal tissues (fold change ≥1.5,P<0.001). Among them, 12 lncRNAs were also differentially expressed with the corresponding clinical characteristics (fold change ≥1.5,P<0.01). Besides, 7 lncRNAs (COL18A1-AS, BRE-AS1, SNHG7, TMEM51-AS1, C21orf62-AS1, LINC00336, and LINC00882) were identified to be significantly correlated with overall survival (log-rankP<0.05). A competitive endogenous RNA network in chRCC containing 16 lncRNAs, 18 miRNAs, and 168 protein-coding RNAs was constructed.
  
  
  CONCLUSIONS
  Our results identified specific lncRNAs associated with chRCC progression and prognosis, and presented competing endogenous RNA potential of lncRNAs in the tumor.
authors: Department of Pathogenobiology; Department of Cell Biology, College of Basic Medical Sciences, Jilin University, Changchun, People's Republic of China.
authors: Hai-Tao
authors: HT
authors: He
authors: Department of Pathogenobiology.
authors: Mu
authors: M
authors: Xu
authors: Department of Pathogenobiology.
authors: Ye
authors: Y
authors: Kuang
authors: Department of Pathogenobiology.
authors: Xiao-Yun
authors: XY
authors: Han
authors: Department of Pathogenobiology.
authors: Ming-Qi
authors: MQ
authors: Wang
authors: Department of Pathogenobiology.
authors: Qing
authors: Q
authors: Yang
keywords: biomarker; chromophobe renal cell carcinoma; competing endogenous RNA network; long noncoding RNA