title: Glycolipid substrates for ABC transporters required for the assembly of bacterial cell-envelope and cell-surface glycoconjugates.
abstract: Glycoconjugates, molecules that contain sugar components, are major components of the cell envelopes of bacteria and cover much of their exposed surfaces. These molecules are involved in interactions with the surrounding environment and, in pathogens, play critical roles in the interplay with the host immune system. Despite the remarkable diversity in glycoconjugate structures, most are assembled by glycosyltransferases that act on lipid acceptors at the cytosolic membrane. The resulting glycolipids are then transported to the cell surface in processes that frequently begin with ATP-binding cassette transporters. This review summarizes current understanding of the structure and biosynthesis of glycolipid substrates and the structure and functions of their transporters. This article is part of a Special Issue entitled: Bacterial Lipids edited by Russell E. Bishop.
authors: Department of Molecular and Cellular Biology, University of Guelph, Guelph, Ontario N1G2W1, Canada.
authors: Sean D
authors: SD
authors: Liston
authors: Department of Molecular and Cellular Biology, University of Guelph, Guelph, Ontario N1G2W1, Canada.
authors: Evan
authors: E
authors: Mann
authors: Department of Molecular and Cellular Biology, University of Guelph, Guelph, Ontario N1G2W1, Canada. Electronic address: cwhitfie@uoguelph.ca.
authors: Chris
authors: C
authors: Whitfield
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000737:chemistry / Q000378:metabolism*; D001419:Bacteria / Q000378:metabolism*; D001426:Bacterial Proteins / Q000737:chemistry / Q000378:metabolism*; D001692:Biological Transport; D002473:Cell Wall / Q000378:metabolism*; D006017:Glycolipids / Q000096:biosynthesis* / Q000737:chemistry; D050155:Lipogenesis; D008958:Models, Molecular; D011135:Polysaccharides, Bacterial / Q000737:chemistry / Q000378:metabolism*; D011487:Protein Conformation; D013329:Structure-Activity Relationship
chemical_list: D018528:ATP-Binding Cassette Transporters; D001426:Bacterial Proteins; D006017:Glycolipids; D011135:Polysaccharides, Bacterial
keywords: ABC transport; Bacteria; Cell surface; Export; Glycoconjugate; Glycolipid