title: Epidemiology and predictors of recurrence of Marjolin's ulcer: experience from Mansoura Universityxs.
abstract: INTRODUCTION Marjolin's ulcer (MU) is an uncommon malignancy occurring on top of old scars. Once thought to be more common in Caucasians, is now detected increasingly in Africa. METHODS This was a retrospective study of patients with MU attending a tertiary centre within Mansoura University (Egypt) from 2004 to 2015. An institutional-based registry of skin and soft-tissue malignancies in this period revealed 560 cases, from which there were 26 cases of MU. RESULTS The most common underlying cause of MU was burns (92% of patients), followed by trauma. A predilection towards males was detected. The latent period was 4-70 (median, 25) years. Recurrence occurred in 12 cases, with multiple recurrences occurring in 5 cases. MU recurrence was noted as early as 3 months and as late as 25 years after surgery. CONCLUSIONS Young patients with MU are at higher risk of recurrence and should be followed up closely. A thorough search for nodal metastasis (especially in those with high-grade tumours) should be done. Wide local excision and leaving wounds to heal by secondary intention seems to be a viable treatment option.
authors: Mansoura University , Egyptx.
authors: I H
authors: IH
authors: Metwally
authors: Mansoura University , Egyptx.
authors: A
authors: A
authors: Roshdy
authors: Mansoura University , Egyptx.
authors: S S
authors: SS
authors: Saleh
authors: Mansoura University , Egyptx.
authors: M
authors: M
authors: Ezzat
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D002056:Burns / Q000453:epidemiology*; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology* / Q000601:surgery; D002921:Cicatrix / Q000453:epidemiology*; D004534:Egypt / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology*; D012189:Retrospective Studies; D012307:Risk Factors; D017678:Sex Distribution; D012878:Skin Neoplasms / Q000453:epidemiology* / Q000601:surgery; D055815:Young Adult
keywords: Burn; Carcinoma; Marjolin’s ulcer; Scar; Skin cancer