title: Use of a single xenon flash lamp for photoacoustic computed tomography of multiple-centimeter-thick biological tissue ex vivo and a whole mouse body in vivo.
abstract: While lasers have been commonly used as illumination sources in photoacoustic (PA) imaging, their high purchase and maintenance costs, as well as their bulkiness, have hindered the rapid clinical dissemination of PA imaging. With this in mind, we explore an alternative illumination source for PA tomography—a xenon flash lamp with high pulse energy and a microsecond pulse width. We demonstrate that, by using a single xenon flash lamp, we can image both a black latex cord placed in chicken breast tissue at a depth of up to 3.5 cm ex vivo and an entire mouse body in vivo. Our findings indicate that the xenon flash lamp, producing optical illumination that is safe for humans, can be potentially applied to human tissue imaging.
authors: Washington University in St. Louis, Optical Imaging Laboratory, Department of Biomedical Engineering, One Brookings Drive, Saint Louis, Missouri 63130, United States.
authors: Terence T W
authors: TT
authors: Wong
authors: Washington University in St. Louis, Optical Imaging Laboratory, Department of Biomedical Engineering, One Brookings Drive, Saint Louis, Missouri 63130, United States.
authors: Yong
authors: Y
authors: Zhou
authors: Washington University in St. Louis, Optical Imaging Laboratory, Department of Biomedical Engineering, One Brookings Drive, Saint Louis, Missouri 63130, United States.
authors: Alejandro
authors: A
authors: Garcia-Uribe
authors: Washington University in St. Louis, Optical Imaging Laboratory, Department of Biomedical Engineering, One Brookings Drive, Saint Louis, Missouri 63130, United States.
authors: Lei
authors: L
authors: Li
authors: Washington University in St. Louis, Optical Imaging Laboratory, Department of Biomedical Engineering, One Brookings Drive, Saint Louis, Missouri 63130, United States.
authors: Konstantin
authors: K
authors: Maslov
authors: Washington University in St. Louis, Optical Imaging Laboratory, Department of Biomedical Engineering, One Brookings Drive, Saint Louis, Missouri 63130, United States.
authors: Li
authors: L
authors: Lin
authors: Washington University in St. Louis, Optical Imaging Laboratory, Department of Biomedical Engineering, One Brookings Drive, Saint Louis, Missouri 63130, United States.
authors: Lihong V
authors: LV
authors: Wang
mesh_terms: D000818:Animals; D003952:Diagnostic Imaging / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D007834:Lasers; D051379:Mice; D061088:Photoacoustic Techniques; D013057:Spectrum Analysis; D014057:Tomography, X-Ray Computed / Q000295:instrumentation*; D051598:Whole Body Imaging / Q000295:instrumentation / Q000379:methods*; D014978:Xenon
chemical_list: D014978:Xenon