title: Environmental Induction of Neurodevelopmental Disorders.
abstract: Chemical exposures, pre- and neonatal infections, psychosocial stress, and the cross-generational cultural and epigenetic impacts of these and other toxicants become an integrated, sometimes synergistic, signal that can overwhelm essential neurodevelopmental regulation. We characterize that dynamic through statistical models based on the asymptotic limit theorems of control and information theories. Schizophrenia and autism emerge as two different 'phases' of pathological neurodevelopmental 'condensations' that impair the dynamic, shifting global workspace of normal mental function.
authors: Division of Epidemiology, The New York State Psychiatric Institute, New York, NY, USA. Wallace@nyspi.columbia.edu.
authors: Rodrick
authors: R
authors: Wallace
mesh_terms: D000067877:Autism Spectrum Disorder / Q000209:etiology; D004781:Environmental Exposure / Q000009:adverse effects*; D006801:Humans; D007257:Information Theory; D055641:Mathematical Concepts; D008928:Mitochondria / Q000378:metabolism; D008959:Models, Neurological; D008960:Models, Psychological; D015233:Models, Statistical; D065886:Neurodevelopmental Disorders / Q000209:etiology*; D012307:Risk Factors; D012559:Schizophrenia / Q000209:etiology
keywords: Autism; Control theory; Data rate theorem; Information theory; Mitochondrial free energy; Phase transition; Rate–distortion theorem; Schizophrenia