title: Formyl Peptide Receptor 2 Is Involved in Cardiac Repair After Myocardial Infarction Through Mobilization of Circulating Angiogenic Cells.
abstract: Increasing evidence suggests that circulating angiogenic cells (CACs) promote repair of ischemic tissues. Activation of formyl peptide receptor 2 (Fpr2) has been reported to stimulate repair of ischemic heart. This study was conducted to investigate the role of Fpr2 on CAC mobilization and cardiac protection in myocardial infarction (MI). WKYMVm, a strong agonist for Fpr2, was administered in a murine model of acute MI, and mobilization of CACs including endothelial progenitor cells (CD34+Flk1+or Sca1+Flk1+cells) in peripheral blood was monitored. CAC mobilization by daily injection of WKYMVm for the first 4 days after MI was as efficient as granulocyte colony-stimulating factor and provided myocardial protection from apoptosis with increased vascular density and preservation of cardiac function. Transplantation of bone marrow (BM) from green fluorescent protein mice showed that BM-derived cells homed to ischemic heart after WKYMVm treatment and contributed to tissue protection. Transplantation of BM from Fpr2 knockout mice showed that Fpr2 in BM cells is critical in mediation of WKYMVm-stimulated myocardial protection and neovascularization after MI. These results suggest that activation of Fpr2 in BM after WKYMVm treatment provides cardiac protection through mobilization of CACs after MI, which may lead to the development of a new clinical protocol for treating patients with ischemic heart conditions. Stem Cells 2017;35:654-665.
authors: Department of Physiology, School of Medicine, Pusan National University, Yangsan, Republic of Korea.
authors: Soon Chul
authors: SC
authors: Heo
authors: Department of Physiology, School of Medicine, Pusan National University, Yangsan, Republic of Korea.
authors: Yang Woo
authors: YW
authors: Kwon
authors: Department of Physiology, School of Medicine, Pusan National University, Yangsan, Republic of Korea.
authors: Il Ho
authors: IH
authors: Jang
authors: Department of Physiology, School of Medicine, Pusan National University, Yangsan, Republic of Korea.
authors: Geun Ok
authors: GO
authors: Jeong
authors: Department of Physiology, School of Medicine, Pusan National University, Yangsan, Republic of Korea.
authors: Tae Wook
authors: TW
authors: Lee
authors: Department of Physiology, School of Medicine, Pusan National University, Yangsan, Republic of Korea.
authors: Jung Won
authors: JW
authors: Yoon
authors: Division of Hematology-Oncology, Department of Internal Medicine, School of Medicine, Medical Research Institute, Pusan National University Hospital, Busan, Republic of Korea.
authors: Ho Jin
authors: HJ
authors: Shin
authors: Department of Cardiology, Chonnam National University Hospital, Gwangju, Republic of Korea.
authors: Hae Chang
authors: HC
authors: Jeong
authors: Department of Cardiology, Chonnam National University Hospital, Gwangju, Republic of Korea.
authors: Youngkeun
authors: Y
authors: Ahn
authors: Department of Physiology, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, Busan, Republic of Korea.
authors: Tae Hee
authors: TH
authors: Ko
authors: Functional Genomics Research Center, KRIBB, Daejeon, Republic of Korea.
authors: Sang Chul
authors: SC
authors: Lee
authors: Department of Physiology, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, Busan, Republic of Korea.
authors: Jin
authors: J
authors: Han
authors: Department of Physiology, School of Medicine, Pusan National University, Yangsan, Republic of Korea.|Research Institute of Convergence Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea.
authors: Jae Ho
authors: JH
authors: Kim
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells / Q000187:drug effects / Q000378:metabolism; D002316:Cardiotonic Agents / Q000494:pharmacology; D066026:Endothelial Progenitor Cells / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism; D006334:Heart Function Tests; D008297:Male; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009203:Myocardial Infarction / Q000378:metabolism* / Q000473:pathology* / Q000503:physiopathology; D018919:Neovascularization, Physiologic / Q000187:drug effects; D009842:Oligopeptides / Q000494:pharmacology; D044042:Receptors, Formyl Peptide / Q000378:metabolism*; D012038:Regeneration / Q000187:drug effects
chemical_list: D002316:Cardiotonic Agents; D009842:Oligopeptides; D044042:Receptors, Formyl Peptide; C113617:Trp-Lys-Tyr-Met-Val-Met
keywords: Circulating angiogenic cell; Formyl peptide receptor; Mobilization; Myocardial infarction; Neovascularization; WKYMVm