title: Dynamic changes of the intraocular pressure and the pressure of cerebrospinal fluid in nonglaucomatous neurological patients.
abstract: OBJECTIVE
  To describe the dynamic changes of the intraocular pressure (IOP) and intracranial pressure (ICP) with normal or pathological values (intracranial hypertension) in nonglaucomatous neurological patients during lumbar punction (LP).
  
  
  METHODS
  Case-control study, prospective measurement of tonometry in both groups referred for LP. Intraocular pressure, ICP and translaminar pressure difference (TPD) were compared pre- and post-LP.
  
  
  RESULTS
  Thirty-six patients (72 eyes) with mean age of 38.5 (16-64) years and BMI of 26.81 kg/m2were analysed. The initial mean ICP was 12.81 (± 6.6) mmHg. The mean TPD before and after the LP was 1.48 mmHg and 0.65 mmHg, respectively. The mean IOP of both eyes decreased to 0.8 mmHg post-LP in patients with pathological ICP (p = 0.0193) and normal ICP (p = 0.006).
  
  
  CONCLUSIONS
  We found a statistically significant decrease of the IOP post-LP compared to the pre-LP in both groups, being higher in patients with pathological ICP. There were no significant differences of the IOP in patients with normal versus pathological ICP pre-LP/post-LP; neither was found a correlation between ICP and IOP.
authors: Neuro-Ophthalmology Department, National Institute of Neurology and Neurosurgery, Mexico City, Mexico.
authors: Pedro Iván
authors: PI
authors: González-Camarena
authors: Clinical Research Department, National Institute of Neurology and Neurosurgery, Mexico City, Mexico.|ABC Medical Center at Santa Fe, Mexico City, Mexico.
authors: Daniel
authors: D
authors: San-Juan
authors: Neuro-Ophthalmology Department, National Institute of Neurology and Neurosurgery, Mexico City, Mexico.
authors: Irene
authors: I
authors: González-Olhovich
authors: Faculty of Medicine, University of Colima, Colima, México.
authors: David
authors: D
authors: Rodríguez-Arévalo
authors: Neuro-Ophthalmology Department, National Institute of Neurology and Neurosurgery, Mexico City, Mexico.
authors: David
authors: D
authors: Lozano-Elizondo
authors: Institute of Clinical Neuroscience and Medical Psychology, University Hospital Düsseldorf, Düsseldorf, Germany.
authors: Carlos
authors: C
authors: Trenado
authors: Comprehensive Epilepsy Center of Long Island, St. Charles Hospital, Port Jefferson, NY, USA.
authors: David J
authors: DJ
authors: Anschel
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D019586:Intracranial Hypertension / Q000503:physiopathology*; D007427:Intracranial Pressure / Q000502:physiology*; D007429:Intraocular Pressure / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013997:Time Factors; D055815:Young Adult
keywords: cerebrospinal fluid pressure; intracranial pressure; intraocular pressure; translaminar pressure difference