title: Arterial Calcium Stimulation with Hepatic Venous Sampling in the Localization Diagnosis of Endogenous Hyperinsulinism.
abstract: Objective. The aim of this study was to assess the utility of arterial calcium stimulation with hepatic venous sampling (ASVS) in the localization diagnosis of endogenous hyperinsulinism.Patients and Methods. A retrospective descriptive study was performed including patients with endogenous hyperinsulinism who underwent ASVS. The histopathological diagnosis in patients who underwent a surgical procedure was used as the reference for the statistical study of the accuracy of this technique.Results. 30 patients were included with endogenous hyperinsulinism and nonconclusive imaging diagnosis was included. ASVS was performed in all cases. Surgery was performed in 20 cases. Insulinoma was removed in 19 patients; the location of all cases was detected in the ASVS. All cases of endogenous hyperinsulinism had a positive result for the ASVS, with this association being statistically significant (χ2= 15.771;p< 0.001). A good and statistically significant agreement was obtained between histopathologic diagnosis and ASVS results (K= 0.518,p< 0.001).Conclusions. ASVS is a useful procedure in the localization diagnosis of endogenous hyperinsulinism undetected by other imaging tests. This technique allows the localization of intrapancreatic insulinomas and represents useful tool for the diagnosis and surgical management of these tumors.
authors: Maimonides Institute for Biomedical Research of Cordoba (IMIBIC), Córdoba, Spain; Endocrinology and Nutrition Service, Reina Sofia University Hospital, Córdoba, Spain.
authors: Paloma
authors: P
authors: Moreno-Moreno
authors: Maimonides Institute for Biomedical Research of Cordoba (IMIBIC), Córdoba, Spain; Endocrinology and Nutrition Service, Reina Sofia University Hospital, Córdoba, Spain.
authors: María Rosa
authors: MR
authors: Alhambra-Expósito
authors: Maimonides Institute for Biomedical Research of Cordoba (IMIBIC), Córdoba, Spain; Endocrinology and Nutrition Service, Reina Sofia University Hospital, Córdoba, Spain.
authors: Aura Dulcinea
authors: 0000-0003-1437-9878
authors: AD
authors: Herrera-Martínez
authors: Endocrinology and Nutrition Service, Reina Sofia University Hospital, Córdoba, Spain.
authors: Rafel
authors: R
authors: Palomares-Ortega
authors: Radiology Department, Reina Sofia University Hospital, Córdoba, Spain.
authors: Luis
authors: L
authors: Zurera-Tendero
authors: Radiology Department, Reina Sofia University Hospital, Córdoba, Spain.
authors: Juan José
authors: JJ
authors: Espejo Herrero
authors: Maimonides Institute for Biomedical Research of Cordoba (IMIBIC), Córdoba, Spain; Endocrinology and Nutrition Service, Reina Sofia University Hospital, Córdoba, Spain.
authors: María Angeles
authors: MA
authors: Gálvez-Moreno