title: TREMs in Alzheimer's disease: Genetic and clinical investigations.
abstract: Triggering receptor expressed on myeloid cells (TREMs) receptors constitute a family modulators in human innate immunity system that encode by a gene cluster. Rare variants in TREM2 were reported to be associated with significant Alzheimer's disease (AD) risk. However, inconsistent results were also reported in some studies of Non-European descents. Recently, the other TREM family members are also considered to involve in AD and cerebrospinal fluid (CSF) soluble form of TREM2 (sTREM2) levels has also been associated with respond to progression of disease. In this review, we converged the data of genetic and clinical investigations to identify the clearer role of TREMs in AD. Here, comprehensively analyze of multidisciplinary fields highlights the contribution of TREMs locus to AD development.
authors: Zhongshan Hospital, Xiamen University, Xiamen, Fujian, China. Electronic address: drchengjia@163.com.
authors: Jia
authors: J
authors: Cheng
authors: Zhongshan Hospital, Xiamen University, Xiamen, Fujian, China.
authors: XiaoFeng
authors: X
authors: Guo
authors: Zhongshan Hospital, Xiamen University, Xiamen, Fujian, China.
authors: Tian
authors: T
authors: Zhang
authors: Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Medical College, Xiamen University, Xiamen, Fujian, China.
authors: Li
authors: L
authors: Zhong
authors: Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Medical College, Xiamen University, Xiamen, Fujian, China; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
authors: GuoJun
authors: G
authors: Bu
authors: Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Medical College, Xiamen University, Xiamen, Fujian, China.
authors: XiaoFen
authors: X
authors: Chen
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008562:Membrane Glycoproteins / Q000235:genetics* / Q000378:metabolism; D022423:Myeloid Cells / Q000378:metabolism / Q000473:pathology; D011971:Receptors, Immunologic / Q000235:genetics* / Q000378:metabolism
chemical_list: D008562:Membrane Glycoproteins; D011971:Receptors, Immunologic; C498715:TREM2 protein, human
keywords: Alzheimer's disease; Biomarker; Epigenetic; TREM2; TREML; sTREM2