title: Ferritin Level Is Positively Associated with Chronic Kidney Disease in Korean Men, Based on the 2010-2012 Korean National Health and Nutrition Examination Survey.
abstract: (1) Background: Oxidative stress and inflammation are associated with higher risk of chronic kidney disease (CKD). Serum ferritin concentrations correlate with total iron levels and systemic inflammation. (2) Methods: This study was cross-sectionally designed, based on the 2010-2012 Korean National Health and Nutrition Examination Survey (KNHANES). According to ferritin values, 13,462 participants (6082 men and 7380 women) were categorized into the normal- and high-ferritin groups (cut-off points: 200 ng/mL in men, 150 ng/mL in women). (3) Results: The mean ages of men and women were 44.5 and 48.4 years, respectively. The percentage of participants categorized into the high-ferritin group was 15.1% for men and 3.6% for women. The estimated glomerular filtration rate levels in the normal- and high-ferritin groups were 93.2 and 93.8 mL/min/1.73 m² for men and 97.1 and 87.7 mL/min/1.73 m² for women, respectively. The prevalence of CKD in the normal- and high-ferritin groups was 2.6% and 3.9% for men and 3.2% and 8.1% for women, respectively. Compared with the normal-ferritin group, the odds ratios (95% confidence intervals) for CKD of the high-ferritin group were 1.573 (1.014-2.441) in men and 1.061 (0.381-2.955) in women, after adjustments for age and other covariates. (4) Conclusions: High ferritin levels were associated with a higher risk of CKD in men but not in women.
authors: Department of Family Medicine, College of Medicine, Chungbuk National University, Chungbuk 28644, Korea. kanght0818@gmail.com.
authors: Hee-Taik
authors: HT
authors: Kang
authors: Department of Family Medicine, Severance Hospital, Yonsei University, Seoul 03722, Korea. yohan@yuhs.ac.
authors: John A
authors: JA
authors: Linton
authors: Division of Nephrology, Department of Internal Medicine, College of Medicine, Chungbuk National University, Chungbuk 28644, Korea. kwon@chungbuk.ac.kr.
authors: Soon Kil
authors: SK
authors: Kwon
authors: Department of Family Medicine, Yongin Severance Hospital, Yonsei University, Yongin 17046, Korea. bjpark96@yuhs.ac.
authors: Byoung-Jin
authors: BJ
authors: Park
authors: Department of Food Science and Biotechnology, College of Life Science, CHA University, Seongnam-si 13488, Korea. foodguy@cha.ac.kr.
authors: Jong Hun
authors: JH
authors: Lee
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D005260:Female; D005293:Ferritins / Q000097:blood*; D006801:Humans; D007249:Inflammation / Q000097:blood* / Q000150:complications; D008297:Male; D008875:Middle Aged; D009749:Nutrition Surveys; D016017:Odds Ratio; D018384:Oxidative Stress; D015995:Prevalence; D051436:Renal Insufficiency, Chronic / Q000097:blood* / Q000453:epidemiology; D056910:Republic of Korea / Q000453:epidemiology
chemical_list: D005293:Ferritins
keywords: chronic kidney disease; ferritin; inflammation; iron; oxidative stress