title: Photothermal and mechanical stimulation of cells via dualfunctional nanohybrids.
abstract: Stimulating cells by light is an attractive technology to investigate cellular function and deliver innovative cell-based therapy. However, current techniques generally use poorly biopermeable light, which prevents broad applicability. Here, we show that a new type of composite nanomaterial, synthesized from multi-walled carbon nanotubes, magnetic iron nanoparticles, and polyglycerol, enables photothermal and mechanical control of Ca2+influx into cells overexpressing transient receptor potential vanilloid type-2. The nanohybrid is simply operated by application of highly biotransparent near-infrared light and a magnetic field. The technology may revolutionize remote control of cellular function.
authors: Nanomaterial Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Central 5, 1-1-1 Higashi, Tsukuba 305-8565, Japan.
authors: Svetlana A
authors: SA
authors: Chechetka
authors: Motomichi
authors: M
authors: Doi
authors: Benoit P
authors: BP
authors: Pichon
authors: Sylvie
authors: S
authors: Bégin-Colin
authors: Eijiro
authors: E
authors: Miyako
mesh_terms: D007259:Infrared Rays; D008280:Magnetics; D058185:Magnetite Nanoparticles; D049329:Nanostructures; D037742:Nanotubes, Carbon
chemical_list: D058185:Magnetite Nanoparticles; D037742:Nanotubes, Carbon