title: Efficacy of PET-CT in the Diagnosis and Treatment of Recurrence After Esophageal Cancer Surgery.
abstract: Aim The present study aimed to retrospectively investigate the utility of positron-emission tomography with 2-deoxy-2-[fluorine-18]fluoro-D-glucose integrated with computed tomography (PET-CT) in regular follow-ups after esophageal cancer surgery.
  
  
  
  Clinical outcomes were retrospectively analyzed for 61 patients who were diagnosed with postoperative recurrence using PET-CT.
  
  
  
  A univariate analysis revealed that single recurrence, a low cytokeratin 19 fragment (CYFRA) value, chemoradiotherapy against recurrence, and recurrence over 6 months after surgery were significant prognostic factors. A low CYFRA level and single recurrence tended to be good prognostic factors in the multivariate analysis. The prognosis of cases with single recurrent tumor of size less than 10 mm was significantly better than those with tumors of 10 mm or more. PET-CT revealed small recurrent tumors, and contributed to the early detection of recurrence outside the body trunk.
  
  
  
  PET-CT contributes to the detection of single small recurrent tumors and those outside the body trunk. This follow-up method using PET-CT should be considered for patients after esophageal cancer surgery.
authors: Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.
authors: Michihiro
authors: M
authors: Kudou
authors: Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan shiozaki@koto.kpu-m.ac.jp.
authors: Atsushi
authors: A
authors: Shiozaki
authors: Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.
authors: Hitoshi
authors: H
authors: Fujiwara
authors: Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.
authors: Hirotaka
authors: H
authors: Konishi
authors: Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.
authors: Tomohiro
authors: T
authors: Arita
authors: Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.
authors: Toshiyuki
authors: T
authors: Kosuga
authors: Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.
authors: Ryo
authors: R
authors: Morimura
authors: Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.
authors: Yasutoshi
authors: Y
authors: Murayama
authors: Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.
authors: Shuhei
authors: S
authors: Komatsu
authors: Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.
authors: Yoshiaki
authors: Y
authors: Kuriu
authors: Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.
authors: Hisashi
authors: H
authors: Ikoma
authors: Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.
authors: Masayoshi
authors: M
authors: Nakanishi
authors: Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.
authors: Daisuke
authors: D
authors: Ichikawa
authors: Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.
authors: Kazuma
authors: K
authors: Okamoto
authors: Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.
authors: Eigo
authors: E
authors: Otsuji
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D004938:Esophageal Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000628:therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D049268:Positron-Emission Tomography; D011379:Prognosis; D014057:Tomography, X-Ray Computed; D055815:Young Adult
keywords: Esophageal cancer; PET-CT; post-operative follow-up