title: Discovery of Anticancer Agents of Diverse Natural Origin.
abstract: Recent progress is described in an ongoing collaborative multidisciplinary research project directed towards the purification, structural characterization, chemical modification, and biological evaluation of new potential natural product anticancer agents obtained from a diverse group of organisms, comprising tropical plants, aquatic and terrestrial cyanobacteria, and filamentous fungi. Information is provided on how these organisms are collected and processed. The types of bioassays are indicated in which initial extracts, chromatographic fractions, and purified isolated compounds of these acquisitions are tested. Several promising biologically active lead compounds from each major organism class investigated are described, and these may be seen to be representative of a very wide chemical diversity.
authors: College of Pharmacy, The Ohio State University, Columbus, OH, U.S.A. kinghorn.4@osu.edu.|Comprehensive Cancer Center, The Ohio State University, Columbus, OH, U.S.A.
authors: A Douglas
authors: AD
authors: Kinghorn
authors: College of Pharmacy, The Ohio State University, Columbus, OH, U.S.A.
authors: Esperanza J Carcache
authors: EJ
authors: DE Blanco
authors: Comprehensive Cancer Center, The Ohio State University, Columbus, OH, U.S.A.|College of Medicine, The Ohio State University, Columbus, OH, U.S.A.
authors: David M
authors: DM
authors: Lucas
authors: College of Pharmacy, The Ohio State University, Columbus, OH, U.S.A.
authors: H Liva
authors: HL
authors: Rakotondraibe
authors: College of Pharmacy, University of Illinois at Chicago, Chicago, IL, U.S.A.
authors: Jimmy
authors: J
authors: Orjala
authors: College of Pharmacy, University of Illinois at Chicago, Chicago, IL, U.S.A.|Field Museum of Natural History, Chicago, IL, U.S.A.
authors: D Doel
authors: DD
authors: Soejarto
authors: Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, NC, U.S.A.
authors: Nicholas H
authors: NH
authors: Oberlies
authors: Mycosynthetix, Inc., Hillsborough, NC, U.S.A.
authors: Cedric J
authors: CJ
authors: Pearce
authors: Research Triangle Institute, Research Triangle Park, NC, U.S.A.
authors: Mansukh C
authors: MC
authors: Wani
authors: Department of Biological Sciences, Columbia University, New York, NY, U.S.A.|Department of Chemistry, Columbia University, New York, NY, U.S.A.
authors: Brent R
authors: BR
authors: Stockwell
authors: College of Pharmacy, University of Illinois at Chicago, Chicago, IL, U.S.A.
authors: Joanna E
authors: JE
authors: Burdette
authors: School of Pharmacy, University of Wisconsin-Madison, Madison, WI, U.S.A.
authors: Steven M
authors: SM
authors: Swanson
authors: College of Pharmacy, The Ohio State University, Columbus, OH, U.S.A.
authors: James R
authors: JR
authors: Fuchs
authors: College of Pharmacy, The Ohio State University, Columbus, OH, U.S.A.|Comprehensive Cancer Center, The Ohio State University, Columbus, OH, U.S.A.
authors: Mitchell A
authors: MA
authors: Phelps
authors: Comprehensive Cancer Center, The Ohio State University, Columbus, OH, U.S.A.
authors: Lihui
authors: L
authors: Xu
authors: Comprehensive Cancer Center, The Ohio State University, Columbus, OH, U.S.A.|College of Medicine, The Ohio State University, Columbus, OH, U.S.A.
authors: Xiaoli
authors: X
authors: Zhang
authors: Eisai Inc., Andover, MA, U.S.A.
authors: Young Yongchun
authors: YY
authors: Shen
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001688:Biological Products / Q000627:therapeutic use*; D055808:Drug Discovery; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents; D001688:Biological Products
keywords: Natural products; cyanobacteria; fungi; potential anticancer activity; review; tropical plants