title: Averting the foul taste of pediatric medicines improves adherence and can be lifesaving - Pheburane®(sodium phenylbutyrate).
abstract: BACKGROUND
  Children's aversions to poor and mostly bitter tastes and their inability to swallow tablets and capsules are major challenges in pediatric medicine. Sodium phenylbutyrate (NaPB) is a lifesaving waste nitrogen, alternative to urea nitrogen, for individuals suffering from urea cycle disorders. A major issue in the use of NaPB is its highly foul taste, which often leads to children being unable to consume it, resulting in ineffective treatment, or alternatively, necessitating the application of the drug through a nasogastric tube or gastrostomy.
  
  
  METHODS
  This study reviews the published data on a novel formulation of NaPB, Pheburane®granules, which begin to release their NaPB after a lag time of ~10 seconds followed by a slow release over several minutes.
  
  
  RESULTS
  The taste-masked granule formulation of NaPB dramatically improves the acceptability of the drug by children and appears in initial studies to be both safe and effective.
  
  
  CONCLUSIONS
  While more studies are needed to substantiate and enrich these initial trials, the available data provide a telling example where masking the drug taste of medicine for children can sometimes be the difference between life and death.
authors: Department of Physiology and Pharmacology, The University of Western Ontario, London, ON, Canada.
authors: Gideon
authors: G
authors: Koren
authors: Department of Physiology and Pharmacology, The University of Western Ontario, London, ON, Canada.
authors: Michael J
authors: MJ
authors: Rieder
authors: Bar-Ilan University, Ramat Gan, Israel.
authors: Yona
authors: Y
authors: Amitai
keywords: Pheburane®; adherence; children; sodium phenylbutyrate; taste; urea cycle disorders