title: Opening the door to the development of novel Abl kinase inhibitors.
abstract: The discovery of the importance of kinase activity and its relationship to the emergence and proliferation of cancer cells, due to changes in normal physiology, opened a remarkable pathway for the treatment of chronic myelogenous leukemia through intense search of drug candidates. Six Abl kinase inhibitors have received the US FDA approval as chronic myelogenous leukemia treatment, and continuous efforts in obtaining new, more effective and selective molecules are being carried out. Herein we discuss the mechanisms of Abl inhibition, structural features and ligand/protein interactions that are important for the design of new Abl kinase inhibitors. This review provides a broad overview of binding mode predictions, through molecular docking, which can be an approach to discover novel Abl kinase inhibitors.
authors: Chemistry & Physics Department, Federal University of Espirito Santo, Campus de Alegre, CCENS, Alegre, ES, 29.500-000, Brazil.
authors: Pedro Alves
authors: PA
authors: Bezerra Morais
authors: Pharmaceutical Sciences Department, Federal University of Espirito Santo, Campus de Maruípe, CCS, Vitória, ES, 29.043-900, Brazil.
authors: Renata Dalmaschio
authors: RD
authors: Daltoé
authors: Pharmacy & Nutrition Department, Federal University of Espirito Santo, Campus de Alegre, CCENS, Alegre, ES, 29.500-000, Brazil.
authors: Heberth de
authors: H
authors: Paula
keywords: bio-organic chemistry; chronic myelogenous leukemia; computational chemistry and molecular modeling; drug design; drug development; molecular biology; oncological therapeutics; pharmacology; protein chemistry; structural biology