title: Molecular targeting of hypoxia in radiotherapy.
abstract: Hypoxia (low O2) is an essential microenvironmental driver of phenotypic diversity in human solid cancers. Hypoxic cancer cells hijack evolutionarily conserved, O2- sensitive pathways eliciting molecular adaptations that impact responses to radiotherapy, tumor recurrence and patient survival. In this review, we summarize the radiobiological, genetic, epigenetic and metabolic mechanisms orchestrating oncogenic responses to hypoxia. In addition, we outline emerging hypoxia- targeting strategies that hold promise for individualized cancer therapy in the context of radiotherapy and drug delivery.
authors: Princess Margaret Cancer Centre and The Campbell Family Institute for Cancer Research, University Health Network, Toronto, Ontario, Canada.
authors: Sergio
authors: S
authors: Rey
authors: Princess Margaret Cancer Centre and The Campbell Family Institute for Cancer Research, University Health Network, Toronto, Ontario, Canada.
authors: Luana
authors: L
authors: Schito
authors: Princess Margaret Cancer Centre and The Campbell Family Institute for Cancer Research, University Health Network, Toronto, Ontario, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada.
authors: Marianne
authors: M
authors: Koritzinsky
authors: Princess Margaret Cancer Centre and The Campbell Family Institute for Cancer Research, University Health Network, Toronto, Ontario, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada; Medical Biophysics, University of Toronto, Toronto, Ontario, Canada. Electronic address: bwouters@uhnresearch.ca.
authors: Bradly G
authors: BG
authors: Wouters
mesh_terms: D015687:Cell Hypoxia / Q000235:genetics / Q000528:radiation effects*; D044127:Epigenesis, Genetic; D006801:Humans; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology / Q000532:radiotherapy*; D010100:Oxygen / Q000378:metabolism*
chemical_list: D010100:Oxygen
keywords: Cancer Metabolism; Drug Delivery; HIF; Hypoxia; Hypoxia Tolerance; Ionizing Radiation; ROS; Radiosensitizers; Targeted Cancer Therapy; Tumor Microenvironment; UPR