title: Stent Thrombosis Patients with Hyporesponsiveness to Clopidogrel, Prasugrel, and Ticagrelor: A Case Series Using Short Thromboelastography.
abstract: Patients after percutaneous coronary intervention (PCI) with stent implantation and functional hyporesponsiveness to P2Y12inhibitors are at higher risk of ischaemic events, particularly stent thrombosis (ST). It is currently not routine practice to assess the functional response to these agents. However, concern over functional hyporesponsiveness to clopidogrel has led to widespread uptake of prasugrel and ticagrelor as the default P2Y12inhibitor after stent implantation in patients with acute coronary syndrome. Here we report, for the first time, 3 cases in which patients who have had ST exhibit hyporesponsiveness to clopidogrel, prasugrel, and ticagrelor.
authors: Wessex Cardiothoracic Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
authors: Bartosz
authors: 0000-0001-5252-0479
authors: B
authors: Olechowski
authors: Wessex Cardiothoracic Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
authors: Alexander
authors: 0000-0002-8287-9607
authors: A
authors: Ashby
authors: Wessex Cardiothoracic Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
authors: Nalyaka
authors: N
authors: Sambu
authors: Wessex Cardiothoracic Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
authors: Michael
authors: M
authors: Mahmoudi
authors: Wessex Cardiothoracic Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
authors: Nick
authors: N
authors: Curzen