title: Mutation rate analysis via parent-progeny sequencing of the perennial peach. II. No evidence for recombination-associated mutation.
abstract: Mutation rates and recombination rates vary between species and between regions within a genome. What are the determinants of these forms of variation? Prior evidence has suggested that the recombination might be mutagenic with an excess of new mutations in the vicinity of recombination break points. As it is conjectured that domesticated taxa have higher recombination rates than wild ones, we expect domesticated taxa to have raised mutation rates. Here, we use parent-offspring sequencing in domesticated and wild peach to ask (i) whether recombination is mutagenic, and (ii) whether domesticated peach has a higher recombination rate than wild peach. We find no evidence that domesticated peach has an increased recombination rate, nor an increased mutation rate near recombination events. If recombination is mutagenic in this taxa, the effect is too weak to be detected by our analysis. While an absence of recombination-associated mutation might explain an absence of a recombination-heterozygozity correlation in peach, we caution against such an interpretation.
authors: State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210023, People's Republic of China.
authors: Long
authors: 0000-0002-4922-8108
authors: L
authors: Wang
authors: State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210023, People's Republic of China.
authors: Yanchun
authors: Y
authors: Zhang
authors: State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210023, People's Republic of China.
authors: Chao
authors: C
authors: Qin
authors: State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210023, People's Republic of China.
authors: Dacheng
authors: 0000-0002-2327-0578
authors: D
authors: Tian
authors: State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210023, People's Republic of China sihaiyang@nju.edu.cn.
authors: Sihai
authors: 0000-0002-7862-6412
authors: S
authors: Yang
authors: The Milner Centre for Evolution, Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK bssldh@bath.ac.uk.
authors: Laurence D
authors: 0000-0002-1002-1054
authors: LD
authors: Hurst
mesh_terms: D018745:Genome, Plant; D009154:Mutation; D059645:Mutation Rate; D000068239:Prunus persica / Q000235:genetics*; D011995:Recombination, Genetic
keywords: crossover rate; domestication; mutation rate; peach