title: Utility of a Multiparametric Quantitative MRI Model That Assesses Myelin and Edema for Evaluating Plaques, Periplaque White Matter, and Normal-Appearing White Matter in Patients with Multiple Sclerosis: A Feasibility Study.
abstract: T1 and T2 values and proton density can now be quantified on the basis of a single MR acquisition. The myelin and edema in a voxel can also be estimated from these values. The purpose of this study was to evaluate a multiparametric quantitative MR imaging model that assesses myelin and edema for characterizing plaques, periplaque white matter, and normal-appearing white matter in patients with MS.
  
  
  
  We examined 3T quantitative MR imaging data from 21 patients with MS. The myelin partial volume, excess parenchymal water partial volume, the inverse of T1 and transverse T2 relaxation times (R1, R2), and proton density were compared among plaques, periplaque white matter, and normal-appearing white matter.
  
  
  
  All metrics differed significantly across the 3 groups (P< .001). Those in plaques differed most from those in normal-appearing white matter. The percentage changes of the metrics in plaques and periplaque white matter relative to normal-appearing white matter were significantly more different from zero for myelin partial volume (mean, -61.59 ± 20.28% [plaque relative to normal-appearing white matter], and mean, -10.51 ± 11.41% [periplaque white matter relative to normal-appearing white matter]), and excess parenchymal water partial volume (13.82 × 103± 49.47 × 103% and 51.33 × 102± 155.31 × 102%) than for R1 (-35.23 ± 13.93% and -6.08 ± 8.66%), R2 (-21.06 ± 11.39% and -4.79 ± 6.79%), and proton density (23.37 ± 10.30% and 3.37 ± 4.24%).
  
  
  
  Multiparametric quantitative MR imaging captures white matter damage in MS. Myelin partial volume and excess parenchymal water partial volume are more sensitive to the MS disease process than R1, R2, and proton density.
authors: From the Department of Radiology (A.H., A.K.), Graduate School of Medicine, University of Tokyo, Tokyo, Japan ahagiwara-tky@umin.ac.jp.|Departments of Radiology (A.H., M.H., M.Y.T., C.A., K.K.K., M.N., N.T., H.K., S.S., N.H., S.A.).
authors: A
authors: 0000-0001-5277-3249
authors: A
authors: Hagiwara
authors: Departments of Radiology (A.H., M.H., M.Y.T., C.A., K.K.K., M.N., N.T., H.K., S.S., N.H., S.A.).
authors: M
authors: 0000-0002-1791-8032
authors: M
authors: Hori
authors: Neurology (K.Y.), Juntendo University School of Medicine, Tokyo, Japan.
authors: K
authors: 0000-0002-0950-1093
authors: K
authors: Yokoyama
authors: Departments of Radiology (A.H., M.H., M.Y.T., C.A., K.K.K., M.N., N.T., H.K., S.S., N.H., S.A.).
authors: M Y
authors: 0000-0002-8187-0926
authors: MY
authors: Takemura
authors: Departments of Radiology (A.H., M.H., M.Y.T., C.A., K.K.K., M.N., N.T., H.K., S.S., N.H., S.A.).
authors: C
authors: 0000-0002-9339-6950
authors: C
authors: Andica
authors: Departments of Radiology (A.H., M.H., M.Y.T., C.A., K.K.K., M.N., N.T., H.K., S.S., N.H., S.A.).
authors: K K
authors: 0000-0001-5924-3283
authors: KK
authors: Kumamaru
authors: Departments of Radiology (A.H., M.H., M.Y.T., C.A., K.K.K., M.N., N.T., H.K., S.S., N.H., S.A.).
authors: M
authors: 0000-0002-6309-2403
authors: M
authors: Nakazawa
authors: Departments of Radiology (A.H., M.H., M.Y.T., C.A., K.K.K., M.N., N.T., H.K., S.S., N.H., S.A.).
authors: N
authors: 0000-0003-1506-6849
authors: N
authors: Takano
authors: Departments of Radiology (A.H., M.H., M.Y.T., C.A., K.K.K., M.N., N.T., H.K., S.S., N.H., S.A.).
authors: H
authors: 0000-0002-1942-9363
authors: H
authors: Kawasaki
authors: Departments of Radiology (A.H., M.H., M.Y.T., C.A., K.K.K., M.N., N.T., H.K., S.S., N.H., S.A.).
authors: S
authors: 0000-0001-5938-7690
authors: S
authors: Sato
authors: Departments of Radiology (A.H., M.H., M.Y.T., C.A., K.K.K., M.N., N.T., H.K., S.S., N.H., S.A.).
authors: N
authors: 0000-0001-8360-4034
authors: N
authors: Hamasaki
authors: From the Department of Radiology (A.H., A.K.), Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
authors: A
authors: 0000-0002-7141-2585
authors: A
authors: Kunimatsu
authors: Departments of Radiology (A.H., M.H., M.Y.T., C.A., K.K.K., M.N., N.T., H.K., S.S., N.H., S.A.).
authors: S
authors: 0000-0003-2821-0651
authors: S
authors: Aoki
mesh_terms: D000328:Adult; D004487:Edema / Q000000981:diagnostic imaging; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000000981:diagnostic imaging*; D009186:Myelin Sheath / Q000473:pathology*; D059906:Neuroimaging / Q000379:methods*; D066127:White Matter / Q000000981:diagnostic imaging*