title: Intramolecular Oxidative Arylations in 7-Azaindoles and Pyrroles: Revamping the Synthesis of Fused N-Heterocycle Tethered Fluorenes.
abstract: We revealed intramolecular oxidative arylations in 7-azaindoles and pyrroles that, for the first time, provided direct access to 7-azaindole- or pyrrole-fused isoindolines and tetrahydroisoquinolines. In addition, N-benzylation of 7-azaindoles or pyrroles with sterically hindered sec-benzyl alcohols by Mitsunobu reaction followed by intramolecular oxidative arylation allowed access to chiral congeners of fused isoindolines that have little precedence. A new opportunity in the design and synthesis of fluorene-based organic emitters is demonstrated in the preparation of novel fused N-heterocycle tethered fluorenes, including a chiral fluorene architecture.
authors: Department of Pharmaceutical Technology (Process Chemistry), National Institute of Pharmaceutical Educational and Research (NIPER), S.A. S. Nagar, Mohali-, 160062, India.
authors: Joydev K
authors: JK
authors: Laha
authors: Department of Pharmaceutical Technology (Process Chemistry), National Institute of Pharmaceutical Educational and Research (NIPER), S.A. S. Nagar, Mohali-, 160062, India.
authors: Rohan A
authors: RA
authors: Bhimpuria
authors: Department of Pharmaceutical Technology (Process Chemistry), National Institute of Pharmaceutical Educational and Research (NIPER), S.A. S. Nagar, Mohali-, 160062, India.
authors: Mandeep Kaur
authors: MK
authors: Hunjan
keywords: arylation; cross-coupling; fluorescence; fused-ring systems; nitrogen heterocycles