title: Gremlin-1 Concentrations Are Correlated with the Severity of Knee Osteoarthritis.
abstract: BACKGROUND Gremlin-1, a bone morphogenetic protein (BMP) antagonist, is up-regulated in osteoarthritis (OA). Therefore, we aim to evaluate the correlation between gremlin-1 concentrations and the onset and severity of OA. MATERIAL AND METHODS We performed this cross-sectional study in a population of 212 patients with knee OA and 125 healthy controls. RESULTS Patients with knee OA had higher serum gremlin-1 concentrations than healthy controls. Serum and synovial fluid (SF) gremlin-1 concentrations increased according to advanced Kellgren-Lawrence grading stages. CONCLUSIONS Serum and SF gremlin-1 concentrations are correlated with the onset and severity of knee OA.
authors: Department of Orthopaedics, Traditional Chinese Medicine Hospital, Shuyang, Jiangsu, China (mainland).
authors: Jun
authors: J
authors: Yi
authors: Department of Orthopaedics, General Hospital, Ningxia Medical University, Yinchuan, Ningxia, China (mainland).
authors: Qunhua
authors: Q
authors: Jin
authors: Department of Orthopaedics, Traditional Chinese Medicine Hospital, Shuyang, Jiangsu, China (mainland).
authors: Bin
authors: B
authors: Zhang
authors: Department of Orthopaedics, Traditional Chinese Medicine Hospital, Shuyang, Jiangsu, China (mainland).
authors: Xinqiu
authors: X
authors: Wu
authors: Department of Orthopaedics, Traditional Chinese Medicine Hospital, Shuyang, Jiangsu, China (mainland).
authors: Dawei
authors: D
authors: Ge
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D018450:Disease Progression; D005260:Female; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood / Q000235:genetics / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000097:blood / Q000235:genetics / Q000378:metabolism*; D012720:Severity of Illness Index; D013582:Synovial Fluid / Q000378:metabolism; D015854:Up-Regulation
chemical_list: D015415:Biomarkers; C486399:GREM1 protein, human; D036341:Intercellular Signaling Peptides and Proteins