title: Near-Infrared Photoacoustic Imaging Probe Responsive to Calcium.
abstract: Photoacoustic imaging (PAI) is an attractive imaging modality that can volumetrically map the distribution of photoabsorbing molecules with deeper tissue penetration than multiphoton microscopy. To enable dynamic sensing of divalent cations via PAI, we have engineered a new reversible near-infrared probe that is more sensitive to calcium as compared to other biologically relevant cations. The metallochromic compound showed a strong reduction of its peak absorbance at 765 nm upon addition of calcium ions that was translated into robust signal changes in photoacoustic images. Therefore, the heptamethine cyanine dye will be an attractive scaffold to create a series of metallochromic sensors for molecular PAI.
authors: Institute for Biological and Medical Imaging, Helmholtz Zentrum München , 85764 Neuherberg, Germany.|Institute of Developmental Genetics, Helmholtz Zentrum München , 85764 Neuherberg, Germany.
authors: Anurag
authors: A
authors: Mishra
authors: Institute for Biological and Medical Imaging, Helmholtz Zentrum München , 85764 Neuherberg, Germany.|Institute of Developmental Genetics, Helmholtz Zentrum München , 85764 Neuherberg, Germany.
authors: Yuanyuan
authors: Y
authors: Jiang
authors: Institute for Biological and Medical Imaging, Helmholtz Zentrum München , 85764 Neuherberg, Germany.|Institute of Developmental Genetics, Helmholtz Zentrum München , 85764 Neuherberg, Germany.|Department of Nuclear Medicine, Technical University of Munich , 81675 Munich, Germany.
authors: Sheryl
authors: S
authors: Roberts
authors: Institute for Biological and Medical Imaging, Helmholtz Zentrum München , 85764 Neuherberg, Germany.|Chair for Biological Imaging, Technical University of Munich , 80333 Munich, Germany.
authors: Vasilis
authors: V
authors: Ntziachristos
authors: Institute for Biological and Medical Imaging, Helmholtz Zentrum München , 85764 Neuherberg, Germany.|Institute of Developmental Genetics, Helmholtz Zentrum München , 85764 Neuherberg, Germany.|Department of Nuclear Medicine, Technical University of Munich , 81675 Munich, Germany.
authors: Gil G
authors: GG
authors: Westmeyer