title: Recent Developments of Hydrazide/Hydrazone Derivatives and Their Analogs as Anticonvulsant Agents in Animal Models.
abstract: Preclinical Research Epilepsy is a chronic devastating neurological disorder characterized by synchronous interictal discharges. Treatment with antiepileptic drugs (AEDs) can alleviate spontaneous seizure activity without preventing the progression and development of epileptogenesis. Current design and development of new AEDs and strategies for the prevention of epilepsy is focused mainly on attenuating uncontrolled seizures, severe side effects and toxicity in chronic drug therapy. It has thus become necessary to discover new chemical pharmacophores with a broad spectrum of activity and less neurotoxicity. Hydrazide/hydrazone derivatives that possess a -CO-NHN=CH- group constitute an important class of compounds for drug development. This review highlights the specific characteristics of various hydrazide/hydrazone derivatives and structurally related semicarbazones, semicarbazides and Schiff base compounds and their anticonvulsant activities. It is focused on the influence of differently substituted pharmacophores developed through SAR studies and testing their activity against different pharmcological targets. Drug Dev Res 77 : 379-392, 2016. © 2016 Wiley Periodicals, Inc.
authors: Department of Chemistry Faculty of Pharmacy, MU-Sofia, Sofia, Bulgaria.
authors: Violina
authors: V
authors: Angelova
authors: Department of Chemistry Faculty of Pharmacy, MU-Sofia, Sofia, Bulgaria.
authors: Valentin
authors: V
authors: Karabeliov
authors: Department of Pharmacology Medical Faculty, MU-Sofia, Bulgaria.
authors: Pavlina A
authors: PA
authors: Andreeva-Gateva
authors: Institute of Neurobiology, Bulgarian Academy of Sciences, Sofia, Bulgaria.
authors: Jana
authors: J
authors: Tchekalarova
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000009:adverse effects / Q000737:chemistry / Q000627:therapeutic use*; D004195:Disease Models, Animal; D015195:Drug Design; D004827:Epilepsy / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D006835:Hydrazones / Q000009:adverse effects / Q000737:chemistry / Q000627:therapeutic use*; D012545:Schiff Bases / Q000009:adverse effects / Q000737:chemistry / Q000627:therapeutic use; D012663:Semicarbazides / Q000009:adverse effects / Q000737:chemistry / Q000627:therapeutic use; D012664:Semicarbazones / Q000009:adverse effects / Q000737:chemistry / Q000627:therapeutic use; D013329:Structure-Activity Relationship
chemical_list: D000927:Anticonvulsants; D006835:Hydrazones; D012545:Schiff Bases; D012663:Semicarbazides; D012664:Semicarbazones
keywords: MES; PTZ; SAR; anticonvulsant activity; hydrazide/hydrazones