title: Kinetic changes of intestinal microbiota in the course of intestinal sensitization.
abstract: Food allergy (FA) is an adverse immune response to certain innocent food. It is estimated about 2% to 6% of the general population suffer from FA. Symptoms of a food allergic reaction may involve the gastrointestinal tract or/and other organs. The gut microbiota plays a critical role in diet-induced health problems. Whether the changes in the composition of the intestinal microbiota regulate allergic responses to food remains poorly understood. Thus, we created an FA animal model, sequenced the V4-V5 regions of 16S rRNA genes to characterize the genera abundance of gut microbiota. The results showed that mice under FA condition showed different gut bacterial structures. Diverse distribution of the bacterial species was identified between FA and control groups. FA altered the components of intestinal Microbiota in mice. The dysbiosis of the gut metagenome correlated with the development of the FA.
authors: The Research Center of Allergy and Immunology, Shenzhen University School of Medicine, Shenzhen 518060, China.|BGI Shenzhen, Shenzhen 518000, China.
authors: Liang
authors: L
authors: Xiao
authors: The Research Center of Allergy and Immunology, Shenzhen University School of Medicine, Shenzhen 518060, China.|Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China.
authors: Bo
authors: B
authors: Yang
authors: The Research Center of Allergy and Immunology, Shenzhen University School of Medicine, Shenzhen 518060, China.
authors: Xiaoyu
authors: X
authors: Liu
authors: The Research Center of Allergy and Immunology, Shenzhen University School of Medicine, Shenzhen 518060, China.
authors: Yan
authors: Y
authors: Luo
authors: The Research Center of Allergy and Immunology, Shenzhen University School of Medicine, Shenzhen 518060, China.
authors: Qiongmei
authors: Q
authors: Ji
authors: Department of Otolaryngology, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, China.
authors: Zhong
authors: Z
authors: Wen
authors: The Research Center of Allergy and Immunology, Shenzhen University School of Medicine, Shenzhen 518060, China.
authors: Zhigang
authors: Z
authors: Liu
authors: The Research Center of Allergy and Immunology, Shenzhen University School of Medicine, Shenzhen 518060, China.
authors: Ping-Chang
authors: PC
authors: Yang
mesh_terms: D000818:Animals; D001419:Bacteria / Q000145:classification / Q000235:genetics / Q000254:growth & development* / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000382:microbiology; D002478:Cells, Cultured; D004269:DNA, Bacterial / Q000235:genetics; D003713:Dendritic Cells / Q000276:immunology / Q000382:microbiology; D004195:Disease Models, Animal; D064806:Dysbiosis; D005512:Food Hypersensitivity / Q000276:immunology / Q000382:microbiology*; D000069196:Gastrointestinal Microbiome / Q000276:immunology; D007413:Intestinal Mucosa / Q000276:immunology / Q000382:microbiology*; D007583:Jejunum / Q000276:immunology / Q000382:microbiology*; D007700:Kinetics; D054892:Metagenome; D008807:Mice, Inbred BALB C; D010641:Phenotype; D021521:Ribotyping
chemical_list: D004269:DNA, Bacterial
keywords: 16S rRNA; animal model; food allergy; intestine; microbiota