title: Phenolic Melatonin-Related Compounds: Their Role as Chemical Protectors against Oxidative Stress.
abstract: There is currently no doubt about the serious threat that oxidative stress (OS) poses to human health. Therefore, a crucial strategy to maintain a good health status is to identify molecules capable of offering protection against OS through chemical routes. Based on the known efficiency of the phenolic and melatonin (MLT) families of compounds as antioxidants, it is logical to assume that phenolic MLT-related compounds should be (at least) equally efficient. Unfortunately, they have been less investigated than phenols, MLT and its non-phenolic metabolites in this context. The evidence reviewed here strongly suggests that MLT phenolic derivatives can act as both primary and secondary antioxidants, exerting their protection through diverse chemical routes. They all seem to be better free radical scavengers than MLT and Trolox, while some of them also surpass ascorbic acid and resveratrol. However, there are still many aspects that deserve further investigations for this kind of compounds.
authors: Departamento de Química, Universidad Autónoma Metropolitana-Iztapalapa, San Rafael Atlixco 186, Col. Vicentina, Iztapalapa, 09340 Mexico City, Mexico. agal@xanum.uam.mx.
authors: Annia
authors: A
authors: Galano
authors: Departamento de Química, Universidad Autónoma Metropolitana-Iztapalapa, San Rafael Atlixco 186, Col. Vicentina, Iztapalapa, 09340 Mexico City, Mexico. animor_ca@hotmail.com.
authors: Romina
authors: R
authors: Castañeda-Arriaga
authors: Consejo Nacional de Ciencia y Tecnología (CONACYT)-Departamento de Química, División de Ciencias Básicas e Ingeniería, Universidad Autónoma Metropolitana-Iztapalapa, Av. San Rafael Atlixco No. 186, Col. Vicentina, Iztapalapa, 09340 Mexico City, Mexico. adriana_perez_3@hotmail.com.
authors: Adriana
authors: A
authors: Pérez-González
authors: Department of Cellular and Structural Biology, UT Health Science Center, San Antonio, TX 78229, USA. Tan@uthscsa.edu.
authors: Dun-Xian
authors: DX
authors: Tan
authors: Department of Cellular and Structural Biology, UT Health Science Center, San Antonio, TX 78229, USA. REITER@uthscsa.edu.
authors: Russel J
authors: RJ
authors: Reiter
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology; D002839:Chromans / Q000494:pharmacology; D016166:Free Radical Scavengers / Q000737:chemistry; D006801:Humans; D008550:Melatonin / Q000031:analogs & derivatives* / Q000737:chemistry; D018384:Oxidative Stress / Q000187:drug effects*; D010636:Phenols / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D002839:Chromans; D016166:Free Radical Scavengers; D010636:Phenols; D008550:Melatonin; C010643:6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid
keywords: free radicals; kinetics; metal chelation; reaction mechanisms; scavenging activity; trends in activity