title: Nanomaterials for delivery of nucleic acid to the central nervous system (CNS).
abstract: Billions of dollars have been invested in the therapeutic application of nucleic acid-based agents in humans in recent years. There are inspirable data from ongoing clinical trial for different diseases. However, in order to widely apply nucleic acid in prevention, diagnosis and treatment of age-related disease, such as neurodegeneration and disorders, suitable, safe and effective drug delivery nanocarriers have to been developed to overcome the blood brain barrier (BBB), which is the most inflexible barrier in human body. Here, we highlight the structure and function of barriers in the central nervous system (CNS) and summary several types of nanomaterials which can be potentially used in the brain delivery nucleic acid.
authors: Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.
authors: Danyang
authors: D
authors: Wang
authors: Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark; Guangzhou RiboBio Co., Ltd., Guangzhou 510663, China. Electronic address: linping.wu@hotmail.com.
authors: Lin-Ping
authors: LP
authors: Wu
mesh_terms: D000818:Animals; D002490:Central Nervous System / Q000378:metabolism*; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry; D049329:Nanostructures / Q000737:chemistry*; D009696:Nucleic Acids / Q000008:administration & dosage*
chemical_list: D004337:Drug Carriers; D009696:Nucleic Acids
keywords: Blood brain barriers; Central nervous system; Drug delivery; Gene therapy; Nanomaterials; Nucleic acid; RNA interference