title: Changes in platelet parameters in leukocytosis.
abstract: BACKGROUND
  In recent years, platelets are known to have a large variety of functions in many pathophysiological processes and their interaction with endothelial cells and leukocytes is known to play an important role in the pathophysiology of vascular inflammation. The aim of this study was to investigate the relationship between white blood cell count in conditions resulting in leukocytosis and platelet count and platelet parameters including mean platelet volume, platelet distribution width, and plateletcrit.
  
  
  METHODS
  White blood cell counts count and all platelet parameters were evaluated in 341 results of normal complete blood count (of which the white blood cell counts were within reference range, group 1) and 327 results of elevated white blood cell counts count (group 2).
  
  
  RESULTS
  There was a significant difference between these two groups in PLT counts and PCT values, being higher in Group 2. However, there was no statistically significant difference between two groups in MPV and PDW values. On the other hand, there were statistically significant, but weak, correlations between the WBC and platelet counts in both groups (p<0.01, r=0.235 for group 1, p<0.05, r=0.116 for group 2).
  
  
  CONCLUSIONS
  As a conclusion PLT count and PCT values increase in infectious conditions. This study and previous studies show that PLTs are employed in infectious conditions but the exact mechanism and the exact clinical importance of this response remains to be cleared by further studies.
authors: Ataturk University Faculty of Medicine, Department of Medical Biochemistry, Erzurum, Turkey.
authors: Nurinnisa
authors: N
authors: Ozturk
authors: Ataturk University Faculty of Medicine, Department of Medical Biochemistry, Erzurum, Turkey.
authors: Nurcan Kilic
authors: NK
authors: Baygutalp
authors: Ataturk University Faculty of Medicine, Department of Medical Biochemistry, Erzurum, Turkey.
authors: Ebubekir
authors: E
authors: Bakan
authors: Dokuz Eylul University Faculty of Medicine, Department of Medical Biochemistry, Erzurum, Turkey.
authors: Gulsum Feyza
authors: GF
authors: Altas
authors: Ataturk University Faculty of Medicine, Department of Medical Biochemistry, Erzurum, Turkey.
authors: Harun
authors: H
authors: Polat
authors: Ataturk University Faculty of Medicine, Department of Medical Biochemistry, Erzurum, Turkey.
authors: Emrullah
authors: E
authors: Dorman
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001792:Blood Platelets / Q000378:metabolism*; D006801:Humans; D007958:Leukocyte Count; D007964:Leukocytosis / Q000378:metabolism*; D063847:Mean Platelet Volume; D008875:Middle Aged; D010976:Platelet Count; D012189:Retrospective Studies; D055815:Young Adult
keywords: Leukocytosis; platelet count; platelet parameters