title: Antiproliferative and anti-inflammatory furostanol saponins from the rhizomes of Tupistra chinensis.
abstract: Phytochemical investigations of the rhizome of Tupistra chinensis led to the isolation of ten new furostanol saponins along with fourteen known spirostanols. Their chemical structures were elucidated on the basis of spectroscopic and chemical methods, including IR, NMR, MS, and GC analyses. The antiproliferative effects against FaDu and Detroit 562 cell lines and inhibitory activities on nitric oxide (NO) production induced by lipopolysaccharide (LPS) in a macrophage cell line RAW 264.7 were assayed for all the isolated compounds. Compound 14 exhibited significant antiproliferative effects against FaDu and Detroit 562 cells with IC50values of 1.1±0.1 and 1.2±0.1μM, respectively. Compounds 1, 2, 6, 13, 16, 19 and 24 exhibited inhibitory effects on NO production with IC50values ranging from 15.7 to 46.2μM.
authors: School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China.
authors: Limin
authors: L
authors: Xiang
authors: School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China. Electronic address: wangyih88@163.com.
authors: Yihai
authors: Y
authors: Wang
authors: School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China.
authors: Xiaomin
authors: X
authors: Yi
authors: School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China. Electronic address: hexiangjiu@163.com.
authors: Xiangjiu
authors: X
authors: He
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents; D002460:Cell Line; D006801:Humans; D019668:Liliaceae / Q000737:chemistry*; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D009569:Nitric Oxide / Q000378:metabolism; D000067996:RAW 264.7 Cells; D027343:Rhizome / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000893:Anti-Inflammatory Agents; D008070:Lipopolysaccharides; D012503:Saponins; D009569:Nitric Oxide
keywords: Anti-inflammatory activity; Antiproliferative activity; Furostanol saponins; Tupistra chinensis