title: Hepatocellular adenoma among adult survivors of childhood and young adult cancer.
abstract: Hepatocellular adenoma (HCA) is a rare benign epithelial neoplasm with potential for hemorrhage, rupture, or malignant transformation. Reported annual incidence of HCA is approximately 1/1,000,000. We identified 12 cases of HCA among adults with a history of childhood or young adult cancer. The most common cancer diagnosis was leukemia (N = 4). Five had undergone allogeneic hematopoietic stem cell transplant with total body irradiation. All 11 females had prior estrogen therapy; the male case was hypogonadal. This report suggests childhood and young adult cancer survivors may be at increased risk for HCA, but further investigation is needed.
authors: Adult Long Term Follow-Up Program, Memorial Sloan Kettering, New York, New York.|Weill Cornell Medical College, New York, New York.
authors: Emily S
authors: ES
authors: Tonorezos
authors: Adult Long Term Follow-Up Program, Memorial Sloan Kettering, New York, New York.
authors: Dana
authors: D
authors: Barnea
authors: Adult Long Term Follow-Up Program, Memorial Sloan Kettering, New York, New York.|Weill Cornell Medical College, New York, New York.
authors: Ghassan K
authors: GK
authors: Abou-Alfa
authors: Adult Long Term Follow-Up Program, Memorial Sloan Kettering, New York, New York.
authors: Jacqueline
authors: J
authors: Bromberg
authors: Adult Long Term Follow-Up Program, Memorial Sloan Kettering, New York, New York.|Weill Cornell Medical College, New York, New York.
authors: Michael
authors: M
authors: D'Angelica
authors: Adult Long Term Follow-Up Program, Memorial Sloan Kettering, New York, New York.
authors: Charles A
authors: CA
authors: Sklar
authors: Adult Long Term Follow-Up Program, Memorial Sloan Kettering, New York, New York.|Weill Cornell Medical College, New York, New York.
authors: Jinru
authors: J
authors: Shia
authors: Adult Long Term Follow-Up Program, Memorial Sloan Kettering, New York, New York.
authors: Kevin C
authors: KC
authors: Oeffinger
mesh_terms: D018248:Adenoma, Liver Cell / Q000209:etiology* / Q000473:pathology; D000293:Adolescent; D000328:Adult; D006528:Carcinoma, Hepatocellular / Q000209:etiology* / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D007223:Infant; D008113:Liver Neoplasms / Q000209:etiology* / Q000473:pathology; D008297:Male; D009367:Neoplasm Staging; D009369:Neoplasms / Q000150:complications* / Q000473:pathology / Q000628:therapy; D011379:Prognosis; D015996:Survival Rate; D017741:Survivors; D014916:Whole-Body Irradiation / Q000009:adverse effects*; D055815:Young Adult
keywords: childhood cancer; hepatocellular adenoma; hepatoma; survivor