title: Microstructure, mechanical properties, bio-corrosion properties and cytotoxicity of as-extruded Mg-Sr alloys.
abstract: In this study, as-extruded Mg-Sr alloys were studied for orthopedic application, and the microstructure, mechanical properties, bio-corrosion properties and cytotoxicity of as-extruded Mg-Sr alloys were investigated by optical microscopy, scanning electron microscopy with an energy dispersive X-ray spectroscopy, X-ray diffraction, tensile and compressive tests, immersion test, electrochemical test and cytotoxicity test. The results showed that as-extruded Mg-Sr alloys were composed of α-Mg and Mg17Sr2phases, and the content of Mg17Sr2phases increased with increasing Sr content. As-extruded Mg-Sr alloy with 0.5wt.% Sr was equiaxed grains, while the one with a higher Sr content was long elongated grains and the grain size of the long elongated grains decreased with increasing Sr content. Tensile and compressive tests showed an increase of both tensile and compressive strength and a decrease of elongation with increasing Sr content. Immersion and electrochemical tests showed that as-extruded Mg-0.5Sr alloy exhibited the best anti-corrosion property, and the anti-corrosion property of as-extruded Mg-Sr alloys deteriorated with increasing Sr content, which was greatly associated with galvanic couple effect. The cytotoxicity test revealed that as-extruded Mg-0.5Sr alloy did not induce toxicity to cells. These results indicated that as-extruded Mg-0.5Sr alloy with suitable mechanical properties, corrosion resistance and good cytocompatibility was potential as a biodegradable implant for orthopedic application.
authors: College of Materials Science and Engineering, Chongqing University, Chongqing 400044, China.
authors: Chaoyong
authors: C
authors: Zhao
authors: College of Materials Science and Engineering, Chongqing University, Chongqing 400044, China; National Engineering Research Center for Magnesium Alloys, Chongqing University, Chongqing 400044, China; Chongqing Academy of Science and Technology, Chongqing 401123, China. Electronic address: fspan@cqu.edu.cn.
authors: Fusheng
authors: F
authors: Pan
authors: College of Materials Science and Engineering, Chongqing University, Chongqing 400044, China.
authors: Lei
authors: L
authors: Zhang
authors: College of Materials Science and Engineering, Chongqing University, Chongqing 400044, China.
authors: Hucheng
authors: H
authors: Pan
authors: College of Materials Science and Engineering, Chongqing University, Chongqing 400044, China.
authors: Kai
authors: K
authors: Song
authors: College of Materials Science and Engineering, Chongqing University, Chongqing 400044, China.
authors: Aitao
authors: A
authors: Tang
mesh_terms: D000497:Alloys / Q000494:pharmacology*; D016923:Cell Death / Q000187:drug effects; D045744:Cell Line, Tumor; D048430:Cell Shape / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D019245:Compressive Strength / Q000187:drug effects; D003343:Corrosion; D004563:Electrochemistry; D006801:Humans; D006863:Hydrogen-Ion Concentration; D055595:Mechanical Phenomena; D008970:Molecular Weight; D012996:Solutions; D013718:Tensile Strength / Q000187:drug effects; D014961:X-Ray Diffraction
chemical_list: D000497:Alloys; C573915:Mg-Sr alloy; D012996:Solutions
keywords: Biodegradation; Corrosion; Magnesium alloy; Mg-Sr; Orthopedic implant