title: Thrombotic issues in transgender medicine: A review.
abstract: Clinicians, including hematologists, are more frequently encountering transgender individuals in practice; however, most lack training on the management and complications of transgender medicine. Hormonal therapy forms the backbone of medical interventions for patients undergoing gender transition. While supplementing an individual's intrinsic sex hormone is associated with a variety of hematologic complications including increased rates of venous thrombosis, cardiovascular events, erthyrocytosis, and malignancy, the risks of supplementing with opposing sex hormones are not well understood. Data on the hematologic complications of these therapies are accumulating but remain limited, and clinicians have little experience with their management. This review highlights the current interventions available in transgender medicine and related potential hematologic complications, and it suggests simple, evidence-based management going forward. Am. J. Hematol. 92:204-208, 2017. © 2016 Wiley Periodicals, Inc.
authors: Division of Hematology/Medical Oncology, Knight Cancer Institute, Portland, Oregon.
authors: Joseph J
authors: JJ
authors: Shatzel
authors: Department of Pediatrics, Oregon Health & Science University, Portland, Oregon.
authors: Kara J
authors: KJ
authors: Connelly
authors: Division of Hematology/Medical Oncology, Knight Cancer Institute, Portland, Oregon.|Department of Pediatrics, Oregon Health & Science University, Portland, Oregon.|Department of Pathology, Oregon Health & Science University, Portland, Oregon.
authors: Thomas G
authors: TG
authors: DeLoughery
mesh_terms: D005260:Female; D062985:Health Services for Transgender Persons; D020249:Hormone Replacement Therapy / Q000009:adverse effects* / Q000379:methods; D006801:Humans; D015994:Incidence; D008297:Male; D063106:Transgender Persons; D020246:Venous Thrombosis / Q000453:epidemiology / Q000209:etiology / Q000628:therapy