title: Preparation and in vitro study of hydrochloric norvancomycin encapsulated poly (d,l-lactide-co-glycolide, PLGA) microspheres for potential use in osteomyelitis.
abstract: HNV-loaded PLGA microspheres (HNV-PLGA MSs) were prepared by water-in-oil-in-water (w/o/w) double emulsion solvent evaporation technique. The surface of prepared HNV-PLGA MSs is smooth and nonporous with an average diameter of 69.9 μm. The drug-loading rate and encapsulation rate of HNV-PLGA MSs are 4.40 ± 0.26% and 48.51 ± 14.83%, respectively. Additionally, 43.36% of HNV was released from PLGA MSs after seven days of incubation. The antibacterial effects of HNV released from PLGA were as good as the pure HNV. HNV-loaded PLGA microspheres were successfully prepared using double emulsion solvent evaporation technique and their properties met the requirements for local anti-infection.
authors: a Department of Orthopedic Trauma , Affiliated General Hospital, Ning Xia Medical University , Yinchuan , China.
authors: Haibo
authors: H
authors: Yang
authors: b Hebei Province People's Hospital , Qian'an , China.
authors: Yujie
authors: Y
authors: Hao
authors: a Department of Orthopedic Trauma , Affiliated General Hospital, Ning Xia Medical University , Yinchuan , China.
authors: Qiming
authors: Q
authors: Liu
authors: a Department of Orthopedic Trauma , Affiliated General Hospital, Ning Xia Medical University , Yinchuan , China.
authors: Zhanhu
authors: Z
authors: Mi
authors: c Ning Xia Medical University , Yinchuan , China.
authors: Zhibin
authors: Z
authors: Wang
authors: c Ning Xia Medical University , Yinchuan , China.
authors: Lei
authors: L
authors: Zhu
authors: d State Key Laboratory of New Ceramics and Fine Processing, Department of Materials Science and Engineering , Tsinghua University , Beijing , China.
authors: Qingling
authors: Q
authors: Feng
authors: a Department of Orthopedic Trauma , Affiliated General Hospital, Ning Xia Medical University , Yinchuan , China.
authors: Ningmin
authors: N
authors: Hu
mesh_terms: D002214:Capsules; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D019344:Lactic Acid / Q000737:chemistry*; D008863:Microspheres; D009821:Oils / Q000737:chemistry; D010019:Osteomyelitis / Q000188:drug therapy*; D010316:Particle Size; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D014640:Vancomycin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000627:therapeutic use; D014867:Water / Q000737:chemistry
chemical_list: D002214:Capsules; D004337:Drug Carriers; D009821:Oils; D014867:Water; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D014640:Vancomycin; C511195:norvancomycin
keywords: Antibacterial effects; L-lactide-co-glycolide; PLGA); hydrochloric norvancomycin; poly (D; solvent evaporation technique