title: Determination of carboxylic acids in non-alcoholic beer samples by an ultrasonic-assisted dispersive micro-solid phase extraction based on Ni/Cu-Al layered double hydroxide nanocomposites followed by gas chromatography.
abstract: Magnetically separable layered double hydroxide Ni/CuAl-LDH nanocomposites were synthesized and employed as ultrasonic-assisted dispersive micro-solid phase extraction (UA-D-μSPE) sorbent to extract several carboxylic acids (namely propionic, butyric, pentanoic, hexanoic, heptanoic, octanoic, and decanoic) from non-alcoholic beer samples. Ni/CuAl-LDH sorbent was characterized by Fourier transform-infrared (FTIR) spectroscopy, transmission electron microscopy (TEM), and vibrating sample magnetometry (VSM). Effective variables such as amount of sorbent (mg), pH and ionic strength of sample solution, volume of eluent solvent (μL), vortex, and ultrasonic times (min) were investigated via fractional factorial design (FFD). The significant variables were optimized by a Box-Behnken design and combined by a desirability function (DF). Under optimized conditions, the calibration graphs of analytes were linear in a concentration range of 0.05-100μg/mL and had correlation coefficients more than 0.997. The limits of detection and quantification were in the ranges of 16-40μg/L and 53-133μg/L, respectively. This procedure was successfully employed in the determination of target analytes in spiked beer samples, and the relative mean recoveries ranged from 87 to 110%.
authors: Department of Chemistry, Faculty of Science, Ilam University, Ilam 69315-516, Iran.
authors: Shirin
authors: S
authors: Babaee
authors: Department of Chemistry, Faculty of Science, Ilam University, Ilam 69315-516, Iran. Electronic address: daneshfara@yahoo.com.
authors: Ali
authors: A
authors: Daneshfar
authors: Department of Chemistry, Faculty of Science, Ilam University, Ilam 69315-516, Iran.
authors: Tahere
authors: T
authors: Khezeli
mesh_terms: D000535:Aluminum / Q000737:chemistry; D001515:Beer / Q000032:analysis*; D002264:Carboxylic Acids / Q000032:analysis* / Q000302:isolation & purification; D002849:Chromatography, Gas; D003300:Copper / Q000737:chemistry; D006878:Hydroxides / Q000737:chemistry*; D008670:Metals / Q000737:chemistry*; D053761:Nanocomposites / Q000737:chemistry*; D009532:Nickel / Q000737:chemistry; D052617:Solid Phase Microextraction / Q000379:methods*; D012997:Solvents / Q000737:chemistry; D000069453:Ultrasonic Waves
chemical_list: D002264:Carboxylic Acids; D006878:Hydroxides; D008670:Metals; D012997:Solvents; D003300:Copper; D009532:Nickel; D000535:Aluminum
keywords: Box–Behnken design; Carboxylic acids; Fractional factorial design; Nanocomposites; Ni/CuAl-LDH; Ultrasonic-assisted dispersive micro-solid-phase extraction