title: Clinical manifestations and pathogenesis of cutaneous lymphomas: current status and future directions.
abstract: The primary cutaneous lymphomas are a heterogeneous group of T-, Natural Killer- and B- cell neoplasms with a wide range of clinical and pathological presentations, and with very different prognoses compared to systemic lymphomas. Recent studies have shown that the skin microenvironment, which is composed of various immune cell subsets as well as their spatial distribution and T-cell interactions through different chemokines and cytokines, has an important role in the development and pathogenesis of cutaneous lymphomas and has assisted in the development of novel and more effective immunotherapies. The following review will focus on the major subtypes of primary cutaneous lymphomas, including the clinical and histological patterns, molecular hallmarks, and current and future treatment strategies.
authors: Department of Pathology, City of Hope, Duarte, CA, USA.
authors: Belen
authors: B
authors: Rubio-Gonzalez
authors: Department of Hematology/Hematopoietic Cell Transplantation, City of Hope, Duarte, CA, USA.
authors: Jasmine
authors: J
authors: Zain
authors: Department of Hematology/Hematopoietic Cell Transplantation, City of Hope, Duarte, CA, USA.
authors: Steven T
authors: ST
authors: Rosen
authors: Department of Pathology, City of Hope, Duarte, CA, USA.|Department of Hematology/Hematopoietic Cell Transplantation, City of Hope, Duarte, CA, USA.|Division of Dermatology, City of Hope, Duarte, CA, USA.
authors: Christiane
authors: C
authors: Querfeld
mesh_terms: D016207:Cytokines / Q000276:immunology; D006801:Humans; D007167:Immunotherapy / Q000639:trends; D008214:Lymphocytes / Q000473:pathology; D016410:Lymphoma, T-Cell, Cutaneous / Q000145:classification / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy*; D012867:Skin / Q000276:immunology; D012878:Skin Neoplasms / Q000276:immunology / Q000473:pathology
chemical_list: D016207:Cytokines
keywords: immune checkpoints; primary cutaneous lymphomas; treatment strategies; tumour microenvironment