title: Stereotactic ablative radiotherapy for early stage non-small cell lung cancer: A critical literature review of predictive factors of relapse.
abstract: Stereotactic ablative radiation therapy (SABR) has become the standard treatment for peripheral medically non-operable patients with early stage non-small cell lung cancer (NSCLC). Previous attempts of trials to compare SABR and surgery have failed and new randomized studies (SABRtooth, STABLEMATES, and VALOR) are ongoing. While predictive factors of relapse have been extensively studied in patients receiving surgery, there is scarce data on such putative factors in SABR patients. The purpose of this review is to analyze such predictive factors through a critical review of the literature.
authors: Department of Radiation Oncology, Institut d'Oncologie Thoracique (IOT), Gustave Roussy, Université Paris-Saclay, F-94805 Villejuif, France.
authors: Gokoulakrichenane
authors: G
authors: Loganadane
authors: Department of Radiation Oncology, Institut d'Oncologie Thoracique (IOT), Gustave Roussy, Université Paris-Saclay, F-94805 Villejuif, France; Department of Medical Physics, Gustave Roussy Cancer Campus, Villejuif, France.
authors: Florent
authors: F
authors: Martinetti
authors: Department of Thoracic and Vascular Surgery and Heart-Lung Transplantation, Institut d'Oncologie Thoracique (IOT), Marie-Lannelongue Hospital, Paris Sud University, 133 Avenue de la Résistance, 92350 Le Plessis Robinson, France.
authors: Olaf
authors: O
authors: Mercier
authors: Department of Radiation Oncology, Institut d'Oncologie Thoracique (IOT), Gustave Roussy, Université Paris-Saclay, F-94805 Villejuif, France.
authors: Samar
authors: S
authors: Krhili
authors: Department of Radiation Oncology, Institut d'Oncologie Thoracique (IOT), Gustave Roussy, Université Paris-Saclay, F-94805 Villejuif, France.
authors: François-Georges
authors: FG
authors: Riet
authors: Department of Radiation Oncology, Institut d'Oncologie Thoracique (IOT), Gustave Roussy, Université Paris-Saclay, F-94805 Villejuif, France.
authors: Rodrigue
authors: R
authors: Mbagui
authors: Department of Radiation Oncology, Institut d'Oncologie Thoracique (IOT), Gustave Roussy, Université Paris-Saclay, F-94805 Villejuif, France.
authors: Hanh
authors: H
authors: To
authors: Department of Radiation Oncology, Institut d'Oncologie Thoracique (IOT), Gustave Roussy, Université Paris-Saclay, F-94805 Villejuif, France.
authors: Cécile
authors: C
authors: Le Péchoux
authors: Department of Radiation Oncology, Institut d'Oncologie Thoracique (IOT), Gustave Roussy, Université Paris-Saclay, F-94805 Villejuif, France; INSERM U1030, Molecular Radiotherapy, Gustave Roussy, Université Paris-Saclay, F-94805 Villejuif, France; Univ Paris Sud, Université Paris-Saclay, F-94270 Le Kremlin-Bicêtre, France. Electronic address: Antonin.LEVY@gustaveroussy.fr.
authors: Antonin
authors: A
authors: Levy
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging / Q000473:pathology / Q000532:radiotherapy*; D002289:Carcinoma, Non-Small-Cell Lung / Q000000981:diagnostic imaging / Q000473:pathology / Q000532:radiotherapy*; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging / Q000473:pathology / Q000532:radiotherapy*; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000532:radiotherapy*; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology*; D009367:Neoplasm Staging; D000072078:Positron Emission Tomography Computed Tomography; D016634:Radiosurgery / Q000379:methods*; D061089:Radiotherapy, Image-Guided; D012307:Risk Factors; D016896:Treatment Outcome; D047368:Tumor Burden
keywords: Local relapse; Lung cancer; Stereotactic ablative radiation therapy (SABR); Stereotactic body radiotherapy (SBRT); Surgery