title: Can the composition of the intestinal microbiota predict the development of urinary tract infections?
abstract: To evaluate whether intestinal microbiota predicts the development of new-onset urinary tract infections (UTIs) in postmenopausal women with prior recurrent UTIs (rUTIs).
  
  
  
  Fecal samples (n = 40) originated from women with rUTI who received 12 months' prophylaxis of either trimethoprim-sulfamethoxazole (TMP-SMX) or lactobacilli. Microbial composition was assessed by 16S rRNA pyrosequencing.
  
  
  
  At baseline, fecal microbiota of women with zero and more than or equal to four UTIs during follow-up showed no significant differences. Only TMP-SMX prophylaxis resulted in reduced microbial diversity. Microbial structure of two samples from the same woman showed limited relatedness.
  
  
  
  In postmenopausal women with rUTI, the intestinal microbiota was not predictive for new-onset UTIs. Only TMP-SMX, and not lactobacilli, prophylaxis had effects on the microbial composition. Data in ENA:PRJEB13868.
authors: Department of Medical Microbiology, Maastricht University Medical Centre/Care & Public Health Research Institute (CAPHRI), Maastricht, The Netherlands.
authors: Casper Dj
authors: CD
authors: den Heijer
authors: Department of Internal Medicine, Division of Infectious Diseases & Centre for Infection & Immunity Amsterdam (CINIMA), Academic Medical Centre, Amsterdam, The Netherlands.
authors: Suzanne E
authors: SE
authors: Geerlings
authors: Department of Internal Medicine, Division of Infectious Diseases & Centre for Infection & Immunity Amsterdam (CINIMA), Academic Medical Centre, Amsterdam, The Netherlands.
authors: Jan M
authors: JM
authors: Prins
authors: Department of Internal Medicine, Division of Infectious Diseases & Centre for Infection & Immunity Amsterdam (CINIMA), Academic Medical Centre, Amsterdam, The Netherlands.
authors: Mariëlle Aj
authors: MA
authors: Beerepoot
authors: National Institute for Public Health & the Environment, Centre for Infectious Disease Control Netherlands (CIb), Bilthoven, The Netherlands.
authors: Ellen E
authors: EE
authors: Stobberingh
authors: Department of Medical Microbiology, Maastricht University Medical Centre/Care & Public Health Research Institute (CAPHRI), Maastricht, The Netherlands.
authors: John
authors: J
authors: Penders
mesh_terms: D019072:Antibiotic Prophylaxis; D044822:Biodiversity; D004269:DNA, Bacterial; D005243:Feces / Q000382:microbiology; D005260:Female; D000069196:Gastrointestinal Microbiome / Q000187:drug effects* / Q000235:genetics; D006801:Humans; D007778:Lactobacillus; D008827:Microbiological Phenomena / Q000187:drug effects* / Q000235:genetics; D008875:Middle Aged; D010802:Phylogeny; D017698:Postmenopause; D019936:Probiotics / Q000627:therapeutic use; D012336:RNA, Ribosomal, 16S / Q000235:genetics; D013997:Time Factors; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use; D014552:Urinary Tract Infections / Q000188:drug therapy* / Q000382:microbiology* / Q000517:prevention & control
chemical_list: D004269:DNA, Bacterial; D012336:RNA, Ribosomal, 16S; D015662:Trimethoprim, Sulfamethoxazole Drug Combination
keywords: 16S rRNA pyrosequencing; intestinal microbiota; lactobacilli; postmenopausal women; prophylaxis; trimethoprim-sulfamethoxazole; urinary tract infection