title: RNAs as chaperones.
abstract: Recently, we found that RNA is a remarkably powerful chaperone that can bind to unfolded proteins and transfer them to Hsp70 for refolding. Combined with past studies on RNA-chaperone interactions, we propose a model for how chaperone RNA activity may contribute to the cellular response to stress.
authors: a University of Michigan, Department of Molecular, Cellular, and Developmental Biology , Ann Arbor , MI , USA.|b Howard Hughes Medical Institute , Chevy Chase , MD , USA.
authors: Scott
authors: S
authors: Horowitz
authors: a University of Michigan, Department of Molecular, Cellular, and Developmental Biology , Ann Arbor , MI , USA.|b Howard Hughes Medical Institute , Chevy Chase , MD , USA.
authors: James C A
authors: JC
authors: Bardwell
mesh_terms: D018840:HSP70 Heat-Shock Proteins / Q000378:metabolism*; D008958:Models, Molecular; D018832:Molecular Chaperones / Q000378:metabolism; D017510:Protein Folding; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism; D012313:RNA / Q000378:metabolism*; D013312:Stress, Physiological
chemical_list: D018840:HSP70 Heat-Shock Proteins; D018832:Molecular Chaperones; D011506:Proteins; D012313:RNA
keywords: AU-rich elements; Hsp70; RNA; chaperone; stress granules