title: Nanoparticles for cancer gene therapy: Recent advances, challenges, and strategies.
abstract: Compared to conventional treatments, gene therapy offers a variety of advantages for cancer treatment including high potency and specificity, low off-target toxicity, and delivery of multiple genes that concurrently target cancer tumorigenesis, recurrence, and drug resistance. In the past decades, gene therapy has undergone remarkable progress, and is now poised to become a first line therapy for cancer. Among various gene delivery systems, nanoparticles have attracted much attention because of their desirable characteristics including low toxicity profiles, well-controlled and high gene delivery efficiency, and multi-functionalities. This review provides an overview on gene therapeutics and gene delivery technologies, and highlight recent advances, challenges and insights into the design and the utility of nanoparticles in gene therapy for cancer treatment.
authors: Department of Materials Science and Engineering, University of Washington, Seattle, WA 98195, USA.
authors: Kui
authors: K
authors: Wang
authors: Department of Neurological Surgery, University of Washington, Seattle, WA 98195, USA.
authors: Forrest M
authors: FM
authors: Kievit
authors: Department of Materials Science and Engineering, University of Washington, Seattle, WA 98195, USA; Department of Neurological Surgery, University of Washington, Seattle, WA 98195, USA. Electronic address: mzhang@u.washington.edu.
authors: Miqin
authors: M
authors: Zhang
mesh_terms: D000818:Animals; D015972:Gene Expression Regulation, Neoplastic; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D007167:Immunotherapy / Q000379:methods; D050997:Nanomedicine / Q000379:methods; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods; D009369:Neoplasms / Q000235:genetics* / Q000628:therapy*
keywords: Cancer gene therapy; Gene delivery; Nanoparticles