title: Toxicity of graphene-family nanoparticles: a general review of the origins and mechanisms.
abstract: Due to their unique physicochemical properties, graphene-family nanomaterials (GFNs) are widely used in many fields, especially in biomedical applications. Currently, many studies have investigated the biocompatibility and toxicity of GFNs in vivo and in intro. Generally, GFNs may exert different degrees of toxicity in animals or cell models by following with different administration routes and penetrating through physiological barriers, subsequently being distributed in tissues or located in cells, eventually being excreted out of the bodies. This review collects studies on the toxic effects of GFNs in several organs and cell models. We also point out that various factors determine the toxicity of GFNs including the lateral size, surface structure, functionalization, charge, impurities, aggregations, and corona effect ect. In addition, several typical mechanisms underlying GFN toxicity have been revealed, for instance, physical destruction, oxidative stress, DNA damage, inflammatory response, apoptosis, autophagy, and necrosis. In these mechanisms, (toll-like receptors-) TLR-, transforming growth factor β- (TGF-β-) and tumor necrosis factor-alpha (TNF-α) dependent-pathways are involved in the signalling pathway network, and oxidative stress plays a crucial role in these pathways. In this review, we summarize the available information on regulating factors and the mechanisms of GFNs toxicity, and propose some challenges and suggestions for further investigations of GFNs, with the aim of completing the toxicology mechanisms, and providing suggestions to improve the biological safety of GFNs and facilitate their wide application.
authors: The First Affiliated Hospital of Jinan University, Guangzhou, China.
authors: Lingling
authors: L
authors: Ou
authors: Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
authors: Bin
authors: B
authors: Song
authors: Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
authors: Huimin
authors: H
authors: Liang
authors: Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
authors: Jia
authors: J
authors: Liu
authors: Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
authors: Xiaoli
authors: X
authors: Feng
authors: The General Hospital of People's Liberation Army, Beijing, China.
authors: Bin
authors: B
authors: Deng
authors: The First Affiliated Hospital of Jinan University, Guangzhou, China.
authors: Ting
authors: T
authors: Sun
authors: Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. shaolongquan@smu.edu.cn.
authors: Longquan
authors: L
authors: Shao
mesh_terms: D000818:Animals; D004333:Drug Administration Routes; D006108:Graphite / Q000633:toxicity*; D053758:Nanoparticles / Q000633:toxicity*; D014018:Tissue Distribution
chemical_list: D006108:Graphite
keywords: Future prospects; Graphene-family nanomaterials; Mechanisms; Physicochemical properties; Toxicity; Toxicokinetics