title: A painful TR(i)P to lysosomes.
abstract: The ion channel TRPA1 detects noxious stimuli at the plasma membrane of neurons and elicits pain and inflammation. In this issue, Shang et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201603081) report that TRPA1 also localizes to lysosomal membranes of neurons, releasing intracellular Ca2+to trigger vesicle exocytosis and neuropeptide release.
authors: The Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109.
authors: Mingxue
authors: M
authors: Gu
authors: The Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109 haoxingx@umich.edu.
authors: Haoxing
authors: H
authors: Xu
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D057809:HEK293 Cells; D006801:Humans; D007425:Intracellular Membranes / Q000378:metabolism; D008247:Lysosomes / Q000378:metabolism*; D051379:Mice; D050051:Transient Receptor Potential Channels / Q000378:metabolism*
chemical_list: D050051:Transient Receptor Potential Channels; D002118:Calcium