title: One-pot synthesis of folic acid encapsulated upconversion nanoscale metal organic frameworks for targeting, imaging and pH responsive drug release.
abstract: In this work, a new theranostic nanoplatform is developed to construct an anticancer drug carrier by integrating the distinct advantages of upconversion nanoparticles (UCNPs) and metal organic frameworks (MOFs) encapsulated with a targeting ligand. Here NaYF4:Yb3+,Er3+is chosen as an upconversion nanoparticle for its high luminescence properties. Then, folic acid encapsulated Zeolitic Imidazolate Framework-8 (ZIF-8) is directly coated on UCNPs in one step to form a monodispersed core-shell structured nanocomposite (labeled as UCNPs@ZIF-8/FA). The synthesized upconversion nanoscale MOFs (NMOFs) are simultaneously used as a targeted anticancer drug carrier and in cellular imaging. The UCNP@ZIF-8/FA nanocomposites are found to be nontoxic towards the human cervix adenocarcinoma (HeLa) and mouse fibroblast (L929) cell lines via a cell viability assay. It is worthwhile noting that, the anticancer drug 5-fluorouracil (5-FU) is absorbed into UCNP@ZIF-8/FA nanocomposites (loading amount 685 mg g-1) and also pH responsive drug release is observed. The as-prepared 5-FU loaded UCNP@ZIF-8/FA nanocomposites exhibited greater cytotoxicity towards HeLa cells due to the folate receptor-mediated endocytosis. Our study highlights the potential of developing multifunctional upconversion NMOFs for simultaneous targeted cellular imaging with delivery of anticancer drugs.
authors: Department of Applied Chemistry, Indian Institute of Technology (Indian School of Mines), Dhanbad 826004, Jharkhand, India. sahu.s.ac@ismdhanbad.ac.in sumantchem@gmail.com.
authors: Angshuman Ray
authors: AR
authors: Chowdhuri
authors: Department of Life Science and Biotechnology, Jadavpur University, 188, Raja S C Mallick Road, Kolkata 700032, India and Division of Molecular Medicine, Bose Institute, Kolkata, 700054, India.
authors: Dipranjan
authors: D
authors: Laha
authors: Department of Applied Chemistry, Indian Institute of Technology (Indian School of Mines), Dhanbad 826004, Jharkhand, India. sahu.s.ac@ismdhanbad.ac.in sumantchem@gmail.com.
authors: Srimanta
authors: S
authors: Pal
authors: Department of Life Science and Biotechnology, Jadavpur University, 188, Raja S C Mallick Road, Kolkata 700032, India.
authors: Parimal
authors: P
authors: Karmakar
authors: Department of Applied Chemistry, Indian Institute of Technology (Indian School of Mines), Dhanbad 826004, Jharkhand, India. sahu.s.ac@ismdhanbad.ac.in sumantchem@gmail.com.
authors: Sumanta Kumar
authors: SK
authors: Sahu