title: Dynamic contrast-enhanced magnetic resonance imaging for pretreatment prediction of early chemo-radiotherapy response in larynx and hypopharynx carcinoma.
abstract: OBJECTIVE
  This study is to investigate the use of dynamic contrast-enhanced magnetic resonance imaging in predicting early response to CRT (chemo-radiotherapy) in patients with larynx and hypopharynx carcinoma from primary tumors.
  
  
  METHODS
  Sixty-two patients with larynx and hypopharynx carcinoma underwent two DCE-MRI studies: a baseline exam before any treatmentanda post-treatment exam 3 weeks after CRT. At the end of treatment, patients were classified as responders, or non-responders according to the Response Evaluation Criteria in Solid Tumors criteria (RECIST). The time intensity curves (TIC) were extracted and processed to obtain time to peak (TTP), maximum slope of increase (MSI), maximum slope of decrease (MSD) and positive enhancement integral (PEI), and the semi-quantitative MRI parameters were compared and analyzed between the two groups.
  
  
  RESULTS
  Fifty-four and 8 patients were included the responder and non-responder groups. It was observed that the MSI, MSD, and PEI were significantly lower post-treatment than pre-treatment(P < 0.05). The pretreatment MSI, MSD, and PEI parameters of responders were significantly higher than those of non-responders (P< 0.05). The post-treatment MSI, MSD, and PEI parameters of responders were significantly lower than those of non-responders (P< 0.05). Based on ROC curve analysis, at a threshold of 154.81 for pretreatment MSI, the corresponding AUC, sensitivity, and specificity were 0.882, 89.3% and 73.5%, respectively.
  
  
  CONCLUSIONS
  The semi-quantitative DCE-MRI may aid in the prediction of early response to CRT in patients with larynx and hypopharynx carcinoma.
authors: Department of Diagnostic Radiology, Peking Union Medical College, Cancer Institute & Hospital, Chinese Academy of Medical Sciences, Beijing,China.
authors: Wei
authors: W
authors: Guo
authors: Department of Diagnostic Radiology, Peking Union Medical College, Cancer Institute & Hospital, Chinese Academy of Medical Sciences, Beijing,China.
authors: Dehong
authors: D
authors: Luo
authors: Department of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
authors: Xinyi
authors: X
authors: Chen
authors: Department of Diagnostic Radiology, Peking Union Medical College, Cancer Institute & Hospital, Chinese Academy of Medical Sciences, Beijing,China.
authors: Meng
authors: M
authors: Lin
authors: Department of Diagnostic Radiology, Peking Union Medical College, Cancer Institute & Hospital, Chinese Academy of Medical Sciences, Beijing,China.
authors: Lin
authors: L
authors: Li
authors: Department of Diagnostic Radiology, Peking Union Medical College, Cancer Institute & Hospital, Chinese Academy of Medical Sciences, Beijing,China.
authors: Yanfeng
authors: Y
authors: Zhao
authors: Department of Diagnostic Radiology, Peking Union Medical College, Cancer Institute & Hospital, Chinese Academy of Medical Sciences, Beijing,China.
authors: Liang
authors: L
authors: Yang
authors: Department of Diagnostic Radiology, Peking Union Medical College, Cancer Institute & Hospital, Chinese Academy of Medical Sciences, Beijing,China.
authors: Lei
authors: L
authors: Hu
authors: Department of Diagnostic Radiology, Peking Union Medical College, Cancer Institute & Hospital, Chinese Academy of Medical Sciences, Beijing,China.
authors: Xinming
authors: X
authors: Zhao
authors: Department of Diagnostic Radiology, Peking Union Medical College, Cancer Institute & Hospital, Chinese Academy of Medical Sciences, Beijing,China.
authors: Chunwu
authors: C
authors: Zhou
mesh_terms: D019540:Area Under Curve; D059248:Chemoradiotherapy; D003131:Combined Modality Therapy; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000000981:diagnostic imaging* / Q000628:therapy*; D007089:Image Enhancement / Q000379:methods; D007822:Laryngeal Neoplasms / Q000000981:diagnostic imaging* / Q000628:therapy*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012372:ROC Curve; D016896:Treatment Outcome
keywords: Chemo-radiotherapy; Dynamic contrast-enhanced magnetic resonance imaging; Larynx and hypopharynx carcinoma; Semi-quantitative parameters