title: Clinical Laboratory Testing in the Era of Directly Acting Antiviral Therapies for Hepatitis C.
abstract: Directly acting antiviral (DAA) combination therapies for chronic hepatitis C virus (HCV) infection are highly effective, but treatment decisions remain complex. Laboratory testing is important to evaluate a range of viral, host, and pharmacological factors when considering HCV treatment, and patients must be monitored during and after therapy for safety and to assess the viral response. In this review, we discuss the laboratory tests relevant for the treatment of HCV infection in the era of DAA therapy, grouped according to viral and host factors.
authors: Institute of Human Virology, University of Maryland School of Medicine, University of Maryland, Baltimore, Maryland, USA.|Critical Care Medicine Department of the NIH Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.
authors: Eleanor M
authors: EM
authors: Wilson
authors: Critical Care Medicine Department of the NIH Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.
authors: Elana S
authors: ES
authors: Rosenthal
authors: Institute of Human Virology, University of Maryland School of Medicine, University of Maryland, Baltimore, Maryland, USA.|Critical Care Medicine Department of the NIH Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.
authors: Sarah
authors: S
authors: Kattakuzhy
authors: Institute of Human Virology, University of Maryland School of Medicine, University of Maryland, Baltimore, Maryland, USA.
authors: Lydia
authors: L
authors: Tang
authors: Institute of Human Virology, University of Maryland School of Medicine, University of Maryland, Baltimore, Maryland, USA skottilil@ihv.umaryland.edu.|National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
authors: Shyam
authors: S
authors: Kottilil
mesh_terms: D000998:Antiviral Agents / Q000494:pharmacology / Q000627:therapeutic use*; D000066491:Clinical Decision-Making; D024882:Drug Resistance, Viral / Q000187:drug effects; D016174:Hepacivirus / Q000187:drug effects* / Q000502:physiology; D019698:Hepatitis C, Chronic / Q000188:drug therapy* / Q000821:virology; D006801:Humans; D019562:Viral Load / Q000187:drug effects
chemical_list: D000998:Antiviral Agents
keywords: directly acting antiviral therapy; hepatitis C virus; viral resistance