title: Complete response to paclitaxel, ifosfamide, and cisplatin therapy in a case of ovarian ependymoma.
abstract: There are many reports on paclitaxel, ifosfamide, and cisplatin (TIP) therapy, following standard bleomycin, etoposide, and cisplatin (BEP) therapy, for salvage treatment of testicular malignant germ cell tumors, but there are no reports on its use for ovarian malignant tumors. We report here that a patient with primary ependymoma of the ovary, who was resistant to BEP therapy, achieved a complete response to a combined therapy, including TIP therapy as the second-line chemotherapy and surgery. This important case, combined with published studies, suggests that TIP therapy is effective for both testicular and ovarian malignant tumors and indicates that TIP therapy can be used as an effective second-line therapy for malignant tumors resistant to BEP therapy.
authors: Department of Obstetrics and Gynecology, National Hospital Organization Saitama National Hospital, Saitama, Japan. makihino@wakho.hosp.go.jp.
authors: Makiko
authors: M
authors: Hino
authors: Department of Obstetrics and Gynecology, National Hospital Organization Saitama National Hospital, Saitama, Japan.|Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.
authors: Yusuke
authors: Y
authors: Kobayashi
authors: Department of Obstetrics and Gynecology, National Hospital Organization Saitama National Hospital, Saitama, Japan.
authors: Michiko
authors: M
authors: Wada
authors: Department of Obstetrics and Gynecology, National Hospital Organization Saitama National Hospital, Saitama, Japan.
authors: Yoshihisa
authors: Y
authors: Hattori
authors: Department of Obstetrics and Gynecology, National Hospital Organization Saitama National Hospital, Saitama, Japan.
authors: Takashi
authors: T
authors: Kurahasi
authors: Department of Obstetrics and Gynecology, National Hospital Organization Saitama National Hospital, Saitama, Japan.
authors: Hiroyuki
authors: H
authors: Nakagawa
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001761:Bleomycin / Q000627:therapeutic use; D002945:Cisplatin / Q000627:therapeutic use*; D004806:Ependymoma / Q000188:drug therapy* / Q000473:pathology; D005047:Etoposide / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007069:Ifosfamide / Q000627:therapeutic use*; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000473:pathology; D017239:Paclitaxel / Q000627:therapeutic use*; D016879:Salvage Therapy; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000970:Antineoplastic Agents; D001761:Bleomycin; D005047:Etoposide; D017239:Paclitaxel; D002945:Cisplatin; D007069:Ifosfamide
keywords: bleomycin, etoposide, and cisplatin; ependymoma; malignant germ cell tumors; paclitaxel, ifosfamide, and cisplatin; salvage