title: Clinical Charateristics and Outcome of Pyogenic Liver Abscess with Different Size: 15-Year Experience from a Single Center.
abstract: The standard therapeutic protocols of pyogenic liver abscess (PLA) have not been well established yet. We investigated the clinical characteristics, disease progression, choices of treatments and outcomes of PLA with different size. 410 cases of patients with PLA were enrolled retrospectively from 2000 to 2014, and were grouped as small abscess (≤5 cm, n = 125), large abscess (5 cm to 10 cm, n = 218) and giant abscess (>10 cm, n = 36). The most common bacteria were Klebsiella pneumonia (22%) and Escherichia coli (11%) by pus culture, and Escherichia coli (36.7%), gram-positive coccus,(36.7%) and Klebsiella pneumonia (33.3%) by blood culture. 115 patients (28.0%) received antibiotics treatment alone, 161 patients (39.3%) received percutaneous drainage (PD) and 134 patients (32.7%) underwent surgical incision and drainage (SD). The size of abscess was correlated with leukocytes increase, albumin decrease, and time duration for body temperature normalization (all p < 0.05). Antibiotics treatment alone, PD and SD was mainly used in patients with small abscess (42.4%), large abscess (44.0%) and giant abscess (47.2%), respectively. For patients with giant abscess, SD group (n = 17) had higher morbidity than PD group (n = 14) (76.4% vs. 35.7%, p = 0.022). PD might achieve the same curative rate as SD in giant abscess, but with less trauma, lower morbidity and shorter hospital stay.
authors: Department of Hepatobiliary Surgery, the First Affiliated Hospital Xi'an Jiaotong University, Xi'an, 710061, Shaanxi Province, China.|Institute of Advanced Surgical Technology and Engineering, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi Province, China.|Shaanxi Provincial Regenerative Medicine and Surgical Engineering Research Center Xi'an, 710061, Shaanxi Province, China.
authors: Zhao-Qing
authors: ZQ
authors: Du
authors: Department of Pharmacy, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, Shaanxi Province, China.
authors: Li-Na
authors: LN
authors: Zhang
authors: Department of Hepatobiliary Surgery, the First Affiliated Hospital Xi'an Jiaotong University, Xi'an, 710061, Shaanxi Province, China.|Institute of Advanced Surgical Technology and Engineering, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi Province, China.|Shaanxi Provincial Regenerative Medicine and Surgical Engineering Research Center Xi'an, 710061, Shaanxi Province, China.
authors: Qiang
authors: Q
authors: Lu
authors: Department of Hepatobiliary Surgery, the First Affiliated Hospital Xi'an Jiaotong University, Xi'an, 710061, Shaanxi Province, China.|Institute of Advanced Surgical Technology and Engineering, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi Province, China.|Shaanxi Provincial Regenerative Medicine and Surgical Engineering Research Center Xi'an, 710061, Shaanxi Province, China.
authors: Yi-Fan
authors: YF
authors: Ren
authors: Department of Hepatobiliary Surgery, the First Affiliated Hospital Xi'an Jiaotong University, Xi'an, 710061, Shaanxi Province, China.|Institute of Advanced Surgical Technology and Engineering, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi Province, China.|Shaanxi Provincial Regenerative Medicine and Surgical Engineering Research Center Xi'an, 710061, Shaanxi Province, China.
authors: Yi
authors: Y
authors: Lv
authors: Department of Hepatobiliary Surgery, the First Affiliated Hospital Xi'an Jiaotong University, Xi'an, 710061, Shaanxi Province, China.|Institute of Advanced Surgical Technology and Engineering, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi Province, China.|Shaanxi Provincial Regenerative Medicine and Surgical Engineering Research Center Xi'an, 710061, Shaanxi Province, China.
authors: Xue-Min
authors: XM
authors: Liu
authors: Department of Hepatobiliary Surgery, the First Affiliated Hospital Xi'an Jiaotong University, Xi'an, 710061, Shaanxi Province, China.|Institute of Advanced Surgical Technology and Engineering, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi Province, China.|Shaanxi Provincial Regenerative Medicine and Surgical Engineering Research Center Xi'an, 710061, Shaanxi Province, China.
authors: Xu-Feng
authors: XF
authors: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D001419:Bacteria / Q000145:classification / Q000302:isolation & purification; D001424:Bacterial Infections / Q000473:pathology / Q000628:therapy; D002648:Child; D002675:Child, Preschool; D004322:Drainage; D005260:Female; D005658:Fungi / Q000145:classification / Q000302:isolation & purification; D006801:Humans; D007223:Infant; D046290:Liver Abscess, Pyogenic / Q000473:pathology* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009181:Mycoses / Q000473:pathology / Q000628:therapy; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000890:Anti-Infective Agents