title: [Expression and Clinical Significance of N-cadherin in Bone Marrow Leukemic Cells Derived from Patients with Acute Leukemia].
abstract: OBJECTIVE
  To investigate the expression of N-cadherin in bone marrow leukemic cells derived from acute leukemia patients and its clinical significances.
  
  
  METHODS
  A total of 113 patients with acute leukemia were enrolled in this study. Flow cytometry was employed to detect the expression of N-Cadherin in bone marrow leukemic cells from acute leukemia patients and the relationships between the N-cadherin expression and the clinical characteristics of patients with acute leukemia were analyzed.
  
  
  RESULTS
  The expression of N-Cadherin in bone marrow leukemic cells deriveted from patients with acute leukemia was variable with 0%-99.7%. For adult AML patients, the positive rate of CD34 in N-cadherin+group was significantly higher than that in N-cadherin-group(67.39% vs 33.33%)(P=0.013), while the differences of total CR rate and rate of CR after 1 cycle of induction treatment were not significant between these 2 groups(P>0.05). As to ALL patients, N-cadherin+group had significant lower WBC count (21.31±7.07 vs 51.10±23.69)(P=0.008) and lower percentage of peripheral blood blast (43.22±5.75% vs 66.45±5.65%)(P=0.015). The CR rate after 1 cycle of induction treatment and rate of overall CR were lower and the relapse rate was higher in N-cadherin+ALL group than those in N-cadherin-ALL group, but the differences were not significant (P>0.05). For childhood ALL, the positive rate of CD33 in N-cadherin+group was significantly higher than that in N-cadherin-group(47.62% vs 0%)(P=0.012). The relapse rate was higher in N-cadherin+group than that in N-cadherin-group (30.00% vs 0%)(P=0.115). The median survival time, 3-year overall OS rate and 3-year relapse-free survival rate in N-cadherin-groups of adult AML, non-M3 AML, ALL and chidhood ALL paients were superior to N-cadherin+groups, but the differences were not significant.
  
  
  CONCLUSIONS
  The expression of N-cadherin in bone marrow leukemic cells relates to some clinical features of patients with acute leukemia and to some extent has inferior effect on survival of patients with acute leukemia.
authors: Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China. E-mail: majie318@163.com.cn.
authors: Jie
authors: J
authors: Ma
authors: Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China.
authors: Ya-Jie
authors: YJ
authors: Liu
authors: Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China.
authors: Qiu-Tang
authors: QT
authors: Zhang
authors: Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China.
authors: Qing-Feng
authors: QF
authors: Yu
authors: Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China.
authors: Zhan-Fang
authors: ZF
authors: Zhang
authors: Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China.
authors: Meng-Ying
authors: MY
authors: Zhang
authors: Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China.
authors: Chong
authors: C
authors: Wang
authors: Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China.
authors: Si-Lin
authors: SL
authors: Gan
authors: Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China.
authors: Sheng-Mei
authors: SM
authors: Chen
authors: Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China.
authors: Wei-Jie
authors: WJ
authors: Cao
authors: Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China.
authors: Xin-Sheng
authors: XS
authors: Xie
authors: Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China.
authors: Liu
authors: L
authors: Yan-Fang
authors: Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China.
authors: Lin-Xiang
authors: LX
authors: Liu
authors: Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China.
authors: Ding-Ming
authors: DM
authors: Wan
authors: Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China.
authors: Fang
authors: F
authors: Wang
authors: Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China.
authors: Ling
authors: L
authors: Sun
authors: Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China.
authors: Hui
authors: H
authors: Sun
mesh_terms: D000208:Acute Disease; D001853:Bone Marrow; D001854:Bone Marrow Cells; D015820:Cadherins; D005434:Flow Cytometry; D006403:Hematologic Tests; D006801:Humans; D015470:Leukemia, Myeloid, Acute; D011379:Prognosis; D012008:Recurrence; D015996:Survival Rate
chemical_list: D015820:Cadherins