title: Association of Dystrobrevin-Binding Protein 1 Polymorphisms with Sustained Attention and Set-Shifting in Schizophrenia Patients.
abstract: BACKGROUND
  Despite extensive research in the past decades, the influence of genetics on cognitive functions in schizophrenia remains unclear. Dystrobrevin-binding protein 1 (DTNBP1) is one of the most promising candidate genes in schizophrenia. An association of DTNBP1 with cognitive dysfunction, particularly memory impairment, has been reported in a number of studies. However, the results remain inconsistent. The aim of this study was to measure the association between DTNBP1 polymorphisms and cognitive domains in a well-characterized sample.
  
  
  METHODS
  Ninety-one clinically stable schizophrenia outpatients underwent a battery of cognitive tests. Six single nucleotide polymorphisms (SNPs) of DTNBP1 were genotyped in all participants. Statistical and multivariate analyses were performed.
  
  
  RESULTS
  Factor analysis revealed 4 factors corresponding to distinct cognitive domains, namely sustained attention, set-shifting, executive functioning, and memory. We found a significant association of the rs909706 polymorphism with attention (p = 0.030) and a nonsignificant trend for set-shifting (p = 0.060). The other SNPs and haplotypes were not associated with cognitive function.
  
  
  CONCLUSIONS
  Replication of this finding in a larger sample is needed in order to confirm the importance of this particular polymorphism in the genetics of schizophrenia, particularly the distinct cognitive domains. In conclusion, the present study supports the involvement of DTNBP1 in the regulation of cognitive processes and demonstrates association in particular with sustained attention and set-shifting in schizophrenia patients.
authors: Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité University Medicine, Berlin, Germany.
authors: George
authors: G
authors: Bakanidze
authors: Eva J
authors: EJ
authors: Brandl
authors: Christine
authors: C
authors: Hutzler
authors: Friederike
authors: F
authors: Aurass
authors: Silke
authors: S
authors: Onken
authors: Michael A
authors: MA
authors: Rapp
authors: Imke
authors: I
authors: Puls
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001288:Attention; D003072:Cognition Disorders / Q000235:genetics* / Q000523:psychology; D000074765:Dysbindin; D049029:Dystrophin-Associated Proteins / Q000235:genetics*; D056344:Executive Function; D005163:Factor Analysis, Statistical; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008568:Memory; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000235:genetics*; D012565:Schizophrenic Psychology; D055815:Young Adult
chemical_list: C432416:DTNBP1 protein, human; D000074765:Dysbindin; D049029:Dystrophin-Associated Proteins