title: Component Analysis of Laryngeal Cancer Incidence Dynamics in Kazakhstan from 1999 to 2014.
abstract: BACKGROUND
  In this study, we examined epidemiological aspects of dynamic changes in incidences of laryngeal cancer in male and female populations in Kazakhstan.
  
  
  METHODS
  Primary data were for registered patients with malignant laryngeal tumors in the whole country during the period of 1999-2014. Evaluation of changes in laryngeal cancer incidence in the population of Kazakhstan was performed using component analysis.
  
  
  RESULTS
  It was determined that the number of patients with laryngeal cancer in the whole country is decreasing although with conflicting impacts of different factors. Despite population growth (all - ΔP=+66.1%, men - ΔP=+70.9% and women - ΔP=+46.4%), and aging (all - ΔA=+45.1%, men -ΔA=+54.3 and women - ΔA=+22.2), the reduction in risk of developing the disease (all - ΔR=-165.6%, men - ΔR=-170.9% and women - ΔR=-141.0%) was overwhelming.
  
  
  CONCLUSIONS
  This investigation was the first epidemiological study of dynamics of laryngeal cancer by component analysis in the population of Kazakhstan. Implementation of the results of the study is recommended in management of anti-cancer activities for laryngeal cancer.
authors: Central Asian Cancer Institute, Astana, Kazakhstan E-mail : n.igissinov@gmail.com; www.cancer.kz.
authors: Vera
authors: V
authors: Zatonskikh
authors: Nurbek
authors: N
authors: Igissinov
authors: Saginbek
authors: S
authors: Igissinov
authors: Gulnur
authors: G
authors: Igissinova
authors: Zarina
authors: Z
authors: Bilyalova
authors: Dariyana
authors: D
authors: Kulmirzayeva
authors: Anatoliy
authors: A
authors: Venglovskiy
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D005260:Female; D006801:Humans; D015994:Incidence; D007623:Kazakhstan / Q000453:epidemiology; D007822:Laryngeal Neoplasms / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D055815:Young Adult