title: Protective Effects of Adenosine Receptor Agonist in a Cirrhotic Liver Resection Model.
abstract: OBJECTIVE
  To investigate the role of CGS21680, a selective adenosine A2A receptor agonist, on a bile-duct-ligated cirrhotic liver resection model in rats.
  
  
  METHODS
  Male Wistar rats were allotted into 3 groups (n = 7 per time-point): the control group, the bile duct ligation + CGS21680 group (BDL + CGS), and the bile duct ligation group (BDL). Biliary cirrhosis had been previously induced by ligature of the common bile duct in the BDL + CGS and BDL groups. After 2 weeks, the animals underwent partial hepatectomy (50%). The BDL + CGS group received a single dose of CGS21680 15 minutes prior to hepatectomy. Blood samples were collected and analyzed.
  
  
  RESULTS
  Aspartate transaminase levels were found to be lower in the control vs BDL groups (1, 3, and 24 h) (P < 0.01) and the BDL + CGS (1 and 3 hours) (P < 0.01) and BDL + CGS vs BDL (24 hours) (P < 0.05) groups. Hepatic flow was measured and BDL showed significantly lower values at the 3, 24, and 168 h time-points compared to the control (P < 0.01) and BDL + CGS groups (P < 0.05 at 3 and 168 hours; P < 0.01 at 24 h). O2C velocity was reduced in the BDL compared to the control group (P < 0.001 at 3 hours; P < 0.01 at 24 and 168 hours) and the BDL + CGS group (P < 0.01 at 24 hours). Interleukin-6 levels were abrogated in the BDL + CGS (P < 0.05) and control (P < 0.01) groups versus BDL. Histone-bound low-molecular-weight DNA fragments in the BDL + CGS (P < 0.01) and control (P < 0.05) groups were low compared to the BDL group.
  
  
  CONCLUSIONS
  Administration of CGS21680, an adenosine receptor agonist, after the resection of bile-duct-ligated cirrhotic livers led to improved liver function, regeneration, and microcirculation.
authors: Department of Hepato-biliary and Pancreas Surgery, Scientific Center of Surgery named after academician M.A.Topchubashov, Baku, Azerbaijan.
authors: Emil
authors: E
authors: Iskandarov
authors: Institute for Laboratory Animal Science and Experimental Surgery, University Hospital, RWTH Aachen University, Aachen, Germany.
authors: Pramod
authors: P
authors: Kadaba Srinivasan
authors: Tongji Hospital, Tongji Medical College, Department of Surgery, Division of Transplantation, Wuhan, China.
authors: Wang
authors: W
authors: Xin
authors: Department of Anaesthesiology, University Hospital, RWTH Aachen University, Aachen, Germany.
authors: Christian
authors: C
authors: Bleilevens
authors: Institute for Laboratory Animal Science and Experimental Surgery, University Hospital, RWTH Aachen University, Aachen, Germany.
authors: Mamdouh
authors: M
authors: Afify
authors: Department of Abdominal Surgery, University Clinical Center of Kosovo, Prishtina, Kosovo.
authors: Astrit
authors: A
authors: Hamza
authors: Tongji Hospital, Tongji Medical College, Department of Surgery, Division of Transplantation, Wuhan, China.
authors: Lai
authors: L
authors: Wei
authors: Department of Hepatobiliary, Pancreas and Transplant Surgery, Kyoto University, Yoshidahonmachi, Sakyo Ward, Kyoto, Japan.
authors: Koichiro
authors: K
authors: Hata
authors: Department of Hepato-biliary and Pancreas Surgery, Scientific Center of Surgery named after academician M.A.Topchubashov, Baku, Azerbaijan.
authors: Boyukkishi
authors: B
authors: Agayev
authors: Institute for Laboratory Animal Science and Experimental Surgery, University Hospital, RWTH Aachen University, Aachen, Germany.
authors: Rene
authors: R
authors: Tolba
keywords: A2A Adenosine Receptors; CGS21680; Interleukin-6; liver Cirrhosis; liver Resection