title: Ultralow-Power Near Infrared Lamp Light Operable Targeted Organic Nanoparticle Photodynamic Therapy.
abstract: Tissue penetration depth is a major challenge in practical photodynamic therapy (PDT). A biocompatible and highly effective near infrared (NIR)-light-absorbing carbazole-substituted BODIPY (Car-BDP) molecule is reported as a class of imaging-guidable deep-tissue activatable photosensitizers for PDT. Car-BDP possesses an intense, broad NIR absorption band (600-800 nm) with a remarkably high singlet oxygen quantum yield (ΦΔ= 67%). After being encapsulated with biodegradable PLA-PEG-FA polymers, Car-BDP can form uniform and small organic nanoparticles that are water-soluble and tumor-targetable. Rather than using laser light, such nanoparticles offer an unprecedented deep-tissue, tumor targeting photodynamic therapeutic effect by using an exceptionally low-power-density and cost-effective lamp light (12 mW cm-2). In addition, these nanoparticles can be simultaneously traced in vivo due to their excellent NIR fluorescence. This study signals a major step forward in photodynamic therapy by developing a new class of NIR-absorbing biocompatible organic nanoparticles for effective targeting and treatment of deep-tissue tumors. This work also provides a potential new platform for precise tumor-targeting theranostics and novel opportunities for future affordable clinical cancer treatment.
authors: Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School , Worcester, Massachusetts 01605, United States.|State Key Laboratory of Fine Chemicals, School of Chemical Engineering, Dalian University of Technology , E-208 West Campus, 2 Ling-Gong Road, Dalian 116024, P. R. China.
authors: Ling
authors: L
authors: Huang
authors: Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School , Worcester, Massachusetts 01605, United States.
authors: Zhanjun
authors: Z
authors: Li
authors: Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School , Worcester, Massachusetts 01605, United States.|Department of Radiology, The Second Hospital of Tianjin Medical University , Tianjin, 300211 China.
authors: Yang
authors: Y
authors: Zhao
authors: Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School , Worcester, Massachusetts 01605, United States.
authors: Yuanwei
authors: Y
authors: Zhang
authors: State Key Laboratory of Fine Chemicals, School of Chemical Engineering, Dalian University of Technology , E-208 West Campus, 2 Ling-Gong Road, Dalian 116024, P. R. China.
authors: Shuang
authors: S
authors: Wu
authors: State Key Laboratory of Fine Chemicals, School of Chemical Engineering, Dalian University of Technology , E-208 West Campus, 2 Ling-Gong Road, Dalian 116024, P. R. China.
authors: Jianzhang
authors: J
authors: Zhao
authors: Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School , Worcester, Massachusetts 01605, United States.
authors: Gang
authors: G
authors: Han
mesh_terms: D001681:Biological Assay; D001896:Boron Compounds / Q000737:chemistry; D002470:Cell Survival; D006367:HeLa Cells; D006801:Humans; D007259:Infrared Rays; D015394:Molecular Structure; D061848:Optical Imaging; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000737:chemistry / Q000191:economics / Q000494:pharmacology; D011878:Radiotherapy / Q000379:methods*; D014867:Water / Q000737:chemistry
chemical_list: C095489:4,4-difluoro-4-bora-3a,4a-diaza-s-indacene; D001896:Boron Compounds; D017319:Photosensitizing Agents; D014867:Water