title: Physical activity and long-term mortality risk in older adults: A prospective population based study (NEDICES).
abstract: To analyze whether Physical activity (PA) reduces mortality risk at thirteen years' follow-up in a population-based cohort of Spanish older adults. The NEDICES (Neurological Disorders in Central Spain) is a prospective population-based survey of older adults (age ≥ 65 years) that comprised 5278 participants at baseline. A modified version of the Rosow-Breslau questionnaire was applied to categorize the PA (sedentary, light, moderate and high) and dates of death were collected from the Official Spanish Death Registry. Cox regression models adjusted for different covariates (age, sex, marital status, smoking, previous stroke, Parkinson disease, incident dementia, body mass index, comorbidity indexes and functional assessment) were used to evaluate the hazard of death at thirteen years' interval according to different levels of PA. 1710 deaths (52.9% men vs. 47.1% women) were identified among 3633 individuals at thirteen years' follow-up. Hazard ratios (HRs) of the light, moderate, and high PA groups (vs. sedentary group) were 0.64 (95% confidence interval (CI) [0.56, 0.72], p < 0.001), 0.61 (95% CI [0.53, 0.70], p < 0.001) and 0.48 (95% CI [0.41, 0.55], p < 0.001), respectively. Significant dose effects were observed between light versus the sedentary group and intense versus the moderate group. PA prevents long-term mortality in older Spanish adults, with the highest intensity levels being those related to the lowest risk of mortality. These findings indicate that health policies for old age care should include PA as one of the main targets.
authors: Department of Neurology, University Hospital "12 de Octubre", Madrid, Spain; Unit of Clinical Research, Research Institute of the "Hospital 12 de Octubre" (I + 12), Madrid, Spain; The Biomedical Research Centre Network for Neurodegenerative disease (CIBERNED), Carlos III Research Institute, Madrid, Spain.
authors: Sara
authors: S
authors: Llamas-Velasco
authors: Department of Neurology, University Hospital "12 de Octubre", Madrid, Spain; Unit of Clinical Research, Research Institute of the "Hospital 12 de Octubre" (I + 12), Madrid, Spain; The Biomedical Research Centre Network for Neurodegenerative disease (CIBERNED), Carlos III Research Institute, Madrid, Spain.
authors: Alberto
authors: A
authors: Villarejo-Galende
authors: Department of Basic Psychology, Psychobiology and Methodology of Behavioral Science, University of Salamanca, Salamanca, Spain.
authors: Israel
authors: I
authors: Contador
authors: Unit of Clinical Research, Research Institute of the "Hospital 12 de Octubre" (I + 12), Madrid, Spain.
authors: David
authors: D
authors: Lora Pablos
authors: Department of Neurology, University Hospital "12 de Octubre", Madrid, Spain; Unit of Clinical Research, Research Institute of the "Hospital 12 de Octubre" (I + 12), Madrid, Spain; The Biomedical Research Centre Network for Neurodegenerative disease (CIBERNED), Carlos III Research Institute, Madrid, Spain.
authors: Jesús
authors: J
authors: Hernández-Gallego
authors: Unit of Clinical Research, Research Institute of the "Hospital 12 de Octubre" (I + 12), Madrid, Spain; The Biomedical Research Centre Network for Epidemiology and Public Health (CIBERESP), Carlos III Research Institute, Madrid, Spain; Extraordinaire Chair of Alzheimer and Neurodegenerative Diseases, Department of Medicine, Complutense University, Madrid, Spain.
authors: Félix
authors: F
authors: Bermejo-Pareja
keywords: Aging; Health; Mortality; Physical activity; Population-based study