title: "Genetic regulation of Mycobacterium tuberculosis in a lipid-rich environment".
abstract: Tuberculosis (TB) remains as one of the leading causes of morbidity and mortality among infectious diseases worldwide. Although lipids (mainly fatty acids and cholesterol) have been reported to play an important role during active and latent infection of M. tuberculosis, there are other molecular aspects of bacterial response to those substrates that are not fully understood, involving gene regulation background. This review highlights recent insights on pathogen gene expression: regulation during its active growth, during survival in presence of lipids and under variable hostile host microenvironments. We also propose several application options of this knowledge that may contribute for improved TB control.
authors: Departamento de Microbiologia, Escuela Nacional de Ciencias Biologicas, Instituto Politecnico Nacional, Prolongacion de Carpio y Plan de Ayala S/N, Mexico City, Mexico; Department of Biochemistry and Microbiology, Faculty of Sciences, Ghent University, K.L. Ledeganckstraat 35, B-9000 Ghent, Belgium.
authors: Diana A
authors: DA
authors: Aguilar-Ayala
authors: Department of Biochemistry and Microbiology, Faculty of Sciences, Ghent University, K.L. Ledeganckstraat 35, B-9000 Ghent, Belgium.
authors: Juan Carlos
authors: JC
authors: Palomino
authors: Department of Biochemistry and Microbiology, Faculty of Sciences, Ghent University, K.L. Ledeganckstraat 35, B-9000 Ghent, Belgium.
authors: Peter
authors: P
authors: Vandamme
authors: Department of Biochemistry and Microbiology, Faculty of Sciences, Ghent University, K.L. Ledeganckstraat 35, B-9000 Ghent, Belgium. Electronic address: anandi.martin@ugent.be.
authors: Anandi
authors: A
authors: Martin
authors: Departamento de Microbiologia, Escuela Nacional de Ciencias Biologicas, Instituto Politecnico Nacional, Prolongacion de Carpio y Plan de Ayala S/N, Mexico City, Mexico; Red Multidisciplinaria de Investigación en Tuberculosis, Mexico. Electronic address: jgonzal1212@yahoo.com.mx.
authors: Jorge A
authors: JA
authors: Gonzalez-Y-Merchand
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D015964:Gene Expression Regulation, Bacterial; D006099:Granuloma; D006801:Humans; D006863:Hydrogen-Ion Concentration; D000860:Hypoxia; D050356:Lipid Metabolism; D051379:Mice; D009169:Mycobacterium tuberculosis / Q000235:genetics* / Q000378:metabolism*; D013312:Stress, Physiological; D014376:Tuberculosis / Q000382:microbiology*
keywords: M. tuberculosis; M. tuberculosis gene expression; M. tuberculosis lipids; M. tuberculosis microenvironments; M. tuberculosis stress responses