title: Periodontitis is not associated with metabolic risk during the fourth decade of life.
abstract: To examine associations between periodontitis and developmental trajectories of glycated haemoglobin (HbA1c) during the third and fourth decades in an initially healthy sample.
  
  
  
  HbA1c data collected at ages 26, 32 and 38 in the prospective Dunedin Multidisciplinary Health and Development Study were used to assign study members (n = 893) to trajectories applying group-based trajectory modelling (GBTM). The model allowed the statistical linking of baseline demographic, smoking and waist-height ratio covariates to group membership probability; and added a time-varying covariate (periodontitis) to the trajectories themselves to examine whether events that occurred during the course of the trajectory altered its course.
  
  
  
  Three HbA1c trajectory groups were identified: "Low" (n = 98, 11.0%); "Medium" (n = 482, 54.0%); and "High" (n = 313, 35.0%) with mean HbA1c of 29.6, 34.1 and 38.7 mmol/mol, respectively, at age 38. Having periodontitis at 32 and 38 was associated with an upward shift in the trajectories. However, none of the associations were statistically significant.
  
  
  
  Periodontitis was not found to be associated with dysglycaemia over 12 years from early adulthood into early middle age. This suggests that any influence periodontitis may have on dysglycaemia develops later in life.
authors: Department of Oral Sciences, Faculty of Dentistry, University of Otago, Dunedin, New Zealand.
authors: Dara M
authors: DM
authors: Shearer
authors: Department of Oral Sciences, Faculty of Dentistry, University of Otago, Dunedin, New Zealand.
authors: W Murray
authors: WM
authors: Thomson
authors: Department of Oral Rehabilitation, Faculty of Dentistry, University of Otago, Dunedin, New Zealand.
authors: Jonathan M
authors: JM
authors: Broadbent
authors: Department of Human Nutrition, University of Otago, Dunedin, New Zealand.|Edgar National Centre for Diabetes and Obesity Research, Dunedin, New Zealand.
authors: Jim
authors: J
authors: Mann
authors: Dunedin Multidisciplinary Health and Development Research Unit, University of Otago, Dunedin, New Zealand.
authors: Richie
authors: R
authors: Poulton
mesh_terms: D000328:Adult; D000367:Age Factors; D005260:Female; D044882:Glucose Metabolism Disorders / Q000097:blood / Q000150:complications; D006442:Glycated Hemoglobin / Q000032:analysis*; D006801:Humans; D008297:Male; D010518:Periodontitis / Q000097:blood* / Q000453:epidemiology / Q000209:etiology; D011446:Prospective Studies
chemical_list: D006442:Glycated Hemoglobin
keywords: glycated haemoglobin; longitudinal; periodontitis; smoking; type 2 diabetes; waist-height ratio