title: Single-Nucleotide Polymorphism rs17611 of Complement Component 5 Shows Association with Ischemic Stroke in Northeast Chinese Population.
abstract: BACKGROUND
  Complement component 5 (C5) has been described to play an important role in the development and progression of atherosclerosis and cardiovascular disease. Our aim was to determine whether genetic variation of C5 was associated with ischemic stroke (IS) in northeast Chinese population.
  
  
  METHODS
  We used a case-control study involving 386 IS patients and 386 non-IS controls from a rural population and determined the genotypes of five polymorphisms (rs12237774, rs17611, rs4837805, rs7026551, and rs1017119) of C5 gene by Snapshot single-nucleotide polymorphism genotyping assays to assess any links with IS.
  
  
  RESULTS
  In univariate analysis, rs17611 was significantly associated with IS in the additive model, the dominant model, and recessive model (additive p 0.031, dominant p 0.034, and recessive p 0.027). After adjustment for Binary Logistic Regression, rs17611 polymorphism was still significant in three models (adjusted odds ratio (OR) = 1.306, 95% confidence interval (CI) = 1.069-1.595, p-value = 0.009 in an additive model; OR = 1.378, 95% CI = 1.024-1.856, p-value = 0.035 in a dominant model; and OR = 1.511, 95% CI = 1.048-2.18, p-value = 0.027 in a recessive model).
  
  
  CONCLUSIONS
  In this sample of patients, genetic variation of rs17611 in C5 is associated with higher prevalence of IS.
authors: 1 Department of Cardiology, The First Hospital of China Medical University , Shenyang, People's Republic of China .
authors: Liang
authors: L
authors: Guo
authors: 2 Department of Clinical Epidemiology, Shengjing Hospital of China Medical University , Shenyang, People's Republic of China .
authors: Liqiang
authors: L
authors: Zheng
authors: 1 Department of Cardiology, The First Hospital of China Medical University , Shenyang, People's Republic of China .
authors: Xiaofan
authors: X
authors: Guo
authors: 1 Department of Cardiology, The First Hospital of China Medical University , Shenyang, People's Republic of China .
authors: Ye
authors: Y
authors: Chang
authors: 1 Department of Cardiology, The First Hospital of China Medical University , Shenyang, People's Republic of China .
authors: Xinghu
authors: X
authors: Zhou
authors: 1 Department of Cardiology, The First Hospital of China Medical University , Shenyang, People's Republic of China .
authors: Yingxian
authors: Y
authors: Sun
mesh_terms: D000368:Aged; D000483:Alleles; D044466:Asian People / Q000235:genetics; D050197:Atherosclerosis / Q000235:genetics; D016022:Case-Control Studies; D003182:Complement C5 / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D014644:Genetic Variation; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D012424:Rural Population; D020521:Stroke / Q000235:genetics*
chemical_list: D003182:Complement C5
keywords: complement component 5; ischemic stroke; single-nucleotide polymorphism