title: Is biological aging accelerated in drug addiction?
abstract: Drug-addiction may trigger early onset of age-related disease, due to drug-induced multi-system toxicity and perilous lifestyle, which remains mostly undetected and untreated. We present the literature on pathophysiological processes that may hasten aging and its relevance to addiction, including: oxidative stress and cellular aging, inflammation in periphery and brain, decline in brain volume and function, and early onset of cardiac, cerebrovascular, kidney, and liver disease. Timely detection of accelerated aging in addiction is crucial for the prevention of premature morbidity and mortality.
authors: Department of Psychiatry & Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY.
authors: Keren
authors: K
authors: Bachi
authors: Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY.
authors: Salvador
authors: S
authors: Sierra
authors: The National Institute on Drug Abuse, Bethesda, MD.
authors: Nora D
authors: ND
authors: Volkow
authors: Department of Psychiatry & Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY.
authors: Rita Z
authors: RZ
authors: Goldstein
authors: Department of Psychiatry & Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY.
authors: Nelly
authors: N
authors: Alia-Klein