title: Possible role of IL-6 and TIE2 gene polymorphisms in predicting the initial high transport status in patients with peritoneal dialysis: an observational study.
abstract: The aim of this study was to investigate the effect of interleukin (IL)-6 and TIE2 gene polymorphisms on baseline peritoneal transport property.
  
  
  
  An observational study.
  
  
  
  Renji Hospital in Shanghai, China.
  
  
  
  This study included 220 patients with continuous ambulatory peritoneal dialysis (PD).
  
  
  
  Patients were divided into 2 groups based on the results of an initial peritoneal equilibration test performed within 3 months of starting PD therapy: group 1 consisted of low/low average transporters (n=123), and group 2 consisted of high/high average transporters (n=97). We genotyped TIE2 and IL-6 polymorphisms and analysed their effects on baseline transport status.
  
  
  
  The genotype AT in IL-6 Rs13306435 and the genotype CC in TIE2 Rs639225 were both negatively associated with a higher initial peritoneal transport status (IL-6 Rs13306435: OR=0.408, 95% CI 0.227 to 0.736; TIE2 Rs639225: OR=0.188, 95% CI 0.044 to 0.806).
  
  
  
  IL-6 and TIE2 polymorphisms are associated with baseline peritoneal transport property.
authors: Department of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
authors: Li
authors: L
authors: Ding
authors: Department of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
authors: Xinghua
authors: X
authors: Shao
authors: Department of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
authors: Liou
authors: L
authors: Cao
authors: Department of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
authors: Wei
authors: W
authors: Fang
authors: Department of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
authors: Hao
authors: H
authors: Yan
authors: Department of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
authors: Jiaying
authors: J
authors: Huang
authors: Department of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
authors: Aiping
authors: A
authors: Gu
authors: Department of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
authors: Zanzhe
authors: Z
authors: Yu
authors: Department of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
authors: Chaojun
authors: C
authors: Qi
authors: Department of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
authors: Xinbei
authors: X
authors: Chang
authors: Department of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
authors: Zhaohui
authors: Z
authors: Ni
mesh_terms: D000328:Adult; D000368:Aged; D002681:China; D005260:Female; D005838:Genotype; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics*; D007668:Kidney / Q000473:pathology; D007676:Kidney Failure, Chronic / Q000235:genetics* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010530:Peritoneal Dialysis; D010531:Peritoneal Dialysis, Continuous Ambulatory; D010537:Peritoneum / Q000378:metabolism*; D011110:Polymorphism, Genetic; D042787:Receptor, TIE-2 / Q000235:genetics*
chemical_list: C508600:IL6 protein, human; D015850:Interleukin-6; D042787:Receptor, TIE-2
keywords: TIE2; gene polymorphism; high transport status; interleukin-6; peritoneal dialysis