title: Diagnostic Interview for Genetic Studies: validity and reliability of the Croatian version.
abstract: To test the validity and reliability of the Diagnostic Interview for Genetic Studies (DIGS) in patients with mental illness in Croatia.
  
  
  
  Following translation, back-translation, and pilot testing, the Croatian version of DIGS (CRO-DIGS) was administered to a total of 150 inpatients and outpatients diagnosed at the Clinical Hospital in Split with bipolar and major depressive disorder (n=56), schizophrenia and schizoaffective disorder (n=62), and alcohol dependence or use disorders (n=32). Initial testing was performed independently by one interviewer and one observer blinded to the diagnosis, and a retest was performed after 8 weeks by a third examiner.
  
  
  
  The validity of CRO-DIGS was high (κ=0.916), with an excellent inter-rater (κ=0.824) reliability, especially for bipolar disorder (κ=0.956). Following an 8 week test-retest interval, the reliability for all diagnoses was found to be excellent (κ=0.843).
  
  
  
  Our study has shown excellent validity and reliability of the Croatian version of DIGS, making it a promising instrument to assess mental illness of patients. The development of a valid and reliable diagnostic tool such as the CRO-DIGS will considerably advance the scientific communities' ability to carry out genetic studies of psychiatric illness in the region.
authors: aClinic for Psychiatry bClinic for Dermatovenerology, University Hospital Split cPrivate Psychiatric Practice dDepartment for Research in Biomedicine and Health, School of Medicine eDepartment of Psychological Medicine, School of Medicine, University of Split, Split, Croatia fCommunity Health Centre Livno, Livno, Bosnia and Herzegovina gDepartment of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis, Indiana hDepartments of Genetics iPsychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
authors: Žana
authors: Ž
authors: Kralj
authors: Milenka
authors: M
authors: Dedić
authors: Anđela
authors: A
authors: Kovačević
authors: Mario
authors: M
authors: Malički
authors: Jelena
authors: J
authors: Dedić
authors: Marina
authors: M
authors: Pelivan
authors: Dubravka
authors: D
authors: Vuković
authors: Carrie
authors: C
authors: Fisher
authors: Rachel L
authors: RL
authors: Kember
authors: John
authors: J
authors: Nurnberger
authors: Maja
authors: M
authors: Bućan
authors: Dolores
authors: D
authors: Britvić
mesh_terms: D000328:Adult; D000368:Aged; D000437:Alcoholism / Q000235:genetics; D001714:Bipolar Disorder / Q000235:genetics; D017523:Croatia / Q000453:epidemiology; D003865:Major Depressive Disorder / Q000235:genetics; D005260:Female; D005820:Genetic Testing / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales / Q000592:standards*; D011618:Psychotic Disorders / Q000175:diagnosis* / Q000235:genetics*; D015203:Reproducibility of Results; D012559:Schizophrenia / Q000235:genetics