title: Naumovozyma castellii: an alternative model for budding yeast molecular biology.
abstract: Naumovozyma castellii (Saccharomyces castellii) is a member of the budding yeast family Saccharomycetaceae. It has been extensively used as a model organism for telomere biology research and has gained increasing interest as a budding yeast model for functional analyses owing to its amenability to genetic modifications. Owing to the suitable phylogenetic distance to S. cerevisiae, the whole genome sequence of N. castellii has provided unique data for comparative genomic studies, and it played a key role in the establishment of the timing of the whole genome duplication and the evolutionary events that took place in the subsequent genomic evolution of the Saccharomyces lineage. Here we summarize the historical background of its establishment as a laboratory yeast species, and the development of genetic and molecular tools and strains. We review the research performed on N. castellii, focusing on areas where it has significantly contributed to the discovery of new features of molecular biology and to the advancement of our understanding of molecular evolution. Copyright © 2016 John Wiley & Sons, Ltd.
authors: Department of Biology, Genetics group, Lund University, Lund, Sweden.
authors: Ahu
authors: A
authors: Karademir Andersson
authors: Department of Biology, Genetics group, Lund University, Lund, Sweden.
authors: Marita
authors: 0000-0002-3370-2864
authors: M
authors: Cohn
mesh_terms: D019143:Evolution, Molecular; D016681:Genome, Fungal / Q000235:genetics; D008967:Molecular Biology; D010802:Phylogeny; D012440:Saccharomyces / Q000235:genetics / Q000378:metabolism* / Q000502:physiology