title: Vibrational Micro-Spectroscopy of Human Tissues Analysis: Review.
abstract: Vibrational spectroscopy (Infrared (IR) and Raman) and, in particular, micro-spectroscopy and micro-spectroscopic imaging have been used to characterize developmental changes in tissues, to monitor these changes in cell cultures and to detect disease and drug-induced modifications. The conventional methods for biochemical and histophatological tissue characterization necessitate complex and "time-consuming" sample manipulations and the results are rarely quantifiable. The spectroscopy of molecular vibrations using mid-IR or Raman techniques has been applied to samples of human tissue. This article reviews the application of these vibrational spectroscopic techniques for analysis of biological tissue published between 2005 and 2015.
authors: a SCIENT-Research Center for Instrumental Analysis , Tancabesti-Snagov , Romania.
authors: Andrei A
authors: AA
authors: Bunaciu
authors: b Department of Analytical Chemistry and Toxicology , Hanoi University of Pharmacy , Hanoi , Vietnam.
authors: Vu Dang
authors: VD
authors: Hoang
authors: c Pharmaceutical and Medicinal Chemistry Department , Pharmaceutical and Drug Industries Research Division , Egypt.
authors: Hassan Y
authors: HY
authors: Aboul-Enein
mesh_terms: D006801:Humans; D009369:Neoplasms / Q000473:pathology*; D013055:Spectrophotometry, Infrared / Q000295:instrumentation; D013057:Spectrum Analysis / Q000379:methods*; D013059:Spectrum Analysis, Raman / Q000295:instrumentation; D014732:Vibration
keywords: Chemometric methods; FTIR analysis; clinical applications; tissue analysis