title: [Rectal squamous cell carcinoma treatment: Retrospective experience in two French university hospitals, review and proposals].
abstract: After publishing a retrospective series of 23 patients treated for a rectal squamous cell carcinoma with exclusive curative and conservative intent chemoradiation, we aim to propose a review of the literature about this rare tumour. We identified 11 retrospective studies, on 106 patients, treated between 2007 and 2016. Treatment of rectal squamous cell carcinoma should be similar to anal carcinoma, based on exclusive chemoradiation, displaying a 5-year overall survival rate over 80%, while it was 32% in surgical series. Baseline explorations should be similar as for anal carcinoma, with an interest in PET-CT at diagnosis and monitoring, after a delay over 6 weeks after chemoradiation. Intensity-modulated radiotherapy is legitimate, to a prophylactic dose between 36 and 45Gy, and over 54Gy to the tumour. Concomitant chemotherapy should combine an antimetabolite (5-fluorouracil or capecitabine) and mitomycin C, or cisplatin. This treatment seems well tolerated, associated with grade 2 or above toxicity below 30%. Follow-up should be established on anal squamous cell carcinoma schedule, with endoscopic ultrasonography and PET-CT. Rectal squamous cell carcinoma is a rare tumour; it management should be based on anal curative and conservative intent chemoradiation.
authors: Service de radiothérapie, hôpital Tenon, hôpitaux universitaires Est Parisien, 4, rue de la Chine, 75020 Paris, France; Université Paris VI Pierre-et-Marie-Curie, 4, rue de la Chine, 75020 Paris, France. Electronic address: aschernberg@gmail.com.
authors: A
authors: A
authors: Schernberg
authors: Centre hospitalier régional et universitaire de Besançon, 2, place Saint-Jacques, 25000 Besançon, France.
authors: S
authors: S
authors: Servagi-Vernat
authors: Service de radiothérapie, hôpital Tenon, hôpitaux universitaires Est Parisien, 4, rue de la Chine, 75020 Paris, France; Université Paris VI Pierre-et-Marie-Curie, 4, rue de la Chine, 75020 Paris, France.
authors: G
authors: G
authors: Loganadane
authors: Service de radiothérapie, hôpital Tenon, hôpitaux universitaires Est Parisien, 4, rue de la Chine, 75020 Paris, France; Université Paris VI Pierre-et-Marie-Curie, 4, rue de la Chine, 75020 Paris, France.
authors: E
authors: E
authors: Touboul
authors: Centre hospitalier régional et universitaire de Besançon, 2, place Saint-Jacques, 25000 Besançon, France.
authors: J-F
authors: JF
authors: Bosset
authors: Service de radiothérapie, hôpital Tenon, hôpitaux universitaires Est Parisien, 4, rue de la Chine, 75020 Paris, France; Université Paris VI Pierre-et-Marie-Curie, 4, rue de la Chine, 75020 Paris, France.
authors: F
authors: F
authors: Huguet
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D000069287:Capecitabine / Q000008:administration & dosage; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging / Q000401:mortality / Q000628:therapy*; D059248:Chemoradiotherapy; D002945:Cisplatin / Q000008:administration & dosage; D002986:Clinical Trials as Topic; D003125:Colostomy; D003131:Combined Modality Therapy; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D005602:France; D006785:Hospitals, University / Q000706:statistics & numerical data; D006801:Humans; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage; D000072078:Positron Emission Tomography Computed Tomography; D011855:Radiodermatitis / Q000209:etiology; D050397:Radiotherapy, Intensity-Modulated / Q000009:adverse effects; D012004:Rectal Neoplasms / Q000000981:diagnostic imaging / Q000401:mortality / Q000628:therapy*; D012189:Retrospective Studies; D012883:Skin Ulcer / Q000209:etiology; D015996:Survival Rate; D016896:Treatment Outcome
chemical_list: D016685:Mitomycin; D000069287:Capecitabine; D002945:Cisplatin; D005472:Fluorouracil
keywords: Carcinome épidermoïde; Chemoradiotherapy; Chimioradiothérapie; Colostomie; Colostomy; Radiotherapy; Radiothérapie; Rectum; Squamous cell carcinoma