title: Extracellular Vesicles in Chronic Obstructive Pulmonary Disease.
abstract: Chronic obstructive pulmonary disease (COPD) is characterized by the progression of irreversible airflow limitation and is a leading cause of morbidity and mortality worldwide. Although several crucial mechanisms of COPD pathogenesis have been studied, the precise mechanism remains unknown. Extracellular vesicles (EVs), including exosomes, microvesicles, and apoptotic bodies, are released from almost all cell types and are recognized as novel cell-cell communication tools. They have been shown to carry and transfer a wide variety of molecules, such as microRNAs, messenger RNAs, and proteins, which are involved in physiological functions and the pathology of various diseases. Recently, EVs have attracted considerable attention in pulmonary research. In this review, we summarize the recent findings of EV-mediated COPD pathogenesis. We also discuss the potential clinical usefulness of EVs as biomarkers and therapeutic agents for the treatment of COPD.
authors: Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, Tokyo 104-0045, Japan. tskadota@ncc.go.jp.|Division of Respiratory Disease, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo 105-8461, Japan. tskadota@ncc.go.jp.
authors: Tsukasa
authors: T
authors: Kadota
authors: Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, Tokyo 104-0045, Japan. yuugot@gmail.com.|Division of Respiratory Disease, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo 105-8461, Japan. yuugot@gmail.com.
authors: Yu
authors: Y
authors: Fujita
authors: Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, Tokyo 104-0045, Japan. yyoshiok@ncc.go.jp.
authors: Yusuke
authors: Y
authors: Yoshioka
authors: Division of Respiratory Disease, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo 105-8461, Japan. araya@jikei.ac.jp.
authors: Jun
authors: J
authors: Araya
authors: Division of Respiratory Disease, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo 105-8461, Japan. kkuwano@jikei.ac.jp.
authors: Kazuyoshi
authors: K
authors: Kuwano
authors: Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, Tokyo 104-0045, Japan. tochiya@ncc.go.jp.
authors: Takahiro
authors: T
authors: Ochiya
mesh_terms: D017209:Apoptosis / Q000235:genetics; D002450:Cell Communication / Q000235:genetics; D055252:Cell-Derived Microparticles / Q000378:metabolism* / Q000473:pathology; D018450:Disease Progression; D055354:Exosomes / Q000235:genetics / Q000378:metabolism; D000067128:Extracellular Vesicles / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D029424:Pulmonary Disease, Chronic Obstructive / Q000235:genetics* / Q000473:pathology
keywords: COPD; biomarker; endothelial microparticle; exacerbation; exosome; extracellular vesicles; microRNA; microvesicle; pathogenesis; therapy