title: Context- and Tissue-Specific Regulation of Immunity and Tolerance by Regulatory T Cells.
abstract: The immune system has evolved to defend the organism against an almost infinite number of pathogens in a locally confined and antigen-specific manner while at the same time preserving tolerance to harmless antigens and self. Regulatory T (Treg) cells essentially contribute to an immunoregulatory network preventing excessive immune responses and immunopathology. There is emerging evidence that Treg cells not only operate in secondary lymphoid tissue but also regulate immune responses directly at the site of inflammation. Hence, the classification of Treg cells might need to be further extended by Treg cell subsets that are functionally and phenotypically polarized by their residency. In this review, we discuss recent findings on these tissue-resident Treg cell subsets and how these cells may operate in a tissue- and context-dependent manner.
authors: Institute for Immunology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.
authors: A
authors: A
authors: Ulges
authors: Institute for Immunology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.
authors: E
authors: E
authors: Schmitt
authors: University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.
authors: C
authors: C
authors: Becker
authors: Institute for Immunology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany. Electronic address: boppt@uni-mainz.de.
authors: T
authors: T
authors: Bopp
mesh_terms: D000818:Animals; D001324:Autoantigens / Q000276:immunology; D051858:Forkhead Transcription Factors / Q000378:metabolism; D006801:Humans; D007108:Immune Tolerance; D007109:Immunity; D007165:Immunosuppression Therapy; D009928:Organ Specificity; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
chemical_list: D001324:Autoantigens; C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors
keywords: FOXP3; Regulation; Regulatory T cell; Suppression; Thymus; Tissue