title: Successful Management of a Patient with Malignant Thyroid Teratoma.
abstract: Malignant thyroid teratomas are rare tumors with a poor prognosis. Little is known about their pathogenesis or treatment. Here, the case is reported of an adult woman with an aggressive thyroid teratoma with primitive neuroectodermal tumor (PNET) malignant transformation, successfully managed with neoadjuvant chemotherapy and surgery.
  
  
  
  Sequencing of paired tumor and normal tissues revealed a DICER1 c.5438A>G (p.E1813G) somatic mutation in 56% of sequencing reads consistent with a driver event.
  
  
  
  To the authors' knowledge, DICER1 mutations have not been previously reported in teratomas but have been described in PNETs, suggesting a role in the malignant transformation of this case.
authors: 1 Medical Oncology, Dana-Farber Cancer Institute , Boston, Massachusetts.
authors: Guilherme
authors: G
authors: Rabinowits
authors: 2 Department of Anatomic Pathology, Brigham and Women's Hospital , Boston, Massachusetts.
authors: Justine
authors: J
authors: Barletta
authors: 2 Department of Anatomic Pathology, Brigham and Women's Hospital , Boston, Massachusetts.
authors: Lynette M
authors: LM
authors: Sholl
authors: 3 Hospital Marina Salud de Denia , Medical Oncology, Alicante, Spain .
authors: Encarnacion
authors: E
authors: Reche
authors: 1 Medical Oncology, Dana-Farber Cancer Institute , Boston, Massachusetts.
authors: Jochen
authors: J
authors: Lorch
authors: 4 Department of Otolaryngology, Brigham and Women's Hospital , Boston, Massachusetts.
authors: Laura
authors: L
authors: Goguen
mesh_terms: D017024:Chemotherapy, Adjuvant; D005260:Female; D006801:Humans; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D013724:Teratoma / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D013964:Thyroid Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D016896:Treatment Outcome
keywords: PNET; teratoma; thyroid cancer; treatment; tumor sequencing