title: Recalcitrant Verrucae in Patients With DOCK8 Deficiency.
abstract: An 18-year-old Caucasian man presented with extensive recalcitrant verrucae on his trunk and extremities that were unresponsive to cryotherapy, salicylic acid, topical imiquimod, CO2laser, candida antigen, and intralesional bleomycin. He had a diagnosis of hyperimmunoglobulin E syndrome until 2011, when he was determined to have DOCK8 immunodeficiency after genetic testing at the National Institutes of Health. In addition to verrucae, he had a personal history of eczematous dermatitis, osteomyelitis, molluscum infections, cutaneous abscesses, recurrent pneumonia, and severe food allergy.
authors: Divisions of Dermatology; jywanga@gmail.com.
authors: Yen Tun
authors: YT
authors: Wang
authors: Clinical Immunology and Allergy.
authors: Bob
authors: B
authors: Geng
authors: Clinical Immunology and Allergy.
authors: Samantha
authors: S
authors: Gendelman
authors: Ronald Reagan UCLA Medical Center, Los Angeles, CA, and the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.
authors: Alexandra
authors: A
authors: Freeman
authors: Divisions of Dermatology.
authors: Christina Nam-Soo
authors: CN
authors: Kim
mesh_terms: D000293:Adolescent; D017679:Cryotherapy; D020662:Guanine Nucleotide Exchange Factors / Q000172:deficiency*; D006801:Humans; D007589:Job Syndrome / Q000175:diagnosis; D008297:Male; D014860:Warts / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy
chemical_list: C516591:DOCK8 protein, human; D020662:Guanine Nucleotide Exchange Factors