title: Evaluation of Meibomian Gland Dysfunction in Polycystic Ovary Syndrome and Obesity.
abstract: Purpose/Aim of the study: The purpose of this study was to evaluate the interaction between Polycystic ovary syndrome (PCOS) and Meibomian gland dysfunction (MGD) and obesity, to reveal whether there is a correlation between the testosterone levels and body-mass index (BMI) levels and the dry-eye complaints of these patients.
  
  
  
  The study included 92 patients with PCOS and 52 healthy patients from March 2013 to March 2014. All patients underwent a physical examination, pelvic ultrasound, and clinical and biochemical tests, including free testosterone levels to confirm the diagnosis of PCOS. The BMIs of all subjects were recorded. In addition, the presence of posterior blepharitis, as an indicator of MGD, was recorded. All patients underwent the dry-eye tests including Schirmer 1 and tear film break-up time (BUT). Complaints of dry-eye of the patients were evaluated with the ocular surface disease index (OSDI) questionnaire. The scores of both groups were compared.
  
  
  
  The presence of MGD was 72.82% in the PCOS group and 61.53% in the control group. There was no correlation between the testosterone levels and study parameters in both groups. BUT levels negatively correlated with BMI in subjects without PCOS (r = -0.520, p = 0.001), whereas positively correlated with MGD and OSDI scores (r = 0.610, p = 0.632; p = 0.001, p = 0.001; respectively).
  
  
  
  Tear film instability due to MGD is common in PCOS and in subjects with high BMI. The MGD in PCOS patients is independent of the BMI.
authors: a Ozel Egepol Hospital Eye Clinic , Izmir , Turkey.
authors: Gonen
authors: G
authors: Baser
authors: b Department of Gynecology and Obstetrics , Sifa University Izmir , Turkey.
authors: Nurdan
authors: N
authors: Yildiz
authors: c Department of Endocrinology , Bozyaka Education and Investigation Hospital, Izmir , Turkey.
authors: Mehmet
authors: M
authors: Calan
mesh_terms: D000328:Adult; D015992:Body Mass Index; D003941:Diagnostic Techniques, Ophthalmological; D015352:Dry Eye Syndromes / Q000175:diagnosis / Q000209:etiology / Q000378:metabolism; D005141:Eyelid Diseases / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008537:Meibomian Glands / Q000378:metabolism*; D009765:Obesity / Q000097:blood / Q000150:complications* / Q000175:diagnosis; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000150:complications* / Q000175:diagnosis; D011446:Prospective Studies; D012372:ROC Curve; D013666:Tears; D013739:Testosterone / Q000097:blood; D055815:Young Adult
chemical_list: D013739:Testosterone
keywords: Body-mass index; dry-eye syndrome; meibomian gland dysfunction; obesity; polycystic ovary syndrome