title: [A retrospective case-control study of immunoglobulin G4-related disease combined with malignancy].
abstract: IgG4-related disease (IgG4-RD) has been proved to be associated with malignancy.The incidence and risk factors of malignancy development in IgG4-RD were not clear. Nine IgG4-RD patients with malignancies and 27 IgG4-RD control cases were analyzed for risk factors and clinical features. The incidence of malignancy in IgG4-RD was 3.3%, higher than age-controlled general population. Smoking history was significantly more common in patients with malignancies than in the control group (9/9 vs 16/27,P<0.05). A total of 6/9 malignancies occurred within the first year after the diagnosis of IgG4-RD. Colorectal, biliary and thyroid cancers were the leading types. Smoking history is a risk factor for IgG4-RD associated malignancy. Careful vigilance to monitor malignancy needs to be paid during follow-up.
authors: Department of Gastroenterology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
authors: Y L
authors: YL
authors: Feng
authors: D
authors: D
authors: Wu
authors: S Y
authors: SY
authors: Zhang
authors: X
authors: X
authors: Wu
authors: H J
authors: HJ
authors: Shu
authors: A M
authors: AM
authors: Yang
authors: J M
authors: JM
authors: Qian
mesh_terms: D001327:Autoimmune Diseases / Q000150:complications* / Q000175:diagnosis* / Q000453:epidemiology; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000096:biosynthesis*; D015994:Incidence; D008297:Male; D009369:Neoplasms / Q000175:diagnosis / Q000453:epidemiology* / Q000473:pathology; D012189:Retrospective Studies
chemical_list: D007074:Immunoglobulin G