title: [Value of non-invasive models of liver fibrosis in judgment of treatment timing in chronic hepatitis B patients with ALT < 2×upper limit of normal].
abstract: Objective:To investigate the value of non-invasive liver fibrosis models, FIB-4, S index, aspartate aminotransferase to platelet ratio index(APRI), globulin-platelet(GP)model, aspartate aminotransferase/platelet/gamma-glutamyl transpeptidase/alpha-fetoprotein(APGA), and platelet/age/phosphatase/alpha-fetoprotein/aspartate aminotransferase(PAPAS), in the diagnosis of marked liver fibrosis in chronic hepatitis B(CHB)patients with ALT < 2×upper limit of normal(ULN), as well as treatment timing for this population.Methods:A total of 389 CHB patients with ALT < 2×ULN who were admitted to Beijing Ditan Hospital and whose treatment timing was difficult to judge were enrolled. Transdermal liver biopsy was performed to obtain pathological results, and routine serological tests were performed, including routine blood test, serum biochemical parameters, hepatitis B virus(HBV)markers, and HBV DNA. According to liver pathology, the patients were divided into non-marked liver fibrosis group(S < 2)with 324 patients and marked liver fibrosis group(S≥2)with 65 patients. The non-invasive models for predicting liver fibrosis was established with reference to original articles. SPSS 19.0 software was used for statistical analysis, and the receiver operating characteristic(ROC)curve was used to compare the value of different non-invasive models in predicting marked liver fibrosis in this population.Results:All the non-invasive models had a certain diagnostic value for liver fibrosis degree in these patients, and the areas under the ROC curve for APRI, FIB-4, APGA, S index, PAPAS, and GP model were 0.718, 0.691, 0.758, 0.729, 0.673, and 0.691, respectively. APGA had the largest area under the ROC curve(0.758, 95%CI0.673-0.844), and gamma-glutamyl transpeptidase was significantly positively correlated with liver fibrosis degree.Conclusion:The non-invasive models of liver fibrosis can identify marked liver fibrosis in CHB patients with ALT < 2×ULN in whom it is difficult to judge treatment timing and help to determine treatment timing for them. APGA model has the highest value and can reduce the need for liver biopsy to the certain degree.
authors: Department of Infectious Diseases, Ruian People's Hospital, Wenzhou 325200, China.
authors: Q Q
authors: QQ
authors: Zhou
authors: Wenzhou Medical University, Wenzhou 325035, China.
authors: Y B
authors: YB
authors: Hu
authors: Department of Infectious Diseases, Ruian People's Hospital, Wenzhou 325200, China.
authors: K
authors: K
authors: Zhou
authors: Department of Infectious Diseases, Ruian People's Hospital, Wenzhou 325200, China.
authors: W W
authors: WW
authors: Zhang
authors: Liver Center of Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
authors: M H
authors: MH
authors: Li
authors: Department of Infectious Diseases, Ruian People's Hospital, Wenzhou 325200, China.
authors: P
authors: P
authors: Dong
authors: Department of Infectious Diseases, Ruian People's Hospital, Wenzhou 325200, China.
authors: J G
authors: JG
authors: Di
authors: Department of Infectious Diseases, Ruian People's Hospital, Wenzhou 325200, China.
authors: L
authors: L
authors: Hong
authors: Department of Infectious Diseases, Ruian People's Hospital, Wenzhou 325200, China.
authors: Q W
authors: QW
authors: Du
authors: Liver Center of Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
authors: Y
authors: Y
authors: Xie
authors: Department of Infectious Diseases, Ruian People's Hospital, Wenzhou 325200, China.
authors: Q F
authors: QF
authors: Sun
mesh_terms: D000328:Adult; D001219:Aspartate Aminotransferases / Q000097:blood; D015415:Biomarkers / Q000097:blood; D001706:Biopsy; D001792:Blood Platelets; D005260:Female; D006515:Hepatitis B virus; D019694:Hepatitis B, Chronic / Q000097:blood / Q000150:complications* / Q000175:diagnosis*; D006801:Humans; D007600:Judgment; D008103:Liver Cirrhosis / Q000097:blood / Q000150:complications* / Q000175:diagnosis*; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D011237:Predictive Value of Tests; D012372:ROC Curve; D015203:Reproducibility of Results; D012189:Retrospective Studies; D000509:alpha-Fetoproteins / Q000378:metabolism; D005723:gamma-Glutamyltransferase / Q000097:blood
chemical_list: D015415:Biomarkers; D000509:alpha-Fetoproteins; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases