title: The Gas6/TAM System and Multiple Sclerosis.
abstract: Growth arrest specific 6 (Gas6) is a multimodular circulating protein, the biological actions of which are mediated by the interaction with three transmembrane tyrosine kinase receptors: Tyro3, Axl, and MerTK, collectively named TAM. Over the last few decades, many progresses have been done in the understanding of the biological activities of this highly pleiotropic system, which plays a role in the regulation of immune response, inflammation, coagulation, cell growth, and clearance of apoptotic bodies. Recent findings have further related Gas6 and TAM receptors to neuroinflammation in general and, specifically, to multiple sclerosis (MS). In this paper, we review the biology of the Gas6/TAM system and the current evidence supporting its potential role in the pathogenesis of MS.
authors: Department of Translational Medicine, Università del Piemonte Orientale, UPO, via Solaroli 17, 28100 Novara, Italy. bellanmattia@yahoo.it.|Immuno-rheumatology Unit, Internal Medicine Division, "Maggiore della Carità" Hospital, 28100 Novara, Italy. bellanmattia@yahoo.it.|IRCAD, Interdisciplinary Research Center of Autoimmune Diseases, 28100 Novara, Italy. bellanmattia@yahoo.it.
authors: Mattia
authors: M
authors: Bellan
authors: Department of Translational Medicine, Università del Piemonte Orientale, UPO, via Solaroli 17, 28100 Novara, Italy. mario.pirisi@med.uniupo.it.|Immuno-rheumatology Unit, Internal Medicine Division, "Maggiore della Carità" Hospital, 28100 Novara, Italy. mario.pirisi@med.uniupo.it.|IRCAD, Interdisciplinary Research Center of Autoimmune Diseases, 28100 Novara, Italy. mario.pirisi@med.uniupo.it.
authors: Mario
authors: M
authors: Pirisi
authors: Immuno-rheumatology Unit, Internal Medicine Division, "Maggiore della Carità" Hospital, 28100 Novara, Italy. pierpaolo.sainaghi@med.uniupo.it.|IRCAD, Interdisciplinary Research Center of Autoimmune Diseases, 28100 Novara, Italy. pierpaolo.sainaghi@med.uniupo.it.
authors: Pier Paolo
authors: PP
authors: Sainaghi
mesh_terms: D000818:Animals; D006801:Humans; D007249:Inflammation / Q000235:genetics / Q000473:pathology; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics*; D009103:Multiple Sclerosis / Q000235:genetics* / Q000473:pathology; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics*; D015398:Signal Transduction; D000076202:c-Mer Tyrosine Kinase; D000094963:Axl Receptor Tyrosine Kinase; D000099255:Growth Arrest-Specific Protein 6
chemical_list: D036341:Intercellular Signaling Peptides and Proteins; D011518:Proto-Oncogene Proteins; D020794:Receptor Protein-Tyrosine Kinases; D000076202:c-Mer Tyrosine Kinase; D000094963:Axl Receptor Tyrosine Kinase; D000099255:Growth Arrest-Specific Protein 6; C097072:MERTK protein, human; C084944:TYRO3 protein, human; C000722289:AXL protein, human
keywords: Axl; Gas6; MerTK; TAM receptors; Tyro3; multiple sclerosis