title: Lectin adhesion proteins (P-, L- and E-selectins) as biomarkers in colorectal cancer.
abstract: BACKGROUND
  Selectins probably participate in the interactions between platelets and other inflammatory cells in cancer invasion and metastasis formation. We assessed a potential relationship of P-, L- and E-selectin in colorectal cancer (CRC) patients in relation to tumour advancement according to TNM classification, and tumour location.
  
  
  METHODS
  The study group was composed of 53 CRC patients and 25 healthy subjects. Plasma levels of soluble P-, L- and E-selectins were measured using the immunoenzymatic method with Quantikine kits (R&D Systems, Minneapolis, MN).
  
  
  RESULTS
  The mean levels of all selectins were significantly higher in CRC patients compared to healthy controls. The highest level of sP-selectin was observed in patients with metastases to the liver (stage IV), and was significantly higher than in patients without metastases (stage I/II) and with lymph node metastases (stage III), p = .02. The highest levels of sL- and sE-selectin were observed in patients with lymph node metastasis. We also found sP-selectin to be the best predictor of CRC.
  
  
  CONCLUSIONS
  Our finding show possible involvement of tested selectins in CRC advancement and forming metastasis. Among sL- and E- selectins, P-selectin plays an important role in the progression of CRC and could be an attractive biomarker with clinical significance.
authors: a Department of Clinical Laboratory Diagnostics , Medical University of Bialystok , Poland.
authors: Aleksandra
authors: A
authors: Korniluk
authors: a Department of Clinical Laboratory Diagnostics , Medical University of Bialystok , Poland.
authors: Joanna
authors: J
authors: Kamińska
authors: a Department of Clinical Laboratory Diagnostics , Medical University of Bialystok , Poland.
authors: Paweł
authors: P
authors: Kiszło
authors: a Department of Clinical Laboratory Diagnostics , Medical University of Bialystok , Poland.
authors: Halina
authors: H
authors: Kemona
authors: a Department of Clinical Laboratory Diagnostics , Medical University of Bialystok , Poland.
authors: Violetta
authors: V
authors: Dymicka-Piekarska
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood*; D016022:Case-Control Studies; D015815:Cell Adhesion Molecules / Q000097:blood*; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000473:pathology*; D019040:E-Selectin; D005260:Female; D006801:Humans; D019041:L-Selectin; D008113:Liver Neoplasms / Q000556:secondary; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis / Q000175:diagnosis; D019007:P-Selectin / Q000097:blood*
chemical_list: D014408:Biomarkers, Tumor; D015815:Cell Adhesion Molecules; D019040:E-Selectin; D019007:P-Selectin; C546936:SELE protein, human; C546935:SELL protein, human; C546937:SELP protein, human; D019041:L-Selectin
keywords: Colorectal cancer; biomarker; metastasis; sE-selectin; sL-selectin; sP-selectin