title: Diallyl Sulfide and Its Role in Chronic Diseases Prevention.
abstract: Diallyl sulfide (C6H10S, DAS) is one of the novel natural organosulfur compounds, which is mostly obtained from the genus Allium plants. Numerous studies have revealed several unique properties of DAS in terms of its health-promoting effects. DAS has proved to be anticancer, antimicrobial, anti-angiogenic, and immunomodulatory like unique functions as demonstrated by the multiple investigations. Diallyl sulfide can also impede oxidative stress and chronic inflammation as suggested by the literature. Studies also explored that DAS could thwart the development of chronic diseases like cancer, neuronal, cardiovascular disease through modulating mechanistic pathways involved in pathogenesis. In this book chapter, we have attempted to give the comprehensive view on DAS about the physiochemical and biological properties, and its preventive role in chronic diseases with a mechanistic overview.
authors: Food, Drug and Chemical Toxicology Division, CSIR-Indian Institute of Toxicology Research, 31, Vish Vigyan Bhawan, M.G. Marg, Lucknow, 226001, Uttar Pradesh, India.
authors: Shankar
authors: S
authors: Suman
authors: Food, Drug and Chemical Toxicology Division, CSIR-Indian Institute of Toxicology Research, 31, Vish Vigyan Bhawan, M.G. Marg, Lucknow, 226001, Uttar Pradesh, India. yshukla@iitr.res.in.
authors: Yogeshwer
authors: Y
authors: Shukla
mesh_terms: D000490:Allium / Q000737:chemistry*; D000498:Allyl Compounds / Q000302:isolation & purification / Q000627:therapeutic use*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000302:isolation & purification / Q000627:therapeutic use*; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000627:therapeutic use*; D000975:Antioxidants / Q000302:isolation & purification / Q000627:therapeutic use*; D002908:Chronic Disease / Q000517:prevention & control*; D055808:Drug Discovery / Q000379:methods*; D006801:Humans; D008517:Phytotherapy; D010946:Plants, Medicinal; D015398:Signal Transduction / Q000187:drug effects; D013440:Sulfides / Q000302:isolation & purification / Q000627:therapeutic use*
chemical_list: D000498:Allyl Compounds; D000893:Anti-Inflammatory Agents; D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants; D013440:Sulfides; C038491:allyl sulfide
keywords: Biological activities; Chronic disease; Diallyl sulfide; Signaling pathways