title: Ten years of PCV2 vaccines and vaccination: Is eradication a possibility?
abstract: More than two decades after its emergence, porcine circovirus type 2 (PCV2) remains an economically important swine pathogen. Commercial vaccines which were first introduced to the U.S in 2006, have been highly effective in reducing clinical signs and improving production. Recent studies have indicated a declining level of PCV2 prevalence and viremia in the field. However, reports on the emergence of new viral variants have also continued to increase. This article reviews topics of current interest in the field of PCV2 vaccines; including the comparative efficacy of the available commercial products, efficacy of current vaccines against new and emerging strains, findings on the differences between immunity in natural infection versus vaccination, limitations of current experimental models for PCV2 vaccine studies, and new developments in novel experimental vaccines. The discussion is framed in the context of attempts for the possible eradication of PCV2 in the future.
authors: Department of Microbiological Sciences, North Dakota State University, Fargo, ND, United States.
authors: Zahra
authors: Z
authors: Afghah
authors: Veterinary Diagnostic Laboratory, North Dakota State University, Fargo, ND, United States.
authors: Brett
authors: B
authors: Webb
authors: Department of Biomedical Sciences and Pathobiology, College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA, United States.
authors: Xiang-Jin
authors: XJ
authors: Meng
authors: Department of Microbiological Sciences, North Dakota State University, Fargo, ND, United States. Electronic address: Sheela.ramamoorthy@ndsu.edu.
authors: Sheela
authors: S
authors: Ramamoorthy
mesh_terms: D000818:Animals; D018173:Circoviridae Infections / Q000453:epidemiology / Q000517:prevention & control / Q000662:veterinary* / Q000821:virology; D017925:Circovirus / Q000276:immunology*; D013552:Swine; D013553:Swine Diseases / Q000453:epidemiology / Q000517:prevention & control* / Q000821:virology; D014611:Vaccination / Q000662:veterinary*; D014766:Viremia / Q000662:veterinary
keywords: Eradication; Porcine circovirus 2 associated diseases (PCVAD); Porcine circovirus type 2 (PCV2); Post weaning multi-systemic wasting syndrome (PMWS); Vaccine