title: Unnatural Amino Acid Synthesis Enabled by the Regioselective Cobalt(III)-Catalyzed Intermolecular Carboamination of Alkenes.
abstract: Herein, we report an unprecedented regioselective and entirely atom-economic cobalt(III)-catalyzed method for the non-annulative, intermolecular carboamination of alkenes. The methodology enables the direct synthesis of unnatural amino acid derivatives and proceeds under redox-neutral conditions with a completely regioselective C-C bond and C-N bond formation. Furthermore, this reaction exemplifies the inherently different mechanistic behavior of the Cp*CoIIIcatalyst and its Cp*RhIIIcounterpart, especially towards β-H-elimination.
authors: Westfälische Wilhelms-Universität Münster, Organisch-Chemisches Institut, Corrensstrasse 40, 48149, Münster, Germany.
authors: Andreas
authors: A
authors: Lerchen
authors: Westfälische Wilhelms-Universität Münster, Organisch-Chemisches Institut, Corrensstrasse 40, 48149, Münster, Germany.
authors: Tobias
authors: T
authors: Knecht
authors: Westfälische Wilhelms-Universität Münster, Organisch-Chemisches Institut, Corrensstrasse 40, 48149, Münster, Germany.
authors: Constantin G
authors: CG
authors: Daniliuc
authors: Westfälische Wilhelms-Universität Münster, Organisch-Chemisches Institut, Corrensstrasse 40, 48149, Münster, Germany.
authors: Frank
authors: 0000-0002-0648-956X
authors: F
authors: Glorius
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D000586:Amination; D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003035:Cobalt / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000475:Alkenes; D000596:Amino Acids; D003035:Cobalt
keywords: Cp*Co(III) catalysis; alkene difunctionalization; carboamination; redox-neutral conditions; unnatural amino acids