title: The Effect of Chinese Herbal Medicine Gualouxiebaibanxia Decoction for the Treatment of Angina Pectoris: A Systematic Review.
abstract: We systematically assess the current clinical evidence of Gualouxiebaibanxia (GLXBBX) decoction for the treatment of angina pectoris (AP). We included RCTs testing GLXBBX against conventional drugs and GLXBBX combined with conventional drugs versus conventional drugs. 19 RCTs involving 1730 patients were finally identified, and the methodological quality was evaluated as generally low. The results of the meta-analysis showed that GLXBBX alone had significant effect on improving angina symptoms (RR: 1.24, 95% CI 1.14 to 1.35;P< 0.00001), ECG (RR: 1.28 [1.13,1.44];P< 0.0001), and HDL-C (MD: 0.56 [0.54,0.58];P< 0.00001) compared with anti-arrhythmic drugs. A significant improvement in angina symptoms (RR: 1.17 [1.12,1.22];P< 0.00001) and ECG (RR = 1.22; 95% CI = [1.14,1.30];P< 0.00001) was observed for GLXBBX plus conventional drugs when compared with conventional drugs. Eight trials reported adverse events without serious adverse effects. GLXBBX appears to have beneficial effects on improvement of ECG and reduction of angina symptoms in participants with AP. However, the evidence remains weak due to the poor methodological quality of the included studies. More rigorous trials are needed to confirm the results.
authors: Department of Cardiology, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China.
authors: Wei
authors: 0000-0002-4009-9493
authors: W
authors: Liu
authors: Department of Cardiology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China.
authors: Xingjiang
authors: 0000-0002-6874-8344
authors: X
authors: Xiong
authors: Department of Cardiology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China.
authors: Xiaochen
authors: 0000-0001-6306-7665
authors: X
authors: Yang
authors: Department of Cardiology, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China.
authors: Fuyong
authors: 0000-0003-3213-265X
authors: F
authors: Chu
authors: Department of Cardiology, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China.
authors: Hongxu
authors: 0000-0002-4198-7417
authors: H
authors: Liu