title: Gastric-type H+,K+-ATPase in mouse vestibular end organs.
abstract: CONCLUSIONS
  Gastric type H+,K+-ATPase in the vestibular end organs may be of importance for K+circulation and may also be related to pH regulation in vestibular end organs and endolymphatic sac.
  
  
  OBJECTIVE
  To analyze the expression of gastric-type H+,K+-ATPase in normal mouse vestibular end organs.
  
  
  METHODS
  8 weeks old CBA/J mice were used in this study. The presence of gastric-type H+,K+-ATPase α and β in the vestibular end organs, viz. utricle, saccule, ampulla, vestibular ganglion, and endolymphatic sac, was investigated using immunohistochemistry.
  
  
  RESULTS
  In the vestibular end organs, H+,K+-ATPase α and β were almost identical. H+,K+-ATPase was expressed in sensory cells, the basolateral surface of dark cells, fibrocytes, in vestibular ganglion cells, and in the upper region of the endolymphatic sac epithelial cells.
authors: a Department of Otolaryngology , University Hospital , Hiroshima , Japan.
authors: Masaya
authors: M
authors: Takumida
authors: b University of Tokyo Hospital , Tokyo , Japan.
authors: Hiroshi
authors: H
authors: Takumida
authors: c Department of Otolaryngolog and Head & Neck Surgery , Uppsala University , Uppsala , Sweden.
authors: Matti
authors: M
authors: Anniko
mesh_terms: D000818:Animals; D017506:H(+)-K(+)-Exchanging ATPase / Q000302:isolation & purification* / Q000378:metabolism; D008575:Meniere Disease / Q000188:drug therapy; D008808:Mice, Inbred CBA; D054328:Proton Pump Inhibitors / Q000627:therapeutic use; D014722:Vestibule, Labyrinth / Q000201:enzymology*
chemical_list: D054328:Proton Pump Inhibitors; D017506:H(+)-K(+)-Exchanging ATPase
keywords: Hydrogen, potassium-adenosine triphosphatase; immunohistochemistry; vestibular end organ