title: Antioxidant and wound healing activity of Lavandula aspic L. ointment.
abstract: Lavandula aspic L. is a strongly aromatic shrub plant of the Lamiaceae family and traditionally used in herbal medicine for the treatment of several skin disorders, including wounds, burns, and ulcers. The present study aimed to investigate the composition and in vitro antioxidant activity of lavender essential oil. In addition, it aimed to evaluate the excision wound healing activity and antioxidant property of a Lavandula aspic L. essential oil formulated in ointment using a rat model. The rats were divided into five groups of six animals each. The test groups were topically treated with the vehicle, lavender ointment (4%) and a reference drug, while the control group was left untreated. Wound healing efficiency was determined by monitoring morphological and biochemical parameters and skin histological analysis. Wound contraction and protein synthesis were also determined. Antioxidant activity was assessed by the determination of MDA rates and antioxidant enzymes (GPx, catalase and superoxide dismutase). The treatment with lavender ointment was noted to significantly enhance wound contraction rate (98%) and protein synthesis. Overall, the results provided strong support for the effective wound healing activity of lavender ointment, making it a promising candidate for future application as a therapeutic agent in tissue repairing processes associated with skin injuries.
authors: Coastal and Urban Environments, National Engineering School of Sfax, Sfax University, B.P. 1173, 3038 Sfax, Tunisia; Animal Physiology Laboratory, Faculty of Sciences in Sfax, Sfax University, B.P. 95, 3000 Sfax, Tunisia. Electronic address: ghrab.ferdaws@yahoo.fr.
authors: Ferdaous Ghrab
authors: FG
authors: Ben Djemaa
authors: Animal Physiology Laboratory, Faculty of Sciences in Sfax, Sfax University, B.P. 95, 3000 Sfax, Tunisia. Electronic address: khaledbra3@gmail.com.
authors: Khaled
authors: K
authors: Bellassoued
authors: Animal Physiology Laboratory, Faculty of Sciences in Sfax, Sfax University, B.P. 95, 3000 Sfax, Tunisia. Electronic address: samiaz2004@yahoo.fr.
authors: Sami
authors: S
authors: Zouari
authors: Animal Physiology Laboratory, Faculty of Sciences in Sfax, Sfax University, B.P. 95, 3000 Sfax, Tunisia. Electronic address: abdelfattah.elfeki@fss.rnu.tn.
authors: Abdelfatteh
authors: A
authors: El Feki
authors: Coastal and Urban Environments, National Engineering School of Sfax, Sfax University, B.P. 1173, 3038 Sfax, Tunisia. Electronic address: ammarenis@yahoo.fr.
authors: Emna
authors: E
authors: Ammar
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000627:therapeutic use; D005260:Female; D006097:Granulation Tissue / Q000187:drug effects; D027523:Lavandula / Q000737:chemistry; D015227:Lipid Peroxidation / Q000187:drug effects; D009822:Oils, Volatile / Q000737:chemistry / Q000627:therapeutic use; D010938:Plant Oils / Q000737:chemistry / Q000627:therapeutic use; D011920:Rats, Inbred WF; D012867:Skin / Q000033:anatomy & histology / Q000187:drug effects* / Q000293:injuries; D013997:Time Factors; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D000975:Antioxidants; D009822:Oils, Volatile; D010938:Plant Oils; C045718:lavender oil
keywords: Biochemical parameters; Excision wound; Healing activity; Histology; Lavandula aspic L.