title: Hospital-based Surveillance for Rotavirus Gastroenteritis Among Young Children in Bangladesh: Defining the Potential Impact of a Rotavirus Vaccine Program.
abstract: In anticipation of introduction of a rotavirus vaccine into the national immunization program of Bangladesh, active hospital-based surveillance was initiated to provide prevaccine baseline data on rotavirus disease.
  
  
  
  Children 5 years of age and younger admitted with acute gastroenteritis (AGE) (≥3 watery or looser-than-normal stools or ≥1 episode of forceful vomiting) at 7 hospitals throughout Bangladesh were identified. Clinical information and stool specimens were collected from every 4th patient. Specimens were tested for rotavirus antigen by enzyme immunoassays; 25% of detected rotaviruses were genotyped.
  
  
  
  From July 2012 to June 2015, rotavirus was detected in 2432 (64%) of 3783 children hospitalized for AGE. Eight enrolled children died, including 4 (50%) who were rotavirus positive. Rotavirus was detected year-round in Bangladesh with peak detection rates of >80% during November-February. Most (86%) rotavirus AGE cases were 6-23 months of age. Sixty-nine percent of children with rotavirus had severe disease (Vesikari score, ≥11). Among 543 strains genotyped, G1P[8] (31%) and G12P[8] (29%) were the most common.
  
  
  
  Rotavirus is a major cause of morbidity in Bangladeshi children, accounting for nearly two-thirds of AGE hospitalizations. These data highlight the potential value of rotavirus vaccination in Bangladesh, and will be the key for future measurement of vaccine impact.
authors: From the *Programme for Emerging Infections, Infectious Diseases Division, International Centre for Diarrheal Disease Research (icddr,b), Dhaka, Bangladesh; †Division of Viral Diseases, Centers for Disease Control and Prevention(CDC), Atlanta, Georgia; ‡Department of Epidemiology, Institute of Epidemiology, Disease Control and Research (IEDCR), Dhaka, Bangladesh; §Center for Innovation in Global Health, Stanford University, Stanford, California; and ¶Western Pacific Regional Office, WHO, Manila, Philippines; Centers for Disease Control and Prevention(CDC), Atlanta, Georgia.
authors: Syed M
authors: SM
authors: Satter
authors: Paul A
authors: PA
authors: Gastanaduy
authors: Khaleda
authors: K
authors: Islam
authors: Mahmudur
authors: M
authors: Rahman
authors: Mustafizur
authors: M
authors: Rahman
authors: Stephen P
authors: SP
authors: Luby
authors: James D
authors: JD
authors: Heffelfinger
authors: Umesh D
authors: UD
authors: Parashar
authors: Emily S
authors: ES
authors: Gurley
mesh_terms: D001459:Bangladesh / Q000453:epidemiology; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D005759:Gastroenteritis / Q000453:epidemiology* / Q000517:prevention & control / Q000821:virology; D006760:Hospitalization / Q000706:statistics & numerical data*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D062486:Public Health Surveillance; D012401:Rotavirus; D012400:Rotavirus Infections / Q000453:epidemiology* / Q000517:prevention & control / Q000821:virology; D022243:Rotavirus Vaccines; D014611:Vaccination / Q000706:statistics & numerical data
chemical_list: D022243:Rotavirus Vaccines