title: Kidney Transplantation From Brain-Dead Donors: Initial Experience in China.
abstract: BACKGROUND
  Experience with kidney transplantation from brain-dead donors remains limited in China. Our objective was to evaluate the outcomes of kidney transplantation from brain-dead donors (group 1), compared with those from living ones of the same age (group 2).
  
  
  METHODS
  Clinical data of kidney transplantation from brain-dead donors and living donors in the same age range (18-45 years) performed between May 2007 and December 2011 were analyzed retrospectively. Recipients were analyzed for posttransplantation serum creatinine, creatinine clearance (calculated by the Cockcroft-Gault formula), the number of acute rejection episodes and delayed graft function, and patient/graft survival.
  
  
  RESULTS
  Mean donor age was comparable between the 2 groups (31.9 ± 6.5 vs 32.8 ± 7.0 years; P = .268). The terminal serum creatinine level of donors was 125.5 ± 63.5 μmol/L in group 1 (n = 30) and 65.1 ± 13.7 μmol/L in group 2 (n = 110; P = .000). Recipient creatinine clearance was comparable between the 2 groups 1 month posttransplantation and thereafter. Acute rejection episodes were seen in 7 cases in recipients of group 1 (15.9%) and in 15 cases in recipients of group 2 (13.6%; P = .716). The incidence of delayed graft function was higher in recipients of group 1 (18.2%) than that of group 2 (3.6%; P = .002). The 1-, 3-, and 5-year patient/graft survival rate was comparable between the 2 groups.
  
  
  CONCLUSIONS
  Our study demonstrated kidney transplantation from brain-dead donors achieved acceptable graft function and patient/graft survival in the 5-year follow-up, encouraging the use of this approach.
authors: Department of Organ Transplantation, First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.
authors: Y
authors: Y
authors: Li
authors: Department of Organ Transplantation, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
authors: J
authors: J
authors: Li
authors: Department of Organ Transplantation, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
authors: Q
authors: Q
authors: Fu
authors: Department of Organ Transplantation, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
authors: L
authors: L
authors: Chen
authors: Department of Organ Transplantation, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
authors: J
authors: J
authors: Fei
authors: Department of Organ Transplantation, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
authors: S
authors: S
authors: Deng
authors: Department of Organ Transplantation, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
authors: J
authors: J
authors: Qiu
authors: Department of Organ Transplantation, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
authors: G
authors: G
authors: Chen
authors: Department of Organ Transplantation, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
authors: G
authors: G
authors: Huang
authors: Department of Organ Transplantation, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China. Electronic address: wcx6363@163.com.
authors: C
authors: C
authors: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D001926:Brain Death; D002681:China; D003404:Creatinine / Q000097:blood; D051799:Delayed Graft Function / Q000453:epidemiology* / Q000209:etiology; D046148:Donor Selection / Q000379:methods*; D005260:Female; D006084:Graft Rejection / Q000453:epidemiology* / Q000209:etiology; D006085:Graft Survival; D006801:Humans; D015994:Incidence; D016030:Kidney Transplantation / Q000379:methods / Q000401:mortality*; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D003404:Creatinine