title: Prognostic significance of insulin-like growth factor-I serum levels in acute decompensation of cirrhosis.
abstract: BACKGROUND
  IGF-I serum levels are suppressed in cirrhosis, but its prognostic significance is unknown.
  
  
  OBJECTIVE
  To investigate the prognostic value of IGF-I in patients admitted for acute decompensation of cirrhosis.
  
  
  METHODS
  Cohort study that included 103 patients. IGF-I was measured by enzyme-linked immunosorbent assay (ELISA).
  
  
  RESULTS
  Ninety-day mortality was 26.2% and it was independently associated with MELD, age and IGF-I. The Kaplan-Meier survival probability at 90 days was 94.3% in patients with IGF-I ≥13 ng/mL and 63.2% for patients with IGF-I <13 ng/mL (p = .001).
  
  
  CONCLUSIONS
  IGF-I levels are independently associated with mortality in acute decompensation of cirrhosis.
authors: a Division of Gastroenterology , Federal University of Santa Catarina , Florianópolis , Brazil.
authors: Bruno da Silveira
authors: BD
authors: Colombo
authors: a Division of Gastroenterology , Federal University of Santa Catarina , Florianópolis , Brazil.
authors: Marcelo Fernando
authors: MF
authors: Ronsoni
authors: a Division of Gastroenterology , Federal University of Santa Catarina , Florianópolis , Brazil.
authors: Pedro Eduardo
authors: PE
authors: Soares E Silva
authors: a Division of Gastroenterology , Federal University of Santa Catarina , Florianópolis , Brazil.
authors: Leonardo
authors: L
authors: Fayad
authors: b Department of Clinical Analysis , Federal University of Santa Catarina , Florianópolis , Brazil.
authors: Letícia Muraro
authors: LM
authors: Wildner
authors: b Department of Clinical Analysis , Federal University of Santa Catarina , Florianópolis , Brazil.
authors: Maria Luiza
authors: ML
authors: Bazzo
authors: a Division of Gastroenterology , Federal University of Santa Catarina , Florianópolis , Brazil.
authors: Esther Buzaglo
authors: EB
authors: Dantas-Correa
authors: a Division of Gastroenterology , Federal University of Santa Catarina , Florianópolis , Brazil.
authors: Janaína Luz
authors: JL
authors: Narciso-Schiavon
authors: a Division of Gastroenterology , Federal University of Santa Catarina , Florianópolis , Brazil.
authors: Leonardo Lucca
authors: LL
authors: Schiavon
mesh_terms: D000368:Aged; D015331:Cohort Studies; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D006975:Hypertension, Portal; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D053208:Kaplan-Meier Estimate; D008103:Liver Cirrhosis / Q000097:blood / Q000401:mortality*; D008875:Middle Aged; D011379:Prognosis; D016019:Survival Analysis
chemical_list: D007334:Insulin-Like Growth Factor I
keywords: IGF-I; Liver cirrhosis; ascites; portal hypertension