title: Leptin Regulates Tau Phosphorylation through Wnt Signaling Pathway in PC12 Cells.
abstract: OBJECTIVE
  Leptin, an adipocytokine produced endogenously in the brain, is decreased in Alzheimer's disease(AD) and has also been shown to reduce Aβ levels in vitro and in vivo. Sets of evidence show that leptin reduces Aβ production and tau phosphorylation in neuronal cells and transgenic mice models of AD. Herein, we investigated the signaling pathway activated by leptin, to better understand its mechanism of action.
  
  
  METHODS
  Western blotting was performed to assess the levels of phosphor-tau and Bax, RT-PCR to check the mRNA level of Bax.
  
  
  RESULTS
  Leptin treatment significantly blunted Aβ-evoked tau phosphorylation and Bax levels, effects of which could be reversed by antagonist of Wnt signaling.
  
  
  CONCLUSIONS
  The data indicate that Leptin may provide a novel therapeutic approach to AD treatment via wnt signaling.
authors: Experimental teaching center, Basic Medical College of Henan University of Chinese Medicine, Zhengzhou, China.
authors: Zijuan
authors: Z
authors: Zhang
authors: Meixia
authors: M
authors: Guo
authors: Juan
authors: J
authors: Zhang
authors: Caixia
authors: C
authors: Du
authors: Ying
authors: Y
authors: Xing
keywords: Alzheimer’s disease; Leptin; PC12 cells; Tau; Wnt