title: Abnormal serotonin transporter availability in the brains of adults with conduct disorder.
abstract: OBJECTIVE
  The aims of the current study were to determine whether patients with conduct disorder (CD) showed an abnormal availability of serotonin reuptake transporter (SERT), and if their hyperkinetic symptoms, impulsivity, and quality of life were correlated with the availability of SERT.
  
  
  METHODS
  We recruited 14 drug-naïve patients with CD and eight age-matched healthy controls (HCs). The adult attention-deficit/hyperactivity disorder (ADHD) self-report scale (ASRS), Barrett impulsivity scale (BIS), and the World Health Organization quality of life-brief version (WHOQOL-BREF) scale were administered. Positron emission tomography (PET) of the brain with 4-[18F]-ADAM was arranged for SERT imaging.
  
  
  RESULTS
  SERT availability was significantly reduced in the striatum and midbrain of patients with CD. Quality of life and inattention symptoms were also significantly correlated with the availability of SERT in the prefrontal cortex.
  
  
  CONCLUSIONS
  The study suggested that a reduction in the availability of SERT might be associated with CD and could potentially predict poor quality of life or symptoms of inattention for these patients. The implications of our results might be limited to individuals with CD; a future study with a larger sample to validate our preliminary results is warranted.
authors: Department of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
authors: Chieh
authors: C
authors: Chang
authors: Department of Psychiatry, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan.
authors: Susan Shur-Fen
authors: SS
authors: Gau
authors: Department of Nuclear Medicine, Taipei Veterans General Hospital, National Yang-Ming University, Taipei, Taiwan; Department of Nuclear Medicine, Tri-Service General Hospital, National Defense Medical Center, and Department of Nuclear Medicine, National Taiwan University Hospital, Taipei, Taiwan; Department of Nuclear Medicine, Changhua Christian Hospital, Changhua, Taiwan.
authors: Wen-Sheng
authors: WS
authors: Huang
authors: Department of Nuclear Medicine, Tri-Service General Hospital, National Defense Medical Center, and Department of Nuclear Medicine, National Taiwan University Hospital, Taipei, Taiwan.
authors: Chyng-Yann
authors: CY
authors: Shiue
authors: Department of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan; Department of Psychology, SooChow University, Taipei, Taiwan. Electronic address: chinbinyeh@gmail.com.
authors: Chin-Bin
authors: CB
authors: Yeh
mesh_terms: D000328:Adult; D001289:Attention Deficit Disorder with Hyperactivity / Q000378:metabolism; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism*; D016022:Case-Control Studies; D019955:Conduct Disorder / Q000378:metabolism*; D006801:Humans; D008297:Male; D049268:Positron-Emission Tomography; D011788:Quality of Life; D050486:Serotonin Plasma Membrane Transport Proteins / Q000378:metabolism*
chemical_list: C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins
keywords: conduct disorder; positron emission tomography; serotonin transporter