title: Decline in ventricular function as a result of general anesthesia in pediatric heart transplant recipients.
abstract: Echocardiography is frequently performed under anesthesia during procedures such as cardiac catheterization with EMB in pediatric HTx recipients. Anesthetic agents may depress ventricular function, resulting in concern for rejection. The aim of this study was to compare ventricular function as measured by echocardiography before and during GA in 17 pediatric HTx recipients. Nearly all markers of ventricular systolic function were significantly decreased under GA, including EF (-4.2% ±1.2, P < .01) and RV FAC (-0.05 ± 0.02, P = .04). Subjects in the first post-transplant year (n = 9) trended toward a more significant decrease in EF vs those beyond the first post-transplant year (n = 8; -6.0% ±1.2 vs -2.1 ± 2.0, P = .1). This information quantifies a decline in biventricular function that should be expected in pediatric HTx recipients while under GA and can assist the transplant clinician in avoiding unnecessary treatment of transient GA-induced ventricular dysfunction.
authors: Division of Pediatric Cardiology, Department of Pediatrics, Medical University of South Carolina, Charleston, SC, USA.
authors: Justin J
authors: JJ
authors: Elhoff
authors: Division of Pediatric Cardiology, Department of Pediatrics, Medical University of South Carolina, Charleston, SC, USA.
authors: Shahryar M
authors: SM
authors: Chowdhury
authors: Division of Pediatric Cardiology, Department of Pediatrics, Medical University of South Carolina, Charleston, SC, USA.
authors: Carolyn L
authors: CL
authors: Taylor
authors: Division of Pediatric Anesthesia, Department of Anesthesia and Perioperative Medicine, Medical University of South Carolina, Charleston, SC, USA.
authors: Marc
authors: M
authors: Hassid
authors: Division of Pediatric Cardiology, Department of Pediatrics, Medical University of South Carolina, Charleston, SC, USA.
authors: Andrew J
authors: AJ
authors: Savage
authors: Division of Pediatric Cardiology, Department of Pediatrics, Medical University of South Carolina, Charleston, SC, USA.
authors: Andrew M
authors: AM
authors: Atz
authors: Division of Pediatric Cardiology, Department of Pediatrics, Medical University of South Carolina, Charleston, SC, USA.
authors: Ryan J
authors: RJ
authors: Butts
mesh_terms: D000293:Adolescent; D000768:Anesthesia, General / Q000009:adverse effects*; D000777:Anesthetics / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D003971:Diastole; D004452:Echocardiography; D005260:Female; D016027:Heart Transplantation; D006352:Heart Ventricles / Q000503:physiopathology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D013599:Systole; D016276:Ventricular Function; D055815:Young Adult
chemical_list: D000777:Anesthetics
keywords: anesthesia; cardiac function; echocardiography; graft function; pediatric heart transplant