title: Clinical and radiological correlations in patients with gestational trophoblastic disease.
abstract: Gestational trophoblastic disease is an abnormality of pregnancy that encompasses a group of diseases that differ from each other in their propensity for regression, invasion, metastasis, and recurrence. In the past, it was common for patients with molar pregnancy to present with marked symptoms: copious bleeding; theca lutein cysts; uterus larger than appropriate for gestational age; early preeclampsia; hyperemesis gravidarum; and hyperthyroidism. Currently, with early diagnosis made by ultrasound, most patients are diagnosed while the disease is still in the asymptomatic phase. In cases of progression to trophoblastic neoplasia, staging-typically with Doppler flow studies of the pelvis and chest X-ray, although occasionally with computed tomography or magnetic resonance imaging-is critical to the choice of an appropriate antineoplastic therapy regimen. Because it is an unusual and serious disease that affects women of reproductive age, as well as because its appropriate treatment results in high cure rates, it is crucial that radiologists be familiar with gestational trophoblastic disease, in order to facilitate its early diagnosis and to ensure appropriate follow-up imaging.
authors: Master's Student in the Perinatal Health Program at the Faculdade de Medicina da Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil.
authors: Lana de Lourdes Aguiar
authors: LL
authors: Lima
authors: PhD, Physician at the Gynecology Institute of the Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil.
authors: Raphael Câmara Medeiros
authors: RC
authors: Parente
authors: PhD, Adjunct Professor of Obstetrics at the Faculdade de Medicina da Universidade Estadual Paulista "Júlio de Mesquita Filho" (Unesp), Botucatu, SP, Brazil.
authors: Izildinha
authors: I
authors: Maestá
authors: PhD, Associate Professor of Obstetrics at the Faculdade de Medicina da Universidade Federal do Rio de Janeiro (UFRJ), Director of the Maternidade Escola da Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil.
authors: Joffre
authors: J
authors: Amim Junior
authors: PhD, Full Professor of Obstetrics at the Faculdade de Medicina da Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil.
authors: Jorge Fonte
authors: JF
authors: de Rezende Filho
authors: PhD, Full Member Emeritus of the Academia Nacional de Medicina, Full Professor of Obstetrics at the Faculdade de Medicina da Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil.
authors: Carlos Antonio Barbosa
authors: CA
authors: Montenegro
authors: PhD, Adjunct Professor of Obstetrics at the Faculdade de Medicina da Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, and at the Faculdade de Medicina da Universidade Federal Fluminense (UFF), Niterói, RJ, Brazil.
authors: Antônio
authors: A
authors: Braga
keywords: Gestational trophoblastic disease; Hydatidiform mole; Radiology