title: Synergistic effect of sunlight induced photothermal conversion and H2O2release based on hybridized tungsten oxide gel for cancer inhibition.
abstract: A highly efficient photochromic hydrogel was successfully fabricated via casting precursor, which is based on amorphous tungsten oxide and poly (ethylene oxide)-block-poly (propylene oxide)-block-poly (ethylene oxide). Under simulated solar illumination, the hydrogel has a rapid and controlled temperature increasing ratio as its coloration degree. Localized electrons in the amorphous tungsten oxide play a vital role in absorption over a broad range of wavelengths from 400 nm to 1100 nm, encompassing the entire visible light and infrared regions in the solar spectrum. More importantly, the material exhibits sustainable released H2O2induced by localized electrons, which has a synergistic effect with the rapid surface temperature increase. The amount of H2O2released by each film can be tuned by the light irradiation, and the film coloration can indicate the degree of oxidative stress. The ability of the H2O2-releasing gels in vitro study was investigated to induce apoptosis in melanoma tumor cells and NIH 3T3 fibroblasts. The in vivo experimental results indicate that these gels have a greater healing effect than the control in the early stages of tumor formation.
authors: Institute of Microstructure and Property of Advanced Materials, Beijing University of Technology, Beijing 100124, China.|Department of Physics, The Hong Kong University of Science and Technology, Clear water bay, Kowloon, Hong Kong.
authors: Cong
authors: C
authors: Wang
authors: Division of Environmental Science, The Hong Kong University of Science and Technology, Clear water bay, Kowloon, Hong Kong.
authors: Yibo
authors: Y
authors: Gao
authors: Shenzhen PKU-HKUST Medical Center, Biomedical Research Institute, Shenzhen-PKU-HKUST Medical Center, Shenzhen, China.|Materials Genome Institute, Shanghai University, Shanghai 200444, China.
authors: Xinghua
authors: X
authors: Gao
authors: Department of Laboratory Medicine, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
authors: Hua
authors: H
authors: Wang
authors: Department of Physics, The Hong Kong University of Science and Technology, Clear water bay, Kowloon, Hong Kong.
authors: Jingxuan
authors: J
authors: Tian
authors: Department of Physics, The Hong Kong University of Science and Technology, Clear water bay, Kowloon, Hong Kong.
authors: Li
authors: L
authors: Wang
authors: Department of Physics, The Hong Kong University of Science and Technology, Clear water bay, Kowloon, Hong Kong.|Institute of Applied Physics and Materials Engineering, University of Macau, Taipa, Macau.
authors: Bingpu
authors: B
authors: Zhou
authors: Department of Physics, The Hong Kong University of Science and Technology, Clear water bay, Kowloon, Hong Kong.
authors: Ziran
authors: Z
authors: Ye
authors: Shenzhen PKU-HKUST Medical Center, Biomedical Research Institute, Shenzhen-PKU-HKUST Medical Center, Shenzhen, China.
authors: Jun
authors: J
authors: Wan
authors: Department of Physics, The Hong Kong University of Science and Technology, Clear water bay, Kowloon, Hong Kong.|Division of Environmental Science, The Hong Kong University of Science and Technology, Clear water bay, Kowloon, Hong Kong.|Materials Genome Institute, Shanghai University, Shanghai 200444, China.
authors: Weijia
authors: W
authors: Wen
mesh_terms: D000818:Animals; D017209:Apoptosis; D002460:Cell Line; D004195:Disease Models, Animal; D004358:Drug Therapy / Q000379:methods*; D006358:Hot Temperature; D006801:Humans; D020100:Hydrogels / Q000378:metabolism*; D006861:Hydrogen Peroxide / Q000378:metabolism*; D006979:Hyperthermia, Induced / Q000379:methods*; D008545:Melanoma / Q000628:therapy*; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D016877:Oxidants / Q000378:metabolism; D010087:Oxides / Q000378:metabolism*; D013472:Sunlight; D016896:Treatment Outcome; D014414:Tungsten / Q000378:metabolism*
chemical_list: D020100:Hydrogels; D016877:Oxidants; D010087:Oxides; C511604:tungsten oxide; D006861:Hydrogen Peroxide; D014414:Tungsten