title: Safety and Clinical Outcomes of Catheter Ablation of Atrial Fibrillation in Patients With Chronic Kidney Disease.
abstract: Data regarding catheter ablation of atrial fibrillation (AF) in patients with chronic kidney disease (CKD) is limited. We therefore assessed the association of CKD with common safety and clinical outcomes in a nationwide sample of ablation recipients.
  
  
  
  Using MarketScan®Commercial Claims and Medicare Supplemental Databases, we evaluated 30-day safety and 1-year clinical outcomes in patients who underwent a first AF ablation procedure between 2007 and 2011. We calculated frequency of common 30-day complications and calculated frequencies, incidence rates, and Cox proportional hazards for outcomes at 1-year postablation.
  
  
  
  Of 21,091 patients included, 1,593 (7.6%) had CKD. Patients with CKD were older (64 years vs. 59 years, P < 0.001) with higher CHA2DS2-VASc scores (3.2 vs. 1.8, P < 0.001). At 30 days postablation, patients with CKD had similar rates of stroke/TIA (0.13% vs. 0.13%, P = 0.99), perforation/tamponade (3.2% vs. 3.1%, P = 0.83), and vascular complications (2.4% vs. 2.2%, P = 0.59) as patients without CKD, but were more likely to be hospitalized for heart failure (2.1% vs. 0.4%, P < 0.001). In multivariate analysis, there were no significant differences in hazards of AF hospitalization (adjusted HR: 1.02, 95%CI: 0.87-1.20), cardioversion (adjusted HR: 0.99, 95%CI: 0.87-1.12), or repeat AF ablation (adjusted HR: 0.89, 95%CI: 0.76-1.06) at 1 year.
  
  
  
  Among patients selected for AF ablation, those with and without CKD had similar rates of postprocedural complications although they were more likely to be re-admitted for heart failure. CKD was not independently associated with AF hospitalization, cardioversion, and repeat ablation. These findings can inform clinical decision-making in patients with AF and CKD.
authors: Veterans Affairs Palo Alto Health Care System, Palo Alto, USA.|Stanford University School of Medicine, Stanford, California, USA.
authors: Aditya J
authors: AJ
authors: Ullal
authors: Stanford University School of Medicine, Stanford, California, USA.
authors: Daniel W
authors: DW
authors: Kaiser
authors: Veterans Affairs Palo Alto Health Care System, Palo Alto, USA.
authors: Jun
authors: J
authors: Fan
authors: Veterans Affairs Palo Alto Health Care System, Palo Alto, USA.
authors: Susan K
authors: SK
authors: Schmitt
authors: Veterans Affairs Palo Alto Health Care System, Palo Alto, USA.
authors: Claire T
authors: CT
authors: Than
authors: Baylor College of Medicine, Houston, Texas, USA.
authors: Wolfgang C
authors: WC
authors: Winkelmayer
authors: Veterans Affairs Palo Alto Health Care System, Palo Alto, USA.|Stanford University School of Medicine, Stanford, California, USA.
authors: Paul A
authors: PA
authors: Heidenreich
authors: Duke University Medical Center, Durham, North Carolina, USA.
authors: Jonathan P
authors: JP
authors: Piccini
authors: Stanford University School of Medicine, Stanford, California, USA.
authors: Marco V
authors: MV
authors: Perez
authors: Stanford University School of Medicine, Stanford, California, USA.
authors: Paul J
authors: PJ
authors: Wang
authors: Veterans Affairs Palo Alto Health Care System, Palo Alto, USA.|Stanford University School of Medicine, Stanford, California, USA.
authors: Mintu P
authors: MP
authors: Turakhia
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001281:Atrial Fibrillation / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology / Q000601:surgery*; D017115:Catheter Ablation / Q000009:adverse effects; D015897:Comorbidity; D016208:Databases, Factual; D018572:Disease-Free Survival; D005260:Female; D006333:Heart Failure / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010359:Patient Readmission; D016016:Proportional Hazards Models; D012008:Recurrence; D051436:Renal Insufficiency, Chronic / Q000175:diagnosis / Q000453:epidemiology*; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome; D014481:United States / Q000453:epidemiology; D055815:Young Adult
keywords: atrial fibrillation; catheter ablation; chronic kidney disease; safety; stroke