title: Genes involved in the establishment of hepatic steatosis in Muscovy, Pekin and mule ducks.
abstract: Our main objectives were to determine the genes involved in the establishment of hepatic steatosis in three genotypes of palmipeds. To respond to this question, we have compared Muscovy ducks, Pekin ducks and their crossbreed the mule duck fed ad libitum or overfed. We have shown a hepatic overexpression of fatty acid synthase (FAS) and di-acyl glycerol acyl transferase 2 (DGAT2) in overfed individuals, where DGAT2 seemed to be more regulated. This increase in lipogenesis genes is associated with a decrease of lipoprotein formation in Muscovy and mule ducks, especially apolipoprotein B (ApoB) and Microsomal Triglyceride Transfer Protein (MTTP), leading to lipid accumulation in liver. In Pekin ducks, MTTP expression is upregulated suggesting a better hepatic lipids exportation. Regarding lipids re-uptake, fatty acid-binding protein 4 and very-low-density-lipoprotein receptor are overexpressed in liver of mule ducks at the end of the overfeeding period. This phenomenon puts light on a mechanism unknown until today. In fact, mule can incorporate more lipids in liver than the two other genotypes leading to an intensified hepatic steatosis. To conclude, our results confirmed the genotype variability to overfeeding. Furthermore, similar observations are already described in non-alcoholic fatty liver disease in human, and ask if ducks could be an animal model to study hepatic triglyceride accumulation.
authors: UMR 1419 INRA UPPA NuMéA, 371 Rue du Ruisseau, Mont De Marsan, 40000, France.|UMR 1419 INRA UPPA NuMéA, Quartier Ibarron, Saint Pée Sur Nivelle, 64310, France.
authors: Annabelle
authors: A
authors: Tavernier
authors: UMR 1419 INRA UPPA NuMéA, 371 Rue du Ruisseau, Mont De Marsan, 40000, France.|UMR 1419 INRA UPPA NuMéA, Quartier Ibarron, Saint Pée Sur Nivelle, 64310, France.
authors: Stéphane
authors: S
authors: Davail
authors: UMR 1419 INRA UPPA NuMéA, 371 Rue du Ruisseau, Mont De Marsan, 40000, France.|UMR 1419 INRA UPPA NuMéA, Quartier Ibarron, Saint Pée Sur Nivelle, 64310, France.
authors: Karine
authors: K
authors: Ricaud
authors: INRA UEPFG, 1076 Route de Haut Mauco, Benquet, 40280, France.
authors: Marie-Dominique
authors: MD
authors: Bernadet
authors: UMR 1419 INRA UPPA NuMéA, 371 Rue du Ruisseau, Mont De Marsan, 40000, France. karine.gontier@univ-pau.fr.|UMR 1419 INRA UPPA NuMéA, Quartier Ibarron, Saint Pée Sur Nivelle, 64310, France. karine.gontier@univ-pau.fr.
authors: Karine
authors: K
authors: Gontier
mesh_terms: D000818:Animals; D030161:Avian Proteins / Q000235:genetics / Q000378:metabolism; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism; D004372:Ducks / Q000235:genetics / Q000378:metabolism; D050556:Fatty Acid-Binding Proteins / Q000235:genetics / Q000378:metabolism; D005234:Fatty Liver / Q000235:genetics / Q000378:metabolism / Q000662:veterinary; D006801:Humans; D011201:Poultry Diseases / Q000235:genetics / Q000378:metabolism; D011973:Receptors, LDL / Q000235:genetics / Q000378:metabolism
chemical_list: D030161:Avian Proteins; D002352:Carrier Proteins; D050556:Fatty Acid-Binding Proteins; D011973:Receptors, LDL; C036053:VLDL receptor; C106092:microsomal triglyceride transfer protein
keywords: Ducks; Gene expression; Hepatic steatosis; Lipids; NAFLD