title: Comparison of Spectra Optia and COBE Spectra apheresis systems' performances for red blood cell exchange procedures.
abstract: BACKGROUND
  Spectra Optia (Terumo BCT, Lakewood, CO) was FDA approved for red blood cell exchange (RBCx) procedures in January 2014 and is expected to replace COBE spectra (Terumo BCT) very soon in the USA. The performance characteristics of these devices for Isovolemic Hemodilution (IHD-RBCx) procedure were compared in this study.
  
  
  METHODS
  A total of 114 IHD-RBCx procedures from 19 patients were analyzed. For every patient, three procedures on each device with similar pre-procedure hematocrits were compared. Pre and post procedure laboratory parameters compared were hemoglobin S (HbS), hematocrits (Hct), platelet counts and fraction of cells remaining (FCR). Statistical analysis was performed using t-test adjusted by the Holm-Bonferroni method to reduce family-wise error rate.
  
  
  RESULTS
  There were no significant differences between these two devices in regards to HbS, Hct, FCR and platelet counts (p = > 0.05). However, rinseback volume (124.2 ± 8.9 ml) and normal saline replacement volume during IHD phase (296.1 ± 97.2 ml) were lower in Spectra Optia as compared to COBE Spectra (337 ± 33.8 ml and 326.6 ± 105.2 ml, p value <0.001 and 0.030 respectively). Spectra Optia had a longer run time (107.1 ± 15.9 min vs 123.8 ± 19.6 min, p value <0.001) overall.
  
  
  CONCLUSIONS
  Performance characteristics of Spectra Optia for HbS, Hct and FCR were similar to COBE Spectra for IHD-RBCx. IHD-RBCx procedure on Optia required less normal saline replacement volume and rinse back volume but with overall longer procedure run time.
authors: Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
authors: Jaehyup
authors: J
authors: Kim
authors: Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
authors: Ranjit
authors: R
authors: Joseph
authors: Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
authors: Karen
authors: K
authors: Matevosyan
authors: Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: ravi.sarode@utsouthwestern.edu.
authors: Ravi
authors: R
authors: Sarode
mesh_terms: D000328:Adult; D001781:Blood Component Removal / Q000009:adverse effects / Q000379:methods*; D004912:Erythrocytes / Q000166:cytology*; D005260:Female; D006438:Hemodilution; D006801:Humans; D008297:Male; D013057:Spectrum Analysis / Q000379:methods*; D055815:Young Adult
keywords: COBE Spectra; Red blood cell exchange; Sickle cell anemia; Spectra Optia