title: The predictive value of plasma catestatin for all-cause and cardiac deaths in chronic heart failure patients.
abstract: Catestatin (CST) is a proteolytic fragment of Chromogranin A with a broad spectrum of activities in the cardiovascular system. The level of plasma CST increases in chronic heart failure patients, but its potential relationship to patient prognosis is unknown. In this study, we measured plasma CST levels in 202 chronic heart failure patients and followed them for a median of 52.5 months. The plasma CST level was higher in patients with all-cause death and cardiac death than in survivors. According to univariate COX regression, higher plasma CST levels predicted increased risk of all-cause and cardiac death. After adjustment for other confounding factors, plasma CST was an independent risk factor for both outcomes, and the hazard ratios (HRs) were 1.84 (95% CI: 1.02-3.32, p=0.042) and 2.41 (95% CI: 1.26-4.62, p=0.008) for all-cause death and cardiac death, respectively. The new risk-predictive model considering CST was superior to the previous model for both outcomes by ANOVA and likelihood ratio tests (p=0.040 and p=0.008, respectively). Concurrent increases in plasma BNP (B-type natriuretic peptide) and CST levels predicted the highest risk for both all-cause and cardiac deaths [HR=5.18 (95% CI: 1.94-13.87, p=0.001) and HR=9.19 (95% CI: 2.75-30.78, p<0.001), respectively]. Large-scale studies are needed to further assess the value of plasma CST in predicting heart failure prognosis.
authors: Department of Cardiology, Peking University First Hospital, No. 8, Xishiku Street, West District, Beijing, 100034, PR China.
authors: Fen
authors: F
authors: Peng
authors: Department of Cardiology, Peking University First Hospital, No. 8, Xishiku Street, West District, Beijing, 100034, PR China.
authors: Songyun
authors: S
authors: Chu
authors: Department of Cardiology, Peking University First Hospital, No. 8, Xishiku Street, West District, Beijing, 100034, PR China. Electronic address: dwh_rd@126.com.
authors: Wenhui
authors: W
authors: Ding
authors: Department of Cardiology, Peking University First Hospital, No. 8, Xishiku Street, West District, Beijing, 100034, PR China.
authors: Lin
authors: L
authors: Liu
authors: Department of Cardiology, Peking University First Hospital, No. 8, Xishiku Street, West District, Beijing, 100034, PR China.
authors: Jing
authors: J
authors: Zhao
authors: Department of Cardiology, Peking University First Hospital, No. 8, Xishiku Street, West District, Beijing, 100034, PR China.
authors: Xiaojing
authors: X
authors: Cui
authors: Department of Cardiology, Peking University First Hospital, No. 8, Xishiku Street, West District, Beijing, 100034, PR China.
authors: Renxu
authors: R
authors: Li
authors: Department of Cardiology, Peking University First Hospital, No. 8, Xishiku Street, West District, Beijing, 100034, PR China.
authors: Jie
authors: J
authors: Wang
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D053379:Chromogranin A / Q000097:blood*; D005260:Female; D006333:Heart Failure / Q000097:blood* / Q000401:mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D020097:Natriuretic Peptide, Brain / Q000097:blood; D010446:Peptide Fragments / Q000097:blood*; D016016:Proportional Hazards Models
chemical_list: D015415:Biomarkers; D053379:Chromogranin A; D010446:Peptide Fragments; C109084:chromogranin A (344-364); D020097:Natriuretic Peptide, Brain
keywords: All-cause death; Cardiac death; Catestatin; Heart failure; Prognosis