title: Molecular Pathogenesis of Hepatocellular Carcinoma.
abstract: The pathogenesis of hepatocellular carcinoma (HCC) is a multistep process involving the progressive accumulation of molecular alterations pinpointing different molecular and cellular events. The next-generation sequencing technology is facilitating the global and systematic evaluation of molecular landscapes in HCC. There is emerging evidence supporting the importance of cancer metabolism and tumor microenvironment in providing a favorable and supportive niche to expedite HCC development. Moreover, recent studies have identified distinct surface markers of cancer stem cell (CSC) in HCC, and they also put forward the profound involvement of altered signaling pathways and epigenetic modifications in CSCs, in addition to the concomitant drug resistance and metastasis. Taken together, multiple key genetic and non-genetic factors, as well as liver CSCs, result in the development and progression of HCC.
authors: Department of Pathology, The University of Hong Kong, Hong Kong, SAR, China; State Key Laboratory for Liver Research, The University of Hong Kong, Hong Kong, SAR, China.
authors: Daniel Wai-Hung
authors: DW
authors: Ho
authors: Department of Pathology, The University of Hong Kong, Hong Kong, SAR, China; State Key Laboratory for Liver Research, The University of Hong Kong, Hong Kong, SAR, China.
authors: Regina Cheuk-Lam
authors: RC
authors: Lo
authors: Department of Pathology, The University of Hong Kong, Hong Kong, SAR, China; State Key Laboratory for Liver Research, The University of Hong Kong, Hong Kong, SAR, China.
authors: Lo-Kong
authors: LK
authors: Chan
authors: Department of Pathology, The University of Hong Kong, Hong Kong, SAR, China; State Key Laboratory for Liver Research, The University of Hong Kong, Hong Kong, SAR, China.
authors: Irene Oi-Lin
authors: IO
authors: Ng
keywords: Cancer stem cells; Hepatocellular carcinoma; Molecular alterations; Next-generation sequencing