title: Ubiquitin in Influenza Virus Entry and Innate Immunity.
abstract: Viruses are obligatory cellular parasites. Their mission is to enter a host cell, to transfer the viral genome, and to replicate progeny whilst diverting cellular immunity. The role of ubiquitin is to regulate fundamental cellular processes such as endocytosis, protein degradation, and immune signaling. Many viruses including influenza A virus (IAV) usurp ubiquitination and ubiquitin-like modifications to establish infection. In this focused review, we discuss how ubiquitin and unanchored ubiquitin regulate IAV host cell entry, and how histone deacetylase 6 (HDAC6), a cytoplasmic deacetylase with ubiquitin-binding activity, mediates IAV capsid uncoating. We also discuss the roles of ubiquitin in innate immunity and its implications in the IAV life cycle.
authors: Institute of Molecular Life Sciences, University of Zurich, Winterthurerstrasse 190, Zurich CH-8057, Switzerland. alinaewa.rudnicka@uzh.ch.
authors: Alina
authors: A
authors: Rudnicka
authors: Institute of Molecular Life Sciences, University of Zurich, Winterthurerstrasse 190, Zurich CH-8057, Switzerland. yohei.yamauchi@bristol.ac.uk.|School of Cellular and Molecular Medicine, University of Bristol, Biomedical Sciences Building, University Walk, Bristol BS8 1TD, UK. yohei.yamauchi@bristol.ac.uk.|Structural Biology Research Center, Department of Biological Science, Graduate School of Science, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8602, Japan. yohei.yamauchi@bristol.ac.uk.
authors: Yohei
authors: Y
authors: Yamauchi
mesh_terms: D000818:Animals; D006655:Histone Deacetylases / Q000378:metabolism; D054884:Host-Pathogen Interactions; D006801:Humans; D007113:Immunity, Innate; D009980:Influenza A virus / Q000276:immunology* / Q000502:physiology*; D025801:Ubiquitin / Q000378:metabolism*; D053586:Virus Internalization; D057646:Virus Uncoating
chemical_list: D025801:Ubiquitin; D006655:Histone Deacetylases
keywords: HDAC6; aggresome processing; influenza virus; innate immunity; ubiquitin; unanchored ubiquitin; virus entry; virus uncoating; virus–host interactions