title: A neuronal PI(3,4,5)P3-dependent program of oligodendrocyte precursor recruitment and myelination.
abstract: The molecular trigger of CNS myelination is unknown. By targeting Pten in cerebellar granule cells and activating the AKT1-mTOR pathway, we increased the caliber of normally unmyelinated axons and the expression of numerous genes encoding regulatory proteins. This led to the expansion of genetically wild-type oligodendrocyte progenitor cells, oligodendrocyte differentiation and de novo myelination of parallel fibers. Thus, a neuronal program dependent on the phosphoinositide PI(3,4,5)P3is sufficient to trigger all steps of myelination.
authors: Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Göttingen, Germany.
authors: Sandra
authors: S
authors: Goebbels
authors: Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Göttingen, Germany.
authors: Georg L
authors: GL
authors: Wieser
authors: Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Göttingen, Germany.
authors: Alexander
authors: A
authors: Pieper
authors: Wellcome Trust-MRC Stem Cell Institute, Cambridge Centre for Brain Repair, and Department of Veterinary Medicine, University of Cambridge, UK.
authors: Sonia
authors: S
authors: Spitzer
authors: Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Göttingen, Germany.
authors: Bettina
authors: B
authors: Weege
authors: Charité-Universitätsmedizin Berlin, Institute of Cell Biology and Neurobiology, NeuroCure Cluster of Excellence, Berlin, Germany.
authors: Kuo
authors: K
authors: Yan
authors: Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Göttingen, Germany.
authors: Julia M
authors: 0000-0002-3869-0962
authors: JM
authors: Edgar
authors: Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Göttingen, Germany.
authors: Oleksandr
authors: O
authors: Yagensky
authors: Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Göttingen, Germany.
authors: Sven P
authors: SP
authors: Wichert
authors: Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Göttingen, Germany.
authors: Amit
authors: 0000-0001-7948-4498
authors: A
authors: Agarwal
authors: Universitätsmedizin Mainz, Institute for Molecular Medicine, Mainz, Germany.
authors: Khalad
authors: K
authors: Karram
authors: Laboratory of Brain Development and Repair, The Rockefeller University, New York, USA.
authors: Nicolas
authors: N
authors: Renier
authors: Laboratory of Brain Development and Repair, The Rockefeller University, New York, USA.
authors: Marc
authors: M
authors: Tessier-Lavigne
authors: Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Göttingen, Germany.
authors: Moritz J
authors: MJ
authors: Rossner
authors: Wellcome Trust-MRC Stem Cell Institute, Cambridge Centre for Brain Repair, and Department of Veterinary Medicine, University of Cambridge, UK.
authors: Ragnhildur Thóra
authors: 0000-0001-9675-2722
authors: RT
authors: Káradóttir
authors: Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Göttingen, Germany.
authors: Klaus-Armin
authors: KA
authors: Nave
mesh_terms: D000818:Animals; D001369:Axons / Q000378:metabolism*; D002454:Cell Differentiation / Q000235:genetics / Q000502:physiology; D008822:Mice, Transgenic; D009186:Myelin Sheath / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism*; D009836:Oligodendroglia / Q000166:cytology*; D010716:Phosphatidylinositols / Q000378:metabolism*
chemical_list: D009419:Nerve Tissue Proteins; D010716:Phosphatidylinositols; C118303:phosphoinositide-3,4,5-triphosphate