title: Bioreactor-Based Tumor Tissue Engineering.
abstract: This review focuses on modeling of cancer tumors using tissue engineering technology. Tumor tissue engineering (TTE) is a new method of three-dimensional (3D) simulation of malignant neoplasms. Design and development of complex tissue engineering constructs (TECs) that include cancer cells, cell-bearing scaffolds acting as the extracellular matrix, and other components of the tumor microenvironment is at the core of this approach. Although TECs can be transplanted into laboratory animals, the specific aim of TTE is the most realistic reproduction and long-term maintenance of the simulated tumor propertiesin vitrofor cancer biology research and for the development of new methods of diagnosis and treatment of malignant neoplasms. Successful implementation of this challenging idea depends on bioreactor technology, which will enable optimization of culture conditions and control of tumor TECs development. In this review, we analyze the most popular bioreactor types in TTE and the emerging applications.
authors: Macquarie University, Sydney, 2109, New South Wales, Australia ; ARC Centre of Excellence for Nanoscale BioPhotonics, Macquarie University, Sydney 2109, New South Wales, Australia ; Sechenov First Moscow State Medical University, Institute for Regenerative Medicine, 8, Trubetskaya Str., Moscow, 119992, Russia ; Lobachevsky Nizhniy Novgorod State University, 23, Gagarina Ave., Nizhniy Novgorod, 603950, Russia.
authors: A E
authors: AE
authors: Guller
authors: Inetex LTD, 10, Plaut Str., Rehovot, 76706, Israel.
authors: P N
authors: PN
authors: Grebenyuk
authors: Sechenov First Moscow State Medical University, Institute for Regenerative Medicine, 8, Trubetskaya Str., Moscow, 119992, Russia.
authors: A B
authors: AB
authors: Shekhter
authors: Macquarie University, Sydney, 2109, New South Wales, Australia ; ARC Centre of Excellence for Nanoscale BioPhotonics, Macquarie University, Sydney 2109, New South Wales, Australia ; Sechenov First Moscow State Medical University, Institute for Regenerative Medicine, 8, Trubetskaya Str., Moscow, 119992, Russia ; Lobachevsky Nizhniy Novgorod State University, 23, Gagarina Ave., Nizhniy Novgorod, 603950, Russia.
authors: A V
authors: AV
authors: Zvyagin
authors: Lobachevsky Nizhniy Novgorod State University, 23, Gagarina Ave., Nizhniy Novgorod, 603950, Russia ; Institute of Bioorganic Chemistry, 16/10, Miklukho-Maklaya Str., Moscow, 117871, Russia ; National Research Tomsk Polytechnic University, 30, Lenina Ave., Tomsk, 634050, Russia.
authors: S M
authors: SM
authors: Deyev
keywords: bioreactors; cancer; models; tissue engineering