title: Coriandrum sativum Suppresses Aβ42-Induced ROS Increases, Glial Cell Proliferation, and ERK Activation.
abstract: Alzheimer's disease (AD), the most common neurodegenerative disease, has a complex and widespread pathology that is characterized by the accumulation of amyloid [Formula: see text]-peptide (A[Formula: see text]) in the brain and various cellular abnormalities, including increased oxidative damage, an amplified inflammatory response, and altered mitogen-activated protein kinase signaling. Based on the complex etiology of AD, traditional medicinal plants with multiple effective components are alternative treatments for patients with AD. In the present study, we investigated the neuroprotective effects of an ethanol extract of Coriandrum sativum (C. sativum) leaves on A[Formula: see text] cytotoxicity and examined the molecular mechanisms underlying the beneficial effects. Although recent studies have shown the benefits of the inhalation of C. sativum oil in an animal model of AD, the detailed molecular mechanisms by which C. sativum exerts its neuroprotective effects are unclear. Here, we found that treatment with C. sativum extract increased the survival of both A[Formula: see text]-treated mammalian cells and [Formula: see text]42-expressing flies. Moreover, C. sativum extract intake suppressed [Formula: see text]-induced cell death in the larval imaginal disc and brain without affecting A[Formula: see text]42 expression and accumulation. Interestingly, the increases in reactive oxygen species levels and glial cell number in AD model flies were reduced by C. sativum extract intake. Additionally, C. sativum extract inhibited the epidermal growth factor receptor- and A[Formula: see text]-induced phosphorylation of extracellular signal-regulated kinase (ERK). The constitutively active form of ERK abolished the protective function of C. sativum extract against the [Formula: see text]-induced eye defect phenotype in Drosophila. Taken together, these results suggest that C. sativum leaves have antioxidant, anti-inflammatory, and ERK signaling inhibitory properties that are beneficial for patients with AD.
authors: * Department of Oriental Medicine, Dongguk University, Gyeogju 38066, Republic of Korea.|† Department of Oriental Neuropsychiatry, Graduate School of Oriental Medicine, Republic of Korea.
authors: Quan Feng
authors: QF
authors: Liu
authors: ‡ Department of Biological Sciences, Konkuk University, Seoul 05029, Republic of Korea.
authors: Haemin
authors: H
authors: Jeong
authors: ‡ Department of Biological Sciences, Konkuk University, Seoul 05029, Republic of Korea.
authors: Jang Ho
authors: JH
authors: Lee
authors: ‡ Department of Biological Sciences, Konkuk University, Seoul 05029, Republic of Korea.
authors: Yoon Ki
authors: YK
authors: Hong
authors: * Department of Oriental Medicine, Dongguk University, Gyeogju 38066, Republic of Korea.|† Department of Oriental Neuropsychiatry, Graduate School of Oriental Medicine, Republic of Korea.
authors: Youngje
authors: Y
authors: Oh
authors: § College of Pharmacy and BK21PLUS R-FIND Team, Dongguk University, Goyang 10326, Republic of Korea.
authors: Young-Mi
authors: YM
authors: Kim
authors: ¶ Neurophysiology Research Group, Bio-Nano Research Centre, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Republic of Korea.
authors: Yoon Seok
authors: YS
authors: Suh
authors: ‡ Department of Biological Sciences, Konkuk University, Seoul 05029, Republic of Korea.
authors: Semin
authors: S
authors: Bang
authors: ‡ Department of Biological Sciences, Konkuk University, Seoul 05029, Republic of Korea.
authors: Hye Sup
authors: HS
authors: Yun
authors: ‡ Department of Biological Sciences, Konkuk University, Seoul 05029, Republic of Korea.|∥ Korea Hemp Institute, Konkuk University, Seoul 0529, Republic of Korea.
authors: Kyungho
authors: K
authors: Lee
authors: ‡ Department of Biological Sciences, Konkuk University, Seoul 05029, Republic of Korea.
authors: Sung Man
authors: SM
authors: Cho
authors: ** Department of Brain and Cognitive Sciences, DGIST, Daegu 42988, Republic of Korea.
authors: Sung Bae
authors: SB
authors: Lee
authors: †† Dongguk University Research Institute of Biotechnology, Dongguk University, Seoul 04620, Republic of Korea.
authors: Songhee
authors: S
authors: Jeon
authors: § College of Pharmacy and BK21PLUS R-FIND Team, Dongguk University, Goyang 10326, Republic of Korea.
authors: Young-Won
authors: YW
authors: Chin
authors: * Department of Oriental Medicine, Dongguk University, Gyeogju 38066, Republic of Korea.|† Department of Oriental Neuropsychiatry, Graduate School of Oriental Medicine, Republic of Korea.
authors: Byung-Soo
authors: BS
authors: Koo
authors: ‡ Department of Biological Sciences, Konkuk University, Seoul 05029, Republic of Korea.|∥ Korea Hemp Institute, Konkuk University, Seoul 0529, Republic of Korea.
authors: Kyoung Sang
authors: KS
authors: Cho
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy* / Q000378:metabolism; D016229:Amyloid beta-Peptides / Q000378:metabolism; D000818:Animals; D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D001921:Brain / Q000166:cytology / Q000378:metabolism; D049109:Cell Proliferation / Q000187:drug effects*; D002478:Cells, Cultured; D028526:Coriandrum / Q000737:chemistry*; D004195:Disease Models, Animal; D004330:Drosophila; D029721:Drosophila Proteins / Q000378:metabolism; D066246:ErbB Receptors / Q000378:metabolism; D020935:MAP Kinase Signaling System / Q000187:drug effects; D009457:Neuroglia / Q000166:cytology* / Q000378:metabolism*; D018696:Neuroprotective Agents; D010446:Peptide Fragments / Q000378:metabolism; D010766:Phosphorylation / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use*; D018515:Plant Leaves / Q000737:chemistry; D017382:Reactive Oxygen Species / Q000378:metabolism*; D018010:Receptors, Invertebrate Peptide / Q000378:metabolism; D012431:Rutin / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D016229:Amyloid beta-Peptides; D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D029721:Drosophila Proteins; D018696:Neuroprotective Agents; D010446:Peptide Fragments; D010936:Plant Extracts; D017382:Reactive Oxygen Species; D018010:Receptors, Invertebrate Peptide; C075222:amyloid beta-protein (1-42); D012431:Rutin; C066532:Egfr protein, Drosophila; D066246:ErbB Receptors
keywords: Alternative Medicine; Alzheimer’s Disease; Amyloid -Peptide; Animal Models; Coriandrum sativum; Extracellular Signal-Regulated Kinase