title: The copper microRNAs.
abstract: 1030 I. 1030 II. 1030 III. 1031 IV. 1031 V. 1032 VI. 1033 VII. 1034 VIII. 1034 1034 References 1034 SUMMARY: Copper (Cu) microRNAs are upregulated by Cu deficiency and mediate the post-transcriptional downregulation of transcripts that encode Cu proteins, suggesting a role directly related to Cu. However, expression and phenotypic analyses of copper microRNA mutants and over-expressors have suggested roles mainly in tolerance to abiotic stresses. To reconcile available data, a model is proposed which emphasizes the mobile nature of copper microRNA molecules in the regulation of Cu homeostasis. It is proposed that the Cu-microRNA regulatory circuits are further co-opted by plants to regulate both beneficial and pathogenic interactions with microbes. Further exploration of Cu-microRNA functions that account for the cell-to-cell mobility should give novel insight into plant microbe interactions and the integration of micronutrition and development.
authors: Biology Department, Colorado State University, Fort Collins, CO, 80523, USA.
authors: Marinus
authors: M
authors: Pilon
mesh_terms: D017124:Conserved Sequence; D003300:Copper / Q000378:metabolism*; D018506:Gene Expression Regulation, Plant; D006706:Homeostasis; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D010944:Plants / Q000235:genetics / Q000378:metabolism
chemical_list: D035683:MicroRNAs; D003300:Copper
keywords: copper (Cu); copper deficiency; copper microRNA; copper prioritization; photosynthesis; squamosa promoter binding protein-like (SPL7)