title: Four New 2-(2-Phenylethyl)chromone Derivatives from Chinese Agarwood Produced via the Whole-Tree Agarwood-Inducing Technique.
abstract: Four new 2-(2-phenylethyl)chromone derivatives (1-4) were isolated from the EtOH extract of Chinese agarwood produced via the whole-tree agarwood-inducing technique, coming fromAquilaria sinensis(Lour.) Spreng. (Thymelaeaceae). Their structures were elucidated by extensive spectroscopic methods, such as UV, IR, MS, 1D as well as 2D NMR. All of the isolates were then assessed for their anti-inflammatory activities on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7. Compound 1 exhibited significant inhibitory activity with an IC50value of 4.6 μM.
authors: Institute of Medicinal Plant Development (National Engineering Laboratory for Breeding of Endangered Medicinal Materials), Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China. yyliu@implad.ac.cn.|Hainan Branch of Institute of Medicinal Plant Development, Chinese Academy of Medicinal Sciences & Peking Union Medical College (Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine), Haikou 570311, China. yyliu@implad.ac.cn.
authors: Yang-Yang
authors: YY
authors: Liu
authors: Hainan Branch of Institute of Medicinal Plant Development, Chinese Academy of Medicinal Sciences & Peking Union Medical College (Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine), Haikou 570311, China. chendeli9999@163.com.
authors: De-Li
authors: DL
authors: Chen
authors: Institute of Medicinal Plant Development (National Engineering Laboratory for Breeding of Endangered Medicinal Materials), Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China. wjianh@263.net.|Hainan Branch of Institute of Medicinal Plant Development, Chinese Academy of Medicinal Sciences & Peking Union Medical College (Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine), Haikou 570311, China. wjianh@263.net.
authors: Jian-He
authors: JH
authors: Wei
authors: Hainan Branch of Institute of Medicinal Plant Development, Chinese Academy of Medicinal Sciences & Peking Union Medical College (Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine), Haikou 570311, China. jianfenghn@126.com.
authors: Jian
authors: J
authors: Feng
authors: Institute of Medicinal Plant Development (National Engineering Laboratory for Breeding of Endangered Medicinal Materials), Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China. 18911570328@126.com.|Hainan Branch of Institute of Medicinal Plant Development, Chinese Academy of Medicinal Sciences & Peking Union Medical College (Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine), Haikou 570311, China. 18911570328@126.com.
authors: Zheng
authors: Z
authors: Zhang
authors: Institute of Medicinal Plant Development (National Engineering Laboratory for Breeding of Endangered Medicinal Materials), Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China. yangyun43@aliyun.com.|Hainan Branch of Institute of Medicinal Plant Development, Chinese Academy of Medicinal Sciences & Peking Union Medical College (Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine), Haikou 570311, China. yangyun43@aliyun.com.
authors: Yun
authors: Y
authors: Yang
authors: Hainan Branch of Institute of Medicinal Plant Development, Chinese Academy of Medicinal Sciences & Peking Union Medical College (Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine), Haikou 570311, China. wee000123@163.com.
authors: Wei
authors: W
authors: Zheng
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002867:Chromones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000633:toxicity*; D051379:Mice; D009569:Nitric Oxide / Q000096:biosynthesis*; D000067996:RAW 264.7 Cells; D029645:Thymelaeaceae / Q000737:chemistry*
chemical_list: D000893:Anti-Inflammatory Agents; D002867:Chromones; D008070:Lipopolysaccharides; D009569:Nitric Oxide
keywords: 2-(2-phenylethyl)chromone derivatives; Aquilaria sinensis; Chinese agarwood; anti-inflammatory; whole-tree agarwood-inducing technique