title: Increasing Comorbidities Suggest that Atopic Dermatitis Is a Systemic Disorder.
abstract: Atopic dermatitis comorbidities extend well beyond the march to allergic conditions (food allergy, asthma, allergic rhinitis, allergic conjunctivitis, and eosinophilic esophagitis), suggesting both cutaneous and systemic immune activation. In reviewing atopic dermatitis comorbidities, Councilors of the International Eczema Council found a strong pattern of immune activation in peripheral blood and the propensity to both skin and systemic infections. Associations with cardiovascular, neuropsychiatric, and malignant diseases were increasingly reported, but confirmation of their link with atopic dermatitis requires longitudinal studies. Given the possibility of atopic dermatitis-related systemic immune activation, future investigations of new interventions should concurrently examine the impact on these comorbidities.
authors: The Laboratory for Investigative Dermatology, The Rockefeller University, New York, New York, USA.
authors: Patrick M
authors: PM
authors: Brunner
authors: Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
authors: Jonathan I
authors: JI
authors: Silverberg
authors: Department of Dermatology and the Laboratory for Inflammatory Skin Diseases, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
authors: Emma
authors: E
authors: Guttman-Yassky
authors: Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. Electronic address: apaller@northwestern.edu.
authors: Amy S
authors: AS
authors: Paller
authors: Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
authors: Kenji
authors: K
authors: Kabashima
authors: Department of Dermatology, Keio University School of Medicine, Tokyo, Japan.
authors: Masayuki
authors: M
authors: Amagai
authors: Department of Dermatology, University of Münster, Münster, Germany.
authors: Thomas A
authors: TA
authors: Luger
authors: Department of Dermato-Venereology, Aarhus University Hospital, Aarhus C, Denmark.
authors: Mette
authors: M
authors: Deleuran
authors: Division of Immunodermatology and Allergy Research, Department of Dermatology and Allergy, Hannover Medical School, Hannover, Germany.
authors: Thomas
authors: T
authors: Werfel
authors: Department of Dermatology and Allergy, Technical University Munich, Munich, Germany.
authors: Kilian
authors: K
authors: Eyerich
authors: Division of Immunology, Allergy and Infectious Diseases, Department of Dermatology, Medical University of Vienna, Vienna, Austria.
authors: Georg
authors: G
authors: Stingl
mesh_terms: D001249:Asthma / Q000453:epidemiology / Q000276:immunology / Q000503:physiopathology; D001424:Bacterial Infections / Q000453:epidemiology* / Q000276:immunology / Q000503:physiopathology; D015897:Comorbidity; D003233:Conjunctivitis, Allergic / Q000453:epidemiology / Q000276:immunology / Q000503:physiopathology; D003876:Dermatitis, Atopic / Q000453:epidemiology* / Q000276:immunology* / Q000503:physiopathology; D057765:Eosinophilic Esophagitis / Q000453:epidemiology / Q000276:immunology / Q000503:physiopathology; D005260:Female; D005512:Food Hypersensitivity / Q000453:epidemiology / Q000276:immunology / Q000503:physiopathology; D006801:Humans; D015994:Incidence; D008297:Male; D011379:Prognosis; D065631:Rhinitis, Allergic / Q000453:epidemiology / Q000276:immunology / Q000503:physiopathology