title: Primary Rosai-Dorfman disease of the femur.
abstract: We report a 19-year-old man with the rare occurrence of primary osseous Rosai-Dorfman disease (RDD). The patient presented with a painful, solitary, bone marrow-replacing lesion in the distal femur. A diagnosis of chronic osteomyelitis was initially made on tissue from a CT-guided needle biopsy of the lesion; however, the diagnosis of RDD was eventually made after histological and immunohistochemical analysis of material from a subsequent curettage. No lymphadenopathy or other sites of involvement were found on clinical evaluation and PET-CT. To our knowledge, this is the first report of solitary osseous RDD based on systemic staging with PET-CT. We review the clinical, imaging, and histological features of primary osseous RDD, including pitfalls in diagnosis.
authors: Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO, USA. bakerjo@mir.wustl.edu.
authors: Jonathan C
authors: JC
authors: Baker
authors: Division of Surgical Pathology, Washington University School of Medicine, St Louis, MO, USA.
authors: Michael
authors: M
authors: Kyriakos
authors: Department of Orthopedic Surgery, Washington University School of Medicine, St Louis, MO, USA.
authors: Douglas J
authors: DJ
authors: McDonald
authors: Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO, USA.
authors: David A
authors: DA
authors: Rubin
mesh_terms: D003937:Diagnosis, Differential; D015618:Histiocytosis, Sinus / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D061705:Image-Guided Biopsy; D007150:Immunohistochemistry; D008297:Male; D000072078:Positron Emission Tomography Computed Tomography; D055815:Young Adult
keywords: Bone biopsy; Rosai–Dorfman disease; Sinus histiocytosis with massive lymphadenopathy