title: Using Big Data to Discover Diagnostics and Therapeutics for Gastrointestinal and Liver Diseases.
abstract: Technologies such as genome sequencing, gene expression profiling, proteomic and metabolomic analyses, electronic medical records, and patient-reported health information have produced large amounts of data from various populations, cell types, and disorders (big data). However, these data must be integrated and analyzed if they are to produce models or concepts about physiological function or mechanisms of pathogenesis. Many of these data are available to the public, allowing researchers anywhere to search for markers of specific biological processes or therapeutic targets for specific diseases or patient types. We review recent advances in the fields of computational and systems biology and highlight opportunities for researchers to use big data sets in the fields of gastroenterology and hepatology to complement traditional means of diagnostic and therapeutic discovery.
authors: Division of Liver Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.
authors: Benjamin
authors: B
authors: Wooden
authors: Division of Liver Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York; Division of Gastroenterology and Hepatology, Department of Medical Specialties, Geneva University Hospital, Geneva, Switzerland.
authors: Nicolas
authors: N
authors: Goossens
authors: Division of Liver Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York. Electronic address: yujin.hoshida@mssm.edu.
authors: Yujin
authors: Y
authors: Hoshida
authors: Division of Liver Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.
authors: Scott L
authors: SL
authors: Friedman
mesh_terms: D015415:Biomarkers; D019295:Computational Biology; D057225:Data Mining; D055808:Drug Discovery / Q000379:methods*; D005767:Gastrointestinal Diseases / Q000175:diagnosis* / Q000188:drug therapy*; D006801:Humans; D008107:Liver Diseases / Q000175:diagnosis* / Q000188:drug therapy*; D058990:Molecular Targeted Therapy
chemical_list: D015415:Biomarkers
keywords: Big Data; Drug Repurposing; Precision Medicine; Translational Bioinformatics