title: Susceptibility to penicillin derivatives among third-generation cephalosporin-resistant Enterobacteriaceae recovered on hospital admission.
abstract: As part of the multicenter Antibiotic Therapy Optimisation Study-the largest study on the prevalence of third-generation cephalosporin-resistant Enterobacteriaceae carriage upon hospital admission-minimum inhibitory concentration values were generated for ampicillin/sulbactam, amoxicillin/clavulanic acid, piperacillin/tazobactam, mecillinam, mecillinam/clavulanic acid, and temocillin against third-generation cephalosporin-resistant Escherichia coli, Klebsiella species and Enterobacter species.
authors: German Center for Infection Research (DZIF), Germany; Division of Infectious Diseases, Department of Medicine, Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, Germany. Electronic address: alexander.mischnik@uniklinik-freiburg.de.
authors: Alexander
authors: A
authors: Mischnik
authors: German Center for Infection Research (DZIF), Germany; Division of Infectious Diseases, Department of Medicine, Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.
authors: Philipp
authors: P
authors: Baumert
authors: German Center for Infection Research (DZIF), Germany; Institute for Medical Microbiology, Immunology and Hygiene, University Hospital Cologne, Cologne, 50937, Germany.
authors: Axel
authors: A
authors: Hamprecht
authors: German Center for Infection Research (DZIF), Germany; Institute for Hygiene and Environmental Medicine, National Reference Centre for the Surveillance of Nosocomial Infections, Charité-University Hospital, Berlin, 12203, Germany.
authors: Anna
authors: A
authors: Rohde
authors: German Center for Infection Research (DZIF), Germany; Institute of Medical Microbiology and Hygiene, University of Tübingen, Tübingen, 72076, Germany.
authors: Silke
authors: S
authors: Peter
authors: German Center for Infection Research (DZIF), Germany; Institute for Medical Microbiology, Immunology and Hygiene, Technische Universität München, Munich, 81675, Germany.
authors: Susanne
authors: S
authors: Feihl
authors: German Center for Infection Research (DZIF), Germany; Institute of Medical Microbiology and Hygiene, University of Lübeck, Lübeck, 23538, Germany; Institute of Medical Microbiology, Virology and Hygiene, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
authors: Johannes
authors: J
authors: Knobloch
authors: German Center for Infection Research (DZIF), Germany; Institute for Medical Microbiology and Hygiene, University Medical Centre Freiburg, Freiburg, 79106, Germany.
authors: Hanna
authors: H
authors: Gölz
authors: German Center for Infection Research (DZIF), Germany; Institute for Hygiene and Environmental Medicine, National Reference Centre for the Surveillance of Nosocomial Infections, Charité-University Hospital, Berlin, 12203, Germany.
authors: Axel
authors: A
authors: Kola
authors: German Center for Infection Research (DZIF), Germany; Institute of Medical Microbiology and Hygiene, University of Lübeck, Lübeck, 23538, Germany.
authors: Birgit
authors: B
authors: Obermann
authors: German Center for Infection Research (DZIF), Germany; Institute for Medical Microbiology, Immunology and Hygiene, Technische Universität München, Munich, 81675, Germany.
authors: Christiane
authors: C
authors: Querbach
authors: German Center for Infection Research (DZIF), Germany; Institute of Medical Microbiology and Hygiene, University of Tübingen, Tübingen, 72076, Germany.
authors: Matthias
authors: M
authors: Willmann
authors: German Center for Infection Research (DZIF), Germany; Institute for Medical Microbiology, Immunology and Hygiene, Technische Universität München, Munich, 81675, Germany.
authors: Friedemann
authors: F
authors: Gebhardt
authors: German Center for Infection Research (DZIF), Germany; Division of Infectious Diseases, Department of Internal Medicine 1, University Hospital Tübingen, Tübingen, 72076, Germany.
authors: Evelina
authors: E
authors: Tacconelli
authors: German Center for Infection Research (DZIF), Germany; Institute for Hygiene and Environmental Medicine, National Reference Centre for the Surveillance of Nosocomial Infections, Charité-University Hospital, Berlin, 12203, Germany.
authors: Petra
authors: P
authors: Gastmeier
authors: German Center for Infection Research (DZIF), Germany; Institute for Medical Microbiology, Immunology and Hygiene, University Hospital Cologne, Cologne, 50937, Germany.
authors: Harald
authors: H
authors: Seifert
authors: German Center for Infection Research (DZIF), Germany; Division of Infectious Diseases, Department of Medicine, Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.
authors: Winfried V
authors: WV
authors: Kern
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002511:Cephalosporins / Q000494:pharmacology; D003955:Diagnostic Tests, Routine; D004755:Enterobacteriaceae / Q000187:drug effects* / Q000302:isolation & purification; D004756:Enterobacteriaceae Infections / Q000382:microbiology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D010406:Penicillins / Q000494:pharmacology*; D018440:beta-Lactam Resistance; D065093:beta-Lactamase Inhibitors / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D010406:Penicillins; D065093:beta-Lactamase Inhibitors
keywords: AmpC; Extended-spectrum β-lactamase; β-Lactamase inhibitor