title: Age-related periodontitis and alveolar bone loss in rice rats.
abstract: OBJECTIVE
  To characterize in rice rats: (a) periodontitis (PD) progress with feeding of standard laboratory rat chow (STD) during ages 4-80 weeks; and (b) PD progress with feeding of a high sucrose-casein (H-SC) diet during young adulthood.
  
  
  METHODS
  One group (N=12) was euthanized at age 4 weeks (Baseline). Four groups (N=8-16) consumed a STD diet from baseline and were necropsied at ages 22, 30, 52, and 80 weeks. Three groups (N=10-16) consumed an H-SC diet from baseline. Two were necropsied at ages 22 and 30 weeks, respectively. The third switched to the STD diet at age 22 weeks and was necropsied at age 30 weeks. All mandibles/maxillae were assessed by histometry for degree of periodontal inflammation (PD Score), alveolar crest height (ACH, mm), and horizontal alveolar bone height (hABH, mm2).
  
  
  RESULTS
  In STD diet rats aged ≥30 weeks, all endpoints were worse (P<0.05) than at Baseline. In H-SC diet rats aged ≥22 weeks, all endpoints were worse than at Baseline (P<0.05). At age 22 weeks, all endpoints were worse in the H-SC group than in the STD group (P<0.05). By age 30 weeks, the STD and H-SC groups did not differ.
  
  
  CONCLUSIONS
  1) STD diet fed rice rats develop moderate/severe PD by age 30 weeks; 2) an H-SC diet accelerates moderate/severe PD development; and 3) switching to a STD diet does not halt/reverse PD that was accelerated by an H-SC diet. These data further clarify use of the rice rat as a PD model.
authors: Department of Physiological Sciences, College of Veterinary Medicine, University of Florida (UF), Gainesville, FL 32610, United States. Electronic address: aguirrej@ufl.edu.
authors: J I
authors: JI
authors: Aguirre
authors: Osteoporosis Research Center, School of Medicine, Creighton University, Omaha, NE 68131, United States. Electronic address: mohammedakhter@creighton.edu.
authors: M P
authors: MP
authors: Akhter
authors: Department of Physiological Sciences, College of Veterinary Medicine, University of Florida (UF), Gainesville, FL 32610, United States. Electronic address: kgncfl27@yahoo.com.
authors: K G
authors: KG
authors: Neuville
authors: Department of Physiological Sciences, College of Veterinary Medicine, University of Florida (UF), Gainesville, FL 32610, United States. Electronic address: trcalekcarley@ufl.edu.
authors: C R
authors: CR
authors: Trcalek
authors: Department of Physiological Sciences, College of Veterinary Medicine, University of Florida (UF), Gainesville, FL 32610, United States. Electronic address: aleeper@ufl.edu.
authors: A M
authors: AM
authors: Leeper
authors: Department of Physiological Sciences, College of Veterinary Medicine, University of Florida (UF), Gainesville, FL 32610, United States. Electronic address: williamsaly@ufl.edu.
authors: A A
authors: AA
authors: Williams
authors: Department of Periodontology and Oral Biology, College of Dentistry, UF, United States. Electronic address: mrivera@dental.ufl.edu.
authors: M
authors: M
authors: Rivera
authors: Department of Periodontology and Oral Biology, College of Dentistry, UF, United States; Bone Research, Amgen Inc., Thousand Oaks, CA 91320, United States. Electronic address: kesavalu@dental.ufl.edu.
authors: L
authors: L
authors: Kesavalu
authors: Bone Research, Amgen Inc., Thousand Oaks, CA 91320, United States. Electronic address: huazhu.ke@ucb.com.
authors: H Z
authors: HZ
authors: Ke
authors: Bone Research, Amgen Inc., Thousand Oaks, CA 91320, United States. Electronic address: minl@amgen.com.
authors: M
authors: M
authors: Liu
authors: Department of Physiological Sciences, College of Veterinary Medicine, University of Florida (UF), Gainesville, FL 32610, United States. Electronic address: kimmeldb@comcast.net.
authors: D B
authors: DB
authors: Kimmel
mesh_terms: D016301:Alveolar Bone Loss / Q000097:blood / Q000209:etiology* / Q000473:pathology*; D000539:Alveolar Process / Q000033:anatomy & histology / Q000000981:diagnostic imaging / Q000473:pathology; D000821:Animal Feed; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight; D002784:Cholesterol / Q000097:blood; D004032:Diet; D019422:Dietary Sucrose / Q000008:administration & dosage / Q000009:adverse effects; D004195:Disease Models, Animal; D007328:Insulin / Q000097:blood; D008297:Male; D010024:Osteoporosis / Q000097:blood / Q000209:etiology* / Q000473:pathology*; D010518:Periodontitis / Q000097:blood / Q000209:etiology* / Q000473:pathology*; D011897:Random Allocation; D051381:Rats; D016205:Sigmodontinae
chemical_list: D001786:Blood Glucose; D019422:Dietary Sucrose; D007328:Insulin; D002784:Cholesterol
keywords: Alveolar crest height; High sucrose-casein diet; Mandible; Maxilla; MicroCT