title: Role of electrostatic complementarity between perylenediimide and porphyrin in highly stabilized GNA.
abstract: Relatively electron-deficient perylenediimide (PDI) and relatively electron-rich porphyrin (Por) were introduced into the middle of 16-mer glycol nucleic acid (GNA), and up to five consecutive chromophores were arranged in the zipper-like interstrand alternating fashion. Remarkable variation for the CD spectra ascribed to chromophores was observed, and bathochromic shift in the UV/Vis absorption region of chromophores occurred upon duplex formation. Interestingly, zipper-like heteroaggregates of chromophores inside had marvelous positive effects on the stabilization of the duplex, Tmof Por-PDI-Por sandwich-type modified GNA duplex was increased by 24°C in comparison with three A-T base pairs, moreover, Por-PDI-Por-PDI-Por interstrand modified GNA duplex was even stabilized by 25°C in replacement of five A-T base pairs. The specificity of high duplex stability might be driven by the strong hydrophobic electrostatic complementarity between PDI and Por face-centered stacking.
authors: Department of Chemistry, College of Science, Huazhong Agricultural University, Wuhan 430070, PR China.
authors: Yonggang
authors: Y
authors: Xiang
authors: Agricultural Bioinformatics Key Laboratory of Hubei Province, College of Informatics Huazhong Agricultural University, Wuhan 430070, PR China.
authors: Qingye
authors: Q
authors: Zhang
authors: Institute of Materials Research and Engineering, A*STAR (Agency for Science, Technology and Research), 2 Fusionopolis Way, Innovis, #08-03, Singapore 138634, Singapore. Electronic address: lizb@imre.a-star.edu.sg.
authors: Zibiao
authors: Z
authors: Li
authors: Department of Chemistry, College of Science, Huazhong Agricultural University, Wuhan 430070, PR China. Electronic address: hchenhao@mail.hzau.edu.cn.
authors: Hao
authors: H
authors: Chen
mesh_terms: D020029:Base Pairing; D002942:Circular Dichroism; D003198:Computer Simulation; D007094:Imides / Q000737:chemistry*; D010569:Perylene / Q000031:analogs & derivatives* / Q000737:chemistry; D011166:Porphyrins / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D055672:Static Electricity; D013696:Temperature
chemical_list: D007094:Imides; D011166:Porphyrins; C521332:perylenediimide; D010569:Perylene
keywords: Complementarity; Oligonucleotide; Self-assembly; Stability; Stacking