title: Emerging roles of RAC1 in treating lung cancer patients.
abstract: The Ras-related C3 botulinum toxin substrate 1 (RAC1), a member of the Rho family of small guanosine triphosphatases, is critical for many cellular activities, such as phagocytosis, adhesion, migration, motility, cell proliferation, and axonal growth. In addition, RAC1 plays an important role in cancer angiogenesis, invasion, and migration, and it has been reported to be related to most cancers, such as breast cancer, gastric cancer, testicular germ cell cancer, and lung cancer. Recently, the therapeutic target of RAC1 in cancer has been investigated. In addition, some investigations have shown that inhibition of RAC1 can reverse drug-resistance in non-small cell lung cancer. In this review, we summarize the recent advances in understanding the role of RAC1 in lung cancer and the underlying mechanisms and discuss its value in clinical therapy.
authors: Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, P.R. China.|Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha, P.R. China.
authors: T
authors: T
authors: Zou
authors: Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, P.R. China.|Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha, P.R. China.
authors: X
authors: X
authors: Mao
authors: Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, P.R. China.|Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha, P.R. China.
authors: J
authors: J
authors: Yin
authors: Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, P.R. China.|Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha, P.R. China.
authors: X
authors: X
authors: Li
authors: Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, P.R. China.|Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha, P.R. China.
authors: J
authors: J
authors: Chen
authors: Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, P.R. China.|Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha, P.R. China.
authors: T
authors: T
authors: Zhu
authors: Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, P.R. China.|Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha, P.R. China.
authors: Q
authors: Q
authors: Li
authors: Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, P.R. China.|Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha, P.R. China.
authors: H
authors: H
authors: Zhou
authors: Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, P.R. China.|Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha, P.R. China.
authors: Z
authors: Z
authors: Liu
mesh_terms: D049109:Cell Proliferation / Q000235:genetics; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D058990:Molecular Targeted Therapy; D009389:Neovascularization, Pathologic / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D020830:rac1 GTP-Binding Protein / Q000235:genetics*
chemical_list: C107953:RAC1 protein, human; D020830:rac1 GTP-Binding Protein
keywords: RAC1; cell proliferation and apoptosis; invasion; lung cancer; migration