title: Birth Weights in Sickle Cell Disease Pregnancies: A Cohort Study.
abstract: Pregnancy in women with Sickle Cell Disease (SCD) has been linked with an increased incidence of adverse foetal outcomes when compared to women without haemoglobinopathies (HbAA). There's a paucity of data into foetal outcomes for infants born to women with SCD. Customised growth charts have been demonstrated to be better than population-based growth charts at identifying unhealthy small babies. We analysed the mean birth weight and customised birth weight centiles of infants born to mothers with SCD versus mothers with HbAA genotype, to quantify the risk of having a smaller baby. Birth weight and birth weight centiles were analysed for 88 women with SCD (50 HbSS; 38 HbSC) and 176 controls (HbAA). Statistically significant differences were seen in the mean birth weight (P value = 0.004) and the mean birth weight centiles (P value = 0.016). We conclude that SCD is a risk factor for having a smaller baby.
authors: King's College London School of Medicine, London, United Kingdom.|Department of Intensive Care and Anaesthetics, Royal Sussex County Hospital, Brighton, United Kingdom.
authors: Daveena
authors: http://orcid.org/0000-0003-0044-0201
authors: D
authors: Meeks
authors: Department of Haematology, Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom.
authors: Susan E
authors: SE
authors: Robinson
authors: London School of Hygiene and Tropical Medicine, London, United Kingdom.
authors: David
authors: D
authors: Macleod
authors: King's College London School of Medicine, London, United Kingdom.|London School of Hygiene and Tropical Medicine, London, United Kingdom.|Women's Health Academic Centre, King's College London and King's Health Partners, St. Thomas' Hospital, London, United Kingdom.
authors: Eugene
authors: E
authors: Oteng-Ntim
mesh_terms: D000755:Anemia, Sickle Cell / Q000150:complications*; D001724:Birth Weight; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D011247:Pregnancy; D011248:Pregnancy Complications / Q000503:physiopathology*; D012189:Retrospective Studies