title: Liver Biochemistry During the Course of Influenza A/H1N1 Infection.
abstract: Despite the multi-systemic effects of influenza A/H1N1 virus, the occurrence of hepatic injury during the natural course of the infection remains a matter of debate. We performed a review of the published clinical studies which assess the above mentioned relationship, reviewing the studies published in PubMed database (English literature), using the key words "H1N1", "influenza A" and "liver". We excluded case reports and clinical studies that referred to pediatric and transplanted patients, pregnants and patients with known history of chronic liver diseases. From a total of 96 results, a total of 78 papers met one or more of the exclusion criteria set. Evaluating the remaining 18 published papers, 14 more were excluded as they did not provide any sufficient data, relevant to the subject of our review. Although the analysis of the remaining studies revealed the existence of conflicting results concerning the exact degree and the potential mechanisms of liver injury in H1N1 positive patients, it can be assumed that influenza A/H1N1 virus is -or at least could be- a hepatotropic virus.
authors: Department of Emergency Medicine, 401 General Army Hospital of Athens, Athens, Greece; Second Department of General Surgery, 401 General Army Hospital of Athens, Athens, Greece.
authors: Charalampos
authors: C
authors: Seretis
authors: Second Department of General Surgery, 401 General Army Hospital of Athens, Athens, Greece.
authors: Emmanuel
authors: E
authors: Lagoudianakis
authors: Second Department of General Surgery, 401 General Army Hospital of Athens, Athens, Greece.
authors: Nikolaos
authors: N
authors: Salemis
authors: Department of Internal Medicine, Argos Hospital, Argos, Greece.
authors: Apostolos
authors: A
authors: Pappas
authors: Department of Emergency Medicine, 401 General Army Hospital of Athens, Athens, Greece; Second Department of General Surgery, 401 General Army Hospital of Athens, Athens, Greece.
authors: George
authors: G
authors: Gemenetzis
authors: Department of Emergency Medicine, 401 General Army Hospital of Athens, Athens, Greece; Second Department of General Surgery, 401 General Army Hospital of Athens, Athens, Greece.
authors: Fotios
authors: F
authors: Seretis
authors: Second Department of General Surgery, 401 General Army Hospital of Athens, Athens, Greece; Intensive Care Unit, 401 General Army Hospital of Athens, Athens, Greece.
authors: Stavros
authors: S
authors: Gourgiotis
keywords: H1N1; Influenza; Liver