title: Artificially controlled degradable inorganic nanomaterial for cancer theranostics.
abstract: Multifunctional nanomaterials for cancer diagnosis and therapy have recently prompted widespread concern. To avoid nanotoxicity, the development of novel degradable functional materials must be our main focus. In this study, we firstly developed ethylenediaminetetraacetic acid calcium disodium salt (EDTA)- and bovine serum albumin (BSA)-capped Mn3O4nanoparticles (MONPs-BSA-EDTA) as a novel inorganic nanomaterials for multifunctional imaging-guided photothermal therapy, which can be degraded in a progress-controlled way by artificially introduced ascorbic acid. The degradation products can also be captured and their excretion accelerated. Careful studies suggested that the toxicity of the MONPs-BSA-EDTA and its degradation products is low. The degradation mechanism also suggests a new method of controlled drug release. The development of artificially controlled degradable inorganic nanomaterials also provides a new way to degrade nanomaterials and minimize ion release, which may have potential applications in cancer theranostics without nanotoxicity.
authors: Department of Chemistry, Capital Normal University, Beijing, 100048, PR China.
authors: Yuxin
authors: Y
authors: Liu
authors: Department of Chemistry, Capital Normal University, Beijing, 100048, PR China.
authors: Ge
authors: G
authors: Zhang
authors: Department of Chemistry, Capital Normal University, Beijing, 100048, PR China.
authors: Quanwei
authors: Q
authors: Guo
authors: Department of Chemistry, Capital Normal University, Beijing, 100048, PR China.
authors: Liyi
authors: L
authors: Ma
authors: Department of Chemistry, Capital Normal University, Beijing, 100048, PR China.
authors: Qi
authors: Q
authors: Jia
authors: Department of Chemistry, Capital Normal University, Beijing, 100048, PR China.
authors: Lidong
authors: L
authors: Liu
authors: Department of Chemistry, Capital Normal University, Beijing, 100048, PR China. Electronic address: Jingzhou@cnu.edu.cn.
authors: Jing
authors: J
authors: Zhou
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D045744:Cell Line, Tumor; D003692:Delayed-Action Preparations / Q000008:administration & dosage* / Q000737:chemistry*; D004343:Drug Implants / Q000008:administration & dosage* / Q000737:chemistry; D007287:Inorganic Chemicals / Q000737:chemistry; D008279:Magnetic Resonance Imaging / Q000379:methods; D051379:Mice; D053769:Nanocapsules / Q000008:administration & dosage* / Q000737:chemistry / Q000648:ultrastructure; D009374:Neoplasms, Experimental / Q000000981:diagnostic imaging* / Q000473:pathology / Q000628:therapy*; D010789:Phototherapy / Q000379:methods; D000068936:Theranostic Nanomedicine / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D003692:Delayed-Action Preparations; D004343:Drug Implants; D007287:Inorganic Chemicals; D053769:Nanocapsules
keywords: Degradable; Magnetic resonance imaging; Manganese; Nanotoxicity; Photothermal therapy