title: Template-Free Synthesis of Hollow/Porous Organosilica-Fe3O4Hybrid Nanocapsules toward Magnetic Resonance Imaging-Guided High-Intensity Focused Ultrasound Therapy.
abstract: Entirely differing from the common templating-based multistep strategy for fabricating multifunctional hollow mesoporous silica nanoparticles (HMSN), a facile and template-free synthetic strategy has been established to construct a unique hollow/mesoporous organosilica nanocapsule (OSNC) concurrently encapsulating both isopentyl acetate (PeA) liquid and superparamagnetic iron oxides inside (denoted as PeA@OSNC). This novel material exhibits ultrasmall and uniform particle size (∼82 nm), high surface area (∼534 m2·g-1), and excellent colloidal stability in aqueous solution. The oil-phase PeA with relatively low boiling point (142 °C) and high volatility not only plays a crucial role in formation of a large hollow cavity from the viewpoint of structural design but also enables the PeA@OSNC to act as an efficient enhancement agent in high-intensity focused ultrasound (HIFU) therapy. Moreover, the unique satellite-like distribution of Fe3O4nanoparticles (NP) on the organosilica shell offered excellent magnetic resonance imaging (MRI) contrast capability of PeA@OSNC in vitro and in vivo. More importantly, such a novel theranostic agent has favorable biosafety, which is very promising for future clinical application in MRI-guided HIFU therapy.
authors: State Key Laboratory of High Performance Ceramic and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences ,1295 Dingxi Road, Shanghai 200050, People's Republic of China.
authors: Ming
authors: M
authors: Ma
authors: Paul C. Lauterbur Research Center for Biomedical Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences , 1068 Xueyuan Avenue, Shenzhen 518055, People's Republic of China.
authors: Fei
authors: F
authors: Yan
authors: Department of Ultrasound in Medicine, Shanghai Tenth People's Hospital, Tongji University School of Medicine , 301 Yanchangzhong Road, Shanghai 200072, People's Republic of China.
authors: Minghua
authors: M
authors: Yao
authors: Paul C. Lauterbur Research Center for Biomedical Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences , 1068 Xueyuan Avenue, Shenzhen 518055, People's Republic of China.
authors: Zijun
authors: Z
authors: Wei
authors: Paul C. Lauterbur Research Center for Biomedical Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences , 1068 Xueyuan Avenue, Shenzhen 518055, People's Republic of China.
authors: Dongliang
authors: D
authors: Zhou
authors: State Key Laboratory of High Performance Ceramic and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences ,1295 Dingxi Road, Shanghai 200050, People's Republic of China.
authors: Heliang
authors: H
authors: Yao
authors: Paul C. Lauterbur Research Center for Biomedical Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences , 1068 Xueyuan Avenue, Shenzhen 518055, People's Republic of China.
authors: Hairong
authors: H
authors: Zheng
authors: State Key Laboratory of High Performance Ceramic and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences ,1295 Dingxi Road, Shanghai 200050, People's Republic of China.
authors: Hangrong
authors: H
authors: Chen
authors: State Key Laboratory of High Performance Ceramic and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences ,1295 Dingxi Road, Shanghai 200050, People's Republic of China.
authors: Jianlin
authors: J
authors: Shi
mesh_terms: D000074059:Extracorporeal Shockwave Therapy; D005296:Ferrous Compounds; D057086:High-Intensity Focused Ultrasound Ablation; D006801:Humans; D008279:Magnetic Resonance Imaging; D053769:Nanocapsules; D016062:Porosity
chemical_list: D005296:Ferrous Compounds; D053769:Nanocapsules; C034236:ferrous oxide
keywords: HIFU; contrast agent; hollow mesoporous nanoparticle; organosilica; theranostic