title: Long-Term Effects of Neonatal Pain and Stress on Reactivity of the Nociceptive System.
abstract: The influence of inflammatory pain and/or weaning stress at different terms of neonatal development on functional activity of the nociceptive system during adulthood was studied in rats. Repeated stress in 1-2-day-old rat pups (a premature baby model) enhanced pain sensitivity to peripheral inflammation in both males and females. Repeated inflammatory pain experienced by male pups aged 1-2 or 7-8 days (models of preterm and full-term baby), even in presence of mother, enhanced pain behavior under conditions of repeated inflammatory pain in adulthood. Pain sensitivity in adult animals before (hot plate test) and after formation of the inflammatory focus (formalin test) depended on the age when the animals were subjected to the injury, type of exposure, and on animal sex. The priority data obtained by us will help to understand the mechanisms of long-term effects of early injuries and are important for pediatricians and neonatologists.
authors: Laboratory of Ontogenesis of the Nervous System, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia. irinabutkevich@yandex.ru.
authors: I P
authors: IP
authors: Butkevich
authors: Laboratory of Ontogenesis of the Nervous System, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia.
authors: V A
authors: VA
authors: Mikhailenko
mesh_terms: D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D001522:Behavior, Animal; D005260:Female; D005557:Formaldehyde / Q000008:administration & dosage*; D007249:Inflammation; D008297:Male; D059225:Nociception / Q000187:drug effects*; D010146:Pain / Q000139:chemically induced / Q000503:physiopathology* / Q000523:psychology; D010147:Pain Measurement; D017288:Pain Threshold / Q000523:psychology; D051381:Rats; D017208:Rats, Wistar; D012737:Sex Factors; D013315:Stress, Psychological / Q000503:physiopathology*; D014886:Weaning
chemical_list: D005557:Formaldehyde
keywords: adult rats; neonatal period; repeated pain; sexual dimorphism; stress