title: Immunohistochemical expression of MDR1-Pgp 170 in canine cutaneous and oral melanomas: pattern of expression and association with tumour location and phenotype.
abstract: Canine melanoma (CMM) more commonly affects the oral mucosa and the cutis. CMM shares several features with human melanomas (HMM), included resistance to a broad variety of antineoplastic chemotherapy agents. P-glycoprotein 1 (Pgp) expression is a well-recognized feature of multi-drug resistance and the purpose of this study was to investigate its expression in treatment naïve CMM. We also investigated Pgp association with tumour location and histological features. Histology records of CMM were retrieved, including patients from 2012-2014. Twenty-five cases of CMM were included in this study. Results revealed that Pgp is expressed in CMM and oral tumours were more likely to have a membranous Pgp expression (100%) than cutaneous tumours (66.6%) (P = 0.010). Cytoplasmic and nuclear Pgp expression could also be identified. Results of this study bring useful data that help in understanding one of the possible mechanisms responsible of intrinsic chemotherapy resistance in canine CMM.
authors: Small Animal Teaching Hospital, Institute of Veterinary Sciences, University of Liverpool, Neston, UK.
authors: R
authors: R
authors: Finotello
authors: Section of Veterinary Pathology, Institute of Veterinary Sciences, University of Liverpool, Neston, UK.
authors: J M
authors: JM
authors: Monné Rodriguez
authors: Laboratorio de Diagnóstico Histopatológico Histovet, Avda Països Catalans, Barcelona, Spain.
authors: M
authors: M
authors: Vilafranca
authors: Laboratorio de Diagnóstico Histopatológico Histovet, Avda Països Catalans, Barcelona, Spain.
authors: J
authors: J
authors: Altimira
authors: Laboratorio de Diagnóstico Histopatológico Histovet, Avda Països Catalans, Barcelona, Spain.
authors: G A
authors: GA
authors: Ramirez
authors: Institute of Veterinary Sciences, University of Liverpool, Neston, UK.
authors: A
authors: A
authors: Haines
authors: Section of Veterinary Pathology, Institute of Veterinary Sciences, University of Liverpool, Neston, UK.
authors: L
authors: L
authors: Ressel
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000378:metabolism*; D000818:Animals; D004283:Dog Diseases / Q000378:metabolism* / Q000473:pathology; D004285:Dogs; D005260:Female; D008297:Male; D008545:Melanoma / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D009062:Mouth Neoplasms / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D012878:Skin Neoplasms / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1
keywords: MDR1; Pgp170; canine cutaneous melanoma; canine oral melanoma