title: Interaction Between Orexin-A and Sleep Quality in Females in Extreme Weight Conditions.
abstract: The current study examined the relationship between plasma orexin-A and sleep in obesity. Concentrations of orexin-A and sleep were evaluated in 26 obese, 40 morbid obese and 32 healthy-weight participants. The sleep monitor Actiwatch AW7 and the Pittsburgh Sleep Quality Index were used to evaluate sleep. The Symptom Checklist-90-Revised was administered to assess symptoms of psychopathology. A higher weight status was associated with elevated orexin-A levels (p = .050), greater depression, anxiety and somatization symptoms (all: p < .001), and impoverished self-reported sleep quality (p < .001). A quadratic trend was found in objective sleep time, being longest in the obese group (p = .031). Structural equation modelling showed plasma orexin-A to be related to poor total sleep quality, which in turn was associated with elevated body mass index. Our data confirm an interaction between elevated plasma orexin-A concentrations and poor sleep that contributes to fluctuations in body mass index. Copyright © 2016 John Wiley & Sons, Ltd and Eating Disorders Association.
authors: Department of Psychiatry, University Hospital of Bellvitge-IDIBELL, Barcelona, Spain.|CIBER Fisiopatología Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain.
authors: Sarah
authors: S
authors: Sauchelli
authors: Department of Psychiatry, University Hospital of Bellvitge-IDIBELL, Barcelona, Spain.|CIBER Fisiopatología Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain.|Department of Clinical Sciences, School of Medicine, University of Barcelona, Barcelona, Spain.
authors: Susana
authors: S
authors: Jiménez-Murcia
authors: CIBER Fisiopatología Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain.|Unidad de Gestión Clínica de Endocrinología y Nutrición, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Clínico Virgen de la Victoria, Malaga, Spain.
authors: Jose C
authors: JC
authors: Fernández-García
authors: CIBER Fisiopatología Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain.|Unidad de Gestión Clínica de Endocrinología y Nutrición, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Clínico Virgen de la Victoria, Malaga, Spain.
authors: Lourdes
authors: L
authors: Garrido-Sánchez
authors: CIBER Fisiopatología Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain.|Unidad de Gestión Clínica de Endocrinología y Nutrición, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Clínico Virgen de la Victoria, Malaga, Spain.
authors: Francisco J
authors: FJ
authors: Tinahones
authors: CIBER Fisiopatología Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain.|Department of Medicine, Endocrinology Division, Santiago de Compostela University, Complejo Hospitalario Universitario, Santiago de Compostela, Spain.
authors: Felipe F
authors: FF
authors: Casanueva
authors: CIBER Fisiopatología Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain.|Department of Psychological, Personality, Evaluation and Treatment, University of Valencia, Valencia, Spain.
authors: Rosa M
authors: RM
authors: Baños
authors: CIBER Fisiopatología Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain.|Department of Basic Psychology, Clinic and Psychobiology, University Jaume I, Castelló, Spain.
authors: Cristina
authors: C
authors: Botella
authors: CIBER Fisiopatología Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain.|Department of Medicine, Endocrinology Division, Santiago de Compostela University, Complejo Hospitalario Universitario, Santiago de Compostela, Spain.
authors: Ana B
authors: AB
authors: Crujeiras
authors: CIBER Fisiopatología Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain.|Integrated Pharmacology and Systems Neurosciences Research Group, Neuroscience Research Program Organization IMIM, Hospital del Mar Medical Research Institute, Barcelona, Spain.|Department of Health and Experimental Sciences, Universitat Pompeu Fabra, Barcelona, Spain.
authors: Rafael
authors: R
authors: de la Torre
authors: CIBER Fisiopatología Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain.|Department of Diabetes, Endocrinology and Nutrition, Institu d'Investigació, Biomèdica de Girona (IdIBGi), Hospital Dr Josep Trueta, Girona, Spain.
authors: Jose M
authors: JM
authors: Fernández-Real
authors: CIBER Fisiopatología Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain.|Metabolic Research Laboratory, Clínica Universidad de Navarra, University of Navarra-IdiSNA, Pamplona, Spain.
authors: Gema
authors: G
authors: Frühbeck
authors: CIBER Fisiopatología Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain.|Department of Psychobiology and Methodology, Autonomous University of Barcelona, Barcelona, Spain.
authors: Roser
authors: R
authors: Granero
authors: CIBER Fisiopatología Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain.|Department of Diabetes, Endocrinology and Nutrition, Institu d'Investigació, Biomèdica de Girona (IdIBGi), Hospital Dr Josep Trueta, Girona, Spain.
authors: Francisco J
authors: FJ
authors: Ortega
authors: CIBER Fisiopatología Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain.|Metabolic Research Laboratory, Clínica Universidad de Navarra, University of Navarra-IdiSNA, Pamplona, Spain.
authors: Amaia
authors: A
authors: Rodríguez
authors: Department of Psychosomatic Medicine, University of Tübingen, Tübingen, Germany.
authors: Stephan
authors: S
authors: Zipfel
authors: Department of Psychosomatic Medicine, University of Tübingen, Tübingen, Germany.
authors: Katrin E
authors: KE
authors: Giel
authors: Department of Psychiatry, University Hospital of Bellvitge-IDIBELL, Barcelona, Spain.|Department of Clinical Sciences, School of Medicine, University of Barcelona, Barcelona, Spain.|CIBER Salud Mental (CIBERSAM), ISCIII, Barcelona, Spain.
authors: Jose M
authors: JM
authors: Menchón
authors: Department of Psychiatry, University Hospital of Bellvitge-IDIBELL, Barcelona, Spain. ffernandez@bellvitgehospital.cat.|CIBER Fisiopatología Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain. ffernandez@bellvitgehospital.cat.|Department of Clinical Sciences, School of Medicine, University of Barcelona, Barcelona, Spain. ffernandez@bellvitgehospital.cat.
authors: Fernando
authors: F
authors: Fernández-Aranda
mesh_terms: D000328:Adult; D001007:Anxiety / Q000097:blood / Q000523:psychology; D015992:Body Mass Index; D001835:Body Weight; D016022:Case-Control Studies; D003863:Depression / Q000097:blood / Q000523:psychology; D001068:Feeding and Eating Disorders; D005260:Female; D006801:Humans; D008297:Male; D009765:Obesity / Q000097:blood* / Q000523:psychology; D009767:Obesity, Morbid / Q000097:blood* / Q000523:psychology; D000068797:Orexins / Q000097:blood*; D050177:Overweight; D012890:Sleep / Q000502:physiology*; D012893:Sleep Wake Disorders / Q000097:blood* / Q000503:physiopathology; D055815:Young Adult
chemical_list: D000068797:Orexins
keywords: body mass index; obesity; orexin; sleep