title: Three new phenylpropanoids from Lavandula angustifolia and their bioactivities.
abstract: Three new phenylpropanoids, 3-(3,4-dimethoxy-5-methylphenyl)-3-oxopropyl acetate (1), 3-hydroxy-1-(3,4-dimethoxy-5-methylphenyl)propan-1-one (2), and 3-hydroxy-1-(4-methylbenzo[d][1,3]dioxol-6-yl) propan-1-one (3), together with three known phenylpropanoids (4-6) were isolated from the whole plant of Lavandula angustifolia. Their structures were determined by means of HRESIMS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1-6 were tested for their anti-tobacoo mosaic virus (TMV) activities and cytotoxicity activities. The results revealed that compounds 1-3 showed high anti-TMV activity with inhibition rate of 35.2, 38.4 and 33.9%. These rates are higher than that of positive control. The other compounds also showed potential anti-TMV activities with inhibition rates in the range of 26.8-28.9%, respectively. Compounds 1-6 also showed weak inhibitory activities against some tested human tumour cell lines with IC50 values in the range of 3.8-8.8 μM.
authors: a Key Laboratory of Tobacco Chemistry of Yunnan Province , China Tobacco Yunnan Industrial Co., Ltd , Kunming , P.R. China.
authors: Shiyun
authors: S
authors: Tang
authors: a Key Laboratory of Tobacco Chemistry of Yunnan Province , China Tobacco Yunnan Industrial Co., Ltd , Kunming , P.R. China.|b Yunnan Key Laboratory of Pharmacology for Nature Products , School of Pharmaceutical Science , Kunming , P.R. China.
authors: Jianlian
authors: J
authors: Shi
authors: a Key Laboratory of Tobacco Chemistry of Yunnan Province , China Tobacco Yunnan Industrial Co., Ltd , Kunming , P.R. China.
authors: Chunbo
authors: C
authors: Liu
authors: a Key Laboratory of Tobacco Chemistry of Yunnan Province , China Tobacco Yunnan Industrial Co., Ltd , Kunming , P.R. China.|c College of Chemical Engineering , Kunming University of Science and Technology , Kunming , P.R. China.
authors: Rui
authors: R
authors: Jiang
authors: a Key Laboratory of Tobacco Chemistry of Yunnan Province , China Tobacco Yunnan Industrial Co., Ltd , Kunming , P.R. China.
authors: Wei
authors: W
authors: Zhao
authors: a Key Laboratory of Tobacco Chemistry of Yunnan Province , China Tobacco Yunnan Industrial Co., Ltd , Kunming , P.R. China.
authors: Xin
authors: X
authors: Liu
authors: a Key Laboratory of Tobacco Chemistry of Yunnan Province , China Tobacco Yunnan Industrial Co., Ltd , Kunming , P.R. China.
authors: Nengjun
authors: N
authors: Xiang
authors: a Key Laboratory of Tobacco Chemistry of Yunnan Province , China Tobacco Yunnan Industrial Co., Ltd , Kunming , P.R. China.
authors: Yongkuan
authors: Y
authors: Chen
authors: a Key Laboratory of Tobacco Chemistry of Yunnan Province , China Tobacco Yunnan Industrial Co., Ltd , Kunming , P.R. China.
authors: Qinpeng
authors: Q
authors: Shen
authors: a Key Laboratory of Tobacco Chemistry of Yunnan Province , China Tobacco Yunnan Industrial Co., Ltd , Kunming , P.R. China.
authors: Mingming
authors: M
authors: Miao
authors: a Key Laboratory of Tobacco Chemistry of Yunnan Province , China Tobacco Yunnan Industrial Co., Ltd , Kunming , P.R. China.
authors: Zhihua
authors: Z
authors: Liu
authors: a Key Laboratory of Tobacco Chemistry of Yunnan Province , China Tobacco Yunnan Industrial Co., Ltd , Kunming , P.R. China.
authors: Guangyu
authors: G
authors: Yang
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D000998:Antiviral Agents / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D006801:Humans; D027523:Lavandula / Q000737:chemistry*; D010666:Phenylpropionates / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014027:Tobacco Mosaic Virus / Q000187:drug effects
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D000998:Antiviral Agents; D010666:Phenylpropionates
keywords: Lavandula angustifolia; anti-tobacoo mosaic virus activities; cytotoxicity activities; phenylpropanoids