title: Nuclear Overhauser Enhancement-Mediated Magnetization Transfer Imaging in Glioma with Different Progression at 7 T.
abstract: Glioma is a malignant neoplasm affecting the central nervous system. The conventional approaches to diagnosis, such as T1-weighted imaging (T1WI), T2-weighted imaging (T2WI), and contrast-enhanced T1WI, give an oversimplified representation of anatomic structures. Nuclear Overhauser enhancement (NOE) imaging is a special form of magnetization transfer (MT) that provides a new way to detect small solute pools through indirect measurement of attenuated water signals, and makes it possible to probe semisolid macromolecular protons. In this study, we investigated the correlation between the effect of NOE-mediated imaging and progression of glioma in a rat tumor model. We found that the NOE signal decreased in tumor region, and signal of tumor center and peritumoral normal tissue markedly decreased with growth of the glioma. At the same time, NOE signal in contralateral normal tissue dropped relatively late (at about day 16-20 after implanting the glioma cells). NOE imaging is a new contrast method that may provide helpful insights into the pathophysiology of glioma with regard to mobile proteins, lipids, and other metabolites. Further, NOE images differentiate normal brain tissue from glioma tissue at a molecular level. Our study indicates that NOE-mediated imaging is a new and promising approach for estimation of tumor progression.
authors: Department of Medical Imaging, second Affiliated Hospital, Shantou University Medical College , Shantou 515041, China.
authors: Xiangyong
authors: X
authors: Tang
authors: Department of Medical Imaging, second Affiliated Hospital, Shantou University Medical College , Shantou 515041, China.|Department of Biomedical Engineering, Faculty of Medicine, University of Alberta , Edmonton T6G 2 V2, Canada.
authors: Zhuozhi
authors: Z
authors: Dai
authors: Department of Mathematics and Statistics, Hanshan Normal University , Chaozhou 521041, China.
authors: Gang
authors: G
authors: Xiao
authors: Department of Medical Imaging, second Affiliated Hospital, Shantou University Medical College , Shantou 515041, China.
authors: Gen
authors: G
authors: Yan
authors: Department of Medical Imaging, second Affiliated Hospital, Shantou University Medical College , Shantou 515041, China.
authors: Zhiwei
authors: Z
authors: Shen
authors: The First Hospital of Changsha , Changsha, Hunan 430100, China.
authors: Tao
authors: T
authors: Zhang
authors: Department of Medical Imaging, second Affiliated Hospital, Shantou University Medical College , Shantou 515041, China.
authors: Guishan
authors: G
authors: Zhang
authors: Department of Medical Imaging, second Affiliated Hospital, Shantou University Medical College , Shantou 515041, China.
authors: Zerui
authors: Z
authors: Zhuang
authors: Department of Medical Imaging, second Affiliated Hospital, Shantou University Medical College , Shantou 515041, China.
authors: Yuanyu
authors: Y
authors: Shen
authors: Department of Medical Imaging, second Affiliated Hospital, Shantou University Medical College , Shantou 515041, China.
authors: Zhiyan
authors: Z
authors: Zhang
authors: Department of Medical Imaging, second Affiliated Hospital, Shantou University Medical College , Shantou 515041, China.
authors: Wei
authors: W
authors: Hu
authors: Department of Medical Imaging, second Affiliated Hospital, Shantou University Medical College , Shantou 515041, China.|Provincial Key Laboratory of Medical Molecular Imaging , Shantou, Guangdong 515041, China.
authors: Renhua
authors: R
authors: Wu
mesh_terms: D000465:Algorithms; D000577:Amides / Q000737:chemistry; D000818:Animals; D001932:Brain Neoplasms / Q000000981:diagnostic imaging*; D004195:Disease Models, Animal; D018450:Disease Progression; D005260:Female; D005910:Glioma / Q000000981:diagnostic imaging*; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D011522:Protons; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000577:Amides; D011522:Protons
keywords: Magnetization transfer; chemical exchange saturation transfer; glioma; nuclear Overhauser enhancement