title: Differential Regulation of Myeloid-Derived Suppressor Cells byCandidaSpecies.
abstract: Myeloid-derived suppressor cells (MDSCs) are innate immune cells characterized by their ability to suppress T-cell responses. Recently, we demonstrated that the human-pathogenic fungiCandida albicansandAspergillus fumigatusinduced a distinct subset of neutrophilic MDSCs. To dissectCandida-mediated MDSC induction in more depth, we studied the relative efficacy of different pathogenic non-albicans Candidaspecies to induce and functionally modulate neutrophilic MDSCs, includingC. glabrata, C. parapsilosis, C. dubliniensis, andC. krusei. Our data demonstrate that the extent of MDSC generation is largely dependent on theCandidaspecies with MDSCs induced byC. kruseiandC. glabratashowing a higher suppressive activity compared to MDSCs induced byC. albicans.In summary, these studies show that fungal MDSC induction is differentially regulated at the species level and differentially affects effector T-cell responses.
authors: University Children's Hospital and Interdisciplinary Center for Infectious Diseases, University of Tübingen Tübingen, Germany.
authors: Anurag
authors: A
authors: Singh
authors: University Children's Hospital and Interdisciplinary Center for Infectious Diseases, University of Tübingen Tübingen, Germany.
authors: Felipe
authors: F
authors: Lelis
authors: University Children's Hospital and Interdisciplinary Center for Infectious Diseases, University of Tübingen Tübingen, Germany.
authors: Stefanie
authors: S
authors: Braig
authors: University Children's Hospital and Interdisciplinary Center for Infectious Diseases, University of Tübingen Tübingen, Germany.
authors: Iris
authors: I
authors: Schäfer
authors: University Children's Hospital and Interdisciplinary Center for Infectious Diseases, University of Tübingen Tübingen, Germany.
authors: Dominik
authors: D
authors: Hartl
authors: University Children's Hospital and Interdisciplinary Center for Infectious Diseases, University of TübingenTübingen, Germany; Department of Pediatrics, Kinderklinik München Schwabing, StKM GmbH und Klinikum rechts der Isar, Technische Universität MünchenMunich, Germany.
authors: Nikolaus
authors: N
authors: Rieber
keywords: Candida; Dectin-1; Dectin-2; MDSCs; T-cell suppression; anti-fungal immunity; myeloid-derived suppressor cells