title: Neonatal isolation augments social dominance by altering actin dynamics in the medial prefrontal cortex.
abstract: Social separation early in life can lead to the development of impaired interpersonal relationships and profound social disorders. However, the underlying cellular and molecular mechanisms involved are largely unknown. Here, we found that isolation of neonatal rats induced glucocorticoid-dependent social dominance over nonisolated control rats in juveniles from the same litter. Furthermore, neonatal isolation inactivated the actin-depolymerizing factor (ADF)/cofilin in the juvenile medial prefrontal cortex (mPFC). Isolation-induced inactivation of ADF/cofilin increased stable actin fractions at dendritic spines in the juvenile mPFC, decreasing glutamate synaptic AMPA receptors. Expression of constitutively active ADF/cofilin in the mPFC rescued the effect of isolation on social dominance. Thus, neonatal isolation affects spines in the mPFC by reducing actin dynamics, leading to altered social behavior later in life.
authors: Department of Physiology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.
authors: Hirobumi
authors: H
authors: Tada
authors: Department of Physiology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.
authors: Tomoyuki
authors: T
authors: Miyazaki
authors: Department of Physiology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.|Precursory Research for Embryonic Science and Technology, Japan Science and Technology Agency, Saitama 332-0012, Japan.
authors: Kiwamu
authors: K
authors: Takemoto
authors: Laboratory of Psychology, Jichi Medical University, Tochigi 329-0498, Japan.
authors: Kenkichi
authors: K
authors: Takase
authors: Department of Physiology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.
authors: Susumu
authors: S
authors: Jitsuki
authors: Department of Physiology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.
authors: Waki
authors: W
authors: Nakajima
authors: Department of Physiology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.
authors: Mayu
authors: M
authors: Koide
authors: Department of Physiology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.
authors: Naoko
authors: N
authors: Yamamoto
authors: Department of Physiology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.
authors: Kasane
authors: K
authors: Komiya
authors: Department of Physiology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.
authors: Kumiko
authors: K
authors: Suyama
authors: Department of Physiology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.
authors: Akane
authors: A
authors: Sano
authors: Department of Integrative Aging Neuroscience, National Center for Geriatrics and Gerontology, Aichi 474-8511, Japan.
authors: Akiko
authors: A
authors: Taguchi
authors: Department of Physiology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan; takahast@yokohama-cu.ac.jp.
authors: Takuya
authors: T
authors: Takahashi
keywords: AMPA receptor trafficking; actin dynamics; medial prefrontal cortex; social dominance; social isolation stress