title: [Gender differences in lipocalin 2 plasmatic levels are correlated with age and the triglyceride/high-density lipoprotein ratio in healthy individuals].
abstract: BACKGROUND
  The increment of lipocalin 2, also called neutrophil gelatinase-associated lipocalin, plasmatic levels is associated with cardiometabolic and nefrologic alterations. Nonetheless, there is much controversy about lipocalin 2 plasmatic concentrations among healthy individuals.
  
  
  OBJECTIVE
  The aim of this study was to quantify lipocalin 2 in plasma of healthy men and women and to assess a possible correlation with cardiometabolic risk factors.
  
  
  METHODS
  Fifty-three subjects (24 men and 29 women) were included. By means of an ELISA, a higher concentration of lipocalin 2 was observed in men than in women (91 ± 9 vs. 57 ± 7 ng/ml). Such difference was statistically significant (p < 0.0001).
  
  
  RESULTS
  Lipocalin 2 levels were significantly correlated with body mass index, homeostasis model assessment index-insulin resistance index, triglycerides, high-density lipoprotein, and age.
  
  
  CONCLUSIONS
  Lipocalin 2 plasmatic concentrations present a gender-specific profile in healthy subjects and its circulating levels appear to be age-dependent and associated with several cardiometabolic risk factors, including the triglycerides/high-density lipoprotein cholesterol ratio, which has proven to be a reliable marker for cardiometabolic risk among the global population.
authors: Research Unit in Metabolic Diseases, Centro Médico Nacional Siglo XXI, IMSS, Mexico City, Mexico.
authors: Elsa
authors: E
authors: De la Chesnaye
authors: Research Unit in Endocrine Diseases, Centro Médico Nacional Siglo XXI, IMSS, Mexico City, Mexico.
authors: Leticia
authors: L
authors: Manuel-Apolinar
authors: Research Unit in Metabolic Diseases, Centro Médico Nacional Siglo XXI, IMSS, Mexico City, Mexico.
authors: Norma
authors: N
authors: Oviedo-de Anda
authors: Research Unit in Metabolic Diseases, Centro Médico Nacional Siglo XXI, IMSS, Mexico City, Mexico.
authors: María Cristina
authors: MC
authors: Revilla-Monsalve
authors: Research Unit in Metabolic Diseases, Centro Médico Nacional Siglo XXI, IMSS, Mexico City, Mexico.
authors: Sergio
authors: S
authors: Islas-Andrade
mesh_terms: D000328:Adult; D000367:Age Factors; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D008076:Cholesterol, HDL; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D000071068:Lipocalin-2 / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D065228:Non-Randomized Controlled Trials as Topic; D012307:Risk Factors; D012737:Sex Factors; D014280:Triglycerides / Q000097:blood*
chemical_list: D015415:Biomarkers; D008076:Cholesterol, HDL; D000071068:Lipocalin-2; D008075:Lipoproteins, HDL; D014280:Triglycerides