title: Effect of Alcoholic Intoxication on the Risk of Inflammatory Bowel Disease: A Nationwide Retrospective Cohort Study.
abstract: OBJECTIVE
  This study investigated whether alcoholic intoxication (AI) increases the risk of inflammatory bowel disease (IBD) by using a population-based database in Taiwan.
  
  
  METHODS
  This retrospective matched-cohort study included 57 611 inpatients with new-onset AI (AI cohort) and 230 444 randomly selected controls (non-AI cohort). Each patient was monitored for 10 years to individually identify those who were subsequently diagnosed with Crohn disease (CD) and ulcerative colitis (UC) during the follow-up period. Cox proportional hazard regression analysis was conducted to determine the risk of IBD in patients with AI compared with controls without AI.
  
  
  RESULTS
  The incidence rate of IBD during the 10-year follow-up period was 2.69 per 1 000 person-years and 0.49 per 1 000 person-years in the AI and non-AI cohorts, respectively. After adjustment for age, sex, and comorbidity, the AI cohort exhibited a 3.17-fold increased risk of IBD compared with the non-AI cohort (hazard ratio [HR] = 3.17, 95% confidence interval [CI] = 2.19-4.58). Compared with the non-AI cohort, the HRs of CD and UC were 4.40 and 2.33 for the AI cohort, respectively. After stratification for the severity of AI according to the duration of hospital stay, the adjusted HRs exhibited a significant correlation with the severity; the HRs of IBD were 1.76, 6.83, and 19.9 for patients with mild, moderate, and severe AI, respectively (p for the trend < .0001).
  
  
  CONCLUSIONS
  The risk of IBD was higher in patients with AI and increased with the length of hospital stay.
authors: Department of Emergency Medicine, China Medical University Hospital, Taichung, Taiwan.|School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan.
authors: Tai-Yi
authors: TY
authors: Hsu
authors: Department of Emergency Medicine, China Medical University Hospital, Taichung, Taiwan.|School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan.
authors: Hong-Mo
authors: HM
authors: Shih
authors: School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan.|Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan.
authors: Yu-Chiao
authors: YC
authors: Wang
authors: Department of Emergency Medicine, Chang Gung Memorial Hospital, Chiayi, Taiwan.|Department of Nursing, Chang Gung University of Science and Technology, Chiayi, Taiwan.
authors: Leng-Chieh
authors: LC
authors: Lin
authors: Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.|Department of Dermatology, National Taiwan University Hospital Yunlin Branch, Douliou, Taiwan.
authors: Guan-Yi
authors: GY
authors: He
authors: Department of Emergency Medicine, China Medical University Hospital, Taichung, Taiwan.|School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan.
authors: Chih-Yu
authors: CY
authors: Chen
authors: Graduate Institute of Clinical Medical Science and School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan.|Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan.|Department of Bioinformatics and Medical Engineering, Asia University, Taichung, Taiwan.
authors: Chia-Hung
authors: CH
authors: Kao
authors: Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung, Taiwan.
authors: Chao-Hsien
authors: CH
authors: Chen
authors: Department of Emergency Medicine, China Medical University Hospital, Taichung, Taiwan.|School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan.
authors: Wei-Kung
authors: WK
authors: Chen
authors: Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung, Taiwan.|Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan.
authors: Tse-Yen
authors: http://orcid.org/0000-0002-3165-132X
authors: TY
authors: Yang
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000435:Alcoholic Intoxication / Q000150:complications*; D005260:Female; D005500:Follow-Up Studies; D006760:Hospitalization; D006801:Humans; D015994:Incidence; D015212:Inflammatory Bowel Diseases / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D012737:Sex Factors; D013624:Taiwan / Q000453:epidemiology