title: Pathogenic characterization of Erysipelothrix rhusiopathiae Met-203 type SpaA strains from chronic and subacute swine erysipelas in Japan.
abstract: To characterize the Erysipelothrix rhusiopathiae Met-203 type surface protective antigen (Spa) A strains causing swine erysipelas in Japan, the nucleotide sequence of the hypervariable region of the spaA gene was determined in 80 E. rhusiopathiae (serotype 1a) isolates collected from pigs with chronic and subacute swine erysipelas in 14 prefectures in 2008-2014. In this study, 14 (17.5%) isolates were Met-203 type SpaA strains. We confirmed the pathogenicity of a Met-203 type SpaA strain in specific-pathogen-free pigs. In this experiment, the two challenged pigs displayed arthritis, urticaria and other clinical signs, but recovered within 10 days. Our results reveal the existence of the E. rhusiopathiae Met-203 type strains that have been causing chronic erysipelas in Japan.
authors: National Veterinary Assay Laboratory, Ministry of Agriculture, Forestry and Fisheries, 1-15-1 Tokura, Kokubunji, Tokyo 185-8511, Japan.
authors: Mariko
authors: M
authors: Uchiyama
authors: Yohko
authors: Y
authors: Shimazaki
authors: Yukari
authors: Y
authors: Isshiki
authors: Akemi
authors: A
authors: Kojima
authors: Fumiya
authors: F
authors: Hirano
authors: Kinya
authors: K
authors: Yamamoto
authors: Mayumi
authors: M
authors: Kijima
authors: Hidetaka
authors: H
authors: Nagai
mesh_terms: D000818:Animals; D000942:Antigens, Bacterial / Q000235:genetics; D002908:Chronic Disease; D004269:DNA, Bacterial / Q000032:analysis; D004888:Erysipelothrix / Q000235:genetics / Q000302:isolation & purification / Q000472:pathogenicity*; D007564:Japan; D051379:Mice; D012703:Serotyping; D013047:Specific Pathogen-Free Organisms; D013552:Swine; D013554:Swine Erysipelas / Q000453:epidemiology / Q000382:microbiology* / Q000473:pathology
chemical_list: D000942:Antigens, Bacterial; D004269:DNA, Bacterial