title: [Relationship between Bone Markers and the Progression of Multiple Myeloma].
abstract: OBJECTIVE
  To study the relationship between bone markers and the progression of multiple myeloma (MM).
  
  
  METHODS
  Retrospective analysis of 100 MM patients hospitalized in the Department of Hematology of Peking University Third Hospital between March 2012 and March 2016 was performed. The patients were divided into Group A (n=33), which consisted of patients with complete remission (CR), very good partial remission (VGPR), partial remission (PR) and stable disease (SD) and group B (n=67), which consisted of newly diagnosed patients and patients with progression of disease (PD). Serum N-MID osteocalcin (N-MID osteocalcin), procollagen I amino-terminal propeptide (PINP) and β-C-terminal telopeptide of type I collagen (β-CTx) were measured by electrochemiluminescence immunoassay (ECLIA). Multiple logistic regression was used to analyzed the correlation between bone markers and PD of MM.
  
  
  RESULTS
  PINP and β-CTx were significantly higher in group B than that in group A, mean 51.41 ng/ml vs 77.48 ng/ml (P=0.026); 0.52 ng/ml vs 1.03 ng/ml(P=0.01) respectively. There was no significant difference in N-MID level between the 2 groups (P=0.27). Multivariate analysis showed β-CTx was an independent risk factor for PD of MM.
  
  
  CONCLUSIONS
  Serum PINP and β-CTx levels are different in PD and stable stages of MM, and β-CTx can be used as an index for monitoring of PD of MM.
authors: Department of Hematology, The Third Hosital of Peking University, Beijing 100191, China.
authors: Yan
authors: Y
authors: Liu
authors: Department of Hematology, The Third Hosital of Peking University, Beijing 100191, China. E-mail: xykbysy@163.com.
authors: Xiao-Yan
authors: XY
authors: Ke
authors: Department of Hematology, The Third Hosital of Peking University, Beijing 100191, China.
authors: Lei
authors: L
authors: Tian
authors: Department of Hematology, The Third Hosital of Peking University, Beijing 100191, China.
authors: Wei
authors: W
authors: Wan
authors: Department of Hematology, The Third Hosital of Peking University, Beijing 100191, China.
authors: Fei
authors: F
authors: Dong
authors: Department of Hematology, The Third Hosital of Peking University, Beijing 100191, China.
authors: Jing
authors: J
authors: Wang
mesh_terms: D015415:Biomarkers; D024042:Collagen Type I; D018450:Disease Progression; D006801:Humans; D009101:Multiple Myeloma; D015675:Osteocalcin; D010446:Peptide Fragments; D010455:Peptides; D011347:Procollagen; D012189:Retrospective Studies
chemical_list: D015415:Biomarkers; D024042:Collagen Type I; D010446:Peptide Fragments; D010455:Peptides; D011347:Procollagen; C052929:collagen type I trimeric cross-linked peptide; D015675:Osteocalcin