title: How Much Does Inbreeding Reduce Heterozygosity? Empirical Results from Aedes aegypti.
abstract: Deriving strains of mosquitoes with reduced genetic variation is useful, if not necessary, for many genetic studies. Inbreeding is the standard way of achieving this. Full-sib inbreeding the mosquito Aedes aegypti for seven generations reduced heterozygosity to 72% of the initial heterozygosity in contrast to the expected 13%. This deviation from expectations is likely due to high frequencies of deleterious recessive alleles that, given the number of markers studied (27,674 single nucleotide polymorphisms [SNPs]), must be quite densely spread in the genome.
authors: Yale University, New Haven, Connecticut. jeffrey.powell@yale.edu.
authors: Jeffrey R
authors: JR
authors: Powell
authors: Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut.
authors: Benjamin R
authors: BR
authors: Evans
mesh_terms: D000330:Aedes / Q000235:genetics*; D000818:Animals; D014644:Genetic Variation; D007178:Inbreeding; D019656:Loss of Heterozygosity / Q000235:genetics*