title: Silymarin and Its Role in Chronic Diseases.
abstract: Silymarin is the active constituent of Silybum marianum (milk thistle) which is a C-25 containing flavonolignan. Milk thistle has a lot of traditional values, being used as a vegetable, as salad, as bitter tonic, and as galactogogue in nursing mothers and in various ailments such as liver complications, depression, dyspepsia, spleenic congestions, varicose veins, diabetes, amenorrhea, uterine hemorrhage, and menstrual problems. In this present chapter, a comprehensive attempt has been made to discuss the potential of silymarin in chronic disorders. An insight into modulation of cellular signaling by silymarin and its implication in various disorders such as liver disorders, inflammatory disorders, cancer, neurological disorders, skin diseases, and hypercholesterolemia is being provided.
authors: Pharmacology Division, Department of Pharmaceutical Sciences and Drug Research, Faculty of Medicine, Punjabi University, Patiala, 147002, Punjab, India.
authors: Neha
authors: Pharmacology Division, Department of Pharmaceutical Sciences and Drug Research, Faculty of Medicine, Punjabi University, Patiala, 147002, Punjab, India.
authors: Amteshwar S
authors: AS
authors: Jaggi
authors: Pharmacology Division, Department of Pharmaceutical Sciences and Drug Research, Faculty of Medicine, Punjabi University, Patiala, 147002, Punjab, India. nirmal_puru@rediffmail.com.
authors: Nirmal
authors: N
authors: Singh
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D002908:Chronic Disease / Q000188:drug therapy*; D004195:Disease Models, Animal; D055808:Drug Discovery / Q000379:methods*; D006801:Humans; D000960:Hypolipidemic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D020944:Silybum marianum / Q000737:chemistry*; D015394:Molecular Structure; D008517:Phytotherapy; D010946:Plants, Medicinal; D015398:Signal Transduction / Q000187:drug effects; D012838:Silymarin / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D013329:Structure-Activity Relationship
chemical_list: D000893:Anti-Inflammatory Agents; D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants; D000960:Hypolipidemic Agents; D012838:Silymarin
keywords: Cancer; Hepatitis; Immunomodulation; Isosilybin; Oxidative stress; Silybin; Silybum marianum; Silymarin