title: Use of Intra-Articular Amphotericin B in the Treatment of Candida parasilosis and albicans in Prosthetic Joint Infections (PJI): A Novel Approach to this Difficult Problem.
abstract: BACKGROUND
  Use of intra-articular antibiotics for the treatment of arthroplasty infections has gained some interest over the last few years.
  
  
  OBJECTIVE
  Some data exists on its use with bacterial arthroplasty infections.
  
  
  METHODS
  We used intra-articular amphotericin B in an attempt to cure these joint infections and perform a one stage revision.
  
  
  RESULTS
  Two patients were treated with intra-articular amphotericin B for 6 weeks followed by suppressive fluconazole for 4 months. Intra-articular joint fluid was cultured during this process for re-growth of fungus.
  
  
  CONCLUSIONS
  Both patients were treated successfully with the method with follow up showing no evidence of recurrence. IA administration of amphotericin B may be an alternative treatment in these patients.
authors: New Mexico State University, El Paso Texas. United States.
authors: Leigh G
authors: LG
authors: Cooper
authors: Providence Medical Center, El Paso, Texas. United States.
authors: Jacob
authors: J
authors: Heydemann
authors: Providence Medical Center, El Paso, Texas. United States.
authors: Gregory
authors: G
authors: Misenhimer
authors: 1205 N. Oregon El Paso, TX 79902, Texas. United States.
authors: Suresh
authors: S
authors: Antony
mesh_terms: D000368:Aged; D000666:Amphotericin B / Q000008:administration & dosage* / Q000627:therapeutic use; D000935:Antifungal Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D019645:Arthroplasty, Replacement, Knee; D002175:Candida / Q000187:drug effects* / Q000254:growth & development / Q000302:isolation & purification; D002177:Candidiasis / Q000188:drug therapy* / Q000382:microbiology; D003141:Communicable Diseases / Q000188:drug therapy / Q000382:microbiology; D005260:Female; D015725:Fluconazole / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D007270:Injections, Intra-Articular; D007720:Knee Prosthesis / Q000382:microbiology*; D008297:Male; D016459:Prosthesis-Related Infections / Q000188:drug therapy* / Q000382:microbiology; D013582:Synovial Fluid / Q000382:microbiology; D017211:Treatment Failure
chemical_list: D000935:Antifungal Agents; D000666:Amphotericin B; D015725:Fluconazole
keywords: Hickman
  catheter; Intra-articular; amphotericin B; candida; prosthetic joint infection; treatment failure