title: Advances in venomics.
abstract: The term "venomics" was coined to describe the global study of venom and venom glands, targeting comprehensive characterization of the whole toxin profile of a venomous animal by means of proteomics, transcriptomics, genomics and bioinformatics studies. This integrative approach is supported by the rapid evolution of protein, RNA and DNA sequencing techniques, as well as databases, knowledge-bases and biocomputing algorithms. The aim of this review is to illustrate advances in the field of venomics during the last decade, addressing each step of the procedure, from sample collection to data treatment. A special focus is made on new perspectives for a better understanding of the venomous function and for fostering the discovery of new venom-derived drug candidates.
authors: Atheris SA, Chemin d'Alcire 1, CH-1228 Plan-les-Ouates, Geneva, Switzerland. contact@atheris.com and School of Pharmaceutical Sciences, EPGL, University of Geneva, University of Lausanne, CMU, 1, Rue Michel Servet, CH-1211 Geneva 4, Switzerland.
authors: Vera
authors: V
authors: Oldrati
authors: Atheris SA, Chemin d'Alcire 1, CH-1228 Plan-les-Ouates, Geneva, Switzerland. contact@atheris.com.
authors: Miriam
authors: M
authors: Arrell
authors: Alphabiotoxine Laboratory Sprl, Montroeul-au-Bois B-7911, Belgium.
authors: Aude
authors: A
authors: Violette
authors: Atheris SA, Chemin d'Alcire 1, CH-1228 Plan-les-Ouates, Geneva, Switzerland. contact@atheris.com.
authors: Frédéric
authors: F
authors: Perret
authors: Atheris SA, Chemin d'Alcire 1, CH-1228 Plan-les-Ouates, Geneva, Switzerland. contact@atheris.com.
authors: Xavier
authors: X
authors: Sprüngli
authors: School of Pharmaceutical Sciences, EPGL, University of Geneva, University of Lausanne, CMU, 1, Rue Michel Servet, CH-1211 Geneva 4, Switzerland.
authors: Jean-Luc
authors: JL
authors: Wolfender
authors: Atheris SA, Chemin d'Alcire 1, CH-1228 Plan-les-Ouates, Geneva, Switzerland. contact@atheris.com.
authors: Reto
authors: R
authors: Stöcklin
mesh_terms: D000818:Animals; D019295:Computational Biology / Q000379:methods; D016678:Genome; D023281:Genomics / Q000379:methods; D059014:High-Throughput Nucleotide Sequencing; D040901:Proteomics / Q000379:methods; D013048:Specimen Handling; D059467:Transcriptome; D014688:Venoms / Q000235:genetics* / Q000302:isolation & purification / Q000378:metabolism* / Q000627:therapeutic use
chemical_list: D014688:Venoms