title: N-Methylanilines as Simple and Efficient Promoters for Radical-Type Cross-Coupling Reactions of Aryl Iodides.
abstract: Activation of the carbon-halogen bonds in aryl halides is a key step in transition-metal-free cross-coupling reactions. In this paper, a new and efficient radical initiation system for the activation of iodoarenes to produce aryl radicals was discovered, which employs the combination of N-methylanilines and tBuOK. This radical initiation system is robust and versatile, enabling various types of aryl-radical-related reactions.
authors: Center of Basic Molecular Science (CBMS), Department of Chemistry, Tsinghua University, Beijing, 100084, P.R. China.
authors: Huan
authors: H
authors: Yang
authors: Center of Basic Molecular Science (CBMS), Department of Chemistry, Tsinghua University, Beijing, 100084, P.R. China.
authors: Li
authors: L
authors: Zhang
authors: Center of Basic Molecular Science (CBMS), Department of Chemistry, Tsinghua University, Beijing, 100084, P.R. China.
authors: Lei
authors: 0000-0002-8465-1358
authors: L
authors: Jiao
keywords: N-methylaniline; cross-coupling; electron donors; homolytic aromatic substitution; synthetic methods