title: Immune Responses to Invasive Group B Streptococcal Disease in Adults.
abstract: Immunization of nonpregnant adults could help prevent invasive group B Streptococcus (GBS) infections, but adult immune responses have not been investigated. We defined capsular polysaccharide (CPS) and pilus island (PI) surface antigen distribution and expression and immune responses to GBS infection in nonpregnant adults. Prospective surveillance from 7 hospitals in Houston, Texas, USA, identified 102 adults with GBS bacteremia; 43% had skin/soft tissue infection, 16% bacteremia without focus, and 12% osteomyelitis. CPS-specific IgG was determined by ELISA and pilus-specific IgG by multiplex immunoassay. CPS types were Ia (24.5%), Ib (12.7%), II (9.8%), III (16.7%), IV (13.7%), and V (12.7%); 9.8% were nontypeable by serologic methods. Pili, expressed by 89%, were most often PI-2a. CPS and pilus-specific IgG increased during convalescence among patients with strains expressing CPS or PI. All GBS expressed CPS or PI; 79% expressed both. Increased antibodies to CPS and PI during recovery suggests that GBS bacteremia in adults is potentially vaccine preventable.
authors: Morven S
authors: MS
authors: Edwards
authors: Marcia A
authors: MA
authors: Rench
authors: C Daniela
authors: CD
authors: Rinaudo
authors: Monica
authors: M
authors: Fabbrini
authors: Giovanna
authors: G
authors: Tuscano
authors: Giada
authors: G
authors: Buffi
authors: Erika
authors: E
authors: Bartolini
authors: Stefano
authors: S
authors: Bonacci
authors: Carol J
authors: CJ
authors: Baker
authors: Immaculada
authors: I
authors: Margarit
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000907:Antibodies, Bacterial / Q000097:blood / Q000276:immunology; D000918:Antibody Specificity / Q000276:immunology; D016470:Bacteremia; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology; D008297:Male; D008875:Middle Aged; D058889:Molecular Typing; D011135:Polysaccharides, Bacterial / Q000276:immunology; D012703:Serotyping; D013290:Streptococcal Infections / Q000175:diagnosis / Q000276:immunology* / Q000382:microbiology*; D013292:Streptococcus agalactiae / Q000145:classification / Q000235:genetics / Q000276:immunology* / Q000302:isolation & purification
chemical_list: D000907:Antibodies, Bacterial; D007074:Immunoglobulin G; D011135:Polysaccharides, Bacterial