title: Two cases of seborrheic keratosis with basal clear cells.
abstract: Seborrheic keratosis with basal clear cells (SKBCC) is an extremely rare histopathological variant of seborrheic keratosis that has histological similarities to melanoma in situ. We herein report two cases of SKBCC and provide the first description of the dermoscopic features of this condition, in addition to the histopathological findings. Both of the two lesions showed typical histological architectures of seborrheic keratosis with rows or focal clusters of monomorphic clear cells with abundant pale cytoplasm and small round nucleus in the basal layer. Immunohistochemical examination revealed that most clear cells were positive for high molecular weight cytokeratin (34βE12) in a peripheral pattern but were negative tor Melan-A. Dermoscopy revealed typical features of ordinary seborrheic keratosis, while unfortunately did not reflect the presence of basal clear cells.
authors: Sapporo Institute for Dermatopathology, Sapporo, Japan.
authors: Takashi
authors: T
authors: Anan
authors: Sapporo Institute for Dermatopathology, Sapporo, Japan.
authors: Takaya
authors: T
authors: Fukumoto
authors: Sapporo Institute for Dermatopathology, Sapporo, Japan.
authors: Tetsunori
authors: T
authors: Kimura
mesh_terms: D000368:Aged; D046169:Dermoscopy; D005260:Female; D006801:Humans; D017492:Keratosis, Seborrheic / Q000175:diagnosis / Q000473:pathology*; D008297:Male
keywords: 34βE12; Melan-A; dermoscopy; histopathology; seborrheic keratosis with basal clear cells