title: In-situ synthesis of magnetic iron-oxide nanoparticle-nanofibre composites using electrospinning.
abstract: We demonstrate a facile, one-step process to form polymer scaffolds composed of magnetic iron oxide nanoparticles (MNPs) contained within electrospun nano- and micro-fibres of two biocompatible polymers, Poly(ethylene oxide) (PEO) and Poly(vinyl pyrrolidone) (PVP). This was achieved with both needle and free-surface electrospinning systems demonstrating the scalability of the composite fibre manufacture; a 228 fold increase in fibre fabrication was observed for the free-surface system. In all cases the nanoparticle-nanofibre composite scaffolds displayed morphological properties as good as or better than those previously described and fabricated using complex multi-stage techniques. Fibres produced had an average diameter (Needle-spun: 125±18nm (PEO) and 1.58±0.28μm (PVP); Free-surface electrospun: 155±31nm (PEO)) similar to that reported previously, were smooth with no bead defects. Nanoparticle-nanofibre composites were characterised using scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX), dynamic light scattering (DLS) (Nanoparticle average diameter ranging from 8±3nm to 27±5nm), XRD (Phase of iron oxide nanoparticles identified as magnetite) and nuclear magnetic resonance relaxation measurements (NMR) (T1/T2: 32.44 for PEO fibres containing MNPs) were used to verify the magnetic behaviour of MNPs. This study represents a significant step forward for production rates of magnetic nanoparticle-nanofibre composite scaffolds by the electrospinning technique.
authors: Biomaterials, Biofouling and Biofilms Engineering Laboratory (B(3)EL), Systems and Process Engineering Centre, College of Engineering, Swansea University, Fabian Way, Swansea SA1 8EN, UK; Systems and Process Engineering Centre, College of Engineering, Swansea University, Fabian Way, Swansea SA1 8EN, UK.
authors: Luke
authors: L
authors: Burke
authors: Biomaterials, Biofouling and Biofilms Engineering Laboratory (B(3)EL), Systems and Process Engineering Centre, College of Engineering, Swansea University, Fabian Way, Swansea SA1 8EN, UK; Systems and Process Engineering Centre, College of Engineering, Swansea University, Fabian Way, Swansea SA1 8EN, UK.
authors: Chris J
authors: CJ
authors: Mortimer
authors: Systems and Process Engineering Centre, College of Engineering, Swansea University, Fabian Way, Swansea SA1 8EN, UK.
authors: Daniel J
authors: DJ
authors: Curtis
authors: Systems and Process Engineering Centre, College of Engineering, Swansea University, Fabian Way, Swansea SA1 8EN, UK.
authors: Aled R
authors: AR
authors: Lewis
authors: Systems and Process Engineering Centre, College of Engineering, Swansea University, Fabian Way, Swansea SA1 8EN, UK.
authors: Rhodri
authors: R
authors: Williams
authors: Centre for NanoHealth (CNH), Swansea University, Singleton Park, Swansea SA2 8PP, UK.
authors: Karl
authors: K
authors: Hawkins
authors: Systems and Process Engineering Centre, College of Engineering, Swansea University, Fabian Way, Swansea SA1 8EN, UK.
authors: Thierry G G
authors: TG
authors: Maffeis
authors: Biomaterials, Biofouling and Biofilms Engineering Laboratory (B(3)EL), Systems and Process Engineering Centre, College of Engineering, Swansea University, Fabian Way, Swansea SA1 8EN, UK; Systems and Process Engineering Centre, College of Engineering, Swansea University, Fabian Way, Swansea SA1 8EN, UK; Centre for NanoHealth (CNH), Swansea University, Singleton Park, Swansea SA2 8PP, UK. Electronic address: c.wright@swansea.ac.uk.
authors: Chris J
authors: CJ
authors: Wright
mesh_terms: D000067493:Dynamic Light Scattering; D005290:Ferric Compounds / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D057139:Nanofibers / Q000737:chemistry* / Q000648:ultrastructure; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D011092:Polyethylene Glycols / Q000737:chemistry; D011205:Povidone / Q000737:chemistry; D013052:Spectrometry, X-Ray Emission; D013054:Spectrophotometry, Atomic; D023822:Tissue Engineering / Q000379:methods*; D014961:X-Ray Diffraction
chemical_list: D005290:Ferric Compounds; C000499:ferric oxide; D011092:Polyethylene Glycols; D011205:Povidone
keywords: Electrospinning; Magnetic nanoparticles; Magnetite; Nanofibres; Nanoparticle synthesis; Scale-up