title: Regulatory roles of glutathione-S-transferases and 4-hydroxynonenal in stress-mediated signaling and toxicity.
abstract: Glutathione-S-Transferases (GSTs) have primarily been thought to be xenobiotic metabolizing enzymes that protect cells from toxic drugs and environmental electrophiles. However, in last three decades, these enzymes have emerged as the regulators of oxidative stress-induced signaling and toxicity. 4-Hydroxy-trans 2-nonenal (HNE) an end-product of lipid peroxidation, has been shown to be a major determinant of oxidative stress-induced signaling and toxicity. HNE is involved in signaling pathways, including apoptosis, proliferation, modulation of gene expression, activation of transcription factors/repressors, cell cycle arrest, and differentiation. In this article, available evidence for a major role of GSTs in the regulation of HNE-mediated cell signaling processes through modulation of the intracellular levels of HNE is discussed.
authors: Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA. Electronic address: Yogesh.Awasthi@live.unthsc.edu.
authors: Yogesh C
authors: YC
authors: Awasthi
authors: Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA. Electronic address: kvramana@utmb.edu.
authors: Kota V
authors: KV
authors: Ramana
authors: Department of Molecular and Medical Genetics, University of North Texas Health Science Center, Fort worth, TX 76107, USA.
authors: Pankaj
authors: P
authors: Chaudhary
authors: Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA.
authors: Satish K
authors: SK
authors: Srivastava
authors: Department of Internal Medicine-Oncology, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA.
authors: Sanjay
authors: S
authors: Awasthi
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics / Q000378:metabolism; D000447:Aldehydes / Q000378:metabolism*; D000818:Animals; D017209:Apoptosis / Q000235:genetics; D018797:Cell Cycle Proteins / Q000235:genetics / Q000378:metabolism*; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D002470:Cell Survival; D056970:Co-Repressor Proteins; D005786:Gene Expression Regulation; D005982:Glutathione Transferase / Q000235:genetics / Q000378:metabolism*; D000076249:Heat Shock Transcription Factors / Q000235:genetics / Q000378:metabolism; D006801:Humans; D015227:Lipid Peroxidation; D018832:Molecular Chaperones; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism; D018384:Oxidative Stress / Q000235:genetics*; D015398:Signal Transduction / Q000235:genetics*
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D000447:Aldehydes; D018797:Cell Cycle Proteins; D056970:Co-Repressor Proteins; C106985:DAXX protein, human; C000619706:HSF1 protein, human; D000076249:Heat Shock Transcription Factors; D018832:Molecular Chaperones; D009687:Nuclear Proteins; D005982:Glutathione Transferase; C027576:4-hydroxy-2-nonenal
keywords: 4-hydroxynonenal; Cell cycle; Cell signaling; Glutathione-S-transferases; Oxidative stress