title: A plant from the altiplano of Northern ChileSenecio nutans, inhibits theVibrio choleraepathogen.
abstract: BACKGROUND
  In the altiplano of Northern Chile the plantSenecio nutansis habitually used as an infusion to relieve the effects of altitude sickness (locally known as "puna"). It is also used to alleviate the bronchitis, whooping cough, asthma, stomachache, tiredness and fever. The extreme conditions under which these plant grow and scientific data that shows the inhibiting potential of the essential oils of plants of the genusSeneciorepresents great potential in the study of their application to control pathogens likeVibrio Cholera.
  
  
  METHODS
  The essential oil from aerial parts ofS. nutanswas isolated by hydrodistillation and the chemical composition characterized by GC-MS analyses. The antibacterial potential and determination of MIC value, was estimated in both micro and macro dilution method.
  
  
  RESULTS
  The GC-MS analysis of essential oil ofS. nutansshowed the presence of methyl cinnamate (44.9 %),p-cymenol (27.2 %), and terpinen-4-ol (6.8 %), α-terpineol (4.1 %),t-cadinol (3.5 %), methyl hydrocinnamate (2.1 %), δ-cadinene (2.0 %),p-cymene (1.9 %), γ-terpinene (1.8 %), α-cadinol (1.6 %),cis-sabinene hydrate (1.1 %), caryophyllene (0.9 %), β-pinene (0.8 %), and α-terpinene (0.6 %) as major components. Moreover, the oil ofS. nutansexhibited an important antibacterial activity with a diameter of inhibition zone growth of 22 mm and the MIC value of 0.4 mg/mL against pathogenic bacteriaV. cholerae.
  
  
  CONCLUSIONS
  The results show for the first time the antibacterial activity of the essential oils ofS. nutansagainst theV. choleraepathogen, an activity that can be applied as a preventive treatment against the action of pathogen.
authors: Laboratorio Química Biológica, Instituto Antofagasta (IA), Universidad de Antofagasta, Av. Universidad de Antofagasta, 02800 Antofagasta, Chile.
authors: Adrian
authors: A
authors: Paredes
authors: Laboratorio Mesocosmos Marino, Centro de Bioinnovación de Antofagasta (CBIA), Departamento de Biotecnología, Facultad de Ciencias del Mar y Recursos Biológicos, Universidad de Antofagasta, Av. Universidad de Antofagasta, 02800 Antofagasta, Chile.
authors: Yanett
authors: Y
authors: Leyton
authors: Laboratorio Mesocosmos Marino, Centro de Bioinnovación de Antofagasta (CBIA), Departamento de Biotecnología, Facultad de Ciencias del Mar y Recursos Biológicos, Universidad de Antofagasta, Av. Universidad de Antofagasta, 02800 Antofagasta, Chile.
authors: Carlos
authors: C
authors: Riquelme
authors: Laboratorio Química Biológica, Instituto Antofagasta (IA), Universidad de Antofagasta, Av. Universidad de Antofagasta, 02800 Antofagasta, Chile.
authors: Glauco
authors: G
authors: Morales
keywords: Antimicrobial activities; Chachacoma; Essential oils; Senecio nutans; Vibrio Cholerae