title: Relationship between Adverse Gastric Reactions and the Timing of Enteric-Coated Aspirin Administration.
abstract: OBJECTIVE
  This study aimed to elucidate the association between the adverse gastric effects of enteric-coated aspirin and the timing of its administration.
  
  
  METHODS
  The study population comprised 572 patients (age range 45-84 years) admitted to Huaiyin Hospital between August 2012 and October 2014. Patients were administered a 100 mg enteric-coated aspirin tablet once daily: before a meal (30 min before a meal), during a meal, after a meal (30 min after a meal), or before sleep, and all patients were followed up for 6-9 months to observe for adverse gastric reactions and other side effects. Gastroscopy was performed if indicated by the patient's condition after obtaining due consent. In addition, release tests for an enteric-coated aspirin tablet were conducted using the chromatography method.
  
  
  RESULTS
  Enteric-coated aspirin tablets released completely, with a release rate of >99 % under 20-120 min at pH > 5.5. Furthermore, the number of patients with recurring adverse stomach reactions was significantly lower in the before-meal and before-sleep groups than that observed in the during-meal and after-meal groups (p < 0.05). No significant between-group differences were observed with respect to damage to other organs. Similarly, the number of patients with gastric lesions was significantly lower in the before-meal and before-sleep groups than that observed in the during-meal and after-meal groups (p < 0.05).
  
  
  CONCLUSIONS
  The optimal time for once-daily administration of low-dose enteric-coated aspirin tablets was before a meal or before sleep owing to the increase in pH level during and after meals.
authors: Department of Cardiology, Huaiyin Hospital, No.38, Beijing West Road, Huaiyin District, Huai'an, 223300, Jiangsu Province, China. hylucky289@163.com.
authors: Weijun
authors: W
authors: Guo
authors: Department of Cardiology, Huaiyin Hospital, No.38, Beijing West Road, Huaiyin District, Huai'an, 223300, Jiangsu Province, China.
authors: Wenlin
authors: W
authors: Lu
authors: Department of Cardiology, Huaiyin Hospital, No.38, Beijing West Road, Huaiyin District, Huai'an, 223300, Jiangsu Province, China.
authors: Yujun
authors: Y
authors: Xu
authors: Department of Cardiology, Jiangsu Province People's Hospital, Nanjing, China.
authors: Liansheng
authors: L
authors: Wang
authors: Department of Cardiology, Huaiyin Hospital, No.38, Beijing West Road, Huaiyin District, Huai'an, 223300, Jiangsu Province, China.
authors: Qin
authors: Q
authors: Wei
authors: Department of Cardiology, Huaiyin Hospital, No.38, Beijing West Road, Huaiyin District, Huai'an, 223300, Jiangsu Province, China.
authors: Qingyun
authors: Q
authors: Zhao
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000009:adverse effects*; D001241:Aspirin / Q000008:administration & dosage* / Q000009:adverse effects*; D004334:Drug Administration Schedule; D005260:Female; D005773:Gastroscopy; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013272:Stomach Diseases / Q000139:chemically induced*; D013608:Tablets, Enteric-Coated
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D013608:Tablets, Enteric-Coated; D001241:Aspirin