title: Where does chemotherapy stands in the treatment of ampullary carcinoma? A review of literature.
abstract: Ampullary carcinoma (AC) is a rare gastrointestinal tumor without clear treatment recommendations. The management of this tumor is usually extrapolated from the treatment of pancreatic, biliary duct and intestinal cancers. Few papers have studied the AC as an independent entity and yet succombs to several limitations. These studies were retrospective single institutional experiences with limited sample sizes recruited over a long period of time. Unlike metastatic ACs where chemotherapy is the only recommended option, localized AC once excised may be approached by either chemotherapy alone or concomitant chemoradiation therapy. In this review, we report the overall survival and recurrence factors of more than 1000 patients from all the studies treating exclusively ACs. We also review the medical treatment of this tumor and conclude to the necessity of multi-institutional randomized controlled studies for AC exclusively.
authors: Marwan Ghosn, Hampig Raphael Kourie, Elie El Rassy, Fady Ghassan Haddad, Colette Hanna, Fadi El Karak, Department of Oncology, Faculty of Medicine, Saint Joseph University, Beirut 1104-2020, Lebanon.
authors: Marwan
authors: M
authors: Ghosn
authors: Marwan Ghosn, Hampig Raphael Kourie, Elie El Rassy, Fady Ghassan Haddad, Colette Hanna, Fadi El Karak, Department of Oncology, Faculty of Medicine, Saint Joseph University, Beirut 1104-2020, Lebanon.
authors: Hampig Raphael
authors: HR
authors: Kourie
authors: Marwan Ghosn, Hampig Raphael Kourie, Elie El Rassy, Fady Ghassan Haddad, Colette Hanna, Fadi El Karak, Department of Oncology, Faculty of Medicine, Saint Joseph University, Beirut 1104-2020, Lebanon.
authors: Elie
authors: E
authors: El Rassy
authors: Marwan Ghosn, Hampig Raphael Kourie, Elie El Rassy, Fady Ghassan Haddad, Colette Hanna, Fadi El Karak, Department of Oncology, Faculty of Medicine, Saint Joseph University, Beirut 1104-2020, Lebanon.
authors: Fady Ghassan
authors: FG
authors: Haddad
authors: Marwan Ghosn, Hampig Raphael Kourie, Elie El Rassy, Fady Ghassan Haddad, Colette Hanna, Fadi El Karak, Department of Oncology, Faculty of Medicine, Saint Joseph University, Beirut 1104-2020, Lebanon.
authors: Colette
authors: C
authors: Hanna
authors: Marwan Ghosn, Hampig Raphael Kourie, Elie El Rassy, Fady Ghassan Haddad, Colette Hanna, Fadi El Karak, Department of Oncology, Faculty of Medicine, Saint Joseph University, Beirut 1104-2020, Lebanon.
authors: Fadi
authors: F
authors: El Karak
authors: Marwan Ghosn, Hampig Raphael Kourie, Elie El Rassy, Fady Ghassan Haddad, Colette Hanna, Fadi El Karak, Department of Oncology, Faculty of Medicine, Saint Joseph University, Beirut 1104-2020, Lebanon.
authors: Dolly
authors: D
authors: Nasr
keywords: Ampullary cancer; Novel therapies; Prognostic factors; Review; Treatment