title: Plasma Adiponectin and Hepatocellular Carcinoma Survival Among Patients Without Liver Transplantation.
abstract: To investigate the levels of leptin and adiponectin in prediction of hepatocellular carcinoma (HCC) survival among patients without liver transplantation.
  
  
  
  We measured pretreatment plasma leptin and adiponectin in 172 HCC cases who were prospectively followed-up over 7 years.
  
  
  
  Gender, hepatitis B virus (HBV) and hepatitis C virus (HCV) infection, high body mass index (BMI), diabetes mellitus (DM) history and Child-Pugh (CP) class were associated with leptin and adiponectin levels, while α-fetoprotein (AFP) and presence of metastasis, being outside the Milan criteria and Barcelona clinic liver cancer (BCLC) stage, were significantly associated with liver transplantation and HCC survival. No significant association was observed for leptin or adiponectin and HCC survival in the overall group. In subgroup analyses among those without liver transplantation, we found significant associations between metastasis, Milan criteria, BCLC stage, hepatitis B surface antigen (HBsAg) and HCC survival. When separately determining the Cox proportional hazard models and Kaplan-Meier survival curves by liver transplantation status, higher adiponectin was significantly associated with an increased hazard ratio (HR) of death of 1.72 (95% confidence interval (CI)=1.12-2.64), i.e. poor survival among patients without liver transplantation. A multivariate Cox proportional hazard model, including adiponectin, CP class, presence of metastasis, tumor outside of Milan criteria, AFP and BCLC stage B/C parameters, also showed significant association with poor HCC survival (likelihood ratio test p<0.0001). No significant impact was observed for leptin on HCC survival regardless of liver transplantation status.
  
  
  
  Higher levels of plasma adiponectin may predict poor HCC survival among patients without liver transplantation.
authors: Departments of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, U.S.A. js2182@cumc.columbia.edu.|Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, U.S.A.
authors: Jing
authors: J
authors: Shen
authors: Departments of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, U.S.A.|School of Public Health, College of Public Health and Nutrition, Taipei Medical University, Taipei, Taiwan, R.O.C.
authors: Chih-Ching
authors: CC
authors: Yeh
authors: Departments of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, U.S.A.
authors: Qiao
authors: Q
authors: Wang
authors: Departments of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, U.S.A.
authors: Irina
authors: I
authors: Gurvich
authors: Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, U.S.A.|Department of Medicine, College of Physicians and Surgeons, Columbia University Medical Center, New York, NY, U.S.A.
authors: Abby B
authors: AB
authors: Siegel
authors: Departments of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, U.S.A.|Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, U.S.A.
authors: Regina M
authors: RM
authors: Santella
mesh_terms: D052242:Adiponectin / Q000097:blood*; D006528:Carcinoma, Hepatocellular / Q000097:blood* / Q000473:pathology / Q000601:surgery; D005260:Female; D006509:Hepatitis B / Q000097:blood; D006526:Hepatitis C / Q000097:blood; D006801:Humans; D020738:Leptin / Q000097:blood; D008113:Liver Neoplasms / Q000097:blood* / Q000473:pathology / Q000601:surgery; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D016016:Proportional Hazards Models; D000509:alpha-Fetoproteins / Q000032:analysis
chemical_list: C499918:ADIPOQ protein, human; C097353:AFP protein, human; D052242:Adiponectin; D020738:Leptin; D000509:alpha-Fetoproteins
keywords: Adiponectin; HCC; leptin; liver transplantation; survival