title: Brief Report: Impaired CD4 T-Cell Response to Autophagy in Treated HIV-1-Infected Individuals.
abstract: Autophagy restricts infection of CD4 T lymphocytes by HIV-1, but little is known about autophagy in treated HIV-1-infected individuals. We have analyzed the capability of CD4 T cells from aviremic-treated individuals to trigger autophagy and correlated this response with parameters known to be important for immunological recovery. Autophagy was significantly decreased in CD4 T cells from HIV-1-treated individuals compared with uninfected controls, and this defective autophagic response was more pronounced in individuals with poor CD4 T-cell recovery, suggesting a link between impaired autophagy in CD4 T cells and chronic immunological defects that remain in treated HIV infection.
authors: *Institut de Recerca de la Sida IrsiCaixa-HIVACAT, Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, IGTP, UAB, Badalona, Spain; †Centre d'Études d'Agents Pathogènes et Biotechnologies pour la Santé, CPBS, FRE 3689-CNRS-University of Montpellier, Montpellier, France; ‡Department of Microbiology, Infectiology and Immunology, Faculté de Médecine, Centre de Recherche du CHUM, Université de Montréal, Montréal, Québec, Canada; §Fundació Lluita contra la SIDA, Hospital Germans Trias i Pujol, Badalona, Spain; and ‖Universitat de Vic-UCC, Vic, Spain.
authors: Elisabet
authors: E
authors: Gómez-Mora
authors: Véronique
authors: V
authors: Robert-Hebmann
authors: Elisabet
authors: E
authors: García
authors: Marta
authors: M
authors: Massanella
authors: Bonaventura
authors: B
authors: Clotet
authors: Cecilia
authors: C
authors: Cabrera
authors: Julià
authors: J
authors: Blanco
authors: Martine
authors: M
authors: Biard-Piechaczyk
mesh_terms: D000328:Adult; D044966:Anti-Retroviral Agents / Q000627:therapeutic use*; D001343:Autophagy; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D003430:Cross-Sectional Studies; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology* / Q000821:virology; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects
chemical_list: D044966:Anti-Retroviral Agents