title: Prognostic role of extracellular matrix metalloproteinase inducer/CD147 in gastrointestinal cancer: a meta-analysis of related studies.
abstract: The prognostic role of Extracellular matrix metalloproteinase inducer (EMMPRIN/ CD147) in gastrointestinal cancer remains controversial. We systematically reviewed the evidence of assessment of CD147 expression in gastrointestinal cancer to help clarify this issue. Pubmed, Embase, Cochrane Library and Web of Science databases were searched to identify eligible studies to evaluate the association of CD147 expression and disease-free and overall survival of gastrointestinal cancer. Hazard ratios (HRs) were pooled to estimate the effect. CD147 overexpression was significantly correlated with poor disease-free survival (HR 2.38, 95% CI 1.43-3.97) and overall survival (HR 1.64, 95% CI 1.25-2.14) of cancer patients. Furthermore, CD147 overexpression was significantly association with TNM stage (TIII/TIV vs TI/TII: OR 3.60, 95% CI 1.85-7.01), the depth of invasion (T3/T4 vs T1/T2: OR 2.04, 95% CI 1.25-3.33), lymph node metastasis (positive vs negative: 2.35, 95% CI 1.14-4.86), distant metastasis (positive vs negative: OR 4.78, 95% CI 1.43-16.00). Our analyses demonstrate that CD147 was effectively predictive of worse prognosis in gastrointestinal cancer. Moreover, Identifying CD147 may help identify new drug targets for cancer therapy.
authors: Department of General Surgery, Chinese People's Liberation Army General Hospital, Beijing 100853, China.
authors: Xiaohui
authors: X
authors: Huang
authors: Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China.
authors: Weisong
authors: W
authors: Shen
authors: Department of General Surgery, Chinese People's Liberation Army General Hospital, Beijing 100853, China.
authors: Hongqing
authors: H
authors: Xi
authors: Department of General Surgery, Chinese People's Liberation Army General Hospital, Beijing 100853, China.
authors: Kecheng
authors: K
authors: Zhang
authors: Department of General Surgery, Chinese People's Liberation Army General Hospital, Beijing 100853, China.
authors: Jianxin
authors: J
authors: Cui
authors: Department of General Surgery, Chinese People's Liberation Army General Hospital, Beijing 100853, China.
authors: Bo
authors: B
authors: Wei
authors: Department of General Surgery, Chinese People's Liberation Army General Hospital, Beijing 100853, China.
authors: Lin
authors: L
authors: Chen
mesh_terms: D051926:Basigin / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000378:metabolism*; D018450:Disease Progression; D018572:Disease-Free Survival; D005770:Gastrointestinal Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology / Q000628:therapy; D006801:Humans; D008207:Lymphatic Metastasis; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D016017:Odds Ratio; D018570:Risk Assessment; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome; D015854:Up-Regulation
chemical_list: C497886:BSG protein, human; D014408:Biomarkers, Tumor; D051926:Basigin
keywords: CD147; gastrointestinal cancer; meta-analysis; prognosis