title: Lipids and Their Trafficking: An Integral Part of Cellular Organization.
abstract: An evolutionarily conserved feature of cellular organelles is the distinct phospholipid composition of their bounding membranes, which is essential to their identity and function. Within eukaryotic cells, two major lipid territories can be discerned, one centered on the endoplasmic reticulum and characterized by membranes with lipid packing defects, the other comprising plasma-membrane-derived organelles and characterized by membrane charge. We discuss how this cellular lipid organization is maintained, how lipid flux is regulated, and how perturbations in cellular lipid homeostasis can lead to disease.
authors: Institut Jacques Monod, CNRS, UMR 7592, Université Paris Diderot, Sorbonne Paris Cité, 75013 Paris, France. Electronic address: cathy.jackson@ijm.fr.
authors: Catherine L
authors: CL
authors: Jackson
authors: Institut Jacques Monod, CNRS, UMR 7592, Université Paris Diderot, Sorbonne Paris Cité, 75013 Paris, France.
authors: Laurence
authors: L
authors: Walch
authors: Institut Jacques Monod, CNRS, UMR 7592, Université Paris Diderot, Sorbonne Paris Cité, 75013 Paris, France.
authors: Jean-Marc
authors: JM
authors: Verbavatz
mesh_terms: D000818:Animals; D002477:Cells / Q000378:metabolism*; D060833:Cellular Microenvironment; D006801:Humans; D050356:Lipid Metabolism; D008055:Lipids / Q000737:chemistry*; D015388:Organelles / Q000378:metabolism; D017433:Protein Structure, Secondary
chemical_list: D008055:Lipids
keywords: Golgi; VAP (VAMP-associated protein); amphipathic helix; cellular organization; endoplasmic recticulum; lipid transfer protein (LTP); lipid transport; membrane contact site; membrane packing defect; plasma membrane