title: Irritable bowel syndrome and inflammatory bowel disease overlap syndrome: pieces of the puzzle are falling into place.
abstract: Irritable bowel syndrome (IBS), a common gastrointestinal disorder involving the gut-brain axis, and inflammatory bowel disease (IBD), a chronic relapsing inflammatory disorder, are both increasing in incidence and prevalence in Asia. Both have significant overlap in terms of symptoms, pathophysiology, and treatment, suggesting the possibility of IBS and IBD being a single disease entity albeit at opposite ends of the spectrum. We examined the similarities and differences in IBS and IBD, and offer new thoughts and approaches to the disease paradigm.
authors: Gastroenterology Unit, Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh, Malaysia.
authors: Rafiz
authors: R
authors: Abdul Rani
authors: Gastroenterology Unit, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
authors: Raja Affendi
authors: RA
authors: Raja Ali
authors: School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Malaysia.
authors: Yeong Yeh
authors: YY
authors: Lee
keywords: Gut-brain axis; IBS-IBD overlap syndrome; Inflammatory bowel disease; Irritable bowel syndrome