title: Significance of Time-Zero Biopsy for Graft Renal Function After Deceased Donor Kidney Transplantation.
abstract: BACKGROUND
  Donor organ quality from deceased donors affects graft survival after kidney transplantation. This study was performed to identify clinico-histological factors that affect early graft outcome, using time-zero biopsies of deceased donors.
  
  
  METHODS
  Between December 2006 and July 2011, 135 recipients of deceased donor kidneys were included, and data concerning donor and recipient-related clinical characteristics and histological findings of time-zero biopsies categorized by use of the Banff 07 scoring system were included in the analysis. Mean donor age was 44.3 ± 12.3 years. Mean terminal serum creatinine level and cold ischemic time were 1.50 ± 0.96 mg/dL and 349 ± 166 minutes. Mean follow-up time after transplantation was 37 ± 16 months, and all recipients were followed for at least 1 year.
  
  
  RESULTS
  Global glomerulosclerosis (38.5%), tubular atrophy (37.8%), arteriolar hyaline thickening (25.9%), interstitial fibrosis (23%), vascular fibrous intimal thickening (21.5%), and interstitial inflammation (20%) were the major pathologic findings of time-zero biopsies. The majority of pathologic scores were of mild degree. Among histological findings, arteriolar hyaline thickening and interstitial fibrosis were only significantly associated with early post-transplant renal function in multivariate analyses.
  
  
  CONCLUSIONS
  Considerations of clinico-histological findings were found to be valuable for predicting early graft outcome after deceased donor kidney transplantation.
authors: Department of Surgery, Yonsei University College of Medicine, Seoul, Korea; Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, Korea.
authors: A L
authors: AL
authors: Lee
authors: Department of Surgery, Yonsei University College of Medicine, Seoul, Korea; Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, Korea.
authors: K H
authors: KH
authors: Huh
authors: Department of Surgery, Ajou University School of Medicine, Suwon, Korea.
authors: S H
authors: SH
authors: Lee
authors: Department Surgery, CHA Bundang Medical Center, CHA University, Seongnam, Korea.
authors: J J
authors: JJ
authors: Lee
authors: Department of Surgery, Yonsei University College of Medicine, Seoul, Korea; Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, Korea.
authors: D J
authors: DJ
authors: Joo
authors: Department of Pathology, Yonsei University College of Medicine, Seoul, Korea.
authors: H J
authors: HJ
authors: Jeong
authors: Department of Surgery, Yonsei University College of Medicine, Seoul, Korea; Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, Korea. Electronic address: ysms91@yuhs.ac.
authors: M S
authors: MS
authors: Kim
authors: Department of Surgery, Yonsei University College of Medicine, Seoul, Korea; Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, Korea.
authors: S I
authors: SI
authors: Kim
authors: Department of Surgery, Yonsei University College of Medicine, Seoul, Korea; Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, Korea.
authors: Y S
authors: YS
authors: Kim
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D005260:Female; D006085:Graft Survival; D006801:Humans; D007668:Kidney / Q000473:pathology*; D016030:Kidney Transplantation / Q000401:mortality; D008297:Male; D008875:Middle Aged; D014019:Tissue Donors; D019737:Transplants / Q000473:pathology*; D016896:Treatment Outcome