title: Cytotoxic lanostanes from fruits of Garcinia wallichii Choisy (Guttiferae).
abstract: Five new lanostanes, wallichinanes A-E (1-5) together with a known lanostane derivative 6 were isolated from the cytotoxic hexanes extract of fruits of Garcinia wallichii Choisy (Guttiferae). The structures of the isolated compounds were established by analysis of spectroscopic data, X-ray diffraction technique as well as comparison with the literature data. The cytotoxicity of all isolated compounds against a panel of cultured cancer cell lines was evaluated. Compound 4 exhibited good cytotoxicity with ED50values ranging from 3.91 to 7.63μM.
authors: Department of Chemistry and Center of Excellence for Innovation in Chemistry (PERCH-CIC), Faculty of Science, Mahidol University, Rama 6 Road, Bangkok 10400, Thailand.
authors: Sakchai
authors: S
authors: Hongthong
authors: Department of Chemistry and Center of Excellence for Innovation in Chemistry (PERCH-CIC), Faculty of Science, Mahidol University, Rama 6 Road, Bangkok 10400, Thailand.
authors: Jatuporn
authors: J
authors: Meesin
authors: Chulabhorn Research Institute, Kamphaeng Phet 6 Road, Laksi, Bangkok 10210, Thailand.
authors: Phanruethai
authors: P
authors: Pailee
authors: Department of Chemistry and Center of Excellence for Innovation in Chemistry (PERCH-CIC), Faculty of Science, Mahidol University, Rama 6 Road, Bangkok 10400, Thailand.
authors: Darunee
authors: D
authors: Soorukram
authors: Department of Chemistry and Center of Excellence for Innovation in Chemistry (PERCH-CIC), Faculty of Science, Mahidol University, Rama 6 Road, Bangkok 10400, Thailand.
authors: Palangpon
authors: P
authors: Kongsaeree
authors: Department of Chemistry and Center of Excellence for Innovation in Chemistry (PERCH-CIC), Faculty of Science, Mahidol University, Rama 6 Road, Bangkok 10400, Thailand.
authors: Samran
authors: S
authors: Prabpai
authors: Department of Physiology, Faculty of Science, Mahidol University, Rama 6 Road, Bangkok 10400, Thailand.
authors: Pawinee
authors: P
authors: Piyachaturawat
authors: Department of Physiology, Faculty of Science, Mahidol University, Rama 6 Road, Bangkok 10400, Thailand.
authors: Surawat
authors: S
authors: Jariyawat
authors: Department of Physiology, Faculty of Science, Mahidol University, Rama 6 Road, Bangkok 10400, Thailand.
authors: Kanoknetr
authors: K
authors: Suksen
authors: Mahidol University, Kanchanaburi Campus, Saiyok, Kanchanaburi 71150, Thailand.
authors: Thaworn
authors: T
authors: Jaipetch
authors: The Forest Herbarium National Park, Wildlife and Plant Conservation Department, Ministry of Natural Resources and Environment, Bangkok, Thailand.
authors: Narong
authors: N
authors: Nuntasaen
authors: Department of Chemistry and Center of Excellence for Innovation in Chemistry (PERCH-CIC), Faculty of Science, Mahidol University, Rama 6 Road, Bangkok 10400, Thailand.
authors: Vichai
authors: V
authors: Reutrakul
authors: Department of Chemistry and Center of Excellence for Innovation in Chemistry (PERCH-CIC), Faculty of Science, Mahidol University, Rama 6 Road, Bangkok 10400, Thailand. Electronic address: chutima.kon@mahidol.ac.th.
authors: Chutima
authors: C
authors: Kuhakarn
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D005638:Fruit / Q000737:chemistry; D029760:Garcinia / Q000737:chemistry*; D006801:Humans; D007810:Lanosterol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D008958:Models, Molecular; D009369:Neoplasms / Q000188:drug therapy; D014961:X-Ray Diffraction
chemical_list: D000972:Antineoplastic Agents, Phytogenic; C000620857:wallichinane D; D007810:Lanosterol
keywords: Cytotoxicity; Garcinia wallichii; Guttiferae; Lanostane; Triterpene