title: Human NK Cell Subsets Redistribution in Pathological Conditions: A Role for CCR7 Receptor.
abstract: Innate and adaptive immunity has evolved complex molecular mechanisms regulating immune cell migration to facilitate the dynamic cellular interactions required for its function involving the chemokines and their receptors. One important chemokine receptor in the immune system is represented by CCR7. Together with its ligands CCL19 and CCL21, this chemokine receptor controls different arrays of migratory events, both in innate and adaptive immunity, including homing of CD56brightNK cells, T cells, and DCs to lymphoid compartments, where T cell priming occurs. Only recently, a key role for CCR7 in promoting CD56dimNK cell migration toward lymphoid tissues has been described. Remarkably, this event can influence the shaping and polarization of adaptive T cell responses. In this review, we describe recent progress in understanding the mechanisms and the site where CD56dimKIR+NK cells can acquire the capability to migrate toward lymph nodes. The emerging significance of this event in clinical transplantation is also discussed.
authors: Dipartimento di Medicina Sperimentale, Università degli Studi di Genova , Genova , Italy.
authors: Silvia
authors: S
authors: Pesce
authors: Dipartimento di Immunologia, IRCCS Bambino Gesù Ospedale Pediatrico , Rome , Italy.
authors: Lorenzo
authors: L
authors: Moretta
authors: Dipartimento di Medicina Sperimentale, Università degli Studi di Genova, Genova, Italy; CEBR, Università degli Studi di Genova, Genova, Italy.
authors: Alessandro
authors: A
authors: Moretta
authors: Dipartimento di Medicina Sperimentale, Università degli Studi di Genova, Genova, Italy; CEBR, Università degli Studi di Genova, Genova, Italy.
authors: Emanuela
authors: E
authors: Marcenaro
keywords: CCR7; NK cell subsets; alloreactivity; human NK cells; immune checkpoint; transplantation