title: Synthesis, characterization, and antioxidant activity of Zn2+and Cu2+coordinated polyhydroxychalcone complexes.
abstract: Four new metal complexes [Cu(ISO)2], [Cu(BUT)2] and [Zn(ISO)2], [Zn(BUT)2] of the polyhydroxychalcones (isoliquiritigenin and butein) are synthesized, structurally characterized and their antioxidant activity is investigated. The formation of the complexes [Cu(ISO)2] and [Zn(ISO)2] is followed by Job's plot using NMR titration. The resulting compounds are characterized by mass spectrometry, IR spectroscopy, and elemental analysis. Studies on the radical scavenging activity are performed using DPPH as substrate. The results showed that the antioxidant activities of isoliquiritigenin and butein are enhanced after binding to copper or zinc.
authors: Institut für Biophysikalische Chemie, Fakultät für Chemie, Universität Wien, Althanstraße 14, 1090 Vienna, Austria.
authors: Chiara
authors: C
authors: Sulpizio
authors: Institut für Biophysikalische Chemie, Fakultät für Chemie, Universität Wien, Althanstraße 14, 1090 Vienna, Austria.
authors: Simon T R
authors: ST
authors: Müller
authors: Institut für Biophysikalische Chemie, Fakultät für Chemie, Universität Wien, Althanstraße 14, 1090 Vienna, Austria.
authors: Qi
authors: Q
authors: Zhang
authors: Institut für Organische Chemie, Fakultät für Chemie, Universität Wien, Währinger Straße 38, 1090 Vienna, Austria.
authors: Lothar
authors: L
authors: Brecker
authors: Institut für Biophysikalische Chemie, Fakultät für Chemie, Universität Wien, Althanstraße 14, 1090 Vienna, Austria.
authors: Annette
authors: 0000-0002-5919-0553
authors: A
authors: Rompel
keywords: Bioinorganic chemistry; Carbonyl compounds; Metal complex; NMR spectroscopy; Structure activity relationship