title: Cytokine Profile in Chronic Periodontitis Patients with and without Obesity: A Systematic Review and Meta-Analysis.
abstract: To investigate the cytokine profile as biomarkers in the gingival crevicular fluid (GCF) of chronic periodontitis (CP) patients with and without obesity, MEDLINE/PubMed, EMBASE, ScienceDirect, and SCOPUS databases were combined with handsearching of articles published from 1977 up to May 2016 using relevant MeSH terms. Meta-analyses were conducted separately for each of the cytokines: resistin, adiponectin, TNF-α, leptin, IL-6, IL-8, and IL-1β. Forest plots were produced reporting standardized mean difference of outcomes and 95% confidence intervals. Eleven studies were included. Three studies showed comparable levels of leptin among obese and nonobese patients with CP. Four studies reported comparable levels of interleukin- (IL-) 6 and resistin whereas five studies reported comparable levels of adiponectin. Two studies reported similar levels of CRP in patients with periodontitis with and without obesity. One study showed higher levels of tumor necrosis factor-alpha in obese patients with CP. One study showed higher levels of IL-1βand IL-8 in obese patients with CP. The level of localized periodontal inflammation may have a greater influence on the GCF proinflammatory biomarker levels as compared to systemic obesity. Whether patients having chronic periodontitis with obesity have elevated proinflammatory GCF biomarkers levels compared to nonobese individuals remains debatable.
authors: Department of Periodontology, Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia; Department of Periodontology, Faculty of Dentistry, Ziauddin University, Karachi, Pakistan.
authors: Zohaib
authors: 0000-0001-9618-8818
authors: Z
authors: Akram
authors: Department of Prosthetic Dental Sciences, College of Dentistry, King Saud University, Riyadh, Saudi Arabia.
authors: Tariq
authors: T
authors: Abduljabbar
authors: Department of Restorative Dentistry, Faculty of Dentistry, MARA University of Technology, Selangor, Malaysia.
authors: Mohamed Ibrahim
authors: MI
authors: Abu Hassan
authors: Department of General Dentistry, Eastman Institute for Oral Health, University of Rochester, Rochester, NY 14620, USA.
authors: Fawad
authors: 0000-0002-9253-1989
authors: F
authors: Javed
authors: Department of Prosthetic Dental Sciences, College of Dentistry, King Saud University, Riyadh, Saudi Arabia.
authors: Fahim
authors: F
authors: Vohra
mesh_terms: D015415:Biomarkers / Q000378:metabolism*; D055113:Chronic Periodontitis / Q000209:etiology / Q000378:metabolism*; D016207:Cytokines / Q000378:metabolism*; D006801:Humans; D009765:Obesity / Q000150:complications / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D016207:Cytokines