title: Intranasal Dexmedetomidine Sedation as Adjuvant Therapy in Acute Asthma Exacerbation With Marked Anxiety and Agitation.
abstract: We describe 2 patients with acute asthma exacerbation who were admitted to the emergency department (ED) with severe agitation and restlessness as a prominent finding, for which bedside asthma treatment sedation with intranasal dexmedetomidine was performed. In both cases, dexmedetomidine allowed the patients to rest and improved tolerance to treatment. Dexmedetomidine is a unique sedative with an excellent safety profile and minimal effect on respiratory function. These properties render it particularly promising for the management of severe agitation in children admitted to the ED with acute asthma exacerbation.
authors: Institute for Maternal and Child Health IRCCS Burlo Garofolo, Trieste, Italy.
authors: Giorgio
authors: G
authors: Cozzi
authors: University of Trieste, Trieste, Italy. Electronic address: saralega83@gmail.com.
authors: Sara
authors: S
authors: Lega
authors: Institute for Maternal and Child Health IRCCS Burlo Garofolo, Trieste, Italy.
authors: Rita
authors: R
authors: Giorgi
authors: Institute for Maternal and Child Health IRCCS Burlo Garofolo, Trieste, Italy.
authors: Egidio
authors: E
authors: Barbi
mesh_terms: D000208:Acute Disease; D000281:Administration, Intranasal; D001007:Anxiety / Q000188:drug therapy* / Q000209:etiology; D001249:Asthma / Q000188:drug therapy* / Q000523:psychology; D002675:Child, Preschool; D020927:Dexmedetomidine / Q000008:administration & dosage / Q000627:therapeutic use*; D004636:Emergency Service, Hospital; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000627:therapeutic use*; D007223:Infant; D011595:Psychomotor Agitation / Q000188:drug therapy* / Q000209:etiology
chemical_list: D006993:Hypnotics and Sedatives; D020927:Dexmedetomidine