title: Evaluation of potent phytomedicine for treatment of psoriasis using UV radiation induced psoriasis in rats.
abstract: The aim of present study was to determine the effect of newly formulated gels and suspensions of extractive Phytoconstituents of Woodfordia fructicosa flowers and Gardenia gummifera leaves by using UV Radiation induced psoriasis in rats. Both plants are traditionally claimed to be useful in treatment of number of skin diseases. However, there are no established scientific reports for their potential in psoriasis. Formulated Gels and Suspensions of ethanolic extract of both plants were tested for acute dermal and oral toxicity study respectively. The results of acute dermal toxicity at concentration 1% w/w and oral toxicity at dose 1000mg/kg showed that the gels and suspensions were safe. Psoriasis was induced in Wistar rats by espousing 10% area of total body by UV radiations. Anti-psoriatic activity was performed by applying 0.1% gel and orally at a dose 100mg/kg body weight in rats. Severity Index, histological study and biochemical estimation were analyzed. The results of our studies showed that the test formulations (Gels and Suspensions) of both plant extracts exhibited potential effect in anti-psoriatic activity.
authors: Bhupal Nobles' College of Pharmacy, Udaipur 313002, India. Electronic address: hemant_nagar81@yahoo.co.in.
authors: Hemant K
authors: HK
authors: Nagar
authors: Indian Institute of Integrative Medicine, (Council of Scientific & Industrial Research), Jammu- 180001, India.
authors: Amit K
authors: AK
authors: Srivastava
authors: Moradabad Educational Trust, Group of Institutions, Faculty of Pharmacy, Moradabad 244001, India.
authors: Rajnish
authors: R
authors: Srivastava
authors: Bhupal Nobles' College of Pharmacy, Udaipur 313002, India.
authors: Mahendra S
authors: MS
authors: Ranawat
mesh_terms: D000279:Administration, Cutaneous; D000284:Administration, Oral; D000818:Animals; D003879:Dermatologic Agents / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D004195:Disease Models, Animal; D000431:Ethanol / Q000737:chemistry; D005260:Female; D032062:Gardenia; D005782:Gels; D006909:Hydroxyproline / Q000378:metabolism; D008297:Male; D019999:Pharmaceutical Solutions; D008517:Phytotherapy; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D010946:Plants, Medicinal; D011565:Psoriasis / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D017208:Rats, Wistar; D012720:Severity of Illness Index; D012867:Skin / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D012997:Solvents / Q000737:chemistry; D014466:Ultraviolet Rays; D031565:Woodfordia
chemical_list: D003879:Dermatologic Agents; D005782:Gels; D019999:Pharmaceutical Solutions; D010936:Plant Extracts; D012997:Solvents; D000431:Ethanol; D006909:Hydroxyproline
keywords: Epidermal thickness; Gardenia gummifera; Hydroxyproline content; Psoriasis; Severity index; UV radiation; Woodfordia fructicosa