title: Treatment outcomes of drug-resistant tuberculosis patients in Kenya.
abstract: Successful treatment of drug-resistant tuberculosis (DR-TB) is crucial in preventing disease transmission and reducing related morbidity and mortality. A standardised DR-TB treatment regimen is used in Kenya. Although patients on treatment are monitored, no evaluation of factors affecting treatment outcomes has yet been performed.
  
  
  
  To analyse treatment outcomes of DR-TB patients in Kenya and factors associated with successful outcome.
  
  
  
  Retrospective analysis of secondary data from Kenya's National Tuberculosis, Leprosy and Lung disease programme. DR-TB data from the national database for January to December 2012 were reviewed.
  
  
  
  Of 205 DR-TB patients included in the analysis, 169 (82.4%) had a successful treatment outcome, 18 (9%) died and 18 (9%) were lost to follow-up. Only sex (P = 0.006) and human immunodeficiency virus (HIV) status (P = 0.008) were predictors of successful treatment. Females were more likely to attain treatment success (OR 3.86, 95%CI 1.47-10.12), and HIV-negative status increased the likelihood of successful treatment (OR 3.53, 95%CI 1.4-8.9).
  
  
  
  Treatment success rates were higher than World Health Organization targets. Targeted policies for HIV-positive patients and males will improve treatment outcomes in these groups.
authors: National Tuberculosis, Leprosy and Lung Disease Programme, Nairobi, Kenya.
authors: D J
authors: DJ
authors: Mibei
authors: National Tuberculosis, Leprosy and Lung Disease Programme, Nairobi, Kenya.
authors: J W
authors: JW
authors: Kiarie
authors: Centre for Health Solutions, Nairobi, Kenya.
authors: A
authors: A
authors: Wairia
authors: National Tuberculosis, Leprosy and Lung Disease Programme, Nairobi, Kenya.
authors: M
authors: M
authors: Kamene
authors: M E
authors: ME
authors: Okumu
mesh_terms: D000293:Adolescent; D000328:Adult; D000995:Antitubercular Agents / Q000627:therapeutic use*; D015992:Body Mass Index; D002648:Child; D002675:Child, Preschool; D004032:Diet; D005260:Female; D015658:HIV Infections / Q000188:drug therapy; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007630:Kenya / Q000453:epidemiology; D059012:Lost to Follow-Up; D008297:Male; D008875:Middle Aged; D009752:Nutritional Status; D017149:Private Sector; D017150:Public Sector; D012189:Retrospective Studies; D016896:Treatment Outcome; D018088:Tuberculosis, Multidrug-Resistant / Q000188:drug therapy* / Q000453:epidemiology*; D014944:World Health Organization; D055815:Young Adult
chemical_list: D000995:Antitubercular Agents