title: Systematic review and meta-analysis on laparoscopic pancreatic resections for neuroendocrine neoplasms (PNENs).
abstract: The safety of laparoscopic resections (LPS) of pancreatic neuroendocrine neoplasms (PNENs) has been well established in the literature. Areas covered: Studies conducted between January 2003 and December 2015 that reported on LPS and open surgery (OPS) were reviewed. The primary outcomes were the rate of post-operative complications and the length of hospital stay (LoS) after laparoscopic and open surgical resection. The rate of recurrence was the secondary outcome. Eleven studies were included with a total of 907 pancreatic resections for PNENs, of whom, 298 (32.8%) underwent LPS and 609 (67.2%) underwent open surgery. LPS resulted in a significantly shorter LoS (p < 0.0001) and lower blood loss (p < 0.0001). The meta-analysis did not show any significant difference in the pancreatic fistula rate, recurrence rate or post-operative mortality between the two groups. Expert commentary: LPS is a safe approach even for PNENs and it is associated with a shorter LoS.
authors: a HPB and Liver Transplant Surgery , Royal Free Hospital, NHS Foundation Trust , London , UK.
authors: Domenico
authors: D
authors: Tamburrino
authors: b Pancreatic surgery Unit, Pancreas Translational & Clinical Research Center - IRCCS San Raffaele Scientific Institute , 'Vita e Salute' University , Milan , Italy.
authors: Stefano
authors: S
authors: Partelli
authors: c Department of General and Oncologic Surgery , University of Perugia, St. Mary's Hospital , Terni , Italy.
authors: Claudio
authors: C
authors: Renzi
authors: b Pancreatic surgery Unit, Pancreas Translational & Clinical Research Center - IRCCS San Raffaele Scientific Institute , 'Vita e Salute' University , Milan , Italy.
authors: Stefano
authors: S
authors: Crippa
authors: b Pancreatic surgery Unit, Pancreas Translational & Clinical Research Center - IRCCS San Raffaele Scientific Institute , 'Vita e Salute' University , Milan , Italy.
authors: Francesca
authors: F
authors: Muffatti
authors: b Pancreatic surgery Unit, Pancreas Translational & Clinical Research Center - IRCCS San Raffaele Scientific Institute , 'Vita e Salute' University , Milan , Italy.
authors: Carolina
authors: C
authors: Perali
authors: d Department of Digestive Surgery , University of Perugia, St. Mary's Hospital , Terni , Italy.
authors: Amilcare
authors: A
authors: Parisi
authors: e Tift College of Education , Mercer University , Atlanta , GA , USA.
authors: Justus
authors: J
authors: Randolph
authors: a HPB and Liver Transplant Surgery , Royal Free Hospital, NHS Foundation Trust , London , UK.
authors: Giuseppe Kito
authors: GK
authors: Fusai
authors: c Department of General and Oncologic Surgery , University of Perugia, St. Mary's Hospital , Terni , Italy.
authors: Roberto
authors: R
authors: Cirocchi
authors: b Pancreatic surgery Unit, Pancreas Translational & Clinical Research Center - IRCCS San Raffaele Scientific Institute , 'Vita e Salute' University , Milan , Italy.
authors: Massimo
authors: M
authors: Falconi
mesh_terms: D016063:Blood Loss, Surgical; D016009:Chi-Square Distribution; D006801:Humans; D010535:Laparoscopy / Q000009:adverse effects / Q000401:mortality; D007902:Length of Stay; D009364:Neoplasm Recurrence, Local; D018358:Neuroendocrine Tumors / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D016017:Odds Ratio; D010180:Pancreatectomy / Q000009:adverse effects / Q000379:methods* / Q000401:mortality; D010185:Pancreatic Fistula / Q000209:etiology; D010190:Pancreatic Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome
keywords: Pancreatic surgery; laparoscopic pancreatic resection; laparoscopy; minimally invasive surgery; neuroendocrine neoplasms