title: [Fine particulate matter and nonalcoholic fatty liver disease].
abstract: Fine particulate matter is defined as the particulate matter with an aerodynamic diameter of < 2.5 μm, i.e., PM2.5. Its surface absorbs large amounts of toxic and hazardous substances, which can deposit in pulmonary alveoli through respiration and reach other organs through pulmonary ventilation. Many studies have confirmed that PM2.5 is closely associated with pulmonary and cardiovascular diseases. Nonalcoholic fatty liver disease(NAFLD)has similar risk factors as these diseases, as well as obesity, hyperlipidemia, and type 2 diabetes, and it is considered a part of metabolic syndrome. In this view, many studies focus on the possible association between PM2.5 and NAFLD in recent years, including epidemiological study and experimental study, so as to investigate possible pathogenic mechanisms. With reference to the research advances in PM2.5 and NAFLD, this article reviews the association between PM2.5 and NAFLD from the aspects of lipid deposition, oxidative stress, and insulin resistance.
authors: Department of Gastroenterology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China.
authors: M
authors: M
authors: Li
authors: Y M
authors: YM
authors: Li
mesh_terms: D000397:Air Pollution / Q000009:adverse effects*; D002318:Cardiovascular Diseases; D003924:Diabetes Mellitus, Type 2; D005234:Fatty Liver / Q000378:metabolism; D006801:Humans; D007333:Insulin Resistance; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism; D024821:Metabolic Syndrome; D065626:Non-alcoholic Fatty Liver Disease / Q000378:metabolism*; D009765:Obesity; D018384:Oxidative Stress; D052638:Particulate Matter / Q000009:adverse effects*; D012307:Risk Factors
chemical_list: D052638:Particulate Matter