title: Regulation of AKT activity prevents autonomic nervous system imbalance.
abstract: Autonomic nervous system (ANS) imbalances are involved in the etiology of cancer, allergy, and collagen diseases. Previously, we hypothesized that FoxO and HSF-1 limit autonomic stress responses via negative feedback on the ANS. Here, we evaluated the role of AKT, a negative regulator of FoxO, during activation of the ANS by loneliness stress in mice. Spontaneous motility was increased during loneliness stress and decreased after release from stress. The AKT activator SC79 attenuated stress-induced spontaneous motility, whereas the AKT inhibitor API-2 prevented decreases in motility after stress release. Our results show that AKT activity regulates ANS responses to loneliness stress.
authors: Graduate School of Life and Environmental Sciences, University of Tsukuba, Japan.
authors: Tsubasa
authors: T
authors: Furuhashi
authors: Graduate School of Life and Environmental Sciences, University of Tsukuba, Japan. Electronic address: sakamoto@biol.tsukuba.ac.jp.
authors: Kazuichi
authors: K
authors: Sakamoto
mesh_terms: D000085:Acetates / Q000627:therapeutic use; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D001342:Autonomic Nervous System Diseases / Q000209:etiology* / Q000517:prevention & control*; D001578:Benzopyrans / Q000627:therapeutic use; D004195:Disease Models, Animal; D005106:Exploratory Behavior / Q000187:drug effects; D007741:Labetalol / Q000494:pharmacology; D008132:Loneliness / Q000523:psychology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D051058:Oncogene Protein v-akt / Q000378:metabolism*; D012263:Ribonucleosides / Q000494:pharmacology; D012934:Social Isolation; D013315:Stress, Psychological / Q000150:complications* / Q000209:etiology; D013997:Time Factors
chemical_list: C000614067:AKT activator SC79; D000085:Acetates; D000319:Adrenergic beta-Antagonists; D001578:Benzopyrans; D012263:Ribonucleosides; C023764:triciribine; D051058:Oncogene Protein v-akt; D007741:Labetalol
keywords: AKT; Autonomic nervous system; FoxO; Loneliness stress; Spontaneous motility