title: [Expression Level of S100A6 mRNA in MM and Its Clinical Significance].
abstract: OBJECTIVE
  To investigate the expression level of S100A6 mRNA in MM and to its clinical significance, and to evaluate its significance.
  
  
  METHODS
  The expression level of S100A6 mRNA in MM patients was determined by real time quantitative PCR(RQ-PCR), and its relationship with the clinical features and outcomes of patients was analyzed by statistic method.
  
  
  RESULTS
  S100A6 mRNA was detected in 20 MM patients. Compared with normal persons, the S100A6 mRNA expression in MM patients was higher. In different groups, the S100A6 mRNA expression in MM patients of 3 stages was higer than that in patients of 1 and 2 stages. MM patients with higher S100A6 mRNA expression had poor prognosis and higer extramedullary metastasis rate.
  
  
  CONCLUSIONS
  The high expression of S100A6 mRNA is associated with poor prognosis and may be a prognostic molecular marker of MM.
authors: Department of Hematology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing 210000, Jiangsu Province, China. E-mail: baohongyu77@163.com.
authors: Hong-Yu
authors: HY
authors: Bao
authors: Department of Hematology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing 210000, Jiangsu Province, China.
authors: Jian-Nin
authors: JN
authors: Wang
authors: Department of Hematology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing 210000, Jiangsu Province, China.
authors: Qing-Qi
authors: QQ
authors: Meng
authors: Department of Hematology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing 210000, Jiangsu Province, China.
authors: Min
authors: M
authors: Song
authors: Department of Hematology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing 210000, Jiangsu Province, China.
authors: Xing-Cai
authors: XC
authors: Fu
authors: Department of Hematology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing 210000, Jiangsu Province, China.
authors: Yan-Qiu
authors: YQ
authors: Hou
authors: Department of Hematology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing 210000, Jiangsu Province, China.
authors: Liu-Bo
authors: LB
authors: Zhang
authors: Department of Hematology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing 210000, Jiangsu Province, China.
authors: Su-Yu
authors: SY
authors: Jiang
mesh_terms: D018797:Cell Cycle Proteins; D006801:Humans; D009101:Multiple Myeloma; D012333:RNA, Messenger; D060888:Real-Time Polymerase Chain Reaction; D000075383:S100 Calcium Binding Protein A6
chemical_list: D018797:Cell Cycle Proteins; D012333:RNA, Messenger; D000075383:S100 Calcium Binding Protein A6; C055351:S100A6 protein, human