title: Sodium Nitrite Inhibits Killing of Pseudomonas aeruginosa Biofilms by Ciprofloxacin.
abstract: Sodium nitrite inhibits bacterial respiration and is in development as an antimicrobial for chronic bacterial infections associated with cystic fibrosis. The goal of the current study was to investigate the interaction between nitrite and ciprofloxacin. Using liquid culture killing assays and a biotic biofilm model, we observed that nitrite induces tolerance of ciprofloxacin.
authors: Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
authors: Anna C
authors: AC
authors: Zemke
authors: Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
authors: Brian R
authors: BR
authors: Kocak
authors: Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA jbomb@pitt.edu.
authors: Jennifer M
authors: JM
authors: Bomberger
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D018441:Biofilms / Q000187:drug effects*; D002939:Ciprofloxacin / Q000494:pharmacology*; D003550:Cystic Fibrosis / Q000382:microbiology; D008826:Microbial Sensitivity Tests; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D012977:Sodium Nitrite / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D002939:Ciprofloxacin; D012977:Sodium Nitrite
keywords: Pseudomonas aeruginosa; biofilm; ciprofloxacin; fluoroquinolone; nitrite; nitrosative stress