title: Effect of pharmacological pupil dilation on measurements and iol power calculation made using the new swept-source optical coherence tomography-based optical biometer.
abstract: OBJECTIVE
  To determine whether pupil dilation affects biometric measurements and intraocular lens (IOL) power calculation made using the new swept-source optical coherence tomography-based optical biometer (IOLMaster 700©; Carl Zeiss Meditec, Jena, Germany).
  
  
  METHODS
  Eighty-one eyes of 81 patients evaluated for cataract surgery were prospectively examined using the IOLMaster 700©before and after pupil dilation with tropicamide 1%. The measurements made were: axial length (AL), central corneal thickness (CCT), aqueous chamber depth (ACD), lens thickness (LT), mean keratometry (MK), white-to-white distance (WTW) and pupil diameter (PD). Holladay II and SRK/T formulas were used to calculate IOL power. Agreement between measurement modes (with and without dilation) was assessed through intraclass correlation coefficients (ICC) and Bland-Altman plots.
  
  
  RESULTS
  Mean patient age was 75.17±7.54 years (range: 57-92). Of the variables determined, CCT, ACD, LT and WTW varied significantly according to pupil dilation. Excellent intraobserver correlation was observed between measurements made before and after pupil dilation. Mean IOL power calculation using the Holladay 2 and SRK/T formulas were unmodified by pupil dilation.
  
  
  CONCLUSIONS
  The use of pupil dilation produces statistical yet not clinically significant differences in some IOLMaster 700©measurements. However, it does not affect mean IOL power calculation.
authors: Ophthalmology, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Calle del Prof. Martín Lagos, s/n, 28040 Madrid, Spain.
authors: P
authors: P
authors: Arriola-Villalobos
authors: Ophthalmology, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Calle del Prof. Martín Lagos, s/n, 28040 Madrid, Spain. Electronic address: jalmendral@gmail.com.
authors: J
authors: J
authors: Almendral-Gómez
authors: Instituto de Oftalmología Avanzada, 28010 Madrid, Spain.
authors: N
authors: N
authors: Garzón
authors: Ophthalmology, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Calle del Prof. Martín Lagos, s/n, 28040 Madrid, Spain.
authors: J
authors: J
authors: Ruiz-Medrano
authors: Investigative Support Unit, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), 28010 Madrid, Spain.
authors: C
authors: C
authors: Fernández-Pérez
authors: Ophthalmology, Hospital Clínico San Carlos, Departamento de Oftalmología y ORL, Facultad de Medicina, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), 28010 Madrid, Spain.
authors: J M
authors: JM
authors: Martínez-de-la-Casa
authors: Ophthalmology, Hospital Clínico San Carlos, Departamento de Oftalmología y ORL, Facultad de Medicina, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), 28010 Madrid, Spain.
authors: D
authors: D
authors: Díaz-Valle
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D058452:Axial Length, Eye / Q000033:anatomy & histology / Q000000981:diagnostic imaging* / Q000187:drug effects*; D001699:Biometry / Q000295:instrumentation / Q000379:methods; D002386:Cataract / Q000473:pathology; D004106:Dilatation / Q000009:adverse effects / Q000379:methods; D005260:Female; D006801:Humans; D007908:Lens, Crystalline / Q000033:anatomy & histology / Q000000981:diagnostic imaging / Q000187:drug effects; D007910:Lenses, Intraocular; D008297:Male; D008875:Middle Aged; D011680:Pupil / Q000187:drug effects; D041623:Tomography, Optical Coherence / Q000295:instrumentation / Q000379:methods; D014331:Tropicamide / Q000494:pharmacology*
chemical_list: D014331:Tropicamide
keywords: Biometry; Biométrie; Cataract; Cataracte; Cohérence optique swept-source; Dilatation pupillaire; IOLMaster 700(©); Pupil dilation; Swept source optical coherence tomography