title: Neuroimmunological interactions in stroke.
abstract: BACKGROUND
  Stroke is one of the leading causes of death in the world; its incidence is increasing due to increased life expectancy. However, treatment options for these patients are limited since no clinically effective drugs have been developed to date.
  
  
  METHODS
  According to clinical evidence, a number of neurochemical changes take place after stroke, including energy depletion, increased free radical synthesis, calcium accumulation, neurotransmitter imbalance, excitotoxicity, and, at a later stage, immune system activation leading to inflammation. Immune response has been shown to be a major factor in disease progression. The release of proinflammatory cytokines such as TNF increase brain damage secondary to excitotoxicity and calcium accumulation, and promote free radical synthesis and cell death through various mechanisms. On the other hand, certain anti-inflammatory cytokines, such as IL-10 and IL-4, have been shown to have a neuroprotective effect and even promote neurogenesis and synapse remodeling, which makes immune modulation a promising treatment approach.
  
  
  CONCLUSIONS
  Understanding the relationship between the immune system and the nervous system not only deepens our knowledge of stroke but also provides new diagnostic, prognostic, and therapeutic strategies that may increase the quality of life of stroke patients.
authors: Laboratorio de Biomembranas, Departamento de Farmacología, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México, México.
authors: M A
authors: MA
authors: Sotomayor-Sobrino
authors: Laboratorio de Biomembranas, Departamento de Farmacología, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México, México.
authors: A
authors: A
authors: Ochoa-Aguilar
authors: Laboratorio de Biomembranas, Departamento de Farmacología, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México, México.
authors: L A
authors: LA
authors: Méndez-Cuesta
authors: Laboratorio de Biomembranas, Departamento de Farmacología, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México, México. Electronic address: goac@unam.mx.
authors: C
authors: C
authors: Gómez-Acevedo
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000502:physiology; D018450:Disease Progression; D006801:Humans; D007249:Inflammation; D007371:Interferon-gamma; D016753:Interleukin-10; D008264:Macrophages / Q000502:physiology; D017628:Microglia / Q000502:physiology; D055495:Neurogenesis; D018696:Neuroprotective Agents; D020521:Stroke / Q000276:immunology* / Q000503:physiopathology*; D014409:Tumor Necrosis Factor-alpha
chemical_list: D018696:Neuroprotective Agents; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D007371:Interferon-gamma
keywords: Ictus; Inflamación; Inflammation; Neurogenesis; Neurogénesis; Neuroprotección; Neuroprotection; Penumbra; Stroke