title: Hepatocellular carcinoma and antidepressants: a nationwide population-based study.
abstract: Hepatocellular carcinoma (HCC) is highly prevalent in Asia. Antidepressants have been associated with increase in hepatocellular carcinoma. This is the first Asian population-based study to evaluate the association between antidepressant use and risk of HCC. Based on Taiwan's National Health Insurance Research Database, we conducted a nationwide population-based study. A total of 49,998 cases with HCC were identified and paired with 244,236 randomly selected controls. The data was analyzed via the conditional logistic regression model adjusting for several confounding factors. Use of tricyclic antidepressants (TCAs) and selective serotonin reuptake inhibitors (SSRIs) was associated with lower risk for HCC. No apparent association was found between use of other classes of antidepressants and HCC, including monoamine oxidase inhibitors (MAOIs), serotonin norepinephrine reuptake inhibitors (SNRIs), trazodone, mirtazapine and bupropion. The findings of a protective effect of TCAs and SSRIs for HCC should be interpreted with caution and warrants further research.
authors: Department of Psychiatry, Chiayi Chang Gung Memorial Hospital, Chiayi, Taiwan.|Department of Psychiatry, Chang Gung University, Taoyuan, Taiwan.
authors: Vincent Chin-Hung
authors: VC
authors: Chen
authors: Department of Psychiatry, Chang Gung University, Taoyuan, Taiwan.|Department of Child Psychiatry, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan.
authors: Chiao-Fan
authors: CF
authors: Lin
authors: Department of Psychiatry, Chang Gung University, Taoyuan, Taiwan.|Department of Child Psychiatry, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan.
authors: Yi-Hsuan
authors: YH
authors: Hsieh
authors: Department of Psychiatry, Chang Gung University, Taoyuan, Taiwan.|Department of Child Psychiatry, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan.
authors: Hsin-Yi
authors: HY
authors: Liang
authors: Department of Speech, Language Pathology and Audiology, Chung Shan Medical University, Taichung, Taiwan.
authors: Kuo-You
authors: KY
authors: Huang
authors: Department of Psychiatry, Cathay General Hospital, Taipei, Taiwan.|School of Medicine, Fu Jen Catholic University, Taipei, Taiwan.
authors: Wei-Che
authors: WC
authors: Chiu
authors: Mood Disorders Psychopharmacology Unit, University Health Network, University of Toronto, Toronto, ON, USA.
authors: Yena
authors: Y
authors: Lee
authors: Mood Disorders Psychopharmacology Unit, University Health Network, University of Toronto, Toronto, ON, USA.|Department of Psychiatry, University of Toronto, Toronto, ON, USA.
authors: Roger S
authors: RS
authors: McIntyre
authors: Department of Psychiatry, Chang Gung University, Taoyuan, Taiwan.|Department of Child Psychiatry, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan.
authors: Hsiang-Lin
authors: HL
authors: Chan
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000928:Antidepressive Agents / Q000009:adverse effects*; D006528:Carcinoma, Hepatocellular / Q000453:epidemiology* / Q000209:etiology*; D016022:Case-Control Studies; D006801:Humans; D008113:Liver Neoplasms / Q000453:epidemiology* / Q000209:etiology*; D008875:Middle Aged; D016017:Odds Ratio; D011159:Population Surveillance; D012959:Socioeconomic Factors; D013624:Taiwan / Q000453:epidemiology; D055815:Young Adult
chemical_list: D000928:Antidepressive Agents
keywords: Taiwan national insurance; antidepressants; hepatocellular carcinoma