title: An electrical bio-chip to transfer and detect electromagnetic stimulation on the cells based on vertically aligned carbon nanotubes.
abstract: A highly sensitive impedimetric bio-chip based on vertically aligned multiwall carbon nanotubes (VAMWCNTs), was applied in direct interaction with lung cancer cells. Our tool provided both inducing and monitoring the bioelectrical changes in the cells initiated by electromagnetic (EM) wave stimulation. EM wave of 940MHz frequency with different intensities was used. Here, wave ablation might accumulate electrical charge on the tips of nanotubes penetrated into cell's membrane. The charge might induce ionic exchanges into the cell and cause alterations in electrical states of the membrane. Transmembrane electrostatic/dynamic states would be strongly affected due to such exchanges. Our novel modality was that, the cells' vitality changes caused by charge inductions were electrically detected with the same nanotubes in the architecture of electrodes for impedance measurement. The responses of the sensor were confirmed by electron and florescent microscopy images as well as biological assays. In summation, our method provided an effective biochip for enhancing and detecting external EM stimulation on the cells useful for future diagnostic and therapeutic applications, such as wave-guided drug-resistance breakage.
authors: Nanoelectronic Center of Excellence, Thin Film and Nanoelectronic Lab, School of Electrical and Computer Engineering, University of Tehran, P.O. Box 14395/515, Tehran, Iran; Nano Bio Electronic Devices Lab, School of Electrical and Computer Engineering, University of Tehran, P.O. Box 14395/515, Tehran, Iran.
authors: Saeed
authors: S
authors: Rafizadeh-Tafti
authors: Center of Excellence on Applied Electromagnetic Systems, School of Electrical & Computer Engineering, University of Tehran, P.O. Box 14395-515, North Kargar Avenue, Tehran, Iran.
authors: Mohammad Hossein
authors: MH
authors: Haqiqatkhah
authors: Antenna Laboratory, School of Electrical and Computer Engineering, University of Tehran, P.O. Box 14395-515, North Kargar Avenue, Tehran, Iran.
authors: Mehrdad
authors: M
authors: Saviz
authors: Medical Nanotechnology and Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, P.O. Box 1985717443, Tehran, Iran.
authors: Mohsen
authors: M
authors: Janmaleki
authors: Center of Excellence on Applied Electromagnetic Systems, School of Electrical & Computer Engineering, University of Tehran, P.O. Box 14395-515, North Kargar Avenue, Tehran, Iran.
authors: Reza
authors: R
authors: Faraji Dana
authors: Nanoelectronic Center of Excellence, Thin Film and Nanoelectronic Lab, School of Electrical and Computer Engineering, University of Tehran, P.O. Box 14395/515, Tehran, Iran; Nano Bio Electronic Devices Lab, School of Electrical and Computer Engineering, University of Tehran, P.O. Box 14395/515, Tehran, Iran.
authors: Somayeh
authors: S
authors: Zanganeh
authors: Nanoelectronic Center of Excellence, Thin Film and Nanoelectronic Lab, School of Electrical and Computer Engineering, University of Tehran, P.O. Box 14395/515, Tehran, Iran; Nano Bio Electronic Devices Lab, School of Electrical and Computer Engineering, University of Tehran, P.O. Box 14395/515, Tehran, Iran. Electronic address: m.abdolahad@ut.ac.ir.
authors: Mohammad
authors: M
authors: Abdolahad
mesh_terms: D002460:Cell Line; D045744:Cell Line, Tumor; D002470:Cell Survival; D058266:Dielectric Spectroscopy; D004560:Electricity; D004566:Electrodes; D055590:Electromagnetic Phenomena; D005453:Fluorescence; D006801:Humans; D037742:Nanotubes, Carbon / Q000737:chemistry* / Q000648:ultrastructure
chemical_list: D037742:Nanotubes, Carbon
keywords: Biosensor; Cancer cell; Carbon nanotube; Charge accumulation; Electromagnetic wave