title: Hemostatic Efficacy of Nanofibrous Matrix in Rat Liver Injury Model.
abstract: This present study examined the hemostatic efficacy of nanofibrous matrix in a rat liver model. The nanofibrous matrix comprising gelatin and polycaprolactone was prepared by electrospinning method. Twelve animals underwent surgery and were followed-up for a month. Time taken to cease bleeding, activated partial thromboplastin time, prothrombin time, and fibrinogen concentration were measured. Histopathological examination of liver was also done of treated and control animals. All test animals showed very rapid hemostasis after application of electrospun sheet. Histopathological study showed quick recovery of liver wound in the test group as compared to the control group. The nanofibrous matrix has proven to be not only safe and effective as hemostat but has also shown its potential for liver regeneration.
authors: 1 Indian Institute of Technology Bombay, Mumbai, India.|2 Centre for Biomaterials, Cellular and Molecular Theranostics, VIT University, Vellore, India.
authors: Amit K
authors: AK
authors: Jaiswal
authors: 2 Centre for Biomaterials, Cellular and Molecular Theranostics, VIT University, Vellore, India.
authors: Hemlata
authors: H
authors: Chhabra
authors: 3 Seth G. S. Medical College and K. E. M. Hospital, Mumbai, India.
authors: Sandipan
authors: S
authors: Narwane
authors: 3 Seth G. S. Medical College and K. E. M. Hospital, Mumbai, India.
authors: Nirmala
authors: N
authors: Rege
authors: 1 Indian Institute of Technology Bombay, Mumbai, India.
authors: Jayesh R
authors: JR
authors: Bellare
mesh_terms: D000818:Animals; D016063:Blood Loss, Surgical / Q000517:prevention & control*; D004195:Disease Models, Animal; D005780:Gelatin; D006488:Hemostasis, Surgical; D008099:Liver / Q000293:injuries* / Q000601:surgery; D008297:Male; D057139:Nanofibers; D011091:Polyesters; D051381:Rats; D017208:Rats, Wistar
chemical_list: D011091:Polyesters; C016240:polycaprolactone; D005780:Gelatin
keywords: electrospinning; gelatin; hemostasis; liver injury; polycaprolactone