title: GC-MS Analysis of Bio-active Molecules Derived fromParacoccus pantotrophusFMR19 and the Antimicrobial Activity Against Bacterial Pathogens and MDROs.
abstract: The present investigation is focused on the study of chemical composition of a bioactive compound derived from a rumen isolateParacoccus pantotrophusFMR19 using GC-MS and to find out the antibacterial activity of the extracted crude bioactive compounds against multidrug resistant organisms (MDROs) and other clinical pathogens. GC-MS analysis revealed thatP. pantotrophusFMR19 produced eight major compounds that have been reported to exhibit antimicrobial property. The main components identified from hexane fraction are long chain alkanes, fatty alcohols, fatty acid methyl ester and aromatic hydrocarbons. These molecules are not only active against clinical pathogens such asSalmonellasp. andProteussp. and also effective against MDROs such as Metallo β lactamase and Pan drug resistant bacterial strains and Methicillin resistantStaphylococcus aureus.
authors: Department of Biotechnology, School of Bioengineering, SRM University, Kattankulathur, Tamilnadu 603 203 India.
authors: I
authors: I
authors: Faridha Begum
authors: Interdisciplinary Institute of Indian System of Medicine, SRM University, Kattankulathur, Tamilnadu 603 203 India.
authors: R
authors: R
authors: Mohankumar
authors: Department of Microbiology, Sri Muthukumaran Medical College and Research Institute, Chennai, Tamilnadu 600 069 India.
authors: M
authors: M
authors: Jeevan
authors: Department of Biotechnology, School of Bioengineering, SRM University, Kattankulathur, Tamilnadu 603 203 India.
authors: K
authors: K
authors: Ramani
keywords: Antibacterial activity; Bioactive compound; GC–MS; Multi-drug resistant organisms; Paracoccus pantotrophus FMR19; Rumen bacteria