title: Innate immune mediators in cancer: between defense and resistance.
abstract: Chronic inflammation in the tumor microenvironment and evasion of the antitumor effector immune response are two of the emerging hallmarks required for oncogenesis and cancer progression. The innate immune system not only plays a critical role in perpetuating these tumor-promoting hallmarks but also in developing antitumor adaptive immune responses. Thus, understanding the dual role of the innate system in cancer immunology is required for the design of combined immunotherapy strategies able to tackle established tumors. Here, we review recent advances in the understanding of the role of cell populations and soluble components of the innate immune system in cancer, with a focus on complement, the adapter molecule Stimulator of Interferon Genes, natural killer cells, myeloid cells, and B cells.
authors: Navarra Institute for Health Research (IDISNA), Pamplona, Spain.|Program of Immunology and Immunotherapy, Center for Applied Medical Research (CIMA), Pamplona, Spain.
authors: Pedro
authors: P
authors: Berraondo
authors: Navarra Institute for Health Research (IDISNA), Pamplona, Spain.|Program of Immunology and Immunotherapy, Center for Applied Medical Research (CIMA), Pamplona, Spain.
authors: Luna
authors: L
authors: Minute
authors: Navarra Institute for Health Research (IDISNA), Pamplona, Spain.|Program of Solid Tumors and Biomarkers, CIMA, Pamplona, Spain.|Deparment of Biochemistry and Genetics, School of Sciences, University of Navarra, Pamplona, Spain.
authors: Daniel
authors: D
authors: Ajona
authors: Aduro Biotech, Berkeley, CA, USA.
authors: Leticia
authors: L
authors: Corrales
authors: Navarra Institute for Health Research (IDISNA), Pamplona, Spain.|Program of Immunology and Immunotherapy, Center for Applied Medical Research (CIMA), Pamplona, Spain.
authors: Ignacio
authors: I
authors: Melero
authors: Navarra Institute for Health Research (IDISNA), Pamplona, Spain. rpio@unav.es.|Program of Solid Tumors and Biomarkers, CIMA, Pamplona, Spain. rpio@unav.es.|Deparment of Biochemistry and Genetics, School of Sciences, University of Navarra, Pamplona, Spain. rpio@unav.es.
authors: Ruben
authors: R
authors: Pio
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D019496:Cancer Vaccines / Q000276:immunology*; D003165:Complement System Proteins / Q000378:metabolism*; D006801:Humans; D007113:Immunity, Innate; D007167:Immunotherapy / Q000379:methods* / Q000639:trends; D007694:Killer Cells, Natural / Q000276:immunology*; D022423:Myeloid Cells / Q000276:immunology*; D009369:Neoplasms / Q000276:immunology* / Q000628:therapy; D019139:Tumor Escape; D059016:Tumor Microenvironment
chemical_list: D019496:Cancer Vaccines; D003165:Complement System Proteins
keywords: 
  STING
  ; B cells; complement system; dendritic cells; macrophages; myeloid-derived suppressor cells; natural killer cells