title: Percutaneous Thermal Ablation for Small-Cell Lung Cancer: Initial Experience with Ten Tumors in Nine Patients.
abstract: OBJECTIVE
  To evaluate outcomes in a small cohort of patients with local or disseminated small-cell lung cancer (SCLC) who received percutaneous thermal ablation therapy.
  
  
  METHODS
  Ten biopsy-proven SCLC tumors in 9 consecutive patients (5 men, 4 women; average age, 73.8 y ± 12.4) were retrospectively evaluated. Average tumor sizes were 1.8 cm ± 0.5 and 2.6 cm ± 1.2 among patients with local and disseminated disease, respectively. Microwave and radiofrequency ablation were each used for 5 tumors. None of the patients with local SCLC received adjuvant therapy following thermal ablation. Median follow-up duration was 16 months (range, 2-48 mo). Median and 1-year overall survival (OS) were compared for patients in the local and disseminated disease groups.
  
  
  RESULTS
  Median and 1-year OS were better among patients treated for local SCLC compared with disseminated disease (47.0 vs 5.5 mo and 3 [100%] vs 2 [40%], respectively). Pneumothorax occurred in 5 patients (55.6%), and 3 patients received successful outpatient thoracostomy tube placement. No patients were hospitalized, and there were no major complications.
  
  
  CONCLUSIONS
  This preliminary analysis suggests favorable outcomes in selected patients with local SCLC who undergo percutaneous thermal ablation without adjuvant therapy.
authors: Department of Diagnostic Imaging, The Warren Alpert Medical School of Brown University, 593 Eddy St., Providence, RI 02903. Electronic address: aaron.maxwell@lifespan.org.
authors: Aaron W P
authors: AW
authors: Maxwell
authors: Department of Diagnostic Imaging, The Warren Alpert Medical School of Brown University, 593 Eddy St., Providence, RI 02903.
authors: Terrance T
authors: TT
authors: Healey
authors: Department of Diagnostic Imaging, The Warren Alpert Medical School of Brown University, 593 Eddy St., Providence, RI 02903.
authors: Damian E
authors: DE
authors: Dupuy
mesh_terms: D055011:Ablation Techniques / Q000009:adverse effects / Q000401:mortality; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D002289:Carcinoma, Non-Small-Cell Lung / Q000401:mortality / Q000556:secondary / Q000601:surgery*; D005260:Female; D006358:Hot Temperature / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D008175:Lung Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011030:Pneumothorax / Q000209:etiology / Q000628:therapy; D000072078:Positron Emission Tomography Computed Tomography; D012189:Retrospective Studies; D016019:Survival Analysis; D013907:Thoracostomy / Q000295:instrumentation; D013997:Time Factors; D016896:Treatment Outcome; D047368:Tumor Burden