title: Efficacy and safety of aspirin combined with warfarin after acute coronary syndrome : A meta-analysis.
abstract: A comprehensive meta-analysis was performed to investigate whether the combination of high-/low-dose of aspirin and various intensities of warfarin (W) offer greater benefit than aspirin (ASA) alone. A total of 14 randomized clinical trials (RCTs) having 26,916 patients with acute coronary syndrome (ACS) met inclusion criteria. The efficacy and safety of all outcomes which included myocardial infarction (MI), all-cause death, stroke, and bleeding were calculated. The overall outcomes analysis showed there was no significant difference in the risk of MI (relative ratio [RR] 0.959, 95 % confidence interval [CI] 0.78-1.04, P = 0.308), stroke (RR 0.789, 95 % CI 0.57-1.09, P = 0.145), and all-cause death (RR 1.007, 95 % CI 0.93-1.09, P = 0.87) between the combination group and ASA group. The subgroup analysis suggested that ASA (≤100 mg/day) plus W (mean international normalized ratio [INR] 2.0-3.0) decreased the risk rate of stroke (RR 0.660, 95 % CI 0.50-0.87, P = 0.003). There was a lower risk of MI (RR 0.605, 95 % CI 0.47-0.77, P < 0.0001) as well as stroke (RR 0.594, 95 % CI 0.45-0.79, P < 0.0001) between W (INR 2.0-3.0) combined with ASA (mean dose ≥100 mg/day) and ASA. However, the risk of major bleeding (RR 1.738, 95 % CI 1.45-2.08, P < 0.0001) and minor bleeding (RR 2.767, 95 % CI 2.12-3.61, P < 0.0001) was almost doubled in the combined groups. Compared with ASA, high-dose aspirin with moderate-intensity warfarin (INR 2.0-3.0) may better reduce the risk of MI and stroke but confer an increased risk of bleeding.
authors: Department of Basic and Clinical Pharmacology, School of Pharmacy, Anhui Medical University, Hefei 230032, Anhui, China.|Department of Pharmacy, Chenjian Hospital of Hefei City, Hefei 230041, Anhui, China.
authors: P
authors: P
authors: Zhang
authors: Anhui Provincial Center for Drug Clinical Evaluation, Institute of Clinical Pharmacology and Pharmacy, Yijishan Hospital of Wannan Medical College, Wuhu 241001, Anhui, China.
authors: J
authors: J
authors: Li
authors: Department of Pharmacology and Institute of Natural Medicine, Anhui Medical University, Hefei 230032, Anhui, China.
authors: C
authors: C
authors: Wu
authors: Department of Basic and Clinical Pharmacology, School of Pharmacy, Anhui Medical University, Hefei 230032, Anhui, China. mathdrug@sina.com.
authors: X
authors: X
authors: Huang
authors: Department of Basic and Clinical Pharmacology, School of Pharmacy, Anhui Medical University, Hefei 230032, Anhui, China.
authors: L
authors: L
authors: Li
authors: Department of Basic and Clinical Pharmacology, School of Pharmacy, Anhui Medical University, Hefei 230032, Anhui, China.
authors: W
authors: W
authors: Zhang
authors: Department of Basic and Clinical Pharmacology, School of Pharmacy, Anhui Medical University, Hefei 230032, Anhui, China.
authors: C
authors: C
authors: Shen
mesh_terms: D054058:Acute Coronary Syndrome / Q000188:drug therapy* / Q000401:mortality*; D000328:Adult; D000368:Aged; D000925:Anticoagulants / Q000008:administration & dosage; D001241:Aspirin / Q000008:administration & dosage*; D015984:Causality; D015897:Comorbidity; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination / Q000706:statistics & numerical data; D064420:Drug-Related Side Effects and Adverse Reactions / Q000401:mortality; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage; D006470:Hemorrhage / Q000401:mortality* / Q000517:prevention & control; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D020521:Stroke / Q000401:mortality / Q000517:prevention & control; D015996:Survival Rate; D013923:Thromboembolism / Q000401:mortality* / Q000517:prevention & control*; D014859:Warfarin / Q000008:administration & dosage*; D055815:Young Adult
chemical_list: D000925:Anticoagulants; D005343:Fibrinolytic Agents; D014859:Warfarin; D001241:Aspirin
keywords: All-cause death; Anticoagulants; Bleeding; Myocardial infarction; Stroke