title: Understanding and Preventing the Global Increase of Inflammatory Bowel Disease.
abstract: The inflammatory bowel diseases (IBDs) are contemporary conditions of industrialized societies. The prevalence of IBD continues to increase steadily in Western countries, and newly industrialized countries have a rapidly increasing incidence. The global spread of IBD appears to associate with Westernization of diets and environments, which affects the intestinal microbiome and increases the risk of IBD in genetically susceptible individuals. It is important to increase our understanding of these events to slow progression of IBD. We present a long-term plan to develop interventions that slow or stop the global increase in the incidence of IBD.
authors: Department of Medicine, University of Calgary, Calgary, Alberta, Canada; Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada. Electronic address: ggkaplan@ucalgary.ca.
authors: Gilaad G
authors: GG
authors: Kaplan
authors: Department of Medicine and Therapeutics, Institute of Digestive Disease, State Key Laboratory of Digestive Diseases, Li Ka Shing Institute of Health Science, Chinese University of Hong Kong, Hong Kong, China. Electronic address: siewchienng@cuhk.edu.hk.
authors: Siew C
authors: SC
authors: Ng
mesh_terms: D019049:Developed Countries; D066273:Diet, Western; D064806:Dysbiosis / Q000453:epidemiology* / Q000235:genetics; D004777:Environment; D000069196:Gastrointestinal Microbiome; D059647:Gene-Environment Interaction; D020022:Genetic Predisposition to Disease; D014943:Global Health; D006801:Humans; D015994:Incidence; D000067896:Industrial Development; D015212:Inflammatory Bowel Diseases / Q000453:epidemiology* / Q000235:genetics; D015995:Prevalence
keywords: Crohn’s Disease; Gene–Environment Interaction; Microbiota; Ulcerative Colitis