title: Influence of HLA-DRB1 Alleles on the Variations of Antibody Response to Tuberculosis Serodiagnostic Antigens in Active Tuberculosis Patients.
abstract: Serology-based tests for tuberculosis (TB) diagnosis, though rapid, efficient and easily implemented, have so far shown unsatisfactory levels of sensitivity and specificity, probably due to variations of the antibody response in TB patients. The number and types of seropositive antigens vary from individual to individual. The person-to-person variations of antigen recognition may be linked to genetic polymorphisms of the human leukocyte antigen (HLA) class II alleles. In the present study, we find that there is a significant increase in the frequency of HLA-DRB1*14 (P = 2.5×10-4) among subjects with high antibody response levels compared to those with low antibody levels. HLA-DRB1*15, the most frequent allelic group in the studied active TB population, positively correlates with subjects with low antibody response levels rather than subjects with high antibody response levels (P = 0.005), which indicates the loss of relevant antigens for screening of patients with this allelic group. The potential association between HLA-DRB1 allelic group and individual antigens implies that TB diagnostic yield could be improved by the addition of antigens screened at the proteome scale in infected subjects from the HLA-DRB1*15 allelic group.
authors: Institute for Infectious Diseases and Vaccine Development, Tongji University School of Medicine, Shanghai, China.
authors: Fangbin
authors: F
authors: Zhou
authors: Institute for Infectious Diseases and Vaccine Development, Tongji University School of Medicine, Shanghai, China.
authors: Xindong
authors: X
authors: Xu
authors: Institute for Infectious Diseases and Vaccine Development, Tongji University School of Medicine, Shanghai, China.
authors: Sijia
authors: S
authors: Wu
authors: Institute for Infectious Diseases and Vaccine Development, Tongji University School of Medicine, Shanghai, China.
authors: Xiaobing
authors: X
authors: Cui
authors: Clinic and Research Center of Tuberculosis, Shanghai Key Lab of Tuberculosis, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
authors: Lin
authors: L
authors: Fan
authors: Institute for Infectious Diseases and Vaccine Development, Tongji University School of Medicine, Shanghai, China.|Department of Tropical Infectious Diseases, Second Military Medical University, Shanghai, China.
authors: Weiqing
authors: W
authors: Pan
mesh_terms: D000328:Adult; D000483:Alleles; D000907:Antibodies, Bacterial / Q000276:immunology*; D005260:Female; D059811:HLA-DRB1 Chains / Q000235:genetics* / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012698:Serologic Tests; D014376:Tuberculosis / Q000175:diagnosis* / Q000235:genetics* / Q000276:immunology
chemical_list: D000907:Antibodies, Bacterial; D059811:HLA-DRB1 Chains