title: Placental type alkaline phosphatase tissue expression in ovarian serous carcinoma.
abstract: OBJECTIVE
  To analyze the expression profile of placental type alkaline phosphatase (PLAP), cancer antigen 125 (CA125), and human epididymis protein 4 (HE4) in serous ovarian cancer and to correlate their expression with the tumor aggressiveness and progression.
  
  
  METHODS
  Retrospective study considering a tissue microarray of 82 women affected by ovarian serous cancer. Protein expression was assessed by immunohistochemistry on ovarian serous cancer tissue samples. Immunohistochemical staining was semiquantitatively evaluated as H-score.
  
  
  RESULTS
  Median H-score values were lower for PLAP, 1 (IQR 0-4) than CA125, 10 (IQR 6-12) or HE4, 8 (IQR 5-12). Even if PLAP was less expressed in the cells of serous ovarian cancer than CA125 or HE4 it was relatively more expressed in the fourth quartile of its H-score distribution among cases with low CA125 or HE4 expression. Furthermore, PLAP and HE4 high expression resulted to be significantly correlated with a better prognosis.
  
  
  CONCLUSIONS
  PLAP could be an additional marker for early detection of serous ovarian carcinoma, together with the established CA125 and HE4. In addition, PLAP expression is correlated with prognosis, giving, in this way, an additional tool for improving treatment approach.
authors: Department of Medical and Biological Sciences, DSMB, University of Udine, Udine, Italy.
authors: Maria
authors: M
authors: Orsaria
authors: Unit of Obstetrics and Gynecology, Hospital of Monfalcone (GO), Italy.|Department of Experimental Clinical and Medical Science, DISM, Clinic of Obstetrics and Gynecology, University of Udine, Udine, Italy.
authors: Ambrogio P
authors: AP
authors: Londero
authors: Department of Medical and Biological Sciences, DSMB, University of Udine, Udine, Italy.
authors: Stefania
authors: S
authors: Marzinotto
authors: Department of Medical and Biological Sciences, DSMB, University of Udine, Udine, Italy.
authors: Carla
authors: C
authors: Di Loreto
authors: Department of Experimental Clinical and Medical Science, DISM, Clinic of Obstetrics and Gynecology, University of Udine, Udine, Italy.
authors: Diego
authors: D
authors: Marchesoni
authors: Department of Medical and Biological Sciences, DSMB, University of Udine, Udine, Italy.
authors: Laura
authors: L
authors: Mariuzzi
mesh_terms: D000469:Alkaline Phosphatase / Q000096:biosynthesis*; D018394:CA-125 Antigen / Q000096:biosynthesis; D018284:Cystadenocarcinoma, Serous / Q000201:enzymology* / Q000378:metabolism / Q000473:pathology; D018450:Disease Progression; D005260:Female; D058851:GPI-Linked Proteins / Q000096:biosynthesis; D006801:Humans; D007150:Immunohistochemistry; D007527:Isoenzymes / Q000096:biosynthesis*; D008565:Membrane Proteins / Q000096:biosynthesis; D008875:Middle Aged; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000201:enzymology* / Q000378:metabolism / Q000473:pathology; D011379:Prognosis; D011506:Proteins / Q000378:metabolism; D012189:Retrospective Studies; D046888:Tissue Array Analysis; D000081102:WAP Four-Disulfide Core Domain Protein 2
chemical_list: D018394:CA-125 Antigen; D058851:GPI-Linked Proteins; D007527:Isoenzymes; C451759:MUC16 protein, human; D008565:Membrane Proteins; D011506:Proteins; D000081102:WAP Four-Disulfide Core Domain Protein 2; C569698:WFDC2 protein, human; D000469:Alkaline Phosphatase; C019839:alkaline phosphatase, placental
keywords: CA125; HE4; PLAP; ovarian serous cancer; prognostic factors; survival