title: Effects of coffee consumption on gut recovery after surgery of gynecological cancer patients: a randomized controlled trial.
abstract: BACKGROUND
  Paralytic ileus that develops after elective surgery is a common and uncomfortable complication and is considered inevitable after an intraperitoneal operation.
  
  
  OBJECTIVE
  The purpose of this study was to investigate whether coffee consumption accelerates the recovery of bowel function after complete staging surgery of gynecologic cancers.
  
  
  METHODS
  In this randomized controlled trial, 114 patients were allocated preoperatively to either postoperative coffee consumption with 3 times daily (n=58) or routine postoperative care without coffee consumption (n=56). Total abdominal hysterectomy and bilateral salpingo-oophorectomy with systematic pelvic and paraaortic lymphadenectomy were performed on all patients as part of complete staging surgery for endometrial, ovarian, cervical, or tubal cancer. The primary outcome measure was the time to the first passage of flatus after surgery. Secondary outcomes were the time to first defecation, time to first bowel movement, and time to tolerance of a solid diet.
  
  
  RESULTS
  The mean time to flatus (30.2±8.0 vs 40.2±12.1 hours; P<.001), mean time to defecation (43.1±9.4 vs 58.5±17.0 hours; P<.001), and mean time to the ability to tolerate food (3.4±1.2 vs 4.7±1.6 days; P<.001) were reduced significantly in patients who consumed coffee compared with control subjects. Mild ileus symptoms were observed in 17 patients (30.4%) in the control group compared with 6 patients (10.3%) in the coffee group (P=.01). Coffee consumption was well-tolerated and well-accepted by patients, and no intervention-related side-effects were observed.
  
  
  CONCLUSIONS
  Coffee consumption after total abdominal hysterectomy and systematic paraaortic lymphadenectomy expedites the time to bowel motility and the ability to tolerate food. This simple, cheap, and well-tolerated treatment should be added as an adjunct to the postoperative care of gynecologic oncology patients.
authors: Department of Gynecologic Oncology, Muğla Sıtkı Koçman University, Education and Research Hospital, Muğla, Turkey. Electronic address: drkemalgungorduk@gmail.com.
authors: Kemal
authors: K
authors: Güngördük
authors: Department of Gynecologic Oncology, Bakırköy Dr Sadi Konuk Education and Research Hospital, İstanbul, Turkey.
authors: İsa Aykut
authors: İA
authors: Özdemir
authors: Department of Gynecologic Oncology, Muğla Sıtkı Koçman University, Education and Research Hospital, Muğla, Turkey.
authors: Özgü
authors: Ö
authors: Güngördük
authors: Department of Gynecologic Oncology, Tepecik Education and Research Hospital, Gaziler Street, Izmir, Turkey.
authors: Varol
authors: V
authors: Gülseren
authors: Department of Gynecologic Oncology, Tepecik Education and Research Hospital, Gaziler Street, Izmir, Turkey.
authors: Mehmet
authors: M
authors: Gokçü
authors: Department of Gynecologic Oncology, Tepecik Education and Research Hospital, Gaziler Street, Izmir, Turkey.
authors: Muzaffer
authors: M
authors: Sancı
mesh_terms: D000328:Adult; D000368:Aged; D001011:Aorta; D003069:Coffee; D003672:Defecation; D005260:Female; D005414:Flatulence; D005769:Gastrointestinal Motility; D005833:Genital Neoplasms, Female / Q000601:surgery*; D013509:Gynecologic Surgical Procedures; D006801:Humans; D007044:Hysterectomy; D045823:Ileus / Q000517:prevention & control; D007418:Intestinal Pseudo-Obstruction / Q000517:prevention & control*; D008197:Lymph Node Excision; D008875:Middle Aged; D010052:Ovariectomy; D010388:Pelvis; D011182:Postoperative Care / Q000379:methods*; D011183:Postoperative Complications / Q000517:prevention & control*; D058994:Salpingectomy; D012720:Severity of Illness Index; D016037:Single-Blind Method; D013997:Time Factors
chemical_list: D003069:Coffee
keywords: coffee consumption; gynecologic cancer; ileus