title: Emerging and Future Applications of Matrix-Assisted Laser Desorption Ionization Time-of-Flight (MALDI-TOF) Mass Spectrometry in the Clinical Microbiology Laboratory: A Report of the Association for Molecular Pathology.
abstract: The performance of matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MS) for routine bacterial and yeast identification as well as direct-from-blood culture bottle identification has been thoroughly evaluated in the peer-reviewed literature. Microbiologists are now moving beyond these methods to apply MS to other areas of the diagnostic process. This review discusses the emergence of advanced matrix-assisted laser desorption ionization time-of-flight MS applications, including the identification of filamentous fungi and mycobacteria and the current and future state of antimicrobial resistance testing.
authors: Association for Molecular Pathology's Matrix-Assisted Laser Desorption Ionization Time-of-Flight Working Group, Bethesda, Maryland; Department of Pathology, Virginia Commonwealth University Medical Center, Richmond, Virginia. Electronic address: cdoern@mcvh-vcu.edu.
authors: Christopher D
authors: CD
authors: Doern
authors: Association for Molecular Pathology's Matrix-Assisted Laser Desorption Ionization Time-of-Flight Working Group, Bethesda, Maryland; Department of Pathology and Laboratory Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California.
authors: Susan M
authors: SM
authors: Butler-Wu
mesh_terms: D001419:Bacteria / Q000737:chemistry / Q000145:classification; D064790:Clinical Laboratory Services / Q000639:trends; D004352:Drug Resistance, Microbial; D006801:Humans; D007239:Infections / Q000175:diagnosis / Q000382:microbiology; D008826:Microbial Sensitivity Tests; D008828:Microbiological Techniques / Q000379:methods / Q000639:trends; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000379:methods*; D015003:Yeasts / Q000737:chemistry / Q000145:classification