title: Perinatal Brain Injury is Accompanied by Disturbances in Expression of SLC Protein Superfamily in Endotheliocytes of Hippocampal Microvessels.
abstract: The peculiarities in expression of transport proteins and the proteins implicated in the control of glycolysis by the cellular components of neurovascular units were examined in animals of different age under normal conditions and after modeled perinatal stress or hypoxic brain injury. In both cases, the specialties in expression of transport proteins in ontogenesis were revealed. The perinatal hypoxic brain injury resulted in up-regulation of MCT1, MCT4, and GLUT4 expression in endotheliocytes of hippocampal microvessels accompanied by transient elevation of HIF-1α and GSK3 expression.
authors: Research Institute of Molecular Medicine and Pathobiochemistry, V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, Russia. 441682@mail.ru.
authors: A V
authors: AV
authors: Morgun
authors: Research Institute of Molecular Medicine and Pathobiochemistry, V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, Russia.
authors: N V
authors: NV
authors: Kuvacheva
authors: Research Institute of Molecular Medicine and Pathobiochemistry, V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, Russia.
authors: E D
authors: ED
authors: Khilazheva
authors: Research Institute of Molecular Medicine and Pathobiochemistry, V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, Russia.
authors: E A
authors: EA
authors: Pozhilenkova
authors: Research Institute of Molecular Medicine and Pathobiochemistry, V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, Russia.
authors: Ya V
authors: YV
authors: Gorina
authors: Research Institute of Molecular Medicine and Pathobiochemistry, V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, Russia.
authors: N A
authors: NA
authors: Malinovskaya
authors: Research Institute of Molecular Medicine and Pathobiochemistry, V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, Russia.
authors: Yu K
authors: YK
authors: Komleva
authors: Research Institute of Molecular Medicine and Pathobiochemistry, V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, Russia.
authors: O L
authors: OL
authors: Lopatina
authors: Research Institute of Molecular Medicine and Pathobiochemistry, V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, Russia.
authors: Yu A
authors: YA
authors: Panina
authors: Research Institute of Molecular Medicine and Pathobiochemistry, V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, Russia.
authors: E D
authors: ED
authors: Gasymly
authors: Research Institute of Molecular Medicine and Pathobiochemistry, V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, Russia.
authors: A B
authors: AB
authors: Salmina
mesh_terms: D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D001010:Anxiety, Separation / Q000150:complications / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D001253:Astrocytes / Q000378:metabolism / Q000473:pathology; D001812:Blood-Brain Barrier / Q000378:metabolism / Q000473:pathology; D042783:Endothelial Cells / Q000378:metabolism / Q000473:pathology; D005260:Female; D005786:Gene Expression Regulation; D051275:Glucose Transporter Type 4 / Q000235:genetics* / Q000378:metabolism; D038362:Glycogen Synthase Kinase 3 / Q000235:genetics* / Q000378:metabolism; D006624:Hippocampus / Q000098:blood supply / Q000378:metabolism / Q000473:pathology; D006801:Humans; D000860:Hypoxia / Q000150:complications / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000235:genetics* / Q000378:metabolism; D008297:Male; D055806:Microvessels / Q000378:metabolism / Q000473:pathology; D009474:Neurons / Q000378:metabolism / Q000473:pathology; D000069336:Neurovascular Coupling; D051381:Rats; D017208:Rats, Wistar; D013315:Stress, Psychological / Q000150:complications / Q000235:genetics* / Q000378:metabolism / Q000473:pathology
chemical_list: D051275:Glucose Transporter Type 4; C497444:Hif1a protein, rat; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; C495694:Slc2a4 protein, rat; D038362:Glycogen Synthase Kinase 3
keywords: hippocampus; hypoxia; neurovascular unit; stress; transport proteins