title: Alternative complement pathway activation during invasive coronary procedures in acute myocardial infarction and stable angina pectoris.
abstract: The effect of invasive percutaneous coronary procedures on complement activation has not been elucidated. We enrolled stable angina patients with elective percutaneous coronary intervention (SA-PCI, n=24), diagnostic coronary angiography (CA, n=52) and 23 patients with ST segment elevation myocardial infarction and primary PCI (STEMI-PCI). Complement activation products (C1rC1sC1inh, C3bBbP and SC5b-9) were measured on admission, 6 and 24h after coronary procedures. The alternative pathway product, C3bBbP significantly and reversibly increased 6h after elective PCI (baseline: 7.81AU/ml, 6h: 16.09AU/ml, 24h: 4.27AU/ml, p<0.01, n=23) and diagnostic angiography (baseline: 6.13AU/ml, 6h: 12.08AU/ml, 24h: 5.4AU/ml, p<0.01, n=52). Six hour C3bBbP values correlated with post-procedural CK, creatinine level and the applied contrast material volume (r=0.41, r=0.4, r=0.3, p<0.05, respectively). In STEMI-PCI, baseline C3bBbP level was higher, compared to SA-PCI or CA patients (11.33AU/ml vs. 7.81AU/ml or 6.13AU/ml, p<0.001). Similarly, the terminal complex (SC5b-9) level was already elevated at baseline compared to SA-PCI group (3.49AU/ml vs. 1.87AU/ml, p=0.011). Complement pathway products did not increase further after primary PCI. Elective coronary procedures induced transient alternative complement pathway activation, influenced by the applied contrast volume. In STEMI, the alternative complement pathway is promptly activated during the atherothrombotic event and PCI itself had no further detectable effect.
authors: Research Group for Inflammation Biology and Immunogenomics of Hungarian Academy of Sciences and Semmelweis University, Róbert Károly krt. 44, 1134 Budapest, Hungary; Hungarian Defence Forces Medical Centre, Department of Cardiology, Róbert Károly krt. 44, 1134 Budapest, Hungary. Electronic address: horvzsofi@hotmail.com.
authors: Zsófia
authors: Z
authors: Horváth
authors: 3rd Department of Internal Medicine, Semmelweis University, Kútvölgyi út 4, 1125 Budapest, Hungary.
authors: Dorottya
authors: D
authors: Csuka
authors: Research Group for Inflammation Biology and Immunogenomics of Hungarian Academy of Sciences and Semmelweis University, Róbert Károly krt. 44, 1134 Budapest, Hungary.
authors: Katarina
authors: K
authors: Vargova
authors: Research Group for Inflammation Biology and Immunogenomics of Hungarian Academy of Sciences and Semmelweis University, Róbert Károly krt. 44, 1134 Budapest, Hungary; Hungarian Defence Forces Medical Centre, Department of Cardiology, Róbert Károly krt. 44, 1134 Budapest, Hungary.
authors: Andrea
authors: A
authors: Kovács
authors: Research Group for Inflammation Biology and Immunogenomics of Hungarian Academy of Sciences and Semmelweis University, Róbert Károly krt. 44, 1134 Budapest, Hungary; Hungarian Defence Forces Medical Centre, Department of Cardiology, Róbert Károly krt. 44, 1134 Budapest, Hungary.
authors: Sarolta
authors: S
authors: Leé
authors: 3rd Department of Internal Medicine, Semmelweis University, Kútvölgyi út 4, 1125 Budapest, Hungary.
authors: Lilian
authors: L
authors: Varga
authors: Research Group for Inflammation Biology and Immunogenomics of Hungarian Academy of Sciences and Semmelweis University, Róbert Károly krt. 44, 1134 Budapest, Hungary; Hungarian Defence Forces Medical Centre, Department of Cardiology, Róbert Károly krt. 44, 1134 Budapest, Hungary.
authors: István
authors: I
authors: Préda
authors: Research Group for Inflammation Biology and Immunogenomics of Hungarian Academy of Sciences and Semmelweis University, Róbert Károly krt. 44, 1134 Budapest, Hungary; Hungarian Defence Forces Medical Centre, Department of Cardiology, Róbert Károly krt. 44, 1134 Budapest, Hungary.
authors: Emese
authors: E
authors: Tóth Zsámboki
authors: 3rd Department of Internal Medicine, Semmelweis University, Kútvölgyi út 4, 1125 Budapest, Hungary.
authors: Zoltán
authors: Z
authors: Prohászka
authors: Research Group for Inflammation Biology and Immunogenomics of Hungarian Academy of Sciences and Semmelweis University, Róbert Károly krt. 44, 1134 Budapest, Hungary; Hungarian Defence Forces Medical Centre, Department of Cardiology, Róbert Károly krt. 44, 1134 Budapest, Hungary.
authors: Róbert Gábor
authors: RG
authors: Kiss
mesh_terms: D000208:Acute Disease; D000787:Angina Pectoris / Q000097:blood / Q000276:immunology* / Q000601:surgery*; D006348:Cardiac Surgical Procedures; D003167:Complement Activation; D003170:Complement Pathway, Alternative / Q000276:immunology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000276:immunology* / Q000601:surgery*
keywords: Alternative pathway; Complement system; Coronary artery disease; Percutaneous coronary intervention