title: [White matter hyperintensities and cognitive function in patients with late onset mania].
abstract: Bipolar disorder is characterized by affective episodes in the mania-depression spectrum. Ninety per cent of the cases have an onset before age 50. In the patients with late onset mania, white matter hyperintensities (WMH) may be seen in the MRI FLAIR sequence, although these are of uncertain significance. A case-control study was done, including patients with late onset mania attended at the National Institute of Neurology and Neurosurgery, as well as healthy controls which were paired by age, sex, and academic level. Sagital FLAIR CUBE volumetric images were obtained, and later on assessed by an expert neuroradiologist, blinded to the diagnostic category. Neuropsychological measures were obtained. The patients with late onset mania showed statistically significant deficiencies (p < 0.05) in motor programming tasks, and inhibitory control tasks, according to the Frontal Assessment Battery, as well as a significant increase in the number of WMH in the right third frontal gyrus, the left first temporal gyrus, and the left second temporal gyrus. The total number of WMH and the Frontal Assessment Battery total score showed a significant inverse correlation.
authors: Unidad de Neuropsiquiatría, Instituto Nacional de Neurología y Neurocirugía, Ciudad de México, México.
authors: Jesús
authors: J
authors: Ramírez-Bermúdez
authors: Servicio de Neuroimagen, Instituto Nacional de Neurología y Neurocirugía, Ciudad de México, México.
authors: Roger
authors: R
authors: Carrillo-Mezo
authors: Unidad de Neuropsiquiatría, Instituto Nacional de Neurología y Neurocirugía, Ciudad de México, México.
authors: Carmen
authors: C
authors: Atriano
authors: Unidad de Neuropsiquiatría, Instituto Nacional de Neurología y Neurocirugía, Ciudad de México, México.
authors: Dora
authors: D
authors: Sánchez
authors: Servicio de Neuroimagen, Instituto Nacional de Neurología y Neurocirugía, Ciudad de México, México.
authors: Óscar
authors: Ó
authors: Marrufo-Meléndez
authors: Unidad de Neuropsiquiatría, Instituto Nacional de Neurología y Neurocirugía, Ciudad de México, México.
authors: Cecilia
authors: C
authors: Berlanga
authors: Servicio de Neuroimagen, Instituto Nacional de Neurología y Neurocirugía, Ciudad de México, México.
authors: Adilia
authors: A
authors: Guadamuz
authors: Servicio de Neuroimagen, Instituto Nacional de Neurología y Neurocirugía, Ciudad de México, México.
authors: Jesús
authors: J
authors: Taboada
authors: Departamento de Neuroquímica, Instituto Nacional de Neurología y Neurocirugía, Ciudad de México, México.
authors: Camilo
authors: C
authors: Ríos
mesh_terms: D017668:Age of Onset; D000368:Aged; D001714:Bipolar Disorder / Q000000981:diagnostic imaging*; D001921:Brain / Q000000981:diagnostic imaging; D016022:Case-Control Studies; D003071:Cognition / Q000502:physiology*; D004522:Educational Status; D056344:Executive Function / Q000502:physiology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D066127:White Matter / Q000000981:diagnostic imaging*