title: In Vitro Activities of Novel Azole Compounds ATTAF-1 and ATTAF-2 against Fluconazole-Susceptible and -Resistant Isolates of Candida Species.
abstract: The in vitro activities of two novel azole compounds (aryl-1,2,4-triazol-3-ylthio analogues of fluconazole [ATTAFs]) and five comparator antifungal agents against 52 clinical Candida isolates from 5 different species were determined. The novel azole compounds had the lowest geometric mean MICs, followed by fluconazole. Moreover, combinations of these compounds with fluconazole exhibited synergistic effects against fluconazole-susceptible (22 of 23 isolates), fluconazole-susceptible dose-dependent (10 of 13 isolates), and fluconazole-resistant (1 of 16 isolates) Candida isolates.
authors: Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran.|Department of Medical Mycology and Parasitology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
authors: Hamed
authors: H
authors: Fakhim
authors: Department of Medicinal Chemistry and Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
authors: Saeed
authors: S
authors: Emami
authors: Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran.|Department of Medical Mycology and Parasitology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
authors: Afsane
authors: A
authors: Vaezi
authors: Department of Medicinal Chemistry and Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
authors: Seyedeh Mahdieh
authors: SM
authors: Hashemi
authors: Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran.|Department of Medical Mycology and Parasitology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
authors: Leila
authors: L
authors: Faeli
authors: Cellular and Molecular Research Center, Urmia University of Medical Sciences, Urmia, Iran.
authors: Kambiz
authors: K
authors: Diba
authors: Université Paris-Descartes, Faculté de Médecine, APHP, Hôpital Européen Georges Pompidou, Unité de Parasitologie-Mycologie, Service de Microbiologie, Paris, France.
authors: Eric
authors: 0000-0002-2817-3830
authors: E
authors: Dannaoui
authors: Department of Medical Mycology and Parasitology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran badalii@yahoo.com.|Invasive Fungi Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
authors: Hamid
authors: 0000-0002-6010-8414
authors: H
authors: Badali
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D001393:Azoles / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects; D025141:Drug Resistance, Fungal / Q000235:genetics; D015725:Fluconazole / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D014230:Triazoles / Q000494:pharmacology
chemical_list: D000935:Antifungal Agents; D001393:Azoles; D014230:Triazoles; D015725:Fluconazole
keywords: Candida species; In vitro susceptibility; triazole derivatives