title: The prognostic value of oxidative stress and inflammation in Chinese hemodialysis patients.
abstract: BACKGROUND
  There is limited information about oxidative stress and inflammation on the mortality of Chinese hemodialysis (HD) patients.
  
  
  METHODS
  A total of 177 HD patients and 35 healthy controls were enrolled. Their demographic information, clinical characteristics, oxidant and inflammation markers were compared. Multivariate Cox regression analysis was used to assess the risk factors for mortality.
  
  
  RESULTS
  Twenty-seven (15.3%) HD patients died during the one-year follow-up. The mean age, age ≥70 years, serum level of cardiac troponin T (cTnT), malondialdehyde (MDA) > 5 nmol/L, as well as CRP >10 mg/L and the level of interleukin (IL)-6 were significantly different between the nonsurvival and survival HD patients. Multivariate Cox's regression analysis identified age, age ≥70 years, cTnT, and IL-6 were independent predictors of mortality in HD patients.
  
  
  CONCLUSIONS
  Age, age ≥70 years, cTnT, and IL-6 were independent predictors of mortality in Chinese HD patients. Elevated IL-6 level, instead of MDA, was predictive of poor outcome in Chinese hemodialysis patients.
authors: a Department of Nephrology & Rheumatology , Shanghai Tenth People's Hospital, Tongji University School of Medicine , Shanghai , China.
authors: Zhen
authors: Z
authors: Wang
authors: a Department of Nephrology & Rheumatology , Shanghai Tenth People's Hospital, Tongji University School of Medicine , Shanghai , China.
authors: Chao
authors: C
authors: Yu
authors: a Department of Nephrology & Rheumatology , Shanghai Tenth People's Hospital, Tongji University School of Medicine , Shanghai , China.
authors: Xin-Hua
authors: XH
authors: Li
authors: a Department of Nephrology & Rheumatology , Shanghai Tenth People's Hospital, Tongji University School of Medicine , Shanghai , China.
authors: Bing-Qing
authors: BQ
authors: Deng
mesh_terms: D000367:Age Factors; D000368:Aged; D015415:Biomarkers / Q000032:analysis / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000209:etiology; D015850:Interleukin-6 / Q000097:blood*; D007676:Kidney Failure, Chronic / Q000175:diagnosis / Q000378:metabolism / Q000401:mortality / Q000628:therapy; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D018384:Oxidative Stress; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D006435:Renal Dialysis / Q000009:adverse effects / Q000401:mortality; D012307:Risk Factors; D020107:Troponin T / Q000097:blood*
chemical_list: D015415:Biomarkers; D015850:Interleukin-6; D020107:Troponin T; D008315:Malondialdehyde; D002097:C-Reactive Protein
keywords: End-stage renal disease; hemodialysis; inflammation; mortality; oxidative stress