title: Metabolomic Biomarkers in the Progression to Type 1 Diabetes.
abstract: Metabolomics is the snapshot of all detectable metabolites and lipids in biological materials and has potential in reflecting genetic and environmental factors contributing to the development of complex diseases, such as type 1 diabetes. The progression to seroconversion to development of type 1 diabetes has been studied using this technique, although in relatively small cohorts and at limited time points. Overall, three observations have been consistently reported; phospholipids at birth are lower in children developing type 1 diabetes early in childhood, methionine levels are lower in children at seroconversion, and triglycerides are increased at seroconversion and associated to microbiome diversity, indicating an association between the metabolome and microbiome in type 1 diabetes progression.
authors: Department of Pediatrics, Herlev University Hospital, Herlev Ringvej 75, DK-2730, Herlev, Denmark. aove0012@regionh.dk.
authors: Anne Julie
authors: AJ
authors: Overgaard
authors: Department of Pediatrics, Herlev University Hospital, Herlev Ringvej 75, DK-2730, Herlev, Denmark.
authors: Simranjeet
authors: S
authors: Kaur
authors: Department of Pediatrics, Herlev University Hospital, Herlev Ringvej 75, DK-2730, Herlev, Denmark.|Institute of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, DK-2200, Copenhagen N, Denmark.
authors: Flemming
authors: F
authors: Pociot
mesh_terms: D015551:Autoimmunity; D015415:Biomarkers / Q000032:analysis; D003922:Diabetes Mellitus, Type 1 / Q000209:etiology* / Q000378:metabolism; D018450:Disease Progression; D006801:Humans; D055432:Metabolomics; D008715:Methionine / Q000097:blood; D014280:Triglycerides / Q000097:blood
chemical_list: D015415:Biomarkers; D014280:Triglycerides; D008715:Methionine
keywords: Autoimmunity; Lipids; Metabolites; Metabolomics; Type 1 diabetes