title: Phytochemicals Against Advanced Glycation End Products (AGEs) and the Receptor System.
abstract: Reducing sugars can react non-enzymatically with amino groups of proteins and lipids to form irreversibly cross-linked macroprotein derivatives called as advanced glycation end products (AGEs). Cross-linking modification of extracellular matrix proteins by AGEs deteriorate their tertiary structural integrity and function, contributing to aging-related organ damage and diabetes-associated complications, such as cardiovascular disease (CVD). Moreover, engagement of receptor for AGEs, RAGE with the ligands evoke oxidative stress generation and inflammatory, thrombotic and fibrotic reactions in various kinds of tissues, further exacerbating the deleterious effects of AGEs on multiple organ systems. So the AGE-RAGE axis is a novel therapeutic target for numerous devastating disorders. Several observational studies have shown the association of dietary consumption of fruits and vegetables with the reduced risk of CVD in a general population. Although beneficial effects of fruits and vegetables against CVD could mainly be ascribed to its anti-oxidative properties, blockade of the AGERAGE axis by phytochemicals may also contribute to cardiovascular event protection. Therefore, in this review, we focus on 4 phytochemicals (quercetin, sulforaphane, iridoids, and curcumin) and summarize their effects on AGE formation as well as RAGE-mediated signaling pathway in various cell types and organs, including endothelial cells, vessels, and heart.
authors: Department of Pathophysiology and Therapeutics of Diabetic Vascular Complications, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Japan.
authors: Sho-Ichi
authors: SI
authors: Yamagishi
authors: Department of Pathophysiology and Therapeutics of Diabetic Vascular Complications, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Japan.
authors: Takanori
authors: T
authors: Matsui
authors: Department of Pathophysiology and Therapeutics of Diabetic Vascular Complications, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Japan.
authors: Yuji
authors: Y
authors: Ishibashi
authors: Morinda Worldwide Inc., Tokyo 160- 0023, Japan.
authors: Fumiyuki
authors: F
authors: Isami
authors: Morinda Worldwide Inc., Tokyo 160- 0023, Japan.
authors: Yumi
authors: Y
authors: Abe
authors: Department of Chemistry, Kurume University School of Medicine, Kurume 830-0011, Japan.
authors: Tatsuya
authors: T
authors: Sakaguchi
authors: Department of Chemistry, Kurume University School of Medicine, Kurume 830-0011, Japan.
authors: Yuichiro
authors: Y
authors: Higashimoto
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000188:drug therapy* / Q000378:metabolism; D017127:Glycation End Products, Advanced / Q000037:antagonists & inhibitors* / Q000378:metabolism; D006801:Humans; D064209:Phytochemicals / Q000494:pharmacology*; D000067759:Receptor for Advanced Glycation End Products / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D017127:Glycation End Products, Advanced; D064209:Phytochemicals; D000067759:Receptor for Advanced Glycation End Products
keywords: AGEs; RAGE; cardiovascular disease; oxidative stress; phytochemicals