title: A Comparative Study of Sociability in Angelman, Cornelia de Lange, Fragile X, Down and Rubinstein Taybi Syndromes and Autism Spectrum Disorder.
abstract: Few comparative studies have evaluated the heterogeneity of sociability across a range of neurodevelopmental disorders. The Sociability Questionnaire for People with Intellectual Disability (SQID) was completed by caregivers of individuals with Cornelia de Lange (n = 98), Angelman (n = 66), Fragile X (n = 142), Down (n = 117) and Rubinstein Taybi (n = 88) syndromes and autism spectrum disorder (ASD; n = 107). Between groups and age-band (<12yrs; 12-18yrs; >18yrs) comparisons of SQID scores were conducted. Rates of behaviors indicative of selective mutism were also examined. Fragile X syndrome achieved the lowest SQID scores. Cornelia de Lange, ASD, and Fragile X groups scored significantly lower than Angelman, Down and Rubinstein Taybi groups. Selective mutism characteristics were highest in Cornelia de Lange (40%) followed by Fragile X (17.8%) and ASD (18.2%). Age-band differences were identified in Cornelia de Lange and Down syndrome.
authors: Joanna Moss, Cerebra Centre for Neurodevelopmental Disorders, University of Birmingham, and Institute of Cognitive Neuroscience, University College London; Lisa Nelson, Laurie Powis, Jane Waite, Caroline Richards, and Chris Oliver, Cerebra Centre for Neurodevelopmental Disorders, University of Birmingham.
authors: Joanna
authors: J
authors: Moss
authors: Lisa
authors: L
authors: Nelson
authors: Laurie
authors: L
authors: Powis
authors: Jane
authors: J
authors: Waite
authors: Caroline
authors: C
authors: Richards
authors: Joanna Moss, Cerebra Centre for Neurodevelopmental Disorders, University of Birmingham, and Institute of Cognitive Neuroscience, University College London; Lisa Nelson, Laurie Powis, Jane Waite, Caroline Richards, and Chris Oliver, Cerebra Centre for Neurodevelopmental Disorders, University of Birmingham.
authors: Chris
authors: C
authors: Oliver
mesh_terms: D000293:Adolescent; D017204:Angelman Syndrome / Q000523:psychology*; D000067877:Autism Spectrum Disorder / Q000523:psychology*; D002648:Child; D003635:De Lange Syndrome / Q000523:psychology*; D004314:Down Syndrome / Q000523:psychology*; D005260:Female; D005600:Fragile X Syndrome / Q000523:psychology*; D006801:Humans; D008297:Male; D012415:Rubinstein-Taybi Syndrome / Q000523:psychology*; D066107:Social Skills; D011795:Surveys and Questionnaires
keywords: autism spectrum disorder; behavioral phenotypes; genetic syndromes; sociability; social anxiety