title: REAC technology modifies pathological neuroinflammation and motor behaviour in an Alzheimer's disease mouse model.
abstract: The search for new therapeutic approaches to Alzheimer disease (AD) is a major goal in medicine and society, also due to the impressive economic and social costs of this disease. In this scenario, biotechnologies play an important role. Here, it is demonstrated that the Radio Electric Asymmetric Conveyer (REAC), an innovative technology platform for neuro- and bio-modulation, used according to the neuro-regenerative protocol (RGN-N), significantly increases astroglial reaction around the amyloid plaques in an AD mouse model, as evaluated by GFAP-immunoreactivity, and reduces microglia-associated neuroinflammation markers, as evaluated by Iba1-immunoreactivity and mRNA expression level of inflammatory cytokines TREM. IL1beta, iNOS and MRC1 were not affected neither by the genotype or by REAC RGN-N treatment. Also observed was an increase in locomotion in treated animals. The study was performed in 24-month-old male Tg2576 mice and age-matching wild-type animals, tested for Y-maze, contextual fear conditioning and locomotion immediately after the end of a specific REAC treatment administered for 15 hours/day for 15 days. These results demonstrated that REAC RGN-N treatment modifies pathological neuroinflammation, and mitigates part of the complex motor behaviour alterations observed in very old Tg2576 mice.
authors: IRET Foundation, Ozzano Emilia, Italy.
authors: Luca
authors: L
authors: Lorenzini
authors: Department of Veterinary Medical Science, University of Bologna, Italy.
authors: Alessandro
authors: A
authors: Giuliani
authors: Department of Veterinary Medical Science, University of Bologna, Italy.
authors: Sandra
authors: S
authors: Sivilia
authors: Health Science and Technologies Interdepartmental Center for Industrial Research (HST-ICIR). University of Bologna, Italy.|Department of Pharmacy and Biotechnology, University of Bologna, Italy.
authors: Vito Antonio
authors: Baldassarro
authors: Health Science and Technologies Interdepartmental Center for Industrial Research (HST-ICIR). University of Bologna, Italy.
authors: Mercedes
authors: M
authors: Fernandez
authors: Department of Regenerative Medicine and Neuro Psycho Physical Optimization, Rinaldi Fontani Institute, Florence, Italy.|Research Department, Rinaldi Fontani Foundation, Florence, Italy.
authors: Matteo
authors: M
authors: Lotti Margotti
authors: IRET Foundation, Ozzano Emilia, Italy.|Department of Veterinary Medical Science, University of Bologna, Italy.|Health Science and Technologies Interdepartmental Center for Industrial Research (HST-ICIR). University of Bologna, Italy.
authors: Luciana
authors: L
authors: Giardino
authors: Department of Regenerative Medicine and Neuro Psycho Physical Optimization, Rinaldi Fontani Institute, Florence, Italy.|Research Department, Rinaldi Fontani Foundation, Florence, Italy.
authors: Vania
authors: V
authors: Fontani
authors: Department of Regenerative Medicine and Neuro Psycho Physical Optimization, Rinaldi Fontani Institute, Florence, Italy.|Research Department, Rinaldi Fontani Foundation, Florence, Italy.
authors: Salvatore
authors: S
authors: Rinaldi
authors: IRET Foundation, Ozzano Emilia, Italy.|Health Science and Technologies Interdepartmental Center for Industrial Research (HST-ICIR). University of Bologna, Italy.|Department of Pharmacy and Biotechnology, University of Bologna, Italy.
authors: Laura
authors: Calzà
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism / Q000473:pathology*; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism; D000818:Animals; D016207:Cytokines / Q000378:metabolism; D004195:Disease Models, Animal; D007249:Inflammation / Q000378:metabolism / Q000473:pathology*; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D017628:Microglia / Q000378:metabolism / Q000473:pathology; D009043:Motor Activity / Q000502:physiology*; D052247:Nitric Oxide Synthase Type II / Q000378:metabolism; D058225:Plaque, Amyloid / Q000378:metabolism / Q000473:pathology; D012333:RNA, Messenger / Q000378:metabolism
chemical_list: D016564:Amyloid beta-Protein Precursor; D016207:Cytokines; D012333:RNA, Messenger; D052247:Nitric Oxide Synthase Type II