title: Critical Analysis of the Melanogenic Pathway in Insects and Higher Animals.
abstract: Animals synthesize melanin pigments for the coloration of their skin and use it for their protection from harmful solar radiation. Insects use melanins even more ingeniously than mammals and employ them for exoskeletal pigmentation, cuticular hardening, wound healing and innate immune responses. In this review, we discuss the biochemistry of melanogenesis process occurring in higher animals and insects. A special attention is given to number of aspects that are not previously brought to light: (1) the molecular mechanism of dopachrome conversion that leads to the production of two different dihydroxyindoles; (2) the role of catecholamine derivatives other than dopa in melanin production in animals; (3) the critical parts played by various biosynthetic enzymes associated with insect melanogenesis; and (4) the presence of a number of important gaps in both melanogenic and sclerotinogenic pathways. Additionally, importance of the melanogenic process in insect physiology especially in the sclerotization of their exoskeleton, wound healing reactions and innate immune responses is highlighted. The comparative biochemistry of melanization with sclerotization is also discussed.
authors: Department of Biology, University of Massachusetts Boston, Boston, MA 02125, USA. Manickam.sugumaran@umb.edu.
authors: Manickam
authors: M
authors: Sugumaran
authors: Department of Biology, University of Massachusetts Boston, Boston, MA 02125, USA. Haning.barek001@umb.edu.
authors: Hanine
authors: H
authors: Barek
mesh_terms: D060105:Animal Shells / Q000378:metabolism*; D000818:Animals; D002395:Catecholamines / Q000737:chemistry*; D007113:Immunity, Innate / Q000276:immunology; D045563:Indolequinones / Q000737:chemistry; D007211:Indoles; D007313:Insecta / Q000378:metabolism*; D008543:Melanins / Q000096:biosynthesis* / Q000378:metabolism; D012880:Skin Pigmentation / Q000502:physiology*
chemical_list: D002395:Catecholamines; D045563:Indolequinones; D007211:Indoles; D008543:Melanins; C461099:dihydroxyindole-melanin; C001123:dopachrome
keywords: dopa; dopachrome tautomerase; dopamine; eumelanin; laccase; melanogenesis; phenoloxidase; sclerotization; tyrosinase