title: In vivo Patterns of Tau Pathology, Amyloid-β Burden, and Neuronal Dysfunction in Clinical Variants of Alzheimer's Disease.
abstract: The clinical heterogeneity of Alzheimer's disease is not reflected in the rather diffuse cortical deposition of amyloid-β. We assessed the relationship between clinical symptoms, in vivo tau pathology, amyloid distribution, and hypometabolism in variants of Alzheimer's disease using novel multimodal PET imaging techniques. Tau pathology was primarily observed in brain regions related to clinical symptoms and overlapped with areas of hypometabolism. In contrast, amyloid-β deposition was diffusely distributed over the entire cortex. Tau PET imaging may thus serve as a valuable biomarker for the localization of neuronal injury in vivo and may help to validate atypical subtypes of Alzheimer's disease.
authors: Department of Neurology, University Hospital Cologne, Cologne, Germany.|Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM-3), Research Center Jülich, Jülich, Germany.
authors: Julian
authors: J
authors: Dronse
authors: Department of Psychiatry and Psychotherapy, University Hospital Bonn, Bonn, Germany.|German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
authors: Klaus
authors: K
authors: Fliessbach
authors: Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM-3), Research Center Jülich, Jülich, Germany.|Multimodal Neuroimaging Group, Department of Nuclear Medicine, University Hospital Cologne, Cologne, Germany.
authors: Gérard N
authors: GN
authors: Bischof
authors: Department of Neurology, University Hospital Cologne, Cologne, Germany.|Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM-3), Research Center Jülich, Jülich, Germany.
authors: Boris
authors: B
authors: von Reutern
authors: German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.|Department of Neurology, University Hospital Bonn, Bonn, Germany.
authors: Jennifer
authors: J
authors: Faber
authors: Multimodal Neuroimaging Group, Department of Nuclear Medicine, University Hospital Cologne, Cologne, Germany.
authors: Jochen
authors: J
authors: Hammes
authors: Multimodal Neuroimaging Group, Department of Nuclear Medicine, University Hospital Cologne, Cologne, Germany.
authors: Georg
authors: G
authors: Kuhnert
authors: Nuclear Chemistry, Institute of Neuroscience and Medicine (INM-5), Research Center Jülich, Jülich, Germany.|Institute of Radiochemistry and Experimental Molecular Imaging, University Hospital Cologne, Cologne, Germany.
authors: Bernd
authors: B
authors: Neumaier
authors: Department of Neurology, University Hospital Cologne, Cologne, Germany.|Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM-3), Research Center Jülich, Jülich, Germany.
authors: Oezguer A
authors: OA
authors: Onur
authors: Department of Neurology, University Hospital Cologne, Cologne, Germany.|Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM-3), Research Center Jülich, Jülich, Germany.
authors: Juraj
authors: J
authors: Kukolja
authors: Department of Neurology, University Hospital Cologne, Cologne, Germany.|Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM-3), Research Center Jülich, Jülich, Germany.|German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.|Multimodal Neuroimaging Group, Department of Nuclear Medicine, University Hospital Cologne, Cologne, Germany.
authors: Thilo
authors: T
authors: van Eimeren
authors: German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.|Department of Psychiatry, University Hospital Cologne, Cologne, Germany.
authors: Frank
authors: F
authors: Jessen
authors: Department of Neurology, University Hospital Cologne, Cologne, Germany.|Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM-3), Research Center Jülich, Jülich, Germany.
authors: Gereon R
authors: GR
authors: Fink
authors: German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.|Department of Neurology, University Hospital Bonn, Bonn, Germany.
authors: Thomas
authors: T
authors: Klockgether
authors: German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.|Multimodal Neuroimaging Group, Department of Nuclear Medicine, University Hospital Cologne, Cologne, Germany.
authors: Alexander
authors: A
authors: Drzezga
mesh_terms: D000544:Alzheimer Disease / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology*; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D001284:Atrophy / Q000209:etiology; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology*; D002243:Carbolines / Q000378:metabolism; D003072:Cognition Disorders / Q000000981:diagnostic imaging / Q000209:etiology; D066276:Corticomedial Nuclear Complex / Q000473:pathology; D056344:Executive Function; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000378:metabolism; D006801:Humans; D007806:Language Disorders / Q000209:etiology; D008297:Male; D009483:Neuropsychological Tests; D049268:Positron-Emission Tomography; D016875:tau Proteins / Q000378:metabolism*
chemical_list: D016229:Amyloid beta-Peptides; D002243:Carbolines; D016875:tau Proteins; D019788:Fluorodeoxyglucose F18; C000591008:7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indole
keywords: 18F-AV-1451; 18F-FDG; Alzheimer’s disease; Pittsburghcompound B; T-807; amyloid; molecular imaging; multimodal imaging; positron-emission tomography; tau protein