title: The association between vitamin D receptor polymorphisms and serum 25-hydroxyvitamin D levels with ulcerative colitis in Chinese Han population.
abstract: There is now growing evidence suggesting that Vitamin D is playing a critical role in modulating the innate and adaptive immune responses. Several polymorphisms have been identified in the vitamin D receptor (VDR) gene but their association with ulcerative colitis (UC) susceptibility remained controversy. In the current study, we examined the association between VDR polymorphisms and serum level of 25-hydroxyvitamin D [25(OH)D] with UC in Chinese Han population. Polymorphisms of FokI (rs2228570)/BsmI (rs1544410)/ApaI (rs7975232)/TaqI (rs731236) in the VDR gene were assessed in a case-control study comprising 404 UC patients and 612 controls. Moreover, 25(OH)D levels were measured by electro-chemiluminescence immunoassay in 75 UC patients and 120 controls. Our results suggested that BsmI polymorphism frequency was significantly lower in UC patients (P=0.028), and the frequency of AAC haplotype formed by BsmI, ApaI and TaqI was also significantly lower in UC patients (P=0.012). Moreover, FokI polymorphism was more frequently observed in patients with mild and moderate UC as compared to those with severe UC (P=0.001, P<0.001, respectively). Average 25(OH)D level was lower in UC patients than in controls (19.3±6.8 vs. 21.8±7.3ng/mL, P=0.017), and was significantly correlated with hemoglobin (β=0.49, P<0.001), C-reactive protein (β=-0.36, P<0.001), severity of UC (β=-0.21, P=0.025) and FokI polymorphism (β=-0.20, P=0.031) in UC patients. Interestingly, there was a significant correlation between FokI polymorphism and vitamin D deficiency (<20ng/mL) in UC patients (P=0.006). Together, these results supported that VDR polymorphisms and 25(OH)D level were significantly correlated with UC risk and severity in Chinese Han population.
authors: Department of Gastroenterology, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
authors: Shu-Zi
authors: SZ
authors: Zheng
authors: Department of Gastroenterology, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
authors: Da-Guan
authors: DG
authors: Zhang
authors: Department of Gastroenterology, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
authors: Hao
authors: H
authors: Wu
authors: Department of Gastroenterology, the Wenzhou Central Hospital, Wenzhou, China.
authors: Li-Jia
authors: LJ
authors: Jiang
authors: Department of Gastroenterology, the Wenzhou Central Hospital, Wenzhou, China.
authors: Jie
authors: J
authors: Jin
authors: Department of Gastroenterology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
authors: Xiu-Qing
authors: XQ
authors: Lin
authors: Department of Gastroenterology, Wenzhou Renmin Hospital, Wenzhou, China.
authors: Ran
authors: R
authors: Ding
authors: Department of Gastroenterology, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. Electronic address: wzjiangyi@yeah.net.
authors: Yi
authors: Y
authors: Jiang
mesh_terms: D000328:Adult; D000483:Alleles; D044466:Asian People / Q000706:statistics & numerical data; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D003093:Colitis, Ulcerative / Q000208:ethnology / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D018167:Receptors, Calcitriol / Q000235:genetics*; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood / Q000235:genetics
chemical_list: D018167:Receptors, Calcitriol; D014807:Vitamin D; C104450:25-hydroxyvitamin D