title: The emerging roles of MicroRNAs in autism spectrum disorders.
abstract: Autism spectrum disorders (ASD) are heritable neurodevelopmental conditions characterized by impairment in social interaction and communication and restricted, repetitive, stereotyped patterns of behavior. ASD likely involve deregulation of multiple genes related to brain function and development. MicroRNAs (miRNAs) are post-transcriptional regulators that play key roles in brain development, synapse formation and fine-tuning of genes underlying synaptic plasticity and memory formation. Here, we review recent studies providing genetic and molecular links between miRNA deregulation and ASD pathophysiology. These findings highlight the potential of miRNAs as both biomarkers and therapeutic tools in ASD.
authors: INSERM UMR 1163, Laboratory of Molecular and Pathophysiological Bases of Cognitive Disorders, Imagine Institute, Necker-Enfants Malades Hospital, 24 Boulevard du Montparnasse, 75015 Paris, France; Paris Descartes-Sorbonne Paris Cité University, 12 Rue de l'École de Médecine, 75006 Paris, France. Electronic address: julien.fregeac@inserm.fr.
authors: Julien
authors: J
authors: Fregeac
authors: INSERM UMR 1163, Laboratory of Molecular and Pathophysiological Bases of Cognitive Disorders, Imagine Institute, Necker-Enfants Malades Hospital, 24 Boulevard du Montparnasse, 75015 Paris, France; Paris Descartes-Sorbonne Paris Cité University, 12 Rue de l'École de Médecine, 75006 Paris, France. Electronic address: laurence.colleaux@inserm.fr.
authors: Laurence
authors: L
authors: Colleaux
authors: INSERM UMR 1163, Laboratory of Molecular and Pathophysiological Bases of Cognitive Disorders, Imagine Institute, Necker-Enfants Malades Hospital, 24 Boulevard du Montparnasse, 75015 Paris, France; Paris Descartes-Sorbonne Paris Cité University, 12 Rue de l'École de Médecine, 75006 Paris, France. Electronic address: lam-son.nguyen@inserm.fr.
authors: Lam Son
authors: LS
authors: Nguyen
mesh_terms: D000067877:Autism Spectrum Disorder; D015415:Biomarkers; D006801:Humans; D035683:MicroRNAs; D009473:Neuronal Plasticity
chemical_list: D015415:Biomarkers; D035683:MicroRNAs
keywords: Autism spectrum disorders; Biomarkers; Epigenetic; microRNA