title: The integrin adhesome network at a glance.
abstract: The adhesion nexus is the site at which integrin receptors bridge intracellular cytoskeletal and extracellular matrix networks. The connection between integrins and the cytoskeleton is mediated by a dynamic integrin adhesion complex (IAC), the components of which transduce chemical and mechanical signals to control a multitude of cellular functions. In this Cell Science at a Glance article and the accompanying poster, we integrate the consensus adhesome, a set of 60 proteins that have been most commonly identified in isolated IAC proteomes, with the literature-curated adhesome, a theoretical network that has been assembled through scholarly analysis of proteins that localise to IACs. The resulting IAC network, which comprises four broad signalling and actin-bridging axes, provides a platform for future studies of the regulation and function of the adhesion nexus in health and disease.
authors: Wellcome Trust Centre for Cell-Matrix Research, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PT, UK.
authors: Edward R
authors: 0000-0001-9530-9585
authors: ER
authors: Horton
authors: Wellcome Trust Centre for Cell-Matrix Research, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PT, UK.
authors: Jonathan D
authors: 0000-0002-8953-7079
authors: JD
authors: Humphries
authors: Wellcome Trust Centre for Cell-Matrix Research, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PT, UK.
authors: Jenny
authors: J
authors: James
authors: Wellcome Trust Centre for Cell-Matrix Research, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PT, UK.
authors: Matthew C
authors: MC
authors: Jones
authors: Wellcome Trust Centre for Cell-Matrix Research, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PT, UK.
authors: Janet A
authors: JA
authors: Askari
authors: Wellcome Trust Centre for Cell-Matrix Research, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PT, UK martin.humphries@manchester.ac.uk.
authors: Martin J
authors: 0000-0002-4331-6967
authors: MJ
authors: Humphries
mesh_terms: D000818:Animals; D002448:Cell Adhesion; D004194:Disease; D006801:Humans; D016023:Integrins / Q000378:metabolism*; D020543:Proteome / Q000378:metabolism*
chemical_list: D016023:Integrins; D020543:Proteome
keywords: Adhesion; Adhesome; Cytoskeleton; Integrin; Integrin adhesion complex