title: Impact of sodium lauryl sulfate in oral liquids on e-tongue measurements.
abstract: During development of oral liquid medicines taste assessment is often required to evaluate taste and taste masking. Electronic tongue analysis can provide taste assessment of medicinal products but should only be conducted with medicines that interact with the instrument without damaging the sensor membranes or interfering with their electrical output so that robust data is generated. To explore the impact of a substance deemed unsuitable for electronic tongue analysis the influence of the anionic surfactant sodium lauryl sulfate (SLS), on the performance of the electronic tongue was conducted using electronic tongues equipped with self-developed PVC based sensors. The results showed a significant impact of SLS on all applied sensor types and an alteration of the sensor's sensitivity. Nevertheless, concentration dependent sensor responses could still be obtained and the sensor performance was not impacted negatively. Assessment of unsuitable substances should therefore be evaluated prior to performing electronic tongue analysis so that their impact is understood fully.
authors: Heinrich-Heine-University Duesseldorf, Institute of Pharmaceutics and Biopharmaceutics, Universitaetsstrasse 1, 40225 Duesseldorf, Germany. Electronic address: immohr@hhu.de.
authors: Laura Isabell
authors: LI
authors: Immohr
authors: Novartis Pharma AG, Technical Research & Development, 4056 Basel, Switzerland. Electronic address: roy.turner@novartis.com.
authors: Roy
authors: R
authors: Turner
authors: Heinrich-Heine-University Duesseldorf, Institute of Pharmaceutics and Biopharmaceutics, Universitaetsstrasse 1, 40225 Duesseldorf, Germany; University of Applied Sciences Ostwestfalen-Lippe, Life Sciences Technologies, Georg-Weerth-Strasse 20, 32756 Detmold, Germany. Electronic address: miriam.pein-hackelbusch@hs-owl.de.
authors: Miriam
authors: M
authors: Pein-Hackelbusch
mesh_terms: D000284:Administration, Oral; D015374:Biosensing Techniques / Q000379:methods; D002626:Chemistry, Pharmaceutical / Q000379:methods; D055615:Electrical Equipment and Supplies; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D012967:Sodium Dodecyl Sulfate / Q000737:chemistry*; D013649:Taste / Q000187:drug effects*; D055697:Taste Perception / Q000187:drug effects; D013678:Technology, Pharmaceutical / Q000379:methods; D014059:Tongue / Q000187:drug effects*
chemical_list: D004364:Pharmaceutical Preparations; D012967:Sodium Dodecyl Sulfate
keywords: Electronic-tongue sensors; Methylparaben (PubChem CID: 7456); Performance test; Quinine hydrochloride dihydrate (PubChem CID: 16211283); Sensitivity; Sodium lauryl sulfate (PubChem CID: 3423265)