title: Epidemiological and etiological characteristics of herpangina and hand foot mouth diseases in Jiangsu, China, 2013-2014.
abstract: Herpangina (HA) and hand, foot, and mouth disease (HFMD) are common infectious diseases caused by human enteroviruses and frequently occurr in young children. Previous published studies have mainly focused on HFMD, while the HA epidemiological and etiological characteristics in mainland China have not been described. From June, 2013 to March, 2014, HA and HFMD patients were monitored in participants from clinical trial of EV-A71 vaccine conducted during 2012-2013. A total of 95 HA patients and 161 HFMD patients were defined. Enteroviruses of HA samples were differentiated into 17 serotypes (EV-A71, CV-A16, CV-A24, E6, CV-B5, CV-A22, CV-A6, CV-A10, CV-B3, E9, CV-A9, CV-B4, CV-B2, E1, E7, E21 and CV-A20), the most common serotypes were EV-A71(10/95,10.5%), CV-A16(4/95,4.2%) and CV-A24(4/95,4.2%); while enteroviruses detected from HFMD samples were classfied into 21 serotypes ( EV-A71, CV-A16, CV-A10, CV-A6, E6, CV-B3, CV-B5, CV-A9, E9, CV-B2, CV-B4, E3, E11, E15, E16, CV-A1, EV-A69, E5, CA22, CA24 and EV99), the most common serotypes were EV-A71(28/161,17.4%), CV-A16(7/161,4.4%) and CV-A10(5/161,3.1%). The first HA epidemic peak occurred in summer and a second smaller peak occurred in January. In HA patients, the body temperature (P < 0.0001) and the incidence of fever (P < 0.05) were significant higher than those in HFMD patients. Between HA and HFMD patients infected with EV-A71, no significant differences were found in age, sex, circulating season, and the viral genome diversity. In summary, we firstly reported the epidemiological and etiological characteristics of HA in mainland China. Developing a multivalent vaccine will be helpful for the control of the HA/HFMD epidemic.
authors: a National Institute for Food and Drug Control , Beijing , China.
authors: Xin
authors: X
authors: Yao
authors: a National Institute for Food and Drug Control , Beijing , China.
authors: Lian-Lian
authors: LL
authors: Bian
authors: b Beijing Vigoo Biological , Beijing , China.
authors: Wei-Wei
authors: WW
authors: Lu
authors: c Jiangsu Provincial Center for Disease Control and Prevention , Nanjing , China.
authors: Jing-Xin
authors: JX
authors: Li
authors: a National Institute for Food and Drug Control , Beijing , China.
authors: Qun-Ying
authors: QY
authors: Mao
authors: a National Institute for Food and Drug Control , Beijing , China.
authors: Yi-Ping
authors: YP
authors: Wang
authors: a National Institute for Food and Drug Control , Beijing , China.
authors: Fan
authors: F
authors: Gao
authors: a National Institute for Food and Drug Control , Beijing , China.
authors: Xing
authors: X
authors: Wu
authors: a National Institute for Food and Drug Control , Beijing , China.
authors: Qiang
authors: Q
authors: Ye
authors: b Beijing Vigoo Biological , Beijing , China.
authors: Xiu-Ling
authors: XL
authors: Li
authors: c Jiangsu Provincial Center for Disease Control and Prevention , Nanjing , China.
authors: Feng-Cai
authors: FC
authors: Zhu
authors: a National Institute for Food and Drug Control , Beijing , China.
authors: Zhenglun
authors: Z
authors: Liang
mesh_terms: D017677:Age Distribution; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D004770:Enterovirus / Q000145:classification* / Q000302:isolation & purification*; D005260:Female; D006232:Hand, Foot and Mouth Disease / Q000453:epidemiology* / Q000209:etiology*; D006557:Herpangina / Q000453:epidemiology* / Q000209:etiology*; D006801:Humans; D007223:Infant; D008297:Male; D012621:Seasons; D065288:Serogroup; D017678:Sex Distribution
keywords: and mouth disease; clinical manifestations; enterovirus spectrum; foot; hand; herpangina; human enteroviruses