title: Naturally Occurring Cinnamic Acid Sugar Ester Derivatives.
abstract: Cinnamic acid sugar ester derivatives (CASEDs) are a class of natural product with one or several phenylacrylic moieties linked with the non-anomeric carbon of a glycosyl skeleton part through ester bonds. Their notable anti-depressant and brains protective activities have made them a topic of great interest over the past several decades. In particular the compound 3',6-disinapoylsucrose, the index component of Yuanzhi (a well-known Traditional Chinese Medicine or TCM), presents antidepressant effects at a molecular level, and has become a hotspot of research on new lead drug compounds. Several other similar cinnamic acid sugar ester derivatives are reported in traditional medicine as compounds to calm the nerves and display anti-depression and neuroprotective activity. Interestingly, more than one third of CASEDs are distributed in the familyPolygalaceae. This overview discusses the isolation of cinnamic acid sugar ester derivatives from plants, together with a systematic discussion of their distribution, chemical structures and properties and pharmacological activities, with the hope of providing references for natural product researchers and draw attention to these interesting compounds.
authors: School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China. tianyuxin1216@163.com.
authors: Yuxin
authors: Y
authors: Tian
authors: School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China. liuweirui2012@126.com.
authors: Weirui
authors: W
authors: Liu
authors: School of Basic Medicine, Beijing University of Chinese Medicine, Beijing 100102, China. luyi780707@hotmail.com.
authors: Yi
authors: Y
authors: Lu
authors: School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China. 18739908461@163.com.
authors: Yan
authors: Y
authors: Wang
authors: School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China. chenxiaofly1209@126.com.
authors: Xiaoyi
authors: X
authors: Chen
authors: School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China. shaojuanbai@163.com.
authors: Shaojuan
authors: S
authors: Bai
authors: School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China. zhaoyicheng0824@163.com.
authors: Yicheng
authors: Y
authors: Zhao
authors: School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China. 13580771726@163.com.
authors: Ting
authors: T
authors: He
authors: Beijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University, Beijing 100191, China. Fengxue@buu.edu.cn.
authors: Fengxue
authors: F
authors: Lao
authors: Beijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University, Beijing 100191, China. Yinghui@buu.edu.cn.
authors: Yinghui
authors: Y
authors: Shang
authors: Beijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University, Beijing 100191, China. guoyu@buu.edu.cn.
authors: Yu
authors: Y
authors: Guo
authors: School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China. shegaimei@126.com.
authors: Gaimei
authors: G
authors: She
mesh_terms: D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000494:pharmacology; D000928:Antidepressive Agents / Q000737:chemistry* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D000975:Antioxidants / Q000737:chemistry* / Q000494:pharmacology; D002934:Cinnamates / Q000737:chemistry*; D004952:Esters / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D008516:Medicine, Chinese Traditional; D018696:Neuroprotective Agents / Q000737:chemistry* / Q000494:pharmacology; D064209:Phytochemicals / Q000737:chemistry / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry; D011134:Polysaccharides / Q000737:chemistry
chemical_list: D000893:Anti-Inflammatory Agents; D000928:Antidepressive Agents; D000970:Antineoplastic Agents; D000975:Antioxidants; D002934:Cinnamates; D004952:Esters; D018696:Neuroprotective Agents; D064209:Phytochemicals; D010936:Plant Extracts; D011134:Polysaccharides; C029010:cinnamic acid
keywords: cinnamic acid sugar ester derivatives; pharmacological activity; phytochemistry; traditional Chinese medicine