title: Does aspirin use reduce the risk for cancer?
abstract: Recently, studies have reported that aspirin has chemopreventive properties. In this study, we used the Taiwan NHI database, which covers a population of 23 million (99.99%) Taiwanese from 2001 to 2011. This was a case-control study which identified 601,733 patients using ICD-9-CM codes who were diagnosed with cancer. Each case with 4 eligible controls was matched for age, sex, and index date and adjusted for confounding factors. The observed overall cancer risk (adjusted OR (AOR), 0.95; 95% CI 0.94 to 0.96) reduced with aspirin use, specifically, colorectal (AOR, 0.97; 95% CI 0.94 to 0.99) and digestive system (AOR, 0.96; 95% CI 0.94 to 0.98) cancers. Findings from the Asian population would contribute to the discussion on aspirin's safety profile.
authors: Masters Program in Global Health and Development Department, College of Public Health, Taipei Medical University, Taipei, Taiwan.|International Center for Health Information Technology, Taipei, Taiwan.
authors: Usman
authors: U
authors: Iqbal
authors: International Center for Health Information Technology, Taipei, Taiwan.|Institute of Biomedical Informatics, National Yang Ming University, Taipei, Taiwan.
authors: Hsuan-Chia
authors: HC
authors: Yang
authors: International Center for Health Information Technology, Taipei, Taiwan.|School of Health Care Administration, College of Management, Taipei Medical University, Taipei, Taiwan.
authors: Wen-Shan
authors: WS
authors: Jian
authors: College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.|City of Hope, Duarte, California, USA.
authors: Yun
authors: Y
authors: Yen
authors: International Center for Health Information Technology, Taipei, Taiwan.|College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.|Department of Dermatology, Wan Fang Hospital, Taipei, Taiwan.
authors: Yu-Chuan Jack
authors: YJ
authors: Li
mesh_terms: D000328:Adult; D001241:Aspirin / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000453:epidemiology*; D012307:Risk Factors; D013624:Taiwan / Q000453:epidemiology
chemical_list: D001241:Aspirin
keywords: Aspirin; Cancer; Carcinogenesis; Drug-Related Side Effects and Adverse Reactions; Drugs, Investigational