title: Cooling down the bath salts: Carvedilol attenuation of methylone and mephedrone mediated hyperthermia.
abstract: The use of the synthetic cathinones ("bath salts"), methylone and mephedrone, has been associated with the development of life-threatening hyperthermia. To date, no direct pharmacological intervention to mitigate the hyperthermia induced by synthetic cathinones has been identified. Here, we investigated the effects of the non-selective α1and β adrenergic receptor antagonist carvedilol (5mg/kg ip) on established hyperthermia mediated by methylone and mephedrone (30mg/kg sc) in Sprague-Dawley rats. Methylone and mephedrone induced a hyperthermic response that peaked 60min post treatment. The administration of carvedilol 30min after methylone or mephedrone significantly attenuated these hyperthermic responses. Analysis of the Temperature Area Under the Curve (TAUC) demonstrated carvedilol significantly reduced the TAUC associated with methylone or mephedrone alone. The present study provides the first direct pharmacological intervention for the treatment of synthetic cathinone induced hyperthermia.
authors: The Ohio Attorney General's Center for the Future of Forensic Science, Bowling Green State University, Bowling Green, OH 43403, USA.
authors: Luke C
authors: LC
authors: Zona
authors: The Ohio Attorney General's Center for the Future of Forensic Science, Bowling Green State University, Bowling Green, OH 43403, USA.
authors: Gregory G
authors: GG
authors: Grecco
authors: The Ohio Attorney General's Center for the Future of Forensic Science, Bowling Green State University, Bowling Green, OH 43403, USA. Electronic address: jesprag@bgsu.edu.
authors: Jon E
authors: JE
authors: Sprague
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D002227:Carbazoles / Q000494:pharmacology*; D000077261:Carvedilol; D000697:Central Nervous System Stimulants / Q000037:antagonists & inhibitors / Q000633:toxicity*; D015198:Designer Drugs / Q000737:chemistry*; D005334:Fever / Q000139:chemically induced* / Q000517:prevention & control*; D008297:Male; D008694:Methamphetamine / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors / Q000633:toxicity; D011412:Propanolamines / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000319:Adrenergic beta-Antagonists; D002227:Carbazoles; D000697:Central Nervous System Stimulants; D015198:Designer Drugs; D011412:Propanolamines; D000077261:Carvedilol; D008694:Methamphetamine; C548233:mephedrone; C400939:methylone
keywords: Bath salts; Hyperthermia; Synthetic cathinones