title: In the Middle of a Chain Interaction.
abstract: In this issue of Molecular Cell, Fu et al. (2016) present a detailed structural analysis of death-inducing signaling complex (DISC) assembly and regulation through flexible caspase-8 interactions with cFLIPL, cFLIPS, and the viral inhibitor MC159, thereby identifying novel apoptosis control mechanisms.
authors: Department of Physiology and Medical Physics and Centre for Systems Medicine, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin 2, Ireland.
authors: Sinéad
authors: S
authors: Kinsella
authors: Department of Physiology and Medical Physics and Centre for Systems Medicine, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin 2, Ireland. Electronic address: prehn@rcsi.ie.
authors: Jochen H M
authors: JH
authors: Prehn
mesh_terms: D017209:Apoptosis / Q000187:drug effects*; D053181:Caspase 8; D006801:Humans; D053221:TNF-Related Apoptosis-Inducing Ligand
chemical_list: D053221:TNF-Related Apoptosis-Inducing Ligand; D053181:Caspase 8