title: Quinoline Alkaloids Isolated from Choisya Aztec-Pearl and Their Contribution to the Overall Antinociceptive Activity of This Plant.
abstract: Choisya 'Aztec-Pearl', a hybrid of Choisya ternata and Choisya dumosa var. arizonica, had the antinociceptive activity in the ethanol extract (EECA) of its leaves evaluated. Two quinoline alkaloids, anhydroevoxine (A) and choisyine (C), isolated from these leaves were also tested. The results obtained pointed out to a very high antinociceptive activity measured by the hot plate model for EECA (at doses of 10, 30 and 100 mg/kg) as well as for A and C (at doses of 1, 3 and 10 mg/kg). The magnitude of the activity was two-fold higher than the one observed for the morphine treated animals for the higher doses of extracts/compounds (30, 100 mg/kg and 3, 10 mg/kg respectively). The mechanism of action for this activity was also investigated and it seems that for EECA as well as A and C, the opiate system plays an important role. Results have also shown that the nitric oxide (NO) system also play a pivotal role in the case of EECA and A while for C it seems that the cholinergic system have some involvement. The acute toxicity was evaluated for EECA with results showing no important toxic effect.
authors: Universidade Federal do Rio de Janeiro, Instituto de Ciências Biomédicas, Laboratório de Farmacologia da Dor e da Inflamação, Rio de Janeiro, Brazil.
authors: Patricia Ribeiro
authors: PR
authors: de Carvalho
authors: School of Pharmacy and Pharmaceutical Sciences, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
authors: Denise Ricoy
authors: DR
authors: Ropero
authors: Universidade Federal do Rio de Janeiro, Instituto de Ciências Biomédicas, Laboratório de Farmacologia da Dor e da Inflamação, Rio de Janeiro, Brazil.
authors: Mariana Martins
authors: MM
authors: Pinheiro
authors: Universidade Federal do Rio de Janeiro, Instituto de Ciências Biomédicas, Laboratório de Farmacologia da Dor e da Inflamação, Rio de Janeiro, Brazil.
authors: Patricia Dias
authors: PD
authors: Fernandes
authors: School of Pharmacy and Pharmaceutical Sciences, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
authors: Fabio
authors: http://orcid.org/0000-0001-5531-1787
authors: F
authors: Boylan
mesh_terms: D000470:Alkaloids / Q000009:adverse effects / Q000302:isolation & purification* / Q000494:pharmacology; D000700:Analgesics / Q000009:adverse effects / Q000494:pharmacology*; D000818:Animals; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000009:adverse effects / Q000494:pharmacology*; D011804:Quinolines / Q000009:adverse effects / Q000302:isolation & purification* / Q000494:pharmacology; D027821:Rutaceae / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D000700:Analgesics; D010936:Plant Extracts; D011804:Quinolines