title: Antimicrobial metal-based thiophene derived compounds.
abstract: A novel series of thiophene derived Schiff bases and their transition metal- [Co(II), Cu(II), Zn(II), Ni(II)] based compounds are reported. The Schiff bases act as tridentate ligands toward metal ions via azomethine-N, deprotonated-N of ammine substituents and S-atom of thienyl moiety. The synthesized ligands along with their metal complexes were screened for their in vitro antibacterial activity against six bacterial pathogens (Escherichia coli, Shigella flexneri, Pseudomonas aeruginosa, Salmonella typhi, Staphylococcus aureus and Bacillus subtilis) and for antifungal activity against six fungal pathogens (Trichophytonlongifusus, Candida albicans, Aspergillus flavus, Microsporum canis, Fusarium solani and Candida glabrata). The results of antimicrobial studies revealed the free ligands to possess potential activity which significantly increased upon chelation.
authors: a Institute of Chemical Sciences , Bahauddin Zakariya University , Multan , Pakistan.
authors: Shakeela
authors: S
authors: Yasmeen
authors: b Department of Chemistry , University of Gujrat , Gujrat , Pakistan.
authors: Sajjad Hussain
authors: SH
authors: Sumrra
authors: c School of Science & Engineering , Teesside University , Middlesbrough , UK.
authors: Muhammad Safwan
authors: MS
authors: Akram
authors: d Department of Chemistry , University of Sargodha , Bhakkar Campus, Sargodha, Pakistan.
authors: Zahid H
authors: ZH
authors: Chohan
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000145:classification / Q000187:drug effects; D066241:Carbon-13 Magnetic Resonance Spectroscopy; D005658:Fungi / Q000145:classification / Q000187:drug effects; D008670:Metals / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D066244:Proton Magnetic Resonance Spectroscopy; D013876:Thiophenes / Q000737:chemistry*
chemical_list: D000890:Anti-Infective Agents; D008670:Metals; D013876:Thiophenes
keywords: Acetyl thiophene; antimicrobial activity; diammines; metal(II) chelates; tridentate ligands