title: Protective Effects of Hydrogen against Low-Dose Long-Term Radiation-Induced Damage to the Behavioral Performances, Hematopoietic System, Genital System, and Splenic Lymphocytes in Mice.
abstract: Molecular hydrogen (H2) has been previously reported playing an important role in ameliorating damage caused by acute radiation. In this study, we investigated the effects of H2on the alterations induced by low-dose long-term radiation (LDLTR). All the mice in hydrogen-treated or radiation-only groups received 0.1 Gy, 0.5 Gy, 1.0 Gy, and 2.0 Gy whole-body gamma radiation, respectively. After the last time of radiation exposure, all the mice were employed for the determination of the body mass (BM) observation, forced swim test (FST), the open field test (OFT), the chromosome aberration (CA), the peripheral blood cells parameters analysis, the sperm abnormality (SA), the lymphocyte transformation test (LTT), and the histopathological studies. And significant differences between the treatment group and the radiation-only groups were observed, showing that H2could diminish the detriment induced by LDLTR and suggesting the protective efficacy of H2in multiple systems in mice against LDLTR.
authors: Department of Radiation Medicine, Faculty of Naval Medicine, Second Military Medical University, No. 800, Xiangyin Road, Shanghai 200433, China.
authors: Jiaming
authors: 0000-0001-9898-237X
authors: J
authors: Guo
authors: Department of Radiation Medicine, Faculty of Naval Medicine, Second Military Medical University, No. 800, Xiangyin Road, Shanghai 200433, China.
authors: Deyun
authors: 0000-0002-8306-0329
authors: D
authors: Zhao
authors: Department of Radiation Medicine, Faculty of Naval Medicine, Second Military Medical University, No. 800, Xiangyin Road, Shanghai 200433, China.
authors: Xiao
authors: X
authors: Lei
authors: Department of Radiation Medicine, Faculty of Naval Medicine, Second Military Medical University, No. 800, Xiangyin Road, Shanghai 200433, China.
authors: Hainan
authors: H
authors: Zhao
authors: Department of Radiation Medicine, Faculty of Naval Medicine, Second Military Medical University, No. 800, Xiangyin Road, Shanghai 200433, China.
authors: Yanyong
authors: 0000-0002-6882-5274
authors: Y
authors: Yang
authors: Department of Radiation Medicine, Faculty of Naval Medicine, Second Military Medical University, No. 800, Xiangyin Road, Shanghai 200433, China.
authors: Pei
authors: 0000-0002-3297-899X
authors: P
authors: Zhang
authors: Department of Radiation Medicine, Faculty of Naval Medicine, Second Military Medical University, No. 800, Xiangyin Road, Shanghai 200433, China.
authors: Pengfei
authors: P
authors: Liu
authors: Department of Radiation Medicine, Faculty of Naval Medicine, Second Military Medical University, No. 800, Xiangyin Road, Shanghai 200433, China.
authors: Yang
authors: Y
authors: Xu
authors: Department of Radiation Medicine, Faculty of Naval Medicine, Second Military Medical University, No. 800, Xiangyin Road, Shanghai 200433, China.
authors: Meizhou
authors: 0000-0002-0288-0406
authors: M
authors: Zhu
authors: Department of Radiation Medicine, Faculty of Naval Medicine, Second Military Medical University, No. 800, Xiangyin Road, Shanghai 200433, China.
authors: Hu
authors: 0000-0002-3560-386X
authors: H
authors: Liu
authors: Department of Radiation Medicine, Faculty of Naval Medicine, Second Military Medical University, No. 800, Xiangyin Road, Shanghai 200433, China.
authors: Yuanyuan
authors: Y
authors: Chen
authors: Department of Radiation Medicine, Faculty of Naval Medicine, Second Military Medical University, No. 800, Xiangyin Road, Shanghai 200433, China.
authors: Yunhai
authors: Y
authors: Chuai
authors: Department of Radiation Medicine, Faculty of Naval Medicine, Second Military Medical University, No. 800, Xiangyin Road, Shanghai 200433, China.
authors: Bailong
authors: 0000-0001-5942-2396
authors: B
authors: Li
authors: Department of Radiation Medicine, Faculty of Naval Medicine, Second Military Medical University, No. 800, Xiangyin Road, Shanghai 200433, China.
authors: Fu
authors: 0000-0002-9792-8248
authors: F
authors: Gao
authors: Department of Radiation Medicine, Faculty of Naval Medicine, Second Military Medical University, No. 800, Xiangyin Road, Shanghai 200433, China.
authors: Jianming
authors: 0000-0003-4907-2067
authors: J
authors: Cai
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects / Q000528:radiation effects; D015992:Body Mass Index; D002869:Chromosome Aberrations / Q000187:drug effects / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D006413:Hematopoietic System / Q000187:drug effects / Q000528:radiation effects*; D006859:Hydrogen / Q000494:pharmacology*; D008214:Lymphocytes / Q000187:drug effects / Q000528:radiation effects*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D011833:Radiation Injuries, Experimental / Q000517:prevention & control*; D011897:Random Allocation; D013094:Spermatozoa / Q000187:drug effects / Q000528:radiation effects*; D013154:Spleen / Q000166:cytology / Q000187:drug effects / Q000528:radiation effects*; D014916:Whole-Body Irradiation
chemical_list: D006859:Hydrogen