title: Fabrication of High Contact-Density, Flat-Interface Nerve Electrodes for Recording and Stimulation Applications.
abstract: Many attempts have been made to manufacture multi-contact nerve cuff electrodes that are safe, robust and reliable for long term neuroprosthetic applications. This protocol describes a fabrication technique of a modified cylindrical nerve cuff electrode to meet these criteria. Minimum computer-aided design and manufacturing (CAD and CAM) skills are necessary to consistently produce cuffs with high precision (contact placement 0.51 ± 0.04 mm) and various cuff sizes. The precision in spatially distributing the contacts and the ability to retain a predefined geometry accomplished with this design are two criteria essential to optimize the cuff's interface for selective recording and stimulation. The presented design also maximizes the flexibility in the longitudinal direction while maintaining sufficient rigidity in the transverse direction to reshape the nerve by using materials with different elasticities. The expansion of the cuff's cross sectional area as a result of increasing the pressure inside the cuff was observed to be 25% at 67 mm Hg. This test demonstrates the flexibility of the cuff and its response to nerve swelling post-implant. The stability of the contacts' interface and recording quality were also examined with contacts' impedance and signal-to-noise ratio metrics from a chronically implanted cuff (7.5 months), and observed to be 2.55 ± 0.25 kΩ and 5.10 ± 0.81 dB respectively.
authors: Neural Engineering Center, Case Western Reserve University; Jordan University of Science and Technology.
authors: Yazan M
authors: YM
authors: Dweiri
authors: Advanced Platform Technology Center, U.S. Department of Veterans Affairs.
authors: Matthew A
authors: MA
authors: Stone
authors: Neural Engineering Center, Case Western Reserve University.
authors: Dustin J
authors: DJ
authors: Tyler
authors: Neural Engineering Center, Case Western Reserve University.
authors: Grant A
authors: GA
authors: McCallum
authors: Neural Engineering Center, Case Western Reserve University; DXD6@CASE.EDU.
authors: Dominique M
authors: DM
authors: Durand
mesh_terms: D017076:Computer-Aided Design; D004558:Electric Stimulation; D004566:Electrodes; D004567:Electrodes, Implanted; D004867:Equipment Design; D010525:Peripheral Nerves