title: Polycystic ovary syndrome and endometrial hyperplasia: an overview of the role of bariatric surgery in female fertility.
abstract: One of the most effective methods to tackle obesity and its related comorbidities is bariatric surgery. Polycystic ovary syndrome (PCOS) and endometrial hyperplasia (EH), which are associated with increased risk of endometrial carcinoma, have been identified as potentially new indications for bariatric surgery. PCOS is the most common endocrine disorder in women in the reproductive age and is associated with several components of the metabolic syndrome such as obesity, insulin resistance and hypertension. EH is a pre-cancerous condition which arises in the presence of chronic exposure to estrogen unopposed by progesterone such as both in PCOS and obesity. The main bariatric procedures are Roux-en-Y gastric bypass, laparoscopic sleeve gastrectomy and laparoscopic adjustable gastric banding. These procedures are well established and when correctly selected and performed by experienced bariatric surgeons, they can achieve significant weight loss and remission of obesity related co-morbidities. Studies have shown that bariatric surgery can play an important role in the management of patients with PCOS and improve fertility. Similarly, bariatric surgery has a positive effect on endometrial hyperplasia, making surgically induced weight loss a potentially attractive option for endometrial cancer prevention and treatment. Obesity has an adverse impact on spontaneous pregnancy, assisted reproduction methods and feto-maternal outcomes. After bariatric surgery obese women with subfertility can achieve spontaneous pregnancy. However, while bariatric surgery reduces the risk of pre-eclampsia and gestational diabetes, there is an increased risk of small for gestational age and possible increased risk of stillborn or neonatal death. In this article we will review the evidence regarding the use of bariatric surgery as a treatment modality in patients with PCOS and EH. We also provide an overview of the common bariatric procedures.
authors: Bariatric Unit, Department of General Surgery, Birmingham Heartlands Hospital, Heart of England NHS Foundation Trust, Birmingham, UK. Electronic address: vcharalambakis@gmail.com.
authors: Vasileios
authors: V
authors: Charalampakis
authors: Institute of Metabolism and Systems Research (IMSR), School of Medicine, University of Birmingham, Birmingham, UK; Department of Diabetes and Endocrinology, Birmingham Heartlands Hospital, Birmingham, UK.
authors: Abd A
authors: AA
authors: Tahrani
authors: Department of Diabetes and Endocrinology, Birmingham Heartlands Hospital, Birmingham, UK.
authors: Ahmed
authors: A
authors: Helmy
authors: Institute of Metabolism and Systems Research (IMSR), School of Medicine, University of Birmingham, Birmingham, UK; Birmingham Women's Hospital, Birmingham, UK.
authors: Janesh K
authors: JK
authors: Gupta
authors: Bariatric Unit, Department of General Surgery, Birmingham Heartlands Hospital, Heart of England NHS Foundation Trust, Birmingham, UK.
authors: Rishi
authors: R
authors: Singhal
mesh_terms: D000328:Adult; D050110:Bariatric Surgery; D003131:Combined Modality Therapy; D015897:Comorbidity; D004714:Endometrial Hyperplasia / Q000453:epidemiology / Q000503:physiopathology / Q000517:prevention & control*; D019317:Evidence-Based Medicine; D005260:Female; D000070497:Healthy Lifestyle; D006801:Humans; D007247:Infertility, Female / Q000209:etiology / Q000517:prevention & control* / Q000628:therapy; D009765:Obesity / Q000453:epidemiology / Q000503:physiopathology / Q000601:surgery / Q000628:therapy; D009767:Obesity, Morbid / Q000453:epidemiology / Q000503:physiopathology / Q000601:surgery* / Q000628:therapy; D011085:Polycystic Ovary Syndrome / Q000453:epidemiology / Q000503:physiopathology / Q000517:prevention & control*; D011247:Pregnancy; D027724:Reproductive Techniques, Assisted; D015431:Weight Loss
keywords: Bariatric surgery; Endometrial hyperplasia; Obesity; Polycystic ovary syndrome