title: Deep Vein Thrombosis: An Independent Poor Prognosis Factor of Advanced Pancreatic Adenocarcinoma.
abstract: Pancreatic adenocarcinoma (PA) is frequently associated with venous thromboembolic events (VTEs). Although the prognostic value of VTEs remains controversial, these events can darken the prognosis. In contrast, because they necessitate anticoagulant therapy, some authors found that VTEs improved the prognosis. Indeed, anticoagulants could have an anti-tumor action. Therefore, we evaluated the prognostic value of VTEs in patients with locally advanced or metastatic PA.
  
  
  
  This retrospective study included all patients followed in a medical oncology Department. The prognostic value of tumor parameters, initial patients' characteristics and VTEs were subjected to univariate and multivariate analyses.
  
  
  
  Based on 142 patients, analyses revealed independent pejorative prognostic value of: VTEs (hazard ratio (HR)=1.49 (95% confidence interval (CI)=1.03-2.15); p=0.03), interval between PA diagnosis and metastases occurrence (HR=0.97 (95% CI=0.94-0.99), p=0.02) and ≥1 metastatic sites (HR=1.82 (95% CI=1.076-3.087), p=0.02).
  
  
  
  VTEs are an independent factor of poor prognosis in patients with advanced PA.
authors: Department of Internal Medicine, University Hospital, Lille, France.
authors: Marc
authors: M
authors: Lambert
authors: Department of Medical Oncology, University Hospital, Lille, France.
authors: Anne
authors: A
authors: Ploquin
authors: Department of Medical Oncology, University Hospital, Lille, France.
authors: Lydie
authors: L
authors: Declerck
authors: CERIM, EA2694, UDSL, Department of Biostatistics, University Hospital, Lille, France.
authors: Alain
authors: A
authors: Duhamel
authors: Department of Medical Oncology, University Hospital, Lille, France.
authors: Samira
authors: S
authors: Makhloufi
authors: Department of Medical Oncology, University Hospital, Lille, France.
authors: Anthony
authors: A
authors: Turpin
authors: Service Department of Digestive Surgery and Transplantation, University Hospital, Lille, France.
authors: Stéphanie
authors: S
authors: Truant
authors: Department of Medical Oncology, University Hospital, Lille, France mohamed.hebbar@chru-lille.fr.
authors: Mohamed
authors: M
authors: Hebbar
mesh_terms: D000230:Adenocarcinoma / Q000150:complications* / Q000473:pathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000150:complications* / Q000473:pathology; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate; D020246:Venous Thrombosis / Q000209:etiology*
keywords: Pancreatic adenocarcinoma; deep vein thrombosis; metastasis; prognosis