title: One-Pot Reactions for Modular Synthesis of Polysubstituted and Fused Pyridines.
abstract: A 2-fluoro-1,3-dicarbonyl-initiated one-pot Michael addition/[5 + 1] annulation/dehydrofluorinative aromatization reaction sequence is introduced for regioselective synthesis of di-, tri-, tetra-, and pentasubstituted pyridines as well as fused pyridines. This simple and modular synthesis is performed using readily available starting materials and under transition-metal catalyst-free conditions.
authors: School of Chemical Engineering, Nanjing University of Science and Technology , Nanjing 210094, P. R. China.
authors: Zhidong
authors: Z
authors: Song
authors: Department of Chemistry, University of Massachusetts Boston , Boston, Massachusetts 02125, United States.
authors: Xin
authors: X
authors: Huang
authors: School of Chemical Engineering, Nanjing University of Science and Technology , Nanjing 210094, P. R. China.
authors: Wenbin
authors: W
authors: Yi
authors: Department of Chemistry, University of Massachusetts Boston , Boston, Massachusetts 02125, United States.
authors: Wei
authors: W
authors: Zhang