title: Therapeutic Potential of Fatty Acid Amide Hydrolase, Monoacylglycerol Lipase, and N-Acylethanolamine Acid Amidase Inhibitors.
abstract: Fatty acid ethanolamides (FAEs) and endocannabinoids (ECs) have been shown to alleviate pain and inflammation, regulate motility and appetite, and produce anticancer, anxiolytic, and neuroprotective efficacies via cannabinoid receptor type 1 (CB1) or type 2 (CB2) or via peroxisome proliferator-activated receptor α (PPAR-α) stimulation. FAEs and ECs are synthesized by a series of endogenous enzymes, including N-acylphosphatidylethanolaminephospholipase D (NAPE-PLD), diacylglycerol lipase (DAGL), or phospholipase C (PLC), and their metabolism is mediated by several metabolic enzymes, including fatty acid amide hydrolase (FAAH), monoacylglycerol lipase (MAGL), N-acylethanolamine acid amidase (NAAA), or cyclooxygenase 2 (COX-2). Over the past decades, increasing the concentration of FAEs and ECs through the inhibition of degrading enzymes has been considered to be a viable therapeutic approach to enhance their antinociceptive and anti-inflammatory effects, as well as to protect the nervous system.
authors: Université de Lille, Inserm, CHU Lille, U995, LIRIC, Lille Inflammation Research International Center, F-59000 Lille, France.
authors: Wei
authors: W
authors: Tuo
authors: Université de Lille, Inserm, CHU Lille, U995, LIRIC, Lille Inflammation Research International Center, F-59000 Lille, France.
authors: Natascha
authors: N
authors: Leleu-Chavain
authors: Department of Chemistry, School of Life Sciences, University of Sussex , Brighton BN1 9QJ, U.K.
authors: John
authors: J
authors: Spencer
authors: Department of Chemistry, School of Life Sciences, University of Sussex , Brighton BN1 9QJ, U.K.
authors: Supojjanee
authors: S
authors: Sansook
authors: Université de Lille, Inserm, CHU Lille, U995, LIRIC, Lille Inflammation Research International Center, F-59000 Lille, France.
authors: Régis
authors: R
authors: Millet
authors: Université de Lille, Inserm, CHU Lille, U995, LIRIC, Lille Inflammation Research International Center, F-59000 Lille, France.
authors: Philippe
authors: P
authors: Chavatte
mesh_terms: D000581:Amidohydrolases / Q000037:antagonists & inhibitors* / Q000627:therapeutic use*; D000818:Animals; D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D006801:Humans; D008994:Monoacylglycerol Lipases / Q000627:therapeutic use*; D000099252:Fatty Acid Amide Hydrolases
chemical_list: D000581:Amidohydrolases; D004791:Enzyme Inhibitors; D008994:Monoacylglycerol Lipases; D000099252:Fatty Acid Amide Hydrolases; C523108:NAAA protein, human