title: Extracellular Matrix and Colorectal Cancer: How Surrounding Microenvironment Affects Cancer Cell Behavior?
abstract: Colorectal cancer (CRC) whit more than a million of new cases per year is one of the most common registered cancers worldwide with few treatment options especially for advanced and metastatic patients.The tumor microenvironment is composed by extracellular matrix (ECM), cells, and interstitial fluids. Among all these constituents, in the last years an increased interest around the ECM and its potential role in cancer tumorigenesis is arisen. During cancer progression the ECM structure and composition became disorganized, allowing cellular transformation and metastasis. Up to now, the focus has mainly been on the characterization of CRC microenvironment analyzing separately structural ECM components or cell secretome modifications. A more extensive view that interconnects these aspects should be addressed. In this review, biochemical (secretome) and biomechanical (structure and architecture) changes of tumor microenvironment will be discussed, giving suggestions on how these changes can affect cancer cell behavior. J. Cell. Physiol. 232: 967-975, 2017. © 2016 Wiley Periodicals, Inc.
authors: Institute of Paediatric Research-Città della Speranza, Corso Stati Uniti 4, Padova, Italy.
authors: Sara
authors: S
authors: Crotti
authors: Institute of Paediatric Research-Città della Speranza, Corso Stati Uniti 4, Padova, Italy.
authors: Martina
authors: M
authors: Piccoli
authors: Department of Translational Research, IRCCS-National Cancer Institute, Aviano, Italy.
authors: Flavio
authors: F
authors: Rizzolio
authors: Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania.|Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy.
authors: Antonio
authors: A
authors: Giordano
authors: First Surgical Clinic Section, Department of Surgical, Oncological and Gastroenterological Sciences, University of Padua, Via Nicolo Giustiniani 2, Padova, Italy.
authors: Donato
authors: D
authors: Nitti
authors: Institute of Paediatric Research-Città della Speranza, Corso Stati Uniti 4, Padova, Italy.|First Surgical Clinic Section, Department of Surgical, Oncological and Gastroenterological Sciences, University of Padua, Via Nicolo Giustiniani 2, Padova, Italy.
authors: Marco
authors: M
authors: Agostini
mesh_terms: D003106:Colon / Q000473:pathology; D015179:Colorectal Neoplasms / Q000473:pathology*; D005109:Extracellular Matrix / Q000378:metabolism*; D006801:Humans; D059016:Tumor Microenvironment