title: Malignancies in Children with Human Immunodeficiency Virus Infection - Our Experience at Chandigarh, North India.
abstract: With improved survival in children living with human immunodeficiency virus (HIV) infection (CLHIV), malignancies are being increasingly recognized.
  
  
  
  Among the CLHIV registered at our institute from January 1994 to March 2015, children with malignancy were analysed in detail.
  
  
  
  In total, 734 children affected by HIV were registered. Out of these, 11 children (9 boys, 2 girls) were diagnosed to have malignancy. Malignancy was the presenting feature of HIV infection in 4 children. High-grade non-Hodgkin lymphoma (NHL) was the most common malignancy noted in 9 of 11 (81%) children, whereas the remaining 2 children had Hodgkin's lymphoma. Survival in our cohort was 80% among children in whom chemotherapy was initiated, and overall survival was 36% (4 of 11 children).
  
  
  
  NHL was the most common malignancy in CLHIV in our cohort. Low-conditioning chemotherapy protocols along with initiation of anti-retroviral therapy resulted in improved outcomes in CLHIV with malignancy.
authors: Pediatric Allergy and Immunology Unit, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
authors: Deepti
authors: D
authors: Suri
authors: Pediatric Allergy and Immunology Unit, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
authors: Sagar
authors: S
authors: Bhattad
authors: Pediatric Allergy and Immunology Unit, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
authors: Anju
authors: A
authors: Gupta
authors: Pediatric Hemato-Oncology Unit, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
authors: Amita
authors: A
authors: Trehan
authors: Pediatric Hemato-Oncology Unit, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
authors: Deepak
authors: D
authors: Bansal
authors: Department of Cytology and Gynaecological Pathology, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
authors: Arvind
authors: A
authors: Rajwanshi
authors: Department of Histopathology, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
authors: Ashim
authors: A
authors: Das
authors: Pediatric Allergy and Immunology Unit, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
authors: Amit
authors: A
authors: Rawat
authors: Pediatric Allergy and Immunology Unit, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
authors: Surjit
authors: S
authors: Singh
mesh_terms: D000293:Adolescent; D017677:Age Distribution; D002648:Child; D015331:Cohort Studies; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology; D006801:Humans; D007194:India; D016483:Lymphoma, AIDS-Related / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin; D008297:Male; D008499:Medical Records; D009369:Neoplasms / Q000150:complications* / Q000401:mortality; D012307:Risk Factors; D017678:Sex Distribution; D015996:Survival Rate
keywords: HIV; cancer; children.; lymphoma; malignancy