title: Centriole positioning in epithelial cells and its intimate relationship with planar cell polarity.
abstract: Planar cell polarity (PCP)-signaling and associated tissue polarization are evolutionarily conserved. A well documented feature of PCP-signaling in vertebrates is its link to centriole/cilia positioning, although the relationship of PCP and ciliogenesis is still debated. A recent report in Drosophila established that Frizzled (Fz)-PCP core signaling has an instructive input to polarized centriole positioning in non-ciliated Drosophila wing epithelia as a PCP read-out. Here, we review the impact of this observation in the context of recent descriptions of the relationship(s) of core Fz-PCP signaling and cilia/centriole positioning in epithelial and non-epithelial cells. All existing data are consistent with a model where Fz-PCP signaling functions upstream of centriole/cilia positioning, independent of ciliogenesis. The combined data sets indicate that the Fz-Dsh PCP complex is instructive for centriole/ciliary positioning via an actin-based mechanism. Thereby, centriole/cilia/centrosome positioning can be considered an evolutionarily conserved readout and common downstream effect of PCP-signaling from flies to mammals.
authors: Departamento de Bioquímica, Biología Molecular y Genética, Facultad de Ciencias, Universidad de Extremadura, Badajoz, Spain.
authors: Jose Maria
authors: JM
authors: Carvajal-Gonzalez
authors: Departamento de Bioquímica, Biología Molecular y Genética, Facultad de Ciencias, Universidad de Extremadura, Badajoz, Spain.
authors: Sonia
authors: S
authors: Mulero-Navarro
authors: Department of Developmental and Regenerative Biology and Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
authors: Marek
authors: M
authors: Mlodzik
mesh_terms: D000818:Animals; D016764:Cell Polarity; D002502:Centrioles / Q000502:physiology*; D004847:Epithelial Cells / Q000378:metabolism / Q000502:physiology*; D051157:Frizzled Receptors / Q000502:physiology*; D015398:Signal Transduction
chemical_list: D051157:Frizzled Receptors
keywords: Frizzled-Vangl signaling; actin cytoskeleton; centriole/MTOC localization; cilia; epithelial polarity; microtubules; planar cell polarity