title: The association between insulin-like growth factor 1 (IGF-1), IGF-binding proteins (IGFBPs), and the carboxyterminal propeptide of type I procollagen (PICP) in pre- and postmenopausal women with rheumatoid arthritis.
abstract: OBJECTIVE
  To assess the association between plasma levels of the insulin-like growth factor (IGF) system including IGF-1, IGF-binding proteins (IGFBPs) including IGFBP-1, total (t-)IGFBP-3 and functional (f-)IGFBP-3, and the carboxyterminal propeptide of type I procollagen (PICP) in pre- and postmenopausal women with rheumatoid arthritis (RA).
  
  
  METHODS
  Plasma concentrations of IGF-1, IGFBP-1, t-IGFBP-3, f-IGFBP-3, and PICP were measured by immunoassay.
  
  
  RESULTS
  No significant difference was observed in plasma IGF-1 levels between pre- and postmenopausal subjects. Plasma levels of IGFBP-1 were elevated in RA. PICP and f-IGFBP-3 were greatly affected by menopausal status. Of the three IGFBPs tested, only f-IGFBP-3 plasma levels in RA women correlated negatively with age and disease duration. A positive correlation was demonstrated between PICP and erythrocyte sedimentation rate (ESR) in RA. Moreover, there was no correlation between PICP and IGF-1 and any of the IGFBPs in RA women.
  
  
  CONCLUSIONS
  Considerable disruption of the IGF system in RA was found to be related to disease activity and duration. Changes in the IGF-IGFBP axis and PICP levels were different in pre- and postmenopausal women with RA. Elevated plasma PICP concentrations may indicate an increased rate of bone formation in postmenopausal RA women. Additionally, the observed changes in the IGF/IGFBP system did not affect bone formation during RA.
authors: a Department of Clinical Chemistry and Laboratory Diagnostics , School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia in Katowice , Sosnowiec , Poland.
authors: A
authors: A
authors: Szeremeta
authors: a Department of Clinical Chemistry and Laboratory Diagnostics , School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia in Katowice , Sosnowiec , Poland.
authors: A
authors: A
authors: Jura-Półtorak
authors: a Department of Clinical Chemistry and Laboratory Diagnostics , School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia in Katowice , Sosnowiec , Poland.
authors: K
authors: K
authors: Komosińska-Vassev
authors: b Department of Rheumatology , Silesian Centre for Rheumatology, Rehabilitation, and Prevention of Disability of Gen. Jerzy Ziętek in Ustroń , Ustroń , Poland.
authors: A
authors: A
authors: Zoń-Giebel
authors: b Department of Rheumatology , Silesian Centre for Rheumatology, Rehabilitation, and Prevention of Disability of Gen. Jerzy Ziętek in Ustroń , Ustroń , Poland.
authors: D
authors: D
authors: Kapołka
authors: a Department of Clinical Chemistry and Laboratory Diagnostics , School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia in Katowice , Sosnowiec , Poland.
authors: K
authors: K
authors: Olczyk
mesh_terms: D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000276:immunology / Q000378:metabolism*; D016723:Bone Remodeling; D001862:Bone Resorption / Q000378:metabolism; D002097:C-Reactive Protein / Q000276:immunology; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007118:Immunoassay; D018970:Insulin-Like Growth Factor Binding Protein 1 / Q000378:metabolism*; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000378:metabolism*; D018969:Insulin-Like Growth Factor Binding Proteins / Q000378:metabolism; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008875:Middle Aged; D010012:Osteogenesis; D010446:Peptide Fragments / Q000378:metabolism*; D010456:Peptides, Cyclic / Q000276:immunology; D017698:Postmenopause / Q000378:metabolism*; D017697:Premenopause / Q000378:metabolism*; D011347:Procollagen / Q000378:metabolism*; D012217:Rheumatoid Factor / Q000276:immunology / Q000378:metabolism*
chemical_list: C583557:IGF1 protein, human; C032231:IGFBP1 protein, human; C515497:IGFBP3 protein, human; D018970:Insulin-Like Growth Factor Binding Protein 1; D018972:Insulin-Like Growth Factor Binding Protein 3; D018969:Insulin-Like Growth Factor Binding Proteins; D010446:Peptide Fragments; D010456:Peptides, Cyclic; D011347:Procollagen; C487763:cyclic citrullinated peptide; C042813:procollagen type I carboxy terminal peptide; D007334:Insulin-Like Growth Factor I; D002097:C-Reactive Protein; D012217:Rheumatoid Factor