title: [Conversion of sound into auditory nerve action potentials].
abstract: Outer hair cells play a major role in the hearing process: they amplify the motion of the basilar membrane up to a 1000-fold and at the same time sharpen the excitation patterns. These patterns are converted by inner hair cells into action potentials of the auditory nerve. Outer hair cells are delicate structures and easily damaged, e. g., by overexposure to noise. Hearing aids can amplify the amplitude of the excitation patterns, but they cannot restore their degraded frequency selectivity. Noise overexposure also leads to delayed degeneration of auditory nerve fibers, particularly those with low a spontaneous rate, which are important for the coding of sound in noise. However, this loss cannot be diagnosed by pure-tone audiometry.
authors: Bioanaloge Informationsverarbeitung, Zentralinstitut für Medizintechnik, Technische Universität München, Boltzmannstr. 11, 85748, Garching, Deutschland.
authors: J
authors: J
authors: Encke
authors: Bioanaloge Informationsverarbeitung, Zentralinstitut für Medizintechnik, Technische Universität München, Boltzmannstr. 11, 85748, Garching, Deutschland.
authors: J
authors: J
authors: Kreh
authors: Bioanaloge Informationsverarbeitung, Zentralinstitut für Medizintechnik, Technische Universität München, Boltzmannstr. 11, 85748, Garching, Deutschland.
authors: F
authors: F
authors: Völk
authors: Bioanaloge Informationsverarbeitung, Zentralinstitut für Medizintechnik, Technische Universität München, Boltzmannstr. 11, 85748, Garching, Deutschland. werner.hemmert@tum.de.
authors: W
authors: W
authors: Hemmert
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods*; D000200:Action Potentials; D000818:Animals; D003056:Cochlear Nerve / Q000502:physiology*; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D018072:Hair Cells, Auditory, Outer / Q000502:physiology*; D006309:Hearing / Q000502:physiology*; D006801:Humans; D040542:Mechanotransduction, Cellular / Q000502:physiology*; D008959:Models, Neurological
keywords: Auditory perception; Cochlear hair cells; Computer models; Hearing loss; Inner ear