title: Two New Stilbenoids from the Aerial Parts of Arundina graminifolia (Orchidaceae).
abstract: Two new phenanthrene derivatives, a phenanthrenequinone named arundiquinone (1) and a 9,10-dihydrophenanthrene named arundigramin (2) together with a known lignin dimer (3) and seven known stilbenoids (4-10) were isolated from the aerial parts of the Asian orchidArundina graminifolia. The structures of the isolated compounds were elucidated by spectroscopic methods, including extensive 1D, 2D NMR (heteronuclear single quantum coherence (HSQC), heteronuclear multiple-bond correlation spectroscopy (HMBC), and HR-ESI-MS techniques, as well as comparison with respective literature reports. The cytoprotective activity of the isolated compounds were evaluated for their ability to reduce beta amyloid induced toxicity on undifferentiated PC12 cells. Compound8showed moderate cytoprotective activity at 0.5 µmol/L (71% of cell viability) while the other compounds showed no significant activity at the highest concentration tested.
authors: Laboratory of Pharmacognosy and Bioactive Natural Products, Faculty of Pharmacy, Strasbourg University, Illkirch-Graffenstaden 67400, France. florence.auberon@gmail.com.
authors: Florence
authors: F
authors: Auberon
authors: Laboratory of Pharmacognosy and Bioactive Natural Products, Faculty of Pharmacy, Strasbourg University, Illkirch-Graffenstaden 67400, France. pere@fastermail.com.
authors: Opeyemi Joshua
authors: OJ
authors: Olatunji
authors: GESVAB Group, Oenology Research Unit, EA 4577, USC 1366 INRA, ISVV, Faculty of Pharmacy, Bordeaux University, Villenave d'Ornon 33140, France. stephanie.krisa@u-bordeaux.fr.
authors: Stéphanie
authors: S
authors: Krisa
authors: Laboratoire Insulaire du Vivant et de l'Environnement, EA 4243, New-Caledonia University, BP R4, Noumea CEDEX 98851, New Caledonia. cyril.antheaume@univ-nc.nc.
authors: Cyril
authors: C
authors: Antheaume
authors: Spectropôle, FR1739, Aix-Marseille University, Campus de St Jerome-Service 511, Marseille 13397, France. gaetan.herbette@univ-amu.fr.
authors: Gaëtan
authors: G
authors: Herbette
authors: Louis Vuitton Moët et Hennessy Recherche, 185 avenue de Verdun, St Jean de Braye 45800, France. fredericbonte@research.lvmh-pc.com.
authors: Frédéric
authors: F
authors: Bonté
authors: GESVAB Group, Oenology Research Unit, EA 4577, USC 1366 INRA, ISVV, Faculty of Pharmacy, Bordeaux University, Villenave d'Ornon 33140, France. jean-michel.merillon@u-bordeaux.fr.
authors: Jean-Michel
authors: JM
authors: Mérillon
authors: Laboratory of Pharmacognosy and Bioactive Natural Products, Faculty of Pharmacy, Strasbourg University, Illkirch-Graffenstaden 67400, France. lobstein@unistra.fr.
authors: Annelise
authors: A
authors: Lobstein
mesh_terms: D016229:Amyloid beta-Peptides / Q000633:toxicity; D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D019610:Cytoprotection / Q000187:drug effects; D029595:Orchidaceae / Q000737:chemistry*; D016716:PC12 Cells; D035261:Plant Components, Aerial / Q000737:chemistry*; D051381:Rats; D013267:Stilbenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D016229:Amyloid beta-Peptides; D013267:Stilbenes
keywords: Arundina graminifolia; Orchidaceae; arundigramin; arundiquinone; phenanthrene derivatives