title: Second Primary Melanoma: Risk Factors, Histopathologic Features, Survival, and Implications for Follow-Up.
abstract: The impact on survival of a second primary melanoma (SPM) is unclear. We used our melanoma center's database to examine clinicopathologic risk factors and outcomes of stage 0 to IV cutaneous melanoma in patients with one versus two primaries. Among 12,325 patients with primary melanoma, 969 (7.86%) developed SPM. SPMs were significantly thinner than autologous primary melanomas (P = 0.01), and 451 SPM patients had better overall and melanoma-specific survival than 451 prognostically matched non-SPM patients (P < 0.0001 and 0.0001, respectively) at a median follow-up of 142.37 months. Patients with cutaneous melanoma are at high risk for development of SPM, but the development of SPM does not seem to impair survival.
authors: John Wayne Cancer Institute at Providence Saint John's Health Center, Santa Monica, California, USA.
authors: Maris S
authors: MS
authors: Jones
authors: Hitoe
authors: H
authors: Torisu-Itakura
authors: Devin C
authors: DC
authors: Flaherty
authors: Hans F
authors: HF
authors: Schoellhammer
authors: Jihey
authors: J
authors: Lee
authors: Myung-Shim
authors: MS
authors: Sim
authors: Mark B
authors: MB
authors: Faries
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D002140:California; D016208:Databases, Factual; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008545:Melanoma / Q000401:mortality* / Q000473:pathology* / Q000503:physiopathology; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000401:mortality* / Q000473:pathology* / Q000503:physiopathology; D012189:Retrospective Studies; D018570:Risk Assessment; D012737:Sex Factors; D012878:Skin Neoplasms / Q000401:mortality* / Q000473:pathology* / Q000503:physiopathology; D016019:Survival Analysis; D013997:Time Factors