title: Prognostic significance of miR-1268a expression and its beneficial effects for post-operative adjuvant transarterial chemoembolization in hepatocellular carcinoma.
abstract: Our recent investigation has shown that the variables of microRNA-1268a may involve in hepatocellular carcinoma (HCC) tumorigenesis. Here, we attempted to identify the prognostic significance of microRNA-1268a expression in tumor tissues by a retrospective analysis in 411 patients with HCC, and analyze its effects on post-operative adjuvant transarterial chemoembolization (TACE) improving HCC prognosis. All cases received tumor resection or tumor resection plus post-operative adjuvant TACE as an initial treatment. Logistical regression analysis exhibited that microRNA-1268a expression was significantly correlated with tumor stage, tumor grade, tumor size, and microvessel density. Cox regression analysis showed that microRNA-1268a expression was an independent prognostic factor for HCC, and TACE treatment had no effects on prognosis of HCC patients with high microRNA-1268a expression. More intriguingly, TACE improved the prognosis of HCC patients with low microRNA-1268a expression. Functionally, overexpression of microRNA-1268a inhibited while its inhibitor enhanced doxorubicin-induced the death of cancer cells. These results suggest that microRNA-1268a may be an independent prognostic factor for HCC patients, and that decreasing microRNA-1268a expression may be beneficial for post-operative adjuvant TACE treatment in HCC.
authors: Department of Pathology, the Affiliated Hospital of Youjiang Medical University for Nationalities, Baise 533000, P.R.China.
authors: Yun-Long
authors: YL
authors: Lu
authors: Department of Pathology, the Affiliated Hospital of Youjiang Medical University for Nationalities, Baise 533000, P.R.China.
authors: Jin-Guang
authors: JG
authors: Yao
authors: Department of Pathology, the Affiliated Hospital of Youjiang Medical University for Nationalities, Baise 533000, P.R.China.
authors: Xiao-Ying
authors: XY
authors: Huang
authors: Department of Medicine, the Affiliated Hospital of Youjiang Medical University for Nationalities, Baise 533000, P.R.China.
authors: Chao
authors: C
authors: Wang
authors: Department of Pathology, the Affiliated Hospital of Youjiang Medical University for Nationalities, Baise 533000, P.R.China.
authors: Xue-Min
authors: XM
authors: Wu
authors: Department of Liver Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, P.R.China.
authors: Qiang
authors: Q
authors: Xia
authors: Department of Pathology, the Affiliated Hospital of Youjiang Medical University for Nationalities, Baise 533000, P.R.China.|Department of Liver Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, P.R.China.
authors: Xi-Dai
authors: XD
authors: Long
mesh_terms: D000328:Adult; D006528:Carcinoma, Hepatocellular / Q000235:genetics / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D016461:Chemoembolization, Therapeutic; D018572:Disease-Free Survival; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008113:Liver Neoplasms / Q000235:genetics / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D008297:Male; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D055806:Microvessels / Q000502:physiology; D008875:Middle Aged; D016017:Odds Ratio; D011379:Prognosis; D012189:Retrospective Studies; D059467:Transcriptome
chemical_list: C000619243:MIRN1268 microRNA, human; D035683:MicroRNAs; D004317:Doxorubicin