title: Alicaforsen: An Emerging Therapeutic Agent for Ulcerative Colitis and Refractory Pouchitis.
abstract: Pouchitis is a relatively common complication that develops following ileal pouch-anal anastomosis in patients with complicated ulcerative colitis (UC). Both pouchitis and UC share similarities in their development, as well as in the mechanisms involving mediators of the inflammatory process. In the recent years, the discovery and investigation of biological therapies have led to advancement in the management of these disorders, and the continuation of research on this novel area holds strong implications for a future reduction in the use of invasive surgical procedures. Alicaforsen represents one of these emerging therapeutic agents, and has demonstrated promising results in both preclinical and clinical settings. This article reviews the therapeutic effects of alicaforsen for the management of UC and refractory pouchitis, with special emphasis on the mechanism of action of this therapeutic agent and the clinical studies asserting its effectiveness.
authors: Department of General Surgery, Tianjin Medical University General Hospital, Tianjin, China.
authors: Terron Anthony
authors: TA
authors: Hosten
authors: Department of General Surgery, Tianjin Medical University General Hospital, Tianjin, China.
authors: Ke
authors: K
authors: Zhao
authors: Department of General Surgery, Tianjin Medical University General Hospital, Tianjin, China.
authors: Hong Qiu
authors: HQ
authors: Han
authors: Department of General Surgery, Tianjin Medical University General Hospital, Tianjin, China.
authors: Gang
authors: G
authors: Liu
authors: Department of General Surgery, Tianjin Medical University General Hospital, Tianjin, China.
authors: Xiang Hui
authors: XH
authors: He
keywords: Alicaforsen; Refractory pouchitis; Ulcerative colitis