title: Stereotactic body radiotherapy for renal cell cancer and pancreatic cancer : Literature review and practice recommendations of the DEGRO Working Group on Stereotactic Radiotherapy.
abstract: OBJECTIVE
  This report of the Working Group on Stereotactic Radiotherapy of the German Society of Radiation Oncology (DEGRO) aims to provide a literature review and practice recommendations for stereotactic body radiotherapy (SBRT) of primary renal cell cancer and primary pancreatic cancer.
  
  
  METHODS
  A literature search on SBRT for both renal cancer and pancreatic cancer was performed with focus on prospective trials and technical aspects for clinical implementation.
  
  
  RESULTS
  Data on renal and pancreatic SBRT are limited, but show promising rates of local control for both treatment sites. For pancreatic cancer, fractionated SBRT should be preferred to single-dose treatment to reduce the risk of gastrointestinal toxicity. Motion-compensation strategies and image guidance are paramount for safe SBRT delivery in both tumor entities.
  
  
  CONCLUSIONS
  SBRT for renal cancer and pancreatic cancer have been successfully evaluated in phase I and phase II trials. Pancreatic SBRT should be practiced carefully and only within prospective protocols due to the risk of severe gastrointestinal toxicity. SBRT for primary renal cell cancer appears a viable option for medically inoperable patients but future research needs to better define patient selection criteria and the detailed practice of SBRT.
authors: Department of Radiation Oncology, Zurich University Hospital, Rämistrasse 100, 8091, Zurich, Switzerland.
authors: Cédric
authors: C
authors: Panje
authors: Department of Radiation Oncology, Zurich University Hospital, Rämistrasse 100, 8091, Zurich, Switzerland.
authors: Nikolaus
authors: N
authors: Andratschke
authors: Department of Radiation Oncology, Freiburg University Hospital, Freiburg, Germany.
authors: Thomas B
authors: TB
authors: Brunner
authors: Department of Radiation Oncology, University of Munich, Munich, Germany.
authors: Maximilian
authors: M
authors: Niyazi
authors: Department of Radiation Oncology, Zurich University Hospital, Rämistrasse 100, 8091, Zurich, Switzerland. matthias.guckenberger@usz.ch.
authors: Matthias
authors: M
authors: Guckenberger
mesh_terms: D002292:Carcinoma, Renal Cell / Q000532:radiotherapy*; D019317:Evidence-Based Medicine; D005767:Gastrointestinal Diseases / Q000209:etiology / Q000517:prevention & control*; D005858:Germany; D006801:Humans; D007680:Kidney Neoplasms / Q000532:radiotherapy*; D010190:Pancreatic Neoplasms / Q000532:radiotherapy*; D017410:Practice Guidelines as Topic; D011832:Radiation Injuries / Q000209:etiology / Q000517:prevention & control*; D018787:Radiation Oncology / Q000592:standards; D016634:Radiosurgery / Q000009:adverse effects / Q000592:standards*; D011879:Radiotherapy Dosage; D016896:Treatment Outcome
keywords: Pancreatic SBRT; Pancreatic cancer; Renal SBRT; Renal cell cancer; Stereotactic body radiotherapy