title: Serum C-Reactive Protein in Children with Liver Disease and Ascites.
abstract: BACKGROUND
  The diagnosis of peritonitis as a complication of cirrhosis is an important clinical problem.
  
  
  OBJECTIVE
  The aim of this study was to evaluate serum C-reactive protein levels as a diagnostic factor for spontaneous bacterial peritonitis (SBP) in child patients with liver disease.
  
  
  METHODS
  In this study, 150 children diagnosed with liver disease and ascites upon admission to Nemazee Teaching Hospital (Shiraz, Iran) were examined. Patients were divided into spontaneous bacterial peritonitis and sterile ascetic fluid groups according to the PMN count ≥ 250/mm3in the ascetic fluids. Routine laboratory tests were conducted and quantitative C-reactive protein (CRP) levels were measured for all of the patients. Accuracy, sensitivity, and specificity of CRP was evaluated for diagnosis of SBP.
  
  
  RESULTS
  Of 150 cirrhotic patients, 109 patients presented without SBP (52.29% male, mean age: 5.02 ± 4.49 years) and 41 patients presented with SBP (51.21% male, mean age: 4.71 years). Cell counts, protein levels, albumin levels, and lactate dehydrogenize (LDH) levels of the ascetic fluid and serum samples in the SBP group were higher than the rates for those without SBP (P < 0.05(. The mean ± SD of CRP in the SBP group (36.89 ± 23.43) increased significantly compared to the rate among those without SBP (21.59 ± 15.43, P = 0.001). The percentages for sensitivity and specificity of CRP, the diagnosis of SBP based on the PMN count ≥ 250/mm3, and cultured ascites were 69.23%, 90.25%, 88.43%, and 84.32%, respectively. The areas under the curve of CRP for SBP based on the PMN count ≥ 250/mm3and cultured ascites was 0.94 (CI 95%: 0.90 to 0.96) and 0.85 (CI 95%: 0.84 to 0.92), respectively (P < 0.001).
  
  
  CONCLUSIONS
  Our study showed that CRP is a marker with high sensitivity and specificity for the diagnosis of SBP in cirrhotic children.
authors: Department of Pediatrics, Ilam University of Medical Sciences, Ilam, IR Iran.
authors: Gholamreza
authors: G
authors: Kalvandi
authors: Department of Pediatric Gastroenterology, Nemazee Teaching Hospital, Shiraz University of Medical Sciences, Shiraz, IR Iran.
authors: Naser
authors: N
authors: Honar
authors: Department of Pathology, Nemazee Teaching Hospital, Shiraz University of Medical Sciences, Shiraz, IR Iran.
authors: Bita
authors: B
authors: Geramizadeh
authors: Department of Pediatric Gastroenterology, Nemazee Teaching Hospital, Shiraz University of Medical Sciences, Shiraz, IR Iran.
authors: Maryam
authors: M
authors: Ataollahi
authors: Student Research Committee, Ilam University of Medical Sciences, Ilam, IR Iran.
authors: Asghar
authors: A
authors: Rahmani
authors: Nursing Research Center in Chronic Diseases and Department of Pediatric Gastroenterology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran.
authors: Hazhir
authors: H
authors: Javaherizadeh
keywords: C-Reactive Protein; Cirrhosis; Peritonitis