title: Residential radon, EGFR mutations and ALK alterations in never-smoking lung cancer cases.
abstract: The aim of this study was to assess if residential radon exposure might cause EGFR mutations or ALK rearrangements in never-smokers.We designed a multicentre case-control study in a radon-prone area (Galicia, Spain); only lung cancer cases were included in the study. We obtained residential radon measurements and clinical information for all the participants. We compared the median values of residential radon between patients with EGFR mutations or ALK rearrangements versus those without them.323 patients were included. Median age was 70 years and 19.5% were males. 42 and 15% of patients were EGFR- and ALK-positive, respectively. The most frequent EGFR alterations were exon 19 deletions and exon 21 (L858R) single-point substitution mutations. ALK-positive patients were 10 years younger than ALK-negative patients. Residential radon levels were two-fold higher in patients with exon 19 deletions compared with patients with exon 21 (L858R) single-point substitution mutations (216 versus 118 Bq·m-3; p=0.057). There were no differences in residential radon levels by EGFR mutation status. ALK-positive patients (n=12) essentially had two-fold residential radon levels compared with ALK-negative patients (290 versus 164 Bq·m-3, respectively).Residential radon may have a role in the molecular signature of lung cancer in never-smokers, although more studies with larger sample sizes are needed to support this hypothesis.
authors: Dept of Preventive Medicine and Public Health, University of Santiago de Compostela, Santiago de Compostela, Spain alberto.ruano@usc.es.|CIBER de Epidemiología y Salud Pública, CIBERESP, Madrid, Spain.|Dept of Epidemiology, Brown School of Public Health, Brown University, Providence, RI, USA.
authors: Alberto
authors: A
authors: Ruano-Ravina
authors: Service of Pneumology, University Hospital Complex of Vigo, Vigo, Spain.
authors: María
authors: M
authors: Torres-Durán
authors: Dept of Epidemiology, Brown School of Public Health, Brown University, Providence, RI, USA.
authors: Karl T
authors: KT
authors: Kelsey
authors: Service of Pneumology, Ourense Hospital Complex, Ourense, Spain.
authors: Isaura
authors: I
authors: Parente-Lamelas
authors: Service of Pneumology, University Hospital Complex of Vigo, Vigo, Spain.
authors: Virginia
authors: V
authors: Leiro-Fernández
authors: Service of Pathology, Santiago de Compostela University Clinic Hospital, Santiago de Compostela, Spain.
authors: Ihab
authors: I
authors: Abdulkader
authors: Service of Pneumology, Ourense Hospital Complex, Ourense, Spain.
authors: José
authors: J
authors: Abal-Arca
authors: Service of Pneumology, University Hospital Complex of A Coruña, A Coruña, Spain.
authors: Carmen
authors: C
authors: Montero-Martínez
authors: Service of Pneumology, University Hospital Complex of A Coruña, A Coruña, Spain.
authors: Iria
authors: I
authors: Vidal-García
authors: Oncologic Hospital, A Coruña, Spain.
authors: Margarita
authors: M
authors: Amenedo
authors: Service of Pneumology, Hospital Lucus Augusti, Lugo, Spain.
authors: Olalla
authors: O
authors: Castro-Añón
authors: Service of Pneumology, Santiago de Compostela University Clinic Hospital, Santiago de Compostela, Spain.
authors: Antonio
authors: A
authors: Golpe-Gómez
authors: Service of Pneumology, Santiago de Compostela University Clinic Hospital, Santiago de Compostela, Spain.
authors: Javier
authors: J
authors: González-Barcala
authors: National Institute of Silicosis, University Hospital of Asturias, Oviedo, Spain.
authors: Cristina
authors: C
authors: Martínez
authors: National Institute of Silicosis, University Hospital of Asturias, Oviedo, Spain.
authors: Rosirys
authors: R
authors: Guzmán-Taveras
authors: Service of Oncology, Puerta de Hierro University Hospital, Madrid, Spain.
authors: Mariano
authors: M
authors: Provencio
authors: Service of Pneumology, Arquitecto Marcide Hospital, Ferrol, Spain.
authors: María José
authors: MJ
authors: Mejuto-Martí
authors: Service of Pneumology, University Hospital Complex of Vigo, Vigo, Spain.
authors: Alberto
authors: A
authors: Fernández-Villar
authors: Dept of Preventive Medicine and Public Health, University of Santiago de Compostela, Santiago de Compostela, Spain.|CIBER de Epidemiología y Salud Pública, CIBERESP, Madrid, Spain.|Service of Preventive Medicine, University Hospital Complex of Santiago de Compostela, Santiago de Compostela, Spain.
authors: Juan Miguel
authors: JM
authors: Barros-Dios
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000077548:Anaplastic Lymphoma Kinase; D016022:Case-Control Studies; D004781:Environmental Exposure; D066246:ErbB Receptors / Q000235:genetics*; D005091:Exons; D005260:Female; D017353:Gene Deletion; D015321:Gene Rearrangement; D006798:Housing; D006801:Humans; D008175:Lung Neoplasms / Q000209:etiology* / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009154:Mutation; D011886:Radon; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics*; D012907:Smoking; D013030:Spain
chemical_list: C000626173:ALK protein, human; D000077548:Anaplastic Lymphoma Kinase; C512478:EGFR protein, human; D066246:ErbB Receptors; D020794:Receptor Protein-Tyrosine Kinases; D011886:Radon