title: Sensitivity of C6 Glioma Cells Carrying the Human Poliovirus Receptor to Oncolytic Polioviruses.
abstract: A humanized line of rat C6 glioma cells expressing human poliovirus receptor was obtained and tested for the sensitivity to oncolytic effects of vaccine strains of type 1, 2, and 3 polioviruses. Presentation of the poliovirus receptor on the surface of C6 glioma cells was shown to be a necessary condition for the interaction of cells with polioviruses, but insufficient for complete poliovirus oncolysis.
authors: Department of Medical Nanobiotechnologies, Medical and Biological Faculty, N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russia. aososnovtceva@gmail.com.|Laboratory of Cell Proliferation, V. A. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia. aososnovtceva@gmail.com.
authors: A O
authors: AO
authors: Sosnovtseva
authors: Laboratory of Cell Proliferation, V. A. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.
authors: A V
authors: AV
authors: Lipatova
authors: Department of Basic and Applied Neurobiology, V. P. Serbsky Federal Medical Research Centre of Psychiatry and Narcology, Ministry of Health of the Russian Federation, Moscow, Russia.
authors: N F
authors: NF
authors: Grinenko
authors: Department of Medical Nanobiotechnologies, Medical and Biological Faculty, N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russia.
authors: V P
authors: VP
authors: Baklaushev
authors: Laboratory of Cell Proliferation, V. A. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.
authors: P M
authors: PM
authors: Chumakov
authors: Department of Medical Nanobiotechnologies, Medical and Biological Faculty, N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russia.|Department of Basic and Applied Neurobiology, V. P. Serbsky Federal Medical Research Centre of Psychiatry and Narcology, Ministry of Health of the Russian Federation, Moscow, Russia.
authors: V P
authors: VP
authors: Chekhonin
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D002470:Cell Survival; D015870:Gene Expression; D005822:Genetic Vectors / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D016086:Lentivirus / Q000235:genetics / Q000378:metabolism; D008164:Luminescent Proteins / Q000235:genetics / Q000378:metabolism; D009457:Neuroglia / Q000378:metabolism / Q000473:pathology / Q000821:virology*; D050130:Oncolytic Virotherapy / Q000379:methods; D050504:Oncolytic Viruses / Q000502:physiology*; D017955:Poliovirus / Q000502:physiology*; D011485:Protein Binding; D051381:Rats; D011991:Receptors, Virus / Q000235:genetics* / Q000378:metabolism; D011993:Recombinant Fusion Proteins / Q000235:genetics* / Q000378:metabolism; D014161:Transduction, Genetic; D019076:Transgenes; D019562:Viral Load / Q000502:physiology; D014779:Virus Replication / Q000502:physiology
chemical_list: D008164:Luminescent Proteins; D011991:Receptors, Virus; D011993:Recombinant Fusion Proteins; C409504:blue fluorescent protein, Aequorea victoria; C066100:poliovirus receptor
keywords: malignant gliomas; oncolytic viruses; poliovirus; poliovirus receptor; virotherapy