title: Association between Polyphenol Intake and Hypertension in Adults and Older Adults: A Population-Based Study in Brazil.
abstract: OBJECTIVE
  Hypertension is an important risk factor for cardiovascular disease, and diet has been identified as a modifiable factor for preventing and controlling hypertension. Besides, epidemiological studies have suggested an inverse association between polyphenol intake and cardiovascular diseases. The aim of this study was to evaluate the association between the intake of polyphenols and hypertension in a general population of Sao Paulo.
  
  
  METHODS
  Data came from the 'Health Survey of Sao Paulo (ISA-Capital)' among 550 adults and older adults in Sao Paulo, Brazil. Diet was assessed by two 24-hour dietary recalls (24HR). Usual intakes were calculated using the Multiple Source Method. Polyphenol intake was calculated by matching food consumption data from the 24HR with the Phenol-Explorer database. The associations between the hypertension and tertiles of the total and classes of polyphenols intake were tested by multivariate logistic regression analysis.
  
  
  RESULTS
  After multivariate adjustment for potential confounding factors the findings showed an inverse and linearly association between the hypertension and highest tertiles of tyrosols (OR = 0.33; 95%CI 0.18, 0.64), alkylphenols (OR = 0.45; 95%CI 0.23, 0.87), lignans (OR = 0.49; 95%CI 0.25, 0.98), as well as stilbenes (OR = 0.60; 95%CI 0.36, 0.98), and other polyphenols (OR = 0.33; 95%CI 0.14, 0.74). However, total polyphenol intake, and phenolic acids were significantly associated only in the middle tertile with hypertension and flavonoids were not significant associated.
  
  
  CONCLUSIONS
  There is an inverse and linearly association between the highest tertile of some classes of polyphenols, such as, tyrosols, alkylphenols, lignans, stilbenes, other polyphenols and hypertension.
authors: Department of Nutrition, School of Public Health, University of Sao Paulo, Sao Paulo, SP, Brazil.
authors: Andreia Machado
authors: AM
authors: Miranda
authors: Department of Nutrition, School of Public Health, University of Sao Paulo, Sao Paulo, SP, Brazil.
authors: Josiane
authors: J
authors: Steluti
authors: Department of Nutrition, School of Public Health, University of Sao Paulo, Sao Paulo, SP, Brazil.
authors: Regina Mara
authors: RM
authors: Fisberg
authors: Department of Nutrition, School of Public Health, University of Sao Paulo, Sao Paulo, SP, Brazil.
authors: Dirce Maria
authors: DM
authors: Marchioni
mesh_terms: D000328:Adult; D001938:Brazil / Q000453:epidemiology; D004034:Diet Surveys; D005260:Female; D005502:Food; D006306:Health Surveys; D006801:Humans; D006973:Hypertension / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D059808:Polyphenols / Q000737:chemistry / Q000494:pharmacology*; D055815:Young Adult
chemical_list: D059808:Polyphenols