title: Copper-Catalyzed anti-Markovnikov Hydroindolation of Terminal Alkynes: Regioselective Synthesis of Bis(indolyl)alkanes.
abstract: An efficient copper-catalyzed intermolecular hydroindolation reaction of terminal aryl alkynes to expeditiously synthesize bis(indolyl)alkanes in moderate to high yields is described. The double nucleophilic addition of two molecules of indole to one molecule of alkyne occurs in a tandem manner through an anti-Markovnikov pathway. Various arenes and alkynes allow for this transformation. Preliminary mechanistic study sheds light on the observed regioselectivity involving a Cu-vinylidene complex, and 3-styryl-1H-indole as probable intermediates.
authors: Department of Chemistry, Indian Institute of Technology , Delhi 110016, India.
authors: Ananya
authors: A
authors: Srivastava
authors: Department of Chemistry, Indian Institute of Technology , Delhi 110016, India.
authors: Shyam Sunder
authors: SS
authors: Patel
authors: Department of Chemistry, Indian Institute of Technology , Delhi 110016, India.
authors: Nisha
authors: N
authors: Chandna
authors: Department of Chemistry, Indian Institute of Technology , Delhi 110016, India.
authors: Nidhi
authors: N
authors: Jain