title: Phase I/IIa Study of Low Dose Subcutaneous Interleukin-2 (IL-2) for Treatment of Refractory Chronic Graft Versus Host Disease.
abstract: Chronic graft versus host disease (cGVHD) remains a major problem for long survivors after allogeneic hematopoietic stem cell transplantation (HSCT). Currently, corticosteroid therapy is effective for cGVHD as the first line therapy. However, prolonged therapy with corticosteroids causes various severe adverse events. To develop the new therapeutic strategy of cGVHD, we have launched a multicenter phase I/IIa clinical trial of low dose subcutaneous interleukin-2 (IL-2) for treatment of steroid refractory cGVHD, which is constituted of 2 sequential phases (induction phase and maitanance phase). This study will provide the new therapeutic option for patients with refractory cGVHD after allogeneic HSCT.
authors: Department of Hematology and Oncology, Okayama University Hospital, Okayama 700-8558, Japan.
authors: Takeru
authors: T
authors: Asano
authors: Department of Hematology and Oncology, Okayama University Hospital.
authors: Ken-Ichi
authors: KI
authors: Matsuoka
authors: Department of Medical Oncology and Hematology, Sapporo Medical University Hospital.
authors: Satoshi
authors: S
authors: Iyama
authors: Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital.
authors: Kazuteru
authors: K
authors: Ohashi
authors: Department of Hematopoietic Stem Cell Transplantation,National Cancer Center Hospital.
authors: Yoshihiro
authors: Y
authors: Inamoto
authors: Department of Hematology, Chiba University Hospital.
authors: Chikako
authors: C
authors: Ohwada
authors: Department of Hematology and Oncology, Nagoya University Graduate School of Medicine.
authors: Makoto
authors: M
authors: Murata
authors: First Department of Internal Medicine, Kansai Medical University.
authors: Atsushi
authors: A
authors: Satake
authors: Division of Hematology, National Hospital Organization Minami-Okayama Medical Center.
authors: Chikamasa
authors: C
authors: Yoshida
authors: Division of Hematology, Ehime Prefectural Central Hospital.
authors: Koichi
authors: K
authors: Nakase
authors: Department of Hematology and Oncology, Kyushu University Hospital.
authors: Yasuo
authors: Y
authors: Mori
authors: Department of Hematology and Oncology, Okayama University Hospital.
authors: Mitsune
authors: M
authors: Tanimoto
mesh_terms: D002985:Clinical Protocols; D006086:Graft vs Host Disease / Q000188:drug therapy*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007279:Injections, Subcutaneous; D007376:Interleukin-2 / Q000008:administration & dosage* / Q000627:therapeutic use
chemical_list: D007376:Interleukin-2