title: Amide of Lambertian Acid Suppresses Hyperactivation of Inotropic Glutamate Receptors, but not Synaptic Potentiation in Hippocampal Sections.
abstract: Amide of lambertian acid suppresses hyperactivation of inotropic glutamate receptors in hippocampal sections induced by a decrease in the level of magnesium ions (a selective blocker of glutamate NMDA receptors). Treatment of the sections with amide of lambertian acid in standard physiological saline does not prevent development of NMDA-dependent synaptic potentiation. Lambertian acid isolated from needles and turpentine of Siberian pine (Pinus sibirica R. Mayr), and its derivatives may become a source of substances with glutamatergic mechanism of action for treatment of cognitive and neurodegenerative disorders.
authors: Design Technological Institute of Digital Techniques, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia. svetavech@yandex.ru.
authors: S O
authors: SO
authors: Vechkapova
authors: Design Technological Institute of Digital Techniques, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
authors: T A
authors: TA
authors: Zapara
authors: N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
authors: E A
authors: EA
authors: Morozova
authors: Design Technological Institute of Digital Techniques, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
authors: A L
authors: AL
authors: Proskura
authors: N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
authors: E E
authors: EE
authors: Schul'ts
authors: N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
authors: T G
authors: TG
authors: Tolstikova
authors: Design Technological Institute of Digital Techniques, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
authors: A S
authors: AS
authors: Ratushnyak
mesh_terms: D000577:Amides / Q000737:chemistry; D000818:Animals; D056547:CA1 Region, Hippocampal / Q000166:cytology / Q000187:drug effects / Q000502:physiology; D002264:Carboxylic Acids / Q000302:isolation & purification / Q000494:pharmacology*; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D017774:Long-Term Potentiation / Q000502:physiology; D008274:Magnesium / Q000494:pharmacology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008867:Microtomy; D009281:Naphthalenes / Q000302:isolation & purification / Q000494:pharmacology*; D009474:Neurons / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D018696:Neuroprotective Agents / Q000302:isolation & purification / Q000494:pharmacology*; D028223:Pinus / Q000737:chemistry; D058468:Receptors, Ionotropic Glutamate / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013569:Synapses / Q000502:physiology; D046509:Tissue Culture Techniques
chemical_list: D000577:Amides; D002264:Carboxylic Acids; D018691:Excitatory Amino Acid Antagonists; D009281:Naphthalenes; D018696:Neuroprotective Agents; D058468:Receptors, Ionotropic Glutamate; C421442:lambertianic acid; D008274:Magnesium
keywords: amide of lambertian acid; hippocampal sections; hyperactivation of glutamatergic receptors; post-tetanic synaptic potentiation