title: Targeting cardiac natriuretic peptides in the therapy of diabetes and obesity.
abstract: Atrial and B-type Natriuretic Peptides (NP) are cardiac hormones with potent cardiovascular and metabolic effects. They signal through the NPRA/cGMP system and are inactivated by a clearance receptor NPRC and neutral endopeptidases (NEP). Recombinant ANP and BNP are currently used as drug treatment for acute decompensated congestive heart failure. Recent literature indicate that a defective NP system is linked to obesity and predict the risk of type 2 diabetes (T2D). Areas covered: This article reviews recent epidemiological, clinical and preclinical evidences that NP system deficiency may be causal of obesity and T2D. The molecular mechanisms of the NP pathway in several metabolic target tissues are presented. The therapeutic potential of NP in obesity and T2D is discussed. Expert opinion: Targeting the NP pathway may offer a novel therapeutic avenue for the management of obesity and T2D. The benefit/risk of drugs increasing circulating NP levels by blocking NPRC and NEP, and/or enhancing NPRA signaling should be assessed in obese and type 2 diabetic individuals.
authors: a INSERM, UMR1048, Institute of Metabolic and Cardiovascular Diseases , Toulouse , France.|b University of Toulouse, Paul Sabatier University , Toulouse , France.
authors: Cedric
authors: C
authors: Moro
mesh_terms: D000818:Animals; D009320:Atrial Natriuretic Factor / Q000172:deficiency / Q000187:drug effects / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D058990:Molecular Targeted Therapy; D020097:Natriuretic Peptide, Brain / Q000172:deficiency / Q000187:drug effects / Q000378:metabolism*; D015260:Neprilysin / Q000378:metabolism; D009765:Obesity / Q000188:drug therapy* / Q000473:pathology; D017461:Receptors, Atrial Natriuretic Factor / Q000378:metabolism
chemical_list: D020097:Natriuretic Peptide, Brain; D009320:Atrial Natriuretic Factor; D015260:Neprilysin; D017461:Receptors, Atrial Natriuretic Factor; C073616:atrial natriuretic factor receptor C
keywords: Adipose tissue; cGMP; fat oxidation; insulin resistance; lipolysis; skeletal muscle