title: Lignans from the shed trunk barks of the critically endangered plant Abies beshanzuensis and their anti-neuroinflammatory activities.
abstract: During a further and comprehensive phytochemical investigation on the shed trunk barks of the critically endangered plant Abies beshanzuensis, one new (1) and ten known (2-11) lignans with diverse structures were isolated. On the basis of spectroscopic methods, the new structure was established to be (7S,8R,8'R)-4'-methoxyl-α-conidendrin (1). Among the isolated lignans, (-)-matairesinol (5) and (-)-arctigenin (6) showed significant anti-neuroinflammatory activities by inhibiting the overproduction of nitric oxide in lipopolysaccharide-stimulated murine BV-2 microglial cells, with IC50values of 11.5 and 19.0 μM, respectively.
authors: a Department of Natural Products Chemistry, School of Pharmacy , Fudan University , Shanghai , P.R. China.
authors: Chang-Ling
authors: CL
authors: Hu
authors: a Department of Natural Products Chemistry, School of Pharmacy , Fudan University , Shanghai , P.R. China.
authors: Juan
authors: J
authors: Xiong
authors: b Department of Pharmacology, School of Pharmacy , Fudan University , Shanghai , P.R. China.
authors: Peng
authors: P
authors: Xu
authors: c Chemical Biology Center , Lishui Institute of Agricultural Sciences , Lishui , P.R. China.
authors: Ke-Jun
authors: KJ
authors: Cheng
authors: a Department of Natural Products Chemistry, School of Pharmacy , Fudan University , Shanghai , P.R. China.
authors: Guo-Xun
authors: GX
authors: Yang
authors: a Department of Natural Products Chemistry, School of Pharmacy , Fudan University , Shanghai , P.R. China.
authors: Jin-Feng
authors: JF
authors: Hu
mesh_terms: D028202:Abies / Q000737:chemistry*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000302:isolation & purification* / Q000494:pharmacology; D002478:Cells, Cultured; D005663:Furans / Q000494:pharmacology; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D051379:Mice; D017628:Microglia / Q000187:drug effects; D009569:Nitric Oxide / Q000096:biosynthesis; D024301:Plant Bark / Q000737:chemistry
chemical_list: D000893:Anti-Inflammatory Agents; D005663:Furans; D017705:Lignans; D009569:Nitric Oxide; C068935:matairesinol; C071942:arctigenin
keywords: Abies beshanzuensis; Pinaceae; anti-neuroinflammation; endangered plant; lignans