title: Current status on clinical applications of magnesium-based orthopaedic implants: A review from clinical translational perspective.
abstract: As a new generation of medical metallic material, magnesium (Mg) and its alloys with or without surface coating have attracted a great deal of attention due to its biodegradability and potential for avoiding a removal operation after the implant has fulfilled its function for surgical fixation of injured musculoskeletal tissues. Although a few clinical cases on Mg-based orthopaedic implants were reported more than a century ago, it was not until recently that clinical trials using these implants with improved physicochemical properties were carried out in Germany, China and Korea for bone fracture fixation. The promising results so far suggest a bright future for biodegradable Mg-based orthopaedic implants and would warrant large scale phase II/III studies. Given the increasing interest on this emerging biomaterials and intense effort to improve its properties for various clinical applications, this review covers the evolution, current strategies, and future perspectives in the development of Mg-based orthopaedic implants. We also highlight a few clinical cases performed in China that may be unfamiliar to the general orthopaedic community.
authors: Department of Orthopaedics, Affiliated Zhongshan Hospital of Dalian University, Dalian, China. Electronic address: zhaodewei2000@163.com.
authors: Dewei
authors: D
authors: Zhao
authors: Julius Wolff Institute and Center for Musculoskeletal Surgery, Berlin-Brandenburg Center for Regenerative Therapies, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany.
authors: Frank
authors: F
authors: Witte
authors: Department of Orthopaedics, Affiliated Zhongshan Hospital of Dalian University, Dalian, China.
authors: Faqiang
authors: F
authors: Lu
authors: Musculoskeletal Research Laboratory, Department of Orthopaedics & Traumatology, The Chinese University of Hong Kong, Hong Kong Special Administrative Region.
authors: Jiali
authors: J
authors: Wang
authors: Department of Orthopaedics, Affiliated Zhongshan Hospital of Dalian University, Dalian, China.
authors: Junlei
authors: J
authors: Li
authors: Musculoskeletal Research Laboratory, Department of Orthopaedics & Traumatology, The Chinese University of Hong Kong, Hong Kong Special Administrative Region; Center for Translational Medicine Research and Development, Institute of Biomedical Engineering, Chinese Academy of Sciences, Shenzhen 518055, China. Electronic address: lingqin@cuhk.edu.hk.
authors: Ling
authors: L
authors: Qin
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D019544:Equipment Failure Analysis; D006801:Humans; D016268:Internal Fixators / Q000639:trends*; D007595:Joint Prosthesis / Q000639:trends*; D008274:Magnesium / Q000737:chemistry*; D011474:Prosthesis Design / Q000639:trends
chemical_list: D001672:Biocompatible Materials; D008274:Magnesium
keywords: Contents; Magnesium; Orthopaedic application; Translational medicine