title: Type 3 adenylyl cyclase: a key enzyme mediating the cAMP signaling in neuronal cilia.
abstract: Cilia are rigid, centriole-derived, microtubule-based organelles present in a majority of vertebrate cells including neurons. They are considered the cellular "antennae" attuned for detecting a range of extracellular signals including photons, odorants, morphogens, hormones and mechanical forces. The ciliary microenvironment is distinct from most actin-based subcellular structures such as microvilli or synapses. In the nervous system, there is no evidence that neuronal cilia process any synaptic structure. Apparently, the structural features of neuronal cilia do not allow them to harbor any synaptic connections. Nevertheless, a large number of G protein-coupled receptors (GPCRs) including odorant receptors, rhodopsin, Smoothened, and type 6 serotonin receptor are found in cilia, suggesting that these tiny processes largely depend on metabotropic receptors and their tuned signals to impact neuronal functions. The type 3 adenylyl cyclase (AC3), widely known as a cilia marker, is highly and predominantly expressed in olfactory sensory cilia and primary cilia throughout the brain. We discovered that ablation of AC3 in mice leads to pleiotropic phenotypes including anosmia, failure to detect mechanical stimulation of airflow, cognitive deficit, obesity, and depression-like behaviors. Multiple lines of human genetic evidence also demonstrate that AC3 is associated with obesity, major depressive disorder (MDD), sarcoidosis, and infertility, underscoring its functional importance. Here we review recent progress on AC3, a key enzyme mediating the cAMP signaling in neuronal cilia.
authors: Department of Molecular, Cellular, and Biomedical Sciences, College of Life Science and Agriculture, University of New Hampshire Durham, NH 03824, USA.
authors: Liyan
authors: L
authors: Qiu
authors: Department of Molecular, Cellular, and Biomedical Sciences, College of Life Science and Agriculture, University of New Hampshire Durham, NH 03824, USA.
authors: Robert P
authors: RP
authors: LeBel
authors: Department of Pharmacology, School of Medicine, University of Washington Seattle, WA, 98195-7750, USA.
authors: Daniel R
authors: DR
authors: Storm
authors: Department of Molecular, Cellular, and Biomedical Sciences, College of Life Science and Agriculture, University of New Hampshire Durham, NH 03824, USA.
authors: Xuanmao
authors: X
authors: Chen
keywords: AC3; cAMP signaling; depression; mechanosensation; obesity; olfaction; primary cilia