title: Hepatitis C Virus Associations with Non Hodgkin's Lymphoma: Insights on Inflammation/Angiogenesis and CD Markers.
abstract: We aimed to investigate any association between hepatitis C virus (HCV) infection and non-Hodgkin’s
  lymphoma (NHL) in the view of cytokines that control inflammation/angiogenesis and their correlation with
  certain CD markers. NHL patients with or without HCV infection were studied. CD5, CD30, CD3, CD20 and
  CD45 were immunohistochemically evaluated. Plasma levels of vascular endothelial and platelet derived growth
  factors (VEGF, and PDGF), tumor necrosis factor (TNF-α), transforming growth factor (TGF-β), interleukin-6
  (IL-6), IL-8, IL-4, IL-12 and interferon gamma (IFN-γ) were detected by enzyme-linked immunosorbent assay
  (ELISA). HCV+ve NHL patients showed a significant reduction in VEGF, PDGF, IFN-γ, CD5 and CD45 and a
  significant increase in IL-12 and IL-8. In conclusion, there was a significant change in cytokine secretion and
  expression of CD markers in HCV+ve NHL patients. Based on our results, HCV infection in NHL patients
  requires more in-depth investigations to explore any role in lymphoma progression.
authors: Molecular Biology Department, Genetic Engineering and Biotechnology Research Institute (GEBRI), University of Sadat City, Egypt E-mail : roba.talaat@gebri.usc.edu.eg, robamtalaat@yahoo.com.
authors: Eman A
authors: EA
authors: El-Maadawy
authors: Roba M
authors: RM
authors: Talaat
authors: Rawia F
authors: RF
authors: Sadek
authors: Sherif M
authors: SM
authors: El-Sherbini
authors: Naser
authors: N
authors: Abdel-Bary
authors: Amal A
authors: AA
authors: Abdel-Aziz
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000378:metabolism*; D014408:Biomarkers, Tumor; D005260:Female; D016174:Hepacivirus / Q000472:pathogenicity; D006526:Hepatitis C / Q000150:complications*; D006801:Humans; D007249:Inflammation / Q000378:metabolism / Q000473:pathology* / Q000821:virology; D007371:Interferon-gamma / Q000378:metabolism; D018664:Interleukin-12 / Q000378:metabolism; D015847:Interleukin-4 / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism; D016209:Interleukin-8 / Q000378:metabolism; D008228:Lymphoma, Non-Hodgkin / Q000209:etiology* / Q000378:metabolism / Q000473:pathology* / Q000821:virology; D008297:Male; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000378:metabolism / Q000473:pathology* / Q000821:virology; D010982:Platelet-Derived Growth Factor / Q000378:metabolism; D016212:Transforming Growth Factor beta / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism; D055815:Young Adult
chemical_list: D015703:Antigens, CD; D014408:Biomarkers, Tumor; D015850:Interleukin-6; D016209:Interleukin-8; D010982:Platelet-Derived Growth Factor; D016212:Transforming Growth Factor beta; D014409:Tumor Necrosis Factor-alpha; D042461:Vascular Endothelial Growth Factor A; D018664:Interleukin-12; D015847:Interleukin-4; D007371:Interferon-gamma