title: Single-lung ventilation and oxidative stress: a different perspective on a common practice.
abstract: OBJECTIVE
  To summarize what is currently known about the relationship between single-lung ventilation (SLV), oxidative stress, and postoperative disruption of organ function.
  
  
  RESULTS
  SLV produces progressive alelectasis that is associated with hypoxic pulmonary vasoconstriction and redistribution of blood flow away from the nonventilated lung. This local tissue hypoxia induces the generation of reactive oxygen and reactive nitrogen species, an effect subsequently amplified by lung re-expansion consistent with well described hypoxia/reperfusion responses. Both experimental and clinical data indicate that the magnitude of oxidative and nitrosative stress is related to the duration of SLV and that these stresses affect not only the collapsed/re-expanded lung, but other organs as well.
  
  
  CONCLUSIONS
  SLV and subsequent re-expansion of atelectatic lung are associated with the generation of reactive oxygen and nitrogen species that may modulate persistent systemic effects.
authors: aDepartment of Anesthesiology, Yale Medical School, New Haven, Connecticut bDepartment of Anesthesiology, Physiology, and Biomedical Engineering, Medical College of Wisconsin cMarquette University, Milwaukee, Wisconsin, USA.
authors: Paul M
authors: PM
authors: Heerdt
authors: David F
authors: DF
authors: Stowe
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use; D006801:Humans; D008168:Lung / Q000098:blood supply / Q000378:metabolism / Q000503:physiopathology*; D023421:Models, Animal; D061810:One-Lung Ventilation / Q000009:adverse effects* / Q000379:methods; D018384:Oxidative Stress; D011183:Postoperative Complications / Q000209:etiology* / Q000517:prevention & control; D001261:Pulmonary Atelectasis / Q000209:etiology / Q000503:physiopathology; D017382:Reactive Oxygen Species / Q000378:metabolism; D012039:Regional Blood Flow; D015427:Reperfusion Injury / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control; D019616:Thoracic Surgical Procedures / Q000009:adverse effects*; D013997:Time Factors
chemical_list: D000975:Antioxidants; D017382:Reactive Oxygen Species