title: Neuromodulation of the Feedforward Dentate Gyrus-CA3 Microcircuit.
abstract: The feedforward dentate gyrus-CA3 microcircuit in the hippocampus is thought to activate ensembles of CA3 pyramidal cells and interneurons to encode and retrieve episodic memories. The creation of these CA3 ensembles depends on neuromodulatory input and synaptic plasticity within this microcircuit. Here we review the mechanisms by which the neuromodulators aceylcholine, noradrenaline, dopamine, and serotonin reconfigure this microcircuit and thereby infer the net effect of these modulators on the processes of episodic memory encoding and retrieval.
authors: Centre for Synaptic Plasticity, School of Physiology, Pharmacology and Neuroscience, University of Bristol Bristol, UK.
authors: Luke Y
authors: LY
authors: Prince
authors: Centre for Synaptic Plasticity, School of Physiology, Pharmacology and Neuroscience, University of Bristol Bristol, UK.
authors: Travis J
authors: TJ
authors: Bacon
authors: Centre for Synaptic Plasticity, School of Physiology, Pharmacology and Neuroscience, University of Bristol Bristol, UK.
authors: Cezar M
authors: CM
authors: Tigaret
authors: Centre for Synaptic Plasticity, School of Physiology, Pharmacology and Neuroscience, University of Bristol Bristol, UK.
authors: Jack R
authors: JR
authors: Mellor
keywords: CA3; acetylcholine; computational modeling; dentate gyrus; dopamine; mossy fiber; noradrenaline; serotonin