title: [Clinical significance of serum carbohydrate antigen 125 in acute exacerbation of chronic obstructive pulmonary disease].
abstract: OBJECTIVE
  To study the serum level of carbohydrate antigen 125 (CA125) in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and its relation with pulmonary hypertension.
  
  
  METHODS
  Forty-six patients with AECOPD complicated by pulmonary hypertension, 46 with AECOPD and 38 healthy control subjects were examined for their clinical data, pulmonary function, echocardiographic findings, and serum levels of lung tumor markers and brain natriuretic peptide (BNP).
  
  
  RESULTS
  Compared with the healthy control group, COPD patients with or without pulmonary hypertension showed significantly decreased pulmonary function (P<0.05), especially in those with AECOPD and concurrent pulmonary hypertension (P<0.05). Serum CA125 level was obviously higher in AECOPD group than in the healthy control group, and further increased in AECOPD patients with pulmonary hypertension (P<0.05). The levels of lung tumor markers (CEA, NSE, CYFRA and PROGRP) were similar among the 3 groups (P>0.05). The serum level of BNP in patients with AECOPD and concurrent pulmonary hypertension was significantly higher than that in patients with AECOPD (P<0.05). Pearson linear correlation analysis showed that serum CA125 was positively correlated with pulmonary artery systolic pressure and BNP in AECOPD patients with pulmonary hypertension (P<0.01).
  
  
  CONCLUSIONS
  Serum CA125 may serve as a serological index to identify AECOPD patients with pulmonary hypertension.
authors: Department of Respiratory Medicine, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China. E-mail: zhangmingdr@163.com.
authors: Ming
authors: M
authors: Zhang
authors: Ya-Li
authors: YL
authors: Li
authors: Xia
authors: X
authors: Yang
authors: Hu
authors: H
authors: Shan
authors: Qiu-Hong
authors: QH
authors: Zhang
authors: Xiang-Li
authors: XL
authors: Feng
authors: Ying-Ying
authors: YY
authors: Xie
authors: Jing-Jing
authors: JJ
authors: Tang
authors: Jie
authors: J
authors: Zhang
mesh_terms: D000208:Acute Disease; D014408:Biomarkers, Tumor; D018394:CA-125 Antigen / Q000097:blood*; D016022:Case-Control Studies; D018450:Disease Progression; D006801:Humans; D006976:Hypertension, Pulmonary / Q000503:physiopathology; D008168:Lung; D020097:Natriuretic Peptide, Brain / Q000097:blood; D029424:Pulmonary Disease, Chronic Obstructive / Q000097:blood* / Q000503:physiopathology
chemical_list: D014408:Biomarkers, Tumor; D018394:CA-125 Antigen; D020097:Natriuretic Peptide, Brain