title: NanoSIMS imaging: an approach for visualizing and quantifying lipids in cells and tissues.
abstract: Over the past few decades, several approaches have been used to image lipids in cells and tissues, but most have limited spatial resolution and sensitivity. Here, we discuss a relatively new approach, nanoscale secondary ion mass spectrometry imaging, that makes it possible to visualize lipids in cells and tissues in a quantitative fashion and with high spatial resolution and high sensitivity.
authors: Departments of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California, USA.
authors: Cuiwen
authors: C
authors: He
authors: Departments of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California, USA.
authors: Loren G
authors: LG
authors: Fong
authors: Departments of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California, USA.|Departments of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, California, USA.
authors: Stephen G
authors: SG
authors: Young
authors: Centre for Microscopy, Characterisation, and Analysis, The University of Western Australia, Perth, Western Australia, Australia.
authors: Haibo
authors: H
authors: Jiang
mesh_terms: D000818:Animals; D002477:Cells / Q000378:metabolism*; D006801:Humans; D008055:Lipids / Q000032:analysis*; D036103:Nanotechnology / Q000379:methods*; D009928:Organ Specificity; D018629:Spectrometry, Mass, Secondary Ion / Q000379:methods*
chemical_list: D008055:Lipids
keywords: Lipids