title: CX43 Expression in Colonic Adenomas and Surrounding Mucosa Is a Marker of Malignant Potential.
abstract: Colorectal cancer is a major public health problem. The adenoma-carcinoma sequence offers potential for screening and surveillance. We tested the clinical behavior and diagnostic utility of connexin 43 (CX43) in connection with pathohistological risk.
  
  
  
  Immunohistochemical expression of CX43 in colonic adenomas and surrounding mucosa from 87 patients was determined.
  
  
  
  CX43 expression was higher in mucosa surrounding adenomas with high-grade dysplasia (p=0.047), larger adenomas (p=0.015) and villous adenomas (p=0.02). No difference of CX43 expression in adenomas according to grade of dysplasia was found (p=0.87). CX43 expression in adenomas was dependent on the patient's hemoglobin level (p=0.002), family history of colorectal cancer (p=0.009) and statin therapy (p=0.049).
  
  
  
  CX43 expression in mucosa surrounding adenoma could be an additional factor indicative of malignant potential. CX43 expression in colonic adenoma seems to be closely related to family history of colorectal cancer, statin therapy and hemoglobin level.
authors: Division of Gastroenterology, Department of Internal Medicine, University Hospital Centre Sestre Milosrdnice, University of Zagreb School of Medicine and University of Zagreb School of Dental Medicine, Zagreb, Croatia alen.biscanin@gmail.com.
authors: Alen
authors: A
authors: Bišćanin
authors: Division of Gastroenterology, Department of Internal Medicine, University Hospital Centre Sestre Milosrdnice, University of Zagreb School of Medicine and University of Zagreb School of Dental Medicine, Zagreb, Croatia.
authors: Neven
authors: N
authors: Ljubičić
authors: Department of Cardiology, University Hospital Thalassotherapia Opatija, Medical Faculty University of Rijeka, Opatija, Croatia.|Department of Internal Medicine, University Hospital Osijek, Medical Faculty JJ Strossmayer University of Osijek, Osijek, Croatia.
authors: Marko
authors: M
authors: Boban
authors: Ljudevit Jurak University Department of Pathology, University Hospital Centre Sestre Milosrdnice, University of Zagreb School of Medicine and University of Zagreb School of Dental Medicine, Zagreb, Croatia.
authors: Drinko
authors: D
authors: Baličević
authors: Ljudevit Jurak University Department of Pathology, University Hospital Centre Sestre Milosrdnice, University of Zagreb School of Medicine and University of Zagreb School of Dental Medicine, Zagreb, Croatia.
authors: Ivana
authors: I
authors: Pavić
authors: Department of Prosthodontics, Zagreb Dental Clinic, Zagreb, Croatia.
authors: Mirela Maver
authors: MM
authors: Bišćanin
authors: Division of Gastroenterology, Department of Internal Medicine, University Hospital Centre Sestre Milosrdnice, University of Zagreb School of Medicine and University of Zagreb School of Dental Medicine, Zagreb, Croatia.
authors: Ivan
authors: I
authors: Budimir
authors: Division of Gastroenterology, Department of Internal Medicine, University Hospital Centre Sestre Milosrdnice, University of Zagreb School of Medicine and University of Zagreb School of Dental Medicine, Zagreb, Croatia.
authors: Zdravko
authors: Z
authors: Dorosulic
authors: Division of Gastroenterology, Department of Internal Medicine, University Hospital Centre Sestre Milosrdnice, University of Zagreb School of Medicine and University of Zagreb School of Dental Medicine, Zagreb, Croatia.
authors: Marko
authors: M
authors: Duvnjak
mesh_terms: D000236:Adenoma / Q000378:metabolism* / Q000473:pathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism*; D003110:Colonic Neoplasms / Q000378:metabolism* / Q000473:pathology; D018031:Connexin 43 / Q000378:metabolism*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
chemical_list: D014408:Biomarkers, Tumor; D018031:Connexin 43
keywords: CX43; colorectal cancer; malignant potential of adenoma