title: Tobacco use is associated with increased plasma BDNF levels in depressed patients.
abstract: Since serum Brain Derived Neurotrophic Factor (BDNF) levels are higher in tobacco smokers than in non-smokers and since Major Depressive Disorder (MDD) is associated with a 2-fold increased risk of smoking, we assessed the association of smoking and plasma BDNF levels in 359 depressed MDD patients. Plasma BDNF levels were positively correlated with the magnitude of tobacco consumption (current number of cigarettes/day and number of packs/year). Accordingly, current tobacco users had significantly higher plasma BDNF levels than non-users. In further studies of MDD, peripheral measures of BDNF should take into account tobacco use.
authors: INSERM UMR 1178, University Paris Sud, Service de Psychiatrie, Hôpital Bicêtre, Assistance Publique-Hôpitaux de Paris, Le Kremlin Bicêtre, France.
authors: Romain
authors: R
authors: Colle
authors: INSERM 1185, Faculty of Medicine Paris Sud, University Paris-Saclay, Le Kremlin-Bicêtre, F-94276, France, Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Hôpital de Bicêtre, Service de Génétique Moléculaire, Pharmacogénétique et Hormonologie, Le Kremlin Bicêtre F-94275, France.
authors: Séverine
authors: S
authors: Trabado
authors: INSERM UMR 1178, University Paris Sud, Service de Psychiatrie, Hôpital Bicêtre, Assistance Publique-Hôpitaux de Paris, Le Kremlin Bicêtre, France.
authors: Samuel
authors: S
authors: Rotenberg
authors: INSERM 1185, Faculty of Medicine Paris Sud, University Paris-Saclay, Le Kremlin-Bicêtre, F-94276, France, Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Hôpital de Bicêtre, Service de Génétique Moléculaire, Pharmacogénétique et Hormonologie, Le Kremlin Bicêtre F-94275, France.
authors: Sylvie
authors: S
authors: Brailly-Tabard
authors: INSERM UMR 1178, Université Paris-Saclay, Univ. Paris-Sud, UVSQ, CESP, Département d'addictologie, Assistance Publique-Hôpitaux de Paris, Villejuif 94800, France.
authors: Amine
authors: A
authors: Benyamina
authors: INSERM UMR 1178, Université Paris-Saclay, Univ. Paris-Sud, UVSQ, CESP, Département d'addictologie, Assistance Publique-Hôpitaux de Paris, Villejuif 94800, France.
authors: Henri-Jean
authors: HJ
authors: Aubin
authors: INSERM UMR 1178, University Paris Sud, Service de Psychiatrie, Hôpital Bicêtre, Assistance Publique-Hôpitaux de Paris, Le Kremlin Bicêtre, France.
authors: Patrick
authors: P
authors: Hardy
authors: INSERM UMR 1178, CESP, Département de Biostatistiques, University Paris Sud, Hôpital Paul Brousse, Assistance Publique Hôpitaux de Paris, 94400 Villejuif, France.
authors: Bruno
authors: B
authors: Falissard
authors: University Paris Sud, EA 4123, Service de Génétique Moléculaire, Pharmacogénétique et Hormonologie, Hôpital Bicêtre, Assistance Publique-Hôpitaux de Paris, Le Kremlin Bicêtre, France, University Paris-Sud, EA4123 Chatenay-Malabry, France.
authors: Laurent
authors: L
authors: Becquemont
authors: University Paris Sud, EA 4123, Service de Génétique Moléculaire, Pharmacogénétique et Hormonologie, Hôpital Bicêtre, Assistance Publique-Hôpitaux de Paris, Le Kremlin Bicêtre, France, University Paris-Sud, EA4123 Chatenay-Malabry, France.
authors: Céline
authors: C
authors: Verstuyft
authors: Endocrinology Unit, Hôpital Saint-Antoine, Assistance Publique Hôpitaux de Paris, Paris, France; Sobonne Universities, University Paris 6, INSERM UMR S_938, Centre de Recherche Saint-Antoine, Paris, France.
authors: Bruno
authors: B
authors: Fève
authors: INSERM UMR 1178, University Paris Sud, Service de Psychiatrie, Hôpital Bicêtre, Assistance Publique-Hôpitaux de Paris, Le Kremlin Bicêtre, France. Electronic address: Emmanuelle.corruble@aphp.fr.
authors: Emmanuelle
authors: E
authors: Corruble
mesh_terms: D000328:Adult; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood*; D003865:Major Depressive Disorder / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012907:Smoking / Q000097:blood* / Q000503:physiopathology
chemical_list: D019208:Brain-Derived Neurotrophic Factor; C579455:BDNF protein, human