title: Exercise capacity following a percutaneous endoscopic gastrostomy in a young female with cystic fibrosis: a case report.
abstract: Cystic fibrosis (CF) is a genetic condition affecting the respiratory and gastrointestinal systems, with patients experiencing problems maintaining weight, especially during rapid growth periods such as puberty. The aim of this case report was to monitor the effect of gastrostomy insertion and implementation of overnight supplemental feeding upon clinical outcomes, including body mass index (BMI), lung function (FEV1), and exercise-related variables (maximal oxygen uptake [VO2max] and ventilatory efficiency [VE/VO2]) in an 11-year-old female with CF Combined incremental and supramaximal exercise testing to exhaustion was performed at four time points: 3 months prior to the procedure (T1), 2 days prior to (T2), 4 months (T3), and 1 year following the procedure (T4). Improvements following gastrostomy insertion were observed at the 1 year follow-up with regards to BMI (+20%); whereas absolute VO2maxremained stable and lung function fluctuated throughout the period of observation. Declines in function with regards to body weight relative VO2max(-16.3%) and oxygen uptake efficiency (+7.5%) were observed during this period. This case report is the first to consider exercise-related clinical outcomes in assessing the effect of implementing gastrostomy feeding in CF The varied direction and magnitude of the associations between variables shows that further investigations are required.
authors: Children's Health and Exercise Research Centre, Sport and Health Science University of Exeter, Exeter, U.K.|Royal Devon and Exeter NHS Foundation Trust Hospital, Exeter, U.K.
authors: Owen W
authors: OW
authors: Tomlinson
authors: Children's Health and Exercise Research Centre, Sport and Health Science University of Exeter, Exeter, U.K.
authors: Alan R
authors: AR
authors: Barker
authors: Royal Devon and Exeter NHS Foundation Trust Hospital, Exeter, U.K.
authors: Patrick J
authors: PJ
authors: Oades
authors: Children's Health and Exercise Research Centre, Sport and Health Science University of Exeter, Exeter, U.K c.a.williams@exeter.ac.uk.|Royal Devon and Exeter NHS Foundation Trust Hospital, Exeter, U.K.
authors: Craig A
authors: CA
authors: Williams
mesh_terms: D015992:Body Mass Index; D001835:Body Weight / Q000502:physiology*; D002648:Child; D003550:Cystic Fibrosis / Q000150:complications* / Q000178:diet therapy / Q000601:surgery; D004724:Endoscopy / Q000009:adverse effects* / Q000379:methods; D004750:Enteral Nutrition / Q000009:adverse effects* / Q000379:methods; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D005774:Gastrostomy / Q000009:adverse effects* / Q000379:methods; D006801:Humans; D009748:Nutrition Disorders / Q000209:etiology / Q000601:surgery*; D017063:Outcome Assessment, Health Care; D012129:Respiratory Function Tests / Q000379:methods
keywords: Adolescence; exercise testing; respiratory disease; risk factors