title: Heat FLiPs a Hormonal Switch for Longevity.
abstract: Temperature-sensing neurons in C. elegans reduce the life-shortening effects of high temperatures via steroid signaling. In this issue of Developmental Cell, Chen et al. (2016) elucidate the underlying mechanisms by which the transcription factor CREB induces the neuropeptide FLP-6 in the temperature-sensing neurons to counteract the life-shortening effects of high temperature.
authors: Department of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk, South Korea.
authors: Murat
authors: M
authors: Artan
authors: Department of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk, South Korea.
authors: Seon Woo A
authors: SW
authors: An
authors: Department of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk, South Korea; School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, Pohang, Gyeongbuk, South Korea. Electronic address: seungjaelee@postech.ac.kr.
authors: Seung-Jae V
authors: SV
authors: Lee
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans; D029742:Caenorhabditis elegans Proteins; D006358:Hot Temperature; D008136:Longevity; D014157:Transcription Factors
chemical_list: D029742:Caenorhabditis elegans Proteins; D014157:Transcription Factors