title: Polarization and asymmetry in T cell metabolism.
abstract: T cell activation results in a rapidly proliferating T cell endowed with a metabolic phenotype necessary for growth and division. However, before the cell can proceed towards this burst of cell division a phase of quiescence occurs, during which the basic mechanisms governing regulation of metabolic reprograming are established. This review focuses on key cellular processes controlling early metabolic regulation and how these circuits of metabolic control dictate distinct cellular fates upon the first asymmetric division.
authors: Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
authors: Marcin M
authors: MM
authors: Kamiński
authors: Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
authors: Swantje
authors: S
authors: Liedmann
authors: Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
authors: Sandra
authors: S
authors: Milasta
authors: Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA. Electronic address: douglas.green@stjude.org.
authors: Douglas R
authors: DR
authors: Green
mesh_terms: D000818:Animals; D060049:Asymmetric Cell Division / Q000235:genetics / Q000276:immunology; D015415:Biomarkers; D004734:Energy Metabolism; D005786:Gene Expression Regulation; D006801:Humans; D008213:Lymphocyte Activation / Q000235:genetics / Q000276:immunology*; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism*
chemical_list: D015415:Biomarkers
keywords: Asymmetric cell division; Metabolism; Polarization; T cell activation; c-Myc