title: Biomimetic Design of Mussel-Derived Bioactive Peptides for Dual-Functionalization of Titanium-Based Biomaterials.
abstract: Specific cell adhesion and osteogenicity are both crucial factors for the long-term success of titanium implants. In this work, two mussel-derived bioactive peptides were designed to one-step dual-biofunctionalization of titanium implants via robust catechol/TiO2coordinative interactions. The highly biomimetic peptides capped with integrin-targeted sequence or osteogenic growth sequence could efficiently improve the biocompatibilities of titanium implants and endow the implants with abilities to induce specific cell adhesion and enhanced osteogenicity. More importantly, rationally combined use of the two biomimetic peptides indicated an enhanced synergism on osteogenicity, osseointegration and finally the mechanical stability of Ti implants in vivo. Therefore, the highly biomimetic mussel-derived peptides and the dual-functional strategy in this study would provide a facile, safe, and effective means for improving clinical outcome of titanium-based medical implants.
authors: Department of Orthopaedics, The First Affiliated Hospital of Soochow University, Orthopaedic Institute, Soochow University , 188 Shizi Street, Suzhou, Jiangsu 215006, China.
authors: Guoqing
authors: G
authors: Pan
authors: Department of Orthopaedics, The First Affiliated Hospital of Soochow University, Orthopaedic Institute, Soochow University , 188 Shizi Street, Suzhou, Jiangsu 215006, China.
authors: Shujin
authors: S
authors: Sun
authors: Department of Orthopaedics, The First Affiliated Hospital of Soochow University, Orthopaedic Institute, Soochow University , 188 Shizi Street, Suzhou, Jiangsu 215006, China.
authors: Wen
authors: W
authors: Zhang
authors: Department of Chemistry, University of California , Irvine, California 92697, United States.
authors: Ruobing
authors: R
authors: Zhao
authors: Department of Orthopaedics, The First Affiliated Hospital of Soochow University, Orthopaedic Institute, Soochow University , 188 Shizi Street, Suzhou, Jiangsu 215006, China.
authors: Wenguo
authors: W
authors: Cui
authors: Department of Orthopaedics, The First Affiliated Hospital of Soochow University, Orthopaedic Institute, Soochow University , 188 Shizi Street, Suzhou, Jiangsu 215006, China.
authors: Fan
authors: F
authors: He
authors: Department of Orthopaedics, The First Affiliated Hospital of Soochow University, Orthopaedic Institute, Soochow University , 188 Shizi Street, Suzhou, Jiangsu 215006, China.
authors: Lixin
authors: L
authors: Huang
authors: Department of Chemistry, University of California , Irvine, California 92697, United States.
authors: Shih-Hui
authors: SH
authors: Lee
authors: Department of Chemistry, University of California , Irvine, California 92697, United States.
authors: Kenneth J
authors: KJ
authors: Shea
authors: Department of Orthopaedics, The First Affiliated Hospital of Soochow University, Orthopaedic Institute, Soochow University , 188 Shizi Street, Suzhou, Jiangsu 215006, China.
authors: Qin
authors: Q
authors: Shi
authors: Department of Orthopaedics, The First Affiliated Hospital of Soochow University, Orthopaedic Institute, Soochow University , 188 Shizi Street, Suzhou, Jiangsu 215006, China.
authors: Huilin
authors: H
authors: Yang
mesh_terms: D000818:Animals; D040761:Biomimetic Materials / Q000138:chemical synthesis* / Q000737:chemistry; D049872:Bivalvia / Q000737:chemistry*; D002448:Cell Adhesion; D049109:Cell Proliferation; D002478:Cells, Cultured; D006801:Humans; D015394:Molecular Structure; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D014025:Titanium / Q000737:chemistry*
chemical_list: D010455:Peptides; D014025:Titanium