title: Level of Alkenylbenzenes in Parsley and Dill Based Teas and Associated Risk Assessment Using the Margin of Exposure Approach.
abstract: Risk assessment of parsley and dill based teas that contain alkenylbenzenes was performed. To this end the estimated daily intake (EDI) of alkenylbenzenes resulting from use of the teas was quantified. Since most teas appeared to contain more than one alkenylbenzene, a combined risk assessment was performed based on equal potency of all alkenylbenzenes or using a so-called toxic equivalency (TEQ) approach through defining toxic equivalency factors (TEFs) for the different alkenylbenzenes. The EDI values resulting from consuming one cup of tea a day were 0.2-10.1 μg/kg bw for the individual alkenylbenzenes, 0.6-13.1 μg/kg bw for the sum of the alkenylbenzenes, and 0.3-10.7 μg safrole equiv/kg bw for the sum of alkenylbenzenes when expressed in safrole equivalents. The margin of exposure (MOE) values obtained were generally <10000, indicating a concern if the teas would be consumed on a daily basis over longer periods of time.
authors: Aqaba International Laboratories/BENHAYYAN , ASEZA, Aqaba 77110, Jordan.|Division of Toxicology, Wageningen University , Stippeneng 4, 6708 WE Wageningen, The Netherlands.
authors: Abdalmajeed M
authors: AM
authors: Alajlouni
authors: Aqaba International Laboratories/BENHAYYAN , ASEZA, Aqaba 77110, Jordan.|Division of Toxicology, Wageningen University , Stippeneng 4, 6708 WE Wageningen, The Netherlands.
authors: Amer J
authors: AJ
authors: Al-Malahmeh
authors: Division of Toxicology, Wageningen University , Stippeneng 4, 6708 WE Wageningen, The Netherlands.
authors: Farida Nur
authors: FN
authors: Isnaeni
authors: Division of Toxicology, Wageningen University , Stippeneng 4, 6708 WE Wageningen, The Netherlands.
authors: Sebastiaan
authors: S
authors: Wesseling
authors: Laboratory of Biochemistry, Wageningen University , Stippeneng 4, 6708 WE Wageningen, The Netherlands.
authors: Jacques
authors: J
authors: Vervoort
authors: Division of Toxicology, Wageningen University , Stippeneng 4, 6708 WE Wageningen, The Netherlands.
authors: Ivonne M C M
authors: IM
authors: Rietjens
mesh_terms: D028524:Anethum graveolens / Q000737:chemistry*; D001554:Benzene / Q000737:chemistry* / Q000633:toxicity; D006801:Humans; D028528:Petroselinum / Q000737:chemistry*; D018570:Risk Assessment; D013662:Tea / Q000737:chemistry / Q000633:toxicity
chemical_list: D013662:Tea; D001554:Benzene
keywords: alkenylbenzenes; estimated daily intake; margin of exposure; parsley and dill based teas; risk assessment; toxic equivalency factors