title: The role of steroid hormone supplementation in non-assisted reproductive technology treatments for unexplained infertility.
abstract: Fertility treatment strategies are evolving, with a more rapid transition to assisted reproductive technology (ART) treatments after unsuccessful non-ART treatments. This trend increases the potential importance of adjuvant treatments in non-ART cycles, such as steroid hormone supplementation. It has been established that success rates of ART treatments are increased with the use of luteal support with progesterone. In the setting of non-ART cycles, however, the evidence is less clear, and clinical practices vary widely between providers and clinics. In this review, we aimed to provide an overview of the current evidence for the use of steroid hormone supplementation, including progesterone for luteal support, estrogens, androgens, and mineralocorticoids, in the setting of non-ART treatments for ovulatory women.
authors: Section of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma. Electronic address: alexander-quaas@ouhsc.edu.
authors: Alexander M
authors: AM
authors: Quaas
authors: Section of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.
authors: Karl R
authors: KR
authors: Hansen
mesh_terms: D005260:Female; D005298:Fertility / Q000187:drug effects*; D005300:Fertility Agents, Female / Q000009:adverse effects / Q000627:therapeutic use*; D012739:Gonadal Steroid Hormones / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D007246:Infertility / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D011247:Pregnancy; D012307:Risk Factors; D016896:Treatment Outcome
chemical_list: D005300:Fertility Agents, Female; D012739:Gonadal Steroid Hormones
keywords: Unexplained infertility; intrauterine insemination; luteal supplementation; progesterone; steroid hormones