title: SREBF-2 polymorphism influences white matter microstructure in bipolar disorder.
abstract: The aim of the study is to investigate if gene polymorphisms in sterol regulatory element binding protein transcriptional factors SREBF-1 and SREBF-2, which regulate lipid and cholesterol metabolism, could affect white matter (WM) microstructure, the most recognized structural biomarker of bipolar disorder (BD). In a sample of 93 patients affected by BD, we investigated the effect of SREBF-1 rs11868035, and SREBF-2 rs1052717, on WM microstructure, using diffusion tensor imaging and tract-based spatial statistics. We observed increased radial diffusivity in the rs1052717 A/A genotype compared to A/G and G/G, and reduced fractional anisotropy (FA) in the rs1052717 A/A genotype compared to G carriers in cingulum, corpus callosum, superior and inferior longitudinal fasciculi, and anterior thalamic radiation. These results seem to suggest an involvement of SREBF-2 in the integrity of white matter tracts in BD and therefore a possible role of SREBP pathway in CNS myelination processes.
authors: Scientific Institute and University Vita-Salute San Raffaele, Department of Clinical Neurosciences, Milan, Italy; C.E.R.M.A.C. (Centro di Eccellenza Risonanza Magnetica ad Alto Campo), University Vita-Salute San Raffaele, Milan, Italy. Electronic address: poletti.sara@hsr.it.
authors: Sara
authors: S
authors: Poletti
authors: Scientific Institute and University Vita-Salute San Raffaele, Department of Clinical Neurosciences, Milan, Italy.
authors: Veronica
authors: V
authors: Aggio
authors: Scientific Institute and University Vita-Salute San Raffaele, Department of Clinical Neurosciences, Milan, Italy; C.E.R.M.A.C. (Centro di Eccellenza Risonanza Magnetica ad Alto Campo), University Vita-Salute San Raffaele, Milan, Italy; PhD program in Philosophy and Sciences of Mind; University Vita-Salute San Raffaele, Milan, Italy.
authors: Irene
authors: I
authors: Bollettini
authors: C.E.R.M.A.C. (Centro di Eccellenza Risonanza Magnetica ad Alto Campo), University Vita-Salute San Raffaele, Milan, Italy; Scientific Institute and University Vita-Salute San Raffaele, Department of Neuroradiology, Milan, Italy.
authors: Andrea
authors: A
authors: Falini
authors: Scientific Institute and University Vita-Salute San Raffaele, Department of Clinical Neurosciences, Milan, Italy.
authors: Cristina
authors: C
authors: Colombo
authors: Scientific Institute and University Vita-Salute San Raffaele, Department of Clinical Neurosciences, Milan, Italy; C.E.R.M.A.C. (Centro di Eccellenza Risonanza Magnetica ad Alto Campo), University Vita-Salute San Raffaele, Milan, Italy.
authors: Francesco
authors: F
authors: Benedetti
mesh_terms: D000328:Adult; D001714:Bipolar Disorder / Q000000981:diagnostic imaging / Q000235:genetics* / Q000473:pathology; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology*; D056324:Diffusion Tensor Imaging / Q000379:methods; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D051782:Sterol Regulatory Element Binding Protein 2 / Q000235:genetics*; D066127:White Matter / Q000000981:diagnostic imaging / Q000473:pathology*
chemical_list: C497390:SREBF2 protein, human; D051782:Sterol Regulatory Element Binding Protein 2
keywords: Bipolar disorder; Cholesterol; Myelination; Sterol regulatory element binding protein; White matter