title: Detection of PCT and urinary β2-MG enhances the accuracy for localization diagnosing pediatric urinary tract infection.
abstract: OBJECTIVE
  The purpose of this article was to investigate whether the combination of urinary beta 2 microglobulin (urinary β2-MG) and procalcitonin (PCT) diagnosis could enhance the localization diagnostic precision of pediatric urinary tract infection comparing with single diagnosis.
  
  
  METHODS
  A study was conducted in the Nephrology Department of Wuhan women and children's health care centre. This study incorporated 85 participants, including 35 children who were diagnosed as upper urinary tract infection (UUTI) with the symptom of fever and 50 children who conducted lower urinary tract infection (LUTI). Levels of PCT and urinary β2-MG in both UUTI and LUTI patients were measured and compared.
  
  
  RESULTS
  The level of PCT and β2-MG were both significantly higher in UUTI group compared with in LUTI group. AUC of urinary β2-MG ROC (sensitivity of 71.4%, specificity of 90.0%) was significantly smaller than that of PCT ROC (sensitivity of 77.1%, specificity of 96.0%) in the single diagnosis. Although in the combined diagnosis, the sensitivity and specificity increased to 88.6% and 98%, respectively.
  
  
  CONCLUSIONS
  Both PCT and β2-MG could be used to localize the UTI. Introducing urinary β2-MG into PCT diagnosis could increase the sensitivity and specificity of UTI lesion diagnosis in clinical practice.
authors: Department of Nephrology, Wuhan Women and Children's Health Care Center, Wuhan, Hubei, China.
authors: Jian
authors: J
authors: Fang
authors: Department of Nephrology, Wuhan Women and Children's Health Care Center, Wuhan, Hubei, China.
authors: Jiangwei
authors: J
authors: Luan
authors: Department of Nephrology, Wuhan Women and Children's Health Care Center, Wuhan, Hubei, China.
authors: Gaohong
authors: G
authors: Zhu
authors: Department of Nephrology, Wuhan Women and Children's Health Care Center, Wuhan, Hubei, China.
authors: Chang
authors: C
authors: Qi
authors: Department of Cardiovascular Medicine, Wuhan Women and Children's Health Care Center, Wuhan, Hubei, China.
authors: Dandan
authors: D
authors: Wang
mesh_terms: D000293:Adolescent; D002116:Calcitonin / Q000652:urine*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D012372:ROC Curve; D012680:Sensitivity and Specificity; D014552:Urinary Tract Infections / Q000145:classification / Q000175:diagnosis* / Q000652:urine*; D001613:beta 2-Microglobulin / Q000652:urine*
chemical_list: D001613:beta 2-Microglobulin; D002116:Calcitonin
keywords: children; localization diagnosis; procalcitonin; urinary tract infection; urinary β2-MG