title: Cerebellar and Spinal Direct Current Stimulation in Children: Computational Modeling of the Induced Electric Field.
abstract: Recent studies have shown that the specific application of transcranial direct current stimulation (tDCS) over the cerebellum can modulate cerebellar activity. In parallel, transcutaneous spinal DC stimulation (tsDCS) was found to be able to modulate conduction along the spinal cord and spinal cord functions. Of particular interest is the possible use of these techniques in pediatric age, since many pathologies and injuries, which affect the cerebellar cortex as well as spinal cord circuits, are diffuse in adults as well as in children. Up to now, experimental studies of cerebellar and spinal DC stimulation on children are completely missing and therefore there is a lack of information about the safety of this technique as well as the appropriate dose to be used during the treatment. Therefore, the knowledge of electric quantities induced into the cerebellum and over the spinal cord during cerebellar tDCS and tsDCS, respectively, is required. This work attempts to address this issue by estimating through computational techniques, the electric field distributions induced in the target tissues during the two stimulation techniques applied to different models of children of various ages and gender. In detail, we used four voxel child models, aged between 5- and 8-years. Results revealed that, despite inter-individual differences, the cerebellum is the structure mainly involved by cerebellar tDCS, whereas the electric field generated by tsDCS can reach the spinal cord also in children. Moreover, it was found that there is a considerable spread toward the anterior area of the cerebellum and the brainstem region for cerebellar tDCS and in the spinal nerve for spinal direct current stimulation. Our study therefore predicts that the electric field spreads in complex patterns that strongly depend on individual anatomy, thus giving further insight into safety issues and informing data for pediatric investigations of these stimulation techniques.
authors: Istituto di Elettronica e di Ingegneria dell'Informazione e delle Telecomunicazioni (IEIIT), Consiglio Nazionale delle Ricerche (CNR) Milan, Italy.
authors: Serena
authors: S
authors: Fiocchi
authors: Istituto di Elettronica e di Ingegneria dell'Informazione e delle Telecomunicazioni (IEIIT), Consiglio Nazionale delle Ricerche (CNR) Milan, Italy.
authors: Paolo
authors: P
authors: Ravazzani
authors: Dipartimento di Scienze della Salute, Ospedale San Paolo, Università degli Studi di Milano Milan, Italy.
authors: Alberto
authors: A
authors: Priori
authors: Istituto di Elettronica e di Ingegneria dell'Informazione e delle Telecomunicazioni (IEIIT), Consiglio Nazionale delle Ricerche (CNR) Milan, Italy.
authors: Marta
authors: M
authors: Parazzini
keywords: children; computational modeling; ctDCS; high-resolution human models; neuromodulation; tsDCS