title: Prothrombin and factor X are elevated in multiple sclerosis patients.
abstract: Animal models have implicated an integral role for coagulation factors in neuroinflammatory diseases such as multiple sclerosis (MS) beyond their role in hemostasis. However, their relevance in humans requires further elucidation. This study aimed to determine whether levels of coagulation factors differ between patients with neuroimmunological disorders and respective controls. Individuals suffering from relapsing-remitting and secondary progressive MS had significantly higher prothrombin and factor X levels than healthy donors, whereas levels were unchanged in primary progressive MS and neuromyelitis optica patients. Our study demonstrates that coagulation factors may be key mediators in neuroinflammation and may therefore provide future targets for therapeutic strategies. Ann Neurol 2016;80:946-951.
authors: Department of Neurology, University of Münster, Münster.
authors: Kerstin
authors: K
authors: Göbel
authors: Department of Neurology, University Hospital Würzburg, Würzburg.
authors: Peter
authors: P
authors: Kraft
authors: Department of Neurology, University of Münster, Münster.
authors: Susann
authors: S
authors: Pankratz
authors: Department of Neurology, University of Münster, Münster.
authors: Catharina C
authors: CC
authors: Gross
authors: Department of Neurology, University of Münster, Münster.
authors: Catharina
authors: C
authors: Korsukewitz
authors: Institute of Biostatistics and Clinical Research, University of Münster, Münster.
authors: Robert
authors: R
authors: Kwiecien
authors: Department of Medicine A, University Hospital Münster, Münster.
authors: Rolf
authors: R
authors: Mesters
authors: Department of Anesthesiology, Intensive Care, and Pain Medicine, Experimental and Clinical Hemostasis, University of Münster, Münster.
authors: Beate E
authors: BE
authors: Kehrel
authors: Department of Neurology, University of Münster, Münster.
authors: Heinz
authors: H
authors: Wiendl
authors: Department of Neurology, University Hospital Würzburg, Würzburg.|Department of Neurology, University Hospital Essen, Essen, Germany.
authors: Christoph
authors: C
authors: Kleinschnitz
authors: Department of Neurology, University of Münster, Münster.
authors: Sven G
authors: SG
authors: Meuth
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001779:Blood Coagulation Factors / Q000378:metabolism; D016022:Case-Control Studies; D005170:Factor X / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020528:Multiple Sclerosis, Chronic Progressive / Q000097:blood*; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000097:blood*; D009471:Neuromyelitis Optica / Q000097:blood; D011516:Prothrombin / Q000378:metabolism*; D055815:Young Adult
chemical_list: D001779:Blood Coagulation Factors; D011516:Prothrombin; D005170:Factor X