title: Repeatability of magnetic resonance fingerprinting T1and T2estimates assessed using the ISMRM/NIST MRI system phantom.
abstract: The purpose of this study was to evaluate accuracy and repeatability of T1and T2estimates of a MR fingerprinting (MRF) method using the ISMRM/NIST MRI system phantom.
  
  
  
  The ISMRM/NIST MRI system phantom contains multiple compartments with standardized T1, T2, and proton density values. Conventional inversion-recovery spin echo and spin echo methods were used to characterize the T1and T2values in the phantom. The phantom was scanned using the MRF-FISP method over 34 consecutive days. The mean T1and T2values were compared with the values from the spin echo methods. The repeatability was characterized as the coefficient of variation of the measurements over 34 days.
  
  
  
  T1and T2values from MRF-FISP over 34 days showed a strong linear correlation with the measurements from the spin echo methods (R2= 0.999 for T1; R2= 0.996 for T2). The MRF estimates over the wide ranges of T1and T2values have less than 5% variation, except for the shortest T2relaxation times where the method still maintains less than 8% variation.
  
  
  
  MRF measurements of T1and T2are highly repeatable over time and across wide ranges of T1and T2values. Magn Reson Med 78:1452-1457, 2017. © 2016 International Society for Magnetic Resonance in Medicine.
authors: Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA.
authors: Yun
authors: Y
authors: Jiang
authors: Department of Radiology, Case Western Reserve University, Cleveland, Ohio, USA.
authors: Dan
authors: D
authors: Ma
authors: Physical Measurement Laboratory, National Institute of Standards and Technology, Boulder, Colorado, USA.
authors: Kathryn E
authors: KE
authors: Keenan
authors: Physical Measurement Laboratory, National Institute of Standards and Technology, Boulder, Colorado, USA.
authors: Karl F
authors: KF
authors: Stupic
authors: Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA.|Department of Radiology, Case Western Reserve University, Cleveland, Ohio, USA.
authors: Vikas
authors: V
authors: Gulani
authors: Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA.|Department of Radiology, Case Western Reserve University, Cleveland, Ohio, USA.
authors: Mark A
authors: MA
authors: Griswold
mesh_terms: D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000295:instrumentation* / Q000379:methods*; D010363:Pattern Recognition, Automated; D019047:Phantoms, Imaging
keywords: MR fingerprinting; NIST system phantom; quantitative imaging; relaxation time; repeatability