title: 18F-fludrodeoxyglucose maximal standardized uptake value and metabolic tumor burden are associated with major chemotherapy-related tumor markers in NSCLC patients.
abstract: OBJECTIVE
  Metabolic activity and tumor burden are significant for prognosis and metastasis of non-small cell lung cancer (NSCLC), including maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG). Chemotherapy resistance is a great challenge for treating NSCLC patients and is also closely related with several biomarkers such as epidermal growth factor receptor (EGFR), p53, and excision repair cross-complementing group 1 protein (ERCC1). Our purpose was to determine the correlation between positron emission tomography/computed tomography (PET/CT) parameters and tumor markers-related chemotherapy resistance in NSCLC.
  
  
  METHODS
  Forty-six NSCLC chemotherapy-naïve patients were enrolled. The SUVmax, MTV, and TLG were calculated by PET/CT imaging, and expression of EGFR, p53, and ERCC1 were analyzed by immunohistochemistry on tissues. SUVmax, MTV, and TLG compared for their performance in predicting the expression of EGFR, p53, and ERCC1 were illustrated with statistical analysis.
  
  
  RESULTS
  SUVmaxwas significantly correlated with p53 expression (P=0.001), and MTV and TLG were significantly associated with ERCC1 (P=0.000;P=0.000). Furthermore, multiple stepwise regression analysis revealed that SUVmaxwas the primary predictor for p53, MTV and TLG was the primary predictor for ERCC1. SUVmaxhad a sensitivity of 91% and specificity of 50% for the detection of p53 positive. The sensitivities of MTV and TLG were 83% and 80%, and specificities were 69% and 75% for the detection of ERCC1 positive, respectively. When we suggested p53 or ERCC1 positive, the cutoff value of SUVmax, MTV, and TLG were 7.68, 23.62, and 129.65 cm3, respectively.
  
  
  CONCLUSIONS
  SUVmax, MTV, and TLG were closely associated with p53 and ERCC1' expressions. Therefore,18F-fludrodeoxyglucose PET/CT could be a new way of predicting p53 or ERCC1-related chemotherapy effect in NSCLC patients with more convenience.
authors: Department of Medical Imaging.
authors: Lu
authors: L
authors: Bai
authors: Department of Orthopedics.
authors: Chihua
authors: C
authors: Guo
authors: Department of Oncological Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, People's Republic of China.
authors: Jiansheng
authors: J
authors: Wang
authors: Department of Medical Imaging.
authors: Xiang
authors: X
authors: Liu
authors: Department of Medical Imaging.
authors: Yang
authors: Y
authors: Li
authors: Department of Medical Imaging.
authors: Miao
authors: M
authors: Li
authors: Department of Orthopedics.
authors: Youmin
authors: Y
authors: Guo
authors: Department of Orthopedics.
authors: Xiaoyi
authors: X
authors: Duan
keywords: 18F-fludrodeoxyglucose; maximal standardized uptake values; metabolic tumor volume; non-small cell lung cancer; total lesion glycolysis; tumor markers