title: Clinical outcomes for patients after surgery and radiation therapy for mesenchymal chondrosarcomas.
abstract: BACKGROUND
  We report the outcome of 23 patients with mesenchymal chondrosarcomas treated with surgery and radiation therapy +/- chemotherapy. The intent of the project was to review the impact of patient and treatment variables on treatment outcome, in particular with regard to extent of surgery and radiation dose.
  
  
  METHODS
  Twenty-three patients with mesenchymal chondrosarcomas were treated with surgery and radiation therapy (min. dose 44 Gy; max. dose 78 Gy; median dose 60 Gy; mean dose 61 Gy).
  
  
  RESULTS
  The median survival for the entire cohort of patients was 21.65 years (95% confidence interval ± 4.25). The 5- and 10-year OS was 78.6%. Median disease-free survival for the 23 patients was 7.2 years. Disease-free survival (DFS) at 3 and 5 years was 70.7% and 57.8%, respectively. The local control rate at 5 and 10 years was 89.5% (95%CI 64.1-97.3%). Only three patients experienced local failure, three patients had regional failure, and eight developed distant metastases.
  
  
  CONCLUSIONS
  In this cohort of patients local tumor control was high when using a combination of surgery and radiation. There was not a clear relationship between radiation dose and local tumor control. J. Surg. Oncol. 2016;114:982-986. © 2016 Wiley Periodicals, Inc.
authors: Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
authors: Karen
authors: K
authors: De Amorim Bernstein
authors: Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
authors: Norbert
authors: N
authors: Liebsch
authors: Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
authors: Yen-Lin
authors: YL
authors: Chen
authors: Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
authors: Andrzej
authors: A
authors: Niemierko
authors: Department of Orthopedic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
authors: Joseph H
authors: JH
authors: Schwab
authors: Department of Orthopedic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
authors: Kevin
authors: K
authors: Raskin
authors: Department of Orthopedic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
authors: Santiago A
authors: SA
authors: Lozano-Calderon
authors: Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
authors: Gregory
authors: G
authors: Cote
authors: Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
authors: David C
authors: DC
authors: Harmon
authors: Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
authors: Edwin
authors: E
authors: Choy
authors: Department of General Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
authors: Alex
authors: A
authors: Haynes
authors: Department of General Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
authors: John
authors: J
authors: Mullen
authors: Department of Orthopedic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
authors: Francis J
authors: FJ
authors: Hornicek
authors: Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
authors: Thomas F
authors: TF
authors: DeLaney
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols; D001859:Bone Neoplasms / Q000401:mortality / Q000532:radiotherapy* / Q000601:surgery*; D017024:Chemotherapy, Adjuvant; D002648:Child; D002675:Child, Preschool; D018211:Chondrosarcoma, Mesenchymal / Q000188:drug therapy / Q000401:mortality / Q000532:radiotherapy* / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011879:Radiotherapy Dosage; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome; D055815:Young Adult
keywords: chemotherapy; management; mesenchymal chondrosarcomas; radiation therapy; surgery