title: Different Efficiency of Liposomal Forms with Hydrophilic and Hydrophobic Antitumor Agents in Relation to Solid Transplants of Mouse Tumor and Its Metastases in the Liver.
abstract: Experiments were performed on the model of transplanted mouse tumor with high incidence of liver metastases. Hydrophilic drug cycloplatam (injected intravenously in liposomes) was more potent than "free cycloplatam" (injected intravenously or intraperitoneally in physiological saline) in inhibiting the growth of natural and experimental metastases in the liver. By contrast, liposomal cycloplatam had lower efficiency than free cycloplatam in suppressing the growth of solid tumor. Liposomal and free cortifen (hydrophobic hormonal cytostatic) produced nearly the same effects on solid tumor growth. Our results suggest that liposomal forms of hydrophobic compounds producing nonselective effect on tumor cells (e.g., actinomycin D or Cosmegen), should not have advantages over free forms.
authors: Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia. pathol@inbox.ru.|Novosibirsk National Research University, Novosibirsk, Russia. pathol@inbox.ru.
authors: N A
authors: NA
authors: Popova
authors: Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
authors: V I
authors: VI
authors: Kaledin
authors: Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
authors: V P
authors: VP
authors: Nikolin
authors: Institute of Molecular Pathology and Pathomorphology, Novosibirsk, Russia.
authors: L A
authors: LA
authors: Bogdanova
authors: Institute of Molecular Pathology and Pathomorphology, Novosibirsk, Russia.
authors: T S
authors: TS
authors: Morozkova
authors: Institute of Molecular Pathology and Pathomorphology, Novosibirsk, Russia.
authors: Yu V
authors: YV
authors: Tornuev
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000493:pharmacokinetics / Q000494:pharmacology*; D045744:Cell Line, Tumor; D003345:Corticosterone / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000494:pharmacology; D016503:Drug Delivery Systems; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D008081:Liposomes / Q000737:chemistry / Q000493:pharmacokinetics; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000556:secondary; D051379:Mice; D019042:Muscle Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D009368:Neoplasm Transplantation; D009588:Nitrogen Mustard Compounds / Q000493:pharmacokinetics / Q000494:pharmacology*; D009944:Organoplatinum Compounds / Q000493:pharmacokinetics / Q000494:pharmacology*; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D008081:Liposomes; D009588:Nitrogen Mustard Compounds; D009944:Organoplatinum Compounds; C058175:cortifen; C055928:cycloplatam; D003345:Corticosterone
keywords: cortifen; cycloplatam; liposomes; liver metastases; transplanted GA-1 tumor