title: The role of variants regulating metformin transport and action in women with polycystic ovary syndrome.
abstract: OBJECTIVE
  Variants in genes encoding metformin transport proteins and the ATM gene are associated with metformin response. We hypothesized that these gene variants contribute to variable metformin treatment response in polycystic ovary syndrome.
  
  
  METHODS
  The discovery cohort (n = 38) was studied in an open-label study. Results were replicated in two additional cohorts (n = 26 and n = 131). Response was assessed after 3-6 months of treatment with metformin extended-release 1500-2000 mg/day.
  
  
  RESULTS
  The rs683369 variant was associated with less weight loss in the discovery cohort (p = 0.003), but these results were not replicated (p = 0.8). There were no differences in glucose parameters, testosterone levels or ovulatory frequency as a function of genotype.
  
  
  CONCLUSIONS
  Variants in organic ion transporters do not explain the variable metformin response in polycystic ovary syndrome.
authors: Reproductive Endocrine Unit, Massachusetts General Hospital, Boston, MA 02114, USA.
authors: Cindy T
authors: CT
authors: Pau
authors: Departments of Obstetrics & Gynecology, Internal Medicine & Human & Molecular Genetics, Virginia Commonwealth University, Richmond, VA 23298, USA.
authors: Kai I
authors: KI
authors: Cheang
authors: Departments of Obstetrics & Gynecology, Internal Medicine & Human & Molecular Genetics, Virginia Commonwealth University, Richmond, VA 23298, USA.
authors: Bhavi P
authors: BP
authors: Modi
authors: Reproductive Endocrine Unit, Massachusetts General Hospital, Boston, MA 02114, USA.|VU University Medical Center, Amsterdam, The Netherlands.
authors: Thushiga
authors: T
authors: Kasippillai
authors: Reproductive Endocrine Unit, Massachusetts General Hospital, Boston, MA 02114, USA.
authors: Candace C
authors: CC
authors: Keefe
authors: Departments of Obstetrics & Gynecology, Internal Medicine & Human & Molecular Genetics, Virginia Commonwealth University, Richmond, VA 23298, USA.
authors: Maria
authors: M
authors: Shulleeta
authors: Division of Endocrinology, University of Virginia, Charlottesville, VA 22908, USA.
authors: William S
authors: WS
authors: Evans
authors: Department of Obstetrics & Gynecology, Yale University, New Haven, CT 06520, USA.
authors: Lubna
authors: L
authors: Pal
authors: Departments of Obstetrics & Gynecology, Internal Medicine & Human & Molecular Genetics, Virginia Commonwealth University, Richmond, VA 23298, USA.
authors: Jerome F
authors: JF
authors: Strauss
authors: Departments of Obstetrics & Gynecology, Internal Medicine & Human & Molecular Genetics, Virginia Commonwealth University, Richmond, VA 23298, USA.
authors: John E
authors: JE
authors: Nestler
authors: Reproductive Endocrine Unit, Massachusetts General Hospital, Boston, MA 02114, USA.|Division of Endocrinology, Metabolism & Diabetes, University of Utah, Salt Lake City, UT 84112, USA.
authors: Corrine K
authors: CK
authors: Welt
keywords: MATE; OCT; glucose; insulin; testosterone