title: Peculiarities of the Clinical Course of Oxidative Protein and Lipid Modification in Children with Acute Rheumatic Fever.
abstract: BACKGROUND
  Measuring indicators of oxidative protein and lipid metabolism is a diagnostic criterion of oxidative metabolism disruption at the early stages of chronic somatic pathology formation. Purpose was to assess the status of protein and lipid oxidative metabolism as a pathogenic link of acute rheumatic fever by measuring markers of early lesion.
  
  
  METHODS
  Research included measurement of lipid peroxidation products and efficiency of antioxidant protection.
  
  
  RESULTS
  It revealed unidirectional changes that confirm significant cellular membrane lesion. Determined changes correlated with the activity level of the pathological process while comparing the indicators of ill children in remission and during exacerbation. It was found that despite the active traditional treatment in hospitals for in-patients, a number of studied indicators did not return to normal in remission. This shows the persistence of membrane destruction processes in the body, which supports the pathological process and requires an investigation of the lesion severity at the level of cell metabolism.
  
  
  CONCLUSIONS
  Determination of disruption in the oxidative metabolism system of lipids and proteins, and the presence of mitochondrial insufficiency signs are universal pathogenic mechanism that reflects the multifactorial nature of the lesion with acute rheumatic fever.
authors: Bibigul
authors: B
authors: Tukbekova
authors: Medicine, Karaganda State Medical University, 40 Gogol Str., Karaganda, Kazakhstan.
authors: Sandugash
authors: S
authors: Dyussenova
authors: Saule
authors: S
authors: Kizatova
authors: Tattigul
authors: T
authors: Kenzhetayeva
authors: Karlygash
authors: K
authors: Zhubanysheva
authors: Kulziya
authors: K
authors: Zhaktayeva
authors: Saida
authors: S
authors: Sadvakassova
authors: Gulmira
authors: G
authors: Serikova
authors: Nazym
authors: N
authors: Yerimbetova
authors: Aiman
authors: A
authors: Issayeva
mesh_terms: D000975:Antioxidants / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism; D002648:Child; D018450:Disease Progression; D005260:Female; D006331:Heart Diseases / Q000150:complications / Q000378:metabolism; D006801:Humans; D050356:Lipid Metabolism; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000502:physiology*; D011237:Predictive Value of Tests; D011379:Prognosis; D011506:Proteins / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism; D012213:Rheumatic Fever / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism*
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D011506:Proteins; D017382:Reactive Oxygen Species; D008315:Malondialdehyde
keywords: Antioxidant; children; lipid peroxidation; pediatrics; protein modification.