title: Synthesis of a Water-soluble Metal-Organic Complex Array.
abstract: We demonstrate a method for the synthesis of a water-soluble multimetallic peptidic array containing a predetermined sequence of metal centers such as Ru(II), Pt(II), and Rh(III). The compound, named as a water-soluble metal-organic complex array (WSMOCA), is obtained through 1) the conventional solution-chemistry-based preparation of the corresponding metal complex monomers having a 9-fluorenylmethyloxycarbonyl (Fmoc)-protected amino acid moiety and 2) their sequential coupling together with other water-soluble organic building units on the surface-functionalized polymeric resin by following the procedures originally developed for the solid-phase synthesis of polypeptides, with proper modifications. Traces of reactions determined by mass spectrometric analysis at the representative coupling steps in stage 2 confirm the selective construction of a predetermined sequence of metal centers along with the peptide backbone. The WSMOCA cleaved from the resin at the end of stage 2 has a certain level of solubility in aqueous media dependent on the pH value and/or salt content, which is useful for the purification of the compound.
authors: International Center for Materials Nanoarchitectonics, National Institute for Materials Science.
authors: Purnandhu
authors: P
authors: Bose
authors: International Center for Materials Nanoarchitectonics, National Institute for Materials Science.
authors: Pradip K
authors: PK
authors: Sukul
authors: Department of Chemistry, University of California-Berkeley; Materials Sciences Division, Lawrence Berkeley National Laboratory; Kavli Energy NanoSciences Institute at Berkeley, University of California-Berkeley.
authors: Omar M
authors: OM
authors: Yaghi
authors: International Center for Materials Nanoarchitectonics, National Institute for Materials Science; TASHIRO.Kentaro@nims.go.jp.
authors: Kentaro
authors: K
authors: Tashiro
mesh_terms: D000596:Amino Acids; D008670:Metals; D010455:Peptides; D012995:Solubility; D014867:Water
chemical_list: D000596:Amino Acids; D008670:Metals; D010455:Peptides; D014867:Water