title: Kinase-mediated signaling cascades in mood disorders and antidepressant treatment.
abstract: Kinase-mediated signaling cascades regulate a number of different molecular mechanisms involved in cellular homeostasis, and are viewed as one of the most common intracellular processes that are robustly dysregulated in the pathophysiology of mood disorders such as depression. Newly emerged, rapid acting antidepressants are able to achieve therapeutic improvement, possibly in part, through stimulating activity of kinase-dependent signaling pathways. Thus, advancements in our understanding of how kinases may contribute to development and treatment of depression seem crucial. However, current investigations are limited to a single or small number of kinases and are unable to detect novel kinases. Here, we review fast developing kinome profiling approaches that allow identification of multiple kinases and kinase network connections simultaneously, analyze technical limitation and challenges, and discuss their future applications to mood disorders and antidepressant treatment.
authors: a Department of Physiology and Pharmacology , Des Moines University , Des Moines , IA , USA.
authors: Li-Lian
authors: LL
authors: Yuan
authors: a Department of Physiology and Pharmacology , Des Moines University , Des Moines , IA , USA.
authors: Eric
authors: E
authors: Wauson
authors: a Department of Physiology and Pharmacology , Des Moines University , Des Moines , IA , USA.
authors: Vanja
authors: V
authors: Duric
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D006801:Humans; D019964:Mood Disorders / Q000188:drug therapy* / Q000201:enzymology; D011494:Protein Kinases / Q000187:drug effects* / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects* / Q000502:physiology
chemical_list: D000928:Antidepressive Agents; D011494:Protein Kinases
keywords: Fast-acting antidepressant; kinase inhibitor; kinome profiling; major depressive disorders; protein kinase