title: Gut-associated Lymphoid Tissue (GALT) Carcinoma or Dome Carcinoma?
abstract: The vast majority of colorectal carcinomas (CRCs) evolve from mucosa not associated to lymphoid tissues aggregates via the adenoma-carcinoma sequence or via the serrated pathway. Rarely CRCs evolve from gut mucosa associated to lymphoid tissue (GALT).
  
  
  
  Based on the presence of a circumscribed elevation in the colorectal mucosa, GALT carcinomas are also referred to as dome carcinomas (DC). Descriptions of the surface mucosa covering 21 GALT-CRCs appearing in pathological reports were reviewed.
  
  
  
  Three of the 21 GALT-CRCs fulfilled the criteria of dome carcinoma. Of the remaining 18 GALT-CRCs, nine were described as polypoid lesions, five as plaque-like lesions, two as sessile elevated lesions or mass, one as ulcerated and one as histological finding. Hence, only 14.3% (n=3) of the 21 GALT-CRCs displayed a dome configuration, whereas the majority, 85.7% (n=18), exhibited structures other than dome shapes at gross or at histologic examination.
  
  
  
  It becomes apparent that by using "dome" in addressing carcinomas in the colorectal mucosa, many cases of GALT carcinomas might be overlooked. Another drawback of using the "dome" nomenclature is that dome-like outlines may be detected in small metastatic tumors in the submucosa or in small colorectal carcinomas not arising from GALT mucosa. Instead, by using "GALT carcinoma", that is the histologic diagnosis in addressing these neoplasias, all cases of GALT-CRCs will be included.
authors: Department of Pathology, Karolinska Institute and University Hospital, Stockholm, Sweden Carlos.Rubio@ki.se.
authors: Carlos A
authors: CA
authors: Rubio
authors: Department of Medicine, Center for Digestive Diseases, Karolinska Institute and University Hospital, Stockholm, Sweden.
authors: Peter T
authors: PT
authors: Schmidt
mesh_terms: D015179:Colorectal Neoplasms / Q000473:pathology*; D006801:Humans; D008221:Lymphoid Tissue / Q000473:pathology*
keywords: Colorectal cancer; dome carcinoma; gut-associated lymphoid tissue