title: Synthesis of Amides with Remote Stereocenters by Catalytic Asymmetric γ-Alkynylation of α,β-Unsaturated Amides.
abstract: An iridium-catalyzed enantioselective hydroalkynylation of α,β-unsaturated amides was described. The selectivity of this reaction is distinct from that observed in many catalytic hydroalkynylations of α,β-unsaturated carbonyl compounds. It occurs selectively at the γ instead of the β position. Preliminary mechanistic studies suggest that the reaction proceeds through alkene isomerization followed by hydroalkynylation. This method provides a straightforward route for the synthesis of amides with a remote stereocenter at the γ position.
authors: Center of Basic Molecular Science (CBMS), Department of Chemistry, Tsinghua University , Beijing 100084, China.
authors: Zi-Xuan
authors: ZX
authors: Wang
authors: Center of Basic Molecular Science (CBMS), Department of Chemistry, Tsinghua University , Beijing 100084, China.
authors: Xiao-Yan
authors: XY
authors: Bai
authors: Center of Basic Molecular Science (CBMS), Department of Chemistry, Tsinghua University , Beijing 100084, China.
authors: Han-Chao
authors: HC
authors: Yao
authors: Center of Basic Molecular Science (CBMS), Department of Chemistry, Tsinghua University , Beijing 100084, China.
authors: Bi-Jie
authors: BJ
authors: Li