title: Prognostic value of plasma levels of HIF-1a and PGC-1a in breast cancer.
abstract: Cellular adaptive mechanisms are crucial for tumorigenesis and a common feature in solid tumor progression. Hypoxia-inducible factor-1α (HIF-1α) facilitates the biological response to hypoxia, advancing angiogenesis and metastatic potential of the tumor. The peroxisome proliferator-activated receptor γ coactivators 1α (PGC-1α) enhances mitochondrial biogenesis, favored by migratory/invasive cancer cells. We conducted a prospective, long-term follow up study to determine whether HIF-1α and PGC-1α can be implemented as predictive biomarker in breast cancer. HIF-1α and PGC-1α plasma concentrations were measured in patients and in healthy controls by enzyme linked immune sorbent assay. Breast cancer patients had significantly higher HIF-1α and PGC-1α levels, which correlated with clinicopathological features, overall with more aggressive cancer characteristics. Disease free and overall survival of breast cancer patients with high HIF-1α and PGC-1α were significantly poorer than in patients with low plasma levels. In multivariate analysis, high amount of PGC-1α showed independent prognostic value. Our data suggests that HIF-1α and PGC-1α may be promising, noninvasive, biomarkers with a high potential for future clinical implication to identify subgroups of patients with poorer prognosis and to indicate early, subclinical metastasis.
authors: Department of Breast Surgery, Yangpu Hospital, Tongji University School of Medicine, Shanghai, PR China.
authors: Feng-Feng
authors: FF
authors: Cai
authors: Department of Breast Surgery, Yangpu Hospital, Tongji University School of Medicine, Shanghai, PR China.
authors: Cheng
authors: C
authors: Xu
authors: Department of Central Laboratory, Yangpu Hospital, Tongji University School of Medicine, Shanghai, PR China.
authors: Xin
authors: X
authors: Pan
authors: Department of Breast Surgery, Yangpu Hospital, Tongji University School of Medicine, Shanghai, PR China.
authors: Lu
authors: L
authors: Cai
authors: Department of Breast Surgery, Yangpu Hospital, Tongji University School of Medicine, Shanghai, PR China.
authors: Xiao-Yan
authors: XY
authors: Lin
authors: Department of Molecular and Cellular Biology, School of Forensic Sciences, Xi'an Jiao Tong University Health Science Center, Xi'an, Shaanxi, PR China.
authors: Su
authors: S
authors: Chen
authors: Department of Oncology, Department of Internal Medicine, University Hospital of Basel, Basel, Switzerland.
authors: Ewelina
authors: E
authors: Biskup
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000097:blood / Q000378:metabolism* / Q000473:pathology*; D005260:Female; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000097:blood*; D008875:Middle Aged; D009367:Neoplasm Staging; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha / Q000097:blood*; D011379:Prognosis; D011446:Prospective Studies; D016019:Survival Analysis
chemical_list: C497442:HIF1A protein, human; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; C486497:PPARGC1A protein, human; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
keywords: ELISA; HIF-1α; PGC-1α; breast cancer; prognosis