title: PPARG-LYPLAL1Multi-Allelic Combination Associated with Obesity and Overweight in Mexican Adolescent Females.
abstract: We studied multi-loci variants to identify the contribution of six candidate genes (ADIPOQ, CDH13, LYPLAL1, MC4R, PPARGandPGC1A) in the development of obesity and overweight.
  
  
  
  We genotyped 404 chromosomes with eleven SNPs in Mexican female adolescents, who were subdivided into two groups (obesity-overweight and normal-weight) using the World Health Organization parameters. Genomic (800 chromosomes) and ancestral (208 chromosomes) controls were included to reduce the population bias. Anthropometric measurements, biochemical parameters, and caloric intake were obtained only in the groups of Mexican female adolescents.
  
  
  
  A positive genotype-phenotype association was found that involves the multi-allelic combination of three risk alleles (one inPPARGand two inLYPLAL1) with obesity and overweight (OR=3.1, P=.010). This combination also exhibited a significant association with waist circumference (P=.030) and triglycerides levels (P=.030). These associations were supported by a logistic regression analysis adjusted for several confounding variables.
  
  
  
  Our data suggest the joint participation ofPPARG-LYPLAL1genes in metabolic disorders development. Hence, these genes could act as potential biomarkers in obesity and overweight. Our findings underscore the complexity of metabolic disorders and provide evidence about the importance of multi-loci analysis to study complex diseases.
authors: Departamento de Toxicología, Cinvestav-IPN, México D.F., México.
authors: Esther Alhelí
authors: EA
authors: Hernández-Tobías
authors: Instituto Nacional de Salud Pública, INSP, Cuernavaca, Morelos, México.
authors: Luisa
authors: L
authors: Torres-Sánchez
authors: Laboratorio BIMODI (Biología Molecular Diagnóstica), Querétaro, Qro., México.
authors: Gino
authors: G
authors: Noris
authors: Laboratorio BIMODI (Biología Molecular Diagnóstica), Querétaro, Qro., México.
authors: Carla
authors: C
authors: Santana
authors: Departamento de Nutrición y Bioprogramación, Instituto Nacional de Perinatología, México, D.F., México.
authors: María Reyna
authors: MR
authors: Samano
authors: Laboratorio de Virología, Hospital Infantil de México Federico Gómez, México.
authors: José
authors: J
authors: Arellano-Galindo
authors: Servicio de Genética, Instituto Nacional de Rehabilitación, México.
authors: María de la Luz
authors: ML
authors: Arenas-Sordo
authors: Departamento de Toxicología, Cinvestav-IPN, México D.F., México; Department of Anthropology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
authors: Daniel
authors: D
authors: Brooks
authors: Departamento de Nutrición y Bioprogramación, Instituto Nacional de Perinatología, México, D.F., México.
authors: Ana Lilia
authors: AL
authors: Rodríguez-Ventura
authors: Departamento de Biomedicina Molecular, Cinvestav-IPN, México.
authors: Marco Antonio
authors: MA
authors: Meraz-Ríos
authors: Departamento de Toxicología, Cinvestav-IPN, México D.F., México.
authors: Rocío
authors: R
authors: Gómez
mesh_terms: D000293:Adolescent; D000483:Alleles; D015992:Body Mass Index; D005260:Female; D005838:Genotype; D006801:Humans; D008245:Lysophospholipase / Q000235:genetics*; D008297:Male; D017058:Mexican Americans / Q000235:genetics*; D008800:Mexico; D009765:Obesity / Q000208:ethnology* / Q000235:genetics; D050177:Overweight / Q000208:ethnology* / Q000235:genetics; D047495:PPAR gamma / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D055105:Waist Circumference
chemical_list: D047495:PPAR gamma; D008245:Lysophospholipase; C561408:LYPLAL1 protein, human
keywords: LYPLAL1; PPARG; ADIPOQ; MC4R; CDH13;; Mexico; Multi-allelic Combination; Obesity