title: [Seroprevalence of HBsAg in pregnant women in central Morocco].
abstract: Maternal-fetal transmission of hepatitis B virus (HBV) is a global public health problem leading to the implementation of strengthened prevention measures. Viral replication in HIV-positive mother, assessed based on HBeAg positivity and the rate of viral load, determines the contamination risk which is very important during perinatal period. Mothers with chronic HBV are a real reservoir of vertical transmission of this infection. This is a prospective investigation of 1120 pregnant Moroccan women aiming to study the seroprevalence of HBsAg which was 2.35%, in order to supply the national evidence on this topic. Among these HIV-positive women who were HBsAg positive, 79.1% were HBeAg negative and underwent molecular research that was positive in 89.4% of cases. Immunization of women of childbearing age is one of the major pillars of prevention of HBV vertical transmission. Only 2.4% of our patients were vaccinated. This highlights the role of screening during pregnancy, which should focus on raising awareness about the importance of immunization in HIV-negative women and of monitoring using molecular biology tools in HIV-positive mothers in order to establish an appropriate prophylactic treatment.
authors: Service de Microbiologie, Hôpital Militaire Moulay Ismail, Faculté de Médecine et de Pharmacie de Fès, Maroc.
authors: Mohammed
authors: M
authors: Sbiti
authors: Service de Microbiologie, Hôpital Militaire Moulay Ismail, Faculté de Médecine et de Pharmacie de Fès, Maroc.
authors: Hanane
authors: H
authors: Khalki
authors: Service de Microbiologie, Hôpital Militaire Moulay Ismail, Faculté de Médecine et de Pharmacie de Fès, Maroc.
authors: Imane
authors: I
authors: Benbella
authors: Pôle de Biologie et Pharmacie, Hôpital Militaire Moulay Ismail, Meknès, Maroc.
authors: Lhoussaine
authors: L
authors: Louzi
mesh_terms: D000293:Adolescent; D000328:Adult; D003430:Cross-Sectional Studies; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000453:epidemiology; D006509:Hepatitis B / Q000175:diagnosis* / Q000453:epidemiology / Q000517:prevention & control; D006514:Hepatitis B Surface Antigens / Q000097:blood*; D017325:Hepatitis B Vaccines / Q000008:administration & dosage; D006513:Hepatitis B e Antigens / Q000097:blood; D006801:Humans; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control; D008403:Mass Screening / Q000379:methods; D009018:Morocco / Q000453:epidemiology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000453:epidemiology / Q000821:virology*; D011446:Prospective Studies; D016036:Seroepidemiologic Studies; D019562:Viral Load; D055815:Young Adult
chemical_list: D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines; D006513:Hepatitis B e Antigens
keywords: HBsAg; prevention of HBV vertical transmission; seroprevalence; viral load