title: Transmission dynamics of two dengue serotypes with vaccination scenarios.
abstract: In this work we present a mathematical model that incorporates two Dengue serotypes. The model has been constructed to study both the epidemiological trends of the disease and conditions that allow coexistence in competing strains under vaccination. We consider two viral strains and temporary cross-immunity with one vector mosquito population. Results suggest that vaccination scenarios will not only reduce disease incidence but will also modify the transmission dynamics. Indeed, vaccination and cross immunity period are seen to decrease the frequency and magnitude of outbreaks but in a differentiated manner with specific effects depending upon the interaction vaccine and strain type.
authors: Instituto de Matemáticas, Universidad Nacional Autónoma de México, Boulevard Juriquilla No. 3001, Juriquilla, 76230, México.
authors: N L
authors: NL
authors: González Morales
authors: Departamento de Matemáticas Aplicadas y Sistemas, DMAS, Universidad Autónoma Metropolitana, Cuajimalpa, Av. Vasco de Quiroga 4871, Col. Santa Fe Cuajimalpa, Cuajimalpa de Morelos, 05300, México, D.F., México. Electronic address: maynunlop@gmail.com.
authors: M
authors: M
authors: Núñez-López
authors: Centro de Investigaciones sobre Enfermedades Infecciosas, Instituto Nacional de Salud Pública, Cuernavaca, Mexico.
authors: J
authors: J
authors: Ramos-Castañeda
authors: Instituto de Matemáticas, Universidad Nacional Autónoma de México, Boulevard Juriquilla No. 3001, Juriquilla, 76230, México.
authors: J X
authors: JX
authors: Velasco-Hernández
mesh_terms: D000818:Animals; D003715:Dengue / Q000276:immunology / Q000517:prevention & control / Q000635:transmission*; D053059:Dengue Vaccines; D003716:Dengue Virus / Q000276:immunology*; D006801:Humans; D008962:Models, Theoretical; D000072138:Mosquito Vectors; D065288:Serogroup
chemical_list: D053059:Dengue Vaccines
keywords: Dengue; Serotypes; Vaccine effects