title: Changes in Hemodynamic Response Patterns in Motor Cortices Measured by Task-Based Functional Magnetic Resonance Imaging in Patients With Moyamoya Disease.
abstract: OBJECTIVE
  We aimed to study the value of blood oxygen level-dependent functional magnetic resonance imaging (BOLD-fMRI) in assessing cerebral hemodynamic changes for moyamoya disease (MMD).
  
  
  METHODS
  We recruited 15 healthy volunteers, 15 patients with MMD without dyskinesia, and 30 patients with MMD who experienced paroxysmal limb dyskinesia. The BOLD-fMRI scans were obtained during grasping motions of the left or right hand. Hemodynamic response curves in the primary motor cortices were generated. Six response parameters including negative response time (Tnr), maximum signal intensity of negative response, time to peak, maximum peak arrival time, maximum signal intensity of positive response, and positive response time were measured.
  
  
  RESULTS
  The hemodynamic response curve in the primary motor cortices of MMD patients showed extended Tnr, prolonged positive response time, and delayed time to peak than those of the controls. The response curve showed longer Tnr and maximum peak arrival time in the primary motor cortices on the affected side of the dyskinesia group.
  
  
  CONCLUSIONS
  Blood oxygen level-dependent fMRI is an effective technique to assess hemodynamic changes in patients with MMD.
authors: From the *Department of Radiology, Affiliated Hospital of Academy of Military Medical Sciences, Beijing; †The Radiology Department, Affiliated Southwest Hospital, Third Military Medical University, Chongqing; ‡Department of Neurosurgery, Affiliated Hospital of Academy of Military Medical Sciences; and §Germany Siemens Healthcare, MR Collaborations NE Asia, Beijing, China.
authors: Peng-Gang
authors: PG
authors: Qiao
authors: Zhi-Wei
authors: ZW
authors: Zuo
authors: Cong
authors: C
authors: Han
authors: Juan
authors: J
authors: Zhou
authors: Hong-Tao
authors: HT
authors: Zhang
authors: Lian
authors: L
authors: Duan
authors: Tianyi
authors: T
authors: Qian
authors: Gong-Jie
authors: GJ
authors: Li
mesh_terms: D000328:Adult; D001931:Brain Mapping / Q000379:methods*; D005260:Female; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009044:Motor Cortex / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D009072:Moyamoya Disease / Q000503:physiopathology*; D011930:Reaction Time