title: Influence ofMDM2polymorphisms on squamous cell carcinoma susceptibility: a meta-analysis.
abstract: OBJECTIVE
  Controversial associations between single-nucleotide polymorphisms (rs2279744, rs937283, rs3730485) of theMDM2gene and the etiology of squamous cell carcinomas (SCCs) have been reported. This merits further comprehensive assessment.
  
  
  METHODS
  We systematically reviewed the available data and conducted an updated meta-analysis to evaluate the genetic effect ofMDM2polymorphisms in SCC susceptibility, using Stata/SE 12.0 software.
  
  
  RESULTS
  After screening, 7,987 SCC cases and 12,954 controls from 26 eligible case-control studies were enrolled. Overall, compared with the control group, a significantly increased SCC risk was observed for theMDM2rs2279744 polymorphism in the Asian population (test of association: odds ratio [OR] 1.12,P=0.027 for G vs T; OR 1.26,P=0.016 for GG vs TT; OR 1.25,P<0.001 for GG vs TT + TG; and OR 1.08,P=0.023 for carrier G vs T). In subgroup analysis by SCC type, a similarly increased esophageal SCC risk was detected (OR 1.19,P<0.001 for G vs T; OR 1.46,P<0.001 for GG vs TT; and OR 1.48,P=0.005 for GG vs TT + TG). Furthermore,MDM2-TP53double mutation was statistically associated with increased SCC susceptibility overall (OR 1.52,P=0.001), especially in the Asian population (OR 1.49,P=0.022). However, no significant difference between the control and case groups was obtained forMDM2rs937283 or rs3730485 under any genetic model (allP>0.05).
  
  
  CONCLUSIONS
  Our results highlight a positive association between the GG genotype ofMDM2rs2279744 polymorphism and an increased risk of esophageal SCC in the Asian population, which needs to be clarified by more large-scale studies.
authors: Department of Otorhinolaryngology Head and Neck Surgery, Tianjin Huanhu Hospital, Tianjin, People's Republic of China.
authors: Huanxin
authors: H
authors: Yu
authors: Department of Otorhinolaryngology Head and Neck Surgery, Tianjin Huanhu Hospital, Tianjin, People's Republic of China.
authors: Haiyan
authors: H
authors: Li
authors: Department of Otorhinolaryngology Head and Neck Surgery, Tianjin Huanhu Hospital, Tianjin, People's Republic of China.
authors: Jinling
authors: J
authors: Zhang
authors: Department of Otorhinolaryngology Head and Neck Surgery, Tianjin Huanhu Hospital, Tianjin, People's Republic of China.
authors: Gang
authors: G
authors: Liu
keywords: MDM2; SCC; SNP; meta-analysis