title: IL-6 serum levels are elevated in Parkinson's disease patients with fatigue compared to patients without fatigue.
abstract: To investigate the influence of interleukin-6 (IL-6) and soluble tumor necrosis factor receptors (sTNFR) in fatigued Parkinson's disease (PD) patients. Forty-four PD patients were evaluated, and fatigue was assessed with the Parkinson Fatigue Scale. Logistic regression analysis was used to evaluate the contribution of disease severity scores and cytokine levels on fatigue scores. A receiver operating characteristic (ROC) curve was used to evaluate the diagnostic values of IL-6 in fatigue. Fatigued PD patients had worse cognitive function and depressive symptoms. These patients had worse PD signs and symptoms, displayed more advanced stages of PD, and had greater functional dependence. There was a significant difference in IL-6 serum levels (p=0.026), but there was no difference in sTNFR levels. Total scores on the Unified Parkinson Disease Rating Scale (β=1.108; p=0.004) and IL-6 levels (β=12.843; p=0.020) were found to be significant predictors of fatigue scores. A ROC curve revealed that IL-6 concentrations of 1.18pg/ml represented the best cut-off value for detecting fatigue (sensitivity of 0.941 and specificity of 0.704). Fatigued PD patients have poor clinical outcomes and elevated IL-6 serum levels when compared with non-fatigued patients. These results suggest that IL-6 may play a role in the pathophysiology of fatigue in PD.
authors: Laboratório de Neurobiologia, Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.
authors: Jéssica Ramos
authors: JR
authors: Pereira
authors: Laboratório de Neurobiologia, Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.
authors: Lílian Viana Dos
authors: LVD
authors: Santos
authors: Laboratório de Neurobiologia, Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.
authors: Renata Maria Silva
authors: RMS
authors: Santos
authors: Laboratório de Neurobiologia, Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.
authors: Ana Luíza Figueiredo
authors: ALF
authors: Campos
authors: Laboratório de Neurobiologia, Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.
authors: André Lana
authors: AL
authors: Pimenta
authors: Laboratório de Neurobiologia, Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.
authors: Mateus Silva
authors: MS
authors: de Oliveira
authors: Laboratório de Neurobiologia, Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.
authors: Geander Gaburro
authors: GG
authors: Bacheti
authors: Laboratório Interdisciplinar de Investigação Médica, Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.
authors: Natália Pessoa
authors: NP
authors: Rocha
authors: Laboratório Interdisciplinar de Investigação Médica, Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.
authors: Antônio Lúcio
authors: AL
authors: Teixeira
authors: Ambulatório de Neurologia, Centro de Especialidades Médicas da Santa Casa de Belo Horizonte, Belo Horizonte, MG, Brazil.
authors: Paulo Pereira
authors: PP
authors: Christo
authors: Laboratório de Neurobiologia, Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil. Electronic address: paula@icb.ufmg.br.
authors: Paula Luciana
authors: PL
authors: Scalzo
mesh_terms: D000368:Aged; D000978:Antiparkinson Agents / Q000627:therapeutic use; D015415:Biomarkers / Q000097:blood; D005221:Fatigue / Q000097:blood* / Q000150:complications*; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D016015:Logistic Models; D008297:Male; D008609:Mental Status Schedule; D008875:Middle Aged; D010300:Parkinson Disease / Q000097:blood* / Q000150:complications* / Q000188:drug therapy; D012372:ROC Curve; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D000978:Antiparkinson Agents; D015415:Biomarkers; C508600:IL6 protein, human; D015850:Interleukin-6
keywords: Fatigue; Inflammation; Interleukin-6; Parkinson's disease