title: Current status and future prospects for enabling chemistry technology in the drug discovery process.
abstract: This review covers recent advances in the implementation of enabling chemistry technologies into the drug discovery process. Areas covered include parallel synthesis chemistry, high-throughput experimentation, automated synthesis and purification methods, flow chemistry methodology including photochemistry, electrochemistry, and the handling of "dangerous" reagents. Also featured are advances in the "computer-assisted drug design" area and the expanding application of novel mass spectrometry-based techniques to a wide range of drug discovery activities.
authors: Discovery Chemistry and Technology, AbbVie, North Chicago, IL, USA.
authors: Stevan W
authors: SW
authors: Djuric
authors: Discovery Chemistry and Technology, AbbVie, North Chicago, IL, USA.
authors: Charles W
authors: CW
authors: Hutchins
authors: Discovery Chemistry and Technology, AbbVie, North Chicago, IL, USA.
authors: Nari N
authors: NN
authors: Talaty
keywords: Chemistry technologies; computer-assisted drug design; drug discovery; electrochemistry; parallel synthesis chemistry; photochemistry