title: Meta-analysis reveals no significant association between ERCC6 polymorphisms and bladder cancer risk.
abstract: BACKGROUND
  Numerous studies have been conducted to evaluate the association between excision repair cross-complementing group 6 (ERCC6) gene polymorphisms and bladder cancer risk, but their findings have been inconsistent. Here we performed a meta-analysis to attempt to clarify this association.
  
  
  METHODS
  Studies were retrieved from the PubMed and China National Knowledge Infrastructure databases up to October 1, 2015, with strict selection and exclusion criteria. A total of 5,032 samples, comprising samples from 2,475 bladder cancer patients and 2,557 controls from 5 studies, were included in the meta-analysis. The odds ratio (OR) with 95% confidence interval (CI) was used to evaluate the strength of the associations.
  
  
  RESULTS
  Regarding the Met1097Val polymorphism, no significant association with bladder cancer risk was found in any of the genetic models evaluated (Val vs. Met: OR = 1.10, 95% CI, 0.97-1.25; Val/Val vs. Met/Met: OR = 1.23, 95% CI, 0.86-1.75; Val/Val + Val/Met vs. Met/Met: OR = 1.12, 95% CI, 0.96-1.30; Val/Val vs. Met/Met + Val/Met: OR = 0.81, 95% CI, 0.57-1.14). Similarly, as regards the Arg1230Pro polymorphism, we also found no positive results.
  
  
  CONCLUSIONS
  According to the results of our meta-analysis, there is no evidence of a link between the ERCC6 gene polymorphisms and bladder cancer risk. Well-designed further studies, with larger sample sizes and adjustment for confounders such as smoking status, are needed to confirm these conclusions.
authors:  Department of Urology Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang - PR China.
authors: Zhengdong
authors: Z
authors: Hong
authors:  Department of Nursing Care, The Third People's Hospital of Shangrao, Shangrao - PR China.
authors: Jinxian
authors: J
authors: Wu
authors:  Department of General Surgery, The First People's Hospital of Fuzhou, Fuzhou - PR China.
authors: Qiang
authors: Q
authors: Li
authors:  Department of Urology Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang - PR China.
authors: Shouhua
authors: S
authors: Zhang
authors:  Department of Urology Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang - PR China.
authors: Zimin
authors: Z
authors: Shi
mesh_terms: D016022:Case-Control Studies; D004265:DNA Helicases / Q000235:genetics*; D045643:DNA Repair Enzymes / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D000075223:Poly-ADP-Ribose Binding Proteins; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011379:Prognosis; D012307:Risk Factors; D001749:Urinary Bladder Neoplasms / Q000235:genetics*
chemical_list: D000075223:Poly-ADP-Ribose Binding Proteins; D004265:DNA Helicases; C078673:ERCC6 protein, human; D045643:DNA Repair Enzymes