title: The utility of lupus serology in predicting outcomes of renal transplantation in lupus patients: Systematic literature review and analysis of the Toronto lupus cohort.
abstract: To study the utility of lupus serology as a predictor for kidney graft outcome in (a) a systematic literature review (SLR) and (b) the Toronto lupus cohort (TLC).
  
  
  
  For the SLR, a comprehensive literature search was performed to identify the articles reporting on the serology at renal transplantation (RT) and on the outcome of RT. Studies were critically appraised using the Newcastle Ottawa Scale (NOS). Patients who underwent RT in the TLC were identified and grouped into graft failure and graft survival. The serology in both groups was studied.
  
  
  
  Of the 749 references, 742 did not have serological status of the patient or were not relevant to the research question. Seven studies in addition to TLC (n = 76) were included in the SLR. The NOS revealed limitations because of small sample size and a short follow-up period. The majority of the grafts survived to at least 1 year regardless of the serology results pre-transplant which is consistent with results of the TLC. Overall, 32 of 1783 patients in the TLC had a RT. In all, 2 patients had a nonfunctional graft, 5 patients had graft failure, and 25 patients had graft survival. Overall, 40% of the graft failures had positive serology compared to 52% in the graft survival, 1 year prior to RT.
  
  
  
  The results of this SLR found that the persistence of serological abnormalities at the time of RT was not associated with graft failure. These results are consistent with the results of the TLC.
authors: Department of Medicine, University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, EW, 1-412, 399 Bathurst St, Toronto, Ontario, Canada M5T 2S8.
authors: Kristy S
authors: KS
authors: Yap
authors: Department of Medicine, University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, EW, 1-412, 399 Bathurst St, Toronto, Ontario, Canada M5T 2S8; Department of Medicine, University of Toronto, Toronto Western Research Institute, Toronto, Ontario, Canada.
authors: Murray B
authors: MB
authors: Urowitz
authors: The Institute for Work and Health, Toronto, Ontario, Canada.
authors: Quenby
authors: Q
authors: Mahood
authors: Department of Medicine, University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, EW, 1-412, 399 Bathurst St, Toronto, Ontario, Canada M5T 2S8.
authors: Jorge
authors: J
authors: Medina-Rosas
authors: Department of Medicine, University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, EW, 1-412, 399 Bathurst St, Toronto, Ontario, Canada M5T 2S8.
authors: Arthy
authors: A
authors: Sabapathy
authors: Department of Medicine, University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, EW, 1-412, 399 Bathurst St, Toronto, Ontario, Canada M5T 2S8.
authors: Daeria
authors: D
authors: Lawson
authors: Department of Medicine, University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, EW, 1-412, 399 Bathurst St, Toronto, Ontario, Canada M5T 2S8.
authors: Jiandong
authors: J
authors: Su
authors: Department of Medicine, University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, EW, 1-412, 399 Bathurst St, Toronto, Ontario, Canada M5T 2S8; Department of Medicine, University of Toronto, Toronto Western Research Institute, Toronto, Ontario, Canada.
authors: Dafna D
authors: DD
authors: Gladman
authors: Department of Medicine, University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, EW, 1-412, 399 Bathurst St, Toronto, Ontario, Canada M5T 2S8; The Institute for Work and Health, Toronto, Ontario, Canada. Electronic address: zahi.touma@uhn.ca.
authors: Zahi
authors: Z
authors: Touma
mesh_terms: D000328:Adult; D016208:Databases, Factual; D005260:Female; D006085:Graft Survival; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000209:etiology / Q000601:surgery*; D016030:Kidney Transplantation; D008181:Lupus Nephritis / Q000097:blood / Q000150:complications / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016896:Treatment Outcome
keywords: Lupus nephritis; Outcomes; Renal transplantation; SLE; Serology