title: Terpenoids from Melampodium perfoliatum.
abstract: The phytochemical study of the aerial parts of Melampodium perfoliatum afforded six melampolides (1, 3, 5-8), a eudesmanolide (9), two diterpene lactones (10, 11), and two ent-kaurane derivatives (12, 13), together with the known melampodin (2) and polymatin A (4). The structures of the compounds were elucidated by physical data analysis and chemical reactions. Compounds 2, 4, 5, and 10 exhibited dose-dependent anti-inflammatory activity on the 12-O-tetradecanoylphorbol-13-acetate-induced ear edema model, with ID50values of 1.14, 0.56, 1.15, and 1.49 μmol/ear, respectively, compared to the reference compound indomethacin (0.24 μmol/ear).
authors: Instituto de Química and ‡Instituto de Biología, Universidad Nacional Autónoma de México, Universidad Nacional Autónoma de México , Circuito Exterior, Ciudad Universitaria, Coyoacán 04510, Ciudad de México, México.
authors: Amira
authors: A
authors: Arciniegas
authors: Instituto de Química and ‡Instituto de Biología, Universidad Nacional Autónoma de México, Universidad Nacional Autónoma de México , Circuito Exterior, Ciudad Universitaria, Coyoacán 04510, Ciudad de México, México.
authors: Ana-L
authors: AL
authors: Pérez-Castorena
authors: Instituto de Química and ‡Instituto de Biología, Universidad Nacional Autónoma de México, Universidad Nacional Autónoma de México , Circuito Exterior, Ciudad Universitaria, Coyoacán 04510, Ciudad de México, México.
authors: Antonio
authors: A
authors: Nieto-Camacho
authors: Instituto de Química and ‡Instituto de Biología, Universidad Nacional Autónoma de México, Universidad Nacional Autónoma de México , Circuito Exterior, Ciudad Universitaria, Coyoacán 04510, Ciudad de México, México.
authors: José L
authors: JL
authors: Villaseñor
authors: Instituto de Química and ‡Instituto de Biología, Universidad Nacional Autónoma de México, Universidad Nacional Autónoma de México , Circuito Exterior, Ciudad Universitaria, Coyoacán 04510, Ciudad de México, México.
authors: Alfonso
authors: A
authors: Romo de Vivar
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D019659:Asteraceae / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000139:chemically induced; D007213:Indomethacin / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D008800:Mexico; D051379:Mice; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D035261:Plant Components, Aerial / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
chemical_list: D000893:Anti-Inflammatory Agents; D007783:Lactones; D012717:Sesquiterpenes; D013729:Terpenes; C476916:eudesmanolide; D013755:Tetradecanoylphorbol Acetate; D007213:Indomethacin