title: Case Report of a Patient Undergoing Peritoneal Dialysis with Encapsulating Peritoneal Sclerosis Superimposed With Calciphylaxis.
abstract: BACKGROUND
  Encapsulating peritoneal sclerosis (EPS) is a rare but devastating complication of peritoneal dialysis (PD). Tamoxifen has been generally well-tolerated, even without randomized controlled trials.
  
  
  METHODS
  Herein, we report a case of a patient undergoing 12 years of PD who developed EPS and calciphylaxis simultaneously. We also provide a comprehensive discussion about the association between EPS and calciphylaxis. Moreover, although tamoxifen is used in EPS due to its inhibition of fibroblast-transforming growth factor beta (TGFβ) production, it may worsen the calciphylaxis due to a hypercoagulable state.
  
  
  CONCLUSIONS
  We suggest avoiding the use of tamoxifen for EPS in patients with superimposed calciphylaxis.
authors: Department of Family Medicine, Cheng Ching General Hospital, Taichung, Taiwan.
authors: Jun
authors: J
authors: Li Tsai
authors: Division of Nephrology, Department of Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
authors: Ming
authors: M
authors: Ju Wu
authors: Division of Nephrology, Department of Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
authors: Cheng
authors: C
authors: Hsu Chen
authors: Division of Nephrology, Department of Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; Department of Life Science, Tunghai University, Taichung, Taiwan.
authors: Shang
authors: S
authors: Feng Tsai
keywords: Calciphylaxis; Encapsulating Peritoneal Sclerosis; Tamoxifen