title: Native valve Proteus mirabilis endocarditis: successful treatment of a rare entity formulated by in vitro synergy antibiotic testing.
abstract: Infective endocarditis caused by Proteus mirabilis is a rare and poorly reported disease, with no well-defined effective antibiotic regimen. Here, we present a case of P. mirabilis aortic valve endocarditis. We reviewed prior cases and treatment regimens, and devised effective treatment, which was guided by in vitro sensitivity and synergy testing on the pathogen. Our patient survived without complications or the need for a surgical intervention.
authors: Department of Medicine, University at Buffalo State University of New York, School of Medicine and Biomedical Sciences, Buffalo, New York, USA.
authors: Caroline R
authors: CR
authors: Brotzki
authors: Department of Pharmacy, Veterans Administration Western New York Healthcare System, Buffalo, New York, USA.
authors: Kari A
authors: KA
authors: Mergenhagen
authors: Laboratory for Antimicrobial Pharmacodynamics, University at Buffalo School of Pharmacy and Pharmaceutical Sciences, Buffalo, New York, USA.
authors: Zackery P
authors: ZP
authors: Bulman
authors: Laboratory for Antimicrobial Pharmacodynamics, University at Buffalo School of Pharmacy and Pharmaceutical Sciences, Buffalo, New York, USA.
authors: Brian T
authors: BT
authors: Tsuji
authors: State University of New York at Buffalo, Buffalo, New York, USA.|Veterans Administration Western New York Healthcare System, Buffalo, NY, USA.
authors: Charles S
authors: CS
authors: Berenson
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001021:Aortic Valve / Q000000981:diagnostic imaging; D002443:Ceftriaxone / Q000627:therapeutic use*; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D004452:Echocardiography; D004697:Endocarditis, Bacterial / Q000000981:diagnostic imaging / Q000188:drug therapy*; D005839:Gentamicins / Q000627:therapeutic use*; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D011512:Proteus Infections / Q000000981:diagnostic imaging / Q000188:drug therapy*; D011513:Proteus mirabilis
chemical_list: D000900:Anti-Bacterial Agents; D005839:Gentamicins; D002443:Ceftriaxone