title: Association Between the IL-6 rs1800795 Polymorphism and the Risk of Cervical Cancer: A Meta-Analysis of 1210 Cases and 1525 Controls.
abstract: Cervical cancer is the second most common cancer and the third leading cause of cancer-related death among females in less developed countries. Studies have shown that the single-nucleotide polymorphisms of interleukin 6 might be associated with cervical cancer risk. A total of 710 articles from EMBASE, EBSCO, Web of science, PubMed, Springer link, and Chinese National Knowledge Infrastructure databases were reviewed in our study. A meta-analysis on the associations between interleukin 6 rs1800795 polymorphism and cervical cancer risk was carried out by comparison using 5 genetic models. In this systematic review, 5 studies were analyzed. The pooled population included 2735 participants (1210 cases and 1525 controls). The overall odds ratio (G vs C alleles) using fixed-effects model was 0.85 (95% confidence interval 0.75-0.97), P = .02. Our results show that the C genotype of interleukin 6 rs1800795 is associated with higher cervical cancer risk. Our results indicate that interleukin 6 rs1800795 polymorphism might be associated with susceptibility to cervical cancer.
authors: 1 Jinan Military General Hospital, Tianqiao, Jinan, Shandong, China.
authors: Haiping
authors: H
authors: Liu
authors: 2 Department of Pain, Tianjin First Center Hospital, Nankai, Tianjin, China.
authors: Dan
authors: D
authors: Lyu
authors: 1 Jinan Military General Hospital, Tianqiao, Jinan, Shandong, China.
authors: Yan
authors: Y
authors: Zhang
authors: 1 Jinan Military General Hospital, Tianqiao, Jinan, Shandong, China.
authors: Lianbing
authors: L
authors: Sheng
authors: 1 Jinan Military General Hospital, Tianqiao, Jinan, Shandong, China.
authors: Ning
authors: N
authors: Tang
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics*; D015810:Linkage Disequilibrium; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D002583:Uterine Cervical Neoplasms / Q000235:genetics*
chemical_list: D015850:Interleukin-6
keywords: SNP; cervical cancer; interleukin 6; meta-analysis; polymorphism