title: Epidemiological study of hepatitis B virus among prisoners with active tuberculosis in Central Brazil.
abstract: Due to environmental and social conditions inherent to incarceration, tuberculosis (TB) and hepatitis B virus (HBV) are major diseases among prison inmates.
  
  
  
  To determine overall and occult HBV infection (OBI) prevalence rates, risk factors and genotype distribution among inmates with active TB.
  
  
  
  A cross-sectional study was conducted among 216 inmates with active TB recruited at the largest prisons in Campo Grande, Mato Grosso do Sul, Central Brazil. The participants were interviewed and tested for the presence of serological markers for HBV infection.
  
  
  
  The overall prevalence of HBV infection (total hepatitis B core antibodies) was 10.2% (95%CI 6.2-14.2). HBV surface antigen (HBsAg) prevalence was 1.4% (3/216). HBV DNA was detected in all three HBsAg-positive samples and in 10.5% (2/19) of the anti-HBc-positive samples (OBI), giving a HBV-TB co-infection prevalence of 2.3% (5/216). A multivariate analysis of risk factors showed that history of sharing cutting instruments, length of incarceration and homosexual sex were associated with HBV infection.
  
  
  
  Our findings indicate that HBV remains an important public health concern among prison inmates and active TB-HBV co-infection needs to be addressed for effective treatment.
authors: Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil.
authors: L M M
authors: LM
authors: Iglecias
authors: Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil.
authors: M A M
authors: MA
authors: Puga
authors: Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil.
authors: M A
authors: MA
authors: Pompílio
authors: School of Nursing, Federal University of Goiás, Goiânia, Goiás, Brazil.
authors: S A
authors: SA
authors: Teles
authors: Federal University of Grande Dourados, Dourados, Mato Grosso do Sul , Oswaldo Cruz Foundation, Mato Grosso do Sul, Mato Grosso do Sul, Brazil.
authors: J
authors: J
authors: Croda
authors: Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil.
authors: L A
authors: LA
authors: Lima
authors: Laboratory of Molecular Virology, Instituto Oswaldo Cruz/Fundação Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro, Brazil.
authors: B V
authors: BV
authors: Lago
authors: Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiânia, Goiás, Brazil.
authors: R M B
authors: RM
authors: Martins
authors: Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Oswaldo Cruz Foundation, Mato Grosso do Sul, Mato Grosso do Sul, Brazil.
authors: A R C
authors: AR
authors: Motta-Castro
mesh_terms: D000328:Adult; D001938:Brazil / Q000453:epidemiology; D060085:Coinfection / Q000175:diagnosis / Q000453:epidemiology*; D003430:Cross-Sectional Studies; D004279:DNA, Viral / Q000302:isolation & purification; D016021:Epidemiologic Studies; D005260:Female; D006509:Hepatitis B / Q000175:diagnosis / Q000453:epidemiology*; D006510:Hepatitis B Antibodies / Q000097:blood; D006514:Hepatitis B Surface Antigens / Q000097:blood; D006515:Hepatitis B virus / Q000302:isolation & purification; D006801:Humans; D008297:Male; D015995:Prevalence; D011329:Prisoners; D012307:Risk Factors; D012959:Socioeconomic Factors; D014376:Tuberculosis / Q000453:epidemiology* / Q000821:virology
chemical_list: D004279:DNA, Viral; D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens