title: The feasibility of11C-PIB-PET/CT for amyloid plaque burden: validation of the effectiveness of CT-based partial volume correction.
abstract: Amyloid positron-emission tomography (PET) imaging with11C-Pittsburgh compound B (PiB) is an effective tool for assessing brain amyloid deposits. PET imaging, however, can suffer from the partial volume effect (PVE). PVE has been corrected using MRI (magnetic resonance imaging) image data. However, correction of the PVE of PET using MRI usually requires two separate procedures, imposing a burden on patients and leading to low throughput and inefficient diagnoses. The advent of PET/computed tomography (PET/CT) may potentially overcome these problems and offer higher throughput and reliable quantification of amyloid plaques and assessment of Alzheimer disease (AD).
  
  
  
  We investigated the feasibility of correcting PVE in amyloid PET using CT, obtained by PET/CT, instead of MRI. We demonstrated the efficacy of partial volume correction (PVC) based on CT by comparing the results of CT-based PVC and those of MRI-based PVC using images acquired from AD patients and controls.
  
  
  
  Both methods were able to perform PVC. Slight but significant differences between standard uptake volume ratio (SUVR) values were noted between the two modalities; these were attenuated by constant multiplication.
  
  
  
  CT will potentially replace MRI for PVC, allowing the use of a single PET/CT scanner for amyloid plaque quantitation.
authors: Graduate School of Science and Engineering Yamagata University Yamagata Japan; Integrative Brain Imaging Center National Center of Neurology and Psychiatry Kodaira Tokyo Japan; Department of Nuclear Medicine Saitama Medical University International Medical Center Saitama Japan.
authors: Kei
authors: K
authors: Sasaki
authors: Integrative Brain Imaging Center National Center of Neurology and Psychiatry Kodaira Tokyo Japan.
authors: Norihide
authors: N
authors: Maikusa
authors: Integrative Brain Imaging Center National Center of Neurology and Psychiatry Kodaira Tokyo Japan.
authors: Etsuko
authors: E
authors: Imabayashi
authors: Graduate School of Science and Engineering Yamagata University Yamagata Japan.
authors: Tetsuya
authors: T
authors: Yuasa
authors: Integrative Brain Imaging Center National Center of Neurology and Psychiatry Kodaira Tokyo Japan; Department of Nuclear Medicine Saitama Medical University International Medical Center Saitama Japan.
authors: Hiroshi
authors: H
authors: Matsuda
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000000981:diagnostic imaging; D000814:Aniline Compounds; D052160:Benzothiazoles; D001921:Brain / Q000000981:diagnostic imaging*; D001931:Brain Mapping / Q000379:methods; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D058225:Plaque, Amyloid / Q000000981:diagnostic imaging*; D000072078:Positron Emission Tomography Computed Tomography / Q000379:methods*; D019275:Radiopharmaceuticals; D013844:Thiazoles
chemical_list: C475519:2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole; D000814:Aniline Compounds; D052160:Benzothiazoles; D019275:Radiopharmaceuticals; D013844:Thiazoles
keywords: Alzheimer disease; amyloid plaques/RI; magnetic resonance imaging; multidetector computed tomography; positron‐emission tomography/MT