title: Drug Hypersensitivity Syndrome with Prolonged Course Complicated by Parvovirus Infection.
abstract: Drug hypersensitivity syndrome (DHS) is a severe medication reaction involving multiple organ systems that is characterized by rash, lymphadenopathy, and laboratory aberrations, including hepatic enzyme changes. Viral reactivation in the setting of DHS can significantly affect the course of disease. We report two children in whom parvovirus infection prolonged and complicated their course of DHS. Most other DHS-complicating viruses are herpesviruses; this report broadens the scope of DHS-modifying infections to include activation of Parvoviridae.
authors: Division of Dermatology, Departments of Medicine and Pediatrics, Washington University School of Medicine, St. Louis, Missouri.
authors: Carrie C
authors: CC
authors: Coughlin
authors: Section of Pediatric Dermatology, Division of General Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.|Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.|Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
authors: Melinda V
authors: MV
authors: Jen
authors: Division of Dermatology, Department of Pediatrics, Seattle Children's Hospital, Seattle, Washington.
authors: Markus D
authors: MD
authors: Boos
mesh_terms: D000293:Adolescent; D002648:Child; D063926:Drug Hypersensitivity Syndrome / Q000150:complications* / Q000201:enzymology; D006801:Humans; D008297:Male; D010322:Parvoviridae Infections / Q000209:etiology*; D000637:Transaminases / Q000097:blood; D014775:Virus Activation
chemical_list: D000637:Transaminases