title: Genetic polymorphisms in leptin, adiponectin and their receptors affect risk and aggressiveness of prostate cancer: evidence from a meta-analysis and pooled-review.
abstract: Leptin and adiponectin signaling was associated with development and progression of various cancers. The present study aimed to clarify the role of genetic variants in leptin, adiponectin and their receptors in prostate cancer. After comprehensive search and manuscript scanning, a total of 49 genetic variants were enrolled and examined for their relations to cancer risk and aggressiveness. In the meta-analysis, LEP rs7799039 (allele contrast: OR 1.133, 95%CI 1.024-1.254), ADIPOQ rs2241766 (allele contrast: OR 1.201, 95%CI 1.015-1.422) and ADIPOR1 rs10920531 (allele contrast: OR 1.184, 95%CI 1.075-1.305) variants were identified to be correlated with increased risk of prostate cancer. On the contrary, LEPR rs1137101 (allele contrast: OR 0.843, 95%CI 0.730-0.973) and ADIPOR1 rs2232853 (allele contrast: OR 0.638, 95%CI 0.535-0.760) variants were associated with decreased risk of prostate cancer. From the pooled-review, we additionally recognized eight variants associated with cancer risk and another eight variants associated with cancer aggressiveness, respectively. These observations indicated important roles of leptin, adiponectin and their receptors in the development and progression of prostate cancer. The identified polymorphisms might assist in developing better risk-assessment tools, as well as generating novel targeted therapies, especially for obese cancer patients with impaired leptin and adiponectin signaling.
authors: Department of Urology, Huashan Hospital, Fudan University, Shanghai 200040, China.
authors: Meng-Bo
authors: MB
authors: Hu
authors: Department of Urology, Huashan Hospital, Fudan University, Shanghai 200040, China.
authors: Hua
authors: H
authors: Xu
authors: Department of Urology, Huashan Hospital, Fudan University, Shanghai 200040, China.
authors: Ji-Meng
authors: JM
authors: Hu
authors: Department of Urology, Huashan Hospital, Fudan University, Shanghai 200040, China.
authors: Wen-Hui
authors: WH
authors: Zhu
authors: Department of Urology, Huashan Hospital, Fudan University, Shanghai 200040, China.
authors: Tian
authors: T
authors: Yang
authors: Department of Urology, Huashan Hospital, Fudan University, Shanghai 200040, China.
authors: Hao-Wen
authors: HW
authors: Jiang
authors: Department of Urology, Huashan Hospital, Fudan University, Shanghai 200040, China.
authors: Qiang
authors: Q
authors: Ding
mesh_terms: D052242:Adiponectin / Q000235:genetics* / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000235:genetics* / Q000378:metabolism; D018450:Disease Progression; D018572:Disease-Free Survival; D020022:Genetic Predisposition to Disease; D006801:Humans; D020738:Leptin / Q000235:genetics* / Q000378:metabolism; D008297:Male; D060787:Neoplasm Grading; D016017:Odds Ratio; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000401:mortality / Q000473:pathology / Q000628:therapy; D054419:Receptors, Adiponectin / Q000235:genetics* / Q000378:metabolism; D054411:Receptors, Leptin / Q000235:genetics* / Q000378:metabolism; D018570:Risk Assessment; D012307:Risk Factors; D015398:Signal Transduction; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: C499918:ADIPOQ protein, human; C475418:ADIPOR1 protein, human; D052242:Adiponectin; D014408:Biomarkers, Tumor; C515448:LEPR protein, human; D020738:Leptin; D054419:Receptors, Adiponectin; D054411:Receptors, Leptin
keywords: adiponectin; genetic polymorphism; leptin; meta-analysis; prostate cancer