title: Telocyte Behaviour During Inflammation, Repair and Tumour Stroma Formation.
abstract: In this chapter, we outline the role of human CD34+ stromal cells/telocytes (CD34+ SC/TCs) as progenitor cells during repair. The in vivo activation phenomena of CD34+ SC/TCs in this process include increased size; separation from the neighbouring structures (mainly of the vascular walls); association with inflammatory cells, predominantly macrophages; development of the organelles of synthesis (rough endoplasmic reticulum and Golgi apparatus); cell proliferation with presence of mitosis and high proliferative index (transit-amplifying cells); and fibroblastic and myofibroblastic differentiation. A procedure to study these tissue-resident cells, comparison of their behaviour in vivo and in vitro and different behaviour depending on location, time, type of injury (including tumour stroma) and greater or lesser proximity to the injury are also considered.
authors: Department of Anatomy, Pathology, Histology and Radiology, Faculty of Medicine, University of La Laguna, Tenerife, Spain. kayto54@gmail.com.
authors: L
authors: L
authors: Díaz-Flores
authors: Department of Anatomy, Pathology, Histology and Radiology, Faculty of Medicine, University of La Laguna, Tenerife, Spain.
authors: R
authors: R
authors: Gutiérrez
authors: Department of Anatomy, Pathology, Histology and Radiology, Faculty of Medicine, University of La Laguna, Tenerife, Spain.
authors: M
authors: M
authors: González-Gómez
authors: Department of Anatomy, Pathology, Histology and Radiology, Faculty of Medicine, University of La Laguna, Tenerife, Spain.
authors: L
authors: L
authors: Díaz-Flores
authors: Department of Anatomy, Pathology, Histology and Radiology, Faculty of Medicine, University of La Laguna, Tenerife, Spain.
authors: F
authors: F
authors: Valladares
authors: Department of Anatomy, Pathology, Histology and Radiology, Faculty of Medicine, University of La Laguna, Tenerife, Spain.
authors: N
authors: N
authors: Rancel
authors: Department of Cell Biology and Histology, UFI11/44, School of Medicine and Dentistry, University of the Basque Country, UPV/EHU, Leioa, Spain.
authors: F J
authors: FJ
authors: Sáez
authors: Department of Cell Biology and Histology, School of Medicine, Regional Campus of International Excellence, "Campus Mare Nostrum" University of Murcia, Murcia, Spain.
authors: J F
authors: JF
authors: Madrid
mesh_terms: D000818:Animals; D018952:Antigens, CD34 / Q000235:genetics / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism; D000072645:Cancer-Associated Fibroblasts / Q000378:metabolism / Q000473:pathology*; D002454:Cell Differentiation; D049109:Cell Proliferation; D015870:Gene Expression; D006801:Humans; D007249:Inflammation; D008264:Macrophages / Q000378:metabolism / Q000473:pathology*; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D013234:Stem Cells / Q000166:cytology* / Q000378:metabolism; D000067170:Telocytes / Q000166:cytology* / Q000378:metabolism; D014945:Wound Healing; D014950:Wounds, Penetrating / Q000235:genetics / Q000378:metabolism / Q000473:pathology*
chemical_list: D018952:Antigens, CD34; D015415:Biomarkers