title: Inherited Chromosomally Integrated Human Herpesvirus 6 and Breast Cancer.
abstract: Background:Inherited chromosomally integrated human herpesvirus 6 (iciHHV-6) is a condition observed in approximately 1% of the population. Whether such a genetic alteration predisposes to cancer development in currently unknown. Two studies were conducted to determine whether iciHHV-6 is associated with cancer development.Methods:First, a screen of 19,597 people from the province of Quebec (Canada) was conducted. A replication test, using data from a population-based case-control study of 1,090 women with incident breast cancer and 1,053 controls from British Columbia and Ontario (Canada) was conducted. DNA samples were analyzed by qPCR and droplet digital PCR to identify iciHHV-6+carriers.Results:In the initial study, a potential association between iciHHV-6 positivity and breast cancer was identified [OR = 2.66; 95% confidence interval (CI), 0.95-7.44]. In the replication dataset, no association was found between iciHHV-6 positivity in women and breast cancer (OR = 0.87; 95% CI, 0.35-2.15).Conclusions:We found no statistically significant associations between inherited chromosomally integrated HHV-6 and breast cancer in women.Impact:These results do not provide evidence to suggest that iciHHV-6 is a risk factor for breast cancer.Cancer Epidemiol Biomarkers Prev; 26(3); 425-7. ©2016 AACR.
authors: Division of Infectious Disease and Immunity, CHU de Québec Research Center and Department of Microbiology-Infectious Disease, Quebec, Canada.
authors: Annie
authors: A
authors: Gravel
authors: Division of Infectious Disease and Immunity, CHU de Québec Research Center and Department of Microbiology-Infectious Disease, Quebec, Canada.
authors: Isabelle
authors: I
authors: Dubuc
authors: Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, British Columbia, Canada.|Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, British Columbia, Canada.
authors: Angela
authors: A
authors: Brooks-Wilson
authors: Department of Public Health Sciences, and Queen's Cancer Institute, Queen's University, Kingston, Ontario, Canada.
authors: Kristan J
authors: KJ
authors: Aronson
authors: Department of Molecular Medicine, Faculty of Medicine, Université Laval, Quebec, Canada.
authors: Jacques
authors: J
authors: Simard
authors: School of Population & Public Health, University of British Columbia, Vancouver, British Columbia, Canada.
authors: Héctor A
authors: HA
authors: Velásquez-García
authors: School of Population & Public Health, University of British Columbia, Vancouver, British Columbia, Canada.|Cancer Control Research, BC Cancer Agency, Vancouver, British Columbia, Canada.
authors: John J
authors: JJ
authors: Spinelli
authors: Division of Infectious Disease and Immunity, CHU de Québec Research Center and Department of Microbiology-Infectious Disease, Quebec, Canada. louis.flamand@crchul.ulaval.ca.|Department of Microbiology, Infectious Disease and Immunology, Faculty of Medicine, Université Laval, Quebec, Canada.
authors: Louis
authors: L
authors: Flamand
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000453:epidemiology / Q000235:genetics*; D001955:British Columbia; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D016679:Genome, Viral; D055106:Genome-Wide Association Study; D015654:Herpesvirus 6, Human / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009864:Ontario; D011159:Population Surveillance; D015995:Prevalence; D011792:Quebec; D012307:Risk Factors; D016662:Virus Integration / Q000235:genetics*