title: Alcohol consumption and prevalence of erectile dysfunction in Japanese patients with type 2 diabetes mellitus: Baseline data from the Dogo Study.
abstract: Diabetes mellitus and heavy alcohol consumption are both associated with vascular disease, a category that includes erectile dysfunction (ED). However, the association between alcohol consumption and ED among patients with type 2 diabetes mellitus remains unclear. The aim of the present multicenter cross-sectional study was to investigate the relationship between drinking frequency, weekly alcohol consumption, daily alcohol consumption, and ED among Japanese patients with type 2 diabetes mellitus. Study subjects were 340 male Japanese patients with type 2 diabetes mellitus, aged 19-70 years, who had undergone blood tests at our institutions. A self-administered questionnaire was used to collect information on the variables under study. ED was defined as present when a subject had a Sexual Health Inventory for Men score <8. Adjustment was made for age, body mass index, duration of type 2 diabetes mellitus, current smoking, hypertension, dyslipidemia, glycated hemoglobin, stroke, coronary artery disease, diabetic retinopathy, diabetic nephropathy, and diabetic neuropathy. The prevalence of ED was 43.2% (147/340). The frequency of alcohol consumption and weekly alcohol consumption were independently inversely associated with ED (p for trend p = 0.001 and 0.004, respectively). The relationship between daily alcohol consumption and ED was an inverted J-shaped curve: alcohol consumption of less than 60 g, but not 60 g or more, per day was independently related to a lower prevalence of ED (p for quadratic trend = 0.003). In Japanese men with type 2 diabetes mellitus, an inverted J-shaped relationship between daily alcohol consumption and ED was observed, while frequency of alcohol consumption and weekly alcohol consumption were significantly inversely associated with ED.
authors: Department of Epidemiology and Preventive Medicine, Ehime University Graduate School of Medicine, Ehime, Japan; Epidemiology and Medical Statistics Units, Ehime University Hospital, Ehime, Japan. Electronic address: shinya.furukawa@gmail.com.
authors: Shinya
authors: S
authors: Furukawa
authors: Department of Internal Medicine, Yawatahama General City Hospital, Ehime, Japan.
authors: Takenori
authors: T
authors: Sakai
authors: Department of Internal Medicine, Matsuyama Shimin Hospital, Ehime, Japan.
authors: Tetsuji
authors: T
authors: Niiya
authors: Department of Internal Medicine, Saiseikai Matsuyama Hospital, Ehime, Japan.
authors: Hiroaki
authors: H
authors: Miyaoka
authors: Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Ehime, Japan.
authors: Teruki
authors: T
authors: Miyake
authors: Department of Lifestyle-related Medicine and Endocrinology, Ehime University Graduate School of Medicine, Ehime, Japan.
authors: Shin
authors: S
authors: Yamamoto
authors: Department of Public Health, Juntendo University School of Medicine, Tokyo, Japan.
authors: Koutatsu
authors: K
authors: Maruyama
authors: Department of Internal Medicine, Ehime Prefectural Central Hospital, Ehime, Japan.
authors: Teruhisa
authors: T
authors: Ueda
authors: Department of Epidemiology and Preventive Medicine, Ehime University Graduate School of Medicine, Ehime, Japan; Epidemiology and Medical Statistics Units, Ehime University Hospital, Ehime, Japan.
authors: Keiko
authors: K
authors: Tanaka
authors: Department of Epidemiology and Preventive Medicine, Ehime University Graduate School of Medicine, Ehime, Japan; Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Ehime, Japan.
authors: Hidenori
authors: H
authors: Senba
authors: Department of Internal Medicine, Matsuyama Shimin Hospital, Ehime, Japan.
authors: Yasuhiko
authors: Y
authors: Todo
authors: Department of Internal Medicine, Saiseikai Saijo Hospital, Ehime, Japan.
authors: Masamoto
authors: M
authors: Torisu
authors: Department of Internal Medicine, Ehime Niihama Hospital, Ehime, Japan.
authors: Hisaka
authors: H
authors: Minami
authors: Department of Internal Medicine, Saiseikai Imabari Hospital, Ehime, Japan.
authors: Morikazu
authors: M
authors: Onji
authors: Department of Public Health, Juntendo University School of Medicine, Tokyo, Japan.
authors: Takeshi
authors: T
authors: Tanigawa
authors: Department of Lifestyle-related Medicine and Endocrinology, Ehime University Graduate School of Medicine, Ehime, Japan.
authors: Bunzo
authors: B
authors: Matsuura
authors: Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Ehime, Japan.
authors: Yoichi
authors: Y
authors: Hiasa
authors: Department of Epidemiology and Preventive Medicine, Ehime University Graduate School of Medicine, Ehime, Japan; Epidemiology and Medical Statistics Units, Ehime University Hospital, Ehime, Japan.
authors: Yoshihiro
authors: Y
authors: Miyake
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000428:Alcohol Drinking / Q000453:epidemiology* / Q000639:trends; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D016208:Databases, Factual / Q000639:trends; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis / Q000453:epidemiology*; D007172:Erectile Dysfunction / Q000175:diagnosis / Q000453:epidemiology*; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011446:Prospective Studies; D011795:Surveys and Questionnaires; D055815:Young Adult
keywords: Daily; Diabetes; Drinking; Erectile dysfunction; Weekly