title: Enantioselective Formal C-H Conjugate Addition of Acetanilides to β-Substituted Acrylates by Chiral Iridium Catalysts.
abstract: The Ir-catalyzed enantioselective reaction of substituted acetanilides with β-substituted α,β-unsaturated esters provided chiral 3,3-disubstituted propanoates in high yield with good-to-excellent enantiomeric excess (up to 99 % ee). This transformation, initiated by sp2C-H bond activation, is the first example of enantioselective formal C-H conjugate addition to β-substituted α,β-unsaturated carbonyl compounds. The starting materials are commercially available and/or readily accessible.
authors: Department of Chemistry and Biochemistry, School of Advanced Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku, Tokyo, 169-8555, Japan.|JST, ACT-C, 4-1-8 Honcho, Kawaguchi, Saitama, 332-0012, Japan.
authors: Takanori
authors: T
authors: Shibata
authors: Department of Chemistry and Biochemistry, School of Advanced Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku, Tokyo, 169-8555, Japan.
authors: Masamichi
authors: M
authors: Michino
authors: Department of Chemistry and Biochemistry, School of Advanced Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku, Tokyo, 169-8555, Japan.
authors: Hisaki
authors: H
authors: Kurita
authors: Department of Chemistry and Biochemistry, School of Advanced Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku, Tokyo, 169-8555, Japan.
authors: Yu-Ki
authors: YK
authors: Tahara
authors: International Center for Science and Engineering Programs (ICSEP), Waseda University, 3-4-1 Okubo, Shinjuku, Tokyo, 169-8555, Japan.
authors: Kyalo Stephen
authors: KS
authors: Kanyiva
keywords: C−H alkylation; acetanilides; conjugate addition; enantioselective; iridium