title: Bipolar Disorder and Frontotemporal Dementia: An Intriguing Association.
abstract: Bipolar disorder (BD) could represent a prodromal state of frontotemporal dementia (FTD). Two patients affected by lifelong BD with a progressive decline of cognitive functions, behavioral, and neurological signs, reached the early diagnosis of FTD before the age of 60. They were diagnosed as affected by primary progressive aphasia and FTD with parkinsonism, respectively. A diagnosis of FTD should therefore be taken into account, in case of unexpected cognitive and behavioral decline in patients with a long history of BD. Follow-up studies with genetic, neuropsychological, and neuroimaging markers of these BD/FTD patients could further explore some of the underlying association, opening new viable therapeutic options.
authors: Department of Basic Medical Science, Neuroscience and Sense Organs, Psychiatric Unit, University of Bari "Aldo Moro", Bari, Italy.
authors: Apostolos
authors: A
authors: Papazacharias
authors: Department of Basic Medical Science, Neuroscience and Sense Organs, Neurodegenerative Disease Unit, University of Bari "Aldo Moro", Bari, Italy.
authors: Madia
authors: M
authors: Lozupone
authors: Department of Clinical Research in Neurology, University of Bari "Aldo Moro", "Pia Fondazione Cardinale G. Panico", Tricase, Lecce, Italy.
authors: Maria Rosaria
authors: MR
authors: Barulli
authors: Department of Research & Development, Chiesi Farmaceutici, Parma, Italy.
authors: Rosa
authors: R
authors: Capozzo
authors: Department of Research & Development, Chiesi Farmaceutici, Parma, Italy.
authors: Bruno P
authors: BP
authors: Imbimbo
authors: Department of Basic Medical Science, Neuroscience and Sense Organs, Psychiatric Unit, University of Bari "Aldo Moro", Bari, Italy.
authors: Federica
authors: F
authors: Veneziani
authors: U.O.C. Radiology, "Pia Fondazione Cardinale G. Panico", Tricase, Lecce, Italy.
authors: Roberto
authors: R
authors: De Blasi
authors: Department of Basic Medical Science, Neuroscience and Sense Organs, Psychiatric Unit, University of Bari "Aldo Moro", Bari, Italy.
authors: Marcello
authors: M
authors: Nardini
authors: Department of Medical Sciences, Geriatric Unit & Laboratory of Gerontology and Geriatrics, IRCCS "Casa Sollievo della Sofferenza", San Giovanni Rotondo, Foggia, Italy.
authors: Davide
authors: D
authors: Seripa
authors: Department of Basic Medical Science, Neuroscience and Sense Organs, Neurodegenerative Disease Unit, University of Bari "Aldo Moro", Bari, Italy.|Department of Clinical Research in Neurology, University of Bari "Aldo Moro", "Pia Fondazione Cardinale G. Panico", Tricase, Lecce, Italy.|Department of Medical Sciences, Geriatric Unit & Laboratory of Gerontology and Geriatrics, IRCCS "Casa Sollievo della Sofferenza", San Giovanni Rotondo, Foggia, Italy.
authors: Francesco
authors: F
authors: Panza
authors: Department of Basic Medical Science, Neuroscience and Sense Organs, Neurodegenerative Disease Unit, University of Bari "Aldo Moro", Bari, Italy.|Department of Clinical Research in Neurology, University of Bari "Aldo Moro", "Pia Fondazione Cardinale G. Panico", Tricase, Lecce, Italy.
authors: Giancarlo
authors: G
authors: Logroscino
mesh_terms: D001714:Bipolar Disorder / Q000150:complications* / Q000000981:diagnostic imaging; D018450:Disease Progression; D005260:Female; D057180:Frontotemporal Dementia / Q000150:complications* / Q000000981:diagnostic imaging; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008609:Mental Status Schedule; D008875:Middle Aged; D009483:Neuropsychological Tests
keywords: Bipolar disorder; behavioral decline; cognitive impairment; frontotemporal dementia; parkinsonism; primary progressive aphasia