title: Reassortant Eurasian Avian-Like Influenza A(H1N1) Virus from a Severely Ill Child, Hunan Province, China, 2015.
abstract: In 2015, a novel influenza A(H1N1) virus was isolated from a boy in China who had severe pneumonia. The virus was a genetic reassortant of Eurasian avian-like influenza A(H1N1) (EA-H1N1) virus. The hemagglutinin, neuraminidase, and matrix genes of the reassortant virus were highly similar to genes in EA-H1N1 swine influenza viruses, the polybasic 1 and 2, polymerase acidic, and nucleoprotein genes originated from influenza A(H1N1)pdm09 virus, and the nonstructural protein gene derived from classical swine influenza A(H1N1) (CS H1N1) virus. In a mouse model, the reassortant virus, termed influenza A/Hunan/42443/2015(H1N1) virus, showed higher infectivity and virulence than another human EA-H1N1 isolate, influenza A/Jiangsu/1/2011(H1N1) virus. In the respiratory tract of mice, virus replication by influenza A/Hunan/42443/2015(H1N1) virus was substantially higher than that by influenza A/Jiangsu/1/2011(H1N1) virus. Human-to-human transmission of influenza A/Hunan/42443/2015(H1N1) virus has not been detected; however, given the circulation of novel EA-H1N1 viruses in pigs, enhanced surveillance should be instituted among swine and humans.
authors: Wenfei
authors: W
authors: Zhu
authors: Hong
authors: H
authors: Zhang
authors: Xingyu
authors: X
authors: Xiang
authors: Lili
authors: L
authors: Zhong
authors: Lei
authors: L
authors: Yang
authors: Junfeng
authors: J
authors: Guo
authors: Yiran
authors: Y
authors: Xie
authors: Fangcai
authors: F
authors: Li
authors: Zhihong
authors: Z
authors: Deng
authors: Hong
authors: H
authors: Feng
authors: Yiwei
authors: Y
authors: Huang
authors: Shixiong
authors: S
authors: Hu
authors: Xin
authors: X
authors: Xu
authors: Xiaohui
authors: X
authors: Zou
authors: Xiaodan
authors: X
authors: Li
authors: Tian
authors: T
authors: Bai
authors: Yongkun
authors: Y
authors: Chen
authors: Zi
authors: Z
authors: Li
authors: Junhua
authors: J
authors: Li
authors: Yuelong
authors: Y
authors: Shu
mesh_terms: D000818:Animals; D002460:Cell Line; D002681:China / Q000453:epidemiology; D005814:Genes, Viral; D049674:History, 21st Century; D006801:Humans; D007223:Infant; D053118:Influenza A Virus, H1N1 Subtype / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification / Q000472:pathogenicity; D007251:Influenza, Human / Q000175:diagnosis* / Q000453:epidemiology / Q000266:history / Q000821:virology*; D058885:Multilocus Sequence Typing; D010802:Phylogeny; D012367:RNA, Viral; D016865:Reassortant Viruses; D012698:Serologic Tests; D012720:Severity of Illness Index; D014774:Virulence; D014779:Virus Replication
chemical_list: D012367:RNA, Viral
keywords: China; EA-H1N1; Eurasian avian-like virus; clinical features; genetic reassortant; human origin; infectivity; influenza; influenza A(H1N1) virus; influenza virus; novel virus; reassortant virus; respiratory infections; swine influenza virus; virulence; viruses