title: Evaluating a community-based exercise intervention with adults living with HIV: protocol for an interrupted time series study.
abstract: Our aim was to evaluate a community-based exercise (CBE) intervention with the goal of reducing disability and enhancing health for community-dwelling people living with HIV (PLWH).
  
  
  
  We will use a mixed-methods implementation science study design, including a prospective longitudinal interrupted time series study, to evaluate a CBE intervention with PLWH in Toronto, Canada. We will recruit PLWH who consider themselves medically stable and safe to participate in exercise. In the baseline phase (0-8 months), participants will be monitored bimonthly. In the intervention phase (8-14 months), participants will take part in a 24-week CBE intervention that includes aerobic, resistance, balance and flexibility exercise at the YMCA 3 times per week, with weekly supervision by a fitness instructor, and monthly educational sessions. In the follow-up phase (14-22 months), participants will be encouraged to continue to engage in unsupervised exercise 3 times per week. Quantitative assessment: We will assess cardiopulmonary fitness, strength, weight, body composition and flexibility outcomes followed by the administration of self-reported questionnaires to assess disability and contextual factor outcomes (coping, mastery, stigma, social support) bimonthly. We will use time series regression analysis to determine the level and trend of outcomes across each phase in relation to the intervention. Qualitative assessment: We will conduct a series of face-to-face interviews with a subsample of participants and recreation providers at initiation, midpoint and completion of the 24-week CBE intervention. We will explore experiences and anticipated benefits with exercise, perceived impact of CBE for PLWH and the strengths and challenges of implementing a CBE intervention. Interviews will be audio recorded and analysed thematically.
  
  
  
  Protocol approved by the University of Toronto HIV/AIDS Research Ethics Board. Knowledge translation will occur with stakeholders in the form of presentations and publications in open access peer-reviewed journals.
  
  
  
  NCT02794415; Pre-results.
authors: Department of Physical Therapy, University of Toronto, Toronto, Ontario, Canada.|Rehabilitation Sciences Institute (RSI), University of Toronto, Toronto, Ontario, Canada.|Institute of Health Policy, Management and Evaluation (IHPME), University of Toronto, Toronto, Ontario, Canada.
authors: Kelly K
authors: KK
authors: O'Brien
authors: Institute of Health Policy, Management and Evaluation (IHPME), University of Toronto, Toronto, Ontario, Canada.|Centre for Urban Health Solutions, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada.|Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
authors: Ahmed M
authors: AM
authors: Bayoumi
authors: School of Rehabilitation Science, McMaster University, Hamilton, Ontario, Canada.
authors: Patricia
authors: P
authors: Solomon
authors: School of Rehabilitation Science, McMaster University, Hamilton, Ontario, Canada.
authors: Ada
authors: A
authors: Tang
authors: Realize (formally known as the Canadian Working Group on HIV and Rehabilitation (CWGHR)), Toronto, Ontario, Canada.
authors: Kate
authors: K
authors: Murzin
authors: Casey House, Toronto, Ontario, Canada.
authors: Soo
authors: S
authors: Chan Carusone
authors: Toronto Central Grosvenor Street YMCA, Toronto, Ontario, Canada.
authors: Mehdi
authors: M
authors: Zobeiry
authors: Department of Physical Therapy, University of Toronto, Toronto, Ontario, Canada.
authors: Ayesha
authors: A
authors: Nayar
authors: Department of Physical Therapy, University of Toronto, Toronto, Ontario, Canada.|Rehabilitation Sciences Institute (RSI), University of Toronto, Toronto, Ontario, Canada.|Institute of Health Policy, Management and Evaluation (IHPME), University of Toronto, Toronto, Ontario, Canada.|Division of Health Care and Outcomes, Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada.
authors: Aileen M
authors: AM
authors: Davis
mesh_terms: D000223:Adaptation, Psychological; D000293:Adolescent; D000328:Adult; D001823:Body Composition; D001835:Body Weight; D002170:Canada; D003153:Community Health Services; D006233:Persons with Disabilities; D015444:Exercise; D005260:Female; D015658:HIV Infections / Q000150:complications; D006304:Health Status; D006801:Humans; D065186:Interrupted Time Series Analysis; D008297:Male; D010809:Physical Fitness; D011446:Prospective Studies; D011788:Quality of Life; D016059:Range of Motion, Articular; D012107:Research Design; D057566:Self Report; D057545:Social Stigma; D012944:Social Support
keywords: Exercise; REHABILITATION MEDICINE; community-based exercise; physical activity