title: SATB1 promotes tumor metastasis and invasiveness in oral squamous cell carcinoma.
abstract: OBJECTIVE
  Our aim is to evaluate the expression of SATB1 in human oral squamous cell carcinomas (OSCC) and its role in the invasiveness and metastasis of OSCC.
  
  
  METHODS
  A human OSCC tissue microarray was used to evaluate the expression pattern of SATB1. SATB1 mRNA knockdown was performed in human OSCC cell lines SCC25 and Cal27 to assess the function of SATB1 in the invasiveness and metastasis of OSCC.
  
  
  RESULTS
  SATB1 is highly expressed in human OSCC determined by immunohistochemistry, and its nuclear/cytoplasmic ratio of histoscore is significantly correlated with patients' prognosis. Reduced cell motility, invasiveness, expression of epithelial to mesenchymal transition (EMT) markers (N-cadherin and β-catenin), and elevated expression of epithelial markers were observed in SATB1-knockdown cells in in vitro studies. Depletion of SATB1 also restored a cobblestone-like morphology in TGF-β1-treated cells.
  
  
  CONCLUSIONS
  These findings suggest SATB1 may play an important role in OSCC invasiveness and metastasis.
authors: The State Key Laboratory Breeding Base of Basic Science of Stomatology & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, China.
authors: Y-C
authors: YC
authors: Li
authors: The State Key Laboratory Breeding Base of Basic Science of Stomatology & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, China.|Department of Oral and Maxillofacial-Head and Neck Oncology, School and Hospital of Stomatology, Wuhan University, Wuhan, China.
authors: L-L
authors: LL
authors: Bu
authors: The State Key Laboratory Breeding Base of Basic Science of Stomatology & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, China.
authors: L
authors: L
authors: Mao
authors: The State Key Laboratory Breeding Base of Basic Science of Stomatology & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, China.
authors: S-R
authors: SR
authors: Ma
authors: The State Key Laboratory Breeding Base of Basic Science of Stomatology & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, China.
authors: J-F
authors: JF
authors: Liu
authors: The State Key Laboratory Breeding Base of Basic Science of Stomatology & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, China.
authors: G-T
authors: GT
authors: Yu
authors: The State Key Laboratory Breeding Base of Basic Science of Stomatology & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, China.
authors: W-W
authors: WW
authors: Deng
authors: Department of Oral and Maxillofacial-Head and Neck Oncology, School and Hospital of Stomatology, Wuhan University, Wuhan, China.
authors: W-F
authors: WF
authors: Zhang
authors: The State Key Laboratory Breeding Base of Basic Science of Stomatology & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, China.|Department of Oral and Maxillofacial-Head and Neck Oncology, School and Hospital of Stomatology, Wuhan University, Wuhan, China.
authors: Z-J
authors: ZJ
authors: Sun
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000737:chemistry / Q000235:genetics* / Q000556:secondary*; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000235:genetics; D058750:Epithelial-Mesenchymal Transition / Q000187:drug effects / Q000235:genetics; D055785:Gene Knockdown Techniques; D006801:Humans; D008207:Lymphatic Metastasis; D036961:Matrix Attachment Region Binding Proteins / Q000032:analysis / Q000235:genetics*; D009062:Mouth Neoplasms / Q000737:chemistry / Q000235:genetics* / Q000473:pathology*; D009361:Neoplasm Invasiveness / Q000235:genetics; D009367:Neoplasm Staging; D016212:Transforming Growth Factor beta / Q000494:pharmacology
chemical_list: D036961:Matrix Attachment Region Binding Proteins; C076189:SATB1 protein, human; D016212:Transforming Growth Factor beta
keywords: SATB1; epithelial to mesenchymal transition; metastasis; oral squamous cell carcinoma