title: Diuretics in primary hypertension - Reloaded.
abstract: Diuretics have long been cherished as drugs of choice for uncomplicated primary hypertension. Robust mortality and morbidity data is available for diuretics to back this strategy. Off-late the interest for diuretics has waned off perhaps due to availability of more effective drugs but more likely due to perceived lack of tolerance and side-effect profile of high-dose of diuretics required for mortality benefit. Low-dose diuretics particularly thiazide diuretics are safer but lack the mortality benefit shown by high-dose. However, indapamide and low dose chlorthalidone have fewer side-effects but continue to provide mortality benefit.
authors: Cardiology, AIIMS, New Delhi, India. Electronic address: drsundeepmishra@hotmail.com.
authors: Sundeep
authors: S
authors: Mishra
mesh_terms: D001794:Blood Pressure / Q000187:drug effects*; D004232:Diuretics / Q000627:therapeutic use*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D004232:Diuretics
keywords: Cardiovascular outcome; Chlorthalidone; Diuretics; Hydrochlorothiazide; Indapamide; Mortality