title: New Cutaneous Vaccine Adjuvant that STINGs a Little Less.
abstract: Cutaneous vaccination can be a challenge because the development of local skin inflammation is often unavoidable. Thus, it is important to identify and validate new vaccine adjuvants that enhance immunization without the burden of inflammation. Wang et al. now report on a cyclic GMP-AMP adjuvant, the natural stimulator of interferon genes agonist, providing evidence for potent immune responses without inflammation.
authors: Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK.
authors: Stephan M
authors: SM
authors: Caucheteux
authors: Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK. Electronic address: piguetv@cardiff.ac.uk.
authors: Vincent
authors: V
authors: Piguet
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D000279:Administration, Cutaneous; D000818:Animals; D006801:Humans; D007113:Immunity, Innate; D012871:Skin Diseases / Q000276:immunology / Q000517:prevention & control*; D014611:Vaccination / Q000379:methods*; D014612:Vaccines / Q000008:administration & dosage*
chemical_list: D000276:Adjuvants, Immunologic; D014612:Vaccines