title: Synthesis of Chiral Azabicycles from Pyroglutaminols.
abstract: The stereocontrolled synthesis of a range of substituted bicyclic morpholine and piperazine derivatives is reported from substituted pyroglutaminols via an intramolecular SN2 cyclization as the key step. This enantiospecific approach toward chiral bicyclic morpholines and piperazines offers new opportunities to access these challenging ring systems, which are becoming increasingly common motifs in drug discovery.
authors: Medicinal Chemistry, Medicine Design, Pfizer WorldWide R&D , 445 Eastern Point Road, Groton, Connecticut 06340, United States.
authors: Chulho
authors: C
authors: Choi
authors: Medicinal Chemistry, Medicine Design, Pfizer WorldWide R&D , 445 Eastern Point Road, Groton, Connecticut 06340, United States.
authors: Philippe
authors: P
authors: Nuhant
authors: Medicinal Chemistry, Medicine Design, Pfizer WorldWide R&D , 445 Eastern Point Road, Groton, Connecticut 06340, United States.
authors: James J
authors: JJ
authors: Mousseau
authors: Medicinal Chemistry, Medicine Design, Pfizer WorldWide R&D , 445 Eastern Point Road, Groton, Connecticut 06340, United States.
authors: Xiaojing
authors: X
authors: Yang
authors: Medicinal Chemistry, Medicine Design, Pfizer WorldWide R&D , 610 Main Street, Cambridge, Massachusetts 02139, United States.
authors: Brian S
authors: BS
authors: Gerstenberger
authors: Kutztown University of Pennsylvania , 15200 Kutztown Road, Kutztown, Pennsylvania 19530, United States.
authors: Jessica M
authors: JM
authors: Williams
authors: Medicinal Chemistry, Medicine Design, Pfizer WorldWide R&D , 445 Eastern Point Road, Groton, Connecticut 06340, United States.
authors: Stephen W
authors: SW
authors: Wright