title: Synergistic Anticancer Effect of Peptide-Docetaxel Nanoassembly Targeted to Tubulin: Toward Development of Dual Warhead Containing Nanomedicine.
abstract: Microtubule dynamics play a crucial role in cancer cell division. Various drugs are developed to target microtubule. Although a few of them show potential in treatment of cancer, but success rate is limited due to their poor bioavailability and lack of specificity. Thus, development of highly bioavailable and target specific anticancer drug is extremely necessary. To address these key issues, here, a combination of approaches such as development of a dodecapeptide-docetaxel nanoassembly targeted to tubulin and MUC1 (mucin 1, cell surface associated glycoprotein) targeting oligonucleotide aptamer conjugated liposome for delivering peptide-docetaxel nanoassembly into the breast cancer cell have been demonstrated. These studies reveal that the peptide forms nanoassembly and entraps docetaxel drug. Further, the liposomal formulation of peptide-docetaxel exerts synergistic anticancer effect, activates key mitotic check point proteins, and inhibits bipolar spindle formation, metastatic cancer cell migration, and growth of tumor mimicking 3D multicellular spheroid.
authors: Organic and Medicinal Chemistry Division, Council of Scientific and Industrial Research (CSIR)-Indian Institute of Chemical Biology (IICB), 4, Raja S. C. Mullick Road, Jadavpur, Kolkata, 700032, West Bengal, India.|Academy of Scientific and Innovative Research (AcSIR), CSIR-Indian Institute of Chemical Biology Campus, 4, Raja S. C. Mullick Road, Kolkata, 700 032, West Bengal, India.
authors: Saswat
authors: S
authors: Mohapatra
authors: Organic and Medicinal Chemistry Division, Council of Scientific and Industrial Research (CSIR)-Indian Institute of Chemical Biology (IICB), 4, Raja S. C. Mullick Road, Jadavpur, Kolkata, 700032, West Bengal, India.
authors: Abhijit
authors: A
authors: Saha
authors: Organic and Medicinal Chemistry Division, Council of Scientific and Industrial Research (CSIR)-Indian Institute of Chemical Biology (IICB), 4, Raja S. C. Mullick Road, Jadavpur, Kolkata, 700032, West Bengal, India.|Academy of Scientific and Innovative Research (AcSIR), CSIR-Indian Institute of Chemical Biology Campus, 4, Raja S. C. Mullick Road, Kolkata, 700 032, West Bengal, India.
authors: Prasenjit
authors: P
authors: Mondal
authors: Organic and Medicinal Chemistry Division, Council of Scientific and Industrial Research (CSIR)-Indian Institute of Chemical Biology (IICB), 4, Raja S. C. Mullick Road, Jadavpur, Kolkata, 700032, West Bengal, India.
authors: Batakrishna
authors: B
authors: Jana
authors: Organic and Medicinal Chemistry Division, Council of Scientific and Industrial Research (CSIR)-Indian Institute of Chemical Biology (IICB), 4, Raja S. C. Mullick Road, Jadavpur, Kolkata, 700032, West Bengal, India.
authors: Subhajit
authors: S
authors: Ghosh
authors: Organic and Medicinal Chemistry Division, Council of Scientific and Industrial Research (CSIR)-Indian Institute of Chemical Biology (IICB), 4, Raja S. C. Mullick Road, Jadavpur, Kolkata, 700032, West Bengal, India.
authors: Atanu
authors: A
authors: Biswas
authors: Organic and Medicinal Chemistry Division, Council of Scientific and Industrial Research (CSIR)-Indian Institute of Chemical Biology (IICB), 4, Raja S. C. Mullick Road, Jadavpur, Kolkata, 700032, West Bengal, India.|Academy of Scientific and Innovative Research (AcSIR), CSIR-Indian Institute of Chemical Biology Campus, 4, Raja S. C. Mullick Road, Kolkata, 700 032, West Bengal, India.
authors: Surajit
authors: S
authors: Ghosh
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D000077143:Docetaxel; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D061986:MCF-7 Cells; D018396:Mucin-1 / Q000378:metabolism; D050997:Nanomedicine / Q000379:methods; D053758:Nanoparticles / Q000737:chemistry / Q000627:therapeutic use; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D010455:Peptides / Q000737:chemistry / Q000494:pharmacology; D043823:Taxoids / Q000737:chemistry / Q000494:pharmacology; D014404:Tubulin / Q000378:metabolism*
chemical_list: D000970:Antineoplastic Agents; D018396:Mucin-1; D010455:Peptides; D043823:Taxoids; D014404:Tubulin; D000077143:Docetaxel
keywords: MUC1; antimitotic peptides; combination therapy; docetaxel; tubulin