title: Moisturizing effect of serine-loaded solid lipid nanoparticles and polysaccharide-rich extract of root Phragmites communis incorporated in hydrogel bases.
abstract: This study evaluated the moisturizing effect of serine-loaded solid lipid nanoparticles (serine-SLN) and polysaccharide-rich reed (Phragmites communis) root extract (RRE) incorporated in hydrogel bases. The hydrogels with serine-SLN and/or RRE were carefully applied on the volar forearm of human volunteers. Their moisturizing efficacy was evaluated by monitoring conductance values using a skin surface hygrometer. The values of the area under the normalized conductance-time curve (AUCC) were developed and compared as a parameter for the water holding capacity of the skin. Hydrogels with serine-SLN did not significantly moisturize the skin, while hydrogel containing 0.25% RRE produced a significant increase in the moisture content of the skin. However, adding more than 0.25% of RRE into the hydrogel base decreased the moisturizing effect due to the marked reduction of viscosity. Significantly enhanced moisturizing effect was observed with the hydrogel containing 0.25% RRE and 3% serine-SLN, with AUCC increased 2.21 times compared to than blank hydrogel. The results imply that effective delivery of serine into the skin is possible using lipid-based nanocarriers and RRE, which could be a promising strategy to moisturize the skin effectively.
authors: College of Pharmacy, Chung-Ang University, 84 Heuksuk-ro, Dongjak-gu, Seoul, 06974, Republic of Korea.
authors: Sonia
authors: S
authors: Barua
authors: College of Pharmacy, Chung-Ang University, 84 Heuksuk-ro, Dongjak-gu, Seoul, 06974, Republic of Korea.
authors: Hyeongmin
authors: H
authors: Kim
authors: College of Pharmacy, Chung-Ang University, 84 Heuksuk-ro, Dongjak-gu, Seoul, 06974, Republic of Korea.
authors: Seong-Chul
authors: SC
authors: Hong
authors: College of Pharmacy, Chung-Ang University, 84 Heuksuk-ro, Dongjak-gu, Seoul, 06974, Republic of Korea.
authors: Seung-Yup
authors: SY
authors: Yoo
authors: College of Pharmacy, Chung-Ang University, 84 Heuksuk-ro, Dongjak-gu, Seoul, 06974, Republic of Korea.
authors: Dohyun
authors: D
authors: Shin
authors: College of Pharmacy, Chung-Ang University, 84 Heuksuk-ro, Dongjak-gu, Seoul, 06974, Republic of Korea.
authors: Chung-Lyol
authors: CL
authors: Lee
authors: College of Pharmacy, Chung-Ang University, 84 Heuksuk-ro, Dongjak-gu, Seoul, 06974, Republic of Korea.
authors: Seon-Jeong
authors: SJ
authors: Na
authors: College of Pharmacy, Chung-Ang University, 84 Heuksuk-ro, Dongjak-gu, Seoul, 06974, Republic of Korea.
authors: Yeong Hyo
authors: YH
authors: Kim
authors: College of Pharmacy, Chung-Ang University, 84 Heuksuk-ro, Dongjak-gu, Seoul, 06974, Republic of Korea.
authors: Kanghee
authors: K
authors: Jo
authors: Department of Food Science and Technology, Chung-Ang University, Anseong, 17546, Republic of Korea.
authors: Gyiae
authors: G
authors: Yun
authors: Erom Co., Ltd., Chuncheon, 24441, Republic of Korea.
authors: Joong-Hark
authors: JH
authors: Kim
authors: College of Pharmacy, Chung-Ang University, 84 Heuksuk-ro, Dongjak-gu, Seoul, 06974, Republic of Korea.
authors: Uy Dong
authors: UD
authors: Sohn
authors: College of Pharmacy, Chung-Ang University, 84 Heuksuk-ro, Dongjak-gu, Seoul, 06974, Republic of Korea. jaehwi@cau.ac.kr.
authors: Jaehwi
authors: http://orcid.org/0000-0003-3696-2626
authors: J
authors: Lee
mesh_terms: D000279:Administration, Cutaneous; D000328:Adult; D019540:Area Under Curve; D003358:Cosmetics / Q000008:administration & dosage / Q000494:pharmacology; D004337:Drug Carriers; D005260:Female; D006801:Humans; D020100:Hydrogels / Q000737:chemistry; D008055:Lipids / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry; D010316:Particle Size; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry; D006109:Poaceae / Q000737:chemistry*; D011134:Polysaccharides / Q000008:administration & dosage / Q000494:pharmacology*; D012694:Serine / Q000008:administration & dosage / Q000494:pharmacology*; D012867:Skin / Q000187:drug effects*; D012869:Skin Absorption; D014783:Viscosity; D055815:Young Adult
chemical_list: D003358:Cosmetics; D004337:Drug Carriers; D020100:Hydrogels; D008055:Lipids; D010936:Plant Extracts; D011134:Polysaccharides; D012694:Serine
keywords: Phragmites rhizoma; Reed root extract; Serine; Skin moisturization; Solid lipid nanoparticles