title: New Benzophenones and Xanthones from Cratoxylum sumatranum ssp. neriifolium and Their Antibacterial and Antioxidant Activities.
abstract: Two new benzophenones (1 and 2) and four new xanthones (4-6 and 17) together with 24 known compounds (3, 7-16, and 18-30) were isolated from the roots and twigs of Cratoxylum sumatranum ssp. neriifolium. Their structures were elucidated by spectroscopic methods. Compounds 5 and 26 showed antibacterial activity against Micrococcus luteus, Bacillus cereus, and Staphylococcus epidermis with minimum inhibitory concentrations ranging from 4 to 8 μg/mL, whereas compounds 7, 20, and 26 displayed selective antibacterial activities against Staphylococcus aureus (8 μg/mL), Salmonella typhimurium (4 μg/mL), and Pseudomonas aeruginosa (4 μg/mL), respectively. The radical scavenging effects of some isolated compounds were investigated. Compounds 11 and 21 exhibited potent activity against 2,2-diphenyl-1-picrylhydrazyl (DPPH) with IC50values of 7.0 ± 1.0 and 6.0 ± 0.2 μM, respectively.
authors: Natural Products Research Laboratory, School of Science, Mae Fah Luang University , Tasud, Muang, Chiang Rai 57100, Thailand.
authors: Cholpisut
authors: C
authors: Tantapakul
authors: Natural Products Research Laboratory, School of Science, Mae Fah Luang University , Tasud, Muang, Chiang Rai 57100, Thailand.
authors: Wisanu
authors: W
authors: Maneerat
authors: School of Cosmetic Science, Mae Fah Luang University , Tasud, Muang, Chiang Rai 57100, Thailand.
authors: Tawanun
authors: T
authors: Sripisut
authors: Department of Chemistry, Faculty of Science, Chiang Mai University , Sutep, Muang, Chiang Mai 50200, Thailand.
authors: Thunwadee
authors: T
authors: Ritthiwigrom
authors: Departments of Chemistry and Earth, Ocean & Atmospheric Sciences, University of British Columbia , 2036 Main Mall, Vancouver, BC, Canada V6T 1Z1.
authors: Raymond J
authors: RJ
authors: Andersen
authors: Departments of Chemistry and Earth, Ocean & Atmospheric Sciences, University of British Columbia , 2036 Main Mall, Vancouver, BC, Canada V6T 1Z1.
authors: Ping
authors: P
authors: Cheng
authors: School of Science, University of Phayao , Maeka, Muang, Phayao 56000, Thailand.
authors: Sarot
authors: S
authors: Cheenpracha
authors: Natural Products Research Laboratory, School of Science, Mae Fah Luang University , Tasud, Muang, Chiang Rai 57100, Thailand.
authors: Achara
authors: A
authors: Raksat
authors: Natural Products Research Laboratory, School of Science, Mae Fah Luang University , Tasud, Muang, Chiang Rai 57100, Thailand.
authors: Surat
authors: S
authors: Laphookhieo
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D001409:Bacillus cereus / Q000187:drug effects; D001577:Benzophenones / Q000737:chemistry / Q000494:pharmacology*; D028084:Clusiaceae / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D044004:Xanthones / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D001577:Benzophenones; D010936:Plant Extracts; D044004:Xanthones
keywords: Cratoxylum sumatranum ssp. neriifolium; antibacterial activity; antioxidant activity; benzophenone; xanthone