title: Effect of Guava in Blood Glucose and Lipid Profile in Healthy Human Subjects: A Randomized Controlled Study.
abstract: BACKGROUND
  The fruit ofPsidium guajava (P.guajava)is known to contain free sugars yet the fruit juice showed hypoglycaemic effect. Hypoglycaemic activity of guava leaves has been well documented but not for guava fruit.
  
  
  OBJECTIVE
  So we aimed to evaluate the effect of ripe guava (with peel and without peel) fruit supplementation on blood glucose and lipid profile in healthy human subjects.
  
  
  METHODS
  Randomized Controlled study undertaken in: 1) Baseline; 2) 6 weeks supplementation phase. Forty five healthy MBBS students were included and randomly enrolled into Group A, Group B and Group C. In Baseline phase: Fasting Plasma Glucose (FPG) and serum lipid profile was done in all 3 groups. Group A were supplemented with 400g of ripe guava with peel and group B without peel, for 6 weeks. Rest 15 treated as control i.e., Group C.
  
  
  RESULTS
  Supplementation of ripe guava fruit with peel reduced BMI as well as blood pressure (p<0.05) in group A, whereas the FPG, Total cholesterol, Triglycerides were found significantly increased (p<0.05). Group B registered a significant fall (p<0.05) in BMI as well as blood pressure. Fall in FPG level after guava pulp supplementation was not significant. Serum Total cholesterol, Triglycerides and Low Density Lipoprotein Cholesterol (LDLc) levels decreased significantly (p<0.05) indicating that guava pulp without peel may have a favourable effect on lipid levels and blood sugar as well.
  
  
  CONCLUSIONS
  Guava fruit without peel is more effective in lowering blood sugar as well as serum total cholesterol, triglycerides and LDLc. It increases HDLc levels also.
authors: Assistant Professor, Department of Biochemistry, All India Institute of Medical Sciences (AIIMS) , Sijua, Bhubaneswar, Odisha, India .
authors: Suchitra
authors: S
authors: Kumari
authors: Student, Department of Biochemistry, All India Institute of Medical Sciences (AIIMS) , Sijua, Bhubaneswar, Odisha, India .
authors: R
authors: R
authors: Rakavi
authors: Student, Department of Biochemistry, All India Institute of Medical Sciences (AIIMS) , Sijua, Bhubaneswar, Odisha, India .
authors: Manaswini
authors: M
authors: Mangaraj
keywords: Blood sugar; P guajava; Randomized control trial; Supplementation