title: Podoplanin as Key Player of Tumor Progression and Lymph Vessel Proliferation in Ovarian Cancer.
abstract: Podoplanin plays a key role in tumor progression and metastasis. We evaluated lymphatics proliferation rate and podoplanin expression in tumor cells of ovarian carcinoma.
  
  
  
  Seventy-five paraffin-embedded specimens of ovarian cancer were immunohistochemically assessed in order to quantify peritumoral (LMVDP) and intratumoral (LMVDT) lymphatic microvessel density of proliferating lymphatics and for podoplanin variability in tumor cells.
  
  
  
  LMVDT correlated with proliferating tumor vessels located in the peritumoral area (p=0.024) and with the number of mature vessels located in the intratumoral area (p<0.0001), while LMVDP correlated with peritumoral mature vessels (p<0.000l). Proliferating tumor cells at the invasive front were highly positive for podoplanin. To the best of our knowledge, this study represents the first assessment of lymphatic endothelial cell proliferation correlated with podoplanin expression in tumor cells from ovarian cancer. Our data support podoplanin as a potential target that may help reduce ovarian cancer dissemination and lymphatic metastasis.
authors: Department of Obstetrics and Gynecology, Angiogenesis Research Center, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania.|Department of Obstetrics and Gynecology, Diakonie Klinikum, Schwäbisch Hall, Academic Hospital of the Heidelberg University, Heidelberg, Germany.
authors: Ionut Marcel
authors: IM
authors: Cobec
authors: Department of Obstetrics and Gynecology, Angiogenesis Research Center, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania.
authors: Ioan
authors: I
authors: Sas
authors: Department of Obstetrics and Gynecology, Angiogenesis Research Center, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania.
authors: Laurențiu
authors: L
authors: Pirtea
authors: Department of Microscopic Morphology/Histology, Angiogenesis Research Center, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania ancacimpean1972@yahoo.com.
authors: Anca Maria
authors: AM
authors: Cimpean
authors: Department of Obstetrics and Gynecology, Diakonie Klinikum, Schwäbisch Hall, Academic Hospital of the Heidelberg University, Heidelberg, Germany.
authors: Aurica Elisabeta
authors: AE
authors: Moatar
authors: Department of Microscopic Morphology/Histology, Angiogenesis Research Center, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania.
authors: Raluca Amalia
authors: RA
authors: Ceaușu
authors: Department of Microscopic Morphology/Histology, Angiogenesis Research Center, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania.
authors: Marius
authors: M
authors: Raica
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D005260:Female; D006801:Humans; D019394:Ki-67 Antigen / Q000378:metabolism; D042583:Lymphangiogenesis; D008207:Lymphatic Metastasis / Q000473:pathology*; D042601:Lymphatic Vessels / Q000473:pathology; D008562:Membrane Glycoproteins / Q000378:metabolism*; D010051:Ovarian Neoplasms / Q000378:metabolism* / Q000473:pathology*; D000098853:Podoplanin
chemical_list: D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen; D008562:Membrane Glycoproteins; C117468:PDPN protein, human; D000098853:Podoplanin
keywords: Podoplanin; lymphatic endothelial cells; lymphatic metastasis; ovarian cancer