title: Nanoconfinement's Dramatic Impact on Proton Exchange between Glucose and Water.
abstract: Glucose nanoconfined by solubilization in water-containing AOT (sodium bis(2-ethylhexyl) sulfosuccinate) reverse micelles has been investigated using1H NMR. NMR spectra reveal well-defined signals for the glucose hydroxyl groups that suggest slow chemical exchange between them and the water hydroxyl groups. Using the EXSY (ZZ-exchange) method, the chemical exchange rate from water to glucose hydroxyl groups was measured for glucose in reverse micelles as a function of size (water pool diameter of ∼1-5 nm) at 25 °C. The chemical exchange rates observed in the nanoconfined interior are dramatically slower (5-20 times) than those observed for glucose in bulk aqueous solution at the same concentration as the micelle interior. Exchange rate constants are calculated via a mechanism that accounts for these observations, and implications of these results are presented and discussed.
authors: Department of Chemistry, Colorado State University , Fort Collins, Colorado 80523-1872, United States.
authors: Benjamin P
authors: BP
authors: Wiebenga-Sanford
authors: Department of Chemistry, Colorado State University , Fort Collins, Colorado 80523-1872, United States.
authors: Joseph
authors: J
authors: DiVerdi
authors: Department of Chemistry, Colorado State University , Fort Collins, Colorado 80523-1872, United States.
authors: Christopher D
authors: CD
authors: Rithner
authors: Department of Chemistry, Colorado State University , Fort Collins, Colorado 80523-1872, United States.
authors: Nancy E
authors: NE
authors: Levinger