title: Granulocyte Colony-Stimulating Factor-Producing Gallbladder Cancer.
abstract: We report a case of a granulocyte colony-stimulating factor (G-CSF)-producing gallbladder tumor associated with fever in a middle-aged female. Preoperative blood analysis showed leukocytosis with elevated levels of C-reactive protein and G-CSF. We resected the liver at S4a＋S5, with regional lymph node dissection and partial resection of the duodenum. Histology revealed undifferentiated carcinoma with spindle and giant cells and papillary adenocarcinoma. Immunohistochemistry revealed Stage IIIB G-CSF-producing gallbladder cancer. Postoperatively, leukocyte and serum G-CSF levels decreased to within normal limits. Adjuvant gemcitabine chemotherapy was administered for 16 months, and she has been recurrence-free for 48 months.
authors: Department of Surgery and Iwakuni Clinical Center, National Hospital Organization, Iwakuni, Yamaguchi 740-0041, Japan.nov19841026@yahoo.co.jp.
authors: Nobuhiko
authors: N
authors: Kanaya
authors: Hideki
authors: H
authors: Aoki
authors: Rie
authors: R
authors: Yamasaki
authors: Toshiaki
authors: T
authors: Morihiro
authors: Hitoshi
authors: H
authors: Takeuchi
mesh_terms: D000231:Adenocarcinoma, Papillary / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use; D002277:Carcinoma / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D003841:Deoxycytidine / Q000031:analogs & derivatives / Q000627:therapeutic use; D005260:Female; D005706:Gallbladder Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D016179:Granulocyte Colony-Stimulating Factor / Q000378:metabolism*; D006801:Humans; D008875:Middle Aged; D000093542:Gemcitabine
chemical_list: D000964:Antimetabolites, Antineoplastic; D003841:Deoxycytidine; D016179:Granulocyte Colony-Stimulating Factor; D000093542:Gemcitabine