title: Upregulation of Heme Oxygenase-1 in Response to Wild Thyme Treatment Protects against Hypertension and Oxidative Stress.
abstract: High blood pressure is the most powerful contributor to the cardiovascular morbidity and mortality, and inverse correlation between consumption of polyphenol-rich foods or beverages and incidence of cardiovascular diseases gains more importance. Reactive oxygen species plays an important role in the development of hypertension. We found that wild thyme (a spice plant, rich in polyphenolic compounds) induced a significant decrease of blood pressure and vascular resistance in hypertensive rats. The inverse correlation between vascular resistance and plasma heme oxygenase-1 suggests that endogenous vasodilator carbon monoxide generated by heme oxidation could account for this normalization of blood pressure. Next product of heme oxidation, bilirubin (a chain-breaking antioxidant that acts as a lipid peroxyl radical scavenger), becomes significantly increased after wild thyme treatment and induces the reduction of plasma lipid peroxidation in hypertensive, but not in normotensive rats. The obtained results promote wild thyme as useful supplement for cardiovascular interventions.
authors: Institute for Medical Research, University of Belgrade, Dr. Subotica 4, P.O. Box 102, 11129 Belgrade, Serbia.
authors: Nevena
authors: 0000-0001-5356-8706
authors: N
authors: Mihailovic-Stanojevic
authors: Institute for Medical Research, University of Belgrade, Dr. Subotica 4, P.O. Box 102, 11129 Belgrade, Serbia.
authors: Zoran
authors: Z
authors: Miloradović
authors: Institute for Medical Research, University of Belgrade, Dr. Subotica 4, P.O. Box 102, 11129 Belgrade, Serbia.
authors: Milan
authors: 0000-0001-8683-5751
authors: M
authors: Ivanov
authors: Faculty of Technology and Metallurgy, Department of Chemical Engineering, University of Belgrade, Karnegijeva 4, Belgrade, Serbia.
authors: Branko
authors: B
authors: Bugarski
authors: Institute for Medical Research, University of Belgrade, Dr. Subotica 4, P.O. Box 102, 11129 Belgrade, Serbia.
authors: Đurđica
authors: Đ
authors: Jovović
authors: Institute for Medical Research, University of Belgrade, Dr. Subotica 4, P.O. Box 102, 11129 Belgrade, Serbia.
authors: Danijela
authors: 0000-0001-5746-746X
authors: D
authors: Karanović
authors: Institute for Medical Research, University of Belgrade, Dr. Subotica 4, P.O. Box 102, 11129 Belgrade, Serbia.
authors: Una-Jovana
authors: UJ
authors: Vajić
authors: Faculty of Food Technology and Biotechnology, University of Zagreb, Pierottijeva 6, 10 000 Zagreb, Croatia.
authors: Draženka
authors: 0000-0002-9062-1673
authors: D
authors: Komes
authors: Institute for Medical Research, University of Belgrade, Dr. Subotica 4, P.O. Box 102, 11129 Belgrade, Serbia.
authors: Jelica
authors: J
authors: Grujić-Milanović
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry; D001663:Bilirubin / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects; D002374:Catalase / Q000378:metabolism; D004797:Enzyme-Linked Immunosorbent Assay; D004912:Erythrocytes / Q000201:enzymology / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D006339:Heart Rate / Q000187:drug effects; D051547:Heme Oxygenase-1 / Q000032:analysis / Q000097:blood*; D006439:Hemodynamics / Q000187:drug effects; D006973:Hypertension / Q000378:metabolism / Q000517:prevention & control*; D007668:Kidney / Q000201:enzymology / Q000378:metabolism; D008099:Liver / Q000201:enzymology / Q000378:metabolism; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D011918:Rats, Inbred SHR; D013482:Superoxide Dismutase / Q000378:metabolism; D046930:Thymus Plant / Q000737:chemistry* / Q000378:metabolism; D015854:Up-Regulation / Q000187:drug effects
chemical_list: D000975:Antioxidants; D010936:Plant Extracts; D002374:Catalase; D005979:Glutathione Peroxidase; D051547:Heme Oxygenase-1; D013482:Superoxide Dismutase; D001663:Bilirubin