title: Osseointegration of three-dimensional designed titanium implants manufactured by selective laser melting.
abstract: The selective laser melting (SLM) technique is a recent additive manufacturing (AM) technique. Several studies have reported success in the SLM-based production of biocompatible orthopaedic implants and three-dimensional bone defect constructs. In this study, we evaluated the surface properties and biocompatibility of an SLM titanium implant in vitro and compared them with those of a machined (MA) titanium control surface. In addition, we evaluated the osseointegration capability of the SLM implants in vivo and compared it with those of MA and Nobel-speedy (Nobel-S) implants. SLM microtopographical surface analysis revealed porous and high roughness with varied geometry compared with a smooth surface in MA Ti samples but with similar favourable wettability. Osteoblast proliferation and alkaline phosphatase activity were significantly enhanced on the SLM surface. Histological analysis of the bone-implant contact ratio revealed no significant difference among SLM, MA, and Nobel-S implants. Micro-CT assessment indicated that there was no significant difference in bone volume fraction around the implant among SLM implants and other types of surface modification implants. The removal torque value measurement of SLM implants was significantly lower that of than Nobel-S implants P < 0.001 and higher than that of MA implants. The study demonstrates the capability of SLM implants to integrate with living bone. The SLM technique holds promise as a new dental implant manufacturing technique.
authors: Department of Oral Implantology, Guangdong Provincial Key Laboratory of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, People's Republic of China.
authors: Algabri
authors: A
authors: Shaoki
authors: Jia-Yun
authors: JY
authors: Xu
authors: Haipeng
authors: H
authors: Sun
authors: Xian-Shuai
authors: XS
authors: Chen
authors: Jianglin
authors: J
authors: Ouyang
authors: Xiu-Mei
authors: XM
authors: Zhuang
authors: Fei-Long
authors: FL
authors: Deng
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000473:pathology; D018786:Bone Substitutes / Q000737:chemistry* / Q000494:pharmacology; D001842:Bone and Bones / Q000473:pathology; D002448:Cell Adhesion / Q000187:drug effects; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D015921:Dental Implants; D004285:Dogs; D007834:Lasers; D051379:Mice; D008855:Microscopy, Electron, Scanning; D016348:Osseointegration / Q000187:drug effects; D044367:Phase Transition / Q000528:radiation effects; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry*; D055114:X-Ray Microtomography
chemical_list: D018786:Bone Substitutes; D015921:Dental Implants; D014025:Titanium