title: Maternal plasma antioxidant status in the first trimester of pregnancy and development of obstetric complications.
abstract: Oxidative stress is present in pregnancy complications. However, it is unknown if early maternal antioxidant status could influence later development of complications. The use of assisted reproduction techniques (ART) is rising due to the delay of first pregnancy and there is scarce information on its influence on oxidative balance.
  
  
  
  To assess the possible relationship between maternal plasma antioxidant status in first trimester of gestation with later development of pregnancy complications, evaluating the influence of ART and nutrition.
  
  
  
  Plasma from 98 healthy pregnant women was obtained at week 10, nutrition questionnaires filled and women were followed until delivery. We evaluated biomarkers of oxidative damage (carbonyls, malondialdehyde-MDA), antioxidants (thiols, reduced glutathione, phenolic compounds, catalase and superoxide dismutase activities) by spectrophotometry/fluorimetry and melatonin (ELISA). Antioxidant status score (Antiox-S) was calculated as the computation of antioxidants. Diet-antioxidants relationship was evaluated through multiple correspondence analysis.
  
  
  
  Melatonin and carbonyls exhibited a negative correlation. No difference in oxidative damage was found between groups, but Antiox-S was significantly lower in women who developed complications. No differences in oxidative damage or Antiox-S were found between ART and no-ART pregnancies. High consumption of foods of vegetable origin cluster with high plasma levels of phenolic compounds and with high Antiox-S.
  
  
  
  In early normal gestation, low plasma antioxidant status, assessed through a global score, associates with later development of pregnancy complications. Larger population studies could help to determine the value of Antiox-S as predictive tool and the relevance of nutrition on maternal antioxidant status.
authors: Department of Physiology, Faculty of Medicine, Universidad Autónoma de Madrid, Spain.
authors: David
authors: D
authors: Ramiro-Cortijo
authors: Department of Agricultural and Food Chemistry-CIAL, Faculty of Sciences, Universidad Autónoma de Madrid, Spain.
authors: Teresa
authors: T
authors: Herrera
authors: Department of Physiology, Faculty of Medicine, Universidad Autónoma de Madrid, Spain.
authors: Pilar
authors: P
authors: Rodríguez-Rodríguez
authors: Department of Physiology, Faculty of Medicine, Universidad Autónoma de Madrid, Spain.
authors: Ángel L
authors: ÁL
authors: López De Pablo
authors: Obstetrics and Gynecology Service, La Paz University Hospital, Universidad Autónoma de Madrid, Spain.
authors: María
authors: M
authors: De La Calle
authors: Department of Preventive Medicine, Public Health & Microbiology, Faculty of Medicine, Universidad Autónoma de Madrid, Spain.
authors: María R
authors: MR
authors: López-Giménez
authors: Department of Biology, Faculty of Sciences, Universidad Autónoma de Madrid, Spain.
authors: Ana I
authors: AI
authors: Mora-Urda
authors: Department of Physiology, Faculty of Medicine, Universidad Autónoma de Madrid, Spain.
authors: Perla Y
authors: PY
authors: Gutiérrez-Arzapalo
authors: Laboratory Medicine Service, La Paz University Hospital, Universidad Autónoma de Madrid, Spain.
authors: Rubén
authors: R
authors: Gómez-Rioja
authors: Department of Agricultural and Food Chemistry-CIAL, Faculty of Sciences, Universidad Autónoma de Madrid, Spain.
authors: Yolanda
authors: Y
authors: Aguilera
authors: Department of Agricultural and Food Chemistry-CIAL, Faculty of Sciences, Universidad Autónoma de Madrid, Spain.
authors: María A
authors: MA
authors: Martín-Cabrejas
authors: Department of Physiology, Faculty of Medicine, Universidad Autónoma de Madrid, Spain.
authors: Luis
authors: L
authors: Condezo-Hoyos
authors: Department of Physiology, Faculty of Medicine, Universidad Autónoma de Madrid, Spain.
authors: M Carmen
authors: MC
authors: González
authors: Department of Biology, Faculty of Sciences, Universidad Autónoma de Madrid, Spain.
authors: Pilar
authors: P
authors: Montero
authors: Department of Biological and Health Psychology, Faculty of Psychology, Universidad Autónoma de Madrid, Spain.
authors: Bernardo
authors: B
authors: Moreno-Jiménez
authors: Department of Physiology, Faculty of Medicine, Universidad Autónoma de Madrid, Spain. Electronic address: silvia.arribas@uam.es.
authors: Silvia M
authors: SM
authors: Arribas
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D002374:Catalase / Q000378:metabolism; D004032:Diet; D005260:Female; D005978:Glutathione / Q000097:blood; D005979:Glutathione Peroxidase / Q000378:metabolism; D006801:Humans; D008315:Malondialdehyde / Q000097:blood; D008550:Melatonin / Q000097:blood; D018384:Oxidative Stress / Q000502:physiology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood*; D011261:Pregnancy Trimester, First / Q000097:blood*; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D015415:Biomarkers; D008315:Malondialdehyde; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005978:Glutathione; D008550:Melatonin
keywords: Antioxidants; Biomarker; Obstetric complications; Plasma; Pregnancy