title: Risk of lung cancer in Parkinson's disease.
abstract: Recently, growing evidence has revealed the significant association between Parkinson's disease (PD) and cancer. However, controversy still exists concerning the association between PD and lung cancer. A comprehensive article search for relevant studies published was performed using the following online databases: PubMed, Web of Science and Embase up to August 31, 2016. The pooled risk ratio (RR) and their 95 % confidence intervals (CI) were calculated using the method of inverse variance with the random-effects model. Fifteen studies comprising 348,780 PD patients were included in this study. The pooled result indicated that patients with PD were significantly associated with a decreased risk of lung cancer (RR: 0.53, 95% CI: 0.41-0.70, P < 0.001). In addition, subgroup analyses performed in Western population also confirmed the significant inverse relationship between PD and risk of lung cancer (RR: 0.48, 95% CI: 0.39-0.60, P < 0.001). In the subgroup analysis, a reduced risk of lung cancer in PD patients from Western population was consistent regardless of study design, gender, or study quality. In conclusion, PD patients were significantly associated with a reduced risk of lung cancer in Western population. The relationship between them in Asian population needs to be confirmed by future studies.
authors: Department of Neurology, The First Affiliated Hospital of China Medical University, Shenyang City 110001, PR China.
authors: Xin
authors: X
authors: Xie
authors: Department of Neurology, The First Affiliated Hospital of China Medical University, Shenyang City 110001, PR China.
authors: Xiaoguang
authors: X
authors: Luo
authors: Clinics of the People's Armed Police Command College, Tianjin City, 300000, PR China.
authors: Mingliang
authors: M
authors: Xie
authors: Department of Neurology, The First Affiliated Hospital of China Medical University, Shenyang City 110001, PR China.
authors: Yang
authors: Y
authors: Liu
authors: Department of Neurology, The First Affiliated Hospital of China Medical University, Shenyang City 110001, PR China.
authors: Ting
authors: T
authors: Wu
mesh_terms: D002170:Canada / Q000453:epidemiology; D005260:Female; D006801:Humans; D007557:Israel / Q000453:epidemiology; D007564:Japan / Q000453:epidemiology; D008175:Lung Neoplasms / Q000453:epidemiology*; D008297:Male; D016017:Odds Ratio; D010300:Parkinson Disease / Q000453:epidemiology*; D013548:Sweden / Q000453:epidemiology; D013624:Taiwan / Q000453:epidemiology; D006113:United Kingdom / Q000453:epidemiology; D014481:United States / Q000453:epidemiology
keywords: Parkinson’s disease; lung neoplasms; meta-analysis; risk