title: Terahertz reflectometry imaging for low and high grade gliomas.
abstract: Gross total resection (GTR) of glioma is critical for improving the survival rate of glioma patients. One of the greatest challenges for achieving GTR is the difficulty in discriminating low grade tumor or peritumor regions that have an intact blood brain barrier (BBB) from normal brain tissues and delineating glioma margins during surgery. Here we present a highly sensitive, label-free terahertz reflectometry imaging (TRI) that overcomes current key limitations for intraoperative detection of World Health Organization (WHO) grade II (low grade), and grade III and IV (high grade) gliomas. We demonstrate that TRI provides tumor discrimination and delineation of tumor margins in brain tissues with high sensitivity on the basis of Hematoxylin and eosin (H&E) stained image. TRI may help neurosurgeons to remove gliomas completely by providing visualization of tumor margins in WHO grade II, III, and IV gliomas without contrast agents, and hence, improve patient outcomes.
authors: YUHS-KRIBB Medical Convergence Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea.
authors: Young Bin
authors: YB
authors: Ji
authors: YUHS-KRIBB Medical Convergence Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea.
authors: Seung Jae
authors: SJ
authors: Oh
authors: Department of Neurosurgery, Brain Tumor Center, Brain Research Institute, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
authors: Seok-Gu
authors: SG
authors: Kang
authors: Department of Mechanical Engineering, Yonsei University, Seoul, Republic of Korea.
authors: Jung
authors: J
authors: Heo
authors: YUHS-KRIBB Medical Convergence Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea.|Applied Electromagnetic Wave Research Center, Korea Electrotechnology Research Institute, Ansan, Republic of Korea.
authors: Sang-Hoon
authors: SH
authors: Kim
authors: YUHS-KRIBB Medical Convergence Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea.
authors: Yuna
authors: Y
authors: Choi
authors: Department of Mechanical Engineering, Yonsei University, Seoul, Republic of Korea.
authors: Seungri
authors: S
authors: Song
authors: Severance Biomedical Science Institute, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
authors: Hye Young
authors: HY
authors: Son
authors: Department of Pathology, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
authors: Se Hoon
authors: SH
authors: Kim
authors: Department of Neurosurgery, Brain Tumor Center, Brain Research Institute, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
authors: Ji Hyun
authors: JH
authors: Lee
authors: Department of Chemical and Biomolecular Engineering, Yonsei University, Seoul, Republic of Korea.
authors: Seung Joo
authors: SJ
authors: Haam
authors: YUHS-KRIBB Medical Convergence Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea.|Department of Radiology, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
authors: Yong Min
authors: YM
authors: Huh
authors: Department of Neurosurgery, Brain Tumor Center, Brain Research Institute, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
authors: Jong Hee
authors: JH
authors: Chang
authors: Department of Mechanical Engineering, Yonsei University, Seoul, Republic of Korea.
authors: Chulmin
authors: C
authors: Joo
authors: YUHS-KRIBB Medical Convergence Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea.|Department of Radiology, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
authors: Jin-Suck
authors: JS
authors: Suh
mesh_terms: D000818:Animals; D005910:Glioma / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009374:Neoplasms, Experimental / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology; D055069:Terahertz Imaging / Q000379:methods*