title: Interleukin-6 in Sera of Mice Inoculated with Group A Streptococcus and Cultural Supernatants.
abstract: Dynamics of IL-6 level was studied in blood serum of CBA mice receiving intraperitoneal injections of killed and live culture of group A Streptococcus and its supernatants. It was found that administration of killed culture was followed by a significant rise in IL-6 level (by 4.7 times in 1 h and by 9.3 times in 5 h in comparison with the control). By 24 h, cytokine content was below the control. The highest levels of IL-6 were found after treatment with supernatants of Streptococcus cultures (by 10.5 times in 1 h and by 14.9 times in 5 h, in comparison with the control). Administration of live culture was accompanied by an increase in IL-6 concentration by 3.2 times in 3 h. In this experimental series, the maximum level of IL-6 was found in 48 h (by 5.2 times), and then it gradually decreased below the control. Different dynamics of changes in IL-6 level after administration of killed and live cultures of group A Streptococcus may suggests that they activate different signal pathways.
authors: Laboratory of Microbiology of Latent Infections, N. F. Gamaleya Federal Research Center of Epidemiology and Microbiology, Ministry of Healthcare of the Russian Federation, Moscow, Russia. dansen@inbox.ru.
authors: T A
authors: TA
authors: Danilova
authors: Laboratory of Microbiology of Latent Infections, N. F. Gamaleya Federal Research Center of Epidemiology and Microbiology, Ministry of Healthcare of the Russian Federation, Moscow, Russia.
authors: G A
authors: GA
authors: Danilina
authors: Laboratory of Microbiology of Latent Infections, N. F. Gamaleya Federal Research Center of Epidemiology and Microbiology, Ministry of Healthcare of the Russian Federation, Moscow, Russia.
authors: A A
authors: AA
authors: Adzhieva
authors: Laboratory of Microbiology of Latent Infections, N. F. Gamaleya Federal Research Center of Epidemiology and Microbiology, Ministry of Healthcare of the Russian Federation, Moscow, Russia.
authors: A G
authors: AG
authors: Minko
authors: Laboratory of Microbiology of Latent Infections, N. F. Gamaleya Federal Research Center of Epidemiology and Microbiology, Ministry of Healthcare of the Russian Federation, Moscow, Russia.
authors: V G
authors: VG
authors: Zhukhovitskii
mesh_terms: D000818:Animals; D017077:Culture Media, Conditioned / Q000494:pharmacology*; D007114:Immunization; D007274:Injections, Intraperitoneal; D015850:Interleukin-6 / Q000096:biosynthesis / Q000097:blood* / Q000378:metabolism; D007700:Kinetics; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D013297:Streptococcus pyogenes / Q000737:chemistry / Q000276:immunology*; D013997:Time Factors
chemical_list: D017077:Culture Media, Conditioned; D015850:Interleukin-6; C577686:interleukin-6, mouse
keywords: cytokines; group A streptococcus; immune response; interleukin-6