title: Voxelwise analysis of simultaneously acquired and spatially correlated18F-fluorodeoxyglucose (FDG)-PET and intravoxel incoherent motion metrics in breast cancer.
abstract: Diffusion-weighted imaging (DWI) and18F-fluorodeoxyglucose-positron emission tomography (18F-FDG-PET) independently correlate with malignancy in breast cancer, but the relationship between their structural and metabolic metrics is not completely understood. This study spatially correlates diffusion, perfusion, and glucose avidity in breast cancer with simultaneous PET/MR imaging and compares correlations with clinical prognostics.
  
  
  
  In this Health Insurance Portability and Accountability Act-compliant prospective study, with written informed consent and approval of the institutional review board and using simultaneously acquired FDG-PET and DWI, tissue diffusion (Dt), and perfusion fraction (fp) from intravoxel incoherent motion (IVIM) analysis were registered to FDG-PET within 14 locally advanced breast cancers. Lesions were analyzed using 2D histograms and correlation coefficients between Dt, fp, and standardized uptake value (SUV). Correlations were compared with prognostics from biopsy, metastatic burden from whole-body PET, and treatment history.
  
  
  
  SUV||Dtcorrelation coefficient significantly distinguished treated (0.11 ± 0.24) from nontreated (-0.33 ± 0.26) patients (P = 0.005). SUV||fpcorrelations were on average negative for the whole cohort (-0.17 ± 0.13).
  
  
  
  Simultaneously acquired and registered FDG-PET/DWI allowed quantifiable descriptions of breast cancer microenvironments that may provide a framework for monitoring and predicting response to treatment. Magn Reson Med 78:1147-1156, 2017. © 2016 International Society for Magnetic Resonance in Medicine.
authors: Department of Radiology, New York University School of Medicine, New York, New York, USA.|Center for Advanced Imaging Innovation and Research (CAI2R), NYU Langone Medical Center, New York, New York, USA.|Vanderbilt University Institute of Imaging Science, Nashville, Tennessee, USA.
authors: Jason
authors: J
authors: Ostenson
authors: Department of Radiology, New York University School of Medicine, New York, New York, USA.|Center for Advanced Imaging Innovation and Research (CAI2R), NYU Langone Medical Center, New York, New York, USA.
authors: Akshat C
authors: AC
authors: Pujara
authors: Department of Radiology, New York University School of Medicine, New York, New York, USA.|Center for Advanced Imaging Innovation and Research (CAI2R), NYU Langone Medical Center, New York, New York, USA.
authors: Artem
authors: A
authors: Mikheev
authors: Department of Radiology, New York University School of Medicine, New York, New York, USA.|Center for Advanced Imaging Innovation and Research (CAI2R), NYU Langone Medical Center, New York, New York, USA.
authors: Linda
authors: L
authors: Moy
authors: Department of Radiology, New York University School of Medicine, New York, New York, USA.|Center for Advanced Imaging Innovation and Research (CAI2R), NYU Langone Medical Center, New York, New York, USA.
authors: Sungheon G
authors: SG
authors: Kim
authors: Department of Radiology, New York University School of Medicine, New York, New York, USA.|Center for Advanced Imaging Innovation and Research (CAI2R), NYU Langone Medical Center, New York, New York, USA.
authors: Amy N
authors: AN
authors: Melsaether
authors: Perlmutter Cancer Center, NYU Langone Medical Center, New York, New York, USA.|Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
authors: Komal
authors: K
authors: Jhaveri
authors: Perlmutter Cancer Center, NYU Langone Medical Center, New York, New York, USA.
authors: Sylvia
authors: S
authors: Adams
authors: Siemens Healthcare, New York, New York, USA.
authors: David
authors: D
authors: Faul
authors: Siemens Healthcare, New York, New York, USA.
authors: Christopher
authors: C
authors: Glielmi
authors: Siemens Healthcare, New York, New York, USA.|Siemens Healthcare, Erlangen, Germany.
authors: Christian
authors: C
authors: Geppert
authors: Siemens Healthcare, Erlangen, Germany.
authors: Thorsten
authors: T
authors: Feiweier
authors: Department of Radiology, New York University School of Medicine, New York, New York, USA.|Center for Advanced Imaging Innovation and Research (CAI2R), NYU Langone Medical Center, New York, New York, USA.
authors: Kimberly
authors: K
authors: Jackson
authors: Department of Radiology, New York University School of Medicine, New York, New York, USA.|Center for Advanced Imaging Innovation and Research (CAI2R), NYU Langone Medical Center, New York, New York, USA.
authors: Gene Y
authors: GY
authors: Cho
authors: Department of Radiology, New York University School of Medicine, New York, New York, USA.|Center for Advanced Imaging Innovation and Research (CAI2R), NYU Langone Medical Center, New York, New York, USA.
authors: Fernando E
authors: FE
authors: Boada
authors: Department of Radiology, New York University School of Medicine, New York, New York, USA.|Center for Advanced Imaging Innovation and Research (CAI2R), NYU Langone Medical Center, New York, New York, USA.
authors: Eric E
authors: EE
authors: Sigmund
mesh_terms: D000328:Adult; D000368:Aged; D001940:Breast / Q000000981:diagnostic imaging*; D001943:Breast Neoplasms / Q000000981:diagnostic imaging*; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008875:Middle Aged; D009068:Movement / Q000502:physiology; D049268:Positron-Emission Tomography / Q000379:methods*
chemical_list: D019788:Fluorodeoxyglucose F18
keywords: 18F-fluorodeoxyglucose-positron emission tomography; breast cancer; diffusion; intravoxel incoherent motion; perfusion