title: Repair of rotator cuff injuries using different composites.
abstract: OBJECTIVE
  Rotator cuff repairs have shown a high level of re-ruptures. It is hypothesised that the use of rhBMP-2 in a carrier could improve the biomechanical and histological properties of the repair.
  
  
  METHODS
  Controlled experimental study conducted on 40 rats with section and repair of the supraspinatus tendon and randomisation to one of five groups: Group 1 (control) only suture; Group 2 (double control), suture and alginate-chitin carrier; Group 3 (alginate-control), the rhBMP-2 was added to the alginate; Group 4 (chitin-control) application of the rhBMP-2 to the chitin, and Group 5 (double sample): The two components of the carrier (alginate and chitin) have rhBMP-2. A biomechanical and histological analysis was performed at 4 weeks.
  
  
  RESULTS
  A gap was observed in all cases 4 weeks after supraspinatus detachment. The re-rupture rate was 7.5%, with 20% of them in the control-alginate Group. Histologically the best results were obtained in the double sample group: 4.5 (3.3-5.0). Double sample were also able to support higher loads to failure: 62.9N (59.8 to 69.4) with lower rigidity 12.7 (9.7 to 15.9).
  
  
  CONCLUSIONS
  The use of alginate-chitin carrier with rhBMP-2 improves the biomechanical and histological properties of the repair site in a chronic rotator cuff tear.
authors: Unidad de Cirugía de Hombro y Codo, Servicio de Traumatología y Cirugía Ortopédica, Hospital Clínico San Carlos, Madrid, España. Electronic address: yaizalopiz@gmail.com.
authors: Y
authors: Y
authors: Lopiz
authors: Unidad de Cirugía de Hombro y Codo, Servicio de Traumatología y Cirugía Ortopédica, Hospital Clínico San Carlos, Madrid, España.
authors: C
authors: C
authors: Arvinius
authors: Unidad de Cirugía de Hombro y Codo, Servicio de Traumatología y Cirugía Ortopédica, Hospital Clínico San Carlos, Madrid, España.
authors: C
authors: C
authors: García-Fernández
authors: Unidad de Cirugía Experimental, Hospital Clínico San Carlos, Madrid, España.
authors: M C
authors: MC
authors: Rodriguez-Bobada
authors: Unidad de Cirugía Experimental, Hospital Clínico San Carlos, Madrid, España.
authors: P
authors: P
authors: González-López
authors: Instituto de Estudios Biofuncionales, Universidad Complutense, Madrid, España.
authors: A
authors: A
authors: Civantos
authors: Unidad de Cirugía de Hombro y Codo, Servicio de Traumatología y Cirugía Ortopédica, Hospital Clínico San Carlos, Madrid, España.
authors: F
authors: F
authors: Marco
mesh_terms: D000464:Alginates; D000818:Animals; D001672:Biocompatible Materials; D001696:Biomechanical Phenomena; D055396:Bone Morphogenetic Protein 2 / Q000008:administration & dosage* / Q000627:therapeutic use; D002686:Chitin; D004337:Drug Carriers; D020723:Glucuronic Acid; D006603:Hexuronic Acids; D006801:Humans; D008297:Male; D019637:Orthopedic Procedures / Q000379:methods*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000627:therapeutic use; D012008:Recurrence; D000070636:Rotator Cuff Injuries / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D016212:Transforming Growth Factor beta / Q000008:administration & dosage* / Q000627:therapeutic use; D016474:Weight-Bearing
chemical_list: D000464:Alginates; D001672:Biocompatible Materials; D055396:Bone Morphogenetic Protein 2; D004337:Drug Carriers; D006603:Hexuronic Acids; D011994:Recombinant Proteins; D016212:Transforming Growth Factor beta; C499469:recombinant human bone morphogenetic protein-2; D002686:Chitin; D020723:Glucuronic Acid
keywords: Biomateriales; Biomaterials; Bone morphogenetic protein; Ingeniería tisular; Manguito rotador; Proteína morfogenética ósea; Repair; Reparación; Rotator cuff; Tissue engineering