title: Platelet activating factor: A potential biomarker in acute coronary syndrome?
abstract: Platelet activating factor (PAF) is a potent pro-inflammatory negotiator that shows distinct spectrum of biological and pharmacological effects. Importantly, it participates in a wide range of pathophysiological conditions. In cardiovascular system, PAF has been shown to have an important role in platelet and neutrophil aggregation, vascular permeability, microvascular leakage, thrombus formation, leukocyte adhesion to the endothelial cells, and initiation and progression of atherosclerosis. The purpose of this article was to review the PAF, a family of lipids that is associated with the pathology of coronary artery diseases due to their association with leading etiological mechanisms such as inflammation, endothelial dysfunction, oxidative and nitrosative stress, and platelet reactivity. This review further provides information about PAF and its potential role as a key contributor to the pathogenesis of cardiovascular disorders.
authors: Department of Pharmacy Practice, JSS College of Pharmacy (Jagadguru Sri Shivarathreeswara University, Mysore), Udhagamandalam, Tamil Nadu, India.
authors: Anand Vijaya Kumar
authors: http://orcid.org/0000-0003-1912-1323
authors: AV
authors: Palur Ramakrishnan
authors: Department of Pharmacy Practice, JSS College of Pharmacy (Jagadguru Sri Shivarathreeswara University, Mysore), Udhagamandalam, Tamil Nadu, India.
authors: Treesa P
authors: TP
authors: Varghese
authors: Department of Pharmacy Practice, JSS College of Pharmacy (Jagadguru Sri Shivarathreeswara University, Mysore), Udhagamandalam, Tamil Nadu, India.
authors: Sreedevi
authors: S
authors: Vanapalli
authors: Department of Pharmacy Practice, JSS College of Pharmacy (Jagadguru Sri Shivarathreeswara University, Mysore), Udhagamandalam, Tamil Nadu, India.
authors: Narayanan K
authors: NK
authors: Nair
authors: Department of Pharmacy Practice, JSS College of Pharmacy (Jagadguru Sri Shivarathreeswara University, Mysore), Udhagamandalam, Tamil Nadu, India.
authors: Menge Denis
authors: MD
authors: Mingate
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood* / Q000175:diagnosis; D000818:Animals; D015415:Biomarkers / Q000097:blood; D001792:Blood Platelets / Q000378:metabolism*; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D010972:Platelet Activating Factor / Q000378:metabolism*; D015539:Platelet Activation; D011237:Predictive Value of Tests; D011379:Prognosis; D015398:Signal Transduction
chemical_list: D015415:Biomarkers; D018836:Inflammation Mediators; D010972:Platelet Activating Factor
keywords: Acute coronary syndrome; Endothelial dysfunction; Inflammation; Oxidative and nitrosative stress; Platelet activating factor; Platelet reactivity