title: Polyanionic Biopolymers for the Delivery of Pt(II) Cationic Antiproliferative Complexes.
abstract: Phenanthriplatin, that is, (SP-4-3)-diamminechlorido(phenanthridine)platinum(II) nitrate, an effective antitumor cationic Pt(II) complex, was loaded on negatively charged dextran sulfate (DS) as a model vector for drug deliveryviaelectrostatic interactions. The free complex and the corresponding conjugate withDSwere tested on two standard human tumor cell lines, namely, ovarian A2780 and colon HCT 116, and on several malignant pleural mesothelioma cell lines (namely, epithelioid BR95, mixed/biphasic MG06, sarcomatoid MM98, and sarcomatoid cisplatin-resistant MM98R). Thein vitroresults suggest that the conjugate releases the active metabolite phenanthriplatin with a biphasic fashion. In these experimental conditions, the conjugate is slightly less active than free phenanthriplatin; but both exhibited antiproliferative potency higher than the reference metallodrug cisplatin and were able to overcome the acquired cisplatin chemoresistance in MM98R cells.
authors: Dipartimento di Scienze e Innovazione Tecnologica, Università del Piemonte Orientale, Viale Michel 11, 15121 Alessandria, Italy.
authors: Mauro
authors: 0000-0002-4732-7508
authors: M
authors: Ravera
authors: Dipartimento di Scienze e Innovazione Tecnologica, Università del Piemonte Orientale, Viale Michel 11, 15121 Alessandria, Italy.
authors: Elisabetta
authors: 0000-0002-1181-1955
authors: E
authors: Gabano
authors: Dipartimento di Scienze e Innovazione Tecnologica, Università del Piemonte Orientale, Viale Michel 11, 15121 Alessandria, Italy.
authors: Ilaria
authors: 0000-0003-2174-508X
authors: I
authors: Zanellato
authors: Dipartimento di Scienze e Innovazione Tecnologica, Università del Piemonte Orientale, Viale Michel 11, 15121 Alessandria, Italy.
authors: Elena
authors: 0000-0002-4493-7124
authors: E
authors: Perin
authors: Dipartimento di Scienze e Innovazione Tecnologica, Università del Piemonte Orientale, Viale Michel 11, 15121 Alessandria, Italy.
authors: Aldo
authors: 0000-0003-0279-6180
authors: A
authors: Arrais
authors: Dipartimento di Scienze e Innovazione Tecnologica, Università del Piemonte Orientale, Viale Michel 11, 15121 Alessandria, Italy.
authors: Domenico
authors: 0000-0002-6706-9454
authors: D
authors: Osella