title: Noninvasive Regional Aortic Stiffness for Monitoring the Early Stage of Abdominal Aortic Aneurysm in Mice.
abstract: BACKGROUND
  Abdominal aortic aneurysm (AAA) affects more than 5% of the population in developed countries. To study the formation and progression of AAA, we developed a non-invasive method to analyse regional aortic stiffness to monitor the formation and progression of AAA.
  
  
  METHODS
  Saline or Angiotensin II (AngII) was subcutaneously infused in apolipoprotein E knockout (ApoE-/-) mice for 28 days; a high-resolution imaging system was used to identify changes in arterial stiffness measured by pulse-wave velocity (PWV) and aortic lumen diameter in the suprarenal aorta.
  
  
  RESULTS
  Both regional PWV and luminal diameter in the suprarenal aorta did not change significantly in saline-treated ApoE-/-mice for 28 days. In contrast, AngII treatment for 28 days rapidly increased both regional PWV and luminal diameter. The difference in luminal diameter could be identified at 14 days. However, regional PWV significantly increased within the first 7 days after AngII perfusion as compared with saline treatment. However, in ApoE-/-diabetic mice, both regional PWV and aortic diameter did not differ between AngII and saline treatment at 7 or 28 days.
  
  
  CONCLUSIONS
  Regional PWV may be used to monitor AAA development and was improved after AngII infusion in ApoE-/-mice.
authors: The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health; The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Qilu Hospital of Shandong University, Jinan, Shandong, China.
authors: Qiulun
authors: Q
authors: Lu
authors: Department of General Surgery, Virtual Laboratory, Qilu Hospital of Shandong University, Jinan, Shandong, China.
authors: Xiuxin
authors: X
authors: Jiang
authors: The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health; The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Qilu Hospital of Shandong University, Jinan, Shandong, China.
authors: Cheng
authors: C
authors: Zhang
authors: Plastic Surgery Institute of Weifang Medical University, Weifang, Shandong, China.
authors: Wei
authors: W
authors: Zhang
authors: The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health; The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Qilu Hospital of Shandong University, Jinan, Shandong, China. Electronic address: zhangwencheng@sdu.edu.cn.
authors: Wencheng
authors: W
authors: Zhang
mesh_terms: D000818:Animals; D017544:Aortic Aneurysm, Abdominal / Q000139:chemically induced / Q000235:genetics / Q000503:physiopathology*; D001057:Apolipoproteins E / Q000235:genetics; D048909:Diabetes Complications / Q000235:genetics / Q000503:physiopathology*; D003921:Diabetes Mellitus, Experimental / Q000235:genetics / Q000503:physiopathology*; D051379:Mice; D018345:Mice, Knockout; D063177:Pulse Wave Analysis; D059289:Vascular Stiffness
chemical_list: D001057:Apolipoproteins E
keywords: Abdominal aortic aneurysm; Aortic stiffness; Regional pulse-wave velocity (PWV)