title: Lipid membrane-assisted condensation and assembly of amphiphilic Janus particles.
abstract: Amphiphilic Janus particles self-assemble into complex metastructures, but little is known about how their assembly might be modified by weak interactions with a nearby biological membrane surface. Here, we report an integrated experimental and molecular dynamics simulation study to investigate the self-assembly of amphiphilic Janus particles on a lipid membrane. We created an experimental system in which Janus particles are allowed to self-assemble in the same medium where zwitterionic lipids form giant unilamellar vesicles (GUVs). Janus particles spontaneously concentrated on the inner leaflet of the GUVs. They exhibited biased orientation and heterogeneous rotational dynamics as revealed by single particle rotational tracking. The combined experimental and simulation results show that Janus particles concentrate on the lipid membranes due to weak particle-lipid attraction, whereas the biased orientation of particles is driven predominantly by inter-particle interactions. This study demonstrates the potential of using lipid membranes to influence the self-assembly of Janus particles.
authors: Department of Chemistry, Indiana University, Bloomington, IN 47405, USA. yy33@indiana.edu.
authors: Mariah
authors: M
authors: Chambers
authors: Department of Chemistry, Columbia University, 3000 Broadway, New York, NY 10027, USA. ac2822@columbia.edu.
authors: Stewart Anthony
authors: SA
authors: Mallory
authors: Department of Chemistry, Indiana University, Bloomington, IN 47405, USA. yy33@indiana.edu.
authors: Heather
authors: H
authors: Malone
authors: Department of Chemistry, Indiana University, Bloomington, IN 47405, USA. yy33@indiana.edu.
authors: Yuan
authors: Y
authors: Gao
authors: Department of Bioenergy and Defense Technology, Sandia National Laboratories, Albuquerque, NM 87123, USA.
authors: Stephen M
authors: http://orcid.org/0000-0003-4464-8418
authors: SM
authors: Anthony
authors: Department of Chemistry, Indiana University, Bloomington, IN 47405, USA. yy33@indiana.edu.
authors: Yi
authors: Y
authors: Yi
authors: Department of Chemistry, Columbia University, 3000 Broadway, New York, NY 10027, USA. ac2822@columbia.edu.
authors: Angelo
authors: A
authors: Cacciuto
authors: Department of Chemistry, Indiana University, Bloomington, IN 47405, USA. yy33@indiana.edu.
authors: Yan
authors: Y
authors: Yu
mesh_terms: D008055:Lipids / Q000737:chemistry*; D056004:Molecular Dynamics Simulation; D053835:Unilamellar Liposomes / Q000737:chemistry*
chemical_list: D008055:Lipids; D053835:Unilamellar Liposomes