title: Fluorescence based fiber optic and planar waveguide biosensors. A review.
abstract: The application of optical biosensors, specifically those that use optical fibers and planar waveguides, has escalated throughout the years in many fields, including environmental analysis, food safety and clinical diagnosis. Fluorescence is, without doubt, the most popular transducer signal used in these devices because of its higher selectivity and sensitivity, but most of all due to its wide versatility. This paper focuses on the working principles and configurations of fluorescence-based fiber optic and planar waveguide biosensors and will review biological recognition elements, sensing schemes, as well as some major and recent applications, published in the last ten years. The main goal is to provide the reader a general overview of a field that requires the joint collaboration of researchers of many different areas, including chemistry, physics, biology, engineering, and material science.
authors: Department of Analytical Chemistry, Faculty of Chemistry, Complutense University, 28040 Madrid, Spain.
authors: Elena
authors: E
authors: Benito-Peña
authors: Department of Analytical Chemistry, Faculty of Chemistry, University of La Habana, 10400 La Habana, Cuba.
authors: Mayra Granda
authors: MG
authors: Valdés
authors: Department of Analytical Chemistry, Faculty of Chemistry, Complutense University, 28040 Madrid, Spain.
authors: Bettina
authors: B
authors: Glahn-Martínez
authors: Department of Analytical Chemistry, Faculty of Chemistry, Complutense University, 28040 Madrid, Spain. Electronic address: mcmbondi@quim.ucm.es.
authors: Maria C
authors: MC
authors: Moreno-Bondi
mesh_terms: D015374:Biosensing Techniques; D005336:Fiber Optic Technology; D005453:Fluorescence
keywords: Antibodies; Biorecognition elements; Enzymes; Fiber optic and planar waveguide biosensors; Fluorescence techniques; Genetically engineered and biomimetic synthetic receptors; Nucleic acids; Optical sensing