title: Subjective memory complaints are associated with poorer cognitive performance in adults with HIV.
abstract: With successful antiretroviral therapy in the US, HIV-positive adults now routinely survive into old age. However, increased life expectancy with HIV introduces the added complication of age-related cognitive decline. Aging with HIV has been associated with poorer cognitive outcomes compared to HIV-negative adults. While up to 50% of older HIV-positive adults will develop some degree of cognitive impairment over their lifetime, cognitive symptoms are often not consistently monitored, until those symptoms are significant enough to impair daily life. In this study we found that subjective memory complaint (SMC) ratings correlated with measurable memory performance impairments in HIV-positive adults, but not HIV-negative adults. As the HIV-positive population ages, structured subjective cognitive assessment may be beneficial to identify the early signs of cognitive impairment, and subsequently allow for earlier interventions to maintain cognitive performance as these adults continue to survive into old age.
authors: a Department of Psychiatry , Vanderbilt Center for Cognitive Medicine , Nashville , TN , USA.
authors: Asante
authors: A
authors: Kamkwalala
authors: b Department of Medicine, Division of Infectious Diseases , Vanderbilt University Medical Center , Nashville , TN , USA.
authors: Todd
authors: T
authors: Hulgan
authors: a Department of Psychiatry , Vanderbilt Center for Cognitive Medicine , Nashville , TN , USA.|c Veterans Affairs Tennessee Valley Healthcare System Geriatric Research, Education, and Clinical Center (VA TVHS GRECC) , Nashville , TN , USA.
authors: Paul
authors: P
authors: Newhouse
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000523:psychology*; D003071:Cognition; D003072:Cognition Disorders / Q000209:etiology*; D005260:Female; D015658:HIV Infections / Q000523:psychology*; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000209:etiology*; D008570:Memory, Short-Term; D008875:Middle Aged; D009483:Neuropsychological Tests; D013647:Task Performance and Analysis; D055815:Young Adult
keywords: HIV-1; aging; cognition; memory; subjective memory impairment