title: Current management of aneurysmal bone cysts.
abstract: Aneurysmal bone cysts (ABCs) are benign bone lesions arising predominantly in the pediatric population that can cause local pain, swelling, and pathologic fracture. Primary lesions, which constitute roughly two thirds of all ABCs, are thought to be neoplastic in nature, with one third of ABCs arising secondary to other tumors. Diagnosis is made with various imaging modalities, which exhibit characteristic features such as "fluid-fluid levels," although biopsy is critical, as telangiectatic osteosarcoma cannot be excluded based on imaging alone. Currently, the standard of care and most widely employed treatment is intralesional curettage. However, tumor recurrence with curettage alone is common and has driven some to propose a multitude of adjuvants with varying efficacy and risk profiles. Historically, therapies such as en bloc resection or radiation therapy were utilized as an alternative to decrease the recurrence rate, but these therapies imposed high morbidity. As a result, modern techniques now seek to simultaneously reduce morbidity and recurrence, the pursuit of which has produced preliminary study into minimally invasive percutaneous treatments and medical management.
authors: Department of Orthopaedic Surgery, University of California, Los Angeles, 1250 16th St, Suite 2100, Santa Monica, CA, 90404, USA.
authors: Howard Y
authors: HY
authors: Park
authors: Department of Pediatrics, Hematology-Oncology, University of California, Los Angeles, Los Angeles, USA.
authors: Sara K
authors: SK
authors: Yang
authors: Department of Orthopaedic Surgery, University of California, Los Angeles, 1250 16th St, Suite 2100, Santa Monica, CA, 90404, USA.
authors: William L
authors: WL
authors: Sheppard
authors: Department of Orthopaedic Surgery, University of California, Los Angeles, 1250 16th St, Suite 2100, Santa Monica, CA, 90404, USA.
authors: Vishal
authors: V
authors: Hegde
authors: Department of Orthopaedic Surgery, University of California, Los Angeles, 1250 16th St, Suite 2100, Santa Monica, CA, 90404, USA.
authors: Stephen D
authors: SD
authors: Zoller
authors: Department of Pathology & Laboratory Medicine, University of California, Los Angeles, Los Angeles, USA.
authors: Scott D
authors: SD
authors: Nelson
authors: Department of Pediatrics, Hematology-Oncology, University of California, Los Angeles, Los Angeles, USA.
authors: Noah
authors: N
authors: Federman
authors: Department of Orthopaedic Surgery, University of California, Los Angeles, 1250 16th St, Suite 2100, Santa Monica, CA, 90404, USA. nbernthal@mednet.ucla.edu.
authors: Nicholas M
authors: NM
authors: Bernthal
keywords: Aneurysmal bone cyst; Benign bone tumor; Pediatric tumor