title: Divergent evolution of life span associated with mitochondrial DNA evolution.
abstract: Mitochondria play a key role in ageing. The pursuit of genes that regulate variation in life span and ageing have shown that several nuclear-encoded mitochondrial genes are important. However, the role of mitochondrial encoded genes (mtDNA) is more controversial and our appreciation of the role of mtDNA for the evolution of life span is limited. We use replicated lines of seed beetles that have been artificially selected for long or short life for >190 generations, now showing dramatic phenotypic differences, to test for a possible role of mtDNA in the divergent evolution of ageing and life span. We show that these divergent selection regimes led to the evolution of significantly different mtDNA haplotype frequencies. Selection for a long life and late reproduction generated positive selection for one specific haplotype, which was fixed in most such lines. In contrast, selection for reproduction early in life led to both positive selection as well as negative frequency-dependent selection on two different haplotypes, which were both present in all such lines. Our findings suggest that the evolution of life span was in part mediated by mtDNA, providing support for the emerging general tenet that adaptive evolution of life-history syndromes may involve mtDNA.
authors: Institute of Zoology, Faculty of Biology, University of Belgrade, Studentski trg 16, 11000, Belgrade, Serbia.|Department of Evolutionary Biology, Institute for Biological Research "Siniša Stanković, University of Belgrade, Despota Stefana Boulevard 142, 11060, Belgrade, Serbia.
authors: Biljana
authors: B
authors: Stojković
authors: Animal Ecology, Department of Ecology and Genetics, Evolutionary Biology Centre, Uppsala University, Norbyvägen 18D, SE-752 36, Uppsala, Sweden.
authors: Ahmed
authors: A
authors: Sayadi
authors: Department of Evolutionary Biology, Institute for Biological Research "Siniša Stanković, University of Belgrade, Despota Stefana Boulevard 142, 11060, Belgrade, Serbia.
authors: Mirko
authors: M
authors: Đorđević
authors: Department of Plant Pests, Institute for Plant Protection and Environment, Banatska 33, 11080, Zemun, Serbia.
authors: Jelena
authors: J
authors: Jović
authors: Animal Ecology, Department of Ecology and Genetics, Evolutionary Biology Centre, Uppsala University, Norbyvägen 18D, SE-752 36, Uppsala, Sweden.
authors: Uroš
authors: U
authors: Savković
authors: Department of Evolutionary Biology, Institute for Biological Research "Siniša Stanković, University of Belgrade, Despota Stefana Boulevard 142, 11060, Belgrade, Serbia.
authors: Göran
authors: G
authors: Arnqvist
mesh_terms: D000375:Aging; D000818:Animals; D002467:Cell Nucleus; D001517:Coleoptera / Q000235:genetics*; D004272:DNA, Mitochondrial / Q000235:genetics*; D019143:Evolution, Molecular; D050259:Genes, Mitochondrial; D006239:Haplotypes; D008136:Longevity; D018895:Microsatellite Repeats
chemical_list: D004272:DNA, Mitochondrial
keywords: Acanthoscelides obtectus; Bruchinae; artificial selection; coadaptation; mitochondria; mtDNA; negative frequency dependent selection; senescence