title: Surveillance for tuberculosis in a rural community in The Philippines.
abstract: Estimates of the tuberculosis (TB) burden in the Philippines are largely dependent on prevalence surveys.
  
  
  
  To conduct a prospective community-based survey to generate epidemiological data on TB among patients seeking care in public health centres in a rural municipality in the Philippines.
  
  
  
  Prospective surveillance and follow-up of presumptive TB cases from May 2013 to July 2015.
  
  
  
  Of 1622 participants with presumptive TB, 468 (28.8%) (95%CI 26.6-31.1) were diagnosed with TB. The annual TB case notification rate in San Juan was 212 (95%CI 184-242) per 100 000 population. There were nine TB-attributable deaths during the study period. Only 8.8% (95%CI 6.2-11.32) of the cases were children aged <15 years; 274 (58.5%) cases were bacteriologically confirmed. Of 210 isolates tested for antimicrobial resistance, 49 (23.3%, 95%CI 17.58-29.02) were resistant. Resistance to isoniazid (INH) was common (n = 33, 15.7%); multidrug-resistant TB was 1.9%.
  
  
  
  TB remains an important health problem in the Philippines. We identified low case detection of TB in children and high INH resistance rates in this rural community.
authors: National Institutes of Health, University of the Philippines Manila, Manila, The Philippines.
authors: A L
authors: AL
authors: Lopez
authors: National Institutes of Health, University of the Philippines Manila, Manila, The Philippines.
authors: J G
authors: JG
authors: Aldaba
authors: Research Institute for Tropical Medicine, Manila, The Philippines.
authors: C G
authors: CG
authors: Ama
authors: National Institutes of Health, University of the Philippines Manila, Manila, The Philippines.
authors: P G
authors: PG
authors: Sylim
authors: National Institutes of Health, University of the Philippines Manila, Manila, The Philippines.
authors: X D
authors: XD
authors: Geraldino
authors: National Teacher Training Center for the Health Professions, University of the Philippines Manila, Manila, The Philippines.
authors: J N
authors: JN
authors: Sarol
authors: National Institutes of Health, University of the Philippines Manila, Manila, The Philippines.
authors: A M
authors: AM
authors: Salonga
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000995:Antitubercular Agents / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007538:Isoniazid / Q000627:therapeutic use; D007612:Kanamycin / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010679:Philippines / Q000453:epidemiology; D011159:Population Surveillance; D015995:Prevalence; D011446:Prospective Studies; D011634:Public Health; D012293:Rifampin / Q000627:therapeutic use; D012424:Rural Population; D013307:Streptomycin / Q000627:therapeutic use; D016896:Treatment Outcome; D014376:Tuberculosis / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D018088:Tuberculosis, Multidrug-Resistant / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D055815:Young Adult
chemical_list: D000995:Antitubercular Agents; D007612:Kanamycin; D007538:Isoniazid; D012293:Rifampin; D013307:Streptomycin