title: Activation of Tryptophan and Phenylalanine Catabolism in the Remission Phase of Allergic Contact Dermatitis: A Pilot Study.
abstract: BACKGROUND
  Allergic contact dermatitis (ACD) is an inflammatory skin disease caused by repeated skin exposure to contact allergens. The severity and duration of this disease are associated with many different factors. Some of these factors may represent markers for monitoring disease activity and the individual response to an intervention.
  
  
  METHODS
  We used a targeted metabolomics approach to find such factors in the serum of individuals with ACD. Metabolomics profiles were examined and compared in the acute phase of the disease and also in the absence of disease activity.
  
  
  RESULTS
  Our study identified a significant remission phase of ACD-associated systemic biochemical shifts in 2 metabolic pathways: tryptophan-kynurenine and phenylalanine-tyrosine.
  
  
  CONCLUSIONS
  Although the responsible mechanisms are unclear, these results suggest that the remission phase of ACD is linked to tryptophan metabolism via kynurenine and phenylalanine-tyrosine pathways. However, further replication studies with a larger number of subjects and their subgroups are necessary to validate our results. These studies may provide a new perspective with which to understand the mechanism of and find potential biomarkers of ACD, as well as a new reference for personalized treatment.
authors: Department of Immunology, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania.
authors: Auksė
authors: A
authors: Zinkevičienė
authors: Denis
authors: D
authors: Kainov
authors: Irutė
authors: I
authors: Girkontaitė
authors: Eglė
authors: E
authors: Lastauskienė
authors: Violeta
authors: V
authors: Kvedarienė
authors: Yu
authors: Y
authors: Fu
authors: Simon
authors: S
authors: Anders
authors: Vidya
authors: V
authors: Velagapudi
mesh_terms: D000328:Adult; D000485:Allergens / Q000276:immunology; D016022:Case-Control Studies; D017449:Dermatitis, Allergic Contact / Q000188:drug therapy / Q000276:immunology / Q000378:metabolism*; D004198:Disease Susceptibility; D005260:Female; D006801:Humans; D008297:Male; D055442:Metabolome; D055432:Metabolomics / Q000379:methods; D008875:Middle Aged; D010649:Phenylalanine / Q000378:metabolism*; D010865:Pilot Projects; D014364:Tryptophan / Q000378:metabolism*; D055815:Young Adult
chemical_list: D000485:Allergens; D010649:Phenylalanine; D014364:Tryptophan