title: Simple and Specific Grafting of Antibacterial Peptides on Silicone Catheters.
abstract: To fight against nosocomial infection initiated by colonization of medical devices, a strategy enabling the direct and fast functionalization of silicone surfaces is proposed. This strategy proceeds in a site-specific way using original hybrid silylated antibacterial peptides. This safe and up-scalable method guarantees a covalent and robust immobilization with the correct orientation of the bioactive moiety. Importantly it also avoids multi-step chemical modifications of the surface or multi-layer polymer coatings. As proof of concept, antibacterial silicone catheter has been prepared whose immediate and long term efficiency is superior by comparison to similar silver-embedded materials.
authors: Institut des Biomolécules Max Mousseron (IBMM), UMR5247 CNRS, ENSCM, Université de Montpellier, 34000, Montpellier, France.
authors: Coline
authors: C
authors: Pinese
authors: Institut des Biomolécules Max Mousseron (IBMM), UMR5247 CNRS, ENSCM, Université de Montpellier, 34000, Montpellier, France.
authors: Said
authors: S
authors: Jebors
authors: Institut des Biomolécules Max Mousseron (IBMM), UMR5247 CNRS, ENSCM, Université de Montpellier, 34000, Montpellier, France.
authors: Cécile
authors: C
authors: Echalier
authors: HydroSciences Montpellier, UMR5569 CNRS, IRD, Université de Montpellier, 34000, Montpellier, France.
authors: Patricia
authors: P
authors: Licznar-Fajardo
authors: Institut des Biomolécules Max Mousseron (IBMM), UMR5247 CNRS, ENSCM, Université de Montpellier, 34000, Montpellier, France.
authors: Xavier
authors: X
authors: Garric
authors: Laboratoire de Réactivité de Surface (LRS), UMR 7197 Sorbonne Universités, UPMC Université de Paris 06, 75000, Paris, France.
authors: Vincent
authors: V
authors: Humblot
authors: Laboratoire de Réactivité de Surface (LRS), UMR 7197 Sorbonne Universités, UPMC Université de Paris 06, 75000, Paris, France.
authors: Christophe
authors: C
authors: Calers
authors: Institut des Biomolécules Max Mousseron (IBMM), UMR5247 CNRS, ENSCM, Université de Montpellier, 34000, Montpellier, France.
authors: Jean
authors: J
authors: Martinez
authors: Institut Charles Gerhardt (ICG), UMR5253 CNRS, ENSCM, Université de Montpellier, 34000, Montpellier, France.
authors: Ahmad
authors: A
authors: Mehdi
authors: Institut des Biomolécules Max Mousseron (IBMM), UMR5247 CNRS, ENSCM, Université de Montpellier, 34000, Montpellier, France.
authors: Gilles
authors: G
authors: Subra
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D001422:Bacterial Adhesion / Q000187:drug effects; D018441:Biofilms / Q000187:drug effects; D020099:Coated Materials, Biocompatible / Q000737:chemistry / Q000494:pharmacology; D003428:Cross Infection / Q000188:drug therapy; D008826:Microbial Sensitivity Tests / Q000379:methods; D010455:Peptides / Q000737:chemistry* / Q000494:pharmacology; D011108:Polymers / Q000737:chemistry; D012828:Silicones / Q000737:chemistry*; D012834:Silver / Q000737:chemistry; D013499:Surface Properties / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D020099:Coated Materials, Biocompatible; D010455:Peptides; D011108:Polymers; D012828:Silicones; D012834:Silver
keywords: antibacterial silicone; hybrid materials; silylated peptides; surface modification