title: Examining the protective effects of acetyl l-carnitine on cisplatin-induced uterine tube toxicity.
abstract: The aim of this study was to investigate the effects of cisplatin and the protective role of acetyl l-carnitine against uterine tube toxicity. Twenty-four female Wistar albino rats were divided into four groups: control group was injected with saline (control); group 2 was injected with acetyl l-carnitine; group 3 was injected with cisplatin; and group 4 was pre-treated with acetyl l-carnitine before cisplatin intraperitoneal injection. According to our results, a significant weight loss was observed in rats from group 3. The thickness of the wall and epithelium of uterine tube were decreased in group 3 rats. We elaborate the protein expression of caspase in epithelium and stroma by IHC. We found that the expression of caspase and the number of TUNEL-positive cells were increased in group 3 rats compared to the other groups. In our study, we showed the protective role of acetyl l-carnitine against uterine tube toxicity caused by cisplatin.
authors: a Faculty of Medicine, Department of Histology and Embryology , Gazi University , Ankara , Turkey.
authors: Gulistan Sanem
authors: GS
authors: Saribas
authors: a Faculty of Medicine, Department of Histology and Embryology , Gazi University , Ankara , Turkey.
authors: Deniz
authors: D
authors: Erdogan
authors: a Faculty of Medicine, Department of Histology and Embryology , Gazi University , Ankara , Turkey.
authors: Guleser
authors: G
authors: Goktas
authors: a Faculty of Medicine, Department of Histology and Embryology , Gazi University , Ankara , Turkey.
authors: Seda Nur
authors: SN
authors: Akyol
authors: b Faculty of Medicine, Department of Pediatrics, Neonatology Unit , Gazi University , Ankara , Turkey.
authors: Ibrahim Murat
authors: IM
authors: Hirfanoglu
authors: c School of Vocational Health Services, Department of Histology and Embryology , Celal Bayar University , Manisa , Turkey.
authors: Seren Gulsen
authors: SG
authors: Gurgen
authors: a Faculty of Medicine, Department of Histology and Embryology , Gazi University , Ankara , Turkey.
authors: Neslihan
authors: N
authors: Coskun
authors: a Faculty of Medicine, Department of Histology and Embryology , Gazi University , Ankara , Turkey.
authors: Candan
authors: C
authors: Ozogul
mesh_terms: D000108:Acetylcarnitine / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity*; D002945:Cisplatin / Q000633:toxicity*; D005187:Fallopian Tubes / Q000187:drug effects* / Q000473:pathology; D005260:Female; D020011:Protective Agents / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D014803:Vitamin B Complex / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D020011:Protective Agents; D014803:Vitamin B Complex; D000108:Acetylcarnitine; D002945:Cisplatin
keywords: Cisplatin; acetyl l-carnitine; apoptosis; uterine tube