title: Ir-Catalyzed C-H Amidation of Aldehydes with Stoichiometric/Catalytic Directing Group.
abstract: Ir-catalyzed sp2C-H amidation of aldehydes with various anilines as stoichiometric or catalytic directing groups was accomplished. A wide range of substrates were selectively amidated in good to excellent yields with broad functional group tolerance. The iridacycle complexes were isolated, characterized, and proved as key intermediates. Kinetic studies and Hammett plots provided detailed understandings of this amidation. According to the mechanism, the electron-rich ArSO2N3was proved effective for intermolecular sp3C-H amidation.
authors: Beijing National Laboratory of Molecular Sciences (BNLMS) and Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering and Green Chemistry Center, Peking University, Beijing, 100871, P.R. China.
authors: Yun-Fei
authors: YF
authors: Zhang
authors: Beijing National Laboratory of Molecular Sciences (BNLMS) and Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering and Green Chemistry Center, Peking University, Beijing, 100871, P.R. China.
authors: Bin
authors: B
authors: Wu
authors: Beijing National Laboratory of Molecular Sciences (BNLMS) and Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering and Green Chemistry Center, Peking University, Beijing, 100871, P.R. China.|State Key Laboratory of Organometallic Chemistry, Chinese Academy of Sciences, Shanghai, 200032, P. R. China.
authors: Zhang-Jie
authors: ZJ
authors: Shi
keywords: C−H amidation; aldehydes; imines; iridium; transient directing group