title: Catechins and Its Role in Chronic Diseases.
abstract: The mechanisms of action of polyphenols have attracted much attention. Catechins are generally known as tea polyphenols. Researchers have extensively investigated the molecular mechanisms of these substances, especially (-)-epigallocatechin gallate of green tea catechin, and have provided new insights in the prevention and therapy for chronic diseases. This chapter summarizes catechins and their effects on chronic diseases, including metabolic syndromes, cardiovascular diseases, neurodegenerative diseases, and cancer, focusing on the effects of green tea catechins.
authors: Department of Informative Clinical Medicine, Graduate School of Medicine, Gifu University, 1-1 Yanagido, Gifu, 501-1194, Japan. ys2443@gifu-u.ac.jp.|Department of Gastroenterology, Graduate School of Medicine, Gifu University, Gifu, 501-1194, Japan. ys2443@gifu-u.ac.jp.
authors: Yohei
authors: Y
authors: Shirakami
authors: Department of Gastroenterology, Graduate School of Medicine, Gifu University, Gifu, 501-1194, Japan.
authors: Hiroyasu
authors: H
authors: Sakai
authors: Department of Gastroenterology, Graduate School of Medicine, Gifu University, Gifu, 501-1194, Japan.
authors: Takahiro
authors: T
authors: Kochi
authors: Department of Informative Clinical Medicine, Graduate School of Medicine, Gifu University, 1-1 Yanagido, Gifu, 501-1194, Japan.
authors: Mitsuru
authors: M
authors: Seishima
authors: Department of Gastroenterology, Graduate School of Medicine, Gifu University, Gifu, 501-1194, Japan.
authors: Masahito
authors: M
authors: Shimizu
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D002317:Cardiovascular Agents / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D002392:Catechin / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D002908:Chronic Disease / Q000188:drug therapy*; D004195:Disease Models, Animal; D055808:Drug Discovery / Q000379:methods*; D006801:Humans; D015394:Molecular Structure; D018696:Neuroprotective Agents / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D010946:Plants, Medicinal; D015398:Signal Transduction / Q000187:drug effects; D013329:Structure-Activity Relationship; D013662:Tea / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D002317:Cardiovascular Agents; D018696:Neuroprotective Agents; D010936:Plant Extracts; D013662:Tea; D002392:Catechin
keywords: Cancer; Cardiovascular disease; Catechin; Chemoprevention; Green tea; Metabolic syndrome; Neurodegenerative disease; Obesity