title: Miktoarm star copolymers from D-(-)-salicin core aggregated into dandelion-like structures as anticancer drug delivery systems: synthesis, self-assembly and drug release.
abstract: The β-glucoside-based heterofunctional initiator was used in the synthesis of well-defined eight-armed miktopolymers by sequential ring opening polymerization (ROP) of ε-caprolactone (CL) and atom transfer radical (co)polymerization (ATRP) of methyl methacrylate (MMA) and/or tert-butyl methacrylate (tBMA). Consequently, methacrylic acid (MAA) repeating units were introduced via selective cleavage of pendant tert-butyl protecting groups. Both the amphiphilic copolymers and miktoarm copolymers were self-assembled at 37°C and pH 7.4. The aggregates of miktoarm polymers were larger than that formed by polymethacrylate homoarm stars (≥250nm vs ≤200nm). The critical aggregation concentrations (CAC) of (mikto)stars were relatively low (0.006-0.411mg/mL) and decreased with the increase in MAA fraction content. Both MAA-based mikto- and homoarmed (co)polymers with shorter arms exhibited lower doxorubicin (DOX) loading capacity, whereas camptothecin (CPT) was encapsulated preferably by miktostars. The kinetic profiles of drug release showed that the rate of release was higher at acidic environment (pH 5.0) than in neutral pH. In the most cases the studied miktopolymer systems demonstrated the well-controlled delivery of the model anticancer drugs, which can be adjusted by structural parameters of polymeric carriers.
authors: Department of Physical Chemistry and Technology of Polymers, Faculty of Chemistry, Silesian University of Technology, M. Strzody 9 Street, 44-100 Gliwice, Poland.
authors: Anna
authors: A
authors: Mielańczyk
authors: Department of Physical Chemistry and Technology of Polymers, Faculty of Chemistry, Silesian University of Technology, M. Strzody 9 Street, 44-100 Gliwice, Poland.
authors: Justyna
authors: J
authors: Odrobińska
authors: Department of Physical Chemistry and Technology of Polymers, Faculty of Chemistry, Silesian University of Technology, M. Strzody 9 Street, 44-100 Gliwice, Poland.
authors: Sebastian
authors: S
authors: Grządka
authors: Department of Histology and Embryology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia in Katowice, Jordana 19 Street, 41-808 Zabrze, Poland.
authors: Łukasz
authors: Ł
authors: Mielańczyk
authors: Department of Physical Chemistry and Technology of Polymers, Faculty of Chemistry, Silesian University of Technology, M. Strzody 9 Street, 44-100 Gliwice, Poland. Electronic address: dorota.neugebauer@polsl.pl.
authors: Dorota
authors: D
authors: Neugebauer
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry*; D001592:Benzyl Alcohols / Q000737:chemistry*; D002166:Camptothecin / Q000737:chemistry; D002208:Caproates / Q000737:chemistry; D003692:Delayed-Action Preparations / Q000737:chemistry; D004317:Doxorubicin / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods; D065546:Drug Liberation; D005960:Glucosides / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D007783:Lactones / Q000737:chemistry; D008689:Methacrylates / Q000737:chemistry; D058105:Polymerization; D011108:Polymers / Q000737:chemistry*; D011109:Polymethacrylic Acids / Q000737:chemistry; D031205:Taraxacum / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D001592:Benzyl Alcohols; D002208:Caproates; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D005960:Glucosides; D007783:Lactones; D008689:Methacrylates; D011108:Polymers; D011109:Polymethacrylic Acids; C008384:methacrylic acid; C030613:polymethacrylic acid; C005696:salicin; C121056:caprolactone; D004317:Doxorubicin; D002166:Camptothecin
keywords: Camptothecin; Doxorubicin; Drug delivery; Drug-loading; Miktoarm star polymers