title: Evaluating the morphological changes of intracranial arteries and whole-brain perfusion in undetermined isolated vertigo.
abstract: OBJECTIVE
  To determine the morphological changes of intracranial arteries and whole-brain perfusion in undetermined isolated vertigo (UIV) patients using 320-detector row computed tomography (CT).
  
  
  METHODS
  A total of 150 patients who underwent CT angiography (CTA) and CT perfusion (CTP) imaging were divided into UIV group and benign paroxysmal positional vertigo (BPPV) group. Sixty individuals with sex- and age-matched without vertigo and cerebral diseases served as the control. The morphological changes of intracranial arteries, perfusion parameters and vascular risk factors (VRFs) were analyzed, calculated and compared.
  
  
  RESULTS
  In UIV patients, hypertension (HT), hyperlipidemia and number of VRFs≥3 occurred more commonly (P<0.0125, respectively). The incidence of vertebral artery dominance (VAD), vertebral artery stenosis (VAS) and basilar artery curvature (BAC) were significantly higher (P<0.0125, respectively). HT was an independent risk predictor of non-VAD (OR: 5.411, 95%CI: 1.401; 20.900, P=0.014). HT and VAD associated with BAC served as risk predictors (OR: 4.081, 95%CI: 1.056;15.775, P=0.041 and OR: 6.284, 95%CI: 1.848; 21.365, P=0.003, respectively). The absolute difference in relative values of CTP parameters from cerebellum and brainstem were significantly different (P<0.05), and hypoperfusion was found in the territories of the non-VAD side and the BAC cohort (P<0.05, respectively).
  
  
  CONCLUSIONS
  On the basis of multiple VRFs, morphological changes of vertebrobasilar artery (VBA) and the unilateral hypoperfusion of the cerebellum and brainstem, that acts as a herald for IV occurrence, which should be paid cautious attention to UIV patients.
authors: Department of Neurology, The First Affiliated Hospital, Jinan University, Guangzhou 510632, PR China.
authors: Wenxian
authors: W
authors: Li
authors: Medical Imaging Center, The First Affiliated Hospital, Jinan University, Guangzhou, Guangdong 510632, PR China.
authors: Youzhen
authors: Y
authors: Feng
authors: Department of Neurology, The First Affiliated Hospital, Jinan University, Guangzhou 510632, PR China.
authors: Weibiao
authors: W
authors: Lu
authors: Department of Neurology, The First Affiliated Hospital, Jinan University, Guangzhou 510632, PR China.
authors: Xie
authors: X
authors: Xie
authors: Department of Neurology, The First Affiliated Hospital, Jinan University, Guangzhou 510632, PR China.
authors: Zhilin
authors: Z
authors: Xiong
authors: Department of Neurology, The First Affiliated Hospital, Jinan University, Guangzhou 510632, PR China.
authors: Zhen
authors: Z
authors: Jing
authors: Medical Imaging Center, The First Affiliated Hospital, Jinan University, Guangzhou, Guangdong 510632, PR China.
authors: Xiangran
authors: X
authors: Cai
authors: Department of Neurology, The First Affiliated Hospital, Jinan University, Guangzhou 510632, PR China. Electronic address: huanglian1306@126.com.
authors: Li'an
authors: L
authors: Huang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000503:physiopathology; D016022:Case-Control Studies; D002533:Cerebral Angiography; D002539:Cerebral Arterial Diseases / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology; D002536:Cerebral Arteries / Q000000981:diagnostic imaging* / Q000503:physiopathology; D002560:Cerebrovascular Circulation / Q000502:physiology; D003251:Constriction, Pathologic / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D055420:Perfusion Imaging; D011446:Prospective Studies; D012307:Risk Factors; D014057:Tomography, X-Ray Computed; D014717:Vertigo / Q000150:complications / Q000000981:diagnostic imaging* / Q000503:physiopathology
keywords: 320-detector row computed tomography; Cerebral perfusion; Morphological changes of intracranial arteries; Undetermined isolated vertigo; Vascular risk factors