title: Axonal Degeneration: RIPK1 Multitasking in ALS.
abstract: A recent study reports that microglia and oligodendrocytes promote motor neuron degeneration by inducing inflammation and necroptosis in a manner dependent on receptor-interacting kinase 1 (RIPK1). These findings could be significant for our understanding of the neurobiology and treatment of neurodegenerative diseases like amyotrophic lateral sclerosis.
authors: Departments of Pathology & Cell Biology, Columbia University Medical Center, 630 West 168(th) Street, New York, NY 10032, USA; The Center for Motor Neuron Biology and Disease, Columbia University Medical Center, 630 West 168(th) Street, New York, NY 10032, USA.
authors: Kristin
authors: K
authors: Politi
authors: Departments of Pathology & Cell Biology, Columbia University Medical Center, 630 West 168(th) Street, New York, NY 10032, USA; The Center for Motor Neuron Biology and Disease, Columbia University Medical Center, 630 West 168(th) Street, New York, NY 10032, USA; Department of Neurology, Columbia University Medical Center, 630 West 168(th) Street, New York, NY 10032, USA. Electronic address: sp30@columbia.edu.
authors: Serge
authors: S
authors: Przedborski
mesh_terms: D000690:Amyotrophic Lateral Sclerosis; D017209:Apoptosis; D006801:Humans; D007249:Inflammation; D019636:Neurodegenerative Diseases; D053422:Receptor-Interacting Protein Serine-Threonine Kinases
chemical_list: C506249:RIPK1 protein, human; D053422:Receptor-Interacting Protein Serine-Threonine Kinases