title: Clinical significance of serum omentin-1 levels in patients with pancreatic adenocarcinoma.
abstract: BACKGROUND
  Omentin is related with metabolic syndrome and obesity. Pancreatic adenocarcinoma (PA) is a lethal and obesity-linked malignancy. This study was conducted to investigate the serum levels of omentin in patients with PA and the relationship with tumor progression and known prognostic parameters.
  
  
  METHODS
  Serum samples were obtained from thirty-three patients on first admission before any treatment. Age, sex and body mass index (BMI) matched 30 healthy controls were included in the analysis. Both serum omentin levels were measured using enzyme-linked immunosorbent assay (ELISA).
  
  
  RESULTS
  The median age at diagnosis was 59 years (32-84 years). Twenty (61%) patients were men and the remaining were women. The most common metastatic site was liver in 23 patients with metastasis (n = 19, 83%). Thirty-nine percent of 23 metastatic patients who received palliative chemotherapy (CTx) were CTx-responsive. Median overall survival of the whole group was 41.3 ± 8.3 weeks [95% confidence interval (CI) = 25-58 weeks]. The baseline serum omentin levels were significantly higher in patients with PA than in the control group (p < 0.001). Serum omentin levels were significantly higher in patients with larger pathologic tumor size compared with smaller size (p = 0.03). Conversely, serum omentin concentration was found to have no prognostic role on survival (p = 0.54).
  
  
  CONCLUSIONS
  Serum levels of omentin may have a good diagnostic role in patients with PA.
authors: Department of Medical Oncology, Institute of Oncology, Istanbul University, Istanbul, Turkey.
authors: Senem
authors: S
authors: Karabulut
authors: Department of Medical Oncology, Istanbul Education and Research Hospital, Istanbul, Turkey.
authors: Cigdem Usul
authors: CU
authors: Afsar
authors: Clinic of General Surgery, Istanbul Bakırköy Dr. Sadi Konuk Education and Research Hospital, Istanbul, Turkey.
authors: Mehmet
authors: M
authors: Karabulut
authors: Clinic of General Surgery, Istanbul Bakırköy Dr. Sadi Konuk Education and Research Hospital, Istanbul, Turkey.
authors: Halil
authors: H
authors: Alis
authors: Clinic of General Surgery, Istanbul Bakırköy Dr. Sadi Konuk Education and Research Hospital, Istanbul, Turkey.
authors: Mehmet Abdussamet
authors: MA
authors: Bozkurt
authors: Department of Medical Oncology, Institute of Oncology, Istanbul University, Istanbul, Turkey.
authors: Fatma
authors: F
authors: Aydogan
authors: Department of Basic Oncology, Institute of Oncology, Istanbul University, Istanbul, Turkey.
authors: Murat
authors: M
authors: Serilmez
authors: Department of Medical Oncology, Institute of Oncology, Istanbul University, Istanbul, Turkey.
authors: Faruk
authors: F
authors: Tas
keywords: Diagnostic; Omentin; Pancreatic adenocancer; Serum