title: RAF Inhibitors, Fishing Bacterial Transporters Out of Metagenomes, and Yeast-Based, Industrial Scale Production of Isoprenoids.
abstract: Every month the editors of Cell Chemical Biology bring you highlights of the most recent chemical biology literature. Our October 2016 selection includes systematic structural, biochemical, and cellular characterization of B-RAF inhibitors; connecting bacterial transporters with their physiologically relevant ligands; and rewiring yeast metabolism for industrial scale production of isoprenoids.
authors: Milka
authors: M
authors: Kostic
mesh_terms: D000818:Animals; D001419:Bacteria / Q000235:genetics* / Q000378:metabolism; D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism; D015374:Biosensing Techniques; D002352:Carrier Proteins / Q000235:genetics* / Q000378:metabolism; D055808:Drug Discovery; D016680:Genome, Bacterial; D006801:Humans; D007218:Industrial Microbiology / Q000379:methods*; D060847:Metabolic Engineering / Q000379:methods; D054892:Metagenome; D047428:Protein Kinase Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D048493:Proto-Oncogene Proteins B-raf / Q000037:antagonists & inhibitors* / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000378:metabolism*; D013729:Terpenes / Q000378:metabolism*; D048490:raf Kinases / Q000037:antagonists & inhibitors / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; D002352:Carrier Proteins; D047428:Protein Kinase Inhibitors; D013729:Terpenes; D048493:Proto-Oncogene Proteins B-raf; D048490:raf Kinases