title: Hippo pathway deregulation: implications in the pathogenesis of haematological malignancies.
abstract: The Hippo pathway participates in the regulation of cell proliferation, differentiation and apoptosis. It is composed by a large array of proteins whose deregulation has been associated with pro-oncogenic and antioncogenic processes. The present review focuses on the Hippo pathway signalling network and discusses its dual role in oncogenesis, particularly in haematological malignancies.
authors: Department of Clinical Analysis, Toxicology and Food Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo-USP, Ribeirão Preto, São Paulo, Brazil.
authors: Maira da Costa
authors: MC
authors: Cacemiro
authors: Department of Clinical Analysis, Toxicology and Food Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo-USP, Ribeirão Preto, São Paulo, Brazil.
authors: Maria Gabriela
authors: MG
authors: Berzoti-Coelho
authors: Department of Clinical Analysis, Toxicology and Food Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo-USP, Ribeirão Preto, São Paulo, Brazil.
authors: Juçara Gastaldi
authors: JG
authors: Cominal
authors: Department of Clinical Analysis, Toxicology and Food Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo-USP, Ribeirão Preto, São Paulo, Brazil.
authors: Sandra Mara
authors: SM
authors: Burin
authors: Department of Clinical Analysis, Toxicology and Food Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo-USP, Ribeirão Preto, São Paulo, Brazil.
authors: Fabíola Attié de
authors: FA
authors: Castro
mesh_terms: D017209:Apoptosis / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology; D049109:Cell Proliferation / Q000502:physiology; D019337:Hematologic Neoplasms / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D000090683:Hippo Signaling Pathway; D006801:Humans; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D017346:Protein Serine-Threonine Kinases
keywords: APOPTOSIS; CANCER; CELL CYCLE REGULATION; HAEMATO-ONCOLOGY; ONCOGENES