title: Association of Vitamin D receptor Fok I polymorphism with the risk of prostate cancer: a meta-analysis.
abstract: Several previous studies have been reported to examine the association between Vitamin D receptor (VDR) gene Fok I polymorphism and susceptibility to prostate cancer (PCa), however the results remain inconclusive. To provide a relatively comprehensive account of the association, we searched PubMed, Embase, CNKI, and Wanfang for eligible studies and carry out this meta-analysis. A total of 27 case-control studies with 10,486 cases and 10,400 controls were included. In the overall analysis, Fok I polymorphism was not significantly associated with the susceptibility to PCa. Subgroup analyses showed that significantly association was existed in Caucasian population, the subgroup of population-based controls and the stratified group with advanced tumor.These results indicate that the VDR Fok I polymorphism might be capable of causing PCa susceptibility and could be a promising target to forecast the PCa risk for clinical practice. However further well-designed epidemiologic studies are needed to confirm this conclusion.
authors: Department of Urology, North China University of Science and Technology Affiliated Hospital, Tangshan 063000, China.
authors: Shaosan
authors: S
authors: Kang
authors: Department of Imaging, KaiLuan General Hosptial, Tangshan 063000, China.
authors: Yansheng
authors: Y
authors: Zhao
authors: Department of Urology, North China University of Science and Technology Affiliated Hospital, Tangshan 063000, China.
authors: Jian
authors: J
authors: Liu
authors: Department of Urology, North China University of Science and Technology Affiliated Hospital, Tangshan 063000, China.
authors: Lei
authors: L
authors: Wang
authors: Department of Urology, KaiLuan General Hospital, Tangshan 063000, China.
authors: Geng
authors: G
authors: Zhao
authors: Department of Urology, North China University of Science and Technology Affiliated Hospital, Tangshan 063000, China.
authors: Xi
authors: X
authors: Chen
authors: Department of Urology, North China University of Science and Technology Affiliated Hospital, Tangshan 063000, China.
authors: Anliang
authors: A
authors: Yao
authors: Department of Urology, North China University of Science and Technology Affiliated Hospital, Tangshan 063000, China.
authors: Liguo
authors: L
authors: Zhang
authors: Department of Urology, North China University of Science and Technology Affiliated Hospital, Tangshan 063000, China.
authors: Xiaojun
authors: X
authors: Zhang
authors: Department of Urology, North China University of Science and Technology Affiliated Hospital, Tangshan 063000, China.
authors: Xiaoqiang
authors: X
authors: Li
mesh_terms: D016022:Case-Control Studies; D015252:Deoxyribonucleases, Type II Site-Specific / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000378:metabolism; D018167:Receptors, Calcitriol / Q000378:metabolism*; D012307:Risk Factors
chemical_list: D018167:Receptors, Calcitriol; C579457:VDR protein, human; C035042:endodeoxyribonuclease FokI; D015252:Deoxyribonucleases, Type II Site-Specific
keywords: Fok I; Vitamin D receptor; meta-analysis; polymorphisms; prostate cancer