title: TaOx decorated perfluorocarbon nanodroplets as oxygen reservoirs to overcome tumor hypoxia and enhance cancer radiotherapy.
abstract: Cancer radiotherapy (RT) is a clinically used tumor treatment strategy applicable for a wide range of solid tumors. However, during RT treatment of tumors, only a small portion of applied ionizing irradiation energy is absorbed by the tumor, in which the largely hypoxic microenvironment also limits the anti-tumor efficacy of RT. In this work, we rationally fabricate polyethylene glycol (PEG) stabilized perfluorocarbon (PFC) nano-droplets decorated with TaOx nanoparticles (TaOx@PFC-PEG) as a multifunctional RT sensitizer. The obtained TaOx@PFC-PEG nanoparticles on one hand can absorb X-ray by TaOx to concentrate radiation energy within tumor cells, on the other hand after saturating PFC with oxygen will act as an oxygen reservoir to gradually release oxygen and improve tumor oxygenation. As the result, remarkably enhanced in vivo RT treatment is achieved with TaOx@PFC-PEG nanoparticles in our mouse tumor model experiments. Our work thus presents a new nanotechnology strategy to enhance RT-induced tumor treatment by simultaneously concentrating radiation energy within tumors and improving tumor oxygenation, using one multifunctional agent.
authors: Institute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University Suzhou, Jiangsu 215123, China.
authors: Guosheng
authors: G
authors: Song
authors: Department of Respiratory Diseases, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China.
authors: Chenghong
authors: C
authors: Ji
authors: Institute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University Suzhou, Jiangsu 215123, China.
authors: Chao
authors: C
authors: Liang
authors: Institute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University Suzhou, Jiangsu 215123, China.
authors: Xuejiao
authors: X
authors: Song
authors: School of Radiation Medicine and Protection & School for Radiological and Interdisciplinary Sciences (RAD-X) Medical College of Soochow University Suzhou, Jiangsu 215123, China.
authors: Xuan
authors: X
authors: Yi
authors: Institute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University Suzhou, Jiangsu 215123, China.
authors: Ziliang
authors: Z
authors: Dong
authors: School of Radiation Medicine and Protection & School for Radiological and Interdisciplinary Sciences (RAD-X) Medical College of Soochow University Suzhou, Jiangsu 215123, China.
authors: Kai
authors: K
authors: Yang
authors: Institute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University Suzhou, Jiangsu 215123, China. Electronic address: zliu@suda.edu.cn.
authors: Zhuang
authors: Z
authors: Liu
mesh_terms: D065966:Absorption, Physicochemical; D000818:Animals; D045744:Cell Line, Tumor; D005466:Fluorocarbons / Q000737:chemistry*; D051379:Mice; D008807:Mice, Inbred BALB C; D053769:Nanocapsules / Q000737:chemistry* / Q000648:ultrastructure; D009374:Neoplasms, Experimental / Q000473:pathology / Q000532:radiotherapy*; D010087:Oxides / Q000008:administration & dosage* / Q000737:chemistry; D010100:Oxygen / Q000008:administration & dosage*; D011836:Radiation Tolerance / Q000187:drug effects; D013635:Tantalum / Q000008:administration & dosage* / Q000737:chemistry; D016896:Treatment Outcome; D000072258:Tumor Hypoxia / Q000187:drug effects*
chemical_list: D005466:Fluorocarbons; D053769:Nanocapsules; D010087:Oxides; D013635:Tantalum; C078151:tantalum oxide; D010100:Oxygen
keywords: Oxygen reservoir; Perfluorocarbon; Radiotherapy; Tantalum oxide; Tumor hypoxia