title: Effects of Proton Pump Inhibitor Administration and Intake of a Combination of Yogurt and Galactooligosaccharides on Bone and Mineral Metabolism in Rats.
abstract: The aim of this study was to investigate the effects of proton pump inhibitor (PPI), the most potent acid-suppressing drug, administration and intake of a combination of yogurt and galactooligosaccharides (YG) on bone and mineral metabolism in adult rats. Twelve-week-old male Wistar rats were divided into three groups: a control group fed the control diet with vehicle administration, a PPI group fed the control diet with PPI administration and a YG + PPI group fed the YG diet with PPI administration. All of the groups received their respective experimental diets and daily subcutaneous injection of the vehicle or PPI for 12 weeks. The PPI group showed significantly lower bone mineral density (BMD) of the femur and the lumbar vertebrae and serum fibroblast growth factor 23 (FGF23) and significantly higher phosphorus absorption and serum 1,25-dihydroxyvitamin D (1,25(OH)2D) than the control group, although PPI did not affect calcium absorption. The PPI + YG group showed significantly higher BMD and serum FGF23 and significantly lower phosphorus absorption and serum 1,25(OH)2D than the PPI group. Furthermore, the PPI + YG group showed higher calcium absorption than the control group. These results suggest that although PPI administration did not affect calcium absorption, it adversely affected BMD and influenced phosphorus metabolism in adult rats. Furthermore, the YG diet beneficially affected BMD and attenuated the effects of PPI administration on phosphorus metabolism.
authors: Food Science Research Laboratories, Division of Research and Development, Meiji Co., Ltd., Odawara 250-0862, Japan. satoshi.takasugi@meiji.com.
authors: Satoshi
authors: S
authors: Takasugi
authors: Food Science Research Laboratories, Division of Research and Development, Meiji Co., Ltd., Odawara 250-0862, Japan. miho.shioyama@meiji.com.
authors: Miho
authors: M
authors: Shioyama
authors: Food Science Research Laboratories, Division of Research and Development, Meiji Co., Ltd., Odawara 250-0862, Japan. masami.kitade@meiji.com.
authors: Masami
authors: M
authors: Kitade
authors: Food Science Research Laboratories, Division of Research and Development, Meiji Co., Ltd., Odawara 250-0862, Japan. masashi.nagata@meiji.com.
authors: Masashi
authors: M
authors: Nagata
authors: Food Science Research Laboratories, Division of Research and Development, Meiji Co., Ltd., Odawara 250-0862, Japan. taketo.yamaji@meiji.com.
authors: Taketo
authors: T
authors: Yamaji
mesh_terms: D000818:Animals; D015519:Bone Density; D001842:Bone and Bones / Q000187:drug effects* / Q000378:metabolism; D002136:Calcium, Dietary / Q000097:blood* / Q000494:pharmacology; D004032:Diet; D005269:Femur / Q000187:drug effects / Q000378:metabolism; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000097:blood; D005690:Galactose; D008159:Lumbar Vertebrae / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008903:Minerals / Q000097:blood; D009844:Oligosaccharides / Q000494:pharmacology*; D009853:Omeprazole / Q000009:adverse effects; D010758:Phosphorus / Q000097:blood*; D054328:Proton Pump Inhibitors / Q000009:adverse effects*; D017208:Rats, Wistar; D014807:Vitamin D / Q000031:analogs & derivatives / Q000097:blood; D015014:Yogurt / Q000382:microbiology
chemical_list: D002136:Calcium, Dietary; D008903:Minerals; D009844:Oligosaccharides; D054328:Proton Pump Inhibitors; D014807:Vitamin D; D010758:Phosphorus; D005346:Fibroblast Growth Factors; C097949:1,25-dihydroxyvitamin D; D000089703:Fibroblast Growth Factor-23; D009853:Omeprazole; D005690:Galactose
keywords: FGF23; bone mineral density; calcitriol; omeprazole; phosphorus; proton pump inhibitor