title: Interaction of Serum Antibodies from Breast Cancer Patients with Synthetic Peptides.
abstract: The blood serum of tumor patients contains antibodies recognizing tumor-associated antigens and other molecular products of tumor growth. We studied the interaction of blood antibodies from breast cancer patients with synthetic peptides that were applied on the microchip surface. The serum from healthy volunteers and breast cancer patients was shown to contain antibodies that interact with various peptides. Statistically significant between-group differences were observed in the level of binding with 122 informative peptides (0.01% of the total number of peptides on a microchip). Analysis of antibodies that interact with the peptide panel holds much promise for the diagnostics of breast cancer.
authors: Russian-American Anti-Cancer Center, Altai State University, Barnaul, Russian Federation.
authors: S V
authors: SV
authors: Podlesnykh
authors: Russian-American Anti-Cancer Center, Altai State University, Barnaul, Russian Federation.
authors: E A
authors: EA
authors: Kolosova
authors: Russian-American Anti-Cancer Center, Altai State University, Barnaul, Russian Federation.
authors: D N
authors: DN
authors: Shcherbakov
authors: Russian-American Anti-Cancer Center, Altai State University, Barnaul, Russian Federation.
authors: A A
authors: AA
authors: Shaidurov
authors: Russian-American Anti-Cancer Center, Altai State University, Barnaul, Russian Federation.
authors: D S
authors: DS
authors: Anisimov
authors: Russian-American Anti-Cancer Center, Altai State University, Barnaul, Russian Federation.
authors: M A
authors: MA
authors: Ryazanov
authors: Center for Innovations in Medicine, Biodesign Institute, Arizona State University, Tempe, AZ, USA.
authors: S A
authors: SA
authors: Johnston
authors: Altai State Medical University, Barnaul, Russian Federation.
authors: Ya N
authors: YN
authors: Shoikhet
authors: Altai Branch of the N. N. Blokhin Russian Cancer Research Center, Barnaul, Russian Federation.
authors: V D
authors: VD
authors: Petrova
authors: Altai Branch of the N. N. Blokhin Russian Cancer Research Center, Barnaul, Russian Federation.
authors: A F
authors: AF
authors: Lazarev
authors: Russian-American Anti-Cancer Center, Altai State University, Barnaul, Russian Federation. andreichapoval@gmail.com.|Center for Innovations in Medicine, Biodesign Institute, Arizona State University, Tempe, AZ, USA. andreichapoval@gmail.com.
authors: A I
authors: AI
authors: Chapoval
mesh_terms: D000595:Amino Acid Sequence; D000912:Antibodies, Neoplasm / Q000097:blood*; D000915:Antibody Affinity; D000918:Antibody Specificity; D000951:Antigens, Neoplasm / Q000097:blood / Q000276:immunology; D001323:Autoantibodies / Q000097:blood*; D001943:Breast Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000276:immunology; D016022:Case-Control Studies; D000939:Epitopes / Q000737:chemistry / Q000276:immunology; D005260:Female; D006801:Humans; D019151:Peptide Library; D010455:Peptides / Q000138:chemical synthesis / Q000276:immunology*; D040081:Protein Array Analysis / Q000379:methods*; D011485:Protein Binding
chemical_list: D000912:Antibodies, Neoplasm; D000951:Antigens, Neoplasm; D001323:Autoantibodies; D000939:Epitopes; D019151:Peptide Library; D010455:Peptides
keywords: antibodies; breast cancer; epitopes; mimotopes; peptides microchips