title: Unusual presentation of neosporosis in a neonatal puppy from a litter of bulldogs.
abstract: METHODS
  A 17-day-old Bulldog puppy died soon after presentation for weakness and tachypnoea. Gross lesions included diffuse pulmonary oedema and a region of myocardial pallor that resembled an infarct. Inflammation was observed histopathologically in many organs, with numerous clusters of intracellular protozoa that stained positively using Neospora caninum immunohistochemistry. Myocarditis was severe and had associated necrosis of individual myocytes, but the tissue was not infarcted. The bitch had an antibody titre of 1 : 1600 for N. caninum. All six littermates were sold and reported to be healthy at 6 months of age.
  
  
  CONCLUSIONS
  Unusual aspects of this case include the occurrence of clinical disease in only 1 of 7 neonatal puppies, widespread dissemination of the organism in multiple tissues, and regional pallor associated with myocarditis that gave a false gross appearance of infarction. This report also adds Bulldogs to the list of dog breeds shown to be susceptible to clinical neosporosis.
authors: School of Animal & Veterinary Sciences, University of Adelaide, South Australia, Australia. milton.mcallister@adelaide.edu.au.
authors: M M
authors: MM
authors: McAllister
authors: School of Animal & Veterinary Sciences, University of Adelaide, South Australia, Australia.
authors: O
authors: O
authors: Funnell
authors: Faculty of Veterinary Science, University of Sydney, NSW, Australia.
authors: S L
authors: SL
authors: Donahoe
authors: Faculty of Veterinary Science, University of Sydney, NSW, Australia.
authors: J
authors: J
authors: Šlapeta
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D003048:Coccidiosis / Q000469:parasitology / Q000662:veterinary*; D004283:Dog Diseases / Q000469:parasitology*; D004285:Dogs; D005260:Female; D007249:Inflammation / Q000469:parasitology / Q000662:veterinary; D008297:Male; D009205:Myocarditis / Q000469:parasitology / Q000662:veterinary*; D018688:Neospora / Q000302:isolation & purification*; D011654:Pulmonary Edema / Q000469:parasitology / Q000662:veterinary*
keywords: 
  Neospora caninum
  ; congenital disease; dogs; multisystemic infection