title: Material Properties from Air Puff Corneal Deformation by Numerical Simulations on Model Corneas.
abstract: OBJECTIVE
  To validate a new method for reconstructing corneal biomechanical properties from air puff corneal deformation images using hydrogel polymer model corneas and porcine corneas.
  
  
  METHODS
  Air puff deformation imaging was performed on model eyes with artificial corneas made out of three different hydrogel materials with three different thicknesses and on porcine eyes, at constant intraocular pressure of 15 mmHg. The cornea air puff deformation was modeled using finite elements, and hyperelastic material parameters were determined through inverse modeling, minimizing the difference between the simulated and the measured central deformation amplitude and central-peripheral deformation ratio parameters. Uniaxial tensile tests were performed on the model cornea materials as well as on corneal strips, and the results were compared to stress-strain simulations assuming the reconstructed material parameters.
  
  
  RESULTS
  The measured and simulated spatial and temporal profiles of the air puff deformation tests were in good agreement (< 7% average discrepancy). The simulated stress-strain curves of the studied hydrogel corneal materials fitted well the experimental stress-strain curves from uniaxial extensiometry, particularly in the 0-0.4 range. Equivalent Young´s moduli of the reconstructed material properties from air-puff were 0.31, 0.58 and 0.48 MPa for the three polymer materials respectively which differed < 1% from those obtained from extensiometry. The simulations of the same material but different thickness resulted in similar reconstructed material properties. The air-puff reconstructed average equivalent Young´s modulus of the porcine corneas was 1.3 MPa, within 18% of that obtained from extensiometry.
  
  
  CONCLUSIONS
  Air puff corneal deformation imaging with inverse finite element modeling can retrieve material properties of model hydrogel polymer corneas and real corneas, which are in good correspondence with those obtained from uniaxial extensiometry, suggesting that this is a promising technique to retrieve quantitative corneal biomechanical properties.
authors: Instituto de Óptica "Daza de Valdés", Consejo Superior de Investigaciones Científicas, Madrid, Spain.
authors: Nandor
authors: http://orcid.org/0000-0001-7532-9589
authors: N
authors: Bekesi
authors: Instituto de Óptica "Daza de Valdés", Consejo Superior de Investigaciones Científicas, Madrid, Spain.
authors: Carlos
authors: C
authors: Dorronsoro
authors: Instituto de Óptica "Daza de Valdés", Consejo Superior de Investigaciones Científicas, Madrid, Spain.
authors: Andrés
authors: A
authors: de la Hoz
authors: Instituto de Óptica "Daza de Valdés", Consejo Superior de Investigaciones Científicas, Madrid, Spain.
authors: Susana
authors: S
authors: Marcos
mesh_terms: D000388:Air; D000818:Animals; D003315:Cornea / Q000502:physiology*; D020342:Finite Element Analysis; D007429:Intraocular Pressure; D008954:Models, Biological; D019047:Phantoms, Imaging; D013314:Stress, Mechanical; D013552:Swine; D013718:Tensile Strength; D014065:Tonometry, Ocular