title: The isoflavone fraction from soybean presents mRNA maturation inhibition activity.
abstract: Recent findings indicate that mRNA splicing inhibitors can be potential anticancer candidates. We have previously established a screening system which monitors mRNA processing in order to identify mRNA processing inhibitors. Among a number of dietary resources, isoflavone fractions showed an inhibitory effect of mRNA processing. These findings demonstrate that a variety of dietary sources have an impact on mRNA biogenesis.
authors: a Division of Integrated Life Sciences, Graduate School of Biostudies , Kyoto University , Kyoto , Japan.|b Department of Oral and Maxillofacial Surgery , Graduate School of Medical Sciences, Nagoya City University , Nagoya , Japan.
authors: Masashi
authors: M
authors: Kurata
authors: c Department of Food and Nutrition , Kyoto Women's University , Kyoto , Japan.
authors: Yuki
authors: Y
authors: Murata
authors: d Department of Living and Welfare , Kyoto Women's University , Kyoto , Japan.
authors: Keiko
authors: K
authors: Momma
authors: a Division of Integrated Life Sciences, Graduate School of Biostudies , Kyoto University , Kyoto , Japan.
authors: Intisar
authors: I
authors: Fouad Ali Mursi
authors: e Department of Bioscience , Fukui Prefectural University , Fukui , Japan.
authors: Masakazu
authors: M
authors: Takahashi
authors: a Division of Integrated Life Sciences, Graduate School of Biostudies , Kyoto University , Kyoto , Japan.
authors: Yusaku
authors: Y
authors: Miyamae
authors: a Division of Integrated Life Sciences, Graduate School of Biostudies , Kyoto University , Kyoto , Japan.
authors: Taiho
authors: T
authors: Kambe
authors: a Division of Integrated Life Sciences, Graduate School of Biostudies , Kyoto University , Kyoto , Japan.
authors: Masaya
authors: M
authors: Nagao
authors: c Department of Food and Nutrition , Kyoto Women's University , Kyoto , Japan.
authors: Hiroshi
authors: H
authors: Narita
authors: b Department of Oral and Maxillofacial Surgery , Graduate School of Medical Sciences, Nagoya City University , Nagoya , Japan.
authors: Yasuyuki
authors: Y
authors: Shibuya
authors: a Division of Integrated Life Sciences, Graduate School of Biostudies , Kyoto University , Kyoto , Japan.
authors: Seiji
authors: S
authors: Masuda
mesh_terms: D002460:Cell Line; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D006367:HeLa Cells / Q000187:drug effects; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007529:Isoflavones / Q000494:pharmacology*; D049410:Luciferases, Renilla / Q000235:genetics; D012323:RNA Processing, Post-Transcriptional; D012326:RNA Splicing; D012333:RNA, Messenger / Q000378:metabolism*; D013025:Glycine max / Q000737:chemistry*
chemical_list: D007529:Isoflavones; D012333:RNA, Messenger; D049410:Luciferases, Renilla
keywords: RNA-FISH; Soyaflavone HG; luciferase