title: Vitamin D3supplementation among adult patients with cystic fibrosis.
abstract: Vitamin D (Vit D) deficiency in cystic fibrosis (CF) is partially secondary to exocrine pancreatic insufficiency. Our aim was to establish a Vit D3supplementation protocol that will increase 25(OH)D to the recommended level (30 ng/mL).
  
  
  
  Retrospective study of 200 patients (≥18 years) conducted from February 2007 to June 2014 at the CF clinic of the Centre Hospitalier de l'Université de Montréal. Vit D3supplementation protocol was 1600 IU/day or 10,000 IU/week during the summer (May 1st to October 31st) and 3200 IU/day or 20,000 IU/week during the winter (November 1st to April 30th), in addition to the 1200 IU/day included in multivitamins.
  
  
  
  Significant increase in serum 25(OH)D levels from baseline (25.9 ± 10.3 ng/mL) to follow-up (37.0 ± 11.4 ng/mL) (P ≤ 0.001). At follow-up, increased doses during the winter improved serum 25(OH)D levels to a degree comparable to the summer.
  
  
  
  This supplementation protocol is efficient and needs to be tested in other CF adult cohorts and correlated to potential health benefit measurements.
authors: Institut de recherches cliniques de Montréal, Montréal, Québec, H2W 1R7, Canada; Department of Nutrition, Université de Montréal, Montréal, Québec, H3T 1A8, Canada.
authors: Adèle
authors: A
authors: Coriati
authors: Institut de recherches cliniques de Montréal, Montréal, Québec, H2W 1R7, Canada; Department of Medicine, Université de Montréal, Montréal, Québec, H3T 1J4, Canada.
authors: Évelyne
authors: É
authors: Labrèche
authors: Cystic Fibrosis Clinic of the Centre Hospitalier de l'Université de Montréal, Montréal, Québec, H2W 1T8, Canada.
authors: Marjolaine
authors: M
authors: Mailhot
authors: Department of Medicine, Université de Montréal, Montréal, Québec, H3T 1J4, Canada; Cystic Fibrosis Clinic of the Centre Hospitalier de l'Université de Montréal, Montréal, Québec, H2W 1T8, Canada.
authors: Hortensia
authors: H
authors: Mircescu
authors: Institut de recherches cliniques de Montréal, Montréal, Québec, H2W 1R7, Canada; Department of Medicine, Université de Montréal, Montréal, Québec, H3T 1J4, Canada; Cystic Fibrosis Clinic of the Centre Hospitalier de l'Université de Montréal, Montréal, Québec, H2W 1T8, Canada.
authors: Yves
authors: Y
authors: Berthiaume
authors: Cystic Fibrosis Clinic of the Centre Hospitalier de l'Université de Montréal, Montréal, Québec, H2W 1T8, Canada.
authors: Annick
authors: A
authors: Lavoie
authors: Institut de recherches cliniques de Montréal, Montréal, Québec, H2W 1R7, Canada; Department of Nutrition, Université de Montréal, Montréal, Québec, H3T 1A8, Canada; Department of Medicine, Université de Montréal, Montréal, Québec, H3T 1J4, Canada; Cystic Fibrosis Clinic of the Centre Hospitalier de l'Université de Montréal, Montréal, Québec, H2W 1T8, Canada. Electronic address: remi.rabasa-lhoret@ircm.qc.ca.
authors: Rémi
authors: R
authors: Rabasa-Lhoret
mesh_terms: D000328:Adult; D015992:Body Mass Index; D002762:Cholecalciferol / Q000008:administration & dosage* / Q000097:blood; D003550:Cystic Fibrosis / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D019587:Dietary Supplements; D004305:Dose-Response Relationship, Drug; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D012189:Retrospective Studies; D012621:Seasons; D014808:Vitamin D Deficiency / Q000097:blood / Q000188:drug therapy / Q000209:etiology; D055815:Young Adult
chemical_list: D002762:Cholecalciferol
keywords: 25(OH)D; Cystic fibrosis; Summer; Vitamin D supplementation; Winter