title: Oxidized graphene-aggravated allergic asthma is antagonized by antioxidant vitamin E in Balb/c mice.
abstract: Nanomaterials have been widely used in a number of applications; however, these nanomaterials may potentially be risky for human health, particularly for the respiratory system. In this study, we used a mouse asthma model to study whether graphene oxide (GO), a promising carbonaceous nanomaterial with unique physicochemical properties, aggravates allergic asthma via the oxidative stress pathway. Mice were sensitized with ovalbumin (OVA) to trigger immune reactions, while vitamin E (Ve) was administered as an antioxidant. Our results showed that GO aggravated OVA-induced allergic asthma in mice, as suggested by increased reactive oxygen species (ROS), elevated total immunoglobulin E (IgE), upregulated Th2 response, and the aggravation of allergic asthma symptoms, such as airway remolding, collagen deposition with mucus hypersecretion, and airway hyperresponsiveness (AHR). The administration of Ve dramatically attenuated all of the above effects. In conclusion, Ve showed anti-allergic properties in antagonizing the exacerbation of allergic asthma induced by GO, providing a new possibility for the treatment of allergic asthma.
authors: Laboratory of Environmental Biomedicine, Hubei Key Laboratory of Genetic Regulation and Integrative Biology, College of Life Science, Central China Normal University, Wuhan, Hubei Province, 430079, China.
authors: Shuai
authors: S
authors: Shang
authors: Laboratory of Environmental Biomedicine, Hubei Key Laboratory of Genetic Regulation and Integrative Biology, College of Life Science, Central China Normal University, Wuhan, Hubei Province, 430079, China.|National Centre for International Research of Low-carbon and Green Buildings, Chongqing University, Chongqing, 400045, People's Republic of China.
authors: Jinquan
authors: J
authors: Li
authors: Laboratory of Environmental Biomedicine, Hubei Key Laboratory of Genetic Regulation and Integrative Biology, College of Life Science, Central China Normal University, Wuhan, Hubei Province, 430079, China.
authors: Yun
authors: Y
authors: Zhao
authors: Institute of Health and Environmental Medicine, Dali Road, Heping District, Tianjin, 300050, People's Republic of China.
authors: Zhuge
authors: Z
authors: Xi
authors: Institute for Clean Energy and Advanced Materials, Southwest University, Chongqing, 400715, People's Republic of China.
authors: Zhisong
authors: Z
authors: Lu
authors: National Centre for International Research of Low-carbon and Green Buildings, Chongqing University, Chongqing, 400045, People's Republic of China.
authors: Baizhan
authors: B
authors: Li
authors: Laboratory of Environmental Biomedicine, Hubei Key Laboratory of Genetic Regulation and Integrative Biology, College of Life Science, Central China Normal University, Wuhan, Hubei Province, 430079, China. yangxu@mail.ccnu.edu.cn.
authors: Xu
authors: X
authors: Yang
authors: Laboratory of Environmental Biomedicine, Hubei Key Laboratory of Genetic Regulation and Integrative Biology, College of Life Science, Central China Normal University, Wuhan, Hubei Province, 430079, China. ruili@mail.ccnu.edu.cn.
authors: Rui
authors: R
authors: Li
mesh_terms: D000818:Animals; D018926:Anti-Allergic Agents / Q000627:therapeutic use*; D000975:Antioxidants / Q000627:therapeutic use*; D001249:Asthma / Q000209:etiology* / Q000517:prevention & control; D004195:Disease Models, Animal; D006108:Graphite / Q000009:adverse effects* / Q000037:antagonists & inhibitors*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010047:Ovalbumin; D012130:Respiratory Hypersensitivity; D014810:Vitamin E / Q000627:therapeutic use*
chemical_list: D018926:Anti-Allergic Agents; D000975:Antioxidants; D014810:Vitamin E; D006108:Graphite; D010047:Ovalbumin
keywords: Allergic asthma; Exacerbation effect; Graphene oxide; Oxidative stress; Vitamin E