title: miR-155: A Novel Target in Allergic Asthma.
abstract: MicroRNAs (miRNAs), a class of small non-coding RNAs of 18-24 nucleotides in length, function to posttranscriptionally regulate protein expression. miR-155 was one of the first identified and, to date, the most studied miRNA, and has been linked to various cellular processes such as modulation of immune responses and oncogenesis. Previous studies have identified miR-155 as a crucial positive regulator of Th1 immune response in autoimmune diseases, but as a suppressor of Th2 immunity in allergic disorders. However, recent studies have found new evidence that miR-155 plays an indispensible role in allergic asthma. This review summarizes the recent findings with respect to miR-155 in immune responses and the underlying mechanisms responsible for miR-155-related allergic diseases, as well as the similarities between miR-155 and glucocorticoids in immunity.
authors: Department of Respiratory Medicine, The Second Affiliated Hospital of Jilin University, Changchun 130041, China. zhouhong0870@mails.jlu.edu.cn.
authors: Hong
authors: H
authors: Zhou
authors: Department of Respiratory Medicine, The Second Affiliated Hospital of Jilin University, Changchun 130041, China. lijunyao191@126.com.
authors: Junyao
authors: J
authors: Li
authors: Department of Respiratory Medicine, The Second Affiliated Hospital of Jilin University, Changchun 130041, China. pengg@126.com.
authors: Peng
authors: P
authors: Gao
authors: Department of Respiratory Medicine, The Second Affiliated Hospital of Jilin University, Changchun 130041, China. wangqi5608319@163.com.
authors: Qi
authors: Q
authors: Wang
authors: Department of Respiratory Medicine, The Second Affiliated Hospital of Jilin University, Changchun 130041, China. doctorzhangj@sina.com.
authors: Jie
authors: J
authors: Zhang
mesh_terms: D000818:Animals; D001249:Asthma / Q000235:genetics / Q000276:immunology* / Q000473:pathology / Q000628:therapy; D005786:Gene Expression Regulation; D015316:Genetic Therapy; D005938:Glucocorticoids / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular; D035683:MicroRNAs / Q000235:genetics / Q000276:immunology*; D018417:Th1 Cells / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D018418:Th2 Cells / Q000276:immunology / Q000378:metabolism / Q000473:pathology
chemical_list: D005938:Glucocorticoids; C524942:MIRN155 microRNA, human; D035683:MicroRNAs
keywords: allergic disease; asthma; glucocorticoid; immune response; miR-155