title: Minimally Invasive Extracorporeal Circulation Circuit Is Not Inferior to Off-Pump Coronary Artery Bypass Grafting: Meta-Analysis Using the Bayesian Method.
abstract: The pathophysiologic side effects of cardiopulmonary bypass have already been identified. Minimally invasive extracorporeal circulation technologies (MiECT) and off-pump coronary artery bypass graft surgery (OPCABG) aim to reduce these problems. This meta-analysis provides a comparison of MiECT and OPCABG in randomized and observational studies. A fully probabilistic, Bayesian approach of primary and secondary endpoints was conducted. MiECT does not give inferior results when compared with OPCABG. However, there is a trend to borderline significantly higher blood loss in this group in randomized controlled trials. The question whether MiECT is equivalent to OPCABG can be answered with the affirmative, but long-term follow-up data are needed to detect any advantage over time.
authors: Department of Cardiovascular Surgery, Inselspital, University of Bern, Bern, Switzerland.
authors: Bernhard
authors: B
authors: Winkler
authors: Department of Cardiovascular Surgery, Inselspital, University of Bern, Bern, Switzerland. Electronic address: ppheinisch@googlemail.com.
authors: Paul P
authors: PP
authors: Heinisch
authors: Department of Cardiovascular Surgery, Inselspital, University of Bern, Bern, Switzerland.
authors: Brigitta
authors: B
authors: Gahl
authors: Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.
authors: Soheila
authors: S
authors: Aghlmandi
authors: Department of Cardiovascular Surgery, Inselspital, University of Bern, Bern, Switzerland.
authors: Hans Jörg
authors: HJ
authors: Jenni
authors: Department of Cardiovascular Surgery, Inselspital, University of Bern, Bern, Switzerland.
authors: Thierry P
authors: TP
authors: Carrel
mesh_terms: D001499:Bayes Theorem; D047549:Coronary Artery Bypass, Off-Pump / Q000379:methods*; D003324:Coronary Artery Disease / Q000601:surgery*; D005112:Extracorporeal Circulation / Q000379:methods*; D006801:Humans; D019060:Minimally Invasive Surgical Procedures / Q000379:methods*