title: Effects of continuous positive airway pressure on energy intake in obstructive sleep apnea: A pilot sham-controlled study.
abstract: Obesity is among the leading risk factors for obstructive sleep apnea (OSA). A reciprocal relationship between obesity and OSA has been proposed, which may be due to excessive food intake. We conducted a pilot study to test the effects of continuous positive airway pressure (CPAP) on energy intake (EI) in OSA patients using a sham-controlled crossover design. In-laboratory total daily EI was assessed after 2mo of active and sham CPAP. Four men were enrolled (age±SEM: 51.8±2.1y; body mass index: 31.5±1.5kg/m2). All received active treatment first. Meals (breakfast, lunch, dinner, snack) were served in excess portions at fixed times and additional palatable snacks were freely available throughout the day. Total EI was lower after active (3744±511kcal/d) vs. sham (4030±456kcal/d) CPAP but this difference was not significant (p=0.51) due to variability in the free snack intake. When only fixed eating occasions were considered, daily EI was significantly lower in the active (3105±513kcal/d) vs. sham (3559±420kcal/d) condition (p=0.006). This small pilot and feasibility study is the first to utilize a sham-controlled design to investigate the effects of CPAP treatment on objective measures of EI. Findings suggest that CPAP may cause a reduction in fixed meal intake. In demonstrating feasibility of study methodology, our study also suggests a larger randomized sham-controlled trial be conducted to fully characterize the effects of CPAP treatment on EI and energy balance overall.
authors: New York Obesity Research Center, Department of Medicine, Columbia University, New York, NY, United States. Electronic address: as4874@columbia.edu.
authors: Ari
authors: A
authors: Shechter
authors: New York Obesity Research Center, Department of Medicine, Columbia University, New York, NY, United States; Institute of Human Nutrition, College of Physicians & Surgeons, Columbia University, New York, NY, United States.
authors: Kyle
authors: K
authors: Kovtun
authors: New York Obesity Research Center, Department of Medicine, Columbia University, New York, NY, United States; Institute of Human Nutrition, College of Physicians & Surgeons, Columbia University, New York, NY, United States.
authors: Marie-Pierre
authors: MP
authors: St-Onge
mesh_terms: D045422:Continuous Positive Airway Pressure; D018592:Cross-Over Studies; D002149:Energy Intake / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications; D010865:Pilot Projects; D017286:Polysomnography; D020181:Sleep Apnea, Obstructive / Q000503:physiopathology*
keywords: CPAP; Food intake; Obesity; Sleep apnea