title: Thermoresponsive Delivery of Paclitaxel by β-Cyclodextrin-Based Poly(N-isopropylacrylamide) Star Polymer via Inclusion Complexation.
abstract: Paclitaxel (PTX), a hydrophobic anticancer drug, is facing several clinical limitations such as low bioavailability and drug resistance. To solve the problems, a well-defined β-cyclodextrin-poly(N-isopropylacrylamide) star polymer was synthesized and used as a nanocarrier to improve the water solubility and aim to thermoresponsive delivery of PTX to cancer cells. The star polymer was able to form supramolecular self-assembled inclusion complex with PTX via host-guest interaction at room temperature, which is below the low critical solution temperature (LCST) of the star polymer, significantly improving the solubilization of PTX. At body temperature (above LCST), the phase transition of poly(N-isopropylacrylamide) segments induced the formation of nanoparticles, which greatly enhanced the cellular uptake of the polymer-drug complex, resulting in efficient thermoresponsive delivery of PTX. In particular, the polymer-drug complex exhibited better antitumor effects than the commercial formulation of PTX in overcoming the multi-drug resistance in AT3B-1 cells.
authors: Department of Biomedical Engineering, Faculty of Engineering, Faculty of Engineering, National University of Singapore , 7 Engineering Drive 1, Singapore 117574, Singapore.
authors: Xia
authors: X
authors: Song
authors: Department of Biomedical Engineering, Faculty of Engineering, Faculty of Engineering, National University of Singapore , 7 Engineering Drive 1, Singapore 117574, Singapore.
authors: Yuting
authors: Y
authors: Wen
authors: Department of Biomedical Engineering, Faculty of Engineering, Faculty of Engineering, National University of Singapore , 7 Engineering Drive 1, Singapore 117574, Singapore.
authors: Jing-Ling
authors: JL
authors: Zhu
authors: Department of Biomedical Engineering, Faculty of Engineering, Faculty of Engineering, National University of Singapore , 7 Engineering Drive 1, Singapore 117574, Singapore.
authors: Feng
authors: F
authors: Zhao
authors: Institute of Materials Research and Engineering, A*STAR (Agency for Science, Technology and Research) , 2 Fusionopolis Way, Singapore 138634, Singapore.
authors: Zhong-Xing
authors: ZX
authors: Zhang
authors: Department of Biomedical Engineering, Faculty of Engineering, Faculty of Engineering, National University of Singapore , 7 Engineering Drive 1, Singapore 117574, Singapore.
authors: Jun
authors: J
authors: Li
mesh_terms: D000178:Acrylamides / Q000737:chemistry*; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D016503:Drug Delivery Systems; D018432:Drug Resistance, Multiple / Q000187:drug effects; D019008:Drug Resistance, Neoplasm / Q000187:drug effects; D002479:Inclusion Bodies; D008297:Male; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry; D017239:Paclitaxel / Q000008:administration & dosage / Q000494:pharmacology*; D011108:Polymers / Q000008:administration & dosage* / Q000737:chemistry; D011471:Prostatic Neoplasms / Q000188:drug therapy*; D051381:Rats; D013696:Temperature; D014407:Tumor Cells, Cultured; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D000178:Acrylamides; D000972:Antineoplastic Agents, Phytogenic; D011108:Polymers; D047392:beta-Cyclodextrins; C067295:N-isopropylacrylamide; D017239:Paclitaxel