title: Generation and characterization of mice bearing null alleles of nradd/Nrh2.
abstract: The Neurotrophin receptor associated death domain gene (Nradd/Nrh2/Plaidd) is a type I transmembrane protein with a unique and short N-terminal extracellular domain and a transmembrane and intracellular domain that bears high similarity to the p75 neurotrophin receptor (p75NTR/Ngfr). Initial studies suggested that NRADD regulates neurotrophin signaling but very little is known about its physiological roles. We have generated and characterized NRADD conditional and germ-line null mouse lines. These mice are viable and fertile and dońt show evident abnormalities. However, NRADD deletion results in an increase in the proportion of dorsal root ganglion neurons expressing p75NTR. The NRADD conditional and complete knockout mouse lines generated are new and useful tools to study the physiological roles of NRADD. Birth Defects Research (Part A) 106:605-612, 2016. © 2016 Wiley Periodicals, Inc.
authors: Laboratorio de Neurobiología, Instituto de Investigación Médica Mercedes y Martín Ferreyra, INIMEC-CONICET, Universidad Nacional de Córdoba, Friuli 2434, Córdoba, 5016, Argentina.
authors: Nicolas
authors: N
authors: Unsain
authors: Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QCH3A 2B4, Canada.
authors: Genevieve
authors: G
authors: Dorval
authors: Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QCH3A 2B4, Canada.
authors: Jae Hyung
authors: JH
authors: Sheen
authors: Vice Principal Research University of British Columbia, Okanagan Campus, 3247 University Way, Kelowna, British Columbia, V1V1V7, Canada.
authors: Philip A
authors: PA
authors: Barker
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000235:genetics; D002460:Cell Line; D005727:Ganglia, Spinal / Q000378:metabolism; D008562:Membrane Glycoproteins / Q000235:genetics*; D051379:Mice; D018345:Mice, Knockout; D009414:Nerve Growth Factors / Q000235:genetics*; D009474:Neurons / Q000378:metabolism; D053218:Receptors, Death Domain / Q000235:genetics*; D017475:Receptors, Nerve Growth Factor / Q000235:genetics*; D017386:Sequence Homology, Amino Acid; D015398:Signal Transduction
chemical_list: D008562:Membrane Glycoproteins; C476128:NRH2 protein, mouse; D009414:Nerve Growth Factors; C480683:Nradd protein, mouse; D053218:Receptors, Death Domain; D017475:Receptors, Nerve Growth Factor; C517634:Ngfr protein, mouse
keywords: NRH2; P75NTR; PLAIDD; neurotrophin receptors