title: Channel-transporter complexes: an emerging theme in cell signaling.
abstract: In a recent edition of Biochemical Journal, Mistry et al. described the discovery of a novel protein complex, formed from the epithelial sodium channel (ENaC) and the sodium chloride cotransporter (NCC) [Mistry et al. (2016) Biochem. J. 473, 3237–3252]. The importance of these two proteins in the regulation of salt balance and blood pressure has long been known, as has their overlapping expression in the distal convoluted tubule of the kidney. The new study by Mistry et al. now demonstrates their physical interaction in the kidney and when heterologously co-expressed. Furthermore, the authors demonstrate some degree of functional co-dependence between ENaC and NCC, with pharmacological inhibition of the latter diminishing activity of the former when the two are co-assembled. This novel and potentially important interaction adds to a growing number of recently identified channel-transporter ('chansporter') complexes, which together constitute an emerging theme in cell signaling.
authors: Bioelectricity Laboratory, Department of Pharmacology and Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, CA, USA.
authors: Geoffrey W
authors: GW
authors: Abbott
mesh_terms: D000818:Animals; D053503:Epithelial Sodium Channels / Q000235:genetics / Q000378:metabolism*; D050485:GABA Plasma Membrane Transport Proteins / Q000235:genetics / Q000378:metabolism; D006360:Heat-Shock Proteins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D051657:KCNQ1 Potassium Channel / Q000235:genetics / Q000378:metabolism; D051658:KCNQ2 Potassium Channel / Q000235:genetics / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D051036:Large-Conductance Calcium-Activated Potassium Channels / Q000235:genetics / Q000378:metabolism; D024642:Potassium Channels, Voltage-Gated / Q000235:genetics / Q000378:metabolism; D011485:Protein Binding / Q000235:genetics / Q000502:physiology; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology*; D049992:Sodium Chloride Symporters / Q000235:genetics / Q000378:metabolism*; D027981:Symporters / Q000235:genetics / Q000378:metabolism
chemical_list: D053503:Epithelial Sodium Channels; D050485:GABA Plasma Membrane Transport Proteins; D006360:Heat-Shock Proteins; C489619:KCNE2 protein, human; D051657:KCNQ1 Potassium Channel; D051658:KCNQ2 Potassium Channel; D051036:Large-Conductance Calcium-Activated Potassium Channels; D024642:Potassium Channels, Voltage-Gated; C493416:SLC6A11 protein, human; D049992:Sodium Chloride Symporters; D027981:Symporters; C073884:SLC5A3 protein, human
keywords: neuronal ion transport; physiology; potassium channels; renal ion transport; sodium channels; transport