title: p62 in Cancer: Signaling Adaptor Beyond Autophagy.
abstract: Adaptor proteins participate in selective autophagy, which is critical for cellular detoxification and stress relief. However, new evidence supports an autophagy-independent key role of the adaptor p62 (encoded by the gene Sqstm1) in signaling functions central to tumor initiation in the epithelium and suppression of tumor progression in the stroma.
authors: Cancer Metabolism and Signaling Networks Program, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address: jmoscat@sbpdiscovery.org.
authors: Jorge
authors: J
authors: Moscat
authors: Laboratory of Signal Transduction and Gene Regulation Departments of Pharmacology and Pathology, University of California San Diego, 9500 Gilman Drive, La Jolla Ca 92093, USA.
authors: Michael
authors: M
authors: Karin
authors: Cancer Metabolism and Signaling Networks Program, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.
authors: Maria T
authors: MT
authors: Diaz-Meco
mesh_terms: D001343:Autophagy; D063646:Carcinogenesis / Q000378:metabolism / Q000473:pathology*; D004847:Epithelial Cells / Q000378:metabolism / Q000473:pathology; D006801:Humans; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology*; D000071456:Sequestosome-1 Protein / Q000378:metabolism*; D015398:Signal Transduction; D013312:Stress, Physiological; D059016:Tumor Microenvironment
chemical_list: C099718:SQSTM1 protein, human; D000071456:Sequestosome-1 Protein