title: Thickness of macular inner retinal layers and peripapillary retinal nerve fibre layer in neuromyelitis optica spectrum optic neuritis and isolated optic neuritis with one episode.
abstract: OBJECTIVE
  The aim of this study was to evaluate the differences between macular inner retinal layers and peripapillary retinal nerve fibre layer (pRNFL) thickness in Chinese patients with neuromyelitis spectrum optic neuritis (NMOSD-ON) and isolated optic neuritis (ION) with only one episode.
  
  
  METHODS
  This cross-sectional study included 35 patients (35 eyes) with NMOSD-ON (NMO-IgG seropositive) and 46 patients (46 eyes) with ION after one episode. Spectral domain optical coherence tomography (SD-OCT) was used to quantify pRNFL, macular RNFL (mRNFL), ganglion cell and inner plexiform layers (GCIPL) and inner nuclear layer (INL) thickness using an automated algorithm. Differences in OCT parameters between NMOSD-ON and ION were compared after adjusting for age, sex and disease duration.
  
  
  RESULTS
  The pRNFL and mRNFL in some locations (average pRNFL, nasal pRNFL, nasal inferior (NI) pRNFL, nasal/temporal (N/T) ratio pRNFL, average mRNFL, inner temporal mRNFL, outer nasal mRNFL and outer temporal mRNFL) in NMOSD-ON differed significantly from those in ION (all p < 0.05). These parameters had moderate diagnostic accuracy, with area under curves (AUCs) ranging from 0.684 to 0.762 for pRNFL and from 0.660 to 0.700 for mRNF. The thickness of GC-IPL and INL in all sectors was similar in NMOSD-ON and ION (p > 0.05). This study and our meta-analysis of four previous studies obtained consistent results, with pooled mean difference (MD) -10.4 μm (95% CI: -12.4 to -8.4, p < 0.001) for pRNFL, -1.5 μm (95% CI: -3.5 to 0.6, p = 0.158) for mRNFL and 0.2 μm (95% CI: -0.4 to 0.9, p = 0.490) for GC-IPL, respectively.
  
  
  CONCLUSIONS
  Neuromyelitis spectrum optic neuritis (NMOSD-ON) patients had more pRNFL and mRNFL loss compared to ION patients after one episode. Spectral domain optical coherence tomography (SD-OCT) may help to distinguish NMOSD-ON from ION with only moderate diagnostic accuracy.
authors: Department of Ophthalmology, Chinese PLA General Hospital, Beijing, China.
authors: Chunxia
authors: http://orcid.org/0000-0001-6618-4410
authors: C
authors: Peng
authors: Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-Sen University, Guangzhou, China.
authors: Wei
authors: http://orcid.org/0000-0002-5273-3332
authors: W
authors: Wang
authors: Department of Ophthalmology, Chinese PLA General Hospital, Beijing, China.|Department of Neurology, Chinese PLA General Hospital, Beijing, China.
authors: Quangang
authors: Q
authors: Xu
authors: Department of Ophthalmology, Chinese PLA General Hospital, Beijing, China.
authors: Mo
authors: M
authors: Yang
authors: Department of Ophthalmology, Chinese PLA General Hospital, Beijing, China.
authors: Huangfen
authors: H
authors: Zhou
authors: Department of Ophthalmology, Chinese PLA General Hospital, Beijing, China.
authors: Shuo
authors: S
authors: Zhao
authors: Department of Ophthalmology, Chinese PLA General Hospital, Beijing, China.
authors: Shihui
authors: S
authors: Wei
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008266:Macula Lutea / Q000473:pathology*; D008297:Male; D009412:Nerve Fibers / Q000473:pathology*; D009471:Neuromyelitis Optica / Q000175:diagnosis*; D009898:Optic Disk / Q000473:pathology*; D009902:Optic Neuritis / Q000175:diagnosis*; D015203:Reproducibility of Results; D012165:Retinal Ganglion Cells / Q000473:pathology*; D055211:Retinal Photoreceptor Cell Inner Segment / Q000473:pathology*; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence / Q000379:methods
keywords: 
  OCT
  ; multiple sclerosis; neuromyelitis optica; optic neuritis