title: Silk fibroin membrane used for guided bone tissue regeneration.
abstract: With the aim to develop a novel membrane with an appropriate mechanical property and degradation rate for guided bone tissue regeneration, lyophilized and densified silk fibroin membrane was fabricated and its mechanical behavior as well as biodegradation property were investigated. The osteoconductive potency of the silk fibroin membranes were evaluated in a defect rabbit calvarial model. Silk fibroin membrane showed the modulated biodegradable and mechanical properties via ethanol treatment with different concentration. The membrane could prevent soft tissue invasion from normal tissue healing, and the amounts of new bone and defect closure with silk fibroin membrane were similar to those of commercially available collagen membrane.
authors: The Key Laboratory of Advanced Textile Materials and Manufacturing Technology of Ministry of Education, National Engineering Lab for Textile Fiber Materials and Processing Technology(Zhejiang), College of Materials and Textiles, Zhejiang Sci-Tech University, Hangzhou 310018, China.
authors: Yurong
authors: Y
authors: Cai
authors: The Key Laboratory of Advanced Textile Materials and Manufacturing Technology of Ministry of Education, National Engineering Lab for Textile Fiber Materials and Processing Technology(Zhejiang), College of Materials and Textiles, Zhejiang Sci-Tech University, Hangzhou 310018, China.
authors: Junmao
authors: J
authors: Guo
authors: Bio-X Center, College of Life Sciences, Zhejiang Sci-Tech University, Hangzhou 310018, China.
authors: Cen
authors: C
authors: Chen
authors: Bio-X Center, College of Life Sciences, Zhejiang Sci-Tech University, Hangzhou 310018, China.
authors: Chenxue
authors: C
authors: Yao
authors: Sung-Min Chung Genoss Co., Ltd., Suwon 443-270, Republic of Korea.
authors: Sung-Min
authors: SM
authors: Chung
authors: The Key Laboratory of Advanced Textile Materials and Manufacturing Technology of Ministry of Education, National Engineering Lab for Textile Fiber Materials and Processing Technology(Zhejiang), College of Materials and Textiles, Zhejiang Sci-Tech University, Hangzhou 310018, China.
authors: Juming
authors: J
authors: Yao
authors: Institute of Natural Sciences, Yonsei University, 134 Shinchon-dong, Seodaemoon-gu, Seoul 120-749, Republic of Korea.
authors: In-Seop
authors: IS
authors: Lee
authors: Bio-X Center, College of Life Sciences, Zhejiang Sci-Tech University, Hangzhou 310018, China. Electronic address: kongxiangdong@gmail.com.
authors: Xiangdong
authors: X
authors: Kong
mesh_terms: D000818:Animals; D012831:Bombyx; D001861:Bone Regeneration / Q000187:drug effects*; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000473:pathology; D005349:Fibroins / Q000494:pharmacology*; D048091:Guided Tissue Regeneration / Q000379:methods*; D008297:Male; D008567:Membranes, Artificial; D008970:Molecular Weight; D010012:Osteogenesis / Q000187:drug effects; D011817:Rabbits; D017550:Spectroscopy, Fourier Transform Infrared; D013718:Tensile Strength; D055114:X-Ray Microtomography
chemical_list: D008567:Membranes, Artificial; D005349:Fibroins
keywords: Degradable; Guided bone regeneration; Mechanical properties; Osteoconductive; Silk fibroin