title: [Serum levels of vitamin D in systemic lupus erythematosus patients (SLE) and their relationship with disease activity: longitudinal study].
abstract: OBJECTIVE
  To determine changes over time of serum levels of 25-hydroxy vitamin D (25(OH)D) in Mexican patients with SLE and their relationship with disease activity.
  
  
  METHODS
  Longitudinal and observational study. Women with SLE were included. Serum levels of 25(OH)D were measured at baseline and after two years; the disease activity was measured with MEX-SLEDAI. Patients with initial suboptimal levels of 25(OH)D received supplements or increased doses of calcitriol.
  
  
  RESULTS
  105 women with SLE were included, mean age 49.4 ± 11 years. Serum levels of 25(OH)D were higher at two years (baseline 20 ± 6.8 vs. follow-up 22.7 ± 7.7; p = < 0.001). There were no differences between disease activity scores at baseline and two years (baseline 1.7 ± 1.9 vs. follow-up 1.1 ± 1.7; p = 0.7). Serum levels of 25(OH)D did not correlate with disease activity during the follow up, p = 0.7. No correlation was found between changes in MEX-SLEDAI scores and serum levels of 25(OH)D, p = 0.87.
  
  
  CONCLUSIONS
  Mexican women with SLE had increased serum levels of 25(OH)D. No correlation between serum levels of 25(OH)D and disease activity was found.
authors: Unidad de Investigación de Enfermedades Autoinmunes Sistémicas, Hospital General Regional No. 36, IMSS, Puebla, Pue., México.|Departamento de Reumatología e Inmunología, Facultad de Medicina, Benemérita Universidad Autónoma de Puebla, Puebla, Pue., México.
authors: Mario
authors: M
authors: García-Carrasco
authors: Unidad de Investigación de Enfermedades Autoinmunes Sistémicas, Hospital General Regional No. 36, IMSS, Puebla, Pue., México.|Departamento de Reumatología e Inmunología, Facultad de Medicina, Benemérita Universidad Autónoma de Puebla, Puebla, Pue., México.
authors: Claudia
authors: C
authors: Mendoza-Pinto
authors: Unidad de Investigación de Enfermedades Autoinmunes Sistémicas, Hospital General Regional No. 36, IMSS, Puebla, Pue., México.
authors: Jorge
authors: J
authors: Ayón-Aguilar
authors: Unidad de Investigación de Enfermedades Autoinmunes Sistémicas, Hospital General Regional No. 36, IMSS, Puebla, Pue., México.
authors: Pamela
authors: P
authors: Soto-Santillán
authors: Laboratorios Clínicos de Puebla, Puebla, Pue., México.
authors: Alma
authors: A
authors: Rodríguez-Gallegos
authors: Departamento de Endocrinología, Centro Médico Nacional Manuel Ávila Camacho, IMSS, Puebla, Pue., México.
authors: Marco Antonio
authors: MA
authors: Escamilla-Márquez
authors: Unidad de Investigación de Enfermedades Autoinmunes Sistémicas, Hospital General Regional No. 36, IMSS, Puebla, Pue., México.
authors: Socorro
authors: S
authors: Méndez-Martínez
mesh_terms: D015652:25-Hydroxyvitamin D 2 / Q000097:blood*; D000328:Adult; D000368:Aged; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008180:Lupus Erythematosus, Systemic / Q000097:blood*; D008800:Mexico; D008875:Middle Aged; D014808:Vitamin D Deficiency / Q000097:blood*
chemical_list: D015652:25-Hydroxyvitamin D 2