title: Intra-Arterial MR Perfusion Imaging of Meningiomas: Comparison to Digital Subtraction Angiography and Intravenous MR Perfusion Imaging.
abstract: OBJECTIVE
  To evaluate the ability of IA MR perfusion to characterize meningioma blood supply.
  
  
  METHODS
  Studies were performed in a suite comprised of an x-ray angiography unit and 1.5T MR scanner that permitted intraprocedural patient movement between the imaging modalities. Patients underwent intra-arterial (IA) and intravenous (IV) T2* dynamic susceptibility MR perfusion immediately prior to meningioma embolization. Regional tumor arterial supply was characterized by digital subtraction angiography and classified as external carotid artery (ECA) dural, internal carotid artery (ICA) dural, or pial. MR perfusion data regions of interest (ROIs) were analyzed in regions with different vascular supply to extract peak height, full-width at half-maximum (FWHM), relative cerebral blood flow (rCBF), relative cerebral blood volume (rCBV), and mean transit time (MTT). Linear mixed modeling was used to identify perfusion curve parameter differences for each ROI for IA and IV MR imaging techniques. IA vs. IV perfusion parameters were also directly compared for each ROI using linear mixed modeling.
  
  
  RESULTS
  18 ROIs were analyzed in 12 patients. Arterial supply was identified as ECA dural (n = 11), ICA dural (n = 4), or pial (n = 3). FWHM, rCBV, and rCBF showed statistically significant differences between ROIs for IA MR perfusion. Peak Height and FWHM showed statistically significant differences between ROIs for IV MR perfusion. RCBV and MTT were significantly lower for IA perfusion in the Dural ECA compared to IV perfusion. Relative CBF in IA MR was found to be significantly higher in the Dural ICA region and MTT significantly lower compared to IV perfusion.
authors: School of Medicine, University of California San Francisco, San Francisco, California, United States of America.
authors: Mark A
authors: http://orcid.org/0000-0002-6634-6413
authors: MA
authors: Lum
authors: Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, United States of America.
authors: Alastair J
authors: AJ
authors: Martin
authors: Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, United States of America.
authors: Matthew D
authors: MD
authors: Alexander
authors: Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, United States of America.
authors: David B
authors: DB
authors: McCoy
authors: Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, United States of America.
authors: Daniel L
authors: DL
authors: Cooke
authors: Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, United States of America.
authors: Prasheel
authors: P
authors: Lillaney
authors: Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, United States of America.
authors: Parham
authors: P
authors: Moftakhar
authors: Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, United States of America.
authors: Matthew R
authors: MR
authors: Amans
authors: Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, United States of America.
authors: Fabio
authors: F
authors: Settecase
authors: Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, United States of America.
authors: Andrew
authors: A
authors: Nicholson
authors: Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, United States of America.|Department of Neurological Surgery, University of California San Francisco, San Francisco, California, United States of America.|Department of Neurology, University of California San Francisco, San Francisco, California, United States of America.|Department of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, California, United States of America.
authors: Christopher F
authors: CF
authors: Dowd
authors: Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, United States of America.|Department of Neurological Surgery, University of California San Francisco, San Francisco, California, United States of America.|Department of Neurology, University of California San Francisco, San Francisco, California, United States of America.|Department of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, California, United States of America.
authors: Van V
authors: VV
authors: Halbach
authors: Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, United States of America.|Department of Neurological Surgery, University of California San Francisco, San Francisco, California, United States of America.|Department of Neurology, University of California San Francisco, San Francisco, California, United States of America.|Department of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, California, United States of America.
authors: Randall T
authors: RT
authors: Higashida
authors: Department of Neurological Surgery, University of California San Francisco, San Francisco, California, United States of America.
authors: Michael W
authors: MW
authors: McDermott
authors: Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, United States of America.
authors: David
authors: D
authors: Saloner
authors: Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, United States of America.
authors: Steven W
authors: SW
authors: Hetts
mesh_terms: D015901:Angiography, Digital Subtraction / Q000379:methods*; D001810:Blood Volume / Q000502:physiology; D001921:Brain / Q000473:pathology; D002342:Carotid Artery, External / Q000473:pathology; D002343:Carotid Artery, Internal / Q000473:pathology*; D002560:Cerebrovascular Circulation / Q000502:physiology; D003287:Contrast Media / Q000008:administration & dosage; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008577:Meningeal Neoplasms / Q000473:pathology*; D008579:Meningioma / Q000473:pathology*; D055420:Perfusion Imaging / Q000379:methods*
chemical_list: D003287:Contrast Media