title: miRNA Biogenesis: A Dynamic Pathway.
abstract: MicroRNAs (miRNAs) modulate plant homeostasis through the inactivation of specific mRNAs, especially those encoding transcription factors. A delicate spatial/temporal balance between a miRNA and its targets is central to achieving the appropriate biological outcomes. In this review we discuss our growing understanding of the dynamic regulation of miRNA biogenesis. We put special emphasis on crosstalk between miRNA biogenesis and other cellular processes such as transcription and splicing. We also discuss how the pathway is regulated in specific tissues to achieve harmonious plant development through a subtle balance between gene expression and silencing.
authors: Instituto de Agrobiotecnología del Litoral, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Facultad de Bioquímica y Ciencias Biológicas (FBCB), Universidad Nacional del Litoral (UNL), Paraje El Pozo, 3000 Santa Fe, Argentina.
authors: Natalia P
authors: NP
authors: Achkar
authors: Instituto de Agrobiotecnología del Litoral, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Facultad de Bioquímica y Ciencias Biológicas (FBCB), Universidad Nacional del Litoral (UNL), Paraje El Pozo, 3000 Santa Fe, Argentina.
authors: Damián A
authors: DA
authors: Cambiagno
authors: Instituto de Agrobiotecnología del Litoral, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Facultad de Bioquímica y Ciencias Biológicas (FBCB), Universidad Nacional del Litoral (UNL), Paraje El Pozo, 3000 Santa Fe, Argentina. Electronic address: pablomanavella@ial.santafe-conicet.gov.ar.
authors: Pablo A
authors: PA
authors: Manavella
mesh_terms: D005786:Gene Expression Regulation / Q000235:genetics / Q000502:physiology; D035683:MicroRNAs / Q000378:metabolism*; D012323:RNA Processing, Post-Transcriptional; D012326:RNA Splicing / Q000235:genetics / Q000502:physiology; D012333:RNA, Messenger / Q000378:metabolism
chemical_list: D035683:MicroRNAs; D012333:RNA, Messenger
keywords: gene silencing; miRNA biogenesis; microRNA; small RNA; splicing.