title: Generation of induced pluripotent stem cells derived from a 77-year-old healthy woman as control for age related diseases.
abstract: Induced pluripotent stem cells (iPSCs) hold great promise to model diseases, where the disease affected cell type is difficult to access. A major obstacle for the development of disease models is the lack of well characterized control iPSCs from old people not affected by such a disease. Furthermore, gene-editing approaches often require iPSCs from healthy donors, where pathogenic mutations can be inserted if patient material is not available. Here, we report the generation of an iPSC line (16423 #6) from a 77-year-old woman, who did not display any disease symptoms at the time, when the skin biopsy was taken.
authors: Bioneer A/S, Kogle Alle 2, 2970 Hørsholm, Denmark; Department of Clinical Microscopy, Faculty of Medical Technology, Mahidol University, Bangkok, 10700, Thailand.
authors: Natakarn
authors: N
authors: Nimsanor
authors: Bioneer A/S, Kogle Alle 2, 2970 Hørsholm, Denmark.
authors: Ida
authors: I
authors: Jørring
authors: Bioneer A/S, Kogle Alle 2, 2970 Hørsholm, Denmark.
authors: Mikkel A
authors: MA
authors: Rasmussen
authors: Bioneer A/S, Kogle Alle 2, 2970 Hørsholm, Denmark.
authors: Christian
authors: C
authors: Clausen
authors: Institute of Medical Genetics and Applied Genomics, Division of Cytogenetics, Calwerstrasse 7, University of Tübingen, 72076, Germany.
authors: Ulrike A
authors: UA
authors: Mau-Holzmann
authors: Hertie Institute for Clinical Brain Research, University of Tübingen, German Center for Neurodegenerative Diseases, 72076 Tübingen, Germany.
authors: Christine
authors: C
authors: Bus
authors: Hertie Institute for Clinical Brain Research, University of Tübingen, German Center for Neurodegenerative Diseases, 72076 Tübingen, Germany.
authors: Susanna A
authors: SA
authors: Hoffmann
authors: Hertie Institute for Clinical Brain Research, University of Tübingen, German Center for Neurodegenerative Diseases, 72076 Tübingen, Germany.
authors: Thomas
authors: T
authors: Gasser
authors: Klinik für Orthopädie und Orthopädische Chirurgie, Endoprothesenzentrum der Maximalversorgung, Friedrichstraße 41, 01067, Dresden, Germany.
authors: Torsten
authors: T
authors: Kluba
authors: Bioneer A/S, Kogle Alle 2, 2970 Hørsholm, Denmark.
authors: Bjørn
authors: B
authors: Holst
authors: Bioneer A/S, Kogle Alle 2, 2970 Hørsholm, Denmark. Electronic address: bsc@bioneer.dk.
authors: Benjamin
authors: B
authors: Schmid
mesh_terms: D000368:Aged; D002454:Cell Differentiation; D002460:Cell Line; D065150:Cellular Reprogramming; D004475:Ectoderm / Q000166:cytology / Q000378:metabolism; D005260:Female; D005347:Fibroblasts / Q000166:cytology; D064368:Healthy Volunteers; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000166:cytology* / Q000378:metabolism; D059785:Karyotype; D008856:Microscopy, Fluorescence; D012867:Skin / Q000166:cytology; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
chemical_list: D014157:Transcription Factors