title: Dammarane-type triterpene extracts of Panax notoginseng root ameliorates hyperglycemia and insulin sensitivity by enhancing glucose uptake in skeletal muscle.
abstract: Skeletal muscle is an important organ for controlling the development of type 2 diabetes. We discovered Panax notoginseng roots as a candidate to improve hyperglycemia through in vitro muscle cells screening test. Saponins are considered as the active ingredients of ginseng. However, in the body, saponins are converted to dammarane-type triterpenes, which may account for the anti-hyperglycemic activity. We developed a method for producing a dammarane-type triterpene extract (DTE) from Panax notoginseng roots and investigated the extract's potential anti-hyperglycemic activity. We found that DTE had stronger suppressive activity on blood glucose levels than the saponin extract (SE) did in KK-Aymice. Additionally, DTE improved oral glucose tolerance, insulin sensitivity, glucose uptake, and Akt phosphorylation in skeletal muscle. These results suggest that DTE is a promising agent for controlling hyperglycemia by enhancing glucose uptake in skeletal muscle.
authors: a Research and Development Headquarters, Lion Corporation , Odawara , Japan.
authors: Kumiko
authors: K
authors: Kitamura
authors: a Research and Development Headquarters, Lion Corporation , Odawara , Japan.
authors: Yusuke
authors: Y
authors: Takamura
authors: a Research and Development Headquarters, Lion Corporation , Odawara , Japan.
authors: Taku
authors: T
authors: Iwamoto
authors: a Research and Development Headquarters, Lion Corporation , Odawara , Japan.
authors: Mitsuru
authors: M
authors: Nomura
authors: a Research and Development Headquarters, Lion Corporation , Odawara , Japan.
authors: Hideaki
authors: H
authors: Iwasaki
authors: a Research and Development Headquarters, Lion Corporation , Odawara , Japan.
authors: Motoyasu
authors: M
authors: Ohdera
authors: a Research and Development Headquarters, Lion Corporation , Odawara , Japan.
authors: Michiaki
authors: M
authors: Murakoshi
authors: a Research and Development Headquarters, Lion Corporation , Odawara , Japan.
authors: Keikichi
authors: K
authors: Sugiyama
authors: b Department of Health Promotion Sciences , Graduate School of Human Health Sciences, Tokyo Metropolitan University , Hachioji , Japan.
authors: Kazuki
authors: K
authors: Matsuyama
authors: b Department of Health Promotion Sciences , Graduate School of Human Health Sciences, Tokyo Metropolitan University , Hachioji , Japan.
authors: Yasuko
authors: Y
authors: Manabe
authors: b Department of Health Promotion Sciences , Graduate School of Human Health Sciences, Tokyo Metropolitan University , Hachioji , Japan.
authors: Nobuharu L
authors: NL
authors: Fujii
authors: c Division of Food Science and Biotechnology , Graduate School of Agriculture, Kyoto University , Kyoto , Japan.
authors: Tohru
authors: T
authors: Fushiki
mesh_terms: D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D001786:Blood Glucose / Q000378:metabolism*; D004032:Diet; D006943:Hyperglycemia / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000302:isolation & purification / Q000494:pharmacology; D007328:Insulin / Q000097:blood / Q000378:metabolism; D007333:Insulin Resistance; D000078790:Insulin Secretion; D008297:Male; D051379:Mice; D018482:Muscle, Skeletal / Q000187:drug effects / Q000378:metabolism*; D053723:Panax notoginseng / Q000737:chemistry*; D010179:Pancreas / Q000187:drug effects / Q000378:metabolism; D010766:Phosphorylation / Q000187:drug effects; D018517:Plant Roots / Q000737:chemistry*; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism; D012503:Saponins / Q000302:isolation & purification / Q000494:pharmacology; D014315:Triterpenes / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D000516:alpha-Amylases / Q000378:metabolism; D000520:alpha-Glucosidases / Q000378:metabolism; D000097669:Dammaranes
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D051057:Proto-Oncogene Proteins c-akt; D012503:Saponins; D014315:Triterpenes; D000516:alpha-Amylases; D000520:alpha-Glucosidases; D000097669:Dammaranes
keywords: Panax notoginseng; dammarane-type triterpene extract; hyperglycemia; skeletal muscle