title: Assigning Treatment to HCC Patients for Transplantation: Utility of a New Decision-Making Tool.
abstract: BACKGROUND The Barcelona clinic liver cancer (BCLC) staging system is considered the standard of care for hepatocellular carcinoma (HCC) management. It has various limitations, including lack of second-line treatment options and combination therapy. We prospectively collected data on our HCC patients based on a new decision-making tool (NDT). The objective of this study was to determine the applicability of this tool and compare it with BCLC for treatment allocation, in particular with respect to liver transplantation. MATERIAL AND METHODS We retrospectively reviewed HCC patients who were managed based on an NDT that was developed in 2012. All patients whose treatment decision was based on this tool between 2012 and 2015 were included. Comparison was made with BCLC. Survival was compared for patients who underwent liver transplantation. RESULTS Based on the NDT, 406 (40.6%) patients were eligible for curative treatment versus only 22 (2.2%) patients based on BCLC. A total of 58 (5.8%) patients underwent liver transplant based on the NDT, while only 2 (0.2%) were transplantable based on BCLC. Estimated 3-year survival for transplanted patients based on the NDT was 73%. There were 41 (4.1%) stage C and 15 (1.5%) stage D BCLC patients who received transplant based on the NDT. Estimated 3-year survival for stage A, C, and D BCLC patients who received transplantation was 100%,72%, and 67%, respectively (P=0.6). CONCLUSIONS The NDT correctly identified a group of HCC patients for liver transplantation who would otherwise have received palliative treatment based on the BCLC algorithm.
authors: Department of Gastroenterology and Hepatology, Shifa International Hospital, Islamabad, Pakistan.
authors: Najmul Hassan
authors: NH
authors: Shah
authors: Department of HPB Surgery and Liver Transplantation, Shifa International Hospital, Islamabad, Pakistan.
authors: Faisal Saud
authors: FS
authors: Dar
authors: Department of HPB Surgery and Liver Transplantation, Shifa International Hospital, Islamabad, Pakistan.
authors: Abu Bakar Hafeez
authors: AB
authors: Bhatti
authors: Department of Radiology, Shifa International Hospital, Islamabad, Pakistan.
authors: Atif
authors: A
authors: Rana
authors: Department of Gastroenterology and Hepatology, Shifa International Hospital, Islamabad, Pakistan.
authors: Mohammad
authors: M
authors: Salih
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D006528:Carcinoma, Hepatocellular / Q000401:mortality / Q000601:surgery*; D002648:Child; D002675:Child, Preschool; D000066491:Clinical Decision-Making / Q000379:methods*; D019317:Evidence-Based Medicine; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008113:Liver Neoplasms / Q000401:mortality / Q000601:surgery*; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D012189:Retrospective Studies; D055815:Young Adult