title: Diuretic and antiurolithiatic activities of an ethanolic extract ofAcorus calamusL. rhizome in experimental animal models.
abstract: Acorus calamusis a plant commonly used as a traditional herbal medicine and possesses the wide range of pharmacological applications. The present study investigated the diuretic and antiurolithiatic activities of an ethanolic extract ofAcorus calamusL. (Family: Araceae) rhizome (EEAC). For diuretic activity, three doses of EEAC (250, 500 and 750 mg/kg) were studied, and measurement of the urinary volume and electrolytes (Na+and K+) concentration were taken as evaluation parameters. On the other hand, ethylene glycol induced urolithiasis (0.75% v/v in drinking water for 28 days) was used to study the antiurolithiatic effect of EEAC at the oral dose of 750 mg/kg in male Wistar albino rats. CYSTONE (750 mg/kg, p.o.) was used as a standard reference drug in the present study. After completion of the 28-days respective treatments, the level of various urolithiatic promoters in the biological samples (urine, serum and kidney homogenate) and renal function were used as criteria for assessing the antiurolithiatic effect of EEAC. Results indicate that, the EEAC (750 mg/kg, p.o.) produced significant increase in urine volume (p < 0.001) and urinary excretion of Na+and K+electrolytes (p < 0.05) in a pattern comparable to that of furosemide. In ethylene glycol induced urolithiatic model, EEAC significantly (p < 0.05) decreased excretion and deposition of various urolithiatic promoters as compared to urolithiatic control in a pattern comparable to that of CYSTONE. The EEAC supplementation also prevents the impairment of renal functions. The antiurolithiatic mechanism is mediated possibly through diuretic and nephroprotective actions of the active compounds of rhizomes.
authors: Department of Pharmacology, S. J. Thakkar Pharmacy College, Kalawad Road, Rajkot 360 005, Gujarat, India; The National Institute of Complementary Medicine (NICM), Western Sydney University, NSW 2751, Australia.
authors: Hardik
authors: H
authors: Ghelani
authors: Department of Pharmacology, S. J. Thakkar Pharmacy College, Kalawad Road, Rajkot 360 005, Gujarat, India.
authors: Maunik
authors: M
authors: Chapala
authors: Department of Pharmacology, S. J. Thakkar Pharmacy College, Kalawad Road, Rajkot 360 005, Gujarat, India.
authors: Pinakin
authors: P
authors: Jadav
keywords: Acorus calamus; Calcium oxalate; Diuresis; Ethylene glycol; Urolithiasis