title: Catalytic Enantioselective α-Fluorination of 2-Acyl Imidazoles via Iridium Complexes.
abstract: The first highly enantioselective α-fluorination of 2-acyl imidazoles utilizing iridium catalysis has been accomplished. This transformation features mild conditions and a remarkably broad substrate scope, providing an efficient and highly enantioselective approach to obtain a wide range of fluorine-containing 2-acyl imidazoles which are found in a variety of bioactive compounds and prodrugs. A large scale synthesis has also been tested to demonstrate the potential utility of this fluorination method.
authors: State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, P.R. China.
authors: Guo-Qiang
authors: GQ
authors: Xu
authors: State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, P.R. China.
authors: Hui
authors: H
authors: Liang
authors: State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, P.R. China.
authors: Jie
authors: J
authors: Fang
authors: State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, P.R. China.
authors: Zhi-Long
authors: ZL
authors: Jia
authors: State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, P.R. China.
authors: Jian-Qiang
authors: JQ
authors: Chen
authors: State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, P.R. China.
authors: Peng-Fei
authors: PF
authors: Xu
keywords: 2-acyl imidazoles; asymmetric catalysis; enantioselectivity; fluorination; iridium