title: Association of brain-derived neurotrophic factor valine to methionine polymorphism with sexual dysfunction following selective serotonin reuptake inhibitor treatment in female patients with major depressive disorder.
abstract: BACKGROUND
  The occurrence of female sexual dysfunction (FSD) in patients with major depressive disorder (MDD) receiving selective serotonin reuptake inhibitors (SSRIs) treatment gives negative impacts on patients' quality of life and causes treatment discontinuation. We aimed to investigate whether genetic polymorphism of identified candidate gene is associated with FSD in our study population.
  
  
  METHODS
  This is a cross-sectional study. A total of 95 female patients with MDD who met the criteria of the study were recruited and were specifically assessed on the sexual function by trained psychiatrists. Patients' DNA was genotyped for BDNF Val66Met polymorphism using real-time polymerase chain reaction.
  
  
  RESULTS
  The prevalence of FSD in this study is 31.6%. In the FSD group, patients with problematic marriage were significantly more frequent compared with patients who did not have problematic marriage (P = 0.009). Significant association was detected in the lubrication domain with BDNF Val66Met polymorphism (P = 0.030) using additive genetic model, with even stronger association when using the recessive model (P = 0.013).
  
  
  CONCLUSIONS
  This study suggested that there was no significant association between BDNF Val66Met with FSD. However, this polymorphism is significantly associated with lubrication disorder in patients treated with SSRIs.
authors: Pharmacogenomics Laboratory, Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. elianazree@yahoo.com.
authors: Nur Elia
authors: NE
authors: Nazree
authors: Pharmacogenomics Laboratory, Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
authors: Zahurin
authors: Z
authors: Mohamed
authors: Biomedical Research Centre, Sheffield Hallam University, Sheffield, UK.
authors: Gavin P
authors: GP
authors: Reynolds
authors: Pharmacogenomics Laboratory, Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
authors: Shamsul
authors: S
authors: Mohd Zain
authors: Department of Psychiatry, University Kebangsaan Malaysia Medical Center, Kuala Lumpur, Malaysia.
authors: Ruziana
authors: R
authors: Masiran
authors: Department of Psychiatry, University Kebangsaan Malaysia Medical Center, Kuala Lumpur, Malaysia.
authors: Hatta
authors: H
authors: Sidi
authors: Department of Psychological Medicine, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia.
authors: Lu Ann
authors: LA
authors: Chong
authors: Department of Psychological Medicine, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia.
authors: Anne Yee
authors: AY
authors: Hway
authors: Department of Psychological Medicine, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia.
authors: Aida Syarinaz
authors: AS
authors: Adlan
authors: Department of Psychological Medicine, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia.
authors: Nor Zuraida
authors: NZ
authors: Zainal
mesh_terms: D000328:Adult; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D003430:Cross-Sectional Studies; D003865:Major Depressive Disorder / Q000188:drug therapy*; D054541:Family Conflict / Q000523:psychology*; D005260:Female; D006801:Humans; D008715:Methionine / Q000235:genetics; D008875:Middle Aged; D011110:Polymorphism, Genetic; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects*; D012735:Sexual Dysfunction, Physiological / Q000139:chemically induced* / Q000235:genetics* / Q000523:psychology; D014633:Valine / Q000235:genetics
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D008715:Methionine; D017367:Selective Serotonin Reuptake Inhibitors; D014633:Valine; C579455:BDNF protein, human
keywords: brain-derived neurotrophic factor; female sexual dysfunction; major depressive disorder; pharmacogenetics; selective serotonin reuptake inhibitor