title: Multiple sclerosis and alcohol use disorders: In-hospital mortality, extended hospital stays, and overexpenditures.
abstract: BACKGROUND
  The objective of this study was to analyse the impact of alcohol use disorders (AUD) in patients with multiple sclerosis (MS) in terms of in-hospital mortality, extended hospital stays, and overexpenditures.
  
  
  METHODS
  We conducted a retrospective observational study in a sample of MS patients obtained from minimal basic data sets from 87 Spanish hospitals recorded between 2008 and 2010. Mortality, length of hospital stays, and overexpenditures attributable to AUD were calculated. We used a multivariate analysis of covariance to control for such variables as age and sex, type of hospital, type of admission, other addictions, and comorbidities.
  
  
  RESULTS
  The 10,249 patients admitted for MS and aged 18-74 years included 215 patients with AUD. Patients with both MS and AUD were predominantly male, with more emergency admissions, a higher prevalence of tobacco or substance use disorders, and higher scores on the Charlson comorbidity index. Patients with MS and AUD had a very high in-hospital mortality rate (94.1%) and unusually lengthy stays (2.4 days), and they generated overexpenditures (1,116.9euros per patient).
  
  
  CONCLUSIONS
  According to the results of this study, AUD in patients with MS results in significant increases in-hospital mortality and the length of the hospital stay and results in overexpenditures.
authors: Departamento de Medicina Preventiva y Salud Pública, Universidad de Sevilla, Sevilla, España; Servicio de Medicina Preventiva y Salud Pública, Hospital Universitario Virgen Macarena, Sevilla, España.
authors: M
authors: M
authors: Gili-Miner
authors: Departamento de Medicina Preventiva y Salud Pública, Universidad de Sevilla, Sevilla, España; Servicio de Medicina Preventiva y Salud Pública, Hospital Universitario Virgen Macarena, Sevilla, España. Electronic address: jlopezmendez@us.es.
authors: J
authors: J
authors: López-Méndez
authors: Departamento de Medicina Preventiva y Salud Pública, Universidad de Sevilla, Sevilla, España; Servicio de Medicina Preventiva y Salud Pública, Hospital Universitario Virgen Macarena, Sevilla, España.
authors: A
authors: A
authors: Vilches-Arenas
authors: Departamento de Medicina Preventiva y Salud Pública, Universidad de Sevilla, Sevilla, España; Servicio de Medicina Preventiva y Salud Pública, Hospital Universitario Virgen Macarena, Sevilla, España.
authors: G
authors: G
authors: Ramírez-Ramírez
authors: Departamento de Psiquiatría, Universidad de Sevilla, Sevilla, España; Servicio de Salud Mental, Hospital Universitario Virgen Macarena, Sevilla, España.
authors: D
authors: D
authors: Franco-Fernández
authors: Unidad de Documentación Clínica, Hospital Universitario Virgen Macarena, Sevilla, España.
authors: J
authors: J
authors: Sala-Turrens
authors: Departamento de Medicina Preventiva y Salud Pública, Universidad de Sevilla, Sevilla, España.
authors: L
authors: L
authors: Béjar-Prado
keywords: Alcohol use disorders; Costes; Costs; Esclerosis múltiple; Estancia hospitalaria; Hospital stay; Mortalidad; Mortality; Multiple sclerosis; Trastornos asociados al consumo de alcohol