title: Association between the TCF7L2 polymorphism and colorectal cancer does not differ by diabetes and obesity statuses.
abstract: This study evaluated the association between polymorphism in a newly identified locus, rs11196172, located in transcription factors 7-like 2 (TCF7L2) and colorectal cancer (CRC) risk according to diabetes and obesity statuses. A study enrolled 6138 CRC patients and 4367 community controls. The adjusted odds ratios (aORs) with age, sex, smoking, and body mass index of the A allele, compared with the G allele, was 1.08 (95% CI 1.01-1.16). The significantly higher risk of CRC with the A allele remained after adjusting for diabetic status (aOR 1.07, 95% CI 1.01-1.15). When stratified by diabetic or obesity status, significant associations between TCF7L2 polymorphism and CRC risk were limited to non-diabetic or normal-weight subjects. No significant interactions between the A/G allele and diabetes status or the A/G allele and overweight status were found. The results indicated that the TCF7L2 rs11196172 polymorphism increases the risk of CRC independently, with no evidence of an interaction with diabetes or obesity.
authors: Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.
authors: Hyun-Jeong
authors: HJ
authors: Shim
authors: Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, Korea.
authors: Ran
authors: R
authors: Lee
authors: Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, Korea; Center for Creative Biomedical Scientists, Chonnam National University, Gwangju, Korea.
authors: Min-Ho
authors: MH
authors: Shin
authors: Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, Korea.
authors: Hee-Nam
authors: HN
authors: Kim
authors: Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, Korea; Jeonnam Regional Cancer center, Chonnam National University Hwasun Hospital, Hwasun, Jeonnam, Korea. Electronic address: ujingogo@paran.com.
authors: Sun-Seog
authors: SS
authors: Kweon
mesh_terms: D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000453:epidemiology / Q000209:etiology*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009765:Obesity / Q000150:complications* / Q000235:genetics; D016017:Odds Ratio; D050177:Overweight / Q000150:complications / Q000235:genetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011379:Prognosis; D058118:Transcription Factor 7-Like 2 Protein / Q000235:genetics*
chemical_list: C544894:TCF7L2 protein, human; D058118:Transcription Factor 7-Like 2 Protein
keywords: Colorectal cancer; Diabetes; Obesity; Risk factor; TCF7L2