title: Nucleophilic Tetrafluoroethylation Employing in Situ Formed Organomagnesium Reagents.
abstract: Tetrafluoroalkyl bromides are metalated with equimolar iPrMgCl·LiCl (Turbo Grignard) to form organomagnesium compounds which are stable at low temperatures and react with various electrophiles (aldehydes, ketones, CO2, cyclic sulfate and sulfamidate, N-sulfonylimines, nitrone, chlorophosphate, nonaflyl azide) to afford novel functionalized tetrafluoroethylene-containing products. Ease of operation, excellent selectivity, high nucleophilicity, and enhanced stability of the reactive species together with a broad substrate scope comprise a highly attractive nucleophilic tetrafluoroethylation protocol affording unique synthetic building blocks.
authors: The Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences , Flemingovo náměstí 2, 166 10 Prague 6, Czech Republic.
authors: Alena
authors: A
authors: Budinská
authors: The Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences , Flemingovo náměstí 2, 166 10 Prague 6, Czech Republic.|Laboratory of Molecular Structure Characterization, Institute of Microbiology, Academy of Sciences of the Czech Republic , Vídeňská 1083, 142 20 Prague 4, Czech Republic.
authors: Jiří
authors: J
authors: Václavík
authors: CF Plus Chemicals s.r.o., Kamenice 771/34, 625 00 Brno, Czech Republic.
authors: Václav
authors: V
authors: Matoušek
authors: The Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences , Flemingovo náměstí 2, 166 10 Prague 6, Czech Republic.
authors: Petr
authors: P
authors: Beier