title: The role of RNA metabolism in neurological diseases.
abstract: Neurodegenerative disorders are commonly encountered in medical practices. Such diseases can lead to major morbidity and mortality among the affected individuals. The molecular pathogenesis of these disorders is not yet clear. Recent literature has revealed that mutations in RNA-binding proteins are a key cause of several human neuronal-based diseases. This review discusses the role of RNA metabolism in neurological diseases with specific emphasis on roles of RNA translation and microRNAs in neurodegeneration, RNA-mediated toxicity, repeat expansion diseases and RNA metabolism, molecular pathogenesis of amyotrophic lateral sclerosis and frontotemporal dementia, and neurobiology of survival motor neuron (SMN) and spinal muscular atrophy.
authors: Department of Neurosurgery, University of Calgary, Calgary, Alberta, Canada; Division of Neurosurgery, Department of Surgery, King Saud University, Riyadh, Saudi Arabia.
authors: A M
authors: AM
authors: Alaqeel
authors: College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.
authors: H
authors: H
authors: Abou Al-Shaar
authors: College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.
authors: R K
authors: RK
authors: Shariff
authors: Division of Neurosurgery, Department of Surgery, King Saud University, Riyadh, Saudi Arabia.
authors: A
authors: A
authors: Albakr
keywords: Amyotrophic lateral sclerosis; Frontotemporal dementia; RNA; Spinal muscular atrophy; Survival motor neuron (SMN)