title: Differences in Cortisol Awakening Response between Binge-Purging and Restrictive Patients with Anorexia Nervosa.
abstract: Malnutrition and childhood trauma were shown to affect in opposite way the cortisol awakening response (CAR) of patients with anorexia nervosa (AN). To assess the influence of binge-purging behaviour on the CAR of AN patients, we measured the CAR of restrictive AN (ANR) or binge-purging AN (ANBP) patients without history of childhood maltreatment. Seventeen ANBP women, 18 ANR women and 42 healthy women collected saliva samples at awakening and after 15, 30 and 60 min, and filled in the Eating Disorder Inventory-2 (EDI-2). ANR and ANBP patients exhibited a CAR significantly higher than healthy women. Moreover, the CAR of ANBP women was even higher than that of ANR women and positively correlated with the bulimia subitem scores of the EDI-2. Present findings show, for the first time, differences in the CAR between ANBP and ANR subtypes, which may suggest a possible connection between the HPA axis functioning and binge-purging. Copyright © 2016 John Wiley & Sons, Ltd and Eating Disorders Association.
authors: Department of Psychiatry, University of Naples SUN, Naples, Italy.
authors: Alessio Maria
authors: AM
authors: Monteleone
authors: Department of Psychiatry, University of Naples SUN, Naples, Italy.|Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', Section of Neurosciences, University of Salerno, Salerno, Italy.
authors: Palmiero
authors: P
authors: Monteleone
authors: Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', Section of Neurosciences, University of Salerno, Salerno, Italy.
authors: Francesca
authors: F
authors: Marciello
authors: Department of Psychiatry, University of Naples SUN, Naples, Italy.
authors: Francesca
authors: F
authors: Pellegrino
authors: Department of Neurosciences, Unit of Psychiatry, University of Florence, Florence, Italy.
authors: Giovanni
authors: G
authors: Castellini
authors: Department of Psychiatry, University of Naples SUN, Naples, Italy.
authors: Mario
authors: M
authors: Maj
mesh_terms: D000293:Adolescent; D000328:Adult; D000856:Anorexia Nervosa / Q000503:physiopathology*; D052018:Bulimia Nervosa / Q000503:physiopathology*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism*; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology*; D010913:Pituitary-Adrenal System / Q000502:physiology*; D055815:Young Adult
chemical_list: D006854:Hydrocortisone
keywords: anorexia nervosa; binge-purging; cortisol awakening response; stress