title: Mean platelet volume: a potential biomarker of the risk and prognosis of heart disease.
abstract: Platelets are essential for progression of atherosclerotic lesions, plaque destabilization, and thrombosis. They secrete and express many substances that are crucial mediators of coagulation, inflammation, and atherosclerosis. Mean platelet volume (MPV) is a precise measure of platelet size, and is routinely reported during complete blood count analysis. Emerging evidence supports the use of MPV as a biomarker predicting the risk of ischemic stroke in patients with atrial fibrillation, and as a guide for prescription of anticoagulation and rhythm-control therapy. In addition, MPV may predict the clinical outcome of percutaneous coronary intervention (PCI) in patients with coronary artery disease and indicate whether additional adjunctive therapy is needed to improve clinical outcomes. This review focuses on the current evidence that MPV may be a biomarker of the risk and prognosis of common heart diseases, particularly atrial fibrillation and coronary artery disease treated via PCI.
authors: Department of Internal Medicine, Chosun University School of Medicine, Gwangju, Korea.
authors: Dong-Hyun
authors: DH
authors: Choi
authors: Department of Laboratory Medicine, Chosun University School of Medicine, Gwangju, Korea.
authors: Seong-Ho
authors: SH
authors: Kang
authors: Department of Biochemistry and Molecular Biology, Chosun University School of Medicine, Gwangju, Korea.
authors: Heesang
authors: H
authors: Song
mesh_terms: D015415:Biomarkers / Q000097:blood; D001792:Blood Platelets / Q000378:metabolism* / Q000473:pathology; D018450:Disease Progression; D006331:Heart Diseases / Q000097:blood* / Q000175:diagnosis / Q000401:mortality / Q000628:therapy; D006801:Humans; D063847:Mean Platelet Volume; D015539:Platelet Activation; D011237:Predictive Value of Tests; D012307:Risk Factors; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers
keywords: Atrial fibrillation; Coronary artery disease; Ischemic stroke; Mean platelet volume; Percutaneous coronary intervention