title: Characterisation of Lesions after Stereotactic Radiosurgery for Brain Metastases: Impact of Delayed Contrast Magnetic Resonance Imaging.
abstract: OBJECTIVE
  To investigate if brain metastases and radiation injuries after stereotactic radiosurgery (SRS) have different signal intensity (SI) time courses up to 55 min after contrast agent application and if delayed contrast magnetic resonance imaging (MRI) contributes to improve diagnostic accuracy.
  
  
  METHODS
  Thirty-four consecutive patients treated with SRS for cerebral metastases were prospectively enrolled in the study. T1-weighted images were acquired on a 3-Tesla MR unit at three time points, at 2 (TP1), 15 (TP2) and 55 (TP3) min after administering contrast agent. A simultaneous, matched-pairs approach was used for region of interest analysis of the entire contrast-enhancing lesion (SI-e), the centre (SI-c), the border of the lesion (SI-b) and the adjacent non-contrast-enhancing tissue (SI-p). SIs of brain metastases and radiation injuries after SRS were compared using a two-level, linear, mixed-effects regression model.
  
  
  RESULTS
  In total, 41 lesions were analysed: 16 metastases and 25 radiation injuries. The SI time course of SI-e, SI-c and SI-b proved to be significantly different for both entities (P < 0.001) from TP2 to TP3. The SI of 39/41 lesions increased from TP1 to TP2 for the three parameters. Radiation injuries showed a further signal increase at least for SI-c from TP2 to TP3, whereas for all the three parameters SI decreased in all metastases.
  
  
  CONCLUSIONS
  Brain metastases and radiation injuries after SRS have a characteristic and statistically significantly different SI time course on sequential gadolinium enhancement MRI when late MR studies are included.
authors: Department of Neuroradiology, Friedrich-Schiller-University Jena, Jena, Germany; Institute of Neuroradiology, Johann-Wolfgang-Goethe University Frankfurt, Frankfurt am Main, Germany. Electronic address: sabine-m-wagner@gmx.de.
authors: S
authors: S
authors: Wagner
authors: Department of Diagnostic Radiology, Martin-Luther-University Halle-Wittenberg, Halle/Saale, Germany.
authors: H
authors: H
authors: Gufler
authors: Mathematical Institute, Justus-Liebig-University Giessen, Giessen, Germany.
authors: G
authors: G
authors: Eichner
authors: Institute of Neuroradiology, Johann-Wolfgang-Goethe University Frankfurt, Frankfurt am Main, Germany; Institute of Diagnostic and Interventional Neuroradiology, Hannover Medical School, Hannover, Germany.
authors: H
authors: H
authors: Lanfermann
mesh_terms: D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D003287:Contrast Media; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis / Q000000981:diagnostic imaging / Q000473:pathology*; D011832:Radiation Injuries / Q000175:diagnosis / Q000209:etiology / Q000473:pathology*; D016634:Radiosurgery / Q000009:adverse effects* / Q000379:methods
chemical_list: D003287:Contrast Media
keywords: Brain metastases; MRI; delayed contrast MRI; gadolinium-DTPA; radionecrosis; stereotactic radiosurgery