title: Impact of Ataxin-2 knock out on circadian locomotor behavior and PER immunoreaction in the SCN of mice.
abstract: In Drosophila melanogaster, Ataxin-2 is a crucial activator of Period and is involved in the control of circadian rhythms. However, in mammals the function of Ataxin-2 is unknown despite its involvement in the inherited neurogenerative disease Spinocerebellar Ataxia type 2 in humans. Therefore, we analyzed locomotor behavior of Atxn2-deficient mice and their WT littermates under entrained- and free-running conditions as well as after experimental jet lag. Furthermore, we compared the PER1 and PER2 immunoreaction (IR) in the SCN. Atxn2-/-mice showed an unstable rhythmicity of locomotor activity, but the level of PER1 and PER2 IR in the SCN did not differ between genotypes.
authors: a Dr. Senckenbergische Anatomie II, Fachbereich Medizin , Goethe-Universität Frankfurt , Frankfurt am Main , Germany.|b Dr. Senckenbergisches Chronomedizinisches Institut , Goethe-Universität Frankfurt , Frankfurt am Main , Germany.
authors: Martina
authors: M
authors: Pfeffer
authors: c Experimental Neurology, Department of Neurology , Goethe-Universität Frankfurt , Frankfurt am Main , Germany.
authors: Suzana
authors: S
authors: Gispert
authors: c Experimental Neurology, Department of Neurology , Goethe-Universität Frankfurt , Frankfurt am Main , Germany.
authors: Georg
authors: G
authors: Auburger
authors: a Dr. Senckenbergische Anatomie II, Fachbereich Medizin , Goethe-Universität Frankfurt , Frankfurt am Main , Germany.
authors: Helmut
authors: H
authors: Wicht
authors: a Dr. Senckenbergische Anatomie II, Fachbereich Medizin , Goethe-Universität Frankfurt , Frankfurt am Main , Germany.|b Dr. Senckenbergisches Chronomedizinisches Institut , Goethe-Universität Frankfurt , Frankfurt am Main , Germany.
authors: Horst-Werner
authors: HW
authors: Korf
mesh_terms: D000818:Animals; D000067698:Ataxin-2 / Q000235:genetics / Q000378:metabolism*; D002940:Circadian Rhythm / Q000235:genetics / Q000502:physiology*; D005786:Gene Expression Regulation / Q000502:physiology; D051379:Mice; D009043:Motor Activity / Q000235:genetics / Q000502:physiology*; D056950:Period Circadian Proteins / Q000235:genetics / Q000378:metabolism*; D013493:Suprachiasmatic Nucleus / Q000378:metabolism*
chemical_list: D000067698:Ataxin-2; C000593754:Atxn2 protein, mouse; C539023:Per1 protein, mouse; C513312:Per2 protein, mouse; D056950:Period Circadian Proteins
keywords: Endogenous clock; PER1; PER2; SCA2; spinocerebellar ataxia type 2