title: HDL as a Causal Factor in Atherosclerosis: Insights from Human Genetics.
abstract: High-density lipoprotein cholesterol (HDL-C) levels are inversely related to risk of atherosclerotic cardiovascular disease (ASCVD). However, the simplistic assumption that HDL-C levels directly and causally impact atherogenesis has been challenged in recent years. The purpose of this article is to review the current state of knowledge regarding genetically determined HDL-C levels and ASCVD risk and determine what insight these studies provide into the causal relationship between HDL and atherosclerosis.
authors: Department of Medicine, University of British Columbia, Vancouver, Canada. Liam.brunham@ubc.ca.|Centre for Heart Lung Innovation, Providence Health Care Research Institute, University of British Columbia, St. Paul's Hospital, Room 166-1081 Burrard Street, Vancouver, BC, V6Z 1Y6, Canada. Liam.brunham@ubc.ca.|Translational Laboratory in Genetic Medicine (TLGM), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore. Liam.brunham@ubc.ca.
authors: Liam R
authors: LR
authors: Brunham
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000235:genetics*; D014644:Genetic Variation; D005826:Genetics, Medical / Q000379:methods; D055106:Genome-Wide Association Study; D006801:Humans; D008075:Lipoproteins, HDL / Q000235:genetics*; D012306:Risk
chemical_list: D008075:Lipoproteins, HDL
keywords: Atherosclerosis; Genetics; HDL; Lipids; Lipoproteins