title: Postrehabilitation Functional Improvements in Patients With Inflammatory Myopathies: The Results of a Randomized Controlled Trial.
abstract: To evaluate the medium-term functional effect and the effect on quality of life of a standardized rehabilitation program in patients with inflammatory myopathies (IMs).
  
  
  
  A multicenter, randomized controlled trial.
  
  
  
  Four university hospitals.
  
  
  
  Patients (N=21) with polymyositis.
  
  
  
  The intervention group participated in a 4-week standardized, hospital-based rehabilitation program followed by a personalized, self-managed, home-based rehabilitation program. The control group received physiotherapy on an outpatient basis. Study participants were evaluated at inclusion, at the end of the rehabilitation program (1mo), and then at 6 and 12 months.
  
  
  
  The primary efficacy criterion was the Health Assessment Questionnaire Disability Index (HAQ-DI), and the secondary criteria were quality of life (according to the Medical Outcomes Study 36-Item Short-Form Health Survey [SF-36] questionnaire), muscle performance (isokinetic strength, Motor Function Measure, and Kendall Manual Muscle Test), gait, pain, fatigue, and biomarkers of tolerance and disease activity.
  
  
  
  At 12 months, the mean ± SD HAQ-DI was significantly lower in the intervention group than in the control group (.64±.53 vs 1.36±1.02; P=.026). The intervention group also had better scores than the control group for some quality-of-life dimensions (SF-36 General Health: 53.44±8.73 vs 36.57±22.10, respectively; P=.038; SF-36 Role Physical: 63.89±43.50 vs 17.86±37.40, respectively; P=.023) and pain levels (5.0±10.61 vs 33.38±35.68, respectively; P=.04) at 12 months. The program was well tolerated by all the participants.
  
  
  
  In patients with IMs, the combination of a 4-week standardized rehabilitation program and a personalized, home-based, self-managed rehabilitation program was well tolerated and had a positive medium-term functional effect.
authors: Rehabilitation Unit, Lille University Hospital, Lille, France; Research Unit 7369, Physical Activity, Muscle Health, University of Lille, Lille, France. Electronic address: vincent.tiffreau@chru-lille.fr.
authors: Vincent
authors: V
authors: Tiffreau
authors: Rehabilitation Unit, Rheumatology Department, Hôpital Cochin, Assistance Publique, Hopitaux de Paris, National Institute for Health and Medical Research UMR-S 1124, Paris, France.
authors: François
authors: F
authors: Rannou
authors: Rehabilitation Unit, Lille University Hospital, Lille, France.
authors: François
authors: F
authors: Kopciuch
authors: U995 Lille Inflammation Research International Center, Lille, France; Internal Medicine and Clinical Immunology Department, Systemic Sclerosis and Rare Autoimmune Diseases Reference Center, Lille, France; Immune-Mediated Inflammatory Diseases and Targeted Therapies (IMMINeNT), Lille, France.
authors: Eric
authors: E
authors: Hachulla
authors: National Institute for Health and Medical Research, U1016, Institut Cochin, CNRS, UMR8104, University Paris-Descartes, Sorbonne-Paris-Cité, Paris, France.
authors: Luc
authors: L
authors: Mouthon
authors: Assistance Publique, Hopitaux de Paris, Neurorehabilitation Centre for Neuromuscular Disorders, Rothschild Hospital, Université Pierre et Marie Curie Paris 6, Paris, France.
authors: Philippe
authors: P
authors: Thoumie
authors: Faculty of Medicine, National Institute for Health and Medical Research UMR_S1109, LabEx Transplantex, Immunology and Hematology Research Center, University of Strasbourg, Strasbourg, France.
authors: Jean
authors: J
authors: Sibilia
authors: Research Unit 2694, Public Health, Epidemiology and Quality of Care, Centre Hospitalier Régional, University of Lille, Lille, France.
authors: Elodie
authors: E
authors: Drumez
authors: Rehabilitation Unit, Lille University Hospital, Lille, France; Research Unit 7369, Physical Activity, Muscle Health, University of Lille, Lille, France.
authors: André
authors: A
authors: Thevenon
mesh_terms: D000328:Adult; D015415:Biomarkers; D000072599:Cardiorespiratory Fitness / Q000502:physiology; D004185:Disability Evaluation; D005081:Exercise Therapy; D005260:Female; D006304:Health Status; D006785:Hospitals, University; D006801:Humans; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000502:physiology; D009220:Myositis / Q000534:rehabilitation*; D010146:Pain / Q000534:rehabilitation*; D026741:Physical Therapy Modalities; D011788:Quality of Life; D016059:Range of Motion, Articular
chemical_list: D015415:Biomarkers
keywords: Myositis; Quality of life; Rehabilitation