title: HDL Cholesterol Level Is Associated with Contrast Induced Acute Kidney Injury in Chronic Kidney Disease Patients Undergoing PCI.
abstract: Chronic kidney disease (CKD) is a significant risk factor for contrast induced acute kidney injury (CI-AKI) after percutaneous coronary intervention (PCI). This study included 1592 CKD patients extracted from a prospective multicenter, all comer-based registry of patients undergoing PCI. In multivariate logistic analysis for CI-AKI development, a significant linear trend was observed between the quartiles of HDL-C (quartile 1 vs. 2: odds ratio [OR], 0.716; 95% confidence interval [CI], 0.421-1.219; quartile 1 vs. 3: OR, 0.534; 95% CI, 0.301-0.947; quartile 1 vs. 4: OR, 0.173; 95% CI, 0.079-0.377; P for trend < 0.001). HDL-C quartiles were also negatively correlated with the incidence of CI-AKI; 19.0%, 12.1%, 8.7%, and 3.7% for quartile 1(Q1) (<34 mg/dL), Q2 (34-40 mg/dL), Q3 (40-48 mg/dL), and Q4 (>48 mg/dL) respectively (P < 0.001 overall and for the trend). Multivariate Cox regression analysis for the long term mortality, the highest HDL-C quartile was associated with decreased mortality compared with the lowest HDL-C quartile (hazard ratio [HR] 0.516, 95% CI, 0.320-0.832, P = 0.007). Our study suggests more intensive strategies should be considered for preventing CI-AKI in CKD patients with low serum HDL-C level who is planned for PCI.
authors: Nephrology Division, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Republic of Korea.
authors: Hoon Suk
authors: HS
authors: Park
authors: Cardiology Division, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Republic of Korea.
authors: Chan Joon
authors: CJ
authors: Kim
authors: Cardiology Division, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Republic of Korea.
authors: Byung-Hee
authors: BH
authors: Hwang
authors: Cardiology Division, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Republic of Korea.
authors: Tae-Hoon
authors: TH
authors: Kim
authors: Cardiology Division, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Republic of Korea.
authors: Yoon Seok
authors: YS
authors: Koh
authors: Cardiology Division, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Republic of Korea.
authors: Hun-Jun
authors: HJ
authors: Park
authors: Cardiology Division, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Republic of Korea.
authors: Sung-Ho
authors: SH
authors: Her
authors: Cardiology Division, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Republic of Korea.
authors: Sung Won
authors: SW
authors: Jang
authors: Cardiology Division, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Republic of Korea.
authors: Chul-Soo
authors: CS
authors: Park
authors: Cardiology Division, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Republic of Korea.
authors: Jong Min
authors: JM
authors: Lee
authors: Cardiology Division, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Republic of Korea.
authors: Hee-Yeol
authors: HY
authors: Kim
authors: Cardiology Division, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Republic of Korea.
authors: Doo Soo
authors: DS
authors: Jeon
authors: Cardiology Division, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Republic of Korea.
authors: Pum-Joon
authors: PJ
authors: Kim
authors: Cardiology Division, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Republic of Korea.
authors: Ki-Dong
authors: KD
authors: Yoo
authors: Cardiology Division, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Republic of Korea.
authors: Kiyuk
authors: K
authors: Chang
authors: Nephrology Division, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Republic of Korea.
authors: Dong Chan
authors: DC
authors: Jin
authors: Cardiology Division, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Republic of Korea.
authors: Ki-Bae
authors: KB
authors: Seung
mesh_terms: D058186:Acute Kidney Injury / Q000097:blood* / Q000139:chemically induced*; D000368:Aged; D008076:Cholesterol, HDL / Q000097:blood*; D003287:Contrast Media / Q000009:adverse effects*; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects*; D016016:Proportional Hazards Models; D011446:Prospective Studies; D051436:Renal Insufficiency, Chronic / Q000097:blood* / Q000601:surgery; D012307:Risk Factors
chemical_list: D008076:Cholesterol, HDL; D003287:Contrast Media