title: Shared mechanisms in physiological and pathological nucleoplasmic reticulum formation.
abstract: The mammalian nuclear envelope (NE) can develop complex dynamic membrane-bounded invaginations in response to both physiological and pathological stimuli. Since the formation of these nucleoplasmic reticulum (NR) structures can occur during interphase, without mitotic NE breakdown and reassembly, some other mechanism must drive their development. Here we consider models for deformation of the interphase NE, together with the evidence for their potential roles in NR formation.
authors: a Sir William Dunn School of Pathology , University of Oxford , Oxford , UK.
authors: Marek Mateusz
authors: MM
authors: Drozdz
authors: a Sir William Dunn School of Pathology , University of Oxford , Oxford , UK.
authors: David John
authors: DJ
authors: Vaux
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D006801:Humans; D007399:Interphase; D008563:Membrane Lipids / Q000378:metabolism; D008565:Membrane Proteins / Q000378:metabolism; D009685:Nuclear Envelope / Q000737:chemistry / Q000378:metabolism*
chemical_list: D008563:Membrane Lipids; D008565:Membrane Proteins
keywords: NE; NR; chromosome territories; cytoskeleton; gene expression; membrane curvature; nuclear envelope; nucleoplasmic reticulum