title: Predictive factors related to shoulder joint destruction in rheumatoid arthritis patients treated with biologics: A prospective study.
abstract: OBJECTIVE
  The aim of this study was to assess the risk factors for shoulder joint destruction in rheumatoid arthritis (RA) patients treated with biologics.
  
  
  METHODS
  Thirty shoulders of 29 patients with RA were assessed using 18F-fluorodeoxyglucose positron emission tomography (PET) and magnetic resonance imaging (MRI) before starting biologics and 6 months later. The mean age (range) was 54 (18-72) years, and the mean disease duration was 7 (0.8-30) years. The radiographic findings were assessed at baseline and 3 years later. The inflammation markers and RA disease activity were also assessed. These parameters were compared between the progression of joint destruction group and the no progression group.
  
  
  RESULTS
  The SUVmax on PET, the rate of synovitis, and the rate of rotator cuff tear on MRI before biologic treatment were significantly higher in the progression of joint destruction group. SUVmax and synovitis on MRI after 6 months were also significantly higher in the progression of joint destruction group. On logistic regression analysis, the SUV at baseline of the shoulder joint was the main risk factor for joint destruction.
  
  
  CONCLUSIONS
  The detection of synovitis by imaging was more important than disease activity and inflammation markers for assessing the progression of shoulder joint destruction.
authors: a Department of Orthopaedic Surgery , Gunma University Graduate School of Medicine , Maebashi , Gunma , Japan.
authors: Yukio
authors: Y
authors: Yonemoto
authors: a Department of Orthopaedic Surgery , Gunma University Graduate School of Medicine , Maebashi , Gunma , Japan.
authors: Koichi
authors: K
authors: Okamura
authors: b Department of Physical Therapy, Faculty of Health Care , Takasaki University of Health and Welfare , Takasaki , Gunma , Japan.
authors: Tsutomu
authors: T
authors: Kobayashi
authors: c Department of Orthopaedic Surgery , Inoue Hospital , Takasaki , Gunma , Japan , and.
authors: Tetsuya
authors: T
authors: Kaneko
authors: a Department of Orthopaedic Surgery , Gunma University Graduate School of Medicine , Maebashi , Gunma , Japan.
authors: Chisa
authors: C
authors: Okura
authors: a Department of Orthopaedic Surgery , Gunma University Graduate School of Medicine , Maebashi , Gunma , Japan.
authors: Takahito
authors: T
authors: Suto
authors: a Department of Orthopaedic Surgery , Gunma University Graduate School of Medicine , Maebashi , Gunma , Japan.
authors: Masahiro
authors: M
authors: Tachibana
authors: d Department of Diagnostic Radiology and Nuclear Medicine , Gunma University Graduate School of Medicine , Maebashi , Gunma , Japan.
authors: Yoshito
authors: Y
authors: Tsushima
authors: a Department of Orthopaedic Surgery , Gunma University Graduate School of Medicine , Maebashi , Gunma , Japan.
authors: Kenji
authors: K
authors: Takagishi
mesh_terms: D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000473:pathology; D001688:Biological Products / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D011446:Prospective Studies; D012785:Shoulder Joint / Q000000981:diagnostic imaging / Q000473:pathology*; D013585:Synovitis / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000473:pathology
chemical_list: D001688:Biological Products
keywords: Biologics; Magnetic resonance imaging; Positron emission tomography; Rheumatoid arthritis; Shoulder