title: Three-minute synthesis of sp3nanocrystalline carbon dots as non-toxic fluorescent platforms for intracellular delivery.
abstract: A one-pot, three-minute, gram-scale synthesis of novel sp3-nanocrystalline, water-soluble, and fluorescent carbon dots (FCDs), from simple and cheap sugar starting materials is described. Mechanism studies showed that NH2-FCD formation proceeds via a crucial imine intermediate derived from reaction between a sugar hemiacetal and an amine. Moreover, we successfully demonstrate the utility of lactose functionalized FCDots (Lac-FCDots) as non-toxic fluorescent intracellular delivery vehicles.
authors: School of Chemistry, University of Bristol, Cantock's Close, Bristol, BS8 1TS, UK. m.c.galan@bristol.ac.uk.
authors: Stephen A
authors: SA
authors: Hill
authors: School of Chemistry, University of Bristol, Cantock's Close, Bristol, BS8 1TS, UK. m.c.galan@bristol.ac.uk.
authors: David
authors: D
authors: Benito-Alifonso
authors: Cardiff Catalysis Institute, School of Chemistry, Cardiff University, Park Place, Cardiff, CF10 3AT, UK.
authors: David J
authors: DJ
authors: Morgan
authors: School of Chemistry, University of Bristol, Cantock's Close, Bristol, BS8 1TS, UK. m.c.galan@bristol.ac.uk.
authors: Sean A
authors: SA
authors: Davis
authors: School of Chemistry, University of Bristol, Cantock's Close, Bristol, BS8 1TS, UK. m.c.galan@bristol.ac.uk.
authors: Monica
authors: M
authors: Berry
authors: School of Chemistry, University of Bristol, Cantock's Close, Bristol, BS8 1TS, UK. m.c.galan@bristol.ac.uk.
authors: M Carmen
authors: http://orcid.org/0000-0001-7307-2871
authors: MC
authors: Galan
mesh_terms: D000588:Amines; D002241:Carbohydrates / Q000737:chemistry*; D002244:Carbon; D004337:Drug Carriers / Q000737:chemistry*; D005453:Fluorescence; D045663:Quantum Dots
chemical_list: D000588:Amines; D002241:Carbohydrates; D004337:Drug Carriers; D002244:Carbon