title: Achieving regio- and stereo-control in the fluorination of aziridines under acidic conditions.
abstract: We developed an efficient fluorination protocol that converts easily accessible aziridines into β-fluoroamines, which are important motifs in biologically active molecules. In contrast with traditional fluorination approaches, DMPU-HF has shown both higher reactivity and regioselectivity and good functional group tolerance; thus, a wide scope of β-fluoroamines can now be accessed conveniently. The stereochemical behavior of the ring opening depends on the substitution pattern of the aziridine substrate.
authors: Department of Chemistry, University of Louisville, Louisville, KY 40292, USA. gb.hammond@louisville.edu.
authors: Otome E
authors: OE
authors: Okoromoba
authors: Department of Chemistry, University of Louisville, Louisville, KY 40292, USA. gb.hammond@louisville.edu.
authors: Zhou
authors: Z
authors: Li
authors: Department of Chemistry, University of Louisville, Louisville, KY 40292, USA. gb.hammond@louisville.edu.
authors: Nicole
authors: N
authors: Robertson
authors: Department of Chemistry, University of Louisville, Louisville, KY 40292, USA. gb.hammond@louisville.edu.
authors: Mark S
authors: MS
authors: Mashuta
authors: Institute of Chemistry, University of Campinas, São Paulo 13083-970, Brazil. tormena@iqm.unicamp.br.
authors: Uenifer R
authors: UR
authors: Couto
authors: Institute of Chemistry, University of Campinas, São Paulo 13083-970, Brazil. tormena@iqm.unicamp.br.
authors: Cláudio F
authors: http://orcid.org/0000-0002-1508-0694
authors: CF
authors: Tormena
authors: College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, 2999 North Renmin Lu, Shanghai 201620, China. bo.xu@dhu.edu.cn.
authors: Bo
authors: B
authors: Xu
authors: Department of Chemistry, University of Louisville, Louisville, KY 40292, USA. gb.hammond@louisville.edu.
authors: Gerald B
authors: GB
authors: Hammond