title: Scalable Synthesis of Enantiopure Bis-3,4-diazaphospholane Ligands for Asymmetric Catalysis.
abstract: An optimized route to enantiopure tetra-carboxylic acid and tetra-carboxamide bis(diazaphospholane) ligands that obviates chromatographic purification is presented. This synthesis, which is demonstrated on 15 and 100 g scales, features a scalable classical resolution of tetra-carboxylic acid enantiomers with recycling of the resolving agent. When paired with a rhodium metal center, these bis(diazaphospholane) ligands are highly active and selective in asymmetric hydroformylation applications.
authors: Department of Chemistry, University of Wisconsin-Madison , Madison, Wisconsin 53706, United States.
authors: Bradley R
authors: BR
authors: Jones
authors: Department of Chemistry, University of Wisconsin-Madison , Madison, Wisconsin 53706, United States.
authors: M Leigh
authors: ML
authors: Abrams
authors: Department of Chemistry, University of Wisconsin-Madison , Madison, Wisconsin 53706, United States.
authors: Clark R
authors: CR
authors: Landis
authors: Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States.
authors: Scott A
authors: SA
authors: May
authors: Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States.
authors: Alison N
authors: AN
authors: Campbell
authors: Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States.
authors: Joseph R
authors: JR
authors: Martinelli
authors: Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States.
authors: Joel R
authors: JR
authors: Calvin