title: Cardiac safety of systemic therapy in breast cancer patients with high risk of atherosclerosis complications.
abstract: OBJECTIVE
  This study was designed to verify the efficacy of breast cancer treatment and its cardiac toxicity in population with significant cardiac comorbidities.
  
  
  METHODS
  Prospective observational study was conducted in 48 patients.
  
  
  RESULTS
  The increase and dependence of echocardiographic parameter early/late were observed on hemoglobin level in all patients, and white blood cells and cholesterol in patients with diabetic were reported. Patients undergo left ventricle diameter change on treatment.
  
  
  CONCLUSIONS
  Use of potentially cardiotoxic chemo regimens in breast cancer patients with cardiac comorbidities, with optimized cardiac therapy accordingly can save patients from development of early myocardial dysfunction induced by chemotherapy - limiting factor to minimize the risk is optimization of lipid level, red blood cell count and platelets count.
authors: Department of Oncology, Military Institute of Medicine, Warsaw, Poland.|Department of Internal Medicine & Oncology, 108th Military Hospital with Outpatient Clinic, Elk, Poland.|Department of Internal Medicine, Cardiology & Hypertensiology, L Rydygier Providential Hospital, Suwalki, Poland.|Department of Nephrology & Dialysis Centre, L Rydygier Providential Hospital, Suwalki, Poland.
authors: Arthur
authors: A
authors: Matyszewski
authors: Department of Oncology, Military Institute of Medicine, Warsaw, Poland.
authors: Anna M
authors: AM
authors: Czarnecka
authors: Department of Cardiology, Pomeranian Medical University, Szczecin, Poland.
authors: Paweł
authors: P
authors: Stachowiak
authors: Department of Cardiology, Medical University of Lodz, Lodz, Poland.
authors: Marta
authors: M
authors: Nowakowska
authors: Department of Cardiology, Pomeranian Medical University, Szczecin, Poland.
authors: Zdzisława
authors: Z
authors: Kornacewicz-Jach
authors: Department of Cardiology, Medical University of Lodz, Lodz, Poland.
authors: Jarosław D
authors: JD
authors: Kasprzak
authors: Department of Oncology, Military Institute of Medicine, Warsaw, Poland.
authors: Cezary
authors: C
authors: Szczylik
mesh_terms: D000368:Aged; D000792:Angiography; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D050197:Atherosclerosis / Q000150:complications*; D001943:Breast Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy*; D066126:Cardiotoxicity / Q000209:etiology; D003131:Combined Modality Therapy; D003324:Coronary Artery Disease / Q000150:complications / Q000175:diagnosis; D003920:Diabetes Mellitus; D004452:Echocardiography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D016896:Treatment Outcome
keywords: anthracyclines; atherosclerosis; breast cancer; cardioprotection; cardiotoxicity; chemotherapy-related cardiac dysfunction; coronary disease; heart failure; taxanes; trastuzumab