title: Features of oral, pharyngeal, and laryngeal lesions in bullous pemphigoid.
abstract: Bullous pemphigoid is an autoimmune bullous disease characterized by skin lesions, with or without oral lesions. The occurrence of pharyngolaryngeal lesions is very rare in affected patients. We conducted a study to investigate the characteristics of oral and pharyngolaryngeal lesions in bullous pemphigoid. Our study population was made up of 6 consecutively presenting outpatients-2 men and 4 women, aged 40 to 83 years (mean: 68.2)-who had been referred to our department over an 11-year period. Presenting symptoms included sore throat in all 6 patients and oral pain in 3. The sites of mucosal lesions included the soft palate, epiglottis, gingiva, hypopharynx, tongue, nasal cavity, and buccal mucosa. These lesions appeared as erosions, erosions with white coating, erythematous patches, and/or blisters. Mucosal lesions preceded skin lesions in 2 patients, appeared after skin lesions in 1 patient, and appeared simultaneously with skin lesions in 3 patients. We conclude that bullous pemphigoid sometimes involves the mucosa, such as that of the laryngopharynx and the oral cavity, and it can manifest as skin lesions. In the differential diagnosis of refractory pharyngolaryngeal lesions, bullous pemphigoid should be considered.
authors: Department of Otolaryngology, Saitama Medical Center, Saitama Medical University, 1981 Kamoda, Kawagoe-shi, Saitama 350-8550, Japan. m-ohki@umin.ac.jp.
authors: Masafumi
authors: M
authors: Ohki
authors: Shigeru
authors: S
authors: Kikuchi
authors: Atsushi
authors: A
authors: Ohata
authors: Yuka
authors: Y
authors: Baba
authors: Junichi
authors: J
authors: Ishikawa
authors: Hirohito
authors: H
authors: Sugimoto
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001768:Blister / Q000209:etiology / Q000473:pathology; D005260:Female; D006801:Humans; D007818:Laryngeal Diseases / Q000209:etiology / Q000473:pathology*; D007820:Laryngeal Mucosa / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009059:Mouth Diseases / Q000209:etiology / Q000473:pathology*; D009061:Mouth Mucosa / Q000473:pathology; D010391:Pemphigoid, Bullous / Q000150:complications* / Q000473:pathology; D010608:Pharyngeal Diseases / Q000209:etiology / Q000473:pathology*; D012189:Retrospective Studies