title: Genetic variability of CYP2C9*2 and CYP2C9*3 in seven indigenous groups from Mexico.
abstract: OBJECTIVE
  CYP2C9 is one of the major drug metabolizing enzymes, however, little is known about polymorphisms in CYP2C9 gene and pharmacological implications in Mexican indigenous populations. Thus, frequencies of CYP2C9*2 and CYP2C9*3 alleles were evaluated in indigenous groups located in northwest (Cora), center (Mazahua and Teenek), south (Chatino and Mixteco) and southeast (Chontal and Maya) regions Mexico.
  
  
  METHODS
  Allelic discrimination was performed by real-time PCR.
  
  
  RESULTS
  CYP2C9*2 allele was found only in Chontal and Maya groups, despite the low contribution of Caucasian component in these populations. CYP2C9*3 allele was present in all populations except in Mazahua, showing a wide genetic variability in the studied populations. Interestingly, we found significant differences between indigenous groups in CYP2C9*3 allele, even in groups located at the same region and belonging to the same linguistic family.
  
  
  CONCLUSIONS
  These results contribute to laying the pharmacogenetic bases in Mexico, in addition to improving treatment, taking into account the genetic interethnic differences.
authors: Unidad de Genómica de Poblaciones Aplicada a la Salud, Facultad de Química, Universidad Nacional Autónoma de México -Instituto Nacional de Medicina Genómica.
authors: Katy
authors: K
authors: Sánchez-Pozos
authors: Unidad de Genómica de Poblaciones Aplicada a la Salud, Facultad de Química, Universidad Nacional Autónoma de México -Instituto Nacional de Medicina Genómica.
authors: Carolina
authors: C
authors: Rivera-Santiago
authors: Unidad de Genómica de Poblaciones Aplicada a la Salud, Facultad de Química, Universidad Nacional Autónoma de México -Instituto Nacional de Medicina Genómica.
authors: María Helena
authors: MH
authors: García-Rodríguez
authors: Laboratorio de Endocrinología Molecular, Hospital Juárez de México.
authors: María Guadalupe
authors: MG
authors: Ortiz-López
authors: Laboratorio de Diabetes, Facultad de Química, Unidad Académica de, Ciencias y Tecnología de la UNAM en Yucatán (PC&TY).
authors: Barbara Itzel
authors: BI
authors: Peña-Espinoza
authors: Unidad de Genómica de Poblaciones Aplicada a la Salud, Facultad de Química, Universidad Nacional Autónoma de México -Instituto Nacional de Medicina Genómica.
authors: María de Los Ángeles
authors: MLÁ
authors: Granados-Silvestre
authors: Centro de Investigación Clínica, Área de Salud de Badajoz, SES, Servicio Extremeño de Salud, Hospital Universitario Infanta Cristina, Badajoz, España.
authors: Adrian
authors: A
authors: Llerena
authors: Unidad de Genómica de Poblaciones Aplicada a la Salud, Facultad de Química, Universidad Nacional Autónoma de México -Instituto Nacional de Medicina Genómica.
authors: Marta
authors: M
authors: Menjívar
keywords: CYP2C9; Mexican indigenous; allele frequency; hypoglycemic therapy; pharmacogenetics; polymorphism