title: Oncogenic γ Herpesviruses EBV and HHV8 in Kidney Transplantation.
abstract: Epstein-Barr virus (EBV) and human herpesvirus-8 (HHV-8) are γ herpesviruses associated with post-transplant malignancies in kidney transplant recipients. EBV is associated with post-transplantation lymphoproliferative disorder (PTLD), with increased risk in EBV-seronegative patients on intensified immunosuppression. Human herpesvirus-8 is associated with Kaposi's sarcoma (KS), with an increased risk in certain patient populations. Diagnosis of PTLD and KS relies on tissue biopsy. The mainstay of therapy for both PTLD and Kaposi's sarcoma is a reduction of immunosuppression, and in the case of PTLD, consideration of rituximab. Chemotherapy, radiation therapy, or surgery is provided for disseminated or recalcitrant disease. The prognoses vary depending on the type of malignancy identified and stage of disease.
authors: Department of Medicine, University of Texas Southwestern Medical Center, Dallas, TX. Electronic address: jade.le@utsouthwestern.edu.
authors: Jade
authors: J
authors: Le
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D000074322:Antineoplastic Agents, Immunological / Q000627:therapeutic use; D020031:Epstein-Barr Virus Infections / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D006084:Graft Rejection / Q000517:prevention & control*; D006566:Herpesviridae Infections / Q000139:chemically induced / Q000175:diagnosis / Q000628:therapy / Q000821:virology; D004854:Herpesvirus 4, Human; D019288:Herpesvirus 8, Human; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D007676:Kidney Failure, Chronic / Q000601:surgery*; D016030:Kidney Transplantation; D008232:Lymphoproliferative Disorders / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy / Q000821:virology; D011878:Radiotherapy; D000069283:Rituximab / Q000627:therapeutic use; D012514:Sarcoma, Kaposi / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy / Q000821:virology; D013514:Surgical Procedures, Operative
chemical_list: D000970:Antineoplastic Agents; D000074322:Antineoplastic Agents, Immunological; D007166:Immunosuppressive Agents; D000069283:Rituximab
keywords: Epstein-Barr virus; HHV-8; Kaposi’s sarcoma; post-transplant lymphoproliferative disorder