title: Cognitive and anatomical correlates of anosognosia in amnestic mild cognitive impairment and early-stage Alzheimer's disease.
abstract: Anosognosia is a common feature in Alzheimer's disease (AD). The brain substrates of anosognosia are not fully understood, and less is known about the cognitive substrates of anosognosia in prodromal and early stages of AD.
  
  
  
  Fourty-seven patients with amnestic-type mild cognitive impairment (aMCI) (n = 26) and early-stage AD (n = 21) were included, and Clinical Insight Rating Scale and Anosognosia Questionnaire for Dementia (AQ-D) were used to assess anosognosia. A detailed neuropsychological battery was administered; each patient underwent a structural magnetic resonance imaging (MRI). Correlation between anosognosia and performance in individual cognitive domains as well as correlation between anosognosia and cortical thickness values in regions of interest were assessed.
  
  
  
  Performance of the anosognosic patients in Digit Ordering Test (DOT), Digit Span Backwards, and Clock Drawing Test (CDT) was significantly worse compared to non-anosognosic patients in the total study population and in the aMCI subgroup but not in AD group. AQ-D scores negatively correlated with Mini-Mental State Examination (MMSE), California Verbal Learning Test (CVLT), Digit Span Backwards and CDT scores in total group and MMSE, CVLT, DOT, and Digit Span Backwards scores in the aMCI group. No significant correlations were found between cortical thickness measurements and AQ-D scores in any of the patient populations.
  
  
  
  Anosognosia was associated with episodic memory, working memory, and executive functions in the total population and aMCI group, but no association was found in early-stage AD patients. Anosognosia in the early stages of AD may be related with non-structural changes such as hypoconnectivity rather than structural changes.
authors: Department of Neurology,Istanbul Faculty of Medicine,Istanbul University,Istanbul,Turkey.
authors: Gulben
authors: G
authors: Senturk
authors: Department of Neurology,Istanbul Faculty of Medicine,Istanbul University,Istanbul,Turkey.
authors: Basar
authors: B
authors: Bilgic
authors: Department of Cognitive,Linguistic and Psychological Sciences,Brown University,Providence,USA.
authors: Ali Bilgin
authors: AB
authors: Arslan
authors: Hulusi Behcet Life Sciences Research Center,Istanbul University,Istanbul,Turkey.
authors: Ali
authors: 0000-0002-6588-3479
authors: A
authors: Bayram
authors: Department of Neurology,Istanbul Faculty of Medicine,Istanbul University,Istanbul,Turkey.
authors: Hasmet
authors: H
authors: Hanagasi
authors: Department of Neurology,Istanbul Faculty of Medicine,Istanbul University,Istanbul,Turkey.
authors: Hakan
authors: H
authors: Gurvit
authors: Department of Neurology,Istanbul Faculty of Medicine,Istanbul University,Istanbul,Turkey.
authors: Murat
authors: M
authors: Emre
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000377:Agnosia / Q000523:psychology*; D000544:Alzheimer Disease / Q000150:complications / Q000523:psychology*; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000473:pathology*; D003071:Cognition; D060825:Cognitive Dysfunction / Q000150:complications / Q000523:psychology*; D056344:Executive Function; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D061212:Memory, Episodic; D008875:Middle Aged; D009483:Neuropsychological Tests; D009929:Organ Size; D011569:Psychiatric Status Rating Scales; D014421:Turkey
keywords: Alzheimer's disease; mild cognitive impairment