title: Serum uromodulin predicts graft failure in renal transplant recipients.
abstract: OBJECTIVE
  Test the ability of serum uromodulin concentrations 1-3 months after renal transplantation to predict all-cause mortality (ACM) and graft loss (GL) in 91 patients.
  
  
  RESULTS
  uromodulin predicted GL equivalently to the other markers studied: the risk for GL was reduced by 0.21 per one standard deviation (SD) increase (cystatin C: hazard ratio [HR] 4.57, creatinine: HR 4.53, blood-urea-nitrogen [BUN]: HR 2.50, estimated glomerular filtration rate [eGFR]: HR 0.10). In receiver-operating-characteristic (ROC) analysis, uromodulin predicted GL with an area-under-the curve of 0.782 at an optimal cut-off (OCO) of 24.0 ng/ml with a sensitivity of 90.0% and a specificity of 70.2%.
  
  
  CONCLUSIONS
  Serum uromodulin predicted GL equivalently compared to conventional biomarkers of glomerular filtration.
authors: a Department of Nephrology, Klinikum rechts der Isar , Technische Universität , München , Germany.
authors: Dominik
authors: D
authors: Steubl
authors: b Research&Development Department, Euroimmun Medizinische Labordiagnostika AG , Lübeck , Germany.
authors: Matthias
authors: M
authors: Block
authors: b Research&Development Department, Euroimmun Medizinische Labordiagnostika AG , Lübeck , Germany.
authors: Victor
authors: V
authors: Herbst
authors: b Research&Development Department, Euroimmun Medizinische Labordiagnostika AG , Lübeck , Germany.
authors: Wolfgang
authors: W
authors: Schlumberger
authors: c Institute of Laboratory Medicine and Pathobiochemistry , Universitätsklinikum Marburg, Philipps-Universität Marburg , Marburg , Germany.
authors: Andreas
authors: A
authors: Nockher
authors: a Department of Nephrology, Klinikum rechts der Isar , Technische Universität , München , Germany.
authors: Susanne
authors: S
authors: Angermann
authors: a Department of Nephrology, Klinikum rechts der Isar , Technische Universität , München , Germany.
authors: Christoph
authors: C
authors: Schmaderer
authors: a Department of Nephrology, Klinikum rechts der Isar , Technische Universität , München , Germany.
authors: Uwe
authors: U
authors: Heemann
authors: a Department of Nephrology, Klinikum rechts der Isar , Technische Universität , München , Germany.
authors: Lutz
authors: L
authors: Renders
authors: d Department of Nephrology and Clinical Immunology, Klinikum München-Harlaching , Teaching Hospital of the Ludwig-Maximilian-Universität , München , Germany.
authors: Jürgen
authors: J
authors: Scherberich
mesh_terms: D015415:Biomarkers / Q000097:blood; D005919:Glomerular Filtration Rate; D006084:Graft Rejection / Q000097:blood / Q000175:diagnosis*; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects* / Q000401:mortality; D011237:Predictive Value of Tests; D012372:ROC Curve; D012680:Sensitivity and Specificity; D058949:Uromodulin / Q000097:blood*
chemical_list: D015415:Biomarkers; D058949:Uromodulin
keywords: Biomarker; Tamm–Horsfall protein; cystatin C; eGFR; graft failure; kidney transplantation; proteinuria; uromodulin