title: Monocyte/Macrophage and TNFα-induced adipose related protein (TIARP) in rheumatoid arthritis.
abstract: In the pathogenesis of rheumatoid arthritis (RA), TNFα and IL-6 are proved to be crucial cytokines. Monocyte and macrophage are thought to produce these cytokines, as well as the source of cells becoming osteoclast in RA. In this review, I will discuss the role of monocyte/macrophage and the recent topic of negative regulator of arthritis such as TNFα-induced adipose related protein in RA.
authors: Department of Internal Medicine, Faculty of Medicine, University of Tsukuba.
authors: Isao
authors: I
authors: Matsumoto
mesh_terms: D000818:Animals; D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D015850:Interleukin-6 / Q000096:biosynthesis; D008264:Macrophages / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism / Q000502:physiology*; D051379:Mice; D058990:Molecular Targeted Therapy; D009000:Monocytes / Q000378:metabolism*; D010010:Osteoclasts; D010088:Oxidoreductases / Q000378:metabolism / Q000502:physiology*; D000072598:Tumor Necrosis Factor alpha-Induced Protein 3 / Q000502:physiology; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis*
chemical_list: D015850:Interleukin-6; D008565:Membrane Proteins; D014409:Tumor Necrosis Factor-alpha; D010088:Oxidoreductases; C503310:STEAP4 protein, human; C076529:TNFAIP3 protein, human; D000072598:Tumor Necrosis Factor alpha-Induced Protein 3