title: Amyloidosis: The Newer Discovered ALECT2 Associated with der7q add(7).
abstract: Amyloidosis is characterized by pathological deposition of abnormal protein aggregates in various tissues, AL protein being the commonest. ALECT 2 is the newest protein described, having a predisposition to affect the kidneys, sometimes the liver and rarely other organs. We present a case of renal amyloid ALECT 2 due to leucocyte cell derived chemotaxin 2, a novel amyloidogenic protein. The patient presented with mild proteinuria, scattered plasma cells on bone marrow examination and altered kappa/lambda ratio with associated cytogenetic abnormality of der7q add(7). It is essential to correctly type this protein and differentiate it from AL during diagnosis for appropriate and effective clinical management.
authors: Postgraduate Trainee, Department of Pathology, Apollo Gleneagles Hospital , Kolkata, West Bengal, India .
authors: Amrita
authors: A
authors: Chakrabarti
authors: Junior Consultant, Department of Clinical Hematology and Hemato-Oncology, Apollo Gleneagles Hospital , Kolkata, West Bengal, India .
authors: Priyanka
authors: P
authors: Samal
authors: Consultant, Department of Clinical Hematology and Bone Marrow Transplant, Advanced Medical Research Institute , Kolkata, West Bengal, India .
authors: Joydeep
authors: J
authors: Chakrabartty
keywords: AL Protein; Leucocyte derived chemotaxin 2; Renal amyloidosis; der7q add(7)