title: Selected metabolic aspects of elastin and collagen fiber proteolysis in diseases of the respiratory system - the significance of α1 antitrypsin deficiency.
abstract: The process of elastin and collagen fiber destruction was presented based on the example of the changes taking place in the course of chronic obstructive pulmonary disease and primary spontaneous pneumothorax. In 1963, when analyzing patients with α1 antitrypsin deficiency, Dr Laurell and Dr Eriksson hypothesized that elastolysis plays a role in the pathogenesis of emphysema, which marked the beginning of studies aimed at analyzing this process. The present work concerns new scientific reports regarding the hypothesis. The most important risk factors include protease-antiprotease imbalance and α1 antitrypsin protein deficiency.
authors: National Institute of Tuberculosis and Lung Diseases, Warsaw, Poland.
authors: Agata
authors: A
authors: Dżeljilji
authors: Department of Thoracic Surgery, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia in Katowice, Poland.
authors: Wojciech
authors: W
authors: Rokicki
authors: Center of Pulmonology and Thoracic Surgery, Bystra, Poland.
authors: Krzysztof
authors: K
authors: Karuś
keywords: protease-antiprotease imbalance; α1 antitrypsin