title: The utility of bone scintigraphy in the assessment of mandibular metabolism during long-term bisphosphonate administration.
abstract: The duration of antiresorptive therapy is an important risk factor for medication-related osteonecrosis of the jaw. We performed a pilot study using quantitative analysis by bone scintigraphy to test the hypothesis that mandibular metabolism is affected by long-term bisphosphonate (BP) therapy. Our primary objectives were to assess changes in bone metabolism of the mandible in response to long-term BP therapy and compare the bone metabolism changes of the mandible with other bone sites. We compared the metabolic difference at the site in the mandible unaffected by disease, the humerus and the femur between 14 osteoporosis patients who were being treated with BP (BP group) and 14 patients who were not being treated with BP (control group) using a quantitative analysis and bone scintigraphy. Study endpoints were the mean and maximum bone uptake values (BUVs) quantified using bone scintigraphy images of the mandible, humerus and femur. Quantified images of the site in the mandible unaffected by disease had significantly higher mean and maximum BUVs compared to the controls (mean, 0.74 vs. 0.49, p = 0.019; max., 1.29 vs. 0.85, p = 0.009, respectively). The mean and maximum BUV of femur ROIs in the BP group were significantly lower than those in control patients (mean BUV, 0.23 vs. 0.30, p = 0.039; max. BUV, 0.43 vs. 0.53, p = 0.024, respectively). This is the first report of mandible changes in response to long-term BP treatment, using bone scintigraphy. The results using bone scintigraphy demonstrated that the bone metabolism of the intact mandible is affected by a long-term administration of BP.
authors: Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, 761-0793, Kagawa, Japan. yumiko@med.kagawa-u.ac.jp.
authors: Yumiko
authors: http://orcid.org/0000-0002-9312-4349
authors: Y
authors: Ohbayashi
authors: Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, 761-0793, Kagawa, Japan.
authors: Fumi
authors: F
authors: Nakai
authors: Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, 761-0793, Kagawa, Japan.
authors: Akinori
authors: A
authors: Iwasaki
authors: Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, 761-0793, Kagawa, Japan.
authors: Takaaki
authors: T
authors: Ogawa
authors: Department of Radiology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, 761-0793, Kagawa, Japan.
authors: Yuka
authors: Y
authors: Yamamoto
authors: Department of Radiology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, 761-0793, Kagawa, Japan.
authors: Yoshihiro
authors: Y
authors: Nishiyama
authors: Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, 761-0793, Kagawa, Japan.
authors: Minoru
authors: M
authors: Miyake
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D059266:Bisphosphonate-Associated Osteonecrosis of the Jaw / Q000000981:diagnostic imaging*; D050071:Bone Density Conservation Agents / Q000008:administration & dosage* / Q000009:adverse effects; D016022:Case-Control Studies; D004164:Diphosphonates / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D005269:Femur / Q000000981:diagnostic imaging / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D006811:Humerus / Q000000981:diagnostic imaging / Q000187:drug effects / Q000378:metabolism; D008334:Mandible / Q000000981:diagnostic imaging* / Q000187:drug effects* / Q000378:metabolism*; D010024:Osteoporosis / Q000188:drug therapy; D011877:Radionuclide Imaging / Q000379:methods*; D019275:Radiopharmaceuticals; D013669:Technetium Tc 99m Medronate
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D019275:Radiopharmaceuticals; D013669:Technetium Tc 99m Medronate
keywords: Bisphosphonate; Bone scintigraphy; Metabolism; Osteonecrosis of the jaw