title: Anorexia Nervosa: Analysis of Trabecular Texture with CT.
abstract: Purpose To determine indexes of skeletal integrity by using computed tomographic (CT) trabecular texture analysis of the lumbar spine in patients with anorexia nervosa and normal-weight control subjects and to determine body composition predictors of trabecular texture. Materials and Methods This cross-sectional study was approved by the institutional review board and compliant with HIPAA. Written informed consent was obtained. The study included 30 women with anorexia nervosa (mean age ± standard deviation, 26 years ± 6) and 30 normal-weight age-matched women (control group). All participants underwent low-dose single-section quantitative CT of the L4 vertebral body with use of a calibration phantom. Trabecular texture analysis was performed by using software. Skewness (asymmetry of gray-level pixel distribution), kurtosis (pointiness of pixel distribution), entropy (inhomogeneity of pixel distribution), and mean value of positive pixels (MPP) were assessed. Bone mineral density and abdominal fat and paraspinal muscle areas were quantified with quantitative CT. Women with anorexia nervosa and normal-weight control subjects were compared by using the Student t test. Linear regression analyses were performed to determine associations between trabecular texture and body composition. Results Women with anorexia nervosa had higher skewness and kurtosis, lower MPP (P < .001), and a trend toward lower entropy (P = .07) compared with control subjects. Bone mineral density, abdominal fat area, and paraspinal muscle area were inversely associated with skewness and kurtosis and positively associated with MPP and entropy. Texture parameters, but not bone mineral density, were associated with lowest lifetime weight and duration of amenorrhea in anorexia nervosa. Conclusion Patients with anorexia nervosa had increased skewness and kurtosis and decreased entropy and MPP compared with normal-weight control subjects. These parameters were associated with lowest lifetime weight and duration of amenorrhea, but there were no such associations with bone mineral density. These findings suggest that trabecular texture analysis might contribute information about bone health in anorexia nervosa that is independent of that provided with bone mineral density.©RSNA, 2016.
authors: From the Department of Radiology (A.T., M.T., M.K.K., M.A.B.) and Neuroendocrine Unit (K.K.M., A.K.), Massachusetts General Hospital and Harvard Medical School, 55 Fruit St, Yawkey 6E, Boston, MA 02114.
authors: Azadeh
authors: A
authors: Tabari
authors: From the Department of Radiology (A.T., M.T., M.K.K., M.A.B.) and Neuroendocrine Unit (K.K.M., A.K.), Massachusetts General Hospital and Harvard Medical School, 55 Fruit St, Yawkey 6E, Boston, MA 02114.
authors: Martin
authors: M
authors: Torriani
authors: From the Department of Radiology (A.T., M.T., M.K.K., M.A.B.) and Neuroendocrine Unit (K.K.M., A.K.), Massachusetts General Hospital and Harvard Medical School, 55 Fruit St, Yawkey 6E, Boston, MA 02114.
authors: Karen K
authors: KK
authors: Miller
authors: From the Department of Radiology (A.T., M.T., M.K.K., M.A.B.) and Neuroendocrine Unit (K.K.M., A.K.), Massachusetts General Hospital and Harvard Medical School, 55 Fruit St, Yawkey 6E, Boston, MA 02114.
authors: Anne
authors: A
authors: Klibanski
authors: From the Department of Radiology (A.T., M.T., M.K.K., M.A.B.) and Neuroendocrine Unit (K.K.M., A.K.), Massachusetts General Hospital and Harvard Medical School, 55 Fruit St, Yawkey 6E, Boston, MA 02114.
authors: Mannudeep K
authors: MK
authors: Kalra
authors: From the Department of Radiology (A.T., M.T., M.K.K., M.A.B.) and Neuroendocrine Unit (K.K.M., A.K.), Massachusetts General Hospital and Harvard Medical School, 55 Fruit St, Yawkey 6E, Boston, MA 02114.
authors: Miriam A
authors: MA
authors: Bredella
mesh_terms: D000328:Adult; D000856:Anorexia Nervosa / Q000000981:diagnostic imaging / Q000503:physiopathology*; D000071556:Cancellous Bone / Q000000981:diagnostic imaging* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging / Q000503:physiopathology; D008875:Middle Aged; D011446:Prospective Studies; D014057:Tomography, X-Ray Computed / Q000379:methods*; D055815:Young Adult