title: Acid resistant zirconium phosphate for the long term application of68Ge/68Ga generator system.
abstract: The68Ge/68Ga generator system is an excellent source for producing ready-to-use Ga-68 in clinical Positron Emission Tomography (PET) applications. The column adsorbent is the key component for the68Ge/68Ga generator system. Therefore, several studies have been conducted to identify column materials with a stable and superior elution yield in an acidic eluent (0.1 N HCl solution). In this study, four different zirconium phosphates were synthesized with a particle size of 200-800nm, pore-size of 55∼190Å and surface area of 0.72-268m2g-1. Synthesized and studied amorphous zirconium phosphate (ZrP-1) exhibited excellent acid resistant properties for the 0.1 N HCl eluent and a large surface area of 268m2g-1. Amorphous ZrP-1 showed a good Ga-68 elution yield of 74% in 0.1 N HCl eluent accompanying extraordinary low breakthrough of Ge-68 (0.007%).
authors: Department of Advanced Materials Chemistry, College of Science and Technology, Dongguk University-Gyeongju, Gyeongbuk 780-714, Republic of Korea; Radiation Instrumentation Research Division, Korea Atomic Energy Research Institute, Jeongeup 580-185, Republic of Korea.
authors: Jun Young
authors: JY
authors: Lee
authors: Radiation Instrumentation Research Division, Korea Atomic Energy Research Institute, Jeongeup 580-185, Republic of Korea.
authors: Chirag K
authors: CK
authors: Vyas
authors: Radiation Instrumentation Research Division, Korea Atomic Energy Research Institute, Jeongeup 580-185, Republic of Korea.
authors: Bo-Ram
authors: BR
authors: Kim
authors: Radiation Instrumentation Research Division, Korea Atomic Energy Research Institute, Jeongeup 580-185, Republic of Korea.
authors: Hee Jung
authors: HJ
authors: Kim
authors: Radiation Instrumentation Research Division, Korea Atomic Energy Research Institute, Jeongeup 580-185, Republic of Korea.
authors: Min Goo
authors: MG
authors: Hur
authors: Radiation Instrumentation Research Division, Korea Atomic Energy Research Institute, Jeongeup 580-185, Republic of Korea.
authors: Seung Dae
authors: SD
authors: Yang
authors: Radiation Instrumentation Research Division, Korea Atomic Energy Research Institute, Jeongeup 580-185, Republic of Korea. Electronic address: parkjh@kaeri.re.kr.
authors: Jeong Hoon
authors: JH
authors: Park
authors: Department of Advanced Materials Chemistry, College of Science and Technology, Dongguk University-Gyeongju, Gyeongbuk 780-714, Republic of Korea. Electronic address: swkim@dongguk.ac.kr.
authors: Sang Wook
authors: SW
authors: Kim
keywords: (68)Ge/(68)Ga; Acid-resistance; Adsorbent; Radioisotope generator; Zirconium phosphate