title: Association of Lumbar Spondylolisthesis With Low Back Pain and Symptomatic Lumbar Spinal Stenosis in a Population-based Cohort: The Wakayama Spine Study.
abstract: METHODS
  Cross-sectional study.
  
  
  OBJECTIVE
  To determine the association between lumbar spondylolisthesis and low back pain and symptomatic lumbar spinal stenosis (LSS) in a population-based cohort.
  
  
  BACKGROUND
  The basic epidemiology of lumbar spondylolisthesis is not well known. There is little information regarding the association between lumbar spondylolisthesis and clinical symptoms such as low back pain and LSS symptoms.
  
  
  METHODS
  This cross-sectional study included data from 938 participants (308 males, 630 females; mean age, 67.3 years; range, 40-93 years). Lumbar spondylolisthesis was defined as a slip of ≥5%. Diagnostic criteria for symptomatic LSS required the presence of both leg symptoms and radiographic LSS findings on magnetic resonance imaging. The prevalence of low back pain and symptomatic LSS was compared between those with or without spondylolisthesis. Furthermore, we determined the association between the amount of slippage and presence of symptomatic LSS.
  
  
  RESULTS
  The prevalence of spondylolisthesis at any level was 15.8% in the total sample, 13.0% in males, and 17.1% in females; the prevalence was not significantly different between males and females (P = 0.09). In both, males and females, symptomatic LSS was related to spondylolisthesis [odds ratio (OR): 2.07; 95% CI: 1.20-3.44]; however, no such association was found for spondylolisthesis and presence of low back pain. The amount of slippage was not related to the presence of symptomatic LSS (P = 0.93).
  
  
  CONCLUSIONS
  This population-based cohort study revealed that lumbar spondylolisthesis had a closer association with leg symptoms than with low back pain. There was a significant difference in the presence of symptomatic LSS between participants with and without spondylolisthesis. However, the amount of slippage was not related to the presence of symptomatic LSS.
  
  
  METHODS
  3.
authors: Wakayama Medical University, Wakayama, Japan.
authors: Yuyu
authors: Y
authors: Ishimoto
authors: Department of Joint Disease Research, 22nd Century Medical and Research Center, University of Tokyo, Tokyo, Japan.
authors: Noriko
authors: N
authors: Yoshimura
authors: Department of Clinical Motor System Medicine, 22nd Century Medical and Research Center, University of Tokyo, Tokyo, Japan.
authors: Shigeyuki
authors: S
authors: Muraki
authors: Wakayama Medical University, Wakayama, Japan.
authors: Hiroshi
authors: H
authors: Yamada
authors: Wakayama Medical University, Wakayama, Japan.
authors: Keiji
authors: K
authors: Nagata
authors: Wakayama Medical University, Wakayama, Japan.
authors: Hiroshi
authors: H
authors: Hashizume
authors: Wakayama Medical University, Wakayama, Japan.
authors: Noboru
authors: N
authors: Takiguchi
authors: Wakayama Medical University, Wakayama, Japan.
authors: Akihito
authors: A
authors: Minamide
authors: Department of Medical Research and Management for Musculoskeletal Pain, 22nd Century Medical and Research Center, University of Tokyo, Tokyo, Japan.
authors: Hiroyuki
authors: H
authors: Oka
authors: Department of Orthopedic Surgery, Sensory and Motor System Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
authors: Sakae
authors: S
authors: Tanaka
authors: JCHO Tokyo Shinjuku Medical Center, Tokyo, Japan.
authors: Hiroshi
authors: H
authors: Kawaguchi
authors: National Rehabilitation Center for Persons with Disabilities, Saitama, Japan.
authors: Kozo
authors: K
authors: Nakamura
authors: National Rehabilitation Center for Persons with Disabilities, Saitama, Japan.
authors: Toru
authors: T
authors: Akune
authors: Wakayama Medical University, Wakayama, Japan.
authors: Munehito
authors: M
authors: Yoshida
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015897:Comorbidity; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D017116:Low Back Pain / Q000000981:diagnostic imaging / Q000453:epidemiology*; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D013130:Spinal Stenosis / Q000000981:diagnostic imaging / Q000453:epidemiology*; D013168:Spondylolisthesis / Q000000981:diagnostic imaging / Q000453:epidemiology*