title: Structural and Thermal Behavior of Meglumine-Based Supra-Amphiphiles in Bulk and Assembled in Water.
abstract: Supra-amphiphiles are a new class of building blocks that are fabricated by means of noncovalent forces. In this work, we studied the formation of supra-amphiphiles by combining hydrophilic meglumine (MEG) with hydrophobic maleated castor oils (MACO). Spectroscopic analysis demonstrated that ionic interactions are the main driving force in the fabrication of these materials. Subsequently, supra-amphiphile/water systems were examined for their structure and water behavior by polarized optical microscopy (POM), small-angle X-ray scattering (SAXS), and differential scanning calorimetry (DSC). Micellar and lamellar liquid crystalline phases were observed. Finally, we observed that the supra-amphiphiles produced using an excess of MEG retain a large amount of water. As bound water plays an important role in biointerfacial interactions, we anticipate that these materials will display a pronounced potential for biomedical applications.
authors: School of Pharmaceutical Sciences, São Paulo State University , Rodovia Araraquara-Jau Km 1, Araraquara, SP 14801-902, Brazil.|Chemistry Institute, São Paulo State University , R. Prof. Francisco Degni, s/n, Araraquara, SP 14800-060, Brazil.
authors: Leonardo M B
authors: LM
authors: Ferreira
authors: Chemistry Institute, São Paulo State University , R. Prof. Francisco Degni, s/n, Araraquara, SP 14800-060, Brazil.
authors: Suzy S S
authors: SS
authors: Kurokawa
authors: School of Pharmaceutical Sciences, São Paulo State University , Rodovia Araraquara-Jau Km 1, Araraquara, SP 14801-902, Brazil.
authors: Jovan D
authors: JD
authors: Alonso
authors: Chemistry Institute, São Paulo State University , R. Prof. Francisco Degni, s/n, Araraquara, SP 14800-060, Brazil.
authors: Douglas Lopes
authors: DL
authors: Cassimiro
authors: Chemistry Institute, São Paulo State University , R. Prof. Francisco Degni, s/n, Araraquara, SP 14800-060, Brazil.
authors: Ana Luiza Ribeiro de
authors: AL
authors: Souza
authors: Chemistry Institute, São Paulo State University , R. Prof. Francisco Degni, s/n, Araraquara, SP 14800-060, Brazil.
authors: Mariana
authors: M
authors: Fonseca
authors: Department of Chemistry, Federal University of Sergipe, UFS , Vereador Olimpio Grande Avenue, Itabaiana, SE 49500-000, Brazil.
authors: Victor Hugo V
authors: VH
authors: Sarmento
authors: Department of Chemistry and Environmental Sciences, IBILCE, São Paulo State University , R. Cristóvão Colombo, 2265, São José do Rio Preto, SP 15054-000, Brazil.
authors: Luis Octávio
authors: LO
authors: Regasini
authors: Chemistry Institute, São Paulo State University , R. Prof. Francisco Degni, s/n, Araraquara, SP 14800-060, Brazil.
authors: Clóvis Augusto
authors: CA
authors: Ribeiro