title: Serological Responses to Filarial Antigens in Malian Children Attending Elementary Schools.
abstract: Dried blood spots (DBS) were collected from 805 children attending 42 elementary schools in the regions of Mopti, Sikasso, Koulikoro, and the regional capital of Bamako in Mali as part of an evaluation of a school health intervention. Eluted immunoglobulin (Ig) G from the DBS was assessed by a multiplex bead assay (MBA) for two filariasis antigens, Wuchereria bancrofti, Wb123, and Brugia malayi, Bm14, to determine the effectiveness of mass drug administration (MDA) programs to eliminate lymphatic filariasis (LF). The prevalence of positive IgG responses in the children to each antigen was less than 1%, indicating effectiveness of the MDA against LF. The MBA is an excellent serological platform that provides cost-effective opportunities to evaluate public health activities beyond the survey targets.
authors: Division of Foodborne, Waterborne, and Environmental Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia. dmm3@cdc.gov.
authors: Delynn M
authors: DM
authors: Moss
authors: Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, Georgia.
authors: Anna N
authors: AN
authors: Chard
authors: Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, Georgia.
authors: Victoria
authors: V
authors: Trinies
authors: Faculty of Medicine and Odontostomatology, Malaria Research and Training Center, University of Sciences, Techniques and Technologies of Bamako (USTTB), Bamako, Mali.
authors: Seydou
authors: S
authors: Doumbia
authors: Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, Georgia.
authors: Matthew C
authors: MC
authors: Freeman
authors: Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, Georgia.
authors: Patrick J
authors: PJ
authors: Lammie
mesh_terms: D000293:Adolescent; D000818:Animals; D000909:Antibodies, Helminth / Q000097:blood; D000947:Antigens, Helminth / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D008302:Mali / Q000453:epidemiology; D012574:Schools; D016036:Seroepidemiologic Studies; D012698:Serologic Tests / Q000379:methods*; D014958:Wuchereria bancrofti; D055815:Young Adult
chemical_list: D000909:Antibodies, Helminth; D000947:Antigens, Helminth; D007074:Immunoglobulin G