title: Hydrolytic conversion of amorphous calcium phosphate into apatite accompanied by sustained calcium and orthophosphate ions release.
abstract: The aim of this study is to investigate the calcium and orthophosphate ions release during the transformation of amorphous calcium phosphate (ACP) to hydroxyapatite (HA) in aqueous solution. The ACP is prepared by a wet chemical method and further immersed in the distilled water for various time points till 14d. The release of calcium and orthophosphate ions is measured with calcium and phosphate colorimetric assay kits, respectively. The transition of ACP towards HA is detected by x-ray diffraction (XRD), transmission electron microscopy (TEM), and fourier transform infrared spectroscopy (FTIR). The results indicate that the morphological conversion of ACP to HA occurs within the first 9h, whereas the calcium and orthophosphate ions releases last for over 7d. Such sustained calcium and orthophosphate ions release is very useful for ACP as a candidate material for hard tissue regeneration.
authors: Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China; BUAA Research Institute, Guangzhou 510530, China; Research Institute of Beihang University in Shenzhen, Shenzhen 518057, China. Electronic address: nxf@buaa.edu.cn.
authors: Xufeng
authors: X
authors: Niu
authors: Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China.
authors: Siqian
authors: S
authors: Chen
authors: Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China.
authors: Feng
authors: F
authors: Tian
authors: Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China.
authors: Lizhen
authors: L
authors: Wang
authors: State Key Laboratory of New Ceramic and Fine Processing, Tsinghua University, Beijing 100084, China.
authors: Qingling
authors: Q
authors: Feng
authors: Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China. Electronic address: yubofan@buaa.edu.cn.
authors: Yubo
authors: Y
authors: Fan
mesh_terms: D001031:Apatites / Q000737:chemistry*; D002118:Calcium / Q000737:chemistry*; D002130:Calcium Phosphates / Q000737:chemistry*; D003460:Crystallization; D017886:Durapatite / Q000737:chemistry; D006868:Hydrolysis; D007477:Ions; D007700:Kinetics; D010710:Phosphates / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction
chemical_list: D001031:Apatites; D002130:Calcium Phosphates; D007477:Ions; D010710:Phosphates; C519480:amorphous calcium phosphate; D017886:Durapatite; D002118:Calcium
keywords: Amorphous calcium phosphate; Dental material; Hydroxyapatite; Ion release