title: Neurobehaviour at term-equivalent age and neurodevelopmental outcomes at 2 years in infants born moderate-to-late preterm.
abstract: OBJECTIVE
  To examine the association between newborn neurobehavioural assessments and neurodevelopmental outcomes at 2 years in infants born moderate-to-late preterm (MLPT).
  
  
  METHODS
  Two-hundred and one infants born MLPT (born 32-36+6wks' gestation) were assessed with the Hammersmith Neonatal Neurological Examination (HNNE) and NICU Network Neurobehavioral Scale (NNNS), with suboptimal performance defined as scores lower than the 10th centile. Development was assessed at 2 years corrected age with the Bayley Scales of Infant and Toddler Development 3rd Edition, with delay defined as scores less than 1 standard deviation (SD) below the mean. The relationships between neurobehaviour at term and Bayley-III cognitive, language, and motor scales at 2 years were examined using linear regression.
  
  
  RESULTS
  Increased odds for cognitive delay were associated with suboptimal HNNE total scores (odds ratio [OR] 2.66; 95% confidence interval [CI] 1.14-6.23, p=0.020) and suboptimal NNNS excitability (OR 3.01; 95% CI 1.33-6.82, p=0.008) and lethargy (OR 4.05; 95% CI 1.75-9.31, p=0.001) scores. Suboptimal lethargy scores on the NNNS were associated with increased odds of language (OR 5.64; 95% CI 1.33-23.85, p=0.019) and motor delay (OR: 6.86; 95% CI 1.64-28.71, p=0.08).
  
  
  CONCLUSIONS
  Suboptimal performance on specific aspects of newborn neurobehavioural assessments is associated with neurodevelopmental delay at 2 years in children born MLPT.
authors: Department of Physiotherapy, University of Melbourne, Melbourne, Vic, Australia.|Murdoch Childrens Research Institute, Melbourne, Vic, Australia.|Newborn Research, Royal Women's Hospital, Melbourne, Vic, Australia.
authors: Alicia J
authors: AJ
authors: Spittle
authors: Murdoch Childrens Research Institute, Melbourne, Vic, Australia.|Newborn Research, Royal Women's Hospital, Melbourne, Vic, Australia.|Paediatric Infant Perinatal Emergency Retrieval (PIPER), The Royal Children's Hospital, Melbourne, Vic, Australia.
authors: Jennifer M
authors: JM
authors: Walsh
authors: Murdoch Childrens Research Institute, Melbourne, Vic, Australia.
authors: Cody
authors: C
authors: Potter
authors: Murdoch Childrens Research Institute, Melbourne, Vic, Australia.|Newborn Research, Royal Women's Hospital, Melbourne, Vic, Australia.
authors: Emma
authors: E
authors: Mcinnes
authors: Murdoch Childrens Research Institute, Melbourne, Vic, Australia.|Newborn Research, Royal Women's Hospital, Melbourne, Vic, Australia.|Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, Vic, Australia.
authors: Joy E
authors: JE
authors: Olsen
authors: Murdoch Childrens Research Institute, Melbourne, Vic, Australia.|Department of Paediatrics, University of Melbourne, Melbourne, Vic, Australia.
authors: Katherine J
authors: KJ
authors: Lee
authors: Murdoch Childrens Research Institute, Melbourne, Vic, Australia.|Department of Paediatrics, University of Melbourne, Melbourne, Vic, Australia.
authors: Peter J
authors: PJ
authors: Anderson
authors: Murdoch Childrens Research Institute, Melbourne, Vic, Australia.|Newborn Research, Royal Women's Hospital, Melbourne, Vic, Australia.|Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, Vic, Australia.|Department of Paediatrics, University of Melbourne, Melbourne, Vic, Australia.
authors: Lex W
authors: LW
authors: Doyle
authors: Murdoch Childrens Research Institute, Melbourne, Vic, Australia.|Newborn Research, Royal Women's Hospital, Melbourne, Vic, Australia.|Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, Vic, Australia.
authors: Jeanie L Y
authors: JL
authors: Cheong
mesh_terms: D002657:Child Development; D002675:Child, Preschool; D003072:Cognition Disorders / Q000209:etiology; D002658:Developmental Disabilities / Q000175:diagnosis / Q000503:physiopathology*; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009460:Neurologic Examination; D009483:Neuropsychological Tests; D017063:Outcome Assessment, Health Care; D047928:Premature Birth / Q000175:diagnosis / Q000503:physiopathology*; D012189:Retrospective Studies