title: Inverted Micelle-in-Micelle Configuration in Cationic/Carbohydrate Surfactant Mixtures.
abstract: Nuclear magnetic resonance is applied to investigate the relative positions and interactions between cationic and non-ionic carbohydrate-based surfactants in mixed micelles with D2O as the solvent. This is accomplished by using relaxation measurements [spin-lattice (T1) and spin-spin (T2) analysis] and nuclear Overhauser effect spectroscopy (NOESY). This study focuses on the interactions of n-octyl β-d-glucopyranoside (C8G1) and β-d-xylopyranoside (C8X1) with the cationic surfactant hexadecyltrimethylammonium bromide (C16TAB). Whereas the interactions between carbohydrate and cationic surfactants are thermodynamically favorable, the NOESY results suggest that both of the sugar head groups are located preferentially at the interior core of the mixed micelles, so that they are not directly exposed to the bulk solution. The more hydrophilic sugar headgroups of C8G1 have more mobility than sugar heads of C8X1 owing to increased hydration. Herein, an inverted carbohydrate configuration in mixed micelles is proposed for the first time and supported by fluorescence spectroscopy experiments. This inverted carbohydrate headgroup configuration would limit the use of these mixed surfactants when access to the carbohydrate headgroup is important, but may present new opportunities where the carbohydrate-rich core of the micelles can be exploited.
authors: Chemical and Materials Engineering Department, University of Kentucky, Lexington, KY, 40506-0046, USA.
authors: Saikat
authors: S
authors: Das
authors: Department of Environmental and Occupational Health, University of Iowa, Iowa City, IA, 52242, USA.
authors: Wenjin
authors: W
authors: Xu
authors: Department of Environmental and Occupational Health, University of Iowa, Iowa City, IA, 52242, USA.
authors: Hans-Joachim
authors: http://orcid.org/0000-0001-9163-927X
authors: HJ
authors: Lehmler
authors: Department of Chemistry, University of Kentucky, Lexington, KY, 40506-0055, USA.
authors: Anne-Frances
authors: AF
authors: Miller
authors: Chemical and Materials Engineering Department, University of Kentucky, Lexington, KY, 40506-0046, USA.
authors: Barbara L
authors: BL
authors: Knutson
authors: Chemical and Materials Engineering Department, University of Kentucky, Lexington, KY, 40506-0046, USA.
authors: Stephen E
authors: http://orcid.org/0000-0002-8615-7564
authors: SE
authors: Rankin
mesh_terms: D002412:Cations / Q000737:chemistry; D000077286:Cetrimonium; D002593:Cetrimonium Compounds / Q000737:chemistry*; D006027:Glycosides / Q000737:chemistry*; D008823:Micelles; D013050:Spectrometry, Fluorescence; D013501:Surface-Active Agents / Q000737:chemistry*; D013816:Thermodynamics
chemical_list: D002412:Cations; D002593:Cetrimonium Compounds; D006027:Glycosides; D008823:Micelles; D013501:Surface-Active Agents; D000077286:Cetrimonium
keywords: asymmetric vesicles; micelle structure; mixed surfactants; nuclear magnetic resonance spectroscopy; self-assembly