title: Two-Component Assembly of Thiochroman-4-ones and Tetrahydrothiopyran-4-ones Using a Rhodium-Catalyzed Alkyne Hydroacylation/Thio-Conjugate-Addition Sequence.
abstract: β'-Thio-substituted-enones, assembled from the combination of β-tert-butylthio-substituted aldehydes and alkynes, using rhodium catalysis, are shown to smoothly undergo in situ intramolecular S-conjugate addition to deliver a range of S-heterocycles in a one-pot process. Aryl, alkenyl, and alkyl aldehydes can all be employed, to provide thiochroman-4-ones, hexahydro-4H-thiochromen-4-ones, and tetrahydrothiopyran-4-ones, respectively. A variety of in situ oxidations are also performed, allowing access to S,S-dioxide derivatives, as well as unsaturated variants.
authors: Department of Chemistry, University of Oxford, Chemistry Research Laboratory , Mansfield Road, Oxford, OX1 3TA, U.K.
authors: Anaïs
authors: A
authors: Bouisseau
authors: Department of Chemistry, University of Oxford, Chemistry Research Laboratory , Mansfield Road, Oxford, OX1 3TA, U.K.
authors: John
authors: J
authors: Glancy
authors: Department of Chemistry, University of Oxford, Chemistry Research Laboratory , Mansfield Road, Oxford, OX1 3TA, U.K.
authors: Michael C
authors: MC
authors: Willis