title: [Immune Tolerance Mediated by TIM-3,LAG-3 and BTLA and Their Reversion in Hematological Malignancies-Review].
abstract: The main mechanism of tumor immune suppression is due to the T cell exhaustion which is mediated by abnormal expression of T-cell immunosuppressive receptors in immune cells. Blocking these molecules may restore partial or all functions of T cells. This article reviews the advance on the role of the newly discovered T cell immuno-suppressive receptors such as TIM-3, LAG-3 and BTLA, including their mediated T cell-immune tolerance and the study of targeted immunotherapy in hematological malignancies, so as to provide the new strategy for immune-targeted therapy for hematological malignancies.
authors: Institute of Hematology, Medical College, Jinan University, Guangzhou 510632,Guangdong Province, China.
authors: Shao-Hua
authors: SH
authors: Chen
authors: Department of Clinical Laboratorial Examination, The First Affiliated Hospital, Jinan University, Guangzhou 510632,Guangdong Province, China.
authors: Xiang-Feng
authors: XF
authors: Zha
authors: Institute of Hematology, Medical College, Key Laboratory for Regenerative Medicine of Ministry of Education; Jinan University, Guangzhou 510632,Guangdong Province, China. E-mail: jnyangqiuli@163.com.
authors: Yang-Qiu
authors: YQ
authors: Li
mesh_terms: D015703:Antigens, CD; D019337:Hematologic Neoplasms; D000072597:Hepatitis A Virus Cellular Receptor 2; D006801:Humans; D007108:Immune Tolerance; D007167:Immunotherapy; D011971:Receptors, Immunologic; D013601:T-Lymphocytes; D000093322:Lymphocyte Activation Gene 3 Protein
chemical_list: D015703:Antigens, CD; C482586:BTLA protein, human; D000072597:Hepatitis A Virus Cellular Receptor 2; D011971:Receptors, Immunologic; D000093322:Lymphocyte Activation Gene 3 Protein; C000720326:Lag3 protein, human