title: Antigen Presentation to B Cells.
abstract: Unlike T cells that recognize digested peptides, B cells recognize their cognate antigen in its native form. The B cell receptor used in recognition can also be secreted to bind to antigens and initiate multiple effector functions such as phagocytosis, complement activation, or neutralization of receptors. While B cells can interact with soluble antigens, it is now clear that the presentation of membrane-bound antigen plays a crucial role in B cell activation, and in particular during affinity-maturation, the process during which high-affinity B cells are selected. In this review we discuss how native antigen is presented to B cells and its impact at several stages of B cell responses.
authors: Program in Cellular and Molecular Medicine, Boston Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA; Current address: Department of Cell Biology and Histology, Academic Medical Center, Amsterdam, 1105 AZ, The Netherlands.
authors: Balthasar A
authors: BA
authors: Heesters
authors: Program in Cellular and Molecular Medicine, Boston Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.
authors: Cees E
authors: CE
authors: van der Poel
authors: Program in Cellular and Molecular Medicine, Boston Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.
authors: Abhishek
authors: A
authors: Das
authors: Program in Cellular and Molecular Medicine, Boston Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA. Electronic address: michael.carroll@childrens.harvard.edu.
authors: Michael C
authors: MC
authors: Carroll
mesh_terms: D000818:Animals; D000915:Antibody Affinity; D017951:Antigen Presentation; D000938:Antigen-Presenting Cells / Q000276:immunology*; D000941:Antigens / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology*; D060966:Clonal Selection, Antigen-Mediated; D003167:Complement Activation; D006801:Humans; D008213:Lymphocyte Activation; D010587:Phagocytosis; D011947:Receptors, Antigen, B-Cell / Q000378:metabolism*
chemical_list: D000941:Antigens; D011947:Receptors, Antigen, B-Cell