title: Bilateral pelvic lymph node dissection for Chinese patients with penile cancer: a multicenter collaboration study.
abstract: BACKGROUND
  Current guidelines recommend pelvic lymphadenectomy (PLND) for patients with pelvic lymph node metastasis and special state. However, these data and recommendations do not distinguish the role of PLND in different patient groups and confirm the final benefits. The aim of this study was to confirm the efficacy of pelvic lymphadenectomy (PLND) for the different groups of patients.
  
  
  METHODS
  Data obtained from 7 centers were retrospectively analyzed. Of the patients, 190 pN2-3 penile carcinoma patients confirmed by bilateral inguinal lymph node excision were included in this study. Sixty-nine and 121 of these patients did and did not undergo bilateral PLND, respectively. The baseline differences from the patients were matched by propensity score analysis.
  
  
  RESULTS
  In this study, the Kaplan-Meier estimated disease-specific survival (DSS) was not significantly different between the PLND and no-PLND groups (P = 0.796). According to the propensity score matching for T stage, N stage, grade, adjuvant therapies, and lymph node stage (number of inguinal lymph node metastasis and extranodal extension), 48 patients were selected for each group. Among the pN2 patients, the PLND group showed higher DSS rates than the no-surgery group (P = 0.030). However, even after matching, survival did not differ between the PLND and no-PLND patients among all patients (P = 0.609) and pN3 patients (P = 0.417) with comparable DSS.
  
  
  CONCLUSIONS
  Bilateral PLND may improve survival in pN2 patients. Men with pN3 may not benefit from bilateral PLND.
authors: Department of Urology, Sun Yat-Sen University Cancer Center, Guangzhou, People's Republic of China.|State Key Laboratory of Oncology in Southern China, Guangzhou, People's Republic of China.|Collaborative Innovation Center of Cancer Medicine, Guangzhou, People's Republic of China.
authors: Zai-Shang
authors: ZS
authors: Li
authors: Department of Urology, Sun Yat-Sen University Cancer Center, Guangzhou, People's Republic of China.|State Key Laboratory of Oncology in Southern China, Guangzhou, People's Republic of China.|Collaborative Innovation Center of Cancer Medicine, Guangzhou, People's Republic of China.
authors: Chuang-Zhong
authors: CZ
authors: Deng
authors: Department of Urology, Sun Yat-Sen University Cancer Center, Guangzhou, People's Republic of China.|State Key Laboratory of Oncology in Southern China, Guangzhou, People's Republic of China.|Collaborative Innovation Center of Cancer Medicine, Guangzhou, People's Republic of China.
authors: Kai
authors: K
authors: Yao
authors: Department of Urology, Affiliated Cancer Hospital of Guangxi Medical University, Nanning, People's Republic of China.
authors: Yong
authors: Y
authors: Tang
authors: Department of Urology Oncological Surgery, Chongqing Cancer Hospital and Institute and Cancer Center, Chongqing, China.
authors: Nan
authors: N
authors: Liu
authors: Department of Urology, Affiliated Tumor Hospital of Xinjiang Medical University, Ürümchi, People's Republic of China.
authors: Peng
authors: P
authors: Chen
authors: Department of Urology, Cancer Center of Guangzhou Medical University, Guangzhou, People's Republic of China.
authors: Bin
authors: B
authors: Wang
authors: Department of Urology, West China Hospital of Sichuan University, Chengdu, People's Republic of China.
authors: Xiang
authors: X
authors: Li
authors: Department of Urology, The First People's Hospital of Chenzhou, Chenzhou, People's Republic of China.
authors: Xiao-Feng
authors: XF
authors: Chen
authors: Department of Urology, Sichuan Cancer Hospital, Chengdu, People's Republic of China.
authors: Hong
authors: H
authors: Liao
authors: Department of Urology, Dong Guan People's Hospital, Dongguan, People's Republic of China.
authors: Qi-Wu
authors: QW
authors: Mi
authors: Department of Urology, Yunnan Provincial Tumor Hospital, The Third Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, People's Republic of China.
authors: Yong-Hong
authors: YH
authors: Lei
authors: State Key Laboratory of Oncology in Southern China, Guangzhou, People's Republic of China.|Collaborative Innovation Center of Cancer Medicine, Guangzhou, People's Republic of China.|School of Life Science, Sun Yat-Sen UniversitySchool of Life Science, Guangzhou, People's Republic of China.
authors: Qi
authors: Q
authors: Zhao
authors: Guangdong Provincial Center for Skin Disease and STI Control, Guangzhou, People's Republic of China.
authors: Pei-Zhen
authors: PZ
authors: Zhao
authors: State Key Laboratory of Oncology in Southern China, Guangzhou, People's Republic of China.|Collaborative Innovation Center of Cancer Medicine, Guangzhou, People's Republic of China.|Department of Medical Oncology, Cancer Center of Sun Yat-Sen University, Guangzhou, People's Republic of China.
authors: Xue-Ying
authors: XY
authors: Li
authors: Department of Urology, Sun Yat-Sen University Cancer Center, Guangzhou, People's Republic of China.|State Key Laboratory of Oncology in Southern China, Guangzhou, People's Republic of China.|Collaborative Innovation Center of Cancer Medicine, Guangzhou, People's Republic of China.
authors: Jie-Ping
authors: JP
authors: Chen
authors: Department of Urology, Sun Yat-Sen University Cancer Center, Guangzhou, People's Republic of China.|State Key Laboratory of Oncology in Southern China, Guangzhou, People's Republic of China.|Collaborative Innovation Center of Cancer Medicine, Guangzhou, People's Republic of China.
authors: Qiang-Hua
authors: QH
authors: Zhou
authors: Department of Urology, Sun Yat-Sen University Cancer Center, Guangzhou, People's Republic of China.|State Key Laboratory of Oncology in Southern China, Guangzhou, People's Republic of China.|Collaborative Innovation Center of Cancer Medicine, Guangzhou, People's Republic of China.
authors: Zi-Ke
authors: ZK
authors: Qin
authors: Department of Urology, Sun Yat-Sen University Cancer Center, Guangzhou, People's Republic of China.|State Key Laboratory of Oncology in Southern China, Guangzhou, People's Republic of China.|Collaborative Innovation Center of Cancer Medicine, Guangzhou, People's Republic of China.
authors: Zhuo-Wei
authors: ZW
authors: Liu
authors: Department of Urology, Sun Yat-Sen University Cancer Center, Guangzhou, People's Republic of China.|State Key Laboratory of Oncology in Southern China, Guangzhou, People's Republic of China.|Collaborative Innovation Center of Cancer Medicine, Guangzhou, People's Republic of China.
authors: Yong-Hong
authors: YH
authors: Li
authors: Department of Urology, Sun Yat-Sen University Cancer Center, Guangzhou, People's Republic of China.|State Key Laboratory of Oncology in Southern China, Guangzhou, People's Republic of China.|Collaborative Innovation Center of Cancer Medicine, Guangzhou, People's Republic of China.
authors: Yun-Lin
authors: YL
authors: Ye
authors: Department of Urology, Sun Yat-Sen University Cancer Center, Guangzhou, People's Republic of China.|State Key Laboratory of Oncology in Southern China, Guangzhou, People's Republic of China.|Collaborative Innovation Center of Cancer Medicine, Guangzhou, People's Republic of China.
authors: Hua
authors: H
authors: Tu
authors: Department of Urology, Cancer Center of Guangzhou Medical University, Guangzhou, People's Republic of China.
authors: Zi-Jun
authors: ZJ
authors: Zou
authors: Department of Urology, Affiliated Tumor Hospital of Xinjiang Medical University, Ürümchi, People's Republic of China.
authors: Xing
authors: X
authors: Bi
authors: Department of Urology, Affiliated Tumor Hospital of Xinjiang Medical University, Ürümchi, People's Republic of China.
authors: Feng
authors: F
authors: Yang
authors: Department of Urology, Sichuan Cancer Hospital, Chengdu, People's Republic of China.
authors: Ying-Ming
authors: YM
authors: Xiao
authors: Department of Urology, Cancer Center of Guangzhou Medical University, Guangzhou, People's Republic of China.
authors: Jing
authors: J
authors: Li
authors: Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, People's Republic of China.
authors: Xiang-Tian
authors: XT
authors: Lin
authors: Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, People's Republic of China.
authors: Wei-Cong
authors: WC
authors: Liang
authors: Department of Urology, Sun Yat-Sen University Cancer Center, Guangzhou, People's Republic of China. hanhui@sycucc.org.cn.|State Key Laboratory of Oncology in Southern China, Guangzhou, People's Republic of China. hanhui@sycucc.org.cn.|Collaborative Innovation Center of Cancer Medicine, Guangzhou, People's Republic of China. hanhui@sycucc.org.cn.
authors: Hui
authors: H
authors: Han
authors: Department of Urology, Sun Yat-Sen University Cancer Center, Guangzhou, People's Republic of China. Zhoufj@sycucc.org.cn.|State Key Laboratory of Oncology in Southern China, Guangzhou, People's Republic of China. Zhoufj@sycucc.org.cn.|Collaborative Innovation Center of Cancer Medicine, Guangzhou, People's Republic of China. Zhoufj@sycucc.org.cn.
authors: Fang-Jian
authors: FJ
authors: Zhou
mesh_terms: D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000556:secondary / Q000601:surgery*; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D006801:Humans; D053208:Kaplan-Meier Estimate; D008197:Lymph Node Excision; D008198:Lymph Nodes / Q000473:pathology / Q000601:surgery*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D010388:Pelvis; D010412:Penile Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D012189:Retrospective Studies; D016896:Treatment Outcome
keywords: Lymph node excision; Mortality; Neoplasm metastasis; Penile neoplasms