title: Regulatory mechanisms of microRNAs in lung cancer stem cells.
abstract: Increasing evidence suggests that cancer stem cells (CSCs) are a key occurrence in the process of many human cancers. Lung cancer is the most common aggressive malignancy and cause of cancer death worldwide. The research on lung cancer stem cells has been highlighted for many years. Lung CSCs seem to play a major role in lung cancer metastasis, drug resistance and tumour-self-renewal. MicroRNAs (miRNAs), a class of newly emerging small noncoding RNAs that act as post-transcriptional regulators of gene expression, have been demonstrated to serve as a vital player in fine-tuning a number of biological activities ranging from embryogenesis to programmed cell death as well as tumourigenesis. In recent years, several miRNAs have been highlighted to be specifically expressed in CSCs. The miRNA profile of CSCs is remarkably different from non-stem cancer cells. As such, many miRNAs have been shown to regulate self-renewal and differentiation properties of CSCs. In this review, we present the latest findings on miRNAs that regulate the tumour microenvironment of lung CSCs with the goal to prompt the development of novel therapeutic strategies for patients with lung cancer.
authors: Department of Thoracic Surgery, Renmin Hospital of Wuhan University, Wuhan, 430060 China.
authors: Tao
authors: T
authors: Fan
authors: Department of Thoracic Surgery, Renmin Hospital of Wuhan University, Wuhan, 430060 China.
authors: Wei
authors: W
authors: Wang
authors: Department of Thoracic Surgery, Renmin Hospital of Wuhan University, Wuhan, 430060 China.
authors: Boyou
authors: B
authors: Zhang
authors: Department of Thoracic Surgery, Renmin Hospital of Wuhan University, Wuhan, 430060 China.
authors: Yao
authors: Y
authors: Xu
authors: Department of Thoracic Surgery, Renmin Hospital of Wuhan University, Wuhan, 430060 China.
authors: Lei
authors: L
authors: Chen
authors: Department of Thoracic Surgery, Renmin Hospital of Wuhan University, Wuhan, 430060 China.
authors: Shize
authors: S
authors: Pan
authors: Department of Thoracic Surgery, Renmin Hospital of Wuhan University, Wuhan, 430060 China.
authors: Hao
authors: H
authors: Hu
authors: Department of Thoracic Surgery, Renmin Hospital of Wuhan University, Wuhan, 430060 China.
authors: Qing
authors: Q
authors: Geng
keywords: Lung cancer stem cells (LCSCs); MicroRNAs (miRNAs)