title: Tzumin A and B, two new lignan derivatives from the barks of Sassafras tzumu.
abstract: Two new lignan compounds, 5'-allyl-2,2'-dihydroxy-[1,1'-biphenyl]-5-carboxylic acid (1) and 4,4'-diallyl-[1,1'-biphenyl]-2,2'-diol (2), together with four known compounds (3-6), were isolated from the barks of Sassafras tzumu. The new compounds were determined by NMR (1H and13C NMR, HSQC, HMBC,1H-1H COSY, NOESY/ROESY), and MS analysis. Compounds 1-3 showed potent AChE inhibitory activities, with IC50values of 2.00, 1.81 and 1.91 μM, respectively.
authors: a Department of Pharmaceutical Engineering , College of Biology & Pharmacy, Yulin Normal University , Yulin , P. R. China.|b Guangxi Key Laboratory of Farm Products Processing (Cultivation Base) , Yulin Normal University , Yulin , P. R. China.
authors: Haixiao
authors: H
authors: Lu
authors: a Department of Pharmaceutical Engineering , College of Biology & Pharmacy, Yulin Normal University , Yulin , P. R. China.
authors: Feiyan
authors: F
authors: Wu
authors: a Department of Pharmaceutical Engineering , College of Biology & Pharmacy, Yulin Normal University , Yulin , P. R. China.
authors: Meixiao
authors: M
authors: Jiang
authors: b Guangxi Key Laboratory of Farm Products Processing (Cultivation Base) , Yulin Normal University , Yulin , P. R. China.
authors: Weijiang
authors: W
authors: Liang
mesh_terms: D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry; D027441:Sassafras / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D002800:Cholinesterase Inhibitors; D017705:Lignans; D010936:Plant Extracts; C000616755:tzumin A; C000616774:tzumin B
keywords: AChE inhibitory activities; Sassafras tzumu; lignan