title: Biological Activity of Coumarin Derivatives as Anti-Leishmanial Agents.
abstract: Cutaneous leishmaniasis affects nearly 0.7 to 1.3 million people annually. Treatment of this disease is difficult due to lack of appropriate medication and the growing problem of drug resistance. Natural compounds such as coumarins serve as complementary therapeutic agents in addition to the current treatment modalities. In this study, we have performed an in-silico screening of the coumarin derivatives and their anti-leishmanial properties has been explored both in-vitro and in-vivo. One of the compounds (compound 2) exhibited leishmanicidal activity and to further study its properties, nanoliposomal formulation of the compound was developed. Treatment of cutaneous lesions in BALB/c mice with compound 2 showed significantly reduced lesion size as compared to the untreated mice (p<0.05) suggesting that compound 2 may possess anti-leishmanial properties.
authors: National Centre for Cell Science, NCCS Complex, SP Pune University Campus, Ganeshkhind, Pune, India.
authors: Vineetha
authors: V
authors: Mandlik
authors: Department of Chemistry, Indian Institute of Science Education and Research (IISER), Pune, Pashan, Pune, India.
authors: Sohan
authors: S
authors: Patil
authors: National Centre for Cell Science, NCCS Complex, SP Pune University Campus, Ganeshkhind, Pune, India.
authors: Ramanamurthy
authors: R
authors: Bopanna
authors: Department of Chemistry, Indian Institute of Science Education and Research (IISER), Pune, Pashan, Pune, India.
authors: Sudipta
authors: S
authors: Basu
authors: National Centre for Cell Science, NCCS Complex, SP Pune University Campus, Ganeshkhind, Pune, India.
authors: Shailza
authors: S
authors: Singh
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002460:Cell Line; D003374:Coumarins / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D016773:Leishmaniasis, Cutaneous / Q000188:drug therapy*; D008081:Liposomes; D053078:Membrane Potential, Mitochondrial / Q000187:drug effects; D051379:Mice; D008807:Mice, Inbred BALB C
chemical_list: D000981:Antiprotozoal Agents; D003374:Coumarins; D008081:Liposomes