title: Bioinorganic Nanohybrid Catalyst for Multistep Synthesis of Acetaminophen, an Analgesic.
abstract: A bioinorganic nanohybrid catalyst was synthesized by combining esterase with a platinum nanoparticle (PtNP). The combination of two catalysts resulted in enhanced catalytic activities, esterase hydrolysis, and hydrogenation in PtNPs, as compared to each catalyst alone. This hybrid catalyst can be successfully used in the multistep synthesis of acetaminophen (paracetamol), an analgesic and antipyretic drug, in a one-pot reaction with high yield and efficacy within a short time, demonstrating that the nanobiohybrid catalyst offers advantages in the synthesis of fine chemicals in industrial applications.
authors: Sungkyunkwan Advanced Institute of Nanotechnology, Sungkyunkwan University , Suwon 440-746, Korea.|Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine , Suwon 440-746, Korea.
authors: Boi Hoa
authors: BH
authors: San
authors: Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine , Suwon 440-746, Korea.
authors: Subramaniyam
authors: S
authors: Ravichandran
authors: Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine , Suwon 440-746, Korea.
authors: Kwang-Su
authors: KS
authors: Park
authors: Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine , Suwon 440-746, Korea.
authors: Vinod Kumar
authors: VK
authors: Subramani
authors: Sungkyunkwan Advanced Institute of Nanotechnology, Sungkyunkwan University , Suwon 440-746, Korea.|Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine , Suwon 440-746, Korea.
authors: Kyeong Kyu
authors: KK
authors: Kim
mesh_terms: D000082:Acetaminophen / Q000737:chemistry*; D000700:Analgesics; D002384:Catalysis; D006865:Hydrogenation; D010984:Platinum
chemical_list: D000700:Analgesics; D000082:Acetaminophen; D010984:Platinum
keywords: acetaminophen; bioinorganic nanohybrid; catalysis; esterase; hydrogenation; hydrolysis; platinum nanoparticle