title: Effects of remote ischemic preconditioning on acute myocardial injury in patients undergoing valve replacement.
abstract: BACKGROUND
  This study investigated the effects of remote ischemic preconditioning (RIPC) on acute myocardial injury and clinical outcome in adult patients undergoing valve replacement surgery.
  
  
  METHODS
  Sixty-three adult patients scheduled for elective valve replacement undergoing cardiopulmonary bypass (CPB) were randomly assigned to control or remote ischemic preconditioning treatment. RIPC was applied beginning with the first surgical incision by three times of inflating the cuff to 200 mmHg for 5 min, followed by 5 min of deflation. The plasma creatine kinase-MB (CK-MB) and cardiac troponin I (cTnI) were determined. The preoperative, intraoperative, and postoperative characteristics, and hemodynamics values were recorded during the study.
  
  
  RESULTS
  There were no significant differences in patient preoperative, intraoperative, and postoperative characteristics and hemodynamics values between groups. The activity of CK-MB and cTnI was significantly lower in RIPC group than CON group at 4 and 48 h after aortic unclamping.
  
  
  CONCLUSIONS
  The present study demonstrated that remote ischemic preconditioning might reduce release of CK-MB and cTnI in patients undergoing valve replacement. However, RIPC does not improve the clinical outcome of these patients.
authors: Department of Cardiac Surgery, Affiliated Province Hospital of Anhui Medical University, Hefei, 230001, China.
authors: Z
authors: Z
authors: Cao
authors: Department of Cardiac Surgery, Affiliated Province Hospital of Anhui Medical University, Hefei, 230001, China.
authors: R
authors: R
authors: Shen
authors: Department of Cardiac Surgery, Affiliated Province Hospital of Anhui Medical University, Hefei, 230001, China.
authors: X
authors: X
authors: Zhang
authors: Department of Cardiac Surgery, Affiliated Province Hospital of Anhui Medical University, Hefei, 230001, China.
authors: G
authors: G
authors: Cheng
authors: Department of Cardiac Surgery, Affiliated Province Hospital of Anhui Medical University, Hefei, 230001, China. anhuixzwk@163.com.
authors: Z
authors: Z
authors: Yan
mesh_terms: D000208:Acute Disease; D002315:Cardiopulmonary Bypass / Q000009:adverse effects* / Q000379:methods; D005260:Female; D006350:Heart Valve Prosthesis / Q000009:adverse effects*; D006801:Humans; D019157:Ischemic Preconditioning, Myocardial / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000473:pathology*
keywords: Ischemia–reperfusion injury; Myocardial; Remote ischemic preconditioning; Valve