title: CRUSADE bleeding score as a predictor of bleeding events in patients with acute coronary syndrome in Zagazig University Hospital.
abstract: OBJECTIVE
  To examine the value of CRUSADE bleeding score in predicting bleeding events in our local patients with acute coronary syndrome (ACS) in Zagazig University Hospitals.
  
  
  METHODS
  Our study included 240 patients with ACS. They underwent history and clinical examination; 12-lead electrocardiography; echocardiography; troponin I, hematocrit value; estimated glomerular filtration rate (eGFR); application of CRUSADE score; and follow-up of the hospital stay and documentations of events. Patients were classified into two groups: Group I: patients with major bleeding, and Group II: patients without major bleeding.
  
  
  RESULTS
  Patients with major bleeding were significantly older, with more diabetic and hypertensive patients, more prior vascular disease, heart failure, and less patients with unstable angina, higher heart rate and systolic blood, lower eGFR, and higher CRUSADE risk score. CRUSADE bleeding score was the strongest predictor of major bleeding. Sensitivity of CRUSADE score ≥33 in prediction of major bleeding in the whole study group was 80%, specificity was 73.4%, positive predictive value was 26.9%, negative predictive value was 96.9%, overall accuracy was 74.1%. Sensitivity of CRUSADE score ≥38.5 in prediction of major bleeding in the STEMI patients was 70%, specificity was 84.8%, positive predictive value was 50%, negative predictive value was 92.9%, and overall accuracy was 82.1%.
  
  
  CONCLUSIONS
  CRUSADE score is a good predictor for major bleeding in Egyptian patients with ACS. It is applicable in UA/NSTEMI as well as in STEMI patients and in women as well as in men.
authors: Cardiology Department, Faculty of Medicine, Zagazig University, Egypt. Electronic address: m_daydamony@hotmail.com.
authors: Mohamed M
authors: MM
authors: Al-Daydamony
authors: Cardiology Department, Faculty of Medicine, Zagazig University, Egypt.
authors: El-Sayed M
authors: EM
authors: Farag
mesh_terms: D054058:Acute Coronary Syndrome / Q000150:complications* / Q000453:epidemiology / Q000628:therapy; D000328:Adult; D000368:Aged; D004534:Egypt / Q000453:epidemiology; D004562:Electrocardiography; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D005500:Follow-Up Studies; D006400:Hematocrit; D006470:Hemorrhage / Q000139:chemically induced / Q000175:diagnosis* / Q000453:epidemiology; D017052:Hospital Mortality / Q000639:trends; D006785:Hospitals, University; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D062645:Percutaneous Coronary Intervention; D011379:Prognosis; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors
chemical_list: D005343:Fibrinolytic Agents
keywords: Acute coronary syndrome; CRUSADE bleeding risk score; Coronary artery disease; Egypt; Major bleeding