title: Collaborative effects of wavefront shaping and optical clearing agent in optical coherence tomography.
abstract: We demonstrate that simultaneous application of optical clearing agents (OCAs) and complex wavefront shaping in optical coherence tomography (OCT) can provide significant enhancement of penetration depth and imaging quality. OCA reduces optical inhomogeneity of a highly scattering sample, and the wavefront shaping of illumination light controls multiple scattering, resulting in an enhancement of the penetration depth and signal-to-noise ratio. A tissue phantom study shows that concurrent applications of OCA and wavefront shaping successfully operate in OCT imaging. The penetration depth enhancement is further demonstrated for <italic<ex vivo</italic< mouse ears, revealing hidden structures inaccessible with conventional OCT imaging.
authors: Korea Advanced Institute of Science and Technology, Department of Physics, 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Republic of KoreabKAIST Institute of Health Science and Technology, 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea.
authors: Hyeonseung
authors: H
authors: Yu
authors: KAIST Institute of Health Science and Technology, 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Republic of KoreacKorea Advanced Institute of Science and Technology, Department of Bio and Brain Engineering, 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea.
authors: Peter
authors: P
authors: Lee
authors: Korea Advanced Institute of Science and Technology, Department of Physics, 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Republic of KoreabKAIST Institute of Health Science and Technology, 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea.
authors: YoungJu
authors: Y
authors: Jo
authors: Korea Advanced Institute of Science and Technology, Department of Physics, 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Republic of KoreabKAIST Institute of Health Science and Technology, 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea.
authors: KyeoReh
authors: K
authors: Lee
authors: Saratov National Research State University, Research-Education Institute of Optics and Biophotonics, 83, Astrakhanskaya Street, Saratov 410012, RussiaeInstitute of Precision Mechanics and Control of Russian Academy of Sciences, Laboratory of Laser Diagnostics of Technical and Living Systems, 24, Rabochaya Street, Saratov 410028, RussiafNational Research Tomsk State University, Laboratory of Biophotonics, 36, Lenin's Avenue, Tomsk 634050, Russia.
authors: Valery V
authors: VV
authors: Tuchin
authors: KAIST Institute of Health Science and Technology, 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Republic of KoreacKorea Advanced Institute of Science and Technology, Department of Bio and Brain Engineering, 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea.
authors: Yong
authors: Y
authors: Jeong
authors: Korea Advanced Institute of Science and Technology, Department of Physics, 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Republic of KoreabKAIST Institute of Health Science and Technology, 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea.
authors: YongKeun
authors: Y
authors: Park
mesh_terms: D000818:Animals; D003287:Contrast Media; D004423:Ear / Q000000981:diagnostic imaging; D004867:Equipment Design; D005990:Glycerol; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D051379:Mice; D019047:Phantoms, Imaging; D015203:Reproducibility of Results; D041623:Tomography, Optical Coherence / Q000379:methods*
chemical_list: D003287:Contrast Media; D005990:Glycerol