title: Association between allergic conditions and risk of prostate cancer: A Prisma-Compliant Systematic Review and Meta-Analysis.
abstract: Association between allergic conditions and prostate cancer risk has been investigated for many years. However, the results from available evidence for the association are inconsistent. We conducted a meta-analysis to evaluate the relationship between allergic conditions (asthma, atopy, hay fever and "any allergy") and risk of prostate cancer. The PubMed and Embase databases were searched to screen observational studies meeting our meta-analysis criteria. Study selection and data extraction from included studies were independently performed by two authors. Twenty studies were considered eligible involving 5 case-control studies and 15 cohort studies. The summary relative risk (RR) for developing prostate cancer risk was 1.04 (95%CI: 0.92-1.17) for asthma, and 1.25 (95%CI: 0.74-2.10) for atopy, 1.04 (95%CI: 0.99-1.09) for hay fever, 0.96 (95%CI: 0.86-1.06) for any allergy. In the Subgroup and sensitivity analysis, similar results were produced. Little evidence of publication bias was observed. The present meta-analysis of observational studies indicates that no indication of an association between allergic conditions and risk of prostate cancer was found, and the meta-analysis does not support neither the original hypothesis of an overall cancer protective effect of allergic conditions, nor that of an opposite effect in the development of prostate cancer.
authors: Department of Urology, Guangdong Key Laboratory of Clinical Molecular Medicine and Diagnostics, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou 510180, China.|Urology Key Laboratory of Guangdong Province, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, 510230, China.|Department of Urology, Guizhou Provincial People's Hospital, Guizhou, 550002, China.
authors: Jianguo
authors: J
authors: Zhu
authors: Department of oral and maxillofacial surgery, Guizhou Provincial People's Hospital, Guizhou, 550002, China.
authors: Jukun
authors: J
authors: Song
authors: Department of Urology, Guangdong Key Laboratory of Clinical Molecular Medicine and Diagnostics, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou 510180, China.|Urology Key Laboratory of Guangdong Province, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, 510230, China.
authors: Zezhen
authors: Z
authors: Liu
authors: Department of Respiratory &Critical Care medicine, Guizhou Provincial People's Hospital, Guizhou, 550002, China.
authors: Jin
authors: J
authors: Han
authors: Department of Urology, Guangdong Key Laboratory of Clinical Molecular Medicine and Diagnostics, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou 510180, China.|Urology Key Laboratory of Guangdong Province, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, 510230, China.
authors: Heng
authors: H
authors: Luo
authors: College of Agricultural and Environmental Sciences, University of California, Davis, CA 95616, USA.
authors: Yunlin
authors: Y
authors: Liu
authors: Department of Urology, Guangdong Key Laboratory of Clinical Molecular Medicine and Diagnostics, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou 510180, China.|Urology Key Laboratory of Guangdong Province, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, 510230, China.
authors: Zhenyu
authors: Z
authors: Jia
authors: Department of Urology, Guizhou Provincial People's Hospital, Guizhou, 550002, China.
authors: Yuanbo
authors: Y
authors: Dong
authors: Department of oral and maxillofacial surgery, Guizhou Provincial People's Hospital, Guizhou, 550002, China.
authors: Wei
authors: W
authors: Zhang
authors: Department of Urology, Guangdong Key Laboratory of Clinical Molecular Medicine and Diagnostics, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou 510180, China.|Urology Key Laboratory of Guangdong Province, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, 510230, China.
authors: Funeng
authors: F
authors: Jiang
authors: Department of Urology, Guangdong Key Laboratory of Clinical Molecular Medicine and Diagnostics, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou 510180, China.|Departments of Pathology and Urology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
authors: Chinlee
authors: C
authors: Wu
authors: Department of Urology, Guizhou Provincial People's Hospital, Guizhou, 550002, China.
authors: Zaolin
authors: Z
authors: Sun
authors: Department of Urology, Guangdong Key Laboratory of Clinical Molecular Medicine and Diagnostics, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou 510180, China.|Urology Key Laboratory of Guangdong Province, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, 510230, China.
authors: Weide
authors: W
authors: Zhong
mesh_terms: D016022:Case-Control Studies; D015331:Cohort Studies; D006801:Humans; D006967:Hypersensitivity / Q000150:complications* / Q000276:immunology; D006969:Hypersensitivity, Immediate / Q000150:complications; D008297:Male; D018448:Models, Immunological; D064887:Observational Studies as Topic; D011471:Prostatic Neoplasms / Q000209:etiology* / Q000276:immunology; D006255:Rhinitis, Allergic, Seasonal / Q000150:complications; D012307:Risk Factors