title: Undiscovered Physiology of Transcript and Protein Networks.
abstract: The past two decades have witnessed a rapid evolution in our ability to measure RNA and protein from biological systems. As a result, new principles have arisen regarding how information is processed in cells, how decisions are made, and the role of networks in biology. This essay examines this technological evolution, reviewing (and critiquing) the conceptual framework that has emerged to explain how RNA and protein networks control cellular function. We identify how future investigations into transcriptomes, proteomes, and other cellular networks will enable development of more robust, quantitative models of cellular behavior whilst also providing new avenues to use knowledge of biological networks to improve human health. © 2016 American Physiological Society. Compr Physiol 6:1851-1872, 2016.
authors: Department of Anesthesiology & Perioperative Medicine, David Geffen School of Medicine, University of California, Los Angeles, USA.
authors: Emma
authors: E
authors: Monte
authors: Department of Anesthesiology & Perioperative Medicine, David Geffen School of Medicine, University of California, Los Angeles, USA.
authors: Manuel
authors: M
authors: Rosa-Garrido
authors: Department of Anesthesiology & Perioperative Medicine, David Geffen School of Medicine, University of California, Los Angeles, USA.|Department of Medicine/Cardiology, David Geffen School of Medicine, University of California, Los Angeles, USA.|Department of Physiology, David Geffen School of Medicine, University of California, Los Angeles, USA.
authors: Thomas M
authors: TM
authors: Vondriska
authors: Department of Medicine/Cardiology, David Geffen School of Medicine, University of California, Los Angeles, USA.
authors: Jessica
authors: J
authors: Wang
mesh_terms: D000818:Animals; D006801:Humans; D011506:Proteins / Q000502:physiology*; D020543:Proteome; D012313:RNA / Q000502:physiology*; D017423:Sequence Analysis, RNA; D059467:Transcriptome
chemical_list: D011506:Proteins; D020543:Proteome; D012313:RNA