title: The first discovery of RNA interference by RNA restriction enzymes to inhibit protein synthesis.
abstract: In this article, I review how an RNA restriction enzyme, a highly sequence-specific endoribonuclease, was for the first time discovered in 2003 and how the concept of RNA interference using RNA restriction enzymes or mRNA interferases has been developed.
authors: Department of Biochemistry and Molecular Biology, Robert Wood Johnson Medical School, Center for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, NJ 08854, United States. Electronic address: Inouye@cabm.rutgers.edu.
authors: Masayori
authors: M
authors: Inouye
mesh_terms: D004268:DNA-Binding Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D004722:Endoribonucleases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D029968:Escherichia coli Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D014176:Protein Biosynthesis / Q000235:genetics*; D034622:RNA Interference
chemical_list: D004268:DNA-Binding Proteins; D029968:Escherichia coli Proteins; C422954:MazE protein, E coli; C422955:MazF protein, E coli; D004722:Endoribonucleases
keywords: E. coli; RNA interference; RNA restriction enzymes; Single-Protein Production (SPP)