title: Patch testing with hydroxyisohexyl 3-cyclohexene carboxaldehyde (HICC) - a multicentre study of the Swedish Contact Dermatitis Research Group.
abstract: BACKGROUND
  In 2014, the fragrance hydroxyisohexyl 3-cyclohexene carboxaldehyde (HICC) was excluded from the Swedish baseline series.
  
  
  OBJECTIVE
  To study (i) whether fragrance mix (FM) II with 5% HICC detects more positive reactions than usual FM II with 2.5% HICC, and (ii) the reproducibility of patch testing with HICC.
  
  
  METHODS
  Two thousand one hundred and eighteen dermatitis patients at five Swedish dermatology departments were consecutively tested with FM II 14% pet., FM II 16.5% pet., and duplicate preparations of HICC 5% pet.
  
  
  RESULTS
  Of the patients, 3.2% reacted to FM II 14%, and 1.5% reacted to HICC. Separate testing with HICC detected 0.3% reactions without concomitant reactivity to FM II. FM II with 5% HICC did not give rise to more irritant reactions or signs of active sensitization than FM II with 2.5% HICC. Patch testing with duplicate applications of HICC increased the overall prevalence of HICC contact allergy to 1.9%.
  
  
  CONCLUSIONS
  FM II with 5% HICC does not detect more positive reactions than FM II with 2.5% HICC. Separate testing with HICC does not detect a sufficient proportion of patients who react only to HICC, without concomitant reactions to FM II, to warrant its inclusion in a baseline series.
authors: Department of Occupational and Environmental Dermatology, Lund University, Skåne University Hospital, 205 02, Malmö, Sweden.
authors: Malin
authors: M
authors: Engfeldt
authors: Department of Dermatology, Sahlgrenska University Hospital, 413 45, Gothenburg, Sweden.
authors: Lina
authors: L
authors: Hagvall
authors: Department of Occupational and Environmental Dermatology, Lund University, Skåne University Hospital, 205 02, Malmö, Sweden.
authors: Marléne
authors: M
authors: Isaksson
authors: Unit of Occupational and Environmental Dermatology, Institute of Environmental Medicine, Karolinska Institute and Centre for Occupational and Environmental Medicine, 113 65, Stockholm, Sweden.
authors: Mihály
authors: M
authors: Matura
authors: Department of Occupational and Environmental Dermatology, Lund University, Skåne University Hospital, 205 02, Malmö, Sweden.
authors: Martin
authors: M
authors: Mowitz
authors: Department of Dermatology, Uddevalla Hospital, 451 80, Uddevalla, Sweden.
authors: Kristina
authors: K
authors: Ryberg
authors: Department of Public Health and Clinical Medicine, Dermatology & Venerology, Umeå University, 901 85, Umeå, Sweden.
authors: Berndt
authors: B
authors: Stenberg
authors: Department of Occupational and Environmental Dermatology, Lund University, Skåne University Hospital, 205 02, Malmö, Sweden.
authors: Cecilia
authors: C
authors: Svedman
authors: Department of Occupational and Environmental Dermatology, Lund University, Skåne University Hospital, 205 02, Malmö, Sweden.
authors: Magnus
authors: M
authors: Bruze
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000447:Aldehydes / Q000009:adverse effects*; D000485:Allergens / Q000009:adverse effects*; D002648:Child; D053138:Cyclohexenes / Q000009:adverse effects*; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010328:Patch Tests; D010476:Perfume / Q000009:adverse effects*; D015995:Prevalence; D015203:Reproducibility of Results; D013548:Sweden / Q000453:epidemiology; D055815:Young Adult
chemical_list: D000447:Aldehydes; D000485:Allergens; D053138:Cyclohexenes; D010476:Perfume; C092244:hydroxyisohexyl 3-cyclohexene carboxaldehyde
keywords: CAS no. 31906-04-4 / 51414-25-6; allergic contact dermatitis; contact allergy; delayed hypersensitivity; dose/area; fragrance; fragrance mix II; high-performance liquid chromatography; hydroxyisohexyl 3-cyclohexene carboxaldehyde