title: Relative efficacy of nicotinamide treatment of a mouse model of infantile Niemann-Pick C1 disease.
abstract: Nicotinamide delivered in drinking water at about 2 g/kg/day significantly prolonged survival and showed a suggestive improvement on memory in the Npc1nih/ Npc1nihmouse model of infantile NPC1 disease. It is likely that this role is due to its function as a histone deacetylase (HDAC) inhibitor although another HDAC inhibitor, valproic acid, was without effect. Nicotinamide could also work by preventing/reversing oxidative stress.
authors: Department of Pediatrics, University of Arizona, Tucson, AZ, 85724-5073, USA.
authors: Craig A
authors: CA
authors: Marshall
authors: Department of Pediatrics, University of Arizona, Tucson, AZ, 85724-5073, USA.|Department of Medicine, Mercy Hospital, St. Louis, MO, USA.
authors: Ivan A
authors: IA
authors: Borbon
authors: Department of Pediatrics, University of Arizona, Tucson, AZ, 85724-5073, USA. erickson@peds.arizona.edu.
authors: Robert P
authors: RP
authors: Erickson
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D056572:Histone Deacetylase Inhibitors / Q000494:pharmacology*; D051379:Mice; D008807:Mice, Inbred BALB C; D009536:Niacinamide / Q000494:pharmacology*; D052556:Niemann-Pick Disease, Type C / Q000188:drug therapy*; D018384:Oxidative Stress; D014635:Valproic Acid / Q000494:pharmacology
chemical_list: D056572:Histone Deacetylase Inhibitors; D009536:Niacinamide; D014635:Valproic Acid
keywords: Histone deacetylase; Nicotinamide; Niemann-Pick C1 disease; Oxidative stress; Sirtuin; Valproic acid