title: Decreased resting state metabolic activity in frontopolar and parietal brain regions is associated with suicide plans in depressed individuals.
abstract: Suicide plans are a major risk factor for suicide, which is a devastating outcome of depression. While structural and functional brain changes have been demonstrated in relation to suicidal thoughts and behaviour, brain mechanisms underlying suicide plans have not yet been studied. Here, we studied changes in regional cerebral metabolic activity in association with suicide plans in depressed individuals. Using18FDG-PET, a comparative study of regional cerebral glucose metabolism (rCMRglu) was carried out in depressed individuals with suicidal thoughts and suicide plans, depressed individuals with only suicidal thoughts, depressed individuals without suicide thoughts and plans, and healthy controls. When compared to the other groups, depressed individuals with suicide plans showed relative hypometabolism in the right middle frontal gyrus and the right inferior parietal lobe (Brodmann areas 10 and 39). Suicide plans in depressed individuals appear to be associated with reduced activity in brain areas that are involved in decision-making and choice, more particularly in exploratory behaviour.
authors: Ghent University, Department of Psychiatry and Medical Psychology, Unit for Suicide Research, Ghent, Belgium. Electronic address: cornelis.vanheeringen@ugent.be.
authors: Kees
authors: K
authors: van Heeringen
authors: Ghent University, Department of Psychiatry and Medical Psychology, Unit for Suicide Research, Ghent, Belgium; Key Laboratory of Cognition and Personality, Faculty of Psychology, Southwest University, Chongqing, China.
authors: Guo-Rong
authors: GR
authors: Wu
authors: Ghent University, Department of Psychiatry and Medical Psychology, Unit for Suicide Research, Ghent, Belgium.
authors: Myriam
authors: M
authors: Vervaet
authors: Ghent University, Department of Psychiatry and Medical Psychology, Unit for Suicide Research, Ghent, Belgium; Faculty of Medicine and Pharmacy, Free University Brussels, Brussels, Belgium; Ghent University, Ghent Experimental Psychiatry (GHEP) Lab, Ghent, Belgium.
authors: Marie-Anne
authors: MA
authors: Vanderhasselt
authors: Ghent University, Department of Psychiatry and Medical Psychology, Unit for Suicide Research, Ghent, Belgium; Ghent University, Ghent Experimental Psychiatry (GHEP) Lab, Ghent, Belgium; Department of Psychiatry, Free University Brussels, Brussels, Belgium.
authors: Chris
authors: C
authors: Baeken
mesh_terms: D000328:Adult; D001931:Brain Mapping; D015897:Comorbidity; D003657:Decision Making / Q000502:physiology; D003866:Depressive Disorder / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000378:metabolism* / Q000523:psychology; D005260:Female; D019788:Fluorodeoxyglucose F18; D005625:Frontal Lobe / Q000000981:diagnostic imaging / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D007406:Interview, Psychological; D008297:Male; D008875:Middle Aged; D010296:Parietal Lobe / Q000000981:diagnostic imaging / Q000378:metabolism*; D049268:Positron-Emission Tomography; D011569:Psychiatric Status Rating Scales; D019275:Radiopharmaceuticals; D012146:Rest; D059020:Suicidal Ideation; D011795:Surveys and Questionnaires
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D005947:Glucose
keywords: Decision-making; Depression; Frontopolar; PET; Prefrontal; Suicide