title: Biological voyage of solid lipid nanoparticles: a proficient carrier in nanomedicine.
abstract: This review projects the prospects and issues faced by solid lipid nanoparticles (SLNs) in current scenarios, specially related to its clinical implementation and effectiveness. We re-examine the basic concept of biobehavior and movement of SLNs as a nanomedicine carrier. The extensive survey of the uptake and absorption mechanism from different routes, distribution pattern, targeting efficiency, effect of surface functionalization on biodistribution, elimination pathways and toxic effects have been documented. In general, the objective of this review is to boost our knowledge about the interaction of SLNs with the bioenvironment, their movement in, and effect on, a living system and future prospects.
authors: Department of Pharmaceutical Sciences & Technology, Birla Institute of Technology, Mesra, Ranchi- 835 215, Jharkhand, India.
authors: Hasan
authors: H
authors: Ali
authors: Department of Pharmaceutical Sciences & Technology, Birla Institute of Technology, Mesra, Ranchi- 835 215, Jharkhand, India.
authors: Sandeep Kumar
authors: SK
authors: Singh
mesh_terms: D000818:Animals; D004333:Drug Administration Routes; D004337:Drug Carriers / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics*; D006801:Humans; D008055:Lipids / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics*; D050997:Nanomedicine / Q000379:methods*; D053758:Nanoparticles / Q000008:administration & dosage* / Q000009:adverse effects / Q000378:metabolism*; D014018:Tissue Distribution
chemical_list: D004337:Drug Carriers; D008055:Lipids
keywords: biofate; nanomedicine; solid lipid nanoparticles