title: Inflammation after Ischemic Stroke: The Role of Leukocytes and Glial Cells.
abstract: The immune response after stroke is known to play a major role in ischemic brain pathobiology. The inflammatory signals released by immune mediators activated by brain injury sets off a complex series of biochemical and molecular events which have been increasingly recognized as a key contributor to neuronal cell death. The primary immune mediators involved are glial cells and infiltrating leukocytes, including neutrophils, monocytes and lymphocyte. After ischemic stroke, activation of glial cells and subsequent release of pro- and anti-inflammatory signals are important for modulating both neuronal cell damage and wound healing. Infiltrated leukocytes release inflammatory mediators into the site of the lesion, thereby exacerbating brain injury. This review describes how the roles of glial cells and circulating leukocytes are a double-edged sword for neuroinflammation by focusing on their detrimental and protective effects in ischemic stroke. Here, we will focus on underlying characterize of glial cells and leukocytes under inflammation after ischemic stroke.
authors: Department of Anatomy, Yonsei University College of Medicine, Seoul 03722, Korea.
authors: Jong Youl
authors: JY
authors: Kim
authors: Department of Anatomy, Yonsei University College of Medicine, Seoul 03722, Korea.; Bk21 Plus Project for Medical Sciences and Brain Research Institute, Yonsei University College of Medicine, Seoul 03722, Korea.
authors: Joohyun
authors: J
authors: Park
authors: Department of Anatomy, Yonsei University College of Medicine, Seoul 03722, Korea.
authors: Ji Young
authors: JY
authors: Chang
authors: Department of Clinical Laboratory Science, Semyung University, Jaecheon 27136, Korea.
authors: Sa-Hyun
authors: SH
authors: Kim
authors: Department of Anatomy, Yonsei University College of Medicine, Seoul 03722, Korea.; Bk21 Plus Project for Medical Sciences and Brain Research Institute, Yonsei University College of Medicine, Seoul 03722, Korea.
authors: Jong Eun
authors: JE
authors: Lee
keywords: glial cells; inflammation; ischemic stroke; leukocytes