title: New family of antimicrobial agents derived from 1,4-naphthoquinone.
abstract: Naphthalene-1,4-dione derivatives were synthesized and tested against selected bacterial strains. All the tested compounds were prepared by direct introduction of corresponding substituents into the naphthoquinone core in oxidative conditions. In this study, eight strains of bacteria (Proteus, Escherichia, Klebsiella, Staphylococcus, Enterobacter, Pseudomonas, Salmonella, Enterococcus) were used for determination of antimicrobial activity of synthesized compounds with the Minimal Inhibitory Concentration (MIC) method. Additionally, selected compounds were tested for haemolytic activity using human erythrocytes. All naphthalene-1,4-dione derivatives exhibited significant antimicrobial activity with MIC values between 7.8 and 500 μg/ml. A majority of the synthesized compounds showed the strongest antibacterial properties towards S. aureus, with a high level of selectivity. None of the tested naphthalene-1,4-dione derivatives exhibited haemolytic activity.
authors: Department of Molecular Biology, Institute of Biotechnology, The John Paul II Catholic University of Lublin, ul. Konstantynów 1i, 20-708 Lublin, Poland.
authors: Monika
authors: M
authors: Janeczko
authors: Organic Chemistry Department, Faculty of Chemistry, Maria Curie-Skłodowska University, ul. Gliniana 33, 20-614 Lublin, Poland.
authors: Oleg M
authors: OM
authors: Demchuk
authors: Organic Chemistry Department, Faculty of Chemistry, Maria Curie-Skłodowska University, ul. Gliniana 33, 20-614 Lublin, Poland.
authors: Dorota
authors: D
authors: Strzelecka
authors: Department of Molecular Biology, Institute of Biotechnology, The John Paul II Catholic University of Lublin, ul. Konstantynów 1i, 20-708 Lublin, Poland.
authors: Konrad
authors: K
authors: Kubiński
authors: Department of Molecular Biology, Institute of Biotechnology, The John Paul II Catholic University of Lublin, ul. Konstantynów 1i, 20-708 Lublin, Poland. Electronic address: maciekm@kul.pl.
authors: Maciej
authors: M
authors: Masłyk
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity; D001419:Bacteria / Q000187:drug effects; D015195:Drug Design; D004912:Erythrocytes / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D009285:Naphthoquinones / Q000737:chemistry* / Q000494:pharmacology* / Q000633:toxicity
chemical_list: D000900:Anti-Bacterial Agents; D009285:Naphthoquinones; C035342:1,4-naphthoquinone
keywords: Antimicrobial; Haemolysis; Naphthoquinones; Staphylococcus aureus