title: DrugCentral: online drug compendium.
abstract: DrugCentral (http://drugcentral.org) is an open-access online drug compendium. DrugCentral integrates structure, bioactivity, regulatory, pharmacologic actions and indications for active pharmaceutical ingredients approved by FDA and other regulatory agencies. Monitoring of regulatory agencies for new drugs approvals ensures the resource is up-to-date. DrugCentral integrates content for active ingredients with pharmaceutical formulations, indexing drugs and drug label annotations, complementing similar resources available online. Its complementarity with other online resources is facilitated by cross referencing to external resources. At the molecular level, DrugCentral bridges drug-target interactions with pharmacological action and indications. The integration with FDA drug labels enables text mining applications for drug adverse events and clinical trial information. Chemical structure overlap between DrugCentral and five online drug resources, and the overlap between DrugCentral FDA-approved drugs and their presence in four different chemical collections, are discussed. DrugCentral can be accessed via the web application or downloaded in relational database format.
authors: Translational Informatics Division, Department of Internal Medicine, The University of New Mexico Health Science Center, Albuquerque, NM 87131, USA.
authors: Oleg
authors: O
authors: Ursu
authors: Translational Informatics Division, Department of Internal Medicine, The University of New Mexico Health Science Center, Albuquerque, NM 87131, USA.
authors: Jayme
authors: J
authors: Holmes
authors: Department of Computer Science, University of New Mexico, Albuquerque, NM 87131, USA.
authors: Jeffrey
authors: J
authors: Knockel
authors: Translational Informatics Division, Department of Internal Medicine, The University of New Mexico Health Science Center, Albuquerque, NM 87131, USA.
authors: Cristian G
authors: CG
authors: Bologa
authors: Translational Informatics Division, Department of Internal Medicine, The University of New Mexico Health Science Center, Albuquerque, NM 87131, USA.
authors: Jeremy J
authors: JJ
authors: Yang
authors: Translational Informatics Division, Department of Internal Medicine, The University of New Mexico Health Science Center, Albuquerque, NM 87131, USA.
authors: Stephen L
authors: SL
authors: Mathias
authors: Translational Informatics Division, Department of Internal Medicine, The University of New Mexico Health Science Center, Albuquerque, NM 87131, USA.
authors: Stuart J
authors: SJ
authors: Nelson
authors: Translational Informatics Division, Department of Internal Medicine, The University of New Mexico Health Science Center, Albuquerque, NM 87131, USA toprea@salud.unm.edu.
authors: Tudor I
authors: TI
authors: Oprea
mesh_terms: D062313:Databases, Pharmaceutical; D017277:Drug Approval; D004339:Drug Compounding; D004347:Drug Interactions; D004348:Drug Labeling; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D004364:Pharmaceutical Preparations / Q000737:chemistry; D057386:Search Engine; D014481:United States; D014486:United States Food and Drug Administration; D064878:Web Browser
chemical_list: D004364:Pharmaceutical Preparations