title: Seizure due to multiple drugs intoxication: a case report.
abstract: The mechanism of the antidepressant effect of bupropion is not fully understood. Besides, using it in the treatment of depression, it is found to be effective in reducing withdrawal symptoms due to smoking cessation. A 28-year-old female patient with a history of depression was admitted to emergency department an hour after ingestion of bupropion, quetiapine, and levothyroxine in high doses to commit suicide. While accepting her into the Intensive Care Unit, she was awake, alert, disoriented and agitated. After 2h, the patient had a generalized tonic-clonic seizure. The necessary treatment was given and 9h later with hemodynamic improvement, the patients' mental status improved. Bupropion may cause unusual behaviors such as delusions, paranoia, hallucinations, or confusion. The risk of seizure is strongly dose-dependent. We want to emphasize the importance of early gastric lavage and administration of activated charcoal.
authors: Kecioren Training Hospital, Ankara, Turkey. Electronic address: handandrhandan@yahoo.com.tr.
authors: Handan
authors: H
authors: Gulec
authors: Kecioren Training Hospital, Ankara, Turkey.
authors: Munire
authors: M
authors: Babayigit
authors: Kecioren Training Hospital, Ankara, Turkey.
authors: Aysun
authors: A
authors: Kurtay
authors: Kecioren Training Hospital, Ankara, Turkey.
authors: Mehmet
authors: M
authors: Sahap
authors: Kecioren Training Hospital, Ankara, Turkey.
authors: Fatma
authors: F
authors: Ulus
authors: Kecioren Training Hospital, Ankara, Turkey.
authors: Zehra
authors: Z
authors: Tutal
authors: Kecioren Training Hospital, Ankara, Turkey.
authors: Eyup
authors: E
authors: Horasanli
mesh_terms: D000328:Adult; D018687:Antidepressive Agents, Second-Generation / Q000506:poisoning*; D014150:Antipsychotic Agents / Q000506:poisoning; D016642:Bupropion / Q000506:poisoning*; D004830:Epilepsy, Tonic-Clonic / Q000139:chemically induced; D005260:Female; D006801:Humans; D000069348:Quetiapine Fumarate / Q000506:poisoning; D012640:Seizures / Q000139:chemically induced*; D013406:Suicide, Attempted; D013974:Thyroxine / Q000506:poisoning
chemical_list: D018687:Antidepressive Agents, Second-Generation; D014150:Antipsychotic Agents; D016642:Bupropion; D000069348:Quetiapine Fumarate; D013974:Thyroxine
keywords: Bupripion; Bupropiona; Convulsão; Intensive care unit; Seizure; Unidade de terapia intensiva