title: Nanoscale upconversion for oxygen sensing.
abstract: Optical oxygen sensors have many promising qualities but rely on excitation by violet or blue wavelengths that suffer from high levels of scattering and absorption in biological tissues. Here we demonstrate an alternative method using 980nm near-infrared light to initially stimulate ceramic upconverting nanoparticles (UCNPs) contained within a novel form, electrospun core-shell fibers. The emission of the UCNPs excites a molecular optical oxygen sensor, the subsequent phosphorescent emission being dynamically quenched by the presence of molecular oxygen. The potential for use of such an energy transfer within electrospun fibers widely used in biological applications is promising. However, current knowledge of such 'handshake' interactions is limited. Fiber-based carriers enabling such optical conversions provide unique opportunities for biosensing as they recapitulate the topography of the extracellular matrix. This creates a wide array of potential theranostic, fiber-based applications in disease diagnosis/imaging, drug delivery and monitoring of therapeutic response. Using a fiber-based vehicle, we observed gaseous oxygen sensing capabilities and a linear Stern-Volmer response allowing highly accurate calibration. Configurational aspects were also studied to determine how to maximize the efficiency of this 'handshake' interaction.
authors: Materials Science and Engineering, The Ohio State University, Columbus, OH 43210, USA.
authors: Kayla
authors: K
authors: Presley
authors: Materials Science and Engineering, The Ohio State University, Columbus, OH 43210, USA.
authors: Jinwoo
authors: J
authors: Hwang
authors: School of Chemistry, UNSW Australia, Sydney, NSW 2052, Australia.
authors: Soshan
authors: S
authors: Cheong
authors: School of Chemistry, UNSW Australia, Sydney, NSW 2052, Australia.
authors: Richard
authors: R
authors: Tilley
authors: Intelligent Material Solutions, Inc., Princeton, NJ 08540, USA.
authors: Josh
authors: J
authors: Collins
authors: Neuroscience and Physiology, State University of New York Upstate Medical University, Syracuse, NY 13210, USA.
authors: Mariano
authors: M
authors: Viapiano
authors: Materials Science and Engineering, The Ohio State University, Columbus, OH 43210, USA. Electronic address: lannutti.1@osu.edu.
authors: John
authors: J
authors: Lannutti
mesh_terms: D004583:Electrons; D008163:Luminescent Measurements; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010100:Oxygen / Q000032:analysis*; D038761:Photobleaching; D013816:Thermodynamics; D013997:Time Factors
chemical_list: D010100:Oxygen
keywords: Electrospinning; In vivo oxygen sensing; Polycaprolactone; Polysulfone; Upconversion; Upconverting nanoparticles