title: Effect of interstimulus interval on cortical proprioceptive responses to passive finger movements.
abstract: Shortening of the interstimulus interval (ISI) generally leads to attenuation of cortical sensory responses. For proprioception, however, this ISI effect is still poorly known. Our aim was to characterize the ISI dependence of movement-evoked proprioceptive cortical responses and to find the optimum ISI for proprioceptive stimulation. We measured, from 15 healthy adults, magnetoencephalographic responses to passive flexion and extension movements of the right index finger. The movements were generated by a movement actuator at fixed ISIs of 0.5, 1, 2, 4, 8, and 16 s, in separate blocks. The responses peaked at ~ 70 ms (extension) and ~ 90 ms (flexion) in the contralateral primary somatosensory cortex. The strength of the cortical source increased with the ISI, plateauing at the 8-s ISI. Modeling the ISI dependence with an exponential saturation function revealed response lifetimes of 1.3 s (extension) and 2.2 s (flexion), implying that the maximum signal-to-noise ratio (SNR) in a given measurement time is achieved with ISIs of 1.7 s and 2.8 s respectively. We conclude that ISIs of 1.5-3 s should be used to maximize SNR in recordings of proprioceptive cortical responses to passive finger movements. Our findings can benefit the assessment of proprioceptive afference in both clinical and research settings.
authors: Department of Neuroscience and Biomedical Engineering, Aalto University, PO Box 12200, 00076, Aalto, Espoo, Finland.|Aalto NeuroImaging, Aalto University, 00076, Aalto, Espoo, Finland.
authors: Eero
authors: 0000-0002-5084-7635
authors: E
authors: Smeds
authors: Department of Neuroscience and Biomedical Engineering, Aalto University, PO Box 12200, 00076, Aalto, Espoo, Finland.
authors: Harri
authors: H
authors: Piitulainen
authors: Department of Neuroscience and Biomedical Engineering, Aalto University, PO Box 12200, 00076, Aalto, Espoo, Finland.|BCBL, Basque Center on Cognition, Brain and Language, 20009, San Sebastian, Spain.
authors: Mathieu
authors: M
authors: Bourguignon
authors: Department of Neuroscience and Biomedical Engineering, Aalto University, PO Box 12200, 00076, Aalto, Espoo, Finland.|Aalto NeuroImaging, Aalto University, 00076, Aalto, Espoo, Finland.
authors: Veikko
authors: V
authors: Jousmäki
authors: Department of Neuroscience and Biomedical Engineering, Aalto University, PO Box 12200, 00076, Aalto, Espoo, Finland.|Department of Art, Aalto University, PO Box 31000, 00076, Aalto, Helsinki, Finland.
authors: Riitta
authors: R
authors: Hari
mesh_terms: D000328:Adult; D001931:Brain Mapping; D005073:Evoked Potentials, Somatosensory / Q000502:physiology*; D005260:Female; D005385:Fingers / Q000502:physiology*; D006801:Humans; D015225:Magnetoencephalography / Q000379:methods; D008297:Male; D009068:Movement / Q000502:physiology*; D011434:Proprioception / Q000502:physiology*; D011930:Reaction Time; D013003:Somatosensory Cortex / Q000502:physiology*
keywords: humans; magnetoencephalography; muscle stretch receptors; primary somatosensory cortex; proprioception