title: Diagnostic evaluation of appendiceal orifice inflammation in ulcerative colitis.
abstract: OBJECTIVE
  To evaluate the diagnostic significance of appendiceal orifice inflammation (AOI) in ulcerative colitis (UC) patients.
  
  
  METHODS
  We retrospectively examined data from patients with colitis from May 2010 to January 2014 and assigned them to two groups: UC cases and specific colitis cases. First, we clarified the difference in the AOI+ rate between the two groups. Thereafter, imaging findings of all the patients with colitis were re-examined. Features of AOI alone or in combination with proctitis (referred to as "combination features") were considered as the two separate diagnostic criteria for diagnosing UC. By comparing the current diagnoses with the previous diagnoses, evaluation indexes were obtained.
  
  
  RESULTS
  A total of 3582 colitis cases (UC cases: 427; specific colitis cases: 3155) were examined. The mean AOI+ rates in UC and specific colitis cases were 26.2% and 0.7%, respectively; a Chi-squared test indicated that the difference between these rates was statistically significant (x2=6.81; p<0.001, OR=50.99). When the AOI features alone were used to diagnose UC, the sensitivity was 26.2% [95% confidence interval (CI), 22.3%-30.6%], agreement rate was 90.6%, and specificity was 99.3% (95% CI, 98.9%-99.5%). When the combination features were used to diagnose UC, the sensitivity was 26.2% (95% CI, 22.3%-30.6%), agreement rate was 91.1%, and specificity was 99.9% (95% CI, 99.7%-100%).
  
  
  CONCLUSIONS
  Combining AOI features and proctitis may lead to a more effective UC diagnosis and enable physicians to identify this condition more promptly among miscellaneous diseases.
authors: Department of Internal Medicine, the Affiliated Taihe Hospital of Hubei University, Hubei, China. chenxing8181@163.com.
authors: Da Qin
authors: DQ
authors: Zhan
authors: Xing
authors: X
authors: Chen
authors: Rong
authors: R
authors: Wang
authors: Jing
authors: J
authors: Zhang
authors: Dan Yu
authors: DY
authors: Zhao
authors: Shu Jing
authors: SJ
authors: Zhang
authors: Zhi Feng
authors: ZF
authors: Wang
authors: Rui Jun
authors: RJ
authors: Ma
authors: Bo
authors: B
authors: Hou
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001064:Appendicitis / Q000175:diagnosis* / Q000209:etiology; D001065:Appendix / Q000000981:diagnostic imaging* / Q000473:pathology; D016009:Chi-Square Distribution; D002648:Child; D003092:Colitis / Q000150:complications / Q000175:diagnosis / Q000473:pathology; D003093:Colitis, Ulcerative / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011349:Proctitis / Q000175:diagnosis / Q000209:etiology; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D055815:Young Adult