title: JAK-STAT Signaling Jump Starts the Hair Cycle.
abstract: Legrand et al show that JAK/STAT5 signaling in the dermal papilla is required for anagen onset in the murine hair cycle. Interestingly, others have shown that JAK-inhibition is able to induce telogen-to-anagen transition in wild-type mice. This apparent contradiction highlights the complexity of interactions within the hair follicle, and encourages further discussion on the role of JAK-STAT signaling in the various stem cell niches of the hair follicle.
authors: Department of Dermatology, Columbia University, New York, New York, USA. Electronic address: ew2445@cumc.columbia.edu.
authors: Etienne
authors: E
authors: Wang
authors: Department of Dermatology, Columbia University, New York, New York, USA.
authors: Sivan
authors: S
authors: Harel
authors: Department of Dermatology, College of Physicians and Surgeons, Columbia University, New York, New York, USA. Electronic address: amc65@cumc.columbia.edu.
authors: Angela M
authors: AM
authors: Christiano
mesh_terms: D000818:Animals; D002453:Cell Cycle; D005786:Gene Expression Regulation; D006201:Hair Diseases / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D018859:Hair Follicle / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D053612:Janus Kinases / Q000096:biosynthesis / Q000235:genetics*; D050799:STAT5 Transcription Factor / Q000096:biosynthesis / Q000235:genetics*; D015398:Signal Transduction
chemical_list: D050799:STAT5 Transcription Factor; D053612:Janus Kinases