title: Oropouche virus is detected in peripheral blood leukocytes from patients.
abstract: Oropouche virus (OROV) is a frequent cause of arboviral febrile disease in the Amazon. The present report describes studies done in two patients, one of them; the first OROV human case acquired outside of the Amazon, which have revealed for the first time the presence of OROV in peripheral blood leukocytes. This novel finding raises important issues regarding pathogenesis of human infections and may offer a new tool, for the rapid diagnosis of this neglected infection. J. Med. Virol. 89:1108-1111, 2017. © 2017 Wiley Periodicals, Inc.
authors: Department of Cell and Molecular Biology, Virology Research Center, Ribeirao Preto School of Medicine, University of Sao Paulo, Ribeirao Preto, São Paulo, Brazil.
authors: Luciano Kleber
authors: LK
authors: de Souza Luna
authors: Department of Cell and Molecular Biology, Virology Research Center, Ribeirao Preto School of Medicine, University of Sao Paulo, Ribeirao Preto, São Paulo, Brazil.
authors: Alcir Humberto
authors: AH
authors: Rodrigues
authors: Department of Cell and Molecular Biology, Virology Research Center, Ribeirao Preto School of Medicine, University of Sao Paulo, Ribeirao Preto, São Paulo, Brazil.
authors: Rodrigo Ivo Marques
authors: RI
authors: Santos
authors: Department of Biochemistry and Immunology, University of Sao Paulo School of Medicine, Ribeirao Preto, São Paulo, Brazil.
authors: Renata
authors: R
authors: Sesti-Costa
authors: Department of Cell and Molecular Biology, Virology Research Center, Ribeirao Preto School of Medicine, University of Sao Paulo, Ribeirao Preto, São Paulo, Brazil.
authors: Miriã Ferreira
authors: MF
authors: Criado
authors: Department of Cell and Molecular Biology, Virology Research Center, Ribeirao Preto School of Medicine, University of Sao Paulo, Ribeirao Preto, São Paulo, Brazil.
authors: Ronaldo B
authors: RB
authors: Martins
authors: Department of Cell and Molecular Biology, Virology Research Center, Ribeirao Preto School of Medicine, University of Sao Paulo, Ribeirao Preto, São Paulo, Brazil.
authors: Maria Lúcia
authors: ML
authors: Silva
authors: Department of Internal Medicine, Virology Research Center, University of Sao Paulo School of Medicine, Ribeirao Preto, São Paulo, Brazil.
authors: Luana Sella
authors: LS
authors: Delcaro
authors: Department of Cell and Molecular Biology, Virology Research Center, Ribeirao Preto School of Medicine, University of Sao Paulo, Ribeirao Preto, São Paulo, Brazil.
authors: Jose Luiz
authors: JL
authors: Proença-Modena
authors: Department of Internal Medicine, Virology Research Center, University of Sao Paulo School of Medicine, Ribeirao Preto, São Paulo, Brazil.
authors: Luiz Tadeu Moraes
authors: LT
authors: Figueiredo
authors: Department of Cell and Molecular Biology, Virology Research Center, Ribeirao Preto School of Medicine, University of Sao Paulo, Ribeirao Preto, São Paulo, Brazil.
authors: Gustavo Olszanski
authors: GO
authors: Acrani
authors: Department of Cell and Molecular Biology, Virology Research Center, Ribeirao Preto School of Medicine, University of Sao Paulo, Ribeirao Preto, São Paulo, Brazil.
authors: Eurico
authors: E
authors: Arruda
mesh_terms: D000293:Adolescent; D000818:Animals; D002044:Bunyaviridae Infections / Q000821:virology*; D005260:Female; D006801:Humans; D007962:Leukocytes / Q000821:virology*; D008297:Male; D008875:Middle Aged; D016851:Orthobunyavirus / Q000302:isolation & purification*
keywords: Oropouche virus; peripheral blood leukocytes; viremia