title: The diagnostic value of soluble urokinase plasminogen activator receptor (suPAR) compared to C-reactive protein (CRP) and procalcitonin (PCT) in children with systemic inflammatory response syndrome (SIRS).
abstract: BACKGROUND
  The aim of the present study was to determine the diagnostic and prognostic values of suPAR and to compare them to CRP and PCT in pediatric patients with systemic inflammatory response syndrome (SIRS).
  
  
  METHODS
  A prospective case-control study was performed.The study was performed in a tertiary university hospital which has a 649-bed capacity. Patients included 27 children with SIRS and 27 control subjects without any infection or immunosuppressive condition. Blood samples were obtained on the day of admission and on the 4-7th days of the hospital stay.
  
  
  RESULTS
  The median (min-max) serum levels of suPAR obtained on the first day of the admission were 10.06 (2.7-57.46) and 2.22 (1.08-5.13) ng/Ml for the SIRS group and control group, respectively. The median serum levels of suPAR in the SIRS group was significantly higher than that in the control group (p < 0.05). The serum suPAR levels was significantly higher in nonsurvivors than in survivors in SIRS group (p < 0.05). In the SIRS group, the area under the receiver operating characteristics curve (AUCROC) for suPAR revealed an optimum cut-off value, sensitivity, specificity, NPV and PPV of 0.978, 3.8 ng/mL, 96%, 96%, 96%, and 96%, respectively.
  
  
  CONCLUSIONS
  We conclude that suPAR does have diagnostic value in children with SIRS. Additionally, persistent high serum suPAR level predicts mortality in SIRS in children.
authors: Marmara University School of Medicine, Department of Pediatrics, Division of Pediatric Infectious Diseases, Istanbul, Turkey.
authors: Melis
authors: M
authors: Şirinoğlu
authors: Marmara University School of Medicine, Department of Pediatrics, Division of Pediatric Infectious Diseases, Istanbul, Turkey. Electronic address: asoysal@marmara.edu.tr.
authors: Ahmet
authors: A
authors: Soysal
authors: Marmara University School of Medicine, Department of Pediatrics, Division of Pediatric Infectious Diseases, Istanbul, Turkey.
authors: Ayşe
authors: A
authors: Karaaslan
authors: Marmara University School of Medicine, Department of Pediatrics, Division of Pediatric Infectious Diseases, Istanbul, Turkey.
authors: Eda
authors: E
authors: Kepenekli Kadayifci
authors: Marmara University School of Medicine, Department of Pediatrics, Division of Pediatric Intensive Care Unit, Istanbul, Turkey.
authors: Nilüfer
authors: N
authors: Yalındağ-Öztürk
authors: Marmara University School of Medicine, Department of Anesthesiology and Reanimation, Istanbul, Turkey.
authors: İsmail
authors: İ
authors: Cinel
authors: Marmara University School of Medicine, Department of Biochemistry, Istanbul, Turkey.
authors: Ali
authors: A
authors: Yaman
authors: Marmara University School of Medicine, Department of Biochemistry, Istanbul, Turkey.
authors: Goncagül
authors: G
authors: Haklar
authors: Marmara University School of Medicine, Department of Biochemistry, Istanbul, Turkey.
authors: Önder
authors: Ö
authors: Şirikci
authors: Marmara University School of Medicine, Department of Pediatrics, Division of Pediatric Endocrinology, Istanbul, Turkey.
authors: Serap
authors: S
authors: Turan
authors: Marmara University School of Medicine, Department of Microbiology, Istanbul, Turkey.
authors: Gülşen
authors: G
authors: Altınkanat Gelmez
authors: Marmara University School of Medicine, Department of Microbiology, Istanbul, Turkey.
authors: Güner
authors: G
authors: Söyletir
authors: Marmara University School of Medicine, Department of Pediatrics, Division of Pediatric Infectious Diseases, Istanbul, Turkey.
authors: Mustafa
authors: M
authors: Bakır
mesh_terms: D002097:C-Reactive Protein / Q000378:metabolism*; D002116:Calcitonin / Q000097:blood*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D011379:Prognosis; D011446:Prospective Studies; D011498:Protein Precursors / Q000097:blood; D012372:ROC Curve; D055293:Receptors, Urokinase Plasminogen Activator / Q000097:blood*; D012680:Sensitivity and Specificity; D018746:Systemic Inflammatory Response Syndrome / Q000097:blood / Q000175:diagnosis* / Q000378:metabolism
chemical_list: D011498:Protein Precursors; D055293:Receptors, Urokinase Plasminogen Activator; D002116:Calcitonin; D002097:C-Reactive Protein
keywords: Children; SIRS; Soluble urokinase plasminogen activator receptor