title: Compulsive sexual behavior: Prefrontal and limbic volume and interactions.
abstract: Compulsive sexual behaviors (CSB) are relatively common and associated with significant personal and social dysfunction. The underlying neurobiology is still poorly understood. The present study examines brain volumes and resting state functional connectivity in CSB compared with matched healthy volunteers (HV).
  
  
  
  Structural MRI (MPRAGE) data were collected in 92 subjects (23 CSB males and 69 age-matched male HV) and analyzed using voxel-based morphometry. Resting state functional MRI data using multi-echo planar sequence and independent components analysis (ME-ICA) were collected in 68 subjects (23 CSB subjects and 45 age-matched HV).
  
  
  
  CSB subjects showed greater left amygdala gray matter volumes (small volume corrected, Bonferroni adjusted P < 0.01) and reduced resting state functional connectivity between the left amygdala seed and bilateral dorsolateral prefrontal cortex (whole brain, cluster corrected FWE P < 0.05) compared with HV.
  
  
  
  CSB is associated with elevated volumes in limbic regions relevant to motivational salience and emotion processing, and impaired functional connectivity between prefrontal control regulatory and limbic regions. Future studies should aim to assess longitudinal measures to investigate whether these findings are risk factors that predate the onset of the behaviors or are consequences of the behaviors. Hum Brain Mapp 38:1182-1190, 2017. © 2016 Wiley Periodicals, Inc.
authors: Department of Psychiatry, University of Cambridge, Herchel Smith Buidling for Brain & Mind Sciences, Forvie Site, Robinson Way, Cambridge, CB2 0SZ, United Kingdom.|Cognitive Neuroscience Research Unit, Danish Neuroscience Center, Aarhus University Hospital, Nørrebrogade 44, building 10G, 8000, Aarhus C, Denmark.|Center of Functionally Integrative Neuroscience/MINDLab, Danish Neuroscience Center, Aarhus University Hospital, Nørrebrogade 44, building, 10G, 8000, Aarhus C, Denmark.
authors: Casper
authors: 0000-0001-6290-2040
authors: C
authors: Schmidt
authors: Department of Psychiatry, University of Cambridge, Herchel Smith Buidling for Brain & Mind Sciences, Forvie Site, Robinson Way, Cambridge, CB2 0SZ, United Kingdom.|Behavioral and Clinical Neurosciences Institute, Department of Psychology, University of Cambridge, Downing Street, Cambridge, CB2, 3EB, United Kingdom.
authors: Laurel S
authors: LS
authors: Morris
authors: Department of Psychiatry, University of Cambridge, Herchel Smith Buidling for Brain & Mind Sciences, Forvie Site, Robinson Way, Cambridge, CB2 0SZ, United Kingdom.|Cognitive Neuroscience Research Unit, Danish Neuroscience Center, Aarhus University Hospital, Nørrebrogade 44, building 10G, 8000, Aarhus C, Denmark.|Center of Functionally Integrative Neuroscience/MINDLab, Danish Neuroscience Center, Aarhus University Hospital, Nørrebrogade 44, building, 10G, 8000, Aarhus C, Denmark.
authors: Timo L
authors: TL
authors: Kvamme
authors: United Kingdom Council for Psychotherapy, 2nd Floor, Edward House 2 Wakley Street, London, EC1V 7LT, United Kingdom.
authors: Paula
authors: P
authors: Hall
authors: United Kingdom Council for Psychotherapy, 2nd Floor, Edward House 2 Wakley Street, London, EC1V 7LT, United Kingdom.
authors: Thaddeus
authors: T
authors: Birchard
authors: Department of Psychiatry, University of Cambridge, Herchel Smith Buidling for Brain & Mind Sciences, Forvie Site, Robinson Way, Cambridge, CB2 0SZ, United Kingdom.|Behavioral and Clinical Neurosciences Institute, Department of Psychology, University of Cambridge, Downing Street, Cambridge, CB2, 3EB, United Kingdom.|Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge Rd, Fulbourn, Cambridge, CB21 5HH, United Kingdom.
authors: Valerie
authors: V
authors: Voon
mesh_terms: D000328:Adult; D001931:Brain Mapping; D016022:Case-Control Studies; D003192:Compulsive Behavior / Q000209:etiology / Q000473:pathology / Q000821:virology; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D008032:Limbic System / Q000000981:diagnostic imaging / Q000503:physiopathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D017397:Prefrontal Cortex / Q000000981:diagnostic imaging / Q000503:physiopathology*; D012146:Rest; D012725:Sexual Behavior / Q000502:physiology*; D055815:Young Adult
keywords: compulsive sexual behavior; depression; resting state functional MRI; sexual addiction; voxel-based morphometry