title: [Application of multidisciplinary treatment in patients with liver metastasis of colorectal cancer].
abstract: OBJECTIVE
  To evaluate the application of multidisciplinary treatment (MDT) in patients with liver metastasis of colorectal cancer(CLM).
  
  
  METHODS
  Clinical data of 118 patients with liver metastasis of colorectal cancer, including 32 patients with MDT (MDT group) and 86 patients without MDT (control group), from February 2014 to April 2015 in PLA General Hospital were analyzed retrospectively. Compliance of preoperative examination and adjuvant therapy, and efficacy-associated indexes were compared between the two groups.
  
  
  RESULTS
  (1) As compared to control group, statistically significant increase in imaging examination ratio was found in MDT group: chest CT [87.5%(28/32) vs. 40.7%(35/86), P=0.0000], abdominal MRI [84.4%(27/32) vs.61.6%(53/86), P=0.019], pelvic MRI [63.7%(7/11) vs. 24.3%(8/33), P=0.017]. The preoperative assessment of TNM staging was also higher in MDT group [100%(32/32) vs. 20.9%(18/86), P=0.0000], while there was no significant difference in accuracy rate of TNM staging between the two groups [81.3%(26/32) vs. 66.7%(12/18), P=0.2465]. (2) Rates of preoperative chemotherapy and chemotherapy completion were also higher in MDT group than those in control group [90.6%(29/32) vs. 62.8%(54/86), P=0.0033; 82.8% (24/29) vs. 57.4% (31/54), P=0.000], but conversion rate of unresectable CLM showed no significant difference [24.0% (6/25) vs. 14.3% (7/49), P=0.299 ]. (3) Rate of one-stage resection or ablation was higher in MDT group compared to control group [76.9%(10/13) vs. 36.0%(9/25), P=0.038], and resection rate of metastasis nidus was also higher in MDT group [77.0%(20/26) vs. 44.9%(13/29), P=0.015]. No significant differences were observed in rates of R0 resection, positive surgical margin, lymph node clearance, ablation of metastasis nidus, pathological complete response, postoperative chemotherapy or postoperative complications (all P>0.05).
  
  
  CONCLUSIONS
  MDT has the advantages on standardization of preoperative examination and perioperative chemotherapy, and can improve the rate of one-stage resection or ablation, as well as resection of metastasis nidus.
authors: Team of Aviation Medical Examination, Air Force General Hospital, Beijing 100142, China.
authors: Hao
authors: H
authors: Li
authors: Department of General Surgery, PLA General Hospital, Beijing 100853, China. duxiaohui301@sina.com.
authors: Xiaohui
authors: X
authors: Du
authors: Department of General Surgery, PLA General Hospital, Beijing 100853, China.
authors: Shaoyou
authors: S
authors: Xia
authors: Department of General Surgery, PLA General Hospital, Beijing 100853, China.
authors: Songyan
authors: S
authors: Li
authors: Department of General Surgery, PLA General Hospital, Beijing 100853, China.
authors: Jian
authors: J
authors: Xu
authors: Department of General Surgery, PLA General Hospital, Beijing 100853, China.
authors: Guijun
authors: G
authors: Zou
authors: Department of General Surgery, PLA General Hospital, Beijing 100853, China.
authors: Shidong
authors: S
authors: Hu
mesh_terms: D000368:Aged; D015179:Colorectal Neoplasms / Q000473:pathology*; D003131:Combined Modality Therapy; D005260:Female; D006498:Hepatectomy; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary* / Q000628:therapy*; D008198:Lymph Nodes; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011183:Postoperative Complications; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome