title: Synergistic thermoradiotherapy based on PEGylated Cu3BiS3ternary semiconductor nanorods with strong absorption in the second near-infrared window.
abstract: In this work, we report a successful synthesis of copper bismuth sulfide nanorods (NRs) with broad and strong photoabsorption ranging from ultraviolet (UV) to near-infrared (NIR) wavelengths, which can be used as a 1064 nm-laser-driven photothermal agent with the photothermal conversion efficiency of 40.7%, noticeably higher than most of the reported PTT agents working in NIR-II window. The as-prepared PEGylated Cu3BiS3NRs were used as photoacoustic imaging (PAI) and CT imaging agents due to their strong NIR absorption and large X-ray attenuation coefficient of bismuth. We are the first to demonstrate that a small quantity of PEGylated Cu3BiS3NRs in tumors can concentrate radiation energy and trigger mild PTT under NIR-II irradiation and thus, these particles could be used as a novel, synergistic thermoradiotheraputic agent that enhances the efficacy of radiotherapy.
authors: State Key Lab of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, PR China.
authors: Ang
authors: A
authors: Li
authors: The First People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong University, 100 Haining Road, Shanghai 200080, PR China.
authors: Xiang
authors: X
authors: Li
authors: State Key Lab of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, PR China.
authors: Xujiang
authors: X
authors: Yu
authors: State Key Lab of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, PR China.
authors: Wei
authors: W
authors: Li
authors: The First People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong University, 100 Haining Road, Shanghai 200080, PR China.
authors: Ruyi
authors: R
authors: Zhao
authors: The First People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong University, 100 Haining Road, Shanghai 200080, PR China. Electronic address: 54andromeda@163.com.
authors: Xiao
authors: X
authors: An
authors: Institute of Nano Biomedicine and Engineering, Key Laboratory of Thin Film and Microfabrication Technology of Ministry of Education, Department of Instrument Science and Engineering, School of Electronic Information and Electrical Engineering, National Center for Translational Medicine, Collaborative Innovational Center for System Biology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, PR China.
authors: Daxiang
authors: D
authors: Cui
authors: Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, MD 20892, USA.
authors: Xiaoyuan
authors: X
authors: Chen
authors: State Key Lab of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, PR China. Electronic address: wwli@sjtu.edu.cn.
authors: Wanwan
authors: W
authors: Li
mesh_terms: D065638:Absorption, Radiation; D000818:Animals; D045744:Cell Line, Tumor; D003131:Combined Modality Therapy / Q000379:methods*; D006979:Hyperthermia, Induced / Q000379:methods*; D007259:Infrared Rays / Q000627:therapeutic use; D053768:Metal Nanoparticles / Q000737:chemistry / Q000627:therapeutic use* / Q000648:ultrastructure; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D043942:Nanotubes / Q000737:chemistry*; D009374:Neoplasms, Experimental / Q000473:pathology / Q000628:therapy*; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000627:therapeutic use; D011092:Polyethylene Glycols / Q000737:chemistry*; D012666:Semiconductors; D016896:Treatment Outcome
chemical_list: D017319:Photosensitizing Agents; D011092:Polyethylene Glycols
keywords: Copper bismuth sulfide; Multimodel imaging; Nanorods; The second near-infrared (NIR-II) window; Thermoradiotherapy