title: The effects of mosquito saliva on dengue virus infectivity in humans.
abstract: Arboviruses such as Dengue, Chikungunya, and Zika viruses represent a major public health problem due to globalization and propagation of susceptible vectors worldwide. Arthropod vector-derived salivary factors have the capacity to modulate human cells function by enhancing or suppressing viral replication and, therefore, modify the establishment of local and systemic viral infection. Here, we discuss how mosquito saliva may interfere with Dengue virus (DENV) infection in humans. Identification of saliva factors that enhance infectivity will allow the production of vector-based vaccines and therapeutics that would interfere with viral transmission by targeting arthropod saliva components. Understanding the role of salivary proteins in DENV transmission will provide tools to control not only Dengue but also other arboviral diseases transmitted by the same vectors.
authors: Laboratory of MIVEGEC, UMR 224 IRD/CNRS/UM1, Montpellier, France.
authors: Sineewanlaya
authors: S
authors: Wichit
authors: Laboratory of MIVEGEC, UMR 224 IRD/CNRS/UM1, Montpellier, France.
authors: Pauline
authors: P
authors: Ferraris
authors: Environment and Infectious Risks Unit, Pasteur Institute, Paris, France.
authors: Valérie
authors: V
authors: Choumet
authors: Laboratory of MIVEGEC, UMR 224 IRD/CNRS/UM1, Montpellier, France. Electronic address: dorothee.misse@ird.fr.
authors: Dorothée
authors: D
authors: Missé
mesh_terms: D000818:Animals; D009033:Culicidae / Q000821:virology*; D003715:Dengue / Q000635:transmission*; D003716:Dengue Virus / Q000472:pathogenicity*; D018562:Disease Transmission, Infectious; D054884:Host-Pathogen Interactions; D006801:Humans; D012463:Saliva / Q000378:metabolism*