title: The effect of consuming small volumes of beer on gastric motility and the involvement of gene polymorphisms.
abstract: The aim of this study was to investigate the effect of consuming small amounts of beer or a nonalcoholic beer taste beverage (non-beer) on gastric emptying and the polymorphisms in alcohol metabolism-related enzyme-encoding genes. Twenty male healthy volunteers were questioned regarding their alcohol consumption status, and body measurement was performed. The genetic polymorphisms in ADH1B (rs1229984, Arg47His) and ALDH2 (rs671 Glu487Lys) were analyzed. The subjects consumed 150 mL of beer or non-beer once per week, followed by the ingestion of 200 kcal of the test nutrient containing13C-acetate 15 min later, after which the subjects' exhalations were collected up to 120 min. The concentration peak of13C was measured as Tmax. Diamine oxidase (DAO) activity for the marker of small intestinal function activity was also measured the day after the test. Gastric emptying was significantly slower in the group that consumed a small amount of beer, and in daily beer consumption group, and also in the ADH1B *2/*2, ALDH2 *1/*2 genotypes compared to non-beer drinking group. DAO values were not significantly changed between beer and non-beer group. The consumption of even a small amount of beer and the polymorphisms in ADH1B / ALDH2 affects gastric motility.
authors: Department of Gastroenterology, Fujita Health University.
authors: Tomoyuki
authors: T
authors: Shibata
authors: Hiromi
authors: H
authors: Yamashita
authors: Tomohiko
authors: T
authors: Kawamura
authors: Yasutaka
authors: Y
authors: Jodai
authors: Takafumi
authors: T
authors: Omori
authors: Kazuya
authors: K
authors: Sumi
authors: Yuichiro
authors: Y
authors: Ichikawa
authors: Masaaki
authors: M
authors: Okubo
authors: Takamitsu
authors: T
authors: Ishizuka
authors: Tomomitsu
authors: T
authors: Tahara
authors: Mitsuo
authors: M
authors: Nagasaka
authors: Yoshihito
authors: Y
authors: Nakagawa
authors: Ichiro
authors: I
authors: Hirata
authors: Naoki
authors: N
authors: Ohmiya
authors: Makoto
authors: M
authors: Nakao
mesh_terms: D000328:Adult; D000426:Alcohol Dehydrogenase / Q000235:genetics; D000428:Alcohol Drinking / Q000235:genetics*; D000071396:Aldehyde Dehydrogenase, Mitochondrial / Q000235:genetics; D001515:Beer; D001944:Breath Tests; D003605:D-Amino-Acid Oxidase / Q000097:blood / Q000378:metabolism; D004789:Enzyme Activation; D005769:Gastrointestinal Motility; D056726:Genetic Association Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011795:Surveys and Questionnaires; D055815:Young Adult
chemical_list: C489332:ADH1B protein, human; D000426:Alcohol Dehydrogenase; D000071396:Aldehyde Dehydrogenase, Mitochondrial; D003605:D-Amino-Acid Oxidase