title: Primary cardiac B cell lymphoma: Manifestation of Felty's syndrome or TNFα antagonist.
abstract: Primary cardiac B cell lymphoma is rare. To date, fewer than 90 cases have been described in the literature. We report a 67-year-old woman with a 30-year history of rheumatoid arthritis, who had received treatment with leflunomide for 10 years and infliximab for 2 years. Secondary Felty's syndrome appeared. She was admitted to the hospital for abdominal pain. Investigations disclosed a 5cm cardiac mass in the right atrium. Histopathologic examination of tissue specimens obtained at surgical myocardial biopsy demonstrated primary cardiac B cell lymphoma. The other iatrogenic lymphoproliferative disorders are reviewed. This lesion might be a manifestation of long term TNFα antagonists treatment.
authors: Department of Pathology, Amiens University Hospital, France. Electronic address: nazim.benz@gmail.com.
authors: Nazim
authors: N
authors: Benzerdjeb
authors: Department of Radiology, Amiens University Hospital, France.
authors: Fatima
authors: F
authors: Ameur
authors: Department of Pathology, Amiens University Hospital, France.
authors: Jean-Fortune
authors: JF
authors: Ikoli
authors: Department of Pathology, Amiens University Hospital, France.
authors: Henri
authors: H
authors: Sevestre
mesh_terms: D000368:Aged; D018501:Antirheumatic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D005258:Felty Syndrome / Q000150:complications* / Q000473:pathology; D005260:Female; D006338:Heart Neoplasms / Q000209:etiology* / Q000473:pathology; D006801:Humans; D000069285:Infliximab / Q000009:adverse effects* / Q000627:therapeutic use; D007555:Isoxazoles / Q000009:adverse effects / Q000627:therapeutic use; D000077339:Leflunomide; D016393:Lymphoma, B-Cell / Q000209:etiology* / Q000473:pathology; D009206:Myocardium / Q000473:pathology; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors
chemical_list: D018501:Antirheumatic Agents; D007555:Isoxazoles; D014409:Tumor Necrosis Factor-alpha; D000069285:Infliximab; D000077339:Leflunomide
keywords: Cardiac lymphoma; Felty’s syndrome; Infliximab; Rheumatoid arthritis