title: Roles of PECAM-1 in cell function and disease progression.
abstract: Platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31) belongs to immunoglobulin superfamily, which is key factor for adhesion and accumulation of platelets. It is proved that PECAM-1 is closely correlative with cell migration, proliferation, apoptosis, signal transduction and cellular immunity. Meanwhile, PECAM-1 involves in multiple clinical diseases, such as atherosclerosis, thrombosis and leukemia. This paper reviewed the structure and function of PECAM-1, and its roles in cell function and disease generation and progression.
authors: Department of Hematology, Second Affiliated Hospital, Third Military Medical University, Chongqing, China. yimeifeng@163.com.
authors: Y-M
authors: YM
authors: Feng
authors: X-H
authors: XH
authors: Chen
authors: X
authors: X
authors: Zhang
mesh_terms: D050197:Atherosclerosis; D001792:Blood Platelets; D002465:Cell Movement; D018450:Disease Progression; D006801:Humans; D007938:Leukemia; D019408:Platelet Endothelial Cell Adhesion Molecule-1; D015398:Signal Transduction; D013927:Thrombosis
chemical_list: D019408:Platelet Endothelial Cell Adhesion Molecule-1