title: The impact of androgen deprivation on artificial urinary sphincter outcomes.
abstract: BACKGROUND
  Androgen deprivation therapy (ADT) causes systemic tissue atrophy. It is unclear if this tissue atrophy adversely impacts artificial urinary sphincter (AUS) outcomes. We sought to evaluate the effect of ADT on adverse AUS outcomes.
  
  
  METHODS
  We retrospectively identified 518 men undergoing primary AUS placement at our institution between 1998 and 2014. Rates of device explant for infection/erosion, mechanical failure, and urethral atrophy in men with >6 months of ADT use within 2 years prior to AUS placement were compared to ADT naive men.
  
  
  RESULTS
  Fifty of the patients (50/518, 9.7%) had >6 months of ADT use within 2 years prior to AUS placement while 442 were ADT naive. Multivariable survival analysis of AUS events by competing risks failed to show any effect of ADT on device explantation for infection/erosion (HR 1.12, P=0.68), replacement for mechanical failure (HR 0.92, P=0.77), or urethral atrophy (HR 0.77, P=0.46).
  
  
  CONCLUSIONS
  This study did not show evidence supporting differences in adverse AUS outcomes between men with ADT use and ADT naive men.
authors: Department of Urology, Mayo Clinic, Rochester, Minnesota, USA.
authors: George C
authors: GC
authors: Bailey
authors: Department of Urology, Mayo Clinic, Rochester, Minnesota, USA.
authors: Brian J
authors: BJ
authors: Linder
authors: Department of Urology, Mayo Clinic, Rochester, Minnesota, USA.
authors: Marcelino E
authors: ME
authors: Rivera
authors: Department of Urology, Mayo Clinic, Rochester, Minnesota, USA.
authors: Matthew J
authors: MJ
authors: Ziegelmann
authors: Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.
authors: Laureano J
authors: LJ
authors: Rangel
authors: Department of Urology, Mayo Clinic, Rochester, Minnesota, USA.
authors: Daniel S
authors: DS
authors: Elliott
keywords: Antiandrogen; artificial urinary sphincter (AUS); incontinence; outcomes