title: Zika virus infection and Guillain-Barré syndrome: a review focused on clinical and electrophysiological subtypes.
abstract: In 2016, we have seen a rapid emergence of Zika virus-associated Guillain-Barré syndrome (GBS) since its first description in a French-Polynesian patient in 2014. Current evidence estimates the incidence of GBS at 24 cases per 100 000 persons infected by Zika virus. This will result in a sharp rise in the number of GBS cases worldwide with the anticipated global spread of Zika virus. A better understanding of the pathogenesis of Zika-associated GBS is crucial to prepare us for the current epidemic. In this review, we evaluate the existing literature on GBS in association with Zika and other flavivirus to better define its clinical subtypes and electrophysiological characteristics, demonstrating a demyelinating subtype of GBS in most cases. We also recommend measures that will help reduce the gaps in knowledge that currently exist.
authors: Department of Neuroscience, Imaging and Clinical Sciences, University 'G. d'Annunzio' Chieti-Pescara, Chieti, Italy.
authors: Antonino
authors: A
authors: Uncini
authors: Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
authors: Nortina
authors: N
authors: Shahrizaila
authors: Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan.
authors: Satoshi
authors: 0000-0002-4716-8578
authors: S
authors: Kuwabara
mesh_terms: D004196:Disease Outbreaks; D055724:Electrophysiological Phenomena; D020275:Guillain-Barre Syndrome / Q000145:classification / Q000453:epidemiology / Q000503:physiopathology*; D006801:Humans; D015994:Incidence; D000071244:Zika Virus / Q000302:isolation & purification; D000071243:Zika Virus Infection / Q000453:epidemiology
keywords: GUILLAIN-BARRE SYNDROME; NEUROPATHY; NEUROPHYSIOL, CLINICAL