title: Manipulation of novel nano-prodrug composed of organic pigment-based hybrid network and its optical uses.
abstract: Here we developed the first case of pyropheophorbide-a-loaded PEGylated-hybrid carbon nanohorns (CNH-Pyro) to study tumor targeting therapy. During incubation with living cells, CNH-Pyro exhibited very intense red emissions. The intracellular imaging results were carried out by flow cytometry based on four different kinds of cell lines (including three adherent cell lines and one suspension cell line). Compared with free pyropheophorbide-a, CNH-Pyro demonstrated enhanced photodynamic tumor ablation efficiency during in vitro experiments due to improved biocompatibility of the hybrid nanomaterial and the photothermal therapy effect derived from carbon-network structure. Trypan blue staining experiments supported that the cell fate was dependent on the synergistic effects of both CNH-Pyro and laser irradiations. These results indicated that the chlorin-entrapped carbon nanohorns could provide powerful delivery vehicles for increasing photodynamic efficacy and possess early identification of the disease.
authors: College of Chemistry and Chemical Engineering, Henan Key Laboratory of Function-Oriented Porous Materials, Luoyang Normal University, Luoyang 471934, PR China.
authors: Zhan
authors: Z
authors: Zhou
authors: Key Laboratory of Theoretical Chemistry of Environment, Ministry of Education, School of Chemistry & Environment, South China Normal University, Guangzhou 510006, PR China.
authors: Yuhui
authors: Y
authors: Zheng
authors: Departments of Physiology and Developmental Biology, University of Texas, Southwestern Medical Center, Dallas, TX 75390-9133, USA.
authors: Cheng Zhang
authors: CZ
authors: Cheng
authors: Key Laboratory of Theoretical Chemistry of Environment, Ministry of Education, School of Chemistry & Environment, South China Normal University, Guangzhou 510006, PR China.
authors: Jiajia
authors: J
authors: Wen
authors: Key Laboratory of Theoretical Chemistry of Environment, Ministry of Education, School of Chemistry & Environment, South China Normal University, Guangzhou 510006, PR China; Guangzhou Key Laboratory of Materials for Energy Conversion and Storage, Guangzhou 510006, PR China. Electronic address: qmwang@scnu.edu.cn.
authors: Qianming
authors: Q
authors: Wang
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D002734:Chlorophyll / Q000031:analogs & derivatives* / Q000737:chemistry; D005434:Flow Cytometry; D006801:Humans; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry*; D055095:Optics and Photonics / Q000379:methods*; D011355:Prodrugs / Q000494:pharmacology*; D013050:Spectrometry, Fluorescence; D019265:Spectroscopy, Near-Infrared; D013194:Staining and Labeling
chemical_list: D011355:Prodrugs; D002734:Chlorophyll; C040298:pyropheophorbide a
keywords: Hybrid material; Photodynamic therapy; Photosensitizer