title: Stillbirth and intrauterine fetal death: role of routine histopathological placental findings to determine cause of death.
abstract: OBJECTIVE
  Placental abnormalities are a common cause of death in stillbirth, ranking second only to unexplained deaths, though there is wide variation in the proportion attributed to placental disease. In clinical practice, interpretation of the significance of placental findings is difficult, since many placental features in stillbirths overlap with those in live births. Our aim was to examine objectively classified placental findings from a series of > 1000 autopsies following intrauterine death in order to evaluate the role of placental histological examination in determining the cause of death.
  
  
  METHODS
  As part of a larger study evaluating several aspects of autopsy findings in intrauterine death, a dedicated database was used to collate antenatal and postmortem examination details for all cases examined between 2005 and 2013 at two tertiary specialist centers in London, UK. Histological findings for placentas were evaluated in relation to the final cause of death.
  
  
  RESULTS
  Among 1064 intrauterine deaths, 946 (89%) cases had the placenta submitted for examination as part of the autopsy. Of these, 307 (32%) cases had the cause of death assigned to abnormalities of the placenta, cord or membranes. Around one third of stillbirths (≥ 24 weeks) had some isolated placental histological abnormality identified, many of uncertain significance, a significantly greater proportion than in cases of second-trimester intrauterine fetal demise (P < 0.0001). The cause of death was ascending infection in 176/946 (19%) cases, peaking at 22 weeks' gestation, with significantly more black mothers having ascending infection compared with other ethnicities (P < 0.0001). Maternal vascular malperfusion was the largest category of placental abnormalities in stillbirth, with peak prevalence in the early third trimester. There were 18 (2%) cases with specific histological abnormalities, including chronic histiocytic intervillositis and massive perivillous fibrin deposition.
  
  
  CONCLUSIONS
  Placental pathologies represent the largest category of cause of intrauterine death. Placental histological examination is the single most useful component of the autopsy process in this clinical setting. A minority of cases are associated with specific placental pathologies, often with high recurrence rates, that can be diagnosed only on microscopic examination of the placenta. Many deaths remain unexplained, although placental histological lesions may be present which are of uncertain significance. A rigorous, systematic approach to placental pathology research and classification may yield better understanding of the significance of placental findings and reduce the rate of unexplained intrauterine deaths. Copyright © 2016 ISUOG. Published by John Wiley & Sons Ltd.
authors: Department of Histopathology, Camelia Botnar Laboratories, Great Ormond Street Hospital, London, UK.|University College London, Institute of Child Health, London, UK.
authors: J
authors: J
authors: Man
authors: Department of Histopathology, Camelia Botnar Laboratories, Great Ormond Street Hospital, London, UK.|University College London, Institute of Child Health, London, UK.
authors: J C
authors: JC
authors: Hutchinson
authors: Department of Obstetrics and Gynaecology, St Mary's Hospital, Manchester, UK.
authors: A E
authors: AE
authors: Heazell
authors: Department of Histopathology, Camelia Botnar Laboratories, Great Ormond Street Hospital, London, UK.
authors: M
authors: M
authors: Ashworth
authors: Department of Histopathology, St George's Hospital, London, UK.
authors: I
authors: I
authors: Jeffrey
authors: Department of Histopathology, Camelia Botnar Laboratories, Great Ormond Street Hospital, London, UK.|University College London, Institute of Child Health, London, UK.
authors: N J
authors: NJ
authors: Sebire
mesh_terms: D000293:Adolescent; D000328:Adult; D001344:Autopsy; D002423:Cause of Death; D005260:Female; D005313:Fetal Death / Q000209:etiology*; D005865:Gestational Age; D006801:Humans; D010920:Placenta / Q000002:abnormalities / Q000098:blood supply / Q000473:pathology*; D010922:Placenta Diseases / Q000401:mortality / Q000473:pathology*; D011247:Pregnancy; D050497:Stillbirth; D055815:Young Adult
keywords: histology; miscarriage; placenta; stillbirth