title: Inflammatory bowel disease is associated with an increased risk of inflammatory skin diseases: A population-based cross-sectional study.
abstract: BACKGROUND
  Inflammatory bowel disease (IBD) is a chronic disease of the gastrointestinal tract attributed to aberrant activity of the immune system. Increasing evidence suggests that patients with IBD are at an increased risk of inflammatory skin diseases (ISDs).
  
  
  OBJECTIVE
  We sought to clarify the association between IBD and ISDs using a nationwide health claims database maintained in Korea.
  
  
  METHODS
  We interrogated Korean health claim database data from 2009 to 2013. We enrolled all patients with IBD, and age- and sex-matched control subjects, and evaluated the risks of ISDs, including psoriasis, rosacea, and atopic dermatitis, and the risks of autoimmune skin diseases, including vitiligo and alopecia areata. We used multivariable logistic regression to this end.
  
  
  RESULTS
  ISDs including rosacea, psoriasis, and atopic dermatitis were significantly associated with IBD, whereas the associations between IBD and autoimmune skin diseases including vitiligo and alopecia areata were less marked or nonexistent. Ulcerative colitis and Crohn's disease were both associated with ISDs.
  
  
  CONCLUSIONS
  We were unable to distinguish phenotypes and severities of skin diseases.
  
  
  CONCLUSIONS
  IBD was significantly associated with ISDs, but less so or not at all with autoimmune skin diseases.
authors: Department of Dermatology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
authors: Miri
authors: M
authors: Kim
authors: Veterans Health Service Medical Center, Seoul, Korea.
authors: Kwang Hyun
authors: KH
authors: Choi
authors: Department of Dermatology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
authors: Se Won
authors: SW
authors: Hwang
authors: Department of Dermatology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
authors: Young Bok
authors: YB
authors: Lee
authors: Department of Dermatology, College of Medicine, The Catholic University of Korea, Seoul, Korea. Electronic address: hjpark@catholic.ac.kr.
authors: Hyun Jeong
authors: HJ
authors: Park
authors: Department of Dermatology, College of Medicine, The Catholic University of Korea, Seoul, Korea. Electronic address: jminbae@gmail.com.
authors: Jung Min
authors: JM
authors: Bae
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000506:Alopecia Areata / Q000453:epidemiology; D016022:Case-Control Studies; D002648:Child; D003093:Colitis, Ulcerative / Q000453:epidemiology*; D003424:Crohn Disease / Q000453:epidemiology*; D003430:Cross-Sectional Studies; D003876:Dermatitis, Atopic / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000453:epidemiology; D056910:Republic of Korea / Q000453:epidemiology; D012393:Rosacea / Q000453:epidemiology; D012737:Sex Factors; D012871:Skin Diseases / Q000453:epidemiology*; D014820:Vitiligo / Q000453:epidemiology; D055815:Young Adult
keywords: atopic dermatitis; epidemiology; inflammatory bowel disease; psoriasis; rosacea