title: The Influence of Neoadjuvant Chemotherapy with Docetaxel, Nedaplatin and 5-Fluorouracil After Esophagectomy.
abstract: Neoadjuvant chemotherapy (NAC) with docetaxel, nedaplatin and 5-fluorouracil (5-FU) in esophageal cancer may adversely affect the postoperative clinical course following esophagectomy.
  
  
  
  We investigated the perioperative white blood cell count (WBC), C-reactive protein (CRP), serum albumin, body temperature (BT), heart rate (HR), respiratory rate (RR), water balance, partial pressure of oxygen in arterial blood (PaO2)/fraction of inspired oxygen (FiO2) ratio, postoperative complications and systemic inflammatory response syndrome (SIRS) in patients who underwent NAC or surgery alone (SA group).
  
  
  
  In the NAC group, the preoperative WBC (p=0.015) and postoperative day (POD) 3 BT (p=0.049), as well as RR (p=0.037) were lower, whereas the POD 2 PaO2/FiO2ratio was higher (p=0.047), compared to the SA group. No differences in the incidence of postoperative complications and SIRS were observed between the groups.
  
  
  
  NAC using docetaxel, nedaplatin and 5-fluorouracil was tolerated and feasible in esophageal cancer.
authors: Department of Surgery, Tokyo Women's Medical University Medical Center East, Tokyo, Japan sasaka225@yahoo.co.jp.
authors: Shinichi
authors: S
authors: Asaka
authors: Department of Surgery, Tokyo Women's Medical University Medical Center East, Tokyo, Japan.
authors: Takeshi
authors: T
authors: Shimakawa
authors: Department of Surgery, Tokyo Women's Medical University Medical Center East, Tokyo, Japan.
authors: Kentaro
authors: K
authors: Yamaguchi
authors: Department of Surgery, Tokyo Women's Medical University Medical Center East, Tokyo, Japan.
authors: Minoru
authors: M
authors: Murayama
authors: Department of Surgery, Tokyo Women's Medical University Medical Center East, Tokyo, Japan.
authors: Asako
authors: A
authors: Shimazaki
authors: Department of Surgery, Tokyo Women's Medical University Medical Center East, Tokyo, Japan.
authors: Takao
authors: T
authors: Katsube
authors: Department of Surgery, Tokyo Women's Medical University Medical Center East, Tokyo, Japan.
authors: Yoshihiko
authors: Y
authors: Naritaka
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D000077143:Docetaxel; D004938:Esophageal Neoplasms / Q000188:drug therapy* / Q000601:surgery*; D016629:Esophagectomy; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008297:Male; D009944:Organoplatinum Compounds / Q000008:administration & dosage; D012189:Retrospective Studies; D018746:Systemic Inflammatory Response Syndrome; D043823:Taxoids / Q000008:administration & dosage
chemical_list: D009944:Organoplatinum Compounds; D043823:Taxoids; D000077143:Docetaxel; C053989:nedaplatin; D005472:Fluorouracil
keywords: Neoadjuvant chemotherapy; esophageal cancer; postoperative complications