title: Four new C10-polyacetylene glycosides from the rhizomes of Atractylodes lancea.
abstract: An ongoing phytochemical investigation of the rhizomes of Atractylodes lancea resulted in the isolation of four new C10-type polyacetylene glycosides (1-4). Their structures were elucidated on the basis of extensive spectroscopic data (UV, IR, 1D and 2D NMR, and HRESIMS). The absolute configurations of compounds 2-4 were determined by comparing the specific rotations of their aglycones. Notably, compounds 2 and 3 exhibited significant hepatoprotective activities against APAP-induced HepG2 cell injury at a concentration of 10 μM. Compounds 2 and 3 showed weak anti-inflammatory effects on LPS-induced NO production in microglia BV2 cells at a concentration of 10 μM.
authors: a State Key Laboratory of Bioactive Substance and Function of Natural Medicines , Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences , Beijing 100050 , China.
authors: Kuo
authors: K
authors: Xu
authors: a State Key Laboratory of Bioactive Substance and Function of Natural Medicines , Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences , Beijing 100050 , China.
authors: Zi-Ming
authors: ZM
authors: Feng
authors: a State Key Laboratory of Bioactive Substance and Function of Natural Medicines , Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences , Beijing 100050 , China.
authors: Ya-Nan
authors: YN
authors: Yang
authors: a State Key Laboratory of Bioactive Substance and Function of Natural Medicines , Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences , Beijing 100050 , China.
authors: Jian-Shuang
authors: JS
authors: Jiang
authors: a State Key Laboratory of Bioactive Substance and Function of Natural Medicines , Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences , Beijing 100050 , China.
authors: Pei-Cheng
authors: PC
authors: Zhang
mesh_terms: D000818:Animals; D031174:Atractylodes / Q000737:chemistry*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification*; D056945:Hep G2 Cells; D006801:Humans; D008070:Lipopolysaccharides / Q000494:pharmacology; D051379:Mice; D017628:Microglia / Q000187:drug effects; D015394:Molecular Structure; D009569:Nitric Oxide / Q000096:biosynthesis; D019906:Nuclear Magnetic Resonance, Biomolecular; D053279:Polyynes / Q000302:isolation & purification* / Q000494:pharmacology; D027343:Rhizome / Q000737:chemistry*
chemical_list: D006027:Glycosides; D008070:Lipopolysaccharides; D053279:Polyynes; D009569:Nitric Oxide
keywords: Atractylodes lancea; anti-inflammatory effect; hepatoprotective activity; polyacetylene glycoside