title: Root coverage using porcine collagen matrix with fibroblast growth factor-2: a pilot study in dogs.
abstract: The aim of this study was to evaluate the effect of fibroblast growth factor-2 (FGF-2) in combination with porcine collagen matrix (CM) for coverage of gingival recession defects in dogs.
  
  
  
  In five male mongrel dogs, labial gingival recession defects were surgically created in the lower-third incisors bilaterally. The defects were randomly assigned to the CM/FGF-2 group (experimental) or the CM-only group (control). Standardized clinical photographs and silicone impressions were taken at 4 and 16 weeks of healing to calculate the remaining recession area. The dogs were euthanized after 16 weeks for histometric analysis.
  
  
  
  At 4 weeks, the recession area of the CM/FGF-2 group was significantly smaller than that of the CM-only group (2.55 ± 0.66 and 4.92 ± 1.05 mm2, respectively, p = 0.023), However, no significant difference was observed at 16 weeks. Histometrically, the amount of newly formed cementum was larger in the CM/FGF-2 group than in the CM-only group at 16 weeks (1.55 ± 0.44 and 0.88 ± 0.51 mm, respectively, p = 0.024).
  
  
  
  The combination of CM/FGF-2 may enhance the early wound healing and may promote cementum formation to a higher extent compared to the use of CM alone.
authors: Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, Seoul, Korea.
authors: Jae Kook
authors: JK
authors: Cha
authors: Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, Seoul, Korea.
authors: Yoo-Kyung
authors: YK
authors: Sun
authors: Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, Seoul, Korea.
authors: Jung-Seok
authors: 0000-0003-1276-5978
authors: JS
authors: Lee
authors: Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, Seoul, Korea.
authors: Seong-Ho
authors: SH
authors: Choi
authors: Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, Seoul, Korea.
authors: Ui-Won
authors: 0000-0001-6371-4172
authors: UW
authors: Jung
mesh_terms: D000818:Animals; D003094:Collagen / Q000627:therapeutic use*; D004285:Dogs; D016222:Fibroblast Growth Factor 2 / Q000627:therapeutic use*; D005889:Gingival Recession / Q000628:therapy*; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D008297:Male; D010865:Pilot Projects; D013552:Swine; D014092:Tooth Root
chemical_list: D016222:Fibroblast Growth Factor 2; D003094:Collagen
keywords: collagen matrix; fibroblast growth factor; periodontal regeneration; root coverage