title: Significant pain relief with loading dose zoledronic acid in bone metastases is only seen in patients with elevated initial serum C telopeptide (CTX).
abstract: In symptomatic bone metastases with significant pain, refractory to standard analgesics and radiotherapy, loading dose zoledronic acid (ZA) represents a simple and nontoxic treatment to obtain significant pain relief in a very short time. Its analgesic effect is limited to patients with massive osteoclast activation with high initial serum C-telopeptide (CTX). The pain reduction is proportionally correlated with the reduction of CTX.
authors: Department of Medical Oncology.
authors: J
authors: J
authors: Dekoninck
authors: Department of Medical Oncology.
authors: F
authors: F
authors: Geurs
authors: Laboratory, Regional Hospital Sint Maria, Halle, Belgium.
authors: R
authors: R
authors: De Loecker
authors: Laboratory, Regional Hospital Sint Maria, Halle, Belgium.
authors: Y
authors: Y
authors: Deprest
keywords: CTX levels; VAS score; bisphosphonates; bone resorption