title: Plant-Derived Agents for Counteracting Cisplatin-Induced Nephrotoxicity.
abstract: Cisplatin (CSP) is a chemotherapeutic agent commonly used to treat a variety of malignancies. The major setback with CSP treatment is that its clinical efficacy is compromised by its induction of organ toxicity, particular to the kidneys and ears. Despite the significant strides that have been made in understanding the mechanisms underlying CSP-induced renal toxicity, advances in developing renoprotective strategies are still lacking. In addition, the renoprotective approaches described in the literature reveal partial amelioration of CSP-induced renal toxicity, stressing the need to develop potent combinatorial/synergistic agents for the mitigation of renal toxicity. However, the ideal renoprotective adjuvant should not interfere with the anticancer efficacy of CSP. In this review, we have discussed the progress made in utilizing plant-derived agents (phytochemicals) to combat CSP-induced nephrotoxicity in preclinical studies. Furthermore, we have also presented strategies to utilize phytochemicals as prototypes for the development of novel renoprotective agents for counteracting chemotherapy-induced renal damage.
authors: Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain 17666, UAE.
authors: Shreesh
authors: 0000-0001-7801-2966
authors: S
authors: Ojha
authors: Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain 17666, UAE.
authors: Balaji
authors: B
authors: Venkataraman
authors: Department of Pharmacology and Therapeutics, Beirut Arab University, Beirut, Lebanon.
authors: Amani
authors: A
authors: Kurdi
authors: Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain 17666, UAE.
authors: Eglal
authors: E
authors: Mahgoub
authors: Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain 17666, UAE.
authors: Bassem
authors: B
authors: Sadek
authors: Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain 17666, UAE.
authors: Mohanraj
authors: 0000-0003-2660-2184
authors: M
authors: Rajesh
mesh_terms: D000818:Animals; D002945:Cisplatin / Q000009:adverse effects*; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced* / Q000188:drug therapy*; D064209:Phytochemicals / Q000494:pharmacology / Q000627:therapeutic use*; D008517:Phytotherapy
chemical_list: D064209:Phytochemicals; D002945:Cisplatin