title: Genome-wide association study: new genetic insights into HBV/HCV-related hepatocellular carcinoma genomes.
abstract: Hepatocellular carcinoma (HCC) is the third common cause of cancer-related death with highest prevalence in developing countries, such as Southeast China and Saharan African. The major pathogenic factors can be categorized into environmental effects and genetic variations, and it is mostly caused by hepatitis B or C virus (HBV and HCV). The geographic prevalence of chronic hepatitis B and C (CHB and CHC) varies, with HBV heavily-infected in developing countries and HCV prevalent in developed countries. The infection of either hepatitis virus B or C causes damage to the liver cells through cellular immune attack by the mechanism of inflammation. However, how liver cell injury progresses to HCC development is still poorly understood. Along with the maturation of genome-wide association study (GWAS) technology, the specific genetic mutations responsible for the progression from CHB or CHC to HCC have been identified. Moreover, the findings of similar studies for these variants are different from each other due to diverse populations. More functional experiments are warranted to confirm the precise roles of these genetic mutations in the correlations between HBV/HCV and HCC for the future clinical application.
authors: a Department of Gastroenterology , Fudan University Affiliated Zhongshan Hospital , Shanghai , China.
authors: Hairong
authors: H
authors: Zhu
authors: b Shanghai Institute of Liver Disease, Fudan University Affiliated Zhongshan Hospital , Shanghai , China.|c Department of Medical Microbiology, Key Laboratory of Molecular Virology , Fudan University Shanghai Medical College , Shanghai , China.
authors: Jian
authors: J
authors: Wu
authors: a Department of Gastroenterology , Fudan University Affiliated Zhongshan Hospital , Shanghai , China.|b Shanghai Institute of Liver Disease, Fudan University Affiliated Zhongshan Hospital , Shanghai , China.
authors: Xizhong
authors: X
authors: Shen
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000473:pathology; D002681:China; D055106:Genome-Wide Association Study; D005838:Genotype; D006680:HLA Antigens / Q000235:genetics; D016174:Hepacivirus; D006515:Hepatitis B virus; D019694:Hepatitis B, Chronic / Q000150:complications*; D019698:Hepatitis C, Chronic / Q000150:complications*; D015395:Histocompatibility Antigens Class I / Q000235:genetics; D006801:Humans; D016547:Kinesins / Q000235:genetics; D008113:Liver Neoplasms / Q000235:genetics* / Q000473:pathology; D009154:Mutation; D020641:Polymorphism, Single Nucleotide; D050797:STAT4 Transcription Factor / Q000235:genetics
chemical_list: D006680:HLA Antigens; D015395:Histocompatibility Antigens Class I; C091053:KIF1B protein, human; C099187:MHC class I-related chain A; D050797:STAT4 Transcription Factor; C494090:STAT4 protein, human; D016547:Kinesins
keywords: Gene mutation; Single nucleotide polymorphism; genome-wide association study; hepatocellular carcinoma