title: Activating ATR, the devil's in the dETAA1l.
abstract: Two studies now show that Ewing's tumour-associated antigen 1 (ETAA1) is recruited to sites of DNA replication stress through its interaction with replication protein A, where it stimulates the ATR kinase to promote efficient genome duplication. These findings provide exciting insight into the already very complex regulatory mechanism of the ATR activation cascade.
authors: Department of Oncology, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, OX3 9DS, UK.
authors: Wojciech
authors: W
authors: Niedzwiedz
mesh_terms: D000818:Animals; D000954:Antigens, Surface / Q000378:metabolism*; D064007:Ataxia Telangiectasia Mutated Proteins / Q000378:metabolism*; D018797:Cell Cycle Proteins / Q000235:genetics / Q000378:metabolism*; D004249:DNA Damage / Q000235:genetics*; D004261:DNA Replication / Q000502:physiology*; D006801:Humans; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism
chemical_list: D000954:Antigens, Surface; D018797:Cell Cycle Proteins; C508506:ETAA1 protein, human; D064007:Ataxia Telangiectasia Mutated Proteins; D017346:Protein Serine-Threonine Kinases