title: Tamoxifen Suppresses the Growth of Malignant Pleural Mesothelioma Cells.
abstract: Malignant pleural mesothelioma (MPM) is a rare but highly aggressive malignancy most often associated with exposure to asbestos. Recent evidence points to oestrogen receptor (ER)-β having a tumour-suppressor role in MPM progression, and this raises the question of whether selective modulators of ERs could play a role in augmenting MPM therapy.
  
  
  
  We investigated the action of tamoxifen in inhibiting the growth and modulating the cisplatin sensitivity of four MPM cell lines.
  
  
  
  Tamoxifen inhibited the growth of MPM cells and also modulated their sensitivity to cisplatin. The MPM cell lines expressed ERβ, but the actions of tamoxifen were not blocked by antagonism of nuclear ERs. Tamoxifen treatment repressed the expression of cyclins by MPM cells, resulting in cell-cycle arrest and caspase-3-coupled apoptosis signaling.
  
  
  
  The ER-independent actions of tamoxifen on MPM cell proliferation and cell-cycle progression may have clinical benefits for a subset of patients with MPM.
authors: Department of Molecular Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland.
authors: Cormac J
authors: CJ
authors: Jennings
authors: Department of Molecular Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland.
authors: Najihah
authors: N
authors: Zainal
authors: Department of Molecular Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland.
authors: Izyan M M
authors: IM
authors: Dahlan
authors: Department of Histopathology, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland.
authors: Elaine W
authors: EW
authors: Kay
authors: Department of Molecular Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland.
authors: Brian J
authors: BJ
authors: Harvey
authors: Department of Molecular Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland warren.thomas@perdanauniversity.edu.my.|Perdana University - Royal College of Surgeons in Ireland School of Medicine, Selangor, Malaysia.
authors: Warren
authors: W
authors: Thomas
mesh_terms: D018931:Antineoplastic Agents, Hormonal / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D002945:Cisplatin / Q000008:administration & dosage; D018844:Cyclin-Dependent Kinases / Q000037:antagonists & inhibitors; D006801:Humans; D008654:Mesothelioma / Q000473:pathology*; D010997:Pleural Neoplasms / Q000473:pathology*; D013629:Tamoxifen / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D018931:Antineoplastic Agents, Hormonal; D013629:Tamoxifen; D018844:Cyclin-Dependent Kinases; D002945:Cisplatin
keywords: Mesothelioma; cisplatin; oestrogen receptor; tamoxifen