title: Clinical and Oncological Outcomes of Laparoscopic Versus Open Surgery for Advanced Rectal Cancer.
abstract: To compare the clinical and oncological outcomes of laparoscopic and open approaches in patients with advanced rectal cancer.
  
  
  
  In this study, 78 patients who underwent surgery for advanced middle and lower rectal cancer (pStage II - III) were divided into two groups according to type of surgical approach: laparoscopic surgery (LS group; n=40) and open surgery (OS group: n=38). The clinical outcomes and oncological outcomes were compared between the two groups.
  
  
  
  The operation time was comparable, whereas operative blood loss and complication rates were significantly less in the LS group compared to the OS group. Cancer-specific survival (CSS) and local recurrence-free survival (LRFS) were similar in the two groups. Disease-free survival (DFS) was better in the LS group than in the OS group.
  
  
  
  LS for advanced rectal cancer was safe and not inferior to OS in clinical and oncological outcomes.
authors: Department of Surgery, National Hospital Organization Nagasaki Medical Center, Nagasaki, Japan tnonaka@nagasaki-u.ac.jp.
authors: Takashi
authors: T
authors: Nonaka
authors: Department of Surgery, National Hospital Organization Nagasaki Medical Center, Nagasaki, Japan.
authors: Akiko
authors: A
authors: Fukuda
authors: Department of Surgery, National Hospital Organization Nagasaki Medical Center, Nagasaki, Japan.
authors: Kyoichiro
authors: K
authors: Maekawa
authors: Department of Surgery, National Hospital Organization Nagasaki Medical Center, Nagasaki, Japan.
authors: Shigeki
authors: S
authors: Nagayoshi
authors: Department of Surgery, National Hospital Organization Nagasaki Medical Center, Nagasaki, Japan.
authors: Takayuki
authors: T
authors: Tokunaga
authors: Department of Surgery, National Hospital Organization Nagasaki Medical Center, Nagasaki, Japan.
authors: Mitsuhisa
authors: M
authors: Takatsuki
authors: Department of Surgery, National Hospital Organization Nagasaki Medical Center, Nagasaki, Japan.
authors: Tomoo
authors: T
authors: Kitajima
authors: Department of Surgery, National Hospital Organization Nagasaki Medical Center, Nagasaki, Japan.
authors: Ken
authors: K
authors: Taniguchi
authors: Department of Surgery, National Hospital Organization Nagasaki Medical Center, Nagasaki, Japan.
authors: Hikaru
authors: H
authors: Fujioka
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D010535:Laparoscopy / Q000592:standards*; D007813:Laparotomy / Q000592:standards*; D008297:Male; D012004:Rectal Neoplasms / Q000601:surgery*; D016896:Treatment Outcome
keywords: Laparoscopic surgery; advanced stage; rectal cancer; total mesorectal excision