title: Trypanocidal Activity of 2,5-Diphenyloxazoles Isolated from the Roots of Oxytropis lanata.
abstract: Eleven 2,5-diphenyloxazole derivatives (1-11), together with six known isoflavonoid derivatives, were isolated from the roots of Oxytropis lanata. The 2,5-diphenyloxazole (1) obtained proved to be identical to a standard sample used as a scintillator and liquid laser dye. The other oxazole derivatives isolated were found to have one to four hydroxy and/or O-methyl groups in their phenyl rings. Seven of the oxazole derivatives obtained are new (3-9). The inhibitory activity of the isolated compounds was evaluated against Trypanosoma congolense, the causative agent of African trypanosomosis in animals. Oxazoles with di- and trihydroxy groups showed trypanocidal activity, and 2-(2',3'-dihydroxyphenyl)-5-(2″-hydroxyphenyl)oxazole (4) exhibited the most potent inhibitory activity (IC501.0 μM).
authors: Department of Pharmacognosy, Tohoku Medical and Pharmaceutical University , 4-1 Komatsushima 4-chome, Aoba-ku, Sendai 981-8558, Japan.
authors: Orkhon
authors: O
authors: Banzragchgarav
authors: Department of Pharmacognosy, Tohoku Medical and Pharmaceutical University , 4-1 Komatsushima 4-chome, Aoba-ku, Sendai 981-8558, Japan.
authors: Toshihiro
authors: T
authors: Murata
authors: Natural Product Chemistry Laboratory, Institute of Chemistry and Chemical Technology, Mongolian Academy of Sciences , 13330 Peace Avenue, The 4th Building of MAS, Ulaanbaatar, Mongolia.
authors: Gendaram
authors: G
authors: Odontuya
authors: School of Engineering and Applied Sciences, National University of Mongolia , POB-617, Ulaanbaatar-46A, Mongolia.
authors: Buyanmandakh
authors: B
authors: Buyankhishig
authors: Keisuke
authors: K
authors: Suganuma
authors: School of Engineering and Applied Sciences, National University of Mongolia , POB-617, Ulaanbaatar-46A, Mongolia.
authors: Bekh-Ochir
authors: BO
authors: Davaapurev
authors: Obihiro University of Agriculture and Veterinary Medicine , Inada, Obihiro, Hokkaido 080-8555, Japan.
authors: Noboru
authors: N
authors: Inoue
authors: School of Engineering and Applied Sciences, National University of Mongolia , POB-617, Ulaanbaatar-46A, Mongolia.
authors: Javzan
authors: J
authors: Batkhuu
authors: Department of Pharmacognosy, Tohoku Medical and Pharmaceutical University , 4-1 Komatsushima 4-chome, Aoba-ku, Sendai 981-8558, Japan.
authors: Kenroh
authors: K
authors: Sasaki
mesh_terms: D000818:Animals; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D008986:Mongolia; D019906:Nuclear Magnetic Resonance, Biomolecular; D010080:Oxazoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D033021:Oxytropis / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry*; D014344:Trypanocidal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D014348:Trypanosoma congolense / Q000187:drug effects
chemical_list: C000620037:2-(2',3'-dihydroxyphenyl)-5-(2'-hydroxyphenyl)oxazole; D010080:Oxazoles; D014344:Trypanocidal Agents; C009012:2,5-diphenyloxazole