title: Resolving the Genomic Localization of the Kollerin Cohesin-Loader Complex.
abstract: The kollerin complex, consisting of Scc2/Scc4 in yeast and Nipbl/Mau2 in vertebrates, is crucial for the chromatin-association of the cohesin complex and therefore for the critical functions of cohesin in cell division, transcriptional regulation and chromatin organisation. Despite the recent efforts to determine the genomic localization of the kollerin complex in different cell lines, major questions still remain unresolved, for instance where cohesin is actually loaded onto chromatin. Further, Nipbl seems to have also additional roles, for instance as transcription factor.This chapter summarizes our current knowledge on kollerin function and the recent studies on the genomic localization of Scc2, highlighting and critically discussing controversial data.
authors: Department of Cell Biology, Erasmus MC, Faculty Building, Room Ee1020, Wytemaweg 80, 3015 CN, Rotterdam, The Netherlands. k.wendt@erasmusmc.nl.
authors: Kerstin S
authors: KS
authors: Wendt
mesh_terms: D000251:Adenosine Triphosphatases / Q000235:genetics; D000818:Animals; D018797:Cell Cycle Proteins / Q000235:genetics; D002467:Cell Nucleus / Q000235:genetics / Q000648:ultrastructure; D002843:Chromatin / Q000235:genetics* / Q000648:ultrastructure; D002868:Chromosomal Proteins, Non-Histone / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics; D023281:Genomics; D006801:Humans; D051379:Mice; D008967:Molecular Biology / Q000379:methods*; D046912:Multiprotein Complexes / Q000235:genetics; D011506:Proteins / Q000235:genetics*; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000648:ultrastructure; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics*; D014157:Transcription Factors / Q000235:genetics; D000097722:Cohesins
chemical_list: D000251:Adenosine Triphosphatases; D018797:Cell Cycle Proteins; D002843:Chromatin; D002868:Chromosomal Proteins, Non-Histone; D004268:DNA-Binding Proteins; D046912:Multiprotein Complexes; D011506:Proteins; D029701:Saccharomyces cerevisiae Proteins; D014157:Transcription Factors; D000097722:Cohesins; C487465:NIPBL protein, human; C410592:SCC2 protein, S cerevisiae; C410593:SCC4 protein, S cerevisiae; C108312:condensin complexes
keywords: Cohesin; Cohesin-loading; Condensin; Genomic localization; Kollerin; Nipbl; Transcription factor