title: Surgical management of inflammatory bowel disease in China: a systematic review of two decades.
abstract: OBJECTIVE
  The past decades have seen increasing incidence and prevalence of inflammatory bowel disease (IBD) in China. This article aimed to summarize the current status and characteristics of surgical management for IBD in China.
  
  
  METHODS
  We searched PubMed, Embase, and Chinese databases from January 1, 1990 to July 1, 2014 for all relevant studies on the surgical treatment IBD in China. Eligible studies with sufficient defined variables were further reviewed for primary and secondary outcome measures.
  
  
  RESULTS
  A total of 74 studies comprising 2,007 subjects with Crohn's disease (CD) and 1,085 subjects with ulcerative colitis (UC) were included. The percentage of CD patients misdiagnosed before surgery, including misdiagnosis as appendicitis or UC, was 50.8%±30.9% (578/1,268). The overall postoperative complication rate was 22.3%±13.0% (267/1,501). For studies of UC, the overall postoperative complication rate was 22.2%±27.9% (176/725). In large research centers (n>50 surgical cases), the rates of emergency operations for CD (P=0.032) and in-hospital mortalities resulting from both CD and UC were much lower than those in smaller research centers (n≤50 surgical cases) (P=0.026 andP<0.001, respectively). Regarding the changes in CD and UC surgery over time, postoperative complications (P=0.045 for CD;P=0.020 for UC) and postoperative in-hospital mortality (P=0.0002 for CD;P=0.0160 for UC) both significantly improved after the year 2010.
  
  
  CONCLUSIONS
  The surgical management of IBD in China has improved over time. However, the rates of misdiagnosis and postoperative complications over the past two decades have remained high. Large research centers were found to have relatively better capacity for surgical management than the smaller ones. Higher quality prospective studies are needed in China.
authors: Department of Gastroenterology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors: Qiao
authors: Q
authors: Yu
authors: Department of Gastroenterology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors: Ren
authors: R
authors: Mao
authors: Department of Colorectal Surgery, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors: Lei
authors: L
authors: Lian
authors: Department of Medicine and Therapeutics, Institute of Digestive Disease, State Key Laboratory of Digestive Diseases, Chinese University of Hong Kong, Hong Kong, China.
authors: Siew Chien
authors: SC
authors: Ng
authors: Department of Gastroenterology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors: Shenghong
authors: S
authors: Zhang
authors: Department of General Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors: Zhihui
authors: Z
authors: Chen
authors: Department of Gastroenterology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors: Yanyan
authors: Y
authors: Zhang
authors: Department of Gastroenterology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors: Yun
authors: Y
authors: Qiu
authors: Department of Gastroenterology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors: Baili
authors: B
authors: Chen
authors: Department of Gastroenterology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors: Yao
authors: Y
authors: He
authors: Department of Gastroenterology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors: Zhirong
authors: Z
authors: Zeng
authors: Department of Gastroenterology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.; IBD Service, Department of Gastroenterology, Sheba Medical Center & Sackler School of Medicine, Tel-Aviv University, Tel Hashomer, Israel.
authors: Shomron
authors: S
authors: Ben-Horin
authors: Department of General Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors: Xinming
authors: X
authors: Song
authors: Department of Gastroenterology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors: Minhu
authors: M
authors: Chen
keywords: China; General surgery; Inflammatory bowel disease; Systematic review