title: Phenotype-genotype correlation in multiple primary lung cancer patients in China.
abstract: Due to recent advances in high-resolution detection technology, multiple primary lung cancer (MPLC) is becoming an increasingly common diagnosis. However, the genotype-phenotype correlations in MPLC patients have not yet been assessed. In this study, we analyzed the clinical and pathological data for 129 consecutive MPLC patients who received curative surgery at the Tongji University Shanghai Pulmonary Hospital, China. We have screened 129 patients in the present study and found mutations in EGFR, BRAF, ROS1 and KRAS genes, as well as the rearrangement of the EML4-ALK gene in 113 patients. The mean patient age was 59.9 (25-78) years old and 41 patients were males (31.8%). Among the total patients, 123 (95.4%) had two primary lesions, 5 (3.9%) had three primary lesions, and 1 (0.8%) had four primary lesions. In 38.8% of the patients, all lesions were located on only one side of the body. Most of the detected mutations (98 patients) were in the EGFR gene. The patients exhibited significant differences in the EGFR mutation, age at diagnosis, and foci location.
authors: Department of Thoracic Surgery, Tongji University Shanghai Pulmonary Hospital, Shanghai 200433, China.
authors: Yang
authors: Y
authors: Yang
authors: Key Laboratory of Oral Biomedical Engineering of Ministry of Education, Hospital and School of Stomatology, Wuhan University, Wuhan 430079, China.
authors: Wei
authors: W
authors: Yin
authors: Department of Thoracic Surgery, Tongji University Shanghai Pulmonary Hospital, Shanghai 200433, China.
authors: Wenxin
authors: W
authors: He
authors: Department of Thoracic Surgery, Tongji University Shanghai Pulmonary Hospital, Shanghai 200433, China.
authors: Chao
authors: C
authors: Jiang
authors: Department of Thoracic Surgery, Tongji University Shanghai Pulmonary Hospital, Shanghai 200433, China.
authors: Xiao
authors: X
authors: Zhou
authors: Department of Thoracic Surgery, Tongji University Shanghai Pulmonary Hospital, Shanghai 200433, China.
authors: Xiao
authors: X
authors: Song
authors: Department of Thoracic Surgery, Tongji University Shanghai Pulmonary Hospital, Shanghai 200433, China.
authors: Junjie
authors: J
authors: Zhu
authors: Department of Thoracic Surgery, Tongji University Shanghai Pulmonary Hospital, Shanghai 200433, China.
authors: Ke
authors: K
authors: Fei
authors: Department of Respiratory, Tongji University Shanghai Pulmonary Hospital, Shanghai 200433, China.
authors: Weijun
authors: W
authors: Cao
authors: Department of Thoracic Surgery, Tongji University Shanghai Pulmonary Hospital, Shanghai 200433, China.
authors: Gening
authors: G
authors: Jiang
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics*; D002681:China; D066246:ErbB Receptors / Q000235:genetics; D005260:Female; D056726:Genetic Association Studies; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009154:Mutation; D009367:Neoplasm Staging; D015514:Oncogene Proteins, Fusion / Q000235:genetics; D011505:Protein-Tyrosine Kinases / Q000235:genetics; D011518:Proto-Oncogene Proteins / Q000235:genetics; D048493:Proto-Oncogene Proteins B-raf / Q000235:genetics; D014057:Tomography, X-Ray Computed; D018631:ras Proteins / Q000235:genetics
chemical_list: C522504:EML4-ALK fusion protein, human; D015514:Oncogene Proteins, Fusion; D011518:Proto-Oncogene Proteins; D066246:ErbB Receptors; D011505:Protein-Tyrosine Kinases; C062333:ROS1 protein, human; C482119:BRAF protein, human; D048493:Proto-Oncogene Proteins B-raf; D018631:ras Proteins