title: Mild and Selective Cobalt-Catalyzed Chemodivergent Transfer Hydrogenation of Nitriles.
abstract: Herein, we describe a selective cobalt-catalyzed chemodivergent transfer hydrogenation of nitriles to synthesize primary, secondary, and tertiary amines. The solvent effect plays a key role for the selectivity control. The general applicability of this procedure was highlighted by the synthesis of more than 70 amine products bearing various functional groups in high chemoselectivity. Moreover, this mild system achieved >2000 TONs (turnover numbers) for the transfer hydrogenation of nitriles.
authors: Center of Basic Molecular Science (CBMS), Department of Chemistry, Tsinghua University, Beijing, 100084, China.|Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University (CCNU), China.
authors: Zhihui
authors: Z
authors: Shao
authors: Center of Basic Molecular Science (CBMS), Department of Chemistry, Tsinghua University, Beijing, 100084, China.
authors: Shaomin
authors: S
authors: Fu
authors: Center of Basic Molecular Science (CBMS), Department of Chemistry, Tsinghua University, Beijing, 100084, China.
authors: Mufeng
authors: M
authors: Wei
authors: Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University (CCNU), China.
authors: Shaolin
authors: S
authors: Zhou
authors: Center of Basic Molecular Science (CBMS), Department of Chemistry, Tsinghua University, Beijing, 100084, China.
authors: Qiang
authors: 0000-0002-8402-029X
authors: Q
authors: Liu
keywords: amines; cobalt; nitriles; reductive amination; transfer hydrogenation