title: Plasticity of gastrointestinal vagal afferent satiety signals.
abstract: The vagal link between the gastrointestinal tract and the central nervous system (CNS) has numerous vital functions for maintaining homeostasis. The regulation of energy balance is one which is attracting more and more attention due to the potential for exploiting peripheral hormonal targets as treatments for conditions such as obesity. While physiologically, this system is well tuned and demonstrated to be effective in the regulation of both local function and promoting/terminating food intake the neural connection represents a susceptible pathway for disruption in various disease states. Numerous studies have revealed that obesity in particularly is associated with an array of modifications in vagal afferent function from changes in expression of signaling molecules to altered activation mechanics. In general, these changes in vagal afferent function in obesity further promote food intake instead of the more desirable reduction in food intake. It is essential to gain a comprehensive understanding of the mechanisms responsible for these detrimental effects before we can establish more effective pharmacotherapies or lifestyle strategies for the treatment of obesity and the maintenance of weight loss.
authors: Centre for Nutrition and Gastrointestinal Disease, Discipline of Medicine, University of Adelaide, Adelaide, SA, Australia.|Nutrition and Metabolism, South Australian Health and Medical Research Institute, Adelaide, SA, Australia.|Department of Gastroenterology and Hepatology, Royal Adelaide Hospital, Adelaide, SA, Australia.
authors: A J
authors: AJ
authors: Page
authors: Centre for Nutrition and Gastrointestinal Disease, Discipline of Medicine, University of Adelaide, Adelaide, SA, Australia.|Nutrition and Metabolism, South Australian Health and Medical Research Institute, Adelaide, SA, Australia.|School of Medicine, University of Queensland, St Lucia, QLD, Australia.
authors: S J
authors: SJ
authors: Kentish
mesh_terms: D000818:Animals; D002766:Cholecystokinin / Q000502:physiology; D004151:Dipeptides / Q000502:physiology; D004435:Eating; D041981:Gastrointestinal Tract / Q000294:innervation / Q000502:physiology* / Q000503:physiopathology; D054439:Ghrelin / Q000502:physiology; D052216:Glucagon-Like Peptide 1 / Q000502:physiology; D006801:Humans; D020738:Leptin / Q000502:physiology; D064307:Microbiota; D009473:Neuronal Plasticity; D009765:Obesity / Q000503:physiopathology; D012527:Satiation / Q000502:physiology*; D015398:Signal Transduction; D014630:Vagus Nerve / Q000502:physiology* / Q000503:physiopathology
chemical_list: D004151:Dipeptides; D054439:Ghrelin; D020738:Leptin; C042696:tyrosyltyrosine; D052216:Glucagon-Like Peptide 1; D002766:Cholecystokinin
keywords: gastrointestinal tract; obesity; vagal afferents