title: Morphological Effect of the New Antifungal Agent ME1111 on Hyphal Growth of Trichophyton mentagrophytes, Determined by Scanning and Transmission Electron Microscopy.
abstract: The effects of ME1111, a novel antifungal agent, on the hyphal morphology and ultrastructure of Trichophyton mentagrophytes were investigated by using scanning and transmission electron microscopy. Structural changes, such as pit formation and/or depression of the cell surface, and degeneration of intracellular organelles and plasmolysis were observed after treatment with ME1111. Our results suggest that the inhibition of energy production by ME1111 affects the integrity and function of cellular membranes, leading to fungal cell death.
authors: Teikyo University Institute of Medical Mycology, Tokyo, Japan ynishiya@main.teikyo-u.ac.jp.
authors: Yayoi
authors: Y
authors: Nishiyama
authors: Meiji Seika Pharma Co., Ltd., Tokyo, Japan.
authors: Sho
authors: S
authors: Takahata
authors: Teikyo University Institute of Medical Mycology, Tokyo, Japan.
authors: Shigeru
authors: S
authors: Abe
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D014249:Trichophyton / Q000187:drug effects* / Q000648:ultrastructure
chemical_list: D000935:Antifungal Agents
keywords: antifungal agents; electron microscopy; mode of action; morphology