title: Multiple arterial phase MRI of arterial hypervascular hepatic lesions: improved arterial phase capture and lesion enhancement.
abstract: To establish if triple-phase arterial imaging improves the detection of arterial phase hyperintense lesions based on arterial phase capture, motion artifact degradation, and lesion enhancement when compared to single-phase imaging.
  
  
  
  Patients at risk for hepatocellular carcinoma were imaged at 3.0T. Seventy-three consecutive patients with a standard single-phase MRI and eighty-five consecutive patients were imaged using extracellular contrast with triple arterial phase MRI using three sequential accelerated acquisitions of 8 s. Arterial phase capture and image quality were qualitatively categorized. Forty single-phase and forty-four triple-phase studies contained arterially enhancing lesions > 1 cm with washout appearance. The contrast-to-noise ratio (CNR) of the lesions was calculated. We compared the differences in means with Student t-tests and those in arterial phase capture with a Chi squared test with Yates correction.
  
  
  
  The triple-phase acquisitions captured the early or late arterial phases more frequently than did the single-phase acquisition (99% vs 86%; P value = 0.006). Triple-phase also provided greater number of patients with early or late arterial phase imaging without motion artifact (92% vs 79%, P-value = 0.05). The lesion analysis revealed increased maximum CNR in the triple-phase imaging (704.4) vs. single-phase imaging (517.2), P-value < 0.001.
  
  
  
  Triple-phase acquisition provides more robust arterial phase imaging for hepatic lesions, with increased lesion CNR, compared to standard single-phase arterial phase imaging.
authors: Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, 505 Parnassus Avenue, M391, CA, 94143-0628, USA.
authors: Nabia S
authors: NS
authors: Ikram
authors: Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, 505 Parnassus Avenue, M391, CA, 94143-0628, USA.|Department of Radiology, San Francisco Veteran Affairs Medical Center, San Francisco, CA, USA.
authors: Judy
authors: J
authors: Yee
authors: Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, 505 Parnassus Avenue, M391, CA, 94143-0628, USA.|Department of Radiology, San Francisco Veteran Affairs Medical Center, San Francisco, CA, USA.
authors: Stefanie
authors: S
authors: Weinstein
authors: Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, 505 Parnassus Avenue, M391, CA, 94143-0628, USA.|Department of Radiology, San Francisco Veteran Affairs Medical Center, San Francisco, CA, USA.
authors: Benjamin M
authors: BM
authors: Yeh
authors: Department of Surgery, University of California San Francisco, San Francisco, CA, USA.
authors: Carlos U
authors: CU
authors: Corvera
authors: Department of Medicine, San Francisco Veteran Affairs Medical Center, San Francisco, CA, USA.
authors: Alexander
authors: A
authors: Monto
authors: Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, 505 Parnassus Avenue, M391, CA, 94143-0628, USA. thomas.hope@ucsf.edu.|Department of Radiology, San Francisco Veteran Affairs Medical Center, San Francisco, CA, USA. thomas.hope@ucsf.edu.
authors: Thomas A
authors: TA
authors: Hope
mesh_terms: D000368:Aged; D016477:Artifacts; D006528:Carcinoma, Hepatocellular / Q000098:blood supply* / Q000000981:diagnostic imaging*; D003287:Contrast Media; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D008113:Liver Neoplasms / Q000098:blood supply* / Q000000981:diagnostic imaging*; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009942:Organometallic Compounds; D012189:Retrospective Studies
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; C090600:gadobutrol; C064925:gadodiamide; D019786:Gadolinium DTPA
keywords: Arterial phase imaging; Hepatocellular carcinoma; Liver MRI; Respiratory motion