title: IN.PACT™ Admiral™ drug-coated balloon: Durable, consistent and safe treatment for femoropopliteal peripheral artery disease.
abstract: Endovascular management of peripheral artery disease was until recently limited to percutaneous balloon angioplasty, atherectomy, stent grafts, and bare-metal stents. These therapies have been valuable, but plagued by high restenosis and revascularization rates. Important progress has been made with the introduction of combination devices, including drug-eluting stents and drug-coated balloons (DCB), designed to combat restenosis by locally delivering anti-proliferative drugs. In particular, promising clinical performance has been seen with the Medtronic IN.PACT™ Admiral™ DCB, with durable, consistent and safe results. Rigorous, randomized controlled trials have directly compared this and other drug-delivering devices to their non-drug-coated counterparts with data available through two years. Additionally, trials are ongoing to assess use of drug-coated technologies in combination with traditional therapies in hope of synergistic effects. This review gathers data from currently published clinical trials with the IN.PACT Admiral DCB for the treatment of femoropopliteal peripheral artery disease and explores the possible impact on continuing clinical practice.
authors: Medtronic Vascular, 3850 Brickway Blvd., Santa Rosa, CA 95403, USA. Electronic address: susan.peterson@medtronic.com.
authors: Susan
authors: S
authors: Peterson
authors: Medtronic Vascular, 3850 Brickway Blvd., Santa Rosa, CA 95403, USA.
authors: Melissa
authors: M
authors: Hasenbank
authors: Medtronic Vascular, 3850 Brickway Blvd., Santa Rosa, CA 95403, USA.
authors: Claudio
authors: C
authors: Silvestro
authors: Medtronic Vascular, 3850 Brickway Blvd., Santa Rosa, CA 95403, USA.
authors: Shashank
authors: S
authors: Raina
mesh_terms: D000800:Angioplasty, Balloon; D000818:Animals; D002317:Cardiovascular Agents / Q000008:administration & dosage* / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D020099:Coated Materials, Biocompatible; D005263:Femoral Artery / Q000601:surgery; D006801:Humans; D058729:Peripheral Arterial Disease / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D011150:Popliteal Artery / Q000601:surgery; D016896:Treatment Outcome; D062666:Vascular Access Devices
chemical_list: D002317:Cardiovascular Agents; D020099:Coated Materials, Biocompatible
keywords: Anti-proliferative drug; Arterial lesion revascularization; Drug coating; Paclitaxel; Percutaneous transluminal balloon angioplasty; Peripheral stenosis; Peripheral vascular disease