title: Long-Term Disease Course and Pregnancy Outcomes in Women with Inflammatory Bowel Disease: An Indian Cohort Study.
abstract: The literature on interaction between pregnancy and inflammatory bowel disease (IBD) is inconsistent, and there are no reports on this aspect from Asia. This study evaluated the impact both IBD and pregnancy have on each other in a large cohort of Indian patients.
  
  
  
  In total, 514 females with ulcerative colitis (UC) or Crohn's disease (CD) aged between 18 and 45 years attending IBD clinic, at our institute, from July 2004 to July 2013 were screened, and patients with data on pregnancy status were included (n = 406). Pregnancies were categorized as either before, after or coinciding with disease onset. Long-term disease course was ascertained from prospectively maintained records. Pregnancy and fetal outcomes were recorded from antenatal records or individual interviews.
  
  
  
  Of 406 patients (UC: 336, CD: 70), 310 became pregnant (UC: 256, CD: 54), with a total of 597 pregnancies (UC: 524, CD: 73). More UC patients with pregnancies were in long-term remission than non-pregnant patients (56.7 vs. 43.4 %, p = 0.04). Long-term remission was less frequent in UC patients in whom pregnancy coincided with disease onset than patients with pregnancies before and after/pregnancy after the disease onset (41.4 vs. 62.5 %, p = 0.023). Pregnancies after the disease onset were associated with more cesarean sections and adverse fetal outcomes than pregnancies before disease onset in both UC and CD patients.
  
  
  
  Long-term disease course in UC patients was better in pregnant as compared to non-pregnant patients. Among pregnant UC patients, disease course was worst when pregnancy coincided with disease onset. Pregnancy and fetal outcomes were worse in pregnancy after disease onset than pregnancy before disease onset.
authors: Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, Room No 3111, Third Floor, Teaching Block, New Delhi, 110029, India.
authors: Rajesh Kumar
authors: RK
authors: Padhan
authors: Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, Room No 3111, Third Floor, Teaching Block, New Delhi, 110029, India.
authors: Saurabh
authors: S
authors: Kedia
authors: Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, Room No 3111, Third Floor, Teaching Block, New Delhi, 110029, India.
authors: Sushil Kumar
authors: SK
authors: Garg
authors: Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, Room No 3111, Third Floor, Teaching Block, New Delhi, 110029, India.
authors: Sawan
authors: S
authors: Bopanna
authors: Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, Room No 3111, Third Floor, Teaching Block, New Delhi, 110029, India.
authors: V Pratap
authors: VP
authors: Mouli
authors: Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, Room No 3111, Third Floor, Teaching Block, New Delhi, 110029, India.
authors: Rajan
authors: R
authors: Dhingra
authors: Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, Room No 3065, Third Floor, Teaching Block, New Delhi, 110029, India.
authors: Govind
authors: G
authors: Makharia
authors: Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, Room No 3093, Third Floor, Teaching Block, New Delhi, 110029, India. vins_ahuja@hotmail.com.
authors: Vineet
authors: V
authors: Ahuja
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D002585:Cesarean Section / Q000706:statistics & numerical data; D015331:Cohort Studies; D003093:Colitis, Ulcerative / Q000150:complications* / Q000473:pathology; D003424:Crohn Disease / Q000150:complications* / Q000473:pathology; D018450:Disease Progression; D005260:Female; D006801:Humans; D007194:India; D008875:Middle Aged; D011247:Pregnancy; D011248:Pregnancy Complications / Q000473:pathology; D011256:Pregnancy Outcome; D055815:Young Adult
keywords: Cesarean section; Crohn’s disease; Full term delivery; Pregnancy; Ulcerative colitis