title: The cellular and molecular mechanisms of tissue repair and regeneration as revealed by studies inXenopus.
abstract: Survival of any living organism critically depends on its ability to repair and regenerate damaged tissues and/or organs during its lifetime following injury, disease, or aging. Various animal models from invertebrates to vertebrates have been used to investigate the molecular and cellular mechanisms of wound healing and tissue regeneration. It is hoped that such studies will form the framework for identifying novel clinical treatments that will improve the healing and regenerative capacity of humans. Amongst these models,Xenopusstands out as a particularly versatile and powerful system. This review summarizes recent findings using this model, which have provided fundamental knowledge of the mechanisms responsible for efficient and perfect tissue repair and regeneration.
authors: Division of Cell Matrix Biology and Regenerative Medicine School of Biological Sciences Faculty of Biology Medicine and Health University of Manchester Manchester M13 9PT UK.
authors: Jingjing
authors: J
authors: Li
authors: Division of Cell Matrix Biology and Regenerative Medicine School of Biological Sciences Faculty of Biology Medicine and Health University of Manchester Manchester M13 9PT UK.
authors: Siwei
authors: S
authors: Zhang
authors: Division of Cell Matrix Biology and Regenerative Medicine School of Biological Sciences Faculty of Biology Medicine and Health University of Manchester Manchester M13 9PT UK.
authors: Enrique
authors: 0000-0002-1805-8548
authors: E
authors: Amaya
keywords: limb regeneration; scar‐free wound healing; tail regeneration; tissue regeneration