title: Class III β-Tubulin in Colorectal Cancer: Tissue Distribution and Clinical Analysis of Chinese Patients.
abstract: BACKGROUND Class III β-tubulin (βIII-tubulin) has been reported to express at the invasive margin of colorectal cancer. The present study aimed to investigate the clinical implication of βIII-tubulin expression at the invasive margin of colorectal cancer. MATERIAL AND METHODS We recruited 111 patients with surgically resected colorectal carcinoma for bIII-tubulin expression analysis. The cases with bIII-tubulin-positive tumor cells found only in the invasive front tumor area were assigned to the invasive front group, while the remaining cases were all assigned to the non-invasive front group. Clinical analysis of βIII-tubulin and other clinical data was performed. RESULTS The positive staining rates and staining intensity of bIII-tubulin were significantly different between the invasive and non-invasive front groups (p=0.001 and p=0.006), and there was a significant difference in tumor differentiation between the 2 groups (p=0.032). In the non-invasive front group, staining intensity of bIII-tubulin was significantly associated with positive staining rates and lymphatic metastasis (p<0.001 and p=0.048). CONCLUSIONS Our data showed the tissue distribution of bIII-tubulin expression at invasive margin or diffuse distribution. Expression of bIII-tubulin was correlated with tumor differentiation and lymphatic metastasis, suggesting a potential role of bIII-tubulin in tumor differentiation and metastasis. This study may shed light on bIII-tubulin as a novel potential molecular target for a new anti-cancer drug.
authors: Department of Pathology, Beijing Tongren Hospital, Capital Medical University and Beijing Key Laboratory of Head and Neck Molecular Diagnostic Pathology, Beijing, China (mainland).
authors: Xiaoli
authors: X
authors: Zhao
authors: Department of Pathology, Beijing Tongren Hospital, Capital Medical University and Beijing Key Laboratory of Head and Neck Molecular Diagnostic Pathology, Beijing, China (mainland).
authors: Changli
authors: C
authors: Yue
authors: Department of Pathology, Beijing Tongren Hospital, Capital Medical University and Beijing Key Laboratory of Head and Neck Molecular Diagnostic Pathology, Beijing, China (mainland).
authors: Jiamin
authors: J
authors: Chen
authors: Department of Pathology, Beijing Tongren Hospital, Capital Medical University andBeijing Key Laboratory of Head and Neck Molecular Diagnostic Pathology, Beijing, China (mainland).
authors: Cheng
authors: C
authors: Tian
authors: Department of Pathology, Beijing Tongren Hospital, Capital Medical University and Beijing Key Laboratory of Head and Neck Molecular Diagnostic Pathology, Beijing, China (mainland).
authors: Dongmei
authors: D
authors: Yang
authors: Department of Pathology, Beijing Tongren Hospital, Capital Medical University and Beijing Key Laboratory of Head and Neck Molecular Diagnostic Pathology, Beijing, China (mainland).
authors: Li
authors: L
authors: Xing
authors: Department of Pathology, Beijing Tongren Hospital, Capital Medical University and Beijing Key Laboratory of Head and Neck Molecular Diagnostic Pathology, Beijing, China (mainland).
authors: Honggang
authors: H
authors: Liu
authors: Department of Pathology, Beijing Tongren Hospital, Capital Medical University and Beijing Key Laboratory of Head and Neck Molecular Diagnostic Pathology, Beijing, China (mainland).
authors: Yulan
authors: Y
authors: Jin
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D014408:Biomarkers, Tumor / Q000378:metabolism; D002454:Cell Differentiation / Q000502:physiology; D045744:Cell Line, Tumor; D002681:China; D015179:Colorectal Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D014404:Tubulin / Q000235:genetics / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D014404:Tubulin