title: VEGF gene polymorphisms and outcome of epithelial ovarian cancer patients.
abstract: OBJECTIVE
  Since VEGF polymorphisms were associated with variable protein production, we analyzed herein their roles in outcome of epithelial ovarian cancer (EOC) patients.
  
  
  METHODS
  Genotypes of 85 patients with primary EOC were identified in DNA by real-time PCR. Progression-free survival and overall survival were analyzed using Kaplan-Meier method, univariate Cox model and bootstrap resampling study.
  
  
  RESULTS
  At 60 months of follow-up, progression-free survival was shorter in patients with VEGF c.-2578 CC genotype compared with others (52.7 vs 82.2%; p = 0.04). Those patients had 2.15 more chance of presenting disease progression than others (p = 0.04); bootstrap study validated the result (p = 0.03).
  
  
  CONCLUSIONS
  Our data suggest that VEGF c.-2578C>A polymorphism acts as a prognostic factor in EOC.
authors: Faculty of Medicine, Pontifical Catholic University of Campinas, Campinas, São Paulo, Brazil.
authors: Gabriela Ribeiro
authors: GR
authors: Camerin
authors: Department of Internal Medicine, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.
authors: Angelo Borsarelli Carvalho
authors: AB
authors: Brito
authors: Laboratory of Molecular & Investigative Pathology, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.
authors: José
authors: J
authors: Vassallo
authors: Department of Obstetrics & Gynecology, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.
authors: Sophie Françoise Mauricette
authors: SF
authors: Derchain
authors: Department of Internal Medicine, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.
authors: Carmen Silvia Passos
authors: CS
authors: Lima
mesh_terms: D000483:Alleles; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D000077216:Carcinoma, Ovarian Epithelial; D005260:Female; D005500:Follow-Up Studies; D005838:Genotype; D006801:Humans; D053208:Kaplan-Meier Estimate; D015810:Linkage Disequilibrium; D009367:Neoplasm Staging; D009375:Neoplasms, Glandular and Epithelial / Q000188:drug therapy / Q000235:genetics* / Q000401:mortality* / Q000473:pathology; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000401:mortality* / Q000473:pathology; D063868:Patient Outcome Assessment; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics*
chemical_list: D042461:Vascular Endothelial Growth Factor A
keywords: VEGF; epithelial ovarian cancer; genetic polymorphism; prognosis