title: Highlights of the Global HIV-1 CSF Escape Consortium Meeting, 9 June 2016, Bethesda, MD, USA.
abstract: CSF HIV escape is a recently recognised phenomenon that suggests that despite suppressive treatment, HIV RNA may be detected in the CNS compartment in some individuals. In rare cases this is associated with clinical neurological disease, while in most cases, neurological consequences are not apparent. Attempts at characterising the biological substrates of CSF escape and further investigating the neurological consequences need to be made to better understand the implications of this condition for the HIV cure agenda as well as for clinical outcomes. The Global CSF HIV-1 Escape Consortium meeting, convened by the US National Institute of Mental Health, was a first step to gather investigators from diverse sites to discuss opportunities for future collaborative work on this emerging issue. To better understand CSF HIV escape and allow cross-site data reconciliation, it will be useful to reach a consensus set of definitions of the distinct forms of CSF escape, without which concerted cross-site efforts are difficult.
authors: Division of AIDS Research , National Institute of Mental Health, National Institutes of Health , Bethesda , MD , USA.
authors: Jeymohan
authors: J
authors: Joseph
authors: Department of Infectious Diseases , IRCCS San Raffaele Scientific Institute , Milan , Italy.
authors: Paola
authors: P
authors: Cinque
authors: Division of AIDS Research , National Institute of Mental Health, National Institutes of Health , Bethesda , MD , USA.
authors: Deborah
authors: D
authors: Colosi
authors: Department of HIV Medicine , Ruby Hall Clinic , Pune , India.
authors: Ameet
authors: A
authors: Dravid
authors: Department of Infectious Diseases , 'Dr Victor Babes' Hospital for Infectious and Tropical Diseases , Bucharest , Romania.
authors: Luminita
authors: L
authors: Ene
authors: Department of Pharmacology and Experimental Neuroscience , University of Nebraska Medical Center , Omaha , NE , USA.
authors: Howard
authors: H
authors: Fox
authors: Department of Cancer Immunology and Virology , Dana-Farber Cancer Institute , Boston , MA , USA.
authors: Dana
authors: D
authors: Gabuzda
authors: Department of Infectious Diseases , Sahlgrenska Academy , University of Gothenburg , Gothenburg , Sweden.
authors: Magnus
authors: M
authors: Gisslen
authors: Department of Microbiology and Immunology , University of North Carolina at Chapel Hill , Chapel Hill , NC , USA .
authors: Sarah
authors: S
authors: Beth Joseph
authors: Department of Medicine , University of California , San Diego , CA , USA.
authors: Scott
authors: S
authors: Letendre
authors: Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.
authors: Shibani S
authors: SS
authors: Mukerji
authors: Section of Infections of the Nervous System , National Institute of Neurological Diseases and Stroke , National Institutes of Health , Bethesda , MD , USA.
authors: Avindra
authors: A
authors: Nath
authors: Department of Internal Medicine - HIV Unit , Hospital La Paz-IdiPAZ , Madrid , Spain .
authors: Ignacio
authors: I
authors: Perez-Valero
authors: Johns Hopkins University School of Medicine & Bloomberg School of Public Health , Baltimore , MD , USA.
authors: Deborah
authors: D
authors: Persaud
authors: Department of Neurology , University of California , San Francisco , CA , USA.
authors: Richard W
authors: RW
authors: Price
authors: Division of AIDS Research , National Institute of Mental Health, National Institutes of Health , Bethesda , MD , USA.
authors: Vasudev R
authors: VR
authors: Rao
authors: Department of Neurology , Johns Hopkins University , Baltimore , MD , USA.
authors: Ned
authors: N
authors: Sacktor
authors: Department of Microbiology and Immunology , University of North Carolina at Chapel Hill , Chapel Hill , NC , USA .
authors: Ronald
authors: R
authors: Swanstrom
authors: Division of Infectious Diseases , Imperial College London , London , UK.
authors: Alan
authors: A
authors: Winston
authors: Division of Neurology , University of Puerto Rico-Medical Sciences Campus , San Juan , PR , USA.
authors: Valerie
authors: V
authors: Wojna
authors: Department of Infectious Diseases , Alfred Health , Melbourne , Australia.
authors: Edwina
authors: E
authors: Wright
authors: Department of Neurology , Yale University , New Haven , CT , USA.
authors: Serena
authors: S
authors: Spudich