title: How to choose and understand clinical laboratory tests in daily clinical management of hematologic diseases.
abstract: General statements have been published regarding the clinical laboratory tests for thrombosis and hemostasis to be used by hematologists who do not specialize in this field. Screening tests for bleeding are bleeding time, capillary fragility test, platelet count, prothrombin time, activated partial thromboplastin time (APTT), fibrinogen, fibrin/fibrinogen degradation products (FDP), and the cross mixing test conducted by measuring APTT. Screening tests for thrombosis and related factors include measurements of FDP, D-dimer, and thrombin-antithrombin complex. To assess thrombotic factors, we should measure antithrombin (AT), protein C, protein S, antiphospholipid antibody, and heparin induced thrombocytopenia antibody. If a congenital thrombotic factor abnormality is suspected, the clinician should examine activities of AT, protein C, protein S, plasminogen, and fibrinogen. Antigen levels of each parameter are also examined, if warranted. The cross mixing test conducted by measuring APTT is useful for differentiating between deficiencies and inhibitor presence.
authors: Department of Hematology, Uonuma Institute of Community Medicine, Niigata University Medical and Dental Hospital.
authors: Yoshinobu
authors: Y
authors: Seki
mesh_terms: D000554:Ambulatory Care Facilities; D015415:Biomarkers / Q000032:analysis; D006402:Hematologic Diseases / Q000175:diagnosis*; D006403:Hematologic Tests; D006487:Hemostasis; D006801:Humans; D013927:Thrombosis / Q000175:diagnosis
chemical_list: D015415:Biomarkers