title: Oxidative Stress Markers and Their Dynamic Changes in Patients after Acute Ischemic Stroke.
abstract: We have focused on determining the range of oxidative stress biomarkers and their dynamic changes in patients at different time points after the acute ischemic stroke (AIS). 82 patients with AIS were involved in our study and were tested: within 24 h from the onset of the attack (group A); at 7-day follow-up (group B); and at 3-month follow-up (group C). 81 gender and age matched volunteers were used as controls. Stroke patients in group A had significantly higher concentrations of plasma lipid peroxides and urine 8-isoprostanes when compared with controls. Protein carbonyls were not significantly different in any experimental group compared to controls. Antioxidant capacity of plasma was increased only in experimental group C. Activities of superoxide dismutase and catalase were elevated in all three experimental AIS groups compared to controls. Paraoxonase activity was reduced in groups A and B and unchanged in group C when compared to controls. Glutathione peroxide activity was elevated only in group A. Our results suggest that free radical damage is the highest within 24 h after the attack. During the next 3 months oxidative damage to lipids caused by free radicals is reduced due to activated antioxidant system.
authors: Institute of Medical Chemistry, Biochemistry and Clinical Biochemistry, Faculty of Medicine, Comenius University, Bratislava, Slovakia.
authors: Ingrid
authors: 0000-0003-0291-3375
authors: I
authors: Žitňanová
authors: 1st Department of Neurology, Faculty of Medicine, Comenius University, Bratislava, Slovakia.
authors: Pavol
authors: 0000-0001-6388-6273
authors: P
authors: Šiarnik
authors: 1st Department of Neurology, Faculty of Medicine, Comenius University, Bratislava, Slovakia.
authors: Branislav
authors: B
authors: Kollár
authors: Institute of Medical Chemistry, Biochemistry and Clinical Biochemistry, Faculty of Medicine, Comenius University, Bratislava, Slovakia.
authors: Mária
authors: M
authors: Chomová
authors: Institute of Medical Chemistry, Biochemistry and Clinical Biochemistry, Faculty of Medicine, Comenius University, Bratislava, Slovakia.
authors: Petra
authors: P
authors: Pazderová
authors: Institute of Medical Chemistry, Biochemistry and Clinical Biochemistry, Faculty of Medicine, Comenius University, Bratislava, Slovakia.
authors: Lucia
authors: L
authors: Andrezálová
authors: Institute of Medical Chemistry, Biochemistry and Clinical Biochemistry, Faculty of Medicine, Comenius University, Bratislava, Slovakia.
authors: Miriam
authors: M
authors: Ježovičová
authors: Institute of Medical Chemistry, Biochemistry and Clinical Biochemistry, Faculty of Medicine, Comenius University, Bratislava, Slovakia.
authors: Katarína
authors: K
authors: Koňariková
authors: Institute of Medical Chemistry, Biochemistry and Clinical Biochemistry, Faculty of Medicine, Comenius University, Bratislava, Slovakia.
authors: Lucia
authors: L
authors: Laubertová
authors: 2nd Department of Internal Medicine, Faculty of Medicine, Comenius University, Bratislava, Slovakia.
authors: Zuzana
authors: Z
authors: Krivošíková
authors: 2nd Department of Internal Medicine, Faculty of Medicine, Comenius University, Bratislava, Slovakia.
authors: Laura
authors: L
authors: Slezáková
authors: 1st Department of Neurology, Faculty of Medicine, Comenius University, Bratislava, Slovakia.
authors: Peter
authors: P
authors: Turčáni
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000975:Antioxidants / Q000378:metabolism; D043303:Aryldialkylphosphatase / Q000097:blood; D015415:Biomarkers / Q000032:analysis / Q000097:blood; D016022:Case-Control Studies; D002374:Catalase / Q000378:metabolism; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D005979:Glutathione Peroxidase / Q000378:metabolism; D006801:Humans; D008054:Lipid Peroxides / Q000097:blood; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D020521:Stroke / Q000378:metabolism / Q000473:pathology*; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008054:Lipid Peroxides; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D043303:Aryldialkylphosphatase