title: The Role of ABO Blood Group in Cerebral Vasospasm, Associated Intracranial Hemorrhage, and Delayed Cerebral Ischemia in 470 Patients with Subarachnoid Hemorrhage.
abstract: OBJECTIVE
  Rupture of an intracranial aneurysm usually presents with an acute onset and requires multidisciplinary intensive care treatment and the overall death and disability rates are high. The ABO blood type is known to play an important role in hemostasis, thrombosis, and vascular NO response. The aspect of ABO blood type in onset, clinical progress, and outcome after subarachnoid hemorrhage (SAH) is largely unexplored. We conducted this study to elucidate the association of ABO blood type with the occurrence and outcome of aneurysmal SAH.
  
  
  METHODS
  In our retrospective study, 470 patients with aneurysmal SAH treated at our institution were included. We performed a χ2test for comparison between blood types and World Federation of Neurosurgical Societies admission status, cerebral vasospasm, delayed infarction, associated intracerebral hemorrhage and Fisher grade for analysis for their association with SAH.
  
  
  RESULTS
  No significant difference between blood type and the reviewed variables for SAH outcome were identified: World Federation of Neurosurgical Societies admission status (odds ratio, 1.12; 95% confidence interval [CI], 0.7-1.6; P = 0.56); SAH-associated intracerebral hemorrhage (odds ratio, 0.81; 95% CI, 0.5-1.3; P = 0.36); cerebral vasospasm (odds ratio, 1.08; 95% CI, 0.7-1.6; P = 0.71); DCI (odds ratio, 1.23; 95% CI, 0.8-1.8; P = 0.30); Fisher grade (odds ratio, 1.13; 95% CI, 0.7-1.6; P = 0.19).
  
  
  CONCLUSIONS
  Although a possible relationship between the ABO blood group and the clinical course of patients with SAH was hypothesized, our study showed no significant influence of patient's ABO blood type on cerebral vasospasm onset, SAH-associated intracerebral hemorrhage, or delayed infarction.
authors: Department of Neurosurgery, University Hospital, Goethe University, Frankfurt, Germany. Electronic address: daniel.dubinski@kgu.de.
authors: Daniel
authors: D
authors: Dubinski
authors: Department of Neurosurgery, University Hospital, Goethe University, Frankfurt, Germany.
authors: Sae-Yeon
authors: SY
authors: Won
authors: Department of Neurosurgery, University Hospital, Goethe University, Frankfurt, Germany.
authors: Jürgen
authors: J
authors: Konczalla
authors: Department of Neurosurgery, University Hospital, Goethe University, Frankfurt, Germany; Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital, Goethe University, Frankfurt, Germany.
authors: Jan
authors: J
authors: Mersmann
authors: Institute for Transfusion Medicine and Immunohematology, Goethe University, Frankfurt, Germany.
authors: Christof
authors: C
authors: Geisen
authors: Institute of Biostatistics and Mathematical Modelling, Goethe University, Frankfurt, Germany.
authors: Eva
authors: E
authors: Herrmann
authors: Department of Neurosurgery, University Hospital, Goethe University, Frankfurt, Germany.
authors: Volker
authors: V
authors: Seifert
authors: Department of Neurosurgery, University Hospital, Goethe University, Frankfurt, Germany.
authors: Christian
authors: C
authors: Senft
mesh_terms: D000017:ABO Blood-Group System / Q000097:blood*; D000293:Adolescent; D000328:Adult; D000368:Aged; D002545:Brain Ischemia / Q000097:blood* / Q000453:epidemiology / Q000517:prevention & control; D015984:Causality; D002648:Child; D002675:Child, Preschool; D015897:Comorbidity; D018450:Disease Progression; D005260:Female; D005858:Germany / Q000453:epidemiology; D006801:Humans; D002532:Intracranial Aneurysm / Q000097:blood* / Q000453:epidemiology / Q000628:therapy; D020300:Intracranial Hemorrhages / Q000097:blood* / Q000453:epidemiology / Q000517:prevention & control; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000097:blood / Q000453:epidemiology / Q000517:prevention & control; D015995:Prevalence; D012307:Risk Factors; D013345:Subarachnoid Hemorrhage / Q000097:blood* / Q000453:epidemiology / Q000628:therapy*; D020301:Vasospasm, Intracranial / Q000097:blood* / Q000453:epidemiology / Q000517:prevention & control; D055815:Young Adult
chemical_list: D000017:ABO Blood-Group System
keywords: Cerebral vasospasm; Delayed cerebral ischemia; Hemostasis; Nitric oxide; Stroke and blood coagulation