title: The Association between the Lipids Levels in Blood and Risk of Age-Related Macular Degeneration.
abstract: Lipid metabolism may be involved in the pathogenic mechanism of age-related macular degeneration (AMD). However, conflicting results have been reported in the associations of AMD with blood lipids. We performed a meta-analysis including a total of 19 studies to evaluate associations between blood lipids and this disease. The result reported that the high level of high-density lipoprotein cholesterol (HDL-C) obtained with an increment of 1 mmol/L could result in a significantly increase in the AMD risk of approximately 18% (relative risk (RR), 1.18; 95% confidence interval (CI), 1.01 to 1.35;I² = 53.8%;p= 0.007). High levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG) were significantly associated with a decreased risk of AMD (RRs ranging from 0.92 to 0.95; allp< 0.05). The stratified analysis based on AMD subtypes showed that these blood lipids were only significantly associated with the risk of early AMD (allp< 0.05). The association between the blood lipids and AMD risk did not differ substantially based on the other characteristics of the participants. A high HDL-C level was associated with an increased AMD risk, whereas participants with high TC, LDL-C, and TG concentrations may show a decreased risk for this disease. Further well-designed large studies are warranted to confirm the conclusions.
authors: The First Affiliated Hospital, Xi'an Jiaotong University College of Medicine, Xi'an 710061, China. wyf.90.25.wyf@stu.xjtu.edu.cn.|Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an 710004, China. wyf.90.25.wyf@stu.xjtu.edu.cn.|School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an 710049, China. wyf.90.25.wyf@stu.xjtu.edu.cn.
authors: Yafeng
authors: Y
authors: Wang
authors: School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an 710049, China. wangmx601@xjtu.edu.cn.
authors: Mingxu
authors: M
authors: Wang
authors: Department of Public Health, Xi'an Medical University, Xi'an 710021, China. dyzhou@nwpu.edu.cn.
authors: Xiaoqing
authors: X
authors: Zhang
authors: School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an 710049, China. MICHELLE921019@stu.xjtu.edu.cn.
authors: Qianyu
authors: Q
authors: Zhang
authors: School of Humanities, Xi'an Jiaotong University, Xi'an 710049, China. boraisrighthere@sina.com.
authors: Jing
authors: J
authors: Nie
authors: Xi'an Honghui Hospital, Xi'an 710054, China. xgcgfd@126.com.
authors: Ming
authors: M
authors: Zhang
authors: The First Affiliated Hospital, Xi'an Jiaotong University College of Medicine, Xi'an 710061, China. liuxiaoh@mail.xjtu.edu.cn.
authors: Xiaohong
authors: X
authors: Liu
authors: Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an 710004, China. male@mail.xjtu.edu.cn.|School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an 710049, China. male@mail.xjtu.edu.cn.|Key Laboratory of Environment and Genes Related to Diseases (Xi'an Jiaotong University), Ministry of Education of China, Xi'an 710049, China. male@mail.xjtu.edu.cn.
authors: Le
authors: L
authors: Ma
mesh_terms: D000368:Aged; D008076:Cholesterol, HDL / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood*; D005260:Female; D006801:Humans; D008268:Macular Degeneration / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood*
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides
keywords: HDL; age-related macular degeneration; blood lipids levels; meta-analysis