title: Roles of microRNAs in psoriasis: Immunological functions and potential biomarkers.
abstract: MicroRNAs (miRNAs) are small non-coding RNA molecules, which function in RNA silencing and post-transcriptional regulation of gene expression. Psoriasis is an inflammatory skin disease characterized by the dysfunction of keratinocytes, with the immune dysregulation. We reviewed the recent studies on the roles of miRNAs in psoriasis and showed that miRNAs play key roles in psoriasis, including the regulation of hyperproliferation, cytokine and chemokine production in keratinocyte, as well as mediating immune dysfunction in psoriasis. Furthermore, miRNAs, particularly, circulating miRNAs may serve as novel biomarkers for diagnosis, monitoring therapy response and reflecting the disease severity. Thus, targeting specific miRNAs may be used to develop new therapeutic methods for psoriasis.
authors: Guangdong Provincial Hospital of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China.|Department of Immunology, School of medicine, Fudan University, Shanghai, China.
authors: Qing
authors: Q
authors: Liu
authors: Guangdong Provincial Hospital of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China.|Henry Ford Immunology Program, Henry Ford Health System, Detroit, MI, USA.|Department of Dermatology, Henry Ford Health System, Detroit, MI, USA.
authors: Ding-Hong
authors: DH
authors: Wu
authors: Guangdong Provincial Hospital of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China.|Henry Ford Immunology Program, Henry Ford Health System, Detroit, MI, USA.|Department of Dermatology, Henry Ford Health System, Detroit, MI, USA.
authors: Ling
authors: L
authors: Han
authors: Guangdong Provincial Hospital of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China.|Henry Ford Immunology Program, Henry Ford Health System, Detroit, MI, USA.|Department of Dermatology, Henry Ford Health System, Detroit, MI, USA.
authors: Jing-Wen
authors: JW
authors: Deng
authors: Henry Ford Immunology Program, Henry Ford Health System, Detroit, MI, USA.|Department of Dermatology, Henry Ford Health System, Detroit, MI, USA.|Department of Internal Medicine, Henry Ford Health System, Detroit, MI, USA.
authors: Li
authors: L
authors: Zhou
authors: Department of Immunology, School of medicine, Fudan University, Shanghai, China.
authors: Rui
authors: R
authors: He
authors: Guangdong Provincial Hospital of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China.
authors: Chuan-Jian
authors: CJ
authors: Lu
authors: Henry Ford Immunology Program, Henry Ford Health System, Detroit, MI, USA.|Department of Dermatology, Henry Ford Health System, Detroit, MI, USA.|Department of Internal Medicine, Henry Ford Health System, Detroit, MI, USA.
authors: Qing-Sheng
authors: QS
authors: Mi
mesh_terms: D015415:Biomarkers / Q000097:blood; D049109:Cell Proliferation; D006801:Humans; D007111:Immunity, Cellular; D015603:Keratinocytes / Q000502:physiology; D035683:MicroRNAs / Q000097:blood / Q000235:genetics* / Q000276:immunology*; D058990:Molecular Targeted Therapy; D011565:Psoriasis / Q000097:blood / Q000188:drug therapy / Q000235:genetics* / Q000276:immunology*; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers; D035683:MicroRNAs
keywords: biomarkers; immunological mechanisms; miRNA; psoriasis