title: Higher resolution cine imaging with compressed sensing for accelerated clinical left ventricular evaluation.
abstract: To assess the clinical feasibility of a compressed sensing cine magnetic resonance imaging (MRI) sequence of both high temporal and spatial resolution (CS_bSSFP) in comparison to a balanced steady-state free precession cine (bSSFP) sequence for reliable quantification of left ventricular (LV) volumes and mass.
  
  
  
  Segmented MRI cine images were acquired on a 1.5T scanner in 50 patients in the LV short-axis stack orientation using a retrospectively gated conventional bSSFP sequence (generalized autocalibrating partially parallel acquisition [GRAPPA] acceleration factor 2), followed by a prospectively triggered CS_bSSFP sequence with net acceleration factor of 8. Image quality was assessed by published criteria. Comparison of sequences was made in LV volumes and mass, image quality score, quantitative regional myocardial wall motion, and imaging time using Pearson's correlation, Bland-Altman and paired 2-tailed Student's t-test.
  
  
  
  Differences (bSSFP minus CS_bSSFP, mean ± SD) and Pearson's correlations were 14.8 ± 16.3 (P = 0.31) and r = 0.98 (P < 0.0001) for end-diastolic volume (EDV), 8.4 ± 11.3 (P = 0.54) and r = 0.99 (P < 0.0001) for end-systolic volume (ESV), -0.4 ± 2.5 (P = 0.87) and r = 0.97 (P < 0.0001) for EF, and -0.9 ± 11.8 (P = 0.92) and r = 0.97 (P < 0.0001) for LV mass. Bland-Altman analyses [bias and (limits of agreement)] revealed strong agreement in LVEDV [8.7 ml, (-12.1, 29.6)], LVESV [4.3 ml, (-11.9, 20.6)], LVEF [-0.02%, (-5.37, 5.33)], and myocardial mass [-6.1 g, (-14.7, 26.9)]. Image quality was comparable with a similar mean score (P = 0.42), with a good correlation in image quality observed (r = 0.68, P < 0.0001). Quantitative regional myocardial wall motion demonstrated strong correlation between the sequences (r = 0.87, P < 0.0001). Imaging time was significantly shorter for the CS_bSSFP sequence (1.1 ± 0.5 versus 5.6 ± 1.6 min, P < 0.0001).
  
  
  
  The novel high-resolution cine CS_bSSFP accurately and reliably quantitates LV volumes and mass, shortens acquisition times, and is clinically feasible.
  
  
  
  1 Technical Efficacy: Stage 2 J. MAGN. RESON. IMAGING 2017;45:1693-1699.
authors: Richard Slaughter Centre of Excellence in CVMRI, Prince Charles Hospital, Brisbane, Australia.|Menzies Health Institute Queensland and Griffith University, Gold Coast, Australia.
authors: Aaron C W
authors: ACW
authors: Lin
authors: Richard Slaughter Centre of Excellence in CVMRI, Prince Charles Hospital, Brisbane, Australia.|Menzies Health Institute Queensland and Griffith University, Gold Coast, Australia.
authors: Wendy
authors: W
authors: Strugnell
authors: Richard Slaughter Centre of Excellence in CVMRI, Prince Charles Hospital, Brisbane, Australia.
authors: Robyn
authors: R
authors: Riley
authors: Siemens Healthcare Pty Ltd, Sydney, Australia.
authors: Benjamin
authors: B
authors: Schmitt
authors: Siemens Healthcare GmbH, Erlangen, Germany.
authors: Michael
authors: M
authors: Zenge
authors: Siemens Healthcare GmbH, Erlangen, Germany.
authors: Michaela
authors: M
authors: Schmidt
authors: Menzies Health Institute Queensland and Griffith University, Gold Coast, Australia.
authors: Norman R
authors: NR
authors: Morris
authors: Richard Slaughter Centre of Excellence in CVMRI, Prince Charles Hospital, Brisbane, Australia.|University of Queensland, Brisbane, Australia.
authors: Christian
authors: C
authors: Hamilton-Craig
mesh_terms: D000328:Adult; D000368:Aged; D044962:Data Compression / Q000379:methods*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D019028:Magnetic Resonance Imaging, Cine / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012815:Signal Processing, Computer-Assisted; D013318:Stroke Volume; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000473:pathology; D055815:Young Adult
keywords: bSSFP; cardiac magnetic resonance; compressed sensing; left ventricle