title: From the stem of the placental tree: trophoblast stem cells and their progeny.
abstract: Trophoblast stem cells (TSCs) retain the capacity to self-renew indefinitely and harbour the potential to differentiate into all trophoblast subtypes of the placenta. Recent studies have shown how signalling cascades integrate with transcription factor circuits to govern the fine balance between TSC self-renewal and differentiation. In addition, breakthroughs in reprogramming strategies have enabled the generation of TSCs from fibroblasts, opening up exciting new avenues that may allow the isolation of this stem cell type from other species, notably humans. Here, we review these recent advances in light of their importance for understanding placental pathologies and developing personalised medicine approaches for pregnancy complications.
authors: Centre for Trophoblast Research, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK.|Epigenetics Programme, The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK.
authors: Paulina Anna
authors: PA
authors: Latos
authors: Centre for Trophoblast Research, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK myriam.hemberger@babraham.ac.uk.|Epigenetics Programme, The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK.
authors: Myriam
authors: 0000-0003-3332-6958
authors: M
authors: Hemberger
mesh_terms: D000818:Animals; D005260:Female; D005347:Fibroblasts / Q000166:cytology / Q000378:metabolism; D006801:Humans; D010920:Placenta / Q000166:cytology* / Q000378:metabolism; D011247:Pregnancy; D015398:Signal Transduction / Q000502:physiology; D013234:Stem Cells / Q000166:cytology* / Q000378:metabolism; D014327:Trophoblasts / Q000166:cytology* / Q000378:metabolism
keywords: Epigenetics; Placenta; Reprogramming; Stem cells; Transcription factors; Trophoblast