title: Effects of Single Administration of Bupropion on Carboxypeptidase E Activity in Structures of Rat Brain.
abstract: Depression is associated with changes in the levels of some neurotransmitters in various brain structures. Being the key enzyme of peptide processing, carboxypeptidase E regulates their levels in various structures of the nervous system. Single injection of bupropion induced long-lasting changes in carboxypeptidase E activity in all brain structures. The decrease in enzyme activity observed in 12 and 24 h after bupropion injection confirmed the inhibiting effect of the drug on the hypothalamic-pituitary-adrenal axis. Activation of the enzyme in the medulla oblongata, hypothalamus, and hippocampus observed in 72 h after bupropion administration probably leads to enhanced synthesis and secretion of regulatory peptides (reduced during stress and depression) and stimulation of neurogenesis. Changes in enzyme activity can be a mechanism regulating the level of bioactive peptides involved in the pathogenesis of depression.
authors: Department of General Biology and Biochemistry, Penza State University, Penza, Russia. a.d.kruchinina@mail.ru.
authors: A D
authors: AD
authors: Kruchinina
authors: Department of General Biology and Biochemistry, Penza State University, Penza, Russia.
authors: S S
authors: SS
authors: Gamzin
authors: Department of General Biology and Biochemistry, Penza State University, Penza, Russia.
authors: M T
authors: MT
authors: Tengin
mesh_terms: D000818:Animals; D021461:Animals, Outbred Strains; D018687:Antidepressive Agents, Second-Generation / Q000494:pharmacology*; D016642:Bupropion / Q000494:pharmacology*; D043423:Carboxypeptidase H / Q000037:antagonists & inhibitors* / Q000378:metabolism; D004334:Drug Administration Schedule; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects* / Q000502:physiology; D007031:Hypothalamus / Q000187:drug effects / Q000502:physiology; D007274:Injections, Intraperitoneal; D008526:Medulla Oblongata / Q000187:drug effects / Q000502:physiology; D010902:Pituitary Gland / Q000187:drug effects / Q000502:physiology; D010913:Pituitary-Adrenal System / Q000187:drug effects* / Q000502:physiology; D051381:Rats
chemical_list: D018687:Antidepressive Agents, Second-Generation; D016642:Bupropion; D043423:Carboxypeptidase H
keywords: bupropion; carboxypeptidase E; depression; monoamines; regulatory peptides