title: [Advances in the association of ATP-sensitive potassium channels and Parkinson's disease].
abstract: ATP-sensitive potassium channels (KATP), as an inward rectifying potassium channel, are widely distributed in many types of tissues. KATPare activated by the depletion of ATP level and the increase in oxidative stress in cells. The activity of KATPcouples cell metabolism with electrical activity and results in membrane hyperpolarization. KATPare ubiquitously distributed in the brain, including substantia nigra, hippocampus, hypothalamus, cerebral cortex, dorsal nucleus of vagus and glial cells, and participate in neuronal excitability, mitochondria homeostasis and neurotransmitter release. Accumulating lines of evidence suggest that KATPare the major contributing factors in the pathogenesis of Parkinson's disease (PD). This review discussed the association of KATPwith the pathogenic processes of PD by focusing on the roles of KATPon the degeneration of dopaminergic neurons, the functions of mitochondria, the firing pattern of dopaminergic neurons in the substantia nigra, the α-synuclein secretion from striatum, and the microglia activation.
authors: Department of Physiology, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders, Shandong Provincial Collaborative Innovation Center for Neurodegenerative Disorders, Medical College of Qingdao University, Qingdao 266071,China.
authors: Xi-Xun
authors: XX
authors: DU
authors: Department of Physiology, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders, Shandong Provincial Collaborative Innovation Center for Neurodegenerative Disorders, Medical College of Qingdao University, Qingdao 266071,China.
authors: Kang
authors: K
authors: Qin
authors: Department of Physiology, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders, Shandong Provincial Collaborative Innovation Center for Neurodegenerative Disorders, Medical College of Qingdao University, Qingdao 266071,China.
authors: Qian
authors: Q
authors: Jiao
authors: Department of Physiology, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders, Shandong Provincial Collaborative Innovation Center for Neurodegenerative Disorders, Medical College of Qingdao University, Qingdao 266071,China.
authors: Jun-Xia
authors: JX
authors: Xie
authors: Department of Physiology, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders, Shandong Provincial Collaborative Innovation Center for Neurodegenerative Disorders, Medical College of Qingdao University, Qingdao 266071,China. hongjiang@qdu.edu.cn.
authors: Hong
authors: H
authors: Jiang
mesh_terms: D059290:Dopaminergic Neurons; D006801:Humans; D054086:KATP Channels; D008928:Mitochondria; D018384:Oxidative Stress; D010300:Parkinson Disease; D009435:Synaptic Transmission
chemical_list: D054086:KATP Channels