title: The frailty in elderly patients receiving cardiac interventional procedures (FRASER) program: rational and design of a multicenter prospective study.
abstract: BACKGROUND
  Frailty has become a high-priority issue in cardiovascular medicine because of the aging of cardiovascular patients. Simple and reproducible tools to assess frailty in elderly patients are clearly on demand. Their application may help physicians in the selection of invasive and medical treatments and in the timing and modality of the follow-up. The frailty in elderly patients receiving cardiac interventional procedures (FRASER) program is designed with the aim to validate the use of the short physical performance battery (SPPB) as prognostic tools in patients admitted to hospital for acute coronary syndrome (ACS).
  
  
  METHODS
  The FRASER program is a multicenter prospective study involving 4 Italian cardiology units. The FRASER program enrolls only patients aged ≥70 years. The core of the FRASER program includes patients admitted to hospital for ACS. The aims are (1) to describe SPPB distribution before hospital discharge and (2) to investigate the prognostic role of SPPB score. The primary outcome is a composite of 1-year all-cause mortality and hospital readmission for any cause. Ancillary analyses will be focused on different study populations (patients hospitalized for arrhythmias or acute heart failure or symptomatic severe aortic stenosis) and on different tools to assess frailty (multidimensional prognostic index, clinical frailty score, grip strength).
  
  
  CONCLUSIONS
  The FRASER program will fill critical gaps in the knowledge regarding the link between frailty, cardiovascular disease, interventional procedures and outcome and will help physicians in the generation of a more personalized risk assessment and in the identification of potential targets for interventions.
authors: Cardiology Unit, Cardiovascular Institute, Azienda Ospedaliero-Universitaria di Ferrara, Via Aldo Moro, 8, 44124, Cona, FE, Italy. cmpglc@unife.it.|Laboratorio per le Tecnologie delle Terapie Avanzate (LTTA) Center, Ferrara, Italy. cmpglc@unife.it.
authors: Gianluca
authors: G
authors: Campo
authors: Cardiology Unit, Cardiovascular Institute, Azienda Ospedaliero-Universitaria di Ferrara, Via Aldo Moro, 8, 44124, Cona, FE, Italy.
authors: Rita
authors: R
authors: Pavasini
authors: Department of Medical Science, University of Ferrara, Ferrara, Italy.
authors: Elisa
authors: E
authors: Maietti
authors: Cardiology Unit, Cardiovascular Institute, Azienda Ospedaliero-Universitaria di Ferrara, Via Aldo Moro, 8, 44124, Cona, FE, Italy.
authors: Elisabetta
authors: E
authors: Tonet
authors: Cardiology Unit, Cardiovascular Institute, Azienda Ospedaliero-Universitaria di Ferrara, Via Aldo Moro, 8, 44124, Cona, FE, Italy.
authors: Paolo
authors: P
authors: Cimaglia
authors: Cardiology Unit, Cardiovascular Institute, Azienda Ospedaliero-Universitaria di Ferrara, Via Aldo Moro, 8, 44124, Cona, FE, Italy.
authors: Giulia
authors: G
authors: Scillitani
authors: Cardiology Unit, Cardiovascular Institute, Azienda Ospedaliero-Universitaria di Ferrara, Via Aldo Moro, 8, 44124, Cona, FE, Italy.
authors: Giulia
authors: G
authors: Bugani
authors: Cardiology Unit, Cardiovascular Institute, Azienda Ospedaliero-Universitaria di Ferrara, Via Aldo Moro, 8, 44124, Cona, FE, Italy.
authors: Matteo
authors: M
authors: Serenelli
authors: Cardiology Unit, Cardiovascular Institute, Azienda Ospedaliero-Universitaria di Ferrara, Via Aldo Moro, 8, 44124, Cona, FE, Italy.
authors: Fatima
authors: F
authors: Zaraket
authors: Cardiology Unit, Cardiovascular Institute, Azienda Ospedaliero-Universitaria di Ferrara, Via Aldo Moro, 8, 44124, Cona, FE, Italy.
authors: Cristina
authors: C
authors: Balla
authors: Cardiology Unit, Cardiovascular Institute, Azienda Ospedaliero-Universitaria di Ferrara, Via Aldo Moro, 8, 44124, Cona, FE, Italy.
authors: Filippo
authors: F
authors: Trevisan
authors: Cardiology Unit, Cardiovascular Institute, Azienda Ospedaliero-Universitaria di Ferrara, Via Aldo Moro, 8, 44124, Cona, FE, Italy.
authors: Simone
authors: S
authors: Biscaglia
authors: Division of Cardiology, Cento Hospital, Ferrara, Italy.
authors: Biagio
authors: B
authors: Sassone
authors: Unità Operativa di Cardiologia, Ospedale GB Morgagni, Forlì, Italy.
authors: Marcello
authors: M
authors: Galvani
authors: Cardiology Unit, Cardiovascular Institute, Azienda Ospedaliero-Universitaria di Ferrara, Via Aldo Moro, 8, 44124, Cona, FE, Italy.|Laboratorio per le Tecnologie delle Terapie Avanzate (LTTA) Center, Ferrara, Italy.|Maria Cecilia Hospital, GVM Care & Research, E.S.: Health Science Foundation, Cotignola, Italy.
authors: Roberto
authors: R
authors: Ferrari
authors: Department of Medical Science, University of Ferrara, Ferrara, Italy.
authors: Stefano
authors: S
authors: Volpato
mesh_terms: D054058:Acute Coronary Syndrome / Q000628:therapy*; D000368:Aged; D005260:Female; D016330:Frail Elderly; D000073496:Frailty / Q000175:diagnosis*; D006760:Hospitalization; D006801:Humans; D008297:Male; D011379:Prognosis; D011446:Prospective Studies; D018570:Risk Assessment
keywords: Acute coronary syndrome; Clinical frailty score; Frailty; Handgrip; Multidimensional performance test; Short physical performance battery