title: Nitrogen-Containing Constituents of Black Cohosh: Chemistry, Structure Elucidation, and Biological Activities.
abstract: The roots/rhizomes of black cohosh (Actaea racemosaL. syn.Cimicifuga racemosa[L]. Nutt., Ranunculaceae) have been used traditionally by Native Americans to treat colds, rheumatism, and a variety of conditions related to women's health. In recent years black cohosh preparations have become popular dietary supplements among women seeking alternative treatments for menopausal complaints. The popularity of the plant has led to extensive phytochemical and biological investigations, including several clinical trials. Most of the phytochemical and biological research has focused on two abundant classes of compounds: the triterpene glycosides and phenolic acids. A third group of phytoconstituents that has received far less attention consists of the alkaloids and related compounds that contain nitrogen. This chapter summarizes the current state of knowledge of the chemistry and biological activities associated with this group of constituents and provides some perspective on their significance for future research on this interesting plant.
authors: UIC/NIH Center for Botanical Dietary Supplements Research, Department of Medicinal Chemistry and Pharmacognosy, University of Illinois College of Pharmacy, 833 S Wood Street, Chicago, IL 60612-7231, USA.
authors: Dejan
authors: D
authors: Nikolić
authors: UIC/NIH Center for Botanical Dietary Supplements Research, Department of Medicinal Chemistry and Pharmacognosy, University of Illinois College of Pharmacy, 833 S Wood Street, Chicago, IL 60612-7231, USA.
authors: David C
authors: DC
authors: Lankin
authors: UIC/NIH Center for Botanical Dietary Supplements Research, Department of Medicinal Chemistry and Pharmacognosy, University of Illinois College of Pharmacy, 833 S Wood Street, Chicago, IL 60612-7231, USA.
authors: Tamara
authors: T
authors: Cisowska
authors: UIC/NIH Center for Botanical Dietary Supplements Research, Department of Medicinal Chemistry and Pharmacognosy, University of Illinois College of Pharmacy, 833 S Wood Street, Chicago, IL 60612-7231, USA.
authors: Shao-Nong
authors: SN
authors: Chen
authors: UIC/NIH Center for Botanical Dietary Supplements Research, Department of Medicinal Chemistry and Pharmacognosy, University of Illinois College of Pharmacy, 833 S Wood Street, Chicago, IL 60612-7231, USA.
authors: Guido F
authors: GF
authors: Pauli
authors: UIC/NIH Center for Botanical Dietary Supplements Research, Department of Medicinal Chemistry and Pharmacognosy, University of Illinois College of Pharmacy, 833 S Wood Street, Chicago, IL 60612-7231, USA.
authors: Richard B
authors: RB
authors: van Breemen
keywords: 5-HT7 receptor; Acylated arginines; Alkaloids; Aporphine alkaloids; Arginine; Benzylisoquinoline alkaloids; Betains; Black cohosh; Choline; Cimicifuga racemosa; Cimipronidine; Cinnamides; Guanidino alkaloids; Indole alkaloids; Isoquinoline alkaloids; Magnoflorine; MassBank; Methylcimitrypazepine; Monoamine oxidase; N-Feruloyl arginine; N-Feruloyl tyramine glucoside; Nω-Methylserotonin; Pictet-Spengler reaction; Protoberberine alkaloids; Protopine; Reticuline; Salsolinol; Trigonelline; Triterpene glycosides; β-Carbolines; γ-Guanidinobutyric acid