title: Ocular Pharmacokinetics.
abstract: Although the fundamental concepts of pharmacokinetics remain the same, ocular pharmacokinetics has its own challenges due to the uniqueness of barrier properties posed by various ocular tissues and its growing complexity with different routes of ocular administration. A thorough understanding of the barrier nature will aid in tailoring a drug or its carrier's physicochemical properties to its advantage. In order to deliver the right payload of a drug at the target site, various approaches can be taken to leverage the pharmacokinetics that includes molecular design based on desirable physicochemical properties, formulation approaches, and alternative routes of administration. In this chapter, a brief overview of the barrier properties with respect to various routes of administration is presented along with the physicochemical properties that influence the pharmacokinetics of ocular drugs. Recent advances in ocular pharmacokinetics are discussed in addition to new perspectives in interpreting existing data.
authors: Pfizer - Clinical Pharmacology, 10555 Science Center Drive, San Diego, CA, 92121, USA. Chandra.Durairaj@Pfizer.com.
authors: Chandrasekar
authors: C
authors: Durairaj
mesh_terms: D016503:Drug Delivery Systems; D005123:Eye / Q000187:drug effects*; D006801:Humans; D010599:Pharmacokinetics
keywords: Anterior segment; Disposition; Intracameral; Intravitreal; Pharmacokinetics; Posterior segment; Topical