title: Emerging Skin T-Cell Functions in Response to Environmental Insults.
abstract: Skin is the primary barrier between the body and the outside world, functioning not only as a physical barrier, but also as an immunologic first line of defense. A large number of T cells populate the skin. This review highlights the ability of these cutaneous T cells to regulate skin-specific environmental threats, including microbes, injuries, solar UV radiation, and allergens. Since much of this knowledge has been advanced from murine studies, we focus our review on how the mouse state has informed the human state, emphasizing the key parallels and differences.
authors: Department of Dermatology, Duke University Medical Center, Durham, North Carolina, USA.
authors: Jutamas
authors: J
authors: Suwanpradid
authors: Department of Dermatology, Duke University Medical Center, Durham, North Carolina, USA; Duke University School of Medicine, Durham, North Carolina, USA.
authors: Zachary E
authors: ZE
authors: Holcomb
authors: Department of Dermatology, Duke University Medical Center, Durham, North Carolina, USA; Department of Immunology, Duke University Medical Center, Durham, North Carolina, USA; Pinnell Center for Investigative Dermatology and Skin Disease Research Center, Duke University Medical Center, Durham, North Carolina, USA. Electronic address: Amanda.MacLeod@duke.edu.
authors: Amanda S
authors: AS
authors: MacLeod
mesh_terms: D000818:Animals; D017449:Dermatitis, Allergic Contact / Q000209:etiology; D003875:Drug Eruptions / Q000209:etiology; D006801:Humans; D051379:Mice; D064307:Microbiota; D012867:Skin / Q000276:immunology* / Q000528:radiation effects; D013601:T-Lymphocytes / Q000276:immunology*; D014466:Ultraviolet Rays; D014945:Wound Healing