title: Bedside to bench to bedside research: Estrogen receptor beta ligand as a candidate neuroprotective treatment for multiple sclerosis.
abstract: Protective effects of pregnancy during MS have led to clinical trials of estriol, the pregnancy estrogen, in MS. Since estriol binds to estrogen receptor (ER) beta, ER beta ligand could represent a "next generation estriol" treatment. Here, ER beta ligand treatment was protective in EAE in both sexes and across genetic backgrounds. Neuroprotection was shown in spinal cord, sparing myelin and axons, and in brain, sparing neurons and synapses. Longitudinal in vivo MRIs showed decreased brain atrophy in cerebral cortex gray matter and cerebellum during EAE. Investigation of ER beta ligand as a neuroprotective treatment for MS is warranted.
authors: Department of Neurology, University of California, Los Angeles, David Geffen School of Medicine, USA.
authors: Noriko
authors: N
authors: Itoh
authors: Department of Neurology, University of California, Los Angeles, David Geffen School of Medicine, USA.
authors: Roy
authors: R
authors: Kim
authors: Department of Neurology, University of California, Los Angeles, David Geffen School of Medicine, USA.
authors: Mavis
authors: M
authors: Peng
authors: Department of Neurology, University of California, Los Angeles, David Geffen School of Medicine, USA.
authors: Emma
authors: E
authors: DiFilippo
authors: Department of Neurology, University of California, Los Angeles, David Geffen School of Medicine, USA.
authors: Hadley
authors: H
authors: Johnsonbaugh
authors: Department of Neurology, University of California, Los Angeles, David Geffen School of Medicine, USA.
authors: Allan
authors: A
authors: MacKenzie-Graham
authors: Department of Neurology, University of California, Los Angeles, David Geffen School of Medicine, USA. Electronic address: rvoskuhl@ucla.edu.
authors: Rhonda R
authors: RR
authors: Voskuhl
mesh_terms: D000818:Animals; D003510:Cyclohexanes / Q000008:administration & dosage* / Q000378:metabolism*; D047629:Estrogen Receptor beta / Q000378:metabolism*; D005260:Female; D008024:Ligands; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D016688:Mice, Inbred NOD; D009103:Multiple Sclerosis / Q000378:metabolism* / Q000517:prevention & control; D018696:Neuroprotective Agents / Q000008:administration & dosage* / Q000378:metabolism*; D010636:Phenols / Q000008:administration & dosage* / Q000378:metabolism*; D016896:Treatment Outcome
chemical_list: C587712:AC-186; D003510:Cyclohexanes; D047629:Estrogen Receptor beta; D008024:Ligands; D018696:Neuroprotective Agents; D010636:Phenols
keywords: Estrogen; Experimental autoimmune encephalomyelitis; Multiple sclerosis; Neuroprotection; Pregnancy