title: Acmella oleraceaandAchyrocline satureioidesas Sources of Natural Products in Topical Wound Care.
abstract: The Brazilian forests have one of the world's biggest biodiversities.Achyrocline satureioides(macela) andAcmella oleracea(jambu) are native species from Brazil with a huge therapeutic potential, with proved anti-inflammatory and anesthetic action, respectively. The jambu's crude extract after depigmentation with activated charcoal and macela's essential oil were incorporated in a film made with hydroxyethyl cellulose. Those films were evaluated by mechanical test using a texturometer and anti-inflammatory and anesthetic activities byin vivotests: wound healing and antinociceptive. The film containing the highest concentration of depigmented jambu's extract and macela's essential oil obtained an anesthesia time of 83.6 (±28.5) min longer when compared with the positive control EMLA®; the same occurred with the wound healing test; the film containing the highest concentration had a higher wound contraction (62.0% ± 12.1) compared to the positive control allantoin and the histopathological analysis demonstrated that it increases collagen synthesis and epidermal thickening. The results demonstrate that the films have a potential use in skin wounds, pressure sore, and infected surgical wounds treatment.
authors: Chemical, Biological and Agricultural Research Center (CPQBA), University of Campinas, Campinas, SP, Brazil.
authors: Lais Thiemi
authors: LT
authors: Yamane
authors: Biology Institute, Department of Biochemistry and Tissue Biology, University of Campinas, Campinas, SP, Brazil.
authors: Eneida
authors: E
authors: de Paula
authors: Chemical, Biological and Agricultural Research Center (CPQBA), University of Campinas, Campinas, SP, Brazil.
authors: Michelle Pedroza
authors: MP
authors: Jorge
authors: Chemical, Biological and Agricultural Research Center (CPQBA), University of Campinas, Campinas, SP, Brazil.
authors: Verônica Santana
authors: VS
authors: de Freitas-Blanco
authors: Chemical, Biological and Agricultural Research Center (CPQBA), University of Campinas, Campinas, SP, Brazil.
authors: Ílio Montanari
authors: ÍM
authors: Junior
authors: Chemical, Biological and Agricultural Research Center (CPQBA), University of Campinas, Campinas, SP, Brazil.
authors: Glyn Mara
authors: GM
authors: Figueira
authors: Institute of Biosciences, Department of Biology, Sao Paulo State University, Rio Claro, SP, Brazil.
authors: Luís Adriano
authors: LA
authors: Anholeto
authors: Institute of Biosciences, Department of Biology, Sao Paulo State University, Rio Claro, SP, Brazil.
authors: Patricia Rosa
authors: PR
authors: de Oliveira
authors: Chemical, Biological and Agricultural Research Center (CPQBA), University of Campinas, Campinas, SP, Brazil.
authors: Rodney Alexandre Ferreira
authors: 0000-0001-5631-0970
authors: RA
authors: Rodrigues