title: Pyranochromones from Dictyoloma vandellianum A. Juss and Their Cytotoxic Evaluation.
abstract: One new chromone 3,3-dimethylallylspatheliachromene methyl ether (1), as well as five known chromones, 6-(3-methylbut-2-enyl) allopteroxylin methyl ether (2), 6-(3-methylbut-2-enyl) allopteroxylin (3), 3,3-dimethylallylspatheliachromene (4), 5-O-methylcneorumchromone K (5) and spatheliabischromene (6), two alkaloids, 8-methoxy-N-methylflindersine (7) and 8-methoxyflindersine (8), and two limonoids, limonin diosphenol (9) and rutaevin (10), were isolated from Dictyoloma vandellianum A. Juss (Rutaceae). Cytotoxic activities towards tumor cell lines B16-F10, HepG2, K562 and HL60 and non-tumor cells PBMC were evaluated for compounds 1 - 6. Compound 1 was the most active showing IC50values ranging from 6.26 to 14.82 μg/ml in B16-F10 and K562 cell lines, respectively, and presented IC50value of 11.65 μg/ml in PBMC cell line.
authors: Institute of Chemistry, Federal University of Bahia, Barão do Jeremoabo 147, Ondina, 40170-115, Salvador, BA, Brazil.
authors: Iura M
authors: IM
authors: Alves
authors: College of Pharmacy, Federal University of Bahia, Barão do Jeremoabo 147, Ondina, 40170-115, Salvador, BA, Brazil.
authors: Lucas S
authors: LS
authors: Abreu
authors: Gonçalo Moniz Institute, Oswaldo Cruz Foundation, Waldemar Falcão 121, Candeal, 40296-710, Salvador, BA, Brazil.
authors: Cinara O S
authors: CO
authors: Costa
authors: Department of Chemistry, Federal University of Juiz de Fora, José Lourenço Kelmer, S/n, Martelos, 36036-900, Juiz de Fora, MG, Brazil.
authors: Mireille
authors: M
authors: Le Hyaric
authors: Institute of Biology, Federal University of Bahia, Barão do Jeremoabo, 147, Ondina, 40170-115, Salvador, BA, Brazil.
authors: Maria Lenise S
authors: ML
authors: Guedes
authors: Gonçalo Moniz Institute, Oswaldo Cruz Foundation, Waldemar Falcão 121, Candeal, 40296-710, Salvador, BA, Brazil.
authors: Milena B P
authors: MB
authors: Soares
authors: Gonçalo Moniz Institute, Oswaldo Cruz Foundation, Waldemar Falcão 121, Candeal, 40296-710, Salvador, BA, Brazil.
authors: Daniel P
authors: DP
authors: Bezerra
authors: Institute of Chemistry, Federal University of Bahia, Barão do Jeremoabo 147, Ondina, 40170-115, Salvador, BA, Brazil.|College of Pharmacy, Federal University of Bahia, Barão do Jeremoabo 147, Ondina, 40170-115, Salvador, BA, Brazil.
authors: Eudes S
authors: ES
authors: Velozo
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D000818:Animals; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002867:Chromones / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D018922:HL-60 Cells; D056945:Hep G2 Cells; D006801:Humans; D020014:K562 Cells; D007963:Leukocytes, Mononuclear / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D036701:Limonins / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D018515:Plant Leaves / Q000737:chemistry / Q000378:metabolism; D027821:Rutaceae / Q000737:chemistry* / Q000378:metabolism
chemical_list: D000470:Alkaloids; D002867:Chromones; D036701:Limonins
keywords: 
  Dictyoloma
  ; Alkaloids; Chromones; Cytotoxic activities; Limonoids; Rutaceae