title: SirT3 and p53 Deacetylation in Aging and Cancer.
abstract: The mammalian Sirtuins are a family of highly conserved nicotinamide adenine dinucleotide (NAD+)-dependent histone deacetylase. The mammalian Sirtuins family has identified seven different types of sirtuin. Sirtuins 3(SirT3) is localized to mitochondria, and is a multiple functional protein deacylase through deacetylating a variety of substrates. Cellular senescence represents a permanent withdraw from cell cycle in response to diverse stress; it is controlled by the p53 and retinoblastoma protein (RB) tumor suppressors, and constitutes a potent anticancer mechanisms. p53 can be deacetylated by a protein complex containing histone deacetylases (HDAC1). There is possibility that SirT3 may also deacetylate p53. We introduce the recent research on the SirT3-p53 interplay directly and indirectly, and discuss the significance of p53 deacetylation by SirT3 in the aging and cancer. J. Cell. Physiol. 232: 2308-2311, 2017. © 2016 Wiley Periodicals, Inc.
authors: Research and Development, Allonger LLC, Columbia, Maryland.|Mei Chen Biotechnology Co. Ltd., Qingdao, Shan Dong, China.
authors: Jijun
authors: J
authors: Chen
authors: The Affiliated Hospital of Qingdao University, Qingdao, Shan Dong, China.
authors: Aiqin
authors: A
authors: Wang
authors: The Affiliated Hospital of Qingdao University, Qingdao, Shan Dong, China.
authors: Qingqi
authors: Q
authors: Chen
mesh_terms: D000107:Acetylation; D000375:Aging / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D006801:Humans; D008958:Models, Molecular; D009369:Neoplasms / Q000201:enzymology* / Q000473:pathology; D011487:Protein Conformation; D015398:Signal Transduction; D056566:Sirtuin 3 / Q000737:chemistry / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000737:chemistry / Q000378:metabolism*
chemical_list: C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53; C466093:SIRT3 protein, human; D056566:Sirtuin 3