title: BSA Protein-Mediated Synthesis of Hollow Mesoporous Silica Nanotubes, and Their Carbohydrate Conjugates for Targeting Cancer Cells and Detecting Mycobacteria.
abstract: A straightforward method was developed to synthesize hollow mesoporous silica nanotubes (HMSNTs) using bovine serum protein (BSA) as the protective coating and phosphate buffered saline (PBS) as the etching agent at room temperature. Galactose-grafted HMSNTs significantly reduced phagocytosis by macrophages, and enhanced cellular uptake by A549 cells via caveolae-mediated uptake pathway. Trehalose-conjugated HMSNTs interacted strongly with mycobacteria, showing the linear detection range from 1 × 104to 1 × 108bacteria/mL and the detection limit of 1 × 103bacteria/mL. In all cases, the hollow nanotube structure showed higher cellular uptake, bacterial binding, and detection efficiency than their spherical counterpart.
authors: Technical Institute of Physics and Chemistry, Chinese Academy of Sciences , Beijing 100190, P. R. China.|Thayer School of Engineering, Dartmouth College , Hanover, New Hampshire 03755, United States.
authors: Nanjing
authors: N
authors: Hao
authors: Technical Institute of Physics and Chemistry, Chinese Academy of Sciences , Beijing 100190, P. R. China.
authors: Laifeng
authors: L
authors: Li
authors: Technical Institute of Physics and Chemistry, Chinese Academy of Sciences , Beijing 100190, P. R. China.
authors: Fangqiong
authors: F
authors: Tang
mesh_terms: D000818:Animals; D002241:Carbohydrates; D009161:Mycobacterium; D043942:Nanotubes; D016062:Porosity; D012710:Serum Albumin, Bovine; D012822:Silicon Dioxide
chemical_list: D002241:Carbohydrates; D012710:Serum Albumin, Bovine; D012822:Silicon Dioxide
keywords: carbohydrate; detection; hollow mesoporous silica; mycobacteria; targeting