title: Association of plasma arginine with breast cancer molecular subtypes in women of Liaoning province.
abstract: Arginine is one of the human nonessential amino acids critical for the growth of human cancers. The aim of this study is to investigate the variation of arginine between breast cancer (BC) patients and benign mammary gland disease (control) patients to determine its value in predicting the risk of BC. We also explore the associations between arginine levels and breast cancer subtypes. Preoperative blood samples were obtained from 267 patients (102 BC and 165 controls) in 2015. Plasma arginine values were determined for all preoperative blood samples using liquid chromatography-tandem mass spectrometry (LC-MS/MS) to analyse differences in arginine levels between BC patients and control patients and the correlations between arginine and clinicopathologic parameters in BC. The arginine levels of BC patients were significantly lower than those of control patients (5.96 [3.76-12.47] vs. 12.54 [7.14-24.94], P = 0.000). The area under the curve (AUC) for arginine was 0.721 (95% CI, 0.660-0.782, P < 0.0001). The concentration of arginine was significantly different among different molecular BC subtypes (P = 0.030). Our results suggested that plasma arginine was associated with breast cancer molecular subtypes. © 2016 IUBMB Life, 68(12):980-984, 2016.
authors: Cancer Center, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, People's Republic of China.
authors: Lu
authors: L
authors: Hu
authors: Cancer Center, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, People's Republic of China.
authors: Yu
authors: Y
authors: Gao
authors: Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, People's Republic of China.|Runsheng Kangtai Biomedical Technology Co. Ltd, Jinzhou, People's Republic of China.
authors: Yunfeng
authors: Y
authors: Cao
authors: Cancer Center, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, People's Republic of China.
authors: Yinxu
authors: Y
authors: Zhang
authors: Cancer Center, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, People's Republic of China.
authors: Minghao
authors: M
authors: Xu
authors: Cancer Center, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, People's Republic of China.
authors: Yuanyuan
authors: Y
authors: Wang
authors: Cancer Center, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, People's Republic of China.
authors: Yu
authors: Y
authors: Jing
authors: Cancer Center, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, People's Republic of China.
authors: Shengnan
authors: S
authors: Guo
authors: Cancer Center, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, People's Republic of China.
authors: Fangyu
authors: F
authors: Jing
authors: Cancer Center, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, People's Republic of China.
authors: Xiaodan
authors: X
authors: Hu
authors: Cancer Center, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, People's Republic of China.
authors: Zhitu
authors: Z
authors: Zhu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019540:Area Under Curve; D001120:Arginine / Q000097:blood*; D014408:Biomarkers, Tumor / Q000097:blood*; D001943:Breast Neoplasms / Q000097:blood* / Q000175:diagnosis*; D016022:Case-Control Studies; D002681:China; D005260:Female; D006801:Humans; D008875:Middle Aged; D012372:ROC Curve
chemical_list: D014408:Biomarkers, Tumor; D001120:Arginine
keywords: arginine; biomarkers; breast cancer; molecular subtypes