title: An improved polymeric sponge replication method for biomedical porous titanium scaffolds.
abstract: Biomedical porous titanium (Ti) scaffolds were fabricated by an improved polymeric sponge replication method. The unique formulations and distinct processing techniques, i.e. a mixture of water and ethanol as solvent, multiple coatings with different viscosities of the Ti slurries and centrifugation for removing the extra slurries were used in the present study. The optimized porous Ti scaffolds had uniform porous structure and completely interconnected macropores (~365.1μm). In addition, two different sizes of micropores (~45.4 and ~6.2μm) were also formed in the skeleton of the scaffold. The addition of ethanol to the Ti slurry increased the compressive strength of the scaffold by improving the compactness of the skeleton. A compressive strength of 83.6±4.0MPa was achieved for a porous Ti scaffold with a porosity of 66.4±1.8%. Our cellular study also revealed that the scaffolds could support the growth and proliferation of mesenchymal stem cells (MSCs).
authors: National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China.
authors: Chunli
authors: C
authors: Wang
authors: National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China.
authors: Hongjie
authors: H
authors: Chen
authors: National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China. Electronic address: zxd7303@163.com.
authors: Xiangdong
authors: X
authors: Zhu
authors: National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China.
authors: Zhanwen
authors: Z
authors: Xiao
authors: National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China. Electronic address: kaizhang@scu.edu.cn.
authors: Kai
authors: K
authors: Zhang
authors: National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China.
authors: Xingdong
authors: X
authors: Zhang
mesh_terms: D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D019245:Compressive Strength / Q000187:drug effects; D000431:Ethanol / Q000032:analysis; D059630:Mesenchymal Stem Cells / Q000166:cytology; D011108:Polymers / Q000494:pharmacology*; D011142:Polyvinyl Alcohol / Q000032:analysis; D011161:Porifera / Q000737:chemistry*; D016062:Porosity; D011817:Rabbits; D013314:Stress, Mechanical; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds / Q000737:chemistry*; D014025:Titanium / Q000494:pharmacology*; D014783:Viscosity
chemical_list: D011108:Polymers; D000431:Ethanol; D011142:Polyvinyl Alcohol; D014025:Titanium
keywords: Ethanol; Multiple coatings; Porous scaffold; Sponge replication; Titanium