title: Glucose-bearing biodegradable poly(amino acid) and poly(amino acid)-poly(ester) conjugates for controlled payload release.
abstract: The glucoseamine-initiated ring-opening polymerisation of amino acid N-carboxyanhydrides and O-carboxanhydrides to yield amphiphilic block copolymers that are capable of self-assembly in aqueous solution to form well-defined, glucose-presenting, particles is reported. The particles formed are susceptible to enzyme-mediated (lipase and protease) and pH-induced degradation, and can selectively bind the lectin concanavalin A. Consequently, such glycoparticles are of significance for the controlled release of payload molecules in response to an acidic environment, for instance cancerous tissue, and upon interaction with target enzymes.
authors: School of Chemistry, University of Leeds, Woodhouse Lane, Leeds, LS2 9JT, UK. paul.d.thornton@leeds.ac.uk.
authors: Mthulisi
authors: M
authors: Khuphe
authors: School of Chemistry, University of Leeds, Woodhouse Lane, Leeds, LS2 9JT, UK. paul.d.thornton@leeds.ac.uk.
authors: Clare S
authors: CS
authors: Mahon
authors: School of Chemistry, University of Leeds, Woodhouse Lane, Leeds, LS2 9JT, UK. paul.d.thornton@leeds.ac.uk.
authors: Paul D
authors: PD
authors: Thornton
mesh_terms: D000812:Anhydrides / Q000737:chemistry*; D063566:Biodegradable Plastics; D003208:Concanavalin A / Q000737:chemistry; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry*; D065546:Drug Liberation; D005947:Glucose / Q000737:chemistry*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D037102:Lectins / Q000737:chemistry; D008049:Lipase / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry; D010316:Particle Size; D010447:Peptide Hydrolases / Q000737:chemistry; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry*; D011091:Polyesters / Q000138:chemical synthesis / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry; D058105:Polymerization; D012235:Rhodamines / Q000737:chemistry; D012521:Sarcosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D013499:Surface Properties
chemical_list: D000812:Anhydrides; D063566:Biodegradable Plastics; D004337:Drug Carriers; D037102:Lectins; D010455:Peptides; D011091:Polyesters; D012235:Rhodamines; D003208:Concanavalin A; C015475:polysarcosine; C012001:polyphenylalanine; D011092:Polyethylene Glycols; D008049:Lipase; D010447:Peptide Hydrolases; D005947:Glucose; C029773:rhodamine B; D012521:Sarcosine