title: The Effect of Locally Delivered Statins on Treating Periodontal Intrabony Defects: A Systematic Review and Meta-Analysis.
abstract: Use of statins on adult patients with chronic periodontitis shows a positive effect on their periodontal status. However, effect of locally delivered statins on periodontal treatment has not yet been systematically analyzed. Hence, the present systematic review and meta-analysis aims to evaluate efficacy of statins on treating localized periodontal intrabony defects (IBDs).
  
  
  
  An electronic search of three databases (PubMed, Embase, and Cumulative Index to Nursing and Allied Health Literature) between January 1, 1965 and March 1, 2016, and a hand search of peer-reviewed journals for relevant articles were performed. Controlled randomized clinical trials (RCTs) and prospective studies with data on comparison between adjunctive locally delivered statin use to mechanical scaling and root planing (SRP) and placebo in each group, with minimum 10 participants and follow-up period of at least 6 months, were included.
  
  
  
  Ten studies, eight RCTs and two prospective studies, were included. Each study included 15 to 105 patients between 25 and 55 years of age. Statistical results were recorded; weighted mean difference (WMD) and confidence interval (CI) were calculated; and meta-analyses were performed for defect fill, probing depth (PD) reduction, and clinical attachment level (CAL) gain in both statin and placebo/no treatment groups. Overall analysis of defect fill presented WMD of 1.37 mm (95% CI = 0.96 to 1.77; P <0.0001), PD reduction presented WMD of 1.76 mm (95% CI = 1.04 to 2.47; P <0.0001), and CAL gain presented WMD of 1.58 mm (95% CI = 0.89 to 2.28; P <0.0001). However, comparison presented considerable heterogeneity among studies.
  
  
  
  This systematic review and meta-analysis find that adjunctive use of locally delivered statins to mechanical SRP is beneficial to increasing bone fill percentage. Improved inflammatory and bleeding control as well as PD reduction and CAL gain are possible advantages to using these drugs in treating patients with periodontal IBDs.
authors: Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI.
authors: Khaled
authors: K
authors: Sinjab
authors: Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI.
authors: Nouf
authors: N
authors: Zimmo
authors: Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI.|Department of Surgical Sciences, Marquette University School of Dentistry, Milwaukee, WI.
authors: Guo-Hao
authors: GH
authors: Lin
authors: Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI.
authors: Ming-Pang
authors: MP
authors: Chung
authors: Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI.
authors: Lujain
authors: L
authors: Shaikh
authors: Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI.
authors: Hom-Lay
authors: HL
authors: Wang
mesh_terms: D016301:Alveolar Bone Loss / Q000188:drug therapy; D055113:Chronic Periodontitis / Q000188:drug therapy*; D012534:Dental Scaling; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D016745:Root Planing
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors
keywords: Alveolar bone loss; hydroxymethylglutaryl-CoA reductase inhibitors; meta-analysis as topic; periodontitis; review literature as topic