title: Self-induced intracerebral gamma oscillations in the human cortex.
abstract: Gamma oscillations play a pivotal role in multiple cognitive functions. They enable coordinated activity and communication of local assemblies, while abnormalities in gamma oscillations exist in different neurological and psychiatric diseases. Thus, a specific rectification of gamma synchronization could potentially compensate the deficits in pathological conditions. Previous experiments have shown that animals can voluntarily modulate their gamma power through operant conditioning. Using a closed-loop experimental setup, we show in six intracerebrally recorded epileptic patients undergoing presurgical evaluation that intracerebral power spectrum can be increased in the gamma frequency range (30-80 Hz) at different fronto-temporal cortical sites in human subjects. Successful gamma training was accompanied by increased gamma power at other cortical locations and progressively enhanced cross-frequency coupling between gamma and slow oscillations (3-12 Hz). Finally, using microelectrode targets in two subjects, we report that upregulation of gamma activities is possible also in spatial micro-domains, without the spread to macroelectrodes. Overall, our findings indicate that intracerebral gamma modulation can be achieved rapidly, beyond the motor system and with high spatial specificity, when using micro targets. These results are especially significant because they pave the way for use of high-resolution therapeutic approaches for future clinical applications.
authors: 1 Institut du Cerveau et de la Moelle Epinière, INSERM UMR S 1127, CNRS UMR 7225, UPMC Hôpital de la Pitié-Salpêtrière, Paris France quyen@t-online.de juliana.corlier@gmail.com.|2 Sorbonne University, UPMC - Paris 6, F-75005, Paris, France.
authors: Juliana
authors: J
authors: Corlier
authors: 1 Institut du Cerveau et de la Moelle Epinière, INSERM UMR S 1127, CNRS UMR 7225, UPMC Hôpital de la Pitié-Salpêtrière, Paris France.|2 Sorbonne University, UPMC - Paris 6, F-75005, Paris, France.
authors: Daphné
authors: D
authors: Rimsky-Robert
authors: 3 Department of Biomedical Engineering, Universidad de Los Andes, Bogotá D.C., Colombia.
authors: Mario
authors: M
authors: Valderrama
authors: 1 Institut du Cerveau et de la Moelle Epinière, INSERM UMR S 1127, CNRS UMR 7225, UPMC Hôpital de la Pitié-Salpêtrière, Paris France.|2 Sorbonne University, UPMC - Paris 6, F-75005, Paris, France.|4 Centre de NeuroImagerie de Recherche - CENIR, Institut du Cerveau et de la Moelle Epinière, UPMC-Paris 6, INSERM UMR S 1127 CNRS 7225, Hôpital Pitié-Salpêtrière, Paris, France.
authors: Katia
authors: K
authors: Lehongre
authors: 1 Institut du Cerveau et de la Moelle Epinière, INSERM UMR S 1127, CNRS UMR 7225, UPMC Hôpital de la Pitié-Salpêtrière, Paris France.|2 Sorbonne University, UPMC - Paris 6, F-75005, Paris, France.|5 AP-HP, GH Pitié-Salpêtrière, Epilepsy Unit, F-75013, Paris, France.
authors: Claude
authors: C
authors: Adam
authors: 1 Institut du Cerveau et de la Moelle Epinière, INSERM UMR S 1127, CNRS UMR 7225, UPMC Hôpital de la Pitié-Salpêtrière, Paris France.|2 Sorbonne University, UPMC - Paris 6, F-75005, Paris, France.|6 AP-HP, GH Pitié-Salpêtrière, Neurosurgery Department, F-75013, Paris, France.
authors: Stéphane
authors: S
authors: Clémenceau
authors: 1 Institut du Cerveau et de la Moelle Epinière, INSERM UMR S 1127, CNRS UMR 7225, UPMC Hôpital de la Pitié-Salpêtrière, Paris France.|2 Sorbonne University, UPMC - Paris 6, F-75005, Paris, France.
authors: Stéphane
authors: S
authors: Charpier
authors: 7 Univ. Grenoble Alpes, Grenoble Institut des Neurosciences, GIN, F-38000 Grenoble, France.|8 INSERM, U1216, F-38000 Grenoble, France.
authors: Julien
authors: J
authors: Bastin
authors: 9 Neurology Department, Grenoble Alpes Hospital, F-38000 Grenoble, France.
authors: Philippe
authors: P
authors: Kahane
authors: 10 INSERM 1028, CNRS UMR 5292, Brain Dynamics and Cognition Team, Lyon Neuroscience Research Center, University Claude Bernard Lyon 1, F-69500 Bron, France.
authors: Jean-Philippe
authors: JP
authors: Lachaux
authors: 1 Institut du Cerveau et de la Moelle Epinière, INSERM UMR S 1127, CNRS UMR 7225, UPMC Hôpital de la Pitié-Salpêtrière, Paris France.|2 Sorbonne University, UPMC - Paris 6, F-75005, Paris, France.|5 AP-HP, GH Pitié-Salpêtrière, Epilepsy Unit, F-75013, Paris, France.
authors: Vincent
authors: V
authors: Navarro
authors: 1 Institut du Cerveau et de la Moelle Epinière, INSERM UMR S 1127, CNRS UMR 7225, UPMC Hôpital de la Pitié-Salpêtrière, Paris France quyen@t-online.de juliana.corlier@gmail.com.|2 Sorbonne University, UPMC - Paris 6, F-75005, Paris, France.
authors: Michel
authors: M
authors: Le Van Quyen
mesh_terms: D000328:Adult; D000069280:Electrocorticography / Q000379:methods*; D004567:Electrodes, Implanted; D004827:Epilepsy / Q000503:physiopathology / Q000601:surgery; D056228:Feedback, Sensory / Q000502:physiology*; D005625:Frontal Lobe / Q000502:physiology*; D065818:Gamma Rhythm / Q000502:physiology*; D006801:Humans; D058765:Neurofeedback / Q000379:methods*; D013702:Temporal Lobe / Q000502:physiology*
keywords: gamma oscillations; intracranial EEG; intrinsic plasticity regulation; neurofeedback; non-pharmacological treatment