title: Nanoparticle-based drug delivery in cancer: the role of cell membrane structures.
abstract: Development of novel drug-delivery systems aims to specifically deliver anticancer drugs to tumor tissues and improve the efficiency of chemotherapy, while minimizing side effects of drugs on healthy tissues and organs. However, drug-delivery systems are confronted by membrane barriers and multiple drug resistance in cancer cells. In recent years, the obtained results indicate an important role of lipids, proteins and carbohydrates in apoptosis, drug transport and the process of cellular uptake of nanoparticles via endocytosis. This article discusses the hypothesis of the relationship between cell membrane structure and nanoparticles in cancer cells.
authors: Department of Food Engineering, Ahi Evran University, Kırsehir, Turkey.
authors: Serap
authors: S
authors: Yalçın
authors: Department of Advanced Technology, Ahi Evran University, Kırsehir, Turkey.
authors: Özlem
authors: Ö
authors: Özlüer
authors: Department of Biology, Middle East Technical University, Ankara, Turkey.
authors: Ufuk
authors: U
authors: Gündüz
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage*; D021961:Cell Membrane Structures; D016503:Drug Delivery Systems; D006801:Humans; D053758:Nanoparticles; D009369:Neoplasms / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents
keywords: cancer; cell membrane structures; nanoparticles