title: Malaria: Biology and Disease.
abstract: Malaria has been a major global health problem of humans through history and is a leading cause of death and disease across many tropical and subtropical countries. Over the last fifteen years renewed efforts at control have reduced the prevalence of malaria by over half, raising the prospect that elimination and perhaps eradication may be a long-term possibility. Achievement of this goal requires the development of new tools including novel antimalarial drugs and more efficacious vaccines as well as an increased understanding of the disease and biology of the parasite. This has catalyzed a major effort resulting in development and regulatory approval of the first vaccine against malaria (RTS,S/AS01) as well as identification of novel drug targets and antimalarial compounds, some of which are in human clinical trials.
authors: Walter and Eliza Hall Institute of Medical Research, Melbourne 3051, Australia; Department of Medical Biology, University of Melbourne, Melbourne 3052, Australia. Electronic address: cowman@wehi.edu.au.
authors: Alan F
authors: AF
authors: Cowman
authors: Walter and Eliza Hall Institute of Medical Research, Melbourne 3051, Australia.
authors: Julie
authors: J
authors: Healer
authors: Walter and Eliza Hall Institute of Medical Research, Melbourne 3051, Australia; Department of Medical Biology, University of Melbourne, Melbourne 3052, Australia.
authors: Danushka
authors: D
authors: Marapana
authors: Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Headington, Oxford OX3 7BN, UK. Electronic address: kevin.marsh@ndm.ox.ac.uk.
authors: Kevin
authors: K
authors: Marsh
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D000962:Antimalarials / Q000627:therapeutic use; D003140:Communicable Disease Control / Q000379:methods; D009033:Culicidae / Q000469:parasitology; D060740:Disease Eradication / Q000379:methods; D004351:Drug Resistance; D004912:Erythrocytes / Q000469:parasitology; D014943:Global Health; D006790:Host-Parasite Interactions / Q000276:immunology; D006801:Humans; D008018:Life Cycle Stages; D008099:Liver / Q000469:parasitology; D017780:Malaria Vaccines / Q000276:immunology; D016778:Malaria, Falciparum / Q000276:immunology / Q000469:parasitology / Q000517:prevention & control / Q000635:transmission; D052940:Merozoites / Q000254:growth & development; D010963:Plasmodium falciparum / Q000254:growth & development* / Q000276:immunology; D034101:Sporozoites / Q000254:growth & development; D014614:Vaccines, Synthetic / Q000276:immunology
chemical_list: D000962:Antimalarials; D017780:Malaria Vaccines; C577001:RTS,S-AS01 vaccine; D014614:Vaccines, Synthetic