title: Structural and Functional Analysis of the Small Intestine in Rats After Six-Month-Long Exposure to Multiwalled Carbon Nanotubes.
abstract: Structural and functional analysis of the small intestinal villi in outbred rats was performed after treatment with multiwalled carbon nanotube suspension in comparison with the effects of fine charcoal suspension. Chronic (6 months) exposure to nanotubes in a concentration of 0.2 mg/liter and, particularly, 0.5 mg/liter induced significant changes in the small intestine manifested in a decrease in the number of villi without changes in the brush border integrity, increase in the number of destructed villi, and appearance of villi with apical necrosis. These abnormalities were not observed after treatment for a shorter period of time (2 months).
authors: A. N. Sysin Research Institute of Human Ecology and Environmental Hygiene, Ministry of Health of the Russian Federation, Moscow, Russia.
authors: N N
authors: NN
authors: Belyaeva
authors: A. N. Sysin Research Institute of Human Ecology and Environmental Hygiene, Ministry of Health of the Russian Federation, Moscow, Russia.
authors: L P
authors: LP
authors: Sycheva
authors: A. N. Sysin Research Institute of Human Ecology and Environmental Hygiene, Ministry of Health of the Russian Federation, Moscow, Russia. savon05@yandex.ru.
authors: O N
authors: ON
authors: Savostikova
mesh_terms: D000818:Animals; D002606:Charcoal / Q000494:pharmacology; D007413:Intestinal Mucosa / Q000187:drug effects* / Q000648:ultrastructure; D007421:Intestine, Small / Q000187:drug effects* / Q000648:ultrastructure; D008297:Male; D008871:Microvilli / Q000187:drug effects* / Q000648:ultrastructure; D037742:Nanotubes, Carbon / Q000009:adverse effects*; D051381:Rats; D013535:Suspensions; D013997:Time Factors
chemical_list: D037742:Nanotubes, Carbon; D013535:Suspensions; D002606:Charcoal
keywords: multiwalled carbon nanotubes; small intestine villi in rats