title: Semiconductor technology in protein kinase research and drug discovery: sensing a revolution.
abstract: Since the discovery of protein kinase activity in 1954, close to 600 kinases have been discovered that have crucial roles in cell physiology. In several pathological conditions, aberrant protein kinase activity leads to abnormal cell and tissue physiology. Therefore, protein kinase inhibitors are investigated as potential treatments for several diseases, including dementia, diabetes, cancer and autoimmune and cardiovascular disease. Modern semiconductor technology has recently been applied to accelerate the discovery of novel protein kinase inhibitors that could become the standard-of-care drugs of tomorrow. Here, we describe current techniques and novel applications of semiconductor technologies in protein kinase inhibitor drug discovery.
authors: Department of Electronic & Electrical Engineering, University of Bath, Bath BA2 7AY, UK.
authors: Nikhil
authors: N
authors: Bhalla
authors: Department of Chemical Engineering, University of Bath, Bath BA2 7AY, UK.
authors: Mirella
authors: M
authors: Di Lorenzo
authors: Department of Electronic & Electrical Engineering, University of Bath, Bath BA2 7AY, UK.
authors: Pedro
authors: P
authors: Estrela
authors: Department of Pharmacy & Pharmacology, University of Bath, Bath BA2 7AY, UK. Electronic address: g.pula@bath.ac.uk.
authors: Giordano
authors: G
authors: Pula
mesh_terms: D055808:Drug Discovery; D010766:Phosphorylation; D047428:Protein Kinase Inhibitors; D011494:Protein Kinases / Q000378:metabolism*; D012666:Semiconductors; D020349:Surface Plasmon Resonance
chemical_list: D047428:Protein Kinase Inhibitors; D011494:Protein Kinases