title: Altered regional brain function in the treatment-naive patients with somatic symptom disorder: a resting-state fMRI study.
abstract: Somatic symptom disorder (SSD) is an illness that occurs over a long time and results in significant disruption in daily life. Clinically, SSD patients typically express complaints that involve a variety of organ systems. However, the neural mechanism of SSD remains poorly understood.
  
  
  
  Using resting-state functional magnetic resonance imaging, we investigated the characteristics of the regional basal brain function during resting state in patients with SSD. Eleven treatment-naïve SSD patients and 12 age-matched healthy controls were recruited in this study. Between-group differences in regional homogeneity values were analyzed.
  
  
  
  Compared with the healthy control group, the SSD group showed significant increases in regional homogeneity values in the right medial prefrontal cortex, anterior cingulate cortex and supramarginal gyrus, and significant decreases in the bilateral middle occipital gyrus, superior occipital gyrus and right cuneus and left postcentral gyrus and cerebellum. Meanwhile, the regional homogeneity value of the right medial prefrontal cortex positively correlated with the total duration of SSD.
  
  
  
  The abnormal resting-state patterns in regional brain activity may contribute to understanding the mechanism of SSD.
authors: Department of Radiology Tangdu Hospital the Fourth Military Medical University Xi'an China.
authors: Qiang
authors: Q
authors: Li
authors: Department of Neurosurgery Fuzhou General Hospital Xiamen University Fuzhou China.
authors: Yong
authors: Y
authors: Xiao
authors: Department of Psychosomatics and Psychiatry Affiliated Zhongda Hospital Medical School of Southeast University Nanjing China.
authors: Yinghui
authors: Y
authors: Li
authors: Department of Psychosomatics and Psychiatry Affiliated Zhongda Hospital Medical School of Southeast University Nanjing China.
authors: Lei
authors: L
authors: Li
authors: Department of Psychosomatics and Psychiatry Affiliated Zhongda Hospital Medical School of Southeast University Nanjing China.
authors: Na
authors: N
authors: Lu
authors: Department of Psychosomatics and Psychiatry Affiliated Zhongda Hospital Medical School of Southeast University Nanjing China.
authors: Zhi
authors: Z
authors: Xu
authors: Department of Psychosomatics and Psychiatry Affiliated Zhongda Hospital Medical School of Southeast University Nanjing China.
authors: Xiaodong
authors: X
authors: Mou
authors: Department of Psychosomatics and Psychiatry Affiliated Zhongda Hospital Medical School of Southeast University Nanjing China.
authors: Shenqin
authors: S
authors: Mao
authors: Department of Radiology Tangdu Hospital the Fourth Military Medical University Xi'an China.
authors: Wei
authors: W
authors: Wang
authors: Department of Psychosomatics and Psychiatry Affiliated Zhongda Hospital Medical School of Southeast University Nanjing China.
authors: Yonggui
authors: Y
authors: Yuan
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D001931:Brain Mapping; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012146:Rest; D013001:Somatoform Disorders / Q000000981:diagnostic imaging* / Q000503:physiopathology*
keywords: functional magnetic resonance imaging; medial prefrontal cortex; regional homogeneity; resting state; somatic symptom disorder