title: Effect of nepafenac on the foveal profile of glaucomatous patients undergoing phacoemulsification.
abstract: OBJECTIVE
  Retrospective, pilot study to determine whether nepafenac treatment pre- and postcataract surgery in glaucoma patients using topical hypotensive agents minimized cystoid macular edema by comparing pre- and postsurgical foveal characteristics, as in some cases these agents cannot be withdrawn and, hypothetically, their inflammatory effect on the fovea could be neutralized by the addition of nepafenac.
  
  
  METHODS
  Patients were divided into two subgroups depending on whether or not topical nepafenac was added to the surgical protocol (NEP = nepafenac group and nNEP = non nepafenac group). All had undergone phacoemulsification and data on pre- and postoperative macular status were recorded.
  
  
  RESULTS
  In the nNEP group, there was a significant increase in foveal thickness (FT) in the first month postoperative visit with respect to the preoperative status (p = 0.006), and this situation did not change at the third postoperative month (p = 0.9411). In the NEP group, the increase in FT was not significant at the first month after surgery (p = 0.056) nor at the final visit (p = 0.268), in contrast to the nNEP group.
  
  
  CONCLUSIONS
  This study of the possible prophylactic effect of nepafenac on postoperative macular edema supports the results of other studies that confirm subclinical edema post phacoemulsification, and found a significantly lower gradient in the increase in FT in patients treated pre- and postoperatively with nepafenac.
authors: Glaucoma Unit, Ophthalmology Department, Hospital Clínic de Barcelona, Sabino Arana, 1, 08028, Barcelona, Spain. millagrinoelena@gmail.com.|Glaucoma Unit, Institut Comtal d'Oftalmologia, Barcelona, Spain. millagrinoelena@gmail.com.
authors: Elena
authors: E
authors: Milla
authors: Glaucoma Unit, Institut Comtal d'Oftalmologia, Barcelona, Spain.
authors: Oana
authors: O
authors: Stirbu
authors: Glaucoma Unit, Ophthalmology Department, Complejo Asistencial Universitario de Salamanca, Salamanca, Spain.
authors: Isabel Jimenez
authors: IJ
authors: Franco
authors: Glaucoma Unit, Ophthalmology Department, Complejo Asistencial Universitario de Salamanca, Salamanca, Spain.
authors: Santiago J García
authors: SJG
authors: Hernández
authors: Statistics Department, Hospital Clinic, Barcelona, Spain.
authors: Jose
authors: J
authors: Rios
authors: Glaucoma Unit, Institut Comtal d'Oftalmologia, Barcelona, Spain.
authors: Susana
authors: S
authors: Duch
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage; D000959:Antihypertensive Agents / Q000627:therapeutic use; D044482:Benzeneacetamides / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005500:Follow-Up Studies; D005584:Fovea Centralis / Q000187:drug effects / Q000473:pathology*; D005901:Glaucoma / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D008269:Macular Edema / Q000175:diagnosis / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D018918:Phacoemulsification; D010648:Phenylacetates / Q000008:administration & dosage*; D010865:Pilot Projects; D011183:Postoperative Complications / Q000175:diagnosis / Q000517:prevention & control; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence / Q000379:methods*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000959:Antihypertensive Agents; D044482:Benzeneacetamides; D010648:Phenylacetates; C414203:nepafenac
keywords: Cystoid macular edema; Hypotensive drugs; Nepafenac; Preservatives; Pseudophakic maculopathy