title: Cu-Catalyzed iminative hydroolefination of unactivated alkynes en route to 4-imino-tetrahydropyridines and 4-aminopyridines.
abstract: A general method for synthesizing 4-imino tetrahydropyridine derivatives is achieved, from readily available β-enaminones and sulfonyl azides, which comprises a sequential copper catalyzed ketenimine formation and its hitherto inaccessible intramolecular hydrovinylation. The products are shown as ready precursors for highly valuable 4-sulfonamidopyridine derivatives via DDQ mediated oxidation.
authors: Medicinal & Process Chemistry Division, CSIR-Central Drug Research Institute, BS-10/1, Sector 10, Jankipuram extension, Sitapur Road, Lucknow 226031, India. msreddy@cdri.res.in and Academy of Scientific and Innovative Research, New Delhi 110001, India.
authors: Ravi
authors: R
authors: Kumar
authors: Centre for Materials Characterization, CSIR-NCL, Dr Homi Bhabha Road, Pune-411008, India.
authors: Shridhar H
authors: SH
authors: Thorat
authors: Medicinal & Process Chemistry Division, CSIR-Central Drug Research Institute, BS-10/1, Sector 10, Jankipuram extension, Sitapur Road, Lucknow 226031, India. msreddy@cdri.res.in and Academy of Scientific and Innovative Research, New Delhi 110001, India.
authors: Maddi Sridhar
authors: MS
authors: Reddy