title: Integrating Genomics in Myelodysplastic Syndrome to Predict Outcomes After Allogeneic Hematopoietic Cell Transplantation.
abstract: Myelodysplastic syndrome (MDS) is a heterogeneous group of clonal hematopoietic neoplastic disorders most commonly occurring in the elderly population; MDS has a tendency to progress to acute leukemia. Although epigenetic therapies have improved the outcomes of MDS patients, allogeneic hematopoietic cell transplantation remains the only curative option. Molecular characterization of MDS using next-generation sequencing has expanded not only the knowledge on MDS but also the depth of understanding of evolution and contribution of recurrent somatic mutations in precursor conditions. Rapidly evolving genomic information on MDS may provide clinicians with better risk stratification tools and may also aid in supplying useful information to allow comprehensive therapeutic decision making for MDS patients. In this concise review, we summarize the current knowledge and understanding of recurrent somatic mutations in MDS and discuss salient genomic information predicting response and influencing therapeutic outcomes in the context of allogeneic hematopoietic cell transplantation, as well as the potential application of these findings into future clinical practice.
authors: Department of Internal Medicine, George Washington University, Washington, DC.
authors: Samah
authors: S
authors: Nassereddine
authors: Department of Blood and Marrow Transplantation, Moffitt Cancer Center, Tampa, FL; Department of Oncologic Sciences, University of South Florida Morsani College of Medicine, Tampa, FL.
authors: Taiga
authors: T
authors: Nishihori
authors: Department of Malignant Hematology, Moffitt Cancer Center, Tampa, FL; Department of Oncologic Sciences, University of South Florida Morsani College of Medicine, Tampa, FL.
authors: Eric
authors: E
authors: Padron
authors: Department of Pathology and Laboratory Medicine, American University of Beirut, Beirut, Lebanon.
authors: Rami
authors: R
authors: Mahfouz
authors: Department of Internal Medicine and Bone Marrow Transplant Program, American University of Beirut, Beirut, Lebanon.
authors: Ali
authors: A
authors: Bazarbachi
authors: Department of Malignant Hematology, Moffitt Cancer Center, Tampa, FL; Department of Oncologic Sciences, University of South Florida Morsani College of Medicine, Tampa, FL.
authors: Rami S
authors: RS
authors: Komrokji
authors: Department of Blood and Marrow Transplantation, Moffitt Cancer Center, Tampa, FL; Department of Oncologic Sciences, University of South Florida Morsani College of Medicine, Tampa, FL. Electronic address: Mohamed.Kharfan-Dabaja@Moffitt.org.
authors: Mohamed A
authors: MA
authors: Kharfan-Dabaja
mesh_terms: D023281:Genomics / Q000379:methods; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods; D059014:High-Throughput Nucleotide Sequencing / Q000379:methods; D006801:Humans; D009154:Mutation; D009190:Myelodysplastic Syndromes / Q000188:drug therapy* / Q000235:genetics*; D012306:Risk
keywords: Hematopoietic cell allografting; MDS; Next generation sequencing; Somatic mutation; Survival