title: The Prevalence of Thrombophilia in Women With Recurrent Fetal Loss and Outcome of Anticoagulation Therapy for the Prevention of Miscarriages.
abstract: OBJECTIVE
  To estimate the prevalence of thrombophilia in women with recurrent miscarriages and to assess the effect of antithrombotic therapy.
  
  
  METHODS
  A retrospective cohort study between the years 2004 and 2010.
  
  
  METHODS
  A hypercoagulation community clinic in northern Israel.
  
  
  METHODS
  Four hundred ninety pregnant women referred for thrombophilia screening.
  
  
  METHODS
  Screening results for thrombophilia and antithrombotic treatment with enoxaparin, aspirin, or both and pregnancy outcomes.
  
  
  RESULTS
  The most common thrombophilia in our study group was factor V Leiden mutation with a prevalence of 20.9% followed by protein S deficiency with a prevalence of 19%. Live birth rate was higher in the group of women who received enoxaparin regardless of whether a specific thrombophilia could be found. This finding was more pronounced in women who had ≥4 miscarriages.
  
  
  CONCLUSIONS
  The prevalence of thrombophilia was higher in our study group than in the general population. Furthermore, treatment with enoxaparin might improve the rate of live births in women with or without evidence of thrombophilia, especially in women with ≥4 miscarriages.
authors: 1 Department of Pedeiatrics, Mount Sinai Hospital, New York, NY, USA.
authors: Rawan
authors: R
authors: Nahas
authors: 2 Department of Epidemiology, Carmel Medical Center, Haifa, Israel.
authors: Walid
authors: W
authors: Saliba
authors: 3 Department of Medicine H, Rambam Medical Center, Haifa, Israel.
authors: Adi
authors: A
authors: Elias
authors: 4 Department of Internal Medicine C, Haemek Medical Center, Afula, Israel.
authors: Mazen
authors: M
authors: Elias
mesh_terms: D000026:Abortion, Habitual / Q000175:diagnosis / Q000453:epidemiology / Q000517:prevention & control; D000293:Adolescent; D000328:Adult; D000925:Anticoagulants / Q000008:administration & dosage*; D001241:Aspirin / Q000008:administration & dosage*; D017984:Enoxaparin / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008875:Middle Aged; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology; D015995:Prevalence; D012189:Retrospective Studies; D019851:Thrombophilia / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology
chemical_list: D000925:Anticoagulants; D017984:Enoxaparin; D001241:Aspirin
keywords: antithrombotic treatment; live birth rate; recurrent miscarriages; thrombophilia