title: 18F-FDG PET/CT Can Predict Survival of Advanced Hepatocellular Carcinoma Patients: A Multicenter Retrospective Cohort Study.
abstract: Barcelona Clinic Liver Cancer (BCLC) stage C hepatocellular carcinoma (HCC) consists of a heterogeneous group of patients with a wide range of survival times, requiring further prognostic stratification to facilitate treatment allocation. We evaluated the prognostic value of18F-FDG uptake on PET/CT at the time of presentation in patients with BCLC stage C HCC.Methods:A total of 291 patients with BCLC stage C HCC who underwent18F-FDG PET/CT between 2009 and 2010 for staging were retrospectively enrolled from 7 university hospitals. The patients were further divided into 2 groups according to the extent of disease, as intrahepatic or extrahepatic. Tumor-to-liver SUV ratio (TLR) of the primary tumor was measured on18F-FDG PET/CT. Prognostic values of TLR and other clinical variables were analyzed to predict overall survival (OS) in univariate and multivariate analyses. Differences in the OS stratified by TLR were examined by the Kaplan-Meier method.Results:Higher TLR was associated with extrahepatic disease (P= 0.018). On multivariate analysis, Child-Pugh classification and TLR were independent prognostic factors in the intrahepatic disease group (allP< 0.05), whereas TLR was the only independent prognostic factor in the extrahepatic disease group (P< 0.05). Patients with high TLR showed a significantly worse OS than those with low TLR (P< 0.05) in both groups.Conclusion:In patients with BCLC stage C HCC,18F-FDG uptake in the primary tumor was significantly higher in patients with extrahepatic disease than in those with intrahepatic disease. In addition,18F-FDG uptake on pretreatment PET/CT had an incremental prognostic value for OS in both intrahepatic and extrahepatic disease groups.
authors: Department of Radiology, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
authors: Sae Jung
authors: SJ
authors: Na
authors: Department of Radiology, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Incheon, Korea.
authors: Jin Kyoung
authors: JK
authors: Oh
authors: Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors: Seung Hyup
authors: SH
authors: Hyun
authors: Department of Nuclear Medicine, International St. Mary's Hospital, Catholic Kwandong University College of Medicine, Incheon, Korea.
authors: Jeong Won
authors: JW
authors: Lee
authors: Department of Nuclear Medicine, Kyung Hee University Hospital, School of Medicine, Kyung Hee University, Seoul, Korea.
authors: Il Ki
authors: IK
authors: Hong
authors: Department of Nuclear Medicine, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Korea.
authors: Bong-Il
authors: BI
authors: Song
authors: Department of Nuclear Medicine, Research Institute and Hospital, National Cancer Center, Goyang, Korea.
authors: Tae-Sung
authors: TS
authors: Kim
authors: Department of Nuclear Medicine, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea.
authors: Jae Seon
authors: JS
authors: Eo
authors: Department of Internal Medicine, Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Bucheon, Korea.
authors: Sung Won
authors: SW
authors: Lee
authors: Department of Radiology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea; and.
authors: Ie Ryung
authors: IR
authors: Yoo
authors: Department of Radiology, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Incheon, Korea yunmijin@yuhs.ac yongan@catholic.ac.kr.
authors: Yong An
authors: YA
authors: Chung
authors: Department of Nuclear Medicine, Yonsei University College of Medicine, Seoul, Korea yunmijin@yuhs.ac yongan@catholic.ac.kr.
authors: Mijin
authors: M
authors: Yun
mesh_terms: D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging* / Q000401:mortality* / Q000628:therapy; D015331:Cohort Studies; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D008113:Liver Neoplasms / Q000000981:diagnostic imaging* / Q000401:mortality* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D000072078:Positron Emission Tomography Computed Tomography / Q000379:methods / Q000706:statistics & numerical data*; D015995:Prevalence; D011379:Prognosis; D016016:Proportional Hazards Models; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D056910:Republic of Korea / Q000453:epidemiology; D012189:Retrospective Studies; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D016019:Survival Analysis
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
keywords: 18F-FDG; PET/CT; hepatocellular carcinoma; prognosis; survival