title: Hypothesis: Homologous Recombination Depends on Parallel Search.
abstract: It is not known how a cell manages to find a specific DNA sequence sufficiently fast to repair a broken chromosome through homologous recombination. I propose a solution based on freely diffusing molecules that are programmed with sequences corresponding to those flanking the break site. In such a process, the target search would be parallelized.
authors: Department Cell and Molecular Biology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden. Electronic address: johan.elf@icm.uu.se.
authors: Johan
authors: J
authors: Elf
mesh_terms: D002875:Chromosomes; D004247:DNA; D004249:DNA Damage; D004260:DNA Repair; D059765:Homologous Recombination
chemical_list: D004247:DNA