title: Impact of phosphoproteomics in the translation of kinase-targeted therapies.
abstract: Signaling pathways driven by protein and lipid kinases are altered in most human diseases. Therefore, pharmacological inhibitors of cell signaling are one of the most intensively pursued therapeutic approaches for the treatment of diseases such as cancer, neurodegeneration, and metabolic syndromes. Phosphoproteomics is a technique that measures the products of kinase activities and, with the appropriate bioinformatics techniques, the methodology can also provide measures of kinase pathway activation and network circuitry. Hence, due to recent technological advantages, LC-MS-based quantitative phosphoproteomics provides relevant information for the design and implementation of kinase inhibitor based therapies. Here, we review how phosphoproteome profiling is being used in translational research as a means to identify drug targets and biomarkers for personalizing therapies based on kinase inhibitors.
authors: Cell Signalling and Proteomics Group, Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, UK.
authors: Pedro
authors: P
authors: Casado
authors: Cell Signalling and Proteomics Group, Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, UK.
authors: Maruan
authors: M
authors: Hijazi
authors: Cell Signalling and Proteomics Group, Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, UK.
authors: David
authors: D
authors: Britton
authors: Cell Signalling and Proteomics Group, Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, UK.
authors: Pedro R
authors: PR
authors: Cutillas
mesh_terms: D000818:Animals; D006801:Humans; D058990:Molecular Targeted Therapy; D010750:Phosphoproteins / Q000378:metabolism*; D047428:Protein Kinase Inhibitors / Q000494:pharmacology; D011494:Protein Kinases / Q000378:metabolism*; D040901:Proteomics / Q000379:methods*; D057170:Translational Research, Biomedical
chemical_list: D010750:Phosphoproteins; D047428:Protein Kinase Inhibitors; D011494:Protein Kinases
keywords: Biomarkers; Cancer; Kinase inhibitors; Phosphoproteomics; Technology