title: Effect of dexmedetomidine priming on convulsion reaction induced by lidocaine.
abstract: To study the effect of dexmedetomidine priming on convulsion reaction induced by lidocaine.The New Zealand white rabbits were applied for the mechanism study of dexmedetomidine priming for preventing convulsion reaction induced by lidocaine. The influence of dexmedetomidine priming with different doses on the time for convulsion occurrence and the duration time of convulsion induced by lidocaine, as well as contents of excitatory amino acids (aspartate [Asp], glutamate [Glu]) and inhibitory amino acids (glycine [Gly], γ-aminobutyric acid [GABA]) in the brain tissue were investigated.With 3 and 5 μg/kg dexmedetomidine priming, the occurrence times of convulsion were prolonged from 196 seconds to 349 and 414 seconds, respectively. With dexmedetomidine priming, the contents of excitatory amino acids (Asp, Glu) were much reduced at occurrence time of convulsion comparing with that without dexmedetomidine priming, while content of inhibitory amino acids Gly was much enhanced.The application of dexmedetomidine before local anesthetics can improve intoxication dose threshold of the lidocaine, delay occurrence of the convulsion, and helped for the recovery of convulsion induced by lidocaine. The positive effect of dexmedetomidine on preventing convulsion would owe to not only the inhibition of excitatory amino acids (Asp, Glu), but also the promotion of inhibitory amino acids Gly secretion.
authors: Department of Anesthesia, the First Affiliated Hospital of Nanchang University, Nanchang Department of Anesthesia, the Seventh People' s Hospital of Shenzhen, China.
authors: Xi-Feng
authors: XF
authors: Wang
authors: Xiao-Ling
authors: XL
authors: Luo
authors: Wei-Cheng
authors: WC
authors: Liu
authors: Ben-Chao
authors: BC
authors: Hou
authors: Jian
authors: J
authors: Huang
authors: Yan-Ping
authors: YP
authors: Zhan
authors: Shi-Biao
authors: SB
authors: Chen
mesh_terms: D000287:Administration, Topical; D058647:Adrenergic alpha-2 Receptor Agonists / Q000008:administration & dosage; D000779:Anesthetics, Local / Q000633:toxicity; D000818:Animals; D020927:Dexmedetomidine / Q000008:administration & dosage*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D008012:Lidocaine / Q000633:toxicity*; D008297:Male; D011817:Rabbits; D012640:Seizures / Q000139:chemically induced / Q000517:prevention & control*
chemical_list: D058647:Adrenergic alpha-2 Receptor Agonists; D000779:Anesthetics, Local; D020927:Dexmedetomidine; D008012:Lidocaine