title: Commonly preserved and species-specific gyral folding patterns across primate brains.
abstract: Cortical folding pattern analysis is very important to understand brain organization and development. Since previous studies mostly focus on human brain cortex, the regularity and variability of cortical folding patterns across primate brains (macaques, chimpanzees and human) remain largely unknown. This paper presents a novel computational framework to identify common or unique gyral folding patterns in macaque, chimpanzee and human brains using magnetic resonance imaging (MRI) data. We quantitatively characterize gyral folding patterns via hinge numbers with cortical surfaces constructed from MRI data, and identify 6 common three-hinge gyral folds that exhibit consistent anatomical locations across these three species as well as 2 unique three hinges in macaque, 6 ones in chimpanzee and 14 ones in human. A novel morphology descriptor is then applied to classify three-hinge gyral folds, and the increasing complexity is identified among the species analyzed. This study may provide novel insights into the regularity and variability of the cerebral cortex from developmental perspective and may potentially facilitate novel neuroimage analyses such as cortical parcellation with correspondences across species in the future.
authors: School of Automation, Northwestern Polytechnical University, Xi'an, China.
authors: Xiao
authors: X
authors: Li
authors: Cortical Architecture Imaging and Discovery Lab, Department of Computer Science and Bioimaging Research Center, The University of Georgia, Athens, GA, USA.
authors: Hanbo
authors: H
authors: Chen
authors: School of Automation, Northwestern Polytechnical University, Xi'an, China.|Brain Decoding Research Center, Northwestern Polytechnical University, Xi'an, China.
authors: Tuo
authors: T
authors: Zhang
authors: School of Automation, Northwestern Polytechnical University, Xi'an, China.
authors: Xiang
authors: X
authors: Yu
authors: Cortical Architecture Imaging and Discovery Lab, Department of Computer Science and Bioimaging Research Center, The University of Georgia, Athens, GA, USA.
authors: Xi
authors: X
authors: Jiang
authors: Department of Bioengineering, UC Riverside, Riverside, GA, USA.|West China Hospital of Sichuan University, Chengdu, China.
authors: Kaiming
authors: K
authors: Li
authors: Marcus Autism Center, Emory University, Atlanta, GA, USA.
authors: Longchuan
authors: L
authors: Li
authors: College of Engineering, The University of Georgia, Athens, GA, USA.
authors: Mir Jalil
authors: MJ
authors: Razavi
authors: College of Engineering, The University of Georgia, Athens, GA, USA.
authors: Xianqiao
authors: X
authors: Wang
authors: School of Automation, Northwestern Polytechnical University, Xi'an, China.
authors: Xintao
authors: X
authors: Hu
authors: School of Automation, Northwestern Polytechnical University, Xi'an, China.
authors: Junwei
authors: J
authors: Han
authors: School of Automation, Northwestern Polytechnical University, Xi'an, China.
authors: Lei
authors: L
authors: Guo
authors: Department of Bioengineering, UC Riverside, Riverside, GA, USA.
authors: Xiaoping
authors: X
authors: Hu
authors: Cortical Architecture Imaging and Discovery Lab, Department of Computer Science and Bioimaging Research Center, The University of Georgia, Athens, GA, USA. tliu@cs.uga.edu.
authors: Tianming
authors: T
authors: Liu
mesh_terms: D000465:Algorithms; D000818:Animals; D001921:Brain / Q000033:anatomy & histology*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D021621:Imaging, Three-Dimensional / Q000379:methods; D008251:Macaca; D008279:Magnetic Resonance Imaging / Q000379:methods; D002679:Pan troglodytes; D013045:Species Specificity
keywords: Cortical folding; Magnetic resonance imaging; Primate brains; Three hinges