title: An Evidence-Based Approach to the Management of Functional Dyspepsia Associated With Helicobacter pylori Infection.
abstract: BACKGROUND
  Functional dyspepsia is defined as at least a 3-month history of dyspepsia without structural explanation for the symptoms, and it accounts for most cases of dyspepsia. We designed this study to investigate functional dyspepsia among a Chinese population in Taiwan.
  
  
  METHODS
  Data from the medical records of 1,143 adult patients who underwent transoral upper endoscopy for symptoms of dyspepsia in our hospital were retrospectively analyzed between January 2008 and December 2008. Exclusion criteria were structural gastrointestinal and hepatobiliary abnormalities, prior gastric surgery or history of chronic medication use.
  
  
  RESULTS
  Patients were mainly in the third and fourth decades of life. More female patients were noted than male patients (ratio 2:1). The rate ofHelicobacter pyloriinfection was 18.5%. The rate of response to therapeutic agents, including proton pump inhibitors, H2-receptor antagonists and prokinetic agents, ranged from 69% to 77% among all cases. Patients who underwentH. pylorieradication therapy (88.8%) had a significantly higher rate of symptom improvement than those withoutH. pyloriinfection (77.5%).
  
  
  CONCLUSIONS
  Cases with functional dyspepsia have the characteristics of middle age, female predominance, a relatively lowerH. pyloriinfection rate and a positive response toH. pylorieradication therapy.
authors: Division of Gastroenterology and Hepatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; Department of Medicine, Chung Shan Medical University, Taichung, Taiwan.
authors: Shou-Wu
authors: SW
authors: Lee
authors: Division of Gastroenterology and Hepatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; Department of Internal Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan.
authors: Yen-Chun
authors: YC
authors: Peng
authors: Division of Gastroenterology and Hepatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
authors: Chun-Fang
authors: CF
authors: Tung
authors: Division of Gastroenterology and Hepatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; Department of Medicine, Chung Shan Medical University, Taichung, Taiwan.
authors: Teng-Yu
authors: TY
authors: Lee
authors: Division of Gastroenterology and Hepatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; Department of Medicine, Chung Shan Medical University, Taichung, Taiwan.
authors: Chi-Sen
authors: CS
authors: Chang
authors: Division of Gastroenterology and Hepatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; Department of Internal Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan.
authors: Hong-Zen
authors: HZ
authors: Yeh
keywords: Dyspepsia; Functional dyspepsia; Helicobacter pylori