title: COMPULS: design of a multicenter phenotypic, cognitive, genetic, and magnetic resonance imaging study in children with compulsive syndromes.
abstract: Compulsivity, the closely linked trait impulsivity and addictive behaviour are associated with several neurodevelopmental disorders, including attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and obsessive compulsive disorder (OCD). All three disorders show impaired fronto-striatal functioning, which may be related to altered glutamatergic signalling. Genetic factors are also thought to play an important role in the aetiology of compulsivity-related disorders.
  
  
  
  The COMPULS study is a multi-center study designed to investigate the relationship between the traits compulsivity, impulsivity, and, to a lesser extent, addictive behaviour within and across the neurodevelopmental disorders ADHD, ASD, and OCD. This will be done at the phenotypic, cognitive, neural, and genetic level. In total, 240 participants will take part in COMPULS across four different sites in Europe. Data collection will include diagnostic interviews, behavioural questionnaires, cognitive measures, structural, functional and spectral neuroimaging, and genome-wide genetic information.
  
  
  
  The COMPULS study will offer the unique opportunity to investigate several key aspects of compulsivity across a large cohort of ADHD, ASD and OCD patients.
authors: Department of Cognitive Neuroscience, Donders Institute of Brain, Cognition and Behaviour, Radboud University Medical Center, Geert Grooteplein Noord 10 (Huispost 126), 6525, EZ, Nijmegen, The Netherlands. j.naaijen@donders.ru.nl.
authors: Jilly
authors: J
authors: Naaijen
authors: Karakter child and adolescent psychiatry university center, Nijmegen, The Netherlands.
authors: Saskia
authors: S
authors: de Ruiter
authors: Department of Cognitive Neuroscience, Donders Institute of Brain, Cognition and Behaviour, Radboud University Medical Center, Geert Grooteplein Noord 10 (Huispost 126), 6525, EZ, Nijmegen, The Netherlands.
authors: Marcel P
authors: MP
authors: Zwiers
authors: Department of Cognitive Neuroscience, Donders Institute of Brain, Cognition and Behaviour, Radboud University Medical Center, Geert Grooteplein Noord 10 (Huispost 126), 6525, EZ, Nijmegen, The Netherlands.
authors: Jeffrey C
authors: JC
authors: Glennon
authors: NICHE lab, department of psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
authors: Sarah
authors: S
authors: Durston
authors: Department of Neuroimaging, King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK.
authors: David J
authors: DJ
authors: Lythgoe
authors: Department of Neuroimaging, King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK.
authors: Steven C R
authors: SC
authors: Williams
authors: Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty, Mannheim/Heidelberg University, Mannheim, Germany.
authors: Tobias
authors: T
authors: Banaschewski
authors: Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty, Mannheim/Heidelberg University, Mannheim, Germany.|Department of Child and Adolescent Psychiatry, University of Zurich, Zurich, Switzerland.|Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland.|Neuroscience Center Zurich, University of Zurich and ETH Zurich, Zurich, Switzerland.
authors: Daniel
authors: D
authors: Brandeis
authors: Departments of Human Genetics and Psychiatry, Donders Institute of Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.
authors: Barbara
authors: B
authors: Franke
authors: Department of Cognitive Neuroscience, Donders Institute of Brain, Cognition and Behaviour, Radboud University Medical Center, Geert Grooteplein Noord 10 (Huispost 126), 6525, EZ, Nijmegen, The Netherlands.|Karakter child and adolescent psychiatry university center, Nijmegen, The Netherlands.
authors: Jan K
authors: JK
authors: Buitelaar
mesh_terms: D001289:Attention Deficit Disorder with Hyperactivity / Q000175:diagnosis* / Q000523:psychology; D000067877:Autism Spectrum Disorder / Q000175:diagnosis* / Q000523:psychology; D001921:Brain / Q000000981:diagnostic imaging; D002648:Child; D002652:Child Behavior / Q000523:psychology; D003071:Cognition; D003192:Compulsive Behavior / Q000175:diagnosis* / Q000523:psychology; D005060:Europe; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology*; D006801:Humans; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D059906:Neuroimaging / Q000379:methods; D009771:Obsessive-Compulsive Disorder / Q000175:diagnosis* / Q000523:psychology; D010641:Phenotype; D011446:Prospective Studies; D011795:Surveys and Questionnaires; D013577:Syndrome
keywords: ADHD; ASD; Compulsivity; Fronto-striatal circuit; Glutamate; OCD