title: Membrane Trafficking: An Endosome Tether Meets a Rab and Collapses.
abstract: Long-range tethering is a ubiquitous recognition event preceding membrane fusion. A new study shows that Rab GTPase binding causes 'entropic collapse' of the coiled-coil endosome tether EEA1, driving membrane apposition and facilitating short-range interactions required for fusion.
authors: Program in Molecular Medicine and Department of Biochemistry & Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA.
authors: Sanchaita
authors: S
authors: Das
authors: Program in Molecular Medicine and Department of Biochemistry & Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address: David.Lambright@umassmed.edu.
authors: David G
authors: DG
authors: Lambright
mesh_terms: D011992:Endosomes; D008561:Membrane Fusion; D011485:Protein Binding; D021381:Protein Transport