title: Extracellular Microvesicles (ExMVs) in Cell to Cell Communication: A Role of Telocytes.
abstract: There are several mechanisms by which cells communicate with each other. Evidence accumulates that the evolutionary oldest mechanisms of cell-cell communication involves extracellular microvesicles (ExMVs). Generally, these circular membrane fragments enriched for mRNA, miRNA, proteins, and bioactive lipids are released by exocytosis from endosomal compartment or are directly formed by budding from cell surface membranes. ExMVs from endosomal compartment called exosomes are smaller in size ~100 nM as compared to larger ones released from cell membranes that are in size up to 1 μM. In this chapter we will present an emerging link between ExMVs and recently identified novel cell-cell communication network involving a new type of cell known as telocyte. Mounting evidence accumulates that telocytes mediate several of their biological effects in several organs by releasing ExMVs enriched in mRNA, miRNA, proteins, and several biological mediators to the target cells.
authors: Stem Cell Institute at James Graham Brown Cancer Center, University of Louisville, 500 S. Floyd Street, Rm. 107, Louisville, KY, 40202, USA. mzrata01@louisville.edu.
authors: Mariusz Z
authors: MZ
authors: Ratajczak
authors: Stem Cell Institute at James Graham Brown Cancer Center, University of Louisville, 500 S. Floyd Street, Rm. 107, Louisville, KY, 40202, USA.
authors: Daniel
authors: D
authors: Ratajczak
authors: Stem Cell Institute at James Graham Brown Cancer Center, University of Louisville, 500 S. Floyd Street, Rm. 107, Louisville, KY, 40202, USA.
authors: Daniel
authors: D
authors: Pedziwiatr
mesh_terms: D000818:Animals; D002450:Cell Communication / Q000235:genetics*; D002454:Cell Differentiation; D002462:Cell Membrane / Q000378:metabolism* / Q000648:ultrastructure; D000067128:Extracellular Vesicles / Q000378:metabolism* / Q000648:ultrastructure; D005786:Gene Expression Regulation; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000378:metabolism* / Q000648:ultrastructure; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism; D010316:Particle Size; D011506:Proteins / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D000067170:Telocytes / Q000378:metabolism* / Q000648:ultrastructure
chemical_list: D035683:MicroRNAs; D011506:Proteins; D012333:RNA, Messenger
keywords: Cell-cell communication; Ectosomes; Exosomes; Extracellular microvesicles (ExMVs); Horizontal transfer of mRNA; Membrane lipid rafts; Multivesicular cargo; Telocytes