title: Urinary l-type fatty acid-binding protein is a predictor of early renal function after partial nephrectomy.
abstract: OBJECTIVE
  Urinary biomarkers of renal injury urinary may identify loss of renal function following nephron-sparing surgery (NSS). This study was designed to evaluate whether urinary l-type fatty acid-binding protein (l-FABP) is an early biomarker of loss of renal function after NSS. Specifically, the kinetics of urinary l-FABP level after NSS and its correlation with factors related to ischemic renal injury were analyzed.
  
  
  METHODS
  This study prospectively evaluated 18 patients who underwent NSS between July and December 2014, including 12 who underwent laparoscopic and six who underwent robot-assisted partial nephrectomy. Urinary l-FABP concentrations were measured preoperatively and 1, 2, 3, 6, 12, 24, 48, and 72 h after renal artery declamping. Loss of renal function loss was calculated by comparing the effective renal plasma flow, as determined by99mTc-mercaptoacetyltriglycine (MAG3) clearance, on the operated and normal sides. The decrease in estimated glomerular filtration rate from before surgery to six months after surgery was also measured.
  
  
  RESULTS
  Urinary l-FABP concentration peaked within 2 h of declamping, which may quantify nephron damage caused by ischemia. The decrease in MAG3 reduction ratio correlated with both the ischemia time and peak urinary l-FABP concentration. Peak urinary l-FABP concentration showed a significant correlation with MAG3 reduction ratio.
  
  
  CONCLUSIONS
  l-FABP is a suitable urinary biomarker for predicting the extent of ischemic renal injury.
authors: a Department of Urology and Andrology, Graduate School of Medicine , Kansai Medical University , Osaka , Japan.
authors: Masaaki
authors: M
authors: Yanishi
authors: a Department of Urology and Andrology, Graduate School of Medicine , Kansai Medical University , Osaka , Japan.
authors: Hidefumi
authors: H
authors: Kinoshita
authors: a Department of Urology and Andrology, Graduate School of Medicine , Kansai Medical University , Osaka , Japan.
authors: Takao
authors: T
authors: Mishima
authors: a Department of Urology and Andrology, Graduate School of Medicine , Kansai Medical University , Osaka , Japan.
authors: Hisanori
authors: H
authors: Taniguchi
authors: a Department of Urology and Andrology, Graduate School of Medicine , Kansai Medical University , Osaka , Japan.
authors: Kenji
authors: K
authors: Yoshida
authors: a Department of Urology and Andrology, Graduate School of Medicine , Kansai Medical University , Osaka , Japan.
authors: Yoshihiro
authors: Y
authors: Komai
authors: a Department of Urology and Andrology, Graduate School of Medicine , Kansai Medical University , Osaka , Japan.
authors: Kaneki
authors: K
authors: Yasuda
authors: a Department of Urology and Andrology, Graduate School of Medicine , Kansai Medical University , Osaka , Japan.
authors: Masato
authors: M
authors: Watanabe
authors: a Department of Urology and Andrology, Graduate School of Medicine , Kansai Medical University , Osaka , Japan.
authors: Motohiko
authors: M
authors: Sugi
authors: a Department of Urology and Andrology, Graduate School of Medicine , Kansai Medical University , Osaka , Japan.
authors: Tadashi
authors: T
authors: Matsuda
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000652:urine; D050556:Fatty Acid-Binding Proteins / Q000652:urine*; D005260:Female; D006801:Humans; D007511:Ischemia / Q000503:physiopathology*; D007564:Japan; D007677:Kidney Function Tests; D010535:Laparoscopy / Q000009:adverse effects*; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy / Q000009:adverse effects*; D009399:Nephrons / Q000293:injuries*; D011446:Prospective Studies; D012077:Renal Artery / Q000503:physiopathology*; D013997:Time Factors
chemical_list: D015415:Biomarkers; D050556:Fatty Acid-Binding Proteins
keywords: l-Type fatty acid-binding protein; partial nephrectomy; renal function; renal injury; urinary biomarker