title: Weight loss surgery in adolescents corrects high-density lipoprotein subspecies and their function.
abstract: Youth with obesity have an altered high-density lipoprotein (HDL) subspecies profile characterized by depletion of large apoE-rich HDL particles and an enrichment of small HDL particles. The goal of this study was to test the hypothesis that this atherogenic HDL profile is reversible and that HDL function would improve with metabolic surgery.
  
  
  
  Serum samples from adolescent males with severe obesity mean±s.d. age of 17.4±1.6 years were studied at baseline and 1 year following vertical sleeve gastrectomy (VSG). HDL subspecies and HDL function were evaluated pre and post VSG using paired t-tests. A lean group of adolescents was included as a reference group.
  
  
  
  After VSG, body mass index decreased by 32% and insulin resistance as estimated by homeostatic model assessment of insulin resistance decreased by 75% (both P<0.01). Large apoE-rich HDL subspecies increased following VSG (P<0.01) and approached that of lean adolescents despite participants with considerable residual obesity. In addition, HDL function improved compared with baseline (cholesterol efflux capacity increased by 12%, HDL lipid peroxidation potential decreased by 30% and HDL anti-oxidative capacity improved by 25%, all P<0.01).
  
  
  
  Metabolic surgery results in a significant improvement in the quantity of large HDL subspecies and HDL function. Our data suggest metabolic surgery may improve cardiovascular risk in adolescents and young adults.
authors: Center for Lipid and Arteriosclerosis Science, Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, OH, USA.
authors: W S
authors: WS
authors: Davidson
authors: Department of Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
authors: T H
authors: TH
authors: Inge
authors: Division of Endocrinology, Department of Pediatrics, Cincinnati Children's Hospital Research Foundation, Cincinnati, OH, USA.
authors: H
authors: H
authors: Sexmith
authors: Division of Endocrinology, Department of Pediatrics, Cincinnati Children's Hospital Research Foundation, Cincinnati, OH, USA.
authors: A
authors: A
authors: Heink
authors: Division of Endocrinology, Department of Pediatrics, Cincinnati Children's Hospital Research Foundation, Cincinnati, OH, USA.
authors: D
authors: D
authors: Elder
authors: Center for Lipid and Arteriosclerosis Science, Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, OH, USA.
authors: D Y
authors: DY
authors: Hui
authors: Center for Lipid and Arteriosclerosis Science, Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, OH, USA.
authors: J T
authors: JT
authors: Melchior
authors: David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
authors: T
authors: T
authors: Kelesidis
authors: Division of Endocrinology, Department of Pediatrics, Cincinnati Children's Hospital Research Foundation, Cincinnati, OH, USA.
authors: A S
authors: AS
authors: Shah
mesh_terms: D000293:Adolescent; D015391:Gastroplasty; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D008075:Lipoproteins, HDL / Q000097:blood*; D008297:Male; D009767:Obesity, Morbid / Q000378:metabolism / Q000601:surgery*; D009820:Ohio / Q000453:epidemiology; D063766:Pediatric Obesity / Q000378:metabolism / Q000601:surgery*; D011446:Prospective Studies; D016896:Treatment Outcome; D015431:Weight Loss / Q000502:physiology*; D055815:Young Adult
chemical_list: D008075:Lipoproteins, HDL