title: TcoF-DB v2: update of the database of human and mouse transcription co-factors and transcription factor interactions.
abstract: Transcription factors (TFs) play a pivotal role in transcriptional regulation, making them crucial for cell survival and important biological functions. For the regulation of transcription, interactions of different regulatory proteins known as transcription co-factors (TcoFs) and TFs are essential in forming necessary protein complexes. Although TcoFs themselves do not bind DNA directly, their influence on transcriptional regulation and initiation, although indirect, has been shown to be significant, with the functionality of TFs strongly influenced by the presence of TcoFs. In the TcoF-DB v2 database, we collect information on TcoFs. In this article, we describe updates and improvements implemented in TcoF-DB v2. TcoF-DB v2 provides several new features that enables exploration of the roles of TcoFs. The content of the database has significantly expanded, and is enriched with information from Gene Ontology, biological pathways, diseases and molecular signatures. TcoF-DB v2 now includes many more TFs; has substantially increased the number of human TcoFs to 958, and now includes information on mouse (418 new TcoFs). TcoF-DB v2 enables the exploration of information on TcoFs and allows investigations into their influence on transcriptional regulation in humans and mice. TcoF-DB v2 can be accessed at http://tcofdb.org/.
authors: Massey University Auckland, Institute of Natural and Mathematical Sciences, Auckland, New Zealand.
authors: Sebastian
authors: 0000-0002-3947-8226
authors: S
authors: Schmeier
authors: King Abdullah University of Science and Technology (KAUST), Computational Bioscience Research Center (CBRC), Thuwal, Kingdom of Saudi Arabia.
authors: Tanvir
authors: T
authors: Alam
authors: King Abdullah University of Science and Technology (KAUST), Computational Bioscience Research Center (CBRC), Thuwal, Kingdom of Saudi Arabia.
authors: Magbubah
authors: M
authors: Essack
authors: King Abdullah University of Science and Technology (KAUST), Computational Bioscience Research Center (CBRC), Thuwal, Kingdom of Saudi Arabia vladimir.bajic@kaust.edu.sa.
authors: Vladimir B
authors: 0000-0001-5435-4750
authors: VB
authors: Bajic
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism; D030541:Databases, Genetic; D005786:Gene Expression Regulation; D006801:Humans; D051379:Mice; D011485:Protein Binding; D014157:Transcription Factors / Q000378:metabolism
chemical_list: D002352:Carrier Proteins; D014157:Transcription Factors