title: Nuclear envelope rupture drives genome instability in cancer.
abstract: The nuclear envelope, composed of two lipid bilayers and numerous accessory proteins, has evolved to house the genetic material of all eukaryotic cells. In so doing, the nuclear envelope provides a physical barrier between chromosomes and the cytoplasm. Once believed to be highly stable, recent studies demonstrate that the nuclear envelope is prone to rupture. These rupture events expose chromosomal DNA to the cytoplasmic environment and have the capacity to promote DNA damage. Thus nuclear rupture may be an unappreciated mechanism of mutagenesis.
authors: Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA 02118.
authors: Sanghee
authors: S
authors: Lim
authors: Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA 02118.
authors: Ryan J
authors: RJ
authors: Quinton
authors: Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA 02118 nganem@bu.edu.|Department of Medicine, Division of Hematology and Oncology, Boston University School of Medicine, Boston, MA 02118.
authors: Neil J
authors: NJ
authors: Ganem
mesh_terms: D002467:Cell Nucleus / Q000378:metabolism / Q000502:physiology; D002875:Chromosomes / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D004249:DNA Damage / Q000502:physiology; D005057:Eukaryotic Cells / Q000378:metabolism; D042822:Genomic Instability / Q000235:genetics; D009369:Neoplasms / Q000235:genetics; D009685:Nuclear Envelope / Q000378:metabolism* / Q000502:physiology*; D009687:Nuclear Proteins / Q000378:metabolism
chemical_list: D009687:Nuclear Proteins