title: Human Endothelial Cell Models in Biomaterial Research.
abstract: Endothelial cell (EC) models have evolved as important tools in biomaterial research due to ubiquitously occurring interactions between implanted materials and the endothelium. However, screening the available literature has revealed a gap between material scientists and physiologists in terms of their understanding of these biomaterial-endothelium interactions and their relative importance. Consequently, EC models are often applied in nonphysiological experimental setups, or too extensive conclusions are drawn from their results. The question arises whether this might be one reason why, among the many potential biomaterials, only a few have found their way into the clinic. In this review, we provide an overview of established EC models and possible selection criteria to enable researchers to determine the most reliable and relevant EC model to use.
authors: Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Department Radiopharmaceutical and Chemical Biology, Dresden, Germany.
authors: Sandra
authors: S
authors: Hauser
authors: Institute of Biomaterial Science and Berlin-Brandenburg Centre for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany; Helmholtz Virtual Institute 'Multifunctional Biomaterials for Medicine', Teltow, Germany.
authors: Friedrich
authors: F
authors: Jung
authors: Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Department Radiopharmaceutical and Chemical Biology, Dresden, Germany; Technische Universität Dresden, Department of Chemistry and Food Chemistry, Dresden, Germany. Electronic address: j.pietzsch@hzdr.de.
authors: Jens
authors: J
authors: Pietzsch
mesh_terms: D001672:Biocompatible Materials; D035843:Biomedical Research / Q000379:methods*; D042783:Endothelial Cells; D006801:Humans; D008954:Models, Biological
chemical_list: D001672:Biocompatible Materials
keywords: bone regeneration; endothelial cell heterogeneity; soft tissue regeneration; stents; vascular grafts