title: The Microbiome.
abstract: The microbiome is increasingly recognized as a critical component in human development, health, and disease. Its relevance to toxicology and pharmacology involves challenges to current concepts related to absorption, metabolism, gene:environment, and pathways of response. Framing testable hypotheses for experimental and epidemiological studies will require attention to study designs, biosampling, data analysis, and attention to confounders.
authors: 1 Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.
authors: Ellen K
authors: EK
authors: Silbergeld
mesh_terms: D000818:Animals; D059647:Gene-Environment Interaction; D006801:Humans; D055432:Metabolomics; D056186:Metagenomics; D064307:Microbiota / Q000187:drug effects / Q000235:genetics / Q000502:physiology*; D010600:Pharmacology / Q000379:methods*; D012107:Research Design; D014116:Toxicology / Q000379:methods*; D015262:Xenobiotics / Q000493:pharmacokinetics / Q000494:pharmacology / Q000633:toxicity
chemical_list: D015262:Xenobiotics
keywords: epidemiology; metabolomics; metagenomics; microbiome; pharmacology; toxicology