title: Effect of Change in Portal Vein Flow Rates on Hepatic Ablations Created with a Bipolar Radiofrequency Ablation Device.
abstract: Purpose To investigate the effect of change in portal vein flow rates on the size and shape of ablations created by a bipolar radiofrequency (RF) ablation device. Materials and Methods This study was exempt from institutional animal care and use committee review. An in vitro bovine liver model perfused with autologous blood via the portal vein at three flow rates (60, 80, 100 mL/min per 100 g of liver) was used. Four ablations, two bipolar and two monopolar (control probe), were made in each of five livers perfused at each flow rate. Short- and long-axis diameters were measured from gross specimens, and volume and sphericity index were calculated for each ablation. A general linear mixed model accounting for correlation within the liver was used to evaluate the effects of flow on ablations. Analyses were performed by using software. Results There was no significant difference in the size or shape of ablations created by the bipolar device at the different flow rates (P > .05 for all outcomes). The monopolar device demonstrated the expected inverse association between ablation size and change in flow (P < .01 for all outcomes). The mean ± standard deviation of short-axis diameter, long-axis diameter, volume, and sphericity index of the bipolar ablations was 4.3 cm ± 0.1, 4.2 cm ± 0.1, 41.0 cm3± 1.8, and 1.1 ± 0.1, respectively. Conclusion Unlike monopolar RF ablation, change in portal vein flow rates does not have a statistically significant effect on the size or shape of ablations created by the bipolar RF ablation device tested.©RSNA, 2016.
authors: From the Department of Radiology, School of Medicine, University of Colorado, Mail Stop L954, 12401 E 17th Ave, PO Box 6510, Aurora, CO 80045.
authors: Gerald D
authors: GD
authors: Dodd
authors: From the Department of Radiology, School of Medicine, University of Colorado, Mail Stop L954, 12401 E 17th Ave, PO Box 6510, Aurora, CO 80045.
authors: Anthony C
authors: AC
authors: Lanctot
authors: From the Department of Radiology, School of Medicine, University of Colorado, Mail Stop L954, 12401 E 17th Ave, PO Box 6510, Aurora, CO 80045.
authors: Kimberly E
authors: KE
authors: Lind
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity / Q000502:physiology*; D017115:Catheter Ablation / Q000295:instrumentation* / Q000379:methods; D002417:Cattle; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005260:Female; D006498:Hepatectomy / Q000295:instrumentation* / Q000379:methods; D066298:In Vitro Techniques; D008099:Liver / Q000098:blood supply / Q000502:physiology* / Q000601:surgery*; D008102:Liver Circulation; D011169:Portal Vein / Q000502:physiology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D016896:Treatment Outcome