title: Topographic profile of choroid in eyes after acute primary angle-closure.
abstract: OBJECTIVE
  To characterize and compare the topographic profile of choroid in eyes after acute primary angle-closure (APAC) and in normal controls.
  
  
  METHODS
  A prospective observational study was conducted. Forty-four consecutive patients who had experienced unilateral APAC that was resolved by treatment were recruited. Seventy age- and sex-matched normal individuals were recruited as controls.
  
  
  METHODS
  Enhanced depth imaging-optical coherence tomography was used to measure choroidal thickness (CT) in 9 diffuse locations of macular region. The average CT was compared among each location in the APAC and control groups and between the same locations in the 2 groups.
  
  
  RESULTS
  Variants of CT at different macular locations were found in both groups; it was greatest at subfoveal locations and spread thinner around them, to reach a significant decrease (all p ≤ 0.05) 3 mm away in all directions from the fovea except for the superior direction in normal controls (p = 0.472). Among the 4 directions, the superior had the thickest CT in both groups, followed by the temporal, inferior, and nasal directions in both groups, whereas the APAC had a thicker choroid profile at each location (all p < 0.05). Univariate analysis showed that age, sex, anterior chamber depth, axial length, and spherical equivalent were all associated with the subfoveal choroidal thickness (SFCT) (all p < 0.1). Multivariable linear regression analysis showed that the SFCT was significantly thicker in association with an APAC diagnosis, shorter axial length, greater spherical equivalent refractive error, and younger female subjects (all p ≤ 0.05).
  
  
  CONCLUSIONS
  APAC eyes have a thicker choroid than normal eyes in the macular region, and the increase in CT in APAC eyes follows topographic distribution as in normal control eyes.
authors: Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-Sen University, Guangzhou, People's Republic of China.
authors: Xinbo
authors: X
authors: Gao
authors: Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-Sen University, Guangzhou, People's Republic of China.
authors: Wenbin
authors: W
authors: Huang
authors: Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-Sen University, Guangzhou, People's Republic of China.
authors: Wei
authors: W
authors: Wang
authors: Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-Sen University, Guangzhou, People's Republic of China.
authors: Minwen
authors: M
authors: Zhou
authors: Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-Sen University, Guangzhou, People's Republic of China.
authors: Jiawei
authors: J
authors: Wang
authors: Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-Sen University, Guangzhou, People's Republic of China.
authors: Shaolin
authors: S
authors: Du
authors: Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-Sen University, Guangzhou, People's Republic of China.
authors: Shida
authors: S
authors: Chen
authors: Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-Sen University, Guangzhou, People's Republic of China. Electronic address: zhangxl2@mail.sysu.edu.cn.
authors: Xiulan
authors: X
authors: Zhang
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D002829:Choroid / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D015812:Glaucoma, Angle-Closure / Q000175:diagnosis / Q000503:physiopathology*; D006068:Gonioscopy; D064368:Healthy Volunteers; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology; D008297:Male; D033401:Microscopy, Acoustic; D008875:Middle Aged; D011446:Prospective Studies; D041623:Tomography, Optical Coherence; D019371:Topography, Medical; D014792:Visual Acuity / Q000502:physiology