title: Effectiveness of cognitive-coping therapy and alteration of resting-state brain function in obsessive-compulsive disorder.
abstract: Cognitive-coping therapy (CCT), integrating cognitive theory with stress-coping theory, is an efficacious therapy for obsessive-compulsive disorder (OCD). However, the potential brain mediation for the effectiveness remains unclear. We sought to investigate differences of resting-state brain function between OCD and healthy controls and if such differences would be changed by a four-week CCT.
  
  
  
  Thirty-one OCD patients were recruited and randomized into CCT (n=15) and pharmacotherapy plus CCT (pCCT, n=16) groups, together with 25 age-, gender- and education-matched healthy controls. The Yale-Brown Obsessive Compulsive Scale (Y-BOCS) was scored to evaluate the severity in symptoms. Resting-state functional magnetic resonance imaging was scanned pre- and post-treatment.
  
  
  
  For patients, Y-BOCS scores were reduced during four-week treatment for CCT and pCCT (P<0.001), but no group difference was observed. No differences in amplitude of low-frequency fluctuation (ALFF) values were found between CCT and pCCT either pre- or post-treatment. Compared to controls, ALFF in OCD patients was higher in the left hippocampus, parahippocampus, and temporal lobes, but lower in the right orbitofrontal cortex, rectus, bilateral calcarine, cuneus, lingual, occipital, left parietal, postcentral, precentral, and parietal (corrected P<0.05). The ALFF in those regions was not significantly correlated to the severity of OCD symptoms. After a 4-week treatment, the ALFF differences between OCD patients and controls disappeared.
  
  
  
  The pharmacotherapy group was not included since OCD patients generally do not respond to pharmacotherapy in four weeks.
  
  
  
  Our data indicated that resting-state brain function was different between OCD and controls; such differences disappeared after OCD symptoms were relieved.
authors: The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang Medical University, Xinxiang City 453002, Henan Province, PR China.
authors: Hong-Zeng
authors: HZ
authors: Zhao
authors: The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang Medical University, Xinxiang City 453002, Henan Province, PR China.
authors: Chang-Hong
authors: CH
authors: Wang
authors: Hangzhou Institute of Service Engineering, Hangzhou Normal University, Hangzhou, Zhejiang, PR China; Center for Cognition and Brain Disorders, Affiliated Hospital, Hangzhou Normal University, Hangzhou 310015, Zhejiang, PR China; Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou, Zhejiang, PR China.
authors: Zhong-Zhan
authors: ZZ
authors: Gao
authors: The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang Medical University, Xinxiang City 453002, Henan Province, PR China.
authors: Jian-Dong
authors: JD
authors: Ma
authors: The Fifth People Hospital of Kaifeng, Kaifeng City 475003, Henan Province, PR China.
authors: Ping
authors: P
authors: Huang
authors: The First Affiliated Hospital of Zhengzhou University, Zhengzhou City 450052, Henan Province, PR China.
authors: Heng-Fen
authors: HF
authors: Li
authors: The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang Medical University, Xinxiang City 453002, Henan Province, PR China.
authors: De-En
authors: DE
authors: Sang
authors: The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang Medical University, Xinxiang City 453002, Henan Province, PR China.
authors: Xiao-Wen
authors: XW
authors: Shan
authors: The Fifth People Hospital of Kaifeng, Kaifeng City 475003, Henan Province, PR China; Workstation of Henan Province for Psychiatry Experts, Kaifeng City 475003, Henan Province, PR China.
authors: Shao-Jie
authors: SJ
authors: Kou
authors: The Fifth People Hospital of Kaifeng, Kaifeng City 475003, Henan Province, PR China.
authors: Zhi-Rong
authors: ZR
authors: Li
authors: The Medical Group of Zhengzhou First People's Hospital, Zhengzhou City, Henan Province, PR China.
authors: Li
authors: L
authors: Ma
authors: The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang Medical University, Xinxiang City 453002, Henan Province, PR China.
authors: Zhao-Hui
authors: ZH
authors: Zhang
authors: The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang Medical University, Xinxiang City 453002, Henan Province, PR China.
authors: Jian-Hong
authors: JH
authors: Zhang
authors: The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang Medical University, Xinxiang City 453002, Henan Province, PR China.
authors: Hua
authors: H
authors: Ouyang
authors: The Medical Group of Zhengzhou First People's Hospital, Zhengzhou City, Henan Province, PR China.
authors: Hong-Kai
authors: HK
authors: Lian
authors: Center for Cognition and Brain Disorders, Affiliated Hospital, Hangzhou Normal University, Hangzhou 310015, Zhejiang, PR China; Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou, Zhejiang, PR China.
authors: Yu-Feng
authors: YF
authors: Zang
authors: The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang Medical University, Xinxiang City 453002, Henan Province, PR China; Workstation of Henan Province for Psychiatry Experts, Kaifeng City 475003, Henan Province, PR China. Electronic address: huxianzhang@yahoo.com.
authors: Xian-Zhang
authors: XZ
authors: Hu
mesh_terms: D000223:Adaptation, Psychological; D000328:Adult; D001921:Brain / Q000503:physiopathology*; D015928:Cognitive Behavioral Therapy; D003131:Combined Modality Therapy; D005260:Female; D059907:Functional Neuroimaging; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000188:drug therapy / Q000503:physiopathology* / Q000628:therapy*; D055815:Young Adult
keywords: Cognitive-coping therapy; Obsessive-compulsive disorder; Resting-state fMRI; Treatment