title: Interleukin 32: a novel player in the control of infectious diseases.
abstract: Interleukin 32 (IL-32) is a proinflammatory cytokine, expressed as 9 distinct isoforms. The most active isoform is the predominantly intracellular-functioning IL-32γ. Involvement of IL-32 in infectious diseases is increasingly being appreciated. Production of IL-32 promotes pathways that serve to control bacterial infection, especially those caused by mycobacteria. A similar role for this cytokine is observed in the cellular response to viral infections. In addition to its protective effects against microorganisms, IL-32 is involved in immunopathogenesis of some infectious diseases. In parasitic diseases, it has been demonstrated that this cytokine is induced by Leishmania infection. In this review, we summarize the present data on the role of IL-32 in infectious diseases, highlighting this cytokine as new target for control of infections.
authors: Instituto de Patologia Tropical e Saúde Pública, Universidade Federal Goiás, Goiânia, Goiás, Brazil; and fatimardias@gmail.com.
authors: Fátima
authors: F
authors: Ribeiro-Dias
authors: Instituto de Patologia Tropical e Saúde Pública, Universidade Federal Goiás, Goiânia, Goiás, Brazil; and.
authors: Rodrigo
authors: R
authors: Saar Gomes
authors: Instituto de Patologia Tropical e Saúde Pública, Universidade Federal Goiás, Goiânia, Goiás, Brazil; and.
authors: Lucas Luiz
authors: LL
authors: de Lima Silva
authors: Instituto de Patologia Tropical e Saúde Pública, Universidade Federal Goiás, Goiânia, Goiás, Brazil; and.|Department of Internal Medicine and Radboud Center of Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, The Netherlands.
authors: Jéssica Cristina
authors: JC
authors: Dos Santos
authors: Department of Internal Medicine and Radboud Center of Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, The Netherlands leo.joosten@radboudumc.nl.
authors: Leo A B
authors: LA
authors: Joosten
mesh_terms: D000818:Animals; D001424:Bacterial Infections / Q000378:metabolism; D003141:Communicable Diseases / Q000378:metabolism*; D006801:Humans; D007378:Interleukins / Q000378:metabolism*; D008954:Models, Biological; D015398:Signal Transduction; D014777:Virus Diseases / Q000378:metabolism
chemical_list: D007378:Interleukins
keywords: bacteria; cytokines; viruses