title: Lipid droplet hijacking by intracellular pathogens.
abstract: Lipid droplets were long considered to be simple storage structures, but they have recently been shown to be dynamic organelles involved in diverse biological processes, including emerging roles in innate immunity. Various intracellular pathogens, including viruses, bacteria, and parasites, specifically target host lipid droplets during their life cycle. Viruses such as hepatitis C, dengue, and rotaviruses use lipid droplets as platforms for assembly. Bacteria, such as mycobacteria and Chlamydia, and parasites, such as trypanosomes, use host lipid droplets for nutritional purposes. The possible use of lipid droplets by intracellular pathogens, as part of an anti-immunity strategy, is an intriguing question meriting further investigation in the near future.
authors: INSERM U966 and IBiSA Electron Microscopy Facility, François Rabelais University and CHRU de Tours, Tours, France.
authors: Philippe
authors: P
authors: Roingeard
authors: Laboratory of Cell Biology, Institute of Biological Sciences, Federal University of Juiz de Fora-UFJF, Juiz de Fora, Minas Gerais, Brazil.
authors: Rossana C N
authors: RC
authors: Melo
mesh_terms: D000818:Animals; D001419:Bacteria / Q000378:metabolism*; D006801:Humans; D066292:Lipid Droplets / Q000276:immunology* / Q000382:microbiology / Q000469:parasitology / Q000821:virology; D050356:Lipid Metabolism; D014345:Trypanosoma / Q000378:metabolism*; D019065:Virus Assembly
keywords: bacteria; innate immunity; lipid droplet; microbial-cell interaction; parasites; viruses