title: Scanning of selection signature provides a glimpse into important economic traits in goats (Capra hircus).
abstract: Goats (Capra hircus) are one of the oldest livestock domesticated species, and have been used for their milk, meat, hair and skins over much of the world. Detection of selection footprints in genomic regions can provide potential insights for understanding the genetic mechanism of specific phenotypic traits and better guide in animal breeding. The study presented here has generated 192.747G raw data and identified more than 5.03 million single-nucleotide polymorphisms (SNPs) and 334,151 Indels (insertions and deletions). In addition, we identified 155 and 294 candidate regions harboring 86 and 97 genes based on allele frequency differences in Dazu black goats (DBG) and Inner Mongolia cashmere goats (IMCG), respectively. Populations differentiation reflected by Fst values detected 368 putative selective sweep regions including 164 genes. The top 1% regions of both low heterozygosity and high genetic differentiation contained 239 (135 genes) and 176 (106 genes) candidate regions in DBG and IMCG, respectively. These genes were related to reproductive and productive traits, such as "neurohypophyseal hormone activity" and "adipocytokine signaling pathway". These findings may be conducive to molecular breeding and the long-term preservation of the valuable genetic resources for this species.
authors: College of Animal Science and Technology, Southwest University; Chongqing Key Laboratory of Forage &Herbivore; Chongqing Engineering Research Center for Herbivores Resource Protection and Utilization, Chongqing 400715, P. R. China.
authors: Dailu
authors: D
authors: Guan
authors: College of Animal Science and Technology, Southwest University; Chongqing Key Laboratory of Forage &Herbivore; Chongqing Engineering Research Center for Herbivores Resource Protection and Utilization, Chongqing 400715, P. R. China.
authors: Nanjian
authors: N
authors: Luo
authors: College of Animal Science and Technology, Southwest University; Chongqing Key Laboratory of Forage &Herbivore; Chongqing Engineering Research Center for Herbivores Resource Protection and Utilization, Chongqing 400715, P. R. China.
authors: Xiaoshan
authors: X
authors: Tan
authors: College of Animal Science and Technology, Southwest University; Chongqing Key Laboratory of Forage &Herbivore; Chongqing Engineering Research Center for Herbivores Resource Protection and Utilization, Chongqing 400715, P. R. China.
authors: Zhongquan
authors: Z
authors: Zhao
authors: College of Animal Science and Technology, Southwest University; Chongqing Key Laboratory of Forage &Herbivore; Chongqing Engineering Research Center for Herbivores Resource Protection and Utilization, Chongqing 400715, P. R. China.
authors: Yongfu
authors: Y
authors: Huang
authors: College of Animal Science and Technology, Southwest University; Chongqing Key Laboratory of Forage &Herbivore; Chongqing Engineering Research Center for Herbivores Resource Protection and Utilization, Chongqing 400715, P. R. China.
authors: Risu
authors: R
authors: Na
authors: College of Animal Science and Technology, Southwest University; Chongqing Key Laboratory of Forage &Herbivore; Chongqing Engineering Research Center for Herbivores Resource Protection and Utilization, Chongqing 400715, P. R. China.
authors: Jiahua
authors: J
authors: Zhang
authors: College of Animal Science and Technology, Southwest University; Chongqing Key Laboratory of Forage &Herbivore; Chongqing Engineering Research Center for Herbivores Resource Protection and Utilization, Chongqing 400715, P. R. China.
authors: Yongju
authors: Y
authors: Zhao
mesh_terms: D000818:Animals; D005787:Gene Frequency; D006041:Goats / Q000145:classification* / Q000235:genetics*; D059014:High-Throughput Nucleotide Sequencing; D054643:INDEL Mutation; D010802:Phylogeny; D020641:Polymorphism, Single Nucleotide; D040641:Quantitative Trait Loci; D012641:Selection, Genetic; D017422:Sequence Analysis, DNA