title: Jie-du granule preparation for the treatment of advanced hepatocellular carcinoma: a retrospective cohort study of 177 patients.
abstract: OBJECTIVE
  To compare the clinical efficacy of Jie-du granule preparation versus best supportive treatment in patients with advanced hepatocellular carcinoma.
  
  
  METHODS
  A retrospective cohort study was carried out in patients with advanced liver cancer. Patients were divided into Jie-du granule treatment (JD) and best supportive treatment (BST) groups. The main outcomes included median overall survival time.
  
  
  RESULTS
  A total of 177 patients with Barcelona Clinic Liver Cancer stage C receiving JD granule treatment or BST were enrolled between January 2012 and December 2014. The overall median survival time was 6.2 months (95% confidence interval [CI] 4.546-7.854) in the JD group versus 4 months (95% CI 3.471-4.529) in the BST group. Significant independent risk factors were alpha-fetoprotein (P = 0.048), Child-Pugh class (P = 0.005), vascular invasion (P = 0.003), and extrahepatic metastasis (P = 0.0018). For patients with two or fewer of these independent risk factors, the overall median survival of those treated with JD was significantly longer than that of patients receiving BST (P < 0.05).
  
  
  CONCLUSIONS
  Jie-du granule preparation may prolong survival of patients with advanced HCC.
authors: Department of Traditional Chinese Medicine, Changhai Hospital, Second Military Medical University, Shanghai, China.
authors: L Y
authors: LY
authors: Chen
authors: Department of Traditional Chinese Medicine, Changhai Hospital, Second Military Medical University, Shanghai, China.
authors: X F
authors: XF
authors: Zhai
authors: Department of Traditional Chinese Medicine, Changhai Hospital, Second Military Medical University, Shanghai, China.
authors: Z
authors: Z
authors: Chen
authors: Department of Liver Disease, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai, China.
authors: J F
authors: JF
authors: Zhu
authors: Department of Liver Disease, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai, China.
authors: P A
authors: PA
authors: Qian
authors: Department of Traditional Chinese Medicine, Changhai Hospital, Second Military Medical University, Shanghai, China.
authors: H T
authors: HT
authors: Zhao
authors: Department of Traditional Chinese Medicine, Changhai Hospital, Second Military Medical University, Shanghai, China.
authors: C Q
authors: CQ
authors: Ling
mesh_terms: D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology*; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology*; D008297:Male; D008516:Medicine, Chinese Traditional; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D016896:Treatment Outcome; D047368:Tumor Burden
chemical_list: D004365:Drugs, Chinese Herbal
keywords: Jie-du granule; best supportive treatment; hepatocellular carcinoma; retrospective cohort study