title: Focal Reduction in Cardiac123I-Metaiodobenzylguanidine Uptake in Patients With Anderson-Fabry Disease.
abstract: It remains to be elucidated whether cardiac sympathetic nervous activity is impaired in patients with Anderson-Fabry disease (AFD).
  
  
  
  We performed123I-meta-iodobenzylguanidine (MIBG) scintigraphy and gadolinium-enhanced cardiovascular magnetic resonance (CMR) in 5 AFD patients. MIBG uptake in the inferolateral wall, where wall thinning and delayed enhancement were noted on CMR, was significantly lower compared with the anteroseptal wall. The localized reduction in MIBG uptake was also noted in 2 patients with no obvious abnormal findings on CMR.
  
  
  
  Cardiac sympathetic nervous activity is impaired in AFD before development of structural myocardial abnormalities. (Circ J 2016; 80: 2550-2551).
authors: Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine.
authors: Saori
authors: S
authors: Yamamoto
authors: Hideaki
authors: H
authors: Suzuki
authors: Koichiro
authors: K
authors: Sugimura
authors: Shunsuke
authors: S
authors: Tatebe
authors: Tatsuo
authors: T
authors: Aoki
authors: Masanobu
authors: M
authors: Miura
authors: Nobuhiro
authors: N
authors: Yaoita
authors: Haruka
authors: H
authors: Sato
authors: Katuya
authors: K
authors: Kozu
authors: Hideki
authors: H
authors: Ota
authors: Kentaro
authors: K
authors: Takanami
authors: Kei
authors: K
authors: Takase
authors: Hiroaki
authors: H
authors: Shimokawa
mesh_terms: D019797:3-Iodobenzylguanidine / Q000008:administration & dosage / Q000493:pharmacokinetics; D000795:Fabry Disease / Q000000981:diagnostic imaging / Q000378:metabolism; D005260:Female; D005682:Gadolinium / Q000008:administration & dosage / Q000493:pharmacokinetics; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D011877:Radionuclide Imaging
chemical_list: D019797:3-Iodobenzylguanidine; D005682:Gadolinium