title: Interleukin-33 as a marker of disease activity in rheumatoid factor positive polyarticular juvenile idiopathic arthritis.
abstract: OBJECTIVE
  To investigate clinical usefulness of serum interleukin (IL)-33 levels as an indicator of disease activity in juvenile idiopathic arthritis (JIA).
  
  
  METHODS
  We measured serum levels of IL-33 in 39 patients with JIA, including 7 patients with rheumatoid factor positive poly-JIA (RF + poly-JIA), 8 patients with RF negative poly-JIA (RF-poly-JIA), 20 patients with oligoarticular JIA (Oligo-JIA), 4 patients with enthesitis-related arthritis (ERA) and 30 age-matched healthy controls. Furthermore, we determined their correlation with measures of disease activity.
  
  
  RESULTS
  Serum IL-33 levels in patients with RF + poly-JIA were significantly elevated compared to those in patients with RF-poly-JIA, oligo-JIA and HC. Serum IL-33 levels in patients with RF-poly-JIA, oligo-JIA and ERA were not elevated compared to those in HC. Serum IL-33 levels in RF + poly-JIA patients normalized in remission phase. Serum IL-33 levels correlated positively with RF in patients with RF + poly-JIA.
  
  
  CONCLUSIONS
  These results indicate that serum IL-33 levels in RF + poly-JIA patients correlated with disease activity, suggesting a potential role of IL-33 as a promising indicator of disease activity.
authors: a Department of Pediatrics , School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University , Kanazawa , Japan and.
authors: Sayaka
authors: S
authors: Ishikawa
authors: a Department of Pediatrics , School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University , Kanazawa , Japan and.
authors: Masaki
authors: M
authors: Shimizu
authors: a Department of Pediatrics , School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University , Kanazawa , Japan and.
authors: Natsumi
authors: N
authors: Inoue
authors: a Department of Pediatrics , School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University , Kanazawa , Japan and.|b Department of Pediatric Rheumatology , Hyogo Prefectural Kobe Children's Hospital , Kanazawa , Japan.
authors: Mao
authors: M
authors: Mizuta
authors: b Department of Pediatric Rheumatology , Hyogo Prefectural Kobe Children's Hospital , Kanazawa , Japan.
authors: Yasuo
authors: Y
authors: Nakagishi
authors: a Department of Pediatrics , School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University , Kanazawa , Japan and.
authors: Akihiro
authors: A
authors: Yachie
mesh_terms: D000293:Adolescent; D001171:Arthritis, Juvenile / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D002648:Child; D005260:Female; D006801:Humans; D000067596:Interleukin-33 / Q000097:blood*; D008297:Male; D012217:Rheumatoid Factor / Q000097:blood*
chemical_list: D015415:Biomarkers; C506536:IL33 protein, human; D000067596:Interleukin-33; D012217:Rheumatoid Factor
keywords: Interleukin-33; Rheumatoid factor positive polyarticular juvenile idiopathic arthritis