title: Biomarkers of exposure to environmental contaminants in French pregnant women from the Elfe cohort in 2011.
abstract: As part of the perinatal component of the French Human Biomonitoring (HBM) program, biomarkers levels of various chemicals have been described among pregnant women having given birth in continental France in 2011 and who have been enrolled in the Elfe cohort (French Longitudinal Study since Childhood). This paper describes the design of the study and provides main descriptive results regarding exposure biomarkers levels.
  
  
  
  Exposure biomarkers were measured in biological samples collected at delivery from pregnant women randomly selected among the participants in the clinical and biological component of the Elfe cohort (n=4145). The geometric mean and percentiles of the levels distribution were estimated for each biomarker. The sampling design was taken into account in order to obtain estimates representative of the French pregnant women in 2011.
  
  
  
  Results provide a nation-wide representative description of biomarker levels for important environmental contaminants among pregnant women who gave birth in France in 2011. Bisphenol A (BPA), and some metabolites of phthalates, pesticides (mainly pyrethroids), dioxins, furans, polychlorobiphenyls (PCBs), brominated flame retardants (BFRs), perfluorinated compounds (PFCs) and metals (except uranium) were quantified in almost 100% of the pregnant women. Some compounds showed a downward trend compared to previous studies (lead, mercury), but others did not (pyrethroids) and should be further monitored.
  
  
  
  The present results show that French pregnant women are exposed to a wide variety of pollutants, including some that have been banned or restricted in France.
authors: Direction of Environmental Health, Santé publique France, 12 rue du Val d'Osne, 94415 Saint Maurice Cedex, France. Electronic address: clementine.dereumeaux@santepubliquefrance.fr.
authors: Clémentine
authors: C
authors: Dereumeaux
authors: Direction of Environmental Health, Santé publique France, 12 rue du Val d'Osne, 94415 Saint Maurice Cedex, France.
authors: Abdesattar
authors: A
authors: Saoudi
authors: Direction of Environmental Health, Santé publique France, 12 rue du Val d'Osne, 94415 Saint Maurice Cedex, France.
authors: Marie
authors: M
authors: Pecheux
authors: Direction of Environmental Health, Santé publique France, 12 rue du Val d'Osne, 94415 Saint Maurice Cedex, France.
authors: Bénédicte
authors: B
authors: Berat
authors: Direction of Environmental Health, Santé publique France, 12 rue du Val d'Osne, 94415 Saint Maurice Cedex, France.
authors: Perrine
authors: P
authors: de Crouy-Chanel
authors: French National Institute for Health and Medical Research (Inserm), The "Elfe" INED-INSERM-EFS team, 133, boulevard Davout, 75020 Paris, France.
authors: Cécile
authors: C
authors: Zaros
authors: Direction of Environmental Health, Santé publique France, 12 rue du Val d'Osne, 94415 Saint Maurice Cedex, France.
authors: Serge
authors: S
authors: Brunel
authors: Direction of Environmental Health, Santé publique France, 12 rue du Val d'Osne, 94415 Saint Maurice Cedex, France.
authors: Corinne
authors: C
authors: Delamaire
authors: Direction of Environmental Health, Santé publique France, 12 rue du Val d'Osne, 94415 Saint Maurice Cedex, France.
authors: Alain
authors: A
authors: le Tertre
authors: Direction of Environmental Health, Santé publique France, 12 rue du Val d'Osne, 94415 Saint Maurice Cedex, France.
authors: Agnès
authors: A
authors: Lefranc
authors: Direction of Environmental Health, Santé publique France, 12 rue du Val d'Osne, 94415 Saint Maurice Cedex, France.
authors: Stéphanie
authors: S
authors: Vandentorren
authors: Direction of Environmental Health, Santé publique France, 12 rue du Val d'Osne, 94415 Saint Maurice Cedex, France.
authors: Laurence
authors: L
authors: Guldner
mesh_terms: D000293:Adolescent; D000328:Adult; D001559:Benzhydryl Compounds / Q000032:analysis / Q000633:toxicity; D015415:Biomarkers / Q000097:blood / Q000652:urine; D002648:Child; D004147:Dioxins / Q000032:analysis / Q000633:toxicity; D004784:Environmental Monitoring; D004785:Environmental Pollutants / Q000009:adverse effects* / Q000097:blood / Q000652:urine; D004787:Environmental Pollution / Q000009:adverse effects; D005260:Female; D005411:Flame Retardants / Q000032:analysis / Q000633:toxicity; D005602:France; D005663:Furans / Q000032:analysis / Q000633:toxicity; D006801:Humans; D008137:Longitudinal Studies; D010575:Pesticides / Q000032:analysis / Q000633:toxicity; D010636:Phenols / Q000032:analysis / Q000633:toxicity; D010795:Phthalic Acids / Q000032:analysis / Q000633:toxicity; D011078:Polychlorinated Biphenyls / Q000032:analysis / Q000633:toxicity; D011247:Pregnancy; D055815:Young Adult; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D015415:Biomarkers; D004147:Dioxins; D004785:Environmental Pollutants; D005411:Flame Retardants; D005663:Furans; D010575:Pesticides; D010636:Phenols; D010795:Phthalic Acids; D011078:Polychlorinated Biphenyls; C032279:phthalic acid; C006780:bisphenol A; D000098826:Bisphenol A Compounds
keywords: Biomonitoring; Endocrine disruptor; Environmental exposure; Metals; Pregnant women