title: Periportal low attenuation associated with liver metastasis from colorectal cancer: evaluation using multi-detector-row CT with pathological correlation.
abstract: OBJECTIVE
  Periportal low attenuation (PPLA) associated with metastatic liver cancer is occasionally seen on multi-detector-row CT (MDCT). The purpose of this study was to investigate the MDCT patterns of the PPLA and to correlate it with pathological findings.
  
  
  METHODS
  We retrospectively reviewed the MDCT images of 63 patients with metastatic liver cancers from colorectal adenocarcinoma. On MDCT scans, PPLA associated with liver metastasis was visualized in six patients with colorectal cancer. In these six patients who had undergone surgical resection, the radiologic-pathologic correlation was analyzed. All patients underwent a single contrast-enhanced MDCT within 1 month before surgical resection. The six liver cancers were pathologically proven to be moderately differentiated adenocarcinoma. We assessed the PPLA on MDCT concerning the distribution patterns and contrast enhancement with pathological correlation.
  
  
  RESULTS
  In five of the patients, the PPLA extended to the hilar side from metastatic liver cancer. Pathologically, there was no cancer invasion into the intra-hepatic periportal area; however, massive lymphedema and fibrosis occurred in all six cases.
  
  
  CONCLUSIONS
  PPLA on the hilar and peripheral sides of hepatic metastasis from colorectal cancer may be present suggesting lymphedema and fibrosis of portal tracts not always indicating cancer infiltration.
authors: Departments of Radiology, Oita University Faculty of Medicine, Yufu City, Oita, 879-5593, Japan.
authors: Ryo
authors: R
authors: Takaji
authors: Departments of Radiology, Oita University Faculty of Medicine, Yufu City, Oita, 879-5593, Japan. matsushu@oita-u.ac.jp.
authors: Shunro
authors: S
authors: Matsumoto
authors: Departments of Radiology, Oita University Faculty of Medicine, Yufu City, Oita, 879-5593, Japan.
authors: Maki
authors: M
authors: Kiyonaga
authors: Departments of Radiology, Oita University Faculty of Medicine, Yufu City, Oita, 879-5593, Japan.
authors: Yasunari
authors: Y
authors: Yamada
authors: Departments of Radiology, Oita University Faculty of Medicine, Yufu City, Oita, 879-5593, Japan.
authors: Hiromu
authors: H
authors: Mori
authors: Departments of Gastroenterological and Pediatric Surgery, Oita University Faculty of Medicine, Yufu City, Oita, Japan.
authors: Yukio
authors: Y
authors: Iwashita
authors: Departments of Gastroenterological and Pediatric Surgery, Oita University Faculty of Medicine, Yufu City, Oita, Japan.
authors: Masayuki
authors: M
authors: Ohta
authors: Departments of Gastroenterological and Pediatric Surgery, Oita University Faculty of Medicine, Yufu City, Oita, Japan.
authors: Masafumi
authors: M
authors: Inomata
authors: Departments of Molecular Pathology, Oita University Faculty of Medicine, Yufu City, Oita, Japan.
authors: Naoki
authors: N
authors: Hijiya
authors: Departments of Molecular Pathology, Oita University Faculty of Medicine, Yufu City, Oita, Japan.
authors: Masatsugu
authors: M
authors: Moriyama
authors: Departments of Radiology, Oita Red-cross Hospital, Oita, Japan.
authors: Hajime
authors: H
authors: Takaki
authors: Departments of Surgery, Oita Red-cross Hospital, Oita, Japan.
authors: Kengo
authors: K
authors: Fukuzawa
authors: Departments of Pathology, Oita Red-cross Hospital, Oita, Japan.
authors: Hirotoshi
authors: H
authors: Yonemasu
mesh_terms: D000368:Aged; D015179:Colorectal Neoplasms / Q000473:pathology*; D003287:Contrast Media; D005260:Female; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging* / Q000473:pathology*; D008113:Liver Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D061330:Multidetector Computed Tomography / Q000379:methods*; D011856:Radiographic Image Enhancement; D012189:Retrospective Studies
chemical_list: D003287:Contrast Media
keywords: Colorectal cancer; Liver metastasis; Multi-detector-row CT; Periportal low attenuation