title: Lifetime regular exercise affects the incident of different arrhythmias and improves organismal health in aging female Drosophila melanogaster.
abstract: We used Drosophila melanogaster as an animal model system to study the impact of exercise training initiated early in life on cardiac function using a well-established model of inherent myogenic properties of the heart and discussed the changes on myosin, a myocardial contractile protein. We also explored the effect of early physical exercise on organismal aging by analyzing the wake-sleep pattern using a Drosophila activity monitor system. We found that a variety of arrhythmias are part of the heart spectrum in old flies after a lifetime of physical exercise as evidenced by reducing the incidence of fibrillations and increasing the occurrence of bradycardias. Maintenance of myocardial myosin levels may be an underlying contributor to these exercise-induced improvements in cardiac function at an advanced age. Moreover, we found that exercise training resulted in improved sleep quality by ameliorating age-related sleep inefficiency, fragmentation and sleep consolidation.
authors: Key Laboratory of Physical Fitness and Exercise Rehabilitation of Hunan Province, Hunan Normal University, Changsha, Hunan Province, China. lanzheng@hunnu.edu.cn.
authors: Lan
authors: L
authors: Zheng
authors: Key Laboratory of Physical Fitness and Exercise Rehabilitation of Hunan Province, Hunan Normal University, Changsha, Hunan Province, China.
authors: Qiu Fang
authors: QF
authors: Li
authors: Key Laboratory of Physical Fitness and Exercise Rehabilitation of Hunan Province, Hunan Normal University, Changsha, Hunan Province, China.
authors: Liu
authors: L
authors: Ni
authors: Key Laboratory of Physical Fitness and Exercise Rehabilitation of Hunan Province, Hunan Normal University, Changsha, Hunan Province, China.
authors: Hui
authors: H
authors: Wang
authors: Key Laboratory of Physical Fitness and Exercise Rehabilitation of Hunan Province, Hunan Normal University, Changsha, Hunan Province, China.
authors: Xiang Cheng
authors: XC
authors: Ruan
authors: Heart Development Center, Hunan Normal University, Changsha, Hunan Province, China.
authors: Xiu Shan
authors: XS
authors: Wu
mesh_terms: D000375:Aging; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000503:physiopathology* / Q000517:prevention & control*; D004330:Drosophila; D005081:Exercise Therapy / Q000379:methods*; D005260:Female; D000070497:Healthy Lifestyle; D006321:Heart / Q000503:physiopathology; D009218:Myosins / Q000378:metabolism; D010805:Physical Conditioning, Animal / Q000379:methods*; D040242:Risk Reduction Behavior; D012727:Sex Characteristics; D016896:Treatment Outcome
chemical_list: D009218:Myosins
keywords: Anti-aging; Drosophila; Exercise; Healthy aging; Heart