title: Vortex-homogenized matrix solid-phase dispersion for the extraction of short chain chlorinated paraffins from indoor dust samples.
abstract: A simple and effective method for determining short chain chlorinated paraffins (SCCPs) in indoor dust is presented. The method employed a modified vortex-homogenized matrix solid-phase dispersion (VH-MSPD) prior to its detection by gas chromatography - electron-capture negative-ion mass spectrometry (GC-ECNI-MS) operating in the selected-ion-monitoring (SIM) mode. Under the best extraction conditions, 0.1-g of dust sample was dispersed with 0.1-g of silica gel by using vortex (2min) instead of using a mortar and pestle (3min). After that step, the blend was transferred to a glass column containing 3-g acidic silica gel, 2-g basic silica gel, and 2-g of deactivated silica gel, used as clean-up co-sorbents. Then, target analytes were eluted with 5mL of n-hexane/dichloromethane (2:1, v/v) mixture. The extract was evaporated to dryness under a gentle stream of nitrogen. The residue was then re-dissolved in n-hexane (10μL), and subjected to GC-ECNI-MS analysis. The limits of quantitation (LOQs) ranged from 0.06 to 0.25μg/g for each SCCP congener. Precision was less than 7% for both intra- and inter-day analysis. Trueness was above 89%, which was calculated by mean extraction recovery. The VH-MSPD combined with GC-ECNI-MS was successfully applied to quantitatively detect SCCPs from various indoor dust samples, and the concentrations ranged from 1.2 to 31.2μg/g.
authors: Department of Chemistry, National Central University, Chung-Li 320, Taiwan.
authors: Yu-Hsuan
authors: YH
authors: Chen
authors: Department of Chemistry, National Central University, Chung-Li 320, Taiwan.
authors: Chia-Yu
authors: CY
authors: Chang
authors: Department of Chemistry, National Central University, Chung-Li 320, Taiwan. Electronic address: wanghsiending@gmail.com.
authors: Wang-Hsien
authors: WH
authors: Ding
mesh_terms: D016902:Air Pollution, Indoor / Q000032:analysis*; D004391:Dust / Q000032:analysis*; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D006586:Hexanes / Q000737:chemistry; D057230:Limit of Detection; D008752:Methylene Chloride / Q000737:chemistry; D010232:Paraffin / Q000737:chemistry* / Q000302:isolation & purification*; D052616:Solid Phase Extraction
chemical_list: D004391:Dust; D006586:Hexanes; C026385:n-hexane; D008752:Methylene Chloride; D010232:Paraffin
keywords: GC-ECNI-MS; Indoor dust; Short chain chlorinated paraffins; Vortex-assisted matrix solid-phase dispersion