title: Antimalarial Activity of the Chemical Constituents of the Leaf Latex of Aloe pulcherrima Gilbert and Sebsebe.
abstract: Malaria is one of the three major global public health threats due to a wide spread resistance of the parasites to the standard antimalarial drugs. Considering this growing problem, the ethnomedicinal approach in the search for new antimalarial drugs from plant sources has proven to be more effective and inexpensive. The leaves ofAloe pulcherrimaGilbert and Sebsebe, an endemic Ethiopian plant, are locally used for the treatment of malaria and other infectious diseases. Application of the leaf latex ofA. pulcherrimaon preparative silica gel TLC led to the isolation of twoC-glycosylated anthrones, identified as nataloin (1) and 7-hydroxyaloin (2) by spectroscopic techniques (UV, IR, ¹H- and13C-NMR, HR-ESIMS). Both the latex and isolated compounds displayed antimalarial activity in a dose-independent manner using a four-day suppressive test, with the highest percent suppression of 56.2% achieved at 200 mg/kg/day for2. The results indicate that both the leaf latex ofA. pulcherrimaand its two major constituents are endowed with antiplasmodial activities, which support the traditional use of the leaves of the plant for the treatment of malaria.
authors: Department of Pharmacy, College of Health Sciences, Wollo University, P.O. Box 1145, Dessie, Ethiopia. ttekleab@gmail.com.
authors: Tekleab
authors: T
authors: Teka
authors: Department of Pharmaceutical Chemistry and Pharmacognosy, School of Pharmacy, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia. daniel.bisrat@aau.edu.et.
authors: Daniel
authors: D
authors: Bisrat
authors: Department of Pharmaceutical Chemistry and Pharmacognosy, School of Pharmacy, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia. mariamawit.yonathan@aau.edu.et.
authors: Mariamawit Yonathan
authors: MY
authors: Yeshak
authors: Department of Pharmaceutical Chemistry and Pharmacognosy, School of Pharmacy, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia. kaleab.asres@aau.edu.et.
authors: Kaleab
authors: K
authors: Asres
mesh_terms: D000504:Aloe / Q000737:chemistry*; D000818:Animals; D000873:Anthracenes / Q000008:administration & dosage* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000962:Antimalarials / Q000008:administration & dosage* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004195:Disease Models, Animal; D005002:Ethiopia; D007840:Latex / Q000737:chemistry; D008288:Malaria / Q000188:drug therapy*; D008519:Medicine, Traditional; D051379:Mice; D015394:Molecular Structure; D018512:Parasitemia / Q000188:drug therapy*; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry* / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D010962:Plasmodium berghei / Q000187:drug effects
chemical_list: D000873:Anthracenes; D000962:Antimalarials; D007840:Latex; D010936:Plant Extracts
keywords: 7-hydroxyaloin; Aloe pulcherrima; antimalarial; four-day suppressive; nataloin