title: Intrinsic and Innate Defenses of Neurons: Détente with the Herpesviruses.
abstract: Neuroinvasive herpesviruses have evolved to efficiently infect and establish latency in neurons. The nervous system has limited capability to regenerate, so immune responses therein are carefully regulated to be nondestructive, with dependence on atypical intrinsic and innate defenses. In this article we review studies of some of these noncanonical defense pathways and how herpesvirus gene products counter them, highlighting the contributions that primary neuronal in vitro models have made to our understanding of this field.
authors: Department of Molecular Biology and Princeton Neuroscience Institute, Princeton University, Princeton, New Jersey, USA.
authors: Lynn W
authors: LW
authors: Enquist
authors: Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA david.a.leib@dartmouth.edu.
authors: David A
authors: DA
authors: Leib
mesh_terms: D001343:Autophagy / Q000235:genetics / Q000276:immunology; D001370:Axonal Transport; D056970:Co-Repressor Proteins / Q000235:genetics / Q000276:immunology; D020868:Gene Silencing; D006564:Herpesviridae / Q000254:growth & development* / Q000276:immunology; D006655:Histone Deacetylases / Q000235:genetics / Q000276:immunology; D056466:Histone Demethylases / Q000235:genetics / Q000276:immunology; D006801:Humans; D017874:Immediate-Early Proteins / Q000235:genetics / Q000276:immunology; D057131:Immune Evasion; D007113:Immunity, Innate; D007372:Interferons / Q000235:genetics / Q000276:immunology; D035683:MicroRNAs / Q000235:genetics / Q000276:immunology; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000276:immunology; D009474:Neurons / Q000276:immunology / Q000821:virology*; D015398:Signal Transduction; D044767:Ubiquitin-Protein Ligases / Q000235:genetics / Q000276:immunology; D017735:Virus Latency / Q000276:immunology*
chemical_list: D056970:Co-Repressor Proteins; D017874:Immediate-Early Proteins; C546110:MIRN138 microRNA, human; D035683:MicroRNAs; D009419:Nerve Tissue Proteins; C121019:RCOR1 protein, human; D007372:Interferons; D056466:Histone Demethylases; C495195:KDM1A protein, human; D044767:Ubiquitin-Protein Ligases; C051804:Vmw110 protein, Human herpesvirus 1; D006655:Histone Deacetylases
keywords: herpesviruses; innate immunity; intrinsic immunity; neuroimmunology; neurotropic viruses