title: 3D Cohort Study: The Integrated Research Network in Perinatology of Quebec and Eastern Ontario.
abstract: The 3D Cohort Study (Design, Develop, Discover) was established to help bridge knowledge gaps about the links between various adverse exposures during pregnancy with birth outcomes and later health outcomes in children.
  
  
  
  Pregnant women and their partners were recruited during the first trimester from nine sites in Quebec and followed along with their children through to 2 years of age. Questionnaires were administered during pregnancy and post-delivery to collect information on demographics, mental health and life style, medical history, psychosocial measures, diet, infant growth, and neurodevelopment. Information on the delivery and newborn outcomes were abstracted from medical charts. Biological specimens were collected from mothers during each trimester, fathers (once during the pregnancy), and infants (at delivery and 2 years of age) for storage in a biological specimen bank.
  
  
  
  Of the 9864 women screened, 6348 met the eligibility criteria and 2366 women participated in the study (37% of eligible women). Among women in the 3D cohort, 1721 of their partners (1704 biological fathers) agreed to participate (73%). Two thousand two hundred and nineteen participants had a live singleton birth (94%). Prenatal blood and urine samples as well as vaginal secretions were collected for ≥98% of participants, cord blood for 81% of livebirths, and placental tissue for 89% of livebirths.
  
  
  
  The 3D Cohort Study combines a rich bank of multiple biological specimens with extensive clinical, life style, and psychosocial data. This data set is a valuable resource for studying the developmental etiology of birth and early childhood neurodevelopmental outcomes.
authors: Université de Montréal, Montreal, QC, Canada.|Centre hospitalier universitaire Sainte-Justine, Montreal, QC, Canada.|Centre de recherche du Centre Hospitalier de l'Université de Sherbrooke, Montreal, QC, Canada.
authors: William D
authors: WD
authors: Fraser
authors: Centre hospitalier universitaire Sainte-Justine, Montreal, QC, Canada.|McGill University, Montreal, QC, Canada.|McGill University Health Centre, Montreal, QC, Canada.
authors: Gabriel D
authors: 0000-0002-3139-0238
authors: GD
authors: Shapiro
authors: Université de Montréal, Montreal, QC, Canada.|Centre hospitalier universitaire Sainte-Justine, Montreal, QC, Canada.
authors: François
authors: F
authors: Audibert
authors: University of Ottawa, Montreal, QC, Canada.
authors: Lise
authors: L
authors: Dubois
authors: Centre de recherche du Centre Hospitalier de l'Université de Sherbrooke, Montreal, QC, Canada.
authors: Jean-Charles
authors: JC
authors: Pasquier
authors: Université Laval, Montreal, QC, Canada.
authors: Pierre
authors: P
authors: Julien
authors: Université de Montréal, Montreal, QC, Canada.|Centre hospitalier universitaire Sainte-Justine, Montreal, QC, Canada.
authors: Anick
authors: A
authors: Bérard
authors: Université Laval, Montreal, QC, Canada.|Centre de recherche du Centre hospitalier universitaire de Québec-Université Laval, Montreal, QC, Canada.
authors: Gina
authors: G
authors: Muckle
authors: McGill University, Montreal, QC, Canada.|McGill University Health Centre, Montreal, QC, Canada.
authors: Jacquetta
authors: J
authors: Trasler
authors: Université de Montréal, Montreal, QC, Canada.|Centre hospitalier universitaire Sainte-Justine, Montreal, QC, Canada.
authors: Richard E
authors: RE
authors: Tremblay
authors: Jewish General Hospital, Montreal, QC, Canada.
authors: Haim
authors: H
authors: Abenhaim
authors: Université de Montréal, Montreal, QC, Canada.|Hôpital du Sacré-Cœur de Montréal, Montreal, QC, Canada.
authors: Michel
authors: M
authors: Welt
authors: Centre hospitalier de l'Université de Montréal, Montreal, QC, Canada.
authors: Marie-Josée
authors: MJ
authors: Bédard
authors: Clinique OVO, Montreal, QC, Canada.
authors: François
authors: F
authors: Bissonnette
authors: Université Laval, Montreal, QC, Canada.
authors: Emmanuel
authors: E
authors: Bujold
authors: McGill University, Montreal, QC, Canada.|McGill University Health Centre, Montreal, QC, Canada.
authors: Robert
authors: R
authors: Gagnon
authors: Université de Montréal, Montreal, QC, Canada.|Centre hospitalier universitaire Sainte-Justine, Montreal, QC, Canada.
authors: Jacques L
authors: JL
authors: Michaud
authors: CIUSSS de l'ouest de l'île de Montréal, Hôpital St. Mary's, Montreal, QC, Canada.
authors: Isabelle
authors: I
authors: Girard
authors: Centre de recherche du Centre Hospitalier de l'Université de Sherbrooke, Montreal, QC, Canada.
authors: Jean-Marie
authors: JM
authors: Moutquin
authors: Université Laval, Montreal, QC, Canada.
authors: Isabelle
authors: I
authors: Marc
authors: McGill University Health Centre, Montreal, QC, Canada.|Research Institute of the McGill University Health Centre, Montreal, QC, Canada.
authors: Patricia
authors: P
authors: Monnier
authors: Université de Montréal, Montreal, QC, Canada.|Centre hospitalier universitaire Sainte-Justine, Montreal, QC, Canada.
authors: Jean R
authors: JR
authors: Séguin
authors: Université de Montréal, Montreal, QC, Canada.|Centre hospitalier universitaire Sainte-Justine, Montreal, QC, Canada.
authors: Zhong-Cheng
authors: ZC
authors: Luo
mesh_terms: D000293:Adolescent; D000328:Adult; D004522:Educational Status; D005260:Female; D006801:Humans; D008019:Life Style; D008297:Male; D008423:Maternal Age; D008875:Middle Aged; D065886:Neurodevelopmental Disorders / Q000453:epidemiology*; D009864:Ontario / Q000453:epidemiology; D010298:Parity; D011247:Pregnancy; D011295:Prenatal Care / Q000706:statistics & numerical data; D011297:Prenatal Exposure Delayed Effects / Q000453:epidemiology*; D011792:Quebec / Q000453:epidemiology; D012959:Socioeconomic Factors; D013048:Specimen Handling / Q000706:statistics & numerical data; D011795:Surveys and Questionnaires; D055815:Young Adult
keywords: adverse birth outcomes; biological markers; infant development; pregnancy cohort study