title: The genome of serotype VI Streptococcus agalactiae serotype VI and comparative analysis.
abstract: Streptococcus agalactiae (GBS) causes serious infections in humans and other species. A total of 25 complete GBS genomes, including the first sequenced serotype VI genome (GBS-M002), were compared in this study. The power law model suggested that the pan-genome of GBS is open, with approximately 1300 genes in the core genome of GBS, accounting for approximately 60% of the average genome content. GBS-M002 has 73 specific genes and is one of the five strains containing >60 specific genes. Based on COG (Cluster of Orthologous Groups of proteins) functional classification, 24% of the genes related to defense mechanisms are specific among the strains. A phylogenetic tree shows that GBS-M002 is closely related to certain strains of serotypes III and V from humans and to isolates of unknown serotype from dog and bovine hosts, suggesting the universal infection potential of GBS from humans to other mammal and fish hosts.
authors: State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, People's Republic of China.
authors: En-Ming
authors: EM
authors: He
authors: Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center at Shanghai, Shanghai, People's Republic of China.
authors: Cheng-Wen
authors: CW
authors: Chen
authors: The Institutes of Biology and Medical Sciences, Soochow University, Suzhou, Jiangsu, People's Republic of China.
authors: Yong
authors: Y
authors: Guo
authors: Molecular Infectious Disease Research Center, Chang Gung Memorial Hospital, Kweishan, Taoyuan, Taiwan; Department of Pediatrics, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kweishan, Taoyuan, Taiwan.
authors: Mei-Hua
authors: MH
authors: Hsu
authors: Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center at Shanghai, Shanghai, People's Republic of China.
authors: Liang
authors: L
authors: Zhang
authors: Molecular Infectious Disease Research Center, Chang Gung Memorial Hospital, Kweishan, Taoyuan, Taiwan; Department of Pediatrics, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kweishan, Taoyuan, Taiwan.
authors: Hsiu-Ling
authors: HL
authors: Chen
authors: State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, People's Republic of China; Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center at Shanghai, Shanghai, People's Republic of China.
authors: Guo-Ping
authors: GP
authors: Zhao
authors: Molecular Infectious Disease Research Center, Chang Gung Memorial Hospital, Kweishan, Taoyuan, Taiwan; Department of Pediatrics, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kweishan, Taoyuan, Taiwan. Electronic address: chchiu@cgmh.org.tw.
authors: Cheng-Hsun
authors: CH
authors: Chiu
authors: State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, People's Republic of China; Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center at Shanghai, Shanghai, People's Republic of China. Electronic address: zhouy@fudan.edu.cn.
authors: Yan
authors: Y
authors: Zhou
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D002417:Cattle; D004285:Dogs; D016680:Genome, Bacterial; D044404:Genomic Islands / Q000235:genetics; D006801:Humans; D010802:Phylogeny; D017422:Sequence Analysis, DNA; D013292:Streptococcus agalactiae / Q000235:genetics* / Q000302:isolation & purification / Q000472:pathogenicity*
chemical_list: D001426:Bacterial Proteins
keywords: Genomic analysis; Pan-genome; Streptococcus agalactiae