title: Advances in the development of aptamer drug conjugates for targeted drug delivery.
abstract: A key goal of modern medicine is target-specific therapeutic intervention. However, most drugs lack selectivity, resulting in 'off-target' side effects. To address the requirements of 'targeted therapy,' aptamers, which are artificial oligonucleotides, have been used as novel targeting ligands to construct aptamer drug conjugates (ApDC) that can specifically bind to a broad spectrum of targets, including diseased cells. Accordingly, the application of aptamers in targeted drug delivery has attracted broad interest due to their impressive selectivity and affinity, low immunogenicity, easy synthesis with high reproducibility, facile modification, and relatively rapid tissue penetration with no toxicity. Functionally, aptamers themselves can be used as macromolecular drugs, and they are also commonly used in biomarker discovery and targeted drug delivery. In this review, we will highlight the most recent advances in the development of aptamers and aptamer conjugates, and discuss their potential in targeted therapy. WIREs Nanomed Nanobiotechnol 2017, 9:e1438. doi: 10.1002/wnan.1438 For further resources related to this article, please visit the WIREs website.
authors: Xiangya Hospital, Central South University, Changsha, China.
authors: Ke
authors: K
authors: Chen
authors: Xiangya Hospital, Central South University, Changsha, China.
authors: Bo
authors: B
authors: Liu
authors: Xiangya Hospital, Central South University, Changsha, China.
authors: Bo
authors: B
authors: Yu
authors: Xiangya Hospital, Central South University, Changsha, China.
authors: Wen
authors: W
authors: Zhong
authors: Xiangya Hospital, Central South University, Changsha, China.
authors: Yi
authors: Y
authors: Lu
authors: Xiangya Hospital, Central South University, Changsha, China.
authors: Jiani
authors: J
authors: Zhang
authors: Xiangya Hospital, Central South University, Changsha, China.
authors: Jie
authors: J
authors: Liao
authors: Xiangya Hospital, Central South University, Changsha, China.|Molecular Science and Biomedicine Laboratory, Hunan University, Changsha, China.|State Key Laboratory for Chemo/Bio-Sensing and Chemometrics, Hunan University, Changsha, China.|College of Chemistry and Chemical Engineering, Hunan University, Changsha, China.|College of Biology, Hunan University, Changsha, China.|Collaborative Research Center of Molecular Engineering for Theranostics, Hunan University, Changsha, China.
authors: Jun
authors: J
authors: Liu
authors: Xiangya Hospital, Central South University, Changsha, China.
authors: Ying
authors: Y
authors: Pu
authors: Molecular Science and Biomedicine Laboratory, Hunan University, Changsha, China.|State Key Laboratory for Chemo/Bio-Sensing and Chemometrics, Hunan University, Changsha, China.|College of Chemistry and Chemical Engineering, Hunan University, Changsha, China.|College of Biology, Hunan University, Changsha, China.|Collaborative Research Center of Molecular Engineering for Theranostics, Hunan University, Changsha, China.
authors: Liping
authors: L
authors: Qiu
authors: Molecular Science and Biomedicine Laboratory, Hunan University, Changsha, China.|State Key Laboratory for Chemo/Bio-Sensing and Chemometrics, Hunan University, Changsha, China.|College of Chemistry and Chemical Engineering, Hunan University, Changsha, China.|College of Biology, Hunan University, Changsha, China.|Collaborative Research Center of Molecular Engineering for Theranostics, Hunan University, Changsha, China.|Department of Chemistry and Department of Physiology and Functional Genomics, Center for Research at the Bio/Nano Interface, UF Health Cancer Center, University of Florida, Gainesville, FL, USA.
authors: Liqin
authors: L
authors: Zhang
authors: Xiangya Hospital, Central South University, Changsha, China.
authors: Huixia
authors: H
authors: Liu
authors: Molecular Science and Biomedicine Laboratory, Hunan University, Changsha, China.|State Key Laboratory for Chemo/Bio-Sensing and Chemometrics, Hunan University, Changsha, China.|College of Chemistry and Chemical Engineering, Hunan University, Changsha, China.|College of Biology, Hunan University, Changsha, China.|Collaborative Research Center of Molecular Engineering for Theranostics, Hunan University, Changsha, China.|Department of Chemistry and Department of Physiology and Functional Genomics, Center for Research at the Bio/Nano Interface, UF Health Cancer Center, University of Florida, Gainesville, FL, USA.
authors: Weihong
authors: W
authors: Tan
mesh_terms: D000818:Animals; D052157:Aptamers, Nucleotide; D035843:Biomedical Research; D002460:Cell Line; D004337:Drug Carriers; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D051379:Mice
chemical_list: D052157:Aptamers, Nucleotide; D004337:Drug Carriers