title: Identification of Novel Human Breast Carcinoma (MDA-MB-231) Cell Growth Modulators from a Carbohydrate-Based Diversity Oriented Synthesis Library.
abstract: The application of a cell-based growth inhibition on a library of skeletally different glycomimetics allowed for the selection of a hexahydro-2H-furo[3,2-b][1,4]oxazine compound as candidate inhibitors of MDA-MB-231 cell growth. Subsequent synthesis of analogue compounds and preliminary biological studies validated the selection of a valuable hit compound with a novel polyhydroxylated structure for the modulation of the breast carcinoma cell cycle mechanism.
authors: Department of Chemistry "Ugo Schiff", University of Florence, Via della Lastruccia 13, 50019 Sesto Fiorentino, Florence, Italy. elena.lenci@unifi.it.
authors: Elena
authors: E
authors: Lenci
authors: Department of Chemistry "Ugo Schiff", University of Florence, Via della Lastruccia 13, 50019 Sesto Fiorentino, Florence, Italy. riccardo.innocenti@stud.unifi.it.
authors: Riccardo
authors: R
authors: Innocenti
authors: Department of Clinical and Experimental Biomedical Science "Mario Serio", University of Florence, Viale Morgagni 50, 50134 Florence, Italy. alessio.biagioni@unifi.it.
authors: Alessio
authors: A
authors: Biagioni
authors: Department of Chemistry "Ugo Schiff", University of Florence, Via della Lastruccia 13, 50019 Sesto Fiorentino, Florence, Italy. gloria.menchi@unifi.it.
authors: Gloria
authors: G
authors: Menchi
authors: Department of Clinical and Experimental Biomedical Science "Mario Serio", University of Florence, Viale Morgagni 50, 50134 Florence, Italy. francesca.bianchini@unifi.it.
authors: Francesca
authors: F
authors: Bianchini
authors: Department of Chemistry "Ugo Schiff", University of Florence, Via della Lastruccia 13, 50019 Sesto Fiorentino, Florence, Italy. andrea.trabocchi@unifi.it.
authors: Andrea
authors: A
authors: Trabocchi
mesh_terms: D032701:Biomimetics; D001943:Breast Neoplasms / Q000188:drug therapy; D002241:Carbohydrates / Q000737:chemistry*; D002453:Cell Cycle / Q000187:drug effects; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D005260:Female; D006131:Growth Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D010078:Oxazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D054852:Small Molecule Libraries / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D002241:Carbohydrates; D006131:Growth Inhibitors; D010078:Oxazines; D054852:Small Molecule Libraries
keywords: cancer; chemical diversity; heterocycles; sugars