title: Glutathione peroxidase 4: a new player in neurodegeneration?
abstract: Glutathione peroxidase 4 (GPx4) is an antioxidant enzyme reported as an inhibitor of ferroptosis, a recently discovered non-apoptotic form of cell death. This pathway was initially described in cancer cells and has since been identified in hippocampal and renal cells. In this Perspective, we propose that inhibition of ferroptosis by GPx4 provides protective mechanisms against neurodegeneration. In addition, we suggest that selenium deficiency enhances susceptibility to ferroptotic processes, as well as other programmed cell death pathways due to a reduction in GPx4 activity. We review recent studies of GPx4 with an emphasis on neuronal protection, and discuss the relevance of selenium levels on its enzymatic activity.
authors: The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia.
authors: B R
authors: BR
authors: Cardoso
authors: The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia.|Elemental Bio-imaging Facility, University of Technology Sydney, Broadway, NSW, Australia.
authors: D J
authors: DJ
authors: Hare
authors: The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia.
authors: A I
authors: AI
authors: Bush
authors: The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia.
authors: B R
authors: BR
authors: Roberts
mesh_terms: D000818:Animals; D016923:Cell Death / Q000502:physiology; D005979:Glutathione Peroxidase / Q000378:metabolism* / Q000502:physiology*; D006801:Humans; D019636:Neurodegenerative Diseases / Q000517:prevention & control; D000080662:Phospholipid Hydroperoxide Glutathione Peroxidase; D012643:Selenium / Q000378:metabolism
chemical_list: D000080662:Phospholipid Hydroperoxide Glutathione Peroxidase; D005979:Glutathione Peroxidase; D012643:Selenium