title: E3 ubiquitin ligase Cbl-b activates the p53 pathway by targeting Siva1, a negative regulator of ARF, in FLT3 inhibitor-resistant acute myeloid leukemia.
authors: Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.|Division of Pharmaceutics, College of Pharmacy, The Ohio State University, Columbus, OH, USA.
authors: I-K
authors: IK
authors: Park
authors: Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA.
authors: W
authors: W
authors: Blum
authors: Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.|Division of Pharmaceutics, College of Pharmacy, The Ohio State University, Columbus, OH, USA.
authors: S D
authors: SD
authors: Baker
authors: Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.|Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA.
authors: M A
authors: MA
authors: Caligiuri
mesh_terms: D051017:Apoptosis Regulatory Proteins / Q000037:antagonists & inhibitors*; D019008:Drug Resistance, Neoplasm; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000378:metabolism*; D050721:Proto-Oncogene Proteins c-cbl / Q000502:physiology*; D015398:Signal Transduction; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism; D044767:Ubiquitin-Protein Ligases / Q000502:physiology; D051941:fms-Like Tyrosine Kinase 3 / Q000037:antagonists & inhibitors
chemical_list: D051017:Apoptosis Regulatory Proteins; C106549:SIVA1 protein, human; D016159:Tumor Suppressor Protein p53; D050721:Proto-Oncogene Proteins c-cbl; D044767:Ubiquitin-Protein Ligases; D051941:fms-Like Tyrosine Kinase 3