title: Cohort profile: the Baependi Heart Study-a family-based, highly admixed cohort study in a rural Brazilian town.
abstract: Cardiovascular disease (CVD) is a major challenge to global health. The same epidemiological transition scenario is replayed as countries develop, but with variations based on environment, culture and ethnic mixture. The Baependi Heart Study was set up in 2005 to develop a longitudinal family-based cohort study that reflects on some of the genetic and lifestyle-related peculiarities of the Brazilian populations, in order to evaluate genetic and environmental influences on CVD risk factor traits.
  
  
  
  Probands were recruited in Baependi, a small rural town in the state of Minas Gerais, Brazil, following by first-degree and then increasingly more distant relatives. The first follow-up wave took place in 2010, and the second in 2016. At baseline, the study evaluated 1691 individuals across 95 families. Cross-sectional data have been collected for 2239 participants.
  
  
  
  Environmental and lifestyle factors and measures relevant to cardiovascular health have been reported. Having expanded beyond cardiovascular health outcomes, the phenotype datasets now include genetics, biochemistry, anthropometry, mental health, sleep and circadian rhythms. Many of these have yielded heritability estimates, and a shared genetic background of anxiety and depression has recently been published. In spite of universal access to electricity, the population has been found to be strongly shifted towards morningness compared with metropolitan areas.
  
  
  
  A new follow-up, marking 10 years of the study, is ongoing in 2016, in which data are collected as in 2010 (with the exception of the neuropsychiatric protocol). In addition to this, a novel questionnaire package collecting information about intelligence, personality and spirituality is being planned. The data set on circadian rhythms and sleep will be amended through additional questionnaires, actimetry, home sleep EEG recording and dim light melatonin onset (DLMO) analysis. Finally, the anthropometric measures will be expanded by adding three-dimensional facial photography, voice recording and anatomical brain MRI.
authors: Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK.
authors: Kieren J
authors: 0000-0002-1639-4281
authors: KJ
authors: Egan
authors: Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK.|Laboratory of Genetics and Molecular Cardiology, Heart Institute (Incor), University of São Paulo Medical School, São Paulo, Brazil.|Institute of Psychiatry, University of São Paulo Medical School, São Paulo, Brazil.
authors: Malcolm
authors: 0000-0002-9911-9436
authors: M
authors: von Schantz
authors: Laboratory of Genetics and Molecular Cardiology, Heart Institute (Incor), University of São Paulo Medical School, São Paulo, Brazil.
authors: André B
authors: AB
authors: Negrão
authors: Laboratory of Genetics and Molecular Cardiology, Heart Institute (Incor), University of São Paulo Medical School, São Paulo, Brazil.
authors: Hadassa C
authors: 0000-0002-4982-3425
authors: HC
authors: Santos
authors: Laboratory of Genetics and Molecular Cardiology, Heart Institute (Incor), University of São Paulo Medical School, São Paulo, Brazil.
authors: Andréa R V R
authors: AR
authors: Horimoto
authors: Laboratory of Genetics and Molecular Cardiology, Heart Institute (Incor), University of São Paulo Medical School, São Paulo, Brazil.
authors: Nubia E
authors: NE
authors: Duarte
authors: Laboratory of Genetics and Molecular Cardiology, Heart Institute (Incor), University of São Paulo Medical School, São Paulo, Brazil.
authors: Guilherme C
authors: GC
authors: Gonçalves
authors: Department of Statistics, University of São Paulo, São Paulo, Brazil.
authors: Júlia M P
authors: JM
authors: Soler
authors: Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.
authors: Mariza
authors: 0000-0003-2329-2686
authors: M
authors: de Andrade
authors: Sleep Laboratory, Pulmonary Division, Heart Institute (Incor), University of São Paulo Medical School, São Paulo, Brazil.
authors: Geraldo
authors: G
authors: Lorenzi-Filho
authors: Institute of Psychiatry, University of São Paulo Medical School, São Paulo, Brazil.
authors: Homero
authors: 0000-0001-5123-8295
authors: H
authors: Vallada
authors: Institute of Psychiatry, University of São Paulo Medical School, São Paulo, Brazil.
authors: Tâmara P
authors: TP
authors: Taporoski
authors: School of Arts, Science, and Humanities, University of São Paulo, São Paulo, Brazil.
authors: Mario
authors: 0000-0002-5257-591X
authors: M
authors: Pedrazzoli
authors: Natura Innovation and Product Technology Ltd., Cajamar, SP, Brazil.
authors: Ana P
authors: 0000-0001-9884-4735
authors: AP
authors: Azambuja
authors: Laboratory of Genetics and Molecular Cardiology, Heart Institute (Incor), University of São Paulo Medical School, São Paulo, Brazil.|Department of Physiology, Federal University of Juiz de Fora, Juiz de Fora, Brazil.
authors: Camila M
authors: CM
authors: de Oliveira
authors: Department of Physiology, Federal University of Juiz de Fora, Juiz de Fora, Brazil.
authors: Rafael O
authors: RO
authors: Alvim
authors: Laboratory of Genetics and Molecular Cardiology, Heart Institute (Incor), University of São Paulo Medical School, São Paulo, Brazil.
authors: José E
authors: 0000-0001-5464-1792
authors: JE
authors: Krieger
authors: Laboratory of Genetics and Molecular Cardiology, Heart Institute (Incor), University of São Paulo Medical School, São Paulo, Brazil.
authors: Alexandre C
authors: AC
authors: Pereira
mesh_terms: D000328:Adult; D000886:Anthropometry; D001938:Brazil / Q000453:epidemiology; D002318:Cardiovascular Diseases / Q000208:ethnology / Q000209:etiology* / Q000235:genetics / Q000523:psychology; D002940:Circadian Rhythm; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D066264:Datasets as Topic; D005006:Ethnicity; D005190:Family; D005260:Female; D006304:Health Status; D006801:Humans; D008019:Life Style; D008297:Male; D008603:Mental Health; D008875:Middle Aged; D010641:Phenotype; D012307:Risk Factors; D012424:Rural Population; D012890:Sleep; D012931:Social Environment; D011795:Surveys and Questionnaires
keywords: Cardiovascular disease; Cohort studies; Family design; MENTAL HEALTH; Risk factors; Sleep