title: Exploratory Population PK Analysis of Dupilumab, a Fully Human Monoclonal Antibody Against IL-4Rα, in Atopic Dermatitis Patients and Normal Volunteers.
abstract: An exploratory population pharmacokinetic model for functional dupilumab was developed. Data from healthy volunteers and patients with atopic dermatitis (AD) receiving intravenous or subcutaneous doses were integrated. The data included 197 participants (2,518 measurements of dupilumab in serum) from six phase I and II studies. The data were analyzed using stochastic approximation expectation-maximization and importance sampling methods. The best structural model was a two-compartment model with parallel linear and Michaelis-Menten elimination from the central compartment. Estimated parameters were: central volume 2.74 L, elimination rate 0.0459 d-1, central-to-peripheral rate 0.0652 d-1, peripheral-to-central rate 0.129 d-1, bioavailability 60.7%, maximal target-mediated elimination rate 0.968 mg/L/d, and Michaelis-Menten constant 0.01 mg/L. Body weight was a significant covariate of the central volume. No gender effect was observed when controlling for weight. No differences between healthy volunteers and patients with AD were found. The model adequately described dupilumab pharmacokinetics for intravenous and subcutaneous routes of administration.
authors: Regeneron Pharmaceuticals, Inc., Tarrytown, New York, USA.
authors: P
authors: P
authors: Kovalenko
authors: Regeneron Pharmaceuticals, Inc., Tarrytown, New York, USA.
authors: A T
authors: AT
authors: DiCioccio
authors: Regeneron Pharmaceuticals, Inc., Tarrytown, New York, USA.
authors: J D
authors: JD
authors: Davis
authors: Sanofi, Bridgewater, New Jersey, USA.
authors: M
authors: M
authors: Li
authors: Regeneron Pharmaceuticals, Inc., Tarrytown, New York, USA.
authors: M
authors: M
authors: Ardeleanu
authors: Regeneron Pharmaceuticals, Inc., Tarrytown, New York, USA.
authors: Nmh
authors: N
authors: Graham
authors: Regeneron Pharmaceuticals, Inc., Tarrytown, New York, USA.
authors: R
authors: R
authors: Soltys
mesh_terms: D061605:Administration, Intravenous; D000328:Adult; D000911:Antibodies, Monoclonal / Q000008:administration & dosage* / Q000493:pharmacokinetics; D061067:Antibodies, Monoclonal, Humanized; D001682:Biological Availability; D017321:Clinical Trials, Phase I as Topic; D017322:Clinical Trials, Phase II as Topic; D003876:Dermatitis, Atopic / Q000188:drug therapy* / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007279:Injections, Subcutaneous; D008297:Male; D008657:Metabolic Clearance Rate; D016896:Treatment Outcome
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; C582203:dupilumab