title: More Cases of Benign Testicular Teratomas are Detected in Adults than in Children. A Clinicopathological Study of 543 Testicular Germ Cell Tumor Cases.
abstract: Benign testicular teratomas are always thought to be pediatric neoplasms and previously all the teratoid tumors in the adult testis regarded as malignant. Recently, three publications reported benign testicular teratomas in adulthood and the latest WHO classification refers them as "prepubertal type of teratomas" which rarely appear in adulthood. These neoplasms behave benign and seemingly analogous independently whether they appear in pre- or postpubertal patients. The aim of our study was to investigate the frequency of benign testicular teratomas both in children and adults. 593 cases of testicular neoplasms were found in a period of 17 years ranging from 1998 to 2014 in the archive of our department (Department of Pathology, Medical Center, Pécs University). 543 cases diagnosed as germ cell tumor which have all been further evaluated in conjunction with the clinical data available. Of all germ cell tumor cases 14 (2.5 %) were pure teratomas. Ten out of 14 were the WHO-defined "conventional" teratoma, 4 of the 14 were the "benign or the so called prepubertal type" from which three occurred in adult patients. Only one of the 14 occurred in childhood, indicating that benign prepubertal type teratomas -which are regarded generally as childhood tumors- are more frequently detected in adults than in children. Benign adult testicular teratomas comprised 21 % of all pure teratoma cases in our series. Practicioners in the field have to be aware of its existence also in adulthood to avoid overtreatment and not to expose their patients to unnecessary chemotherapy, retroperitoneal lymphadenectomy (RLA) and the potential complications of these interventions.
authors: Faculty of Medicine, Department of Pathology 2nd Diagnostic Laboratory, Rákóczi u 2, PÉCS, H-7624, Hungary. semjen.david@pte.hu.
authors: Semjén
authors: S
authors: David
authors: Faculty of Medicine, Department of Paediatrics, Pécs University, József Attila u.7, Pécs, H-7623, Hungary.
authors: Farkas
authors: F
authors: András
authors: Faculty of Medicine, Department of Pathology 2nd Diagnostic Laboratory, Rákóczi u 2, PÉCS, H-7624, Hungary.
authors: Kalman
authors: K
authors: Endre
authors: Faculty of Medicine, Department of Pathology 2nd Diagnostic Laboratory, Rákóczi u 2, PÉCS, H-7624, Hungary.
authors: Kaszas
authors: K
authors: Balint
authors: Faculty of Health Sciences, Department of Diagnostic, Pécs University, Vörömarty u. 4, Pécs, H-7621, Hungary.
authors: Kovács
authors: K
authors: Árpad
authors: Faculty of Medicine, Department of Urology, Pécs University, Munkácsy M. u. 2, Pécs, H-7621, Hungary.
authors: Pusztai
authors: P
authors: Csaba
authors: Department of Molecular Cell Biology, Leiden University Medical Center, Einthovenweg 20, Leiden, 2300RC, The Netherlands.
authors: Szuhai
authors: S
authors: Karoly
authors: Faculty of Medicine, Department of Pathology 2nd Diagnostic Laboratory, Rákóczi u 2, PÉCS, H-7624, Hungary.
authors: Tornóczky
authors: T
authors: Tamás
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D006801:Humans; D008197:Lymph Node Excision / Q000379:methods; D008297:Male; D008875:Middle Aged; D009373:Neoplasms, Germ Cell and Embryonal / Q000473:pathology*; D012189:Retrospective Studies; D013724:Teratoma / Q000473:pathology*; D013736:Testicular Neoplasms / Q000473:pathology*; D055815:Young Adult
keywords: Benign teratoma; Germ cell tumor; Mature teratoma; Postpubertal; Testicular neoplasms; Testis