title: Molecular Imaging of Huntington's Disease.
abstract: The onset and the clinical progression of Huntington Disease (HD) is influenced by several events prompted by a genetic mutation that affects several organs tissues including different regions of the brain. In the last decades years, Positron Emission Tomography (PET) and Magnetic Resonance Imaging (MRI) helped to deepen the knowledge of neurodegenerative mechanisms that guide to clinical symptoms. Brain imaging with PET represents a tool to investigate the physiopathology occurring in the brain and it has been used to predict the age of onset of the disease and to evaluate the therapeutic efficacy of new drugs. This article reviews the contribution of PET and MRI in the research field on Huntington's disease, focusing in particular on some most relevant achievements that have helped recognize the molecular changes, the clinical symptoms and evolution of the disease. J. Cell. Physiol. 232: 1988-1993, 2017. © 2016 Wiley Periodicals, Inc.
authors: Department of Nuclear Medicine, S. Andrea Hospital, La Spezia, Italy.
authors: Andrea
authors: A
authors: Ciarmiello
authors: Department of Neurology, S. Andrea Hospital, La Spezia, Italy.|Institute of Radiology and Nuclear Medicine, Stadtspital Triemli, Zurich, Switzerland.
authors: Giampiero
authors: G
authors: Giovacchini
authors: Department of Nuclear Medicine, S. Andrea Hospital, La Spezia, Italy.
authors: Elisabetta
authors: E
authors: Giovannini
authors: Department of Nuclear Medicine, S. Andrea Hospital, La Spezia, Italy.
authors: Patrizia
authors: P
authors: Lazzeri
authors: Department of Nuclear Medicine, S. Andrea Hospital, La Spezia, Italy.
authors: Elisa
authors: E
authors: Borsò
authors: Institute of Radiology and Nuclear Medicine, Stadtspital Triemli, Zurich, Switzerland.
authors: Antonio
authors: A
authors: Mannironi
authors: Department of Internal and Experimental Medicine Magrassi - Lanzara, Second University of Naples Napoli, Naples, Italy.
authors: Luigi
authors: L
authors: Mansi
mesh_terms: D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006801:Humans; D000071058:Huntingtin Protein / Q000235:genetics; D006816:Huntington Disease / Q000000981:diagnostic imaging* / Q000235:genetics / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D057054:Molecular Imaging / Q000379:methods*; D009154:Mutation; D010641:Phenotype; D049268:Positron-Emission Tomography; D011237:Predictive Value of Tests; D011379:Prognosis
chemical_list: D005819:Genetic Markers; C086055:HTT protein, human; D000071058:Huntingtin Protein