title: Efficacy and Safety of Laser Surgery and Transurethral Resection of the Prostate for Treating Benign Prostate Hyperplasia: a Network Meta-analysis.
abstract: BACKGROUND
  Traditional meta-analyses or systematic reviews of randomized controlled trials (RCTs) have been used to compare laser surgeries and transurethral resection of the prostate (TURP) for benign prostate hyperplasia (BHP), but they cannot provide a hierarchy regarding efficacy and safety of treatment.
  
  
  OBJECTIVE
  We therefore performed a network meta-analysis (NMA) to compare and create hierarchies for efficacy and safety of TUPR and laser surgeries for BPH.
  
  
  METHODS
  We searched for reports of RCTs published up to April 25, 2015. After methodological quality assessment and data extraction, we performed an NMA to compare TURP and laser surgeries for BPH.
  
  
  RESULTS
  We ranked the treatments of TURP and laser surgeries for BPH. For IPSS at 6 months, holmium laser resection of the prostate (HoLRP) ranked the first-best and at 12 months, holmium laser enucleation of the prostate (HoLEP). For Qmax at 6 and 12 months, HoLEP ranked the first-best; for operative time it was TURP; for cathedral removal time, diode laser enucleation of the prostate (DiLEP) ranked the first-best.
  
  
  CONCLUSIONS
  Although TURP is considered the gold standard for treating BPH, it is not better in terms of efficacy and safety compared with the laser surgery. Our NMA created hierarchies for the 9 types of surgery in terms of efficacy and safety, which should help clinicians choose the best approach for the individual patient.
authors: Department of Preventive Medicine, Shantou University Medical College, Shantou, Guangdong, China E-mail : keli1122@126.com.
authors: Li
authors: L
authors: Wang
authors: Qiu-Yan
authors: QY
authors: Yu
authors: Yan
authors: Y
authors: Liu
authors: Zhen-Li
authors: ZL
authors: Zhu
authors: Yuan-Wei
authors: YW
authors: Huang
authors: Ke
authors: K
authors: Li
mesh_terms: D006801:Humans; D053685:Laser Therapy / Q000379:methods*; D008297:Male; D011183:Postoperative Complications; D011379:Prognosis; D011467:Prostate / Q000601:surgery*; D011468:Prostatectomy; D011470:Prostatic Hyperplasia / Q000601:surgery*; D020728:Transurethral Resection of Prostate / Q000379:methods*