title: Polymorphisms and expression of IL-32: impact on genetic susceptibility and clinical outcome of lung cancer.
abstract: BACKGROUND
  Polymorphisms of IL-32 related closely to tumoregenesis.
  
  
  METHODS
  Two IL-32 polymorphisms (rs12934561 and rs28372698) and mRNA expression were conducted by SNP genotype assay and real-time PCR in 423 lung cancer patients and 437 controls.
  
  
  RESULTS
  T allele of rs28372698 associated significantly with poor prognosis in moderate and well-differentiated lung cancer patients. TT genotype of rs12934561 related closely to poor survival status in squamous carcinoma. IL-32 mRNA expression decreased in lung cancer.
  
  
  CONCLUSIONS
  Our study indicates the importance of IL-32 polymorphism and mRNA expression in susceptibility and influence of survival status in lung cancer.
authors: a Laboratory of Pathology, Department of Pathology , West China Hospital Sichuan University , Chengdu , P.R. China.
authors: Yanwen
authors: Y
authors: Wang
authors: a Laboratory of Pathology, Department of Pathology , West China Hospital Sichuan University , Chengdu , P.R. China.
authors: Yongfeng
authors: Y
authors: Yang
authors: a Laboratory of Pathology, Department of Pathology , West China Hospital Sichuan University , Chengdu , P.R. China.
authors: Yihan
authors: Y
authors: Zhu
authors: a Laboratory of Pathology, Department of Pathology , West China Hospital Sichuan University , Chengdu , P.R. China.
authors: Li
authors: L
authors: Li
authors: a Laboratory of Pathology, Department of Pathology , West China Hospital Sichuan University , Chengdu , P.R. China.
authors: Fei
authors: F
authors: Chen
authors: a Laboratory of Pathology, Department of Pathology , West China Hospital Sichuan University , Chengdu , P.R. China.
authors: Li
authors: L
authors: Zhang
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000401:mortality; D016022:Case-Control Studies; D015870:Gene Expression; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007378:Interleukins / Q000235:genetics*; D008175:Lung Neoplasms / Q000235:genetics* / Q000401:mortality; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D012333:RNA, Messenger / Q000032:analysis
chemical_list: C496971:IL32 protein, human; D007378:Interleukins; D012333:RNA, Messenger
keywords: IL-32; lung cancer; prognosis; single-nucleotide polymorphism; survival status