title: Dibenzoyl-methane Derivatives as a Potential and Exciting New Therapy for the Treatment of Childhood Bone Cancer.
abstract: Childhood bone cancer though rare, has very limited treatment choices, with poor survival rates and often involving amputation. We developed a novel molecule, 2', 4'-dihydroxy-dithion-dibenzoyl-methane and tested it on hepatic, colon, lung and osteoblast cancer cell lines. Thionylation of 2', 4'- dihydroxydibenzoylmethane led to selective targeting of bone cancer cells, stopping their growth and leading to their death without affecting non-cancerous cells within the bone marrow or other non-malignant cells.
authors: School of Environment and Life Sciences, College of Science and Technology University of Salford, Manchester, U.K.
authors: Eman
authors: E
authors: Almelah
authors: School of Environment and Life Sciences, College of Science and Technology University of Salford, Manchester, U.K.
authors: David P T
authors: DP
authors: Smith
authors: School of Environment and Life Sciences, College of Science and Technology University of Salford, Manchester, U.K.
authors: Andrew
authors: A
authors: McGown
authors: School of Environment and Life Sciences, College of Science and Technology University of Salford, Manchester, U.K.
authors: Athar
authors: A
authors: Aziz
authors: Division of Chemistry & Environmental, Science Manchester Metropolitan University, Manchester, U.K.
authors: Herman J
authors: HJ
authors: Potgieter
authors: School of Environment and Life Sciences, College of Science and Technology University of Salford, Manchester, U.K. p.a.ragazzon@salford.ac.uk.
authors: Patricia
authors: P
authors: Ragazzon
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000188:drug therapy*; D045744:Cell Line, Tumor; D047188:Chalcones / Q000627:therapeutic use*; D002648:Child; D006801:Humans
chemical_list: D000970:Antineoplastic Agents; D047188:Chalcones; C061481:dibenzoylmethane
keywords: Bone cancer; childhood; dibenzoylmethane