title: Multifunctional Surface Modification: Facile and Flexible Reactivity toward a Precisely Controlled Biointerface.
abstract: A multicomponent functional polymer is synthesized to support specific reactivity for successful conjugation with the vast array of functionality present in biological systems and the flexibility to conjugate biomolecules without requiring additional modification to install a terminal functional group. The multifunctional surface is realized using a novel coating composed of distinct N-hydroxysuccinimide (NHS) ester and benzoyl functionalities, which can provide accessibility to both the NHS ester-amine coupling reaction and the photochemically induced benzophenone crosslinking reaction, respectively. In addition, the multifunctional polymer is fabricated and transformed to form nanoscale colloids through the solvent displacement of a water/DMF system due to solubility characteristics of the resulting polymer with high polarity. A facile and efficient fabrication approach using the multifunctional nanocolloid is thus demonstrated to create a drug carrier by installing paclitaxel and folic acid for targeted cancer therapy.
authors: Department of Chemical Engineering, National Taiwan University, Taipei, 10617, Taiwan.
authors: Ruei-Hung
authors: RH
authors: Yuan
authors: Department of Chemical Engineering, National Taiwan University, Taipei, 10617, Taiwan.
authors: Chih-Yu
authors: CY
authors: Wu
authors: Department of Chemical Engineering, National Taiwan University, Taipei, 10617, Taiwan.
authors: Hsing-Ying
authors: HY
authors: Tung
authors: Department of Chemical Engineering, National Taiwan University, Taipei, 10617, Taiwan.
authors: Hung-Pin
authors: HP
authors: Hsieh
authors: Department of Chemical Engineering, National Taiwan University, Taipei, 10617, Taiwan.
authors: Yi-Jye
authors: YJ
authors: Li
authors: Department of Dentistry, National Taiwan University Hospital, Taipei, 10048, Taiwan.
authors: Yu-Chih
authors: YC
authors: Chiang
authors: Department of Chemical Engineering, National Taiwan University, Taipei, 10617, Taiwan.
authors: Hsien-Yeh
authors: HY
authors: Chen
mesh_terms: D016475:3T3 Cells; D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D001672:Biocompatible Materials / Q000494:pharmacology*; D000067493:Dynamic Light Scattering; D005453:Fluorescence; D006367:HeLa Cells; D006801:Humans; D051379:Mice; D008855:Microscopy, Electron, Scanning; D017239:Paclitaxel / Q000494:pharmacology; D058105:Polymerization; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry; D013388:Succinimides / Q000737:chemistry; D013499:Surface Properties; D034421:Sus scrofa; D014992:Xylenes / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D011108:Polymers; D013388:Succinimides; D014992:Xylenes; C001426:N-hydroxysuccinimide; D017239:Paclitaxel
keywords: bioconjugation; biointerface; multifunctional; nanocolloid; poly-para-xylylene