title: A Decennium of Etiology and Antimicrobial Susceptibility Patterns in Patients with Infective Endocarditis at a University Hospital, Thailand.
abstract: Infective endocarditis is an infection with a high mortality rate. Antimicrobial therapy is important for treatment, but data on antimicrobial susceptibilities are limited. This retrospective study analyzed data on the causative microorganisms and antimicrobial susceptibility patterns in patients with infective endocarditis 18 years of age or older who received inpatient care between 2006 and 2015 at King Chulalongkorn Memorial Hospital. A total of 213 patients fulfilled the inclusion criteria. Streptococcus spp. (54.5%) was the most common organism. Viridans streptococcus (46%) was the leading pathogen, followed by Group B streptococcus (27%). The majority of Streptococcus spp. were susceptible to penicillin (82.7%). Among Streptococcus spp., Streptococcus suis had the highest MIC90of penicillin and cefotaxime (1.65 and 0.95 μg/ml, respectively). There was a statistically significant increase in the MICs of penicillin and cefotaxime for Streptococcus suis (P = 0.03 and 0.04). Only 45.5% of Streptococcus suis and 77.5% of Viridans streptococcus were susceptible to penicillin. All Enterococcus spp. and Staphylococcus spp. were susceptible to vancomycin. In conclusion, the prevalence of Group B streptococcus isolates increased among patients with infective endocarditis in Thailand. Streptococcus suis had the highest MIC90and proportion of isolates not susceptible to penicillin. Rigorous restriction of the use of antimicrobial agents in animal feeds should be a primary concern.
authors: College of Pharmacotherapy of Thailand.|Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Chulalongkorn University.
authors: Chotirat
authors: C
authors: Nakaranurack
authors: Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Chulalongkorn University.
authors: Chankit
authors: C
authors: Puttilerpong
authors: Division of Infectious Diseases, Faculty of Medicine, Chulalongkorn University, and the King Chulalongkorn Memorial Hospital, The Thai Red Cross Society Bangkok.
authors: Gompol
authors: G
authors: Suwanpimolkul
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000145:classification / Q000187:drug effects* / Q000302:isolation & purification*; D004697:Endocarditis, Bacterial / Q000453:epidemiology* / Q000382:microbiology*; D005260:Female; D005658:Fungi / Q000145:classification / Q000302:isolation & purification; D006785:Hospitals, University; D006801:Humans; D007297:Inpatients; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D012189:Retrospective Studies; D013785:Thailand / Q000453:epidemiology
chemical_list: D000900:Anti-Bacterial Agents
keywords: Thailand; antimicrobial susceptibility; etiology; infective endocarditis