title: A treatise on benzimidazole based Schiff base metal(II) complexes accentuating their biological efficacy: Spectroscopic evaluation of DNA interactions, DNA cleavage and antimicrobial screening.
abstract: Two novel imidazole derived Schiff bases, (Z)-1-(1H-benzo[d]imidazol-2-yl)-N-benzylidenemethanamine (L1) and 1-(1H-benzo[d]imidazol-2-yl)-N-(4-nitrobenzylidene) methanamine, and a series of their transition metal complexes of the types [M(L1)2]Cl2and [M(L2)2]Cl2where, M=Cu(II), Ni(II), Co(II) and Zn(II) have been designed and synthesized. These compounds were characterized by various spectral and physicochemical data. UV-Vis, magnetic susceptibility and molar conductivity data indicate that all the complexes adopt square planar geometry. The EPR spectral data of the Cu(II) complexes have provided supportive evidence to the conclusion derived on the basis of electronic absorption and magnetic moment values. Moreover, the interaction of complexes with DNA via intercalation has been explored by absorption, fluorescence spectroscopy, cyclic voltammetry, viscosity and circular dichroism. Agarose gel electrophoresis technique reveals that the complexes are good metallonucleases. All the compounds have relatively high antibacterial and antifungal potencies. Among the metal complexes, Cu(II) complexes exhibit higher efficacy against all the pathogens.
authors: Research Department of Chemistry, VHNSN College, Virudhunagar 626 001, Tamil Nadu, India.
authors: Ganesan
authors: G
authors: Kumaravel
authors: Research Department of Chemistry, VHNSN College, Virudhunagar 626 001, Tamil Nadu, India. Electronic address: ramchem1964@gmail.com.
authors: Natarajan
authors: N
authors: Raman
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D001562:Benzimidazoles / Q000737:chemistry*; D002942:Circular Dichroism; D056831:Coordination Complexes / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D053837:DNA Cleavage / Q000187:drug effects*; D004553:Electric Conductivity; D004563:Electrochemistry; D004578:Electron Spin Resonance Spectroscopy; D004587:Electrophoresis, Agar Gel; D008024:Ligands; D008280:Magnetics; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D066244:Proton Magnetic Resonance Spectroscopy; D012545:Schiff Bases / Q000737:chemistry*; D013050:Spectrometry, Fluorescence; D013055:Spectrophotometry, Infrared; D014783:Viscosity
chemical_list: D000900:Anti-Bacterial Agents; D001562:Benzimidazoles; D056831:Coordination Complexes; D008024:Ligands; D012545:Schiff Bases; D004247:DNA; C031000:benzimidazole
keywords: Antimicrobial activity; Benzimidazole derivatives; DNA helicity; Fluorescence; Intercalation