title: Serum dehydroepiandrosterone levels are associated with lower risk of type 2 diabetes: the Rotterdam Study.
abstract: Previous literature documents controversial results for the impact of dehydroepiandrosterone (DHEA) in glucose metabolism. We aimed to assess the associations between serum levels of DHEA and its main derivatives DHEA sulphate (DHEAS) and androstenedione, as well as the ratio of DHEAS to DHEA, and risk of type 2 diabetes.
  
  
  
  We used data on serum levels of DHEA, DHEAS and androstenedione from 5189 middle-aged and elderly men and women from the prospective population-based Rotterdam Study. Type 2 diabetes was defined as a fasting blood glucose ≥7.0 mmol/l or a non-fasting blood glucose ≥11.1 mmol/l.
  
  
  
  During a median follow-up of 10.9 years, 643 patients with incident type 2 diabetes were identified. After adjusting for age, sex, cohort, fasting status, fasting glucose and insulin, and BMI, both serum DHEA levels (per 1 unit natural log-transformed, HR 0.76, 95% CI 0.67, 0.87) and serum DHEAS levels (per 1 unit natural log-transformed, HR 0.82, 95% CI 0.73, 0.92) were inversely associated with risk of type 2 diabetes in the total population. Further adjustment for alcohol, smoking, physical activity, prevalent cardiovascular disease, serum total cholesterol, use of lipid-lowering medications, systolic BP, treatment for hypertension, C-reactive protein, oestradiol and testosterone did not substantially affect the association between DHEA and incident type 2 diabetes (per 1 unit natural log-transformed, HR 0.80, 95% CI 0.65, 0.99), but abolished the association between DHEAS and type 2 diabetes. Androstenedione was not associated with risk of type 2 diabetes, nor was DHEAS to DHEA ratio.
  
  
  
  DHEA serum levels might be an independent marker of type 2 diabetes.
authors: Department of Epidemiology, Erasmus University Medical Center, PO Box 2040, 3000 CA, Rotterdam, the Netherlands. a.brahimaj@erasmusmc.nl.
authors: Adela
authors: A
authors: Brahimaj
authors: Department of Epidemiology, Erasmus University Medical Center, PO Box 2040, 3000 CA, Rotterdam, the Netherlands.
authors: Taulant
authors: T
authors: Muka
authors: Department of Epidemiology, Erasmus University Medical Center, PO Box 2040, 3000 CA, Rotterdam, the Netherlands.
authors: Maryam
authors: M
authors: Kavousi
authors: Division of Reproductive Medicine, Department of Obstetrics and Gynaecology, Erasmus MC, Rotterdam, the Netherlands.
authors: Joop S E
authors: JS
authors: Laven
authors: Department of Epidemiology, Erasmus University Medical Center, PO Box 2040, 3000 CA, Rotterdam, the Netherlands.
authors: Abbas
authors: A
authors: Dehghan
authors: Department of Epidemiology, Erasmus University Medical Center, PO Box 2040, 3000 CA, Rotterdam, the Netherlands.
authors: Oscar H
authors: OH
authors: Franco
mesh_terms: D000368:Aged; D000735:Androstenedione / Q000097:blood; D015331:Cohort Studies; D003687:Dehydroepiandrosterone / Q000097:blood*; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000453:epidemiology* / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism; D013739:Testosterone / Q000097:blood
chemical_list: D012738:Sex Hormone-Binding Globulin; D013739:Testosterone; D000735:Androstenedione; D003687:Dehydroepiandrosterone; D019314:Dehydroepiandrosterone Sulfate
keywords: Androstenedione; DHEA; DHEAS; Food supplement; Independent marker; Type 2 diabetes