title: The schizophrenia susceptibility gene ZNF804A confers risk of major mood disorders.
abstract: Genome-wide association studies (GWAS) followed by independent replications suggest that ZNF804A is a risk gene for schizophrenia (SCZ), considering the substantial genetic overlap between SCZ and major mood disorders (e.g., bipolar disorder (BPD) and major depressive disorder (MDD)).
  
  
  
  We collected the data of two ZNF804A single-nucleotide polymorphisms (SNPs rs1344706 and rs7597593) from European and Asian populations to perform systematic meta-analyses with major mood disorders in a total of 65,240 subjects.
  
  
  
  Meta-analysis showed that rs1344706 and rs7597593 were both associated with major mood disorders as well as diagnosis of either BPD or MDD, although neither of the analyses achieved a genome-wide level of statistical significance.
  
  
  
  Our data provide evidence for the genetic involvement of ZNF804A SNPs in the susceptibility of major mood disorders, but further replication analyses in larger samples are necessary.
authors: a Mental Health Institute of the Second Xiangya Hospital, Central South University , Changsha , Hunan , China.
authors: Jianjun
authors: J
authors: Ou
authors: b Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province , Kunming Institute of Zoology , Kunming , Yunnan , China.
authors: Ming
authors: 0000-0002-8197-6552
authors: M
authors: Li
authors: b Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province , Kunming Institute of Zoology , Kunming , Yunnan , China.
authors: Xiao
authors: X
authors: Xiao
mesh_terms: D001714:Bipolar Disorder / Q000235:genetics*; D003865:Major Depressive Disorder / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D051741:Kruppel-Like Transcription Factors / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*
chemical_list: D051741:Kruppel-Like Transcription Factors; C540527:ZNF804A protein, human
keywords: GWAS; ZNF804A; bipolar disorder; major depressive disorder; schizophrenia