title: [Clinic of humoral primary immunodeficiencies in adults. Experience in a tertiary hospital].
abstract: Primary immunodeficiencies (PID) are characterized by alteration of the components of the immune system. Humoral deficiencies represent 50%. The most common are selective IgA deficiency, Bruton agammaglobulinemia, and common variable immunodeficiency (CVID).
  
  
  
  To describe the epidemiological and clinical characteristics of adults with humoral PID, cared for in a Primary Humoral Immunodeficiencies Clinic.
  
  
  
  A descriptive cross-sectional study that included a year of analysis, including 35 patients with humoral PID, 31 with CVID, and 4 with Bruton agammaglobulinemia. Data were analyzed with descriptive statistics.
  
  
  
  Of 35 patients studied, 31 had CVID (88.5%) and 4 (11.5%) Bruton agammaglobulinemia; 21 were men and 14 women. The age at onset of symptoms was 22.7 years, and the delay in diagnosis was 7.2 years. 11.4% of CVID patients died during the study; 4 had malignancies, 22.8% autoimmune diseases, and 48.5% gastrointestinal disorders. Patients with Bruton agammaglobulinemia presented no comorbidities.
  
  
  
  Unlike reports in the literature, in the study group, CVID was the most common cause of humoral PID, predominantly in men; the most common gastrointestinal disorder was intestinal functional disorder.
authors: Instituto Mexicano del Seguro Social, Centro Médico Nacional Siglo XXI, Hospital de Especialidades, Servicio de Alergia e Inmunología Clínica, Ciudad de México, México. jcesar_963@hotmail.com.
authors: Julio César
authors: JC
authors: Cambray-Gutiérrez
authors: Diana Andrea
authors: DA
authors: Herrera-Sánchez
authors: Lizbeth
authors: L
authors: Blancas-Galicia
authors: Patricia María
authors: PM
authors: O'Farrill-Romanillos
mesh_terms: D000328:Adult; D000361:Agammaglobulinemia / Q000453:epidemiology*; D017668:Age of Onset; D017074:Common Variable Immunodeficiency / Q000453:epidemiology*; D003430:Cross-Sectional Studies; D005260:Female; D040181:Genetic Diseases, X-Linked / Q000453:epidemiology*; D006801:Humans; D008297:Male; D012737:Sex Factors; D062606:Tertiary Care Centers / Q000706:statistics & numerical data; D055815:Young Adult
keywords: Bruton agammaglobulinemia; Common variable immunodeficiency; Humoral immunodeficiencies; Primary immunodeficiencies