title: Detection of viruses in weekly stool specimens collected during the first 2 years of life: A pilot study of five healthy Australian infants in the rotavirus vaccine era.
abstract: Several viruses are associated with gastroenteritis in infants. This pilot study, nested within a larger community-based project of early childhood infections, collected daily symptom data and 511 weekly stool samples from five healthy, fully vaccinated, term infants from birth until their second birthday. Real-time PCR assays were used to detect six enteric viruses. Frequent, silent shedding of one or more of the six viruses was observed, particularly involving adenovirus where shedding could be for up to 3 months without gastrointestinal symptoms. These pilot data demonstrate that a positive PCR result for enteric viruses may not always indicate the cause of childhood gastroenteritis. J. Med. Virol. 89:917-921, 2017. © 2016 Wiley Periodicals, Inc.
authors: University of Queensland Centre for Clinical Research, The University of Queensland, Brisbane, Queensland, Australia.|Division of Microbiology, Pathology Queensland Central Laboratory, Brisbane, Queensland, Australia.|UQ Child Health Research Centre, The University of Queensland, Brisbane, Queensland, Australia.
authors: Suifang
authors: S
authors: Ye
authors: University of Queensland Centre for Clinical Research, The University of Queensland, Brisbane, Queensland, Australia.|Division of Microbiology, Pathology Queensland Central Laboratory, Brisbane, Queensland, Australia.
authors: David M
authors: DM
authors: Whiley
authors: UQ Child Health Research Centre, The University of Queensland, Brisbane, Queensland, Australia.|School of Public Health, The University of Queensland, Brisbane, Queensland, Australia.
authors: Robert S
authors: RS
authors: Ware
authors: UQ Child Health Research Centre, The University of Queensland, Brisbane, Queensland, Australia.
authors: Theo P
authors: TP
authors: Sloots
authors: Murdoch Childrens Research Institute, Melbourne, Victoria, Australia.|Enteric and Diarrheal Diseases, Global Health, Bill and Melinda Gates Foundation, Seattle, Washington.
authors: Carl D
authors: CD
authors: Kirkwood
authors: UQ Child Health Research Centre, The University of Queensland, Brisbane, Queensland, Australia.|Menzies Health Institute Queensland, Griffith University and Gold Coast Health, Gold Coast, Queensland, Australia.
authors: Keith
authors: K
authors: Grimwood
authors: UQ Child Health Research Centre, The University of Queensland, Brisbane, Queensland, Australia.
authors: Stephen B
authors: SB
authors: Lambert
mesh_terms: D001315:Australia / Q000453:epidemiology; D005243:Feces / Q000821:virology*; D064368:Healthy Volunteers; D006801:Humans; D007223:Infant; D008137:Longitudinal Studies; D011446:Prospective Studies; D060888:Real-Time Polymerase Chain Reaction; D014777:Virus Diseases / Q000453:epidemiology* / Q000821:virology*; D017201:Virus Shedding; D014780:Viruses / Q000145:classification* / Q000302:isolation & purification*