title: Transcatheter arterial embolization with ethylene vinyl alcohol copolymer (Onyx) for the treatment of hemorrhage due to uterine arteriovenous malformations.
abstract: OBJECTIVE
  The purpose of this study was to evaluate the effectiveness of ethylene vinyl alcohol copolymer (Onyx) as a single embolic agent for percutaneous arterial treatment of hemorrhage due to uterine arteriovenous malformations (AVMs).
  
  
  METHODS
  Twelve women (mean age, 33 years) with metrorrhagia due to uterine AVMs who were treated by percutaneous arterial embolization using Onyx as a single embolic agent were retrospectively included. The diagnosis of uterine AVM was suggested by pelvic ultrasound and/or magnetic resonance imaging findings and further confirmed by angiography. Clinical files and angiographic examinations were reviewed for angiographic findings, technical and clinical success, procedure complication and further pregnancies. Clinical success was defined by absence of metrorrhagia at 1 month following embolization.
  
  
  RESULTS
  Sixteen arterial embolization procedures were performed. Angiographically, 6 women had high flow AVM and 6 had low flow AVM. The rate of technical and clinical success was 92% (11/12 patients). One woman with early repeat hemorrhage underwent two embolization procedures and further hysterectomy. No severe complications were observed after embolization. Three women (3/12; 25%) became pregnant following embolization including one full term pregnancy.
  
  
  CONCLUSIONS
  In women with metrorrhagia due to AVM, arterial embolization with Onyx is effective and safe. Additional research is needed to confirm the possibility of future pregnancy after Onyx embolization.
authors: Department of radiology, hôpital de la Timone, 264, rue Saint-Pierre, 13385 Marseille cedex 05, France. Electronic address: Pierre-Antoine.BARRAL@ap-hm.fr.
authors: P-A
authors: PA
authors: Barral
authors: Department of radiology, centre hospitalier régional universitaire de Lille, 2, avenue Oscar-Lambret, 59000 Lille, France.
authors: M
authors: M
authors: Saeed-Kilani
authors: Department of radiology, hôpital de la Timone, 264, rue Saint-Pierre, 13385 Marseille cedex 05, France.
authors: F
authors: F
authors: Tradi
authors: Department of radiology, hôpital de la Timone, 264, rue Saint-Pierre, 13385 Marseille cedex 05, France.
authors: A
authors: A
authors: Dabadie
authors: Department of radiology, hôpital de la Timone, 264, rue Saint-Pierre, 13385 Marseille cedex 05, France.
authors: J
authors: J
authors: Izaaryene
authors: Department of radiology, hôpital Nord, chemin des Bourelly, 13015 Marseille, France.
authors: J
authors: J
authors: Soussan
authors: Department of radiology, hôpital de la Timone, 264, rue Saint-Pierre, 13385 Marseille cedex 05, France.
authors: J-M
authors: JM
authors: Bartoli
authors: Department of radiology, hôpital de la Timone, 264, rue Saint-Pierre, 13385 Marseille cedex 05, France.
authors: V
authors: V
authors: Vidal
mesh_terms: D000328:Adult; D001165:Arteriovenous Malformations / Q000150:complications*; D002404:Catheterization; D004621:Embolization, Therapeutic / Q000379:methods*; D005260:Female; D006470:Hemorrhage / Q000209:etiology* / Q000628:therapy*; D006801:Humans; D008875:Middle Aged; D011145:Polyvinyls / Q000008:administration & dosage*; D012189:Retrospective Studies; D014599:Uterus / Q000098:blood supply*; D014656:Vascular Surgical Procedures; D055815:Young Adult
chemical_list: D011145:Polyvinyls; C020320:ethylene-vinyl alcohol copolymer
keywords: Uterine arteriovenous malformations; Uterine artery embolization; Uterine hemorrhage; Uterus