title: The Long and Complicated Relationship between Epstein-Barr Virus and Epithelial Cells.
abstract: The roles of epithelial cells in infection and persistence of the Epstein-Barr virus (EBV) have long been difficult to resolve. However, recent developments have reinforced the conclusion that these cells are a major site of virus replication and raised the possibility that, like papillomaviruses, EBV has evolved to take advantage of epithelial differentiation to ensure survival, persistence, and spread.
authors: Department of Microbiology and Immunology, Center for Molecular and Tumor Virology, Feist-Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, Louisiana, USA lhuttf@lsuhsc.edu.
authors: Lindsey M
authors: LM
authors: Hutt-Fletcher
mesh_terms: D001402:B-Lymphocytes / Q000276:immunology / Q000821:virology*; D002454:Cell Differentiation; D004847:Epithelial Cells / Q000276:immunology / Q000821:virology*; D020031:Epstein-Barr Virus Infections / Q000235:genetics / Q000276:immunology / Q000635:transmission / Q000821:virology*; D015967:Gene Expression Regulation, Viral / Q000276:immunology*; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000276:immunology*; D054884:Host-Pathogen Interactions; D006801:Humans; D017874:Immediate-Early Proteins / Q000235:genetics / Q000276:immunology; D007156:Immunologic Memory; D015398:Signal Transduction; D015534:Trans-Activators / Q000235:genetics / Q000276:immunology; D056189:Viral Tropism / Q000235:genetics / Q000276:immunology; D017735:Virus Latency / Q000235:genetics / Q000276:immunology; D014779:Virus Replication / Q000235:genetics / Q000276:immunology
chemical_list: C068382:BRLF1 protein, Human herpesvirus 4; C063676:BZLF1 protein, Herpesvirus 4, Human; D017874:Immediate-Early Proteins; D015534:Trans-Activators
keywords: Epstein-Barr virus; epithelial cells; tropism