title: [Comparative proteome analysis of blood plasma of patients with early-stage chronic cerebral ischemia].
abstract: In the present study, we explored the technology of liquid chromatography-mass spectrometry (HPLC-MS/MS) for the proteome analysis of blood plasma of patients with early chronic cerebral ischemia. Analysis of mass-spectrometer data carried out in automatic mode using the software Progenesis LS-MS. As a result of this study identified 43 proteins. The differences identified in the study group compared with the control in 7 proteins. It was found that in the early stages of chronic cerebral ischemia proteome changes in blood plasma affect proteins related to the immune system, the system for the maintenance of hemostasis and lipid metabolism.
authors: Institute of Biomedical Chemistry, Moscow, Russia.
authors: Y S
authors: YS
authors: Kisrieva
authors: Institute of Biomedical Chemistry, Moscow, Russia.
authors: N A
authors: NA
authors: Petushkova
authors: Institute of Biomedical Chemistry, Moscow, Russia.
authors: N F
authors: NF
authors: Samenkova
authors: Institute of Biomedical Chemistry, Moscow, Russia.
authors: G P
authors: GP
authors: Kuznetsova
authors: Institute of Biomedical Chemistry, Moscow, Russia.
authors: O V
authors: OV
authors: Larina
authors: Institute of Biomedical Chemistry, Moscow, Russia.
authors: M G
authors: MG
authors: Zavialova
authors: Burdenko Institute of Neurosurgery, Moscow, Russia.
authors: N B
authors: NB
authors: Teryaeva
authors: Burdenko Institute of Neurosurgery, Moscow, Russia.
authors: A Y
authors: AY
authors: Belyaev
authors: Institute of Biomedical Chemistry, Moscow, Russia.
authors: I I
authors: II
authors: Karuzina
mesh_terms: D001798:Blood Proteins / Q000378:metabolism*; D002545:Brain Ischemia / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D020543:Proteome / Q000378:metabolism*; D040901:Proteomics / Q000379:methods*
chemical_list: D001798:Blood Proteins; D020543:Proteome
keywords: Liquid Chromatography and Mass Spectrometry; Orbitrap; blood plasma proteome; cerebral ischemia