title: Platelet-Rich Plasma.
abstract: Platelet-rich plasma (PRP) is a growing and robust therapeutic option in musculoskeletal medicine. PRP is a preparation of autologous plasma enriched with a platelet concentration above that normally contained in whole blood. The rationale for use and therapeutic potential of a high concentration of platelets is based on their capacity to supply supraphysiologic amounts of essential growth factors to provide a regenerative stimulus that promotes repair in tissues with low healing potential. This article reviews the latest basic science on PRP, clinical evidence for its use in musculoskeletal medicine, limitations in current knowledge, and critical areas for future research.
authors: Department of Physical Medicine & Rehabilitation, Spaulding Rehabilitation Hospital, Harvard Medical School, 300 First Avenue, Charlestown, MA 02129, USA. Electronic address: iwu3@partners.org.
authors: Peter I-Kung
authors: PI
authors: Wu
authors: Department of Physical Medicine & Rehabilitation, Spaulding Rehabilitation Hospital, Harvard Medical School, 300 First Avenue, Charlestown, MA 02129, USA.
authors: Robert
authors: R
authors: Diaz
authors: Department of Physical Medicine & Rehabilitation, Newton-Wellesley Hospital Spine Center, Spaulding Rehabilitation Hospital, Harvard Medical School, 65 Walnut Street, Wellesley, MA 02481, USA.
authors: Joanne
authors: J
authors: Borg-Stein
mesh_terms: D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000502:physiology*; D009140:Musculoskeletal Diseases / Q000628:therapy*; D053657:Platelet-Rich Plasma
chemical_list: D036341:Intercellular Signaling Peptides and Proteins
keywords: Healing; Injection; Musculoskeletal; Platelet-rich plasma; Regenerative; Rehabilitation; Sports