title: NADPH oxidases and vascular remodeling in cardiovascular diseases.
abstract: Reactive oxygen species (ROS) are key signaling molecules that regulate vascular function and structure in physiological conditions. A misbalance between the production and detoxification of ROS increases oxidative stress that is involved in the vascular remodeling associated with cardiovascular diseases such as hypertension by affecting inflammation, hypertrophy, migration, growth/apoptosis and extracellular matrix protein turnover. The major and more specific source of ROS in the cardiovascular system is the NADPH oxidase (NOX) family of enzymes composed of seven members (NOX1-5, DUOX 1/2). Vascular cells express several NOXs being NOX-1 and NOX-4 the most abundant NOXs present in vascular smooth muscle cells. This review focuses on specific aspects of NOX-1 and NOX-4 isoforms including information on regulation, function and their role in vascular remodeling. In order to obtain a more integrated view about the role of the different NOX isoforms in different types of vascular remodeling, we discuss the available literature not only on hypertension but also in atherosclerosis, restenosis and aortic dilation.
authors: Departamento de Farmacología, Facultad de Medicina, Universidad Autónoma de Madrid, Instituto de Investigación Hospital Universitario La Paz (IdiPAZ), 28029, Madrid, Spain.
authors: Ana B
authors: AB
authors: García-Redondo
authors: Departamento de Farmacología, Facultad de Medicina, Universidad Autónoma de Madrid, Instituto de Investigación Hospital Universitario La Paz (IdiPAZ), 28029, Madrid, Spain.
authors: Andrea
authors: A
authors: Aguado
authors: Departamento de Farmacología, Facultad de Medicina, Universidad Autónoma de Madrid, Instituto de Investigación Hospital Universitario La Paz (IdiPAZ), 28029, Madrid, Spain. Electronic address: ana.briones@uam.es.
authors: Ana M
authors: AM
authors: Briones
authors: Departamento de Farmacología, Facultad de Medicina, Universidad Autónoma de Madrid, Instituto de Investigación Hospital Universitario La Paz (IdiPAZ), 28029, Madrid, Spain. Electronic address: mercedes.salaices@uam.es.
authors: Mercedes
authors: M
authors: Salaices
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000201:enzymology* / Q000378:metabolism / Q000473:pathology*; D002465:Cell Movement; D049109:Cell Proliferation; D006801:Humans; D000074624:NADPH Oxidase 1 / Q000032:analysis / Q000378:metabolism; D000074663:NADPH Oxidase 4 / Q000032:analysis / Q000378:metabolism; D019255:NADPH Oxidases / Q000032:analysis / Q000378:metabolism*; D020033:Protein Isoforms / Q000032:analysis / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism; D066253:Vascular Remodeling
chemical_list: D020033:Protein Isoforms; D017382:Reactive Oxygen Species; D000074624:NADPH Oxidase 1; D000074663:NADPH Oxidase 4; D019255:NADPH Oxidases
keywords: Cardiovascular diseases; Cell migration; Cell proliferation; NOX-1; NOX-4; Reactive oxygen species; Vascular remodeling; Vascular smooth muscle cells