title: Orthobiologics and Knee Osteoarthritis: A Recent Literature Review, Treatment Algorithm, and Pathophysiology Discussion.
abstract: This article reviews the current options in orthobiologics for the clinical treatment of knee osteoarthritis (OA). We describe a new model of knee OA that fills the gap in our understanding of it as a purely traumatic and/or inflammation-induced cartilage degenerative condition, to a current model of multinodal pathophysiology. We discuss graft choice and patient selection in the current state of understanding of the treatment of knee OA in a tissue engineering model with orthobiologics. We present a sample treatment algorithm and decision nest for deciding how to proceed with patient care.
authors: Bluetail Medical Group, St Louis, MO, USA; Bluetail Medical Group, Naples, FL, USA; 17300 North Outer 40 Drive, Suite 201, Chesterfield, MO 63005, USA. Electronic address: Dcranemd@gmail.com.
authors: David M
authors: DM
authors: Crane
authors: Bluetail Medical Group, St Louis, MO, USA; Bluetail Medical Group, Naples, FL, USA; 17300 North Outer 40 Drive, Suite 201, Chesterfield, MO 63005, USA; Bluetail Medical Group, Columbia, MO, USA.
authors: Kristin S
authors: KS
authors: Oliver
authors: Bluetail Medical Group, St Louis, MO, USA; 17300 North Outer 40 Drive, Suite 201, Chesterfield, MO 63005, USA.
authors: Matthew C
authors: MC
authors: Bayes
mesh_terms: D000465:Algorithms; D006801:Humans; D020370:Osteoarthritis, Knee / Q000503:physiopathology / Q000628:therapy*; D018579:Patient Selection
keywords: Extrusion; Fat lipoaspirate; Knee osteoarthritis; Meniscus; Multinodal pathophysiology; Orthobiologics; Stem cell depletion model; Tissue engineering