title: Acquired resistance to anti-PD1 therapy: checkmate to checkpoint blockade?
abstract: Anti-programmed cell death 1 (PD1) immunotherapies are among the most effective anti-cancer immunotherapies available; however, a large number of patients present with or develop resistance to them. Unfortunately, very little is known regarding the mechanisms of resistance to such therapies. A recent study sought to identify mutations associated with resistance to anti-PD1 therapy. Results from this study demonstrated that mutations which affected the sensitivity of tumor cells to T-cell-derived interferons, and mutations limiting tumor-cell antigen presentation, could cause acquired resistance. These findings have significant implications for understanding the mechanisms by which anti-PD1 therapies exert their efficacy, comprehending why and how some patients acquire resistance over time, and ultimately guiding the development of combination therapies designed to overcome, or potentially prevent, the development of acquired immunotherapeutic resistance.
authors: Immunology in Cancer and Infection Laboratory, QIMR Berghofer Medical Research Institute, Herston, 4006, QLD, Australia.|Cancer Immunoregulation and Immunotherapy Laboratory, QIMR Berghofer Medical Research Institute, Herston, 4006, QLD, Australia.|School of Medicine, The University of Queensland, Herston, 4006, QLD, Australia.
authors: Jake S
authors: JS
authors: O'Donnell
authors: Immunology in Cancer and Infection Laboratory, QIMR Berghofer Medical Research Institute, Herston, 4006, QLD, Australia.|School of Medicine, The University of Queensland, Herston, 4006, QLD, Australia.
authors: Mark J
authors: MJ
authors: Smyth
authors: Cancer Immunoregulation and Immunotherapy Laboratory, QIMR Berghofer Medical Research Institute, Herston, 4006, QLD, Australia. michele.teng@qimrberghofer.edu.au.|School of Medicine, The University of Queensland, Herston, 4006, QLD, Australia. michele.teng@qimrberghofer.edu.au.
authors: Michele W L
authors: MW
authors: Teng
mesh_terms: D000911:Antibodies, Monoclonal; D060890:B7-H1 Antigen / Q000276:immunology; D045744:Cell Line, Tumor; D006801:Humans; D007167:Immunotherapy; D058990:Molecular Targeted Therapy; D009154:Mutation; D009369:Neoplasms; D061026:Programmed Cell Death 1 Receptor / Q000276:immunology*; D013601:T-Lymphocytes
chemical_list: D000911:Antibodies, Monoclonal; D060890:B7-H1 Antigen; D061026:Programmed Cell Death 1 Receptor