title: Accurate Prediction of One-Dimensional Protein Structure Features Using SPINE-X.
abstract: Accurate prediction of protein secondary structure and other one-dimensional structure features is essential for accurate sequence alignment, three-dimensional structure modeling, and function prediction. SPINE-X is a software package to predict secondary structure as well as accessible surface area and dihedral angles ϕ and ψ. For secondary structure SPINE-X achieves an accuracy of between 81 and 84 % depending on the dataset and choice of tests. The Pearson correlation coefficient for accessible surface area prediction is 0.75 and the mean absolute error from the ϕ and ψ dihedral angles are 20∘and 33∘, respectively. The source code and a Linux executables for SPINE-X are available from Research and Information Systems at http://mamiris.com .
authors: Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, 46032, USA.|Research and Information Systems, LLC, Indianapolis, IN, USA.
authors: Eshel
authors: E
authors: Faraggi
authors: Battelle Center for Mathematical Medicine, Nationwide Children's Hospital, Columbus, OH, USA.|Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH, USA.
authors: Andrzej
authors: A
authors: Kloczkowski
mesh_terms: D000465:Algorithms; D000596:Amino Acids / Q000737:chemistry; D017433:Protein Structure, Secondary; D011506:Proteins / Q000737:chemistry* / Q000235:genetics; D016415:Sequence Alignment / Q000379:methods*; D012984:Software; D012997:Solvents / Q000737:chemistry
chemical_list: D000596:Amino Acids; D011506:Proteins; D012997:Solvents
keywords: Accessible surface area; Dihedral angles; Protein structure; Secondary structure