title: Brucella abortus S19 vaccine protects dairy cattle against natural infection with Brucella melitensis.
abstract: Brucellosis is a zoonotic disease that can cause severe illness in humans and considerable economic loss in the livestock industry. Although small ruminants are the preferential host for Brucella melitensis, this pathogen has emerged as a cause for Brucella outbreaks in cattle. S19 vaccination is implemented in many countries where B. abortus is endemic but its effectiveness against B. melitensis has not been validated. Here we show that vaccine effectiveness in preventing disease transmission between vaccinated and unvaccinated cohorts, as determined by seroconversion, was 87.2% (95% CI 69.5-94.6%). Furthermore, vaccination was associated with a reduced risk for abortion. Together, our data emphasize the role S19 vaccination could play in preventing B. melitensis outbreaks in areas where this pathogen is prevalent in small ruminant populations.
authors: "Hachaklait", Mutual Society for Veterinary Services, P.O.B. 3039, Caesarea Industrial Park, 38900, Israel. Electronic address: vanstraten@hachaklait.co.il.
authors: Michael
authors: M
authors: van Straten
authors: Kimron Veterinary Institute, P.O.B. 12, Bet Dagan 502501, Israel.
authors: Svetlana
authors: S
authors: Bardenstein
authors: "Hachaklait", Mutual Society for Veterinary Services, P.O.B. 3039, Caesarea Industrial Park, 38900, Israel.
authors: Gaby
authors: G
authors: Keningswald
authors: Kimron Veterinary Institute, P.O.B. 12, Bet Dagan 502501, Israel.
authors: Menachem
authors: M
authors: Banai
mesh_terms: D000034:Abortion, Veterinary / Q000382:microbiology / Q000517:prevention & control*; D000818:Animals; D000907:Antibodies, Bacterial; D002004:Brucella Vaccine / Q000008:administration & dosage* / Q000276:immunology; D002003:Brucella abortus / Q000276:immunology; D017347:Brucella melitensis / Q000276:immunology* / Q000472:pathogenicity; D002007:Brucellosis, Bovine / Q000517:prevention & control* / Q000635:transmission; D002417:Cattle; D056738:Cross Protection; D005260:Female; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000517:prevention & control / Q000662:veterinary; D000069078:Seroconversion; D014611:Vaccination / Q000662:veterinary
chemical_list: D000907:Antibodies, Bacterial; D002004:Brucella Vaccine
keywords: Brucella abortus; Brucella melitensis; Cattle; Cross protection; Vaccines