title: Cherenkov light production from the α-emitting decay chains of223Ra,212Pb, and149Tb for Cherenkov Luminescence Imaging.
abstract: Cherenkov Luminescence Imaging (CLI) is a new method to image radioactive therapeutic and diagnostic agents, primarily in preclinical studies. This study used Geant4 and Python to generate the predicted Cherenkov light production as a function of time for a set of isotopic chains of interest for targeted alpha therapy:223Ra,212Pb, and149Tb. All are shown to produce substantial Cherenkov light, though time delays between initial decays and the production of Cherenkov light requires caution in interpreting CLI.
authors: Department of Physics and Astronomy, Agnes Scott College, 141 E College Ave, Decatur, GA, 30030 United States.
authors: V
authors: V
authors: Wood
authors: Department of Physics and Astronomy, Agnes Scott College, 141 E College Ave, Decatur, GA, 30030 United States. Electronic address: nackerman@agnesscott.edu.
authors: N L
authors: NL
authors: Ackerman
mesh_terms: D000512:Alpha Particles; D003198:Computer Simulation; D007856:Lead Radioisotopes / Q000737:chemistry*; D008027:Light; D008163:Luminescent Measurements / Q000379:methods*; D008956:Models, Chemical; D011883:Radium / Q000737:chemistry*; D013725:Terbium / Q000737:chemistry*
chemical_list: D007856:Lead Radioisotopes; D013725:Terbium; C000615150:Radium-223; D011883:Radium
keywords: Cherenkov imaging; Lead-212; Radium-223; Terbium-149