title: Therapeutic and pathological roles of fibroblast growth factors in pulmonary diseases.
abstract: Fibroblast growth factors (FGFs) constitute a large family of polypeptides that are involved in many biological processes, ranging from prenatal cell-fate specification and organogenesis to hormonal and metabolic regulation in postnatal life. During embryonic development, these growth factors are important mediators of the crosstalk among ectoderm-, mesoderm-, and endoderm-derived cells, and they instruct the spatial and temporal growth of organs and tissues such as the brain, bone, lung, gut, and others. The involvement of FGFs in postnatal lung homeostasis is a growing field, and there is emerging literature about their roles in lung pathophysiology. In this review, the involvement of FGF signaling in a wide array of lung diseases will be summarized. Developmental Dynamics 246:235-244, 2017. © 2016 Wiley Periodicals, Inc.
authors: Excellence Cluster Cardio-Pulmonary System (ECCPS), member of the German Center for Lung Research (DZL), Universities of Giessen and Marburg Lung Center (UGMLC), Justus-Liebig-University Giessen, Giessen, Germany.
authors: Elie
authors: 0000-0001-7504-3417
authors: E
authors: El Agha
authors: Excellence Cluster Cardio-Pulmonary System (ECCPS), member of the German Center for Lung Research (DZL), Universities of Giessen and Marburg Lung Center (UGMLC), Justus-Liebig-University Giessen, Giessen, Germany.|Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.
authors: Werner
authors: W
authors: Seeger
authors: Excellence Cluster Cardio-Pulmonary System (ECCPS), member of the German Center for Lung Research (DZL), Universities of Giessen and Marburg Lung Center (UGMLC), Justus-Liebig-University Giessen, Giessen, Germany.|College of Life and Environmental Sciences, Wenzhou University, Wenzhou, China.
authors: Saverio
authors: S
authors: Bellusci
mesh_terms: D000818:Animals; D005346:Fibroblast Growth Factors / Q000502:physiology*; D006801:Humans; D008168:Lung / Q000196:embryology / Q000254:growth & development; D008171:Lung Diseases / Q000378:metabolism*; D038081:Organogenesis; D015398:Signal Transduction
chemical_list: D005346:Fibroblast Growth Factors
keywords: FGF; development; lung diseases