title: ZIP restores estrogen receptor expression and response to Tamoxifen in estrogen receptor negative tumors.
abstract: As a component of NURD histone deacetylase complex, ZIP serves as a tumor suppressor gene in the development of breast tumors. However, whether it takes part in chemotherapy resistance remains poorly defined. In the present study, we reported that ZIP enhanced the response to SERM chemotherapy in ER-negative cells. Overexpression of ZIP suppressed EGFR expression level and restored ERalpha protein level in cells resistant to Tamoxifen. In vivo data confirmed those in vitro findings.
authors: School of Life Science, Lanzhou University, Lanzhou, Gansu, 73000, PR China.
authors: Ning
authors: N
authors: Zhu
authors: State Key Laboratory of Veterinary Etiological Biology, National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agriculture Science, Lanzhou, Gansu, 73000, PR China.
authors: Jing
authors: J
authors: Zhang
authors: State Key Laboratory of Veterinary Etiological Biology, National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agriculture Science, Lanzhou, Gansu, 73000, PR China.
authors: Xiaodong
authors: X
authors: Qin
authors: School of Life Science, Lanzhou University, Lanzhou, Gansu, 73000, PR China.
authors: Ruidong
authors: R
authors: Miao
authors: School of Life Science, Lanzhou University, Lanzhou, Gansu, 73000, PR China.
authors: Yuping
authors: Y
authors: Du
authors: School of Life Science, Lanzhou University, Lanzhou, Gansu, 73000, PR China. Electronic address: yangjb@lzu.edu.cn.
authors: Jinbo
authors: J
authors: Yang
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000378:metabolism* / Q000473:pathology; D045744:Cell Line, Tumor; D019008:Drug Resistance, Neoplasm / Q000187:drug effects; D004357:Drug Synergism; D047628:Estrogen Receptor alpha / Q000378:metabolism*; D006801:Humans; D061986:MCF-7 Cells; D051379:Mice; D008807:Mice, Inbred BALB C; D011960:Receptors, Estrogen / Q000378:metabolism*; D012097:Repressor Proteins / Q000378:metabolism*; D020845:Selective Estrogen Receptor Modulators / Q000008:administration & dosage; D013629:Tamoxifen / Q000494:pharmacology*; D016896:Treatment Outcome; D015854:Up-Regulation / Q000187:drug effects
chemical_list: D047628:Estrogen Receptor alpha; D011960:Receptors, Estrogen; D012097:Repressor Proteins; D020845:Selective Estrogen Receptor Modulators; C549924:ZGPAT protein, human; D013629:Tamoxifen
keywords: ER-negative; In vivo; Tamoxifen; ZIP