title: Immunohistochemistry of Telocytes in the Uterus and Fallopian Tubes.
abstract: The seminal work of Popescu and colleagues first demonstrated the existence of a new cell type - the telocytes. We were among the first who reported the presence of such cells in the female genital tract and performed TEM examinations, as well as immunohistochemical staining in the attempt to find a specific marker. Telocytes from rat and from the human uterus and from human fallopian tube were extensively investigated initially by comparison with interstitial cells of Cajal. Progress in telocyte research led to the identification of different subtypes suggestive for a heterogeneous telocyte population which can even coexist in the same location. As a consequence, the functions of TCs are still elusive and can be considered a versatile phenomenon that depends on a variety of conditions, including signal reception and transmission of information via extracellular vesicles or by direct intercellular contact.
authors: Victor Babeş National Institute of Pathology, Bucharest, 050096, Romania. sanda@cretoiu.ro.|Division of Cell Biology and Histology, Carol Davila University of Medicine and Pharmacy, 8 Eroii Sanitari Blvd., Bucharest, 050474, Romania. sanda@cretoiu.ro.
authors: Sanda Maria
authors: SM
authors: Cretoiu
mesh_terms: D000818:Animals; D018952:Antigens, CD34 / Q000235:genetics / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism; D019070:Cell Lineage / Q000502:physiology; D000067128:Extracellular Vesicles / Q000378:metabolism* / Q000648:ultrastructure; D005187:Fallopian Tubes / Q000378:metabolism* / Q000648:ultrastructure; D005260:Female; D015870:Gene Expression; D006801:Humans; D007150:Immunohistochemistry; D046529:Microscopy, Electron, Transmission; D019009:Proto-Oncogene Proteins c-kit / Q000235:genetics / Q000378:metabolism; D051381:Rats; D011980:Receptors, Progesterone / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D000067170:Telocytes / Q000145:classification / Q000378:metabolism* / Q000648:ultrastructure; D014599:Uterus / Q000378:metabolism* / Q000648:ultrastructure
chemical_list: D018952:Antigens, CD34; D015415:Biomarkers; D011980:Receptors, Progesterone; D019009:Proto-Oncogene Proteins c-kit
keywords: Fallopian tube; Immunocytochemical phenotype; Telocytes; Telopodes; Uterus