title: Neurofibromin Expression is Associated with Aggressive Disease and Poor Outcome in Colorectal Carcinoma.
abstract: To assess the predictive and prognostic value of neurofibromin (NF) expression in colorectal carcinoma (CRC).
  
  
  
  The present series consists of archival samples from 191 patients with stage I, II, III, or IV CRC treated between 1981 and 1990 at the Turku University Hospital (Finland). Tumor biopsies as microarray blocks were analyzed for expression of NF by immunohistochemistry. Different grading systems were tested for NF expression.
  
  
  
  A significant correlation between NF expression and tumor localization was found, with tumors arising in the colon showing intense NF expression more often than those arising in the rectum (p=0.014). Higher expression of NF was more common in tumors not responding to treatment (p=0.004). Tumors with multiple metastases showed higher expression of NF than those with single metastasis only (p=0.025). Furthermore, NF expression showed a borderline (p=0.068) correlation with gender; tumors of women showed higher NF expression that those of males. On the other hand, NF expression was not significantly associated with tumor recurrence, age, lymph node involvement, tumor grade and tumor stage or disease outcome.
  
  
  
  Positive NF expression in CRC is a sign of aggressive disease and poor outcome.
authors: Department of Pathology, Faculty of Medicine, Benghazi University, Benghazi, Libya elzagheid@yahoo.com.|Department of Genetic Engineering, Biotechnology Research Center, Tripoli, Libya.
authors: Adam
authors: A
authors: Elzagheid
authors: Department of Pathology, Faculty of Medicine, Benghazi University, Benghazi, Libya.
authors: Fatma
authors: F
authors: Emaetig
authors: Department of Pathology, Faculty of Medicine, Misurata University, Misurata, Libya.
authors: Wesam
authors: W
authors: Elsaghayer
authors: Department of Pathology, Faculty of Medicine, Tripoli University, Tripoli, Libya.
authors: Fairouz
authors: F
authors: Torjman
authors: Department of Surgery, Turku University Hospital and University of Turku, Turku, Finland.
authors: Matti
authors: M
authors: Latto
authors: Department of Oncology and Radiotherapy, Turku University Hospital and University of Turku, Turku, Finland.|Teaching and Research Institute, Barretos Cancer Hospital, Barretos-SP, Brazil.
authors: Kari
authors: K
authors: Syrjänen
authors: Department of Pathology, Turku University Hospital and University of Turku, Turku, Finland.
authors: Yrjö
authors: Y
authors: Collan
authors: Department of Oncology and Radiotherapy, Turku University Hospital and University of Turku, Turku, Finland.
authors: Seppo
authors: S
authors: Pyrhönen
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor; D015179:Colorectal Neoplasms / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D025542:Neurofibromin 1 / Q000378:metabolism*; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor; D025542:Neurofibromin 1
keywords: Neurofibromin (NF) expression; adjuvant therapy; immunohistochemistry; prognosis; treatment