title: Intravoxel incoherent motion (IVIM)-derived parameters in diffusion-weighted MRI: Associations with prognostic factors in invasive ductal carcinoma.
abstract: To investigate relationships between intravoxel incoherent motion (IVIM) metrics of invasive ductal carcinoma of the breast and prognostic factors.
  
  
  
  This retrospective study included a total of 82 masses from 72 patients who underwent 3T breast magnetic resonance imaging (MRI) and diffusion-weighted imaging. IVIM metrics of tissue diffusivity (Dslow), pseudodiffusivity (Dfast), and perfusion fraction (Dpf) were measured using histogram analysis for whole lesion volumes. We evaluated relationships between IVIM metrics and prognostic factors or subtypes of invasive ductal carcinoma.
  
  
  
  The Dslow50th, 75th, and 90thpercentile metrics were reduced in the estrogen receptor (ER)-positive group compared with the ER-negative group (individually, P = 0.044, 0.024, 0.045). Additionally, the Dslow75thpercentile value was a significant differentiator of histologic grade, tumor subtype, and Ki-67 grouping (individually, P = 0.024, 0.049, 0.016). The Dpfmean, 75th, 90thpercentile, skewness, and kurtosis metrics were correlated with the size of ductal carcinoma in situ (DCIS) component (individually, P = 0.034, 0.032, 0.027, 0.013, 0.013).
  
  
  
  The Dslowmetrics differentiated between ER-positive and -negative groups, and the Dpfmetrics were associated with the size of the DCIS component.
  
  
  
  4 J. MAGN. RESON. IMAGING 2017;45:1394-1406.
authors: Department of Radiology, Daejeon St. Mary's Hospital, Seoul, Republic of Korea.
authors: Youn Joo
authors: YJ
authors: Lee
authors: Seoul St. Mary's Hospital, Seoul, Republic of Korea.
authors: Sung Hun
authors: SH
authors: Kim
authors: Seoul St. Mary's Hospital, Seoul, Republic of Korea.
authors: Bong Joo
authors: BJ
authors: Kang
authors: College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors: Young Jee
authors: YJ
authors: Kang
authors: College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors: Heesoo
authors: H
authors: Yoo
authors: College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors: Jaewan
authors: J
authors: Yoo
authors: College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors: Jaeun
authors: J
authors: Lee
authors: Siemens Healthcare, Seoul, Korea.
authors: Yo Han
authors: YH
authors: Son
authors: Siemens Healthcare, Erlangen, Germany.
authors: Robert
authors: R
authors: Grimm
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D001940:Breast / Q000000981:diagnostic imaging; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000000981:diagnostic imaging* / Q000473:pathology; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008875:Middle Aged; D009038:Motion; D010477:Perfusion; D011379:Prognosis; D012189:Retrospective Studies
keywords: diffusion weighted image; intravoxel incoherent motion; invasive ductal carcinoma; magnetic resonance imaging; prognostic factor