title: The Role of Biologically Active Ingredients from Chinese Herbal Medicines in the Regulation of Autophagy in Treating Cardiovascular Diseases and Other Chronic Diseases.
abstract: Autophagy, a highly conserved starvation response mechanism with both defensive and protective effects in eukaryotic cells, is a lysosome-mediated degradation process for non-essential or damaged cellular constituents. It plays an important role in the cell survival, differentiation and development to maintain homeostasis. Autophagy is involved in cardiovascular diseases, cerebrovascular diseases, and neurodegenerative diseases, as well as tumours. Thus, modulating autophagy may provide potential therapeutic strategies. Recently, many active components of Chinese herbal medicines (CHM) have been found to modulate autophagy in myocardial cells, cerebral vascular cells, endothelial cells and tumour cells. This paper reviews the advances in studies on the active components of CHM that modulating autophagy in treating cardiovascular diseases and other chronic diseases over the past five years.
authors: Department of Cardiology, Guang`anmen Hospital, Chinese Academy of Chinese Medical Sciences, Beijing, China.
authors: Jie
authors: J
authors: Li
authors: The Key Laboratory of Chinese Internal Medicine of the Ministry of Education, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, China.
authors: Yonghong
authors: Y
authors: Gao
authors: The Key Laboratory of Chinese Internal Medicine of the Ministry of Education, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, China.
authors: Xiaomeng
authors: X
authors: Ren
authors: Department of Cardiology, Guang`anmen Hospital, Chinese Academy of Chinese Medical Sciences, Beijing, China.
authors: Yanda
authors: Y
authors: Li
authors: The Key Laboratory of Chinese Internal Medicine of the Ministry of Education, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, China.
authors: Lijun
authors: L
authors: Wu
authors: The Key Laboratory of Chinese Internal Medicine of the Ministry of Education, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, China.
authors: Xinyu
authors: X
authors: Yang
authors: Department of Cardiology, Guang`anmen Hospital, Chinese Academy of Chinese Medical Sciences, Beijing, China.
authors: Jie
authors: J
authors: Wang
authors: The Key Laboratory of Chinese Internal Medicine of the Ministry of Education, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, China.
authors: Hongcai
authors: H
authors: Shang
authors: Department of Cardiology, Guang`anmen Hospital, Chinese Academy of Chinese Medical Sciences, Beijing, China.
authors: Xingjiang
authors: X
authors: Xiong
authors: Department of cardiology, Guang`anmen Hospital, Chinese Academy of Chinese Medical Sciences, Beijing, China.
authors: Yanwei
authors: Y
authors: Xing
mesh_terms: D001343:Autophagy / Q000187:drug effects*; D002318:Cardiovascular Diseases / Q000188:drug therapy* / Q000473:pathology; D002561:Cerebrovascular Disorders / Q000188:drug therapy* / Q000473:pathology; D002908:Chronic Disease / Q000188:drug therapy; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology; D019636:Neurodegenerative Diseases / Q000188:drug therapy* / Q000473:pathology
chemical_list: D004365:Drugs, Chinese Herbal
keywords: Autophagy; Chinese herbal medicines; biologically active ingredients; cardiovascular diseases; cerebrovascular diseases; neurodegenerative disease; tumours