title: Aortic Valve Calcification and the Risk of dementia: A Population-Based Study.
abstract: The association of aortic valve calcification (AVC) with dementia remains unknown. In 2,428 non-demented participants from the population-based Rotterdam Study, we investigated the association of CT-assessed AVC with risk of dementia and cognitive decline. AVC was present in 33.1% of the population. During a median follow-up of 9.3 years, 160 participants developed dementia. We found no association between presence of AVC and risk of all-cause dementia [hazard ratio (HR): 0.89 (95% confidence interval (CI):0.63;1.26)]. Presence of AVC was not associated with cognitive decline on any of the cognitive tests, nor with a measure of global cognition.
authors: Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.|Department of Neurology, Erasmus MC, Rotterdam, the Netherlands.
authors: Frank J
authors: FJ
authors: Wolters
authors: Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.|Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, the Netherlands.|Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, USA.
authors: Daniel
authors: D
authors: Bos
authors: Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.|Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, the Netherlands.
authors: Meike W
authors: MW
authors: Vernooij
authors: Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.
authors: Oscar H
authors: OH
authors: Franco
authors: Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.|Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, USA.
authors: Albert
authors: A
authors: Hofman
authors: Department of Neurology, Erasmus MC, Rotterdam, the Netherlands.
authors: Peter J
authors: PJ
authors: Koudstaal
authors: Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, the Netherlands.
authors: Aad
authors: A
authors: van der Lugt
authors: Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.|Department of Neurology, Erasmus MC, Rotterdam, the Netherlands.|Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, the Netherlands.
authors: M Arfan
authors: MA
authors: Ikram
mesh_terms: D000368:Aged; D001021:Aortic Valve / Q000000981:diagnostic imaging / Q000473:pathology*; D001024:Aortic Valve Stenosis / Q000000981:diagnostic imaging / Q000453:epidemiology*; D002114:Calcinosis / Q000000981:diagnostic imaging / Q000453:epidemiology*; D015331:Cohort Studies; D018672:Community Health Planning; D003704:Dementia / Q000000981:diagnostic imaging / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D014057:Tomography, X-Ray Computed
keywords: Aortic valve pathology; calcification; dementia; epidemiology; imaging