title: Diagnostic value of fibulin-3 for malignant pleural mesothelioma: A systematic review and meta-analysis.
abstract: BACKGROUND
  Several studies have investigated the diagnostic value of fibulin-3 for malignant pleural mesothelioma (MPM), but the results were various. Therefore, we performed a systematic review and meta-analysis to evaluate the diagnostic value of fibulin-3 for MPM.
  
  
  RESULTS
  Eight studies were included in this work. The overall sensitivity of blood fibulin-3 were 0.87 (95% CI, 0.58 - 0.97) and 0.89 (95% CI, 0.77 - 0.95), respectively. The overall sensitivity and specificity of PF fibulin-3 for MPM were 0.73 (95% CI, 0.54 - 0.86) and 0.80 (95% CI, 0.60 - 0.91), respectively. The area under curve of blood and pleural effusion (PF) Fibulin-3 were 0.94 (95% CI, 0.91 - 0.96) 0.83 (95% CI, 0.79 - 0.86), respectively.
  
  
  METHODS
  PubMed and EMBASE databases were searched up to July 29, 2016 to verify studies investigating the diagnostic value of fibulin-3 for MPM. The quality of eligible studies was assessed using the revised Quality Assessment for Studies of Diagnostic Accuracy tool (QUADAS-2). The overall sensitivity and specificity were pooled using a bivariate model.
  
  
  CONCLUSIONS
  Fibuoin-3 is a useful diagnostic marker for MPM.
authors: Division of Scientific Research, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, China.
authors: Ran
authors: R
authors: Ren
authors: Division of Scientific Research, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, China.
authors: Pengpeng
authors: P
authors: Yin
authors: Division of Scientific Research, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, China.
authors: Yan
authors: Y
authors: Zhang
authors: Division of Scientific Research, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, China.
authors: Jianyun
authors: J
authors: Zhou
authors: Division of Scientific Research, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, China.
authors: Yixing
authors: Y
authors: Zhou
authors: Division of Scientific Research, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, China.
authors: Rufu
authors: R
authors: Xu
authors: Department of Scientific Research, Third Military Medical University, Chongqing, 400038, China.
authors: Hai
authors: H
authors: Lin
authors: Department of Scientific Research, Third Military Medical University, Chongqing, 400038, China.
authors: Chunji
authors: C
authors: Huang
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood*; D016326:Extracellular Matrix Proteins / Q000097:blood*; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis*; D008654:Mesothelioma / Q000175:diagnosis*; D000086002:Mesothelioma, Malignant; D010997:Pleural Neoplasms / Q000175:diagnosis*; D011237:Predictive Value of Tests; D011379:Prognosis; D012680:Sensitivity and Specificity
chemical_list: D014408:Biomarkers, Tumor; C119630:EFEMP1 protein, human; D016326:Extracellular Matrix Proteins
keywords: Fibulin-3; diagnostic value; malignant pleural mesothelioma; meta-analysis; systematic review