title: Urine metabolic profiling for the pathogenesis research of erosive oral lichen planus.
abstract: OBJECTIVE
  Oral lichen planus (OLP) is a relatively common chronic immune-pathological and inflammatory disease and potentially oral precancerous lesion. Erosive OLP patients show the higher rate of malignant transformation than patients with non-erosive OLP. Identifying the potential biomarkers related to erosive OLP may help to understand the pathogenesis of the diseases.
  
  
  METHODS
  Metabolic profiles were compared in control and patient subjects with erosive OLP by using ultra-performance liquid chromatography-quadrupole time-of-flight-mass spectrometry (UPLC-QTOF-MS) coupled with pattern recognition methods An integrative analysis was used to identify the perturbed metabolic pathways and pathological processes that may be associated with the disease.
  
  
  RESULTS
  In total, 12 modulated metabolites were identified and considered as the potential biomarkers of erosive OLP. Multiple metabolic pathways and pathological processes were involved in erosive OLP.
  
  
  CONCLUSIONS
  The dysregulations of these metabolites could be used to explain the pathogenesis of the disease, which could also be the potential therapeutic targets for the disease.
authors: Department of Pharmacy, GuiYang College of Traditional Chinese Medicine, Guiyang 550025, PR China.
authors: Xu-Zhao
authors: XZ
authors: Li
authors: First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin 150040, PR China. Electronic address: 444125750@qq.com.
authors: Xu-Yan
authors: XY
authors: Yang
authors: Chinese Medicine Toxicological Laboratory, Heilongjiang University of Chinese Medicine, Harbin 150040, PR China.
authors: Yu
authors: Y
authors: Wang
authors: Department of Pharmacy, GuiYang College of Traditional Chinese Medicine, Guiyang 550025, PR China. Electronic address: laurahoney@163.com.
authors: Shuai-Nan
authors: SN
authors: Zhang
authors: First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin 150040, PR China.
authors: Wei
authors: W
authors: Zou
authors: First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin 150040, PR China.
authors: Yan
authors: Y
authors: Wang
authors: First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin 150040, PR China.
authors: Xiao-Nan
authors: XN
authors: Li
authors: First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin 150040, PR China.
authors: Ling-Shu
authors: LS
authors: Wang
authors: First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin 150040, PR China.
authors: Zhi-Gang
authors: ZG
authors: Zhang
authors: First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin 150040, PR China.
authors: Liang-Zhen
authors: LZ
authors: Xie
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000652:urine*; D050260:Carbohydrate Metabolism; D002853:Chromatography, Liquid; D005260:Female; D006801:Humans; D017676:Lichen Planus, Oral / Q000378:metabolism / Q000473:pathology / Q000652:urine*; D008297:Male; D013058:Mass Spectrometry; D053858:Metabolic Networks and Pathways; D055432:Metabolomics / Q000379:methods; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology; D000069292:Pyroptosis / Q000502:physiology
chemical_list: D015415:Biomarkers
keywords: Erosive oral lichen planus; Metabonomics; Potential biomarkers