title: Genetic variants of MCP-1 and CCR2 genes and IgA nephropathy risk.
abstract: Monocyte chemoattractant protein-1 (MCP-1) and its receptor CCR2 stimulate inflammation response by activating and recruiting monocytes/macrophages. MCP-1 and CCR2 polymorphisms were reported to be associated with various diseases. To explore the relationship between MCP-1 and CCR2 polymorphisms and IgA nephropathy (IgAN), we conducted this case-control study by enrolling 351 IgAN patients and 310 health controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to evaluate potential associations of MCP-1 and CCR2 polymorphisms with susceptibility and clinical parameters of IgAN. No statistical differences between IgAN group and the control group in the MCP-1 -2518 and CCR2 +190 genotypic groups were observed (P > 0.05). Individuals with MCP-1 -2518 GG genotypes had a higher blood pressure (GG vs. AA+AG: OR = 1.79, 95% CI = 1.07-2.99, P = 0.026) and Lee's grade (GG vs. AA+AG: OR = 2.05, 95% CI = 1.19-3.54, P = 0.009; GG vs. AA: OR = 2.24, 95% CI = 1.19-4.20, P = 0.01), compared with patients with AA/AG genotypes. A significant association between CCR2 +190 polymorphism and Lee's grades was observed (GA+AA vs. GG: OR = 2.66, 95% CI = 1.63-4.35, P < 0.001; GA vs. AA+GG: OR = 2.27, 95% CI = 1.39-3.70, P = 0.001). Our results indicated that MCP-1 and CCR2 polymorphisms may influence the progression of IgAN, but not increase/decrease its susceptibility.
authors: Department of Nephrology, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China.
authors: Jie
authors: J
authors: Gao
authors: Department of Oncology, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China.
authors: Xinghan
authors: X
authors: Liu
authors: Department of Nephrology, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China.
authors: Linting
authors: L
authors: Wei
authors: Department of Nephrology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.
authors: Dan
authors: D
authors: Niu
authors: Department of Nephrology, Hainan general hospital, Haikou 570311, China.
authors: Jiali
authors: J
authors: Wei
authors: Department of Nephrology, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China.
authors: Li
authors: L
authors: Wang
authors: Department of Nephrology, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China.
authors: Heng
authors: H
authors: Ge
authors: Department of Oncology, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China.
authors: Meng
authors: M
authors: Wang
authors: Department of Pathology, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China.
authors: Qiaoling
authors: Q
authors: Yu
authors: National Engineering Research Center for Miniaturized Detection Systems, School of Life Sciences, Northwest University, Xi'an 710069, China.
authors: Tianbo
authors: T
authors: Jin
authors: Department of Oncology, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China.
authors: Tian
authors: T
authors: Tian
authors: Department of Oncology, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China.
authors: Zhijun
authors: Z
authors: Dai
authors: Department of Nephrology, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China.
authors: Rongguo
authors: R
authors: Fu
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D018932:Chemokine CCL2 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005922:Glomerulonephritis, IGA / Q000235:genetics* / Q000473:pathology; D006801:Humans; D008297:Male; D054390:Receptors, CCR2 / Q000235:genetics*; D012307:Risk Factors
chemical_list: C111835:CCL2 protein, human; C515334:CCR2 protein, human; D018932:Chemokine CCL2; D054390:Receptors, CCR2
keywords: IgA nephropathy; case-control study; monocyte chemoattractant protein-1; polymorphism; risk