title: Relationship among physical activity, sedentary behaviors, and cardiometabolic risk factors during gastric bypass surgery-induced weight loss.
abstract: BACKGROUND
  The impact of daily physical activity (PA) on the cardiometabolic risk of bariatric surgery patients is not known.
  
  
  OBJECTIVE
  We examined the influence of physical activity and sedentary behavior on modifying cardiometabolic risk after Roux-en-Y gastric bypass (RYGB) surgery.
  
  
  METHODS
  University of Pittsburgh Medical Center and East Carolina University bariatric surgery centers.
  
  
  METHODS
  Data from 43 women and 7 men who completed testing at 1-3 months after RYGB surgery and again at 9 months postsurgery were analyzed. Outcomes measured included PA level (min/d), steps/d, sedentary time, and body composition. Insulin sensitivity was determined with an intravenous glucose tolerance test. Weight and blood lipid profiles also were obtained.
  
  
  RESULTS
  Patients reduced body mass index by a mean of -8.0±3.4 kg/m2(P<.001), increased moderate-to-vigorous PA by 17.0±47.0 min/d (P = .014), and decreased sedentary time (-47.9±101.0 min/d, P = .002). However, 24% of patients decreased overall PA (P<.001), and 39% increased sedentary behavior (P<.001). Changes in overall PA (rho = -.33, P = .006) and steps/d (rho = -.31, P = .0106) were related to weight loss. Insulin sensitivity was associated with light PA before (rho = .37, P<.001) and after (rho = .37, P = .015) intervention. Increasing overall PA also was related to higher levels of high-density lipoprotein cholesterol (rho = .33, P<.01). Decreasing sedentary time was related to decreased fat mass (rho = .35, P = .012) but not to other cardiometabolic risk factors.
  
  
  CONCLUSIONS
  The majority of patients increased PA (76%) and decreased sedentary time (61%) after RYGB surgery, but the amount of PA and sedentary time varied substantially. Higher PA, even at low intensity levels, was related to beneficial outcomes in body composition, insulin sensitivity, and high-density lipoprotein cholesterol.
authors: Translational Research Institute for Metabolism and Diabetes, Florida Hospital, Orlando, FL.
authors: Jakob F
authors: JF
authors: Wefers
authors: Translational Research Institute for Metabolism and Diabetes, Florida Hospital, Orlando, FL.
authors: Tracey L
authors: TL
authors: Woodlief
authors: Translational Research Institute for Metabolism and Diabetes, Florida Hospital, Orlando, FL.
authors: Elvis A
authors: EA
authors: Carnero
authors: Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, PA.
authors: Nicole L
authors: NL
authors: Helbling
authors: Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, PA.
authors: Steven J
authors: SJ
authors: Anthony
authors: Department of Kinesiology, East Carolina University, Greenville, NC.
authors: Gabriel S
authors: GS
authors: Dubis
authors: Department of Health and Physical Activity, University of Pittsburgh, Pittsburgh, PA.
authors: John M
authors: JM
authors: Jakicic
authors: Department of Kinesiology, East Carolina University, Greenville, NC.
authors: Joseph A
authors: JA
authors: Houmard
authors: Translational Research Institute for Metabolism and Diabetes, Florida Hospital, Orlando, FL; Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, PA.
authors: Bret H
authors: BH
authors: Goodpaster
authors: Translational Research Institute for Metabolism and Diabetes, Florida Hospital, Orlando, FL; Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, PA; Department of Health and Physical Activity, University of Pittsburgh, Pittsburgh, PA. Electronic address: paul.coen@flhosp.org.
authors: Paul M
authors: PM
authors: Coen
mesh_terms: D000328:Adult; D002318:Cardiovascular Diseases / Q000209:etiology*; D008078:Cholesterol, LDL / Q000378:metabolism; D015444:Exercise / Q000502:physiology*; D005260:Female; D015390:Gastric Bypass; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D050356:Lipid Metabolism / Q000502:physiology; D008297:Male; D008659:Metabolic Diseases / Q000209:etiology*; D008875:Middle Aged; D018670:Monitoring, Ambulatory; D009767:Obesity, Morbid / Q000601:surgery; D011182:Postoperative Care; D012307:Risk Factors; D057185:Sedentary Behavior; D013531:Surgicenters; D015431:Weight Loss / Q000502:physiology*; D055815:Young Adult
chemical_list: D008078:Cholesterol, LDL
keywords: Accelerometer; Physical activity; Roux-en-Y gastric bypass surgery