title: In vivo visualization of tau deposits in corticobasal syndrome by 18F-THK5351 PET.
abstract: OBJECTIVE
  To determine whether18F-THK5351 PET can be used to visualize tau deposits in brain lesions in live patients with corticobasal syndrome (CBS).
  
  
  METHODS
  We evaluated the in vitro binding of3H-THK5351 in postmortem brain tissues from a patient with corticobasal degeneration (CBD). In clinical PET studies,18F-THK5351 retention in 5 patients with CBS was compared to that in 8 age-matched normal controls and 8 patients with Alzheimer disease (AD).
  
  
  RESULTS
  3H-THK5351 was able to bind to tau deposits in the postmortem brain with CBD. In clinical PET studies, the 5 patients with CBS showed significantly higher18F-THK5351 retention in the frontal, parietal, and globus pallidus than the 8 age-matched normal controls and patients with AD. Higher18F-THK5351 retention was observed contralaterally to the side associated with greater cortical dysfunction and parkinsonism.
  
  
  CONCLUSIONS
  18F-THK5351 PET demonstrated high tracer signal in sites susceptible to tau deposition in patients with CBS.18F-THK5351 should be considered as a promising candidate radiotracer for the in vivo imaging of tau deposits in CBS.
authors: From the Departments of Neurology (A.K., T.H., T.B., N.S., R.O., S.Y., J.K., M.E., M.A.), Pharmacology (N.O., R.H., K.Y.), and Diagnostic Radiology (S.M.), Tohoku University Graduate School of Medicine; Divisions of Cyclotron Nuclear Medicine (S.W., K.H., M.T.) and Radiopharmaceutical Chemistry (Y.F., R.I., S.F.), Cyclotron and Radioisotope Center, and Department of Geriatric and Respiratory Medicine (A.I., K.F., H.A.) and Division of Neuroimaging (Y.K.), Institute of Development, Aging and Cancer, Tohoku University; Department of Neurology (M.K.), Tohoku Pharmaceutical University Hospital; Department of Neurology (O.T.), Sendai Medical Center; and Department of Neurology (A.T.), National Hospital Organization, Sendai Nishitaga Hospital, Sendai, Japan. akikuchi@med.tohoku.ac.jp nookamura@med.tohoku.ac.jp.
authors: Akio
authors: A
authors: Kikuchi
authors: From the Departments of Neurology (A.K., T.H., T.B., N.S., R.O., S.Y., J.K., M.E., M.A.), Pharmacology (N.O., R.H., K.Y.), and Diagnostic Radiology (S.M.), Tohoku University Graduate School of Medicine; Divisions of Cyclotron Nuclear Medicine (S.W., K.H., M.T.) and Radiopharmaceutical Chemistry (Y.F., R.I., S.F.), Cyclotron and Radioisotope Center, and Department of Geriatric and Respiratory Medicine (A.I., K.F., H.A.) and Division of Neuroimaging (Y.K.), Institute of Development, Aging and Cancer, Tohoku University; Department of Neurology (M.K.), Tohoku Pharmaceutical University Hospital; Department of Neurology (O.T.), Sendai Medical Center; and Department of Neurology (A.T.), National Hospital Organization, Sendai Nishitaga Hospital, Sendai, Japan. akikuchi@med.tohoku.ac.jp nookamura@med.tohoku.ac.jp.
authors: Nobuyuki
authors: N
authors: Okamura
authors: From the Departments of Neurology (A.K., T.H., T.B., N.S., R.O., S.Y., J.K., M.E., M.A.), Pharmacology (N.O., R.H., K.Y.), and Diagnostic Radiology (S.M.), Tohoku University Graduate School of Medicine; Divisions of Cyclotron Nuclear Medicine (S.W., K.H., M.T.) and Radiopharmaceutical Chemistry (Y.F., R.I., S.F.), Cyclotron and Radioisotope Center, and Department of Geriatric and Respiratory Medicine (A.I., K.F., H.A.) and Division of Neuroimaging (Y.K.), Institute of Development, Aging and Cancer, Tohoku University; Department of Neurology (M.K.), Tohoku Pharmaceutical University Hospital; Department of Neurology (O.T.), Sendai Medical Center; and Department of Neurology (A.T.), National Hospital Organization, Sendai Nishitaga Hospital, Sendai, Japan.
authors: Takafumi
authors: T
authors: Hasegawa
authors: From the Departments of Neurology (A.K., T.H., T.B., N.S., R.O., S.Y., J.K., M.E., M.A.), Pharmacology (N.O., R.H., K.Y.), and Diagnostic Radiology (S.M.), Tohoku University Graduate School of Medicine; Divisions of Cyclotron Nuclear Medicine (S.W., K.H., M.T.) and Radiopharmaceutical Chemistry (Y.F., R.I., S.F.), Cyclotron and Radioisotope Center, and Department of Geriatric and Respiratory Medicine (A.I., K.F., H.A.) and Division of Neuroimaging (Y.K.), Institute of Development, Aging and Cancer, Tohoku University; Department of Neurology (M.K.), Tohoku Pharmaceutical University Hospital; Department of Neurology (O.T.), Sendai Medical Center; and Department of Neurology (A.T.), National Hospital Organization, Sendai Nishitaga Hospital, Sendai, Japan.
authors: Ryuichi
authors: R
authors: Harada
authors: From the Departments of Neurology (A.K., T.H., T.B., N.S., R.O., S.Y., J.K., M.E., M.A.), Pharmacology (N.O., R.H., K.Y.), and Diagnostic Radiology (S.M.), Tohoku University Graduate School of Medicine; Divisions of Cyclotron Nuclear Medicine (S.W., K.H., M.T.) and Radiopharmaceutical Chemistry (Y.F., R.I., S.F.), Cyclotron and Radioisotope Center, and Department of Geriatric and Respiratory Medicine (A.I., K.F., H.A.) and Division of Neuroimaging (Y.K.), Institute of Development, Aging and Cancer, Tohoku University; Department of Neurology (M.K.), Tohoku Pharmaceutical University Hospital; Department of Neurology (O.T.), Sendai Medical Center; and Department of Neurology (A.T.), National Hospital Organization, Sendai Nishitaga Hospital, Sendai, Japan.
authors: Shoichi
authors: S
authors: Watanuki
authors: From the Departments of Neurology (A.K., T.H., T.B., N.S., R.O., S.Y., J.K., M.E., M.A.), Pharmacology (N.O., R.H., K.Y.), and Diagnostic Radiology (S.M.), Tohoku University Graduate School of Medicine; Divisions of Cyclotron Nuclear Medicine (S.W., K.H., M.T.) and Radiopharmaceutical Chemistry (Y.F., R.I., S.F.), Cyclotron and Radioisotope Center, and Department of Geriatric and Respiratory Medicine (A.I., K.F., H.A.) and Division of Neuroimaging (Y.K.), Institute of Development, Aging and Cancer, Tohoku University; Department of Neurology (M.K.), Tohoku Pharmaceutical University Hospital; Department of Neurology (O.T.), Sendai Medical Center; and Department of Neurology (A.T.), National Hospital Organization, Sendai Nishitaga Hospital, Sendai, Japan.
authors: Yoshihito
authors: Y
authors: Funaki
authors: From the Departments of Neurology (A.K., T.H., T.B., N.S., R.O., S.Y., J.K., M.E., M.A.), Pharmacology (N.O., R.H., K.Y.), and Diagnostic Radiology (S.M.), Tohoku University Graduate School of Medicine; Divisions of Cyclotron Nuclear Medicine (S.W., K.H., M.T.) and Radiopharmaceutical Chemistry (Y.F., R.I., S.F.), Cyclotron and Radioisotope Center, and Department of Geriatric and Respiratory Medicine (A.I., K.F., H.A.) and Division of Neuroimaging (Y.K.), Institute of Development, Aging and Cancer, Tohoku University; Department of Neurology (M.K.), Tohoku Pharmaceutical University Hospital; Department of Neurology (O.T.), Sendai Medical Center; and Department of Neurology (A.T.), National Hospital Organization, Sendai Nishitaga Hospital, Sendai, Japan.
authors: Kotaro
authors: K
authors: Hiraoka
authors: From the Departments of Neurology (A.K., T.H., T.B., N.S., R.O., S.Y., J.K., M.E., M.A.), Pharmacology (N.O., R.H., K.Y.), and Diagnostic Radiology (S.M.), Tohoku University Graduate School of Medicine; Divisions of Cyclotron Nuclear Medicine (S.W., K.H., M.T.) and Radiopharmaceutical Chemistry (Y.F., R.I., S.F.), Cyclotron and Radioisotope Center, and Department of Geriatric and Respiratory Medicine (A.I., K.F., H.A.) and Division of Neuroimaging (Y.K.), Institute of Development, Aging and Cancer, Tohoku University; Department of Neurology (M.K.), Tohoku Pharmaceutical University Hospital; Department of Neurology (O.T.), Sendai Medical Center; and Department of Neurology (A.T.), National Hospital Organization, Sendai Nishitaga Hospital, Sendai, Japan.
authors: Toru
authors: T
authors: Baba
authors: From the Departments of Neurology (A.K., T.H., T.B., N.S., R.O., S.Y., J.K., M.E., M.A.), Pharmacology (N.O., R.H., K.Y.), and Diagnostic Radiology (S.M.), Tohoku University Graduate School of Medicine; Divisions of Cyclotron Nuclear Medicine (S.W., K.H., M.T.) and Radiopharmaceutical Chemistry (Y.F., R.I., S.F.), Cyclotron and Radioisotope Center, and Department of Geriatric and Respiratory Medicine (A.I., K.F., H.A.) and Division of Neuroimaging (Y.K.), Institute of Development, Aging and Cancer, Tohoku University; Department of Neurology (M.K.), Tohoku Pharmaceutical University Hospital; Department of Neurology (O.T.), Sendai Medical Center; and Department of Neurology (A.T.), National Hospital Organization, Sendai Nishitaga Hospital, Sendai, Japan.
authors: Naoto
authors: N
authors: Sugeno
authors: From the Departments of Neurology (A.K., T.H., T.B., N.S., R.O., S.Y., J.K., M.E., M.A.), Pharmacology (N.O., R.H., K.Y.), and Diagnostic Radiology (S.M.), Tohoku University Graduate School of Medicine; Divisions of Cyclotron Nuclear Medicine (S.W., K.H., M.T.) and Radiopharmaceutical Chemistry (Y.F., R.I., S.F.), Cyclotron and Radioisotope Center, and Department of Geriatric and Respiratory Medicine (A.I., K.F., H.A.) and Division of Neuroimaging (Y.K.), Institute of Development, Aging and Cancer, Tohoku University; Department of Neurology (M.K.), Tohoku Pharmaceutical University Hospital; Department of Neurology (O.T.), Sendai Medical Center; and Department of Neurology (A.T.), National Hospital Organization, Sendai Nishitaga Hospital, Sendai, Japan.
authors: Ryuji
authors: R
authors: Oshima
authors: From the Departments of Neurology (A.K., T.H., T.B., N.S., R.O., S.Y., J.K., M.E., M.A.), Pharmacology (N.O., R.H., K.Y.), and Diagnostic Radiology (S.M.), Tohoku University Graduate School of Medicine; Divisions of Cyclotron Nuclear Medicine (S.W., K.H., M.T.) and Radiopharmaceutical Chemistry (Y.F., R.I., S.F.), Cyclotron and Radioisotope Center, and Department of Geriatric and Respiratory Medicine (A.I., K.F., H.A.) and Division of Neuroimaging (Y.K.), Institute of Development, Aging and Cancer, Tohoku University; Department of Neurology (M.K.), Tohoku Pharmaceutical University Hospital; Department of Neurology (O.T.), Sendai Medical Center; and Department of Neurology (A.T.), National Hospital Organization, Sendai Nishitaga Hospital, Sendai, Japan.
authors: Shun
authors: S
authors: Yoshida
authors: From the Departments of Neurology (A.K., T.H., T.B., N.S., R.O., S.Y., J.K., M.E., M.A.), Pharmacology (N.O., R.H., K.Y.), and Diagnostic Radiology (S.M.), Tohoku University Graduate School of Medicine; Divisions of Cyclotron Nuclear Medicine (S.W., K.H., M.T.) and Radiopharmaceutical Chemistry (Y.F., R.I., S.F.), Cyclotron and Radioisotope Center, and Department of Geriatric and Respiratory Medicine (A.I., K.F., H.A.) and Division of Neuroimaging (Y.K.), Institute of Development, Aging and Cancer, Tohoku University; Department of Neurology (M.K.), Tohoku Pharmaceutical University Hospital; Department of Neurology (O.T.), Sendai Medical Center; and Department of Neurology (A.T.), National Hospital Organization, Sendai Nishitaga Hospital, Sendai, Japan.
authors: Junpei
authors: J
authors: Kobayashi
authors: From the Departments of Neurology (A.K., T.H., T.B., N.S., R.O., S.Y., J.K., M.E., M.A.), Pharmacology (N.O., R.H., K.Y.), and Diagnostic Radiology (S.M.), Tohoku University Graduate School of Medicine; Divisions of Cyclotron Nuclear Medicine (S.W., K.H., M.T.) and Radiopharmaceutical Chemistry (Y.F., R.I., S.F.), Cyclotron and Radioisotope Center, and Department of Geriatric and Respiratory Medicine (A.I., K.F., H.A.) and Division of Neuroimaging (Y.K.), Institute of Development, Aging and Cancer, Tohoku University; Department of Neurology (M.K.), Tohoku Pharmaceutical University Hospital; Department of Neurology (O.T.), Sendai Medical Center; and Department of Neurology (A.T.), National Hospital Organization, Sendai Nishitaga Hospital, Sendai, Japan.
authors: Michinori
authors: M
authors: Ezura
authors: From the Departments of Neurology (A.K., T.H., T.B., N.S., R.O., S.Y., J.K., M.E., M.A.), Pharmacology (N.O., R.H., K.Y.), and Diagnostic Radiology (S.M.), Tohoku University Graduate School of Medicine; Divisions of Cyclotron Nuclear Medicine (S.W., K.H., M.T.) and Radiopharmaceutical Chemistry (Y.F., R.I., S.F.), Cyclotron and Radioisotope Center, and Department of Geriatric and Respiratory Medicine (A.I., K.F., H.A.) and Division of Neuroimaging (Y.K.), Institute of Development, Aging and Cancer, Tohoku University; Department of Neurology (M.K.), Tohoku Pharmaceutical University Hospital; Department of Neurology (O.T.), Sendai Medical Center; and Department of Neurology (A.T.), National Hospital Organization, Sendai Nishitaga Hospital, Sendai, Japan.
authors: Michiko
authors: M
authors: Kobayashi
authors: From the Departments of Neurology (A.K., T.H., T.B., N.S., R.O., S.Y., J.K., M.E., M.A.), Pharmacology (N.O., R.H., K.Y.), and Diagnostic Radiology (S.M.), Tohoku University Graduate School of Medicine; Divisions of Cyclotron Nuclear Medicine (S.W., K.H., M.T.) and Radiopharmaceutical Chemistry (Y.F., R.I., S.F.), Cyclotron and Radioisotope Center, and Department of Geriatric and Respiratory Medicine (A.I., K.F., H.A.) and Division of Neuroimaging (Y.K.), Institute of Development, Aging and Cancer, Tohoku University; Department of Neurology (M.K.), Tohoku Pharmaceutical University Hospital; Department of Neurology (O.T.), Sendai Medical Center; and Department of Neurology (A.T.), National Hospital Organization, Sendai Nishitaga Hospital, Sendai, Japan.
authors: Ohito
authors: O
authors: Tano
authors: From the Departments of Neurology (A.K., T.H., T.B., N.S., R.O., S.Y., J.K., M.E., M.A.), Pharmacology (N.O., R.H., K.Y.), and Diagnostic Radiology (S.M.), Tohoku University Graduate School of Medicine; Divisions of Cyclotron Nuclear Medicine (S.W., K.H., M.T.) and Radiopharmaceutical Chemistry (Y.F., R.I., S.F.), Cyclotron and Radioisotope Center, and Department of Geriatric and Respiratory Medicine (A.I., K.F., H.A.) and Division of Neuroimaging (Y.K.), Institute of Development, Aging and Cancer, Tohoku University; Department of Neurology (M.K.), Tohoku Pharmaceutical University Hospital; Department of Neurology (O.T.), Sendai Medical Center; and Department of Neurology (A.T.), National Hospital Organization, Sendai Nishitaga Hospital, Sendai, Japan.
authors: Shunji
authors: S
authors: Mugikura
authors: From the Departments of Neurology (A.K., T.H., T.B., N.S., R.O., S.Y., J.K., M.E., M.A.), Pharmacology (N.O., R.H., K.Y.), and Diagnostic Radiology (S.M.), Tohoku University Graduate School of Medicine; Divisions of Cyclotron Nuclear Medicine (S.W., K.H., M.T.) and Radiopharmaceutical Chemistry (Y.F., R.I., S.F.), Cyclotron and Radioisotope Center, and Department of Geriatric and Respiratory Medicine (A.I., K.F., H.A.) and Division of Neuroimaging (Y.K.), Institute of Development, Aging and Cancer, Tohoku University; Department of Neurology (M.K.), Tohoku Pharmaceutical University Hospital; Department of Neurology (O.T.), Sendai Medical Center; and Department of Neurology (A.T.), National Hospital Organization, Sendai Nishitaga Hospital, Sendai, Japan.
authors: Ren
authors: R
authors: Iwata
authors: From the Departments of Neurology (A.K., T.H., T.B., N.S., R.O., S.Y., J.K., M.E., M.A.), Pharmacology (N.O., R.H., K.Y.), and Diagnostic Radiology (S.M.), Tohoku University Graduate School of Medicine; Divisions of Cyclotron Nuclear Medicine (S.W., K.H., M.T.) and Radiopharmaceutical Chemistry (Y.F., R.I., S.F.), Cyclotron and Radioisotope Center, and Department of Geriatric and Respiratory Medicine (A.I., K.F., H.A.) and Division of Neuroimaging (Y.K.), Institute of Development, Aging and Cancer, Tohoku University; Department of Neurology (M.K.), Tohoku Pharmaceutical University Hospital; Department of Neurology (O.T.), Sendai Medical Center; and Department of Neurology (A.T.), National Hospital Organization, Sendai Nishitaga Hospital, Sendai, Japan.
authors: Aiko
authors: A
authors: Ishiki
authors: From the Departments of Neurology (A.K., T.H., T.B., N.S., R.O., S.Y., J.K., M.E., M.A.), Pharmacology (N.O., R.H., K.Y.), and Diagnostic Radiology (S.M.), Tohoku University Graduate School of Medicine; Divisions of Cyclotron Nuclear Medicine (S.W., K.H., M.T.) and Radiopharmaceutical Chemistry (Y.F., R.I., S.F.), Cyclotron and Radioisotope Center, and Department of Geriatric and Respiratory Medicine (A.I., K.F., H.A.) and Division of Neuroimaging (Y.K.), Institute of Development, Aging and Cancer, Tohoku University; Department of Neurology (M.K.), Tohoku Pharmaceutical University Hospital; Department of Neurology (O.T.), Sendai Medical Center; and Department of Neurology (A.T.), National Hospital Organization, Sendai Nishitaga Hospital, Sendai, Japan.
authors: Katsutoshi
authors: K
authors: Furukawa
authors: From the Departments of Neurology (A.K., T.H., T.B., N.S., R.O., S.Y., J.K., M.E., M.A.), Pharmacology (N.O., R.H., K.Y.), and Diagnostic Radiology (S.M.), Tohoku University Graduate School of Medicine; Divisions of Cyclotron Nuclear Medicine (S.W., K.H., M.T.) and Radiopharmaceutical Chemistry (Y.F., R.I., S.F.), Cyclotron and Radioisotope Center, and Department of Geriatric and Respiratory Medicine (A.I., K.F., H.A.) and Division of Neuroimaging (Y.K.), Institute of Development, Aging and Cancer, Tohoku University; Department of Neurology (M.K.), Tohoku Pharmaceutical University Hospital; Department of Neurology (O.T.), Sendai Medical Center; and Department of Neurology (A.T.), National Hospital Organization, Sendai Nishitaga Hospital, Sendai, Japan.
authors: Hiroyuki
authors: H
authors: Arai
authors: From the Departments of Neurology (A.K., T.H., T.B., N.S., R.O., S.Y., J.K., M.E., M.A.), Pharmacology (N.O., R.H., K.Y.), and Diagnostic Radiology (S.M.), Tohoku University Graduate School of Medicine; Divisions of Cyclotron Nuclear Medicine (S.W., K.H., M.T.) and Radiopharmaceutical Chemistry (Y.F., R.I., S.F.), Cyclotron and Radioisotope Center, and Department of Geriatric and Respiratory Medicine (A.I., K.F., H.A.) and Division of Neuroimaging (Y.K.), Institute of Development, Aging and Cancer, Tohoku University; Department of Neurology (M.K.), Tohoku Pharmaceutical University Hospital; Department of Neurology (O.T.), Sendai Medical Center; and Department of Neurology (A.T.), National Hospital Organization, Sendai Nishitaga Hospital, Sendai, Japan.
authors: Shozo
authors: S
authors: Furumoto
authors: From the Departments of Neurology (A.K., T.H., T.B., N.S., R.O., S.Y., J.K., M.E., M.A.), Pharmacology (N.O., R.H., K.Y.), and Diagnostic Radiology (S.M.), Tohoku University Graduate School of Medicine; Divisions of Cyclotron Nuclear Medicine (S.W., K.H., M.T.) and Radiopharmaceutical Chemistry (Y.F., R.I., S.F.), Cyclotron and Radioisotope Center, and Department of Geriatric and Respiratory Medicine (A.I., K.F., H.A.) and Division of Neuroimaging (Y.K.), Institute of Development, Aging and Cancer, Tohoku University; Department of Neurology (M.K.), Tohoku Pharmaceutical University Hospital; Department of Neurology (O.T.), Sendai Medical Center; and Department of Neurology (A.T.), National Hospital Organization, Sendai Nishitaga Hospital, Sendai, Japan.
authors: Manabu
authors: M
authors: Tashiro
authors: From the Departments of Neurology (A.K., T.H., T.B., N.S., R.O., S.Y., J.K., M.E., M.A.), Pharmacology (N.O., R.H., K.Y.), and Diagnostic Radiology (S.M.), Tohoku University Graduate School of Medicine; Divisions of Cyclotron Nuclear Medicine (S.W., K.H., M.T.) and Radiopharmaceutical Chemistry (Y.F., R.I., S.F.), Cyclotron and Radioisotope Center, and Department of Geriatric and Respiratory Medicine (A.I., K.F., H.A.) and Division of Neuroimaging (Y.K.), Institute of Development, Aging and Cancer, Tohoku University; Department of Neurology (M.K.), Tohoku Pharmaceutical University Hospital; Department of Neurology (O.T.), Sendai Medical Center; and Department of Neurology (A.T.), National Hospital Organization, Sendai Nishitaga Hospital, Sendai, Japan.
authors: Kazuhiko
authors: K
authors: Yanai
authors: From the Departments of Neurology (A.K., T.H., T.B., N.S., R.O., S.Y., J.K., M.E., M.A.), Pharmacology (N.O., R.H., K.Y.), and Diagnostic Radiology (S.M.), Tohoku University Graduate School of Medicine; Divisions of Cyclotron Nuclear Medicine (S.W., K.H., M.T.) and Radiopharmaceutical Chemistry (Y.F., R.I., S.F.), Cyclotron and Radioisotope Center, and Department of Geriatric and Respiratory Medicine (A.I., K.F., H.A.) and Division of Neuroimaging (Y.K.), Institute of Development, Aging and Cancer, Tohoku University; Department of Neurology (M.K.), Tohoku Pharmaceutical University Hospital; Department of Neurology (O.T.), Sendai Medical Center; and Department of Neurology (A.T.), National Hospital Organization, Sendai Nishitaga Hospital, Sendai, Japan.
authors: Yukitsuka
authors: Y
authors: Kudo
authors: From the Departments of Neurology (A.K., T.H., T.B., N.S., R.O., S.Y., J.K., M.E., M.A.), Pharmacology (N.O., R.H., K.Y.), and Diagnostic Radiology (S.M.), Tohoku University Graduate School of Medicine; Divisions of Cyclotron Nuclear Medicine (S.W., K.H., M.T.) and Radiopharmaceutical Chemistry (Y.F., R.I., S.F.), Cyclotron and Radioisotope Center, and Department of Geriatric and Respiratory Medicine (A.I., K.F., H.A.) and Division of Neuroimaging (Y.K.), Institute of Development, Aging and Cancer, Tohoku University; Department of Neurology (M.K.), Tohoku Pharmaceutical University Hospital; Department of Neurology (O.T.), Sendai Medical Center; and Department of Neurology (A.T.), National Hospital Organization, Sendai Nishitaga Hospital, Sendai, Japan.
authors: Atsushi
authors: A
authors: Takeda
authors: From the Departments of Neurology (A.K., T.H., T.B., N.S., R.O., S.Y., J.K., M.E., M.A.), Pharmacology (N.O., R.H., K.Y.), and Diagnostic Radiology (S.M.), Tohoku University Graduate School of Medicine; Divisions of Cyclotron Nuclear Medicine (S.W., K.H., M.T.) and Radiopharmaceutical Chemistry (Y.F., R.I., S.F.), Cyclotron and Radioisotope Center, and Department of Geriatric and Respiratory Medicine (A.I., K.F., H.A.) and Division of Neuroimaging (Y.K.), Institute of Development, Aging and Cancer, Tohoku University; Department of Neurology (M.K.), Tohoku Pharmaceutical University Hospital; Department of Neurology (O.T.), Sendai Medical Center; and Department of Neurology (A.T.), National Hospital Organization, Sendai Nishitaga Hospital, Sendai, Japan.
authors: Masashi
authors: M
authors: Aoki
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000000981:diagnostic imaging / Q000378:metabolism; D000631:Aminopyridines; D001345:Autoradiography; D001480:Basal Ganglia Diseases / Q000000981:diagnostic imaging* / Q000378:metabolism*; D015415:Biomarkers / Q000134:cerebrospinal fluid; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism*; D001931:Brain Mapping; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D008609:Mental Status Schedule; D008875:Middle Aged; D049268:Positron-Emission Tomography; D011804:Quinolines; D019275:Radiopharmaceuticals; D016875:tau Proteins / Q000378:metabolism*
chemical_list: D000631:Aminopyridines; D015415:Biomarkers; C054369:MAPT protein, human; D011804:Quinolines; D019275:Radiopharmaceuticals; C000608225:THK5351; D016875:tau Proteins