title: Impact of the Relationship of Stress and the Immune System in the Appearance of Alzheimer's Disease.
abstract: The understanding of how the immune system works, as well as its relationship with the stress level, seems to be important at the start of the Alzheimer's disease (AD). To analyze this, immunoglobulin A (IgA) and cortisol in saliva were measured using ELISA in patients with mild AD and healthy volunteers, and the production of both biomarkers was compared and correlated. In participants without AD, IgA was higher when cortisol was lower, and the opposite happened in participants with AD, with the quantification in saliva being a suitable method to determine it.
authors: Faculty of Dentistry, European University of Valencia, Valencia, Spain.
authors: Jose Enrique
authors: JE
authors: de la Rubia Ortí
authors: Faculty of Nursing, Catholic University of Valencia, Valencia, Spain.
authors: Sandra
authors: S
authors: Sancho Castillo
authors: Faculty of Nursing, Catholic University of Valencia, Valencia, Spain.
authors: Maria
authors: M
authors: Benlloch
authors: Faculty of Nursing and Podology, University of Valencia, Valencia, Spain.
authors: Mariano
authors: M
authors: Julián Rochina
authors: Faculty of Nursing and Podology, University of Valencia, Valencia, Spain.
authors: Silvia
authors: S
authors: Corchón Arreche
authors: Faculty of Psychology, European University of Valencia, Valencia, Spain.
authors: María Pilar
authors: MP
authors: García-Pardo
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000150:complications* / Q000276:immunology*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism; D007107:Immune System / Q000473:pathology*; D007070:Immunoglobulin A / Q000097:blood; D008297:Male; D012463:Saliva / Q000378:metabolism; D018709:Statistics, Nonparametric; D013315:Stress, Psychological / Q000209:etiology*
chemical_list: D007070:Immunoglobulin A; D006854:Hydrocortisone
keywords: Alzheimer’s disease; cortisol; immune system; immunoglobulin A; stress