title: Immune reconstitution inflammatory syndrome in HIV infection: taking the bad with the good.
abstract: In this review, we will describe the immunopathogies of immune reconstitution inflammatory syndrome, IRIS. IRIS occurs in a small subset of HIV patient, initiating combination antiretroviral therapy (ART), where immune reconstitution becomes dysregulated, resulting in an overly robust antigen-specific inflammatory reaction. We will discuss IRIS in terms of the associated coinfections: mycobacteria, cryptococci, and viruses.
authors: HIV Pathogenesis Section, Laboratory of Immunoregulation, NIAID/NIH, Bethesda, MD, USA.
authors: C-S
authors: CS
authors: Wong
authors: HIV Pathogenesis Section, Laboratory of Immunoregulation, NIAID/NIH, Bethesda, MD, USA.
authors: E S
authors: ES
authors: Richards
authors: HIV Pathogenesis Section, Laboratory of Immunoregulation, NIAID/NIH, Bethesda, MD, USA.
authors: L
authors: L
authors: Pei
authors: HIV Pathogenesis Section, Laboratory of Immunoregulation, NIAID/NIH, Bethesda, MD, USA.
authors: I
authors: I
authors: Sereti
mesh_terms: D019380:Anti-HIV Agents / Q000627:therapeutic use*; D060085:Coinfection / Q000276:immunology; D003453:Cryptococcosis / Q000276:immunology*; D003586:Cytomegalovirus Infections / Q000276:immunology; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology*; D006509:Hepatitis B / Q000276:immunology; D006566:Herpesviridae Infections / Q000276:immunology; D006801:Humans; D054019:Immune Reconstitution Inflammatory Syndrome / Q000276:immunology*; D015270:Mycobacterium avium-intracellulare Infection / Q000276:immunology; D014397:Tuberculosis, Pulmonary / Q000276:immunology*; D000073618:Varicella Zoster Virus Infection / Q000276:immunology
chemical_list: D019380:Anti-HIV Agents
keywords: 
  HIV
  ; coinfection; immune reconstitution; immunology; lymphopenia; microbiology