title: FutureTox III: Bridges for Translation.
abstract: Future Tox III, a Society of Toxicology Contemporary Concepts in Toxicology workshop, was held in November 2015. Building upon Future Tox I and II, Future Tox III was focused on developing the high throughput risk assessment paradigm and taking the science of in vitro data and in silico models forward to explore the question-what progress is being made to address challenges in implementing the emerging big-data toolbox for risk assessment and regulatory decision-making. This article reports on the outcome of the workshop including 2 examples of where advancements in predictive toxicology approaches are being applied within Federal agencies, where opportunities remain within the exposome and AOP domains, and how collectively the toxicology community across multiple sectors can continue to bridge the translation from historical approaches to Tox21 implementation relative to risk assessment and regulatory decision-making.
authors: Dow AgroSciences, Indianapolis, Indiana; drjuberg@dow.com.
authors: Daland R
authors: DR
authors: Juberg
authors: US Environmental Protection Agency, Research Triangle Park, North Carolina.
authors: Thomas B
authors: TB
authors: Knudsen
authors: Page One Editorial Services, Boulder, Colorado.
authors: Miriam
authors: M
authors: Sander
authors: American Chemistry Council, Washington, The District of Columbia.
authors: Nancy B
authors: NB
authors: Beck
authors: University of Washington, Seattle, Washington.
authors: Elaine M
authors: EM
authors: Faustman
authors: US Food and Drug Administration, Silver Spring, Maryland.
authors: Donna L
authors: DL
authors: Mendrick
authors: Science to Inform, LLC, Pittsboro, North Carolina.
authors: John R
authors: JR
authors: Fowle
authors: Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
authors: Thomas
authors: T
authors: Hartung
authors: National Toxicology Program/National Institute of Environmental Health Sciences, Durham, North Carolina.
authors: Raymond R
authors: RR
authors: Tice
authors: INERIS-Chronic Risk Division, Verneeuil-en-Halatte, France.
authors: Emmanuel
authors: E
authors: Lemazurier
authors: American Chemistry Council, Washington, The District of Columbia.
authors: Richard A
authors: RA
authors: Becker
authors: US Food and Drug Administration, College Park, Maryland.
authors: Suzanne Compton
authors: SC
authors: Fitzpatrick
authors: Procter & Gamble Company, Cincinnati, Ohio.
authors: George P
authors: GP
authors: Daston
authors: University of Arkansas for Medical Sciences, Little Rock, Arkansas.
authors: Alison
authors: A
authors: Harrill
authors: US Environmental Protection Agency, Research Triangle Park, North Carolina.
authors: Ronald N
authors: RN
authors: Hines
authors: Sanofi, Bridgewater, New Jersey.
authors: Douglas A
authors: DA
authors: Keller
authors: US Environmental Protection Agency, Cincinnati, Ohio.
authors: John C
authors: JC
authors: Lipscomb
authors: Lhasa Limited, Leeds, United Kingdom.
authors: David
authors: D
authors: Watson
authors: US Environmental Protection Agency, Washington, The District of Columbia.
authors: Tina
authors: T
authors: Bahadori
authors: US Environmental Protection Agency, Research Triangle Park, North Carolina.
authors: Kevin M
authors: KM
authors: Crofton
mesh_terms: D000818:Animals; D006801:Humans; D066298:In Vitro Techniques; D018675:Toxicity Tests; D014116:Toxicology
keywords: in vitro and alternatives; predictive toxicology; regulatory/policy; risk assessment; testing alternatives.