title: Risk of acute coronary syndrome after parathyroidectomy in patients with end-stage renal disease: A population-based cohort study in Taiwan.
abstract: OBJECTIVE
  Patients with end-stage renal disease (ESRD) who received parathyroidectomy (PTX) had persistently reduced levels of parathyroid hormone. This study investigated the risk of acute coronary syndrome (ACS) in patients with ESRD who underwent PTX using a nationwide health insurance claims database.
  
  
  METHODS
  Of all ESRD patients, we selected 1047 individuals who had undergone PTX between 2000 and 2008 as the PTX group and 4188 patients who did not undergo PTX (non-PTX group) matched by propensity score. Multivariable Cox proportional hazards regression analysis was conducted for assessing the excess ACS risk for the PTX group compared to the non-PTX group.
  
  
  RESULTS
  The mean follow-up periods were 4.63 and 4.04 years for the PTX and non-PTX groups, respectively. A significant reduction in the risk of ACS (adjusted hazard ratio = 0.74, 95% confidence interval = 0.57-0.96) was observed for the ESRD patients after PTX.
  
  
  CONCLUSIONS
  Parathyroidectomy is associated with reduced risk of ACS in patients with ESRD.
authors: Division of Nephrology, Department of Internal Medicine, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi, Taiwan.
authors: Tsung Liang
authors: http://orcid.org/0000-0002-4131-7966
authors: TL
authors: Ma
authors: Division of Cardiology, Department of Internal Medicine, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi, Taiwan.|Chung Jen Junior College of Nursing, Health Sciences and Management, Chiayi, Taiwan.|Department of Beauty and Health Care, Min-Hwei Junior College of Health Care Management, Tainan, Taiwan.
authors: Rei Yeuh
authors: RY
authors: Chang
authors: Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan.|Department of College of Medicine, China Medical University, Taichung, Taiwan.
authors: Hsuan Ju
authors: HJ
authors: Chen
authors: Department of Public Health and Department of Health Services Administration, China Medical University, Taichung, Taiwan.|Department of Education, China Medical University Hospital, Taichung, Taiwan.
authors: Chun Yi
authors: CY
authors: Liu
authors: Department of Health Services Administration, China Medical University, Taichung, Taiwan.|Institute of Population Health Sciences, National Health Research Institutes, Zhunane, Miaoli, Taiwan.
authors: Chih Cheng
authors: CC
authors: Hsu
authors: Division of Nephrology, Department of Internal Medicine, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi, Taiwan.|Department of Medical Research, China Medical University Hospital and China Medical University, Taichung, Taiwan.|Department of Nursing, Min-Hwei Junior College of Health Care Management, Tainan, Taiwan.
authors: Yueh Han
authors: YH
authors: Hsu
mesh_terms: D054058:Acute Coronary Syndrome / Q000175:diagnosis / Q000453:epidemiology / Q000517:prevention & control*; D000067575:Administrative Claims, Healthcare; D000293:Adolescent; D000328:Adult; D000368:Aged; D016208:Databases, Factual; D005260:Female; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000175:diagnosis / Q000453:epidemiology / Q000601:surgery*; D015994:Incidence; D007676:Kidney Failure, Chronic / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016105:Parathyroidectomy; D057216:Propensity Score; D016016:Proportional Hazards Models; D065840:Protective Factors; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D013624:Taiwan / Q000453:epidemiology; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult