title: MiR-106a: Promising biomarker for cancer.
abstract: MicroRNAs (miRNAs), which are characterized by highly conserved and small non-coding RNAs, have been a hot spot regarding biological processes such as cellular proliferation, apoptosis and metabolism as well as cellular differentiation, signal transduction and carcinogenesis. MiRNA-106a (miR-106a), a member of the miR-17 family, has been validated to be aberrantly regulated in the diversity of tumors. The purpose of this review is supposed to deliver an intricate overview of miR-106a, including its role in cell proliferation, apoptosis, cell cycle, invasion and metastasis, involvement in drug resistance as well as its interactions with the target proteins and signaling pathways involved.
authors: Jiangsu Key Laboratory of Biological Cancer Therapy, Xuzhou Medical University, 84 West Huaihai Road, Xuzhou, Jiangsu 221002, China.
authors: Yao-Jie
authors: YJ
authors: Pan
authors: Department of Pathology, Xuzhou Medical University, Xuzhou 221002, China.
authors: Ying
authors: Y
authors: Zhuang
authors: Jiangsu Key Laboratory of Biological Cancer Therapy, Xuzhou Medical University, 84 West Huaihai Road, Xuzhou, Jiangsu 221002, China; Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy, Xuzhou Medical University, Xuzhou, Jiangsu 221002, China; Center of Clinical Oncology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002, China. Electronic address: jnzheng@xzmc.edu.cn.
authors: Jun-Nian
authors: JN
authors: Zheng
authors: Department of Pathology, Xuzhou Medical University, Xuzhou 221002, China; Jiangsu Key Laboratory of Biological Cancer Therapy, Xuzhou Medical University, 84 West Huaihai Road, Xuzhou, Jiangsu 221002, China; Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy, Xuzhou Medical University, Xuzhou, Jiangsu 221002, China. Electronic address: dspei@xzmc.edu.cn.
authors: Dong-Sheng
authors: DS
authors: Pei
mesh_terms: D000818:Animals; D049109:Cell Proliferation; D019008:Drug Resistance, Neoplasm; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000032:analysis / Q000235:genetics* / Q000378:metabolism; D009361:Neoplasm Invasiveness / Q000235:genetics / Q000473:pathology; D009369:Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D015398:Signal Transduction
chemical_list: C542541:MIRN106 microRNA, human; D035683:MicroRNAs
keywords: Biomarker; Cancer; MiR-106a; MicroRNA; Oncogene