title: Cognitive functioning one month and one year following febrile status epilepticus.
abstract: The objective of this study was to determine early developmental and cognitive outcomes of children with febrile status epilepticus (FSE) one month and one year after FSE.
  
  
  
  One hundred ninety four children with FSE were evaluated on measures of cognition, receptive language, and memory as part of the FEBSTAT study and compared with 100 controls with simple febrile seizures (FSs).
  
  
  
  Children with FSE did not differ dramatically on tasks compared with FS controls at one month after FSE but demonstrated slightly weaker motor development (p=0.035) and receptive language (p=0.034) at one year after FSE. Performances were generally within the low average to average range. Within the FSE cohort, non-White children performed weaker on many of the tasks compared with Caucasian children. At the one-year visit, acute hippocampal T2 findings on MRI were associated with weaker receptive language skills (p=0.0009), and human herpes virus 6 or 7 (HHV6/7) viremia was associated with better memory performances (p=0.047).
  
  
  
  Febrile status epilepticus does not appear to be associated with significant cognitive impairment on early developmental measures, although there is a trend for possible receptive language and motor delay one year after FSE. Further follow-up, which is in progress, is necessary to track long-term cognitive functioning.
authors: Department of Neurology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, United States. Electronic address: eweiss@montefiore.org.
authors: Erica F
authors: EF
authors: Weiss
authors: Department of Neurology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, United States.
authors: David
authors: D
authors: Masur
authors: Department of Neurology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, United States; Department of Pediatrics, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, United States; Department of Epidemiology and Population Health, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, United States.
authors: Shlomo
authors: S
authors: Shinnar
authors: GH Sergievsky Center, Columbia University, New York, NY, United States; Department of Epidemiology, Columbia University, New York, NY, United States.
authors: Dale C
authors: DC
authors: Hesdorffer
authors: GH Sergievsky Center, Columbia University, New York, NY, United States; Department of Neurology, Columbia University, New York, NY, United States.
authors: Veronica J
authors: VJ
authors: Hinton
authors: Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, United States.
authors: Melanie
authors: M
authors: Bonner
authors: Department of Psychiatry and Behavioral Sciences, Northwestern University, Feinberg School of Medicine, Chicago, IL, United States.
authors: Julie
authors: J
authors: Rinaldi
authors: Department of Neurology, Children's Hospital of The King's Daughters and Eastern Virginia Medical School, Norfolk, VA, United States; Department of Pediatrics, Children's Hospital of The King's Daughters and Eastern Virginia Medical School, Norfolk, VA, United States.
authors: Virginia
authors: V
authors: Van de Water
authors: Department of Neurology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA, United States; Department of Psychiatry, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA, United States.
authors: James
authors: J
authors: Culbert
authors: Department of Neurology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, United States.
authors: Ruth C
authors: RC
authors: Shinnar
authors: Department of Neurology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA, United States.
authors: Syndi
authors: S
authors: Seinfeld
authors: Department of Pediatrics-Neurology, Duke University Medical Center, Durham, NC, United States.
authors: William
authors: W
authors: Gallentine
authors: Department of Neurology, Children's Hospital of Los Angeles, United States.
authors: Douglas R
authors: DR
authors: Nordli
authors: Department of Neurology, Children's Hospital of The King's Daughters and Eastern Virginia Medical School, Norfolk, VA, United States; Department of Pediatrics, Children's Hospital of The King's Daughters and Eastern Virginia Medical School, Norfolk, VA, United States.
authors: L Mathew
authors: LM
authors: Frank
authors: Department of Neurology, Ann & Robert H. Lurie Children's Hospital of Chicago, United States.
authors: Leon
authors: L
authors: Epstein
authors: Department of Neurology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, United States; Department of Pediatrics, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, United States; Department of Neuroscience, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, United States.
authors: Solomon L
authors: SL
authors: Moshé
authors: Department of Biostatistics, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA, United States.
authors: Shumei
authors: S
authors: Sun
mesh_terms: D002675:Child, Preschool; D003071:Cognition / Q000502:physiology*; D005260:Female; D006624:Hippocampus / Q000000981:diagnostic imaging; D006801:Humans; D007223:Infant; D007802:Language; D008279:Magnetic Resonance Imaging; D008297:Male; D008568:Memory / Q000502:physiology*; D059906:Neuroimaging; D009483:Neuropsychological Tests; D003294:Seizures, Febrile / Q000150:complications / Q000000981:diagnostic imaging / Q000523:psychology*; D013226:Status Epilepticus / Q000150:complications / Q000000981:diagnostic imaging / Q000523:psychology*
keywords: Children; Cognition; Febrile seizure; Febrile status epilepticus