title: Comparison of Hydrogel Produced by Radiation as Applied at the Research Center (Yazd Branch) With MaxGel and Routine Dressing for Second-Degree Burn Repair in Yazd Burn Hospital.
abstract: BACKGROUND
  Recently, the radiation application research center for the atomic energy organization of Yazd (Iran) has developed a hydrogel dressing which was evaluated for quality and safety in 2008. Its efficacy for assisting in the wound healing process was approved for animal use, and its use has proven to be more effective than a related Syrian material.
  
  
  OBJECTIVE
  We have already confirmed the safety and efficacy of Irgel use on mice (1, 2), so this study was conducted in order to further evaluate its effectiveness on human burn wounds, and to compare its efficacy with MaxGel, another hydrogel. A randomized clinical trial study was conducted to compare the efficacy of hydrogel produced by the radiation application research center (Yazd Branch) with MaxGel and routine dressing on burn repair in the Yazd Burn hospital.
  
  
  METHODS
  In this study, 90 patients with second-degree burn injuries who were admitted to the Yazd Burn hospital were randomly divided into three equal groups. In the negative control group, the wounds were covered with sterile vaseline gauze followed by double sterile dry gauze and ultimately bandaged. In the test group, the wounds were covered by an Iranian hydrogel sheet (Irgel) instead of vaseline gauze, while in the positive control group, the wounds were covered by MaxGel instead of Irgel. At each visit (every other day), each dressing was renewed by its respective method and the wound area, pain score, and body temperature were recorded. At the beginning and at the end of the first and second week, five milliliters of venous blood were taken from all patients to evaluate hematologic parameters such as peripheral blood cell count, liver function, blood urea nitrogen, and creatinine.
  
  
  RESULTS
  Before the intervention, the extent of the burns and pain sensations were quite similar among the different groups, but at the second week, the burn areas and pain scores for the Irgel group were significantly less than those of the normal control and the positive control groups (P < 0.05).
  
  
  CONCLUSIONS
  Based on our findings, both gels assist in the process of burn wound healing and pain reduction more effectively as compared with routine dressing. However, Irgel had better effects on wound healing and pain relief than MaxGel, which indicates a better quality of Irgel for this particular kind of treatment.
authors: Dermatology Department, Shahid Sadoughi University of Medical Sciences, Yazd, IR Iran.
authors: Mohammad Taghi
authors: MT
authors: Noorbala
authors: Dermatology Department, Shahid Sadoughi University of Medical Sciences, Yazd, IR Iran.
authors: Mohammad
authors: M
authors: Noorbala
authors: Physiology Department, Shahid Sadoughi University of Medical Sciencse, Yazd, IR Iran.
authors: Mohammad Hossein
authors: MH
authors: Dashti-Rahmatabadi
authors: Dermatology Department, Shahid Sadoughi University of Medical Sciences, Yazd, IR Iran.
authors: Mahdi
authors: M
authors: Noorbala
authors: Dermatology Department, Shahid Sadoughi University of Medical Sciences, Yazd, IR Iran.
authors: Roghaye
authors: R
authors: Noorbala
authors: Dermatology Department, Shahid Sadoughi University of Medical Sciences, Yazd, IR Iran.
authors: Behare
authors: B
authors: Mozaffary
keywords: Burn; Hydrogel; Iranian Gel; MaxGel