title: Neuroimmune interactions: dendritic cell modulation by the sympathetic nervous system.
abstract: Dendritic cells are of paramount importance bridging innate and adaptive immune responses. Depending on the context, after sensing environmental antigens, commensal microorganisms, pathogenic agents, or antigens from the diet, dendritic cells may drive either different effector adaptive immune responses or tolerance, avoiding tissue damage. Although the plasticity of the immune response and the capacity to regulate itself are considered essential to orchestrate appropriate physiological responses, it is known that the nervous system plays a relevant role controlling immune cell function. Dendritic cells present in the skin, the intestine, and lymphoid organs, besides expressing adrenergic receptors, can be reached by neurotransmitters released by sympathetic fibers innervating these tissues. These review focus on how neurotransmitters from the sympathetic nervous system can modulate dendritic cell function and how this may impact the immune response and immune-mediated disorders.
authors: Departamento de Microbiologia, Imunologia e Parasitologia, Escola Paulista de Medicina, Universidade Federal de São Paulo (UNIFESP), Rua Botucatu 862, Edifício de Ciências Biomédicas 4° andar, São Paulo, SP, 04023-062, Brazil.
authors: Maisa C
authors: MC
authors: Takenaka
authors: Departamento de Microbiologia, Imunologia e Parasitologia, Escola Paulista de Medicina, Universidade Federal de São Paulo (UNIFESP), Rua Botucatu 862, Edifício de Ciências Biomédicas 4° andar, São Paulo, SP, 04023-062, Brazil.
authors: Marcia G
authors: MG
authors: Guereschi
authors: Departamento de Microbiologia, Imunologia e Parasitologia, Escola Paulista de Medicina, Universidade Federal de São Paulo (UNIFESP), Rua Botucatu 862, Edifício de Ciências Biomédicas 4° andar, São Paulo, SP, 04023-062, Brazil. asbasso@unifesp.br.
authors: Alexandre S
authors: AS
authors: Basso
mesh_terms: D000818:Animals; D016207:Cytokines / Q000378:metabolism; D003713:Dendritic Cells / Q000276:immunology* / Q000378:metabolism*; D006801:Humans; D007107:Immune System / Q000166:cytology* / Q000502:physiology*; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000276:immunology / Q000294:innervation; D008221:Lymphoid Tissue / Q000276:immunology / Q000294:innervation / Q000378:metabolism; D015213:Neuroimmunomodulation; D009638:Norepinephrine / Q000378:metabolism; D011941:Receptors, Adrenergic / Q000378:metabolism; D015398:Signal Transduction; D012867:Skin / Q000276:immunology / Q000294:innervation / Q000378:metabolism; D013564:Sympathetic Nervous System / Q000502:physiology*
chemical_list: D016207:Cytokines; D011941:Receptors, Adrenergic; D009638:Norepinephrine
keywords: Cytokines; Dendritic cells; Neuroimmune interactions; Noradrenaline; Sympathetic nervous system