title: Differences in Type Composition of Symptom Clusters as Predictors of Quality of Life in Patients with Meningioma and Glioma.
abstract: OBJECTIVE
  Objectives of this study were to identify and compare symptom clusters in patients with meningioma and glioma and to assess and compare predictors of quality of life (QoL) in both patient groups.
  
  
  METHODS
  Data were collected using the MD Anderson Symptom Inventory-Brain Tumor Module, Functional Assessment of Cancer Therapy-General, and Karnofsky Performance Sale. Of 158 participating patients, 77 had meningioma, and 81 had glioma.
  
  
  RESULTS
  In patients with meningioma, 4 symptom clusters were identified with 55.4% total variance: 1) physical, 2) cognitive, 3) elimination-appearance, and 4) motor-sensory symptoms. In patients with glioma, 4 clusters with 67.3% total variance were identified: 1) treatment-related, 2) cognitive, 3) appearance-elimination, and 4) gastrointestinal symptoms. Predictors of QoL in patients with meningioma were Karnofsky Performance Scale score (β = 0.41, P < 0.001), cognitive symptom cluster (β = -0.36, P < 0.001), and physical symptom cluster (β = -0.32, P = 0.001), whereas treatment-related symptom cluster (β = -0.55, P < 0.001) was identified as a predictor of QoL in patients with glioma.
  
  
  CONCLUSIONS
  In this study, the type and composition of symptom clusters differed between patients with meningioma and glioma. Our data also provide evidence that even when participants reported mild symptoms, these clusters could be used to predict QoL in patients with meningioma and glioma.
authors: College of Nursing, Chonbuk National University, Jeollabuk-do, Korea.
authors: Sung Reul
authors: SR
authors: Kim
authors: College of Nursing, Hanyang University, Seoul, Korea. Electronic address: ysshin2k@hanyang.ac.kr.
authors: Yong Soon
authors: YS
authors: Shin
authors: Department of Neurosurgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors: Jeong Hoon
authors: JH
authors: Kim
authors: Department of Nursing, Asan Medical Center, Seoul, Korea.
authors: Minseon
authors: M
authors: Choi
authors: College of Nursing, Chonnam National University, Gwangju, Korea.
authors: Sung-Hee
authors: SH
authors: Yoo
mesh_terms: D000328:Adult; D001932:Brain Neoplasms / Q000150:complications / Q000523:psychology*; D016000:Cluster Analysis; D003071:Cognition / Q000502:physiology; D015444:Exercise / Q000502:physiology; D005260:Female; D005767:Gastrointestinal Diseases / Q000209:etiology; D005910:Glioma / Q000150:complications / Q000523:psychology*; D006801:Humans; D017567:Karnofsky Performance Status; D008297:Male; D008577:Meningeal Neoplasms / Q000150:complications / Q000523:psychology*; D008579:Meningioma / Q000150:complications / Q000523:psychology*; D008875:Middle Aged; D011788:Quality of Life / Q000523:psychology*; D011795:Surveys and Questionnaires; D055815:Young Adult
keywords: Glioma; Meningioma; Quality of life; Symptom cluster