title: Multifunctional magnetic nanostructured hardystonite scaffold for hyperthermia, drug delivery and tissue engineering applications.
abstract: Hyperthermia and local drug delivery have been proposed as potential therapeutic approaches for killing cancer cells. The development of bioactive materials such as Hardystonite (HT) with magnetic and drug delivery properties can potentially meet this target. This new class of magnetic bioceramic can replace the widely used magnetic iron oxide nanoparticles, whose long-term biocompatibility is not clear. Magnetic HT can be potentially employed to develop new ceramic scaffolds for bone surgery and anticancer therapies. With this in mind, a synthesis procedure was developed to prepare multifunctional bioactive scaffold for tissue engineering, hyperthermia and drug delivery applications. To this end, iron (Fe3+)-containing HT scaffolds were prepared. The effect of Fe on biological, magnetic and drug delivery properties of HT scaffolds were investigated. The results showed that obtained Fe-HT is bioactive and magnetic with no magnetite or maghemite as secondary phases. The Fe-HT scaffolds obtained also possessed high specific surface areas and demonstrated sustained drug delivery. These results potentially open new aspects for biomaterials aimed at regeneration of large-bone defects caused by malignant bone tumors through a combination of hyperthermia, local drug delivery and osteoconductivity.
authors: Department of Materials Engineering, Isfahan University of Technology, Isfahan 8415683111, Iran. Electronic address: a.farzin@ma.iut.ac.ir.
authors: Ali
authors: A
authors: Farzin
authors: Department of Materials Engineering, Isfahan University of Technology, Isfahan 8415683111, Iran; Dental Materials Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
authors: Mohammadhossein
authors: M
authors: Fathi
authors: Department of Materials Engineering, Isfahan University of Technology, Isfahan 8415683111, Iran.
authors: Rahmatollah
authors: R
authors: Emadi
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry; D001859:Bone Neoplasms / Q000188:drug therapy; D002516:Ceramics / Q000737:chemistry*; D002945:Cisplatin / Q000494:pharmacology / Q000627:therapeutic use; D019245:Compressive Strength; D016503:Drug Delivery Systems; D065546:Drug Liberation; D055119:Elastic Modulus; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006979:Hyperthermia, Induced; D007501:Iron; D008280:Magnetics; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure; D016062:Porosity; D011208:Powders; D017640:Silicates / Q000737:chemistry*; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds / Q000737:chemistry*; D014961:X-Ray Diffraction
chemical_list: D001672:Biocompatible Materials; D011208:Powders; D017640:Silicates; C000617419:hardystonite; D007501:Iron; D002945:Cisplatin
keywords: Drug delivery; Hyperthermia; Magnetic ceramic scaffolds