title: Outside the mainstream: novel collecting duct proteins regulating water balance.
abstract: Body water balance is critical to survival and, therefore, very tightly regulated by the hypothalamus and kidney. A key mechanism involved in this process, the arginine vasopressin-mediated phosphorylation and apical membrane insertion of aquaporin 2 in the collecting duct, has been extensively studied; however, with the increased availability of conditional knockout animals, several novel collecting duct proteins have recently been implicated in water homeostasis. In this Mini-Review, we briefly discuss these novel proteins and their roles in the regulation of water homeostasis.
authors: Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, Nebraska.
authors: Shamma S
authors: SS
authors: Rahman
authors: Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, Nebraska erika.boesen@unmc.edu.
authors: Erika I
authors: EI
authors: Boesen
mesh_terms: D000818:Animals; D020346:Aquaporins / Q000378:metabolism*; D001834:Body Water / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D007685:Kidney Tubules, Collecting / Q000378:metabolism*; D014882:Water-Electrolyte Balance
chemical_list: D020346:Aquaporins
keywords: aquaporin 2; collecting duct; water homeostasis