title: The evidence for microbiome manipulation in inflammatory arthritis.
abstract: The human body consists of millions of commensal bacteria (the microbiome), with the intestinal tract being the most prevalent site of colonization. This colonization process begins at birth, and despite numerous factors such as ageing, diet and drug use affecting the microbiome make-up, by adulthood the composition of the gut bacteria is relatively consistent across local populations. The recent advent of new scientific techniques has enabled us to explore how the microbiome affects health and, in particular, has shed light on the involvement of the microbiome in the pathogenesis of inflammatory disease. In this review we highlight the current evidence for microbiome manipulation in inflammatory arthritis in animal and human models and discuss potential therapeutics targeting the microbiome as treatment for these diseases.
authors: Rheumatology Department, Wexham Park Hospital, Slough.
authors: Hannah
authors: H
authors: Jethwa
authors: NIHR/Wellcome Trust Imperial Clinical Research Facility, Imperial College London, Hammersmith Hospital, London, UK.
authors: Sonya
authors: S
authors: Abraham
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001168:Arthritis / Q000188:drug therapy / Q000382:microbiology*; D015535:Arthritis, Psoriatic / Q000188:drug therapy / Q000382:microbiology; D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000382:microbiology; D001419:Bacteria / Q000302:isolation & purification; D064806:Dysbiosis / Q000150:complications / Q000188:drug therapy; D000069196:Gastrointestinal Microbiome / Q000187:drug effects; D006801:Humans; D019936:Probiotics / Q000627:therapeutic use; D025241:Spondylarthritis / Q000188:drug therapy / Q000382:microbiology; D013167:Spondylitis, Ankylosing / Q000188:drug therapy / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents
keywords: ankylosing spondylitis; bacteria; dysbiosis; inflammatory arthritis; microbiome; psoriatic arthritis; rheumatoid arthritis; spondyloarthritis