title: Clinical analysis of HIV/AIDS patients with drug eruption in Yunnan, China.
abstract: Drug eruption is the most common clinical presentation in patients with HIV/AIDS. The systemic clinical and risk factors associated with drug eruption remain unknown. A retrospective analysis in HIV/AIDS patients with drug eruption was carried out with demographic data, epidemiological data, clinical characteristics, laboratory data and follow-up data. The risk factors correlated with prognosis were assessed by case control analysis. A total of 134 out of 1817 HIV/AIDS patients (7.4%) presented drug eruptions. The major class of sensitizing drug was HAART drugs (47.7%), followed by antibiotics (47.0%). Nevirapine (39.6%) was the most common sensitizing drug in the HAART regimens. The patients received HAART or had allergic history were prone to develop drug eruption. The alanine aminotransferase, albumin, globulin, creatinine, blood urea nitrogen (BUN), lymphocytes, red blood cells (RBC) and eosinophils of the drug eruption patients were significantly different the control patients. The allergic history, opportunistic infection, viral load, CD4 cell count, high globulin and low albumin were the risk factors correlated with death in HIV/AIDS patients with drug eruption. It is proposed that patients with higher viral loads, higher globulin levels and lower white blood cells (WBC) should be given special attention for the prevention of complications and death.
authors: Department of Dermatology and Venerology, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, P. R. China.
authors: Yu-Ye
authors: YY
authors: Li
authors: Department of Dermatology and Venerology, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, P. R. China.|Department of HIV/AIDS, The Third People's Hospital of Kunming, Kunming 650041, P. R. China.
authors: Yong-Mei
authors: YM
authors: Jin
authors: School of Public Health, Kunming Medical University, Kunming 650500, P. R. China.
authors: Li-Ping
authors: LP
authors: He
authors: Department of HIV/AIDS, The Third People's Hospital of Kunming, Kunming 650041, P. R. China.
authors: Jin-Song
authors: JS
authors: Bai
authors: Department of HIV/AIDS, The Third People's Hospital of Kunming, Kunming 650041, P. R. China.
authors: Jun
authors: J
authors: Liu
authors: Department of HIV/AIDS, The Third People's Hospital of Kunming, Kunming 650041, P. R. China.
authors: Min
authors: M
authors: Yu
authors: Department of HIV/AIDS, The Third People's Hospital of Kunming, Kunming 650041, P. R. China.
authors: Jian-Hua
authors: JH
authors: Chen
authors: Center for Translational Medicine, Huaihe Clinical College, Henan University, Kaifeng 475000, P. R. China.|Pharmaceutical College, Henan University, Kaifeng 475001, P. R. China.
authors: Jing
authors: J
authors: Wen
authors: Center for Translational Medicine, Huaihe Clinical College, Henan University, Kaifeng 475000, P. R. China.
authors: Yi-Qun
authors: YQ
authors: Kuang
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy* / Q000378:metabolism / Q000821:virology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects*; D018791:CD4 Lymphocyte Count; D002681:China / Q000453:epidemiology; D003875:Drug Eruptions / Q000453:epidemiology* / Q000209:etiology / Q000378:metabolism; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000378:metabolism / Q000821:virology; D006801:Humans; D008297:Male; D008875:Middle Aged; D019829:Nevirapine / Q000009:adverse effects*; D012189:Retrospective Studies; D012712:Serum Globulins / Q000378:metabolism; D019562:Viral Load
chemical_list: D012712:Serum Globulins; D019829:Nevirapine