title: Comparison of the expression and function of Lin28A and Lin28B in colon cancer.
abstract: Lin28A and Lin28B are highly conserved RNA binding proteins with similar structure and functions. Recent studies demonstrated that both of them act as oncogenes and promote cancer progression. However, few researches compared the expression and functions of both oncogenes in human malignant tumors at same time. Additionally, although the expression and role of Lin28B in colon cancer is frequently reported, the expression and functions of Lin28A in colon cancer are largely unknown. In this study, we have systematically evaluated the expressional pattern, mutation status and correlation of both Lin28A and Lin28B in colon cancer tissues for the first time, and compared the roles of Lin28A and Lin28B in the proliferation, migration, invasion and apoptosis of colon cancer cells in vitro. We have showed that they are co-expressed and have functional similarities, however, the molecular mechanisms underlying their similar functions may not be identical. This study contributes to clarify the similarities and differences of Lin28A and Lin28B in colon cancer progression.
authors: Department of Pathology, Harbin Medical University, Harbin, China.
authors: Tianzhen
authors: T
authors: Wang
authors: Department of Pathology, Harbin Medical University, Harbin, China.
authors: Yan
authors: Y
authors: He
authors: Department of Gastrointestinal Medical Oncology, the Affiliated Tumor Hospital of Harbin Medical University, Harbin, China.
authors: Yuanyuan
authors: Y
authors: Zhu
authors: Department of Anatomy, Harbin Medical University, Harbin, China.
authors: Mingwei
authors: M
authors: Chen
authors: Department of Pathology, Harbin Medical University, Harbin, China.
authors: Mingjiao
authors: M
authors: Weng
authors: Department of Pathology, Harbin Medical University, Harbin, China.
authors: Chao
authors: C
authors: Yang
authors: Department of Nutrition and Food Hygiene, Public Health College, Harbin Medical University, Harbin, China.
authors: Yan
authors: Y
authors: Zhang
authors: Department of Gastrointestinal Surgery, International Hospital of Pecking University, Beijing, China.
authors: Ning
authors: N
authors: Ning
authors: Department of Pathology, Harbin Medical University, Harbin, China.
authors: Ran
authors: R
authors: Zhao
authors: Department of Pathology, Harbin Medical University, Harbin, China.
authors: Weiwei
authors: W
authors: Yang
authors: Department of Pathology, Harbin Medical University, Harbin, China.
authors: Yinji
authors: Y
authors: Jin
authors: Department of Pathology, Harbin Medical University, Harbin, China.
authors: Jing
authors: J
authors: Li
authors: Department of Pathology, Harbin Medical University, Harbin, China.
authors: Riju James Rajkumar Ezakiel
authors: RJ
authors: Redpath
authors: Department of Pathology, Harbin Medical University, Harbin, China.
authors: Lei
authors: L
authors: Zhang
authors: Department of Pathology, Harbin Medical University, Harbin, China.
authors: Xiaoming
authors: X
authors: Jin
authors: Department of Microbiology, Harbin Medical University, Harbin, China.
authors: Zhaohua
authors: Z
authors: Zhong
authors: Department of Microbiology, Harbin Medical University, Harbin, China.
authors: Fengmin
authors: F
authors: Zhang
authors: Department of General Surgery, the First Affiliated Hospital of Harbin Medical University, Harbin, China.
authors: Yunwei
authors: Y
authors: Wei
authors: Department of Medical Genetics, Medical College, Henan University of Science and Technology, Luoyang, China.
authors: Guomin
authors: G
authors: Shen
authors: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
authors: Dong
authors: D
authors: Wang
authors: Department of Nutrition and Food Hygiene, Public Health College, Harbin Medical University, Harbin, China.
authors: Ying
authors: Y
authors: Liu
authors: Department of Gastrointestinal Medical Oncology, the Affiliated Tumor Hospital of Harbin Medical University, Harbin, China.
authors: Guangyu
authors: G
authors: Wang
authors: Department of Pathology, Harbin Medical University, Harbin, China.|The Northern Medicine Translational Center, Heilongjiang Province Academy of Medical Science, Harbin, China.
authors: Xiaobo
authors: X
authors: Li
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000964:Antimetabolites, Antineoplastic / Q000494:pharmacology; D017209:Apoptosis; D002465:Cell Movement; D049109:Cell Proliferation; D003110:Colonic Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D018450:Disease Progression; D004305:Dose-Response Relationship, Drug; D005472:Fluorouracil / Q000494:pharmacology; D015972:Gene Expression Regulation, Neoplastic; D045325:HCT116 Cells; D006801:Humans; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D016601:RNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D014162:Transfection
chemical_list: D000964:Antimetabolites, Antineoplastic; C516326:LIN28B protein, human; D016601:RNA-Binding Proteins; D005472:Fluorouracil
keywords: Lin28A; Lin28B; colon cancer