title: Local Efficacy and Survival after Microwave Ablation of Lung Tumors: A Retrospective Study in 183 Patients.
abstract: OBJECTIVE
  To retrospectively evaluate local efficacy and survival after microwave (MW) ablation of lung tumors and identify predictors of prognosis.
  
  
  METHODS
  Data from 183 consecutive patients (67 women; mean age, 61.5 y ± 13.4) with lung tumors who had undergone 203 lung MW ablation sessions from January 2011 to May 2013 were assessed. The χ2test, independent-samples t test, Kaplan-Meier analysis, and Cox regression model analysis were used to estimate survival rates and evaluate significance of factors affecting rates of incomplete ablation, local progression, remote progression-free survival (RPFS), and cancer-specific survival (CSS).
  
  
  RESULTS
  Technical success rate was 100%. Incomplete ablation rate after 183 first MW ablations was 14.2% (26 of 183); maximum diameter of target tumors (P = .00001) was associated with incomplete ablation on univariate analysis. The local progression rate was 19.1% (35 of 183); emphysema (P = .020) and maximum diameter of target tumor (P = .000003) were associated with local progression. Median and 4-year RPFS were 15.0 months (95% confidence interval [CI], 11.1-18.9 mo) and 23.8%, respectively. Tumor stage (P < .01) and incomplete ablation (P = .002) were independent predictors of RPFS. Median and 4-year CSS were 24.9 months (95% CI, 19.9-29.9 mo) and 31.1%, respectively. Median and 4-year overall survival were 23.7 months (95% CI, 20.6-26.8 mo) and 29.6%, respectively. Tumor stage (P < .01) and maximum diameter (P = .009) were independent risk factors for CSS.
  
  
  CONCLUSIONS
  MW ablation is effective for lung tumors, especially small lesions of early-stage primary lung cancer and solitary lung metastasis.
authors: Departments of Oncology, Shandong Provincial Hospital Affiliated to Shandong University, 324 Jingwu Rd., Jinan 250021, China. Electronic address: am-zheng@163.com.
authors: Aimin
authors: A
authors: Zheng
authors: Departments of Oncology, Shandong Provincial Hospital Affiliated to Shandong University, 324 Jingwu Rd., Jinan 250021, China.
authors: Xin
authors: X
authors: Ye
authors: Departments of Oncology, Shandong Provincial Hospital Affiliated to Shandong University, 324 Jingwu Rd., Jinan 250021, China.
authors: Xia
authors: X
authors: Yang
authors: Departments of Oncology, Shandong Provincial Hospital Affiliated to Shandong University, 324 Jingwu Rd., Jinan 250021, China.
authors: Guanghui
authors: G
authors: Huang
authors: Radiology, Shandong Provincial Hospital Affiliated to Shandong University, 324 Jingwu Rd., Jinan 250021, China.
authors: Yonghao
authors: Y
authors: Gai
mesh_terms: D055011:Ablation Techniques / Q000009:adverse effects; D000368:Aged; D016009:Chi-Square Distribution; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008175:Lung Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D008297:Male; D008872:Microwaves / Q000009:adverse effects / Q000627:therapeutic use*; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome; D047368:Tumor Burden