title: PECAM-1gene polymorphism (rs668) and subclinical markers of carotid atherosclerosis in patients with type 2 diabetes mellitus.
abstract: The platelet endothelial cell adhesion molecule 1 (PECAM-1) plays an important role in many inflammatory processes, including the development of atherosclerosis. Polymorphism rs668 of thePECAM-1gene (373C/G) is functional, and it was reported to be associated with increased serum levels of PECAM-1. We investigated the association between the rs668 polymorphism of PECAM-1 and subclinical markers of carotid atherosclerosis in subjects with type 2 diabetes mellitus (T2DM). Five hundred and ninety-five T2DM subjects and 200 control subjects were enrolled. The carotid intima-media thickness (CIMT) and plaque characteristics (presence and structure) were assessed ultrasonographically. Biochemical analyses were performed using standard biochemical methods. Geno-typing of thePECAM-1gene polymorphism (rs668) was performed using KASPar assays. The control examinations were performed 3.8 ± 0.5 years after the initial examination. Higher CIMT was found in patients with T2DM in comparison with subjects without T2DM. Statistically sig-nificantly faster progression of the atherosclerotic markers was shown in subjects with T2DM in comparison with the control group. When adjusted to other risk factors, the rs668 GG genotype was associated with an increased risk of carotid plaques in subjects with T2DM. We concluded that our study demonstrated a minor effect of the rs668 PECAM-1 on markers of carotid atherosclerosis in subjects with T2DM.
authors: General Hospital Rakican, Murska Sobota, Slovenia.
authors: D
authors: D
authors: Popović
authors: Institute of Histology and Embryology, Faculty of Medicine, University in Ljubljana, Ljubljana, Slovenia.
authors: J
authors: J
authors: Nikolajević Starčević
authors: General Hospital Rakican, Murska Sobota, Slovenia.
authors: M
authors: M
authors: Šantl Letonja
authors: General Hospital Slovenj Gradec, Slovenj Gradec, Slovenia.
authors: J
authors: J
authors: Makuc
authors: General Hospital Slovenj Gradec, Slovenj Gradec, Slovenia.
authors: A
authors: A
authors: Cokan Vujkovac
authors: Zdravstveni Zavod Reschner, Ljubljana, Slovenia.
authors: H
authors: H
authors: Reschner
authors: General Hospital Rakican, Murska Sobota, Slovenia.
authors: D
authors: D
authors: Bregar
authors: D
authors: D
authors: Petrovič
keywords: Association study; Platelet endothelial cell adhesion molecule 1 (PECAM-1); carotid atherosclerosis; rs668 polymorphism; type 2 diabetes mellitus (T2DM)