title: Erythropoiesis provides a BRD's eye view of BET protein function.
abstract: Pharmacologic inhibitors of the bromodomain and extra-terminal motif (BET) protein family are in clinical trials for the treatment of hematologic malignancies, yet the functions of individual BET proteins remain largely uncharacterized. We review the molecular roles of BETs in the context of erythropoiesis. Studies in this lineage have provided valuable insights into their mechanisms of action, and helped define the individual and overlapping functions of BET protein family members BRD2, BRD3, and BRD4. These studies have important ramifications for our understanding of the molecular and physiologic roles of BET proteins, and provide a framework for elucidating some of the beneficial and adverse effects of pharmacologic inhibitors.
authors: Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA, United States.
authors: Aaron J
authors: AJ
authors: Stonestrom
authors: Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA, United States.
authors: Sarah C
authors: SC
authors: Hsu
authors: Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA, United States.
authors: Michael T
authors: MT
authors: Werner
authors: Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA, United States. Electronic address: Blobel@chop.edu.
authors: Gerd A
authors: GA
authors: Blobel
mesh_terms: D000818:Animals; D002843:Chromatin / Q000378:metabolism; D004920:Erythropoiesis / Q000502:physiology*; D006801:Humans; D009687:Nuclear Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism*; D000072417:Protein Domains; D014157:Transcription Factors / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism*
chemical_list: D002843:Chromatin; D009687:Nuclear Proteins; D014157:Transcription Factors