title: SORL1 rs1699102 polymorphism modulates age-related cognitive decline and gray matter volume reduction in non-demented individuals.
abstract: SORL1 rs1699102 is associated with the risk of late-onset Alzheimer's disease. However, the effects of this single nucleotide polymorphism on cognition and brain structure during normal aging are unclear. This study aimed to examine the effects of the rs1699102 polymorphism on age-related cognitive decline and cortical gray matter reduction in the Chinese Han population.
  
  
  
  A total of 780 non-demented adults completed a battery of neuropsychological tests. High-resolution T1-weighted structural magnetic resonance imaging data from 89 of these subjects were also collected using a Siemens Trio 3.0 Tesla scanner.
  
  
  
  The T allele carriers displayed an accelerated age-related change in episodic memory and processing speed tests relative to the CC genotype. A similar pattern was observed in the age-related gray matter volume (GMV) reduction of the right middle temporal pole. The GMV in this region was significantly positively correlated with the episodic memory scores.
  
  
  
  The SORL1 gene rs1699102 polymorphism has been found to be associated with age-related cognitive decline and GMV reduction of the right middle temporal pole in older adults. These findings elucidate how the SORL1 variants shape the neural system to modulate age-related cognitive decline and support the hypothesis that SORL1 may represent a candidate gene for late-onset Alzheimer's disease.
authors: Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, P.R. China.|BABRI Centre, Beijing Normal University, Beijing, P. R. China.
authors: He
authors: H
authors: Li
authors: Consulting Center of Biomedical Statistics, Academy of Military Medical Sciences, Beijing, P. R. China.
authors: Chenlong
authors: C
authors: Lv
authors: State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, P. R. China.|BABRI Centre, Beijing Normal University, Beijing, P. R. China.
authors: Caishui
authors: C
authors: Yang
authors: Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, P.R. China.|BABRI Centre, Beijing Normal University, Beijing, P. R. China.
authors: Dongfeng
authors: D
authors: Wei
authors: Computational Image Analysis Banner Alzheimer's Institute, Phoenix, AZ, USA.
authors: Kewei
authors: K
authors: Chen
authors: Dept of Functional Neuroimaging, Beijing Neurosurgical Institute, Beijing, P. R. China.
authors: Shaowu
authors: S
authors: Li
authors: State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, P. R. China.|BABRI Centre, Beijing Normal University, Beijing, P. R. China.
authors: Zhanjun
authors: Z
authors: Zhang
mesh_terms: D000368:Aged; D000375:Aging; D000483:Alleles; D001921:Brain / Q000000981:diagnostic imaging* / Q000473:pathology; D003071:Cognition / Q000502:physiology*; D060825:Cognitive Dysfunction / Q000000981:diagnostic imaging / Q000235:genetics* / Q000473:pathology; D005260:Female; D005838:Genotype; D066128:Gray Matter / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D026502:LDL-Receptor Related Proteins / Q000235:genetics*; D008279:Magnetic Resonance Imaging; D008297:Male; D026901:Membrane Transport Proteins / Q000235:genetics*; D008875:Middle Aged; D009483:Neuropsychological Tests; D009929:Organ Size / Q000235:genetics; D020641:Polymorphism, Single Nucleotide
chemical_list: D026502:LDL-Receptor Related Proteins; D026901:Membrane Transport Proteins; C102582:SORL1 protein, human
keywords: 
  SORL1
  ; chinese; cognitive decline; gray matter volume; non-demented elderly