title: HMGB2 holds the key to the senescence-associated secretory phenotype.
abstract: The senescence-associated secretory phenotype (SASP) is a hallmark of senescence with an important physiological impact, but how it is established is unclear. In this issue, Aird et al. (2016. J. Cell Biol. https://doi.org/10.1083/jcb.201608026) describe how chromatin-bound HMGB2 fine tunes SASP expression by avoiding heterochromatin spreading.
authors: Medical Research Council Clinical Sciences Centre, W12 0NN London, England, UK.|Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, W12 0NN London, England, UK.
authors: Ana
authors: A
authors: Guerrero
authors: Medical Research Council Clinical Sciences Centre, W12 0NN London, England, UK jesus.gil@csc.mrc.ac.uk.|Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, W12 0NN London, England, UK.
authors: Jesús
authors: J
authors: Gil
mesh_terms: D059447:Cell Cycle Checkpoints; D016922:Cellular Senescence; D002843:Chromatin; D015536:Down-Regulation; D024261:HMGB2 Protein / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D010641:Phenotype; D055571:Secretory Pathway
chemical_list: D002843:Chromatin; D024261:HMGB2 Protein