title: Early satiety and postprandial fullness in gastroparesis correlate with gastroparesis severity, gastric emptying, and water load testing.
abstract: BACKGROUND
  Early satiety (ES) and postprandial fullness (PPF) are often present in gastroparesis, but the importance of these symptoms in gastroparesis has not been well-described. The aims were: (i) Characterize ES and PPF in patients with gastroparesis. (ii) Assess relationships of ES and PPF with etiology of gastroparesis, quality of life, body weight, gastric emptying, and water load testing.
  
  
  METHODS
  Gastroparetic patients filled out questionnaires assessing symptoms (PAGI-SYM) and quality of life (PAGI-QOL, SF-36v2). Patients underwent gastric emptying scintigraphy and water load testing.
  
  
  RESULTS
  198 patients with gastroparesis (134 IG, 64 DG) were evaluated. Early satiety was severe or very severe in 50% of patients. Postprandial fullness was severe or very severe in 60% of patients. Severity scores for ES and PPF were similar between idiopathic and diabetic gastroparesis. Increasing severity of ES and PPF were associated with other gastroparesis symptoms including nausea/vomiting, satiety/early fullness, bloating, and upper abdominal pain and GERD subscores. Increasing severity of ES and PPF were associated with increasing gastroparesis severity, decreased BMI, decreased quality of life from PAGI-QOL and SF-36 physical health. Increasing severity of ES and PPF were associated with increasing gastric retention of a solid meal and decreased volume during water load test.
  
  
  CONCLUSIONS
  Early satiety and PPF are commonly severe symptoms in both diabetic and idiopathic gastroparesis. Early satiety and PPF severity are associated with other gastroparesis symptom severities, body weight, quality of life, gastric emptying, and water load testing. Thus, ES and PPF are important symptoms characterizing gastroparesis. ClinicalTrials.gov number: NCT NCT01696747.
authors: Temple University, Philadelphia, PA, USA.
authors: H P
authors: HP
authors: Parkman
authors: Johns Hopkins University, Baltimore, MD, USA.
authors: E K
authors: EK
authors: Hallinan
authors: University of Michigan, Ann Arbor, MI, USA.
authors: W L
authors: WL
authors: Hasler
authors: Mayo Clinic, Rochester, MN, USA.
authors: G
authors: G
authors: Farrugia
authors: Wake Forest University, Winston-Salem, NC, USA.
authors: K L
authors: KL
authors: Koch
authors: Stanford University, Palo Alto, CA, USA.
authors: L
authors: L
authors: Nguyen
authors: California Pacific Medical Center, San Francisco, CA, USA.
authors: W J
authors: WJ
authors: Snape
authors: University of Louisville, Louisville, KY, USA.
authors: T L
authors: TL
authors: Abell
authors: Texas Tech University, El paso, TX, USA.
authors: R W
authors: RW
authors: McCallum
authors: Texas Tech University, El paso, TX, USA.
authors: I
authors: I
authors: Sarosiek
authors: Johns Hopkins University, Baltimore, MD, USA.
authors: P J
authors: PJ
authors: Pasricha
authors: Johns Hopkins University, Baltimore, MD, USA.
authors: J
authors: http://orcid.org/0000-0003-2625-1169
authors: J
authors: Clarke
authors: Johns Hopkins University, Baltimore, MD, USA.
authors: L
authors: L
authors: Miriel
authors: Johns Hopkins University, Baltimore, MD, USA.
authors: J
authors: J
authors: Tonascia
authors: National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA.
authors: F
authors: F
authors: Hamilton
mesh_terms: D000328:Adult; D004326:Drinking / Q000502:physiology*; D005260:Female; D005746:Gastric Emptying / Q000502:physiology*; D018589:Gastroparesis / Q000175:diagnosis / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D019518:Postprandial Period / Q000502:physiology*; D011446:Prospective Studies; D012042:Registries; D012528:Satiety Response / Q000502:physiology*; D012720:Severity of Illness Index
keywords: diabetic gastroparesis; early satiety; gastric emptying; gastroparesis