title: Nanofabricated Neural Probes for Dense 3-D Recordings of Brain Activity.
abstract: Computations in brain circuits involve the coordinated activation of large populations of neurons distributed across brain areas. However, monitoring neuronal activity in the brain of intact animals with high temporal and spatial resolution has remained a technological challenge. Here we address this challenge by developing dense, three-dimensional (3-D) electrode arrays for electrophysiology. The 3-D arrays constitute the front-end of a modular and configurable system architecture that enables monitoring neuronal activity with unprecedented scale and resolution.
authors: Division of Biology and Biological Engineering, ‡Division of Engineering and Applied Science, §Division of Physics, Mathematics, and Astronomy, and ∥Kavli Nanoscience Institute, California Institute of Technology , Pasadena, California 91125, United States.
authors: Gustavo
authors: G
authors: Rios
authors: Division of Biology and Biological Engineering, ‡Division of Engineering and Applied Science, §Division of Physics, Mathematics, and Astronomy, and ∥Kavli Nanoscience Institute, California Institute of Technology , Pasadena, California 91125, United States.
authors: Evgueniy V
authors: EV
authors: Lubenov
authors: Division of Biology and Biological Engineering, ‡Division of Engineering and Applied Science, §Division of Physics, Mathematics, and Astronomy, and ∥Kavli Nanoscience Institute, California Institute of Technology , Pasadena, California 91125, United States.
authors: Derrick
authors: D
authors: Chi
authors: Division of Biology and Biological Engineering, ‡Division of Engineering and Applied Science, §Division of Physics, Mathematics, and Astronomy, and ∥Kavli Nanoscience Institute, California Institute of Technology , Pasadena, California 91125, United States.
authors: Michael L
authors: ML
authors: Roukes
authors: Division of Biology and Biological Engineering, ‡Division of Engineering and Applied Science, §Division of Physics, Mathematics, and Astronomy, and ∥Kavli Nanoscience Institute, California Institute of Technology , Pasadena, California 91125, United States.
authors: Athanassios G
authors: AG
authors: Siapas
mesh_terms: D000818:Animals; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping / Q000295:instrumentation; D055724:Electrophysiological Phenomena; D004594:Electrophysiology / Q000295:instrumentation*; D004867:Equipment Design; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000295:instrumentation; D008839:Microelectrodes; D015335:Molecular Probes / Q000737:chemistry* / Q000627:therapeutic use; D049329:Nanostructures / Q000737:chemistry*; D009474:Neurons / Q000502:physiology; D012825:Silicon / Q000737:chemistry
chemical_list: D015335:Molecular Probes; D012825:Silicon
keywords: 3-D scalable packaging; Nanofabricated neural probes; brain mapping; high-density microelectrodes