title: Association of UCP2 -866G>A Polymorphism With Nonalcoholic Fatty Liver Disease in Patients From North-West of Iran.
abstract: OBJECTIVE
  To investigate the association of uncoupling protein-2 (UCP2) -866G > A gene polymorphism (rs659366) with nonalcoholic fatty liver disease (NAFLD).
  
  
  METHODS
  We performed a case-control study with a cohort of 75 patients with NAFLD (of Iranian ethnicity) and 76 healthy individuals of Iranian ethnicity. The UCP2 -866G > A polymorphism (rs659366) was determined using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
  
  
  RESULTS
  Patients with AA and AG genotypes were 71% and 68%, respectively, more likely to have NAFLD, compared with individuals with the GG genotype (reference group). In subjects with a GG genotype, serum triglyceride (TG) concentration was significantly higher in patients with NAFLD (P = .04). Serum alanine aminotransferase (ALT) concentrations in all 3 genotypes and serum aspartate aminotransferase (AST) concentrations in AG and GG genotypes of UCP2 gene polymorphism were significantly higher in patients (P <.05).
  
  
  CONCLUSIONS
  Our results revealed a modest modifier effect of -866G>A UCP2 polymorphism in patients with NAFLD.
authors: Nutrition Research Center, Department of Community Nutrition, School of Nutrition.
authors: Fatemeh
authors: F
authors: Mohseni
authors: Drug Applied Research Center (DARC).
authors: Safar
authors: S
authors: Farajnia
authors: Nutrition Research Center, Department of Community Nutrition, School of Nutrition abbasalizad_m@yahoo.com.
authors: Mahdieh Abbasalizad
authors: MA
authors: Farhangi
authors: Drug Applied Research Center (DARC).
authors: Manouchehr
authors: M
authors: Khoshbaten
authors: Road Traffic Injury Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
authors: Mohammad-Asghari
authors: MA
authors: Jafarabadi
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007492:Iran; D008297:Male; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease / Q000453:epidemiology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D000071246:Uncoupling Protein 2 / Q000235:genetics*
chemical_list: C000604389:UCP2 protein, human; D000071246:Uncoupling Protein 2
keywords: anthropometric indices; biochemical parameters; nonalcoholic fatty liver disease (NAFLD); uncoupling protein 2 (UCP2) gene; –866G>A polymorphism