title: Allele and genotype frequencies of genes relevant to anti-epileptic drug therapy in Mexican-Mestizo healthy volunteers.
abstract: OBJECTIVE
  To determine allele and genotype frequencies of genes influencing anti-epileptic drug therapy in Mexican-Mestizo (MM) healthy volunteers, and to evaluate whether these are different from those reported for other populations.
  
  
  METHODS
  Thirty-nine variants of CYP3A5, EPHX1, NR1I2, HNF4A, UGT1A1, UGT2B7, ABCC2, RALBP1, SCN1A, SCN2A and GABRA1 were genotyped in 300 MM healthy volunteers.
  
  
  RESULTS
  All studied alleles were presented in MM, except for seven UGT1A1 variants (*6-8, 14, 15, 27 and 29). Allele and genotype frequencies showed interethnic variations when compared with European, Asian and African populations. Allele frequencies of greater than 30% were observed in ten genes.
  
  
  CONCLUSIONS
  The results presented regarding the frequencies and interethnic differences of these polymorphisms should be taken into account for future pharmacogenetic studies of anti-epileptic drugs in MM patients with epilepsy.
authors: Doctorate in Biological & Health Sciences, Metropolitan Autonomous University, Campus Xochimilco, Mexico City, Mexico.
authors: Ingrid
authors: I
authors: Fricke-Galindo
authors: Department of Biological Systems, Metropolitan Autonomous University, Campus Xochimilco, Mexico City, Mexico.
authors: Alberto
authors: A
authors: Ortega-Vázquez
authors: Department of Neurogenetics & Molecular Biology, National Institute of Neurology & Neurosurgery Manuel Velasco Suárez, Mexico City, Mexico.
authors: Nancy
authors: N
authors: Monroy-Jaramillo
authors: CICAB Clinical Research Centre, Extremadura University Hospital & Medical School, Servicio Extremeño de Salud, Badajoz, Spain.
authors: Pedro
authors: P
authors: Dorado
authors: Department of Pharmacy, Chemistry Faculty, National Autonomous University of Mexico, Mexico City, Mexico.|Department of Neuropharmacology, National Institute of Neurology & Neurosurgery Manuel Velasco Suárez, Mexico City, Mexico.
authors: Helgi
authors: H
authors: Jung-Cook
authors: CICAB Clinical Research Centre, Extremadura University Hospital & Medical School, Servicio Extremeño de Salud, Badajoz, Spain.
authors: Eva
authors: E
authors: Peñas-Lledó
authors: CICAB Clinical Research Centre, Extremadura University Hospital & Medical School, Servicio Extremeño de Salud, Badajoz, Spain.
authors: Adrián
authors: A
authors: LLerena
authors: Department of Biological Systems, Metropolitan Autonomous University, Campus Xochimilco, Mexico City, Mexico.
authors: Marisol
authors: M
authors: López-López
keywords:   ; Mexican-Mestizo; anti-epileptics; pharmacogenetics