title: Molecular and epidemiological population-based integrative analysis of human and animal Mycobacterium bovis infections in a low-prevalence setting.
abstract: Human Mycobacterium bovis infections are considered to be due to reactivations, when involve elderly people, or to recent transmissions, when exposure is occupational. We determined the cause of M. bovis infections by genotyping M. bovis isolates in a population-based study integrating human and animal databases. Among the 1,586 tuberculosis (TB) cases in Asturias, Northern Spain (1,080,000 inhabitants), 1,567 corresponded to M. tuberculosis and 19 to M. bovis. The number of human isolates sharing genotype with cattle isolates was higher than expected (47%) for a setting with low prevalence of bovine TB and efficient control programs in cattle. The risk of exposure to infected animals was probable/possible in most of these matched cases (77.7%). Recent transmission was the likely explanation of most M. bovis infections in elderly people. A potential human-to-human transmission was found. Our study illustrates a model of collaboration between human and animal health professionals to provide a precise snapshot of the transmission of M. bovis in the human-animal interface.
authors: Unidad de Referencia Regional de Micobacterias, Hospital Universitario Central de Asturias, Oviedo, Spain.
authors: Juan José
authors: JJ
authors: Palacios
authors: Servicio Microbiología Clínica y Enfermedades Infecciosas, Hospital General Universitario Gregorio Marañón, Madrid, Spain; Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain; CIBER Enfermedades respiratorias, CIBERES, Spain; CEI Campus Moncloa, UCM-UPM, Madrid, Spain; Centro de Vigilancia Sanitaria Veterinaria (VISAVET), Universidad Complutense de Madrid, Madrid, Spain.
authors: Yurena
authors: Y
authors: Navarro
authors: CEI Campus Moncloa, UCM-UPM, Madrid, Spain; Centro de Vigilancia Sanitaria Veterinaria (VISAVET), Universidad Complutense de Madrid, Madrid, Spain.
authors: Beatriz
authors: B
authors: Romero
authors: Unidad de Referencia Regional de Micobacterias, Hospital Universitario Central de Asturias, Oviedo, Spain.
authors: Ana
authors: A
authors: Penedo
authors: Unidad de Referencia Regional de Micobacterias, Hospital Universitario Central de Asturias, Oviedo, Spain.
authors: Ángela
authors: Á
authors: Menéndez González
authors: Servicio de Vigilancia y Alertas Epidemiológicas, Dirección General de Salud Pública, Consejería de Sanidad, Principado de Asturias, Spain.
authors: M Dolores
authors: MD
authors: Pérez Hernández
authors: Servicio de Vigilancia y Alertas Epidemiológicas, Dirección General de Salud Pública, Consejería de Sanidad, Principado de Asturias, Spain.
authors: Ana
authors: A
authors: Fernández-Verdugo
authors: Lab. Sanidad Animal Jove, Oviedo, Spain.
authors: Francisca
authors: F
authors: Copano
authors: Servicio de Microbiología, Hospital de Cabueñes, Gijón, Spain.
authors: Aurora
authors: A
authors: Torreblanca
authors: Servicio Microbiología Clínica y Enfermedades Infecciosas, Hospital General Universitario Gregorio Marañón, Madrid, Spain; Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain; CIBER Enfermedades respiratorias, CIBERES, Spain; Departamento de Medicina, Facultad de Medicina, Universidad Complutense de Madrid, Madrid, Spain.
authors: Emilio
authors: E
authors: Bouza
authors: CEI Campus Moncloa, UCM-UPM, Madrid, Spain; Centro de Vigilancia Sanitaria Veterinaria (VISAVET), Universidad Complutense de Madrid, Madrid, Spain; Departamento de Sanidad Animal, Facultad de Veterinaria, Universidad Complutense de Madrid, Madrid, Spain.
authors: Lucas
authors: L
authors: Domínguez
authors: CEI Campus Moncloa, UCM-UPM, Madrid, Spain; Centro de Vigilancia Sanitaria Veterinaria (VISAVET), Universidad Complutense de Madrid, Madrid, Spain; Departamento de Sanidad Animal, Facultad de Veterinaria, Universidad Complutense de Madrid, Madrid, Spain.
authors: Lucía
authors: L
authors: de Juan
authors: Servicio Microbiología Clínica y Enfermedades Infecciosas, Hospital General Universitario Gregorio Marañón, Madrid, Spain; Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain; CIBER Enfermedades respiratorias, CIBERES, Spain; CEI Campus Moncloa, UCM-UPM, Madrid, Spain. Electronic address: dgviedma2@gmail.com.
authors: Darío
authors: D
authors: García-de-Viedma
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D002417:Cattle; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D009163:Mycobacterium bovis / Q000302:isolation & purification*; D009169:Mycobacterium tuberculosis / Q000302:isolation & purification*; D015995:Prevalence; D013030:Spain / Q000453:epidemiology; D014376:Tuberculosis / Q000453:epidemiology / Q000382:microbiology* / Q000635:transmission; D014380:Tuberculosis, Bovine / Q000382:microbiology* / Q000635:transmission; D055815:Young Adult
keywords: Genotyping; Human-animal; Molecular epidemiology; One health; Tuberculosis