title: Comparison of Pattern Electroretinography and Optical Coherence Tomography Parameters in Patients with Primary Open-Angle Glaucoma and Ocular Hypertension.
abstract: OBJECTIVE
  To investigate the correlation of visual field (VF), pattern electroretinography (PERG) and Fourier domain optical coherence tomography (FD-OCT) results in patients with ocular hypertension (OHT) and early primary open-angle glaucoma (POAG).
  
  
  METHODS
  The study included 72 eyes of 37 patients with early POAG, 76 eyes of 38 patients with OHT, and 60 eyes of 30 controls. All subjects underwent full ophthalmologic examination, VF assessment with 24-2 Humphrey standard automated perimetry (Swedish Interactive Thresholding Algorithm (SITA)-Standard), retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) thickness measurement with FD-OCT, and PERG P50 and N95 wave latency and amplitude measurements with electroretinography (Nihon Kohden).
  
  
  RESULTS
  With the exception of the nasal quadrant, all GCC parameters and RNFL results were significantly lower in the POAG group compared to the OHT and control groups. There was no statistically significant difference between the OHT and control group. PERG amplitudes were lower in the POAG and OHT groups than in the control group. Reduction in N95 amplitude was greater than that of P50 amplitude. No difference was detected in PERG latencies among groups. GCC was significantly correlated with VF and RNFL in the POAG group.
  
  
  CONCLUSIONS
  Significant thinning of the GCC and RNFL occurs in addition to VF pathologies in patients with early POAG, and these examinations should be concomitantly evaluated. During diagnostic assessment of patients with early POAG, GCC and RNFL analysis by FD-OCT are highly effective. GCC is as reliable as RNLF in the early diagnosis of glaucoma and there is a highly significant correlation between them. Dysfunction of ganglion cells in patients with OHT may be detected earlier using PERG amplitude analysis.
authors: Şişli Etfal Training and Research Hospital, Clinic of Ophthalmology, İstanbul, Turkey.
authors: Semra
authors: S
authors: Tiryaki Demir
authors: Kafkas University Faculty of Medicine, Department of Ophthalmology, Kars, Turkey.
authors: Mehmet Ersin
authors: ME
authors: Oba
authors: İstanbul University İstanbul Faculty of Medicine, Department of Physiology, İstanbul, Turkey.
authors: Ezgi Tuna
authors: ET
authors: Erdoğan
authors: Medipol University Faculty of Medicine, Department of Ophthalmology, İstanbul, Turkey.
authors: Mahmut
authors: M
authors: Odabaşı
authors: Şişli Etfal Training and Research Hospital, Clinic of Ophthalmology, İstanbul, Turkey.
authors: Ayşe Burcu
authors: AB
authors: Dirim
authors: Şişli Etfal Training and Research Hospital, Clinic of Ophthalmology, İstanbul, Turkey.
authors: Mehmet
authors: M
authors: Demir
authors: Şişli Etfal Training and Research Hospital, Clinic of Ophthalmology, İstanbul, Turkey.
authors: Efe
authors: E
authors: Can
authors: Şişli Etfal Training and Research Hospital, Clinic of Ophthalmology, İstanbul, Turkey.
authors: Orhan
authors: O
authors: Kara
authors: Şişli Etfal Training and Research Hospital, Clinic of Ophthalmology, İstanbul, Turkey.
authors: Selam
authors: S
authors: Yekta Şendül
keywords: Retinal nerve fiber layer; ganglion cell complex; ocular hypertension; pattern electroretinogram; primary open-angle glaucoma