title: Computational modelling for congenital heart disease: how far are we from clinical translation?
abstract: Computational models of congenital heart disease (CHD) have become increasingly sophisticated over the last 20 years. They can provide an insight into complex flow phenomena, allow for testing devices into patient-specific anatomies (pre-CHD or post-CHD repair) and generate predictive data. This has been applied to different CHD scenarios, including patients with single ventricle, tetralogy of Fallot, aortic coarctation and transposition of the great arteries. Patient-specific simulations have been shown to be informative for preprocedural planning in complex cases, allowing for virtual stent deployment. Novel techniques such as statistical shape modelling can further aid in the morphological assessment of CHD, risk stratification of patients and possible identification of new 'shape biomarkers'. Cardiovascular statistical shape models can provide valuable insights into phenomena such as ventricular growth in tetralogy of Fallot, or morphological aortic arch differences in repaired coarctation. In a constant move towards more realistic simulations, models can also account for multiscale phenomena (eg, thrombus formation) and importantly include measures of uncertainty (ie, CIs around simulation results). While their potential to aid understanding of CHD, surgical/procedural decision-making and personalisation of treatments is undeniable, important elements are still lacking prior to clinical translation of computational models in the field of CHD, that is, large validation studies, cost-effectiveness evaluation and establishing possible improvements in patient outcomes.
authors: Bristol Heart Institute, School of Clinical Sciences, University of Bristol, Bristol, UK.|Cardiorespiratory Unit, Great Ormond Street Hospital for Children, NHS Foundation Trust, London, UK.
authors: Giovanni
authors: G
authors: Biglino
authors: Cardiorespiratory Unit, Great Ormond Street Hospital for Children, NHS Foundation Trust, London, UK.|Institute of Cardiovascular Science, University College London, London, UK.
authors: Claudio
authors: C
authors: Capelli
authors: Cardiorespiratory Unit, Great Ormond Street Hospital for Children, NHS Foundation Trust, London, UK.|Institute of Cardiovascular Science, University College London, London, UK.
authors: Jan
authors: J
authors: Bruse
authors: Cardiorespiratory Unit, Great Ormond Street Hospital for Children, NHS Foundation Trust, London, UK.|Institute of Cardiovascular Science, University College London, London, UK.
authors: Giorgia M
authors: GM
authors: Bosi
authors: Cardiorespiratory Unit, Great Ormond Street Hospital for Children, NHS Foundation Trust, London, UK.|Institute of Cardiovascular Science, University College London, London, UK.
authors: Andrew M
authors: AM
authors: Taylor
authors: Cardiorespiratory Unit, Great Ormond Street Hospital for Children, NHS Foundation Trust, London, UK.|Institute of Cardiovascular Science, University College London, London, UK.
authors: Silvia
authors: S
authors: Schievano
mesh_terms: D057005:Bioengineering / Q000379:methods; D003198:Computer Simulation; D006330:Heart Defects, Congenital / Q000473:pathology / Q000503:physiopathology* / Q000601:surgery*; D006801:Humans; D008955:Models, Cardiovascular; D066230:Patient-Specific Modeling; D019736:Prostheses and Implants; D057170:Translational Research, Biomedical / Q000379:methods