title: Erythema Nodosum-Like Panniculitis as a False-Positive 18F-FDG PET/CT in Advanced Melanoma Treated With Dabrafenib and Trametinib.
abstract: We present a 35-year-old woman with left axillary mass. Histopathological analysis revealed metastatic infiltration for BRAF-mutant melanoma. F-FDG PET/CT showed bilateral axillary lymphadenopathy as well as bone and subcutaneous metastases. Dabrafenib (a BRAF inhibitor) and trametinib (a MEK inhibitor) combined therapy was started with a complete metabolic response established by 2 consecutive PET/CT scans. A follow-up PET/CT showed FDG uptake in several subcutaneous nodules in both distal legs, suggesting metastases. Painless cutaneous lesions were observed on physical examination, and biopsy revealed erythema nodosum-like panniculitis.
authors: From the Departments of *Nuclear Medicine, and †Oncology, Marqués de Valdecilla University Hospital, Molecular Imaging Group (IDIVAL), University of Cantabria, Santander, Spain.
authors: Isabel
authors: I
authors: Martínez-Rodríguez
authors: Almudena
authors: A
authors: García-Castaño
authors: Remedios
authors: R
authors: Quirce
authors: Julio
authors: J
authors: Jiménez-Bonilla
authors: Ignacio
authors: I
authors: Banzo
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D004893:Erythema Nodosum / Q000000981:diagnostic imaging* / Q000209:etiology; D005189:False Positive Reactions; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007093:Imidazoles / Q000009:adverse effects* / Q000627:therapeutic use; D008545:Melanoma / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D010091:Oximes / Q000009:adverse effects* / Q000627:therapeutic use; D015434:Panniculitis / Q000000981:diagnostic imaging* / Q000209:etiology; D000072078:Positron Emission Tomography Computed Tomography; D011728:Pyridones / Q000009:adverse effects* / Q000627:therapeutic use; D011744:Pyrimidinones / Q000009:adverse effects* / Q000627:therapeutic use; D019275:Radiopharmaceuticals
chemical_list: D000970:Antineoplastic Agents; D007093:Imidazoles; D010091:Oximes; D011728:Pyridones; D011744:Pyrimidinones; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; C560077:trametinib; C561627:dabrafenib