title: Fat body remodeling and homeostasis control in Drosophila.
abstract: Remarkable advances have been made in recent years in our understanding of the Drosophila fat body and its functions in energy storage, immune response and nutrient sensing. The fat body interplays with other tissues to respond to the physiological needs of the body's growth and coordinates various metabolic processes at different developmental stages and under different environmental conditions. The identification of various conserved genetic functions and signaling pathways relating to the Drosophila fat body may provide clues to lipometabolic disease and other aspects of tissue remodeling in humans. Here, we discuss recent insights into how regulation of fat body remodeling contributes to hemostasis with a special focus on how signaling networks and internal physiological states shape different aspects of the lipid metabolism in Drosophila.
authors: Division of Human Reproduction and Developmental Genetics, the Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China; Institute of Genetics, Zhejiang University and Department of Genetics, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China; College of Life Sciences, Zhejiang University, Hangzhou, China.
authors: Huimei
authors: H
authors: Zheng
authors: Division of Human Reproduction and Developmental Genetics, the Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China; Institute of Genetics, Zhejiang University and Department of Genetics, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China; Joint Institute of Genetics and Genomic Medicine between Zhejiang University and University of Toronto, Zhejiang University, Hangzhou, Zhejiang, China.
authors: Xiaohang
authors: X
authors: Yang
authors: Division of Human Reproduction and Developmental Genetics, the Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China; Institute of Genetics, Zhejiang University and Department of Genetics, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China. Electronic address: xyyongm@zju.edu.cnc.
authors: Yongmei
authors: Y
authors: Xi
mesh_terms: D000818:Animals; D004330:Drosophila / Q000033:anatomy & histology / Q000502:physiology*; D004734:Energy Metabolism; D005216:Fat Body / Q000033:anatomy & histology / Q000502:physiology*; D006706:Homeostasis; D050356:Lipid Metabolism; D008136:Longevity; D015398:Signal Transduction
keywords: Drosophila; Energy storage; Fat body remodeling; Fat mobilization; Lipometabolism