title: A Clinical Trial about a Food Supplement Containing α-Lipoic Acid on Oxidative Stress Markers in Type 2 Diabetic Patients.
abstract: The aim of this study was to evaluate the effect of a food supplement containing α-lipoic acid and of a placebo on glyco-metabolic control and on oxidative stress markers in type 2 diabetics. We randomized 105 diabetics to either a supplementation containing 600 mg of α-lipoic acid, 165 mg ofL-carnosin, 7.5 mg of zinc, and vitamins of group B, or a placebo, for three months. We evaluated body mass index, fasting plasma glucose (FPG), post-prandial-glucose (PPG), glycated hemoglobin (HbA1c), fasting plasma insulin (FPI), HOMA-index (HOMA-IR), lipid profile, high sensitivity C-reactive protein (Hs-CRP), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), malondialdehyde (MDA). There was a reduction of FPG, PPG, and HbA1cwith the food supplement containing α-lipoic acid compared with a baseline, and with the placebo. Concerning lipid profile, we observed a reduction of LDL-C, and Tg with the food supplement, compared with both the baseline, and the placebo. There was a reduction of Hs-CRP with the food supplement containing α-lipoic acid, both compared with the baseline and the placebo. An increase of SOD, and GSH-Px, and a decrease of MDA were reached by the food supplement containing α-lipoic acid, both compared with the baseline and the placebo. We can conclude that the food supplement containing α-lipoic acid,L-carnosin, zinc, and vitamins of group B improved glycemic control, lipid profile, and anti-oxidative stress markers.
authors: Centre of Diabetes and Metabolic Diseases, Department of Internal Medicine and Therapeutics, University of Pavia and Fondazione IRCCS Policlinico S. Matteo, 2-27100 Pavia, Italy. giuseppe.derosa@unipv.it.|Center for Prevention, Surveillance, Diagnosis and Treatment of Rare Diseases, Fondazione IRCCS Policlinico S. Matteo, 2-27100 Pavia, Italy. giuseppe.derosa@unipv.it.|Center for the Study of Endocrine-Metabolic Pathophysiology and Clinical Research, University of Pavia, 2-27100 Pavia, Italy. giuseppe.derosa@unipv.it.|Laboratory of Molecular Medicine, University of Pavia, 2-27100 Pavia, Italy. giuseppe.derosa@unipv.it.
authors: Giuseppe
authors: G
authors: Derosa
authors: Centre of Diabetes and Metabolic Diseases, Department of Internal Medicine and Therapeutics, University of Pavia and Fondazione IRCCS Policlinico S. Matteo, 2-27100 Pavia, Italy. labmedmol@smatteo.pv.it.|Center for Prevention, Surveillance, Diagnosis and Treatment of Rare Diseases, Fondazione IRCCS Policlinico S. Matteo, 2-27100 Pavia, Italy. labmedmol@smatteo.pv.it.|Laboratory of Molecular Medicine, University of Pavia, 2-27100 Pavia, Italy. labmedmol@smatteo.pv.it.
authors: Angela
authors: A
authors: D'Angelo
authors: Centre of Diabetes and Metabolic Diseases, Department of Internal Medicine and Therapeutics, University of Pavia and Fondazione IRCCS Policlinico S. Matteo, 2-27100 Pavia, Italy. dr.davideromano85@gmail.com.
authors: Davide
authors: D
authors: Romano
authors: Centre of Diabetes and Metabolic Diseases, Department of Internal Medicine and Therapeutics, University of Pavia and Fondazione IRCCS Policlinico S. Matteo, 2-27100 Pavia, Italy. pamelamaffioli@hotmail.it.|Center for the Study of Endocrine-Metabolic Pathophysiology and Clinical Research, University of Pavia, 2-27100 Pavia, Italy. pamelamaffioli@hotmail.it.|PhD School in Experimental Medicine, University of Pavia, 2-27100 Pavia, Italy. pamelamaffioli@hotmail.it.
authors: Pamela
authors: P
authors: Maffioli
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose; D015992:Body Mass Index; D001835:Body Weight; D002097:C-Reactive Protein / Q000378:metabolism; D002336:Carnosine / Q000008:administration & dosage; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000178:diet therapy / Q000473:pathology; D019587:Dietary Supplements; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000178:diet therapy* / Q000473:pathology; D007333:Insulin Resistance / Q000235:genetics; D050356:Lipid Metabolism / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000187:drug effects*; D008063:Thioctic Acid / Q000008:administration & dosage; D015032:Zinc / Q000008:administration & dosage
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D002097:C-Reactive Protein; D002336:Carnosine; D005979:Glutathione Peroxidase; D006442:Glycated Hemoglobin; D008063:Thioctic Acid; D015032:Zinc; C517652:hemoglobin A1c protein, human
keywords: L-carnosin; malondialdehyde; oxidative stress; α-lipoic acid