title: Sending Out an SOS: Mitochondria as a Signaling Hub.
abstract: Normal cellular physiology is critically dependent on numerous mitochondrial activities including energy conversion, cofactor and precursor metabolite synthesis, and regulation of ion and redox homeostasis. Advances in mitochondrial research during the last two decades provide solid evidence that these organelles are deeply integrated with the rest of the cell and multiple mechanisms are in place to monitor and communicate functional states of mitochondria. In many cases, however, the exact molecular nature of various mitochondria-to-cell communication pathways is only beginning to emerge. Here, we review various signals emitted by distressed or dysfunctional mitochondria and the stress-responsive pathways activated in response to these signals in order to restore mitochondrial function and promote cellular survival.
authors: Department of Biochemistry, University of Nebraska-Lincoln Lincoln, NE, USA.
authors: Iryna
authors: I
authors: Bohovych
authors: Department of Biochemistry, University of Nebraska-LincolnLincoln, NE, USA; Nebraska Redox Biology Center, University of Nebraska-LincolnLincoln, NE, USA; Fred and Pamela Buffett Cancer Center, University of Nebraska Medical CenterOmaha, NE, USA.
authors: Oleh
authors: O
authors: Khalimonchuk
keywords: metabolites; mitochondria; mitochondrial stress; reactive oxygen species; retrograde signaling