title: Chiral Phosphoric Acid-Catalyzed Enantioselective Reductive Amination of 2-Pyridyl Ketones: Construction of Structurally Chiral Pyridine-Based Ligands.
abstract: A chiral phosphoric acid-catalyzed one-pot enantioselective reductive amination of 2-pyridyl ketones was realized to provide chiral pyridine-based ligands in excellent yields with high enantioselectivities (up to 98% yield, 94% ee). Computational studies on the key intermediate imine and transition state of the hydride transfer process revealed that the nitrogen atom of the pyridyl ring might be an important factor to significantly promote both the reaction activity and enantioselectivity.
authors: Department of Chemistry, Xinjiang Normal University , Urumqi 830054, China.
authors: Abulikemu
authors: A
authors: Abudu Rexit
authors: Department of Chemistry, University of Science and Technology of China , Hefei 230026, China.
authors: Shiwei
authors: S
authors: Luo
authors: School of Chemistry and Chemical Engineering, Xinjiang University , Urumqi 830046, China.
authors: Maihemuti
authors: M
authors: Mailikezati