title: Example of the drug interaction between ciclosporin and orlistat, resulting in relapse of Evan's syndrome.
abstract: A man aged 35 years with a history of Evan's syndrome presented to the clinic with jaundice and shortness of breath, with further testing indicating a relapse of his previously well-controlled condition, for which he was taking ciclosporin. This followed shortly after he had started taking orlistat to prevent weight gain from a course of steroids, and once the orlistat was stopped, his platelets began to rise. The patient required 4 months of steroid treatment before his platelet levels finally stabilised and he could be put back on his regular medicine regime.
authors: Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK.
authors: Irina
authors: http://orcid.org/0000-0002-9546-6641
authors: I
authors: Earnshaw
authors: Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK.
authors: Jecko
authors: J
authors: Thachil
mesh_terms: D000328:Adult; D000744:Anemia, Hemolytic, Autoimmune / Q000139:chemically induced* / Q000188:drug therapy; D019440:Anti-Obesity Agents / Q000009:adverse effects*; D016572:Cyclosporine / Q000009:adverse effects*; D004347:Drug Interactions; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D007783:Lactones / Q000009:adverse effects*; D008297:Male; D000077403:Orlistat; D012008:Recurrence; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000188:drug therapy
chemical_list: D019440:Anti-Obesity Agents; D007166:Immunosuppressive Agents; D007783:Lactones; D016572:Cyclosporine; D000077403:Orlistat