title: Plasma Phosphatidylcholines Fatty Acids in Men with Squamous Cell Esophageal Cancer: Chemoradiotherapy Improves Abnormal Profile.
abstract: BACKGROUND Abnormal metabolism of fatty acids (FA) is considered to play a role in human cancers, including esophageal cancer (EC). Nevertheless, there have been only a few studies dealing with the influence of the chemotherapy or radiotherapy on the plasma FA profiles. In this work we compared FA in plasma phosphatidylcholine (PC) of the patients with squamous EC and healthy subjects and investigated changes in the FA spectrum during neoadjuvant chemoradiotherapy (CRT). MATERIAL AND METHODS Forty-two men with squamous EC were compared with age-matched healthy controls. The EC group was subjected to concurrent neoadjuvant CRT. We analyzed FA in plasma PC before and after CRT. RESULTS The EC group was characterized by increased levels of both saturated and monounsaturated FA, associated with an increased index of SCD1 (stearoyl-CoA desaturase-1). Moreover, decreased levels of linoleic acid and total polyunsaturated FA (PUFA) n-6 were found in EC patients. The CRT was accompanied by increased docosahexaenoic acid and total PUFA n-3 content in plasma PC, concurrently with the decrease of estimated activity of SCD1. CONCLUSIONS We found that patients with EC had altered FA profile in plasma PC, which could be related to abnormal FA metabolism in cancer (e.g., altered synthesis de novo, b-oxidation, desaturation, and elongation). The described changes in FA profiles during CRT could be involved in favorable functioning of CRT. Further studies investigating the plasma FA compositions and their changes due to CRT in EC patients are warranted.
authors: Department of Oncology, 1st Faculty of Medicine of Charles University in Prague and General University Hospital, Prague, Czech Republic.
authors: Milada
authors: M
authors: Zemanova
authors: 4th Department of Internal Medicine, 1st Faculty of Medicine of Charles University in Prague and General University Hospital, Prague, Czech Republic.
authors: Marek
authors: M
authors: Vecka
authors: Department of Oncology, 1st Faculty of Medicine of Charles University in Prague and General University Hospital, Prague, Czech Republic.
authors: Luboš
authors: L
authors: Petruželka
authors: 4th Department of Internal Medicine, 1st Faculty of Medicine of Charles University in Prague and General University Hospital, Prague, Czech Republic.
authors: Barbora
authors: B
authors: Staňková
authors: 4th Department of Internal Medicine, 1st Faculty of Medicine of Charles University in Prague and General University Hospital, Prague, Czech Republic.
authors: Aleš
authors: A
authors: Žák
authors: 4th Department of Internal Medicine, 1st Faculty of Medicine of Charles University in Prague and General University Hospital, Prague, Czech Republic.
authors: Miroslav
authors: M
authors: Zeman
mesh_terms: D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000097:blood* / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D016022:Case-Control Studies; D059248:Chemoradiotherapy; D004938:Esophageal Neoplasms / Q000097:blood* / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D000077277:Esophageal Squamous Cell Carcinoma; D005227:Fatty Acids / Q000097:blood*; D005229:Fatty Acids, Monounsaturated / Q000097:blood; D006801:Humans; D050356:Lipid Metabolism / Q000502:physiology; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D010713:Phosphatidylcholines / Q000097:blood*; D013230:Stearoyl-CoA Desaturase / Q000378:metabolism; D016896:Treatment Outcome
chemical_list: D005227:Fatty Acids; D005229:Fatty Acids, Monounsaturated; D010713:Phosphatidylcholines; D013230:Stearoyl-CoA Desaturase