title: Folic acid conjugates with photosensitizers for cancer targeting in photodynamic therapy: Synthesis and photophysical properties.
abstract: Recent researches in photodynamic therapy have focused on novel techniques to enhance tumour targeting of anticancer drugs and photosensitizers. Coupling a photosensitizer with folic acid could allow more effective targeting of folate receptors which are over-expressed on the surface of many tumour cells. In this study, different folic acid-OEG-conjugated photosensitizers were synthesized, characterized and their photophysical properties were evaluated. The introduction of an OEG does not significantly improve the hydrophilicity of the FA-porphyrin. All the FA-targeted photosensitizers present good to very good photophysical properties. The best one appears to be Ce6. Molar extinction coefficient, fluorescence and singlet oxygen quantum yields were determined and were compared to the corresponding photosensitizer alone.
authors: Laboratoire Réactions et Génie des Procédés, UMR-CNRS 7274, Lorraine-Université, 1 rue Grandville, BP 20451, 54001 Nancy Cedex, France.
authors: Aurélie
authors: A
authors: Stallivieri
authors: Laboratoire Réactions et Génie des Procédés, UMR-CNRS 7274, Lorraine-Université, 1 rue Grandville, BP 20451, 54001 Nancy Cedex, France.
authors: Ludovic
authors: L
authors: Colombeau
authors: Laboratoire Réactions et Génie des Procédés, UMR-CNRS 7274, Lorraine-Université, 1 rue Grandville, BP 20451, 54001 Nancy Cedex, France.
authors: Gulim
authors: G
authors: Jetpisbayeva
authors: Laboratoire Réactions et Génie des Procédés, UMR-CNRS 7274, Lorraine-Université, 1 rue Grandville, BP 20451, 54001 Nancy Cedex, France.
authors: Albert
authors: A
authors: Moussaron
authors: Laboratoire Réactions et Génie des Procédés, UMR-CNRS 7274, Lorraine-Université, 1 rue Grandville, BP 20451, 54001 Nancy Cedex, France.
authors: Bauyrzhan
authors: B
authors: Myrzakhmetov
authors: Laboratoire Réactions et Génie des Procédés, UMR-CNRS 7274, Lorraine-Université, 1 rue Grandville, BP 20451, 54001 Nancy Cedex, France.
authors: Philippe
authors: P
authors: Arnoux
authors: Laboratoire de Chimie Physique macromoléculaire, UMR-CNRS 7375, Lorraine-Université, 1 rue Grandville, BP 20451, 54001 Nancy Cedex, France.
authors: Samir
authors: S
authors: Acherar
authors: Laboratoire de Chimie Physique macromoléculaire, UMR-CNRS 7375, Lorraine-Université, 1 rue Grandville, BP 20451, 54001 Nancy Cedex, France.
authors: Régis
authors: R
authors: Vanderesse
authors: Laboratoire Réactions et Génie des Procédés, UMR-CNRS 7274, Lorraine-Université, 1 rue Grandville, BP 20451, 54001 Nancy Cedex, France. Electronic address: celine.frochot@univ-lorraine.fr.
authors: Céline
authors: C
authors: Frochot
mesh_terms: D060326:Chemistry Techniques, Synthetic; D002735:Chlorophyllides; D004048:Diethylamines / Q000138:chemical synthesis / Q000737:chemistry*; D005492:Folic Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000138:chemical synthesis / Q000737:chemistry*; D011166:Porphyrins / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D002735:Chlorophyllides; D004048:Diethylamines; D017319:Photosensitizing Agents; D011166:Porphyrins; C062985:phytochlorin; D005492:Folic Acid; C492592:2,2'-(ethylenedioxy)diethylamine
keywords: Cancer targeting; Folic acid; Photodynamic therapy; Photosensitizers; Singlet oxygen