title: "Magic Bullet": Eccentric Macular Hole as a Complication from Dexamethasone Implant Insertion.
abstract: Introduction. Intravitreal drug injections and implants are generally safe but do carry some risk, from both the procedure itself and adverse effects of the medications. We report a case of an eccentric macular hole after dexamethasone implant (Ozurdex®) administration.Ex vitroforce testing was performed to evaluate dexamethasone implant injection force.Methods. Five dexamethasone implant (Ozurdex) applicators were placed 16 mm from a force plate and the force of the injected dexamethasone pellet was recorded in Newtons. Four dexamethasone implant applicators were placed 16 mm from a force plate in a basic saline solution and the force of the pellet was recorded.Results. Average maximum force in air was 0.77 N and 0.024 N in a basic saline solution (BSS).Conclusion. We present a case report of an eccentric macular hole after dexamethasone implant administration. We hypothesize a mechanical injury to the retina during insertion caused the macular hole. Force testing done in air demonstrated sufficient force from the pellet injection to cause retinal damage though injections done in BSS showed reduced forces.
authors: Department of Ophthalmology, University of Colorado, 1674 Aurora Ct., Aurora, CO 80045, USA.
authors: Logan
authors: 0000-0001-5736-8437
authors: L
authors: Christensen
authors: Department of Ophthalmology, University of Colorado, 1674 Aurora Ct., Aurora, CO 80045, USA.
authors: Riley
authors: R
authors: Sanders
authors: Department of Ophthalmology, University of Colorado, 1674 Aurora Ct., Aurora, CO 80045, USA.
authors: Jeffrey
authors: J
authors: Olson