title: Hypoxic regulation of neutrophil function and consequences for Staphylococcus aureus infection.
abstract: Staphylococcal infection and neutrophilic inflammation can act in concert to establish a profoundly hypoxic environment. In this review we summarise how neutrophils and Staphylococcus aureus are adapted to function under hypoxic conditions, with a particular focus on the impaired ability of hypoxic neutrophils to effect Staphylococcus aureus killing.
authors: Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge University Hospitals, Hills Road, Cambridge, CB2 0QQ, UK.
authors: Katharine M
authors: KM
authors: Lodge
authors: Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield Medical School, Beech Hill Road, Sheffield, S10 2RX, UK.
authors: A A Roger
authors: AA
authors: Thompson
authors: Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge University Hospitals, Hills Road, Cambridge, CB2 0QQ, UK. Electronic address: erc24@cam.ac.uk.
authors: Edwin R
authors: ER
authors: Chilvers
authors: Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield Medical School, Beech Hill Road, Sheffield, S10 2RX, UK.
authors: Alison M
authors: AM
authors: Condliffe
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D000860:Hypoxia / Q000473:pathology*; D007113:Immunity, Innate; D009504:Neutrophils / Q000276:immunology*; D013203:Staphylococcal Infections / Q000276:immunology* / Q000473:pathology*; D013211:Staphylococcus aureus / Q000276:immunology* / Q000472:pathogenicity*
keywords: Hypoxia; Neutrophil; Staphylococcus aureus