title: Palladium(II) Catalyzed C-H Functionalization Cascades for the Diastereoselective Synthesis of Polyheterocycles.
abstract: C-H activation offers huge potential in the generation of complex structures from simple starting materials. Herein we report the development of a highly diastereoselective palladium(II) catalyzed C-H functionalization cascade to produce novel, unsaturated polyheterocycles from simple diene-tethered heterocyclic starting materials. The reaction is applicable to both indole and pyrrole based substrates and tolerates a wide range of functional group substitutions around the heteroaromatic core. The polyheterocyclic products are formed as single diastereoisomers, with two new stereocenters formed in a single step.
authors: School of Chemistry, University of Bristol , Cantocks Close, Bristol BS8 1TS, U.K.
authors: Michael S
authors: MS
authors: Watt
authors: School of Chemistry, University of Bristol , Cantocks Close, Bristol BS8 1TS, U.K.
authors: Kevin I
authors: KI
authors: Booker-Milburn