title: Electrophysiological Features of Telocytes.
abstract: Telocytes (TCs) are interstitial cells described in multiple structures, including the gastrointestinal tract, respiratory tract, urinary tract, uterus, and heart. Several studies have indicated the possibility that TCs are involved in the pacemaker potential in these organs. It is supposed that TCs are interacting with the neighboring muscular cells and their network contributes to the initiation and propagation of the electrical potentials. In order to understand the contribution of TCs to various excitability mechanisms, it is necessary to analyze the plasma membrane proteins (e.g., ion channels) functionally expressed in these cells. So far, potassium, calcium, and chloride currents, but not sodium currents, have been described in TCs in primary cell culture from different tissues. Moreover, TCs have been described as sensors for mechanical stimuli (e.g., contraction, extension, etc.). In conclusion, TCs might play an essential role in gastrointestinal peristalsis, in respiration, in pregnant uterus contraction, or in miction, but further highlighting studies are necessary to understand the molecular mechanisms and the cell-cell interactions by which TCs contribute to the tissue excitability and pacemaker potentials initiation/propagation.
authors: Department of Anatomy, Animal Physiology and Biophysics, Faculty of Biology, University of Bucharest, Splaiul Independentei 91-95, Bucharest, 050095, Romania.
authors: Daniel Dumitru
authors: DD
authors: Banciu
authors: Department of Anatomy, Animal Physiology and Biophysics, Faculty of Biology, University of Bucharest, Splaiul Independentei 91-95, Bucharest, 050095, Romania.
authors: Adela
authors: A
authors: Banciu
authors: Department of Anatomy, Animal Physiology and Biophysics, Faculty of Biology, University of Bucharest, Splaiul Independentei 91-95, Bucharest, 050095, Romania. beatricemihaela.radu@univr.it.|Department of Neurological and Movement Sciences, University of Verona, Strada Le Grazie 8, Verona, 37134, Italy. beatricemihaela.radu@univr.it.
authors: Beatrice Mihaela
authors: BM
authors: Radu
mesh_terms: D000818:Animals; D001683:Biological Clocks / Q000502:physiology*; D020746:Calcium Channels, L-Type / Q000235:genetics / Q000378:metabolism; D018118:Chloride Channels / Q000235:genetics / Q000378:metabolism; D003238:Connective Tissue / Q000502:physiology; D005786:Gene Expression Regulation; D006168:Guinea Pigs; D006801:Humans; D015640:Ion Channel Gating / Q000502:physiology*; D051656:KCNQ Potassium Channels / Q000235:genetics / Q000378:metabolism; D008564:Membrane Potentials / Q000502:physiology*; D051379:Mice; D018408:Patch-Clamp Techniques; D020033:Protein Isoforms / Q000235:genetics / Q000378:metabolism; D051381:Rats; D000067170:Telocytes / Q000166:cytology / Q000502:physiology*; D061566:Voltage-Gated Sodium Channels / Q000235:genetics / Q000378:metabolism
chemical_list: D020746:Calcium Channels, L-Type; D018118:Chloride Channels; D051656:KCNQ Potassium Channels; C412231:KCNQ5 protein, human; D020033:Protein Isoforms; D061566:Voltage-Gated Sodium Channels
keywords: Calcium currents; Chloride currents; In vitro electrophysiology; Interstitial cells of Cajal; Pacemaker potential; Patch clamp; Potassium currents; Telocytes