title: A Repetitive Concussive Head Injury Model in Mice.
abstract: Despite the concussion/ mild traumatic brain injury (mTBI) being the most frequent occurrence of traumatic brain injury, there is still a lack of knowledge on the injury and its effects. To develop a better understanding of concussions, animals are often used because they provide a controlled, rigorous, and efficient model. Studies have adapted traditional animal models to perform mTBI to stimulate mild injury severity by changing the injury parameters. These models have been used because they can produce morphologically similar brain injuries to the clinical condition and provide a spectrum of injury severities. However, they are limited in their ability to present the identical features of injuries in patients. Using a traditional impact system, a repetitive concussive injury (rCHI) model can induce mild to moderate human-like concussion. The injury degree can be determined by measuring the period of loss of consciousness (LOC) with a sign of a transient termination of breathing. The rCHI model is beneficial to use for its accuracy and simplicity in determining mTBI effects and potential treatments.
authors: Program for Neurotrauma, Neuroproteomics & Biomarkers Research, University of Florida; Department of Psychiatry, University of Florida; zhihuiyang@ufl.edu.
authors: Zhihui
authors: Z
authors: Yang
authors: Program for Neurotrauma, Neuroproteomics & Biomarkers Research, University of Florida; Department of Psychiatry, University of Florida.
authors: Fan
authors: F
authors: Lin
authors: Program for Neurotrauma, Neuroproteomics & Biomarkers Research, University of Florida; Department of Psychiatry, University of Florida.
authors: Amanda S
authors: AS
authors: Weissman
authors: Program for Neurotrauma, Neuroproteomics & Biomarkers Research, University of Florida; Department of Psychiatry, University of Florida.
authors: Emily
authors: E
authors: Jaalouk
authors: Department of Neuroscience, University of Florida.
authors: Qing-Shan
authors: QS
authors: Xue
authors: Program for Neurotrauma, Neuroproteomics & Biomarkers Research, University of Florida; Department of Psychiatry, University of Florida.
authors: Kevin K W
authors: KK
authors: Wang
mesh_terms: D000818:Animals; D001924:Brain Concussion; D001930:Brain Injuries; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice