title: Obesity is associated with better survival and functional outcome after acute intracerebral hemorrhage.
abstract: OBJECTIVE
  To evaluate the association of obesity measured by body mass index (BMI) with mortality and functional outcome in patients with acute intracerebral hemorrhage (ICH).
  
  
  METHODS
  Data were from 1571 patients with ICH enrolled in a national, multi-centre, prospective, hospital-based register: the ChinaQUEST (Quality Evaluation of Stroke Care and Treatment) study. The outcomes included all-cause mortality at 12months, and death or high dependency at 3 and 12months. High dependency was defined as a modified Rankin Scale score of 3-5.
  
  
  RESULTS
  Of 1571 patients with ICH, 109 were underweight (BMI<18.5kg/m2), 657 were normal-weight (BMI 18.5-23kg/m2), 341 were overweight (BMI 23-25kg/m2) and 464 were obese (BMI≥25kg/m2). Compared with normal-weight patients, obese patients had significantly decreased risks of death at 12months (HR: 0.71, 95% CI: 0.56-0.91) and death or high dependency at 3 and 12months (OR: 0.71, 95% CI: 0.53-0.95; OR: 0.69, 95% CI: 0.51-0.94) after adjusting for baseline characteristics. Neither underweight nor overweight was associated with these three outcomes significantly.
  
  
  CONCLUSIONS
  In patients with acute ICH, being obese is associated with a decreased mortality and better functional recovery. Further interventional studies are needed to guide the weight management strategy for patients with ICH.
authors: Department of Neurology, Peking University First Hospital, Beijing, China.
authors: Weiping
authors: W
authors: Sun
authors: Department of Neurology, Duke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA.
authors: Ying
authors: Y
authors: Xian
authors: Department of Neurology, Peking University First Hospital, Beijing, China. Electronic address: ynhuang@sina.com.
authors: Yining
authors: Y
authors: Huang
authors: Department of Neurology, Peking University First Hospital, Beijing, China.
authors: Wei
authors: W
authors: Sun
authors: Department of Neurology, Peking University First Hospital, Beijing, China.
authors: Ran
authors: R
authors: Liu
authors: Department of Neurology, Peking University First Hospital, Beijing, China.
authors: Fan
authors: F
authors: Li
authors: The George Institute for Global Health, Royal Prince Alfred Hospital and the University of Sydney, Sydney, Australia.
authors: Jade W
authors: JW
authors: Wei
authors: The Center for Epidemiological Studies and Clinical Trials, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
authors: Ji-Guang
authors: JG
authors: Wang
authors: Department of Neurology, West China Hospital, Sichuan University, Chengdu, China.
authors: Ming
authors: M
authors: Liu
authors: Peking University Clinical Research Institute, Peking University Health Science Center, Beijing, China.
authors: Yangfeng
authors: Y
authors: Wu
authors: Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong, China.
authors: Lawrence K S
authors: LKS
authors: Wong
authors: The George Institute for Global Health, Royal Prince Alfred Hospital and the University of Sydney, Sydney, Australia.
authors: Craig S
authors: CS
authors: Anderson
mesh_terms: D000368:Aged; D015992:Body Mass Index; D002543:Cerebral Hemorrhage / Q000150:complications* / Q000401:mortality* / Q000503:physiopathology; D002681:China; D004185:Disability Evaluation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications* / Q000401:mortality* / Q000503:physiopathology; D011446:Prospective Studies; D020127:Recovery of Function; D012042:Registries; D012680:Sensitivity and Specificity
keywords: Dependency; Intracerebral hemorrhage; Mortality; Obesity; Outcome