title: Fasting and post-prandial peptide YY levels in obese patients before and after mini versus Roux-en-Y gastric bypass.
abstract: BACKGROUNDː The mechanisms underlying the metabolic effect of surgical treatment for morbid obesity are still unclear. Furthermore, the hormonal and metabolic response to the promising and less-invasive version of Roux-en-Y gastric bypass (RYGB), i.e. mini gastric bypass (MGB), is poorly known. The aim of this study was to evaluate pre- and postprandial changes in peptide YY (PYY) and metabolic parameters in obese patients without diabetes and cardiovascular complications treated by both versions of gastric bypass. METHODSː Venous blood for PYY and other assays was collected three months before and six months after bariatric operation (MGB and RYGB), in the fasting state and two hours after the consumption of a standard 300-kcal mixed meal (Nutridrink Standard, Nutricia Advanced Medical Nutrition, part of the Danone company, Schiphol, The Netherlands). RESULTSː In the MGB group, elevated concentrations of the PYY has been detected both fasting and postprandially. The effect of the MGB on the PYY levels did not differ from the RYGB group outcomes. CONCLUSIONSː The results of our study suggest similar endocrine and metabolic effects of MGB and RYGB procedures. Long-term efficacy and metabolic benefits of MGB require further research.
authors: Department of Clinical Nutrition, Medical University of Gdańsk, Gdańsk, Poland - annadar@gumed.edu.pl.
authors: Jolanta A
authors: JA
authors: Dardzińska
authors: Department of General, Endocrine and Transplant Surgery, Medical University of Gdańsk, Gdańsk, Poland.
authors: Łukasz
authors: Ł
authors: Kaska
authors: Department of General, Endocrine and Transplant Surgery, Medical University of Gdańsk, Gdańsk, Poland.
authors: Piotr
authors: P
authors: Wiśniewski
authors: Department of Clinical Nutrition, Medical University of Gdańsk, Gdańsk, Poland.
authors: Ewa
authors: E
authors: Aleksandrowicz-Wrona
authors: Department of Clinical Nutrition, Medical University of Gdańsk, Gdańsk, Poland.
authors: Sylwia
authors: S
authors: Małgorzewicz
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D005215:Fasting / Q000097:blood; D005260:Female; D015390:Gastric Bypass / Q000379:methods; D006801:Humans; D010535:Laparoscopy / Q000379:methods; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000097:blood / Q000175:diagnosis* / Q000601:surgery*; D019894:Peptide YY / Q000097:blood*; D011182:Postoperative Care; D011237:Predictive Value of Tests; D011300:Preoperative Care; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D016896:Treatment Outcome; D015431:Weight Loss
chemical_list: D015415:Biomarkers; D019894:Peptide YY