title: JAK2 V617F mutation, multiple hematologic and non-hematologic processes: an association?
abstract: BACKGROUND
  Population studies showed that patients with JAK2 V617F mutation had increased mortality, and increased risk of any cancer, hematologic cancer, and myeloproliferative disease.
  
  
  METHODS
  A 68-year-old Asian male with JAK2 V617F mutation developed four different hematologic and non-hematologic neoplastic processes. In 2009, he was diagnosed with stage IA lung adenocarcinoma and also noted to have worsening leukocytosis and thrombocytosis with peak platelet count of 1,054,000/mL). Bone marrow biopsy was consistent with myeloproliferative neoplasm. His monocyte percentage increased in 2011 and met criteria for chronic myelomonocytic leukemia. In 2013, he was admitted for proximal small bowel obstruction, with biopsy confirming stage IE diffuse large B-cell lymphoma. In 2014, a bone marrow biopsy performed for worsening leukocytosis was consistent with acute myeloid leukemia with monocytic differentiation.
  
  
  CONCLUSIONS
  This is a rare case depicting the association of JAK2 V617F mutation with myeloproliferative, lymphoproliferative and solid neoplasms.
authors: Department of Medical Oncology, Montefiore Medical Center, Bronx, NY 10467 USA.
authors: Kenneth G
authors: KG
authors: Liu
authors: Department of Medical Oncology, Montefiore Medical Center, Bronx, NY 10467 USA.
authors: Amit
authors: A
authors: Verma
authors: Department of Medical Oncology, Montefiore Medical Center, Bronx, NY 10467 USA.
authors: Olga
authors: O
authors: Derman
authors: Department of Medical Oncology, Montefiore Medical Center, Bronx, NY 10467 USA.
authors: Noah
authors: N
authors: Kornblum
authors: Department of Medical Oncology, Montefiore Medical Center, Bronx, NY 10467 USA.
authors: Murali
authors: M
authors: Janakiram
authors: Department of Medical Oncology, Montefiore Medical Center, Bronx, NY 10467 USA.
authors: Ira
authors: I
authors: Braunschweig
authors: Department of Medical Oncology, Montefiore Medical Center, Bronx, NY 10467 USA.
authors: Ramakrishna
authors: R
authors: Battini
keywords: Acute myeloid leukemia; Case report; Chronic myelomonocytic leukemia; Diffuse large B-cell lymphoma; JAK2 V617F; Lung adenocarcinoma; Myeloproliferative neoplasm