title: Diagnostic and prognostic roles of serum vitronectin in hepatitis B-related hepatocellular carcinoma.
abstract: BACKGROUND
  Vitronectin (VN) might be involved in the progression of hepatocellular carcinoma (HCC).
  
  
  OBJECTIVE
  This study was designed to evaluate the diagnostic and prognostic value of serum vitronectin among HCC patients.
  
  
  METHODS
  A total of 105 patients with HCC, 91 with liver cirrhosis, 102 with chronic hepatitis, and 100 healthy subjects were recruited. Serum VN and alpha-fetoprotein (AFP) levels were measured.
  
  
  RESULTS
  Serum VN levels were significantly higher in HCC patients than in the other groups. Based on area under receiver operating characteristic curve, serum VN had similar diagnostic value, compared with serum AFP, in distinguishing HCC from the groups, and also improved the diagnostic value of AFP alone. Serum VN levels were associated with the degree of histological differentiation, multiple foci, vascular tumor thrombosis and tumor node metastasis stage. Serum VN was an independent predictor for early recurrence and disease-free survival. Moreover, serum VN possessed similar prognostic predictive performance as compared to serum AFP and also significantly enhanced the prognostic value of AFP alone.
  
  
  CONCLUSIONS
  Elevated serum VN levels represented high diagnostic value and had close relation to clinicopathological factors and early recurrence, suggesting that serum VN might be a useful diagnostic and prognostic marker for HCC.
authors: Department of Hepatopancreatobiliary Surgery, Affiliated Hangzhou Hospital of Nanjing Medical University, Hangzhou First People's Hospital, Hangzhou, Zhejiang, China.
authors: Xiao-Ping
authors: XP
authors: Yang
authors: Department of Hepatopancreatobiliary Surgery, Affiliated Hangzhou Hospital of Nanjing Medical University, Hangzhou First People's Hospital, Hangzhou, Zhejiang, China.
authors: Li-Xing
authors: LX
authors: Zhou
authors: Department of Hepatopancreatobiliary Surgery, Affiliated Hangzhou Hospital of Nanjing Medical University, Hangzhou First People's Hospital, Hangzhou, Zhejiang, China.
authors: Qi-Jun
authors: QJ
authors: Yang
authors: Department of Hepatopancreatobiliary Surgery, Affiliated Hangzhou Hospital of Nanjing Medical University, Hangzhou First People's Hospital, Hangzhou, Zhejiang, China.
authors: Ling
authors: L
authors: Liu
authors: Department of Hepatopancreatobiliary Surgery, Affiliated Hangzhou Hospital of Nanjing Medical University, Hangzhou First People's Hospital, Hangzhou, Zhejiang, China.
authors: Yang
authors: Y
authors: Cai
authors: Department of Oncology, Cancer Institute, Affiliated Hangzhou Hospital of Nanjing Medical University, Hangzhou First People's Hospital, Hangzhou, Zhejiang, China.
authors: Sheng-Lin
authors: SL
authors: Ma
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor; D006528:Carcinoma, Hepatocellular / Q000097:blood* / Q000175:diagnosis / Q000209:etiology* / Q000401:mortality; D016022:Case-Control Studies; D005260:Female; D019694:Hepatitis B, Chronic / Q000150:complications*; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications; D008113:Liver Neoplasms / Q000097:blood* / Q000175:diagnosis / Q000209:etiology* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D011379:Prognosis; D011446:Prospective Studies; D012372:ROC Curve; D019096:Vitronectin / Q000097:blood*; D000509:alpha-Fetoproteins
chemical_list: D014408:Biomarkers, Tumor; D019096:Vitronectin; D000509:alpha-Fetoproteins
keywords: Hepatocellular carcinoma; biomarker; diagnosis; prognosis; vitronectin