title: ABO incompatibility does not influence transfusion requirements in patients undergoing single-unit umbilical cord blood transplantation.
abstract: Hematopoietic stem cell transplantation is usually performed without considering the ABO compatibility between donor and recipient. There are few studies analyzing ABO matching impact on transfusion outcome of umbilical cord blood transplantation (UCBT) recipients. The aim of this study was to analyze factors influencing transfusion outcome, highlighting the ABO matching between donor and recipient. This study has reviewed data from 318 patients who underwent single unit UCBT at la Fe University Hospital from January 2000 to December 2014. There were no differences between RBC and platelet (PLT) requirements or RBC and PLT transfusion independence according to ABO matching between donor and recipient. RBC and PLT requirements were statistically correlated (ρ=0,841, P<0.001). A total of 170 and 188 patients achieved RBC and PLT independence, respectively, within 180 days after UCBT. Persistence of recipient isoagglutinins was detected in 6.8% of patients with major ABO incompatibility at median of 176 days (103-269) after UCBT. Autoimmune haemolytic anemia was diagnosed in 15 patients, 12 of them due to cold antibodies. In conclusion, ABO matching has not influenced transfusion requirements of patients undergoing UCBT.
authors: Blood Bank, Hospital Universitari I Politècnic La Fe Avda Abril Martorell, Valencia, Spain.
authors: P
authors: P
authors: Solves
authors: Blood Bank, Hospital Universitari I Politècnic La Fe Avda Abril Martorell, Valencia, Spain.
authors: N
authors: N
authors: Carpio
authors: Blood Bank, Hospital Universitari I Politècnic La Fe Avda Abril Martorell, Valencia, Spain.
authors: C
authors: C
authors: Carretero
authors: Blood Bank, Hospital Universitari I Politècnic La Fe Avda Abril Martorell, Valencia, Spain.
authors: J I
authors: JI
authors: Lorenzo
authors: Blood Bank, Hospital Universitari I Politècnic La Fe Avda Abril Martorell, Valencia, Spain.
authors: J
authors: J
authors: Sanz
authors: Blood Bank, Hospital Universitari I Politècnic La Fe Avda Abril Martorell, Valencia, Spain.
authors: I
authors: I
authors: Gómez
authors: Blood Bank, Hospital Universitari I Politècnic La Fe Avda Abril Martorell, Valencia, Spain.
authors: F
authors: F
authors: López-Chuliá
authors: Blood Bank, Hospital Universitari I Politècnic La Fe Avda Abril Martorell, Valencia, Spain.
authors: M J
authors: MJ
authors: Arilla
authors: Blood Bank, Hospital Universitari I Politècnic La Fe Avda Abril Martorell, Valencia, Spain.
authors: A I
authors: AI
authors: Regadera
authors: Blood Bank, Hospital Universitari I Politècnic La Fe Avda Abril Martorell, Valencia, Spain.
authors: P
authors: P
authors: Montesinos
authors: Blood Bank, Hospital Universitari I Politècnic La Fe Avda Abril Martorell, Valencia, Spain.
authors: G F
authors: GF
authors: Sanz
authors: Blood Bank, Hospital Universitari I Politècnic La Fe Avda Abril Martorell, Valencia, Spain.
authors: M Á
authors: MÁ
authors: Sanz
mesh_terms: D000017:ABO Blood-Group System; D000293:Adolescent; D000328:Adult; D000368:Aged; D064591:Allografts; D001787:Blood Group Incompatibility; D001788:Blood Grouping and Crossmatching; D036101:Cord Blood Stem Cell Transplantation; D005260:Female; D019337:Hematologic Neoplasms / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D000017:ABO Blood-Group System