title: Statin-associated muscle symptoms: position paper from the Luso-Latin American Consortium.
abstract: In the last two decades, statin therapy has proved to be the most potent isolated therapy for attenuation of cardiovascular risk. Its frequent use has been seen as one of the most important elements for the reduction of cardiovascular mortality in developed countries. However, the recurrent incidence of muscle symptoms in statin users raised the possibility of causal association, leading to a disease entity known as statin associated muscle symptoms (SAMS). Mechanistic studies and clinical trials, specifically designed for the study of SAMS have allowed a deeper understanding of the natural history and accurate incidence. This set of information becomes essential to avoid an unnecessary risk of severe forms of SAMS. At the same time, this concrete understanding of SAMS prevents overdiagnosis and an inadequate suspension of one of the most powerful prevention strategies of our times. In this context, the Luso-Latin American Consortium gathered all available information on the subject and presents them in detail in this document as the basis for the identification and management of SAMS.
authors: a Sociedade Brasileira de Cardiologia , Rio de Janeiro , Brazil.
authors: Andrei C
authors: AC
authors: Sposito
authors: a Sociedade Brasileira de Cardiologia , Rio de Janeiro , Brazil.
authors: José Rocha
authors: JR
authors: Faria Neto
authors: a Sociedade Brasileira de Cardiologia , Rio de Janeiro , Brazil.
authors: Luiz Sergio F de
authors: LS
authors: Carvalho
authors: b Sociedad Argentina de Lípidos , Cordoba , Argentina.
authors: Alberto
authors: A
authors: Lorenzatti
authors: b Sociedad Argentina de Lípidos , Cordoba , Argentina.
authors: Alberto
authors: A
authors: Cafferata
authors: b Sociedad Argentina de Lípidos , Cordoba , Argentina.
authors: Gerardo
authors: G
authors: Elikir
authors: b Sociedad Argentina de Lípidos , Cordoba , Argentina.
authors: Eduardo
authors: E
authors: Esteban
authors: c Sociedad Mexicana de Cardiologia , Tlalpan , Federal District , Mexico.
authors: Enrique C
authors: EC
authors: Morales Villegas
authors: a Sociedade Brasileira de Cardiologia , Rio de Janeiro , Brazil.
authors: Luiz Carlos
authors: LC
authors: Bodanese
authors: d Asociación Chilena de Nutrición Clínica , Santiago , Chile.
authors: Rodrigo
authors: R
authors: Alonso
authors: e Soceidad Colombiana de Cardiolgia Y Cirgugia Cardiovascular , Bogota , Colombia.
authors: Alvaro J
authors: AJ
authors: Ruiz
authors: a Sociedade Brasileira de Cardiologia , Rio de Janeiro , Brazil.
authors: Viviane Z
authors: VZ
authors: Rocha
authors: a Sociedade Brasileira de Cardiologia , Rio de Janeiro , Brazil.
authors: André A
authors: AA
authors: Faludi
authors: a Sociedade Brasileira de Cardiologia , Rio de Janeiro , Brazil.
authors: Hermes T
authors: HT
authors: Xavier
authors: a Sociedade Brasileira de Cardiologia , Rio de Janeiro , Brazil.
authors: Otávio Rizzi
authors: OR
authors: Coelho
authors: a Sociedade Brasileira de Cardiologia , Rio de Janeiro , Brazil.
authors: Marcelo H V
authors: MH
authors: Assad
authors: a Sociedade Brasileira de Cardiologia , Rio de Janeiro , Brazil.
authors: Maria C
authors: MC
authors: Izar
authors: a Sociedade Brasileira de Cardiologia , Rio de Janeiro , Brazil.
authors: Raul D
authors: RD
authors: Santos
authors: a Sociedade Brasileira de Cardiologia , Rio de Janeiro , Brazil.
authors: Francisco A H
authors: FA
authors: Fonseca
authors: f Sociedade Portuguesa de Aterosclerose , Lisboa , Portugal.
authors: Alberto
authors: A
authors: Mello E Silva
authors: f Sociedade Portuguesa de Aterosclerose , Lisboa , Portugal.
authors: Pedro Marques da
authors: PM
authors: Silva
authors: a Sociedade Brasileira de Cardiologia , Rio de Janeiro , Brazil.
authors: Marcelo C
authors: MC
authors: Bertolami
mesh_terms: D002318:Cardiovascular Diseases / Q000517:prevention & control*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D009135:Muscular Diseases / Q000139:chemically induced*; D012307:Risk Factors
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors
keywords: Intolerance; statin; statin associated muscle symptoms