title: Anethole and Its Role in Chronic Diseases.
abstract: Anethole is the main fragrance and bioactive compound of anise, fennel, and star anise spices and more than other 20 plant species. It is widely used as flavor agent in food industry and other industries, in cosmetics, perfumery, and pharmaceuticals. In the last few years, various studies have revealed multiple beneficial effects of anethole for human health, such as anti-inflammatory, anticarcinogenic and chemopreventive, antidiabetic, immunomodulatory, neuroprotective, or antithrombotic, that are mediated by the modulation of several cell signaling pathways, mainly NF-kB and TNF-α signaling, and various ion channels. This chapter aims to review the scientific data and attempts to provide an insight into pharmacological activity of anethole and its therapeutic potential in human chronic diseases.
authors: Department of Pharmacognosy, Faculty of Pharmacy, University of Medicine and Pharmacy "Grigore T. Popa", Iasi, Romania. anaclara70@yahoo.com.
authors: Ana Clara
authors: AC
authors: Aprotosoaie
authors: Department of Internal Medicine, Faculty of Medicine, "Sf. Spiridon" University Hospital Iasi, University of Medicine and Pharmacy "Grigore T. Popa", Iasi, Romania.
authors: Irina-Iuliana
authors: II
authors: Costache
authors: Department of Pharmacognosy, Faculty of Pharmacy, University of Medicine and Pharmacy "Grigore T. Popa", Iasi, Romania.
authors: Anca
authors: A
authors: Miron
mesh_terms: D000081248:Allylbenzene Derivatives; D000818:Animals; D000840:Anisoles / Q000493:pharmacokinetics / Q000627:therapeutic use*; D000893:Anti-Inflammatory Agents / Q000493:pharmacokinetics / Q000627:therapeutic use*; D000972:Antineoplastic Agents, Phytogenic / Q000493:pharmacokinetics / Q000627:therapeutic use*; D002908:Chronic Disease / Q000188:drug therapy*; D055808:Drug Discovery / Q000379:methods*; D006801:Humans; D015394:Molecular Structure; D008517:Phytotherapy; D010946:Plants, Medicinal; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D000081248:Allylbenzene Derivatives; D000840:Anisoles; D000893:Anti-Inflammatory Agents; D000972:Antineoplastic Agents, Phytogenic; C006578:anethole
keywords: AP-1 signaling pathways; Anethole; Anti-inflammatory; Anticarcinogenic; MAPK; NF-kB; STAT; TNF-α