title: Intraoperative radiotherapy for the treatment of thyroid cancer: a pilot study.
abstract: We preliminarily evaluated the clinical feasibility and efficacy of intraoperative radiotherapy in patients with thyroid carcinoma. Nine thyroid cancer patients received intraoperative radiotherapy using an Intrabeam system. The dose was 3-4 Gy and the irradiation time ranged from 1 min 32 s to 7 min 33s. One case was a primary thyroid carcinoma, while the other cases were recurrent disease. Adverse effects, recurrence and survival were analyzed. In one patient, poorly differentiated thyroid carcinoma recurred 5 months after treatment, one patient developed a postoperative tracheal skin fistula, and one patient developed a wound infection. Because the affected areas were treated with both surgical resection and then radiotherapy, it is difficult to know which of those led to the adverse effects. Nonetheless, our results indicate that intraoperative radiotherapy can relieve the symptoms associated with thyroid cancer and improve the quality of life for these patients. It thus appears feasible to treat thyroid cancer patients with intraoperative radiotherapy.
authors: Department of Radiation Oncology, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, China.
authors: Pei-Qiang
authors: PQ
authors: Yi
authors: Department of Radiation Oncology, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, China.
authors: Fang-Fang
authors: FF
authors: Nie
authors: Department of Surgery, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, China.
authors: You-Ben
authors: YB
authors: Fan
authors: Department of Radiation Oncology, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, China.
authors: Wei-Wei
authors: WW
authors: Yu
authors: Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.|Department of Oncology, Shanghai Medical College, Shanghai, China.
authors: Chao-Su
authors: CS
authors: Hu
authors: Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.|Shanghai Medical College, Fudan University, Shanghai, China.
authors: Xiao-Mao
authors: XM
authors: Guo
authors: Department of Radiation Oncology, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, China.
authors: Jie
authors: J
authors: Fu
mesh_terms: D005260:Female; D006801:Humans; D007430:Intraoperative Care / Q000379:methods*; D008297:Male; D010865:Pilot Projects; D015996:Survival Rate; D013964:Thyroid Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*
keywords: adverse reactions; intraoperative radiotherapy; pilot study; radiation therapy; thyroid cancer