title: The interaction between physical activity and obesity gene variants in association with BMI: Does the obesogenic environment matter?
abstract: Little is known about how obesity susceptibility single nucleotide polymorphisms (SNPs) interact with moderate to vigorous physical activity (MVPA) in relation to BMI during adolescence, once obesogenic neighborhood factors are accounted for. In race stratified models, including European (EA; N=4977), African (AA; N=1726), and Hispanic Americans (HA; N=1270) from the National Longitudinal Study of Adolescent to Adult Health (1996; ages 12-21), we assessed the evidence for a SNPxMVPA interaction with BMI-for-age Z score, once accounting for obesogenic neighborhood factors including physical activity amenities, transportation and recreation infrastructure, poverty and crime. Eight SNPxMVPA interactions with suggestive significance (p<0.10; three in each EA, and AA, two in HA) were observed showing attenuation on BMI-for-age Z score in adolescents with ≥5 versus <5 bouts/week MVPA, except for rs10146997 (near NRXN3). Findings were robust to the inclusion of neighborhood-level variables as covariates. These findings suggest that any attenuation from MVPA on a genetic susceptibility to obesity during adolescence is likely not operating through obesogenic neighborhood factors.
authors: Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27514 USA. Electronic address: migraff@email.unc.edu.
authors: M
authors: M
authors: Graff
authors: RAND Corporation, Santa Monica, CA 90401 USA.
authors: A S
authors: AS
authors: Richardson
authors: Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27514 USA; Carolina Population Center, University of North Carolina, Chapel Hill, NC 27514 USA.
authors: K L
authors: KL
authors: Young
authors: Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27514 USA.
authors: A L
authors: AL
authors: Mazul
authors: Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27514 USA.
authors: Heather
authors: H
authors: Highland
authors: Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27514 USA; Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, NC 27514 USA.
authors: K E
authors: KE
authors: North
authors: Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, NC 27514 USA; Department of Genetics, University of North Carolina, Chapel Hill, NC 27514 USA.
authors: K L
authors: KL
authors: Mohlke
authors: Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, NC 27514 USA; Department of Genetics, University of North Carolina, Chapel Hill, NC 27514 USA.
authors: L A
authors: LA
authors: Lange
authors: Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, NC 27514 USA; Department of Genetics, University of North Carolina, Chapel Hill, NC 27514 USA.
authors: E M
authors: EM
authors: Lange
authors: Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27514 USA; Department of Sociology, Univlersity of North Carolina, Chapel Hill, NC 27514 USA.
authors: K M
authors: KM
authors: Harris
authors: Carolina Population Center, University of North Carolina, Chapel Hill, NC 27514 USA; Department of Nutrition Gillings School of Global Public Health & School of Medicine, University of North Carolina, Chapel Hill, NC 27514 USA.
authors: P
authors: P
authors: Gordon-Larsen
mesh_terms: D000293:Adolescent; D000328:Adult; D001741:Black or African American / Q000706:statistics & numerical data; D015992:Body Mass Index; D002648:Child; D004777:Environment; D015444:Exercise; D005260:Female; D059647:Gene-Environment Interaction; D040362:Geographic Information Systems; D006630:Hispanic or Latino / Q000706:statistics & numerical data; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D009765:Obesity / Q000453:epidemiology*; D012111:Residence Characteristics; D014186:Transportation; D014481:United States; D044465:White People / Q000706:statistics & numerical data; D055815:Young Adult
keywords: Adolescence; African and Hispanic American; BMI; Genetics of obesity; Physical activity