title: Nickel exposure and plasma levels of biomarkers for assessing oxidative stress in nickel electroplating workers.
abstract: BACKGROUND
  The mechanism of nickel-induced pathogenesis remains elusive.
  
  
  OBJECTIVE
  To examine effects of nickel exposure on plasma oxidative and anti-oxidative biomarkers.
  
  
  METHODS
  Biomarker data were collected from 154 workers with various levels of nickel exposure and from 73 controls. Correlations between nickel exposure and oxidative and anti-oxidative biomarkers were determined using linear regression models.
  
  
  RESULTS
  Workers with a exposure to high nickel levels had significantly lower levels of anti-oxidants (glutathione and catalase) than those with a lower exposure to nickel; however, only glutathione showed an independent association after multivariable adjustment.
  
  
  CONCLUSIONS
  Exposure to high levels of nickel may reduce serum anti-oxidative capacity.
authors: a Department of Occupational Medicine , Chang Gung Memorial Hospital , Taoyuan , Taiwan.|b Department of Occupational Medicine , Chang Gung Memorial Hospital , Chiayi , Taiwan.|c Department of Family Medicine , Chang Gung Memorial Hospital , Taoyuan , Taiwan.|d College of Medicine , Chang Gung University , Taoyuan , Taiwan.
authors: Yu-Chung
authors: http://orcid.org/0000-0001-7355-5208
authors: YC
authors: Tsao
authors: d College of Medicine , Chang Gung University , Taoyuan , Taiwan.|e Department of Laboratory Medicine , Chang Gung Medical Center , Taoyuan , Taiwan.
authors: Po-Wen
authors: PW
authors: Gu
authors: c Department of Family Medicine , Chang Gung Memorial Hospital , Taoyuan , Taiwan.|d College of Medicine , Chang Gung University , Taoyuan , Taiwan.
authors: Su-Hsun
authors: http://orcid.org/0000-0002-1151-7983
authors: SH
authors: Liu
authors: f Department of Emergency Medicine , Chang Gung Memorial Hospital , Taoyuan , Taiwan.|g Institute of Epidemiology and Preventive Medicine, National Taiwan University , Taipei , Taiwan.
authors: I-Shiang
authors: http://orcid.org/0000-0002-9047-8141
authors: IS
authors: Tzeng
authors: c Department of Family Medicine , Chang Gung Memorial Hospital , Taoyuan , Taiwan.|d College of Medicine , Chang Gung University , Taoyuan , Taiwan.
authors: Jau-Yuan
authors: JY
authors: Chen
authors: a Department of Occupational Medicine , Chang Gung Memorial Hospital , Taoyuan , Taiwan.|d College of Medicine , Chang Gung University , Taoyuan , Taiwan.
authors: Jiin-Chyuan John
authors: JJ
authors: Luo
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000032:analysis; D015415:Biomarkers / Q000097:blood; D002374:Catalase / Q000097:blood; D004595:Electroplating; D005978:Glutathione / Q000097:blood; D006801:Humans; D009532:Nickel / Q000009:adverse effects*; D016273:Occupational Exposure / Q000032:analysis*; D018384:Oxidative Stress / Q000187:drug effects*; D055815:Young Adult
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D009532:Nickel; D002374:Catalase; D005978:Glutathione
keywords: Nickel; biomarkers; oxidative stress