title: ACE inhibitors, left ventricular mass and renal cyst growth in ADPKD.
abstract: The review focuses on the common kidney disorder of Autosomal Dominant Polycystic Kidney Disease (ADPKD). The potential pathogenetic role of the renin-angiotensin-aldosterone system (RAAS) in the renal cyst growth, the accompanying hypertension, and the frequency of increased left ventricular mass is considered. The therapeutic benefit of angiotensin converting enzyme inhibition (ACEI) in diminishing the renal cyst growth, treatment of the hypertension, and reversing the increased left ventricular mass in ADPKD is supportive of this possibility. The effects of ACEI related and unrelated to control of blood pressure are discussed.
authors: University of Colorado School of Medicine, University of Colorado Denver School of Medicine, Department of Medicine Division of Renal Diseases and Hypertension 12077 East 19th Avenue, C281 Research Building 2, Room 7001 Aurora, CO 80045, United States. Electronic address: robert.schrier@ucdenver.edu.
authors: Robert W
authors: RW
authors: Schrier
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D006352:Heart Ventricles / Q000187:drug effects / Q000473:pathology; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D007668:Kidney / Q000187:drug effects* / Q000473:pathology; D016891:Polycystic Kidney, Autosomal Dominant / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D012084:Renin-Angiotensin System / Q000187:drug effects*
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors
keywords: Enalapril; Kidney; Renin-angiotensin-aldosterone system