title: New polymorphism of the influenza virus resistanceMx1gene in Iberian domestic pigs.
abstract: Mx1(Myxovirus (Influenza virus) resistance 1, interferon-inducible protein p78) gene has been implicated in the resistance to a wide range of RNA viruses including influenza A in several species such asSus scrofa. In the present study a 28-bp deletion in exon 14 of theMx1gene has been identified in Iberian domestic pigs but not in other domestic breeds neither in wild boars. The mutation produces a frameshift giving a protein with 6 amino acid substitutions and the extension of the C-terminal region with additional 20 amino acids with respect to the wild type MX1 protein. The new allelic polymorphism affects the antiviral domain of the MX1 protein and therefore might impact its anti-influenza virus activity. It has been demonstrated that polymorphisms in theMx1murine locus, affect the survival rate of mice upon experimental infection with influenza virus. It might be possible to improve the innate resistance of pigs to influenza virus infection by determining the porcineMx1alleles with more potent antiviral activity and genetically selecting animals bearing such alleles.
authors: Department of Ophthalmology, Ocular Genomics Institute-Harvard Medical School, MEEI, Boston, MA. USA.
authors: R F
authors: RF
authors: Godino
authors: Dpto Biotecnología1 y Mejora Genética2, INIA. Madrid, Spain.
authors: A I
authors: AI
authors: Fernández
keywords: Iberian pigs; Influenza resistance; Mx1; polymorphisms