title: Pain evaluation during gynaecological surveillance in women with Lynch syndrome.
abstract: To evaluate perceived pain during repetitive annual endometrial sampling at gynaecologic surveillance in asymptomatic women with Lynch syndrome (LS) over time and in addition to symptomatic women without LS, undergoing single endometrial sampling. In this prospective study, 52 women with LS or first degree relatives who underwent repetitive annual gynaecological surveillance including endometrial sampling of which 33 were evaluated twice or more and 50 symptomatic women without LS who had single endometrial sampling, were included. Pain intensity was registered with VAS scores. Differences in pain intensities between subsequent visits (in LS) and between the two groups were evaluated. The use of painkillers before endometrial sampling was registered. If women with LS decided for preventive surgery, the reason was recorded. The LS group reported a median VAS score of 5.0 (range 0-10) at the first surveillance (n = 52) and at the second visit (n = 24). Women who repeatedly underwent endometrial sampling more often used painkillers for this procedure. During the study period 7/52 (13 %) women with LS choose for preventive surgery, another 4/52 (8 %) refused further endometrial sampling. Painful endometrial sampling was mentioned as main reason to quit screening. The median VAS score of the 50 symptomatic women was 5.0 (range 1-9). Endometrial sampling, irrespective of indication, is a painful procedure, with a median VAS score of 5.0. During subsequent procedures in women with LS, the median pain score does not aggravate although one in five women chose an alternative for endometrial sampling.
authors: University Medical Center Groningen, Groningen, The Netherlands. j.helder-woolderink@mzh.nl.|Martini Hospital, Groningen, The Netherlands. j.helder-woolderink@mzh.nl.
authors: Jorien
authors: 0000-0003-4045-2151
authors: J
authors: Helder-Woolderink
authors: University Medical Center Groningen, Groningen, The Netherlands.
authors: Geertruida
authors: G
authors: de Bock
authors: University Medical Center Groningen, Groningen, The Netherlands.
authors: Harry
authors: H
authors: Hollema
authors: Martini Hospital, Groningen, The Netherlands.
authors: Magda
authors: M
authors: van Oven
authors: University Medical Center Groningen, Groningen, The Netherlands.
authors: Marian
authors: M
authors: Mourits
mesh_terms: D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D001706:Biopsy / Q000009:adverse effects; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000235:genetics* / Q000601:surgery; D055088:Early Detection of Cancer / Q000379:methods*; D016889:Endometrial Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D004717:Endometrium / Q000473:pathology; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008875:Middle Aged; D010146:Pain / Q000188:drug therapy* / Q000209:etiology; D010147:Pain Measurement; D065286:Prophylactic Surgical Procedures; D011446:Prospective Studies
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal
keywords: Endometrial cancer; Endometrial sampling; Lynch syndrome; Pain; Surveillance; VAS score