title: NO Photoreleaser-Deoxyadenosine and -Bile Acid Derivative Bioconjugates as Novel Potential Photochemotherapeutics.
abstract: This contribution reports the synthesis of some novel bioconjugates with anticancer activity and able to release nitric oxide (NO) under visible light excitation. The 4-nitro-2-(trifluoromethyl)aniline derivative, a suitable NO photodonor, was conjugated with 2'-deoxyadenosine and urso- and cheno-deoxycholic acid derivatives, through a thioalkylic chain or the 4-alkyl-1,2,3-triazole moiety. Photochemical experiments demonstrated the effective release of NO from 2'-deoxyadenosine and ursodeoxycholic acid conjugates under the exclusive control of visible light inputs. Studies for thein vitroantiproliferative activity against leukemic K562 and colon carcinoma HCT116 cell lines are reported for all the compounds as well as a case study of photocytotoxicity against HCT116.
authors: ISOF-CNR , via P. Gobetti, 101, 40129 Bologna, Italy.
authors: Maria Luisa
authors: ML
authors: Navacchia
authors: Laboratory of Photochemistry, Department of Drug Sciences, University of Catania , 95125 Catania, Italy.
authors: Aurore
authors: A
authors: Fraix
authors: Department of Chemical and Pharmaceutical Sciences, University of Ferrara , via L. Borsari, 46, 44121 Ferrara, Italy.
authors: Nicola
authors: N
authors: Chinaglia
authors: Department of Medical Sciences, University of Ferrara , corso Giovecca, 203, 44121 Ferrara, Italy.
authors: Eleonora
authors: E
authors: Gallerani
authors: Department of Chemical and Pharmaceutical Sciences, University of Ferrara , via L. Borsari, 46, 44121 Ferrara, Italy.
authors: Daniela
authors: D
authors: Perrone
authors: Department of Bio-Medical and Biotechnological Sciences, Physiology Division, University of Catania , I-95125 Catania, Italy.
authors: Venera
authors: V
authors: Cardile
authors: Department of Bio-Medical and Biotechnological Sciences, Physiology Division, University of Catania , I-95125 Catania, Italy.
authors: Adriana C E
authors: AC
authors: Graziano
authors: ISOF-CNR , via P. Gobetti, 101, 40129 Bologna, Italy.
authors: Massimo L
authors: ML
authors: Capobianco
authors: Laboratory of Photochemistry, Department of Drug Sciences, University of Catania , 95125 Catania, Italy.
authors: Salvatore
authors: S
authors: Sortino
keywords: 2′-deoxyadenosine conjugates; NO photorelease; bile acid conjugates; photochemotherapeutics