title: [Manifestations of PET/CT Imaging in Primary Central Nervous System Lymphoma].
abstract: OBJECTIVE
  To investigate the PET/CT features of primary central nervous system lymphoma(PCNSL).
  
  
  METHODS
  A retrospective analysis of PET/CT imaging manifestations and clinical data was performed in 4 PCNSL cases which were confirmed by surgery or stereotactic pathologic biopsy.
  
  
  RESULTS
  The pathologic biopsy in 4 patients all showed diffuse large B cell lymphoma with a total of 8 lesions. All cases were performed with18F-FDG PET/CT imaging except 1 patient simultaneously with18F-FLT PET/CT imaging in the brain. Single lesion was found in 2 cases which both were located in the left frontal lobe. Multiple lesions were found in 2 cases, out of them 1 case located in the corpus callosum and the right lateral ventricle Angle, and the other 1 located in dual lateral ventricle and pineal region. In18F-FDG PET/CT image, 4 patients were characterized by high metabolism, even higher than the surrounding brain tissue. The patient which underwent18F-FLT PET/CT imaging was also presented with high metabolism and had better Target and non-target ratio(T/N). 3 cases with surrounded by edema and 2 cases with area of cystic necrosis.
  
  
  CONCLUSIONS
  PCNSL are characterized by high metabolism in18F-FDG PET/CT images and can better contrast with the surrounding normal brain. Combined use of other tracer such as18F-FLT can improve the diagnostic value of PET/CT in PCNSL.
authors: Department of Nuclear Medicine, The Affiliated Hospital, Logistic College of Chinese People's Armed Police Force, Tianjin 300162, China.
authors: Liang
authors: L
authors: Yin
authors: Department of Nuclear Medicine, The Affiliated Hospital, Logistic College of Chinese People's Armed Police Force, Tianjin 300162, China. E-mail: zhichunlin@163.com.
authors: Zhi-Chun
authors: ZC
authors: Lin
authors: Department of Nuclear Medicine, The Affiliated Hospital, Logistic College of Chinese People's Armed Police Force, Tianjin 300162, China.
authors: Jian-Lan
authors: JL
authors: Yue
authors: Department of Nuclear Medicine, The Affiliated Hospital, Logistic College of Chinese People's Armed Police Force, Tianjin 300162, China.
authors: Shi-Ming
authors: SM
authors: Huang
authors: Department of Nuclear Medicine, The Affiliated Hospital, Logistic College of Chinese People's Armed Police Force, Tianjin 300162, China.
authors: Wei
authors: W
authors: Chen
mesh_terms: D001706:Biopsy; D016543:Central Nervous System Neoplasms; D019788:Fluorodeoxyglucose F18; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse; D000072078:Positron Emission Tomography Computed Tomography; D049268:Positron-Emission Tomography; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D040281:Vascular Endothelial Growth Factor Receptor-1
chemical_list: D019788:Fluorodeoxyglucose F18; C501162:FLT1 protein, human; D040281:Vascular Endothelial Growth Factor Receptor-1