title: Overnight Changes in Lung Function of Obese Patients with Obstructive Sleep Apnoea.
abstract: Obstructive sleep apnoea (OSA) is a prevalent disorder, characterised by collapse of the upper airways during sleep. The impact of sleep-disordered breathing on pulmonary function indices is however currently not well described. The aim of the study was to evaluate diurnal change in lung function indices in a cohort of patients with OSA and relate pulmonary function changes to disease severity.
  
  
  
  42 patients with OSA and 73 healthy control subjects participated in the study. Asthma and COPD were excluded in all volunteers following a clinical and spirometric assessment. Spirometry was then performed in all subjects in the evening and the morning following a polysomnography study.
  
  
  
  There was no difference in evening or morning FEV1or FVC between patients and control subjects (p > 0.05). Neither FEV1nor FVC changed in control subjects overnight (p > 0.05). In contrast, FEV1significantly increased from evening (2.18/1.54-4.46/L) to morning measurement (2.26/1.42-4.63/L) in OSA without any change in FVC. The FEV1increase in OSA was related to male gender, obesity and the lack of treatment with statins or β-blockers (all p < 0.05). A tendency for a direct correlation was apparent between overnight FEV1change and RDI (p = 0.05, r = 0.30).
  
  
  
  Diurnal variations in spirometric indices occur in patients with OSA and FEV1appears to increase in subjects with OSA overnight. These changes occur in the absence of change in FVC and are directly related to the severity of OSA. These findings dictate a need to consider time of lung function measurement.
authors: Department of Pulmonology, Semmelweis University, 1/C Dios arok, Budapest, 1125, Hungary.
authors: Laszlo
authors: L
authors: Kunos
authors: Department of Pulmonology, Semmelweis University, 1/C Dios arok, Budapest, 1125, Hungary.
authors: Zsofia
authors: Z
authors: Lazar
authors: Department of Pulmonology, Semmelweis University, 1/C Dios arok, Budapest, 1125, Hungary.
authors: Fruzsina
authors: F
authors: Martinovszky
authors: Department of Radiology and Oncotherapy, Semmelweis University, 78a Ulloi ut, Budapest, 1082, Hungary.
authors: Adam D
authors: AD
authors: Tarnoki
authors: Department of Radiology and Oncotherapy, Semmelweis University, 78a Ulloi ut, Budapest, 1082, Hungary.
authors: David L
authors: DL
authors: Tarnoki
authors: Department of Radiology and Oncotherapy, Semmelweis University, 78a Ulloi ut, Budapest, 1082, Hungary.
authors: Daniel
authors: D
authors: Kovacs
authors: Department of Radiology and Oncotherapy, Semmelweis University, 78a Ulloi ut, Budapest, 1082, Hungary.
authors: Bianka
authors: B
authors: Forgo
authors: Department of Pulmonology, Semmelweis University, 1/C Dios arok, Budapest, 1125, Hungary.
authors: Peter
authors: P
authors: Horvath
authors: Department of Pulmonology, Semmelweis University, 1/C Dios arok, Budapest, 1125, Hungary.
authors: Gyorgy
authors: G
authors: Losonczy
authors: Department of Pulmonology, Semmelweis University, 1/C Dios arok, Budapest, 1125, Hungary. andras.bikov@gmail.com.
authors: Andras
authors: A
authors: Bikov
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D001794:Blood Pressure; D016022:Case-Control Studies; D005260:Female; D005541:Forced Expiratory Volume; D006339:Heart Rate; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000503:physiopathology*; D017286:Polysomnography; D012720:Severity of Illness Index; D012737:Sex Factors; D020181:Sleep Apnea, Obstructive / Q000150:complications / Q000503:physiopathology*; D013997:Time Factors; D014797:Vital Capacity; D055815:Young Adult
chemical_list: D000319:Adrenergic beta-Antagonists; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors
keywords: Forced expiratory volume in 1 s; Lung function; Obstructive sleep apnoea; Overnight changes