title: Paracrine Signaling in the Prostatic Stroma: A Novel Role for the Telocytes Revealed in Rodents' Ventral Prostate.
abstract: The telocytes have recently been described in the prostate gland. In mature gland, they exist in close association with the acini and their telopodes form networks whose functions remain unclear. In this chapter, our group gives a brief introduction to telocytes and explores the history that led to such a concept and then discusses hypotheses and presents new evidences about the roles exerted by telocytes in the prostate. First is given emphasis on the role that these cells possibly play in paracrine signaling employed in the differentiation of smooth muscle periacinar are then discussed other roles potentially performed by telocytes in the prostate, such as the organizational, where these cells would act in order to delimit stromal microenvironments, thereby assisting the differentiation of the prostatic anatomical components. In addition, the pacemaker function of smooth muscle cells contraction, as evidenced by the presence of caveolae and gap-type junction and, finally, the role of telocytes in prostate remodeling and the possible action as adult progenitor cells. Generally speaking, the chapter reaffirms the existence of telocytes as distinct cells of other stromal cells and the importance of this new cell type for normal metabolism and prostate development.
authors: Department of Structural and Functional Biology, State University of Campinas - UNICAMP, Bertrand Russel Av. s/n, Campinas, São Paulo, Brazil.|Laboratory of Microscopy and Microanalysis, Department of Biology, Univ. Estadual Paulista - UNESP, Cristóvão Colombo St., 2265, Jardim Nazareth, São José do Rio Preto, São Paulo, Brazil.
authors: Bruno D A
authors: BD
authors: Sanches
authors: Laboratory of Microscopy and Microanalysis, Department of Biology, Univ. Estadual Paulista - UNESP, Cristóvão Colombo St., 2265, Jardim Nazareth, São José do Rio Preto, São Paulo, Brazil.|Campus de Araguaína - Escola de Medicina Veterinária e Zootecnia, Fund. Univ. Federal do Tocantins, BR 153 Km112, Araguaína, TO, Brazil.
authors: Lara S
authors: LS
authors: Corradi
authors: Laboratory of Microscopy and Microanalysis, Department of Biology, Univ. Estadual Paulista - UNESP, Cristóvão Colombo St., 2265, Jardim Nazareth, São José do Rio Preto, São Paulo, Brazil.|Campus de Araguaína - Escola de Medicina Veterinária e Zootecnia, Fund. Univ. Federal do Tocantins, BR 153 Km112, Araguaína, TO, Brazil.
authors: Patricia S L
authors: PS
authors: Vilamaior
authors: Department of Structural and Functional Biology, State University of Campinas - UNICAMP, Bertrand Russel Av. s/n, Campinas, São Paulo, Brazil. taboga@ibilce.unesp.br.|Laboratory of Microscopy and Microanalysis, Department of Biology, Univ. Estadual Paulista - UNESP, Cristóvão Colombo St., 2265, Jardim Nazareth, São José do Rio Preto, São Paulo, Brazil. taboga@ibilce.unesp.br.
authors: Sebastião R
authors: SR
authors: Taboga
mesh_terms: D000818:Animals; D018952:Antigens, CD34 / Q000235:genetics / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism; D002454:Cell Differentiation; D003238:Connective Tissue / Q000378:metabolism*; D005260:Female; D051526:Fibroblast Growth Factor 10 / Q000235:genetics / Q000378:metabolism; D005347:Fibroblasts / Q000166:cytology / Q000378:metabolism*; D017629:Gap Junctions / Q000378:metabolism / Q000648:ultrastructure; D015870:Gene Expression; D005849:Gerbillinae / Q000033:anatomy & histology / Q000502:physiology*; D008297:Male; D032389:Myocytes, Smooth Muscle / Q000166:cytology / Q000378:metabolism*; D019899:Paracrine Communication / Q000502:physiology*; D011467:Prostate / Q000166:cytology / Q000378:metabolism*; D012737:Sex Factors; D013045:Species Specificity; D000067170:Telocytes / Q000166:cytology / Q000378:metabolism*; D053773:Transforming Growth Factor beta1 / Q000235:genetics / Q000378:metabolism
chemical_list: D018952:Antigens, CD34; D015415:Biomarkers; D051526:Fibroblast Growth Factor 10; D053773:Transforming Growth Factor beta1
keywords: Epithelium-stroma interaction; Paracrine signaling; Prostate development; Prostatic stroma; Ventral prostate