title: Multifunctional Cu2-xTe Nanocubes Mediated Combination Therapy for Multi-Drug Resistant MDA MB 453.
abstract: Hypermethylated cancer populations are hard to treat due to their enhanced chemo-resistance, characterized by aberrant methylated DNA subunits. Herein, we report on invoking response from such a cancer lineage to chemotherapy utilizing multifunctional copper telluride (Cu2-XTe) nanocubes (NCs) as photothermal and photodynamic agents, leading to significant anticancer activity. The NCs additionally possessed photoacoustic and X-ray contrast imaging abilities that could serve in image-guided therapeutic studies.
authors: Bio Nano Electronics Research Centre, Graduate School of Interdisciplinary New Science, Toyo University, Kawagoe, 350-8585, Japan.
authors: Aby Cheruvathoor
authors: AC
authors: Poulose
authors: Bio Nano Electronics Research Centre, Graduate School of Interdisciplinary New Science, Toyo University, Kawagoe, 350-8585, Japan.
authors: Srivani
authors: S
authors: Veeranarayanan
authors: Bio Nano Electronics Research Centre, Graduate School of Interdisciplinary New Science, Toyo University, Kawagoe, 350-8585, Japan.
authors: M Sheikh
authors: MS
authors: Mohamed
authors: Department of Imaging Physics, University of Texas MD Anderson Cancer Center, Houston, TX, 77054, USA.
authors: Rebeca Romero
authors: RR
authors: Aburto
authors: Department of Imaging Physics, University of Texas MD Anderson Cancer Center, Houston, TX, 77054, USA.
authors: Trevor
authors: T
authors: Mitcham
authors: Department of Imaging Physics, University of Texas MD Anderson Cancer Center, Houston, TX, 77054, USA.
authors: Richard R
authors: RR
authors: Bouchard
authors: Department of Material Science and Nano Engineering, Rice University, 6100 Main Street, Houston, TX, 77005, USA.
authors: Pulickel M
authors: PM
authors: Ajayan
authors: Biomedical Research Centre, Division of Analytical Science, Saitama Medical University, Saitama, 350-0495, Japan.
authors: Yasushi
authors: Y
authors: Sakamoto
authors: Bio Nano Electronics Research Centre, Graduate School of Interdisciplinary New Science, Toyo University, Kawagoe, 350-8585, Japan.
authors: Toru
authors: T
authors: Maekawa
authors: Bio Nano Electronics Research Centre, Graduate School of Interdisciplinary New Science, Toyo University, Kawagoe, 350-8585, Japan.
authors: D Sakthi
authors: DS
authors: Kumar
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001943:Breast Neoplasms / Q000188:drug therapy*; D045744:Cell Line, Tumor; D003287:Contrast Media / Q000008:administration & dosage; D003300:Copper / Q000008:administration & dosage; D004337:Drug Carriers / Q000008:administration & dosage*; D018432:Drug Resistance, Multiple; D004359:Drug Therapy, Combination / Q000379:methods*; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods; D008954:Models, Biological; D049329:Nanostructures / Q000008:administration & dosage*; D061088:Photoacoustic Techniques; D010778:Photochemotherapy / Q000379:methods; D017319:Photosensitizing Agents; D013691:Tellurium / Q000008:administration & dosage; D000068936:Theranostic Nanomedicine; D014965:X-Rays
chemical_list: D000970:Antineoplastic Agents; D003287:Contrast Media; D004337:Drug Carriers; D017319:Photosensitizing Agents; D003300:Copper; C026660:tellurous acid; D013691:Tellurium