title: Disrupted Brain Structural Connectivity: Pathological Interactions Between Genetic APOE ε4 Status and Developed MCI Condition.
abstract: The ε4 allele of the apolipoprotein E (APOE) gene and mild cognitive impairment (MCI) are both risk factors for Alzheimer's disease (AD). One factor is genetic, and the other is a developed condition during the aging process. The current study intended to discover the interactions of these two factors, which may be useful in the construction of a sensitive biomarker for early identification and intervention. Eight hundred eighty-five Chinese Han ethnic subjects (aged 55 and older) completed neuropsychological tests and APOE genotyping. One hundred ten of these participants underwent magnetic resonance imaging (MRI) for T1 structural and diffusion tensor imaging scans. Subjects were divided into four groups according to APOE ε4 carrying status and MCI condition: ε4+ MCI, ε4+ normal cognition (NC), ε4- MCI, and ε4- NC. In the studied Han population in Beijing, 16.9 % (ε2ε4 = 1.1 %, ε3ε4 = 14.8 %, and ε4ε4 = 0.9 %) carried at least one ε4 allele. Significant interactions between APOE ε4 and MCI were found in general cognitive function (p = 0.001) and white matter connectivity network (clustering coefficient, p = 0.004, and local efficiency, p = 0.011); the combination of ε4 positivity and MCI was accompanied by reductions in Mini-Mental Status Examination (MMSE) scores, global white matter network connectivity, and the right hippocampus (rHIP) nodal efficiency within that network (false discovery rate (FDR), p < 0.05). Our results suggest the presence of a genetic risk and MCI led to more severe pathological symptoms and could be informative in the implementation of clinical trials for early stages of AD.
authors: State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, No. 19 Xinjiekouwai Street, Beijing, 100875, China.|BABRI Centre, Beijing Normal University, Beijing, 100875, People's Republic of China.
authors: Chao
authors: C
authors: Ma
authors: State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, No. 19 Xinjiekouwai Street, Beijing, 100875, China.|BABRI Centre, Beijing Normal University, Beijing, 100875, People's Republic of China.
authors: Jun
authors: J
authors: Wang
authors: State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, No. 19 Xinjiekouwai Street, Beijing, 100875, China.|BABRI Centre, Beijing Normal University, Beijing, 100875, People's Republic of China.
authors: Junying
authors: J
authors: Zhang
authors: BABRI Centre, Beijing Normal University, Beijing, 100875, People's Republic of China.|Banner Alzheimer's Institute, Phoenix, AZ, 85006, USA.
authors: Kewei
authors: K
authors: Chen
authors: State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, No. 19 Xinjiekouwai Street, Beijing, 100875, China.|BABRI Centre, Beijing Normal University, Beijing, 100875, People's Republic of China.
authors: Xin
authors: X
authors: Li
authors: State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, No. 19 Xinjiekouwai Street, Beijing, 100875, China.|BABRI Centre, Beijing Normal University, Beijing, 100875, People's Republic of China.
authors: Ni
authors: N
authors: Shu
authors: State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, No. 19 Xinjiekouwai Street, Beijing, 100875, China.|BABRI Centre, Beijing Normal University, Beijing, 100875, People's Republic of China.
authors: Yaojing
authors: Y
authors: Chen
authors: State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, No. 19 Xinjiekouwai Street, Beijing, 100875, China.|BABRI Centre, Beijing Normal University, Beijing, 100875, People's Republic of China.
authors: Zhen
authors: Z
authors: Liu
authors: State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, No. 19 Xinjiekouwai Street, Beijing, 100875, China. zhang_rzs@bnu.edu.cn.|BABRI Centre, Beijing Normal University, Beijing, 100875, People's Republic of China. zhang_rzs@bnu.edu.cn.
authors: Zhanjun
authors: Z
authors: Zhang
mesh_terms: D000368:Aged; D053327:Apolipoprotein E4 / Q000235:genetics*; D001921:Brain / Q000473:pathology* / Q000503:physiopathology*; D060825:Cognitive Dysfunction / Q000235:genetics* / Q000473:pathology*; D005260:Female; D006624:Hippocampus / Q000473:pathology; D006801:Humans; D008297:Male; D009415:Nerve Net / Q000473:pathology* / Q000503:physiopathology*; D009483:Neuropsychological Tests; D066127:White Matter / Q000473:pathology
chemical_list: D053327:Apolipoprotein E4
keywords: APOE ε4; Brain network; Hippocampus; Interaction; Mild cognitive impairment