title: SecA-a New Twist in the Tale.
abstract: A paper published in this issue of the Journal of Bacteriology (D. Huber, M. Jamshad, R. Hanmer, D. Schibich, K. Döring, I. Marcomini, G. Kramer, and B. Bukau, J Bacteriol 199:e0622-16, 2017, https://doi.org/10.1128/JB.00622-16) provides us with a timely reminder that all is not as clear as we had previously thought in the general bacterial secretion system. The paper describes a new mode of secretion through the Sec system-"uncoupled cotranslocation"-for the passage of proteins across the bacterial inner membrane and suggests that we might rethink the nature and mechanism of the targeting and transport steps toward protein export.
authors: School of Biochemistry, University of Bristol, Bristol, United Kingdom ian.collinson@bristol.ac.uk.
authors: Ian
authors: http://orcid.org/0000-0002-3931-0503
authors: I
authors: Collinson
mesh_terms: D000251:Adenosine Triphosphatases / Q000235:genetics / Q000378:metabolism*; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D058947:Bacterial Secretion Systems / Q000502:physiology*; D002462:Cell Membrane; D015964:Gene Expression Regulation, Bacterial / Q000502:physiology*; D021381:Protein Transport / Q000502:physiology; D000069816:SEC Translocation Channels / Q000235:genetics / Q000378:metabolism*; D000081416:SecA Proteins
chemical_list: D001426:Bacterial Proteins; D058947:Bacterial Secretion Systems; D000069816:SEC Translocation Channels; D000251:Adenosine Triphosphatases; D000081416:SecA Proteins
keywords: ATPase; SecY complex; bacterial secretion; protein targeting; protein translocation