title: Network Consistency Projection for Human miRNA-Disease Associations Inference.
abstract: Prediction and confirmation of the presence of disease-related miRNAs is beneficial to understand disease mechanisms at the miRNA level. However, the use of experimental verification to identify disease-related miRNAs is expensive and time-consuming. Effective computational approaches used to predict miRNA-disease associations are highly specific. In this study, we develop the Network Consistency Projection for miRNA-Disease Associations (NCPMDA) method to reveal the potential associations between miRNAs and diseases. NCPMDA is a non-parametric universal network-based method that can simultaneously predict miRNA-disease associations in all diseases but does not require negative samples. NCPMDA can also confirm the presence of miRNAs in isolated diseases (diseases without any known miRNA association). Leave-one-out cross validation and case studies have shown that the predictive performance of NCPMDA is superior over that of previous method.
authors: College of Information Science and Engineering, Hunan University, Changsha, Hunan 410082, China.
authors: Changlong
authors: C
authors: Gu
authors: College of Information Science and Engineering, Hunan University, Changsha, Hunan 410082, China.
authors: Bo
authors: B
authors: Liao
authors: College of Information Science and Engineering, Hunan University, Changsha, Hunan 410082, China.
authors: Xiaoying
authors: X
authors: Li
authors: Department of Computer Science, State University of New York, New Paltz, New York 12561, USA.
authors: Keqin
authors: K
authors: Li
mesh_terms: D000465:Algorithms; D001943:Breast Neoplasms / Q000235:genetics*; D006528:Carcinoma, Hepatocellular / Q000235:genetics*; D019295:Computational Biology / Q000379:methods; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics*; D035683:MicroRNAs / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics
chemical_list: D035683:MicroRNAs; D012333:RNA, Messenger