title: Glycated albumin is associated with body mass index in euglycemic adults but is not predictive of postprandial blood glucose response.
abstract: BACKGROUND
  The level of glycated albumin in circulation is an indicator of blood glucose control over the preceding 2 weeks. It is not known if the level of glycated albumin in circulation relates to an individual's postprandial blood glucose response.
  
  
  METHODS
  Eighty-four euglycemic young adults (21.1 [3.9] years, BMI 23.9 [4.0] kg/m2) primarily of European descent underwent a fasted meal test of 50 g carbohydrate from white bread. Capillary blood was then sampled at regular intervals over 2 hours. Correlations were sought between glycated albumin, fasted and 2-hour post-load blood glucose measurements, incremental area under the blood glucose curve, glycemic range, body mass index (BMI), and C-reactive protein (CRP).
  
  
  RESULTS
  When adjusted for age and sex, glycated albumin was inversely correlated with BMI (r=-.25, P=.027). No significant correlations existed for glycated albumin and postprandial markers of blood glucose control. BMI and CRP values correlate in this population (r=.30, P=.009).
  
  
  CONCLUSIONS
  Glycated albumin in circulation is not related to postprandial blood glucose response in young euglycemic adults. Glycated albumin is lower in euglycemic adults with higher BMI values. Contrary to research with older adults or those with impaired glucose control, glycated albumin did not correlate to CRP.
authors: Department of Human Nutrition, University of Otago, Dunedin, New Zealand.|Edgar National Centre for Diabetes and Obesity Research, Dunedin, New Zealand.
authors: Andrew N
authors: http://orcid.org/0000-0001-8952-3892
authors: AN
authors: Reynolds
authors: Department of Human Nutrition, University of Otago, Dunedin, New Zealand.
authors: Ashley
authors: A
authors: Duncan
authors: Department of Human Nutrition, University of Otago, Dunedin, New Zealand.|Edgar National Centre for Diabetes and Obesity Research, Dunedin, New Zealand.
authors: Devonia
authors: D
authors: Kruimer
authors: Department of Human Nutrition, University of Otago, Dunedin, New Zealand.
authors: Bernard J
authors: BJ
authors: Venn
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000032:analysis / Q000378:metabolism; D001786:Blood Glucose / Q000032:analysis / Q000378:metabolism*; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D005260:Female; D017127:Glycation End Products, Advanced; D006801:Humans; D008297:Male; D019518:Postprandial Period / Q000502:physiology*; D012709:Serum Albumin / Q000032:analysis / Q000378:metabolism*; D055815:Young Adult; D000093423:Glycated Serum Albumin
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D017127:Glycation End Products, Advanced; D012709:Serum Albumin; D000093423:Glycated Serum Albumin
keywords: biomarker; blood glucose control; body mass index; glycated plasma proteins; obesity