title: The Role of IL-37 in Non-Cancerous Diseases.
abstract: IL-37 is a newly discovered cytokine belonging to IL-1 family consisting of 11 members, which have similar β-barrel structures and associate with Ig-like receptors. Extensive studies have been done with IL-37 since its discovery. These studies suggest that IL-37 does not only play a role in tumorigenesis, but also has anti-inflammatory properties in immune responses through the down regulation of pro-inflammatory molecules. We have previously reviewed the role of IL-37 in cancer. Here, we will focus on the role of IL-37 in non-cancerous Diseases. Such a study might be helpful to design new strategies to treat IL-37 associated diseases.
authors: Department of Microbiology, Immunology & Pathology, Des Moines University College of Osteopathic Medicine, Des Moines, IA, 50312, USA.
authors: Vivi A
authors: VA
authors: Ding
authors: Department of Surgery, University of Missouri School of Medicine, Columbia, MO, 65212, USA.
authors: Ziwen
authors: Z
authors: Zhu
authors: Department of Microbiology, Immunology & Pathology, Des Moines University College of Osteopathic Medicine, Des Moines, IA, 50312, USA.
authors: Alyse A
authors: AA
authors: Mantz
authors: The Affiliated Hospital of Xiangnan University, Chenzhou, Hunan, China.
authors: Huaping
authors: H
authors: Xiao
authors: Department of Surgery, University of Missouri School of Medicine, Columbia, MO, 65212, USA.
authors: Mark R
authors: MR
authors: Wakefield
authors: Department of Surgery, University of Missouri School of Medicine, Columbia, MO, 65212, USA.
authors: Qian
authors: Q
authors: Bai
authors: Department of Microbiology, Immunology & Pathology, Des Moines University College of Osteopathic Medicine, Des Moines, IA, 50312, USA. yujiang.fang@dmu.edu.|Department of Surgery, University of Missouri School of Medicine, Columbia, MO, 65212, USA. yujiang.fang@dmu.edu.
authors: Yujiang
authors: Y
authors: Fang
mesh_terms: D000818:Animals; D063646:Carcinogenesis / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D007375:Interleukin-1 / Q000378:metabolism*; D009369:Neoplasms / Q000378:metabolism*
chemical_list: D007375:Interleukin-1
keywords: IL-37; Non-cancerous diseases