title: CrIII-Substituted Heteropoly-16-Tungstates [CrIII2(B-β-XIVW8O31)2]14-(X = Si, Ge): Magnetic, Biological, and Electrochemical Studies.
abstract: The dichromium(III)-containing heteropoly-16-tungstates [CrIII2(B-β-SiIVW8O31)2]14-(1) and [CrIII2(B-β-GeIVW8O31)2]14-(2) were prepared via a one-pot reaction of the composing elements in aqueous, basic medium. Polyanions 1 and 2 represent the first examples of CrIII-containing heteropolytungstates comprising the octatungstate unit {XW8O31} (X = Si, Ge). Magnetic studies demonstrated that, in the solid state, the two polyanions exhibit a weak antiferromagnetic interaction between the two CrIIIcenters with J = -3.5 ± 0.5 cm-1, with no long-range ordering down to 1.8 K. The ground-state spin of polyanions 1 and 2 was thus deduced to be 0, but the detection of a complex set of EPR signals implies that there are thermally accessible excited states containing unpaired spins resulting from the two S =3/2CrIIIions. A comprehensive electrochemistry study on 1 and 2 in solution was performed, and biological tests showed that both polyanions display significant antidiabetic and anticancer activities.
authors: Jacobs University , Department of Life Sciences and Chemistry, P.O. Box 750561, 28725 Bremen, Germany.
authors: Wenjing
authors: W
authors: Liu
authors: Jacobs University , Department of Life Sciences and Chemistry, P.O. Box 750561, 28725 Bremen, Germany.
authors: Rami
authors: R
authors: Al-Oweini
authors: Jacobs University , Department of Life Sciences and Chemistry, P.O. Box 750561, 28725 Bremen, Germany.
authors: Karen
authors: K
authors: Meadows
authors: Jacobs University , Department of Life Sciences and Chemistry, P.O. Box 750561, 28725 Bremen, Germany.|Department of Chemistry, Faculty of Sciences, University of Balamand , P.O. Box 100, Tripoli, Lebanon.
authors: Bassem S
authors: BS
authors: Bassil
authors: Jacobs University , Department of Life Sciences and Chemistry, P.O. Box 750561, 28725 Bremen, Germany.
authors: Zhengguo
authors: Z
authors: Lin
authors: Department of Chemistry and Biochemistry, Florida State University , 95 Chieftan Way, Tallahassee, Florida 32306, United States.
authors: Jonathan H
authors: JH
authors: Christian
authors: Department of Chemistry and Biochemistry, Florida State University , 95 Chieftan Way, Tallahassee, Florida 32306, United States.
authors: Naresh S
authors: NS
authors: Dalal
authors: Laboratoire de Chimie-Physique, UMR8000 CNRS, Université Paris-Sud , Orsay F-91405, France.|Université Félix Houphouët-Boigny , 01 BP V34 Abidjan 01, Ivory Coast.
authors: A Martin
authors: AM
authors: Bossoh
authors: Laboratoire de Chimie-Physique, UMR8000 CNRS, Université Paris-Sud , Orsay F-91405, France.
authors: Israël M
authors: IM
authors: Mbomekallé
authors: Laboratoire de Chimie-Physique, UMR8000 CNRS, Université Paris-Sud , Orsay F-91405, France.
authors: Pedro
authors: P
authors: de Oliveira
authors: Center for Advanced Drug Research, COMSATS Institute of Information Technology , Abbottabad 22060, Pakistan.
authors: Jamshed
authors: J
authors: Iqbal
authors: Jacobs University , Department of Life Sciences and Chemistry, P.O. Box 750561, 28725 Bremen, Germany.
authors: Ulrich
authors: U
authors: Kortz
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002522:Chlorocebus aethiops; D002857:Chromium / Q000737:chemistry* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D003920:Diabetes Mellitus / Q000188:drug therapy; D055664:Electrochemical Techniques; D004578:Electron Spin Resonance Spectroscopy; D005959:Glucosidases / Q000037:antagonists & inhibitors; D006801:Humans; D007004:Hypoglycemic Agents / Q000737:chemistry* / Q000494:pharmacology; D008958:Models, Molecular; D009369:Neoplasms / Q000188:drug therapy; D017973:Tungsten Compounds / Q000737:chemistry* / Q000494:pharmacology; D014709:Vero Cells
chemical_list: D000970:Antineoplastic Agents; D007004:Hypoglycemic Agents; D017973:Tungsten Compounds; D002857:Chromium; D005959:Glucosidases; C045951:tungstate