title: Comprehensive Characterization of Cellular Immune Responses Following Ebola Virus Infection.
abstract: The West African Ebola virus disease (EVD) outbreak was the largest EVD outbreak in history. However, data on lymphocyte dynamics and the antigen specificity of T cells in Ebola survivors are scarce, and our understanding of EVD pathophysiology is limited. A case of EVD survival in which the patient cleared Ebola virus (EBOV) infection without experimental drugs allowed for the detailed examination of lymphocyte dynamics. We demonstrate the persistence of T-cell activation well beyond viral clearance and detect EBOV-specific T cells. Our study provides significant insights into lymphocyte specificity during the recovery phase of EVD and may inform novel strategies to treat EVD.
authors: 1st Department of Medicine, University Medical Center Hamburg-Eppendorf.|German Center for Infection Research (DZIF), partner site Hamburg-Lübeck-Borstel-Riems.
authors: Christine
authors: C
authors: Dahlke
authors: Leibniz Institute for Experimental Virology, Heinrich-Pette-Institute,Hamburg.
authors: Sebastian
authors: S
authors: Lunemann
authors: 1st Department of Medicine, University Medical Center Hamburg-Eppendorf.|German Center for Infection Research (DZIF), partner site Hamburg-Lübeck-Borstel-Riems.
authors: Rahel
authors: R
authors: Kasonta
authors: 1st Department of Medicine, University Medical Center Hamburg-Eppendorf.
authors: Benno
authors: B
authors: Kreuels
authors: 1st Department of Medicine, University Medical Center Hamburg-Eppendorf.
authors: Stefan
authors: S
authors: Schmiedel
authors: 1st Department of Medicine, University Medical Center Hamburg-Eppendorf.|German Center for Infection Research (DZIF), partner site Hamburg-Lübeck-Borstel-Riems.
authors: My L
authors: ML
authors: Ly
authors: German Center for Infection Research (DZIF), partner site Giessen-Marburg-Langen, Braunschweig.|Institute for Virology, Philipps University Marburg, Germany.
authors: Sarah K
authors: SK
authors: Fehling
authors: German Center for Infection Research (DZIF), partner site Giessen-Marburg-Langen, Braunschweig.|Institute for Virology, Philipps University Marburg, Germany.
authors: Thomas
authors: T
authors: Strecker
authors: German Center for Infection Research (DZIF), partner site Giessen-Marburg-Langen, Braunschweig.|Institute for Virology, Philipps University Marburg, Germany.
authors: Stephan
authors: S
authors: Becker
authors: Leibniz Institute for Experimental Virology, Heinrich-Pette-Institute, Hamburg.|German Center for Infection Research (DZIF), partner site Hamburg-Lübeck-Borstel-Riems.
authors: Marcus
authors: M
authors: Altfeld
authors: West African Health Organisation, Bobo-Dioulasso, Burkina Faso.
authors: Abdourahmane
authors: A
authors: Sow
authors: 1st Department of Medicine, University Medical Center Hamburg-Eppendorf.|German Center for Infection Research (DZIF), partner site Hamburg-Lübeck-Borstel-Riems.
authors: Ansgar W
authors: AW
authors: Lohse
authors: Leibniz Institute for Experimental Virology, Heinrich-Pette-Institute,Hamburg.
authors: César
authors: C
authors: Muñoz-Fontela
authors: 1st Department of Medicine, University Medical Center Hamburg-Eppendorf.|German Center for Infection Research (DZIF), partner site Hamburg-Lübeck-Borstel-Riems.
authors: Marylyn M
authors: MM
authors: Addo
mesh_terms: D029043:Ebolavirus / Q000276:immunology*; D019142:Hemorrhagic Fever, Ebola / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D008213:Lymphocyte Activation; D013601:T-Lymphocytes / Q000276:immunology
keywords: EVD; EVD survivor; Ebola GP–specific T-cell responses; T-cell activation; cellular immune response; convalescent phase; lymphocyte dynamics; polyfunctional T-cell responses