title: Ruthenium-Catalyzed C-H Arylation of Benzoic Acids and Indole Carboxylic Acids with Aryl Halides.
abstract: Herein we report the first Ru-catalyzed C-H arylation of benzoic acids with readily available aryl (pseudo)halides. The reaction, which does not require the use of silver salt additives, allows the arylation of previously challenging hindered benzoic acids and the use of generally unreactive ortho-substituted halorarenes. Furthermore, our new protocol can efficiently be applied to indole carboxylic acids, thus allowing access to C7-, C6-, C5- and C4-arylated indole compounds, a departure from the classical enhanced reactivity of the C2 and C3 positions of indole.
authors: School of Chemistry, University of Manchester, Oxford Road, Manchester, M13 9PL, UK.
authors: Marco
authors: M
authors: Simonetti
authors: School of Chemistry, University of Manchester, Oxford Road, Manchester, M13 9PL, UK.
authors: Diego M
authors: DM
authors: Cannas
authors: School of Chemistry, University of Manchester, Oxford Road, Manchester, M13 9PL, UK.
authors: Adyasha
authors: A
authors: Panigrahi
authors: School of Chemistry, University of Manchester, Oxford Road, Manchester, M13 9PL, UK.
authors: Szymon
authors: S
authors: Kujawa
authors: Department of Inorganic and Analytical Chemistry, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780, Poznan, Poland.
authors: Michal
authors: M
authors: Kryjewski
authors: School of Chemistry, University of Manchester, Oxford Road, Manchester, M13 9PL, UK.
authors: Pan
authors: P
authors: Xie
authors: School of Chemistry, University of Manchester, Oxford Road, Manchester, M13 9PL, UK.
authors: Igor
authors: 0000-0002-5391-7424
authors: I
authors: Larrosa
keywords: C−H activation; arylation; benzoic acids; indole carboxylic acids; ruthenium