title: A Case ofDe NovoCD5+ Disseminated Intravascular Large B-Cell Lymphoma Presenting as Multiorgan Failure.
abstract: Intravascular large B-cell lymphoma is an extremely rare extranodal lymphoma that proliferates in the lumen of the blood vessels while sparing the organ parenchyma. It usually presents with CNS and skin involvement. A 65-year-old Caucasian female presented with fevers and chills of 3-4 months' duration. Bone marrow biopsy done 3 months prior showed no significant myelodysplasia or lymphoid aggregates. The patient later died due to multiorgan failure. A bone marrow biopsy showed 20-30% CD5+ B cells consistent with infiltrative large B-cell lymphoma. An autopsy performed revealed diffuse intravascular invasion by lymphoma cells. Multiorgan involvement by intravascular B-cell lymphoma is very rare. Based on our literature review and to the best of our knowledge, there are only 5 case reports describing the presentation of this lymphoma with multiorgan failure. The immunophenotypic studies performed revealed that our patient hadde novoCD5+ intravascular large B-cell lymphoma which is known to be aggressive with very poor prognosis. Although it is an extremely rare lymphoma, it should be considered as a potential cause of multiorgan failure when no other cause has been identified. A prompt tissue diagnosis and high-dose chemotherapy followed by ASCT can sometimes achieve remission.
authors: Department of Internal Medicine, The University of Missouri Kansas City School of Medicine, 2301 Holmes Street, Kansas City, MO 64108, USA.
authors: Daulath
authors: 0000-0002-0346-8501
authors: D
authors: Singh
authors: Department of Internal Medicine, The University of Missouri Kansas City School of Medicine, 2301 Holmes Street, Kansas City, MO 64108, USA.
authors: Devika
authors: D
authors: Kapuria
authors: Department of Laboratory Medicine, Saint Luke's Hospital of Kansas City, 4401 Wornall Road, Kansas City, MO 64111, USA.
authors: Suparna
authors: S
authors: Nanua
authors: Department of Hematology/Oncology, Saint Luke's Hospital of Kansas City, Saint Luke's Cancer Specialists, 4321 Washington Street, No. 4000, Kansas City, MO 64111, USA.
authors: Rakesh
authors: R
authors: Gaur