title: Treatment of cadmium-induced renal oxidative damage in rats by administration of alpha-lipoic acid.
abstract: Cadmium (Cd) is a toxic heavy metal that is widespread and nephrotoxic, but the mechanism of its toxicity is not well understood. Alpha-lipoic acid (α-LA) has a protective effect on Cd-induced oxidative stress, but the underlying mechanism is also not clear. This study aimed to confirm that Cd causes renal damage and to explore the potential underlying mechanism of α-LA to the kidney. Rats were randomly divided into four groups: control group, Cd group (50 mg/L CdAc2), Cd+α-LA group (50 mg/L CdAc2+ 50 mg/kg body wt/day α-LA), and α-LA group (50 mg/kg body wt/day). The rats were exposed to Cd via drinking water and α-LA in the form of gavage at the same time every day. After 12 weeks, the activity of antioxidant enzymes and the level of Cd in the kidney were analyzed. Renal damage was evaluated based on histopathological and ultrastructure examinations. The apoptosis index was determined based on the results of western blotting and qRT-PCR. Our results indicate that accumulation of Cd causes serious kidney damage and α-LA has a protective effect against Cd-induced oxidative stress and apoptosis. Further, the findings indicate that the antioxidant, Cd chelation, and antiapoptotic activities of α-LA are the key factors that alleviate nephrotoxicity.
authors: College of Veterinary Medicine, Jiangsu Key Laboratory of Zoonosis, Yangzhou University, Yangzhou, Jiangsu, 225009, China.|Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu, 225009, China.
authors: Tongwang
authors: T
authors: Luo
authors: College of Veterinary Medicine, Jiangsu Key Laboratory of Zoonosis, Yangzhou University, Yangzhou, Jiangsu, 225009, China.|Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu, 225009, China.
authors: Gang
authors: G
authors: Liu
authors: College of Veterinary Medicine, Jiangsu Key Laboratory of Zoonosis, Yangzhou University, Yangzhou, Jiangsu, 225009, China.|Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu, 225009, China.
authors: Mengfei
authors: M
authors: Long
authors: College of Veterinary Medicine, Jiangsu Key Laboratory of Zoonosis, Yangzhou University, Yangzhou, Jiangsu, 225009, China.|Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu, 225009, China.
authors: Jinlong
authors: J
authors: Yang
authors: College of Veterinary Medicine, Jiangsu Key Laboratory of Zoonosis, Yangzhou University, Yangzhou, Jiangsu, 225009, China.|Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu, 225009, China.
authors: Ruilong
authors: R
authors: Song
authors: College of Veterinary Medicine, Jiangsu Key Laboratory of Zoonosis, Yangzhou University, Yangzhou, Jiangsu, 225009, China.|Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu, 225009, China.
authors: Yi
authors: Y
authors: Wang
authors: College of Veterinary Medicine, Jiangsu Key Laboratory of Zoonosis, Yangzhou University, Yangzhou, Jiangsu, 225009, China.|Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu, 225009, China.
authors: Yan
authors: Y
authors: Yuan
authors: College of Veterinary Medicine, Jiangsu Key Laboratory of Zoonosis, Yangzhou University, Yangzhou, Jiangsu, 225009, China.|Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu, 225009, China.
authors: Jianchun
authors: J
authors: Bian
authors: College of Veterinary Medicine, Jiangsu Key Laboratory of Zoonosis, Yangzhou University, Yangzhou, Jiangsu, 225009, China.|Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu, 225009, China.
authors: Xuezhong
authors: X
authors: Liu
authors: College of Veterinary Medicine, Jiangsu Key Laboratory of Zoonosis, Yangzhou University, Yangzhou, Jiangsu, 225009, China.|Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu, 225009, China.
authors: Jianhong
authors: J
authors: Gu
authors: College of Veterinary Medicine, Jiangsu Key Laboratory of Zoonosis, Yangzhou University, Yangzhou, Jiangsu, 225009, China.|Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu, 225009, China.
authors: Hui
authors: H
authors: Zou
authors: College of Veterinary Medicine, Jiangsu Key Laboratory of Zoonosis, Yangzhou University, Yangzhou, Jiangsu, 225009, China. liuzongping@yzu.edu.cn.|Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu, 225009, China. liuzongping@yzu.edu.cn.
authors: Zongping
authors: Z
authors: Liu
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D017209:Apoptosis / Q000187:drug effects; D002104:Cadmium / Q000633:toxicity*; D005260:Female; D007668:Kidney / Q000187:drug effects*; D007674:Kidney Diseases / Q000139:chemically induced / Q000188:drug therapy*; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D008063:Thioctic Acid / Q000627:therapeutic use*
chemical_list: D000975:Antioxidants; D002104:Cadmium; D008063:Thioctic Acid
keywords: Apoptosis; Cadmium; Oxidative damage; Protective effect; α-Lipoic acid