title: Fowler's Solution and the Evolution of the Use of Arsenic in Modern Medicine.
abstract: While arsenic has been used medicinally and as a poison for thousands of years, Fowler's solution, an arsenic compound, has had a fascinating history in medicine during the past 200 years. The use of Fowler's solution was first described and published as a treatment for malaria and syphilis in the late 1700s. Many clinical applications for Fowler's solutions have been studied and utilized over the years, but toxicities have limited its utility. Even so, arsenic trioxide, chemically related to Fowler's solution, was approved by the US Food and Drug Administration for treating acute promyelocytic leukemia. The history of Fowler's solution, its applications and uses, and benefits and risks are discussed.
authors: Department of Dermatology, SUNY Health Science Center, Brooklyn, NY.
authors: Derek
authors: D
authors: Ho
authors: Department of Dermatology, SUNY Health Science Center, Brooklyn, NY.|Brookdale University Hospital, Brooklyn, NY; evlow13@yahoo.com.
authors: Eve J
authors: EJ
authors: Lowenstein
mesh_terms: D000077237:Arsenic Trioxide; D001152:Arsenicals / Q000266:history / Q000627:therapeutic use*; D018053:Arsenites / Q000266:history / Q000506:poisoning / Q000627:therapeutic use; D049671:History, 18th Century; D049672:History, 19th Century; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000188:drug therapy; D008288:Malaria / Q000188:drug therapy / Q000266:history; D010087:Oxides / Q000266:history / Q000506:poisoning / Q000627:therapeutic use*; D017680:Potassium Compounds / Q000266:history / Q000506:poisoning / Q000627:therapeutic use; D013587:Syphilis / Q000188:drug therapy / Q000266:history; D014481:United States
chemical_list: D001152:Arsenicals; D018053:Arsenites; D010087:Oxides; D017680:Potassium Compounds; C009003:potassium arsenite solution; D000077237:Arsenic Trioxide