title: Fornix-Based Versus Limbal-Based Conjunctival Trabeculectomy Flaps for Glaucoma: Findings From a Cochrane Systematic Review.
abstract: OBJECTIVE
  To compare effectiveness of fornix- and limbal-based conjunctival flaps in trabeculectomy surgery.
  
  
  METHODS
  Systematic review.
  
  
  METHODS
  Setting: CENTRAL, MEDLINE, LILACS, ISRCTN registry, ClinicalTrials.gov, WHO, and ICTRP were searched to identify eligible randomized controlled trials (RCTs).
  
  
  METHODS
  RCTs in which benefits and complications of fornix- vs limbal-based trabeculectomy for glaucoma were compared in adult glaucoma patients.
  
  
  METHODS
  We followed Cochrane methodology for data extraction.
  
  
  METHODS
  Proportion of failed trabeculectomies at 24 months, defined as the need for repeat surgery or uncontrolled intraocular pressure (IOP) >22 mm Hg, despite topical/systemic medications.
  
  
  RESULTS
  The review included 6 trials with a total of 361 participants, showing no difference in effectiveness between fornix-based vs limbal-based trabeculectomy surgery, although with a high level of uncertainty owing to low event rates. In the fornix-based and limbal-based surgery, mean IOP at 12 months was similar, with ranges of 12.5-15.5 mm Hg and 11.7-15.1 mm Hg, respectively. Mean difference was 0.44 mm Hg (95% CI -0.45 to 1.33) and 0.86 mm Hg (95% CI -0.52 to 2.24) at 12 and 24 months of follow-up, respectively. Mean number of postoperative glaucoma medications was similar between the 2 groups. Mean difference was 0.02 (95% CI -0.15 to 0.19) at 12 months. As far as postoperative complications, an increased risk of shallow anterior chamber was observed in the limbal-based group.
  
  
  CONCLUSIONS
  Similar efficacy of trabeculectomy surgery with respect to bleb failure or IOP control was observed in both types of conjunctival flap incisions. A significant difference was detected in the risk of postoperative shallow anterior chamber, which was increased in the limbal-based group.
authors: Department of Ophthalmology, American University of Beirut, Beirut, Lebanon. Electronic address: ca12@aub.edu.lb.
authors: Christiane E
authors: CE
authors: Al-Haddad
authors: Department of Ophthalmology, American University of Beirut, Beirut, Lebanon.
authors: Marwan
authors: M
authors: Abdulaal
authors: Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts.
authors: Ahmad
authors: A
authors: Al-Moujahed
authors: Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
authors: Ann-Margret
authors: AM
authors: Ervin
authors: Department of Ophthalmology, American University of Beirut, Beirut, Lebanon.
authors: Karine
authors: K
authors: Ismail
mesh_terms: D003228:Conjunctiva / Q000601:surgery*; D005901:Glaucoma / Q000601:surgery*; D006801:Humans; D016850:Limbus Corneae / Q000601:surgery*; D013524:Surgical Flaps; D014130:Trabeculectomy / Q000379:methods*