title: Dragmacidins G and H, Bisindole Alkaloids Tethered by a Guanidino Ethylthiopyrazine Moiety, from a Lipastrotethya sp. Marine Sponge.
abstract: LCMS analysis of the extract and a cytotoxicity assay of the HPLC fractions generated from a small-scale extract of a Lipastrotethya sp. marine sponge demonstrated the presence of bisindole alkaloids that were associated with the cytotoxic activity. Two bisindole alkaloids tethered by a guanidino ethylthiopyrazine moiety, dragmacidins G (1) and H (2), were isolated, and their structures were assigned by analysis of the MS and NMR data. They showed moderate cytotoxic activity against HeLa cells.
authors: Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, Graduate School of Science, The University of Tokyo , Bunkyo-ku, Tokyo, 113-8657, Japan.
authors: Yuki
authors: Y
authors: Hitora
authors: Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, Graduate School of Science, The University of Tokyo , Bunkyo-ku, Tokyo, 113-8657, Japan.
authors: Kentaro
authors: K
authors: Takada
authors: Sugashima Marine Biological Laboratory, Graduate School of Science, Nagoya University , Toba, Mie 517-0004, Japan.
authors: Yuji
authors: Y
authors: Ise
authors: Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, Graduate School of Science, The University of Tokyo , Bunkyo-ku, Tokyo, 113-8657, Japan.
authors: Shigeru
authors: S
authors: Okada
authors: Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, Graduate School of Science, The University of Tokyo , Bunkyo-ku, Tokyo, 113-8657, Japan.
authors: Shigeki
authors: S
authors: Matsunaga
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008386:Marine Biology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D026121:Indole Alkaloids; C000620039:dragmacidin G; C000620040:dragmacidin H