title: Total variation-based method for generation of intravoxel incoherent motion parametric images in MRI.
abstract: Total variation (TV) method has been used widely for image restoration and reconstruction. In this work, we propose a TV-based algorithm for parametric image generation in intravoxel incoherent motion (IVIM) diffusion-weighted magnetic resonance imaging (DW-MRI).
  
  
  
  We used simulated and real data to investigate whether the proposed TV-based method can provide reliable parametric images. Parametric images of IVIM parameters including perfusion fraction (PF), diffusion coefficient (D), and pseudo-diffusion coefficient (D*) were estimated using DW-MRI data and TV through fitting the IVIM model. The Levenberg-Marquardt (LM) method, which has often been used in the context of IVIM analysis, was employed as the standard method for comparison of the resulting parametric images.
  
  
  
  The simulation results show that the proposed method outperforms the LM algorithm in terms of precision, providing a 40-81%, 90-93%, and 68-84% improvement for PF, D and D*, respectively, at signal-to-noise ratio (SNR) of 30. For real data, the proposed method showed an average five-fold, three-fold, and four-fold improvement in the SNR for PF, D and D*, respectively.
  
  
  
  We introduced the use of TV to produce parametric images, and demonstrated that the proposed TV-based method is effective in improving the parametric image quality. Magn Reson Med 78:1383-1391, 2017. © 2016 International Society for Magnetic Resonance in Medicine.
authors: Department of Nuclear Medicine and Center for Advanced Molecular Imaging and Translation, Chang Gung Memorial Hospital, No. 5 Fu-Shin Street, Kwei-Shan, Taoyuan County, Taiwan.
authors: Chieh
authors: C
authors: Lin
authors: Siemens Shenzhen Magnetic Resonance Ltd. Siemens MR Center, Gaoxin C. Ave., 2nd, Hi-Tech Industrial Park, Shenzhen, 518057, P.R. China.
authors: Yi-Yu
authors: YY
authors: Shih
authors: Department of Medical Imaging and Radiological Sciences, Chang Gung University, 259 Wen-Hwa 1st Road, Kwei-Shan, Taoyuan County, Taiwan.
authors: Siao-Lan
authors: SL
authors: Huang
authors: Department of Nuclear Medicine and Center for Advanced Molecular Imaging and Translation, Chang Gung Memorial Hospital, No. 5 Fu-Shin Street, Kwei-Shan, Taoyuan County, Taiwan.|Medical Physics Research Center, Institute of Radiological Research, Chang Gung University and Chang Gung Memorial Hospital, 259 Wen-Hwa 1st Road, Kwei-Shan, Taoyuan County, Taiwan.
authors: Hsuan-Ming
authors: HM
authors: Huang
mesh_terms: D000465:Algorithms; D003198:Computer Simulation; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008875:Middle Aged; D059629:Signal-To-Noise Ratio
keywords: diffusion-weighted imaging; intravoxel incoherent motion; total variation