title: Feather keratin hydrogel for wound repair: Preparation, healing effect and biocompatibility evaluation.
abstract: Keratins are highly attractive for wound healing due to their inherent bioactivity, biocompatibility and physical properties. However, nearly all wound healing studies have focused on human hair keratins, and the wound-repair effects and in vivo biocompatibilities of feather keratins are not clear. Feather keratins are derived from chicken feathers, which are considered to be the major waste in the poultry industry, and the quality of feather keratin is easier to control than that of human hair keratin due to human hair perming and colouring-dyeing. Thus, we extracted keratins from chicken feathers, and a feather keratin hydrogel was then prepared and used to test the in vivo wound-healing properties and biocompatibility. The results indicated that feather keratins displayed wound-healing and biodegradation properties similar to those of human hair keratins and were also highly compatible with those of the tissue and devoid of immunogenicity and systematic toxicity. Collectively, these results suggested that feather keratin hydrogel could be used for biomedical applications, particularly effective wound healing.
authors: Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400030, China.
authors: Ju
authors: J
authors: Wang
authors: Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400030, China. Electronic address: shilei_hao@cqu.edu.cn.
authors: Shilei
authors: S
authors: Hao
authors: Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400030, China.
authors: Tiantian
authors: T
authors: Luo
authors: Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400030, China; Faculty of Pharmacy, College of Chemistry and Chemical Engineering, Chongqing University, Chongqing 400030, China.
authors: Zhongjun
authors: Z
authors: Cheng
authors: Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400030, China.
authors: Wenfeng
authors: W
authors: Li
authors: Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400030, China.
authors: Feiyan
authors: F
authors: Gao
authors: Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400030, China.
authors: Tingwang
authors: T
authors: Guo
authors: Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400030, China.
authors: Yuhua
authors: Y
authors: Gong
authors: Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400030, China. Electronic address: wangbc2000@126.com.
authors: Bochu
authors: B
authors: Wang
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000302:isolation & purification / Q000494:pharmacology*; D002645:Chickens; D005241:Feathers / Q000737:chemistry*; D005612:Freeze Drying; D015870:Gene Expression / Q000187:drug effects; D006801:Humans; D020100:Hydrogels / Q000737:chemistry / Q000494:pharmacology*; D020007:Implants, Experimental; D053583:Interleukin-1beta / Q000235:genetics / Q000276:immunology; D007633:Keratins / Q000302:isolation & purification / Q000494:pharmacology; D008297:Male; D016062:Porosity; D051381:Rats; D017207:Rats, Sprague-Dawley; D012212:Rheology; D012867:Skin / Q000187:drug effects / Q000276:immunology / Q000293:injuries; D054457:Tissue Scaffolds; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics / Q000276:immunology; D014945:Wound Healing / Q000187:drug effects* / Q000276:immunology
chemical_list: D001672:Biocompatible Materials; D020100:Hydrogels; C000594089:IL1B protein, rat; D053583:Interleukin-1beta; D014409:Tumor Necrosis Factor-alpha; D007633:Keratins
keywords: Biocompatibility; Feather keratin; Hydrogel; Wound healing