title: Three New Cytotoxic Polyhydroxysteroidal Glycosides from Starfish Craspidaster hesperus.
abstract: Three new polyhydroxysteroidal glycosides, hesperuside A (1), B (2), and C (3), as well as a known novaeguinoside A (4), were isolated from the ethanol extract of starfishCraspidaster hesperuscollected from the South China Sea. Their structures were elucidated by extensive spectroscopic methods and chemical evidence. The compounds1-3present unprecedented carbohydrate chain 3-O-methyl-β-d-galactopyranose, which differ from each other in the side chains. These compounds exhibited cytotoxicity against human tumor cells BEL-7402, MOLT-4, and A-549 in vitro.
authors: School of Medicine, Tongji University, 1239 Siping Road, Shanghai 200092, China. jkang@lear.com.|College of Food Science and Technology, Shanghai Ocean University, 999 Huchenghuan Road, Shanghai 201306, China. jkang@lear.com.
authors: Jun-Xia
authors: JX
authors: Kang
authors: College of Food Science and Technology, Shanghai Ocean University, 999 Huchenghuan Road, Shanghai 201306, China. yfkang@shou.edu.cn.
authors: Yong-Feng
authors: YF
authors: Kang
authors: School of Medicine, Tongji University, 1239 Siping Road, Shanghai 200092, China. hanhua@tongji.edu.cn.|Ocean College, Zhejiang University, 1 Zheda Road, Zhoushan 316021, China. hanhua@tongji.edu.cn.
authors: Hua
authors: H
authors: Han
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006027:Glycosides / Q000737:chemistry; D006801:Humans; D012503:Saponins / Q000737:chemistry* / Q000494:pharmacology*; D013215:Starfish / Q000737:chemistry*; D014020:Tissue Extracts / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D006027:Glycosides; D012503:Saponins; D014020:Tissue Extracts; C000619051:hesperuside A; C000619071:hesperuside B; C000619072:hesperuside C
keywords: cytotoxicity; polyhydroxysteroidal glycoside; starfish Craspidaster hesperus; tumor