title: 6-mo aerobic exercise intervention enhances the lipid peroxide transport function of HDL.
abstract: During acute exercise, the concentration of oxidized high-density lipoprotein (HDL) lipids (ox-HDL) is reported to increase suggesting that HDL may function in decreasing the concentration of oxidized low-density lipoprotein (LDL) lipids. However, the effect of exercise intervention on the lipid peroxide transport function of HDL is unknown. A randomized controlled trial with sedentary women (N = 161), aged 43-63, with no current use of hormone therapy, were randomized into a 6-month (mo) exercise group and a control group. During the 6-mo intervention, the concentration of ox-HDL increased in the exercise group by 5% and decreased in the control group by 2% (p = .003). Also, the ratio of ox-HDL to HDL-cholesterol increased by 5% in the exercise group and decreased by 1.5% in the control group (p = .036). The concentrations of cholesteryl ester transfer protein (CETP) and adiponectin did not change during the intervention. The concentration of serum triglycerides trended to decrease by 6% in the intervention group (p = .051). We found that the concentration of ox-HDL increased during the 6-mo aerobic exercise intervention, but the increase was not related to changes in the levels of CETP or adiponectin. These results, together with earlier studies, suggest that HDL has an active role in the reverse transport of lipid peroxides.
authors: a Sports Institute of Finland , Vierumäki , Finland.|b Department of Health and Exercise and Paavo Nurmi Center , University of Turku , Turku , Finland.
authors: Sanna
authors: S
authors: Tiainen
authors: c The UKK Institute for Health Promotion Research , Tampere , Finland.
authors: Riitta
authors: R
authors: Luoto
authors: d MCA Research Laboratory , Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku , Turku , Finland.
authors: Markku
authors: M
authors: Ahotupa
authors: c The UKK Institute for Health Promotion Research , Tampere , Finland.|e School of Health Sciences , University of Tampere , Finland.
authors: Jani
authors: J
authors: Raitanen
authors: c The UKK Institute for Health Promotion Research , Tampere , Finland.
authors: Tommi
authors: T
authors: Vasankari
mesh_terms: D000328:Adult; D015444:Exercise; D005260:Female; D006801:Humans; D008054:Lipid Peroxides / Q000378:metabolism*; D008075:Lipoproteins, HDL / Q000378:metabolism*; D008875:Middle Aged; D013997:Time Factors
chemical_list: D008054:Lipid Peroxides; D008075:Lipoproteins, HDL
keywords: Adiponectin; exercise; oxidized HDL; oxidized LDL; serum lipids