title: Effect of the Aged Garlic Extract on Cardiovascular Function in Metabolic Syndrome Rats.
abstract: The antioxidant properties of aged garlic extract (AGE) on cardiovascular functioning (CF) in metabolic syndrome (MS) remains poorly studied. Here we study the AGE effects on CF in a rat model of MS. Control rats plus saline solution (C + SS), MS rats (30% sucrose in drinking water from weaning) plus saline solution (MS + SS), control rats receiving AGE (C + AGE 125 mg/Kg/12 h) and MS rats with AGE (MS + AGE) were studied. MS + SS had increased triglycerides, systolic blood pressure, insulin, leptin, HOMA index, and advanced glycation end products. AGE returned their levels to control values (p< 0.01). Cholesterol was decreased by AGE (p= 0.05). Glutathion and GPx activity were reduced in MS + SS rats and increased with AGE (p= 0.05). Lipid peroxidation was increased in MS + SS and AGE reduced it (p= 0.001). Vascular functioning was deteriorated by MS (increased vasocontraction and reduced vasodilation) and AGE improved it (p= 0.001). Coronary vascular resistance was increased in MS rats and AGE decreased it (p= 0.001). Cardiac performance was not modified by MS but AGE increased it. NO measured in the perfusate liquid from the heart and serum citrulline, nitrites/nitrates were decreased in MS and AGE increased them (p< 0.01). In conclusion, AGE reduces MS-induced cardiovascular risk, through its anti-oxidant properties.
authors: Department of Pathology, Instituto Nacional de Cardiología "Ignacio Chávez", Juan Badiano 1, Sección XVI, Tlalpan, Mexico City 14080, Mexico. pertorisr@yahoo.com.mx.
authors: Israel
authors: I
authors: Pérez-Torres
authors: Department of Pharmacology, Instituto Nacional de Cardiología "Ignacio Chávez", Juan Badiano 1, Sección XVI, Tlalpan, Mexico City 14080, Mexico. juancarlostn63@hotmail.com.
authors: Juan Carlos
authors: JC
authors: Torres-Narváez
authors: Facultad de Química, Department of Biology, Edificio B, Segundo Piso, Laboratorio 209, Universidad Nacional Autónoma de México (UNAM), Ciudad Universitaria, Mexico City 04510, Mexico. pedraza@unam.mx.
authors: José
authors: J
authors: Pedraza-Chaverri
authors: Department of Physiology, Instituto Nacional de Cardiología "Ignacio Chávez", Juan Badiano 1, Sección XVI, Tlalpan, Mexico City 14080, Mexico. esther_rubio_ruiz@yahoo.com.
authors: María Esther
authors: ME
authors: Rubio-Ruiz
authors: Department of Reproductive Biology, Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán", Vasco de Quiroga 15, Sección XVI, Tlalpan, Mexico City 14000, Mexico. eulisesd@yahoo.com.
authors: Eulises
authors: E
authors: Díaz-Díaz
authors: Department of Pharmacology, Instituto Nacional de Cardiología "Ignacio Chávez", Juan Badiano 1, Sección XVI, Tlalpan, Mexico City 14080, Mexico. leonardodvm65@hotmail.com.
authors: Leonardo
authors: L
authors: Del Valle-Mondragón
authors: Electromechanical Instrumentation, Instituto Nacional de Cardiología "Ignacio Chávez", Juan Badiano 1, Sección XVI, Tlalpan, Mexico City 14080, Mexico. raulmmemije@yahoo.com.
authors: Raúl
authors: R
authors: Martínez-Memije
authors: Department of Physiology, Instituto Nacional de Cardiología "Ignacio Chávez", Juan Badiano 1, Sección XVI, Tlalpan, Mexico City 14080, Mexico. varelopz@yahoo.com.
authors: Elvira
authors: E
authors: Varela López
authors: Department of Physiology, Instituto Nacional de Cardiología "Ignacio Chávez", Juan Badiano 1, Sección XVI, Tlalpan, Mexico City 14080, Mexico. gualanv@yahoo.com.
authors: Verónica
authors: V
authors: Guarner-Lans
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage* / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D004195:Disease Models, Animal; D005737:Garlic / Q000737:chemistry*; D017127:Glycation End Products, Advanced / Q000378:metabolism; D006334:Heart Function Tests / Q000187:drug effects*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D024821:Metabolic Syndrome / Q000188:drug therapy* / Q000503:physiopathology; D010936:Plant Extracts / Q000008:administration & dosage* / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D014280:Triglycerides / Q000097:blood
chemical_list: D000975:Antioxidants; D017127:Glycation End Products, Advanced; D010936:Plant Extracts; D014280:Triglycerides; D002784:Cholesterol
keywords: aged garlic extract; cardiovascular functioning; metabolic syndrome; oxidative stress