title: Lipid-based nanocarriers for the oral administration of biopharmaceutics.
abstract: Biopharmaceutics have been recognized as the drugs of choice for the treatment of several diseases, mainly due to their high selectivity and potent action. Nonetheless, their oral administration is a rather challenging problem, since their bioavailability is significantly hindered by various physiological barriers along the GI tract, including their acid-induced hydrolysis in the stomach, their enzymatic degradation throughout the GI tract and their poor mucosa permeability. Lipid-based nanocarriers represent a viable means for enhancing the oral bioavailability of biomolecules while diminishing toxicity-related issues. The present review describes the main physiological barriers limiting the oral bioavailability of macromolecules and highlights recent advances in the field of lipid-based carriers as well as the respective lipid intestinal absorption mechanisms.
authors: Department of Chemical Engineering, Aristotle University of Thessaloniki, PO Box 472, 54124 Thessaloniki, Greece.
authors: Theodora
authors: T
authors: Karamanidou
authors: Department of Chemical Engineering, Aristotle University of Thessaloniki, PO Box 472, 54124 Thessaloniki, Greece.
authors: Vassilis
authors: V
authors: Bourganis
authors: Chemical Process & Energy Resources Institute, Centre for Research & Technology Hellas, PO Box 60361, 57001 Thessaloniki, Greece.
authors: Olga
authors: O
authors: Kammona
authors: Department of Chemical Engineering, Aristotle University of Thessaloniki, PO Box 472, 54124 Thessaloniki, Greece.|Chemical Process & Energy Resources Institute, Centre for Research & Technology Hellas, PO Box 60361, 57001 Thessaloniki, Greece.
authors: Costas
authors: C
authors: Kiparissides
mesh_terms: D000284:Administration, Oral; D001702:Biopharmaceutics; D004337:Drug Carriers / Q000008:administration & dosage / Q000737:chemistry*; D041981:Gastrointestinal Tract / Q000187:drug effects / Q000502:physiology; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects; D008055:Lipids / Q000008:administration & dosage / Q000737:chemistry*; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry*
chemical_list: D004337:Drug Carriers; D008055:Lipids
keywords: SEDDS; biopharmaceutics; emulsions; lipid-based drug delivery systems; liposomes; oral delivery; solid lipid particles