title: The crosstalk between microRNAs and the Wnt/β-catenin signaling pathway in cancer.
abstract: Mounting evidence has indicated microRNA (miR) dysregulation and the Wnt/β-catenin signaling pathway jointly drive carcinogenesis, cancer metastasis, and drug-resistance. The current review will focus on the role of the crosstalk between miRs and the Wnt/β-catenin signaling pathway in cancer development. MiRs were found to activate or inhibit the canonical Wnt pathway at various steps. On the other hand, Wnt activation increases expression of miR by directly binding to its promoter and activating transcription. Moreover, there are mutual feedback loops between some miRs and the Wnt/β-catenin signaling pathway. Clinical trials of miR-based therapeutic agents are investigated for solid and hematological tumors, however, challenges concerning low bioavailability and possible side effects must be overcome before the final clinical application. This review will describe current understanding of miR crosstalk with the Wnt/β-catenin signaling cascade. Better understanding of the regulatory network will provide insight into miR-based therapeutic development.
authors: Department of Pathology, The Shenzhen University School of Medicine, Shenzhen, Guangdong, People's Republic of China.|Department of Pathology, Wuhan University School of Basic Medical Sciences, Hubei, People's Republic of China.
authors: Yin
authors: Y
authors: Peng
authors: Department of Pathology, The Shenzhen University School of Medicine, Shenzhen, Guangdong, People's Republic of China.|Shenzhen Key Laboratory of Translational Medicine in Tumors, The Shenzhen University School of Medicine, Shenzhen, Guangdong, People's Republic of China.
authors: Xiaojing
authors: X
authors: Zhang
authors: Department of Pathology, The Shenzhen University School of Medicine, Shenzhen, Guangdong, People's Republic of China.
authors: Xianling
authors: X
authors: Feng
authors: Department of Pathology, The Shenzhen University School of Medicine, Shenzhen, Guangdong, People's Republic of China.
authors: Xinmim
authors: X
authors: Fan
authors: Department of Pathology, The Shenzhen University School of Medicine, Shenzhen, Guangdong, People's Republic of China.|Shenzhen Key Laboratory of Micromolecule Innovatal Drugs, The Shenzhen University School of Medicine, Shenzhen, Guangdong, People's Republic of China.|Shenzhen Key Laboratory of Translational Medicine in Tumors, The Shenzhen University School of Medicine, Shenzhen, Guangdong, People's Republic of China.
authors: Zhe
authors: Z
authors: Jin
mesh_terms: D000818:Animals; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D020239:Receptor Cross-Talk / Q000502:physiology*; D060449:Wnt Signaling Pathway / Q000502:physiology*
chemical_list: D035683:MicroRNAs
keywords: Wnt/β-catenin signaling pathway; cancer; microRNA