title: Genotypic and phenotypic heterogeneity inStreptococcus mutansisolated from diabetic patients in Rome, Italy.
abstract: Our study focuses on the antimicrobial susceptibility, genotypic and phenotypic heterogeneity, and serotype classification of theStreptococcus mutansisolated from type II diabetic patients (n = 25; age 42-68). Eighty-two percent of isolates were classified as serotypec. No serotypekwas present. Macrorestriction analysis of genomic DNA of the isolates exhibited a clonal diversity that paralleled the phenotypic heterogeneity, which was also assessed in terms of biofilm forming ability. Isolates were susceptible to all the classes of antibiotics. In conclusion a great heterogeneity and no antimicrobial resistance were apparent in the consideredS. mutansstrains from diabetic patients.
authors: Microbiology Unit, School of Pharmacy, University of Camerino, Via Gentile III da Varano, 62032 Camerino, MC Italy.
authors: Arpan
authors: A
authors: De
authors: Department of Clinical Science and Translational Medicine, University of Rome Tor Vergata, Rome, Italy.
authors: Guido
authors: G
authors: Pasquantonio
authors: Department of Clinical Science and Translational Medicine, University of Rome Tor Vergata, Rome, Italy.
authors: Loredana
authors: L
authors: Cerroni
authors: School of Biosciences and Veterinary Medicine, University of Camerino, Camerino, Italy.
authors: Dezemona
authors: D
authors: Petrelli
authors: Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
authors: Davide
authors: D
authors: Lauro
authors: Department of Clinical Science and Translational Medicine, University of Rome Tor Vergata, Rome, Italy.
authors: Marta
authors: M
authors: Longhi
authors: Microbiology Unit, School of Pharmacy, University of Camerino, Via Gentile III da Varano, 62032 Camerino, MC Italy.
authors: Luca A
authors: 0000-0002-3367-6088
authors: LA
authors: Vitali
keywords: Antimicrobial susceptibility; Caries; PFGE; Plaque