title: p53 partners with RNA in the DNA damage response.
abstract: Stabilization of p53 protein is a key step in the cellular response to DNA damage. A new study describes a long noncoding RNA, DINO, transcribed from the CDKN1A promoter region that induces stabilization of p53 protein and promotes efficient activation of p53 target genes in response to DNA damage.
authors: Center for Applied Medical Research (CIMA), Department of Gene Therapy and Regulation of Gene Expression, University of Navarra and the Institute of Health Research of Navarra (IdiSNA), Pamplona, Spain.
authors: Maite
authors: M
authors: Huarte
mesh_terms: D050759:Cyclin-Dependent Kinase Inhibitor p21 / Q000235:genetics*; D004249:DNA Damage / Q000235:genetics; D006801:Humans; D011401:Promoter Regions, Genetic; D055550:Protein Stability; D062085:RNA, Long Noncoding / Q000235:genetics*; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis / Q000235:genetics*
chemical_list: D050759:Cyclin-Dependent Kinase Inhibitor p21; C000619299:DINOL lncRNA, human; D062085:RNA, Long Noncoding; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53