title: Age of onset of obesity and risk of type 2 diabetes.
abstract: OBJECTIVE
  To compare a simple measure - age of onset of obesity - to an obese-years construct (a product of duration and magnitude of obesity) as risk factors for type 2 diabetes.
  
  
  METHODS
  Participants from the Framingham Heart Study who were not obese and did not have diabetes at baseline were included (n=4,320). The Akaike Information Criterion (AIC) was computed to compare four Cox proportional hazards models with incident diabetes as the outcome and: (i) obese-years; (ii) age of onset of obesity; (iii) body mass index (BMI); and (iv) age of onset of obesity plus magnitude of BMI combined, as exposures.
  
  
  RESULTS
  AIC indicated that the model with obese-years provided a more effective explanation of incidence of type 2 diabetes compared to the remaining three models. Models including age of onset of obesity plus BMI were not appreciably different from the model with BMI alone, except in those aged ≥60.
  
  
  CONCLUSIONS
  While obese-years was the optimal obesity construct to explain risk of type 2 diabetes, age of onset may be a useful, practical addition to current BMI in the elderly.
  
  
  CONCLUSIONS
  Where computation of obese-years is not possible or impractical, age of onset of obesity combined with BMI may provide a useful alternative.
authors: Baker IDI Heart and Diabetes Institute, Victoria.
authors: Stephanie K
authors: SK
authors: Tanamas
authors: Baker IDI Heart and Diabetes Institute, Victoria.|Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Victoria.
authors: Evelyn
authors: E
authors: Wong
authors: Baker IDI Heart and Diabetes Institute, Victoria.|Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Victoria.
authors: Kathryn
authors: K
authors: Backholer
authors: Department of Biostatistics and Population Health, Faculty of Public Health, University Muhammadiyah Aceh, Indonesia.|Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Victoria.
authors: Asnawi
authors: A
authors: Abdullah
authors: Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Victoria.
authors: Rory
authors: R
authors: Wolfe
authors: School of Population Health, University of Queensland.
authors: Jan
authors: J
authors: Barendregt
authors: Baker IDI Heart and Diabetes Institute, Victoria.|Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Victoria.
authors: Anna
authors: A
authors: Peeters
mesh_terms: D000328:Adult; D017668:Age of Onset; D003924:Diabetes Mellitus, Type 2; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity; D016016:Proportional Hazards Models
keywords: age of onset; body mass index; obese-years; obesity; type 2 diabetes