title: Comprehensive Three-Dimensional Analysis of the Neuroretinal Rim in Glaucoma Using High-Density Spectral-Domain Optical Coherence Tomography Volume Scans.
abstract: OBJECTIVE
  To describe spectral-domain optical coherence tomography (OCT) methods for quantifying neuroretinal rim tissue in glaucoma and to compare these methods to the traditional retinal nerve fiber layer thickness diagnostic parameter.
  
  
  METHODS
  Neuroretinal rim parameters derived from three-dimensional (3D) volume scans were compared with the two-dimensional (2D) Spectralis retinal nerve fiber layer (RNFL) thickness scans for diagnostic capability. This study analyzed one eye per patient of 104 glaucoma patients and 58 healthy subjects. The shortest distances between the cup surface and the OCT-based disc margin were automatically calculated to determine the thickness and area of the minimum distance band (MDB) neuroretinal rim parameter. Traditional 150-μm reference surface-based rim parameters (volume, area, and thickness) were also calculated. The diagnostic capabilities of these five parameters were compared with RNFL thickness using the area under the receiver operating characteristic (AUROC) curves.
  
  
  RESULTS
  The MDB thickness had significantly higher diagnostic capability than the RNFL thickness in the nasal (0.913 vs. 0.818, P = 0.004) and temporal (0.922 vs. 0.858, P = 0.026) quadrants and the inferonasal (0.950 vs. 0.897, P = 0.011) and superonasal (0.933 vs. 0.868, P = 0.012) sectors. The MDB area and the three neuroretinal rim parameters based on the 150-μm reference surface had diagnostic capabilities similar to RNFL thickness.
  
  
  CONCLUSIONS
  The 3D MDB thickness had a high diagnostic capability for glaucoma and may be of significant clinical utility. It had higher diagnostic capability than the RNFL thickness in the nasal and temporal quadrants and the inferonasal and superonasal sectors.
authors: Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States 2Harvard Medical School, Boston, Massachusetts, United States.
authors: Edem
authors: E
authors: Tsikata
authors: Harvard Medical School, Boston, Massachusetts, United States.
authors: Ramon
authors: R
authors: Lee
authors: Harvard Medical School, Boston, Massachusetts, United States.
authors: Eric
authors: E
authors: Shieh
authors: Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States 2Harvard Medical School, Boston, Massachusetts, United States 3Pamukkale Üniversitesi Hastanesi, Denizli, Turkey.
authors: Huseyin
authors: H
authors: Simavli
authors: Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States 2Harvard Medical School, Boston, Massachusetts, United States.
authors: Christian J
authors: CJ
authors: Que
authors: Biostatistics, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States.
authors: Rong
authors: R
authors: Guo
authors: Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States 2Harvard Medical School, Boston, Massachusetts, United States.
authors: Ziad
authors: Z
authors: Khoueir
authors: LaserLaB Amsterdam, Department of Physics and Astronomy, Vrije Universiteit, Amsterdam, The Netherlands 6Department of Ophthalmology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands.
authors: Johannes
authors: J
authors: de Boer
authors: Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States 2Harvard Medical School, Boston, Massachusetts, United States.
authors: Teresa C
authors: TC
authors: Chen
mesh_terms: D000368:Aged; D003430:Cross-Sectional Studies; D005260:Female; D005500:Follow-Up Studies; D005901:Glaucoma / Q000175:diagnosis*; D006801:Humans; D021621:Imaging, Three-Dimensional; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology*; D011446:Prospective Studies; D012372:ROC Curve; D012165:Retinal Ganglion Cells / Q000473:pathology*; D041623:Tomography, Optical Coherence / Q000379:methods*