title: [Programmed necrosis mediated by receptor-interacting protein 3: a new target for liver disease research].
abstract: Hepatocyte death mainly includes apoptosis and necrosis and is a critical process in the pathophysiological mechanism of liver injury caused by various reasons. Recent studies have shown that key regulatory molecules in the inhibition of apoptosis such as caspase cannot be used as targets for inhibiting disease progression in clinical practice. In recent years, programmed necrosis mediated by receptor-interacting protein 3(RIP3)becomes a new hot research topic. It not only plays an important role in inducing inflammatory response, but also is closely regulated by intracellular signal factors, and it is a type of active cell death which can be interfered with. Compared with apoptosis, programmed necrosis is accompanied by the release of various inflammatory factors, which significantly affects local immune microenvironment. RIP3-mediated programmed necrosis has been taken seriously in many diseases. Although its mechanism of action in liver disease remains unclear, the results of recent studies confirmed its important role in the development of liver disease. This article reviews the research advances in the role of RIP3-mediated programmed necrosis signaling pathway in liver disease of various causes and investigates the possibility of RIP3-mediated programmed necrosis as a new target in the treatment of liver disease.
authors: Department of Gastroenterology and Hepatology. Tianjin Medical University General Hospital, Tianjin 300052, China.
authors: J
authors: J
authors: Zhang
authors: Y
authors: Y
authors: Jing
authors: Y N
authors: YN
authors: Li
authors: L
authors: L
authors: Zhou
authors: B M
authors: BM
authors: Wang
mesh_terms: D000818:Animals; D017209:Apoptosis; D053181:Caspase 8 / Q000378:metabolism; D061945:Caspase Inhibitors / Q000494:pharmacology*; D016923:Cell Death; D022781:Hepatocytes; D006801:Humans; D008107:Liver Diseases; D009336:Necrosis / Q000378:metabolism* / Q000473:pathology; D053422:Receptor-Interacting Protein Serine-Threonine Kinases; D015398:Signal Transduction; D051193:Toll-Like Receptors / Q000378:metabolism*
chemical_list: D061945:Caspase Inhibitors; D051193:Toll-Like Receptors; C119705:RIPK3 protein, human; D053422:Receptor-Interacting Protein Serine-Threonine Kinases; D053181:Caspase 8