title: Fabrication of silver nanowires-loaded polydimethylsiloxane film with antimicrobial activities and cell compatibility.
abstract: Microbial contamination on various surfaces is one of the greatest health problems worldwide, afflicting millions of peoples annually. Given the advantages of silver nanowires (AgNWs) in forming a percolated network when fabricated into a film, there is significant interest in developing AgNWs loaded polymeric coatings for antimicrobial applications. In this work, AgNWs with high aspect ratio are drop-coated onto a silicon wafer to form a uniform interconnected network. The AgNW network is then embedded into polydimethylsiloxane (PDMS) matrix to fabricate AgNWs/PDMS film. The PDMS loaded with various amounts of AgNWs can efficiently destroy Escherichia coli and Staphylococcus aureus bacteria, and PDMS with 0.2mg of AgNW loading (i.e. 50μgcm-2) exhibit excellent cell compatibility. Furthermore, AgNWs/PDMS films show a long-term antibacterial effect for at least one month. The utilization of AgNWs in polymeric coatings provides a novel platform to reduce the microorganism infection.
authors: College of Chemistry, Jilin University, Changchun 130012, PR China. Electronic address: sjiang@jlu.edu.cn.
authors: Shan
authors: S
authors: Jiang
authors: Institute of Materials Research and Engineering, A*STAR (Agency for Science, Technology and Research), 2 Fusionopolis Way, 138634, Singapore.
authors: Choon Peng
authors: CP
authors: Teng
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D004129:Dimethylpolysiloxanes / Q000737:chemistry*; D004926:Escherichia coli / Q000187:drug effects; D005347:Fibroblasts / Q000166:cytology* / Q000187:drug effects; D006801:Humans; D008422:Materials Testing; D008826:Microbial Sensitivity Tests; D036103:Nanotechnology / Q000379:methods*; D053770:Nanowires / Q000737:chemistry*; D012834:Silver / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000890:Anti-Infective Agents; D004129:Dimethylpolysiloxanes; D012834:Silver
keywords: Antibacterial and cell compatibility; Antimicrobial; PDMS film; Silver nanowires