title: [Role of FibroScan in liver fibrosis evaluation in patients with chronic hepatitis B virus infection and related influencing factors].
abstract: Objective:To investigate the role of FibroScan(FS)in liver fibrosis evaluation in patients with chronic hepatitis B virus(HBV)infection and related influencing factors.Methods:A total of 313 patients with chronic HBV infection were enrolled, and liver tissue was obtained through ultrasound-guided"1-second fast tissue cutting". The liver stiffness measurement(LSM)was determined by FS, serum HBeAg and liver function were measured, and the patients' demographic data were recorded. Thet-test was used for comparison of normally distributed data between groups, and the Mann-Whitney U test was used for comparison of non-normally distributed data between groups; the Spearman or Pearson correlation coefficient was used for correlation analysis; the ROC curve and AUC were used to evaluate the efficiency of FS in the diagnosis of liver fibrosis ≥S2.Results:LSM was positively correlated with liver inflammation grade and fibrosis stage(r= 0.428 and 0.402 in HBeAg-positive group andr= 0.296 and 0.283 in HBeAg-negative group, allP< 0.001). The correlation of LSM with sex, age, alanine aminotransferase(ALT)level, and total bilirubin(TBil)was affected by HBeAg status and ALT level, and LSM was only positively correlated with TBil in HBeAg-negative group(r= 0.298,P< 0.001). In patients with ALT ≥2×upper limit of normal(ULN), FS had a low efficiency in the diagnosis of liver fibrosis ≥S2(AUC < 0.75,P> 0.05), regardless of their HBeAg status. The cut-off values of FS in the diagnosis of liver fibrosis ≥S2 varied with ALT level and HBeAg status, and in the ALT <1×ULN and 1-2×ULN groups, the cut-off values of FS in the diagnosis of liver fibrosis ≥S2 in patients with positive and negative HBeAg were 5.85 kPa/7.3 kPa and 6.35 kPa/8.5 kPa, respectively. In the patients with positive HBeAg in ALT < 2×ULN group, LSM was positively correlated with age(r= 0.278,P= 0.014). FS had relatively high diagnostic efficiency in patients aged > 30 years(AUC = 0.867,P< 0.001)and low diagnostic efficiency in patients aged≤30 years(AUC = 0.632,P> 0.05).Conclusion:LSM is positively correlated with liver inflammation grade and fibrosis stage. The cut-off value of FS in the diagnosis of marked liver fibrosis is affected by age, ALT level, and HBeAg status. FS has low diagnostic efficiency in patients aged ≤30 years.
authors: Department of Infectious Diseases, The First Affiliated Hospital of Anhui Medical University, Hefei 230032, China.
authors: Q X
authors: QX
authors: Xie
authors: N
authors: N
authors: Xu
authors: X P
authors: XP
authors: Jiang
authors: Y F
authors: YF
authors: Zhang
authors: Z H
authors: ZH
authors: Zhang
authors: J B
authors: JB
authors: Li
authors: X Y
authors: XY
authors: Hu
authors: X
authors: X
authors: Li
mesh_terms: D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D015415:Biomarkers / Q000097:blood; D002908:Chronic Disease; D004548:Elasticity; D054459:Elasticity Imaging Techniques; D005260:Female; D006513:Hepatitis B e Antigens; D019694:Hepatitis B, Chronic / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging* / Q000473:pathology; D008103:Liver Cirrhosis / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D012698:Serologic Tests
chemical_list: D015415:Biomarkers; D006513:Hepatitis B e Antigens; D000410:Alanine Transaminase