title: Magnetic resonance imaging of pulmonary infection in immunocompromised children: comparison with multidetector computed tomography.
abstract: BACKGROUND
  Computed tomography (CT) is commonly used to detect pulmonary infection in immunocompromised children.
  
  
  OBJECTIVE
  To compare MRI and multidetector CT findings of pulmonary abnormalities in immunocompromised children.
  
  
  METHODS
  Seventeen neutropaenic children (6 girls; ages 2-18 years) were included. Non-contrast-enhanced CT was performed with a 64-detector CT scanner. Axial and coronal non-enhanced thoracic MRI was performed using a 1.5-T scanner within 24 h of the CT examination (true fast imaging with steady-state free precession, fat-saturated T2-weighted turbo spin echo with motion correction, T2-weighted half-Fourier single-shot turbo spin echo [HASTE], fat-saturated T1-weighted spoiled gradient echo). Pulmonary abnormalities (nodules, consolidations, ground glass opacities, atelectasis, pleural effusion and lymph nodes) were evaluated and compared among MRI sequences and between MRI and CT. The relationship between MRI sequences and nodule sizes was examined by chi- square test.
  
  
  RESULTS
  Of 256 CT lesions, 207 (81%, 95% confidence interval [CI] 76-85%) were detected at MRI. Of 202 CT-detected nodules, 157 (78%, 95% CI 71-83%) were seen at motion-corrected MRI. Of the 1-5-mm nodules, 69% were detected by motion-corrected T2-weighted MRI and 38% by HASTE MRI.
  
  
  CONCLUSIONS
  Sensitivity of MRI (both axial fat-saturated T2-weighted turbo spin echo with variable phase encoding directions (BLADE) images and HASTE sequences) to detect pulmonary abnormalities is promising.
authors: Department of Radiology, Hacettepe University School of Medicine, Sihhiye, 06100, Ankara, Turkey.
authors: H Nursun
authors: HN
authors: Ozcan
authors: Department of Radiology, Hacettepe University School of Medicine, Sihhiye, 06100, Ankara, Turkey.
authors: Ayşegul
authors: A
authors: Gormez
authors: Department of Pediatric Infectious Disease, Hacettepe University School of Medicine, Ankara, Turkey.
authors: Yasemin
authors: Y
authors: Ozsurekci
authors: Department of Biostatistics, Hacettepe University School of Medicine, Ankara, Turkey.
authors: Jale
authors: J
authors: Karakaya
authors: Department of Radiology, Hacettepe University School of Medicine, Sihhiye, 06100, Ankara, Turkey.
authors: Berna
authors: B
authors: Oguz
authors: Department of Pediatric Hematology, Hacettepe University School of Medicine, Ankara, Turkey.
authors: Sule
authors: S
authors: Unal
authors: Department of Pediatric Hematology, Hacettepe University School of Medicine, Ankara, Turkey.
authors: Mualla
authors: M
authors: Cetin
authors: Department of Pediatric Infectious Disease, Hacettepe University School of Medicine, Ankara, Turkey.
authors: Mehmet
authors: M
authors: Ceyhan
authors: Department of Radiology, Hacettepe University School of Medicine, Sihhiye, 06100, Ankara, Turkey. mithath@hacettepe.edu.tr.
authors: Mithat
authors: M
authors: Haliloglu
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D019337:Hematologic Neoplasms / Q000150:complications*; D006801:Humans; D016867:Immunocompromised Host; D007223:Infant; D008171:Lung Diseases / Q000000981:diagnostic imaging* / Q000382:microbiology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D061330:Multidetector Computed Tomography / Q000379:methods*; D011446:Prospective Studies; D012680:Sensitivity and Specificity
keywords: Children; Computed tomography; Consolidation; Detection rate; Immunosuppression; Lung; Lung nodules; Magnetic resonance imaging; Pulmonary infection