title: A Short Diastereoselective Total Synthesis of (±)-Vibralactone.
abstract: A total synthesis of the (±)-vibralactone has been achieved in 11 steps and 16% overall yield from malonic acid. Key steps include a highly diastereoselective allylation of an α-formyl ester containing an all carbon α-quaternary center, a Pd-catalyzed deallylative β-lactonization, and an aldehyde-selective Wacker oxidation of a terminal alkene.
authors: Department of Chemistry, University of Southampton , Southampton, Hampshire SO17 1BJ, U.K.
authors: Alexander J
authors: AJ
authors: Leeder
authors: Department of Chemistry, University of Southampton , Southampton, Hampshire SO17 1BJ, U.K.
authors: Robert J
authors: RJ
authors: Heap
authors: Department of Chemistry, University of Southampton , Southampton, Hampshire SO17 1BJ, U.K.
authors: Lynda J
authors: LJ
authors: Brown
authors: Normandie Université, COBRA, UMR 6014 & FR 3038; Rouen-Normandie Université; INSA Rouen; CNRS, 1 rue Tesnière 76821 Mont-Saint-Aignan, Cedex, France.
authors: Xavier
authors: X
authors: Franck
authors: Department of Chemistry, University of Southampton , Southampton, Hampshire SO17 1BJ, U.K.
authors: Richard C D
authors: RC
authors: Brown