title: CLOSTRIDIAL PARAPROCTITIS WITH GAS GANGRENE OF FRONT-LATERAL ABDOMINAL WALLS AND NECROTIC FASCIO-MYOSITIS (CASE REPORT).
abstract: Anaerobic clostridial infection is the most severe form of paraproctitis. The incubation period is very short, from 3 to 6 hours, sometimes lasting for 1-2 days. Clostridial infection spreads rapidly and induces gas gangrene, causes destruction of cells and other intermediate substances, and impedes blood circulation. This paper presents a case study of an extremely severe form of anaerobic infection with spontaneous gas gangrene, cellulitis, fasciomyositic necrosis, severe intoxication and septic shock on the abdominal front and lateral surfaces. This patient presented as infected with Clostridium septicum, a rare and highly toxic Gram-positive, spore-forming, obligate anaerobic bacillus that progresses and migrates rapidly, affecting all soft tissues (muscle, fascia), and produces four toxins which cause gas gangrene, intravascular hemolysis, tissue necrosis, and septic shock. The mortality rate is typically 80%. In this case study, a positive clinical outcome was achieved by aggressive identification of the microbe, appropriate and immediate therapy, and vigorous surgical intervention. Specifically, immediate surgery was conducted to ensure a wide excision of damaged tissues, necrectomy, curettage, wide drainage, readjustment, oxygenation through drainages, further additional surgical corrections through CT control with wide bandages in the operating area. Further, the diagnostic workup was thorough, identifying the microbe through a properly constructed diagnostic algorithm, ultrasound and CT studies, infectious agent assessments, and bacteriological monitoring carried out on the 1st-2nd-5th-7th-12th-15th-21st-25th days. Rational antibiotic therapy with permanent susceptibility testing informed the selection of an appropriate agent. Finally, markers for the evaluation of severity (Apache scale) were assessed, as they were for stage of infection (prokalcitonin), inflammation (CRP) and other indicators.
authors: Tbilisi State Medical University; The First University Clinic, Georgia.
authors: N
authors: N
authors: Didbaridze
authors: Tbilisi State Medical University; The First University Clinic, Georgia.
authors: N
authors: N
authors: Lomidze
authors: Tbilisi State Medical University; The First University Clinic, Georgia.
authors: T
authors: T
authors: Abuladze
authors: Tbilisi State Medical University; The First University Clinic, Georgia.
authors: G
authors: G
authors: Qiliptari
authors: Tbilisi State Medical University; The First University Clinic, Georgia.
authors: T
authors: T
authors: Didbaridze
authors: Tbilisi State Medical University; The First University Clinic, Georgia.
authors: I
authors: I
authors: Gvasalia
authors: Tbilisi State Medical University; The First University Clinic, Georgia.
authors: Z
authors: Z
authors: Mkervalishvili
authors: Tbilisi State Medical University; The First University Clinic, Georgia.
authors: N
authors: N
authors: Gogokhia
mesh_terms: D034861:Abdominal Wall; D000328:Adult; D003015:Clostridium Infections / Q000150:complications / Q000175:diagnosis* / Q000382:microbiology; D052557:Clostridium septicum / Q000302:isolation & purification; D019115:Fasciitis, Necrotizing / Q000150:complications / Q000175:diagnosis*; D005738:Gas Gangrene / Q000175:diagnosis* / Q000209:etiology; D006801:Humans; D008297:Male; D009220:Myositis / Q000150:complications / Q000175:diagnosis*; D011349:Proctitis / Q000150:complications / Q000175:diagnosis* / Q000382:microbiology