title: miR-203 facilitates tumor growth and metastasis by targeting fibroblast growth factor 2 in breast cancer.
abstract: Breast cancer is the second leading cause of cancer mortality in women worldwide. Molecular therapy is needed to improve the outcome in patients with breast cancer. miR-203 participates in cancer cell proliferation, transformation, and apoptosis. This study showed that miR-203 was upregulated in breast cancer tissues and the MCF-7 cell line. miR-203 knockdown suppressed colony formation and transformation and also limited migration in MCF-7 cells. Fibroblast growth factor 2 (FGF2) was confirmed as a novel target of miR-203, as miR-203 knockdown induced an enhanced expression of FGF2 in MCF-7 cells. Moreover, FGF2 can reverse transforming growth factor-β signal pathway to suppress breast cancer. These findings provide new insights with potential therapeutic applications for the treatment of breast cancer.
authors: Department of Pathology, Qianfoshan Hospital Affiliated to Shandong University, Jinan, Shandong, People's Republic of China.
authors: Shuqian
authors: S
authors: He
authors: Department of Pathology, Qianfoshan Hospital Affiliated to Shandong University, Jinan, Shandong, People's Republic of China.
authors: Guihui
authors: G
authors: Zhang
authors: Department of Pathology, Qianfoshan Hospital Affiliated to Shandong University, Jinan, Shandong, People's Republic of China.
authors: He
authors: H
authors: Dong
authors: Department of Pathology, Qianfoshan Hospital Affiliated to Shandong University, Jinan, Shandong, People's Republic of China.
authors: Maoqiang
authors: M
authors: Ma
authors: Department of Pathology, Qianfoshan Hospital Affiliated to Shandong University, Jinan, Shandong, People's Republic of China.
authors: Qing
authors: Q
authors: Sun
keywords: FGF2; breast cancer; miR-203