title: Levodopa-induced morphologic changes of prefrontal pyramidal tract-type neurons in a rat model of Parkinson's disease.
abstract: Long-term administration of levodopa for Parkinson's disease is associated with various motor and non-motor complications. We examined the dendritic spine morphology of pyramidal tract-type neurons in the prefrontal cortex in a rat model of Parkinson's disease chronically treated with levodopa. Dendritic spines showed decreased density and increased average volume after dopamine denervation and levodopa treatment. These morphologic alterations suggest that the prefrontal neurons may maladaptively respond to excitatory input, which might be one of the mechanisms underlying various levodopa-induced complications in patients with Parkinson's disease.
authors: Department of Neurology, Aomori Prefectural Central Hospital, 2-1-1 Higashi-tsukurimichi, Aomori 030-8553, Japan; Department of Neurophysiology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki 306-8562, Japan. Electronic address: hnishijima-tky@umin.ac.jp.
authors: Haruo
authors: H
authors: Nishijima
authors: Department of Neurology, Aomori Prefectural Central Hospital, 2-1-1 Higashi-tsukurimichi, Aomori 030-8553, Japan; Department of Neurophysiology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki 306-8562, Japan.
authors: Tatsuya
authors: T
authors: Ueno
authors: Department of Neurophysiology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki 306-8562, Japan.
authors: Shinya
authors: S
authors: Ueno
authors: Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki 306-8562, Japan.
authors: Fumiaki
authors: F
authors: Mori
authors: Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki 306-8562, Japan.
authors: Yasuo
authors: Y
authors: Miki
authors: Department of Neurology, Aomori Prefectural Central Hospital, 2-1-1 Higashi-tsukurimichi, Aomori 030-8553, Japan; Department of Neurophysiology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki 306-8562, Japan.
authors: Masahiko
authors: M
authors: Tomiyama
mesh_terms: D000818:Animals; D000978:Antiparkinson Agents / Q000009:adverse effects*; D049229:Dendritic Spines / Q000187:drug effects / Q000473:pathology; D015259:Dopamine Agents / Q000009:adverse effects*; D007980:Levodopa / Q000009:adverse effects*; D008297:Male; D009474:Neurons / Q000187:drug effects* / Q000473:pathology; D016627:Oxidopamine; D010300:Parkinson Disease / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D017397:Prefrontal Cortex / Q000187:drug effects* / Q000473:pathology; D011712:Pyramidal Tracts / Q000187:drug effects* / Q000473:pathology; D017208:Rats, Wistar
chemical_list: D000978:Antiparkinson Agents; D015259:Dopamine Agents; D007980:Levodopa; D016627:Oxidopamine
keywords: Dendritic spine; Dopamine dysregulation syndrome; Levodopa-induced dyskinesia; Parkinson’s disease; Prefrontal cortex; Synaptic plasticity