title: Asymmetric Peptide Nanoribbons.
abstract: Asymmetry in chemical structure or shape at molecular, nanoscale, or microscopic levels is essential to a vast number of functionalities in both natural and artificial systems. Bottom-up approaches to create asymmetric supramolecular nanostructures are considered promising but this strategy suffers from the potentially dynamic nature of noncovalent interactions. We report here on supramolecular self-assembly of asymmetric peptide amphiphiles consisting of two different molecularly linked domains. We found that strong noncovalent interactions and a high degree of internal order among the asymmetric amphiphiles lead to nanoribbons with asymmetric faces due to the preferential self-association of the two domains. The capture of gold nanoparticles on only one face of the nanoribbons demonstrates symmetry breaking in these supramolecular structures.
authors: Department of Chemistry, Northwestern University , Evanston, Illinois 60208, United States.
authors: Zhilin
authors: Z
authors: Yu
authors: Department of Materials Science and Engineering, Northwestern University , Evanston, Illinois 60208, United States.
authors: Faifan
authors: F
authors: Tantakitti
authors: Department of Chemistry, Northwestern University , Evanston, Illinois 60208, United States.|Simpson Querrey Institute for BioNanotechnology, Northwestern University , Chicago, Illinois 60611, United States.
authors: Liam C
authors: LC
authors: Palmer
authors: Department of Chemistry, Northwestern University , Evanston, Illinois 60208, United States.|Department of Materials Science and Engineering, Northwestern University , Evanston, Illinois 60208, United States.|Simpson Querrey Institute for BioNanotechnology, Northwestern University , Chicago, Illinois 60611, United States.|Department of Biomedical Engineering, Northwestern University , Evanston, Illinois 60208, United States.|Department of Medicine, Northwestern University , Chicago, Illinois 60611, United States.
authors: Samuel I
authors: SI
authors: Stupp
mesh_terms: D002122:Calcium Chloride / Q000737:chemistry; D004583:Electrons; D006046:Gold / Q000737:chemistry; D057927:Hydrophobic and Hydrophilic Interactions; D053768:Metal Nanoparticles / Q000737:chemistry; D037742:Nanotubes, Carbon / Q000737:chemistry*; D010316:Particle Size; D010455:Peptides / Q000737:chemistry*; D011487:Protein Conformation; D055503:Protein Multimerization; D012212:Rheology; D013499:Surface Properties; D013816:Thermodynamics
chemical_list: D037742:Nanotubes, Carbon; D010455:Peptides; D006046:Gold; D002122:Calcium Chloride
keywords: Asymmetric nanostructures; multidomain peptide amphiphiles; nanoribbons; supramolecular self-assembly