title: MDCT assessment of resectability in hilar cholangiocarcinoma.
abstract: The purpose of this study is to investigate the value of multidetector computed tomography (MDCT) assessment of resectability in hilar cholangiocarcinoma, and to identify the factors associated with unresectability and accurate evaluation of resectability.
  
  
  
  From January 2007 to June 2015, a total of 77 consecutive patients were included. All patients had preoperative MDCT (with MPR and MinIP) and surgical treatment, and were pathologically proven with hilar cholangiocarcinoma. The MDCT images were reviewed retrospectively by two senior radiologists and one hepatobiliary surgeon. The surgical findings and pathologic results were considered to be the gold standard. The Chi square test was used to identify factors associated with unresectability and accurate evaluation of resectability.
  
  
  
  The sensitivity, specificity, and overall accuracy of MDCT assessment were 83.3 %, 75.9 %, and 80.5 %, respectively. The main causes of inaccuracy were incorrect evaluation of N2 lymph node metastasis (4/15) and distant metastasis (4/15). Bismuth type IV tumor, main or bilateral hepatic artery involvement, and main or bilateral portal vein involvement were highly associated with unresectability (P < 0.001). Patients without biliary drainage had higher accuracy of MDCT evaluation of resectability compared to those with biliary drainage (P < 0.001).
  
  
  
  MDCT is reliable for preoperative assessment of resectability in hilar cholangiocarcinoma. Bismuth type IV tumor and main or bilateral vascular involvement highly suggest the unresectability of hilar cholangiocarcinoma. Patients without biliary drainage have a more accurate MDCT evaluation of resectability. We suggest MDCT should be performed before biliary drainage to achieve an accurate evaluation of resectability in hilar cholangiocarcinoma.
authors: Department of Biliary-pancreatic Surgery, School of Medicine, Ren Ji Hospital, Shanghai Jiao Tong University, 1630 S. Dongfang Road, Shanghai, 200127, China.
authors: Qihong
authors: Q
authors: Ni
authors: Department of Biliary-pancreatic Surgery, School of Medicine, Ren Ji Hospital, Shanghai Jiao Tong University, 1630 S. Dongfang Road, Shanghai, 200127, China.|Therapeutics Research Centre, School of Medicine, Princess Alexandra Hospital, The University of Queensland, Woolloongabba, Brisbane, QLD 4102, Australia.
authors: Haolu
authors: H
authors: Wang
authors: Department of Biliary-pancreatic Surgery, School of Medicine, Ren Ji Hospital, Shanghai Jiao Tong University, 1630 S. Dongfang Road, Shanghai, 200127, China.
authors: Yunhe
authors: Y
authors: Zhang
authors: Department of Radiology, School of Medicine, Ren Ji Hospital, Shanghai Jiao Tong University, 1630 S. Dongfang Road, Shanghai, 200127, China.
authors: Lijun
authors: L
authors: Qian
authors: Department of Radiology, School of Medicine, Ren Ji Hospital, Shanghai Jiao Tong University, 1630 S. Dongfang Road, Shanghai, 200127, China.
authors: Jiachang
authors: J
authors: Chi
authors: Therapeutics Research Centre, School of Medicine, Princess Alexandra Hospital, The University of Queensland, Woolloongabba, Brisbane, QLD 4102, Australia.
authors: Xiaowen
authors: X
authors: Liang
authors: Department of Biliary-pancreatic Surgery, School of Medicine, Ren Ji Hospital, Shanghai Jiao Tong University, 1630 S. Dongfang Road, Shanghai, 200127, China.
authors: Tao
authors: T
authors: Chen
authors: Department of Biliary-pancreatic Surgery, School of Medicine, Ren Ji Hospital, Shanghai Jiao Tong University, 1630 S. Dongfang Road, Shanghai, 200127, China. dr__wangjian@126.com.
authors: Jian
authors: J
authors: Wang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001650:Bile Duct Neoplasms / Q000000981:diagnostic imaging* / Q000601:surgery*; D001653:Bile Ducts, Intrahepatic / Q000000981:diagnostic imaging*; D018281:Cholangiocarcinoma / Q000000981:diagnostic imaging* / Q000601:surgery*; D003287:Contrast Media; D005260:Female; D006801:Humans; D007479:Iopamidol; D008297:Male; D008875:Middle Aged; D061330:Multidetector Computed Tomography; D011857:Radiographic Image Interpretation, Computer-Assisted; D012189:Retrospective Studies; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media; D007479:Iopamidol
keywords: Hilar cholangiocarcinoma; MDCT; Preoperative evaluation; Resectability