title: Lycopersicon esculentum Extract Enhances Cognitive Function and Hippocampal Neurogenesis in Aged Mice.
abstract: A decrease in adult neurogenesis is associated with the aging process, and this decrease is closely related to memory impairment. Tomato (Lycopersicon esculentum) is a fruit with diverse bioactive nutrients that is consumed worldwide. In this study, we investigated the cognition-enhancing effect of tomato ethanolic extracts (TEE) in aged mice. Six weeks of oral TEE administration in 12-month-old aged mice significantly increased their exploration time of novel objects when compared to vehicle-treated mice. The TEE supplement increased doublecortin (DCX)-positive cells and postsynaptic density-95 (PSD95) expression in mice hippocampus. Moreover, we found an increased expression of brain-derived neurotrophic factor (BDNF) and subsequently-activated extracellular-signal-regulated kinase (ERK)/cAMP response element binding (CREB) signaling pathway in the TEE-supplemented mice hippocampus. In conclusion, the oral administration of TEE exhibits a cognition-enhancing effect, and the putative underlying mechanism is the induction of BDNF signaling-mediated proliferation and synapse formation in the hippocampus. These findings indicate that TEE could be a candidate for treatment of age-related memory impairment and neurodegenerative disorders.
authors: Department of Dermatology, Seoul National University College of Medicine, 101, Daehak-ro Jongno-gu, Seoul 03080, Korea. ralral82@naver.com.|Laboratory of Cutaneous Aging Research, Biomedical Research Institute, Seoul National University Hospital, 101, Daehak-ro Jongno-gu, Seoul 03080, Korea. ralral82@naver.com.|Institute of Human-Environment Interface Biology, Seoul National University, 101, Daehak-ro Jongno-gu, Seoul 03080, Korea. ralral82@naver.com.
authors: Jung-Soo
authors: JS
authors: Bae
authors: Department of Dermatology, Seoul National University College of Medicine, 101, Daehak-ro Jongno-gu, Seoul 03080, Korea. mira0221@nate.com.|Laboratory of Cutaneous Aging Research, Biomedical Research Institute, Seoul National University Hospital, 101, Daehak-ro Jongno-gu, Seoul 03080, Korea. mira0221@nate.com.|Institute of Human-Environment Interface Biology, Seoul National University, 101, Daehak-ro Jongno-gu, Seoul 03080, Korea. mira0221@nate.com.
authors: Mira
authors: M
authors: Han
authors: Korea Food Research Institute, Seongnam-si, Kyeonggi-do 13539, Korea. hsshin@kfri.re.kr.|Food Biotechnology Program, Korea University of Science and Technology, Daejeon 34113, Korea. hsshin@kfri.re.kr.
authors: Hee Soon
authors: HS
authors: Shin
authors: Korea Food Research Institute, Seongnam-si, Kyeonggi-do 13539, Korea. dhs95@kfri.re.kr.|Food Biotechnology Program, Korea University of Science and Technology, Daejeon 34113, Korea. dhs95@kfri.re.kr.
authors: Dong-Hwa
authors: DH
authors: Shon
authors: Department of Neurology, Seoul National University College of Medicine, 101, Daehak-ro Jongno-gu, Seoul 03080, Korea. staelee@gmail.com.
authors: Soon-Tae
authors: ST
authors: Lee
authors: Department of Dermatology, Seoul National University College of Medicine, 101, Daehak-ro Jongno-gu, Seoul 03080, Korea. shiny69@empal.com.|Laboratory of Cutaneous Aging Research, Biomedical Research Institute, Seoul National University Hospital, 101, Daehak-ro Jongno-gu, Seoul 03080, Korea. shiny69@empal.com.|Institute of Human-Environment Interface Biology, Seoul National University, 101, Daehak-ro Jongno-gu, Seoul 03080, Korea. shiny69@empal.com.
authors: Chang-Yup
authors: CY
authors: Shin
authors: Department of Dermatology, Seoul National University College of Medicine, 101, Daehak-ro Jongno-gu, Seoul 03080, Korea. lepommier@snu.ac.kr.|Laboratory of Cutaneous Aging Research, Biomedical Research Institute, Seoul National University Hospital, 101, Daehak-ro Jongno-gu, Seoul 03080, Korea. lepommier@snu.ac.kr.|Institute of Human-Environment Interface Biology, Seoul National University, 101, Daehak-ro Jongno-gu, Seoul 03080, Korea. lepommier@snu.ac.kr.
authors: Yuri
authors: Y
authors: Lee
authors: Department of Dermatology, Seoul National University College of Medicine, 101, Daehak-ro Jongno-gu, Seoul 03080, Korea. ivymed27@snu.ac.kr.|Laboratory of Cutaneous Aging Research, Biomedical Research Institute, Seoul National University Hospital, 101, Daehak-ro Jongno-gu, Seoul 03080, Korea. ivymed27@snu.ac.kr.|Institute of Human-Environment Interface Biology, Seoul National University, 101, Daehak-ro Jongno-gu, Seoul 03080, Korea. ivymed27@snu.ac.kr.
authors: Dong Hun
authors: DH
authors: Lee
authors: Department of Dermatology, Seoul National University College of Medicine, 101, Daehak-ro Jongno-gu, Seoul 03080, Korea. jhchung@snu.ac.kr.|Laboratory of Cutaneous Aging Research, Biomedical Research Institute, Seoul National University Hospital, 101, Daehak-ro Jongno-gu, Seoul 03080, Korea. jhchung@snu.ac.kr.|Institute of Human-Environment Interface Biology, Seoul National University, 101, Daehak-ro Jongno-gu, Seoul 03080, Korea. jhchung@snu.ac.kr.|SNU Institute on Aging, Seoul National University, 101, Daehak-ro Jongno-gu, Seoul 03080, Korea. jhchung@snu.ac.kr.
authors: Jin Ho
authors: JH
authors: Chung
mesh_terms: D000375:Aging; D000818:Animals; D001522:Behavior, Animal; D015415:Biomarkers / Q000378:metabolism; D019208:Brain-Derived Neurotrophic Factor / Q000819:agonists / Q000235:genetics / Q000378:metabolism; D003071:Cognition; D019587:Dietary Supplements; D000089662:Doublecortin Protein; D005106:Exploratory Behavior; D005260:Female; D005638:Fruit / Q000737:chemistry; D006624:Hippocampus / Q000166:cytology / Q000378:metabolism / Q000473:pathology; D018551:Solanum lycopersicum / Q000737:chemistry*; D020935:MAP Kinase Signaling System; D008812:Mice, Hairless; D019636:Neurodegenerative Diseases / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D055495:Neurogenesis; D009474:Neurons / Q000166:cytology / Q000378:metabolism / Q000473:pathology; D018697:Nootropic Agents / Q000627:therapeutic use*; D010936:Plant Extracts / Q000627:therapeutic use*; D011897:Random Allocation; D021641:Recognition, Psychology; D015854:Up-Regulation
chemical_list: D015415:Biomarkers; D019208:Brain-Derived Neurotrophic Factor; C000714847:Dcx protein, mouse; D000089662:Doublecortin Protein; D018697:Nootropic Agents; D010936:Plant Extracts
keywords: aging; brain-derived neurotrophic factor; hippocampus; memory function; neurogenesis; tomato ethanolic extracts