title: Bispecific antibodies for viral immunotherapy.
abstract: Bispecific antibody engineering, in which binding specificities toward 2 distinct epitopes are combined into a single molecule, can greatly enhance immunotherapeutic properties of monoclonal antibodies. While the bispecific antibody approach has been applied widely to targets for indications such as cancer and inflammation, the development of such agents for viral immunotherapy is only now emerging. Here, we review recent advances in the development of bispecific antibodies for viral immunotherapy, highlighting promising in vitro and in vivo results.
authors: a Department of Biochemistry , Albert Einstein College of Medicine , Bronx , NY , USA.
authors: Elisabeth K
authors: EK
authors: Nyakatura
authors: a Department of Biochemistry , Albert Einstein College of Medicine , Bronx , NY , USA.
authors: Alexandra Y
authors: AY
authors: Soare
authors: a Department of Biochemistry , Albert Einstein College of Medicine , Bronx , NY , USA.
authors: Jonathan R
authors: JR
authors: Lai
mesh_terms: D000818:Animals; D018033:Antibodies, Bispecific / Q000008:administration & dosage / Q000276:immunology*; D000911:Antibodies, Monoclonal / Q000008:administration & dosage / Q000276:immunology*; D000914:Antibodies, Viral / Q000008:administration & dosage / Q000276:immunology*; D055808:Drug Discovery / Q000639:trends; D006801:Humans; D007155:Immunologic Factors / Q000008:administration & dosage / Q000276:immunology*; D007167:Immunotherapy / Q000379:methods*; D051379:Mice; D014777:Virus Diseases / Q000628:therapy*
chemical_list: D018033:Antibodies, Bispecific; D000911:Antibodies, Monoclonal; D000914:Antibodies, Viral; D007155:Immunologic Factors
keywords: antibody engineering; antibody therapeutics; antiviral; bifunctional antibodies; bispecific antibodies; immunotherapy; passive immunization; virology