title: Single-Center Case Series of Donor-Related Malignancies: Rare Cases With Tremendous Impact.
abstract: BACKGROUND
  Donor-related malignancy is a rare complication of organ transplantation.
  
  
  METHODS
  In this case series, we discuss three cases of donor-related cancers in kidney transplant recipients who were registered in our center between 1979 and 2015. They account for an incidence of 0.29% of donor-related malignancies of a total of 1015 transplanted kidney grafts (deceased and living donors). The three cases that we describe presented in different ways and with different severity, although the response to the initiated treatment was comparable.
  
  
  RESULTS
  All three patients not only survived their cancer episode but also had a complete oncological remission and underwent successful second kidney transplantation, accounting for a 100% survival rate in our small cohort.
  
  
  CONCLUSIONS
  Despite the very low incidence of this complication, transplant clinicians must be aware of the occurrence of donor-related malignancies when selecting a donor and should be able to diagnose and treat a case of donor-related cancer.
authors: Department of Nephrology, Antwerp University Hospital, Edegem, Belgium.
authors: L A
authors: LA
authors: Georgieva
authors: Department of Nephrology, Antwerp University Hospital, Edegem, Belgium; University of Antwerpen, Wilrijk, Belgium.
authors: E M
authors: EM
authors: Gielis
authors: Department of Nephrology, Antwerp University Hospital, Edegem, Belgium.
authors: R
authors: R
authors: Hellemans
authors: Department of Nephrology, Antwerp University Hospital, Edegem, Belgium; University of Antwerpen, Wilrijk, Belgium.
authors: A H
authors: AH
authors: Van Craenenbroeck
authors: Department of Nephrology, Antwerp University Hospital, Edegem, Belgium; University of Antwerpen, Wilrijk, Belgium.
authors: M M
authors: MM
authors: Couttenye
authors: Department of Nephrology, Antwerp University Hospital, Edegem, Belgium; University of Antwerpen, Wilrijk, Belgium.
authors: D
authors: D
authors: Abramowicz
authors: Department of Nephrology, Antwerp University Hospital, Edegem, Belgium.
authors: G
authors: G
authors: Van Beeumen
authors: Department of Pathology, Antwerp University Hospital, Edegem, Belgium.
authors: V
authors: V
authors: Siozopoulou
authors: Eurotransplant, Leiden, The Netherlands.
authors: M
authors: M
authors: Van Rosmalen
authors: Department of Hepatobiliary, Endocrine, and Transplantation Surgery, Antwerp University Hospital, Edegem, Belgium.
authors: B
authors: B
authors: Bracke
authors: Department of Hepatobiliary, Endocrine, and Transplantation Surgery, Antwerp University Hospital, Edegem, Belgium.
authors: V
authors: V
authors: Hartman
authors: University of Antwerpen, Wilrijk, Belgium; Department of Hepatobiliary, Endocrine, and Transplantation Surgery, Antwerp University Hospital, Edegem, Belgium.
authors: K
authors: K
authors: De Greef
authors: Department of Hepatobiliary, Endocrine, and Transplantation Surgery, Antwerp University Hospital, Edegem, Belgium.
authors: G
authors: G
authors: Roeyen
authors: Department of Hepatobiliary, Endocrine, and Transplantation Surgery, Antwerp University Hospital, Edegem, Belgium.
authors: T
authors: T
authors: Chapelle
authors: University of Antwerpen, Wilrijk, Belgium; Department of Hepatobiliary, Endocrine, and Transplantation Surgery, Antwerp University Hospital, Edegem, Belgium.
authors: D
authors: D
authors: Ysebaert
authors: Department of Nephrology, Antwerp University Hospital, Edegem, Belgium; University of Antwerpen, Wilrijk, Belgium. Electronic address: jean-louis.bosmans@uza.be.
authors: J L
authors: JL
authors: Bosmans
mesh_terms: D000328:Adult; D005260:Female; D006085:Graft Survival; D006801:Humans; D015994:Incidence; D007680:Kidney Neoplasms / Q000453:epidemiology / Q000209:etiology*; D016030:Kidney Transplantation / Q000401:mortality; D008297:Male; D008875:Middle Aged; D012086:Reoperation; D014019:Tissue Donors; D066027:Transplant Recipients