title: Post-translational modifications of FOXO family proteins (Review).
abstract: The Forkhead box O (FOXO) protein family is predominantly involved in apoptosis, oxidative stress, DNA damage/repair, tumor angiogenesis, glycometabolism, regulating life span and other important biological processes. Its activity is affected by a variety of posttranslational modifications (PTMs), including phosphorylation, acetylation, ubiquitination, methylation and glycosylation. When cells are subjected to different environments, the corresponding PTMs act on the FOXO protein family, to change transcriptional activity or subcellular localization, and the expression of downstream target genes, will ultimately affect the biological behavior of the cells. In this review, we will discuss the biological characteristics of FOXO protein PTMs.
authors: National Key Clinical Department, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400000, P.R. China.
authors: Ziyao
authors: Z
authors: Wang
authors: Chongqing Key Medical Laboratory of Obstetrics and Gynecology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing 400000, P.R. China.
authors: Tinghe
authors: T
authors: Yu
authors: National Key Clinical Department, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400000, P.R. China.
authors: Ping
authors: P
authors: Huang
mesh_terms: D000107:Acetylation; D000818:Animals; D051858:Forkhead Transcription Factors / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008745:Methylation; D005810:Multigene Family; D010766:Phosphorylation; D011499:Protein Processing, Post-Translational; D015398:Signal Transduction; D054875:Ubiquitination
chemical_list: D051858:Forkhead Transcription Factors