title: Necrotizing Infundibular Crystalline Folliculitis (NICF) Induced by Anti-Tumoral Therapies: Report of 2 Cases.
abstract: Necrotizing Infundibular Crystalline Folliculitis (NICF) is rare entity of unknown pathogenesis presenting as follicular crystalline papules arising in seborrheic areas. We report 2 cases of NICF in patients under targeted therapy for metastatic adenocarcinoma. In one case, the lesions reappeared cyclically every 3 weeks after each injection and in the other case, lesions persisted until disruption of the continuous oral therapy. Punch-biopsies demonstrated folliculitis with a plugging crystalline material associated with either bacteria or yeast. These are the first descriptions of drug-induced NICF.
authors: *Service de dermatologie, Hôpital Edouard Herriot, Lyon, France; †Service de pathologie, Hôpital Edouard Herriot, Lyon, France; ‡Département d'oncologie médicale, Centre Léon Bérard, Lyon, France; and §Département de Biopathologie, Centre Léon Bérard, Lyon, France.
authors: Kinda
authors: K
authors: Fattouh
authors: Diane
authors: D
authors: Collet-Benzaquen
authors: Anne M
authors: AM
authors: Provensal
authors: Françoise
authors: F
authors: Desseigne
authors: Christine
authors: C
authors: Castillo
authors: Patrick
authors: P
authors: Combemale
authors: Arnaud
authors: A
authors: de la Fouchardière
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy*; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000009:adverse effects*; D000068258:Bevacizumab / Q000008:administration & dosage / Q000009:adverse effects; D002166:Camptothecin / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives; D015179:Colorectal Neoplasms / Q000188:drug therapy; D003875:Drug Eruptions / Q000209:etiology* / Q000473:pathology; D000069347:Erlotinib Hydrochloride / Q000009:adverse effects; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects; D005499:Folliculitis / Q000139:chemically induced*; D006801:Humans; D000077146:Irinotecan; D008175:Lung Neoplasms / Q000188:drug therapy; D008297:Male
chemical_list: D000970:Antineoplastic Agents; D000068258:Bevacizumab; D000077146:Irinotecan; D000069347:Erlotinib Hydrochloride; D005472:Fluorouracil; D002166:Camptothecin