title: Differential role of intravenous anesthetics in colorectal cancer progression: implications for clinical application.
abstract: Anesthetics are unavoidable to colorectal cancer (CRC) patients who underwent surgical treatment. Thus, the molecular mechanisms underlying the role of the intravenous anesthetics in CRC metastasis are still unclear. In this study, the effects of intravenous anesthetics, such as propofol, etomidate and dexmedetomidine, on cell migration were determined. The migration of CRC cells was inhibited by propofol in vitro, but not in vivo. Etomidate, however, promoted the migration of CRC cells both in vitro and in vivo. Epithelial-mesenchymal transition (EMT) mediated the promotive effect of propofol and etomidate on the migration of CRC cells through PI3K/AKT signaling pathway. Dexmedetomidine alone or in combination with propofol or etomidate had minor effect on the migration of CRC cells. These findings indicate that propofol inhibites CRC cell migration in vitro. Etomidate playes a role for prompting CRC metastasis progression by activating (PI3K)/AKT signaling and inducing EMT. It provides an important hint for the clinical application of these anesthetics.
authors: Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.|Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China.
authors: Fengliu
authors: F
authors: Deng
authors: Department of anesthesia, Fifth Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong, China.
authors: Mingwen
authors: M
authors: Ouyang
authors: Department of Anesthesia, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
authors: Xiaofei
authors: X
authors: Wang
authors: Department of General Surgery, Guangdong General Hospital, Guangdong Academy of Medical Science, Guangzhou, Guangdong, China.
authors: Xueqing
authors: X
authors: Yao
authors: Department of Anesthesia, Huarui Hospital, Southern Medical University, Guangzhou, Guangdong, China.
authors: Yeming
authors: Y
authors: Chen
authors: Department of Anesthesia, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
authors: Tao
authors: T
authors: Tao
authors: The Key Laboratory of Molecular Biology, State Administration of Traditional Chinese Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, China.
authors: Xuegang
authors: X
authors: Sun
authors: Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.|Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China.
authors: Lijun
authors: L
authors: Xu
authors: Department of Anesthesia, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
authors: Jing
authors: J
authors: Tang
authors: Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.|Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China.
authors: Liang
authors: L
authors: Zhao
mesh_terms: D018686:Anesthetics, Intravenous / Q000008:administration & dosage* / Q000009:adverse effects; D000818:Animals; D045744:Cell Line, Tumor; D002465:Cell Movement; D015179:Colorectal Neoplasms / Q000378:metabolism / Q000473:pathology / Q000601:surgery*; D020927:Dexmedetomidine / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology; D018450:Disease Progression; D058750:Epithelial-Mesenchymal Transition; D005045:Etomidate / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D045325:HCT116 Cells; D006801:Humans; D051379:Mice; D009362:Neoplasm Metastasis; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D011379:Prognosis; D015742:Propofol / Q000008:administration & dosage* / Q000009:adverse effects; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D018686:Anesthetics, Intravenous; D020927:Dexmedetomidine; D019869:Phosphatidylinositol 3-Kinases; D051057:Proto-Oncogene Proteins c-akt; D015742:Propofol; D005045:Etomidate
keywords: colorectal cancer; dexmedetomidine; epithelial-mesenchymal transition; etomidate; propofol