title: [Gut microbiome and major depressive disorder : The other side of ourselves].
abstract: Microbiological ecology and its ambition to describe the complete genome of complex living communities as a whole, have given us powerful tools to characterize the human gut microbiome on a genetic and, hence, taxonomic and abundance level; for a decade now, they have become sufficiently inexpensive, fast and feasible. Thus, opportunities arose to have a fresh and closer look at the microbiota-gut-brain-axis and its impact on human health; this axis comprises a complex multisystemic network of multidirectional interactions between brain and gut including influences beyond one generation. Gnotobiotic animal models have become essential for specific research targets. Combining gut microbiome analysis with observations on the hypothalamus-pituitary-adrenal axis and various aspects of inflammation helped to gain first insights into the role of the microbiota-gut-brain-axis in depressive disorders. Therapeutic endeavors with psychobiotics have not yet shown their value in clinical studies.
authors: Klinik und Poliklinik für Psychiatrie und Psychotherapie, Universität Regensburg, Universitätsstraße 84, 93053, Regensburg, Deutschland.
authors: A
authors: A
authors: Manook
authors: Institut für Klinische Mikrobiologie und Hygiene, Universität Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Deutschland.
authors: A
authors: A
authors: Hiergeist
authors: Klinik und Poliklinik für Psychiatrie und Psychotherapie, Universität Regensburg, Universitätsstraße 84, 93053, Regensburg, Deutschland.
authors: R
authors: R
authors: Rupprecht
authors: Klinik und Poliklinik für Psychiatrie und Psychotherapie, Universität Regensburg, Universitätsstraße 84, 93053, Regensburg, Deutschland. thomas.baghai@medbo.de.
authors: T C
authors: TC
authors: Baghai
mesh_terms: D003865:Major Depressive Disorder / Q000382:microbiology* / Q000503:physiopathology*; D000069196:Gastrointestinal Microbiome / Q000502:physiology*; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000382:microbiology / Q000503:physiopathology*; D008954:Models, Biological; D010913:Pituitary-Adrenal System / Q000382:microbiology* / Q000503:physiopathology*
keywords: Functional imaging; Hypothalamo-hypophyseal system; Microbiota-gut-brain-axis; Psychobiotics; Translational metagenomics