title: Platelet activation and function in response to high intensity interval exercise and moderate continuous exercise in CABG and PCI patients.
abstract: BACKGROUND
  The effects of high intensity interval training (HIIT) on inflammatory markers and endothelial function have been extensively shown. However, the acute effect of HIIT on platelet activation and function in patients with recent revascularization is unclear.
  
  
  OBJECTIVE
  The purpose of present study was to compare the responses of platelet activation (CD62P) and function (platelet aggregation) to high intensity interval exercise (HIIE) and moderate continuous exercise (MCE) in coronary artery bypass grafting (CABG) and percutaneous coronary interventions (PCI) patients.
  
  
  METHODS
  Thirty patients who had CABG or PCI were randomly divided into HIIE, MCE and control groups. After determining the VO2peak, subjects in the MCE group carried out 30 min of continuous exercise at 60% of VO2peak, whereas, the subjects in HIIE group performed an interval protocol consisted of 8 repetitions of 2 min activity (running on treadmill) at 90% of VO2peak interspersed by 2 min of active recovery between repetitions at 30% of VO2peak .  Subjects in control group were seated and had no activity for the same period of time. Two blood samples were collected before and immediately after exercise and were analyzed for markers of platelet activation and function.
  
  
  RESULTS
  Data analyzes revealed that increases in platelet aggregation induced by ADP and corrected for increases in platelet count in response to MCE trial was significantly lower than HIIE group (P < 0.05). In addition, responses of CD62P to MCE trial was significantly lower compared to HIIE group (P < 0.05). Changes in plateletcrit and platelet distribution width were significantly different among the three trials where the PCT and PDW following the HIIE were higher than MCE. Platelet count increased significantly (P < 0.05) by 13% following HIIE trial.
  
  
  CONCLUSIONS
  Based on the findings of the present study it could be concluded that the risk of exercise-induced thrombosis is higher during HIIE than MCE in patients with recent revascularization.
authors: Department of Sport and Exercise Physiology, Faculty of Sports Sciences, Shahid Beheshti University, Tehran, Iran.
authors: Sajad
authors: S
authors: Ahmadizad
authors: Department of Sport and Exercise Physiology, Faculty of Sports Sciences, Shahid Beheshti University, Tehran, Iran.
authors: Akbar
authors: A
authors: Nouri-Habashi
authors: Department of Sport and Exercise Physiology, Faculty of Sports Sciences, Shahid Beheshti University, Tehran, Iran.
authors: Hiwa
authors: H
authors: Rahmani
authors: Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.
authors: Majid
authors: M
authors: Maleki
authors: Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.
authors: Nasim
authors: N
authors: Naderi
authors: Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.
authors: Sara
authors: S
authors: Lotfian
authors: Platelet Research Laboratory, Kashan University of Medical Sciences, Kashan, Iran.
authors: Morteza
authors: M
authors: Salimian
mesh_terms: D001026:Coronary Artery Bypass / Q000379:methods*; D015444:Exercise / Q000502:physiology*; D005260:Female; D000072696:High-Intensity Interval Training / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D062645:Percutaneous Coronary Intervention / Q000379:methods*; D015539:Platelet Activation / Q000502:physiology*
keywords: CD62P; Interval exercise; acute exercise; p-selectin; platelet aggregation