title: NMR reassignment of stictic acid isolated from a Sumatran lichen Stereocaulon montagneanum (Stereocaulaceae) with superoxide anion scavenging activities.
abstract: The phytochemical study of Stereocaulon montagneanum harvested in Sumatra (Indonesia) led to the isolation of 11 known compounds including two metabolites not previously described in the genus Stereocaulon, peristictic acid (8) and menegazziaic acid (10). The complete 1H and 13C NMR spectral assignments of stictic acid derivatives are reported with some revisions. Five depsidones belonging to the stictic acid chemosyndrome were superoxide anion scavengers as potent as ascorbic acid and with no toxicity on two human cell lines.
authors: The Laboratory of Natural Resource of Sumatra (LBS) and Faculty of Pharmacy, Andalas University, 26163 Padang, Indonesia.
authors: Friardi
authors: F
authors: Ismed
authors: UMR-CNRS 6226 ISCR, Equipe PNSCM, Faculté des Sciences Pharmaceutiques et Biologiques, Université de Rennes 1, 35043 Rennes Cedex, France.
authors: Françoise Lohézic-Le
authors: FL
authors: Dévéhat
authors: UMR-CNRS 6226 ISCR, Equipe PNSCM, Faculté des Sciences Pharmaceutiques et Biologiques, Université de Rennes 1, 35043 Rennes Cedex, France.
authors: Isabelle
authors: I
authors: Rouaud
authors: UMR-CNRS 6226 ISCR, Equipe PNSCM, Faculté des Sciences Pharmaceutiques et Biologiques, Université de Rennes 1, 35043 Rennes Cedex, France.
authors: Solenn
authors: S
authors: Ferron
authors: The Laboratory of Natural Resource of Sumatra (LBS) and Faculty of Pharmacy, Andalas University, 26163 Padang, Indonesia.
authors: Amri
authors: A
authors: Bakhtiar
authors: UMR-CNRS 6226 ISCR, Equipe PNSCM, Faculté des Sciences Pharmaceutiques et Biologiques, Université de Rennes 1, 35043 Rennes Cedex, France.
authors: Joël
authors: J
authors: Boustie
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002460:Cell Line; D004353:Drug Evaluation, Preclinical; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D007214:Indonesia; D015603:Keratinocytes / Q000187:drug effects / Q000528:radiation effects; D008011:Lichens / Q000737:chemistry*; D008546:Melanoma, Experimental; D051379:Mice; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010082:Oxepins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D011837:Radiation-Protective Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D012997:Solvents; D013481:Superoxides / Q000378:metabolism*; D014466:Ultraviolet Rays
chemical_list: D000975:Antioxidants; D016166:Free Radical Scavengers; D006576:Heterocyclic Compounds, 4 or More Rings; D010082:Oxepins; D011837:Radiation-Protective Agents; D012997:Solvents; C522101:stictic acid; D013481:Superoxides