title: Ophthalmologic Findings in Children with Leukemia: A Single-Center Study.
abstract: OBJECTIVE
  Ophthalmologic disease in patients with acute leukemia occurs due to primary leukemic infiltration (involvement), or secondary to the disease and its treatment. In recent years the life expectancy of acute leukemia patients has increased with the advent of modern therapies. The present study aimed to determine the incidence of ocular manifestations in children with acute leukemia.
  
  
  METHODS
  The study included 120 patients diagnosed with acute leukemia at Başkent University Hospital, Pediatric Hematology Department between 1995 and 2010. All the patients were examined by an ophthalmologist via direct and indirect ophthalmoscopy.
  
  
  RESULTS
  Among the patients, 83 (69.2%) were diagnosed with acute lymphoblastic leukemia, 35 (29.1%) with acute myeloblastic leukemia, and 2 (1.7%) with mixed-lineage leukemia. In all, 58 ophthalmic manifestations were noted in 41 patients (34.2%). In our patients, 12 ophthalmologic involvements were present at admission and 46 ocular findings occurred during follow-up. The incidence of these manifestations increased with age.
  
  
  CONCLUSIONS
  Ophthalmologic manifestations were not correlated with gender, hematological parameters at disease onset, type of leukemia, or the frequency of relapse and survival. To more clearly determine the effect of ophthalmologic manifestations on the prognosis of leukemia, larger scale and multi-center studies are needed.
authors: Başkent University Faculty of Medicine, Department of Pediatrics, Ankara, Turkey.
authors: Betül
authors: B
authors: Orhan
authors: Başkent University Faculty of Medicine, Department of Pediatric Hematology, Ankara, Turkey.
authors: Barış
authors: B
authors: Malbora
authors: Başkent University Faculty of Medicine, Department of Ophthalmology, Ankara, Turkey.
authors: Sezin
authors: S
authors: Akça Bayar
authors: Başkent University Faculty of Medicine, Department of Pediatric Hematology, Ankara, Turkey.
authors: Zekai
authors: Z
authors: Avcı
authors: Başkent University Faculty of Medicine, Department of Pediatric Hematology, Ankara, Turkey.
authors: Bülent
authors: B
authors: Alioğlu
authors: Başkent University Faculty of Medicine, Department of Pediatric Hematology, Ankara, Turkey.
authors: Namık
authors: N
authors: Özbek
keywords: Leukemia; children; ophthalmologic findings