title: Psoriasis increases risk of new-onset atrial fibrillation: a systematic review and meta-analysis of prospective observational studies.
abstract: BACKGROUND
  Psoriasis is a common chronic immune-mediated dermatological disease that increases the risk of cardiovascular disease. We conducted a systematic review and meta-analysis to evaluate the association between psoriasis and atrial fibrillation from prospective observational studies.
  
  
  METHODS
  A comprehensive search of the databases of the MEDLINE and EMBASE was performed from inception through November 2015. The inclusion criterion was the prospective observational study that assessed the risk of new-onset atrial fibrillation in adults with psoriasis. Outcome was the adjusted hazard ratio (HR) of atrial fibrillation comparison between patients with psoriasis and controls. Pooled HR and 95% confidence intervals (CI) were calculated using a random-effects model.
  
  
  RESULTS
  The initial search yielded 176 articles. Fifteen articles underwent full-length review and data were extracted from 4 observational studies. Incidence of atrial fibrillation was ascertained by cardiologist-reviewed electrocardiograms. There was a significant increased risk of new-onset atrial fibrillation in patients with psoriasis compared to controls with a pooled HR 1.42 (95%CI 1.22-1.65).
  
  
  CONCLUSIONS
  Our meta-analysis of prospective studies demonstrated that patients with psoriasis have increased risk of new-onset atrial fibrillation. Future interventional studies addressing the impact of psoriasis treatment and prevention of atrial fibrillation should be performed.
authors: a Department of Internal Medicine , Bassett Medical Center and Columbia University College of Physicians and Surgeons , Cooperstown , NY , USA.|b Department of Preventive and Social Medicine, Faculty of Medicine Siriraj Hospital , Mahidol University , Bangkok, Thailand.
authors: Sikarin
authors: S
authors: Upala
authors: a Department of Internal Medicine , Bassett Medical Center and Columbia University College of Physicians and Surgeons , Cooperstown , NY , USA.
authors: Afeefa
authors: A
authors: Shahnawaz
authors: a Department of Internal Medicine , Bassett Medical Center and Columbia University College of Physicians and Surgeons , Cooperstown , NY , USA.|b Department of Preventive and Social Medicine, Faculty of Medicine Siriraj Hospital , Mahidol University , Bangkok, Thailand.
authors: Anawin
authors: A
authors: Sanguankeo
mesh_terms: D001281:Atrial Fibrillation / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology; D016208:Databases, Factual; D004562:Electrocardiography; D006801:Humans; D015994:Incidence; D016016:Proportional Hazards Models; D011446:Prospective Studies; D011565:Psoriasis / Q000150:complications / Q000473:pathology*; D012306:Risk
keywords: Psoriasis; atrial fibrillation; meta-analysis