title: Circulating MicroRNAs as Potential Biomarkers of Exercise Response.
abstract: Systematic physical activity increases physical ﬁtness and exercise capacity that lead to the improvement of health status and athletic performance. Considerable effort is devoted to identifying new biomarkers capable of evaluating exercise performance capacity and progress in training, early detection of overtraining, and monitoring health-related adaptation changes. Recent advances in OMICS technologies have opened new opportunities in the detection of genetic, epigenetic and transcriptomic biomarkers. Very promising are mainly small non-coding microRNAs (miRNAs). miRNAs post-transcriptionally regulate gene expression by binding to mRNA and causing its degradation or inhibiting translation. A growing body of evidence suggests that miRNAs affect many processes and play a crucial role not only in cell differentiation, proliferation and apoptosis, but also affect extracellular matrix composition and maintaining processes of homeostasis. A number of studies have shown changes in distribution proﬁles of circulating miRNAs (c-miRNAs) associated with various diseases and disorders as well as in samples taken under physiological conditions such as pregnancy or physical exercise. This overview aims to summarize the current knowledge related to the response of blood c-miRNAs proﬁles to different modes of exercise and to highlight their potential application as a novel class of biomarkers of physical performance capacity and training adaptation.
authors: Hamar Institute for Human Performance, Faculty of Physical Education and Sports, Comenius University Bratislava, Nábr. Arm. Gen. L. Svobodu 9, Bratislava 814 69, Slovakia. maja.polakovicova@uniba.sk.
authors: Mája
authors: M
authors: Polakovičová
authors: Department of Pharmacology and Toxicology, Faculty of Pharmacy, Comenius University Bratislava, Odbojárov 10, Bratislava 832 32, Slovakia. peter.musil@uniba.sk.
authors: Peter
authors: P
authors: Musil
authors: Department of Track & Field, Faculty of Physical Education and Sports, Comenius University Bratislava, Nábr. Arm. Gen. L. Svobodu 9, Bratislava 814 69, Slovakia. eugen.laczo@uniba.sk.
authors: Eugen
authors: E
authors: Laczo
authors: Department of Sport Kinanthropology, Faculty of Physical Education and Sports, Comenius University Bratislava, Nábr. Arm. Gen. L. Svobodu 9, Bratislava 814 69, Slovakia. dusan.hamar@uniba.sk.
authors: Dušan
authors: D
authors: Hamar
authors: Department of Pharmacology and Toxicology, Faculty of Pharmacy, Comenius University Bratislava, Odbojárov 10, Bratislava 832 32, Slovakia. kyselovic@uniba.sk.
authors: Ján
authors: J
authors: Kyselovič
mesh_terms: D015415:Biomarkers / Q000097:blood*; D015444:Exercise; D006801:Humans; D035683:MicroRNAs / Q000097:blood* / Q000235:genetics / Q000378:metabolism; D018482:Muscle, Skeletal / Q000378:metabolism
chemical_list: D015415:Biomarkers; D035683:MicroRNAs
keywords: biomarker; circulating microRNA; physical exercise; skeletal muscle