title: Antiproliferative effect of synthetic cyclic imides (methylphtalimides, carboxylic acid phtalimides and itaconimides) against human cancer cell lines.
abstract: This work describes the antiproliferative potential of 14 cyclic imides (methylphtalimides, carboxylic acid phtalimides and itaconimides) against several human cancer cell lines. The antiproliferative effect was evaluated using the sulforhodamine B assay. Although some compounds from methylphtalimide and carboxylic acid phtalimide classes exhibited a selective antiproliferative activity, the itaconimides (11-14) exhibited the best results, especially compound 14, which presented a TGI (concentration that produces total growth inhibition) value of 0.0043 μM against glioma (U251), being inactive against the non-tumor cell line (HaCat). Absorption, distribution, metabolism and excretion in silico evaluations suggest that these compounds are promising candidates.
authors: Dorimar
authors: D
authors: Stiz
authors: Adriana
authors: A
authors: Campos
authors: Ana
authors: A
authors: Lúcia Tasca Gois Ruiz
authors: João
authors: J
authors: Ernesto de Carvalho
authors: Rogério
authors: R
authors: Corrêa
authors: Valdir
authors: V
authors: Cechinel-Filho
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D003500:Cyclization; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007094:Imides / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D007094:Imides