title: Self-Targeted Polysaccharide Prodrug Suppresses Orthotopic Hepatoma.
abstract: Self-targetability is an emerging targeting strategy for polymer nanocarriers with facile preparation and high targeting efficiency. An acid-sensitive dextran-doxorubicin prodrug (Dex-g-DOX) has been synthesized and used as a self-targeted drug delivery system for the treatment of orthotopic hepatoma. The polysaccharide prodrug exhibits ultraselective accumulation in cancerous liver tissue, acid-sensitive DOX release within cells, and high antitumor efficacy in vitro and in vivo. Therefore, Dex-g-DOX demonstrates great potential for chemotherapy of orthotopic hepatoma.
authors: Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , Changchun 130022, P. R. China.|Department of Chemistry, Northeast Normal University , Changchun 130024, P. R. China.
authors: Di
authors: D
authors: Li
authors: Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , Changchun 130022, P. R. China.
authors: Weiguo
authors: W
authors: Xu
authors: Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , Changchun 130022, P. R. China.
authors: Pengqiang
authors: P
authors: Li
authors: Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , Changchun 130022, P. R. China.
authors: Jianxun
authors: J
authors: Ding
authors: Department of Bioengineering, University of Pennsylvania , Philadelphia, Pennsylvania 19104-6321, United States.
authors: Zhiliang
authors: Z
authors: Cheng
authors: Department of Chemistry, Northeast Normal University , Changchun 130024, P. R. China.
authors: Li
authors: L
authors: Chen
authors: Department of Bioengineering, University of Pennsylvania , Philadelphia, Pennsylvania 19104-6321, United States.
authors: Lesan
authors: L
authors: Yan
authors: Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , Changchun 130022, P. R. China.
authors: Xuesi
authors: X
authors: Chen
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology; D006528:Carcinoma, Hepatocellular / Q000517:prevention & control*; D002470:Cell Survival / Q000187:drug effects; D003911:Dextrans / Q000008:administration & dosage / Q000737:chemistry*; D004317:Doxorubicin / Q000494:pharmacology*; D016503:Drug Delivery Systems; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008113:Liver Neoplasms / Q000517:prevention & control*; D051379:Mice; D008807:Mice, Inbred BALB C; D011355:Prodrugs / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
chemical_list: D000903:Antibiotics, Antineoplastic; D003911:Dextrans; D011355:Prodrugs; D004317:Doxorubicin
keywords: chemotherapy; orthotopic hepatoma; polysaccharide; prodrug; self-targetability