title: Frequency of the Paradoxical Effect Measured Using the EUCAST Procedure with Micafungin, Anidulafungin, and Caspofungin against Candida Species Isolates Causing Candidemia.
abstract: We report data on the frequency of the paradoxical effect of echinocandins against Candida spp. (n = 602 incident isolates) using the EUCAST definitive document EDef 7.2 procedure. The paradoxical effect for one or more echinocandins was observed in 16% of the isolates. However, differences between species were found, and the paradoxical effect was more common in Candida tropicalis (P < 0.001). Caspofungin was the drug in which the paradoxical effect was most common, followed by anidulafungin and micafungin (P < 0.001).
authors: Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain.|Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.
authors: Laura Judith
authors: LJ
authors: Marcos-Zambrano
authors: Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain.|Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.
authors: Pilar
authors: P
authors: Escribano
authors: Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain.|Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.|CIBER Enfermedades Respiratorias-CIBERES (CB06/06/0058), Madrid, Spain.
authors: Carlos
authors: C
authors: Sánchez-Carrillo
authors: Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain.|Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.|CIBER Enfermedades Respiratorias-CIBERES (CB06/06/0058), Madrid, Spain.|Medicine Department, School of Medicine, Universidad Complutense de Madrid, Madrid, Spain.
authors: Emilio
authors: E
authors: Bouza
authors: Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain jguineaortega@yahoo.es.|Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.|CIBER Enfermedades Respiratorias-CIBERES (CB06/06/0058), Madrid, Spain.|Medicine Department, School of Medicine, Universidad Complutense de Madrid, Madrid, Spain.
authors: Jesús
authors: 0000-0002-7901-8355
authors: J
authors: Guinea
mesh_terms: D000077612:Anidulafungin; D000935:Antifungal Agents / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects*; D041022:Candida tropicalis / Q000187:drug effects; D058387:Candidemia / Q000382:microbiology; D002177:Candidiasis / Q000382:microbiology; D000077336:Caspofungin; D054714:Echinocandins / Q000494:pharmacology*; D055666:Lipopeptides / Q000494:pharmacology*; D000077551:Micafungin; D008826:Microbial Sensitivity Tests
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D000077612:Anidulafungin; D000077336:Caspofungin; D000077551:Micafungin
keywords: Candida; EUCAST; echinocandins; paradoxical effect