title: The effects of nanotopography and coculture systems to promote angiogenesis for wound repair.
abstract: Insufficient angiogenesis in severe wounds delays wound repair because of a lack of blood supply to the wound site. Therefore, pro-angiogenic therapeutics may enhance wound repair. Many studies have investigated various physical and biochemical cues to improve angiogenesis, such as biocompatible materials, surface modifications, angiogenic factors and coculture systems using various cell types. However, the present capability to mimic the micro- and nanostructure of the natural microenvironment, particularly its porous, fibrous features, is limited. Nanotopography may represent a promising tool to overcome these limitations. Here, we discuss various approaches to the use of nanotopography to enhance angiogenesis and consider the combination of coculture systems with nanotopography to mimic the native environment for promotion of angiogenesis in wound healing and repair.
authors: Biomaterials Research Center, Korea Institute of Science & Technology, 5, Hwanrangno 14 Gil, Seoungbuk-gu, Seoul 02792, Republic of Korea.|KU-KIST Graduate School of Converging Science & Technology, Korea University, Anam-ro, Seongbuk-gu, Seoul 02841, Republic of Korea.
authors: Tae Hee
authors: TH
authors: Kim
authors: Biomaterials Research Center, Korea Institute of Science & Technology, 5, Hwanrangno 14 Gil, Seoungbuk-gu, Seoul 02792, Republic of Korea.|KU-KIST Graduate School of Converging Science & Technology, Korea University, Anam-ro, Seongbuk-gu, Seoul 02841, Republic of Korea.|Department of Biomedical Engineering, Korea University of Science & Technology, Hwanrangno 14 Gil, Seoungbuk-gu, Seoul 02792, Republic of Korea.
authors: Soo Hyun
authors: SH
authors: Kim
authors: Biomaterials Research Center, Korea Institute of Science & Technology, 5, Hwanrangno 14 Gil, Seoungbuk-gu, Seoul 02792, Republic of Korea.|Department of Biomedical Engineering, Korea University of Science & Technology, Hwanrangno 14 Gil, Seoungbuk-gu, Seoul 02792, Republic of Korea.
authors: Youngmee
authors: Y
authors: Jung
mesh_terms: D001672:Biocompatible Materials / Q000008:administration & dosage* / Q000737:chemistry; D060833:Cellular Microenvironment / Q000187:drug effects; D018920:Coculture Techniques; D006801:Humans; D049329:Nanostructures / Q000008:administration & dosage* / Q000737:chemistry; D036103:Nanotechnology / Q000379:methods; D018919:Neovascularization, Physiologic / Q000187:drug effects*; D012867:Skin / Q000098:blood supply / Q000187:drug effects* / Q000503:physiopathology; D014945:Wound Healing / Q000187:drug effects
chemical_list: D001672:Biocompatible Materials
keywords: angiogenesis; coculture system; endothelial cells; nanotopography; pericyte