title: [Imbalance of Tc and Th in Peripheral Blood of Patients with Systemic Lupus Erythematosus and Its Significance].
abstract: OBJECTIVE
  To investigate the imbalance of Tc1/Tc2,Th1/Th2 and Tc/Th in patients with systemic lupus erythematosus(SLE) and its relationship with the clinical stages of SLE.
  
  
  METHODS
  The full blood culture and flow cytometry with fluorescence-labelled T lymphocytes were used to detect the levels of T-lymphocyte subsets and its intracellular factors IFN-γ and IL-4 in peripheral blood from SLP patients in active, inactive stages and normal healthy persons as controls, to compare the changes of Tc1,Tc2; Th1,Th2 levels and Tc/Th ratio in SLP patients in active and inactive stages, and to analyze their relationship with SLEDAI staging.
  
  
  RESULTS
  Compared with healthy controls, the levels of CD4+/CD8+in active SLE patients were significantly lower, but the levels of Tc1,Th1 in active SLE patients were higher than those in inactive SLE patients and normal controls. The ratio of Tc1/Tc2 and Th1/Th2 in the active SLE was higher than that in inactive SLE and normal controls(P<0.05), but the difference between inactive SLE patients and controls was not statistically significant (P>0.05).
  
  
  CONCLUSIONS
  The Tc/Th imbalances and change of Tc and Th cells to Tc1 and Th1 cells play an important role in the pathogenesis of SLE.
authors: Department of Hematology, Rheumatology and Immunology, The Xuzhou Municiple First People's Hospital, Xuzhou 221002, Jiangsu Province,China.
authors: Wei-Jun
authors: WJ
authors: Gu
authors: Department of Hematology, Rheumatology and Immunology, The Xuzhou Municiple First People's Hospital, Xuzhou 221002, Jiangsu Province,China.
authors: Qing-Guo
authors: QG
authors: Zhang
authors: Department of Hematology, Rheumatology and Immunology, The Xuzhou Municiple First People's Hospital, Xuzhou 221002, Jiangsu Province,China.
authors: Wei
authors: W
authors: Zhu
authors: Department of Hematology, Rheumatology and Immunology, The Xuzhou Municiple First People's Hospital, Xuzhou 221002, Jiangsu Province,China.
authors: Yu-Lin
authors: YL
authors: Guo
authors: Department of Hematology, Rheumatology and Immunology, The Xuzhou Municiple First People's Hospital, Xuzhou 221002, Jiangsu Province,China. E-mail:qq102367@163.com.
authors: Lu-Qin
authors: LQ
authors: Zhang
mesh_terms: D005434:Flow Cytometry; D006801:Humans; D015847:Interleukin-4; D008180:Lupus Erythematosus, Systemic; D018655:Lymphocyte Count; D016176:T-Lymphocyte Subsets; D006377:T-Lymphocytes, Helper-Inducer
chemical_list: D015847:Interleukin-4