title: Novel association between bone mineral density scores and the prevalence of peripheral artery disease in both sexes.
abstract: The purpose of the current study was to investigate the association between bone mineral density (BMD) scores and the prevalence of peripheral artery disease (PAD) in a large cohort of subjects who underwent arterial Doppler assessments and calcaneal bone densitometry. The study was performed using data obtained from Life Line Screening Inc. Subjects were self-selected and paid for screening tests. The prevalence of PAD was significantly higher in men with osteopenia (4.5%) and osteoporosis (10.9%) compared to men with normal BMD (3.0%) ( p<0.001). Osteopenia (odds ratio (OR) 1.3) and osteoporosis (OR 2.3) were found to be independent risk factors for the presence of PAD in men. The prevalence of PAD was significantly higher in women with osteopenia (4.8%) and osteoporosis (11.8%) compared to women with normal BMD (3.3%) ( p<0.001). Osteopenia (OR 1.15) and osteoporosis (OR 1.8) were found to be independent risk factors for the presence of PAD in women. The current study reports a strong association of abnormal BMD analysis with the prevalence of PAD, which persists even when controlling for age and associated atherosclerotic risk factors. Although the mechanism by which these two disease processes is related is not completely elucidated, the presence of osteoporosis should make clinicians aware of the possibility of occult PAD or associated atherosclerotic disease in appropriate patients.
authors: 1 Division of Vascular & Endovascular Surgery, New York University Langone Medical Center, New York, NY, USA.
authors: Melissa J
authors: MJ
authors: Baldwin
authors: 1 Division of Vascular & Endovascular Surgery, New York University Langone Medical Center, New York, NY, USA.
authors: Aleksandra
authors: A
authors: Policha
authors: 1 Division of Vascular & Endovascular Surgery, New York University Langone Medical Center, New York, NY, USA.
authors: Thomas
authors: T
authors: Maldonado
authors: 2 Division of Vascular & Endovascular Surgery, University of California San Francisco Medical Center, San Francisco, CA, USA.
authors: Jade S
authors: JS
authors: Hiramoto
authors: 1 Division of Vascular & Endovascular Surgery, New York University Langone Medical Center, New York, NY, USA.
authors: Stephen
authors: S
authors: Honig
authors: 2 Division of Vascular & Endovascular Surgery, University of California San Francisco Medical Center, San Francisco, CA, USA.
authors: Michael S
authors: MS
authors: Conte
authors: 1 Division of Vascular & Endovascular Surgery, New York University Langone Medical Center, New York, NY, USA.
authors: Jeffrey
authors: J
authors: Berger
authors: 1 Division of Vascular & Endovascular Surgery, New York University Langone Medical Center, New York, NY, USA.
authors: Caron B
authors: CB
authors: Rockman
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D055109:Ankle Brachial Index; D015519:Bone Density; D001851:Bone Diseases, Metabolic / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000503:physiopathology; D016009:Chi-Square Distribution; D015897:Comorbidity; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D010024:Osteoporosis / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000503:physiopathology; D058729:Peripheral Arterial Disease / Q000175:diagnosis / Q000453:epidemiology*; D015995:Prevalence; D012307:Risk Factors; D017678:Sex Distribution; D014463:Ultrasonography; D014481:United States / Q000453:epidemiology
keywords: atherosclerosis; bone mineral density; osteoporosis; ostopenia; peripheral artery disease (PAD)