title: The mechanistic role of antibodies to dengue virus in protection and disease pathogenesis.
abstract: Dengue is a prevalent disease in tropical and subtropical countries with an estimated 400 million people infected annually. While significant advancement has been made in the chase for an effective dengue vaccine, the recently licensed Sanofi vaccine was, in contrast to in vitro data, only partially protective. Areas covered: This suggests that our understanding of the serological correlates for dengue is currently inadequate. With growing evidence supporting the role of fragment crystalizable gamma receptors (FcγRs) in antibody-mediated neutralization or antibody-dependent enhancement (ADE) of dengue virus (DENV) infection, FcγR-expressing cells have been increasingly used for measuring neutralizing antibody responses elicited by dengue vaccines. Here, we review the mechanisms of how FcγRs modulates both DENV neutralization and enhanced infections via its interactions with antibodies. Expert commentary: This review provides insights on the importance of factoring FcγRs for in vitro neutralization assays. Bridging the gap between in vitro and clinical observations would allow researchers to more accurately predict in vivo vaccine efficacy.
authors: a Program in Emerging Infectious Diseases , Duke-NUS Medical School , Singapore , Singapore.
authors: Esther Shuyi
authors: ES
authors: Gan
authors: b Department of Microbiology and Immunology, Yong Loo Lin School of Medicine , National University of Singapore , Singapore , Singapore.
authors: Donald Heng Rong
authors: DH
authors: Ting
authors: a Program in Emerging Infectious Diseases , Duke-NUS Medical School , Singapore , Singapore.
authors: Kuan Rong
authors: KR
authors: Chan
mesh_terms: D057134:Antibodies, Neutralizing / Q000276:immunology; D000914:Antibodies, Viral / Q000276:immunology* / Q000378:metabolism; D019067:Antibody-Dependent Enhancement / Q000276:immunology*; D003715:Dengue / Q000276:immunology* / Q000517:prevention & control; D053059:Dengue Vaccines / Q000276:immunology; D003716:Dengue Virus / Q000276:immunology*; D006801:Humans; D017452:Receptors, IgG / Q000235:genetics / Q000378:metabolism*
chemical_list: D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral; D053059:Dengue Vaccines; D017452:Receptors, IgG
keywords: Dengue virus; FcγR; antibody; antibody-dependent enhancement; dengue vaccine; immune correlates; neutralization