title: Transforming Growth Factor β Superfamily Signaling in Development of Colorectal Cancer.
abstract: Transforming growth factor (TGF)-β cytokines signal via a complex network of pathways to regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types. A high percentage of colorectal tumors contain mutations that disrupt TGF-β family member signaling. We review how TGF-β family member signaling is altered during development of colorectal cancer, models of study, interaction of pathways, and potential therapeutic strategies.
authors: University of Illinois at Chicago, Chicago, Illinois. Electronic address: bjung@uic.edu.
authors: Barbara
authors: B
authors: Jung
authors: University of Illinois at Chicago, Chicago, Illinois.
authors: Jonas J
authors: JJ
authors: Staudacher
authors: Vanderbilt University, Nashville, Tennessee.
authors: Daniel
authors: D
authors: Beauchamp
mesh_terms: D028341:Activins / Q000378:metabolism; D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000378:metabolism; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000276:immunology / Q000378:metabolism*; D018095:Germ-Line Mutation; D006706:Homeostasis; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D018125:Receptors, Transforming Growth Factor beta / Q000235:genetics* / Q000276:immunology; D015398:Signal Transduction; D051785:Smad Proteins / Q000235:genetics* / Q000378:metabolism; D016212:Transforming Growth Factor beta / Q000235:genetics* / Q000378:metabolism*
chemical_list: D019485:Bone Morphogenetic Proteins; D018125:Receptors, Transforming Growth Factor beta; D051785:Smad Proteins; D016212:Transforming Growth Factor beta; D028341:Activins
keywords: Activin; Colon Cancer; Transforming Growth Factor β