title: [Cardioprotection via the arm? : How a blood pressure cuff decreases infarct sizes].
abstract: Cardiovascular diseases and especially myocardial infarctions are responsible for a high morbidity and mortality throughout Europe. An essential aspect of myocardial infarction is ischemia/reperfusion injury which represents the necrosis of myocytes following reperfusion. One possible option to counteract ischemia/reperfusion injury is the much researched process of remote ischemic conditioning (RIC), whereby a certain tissue (e.g. skeletal muscle) is subjected to several cycles of short periods (e.g. 5 min) of ischemia and reperfusion and leads to the protection of another organ (e.g. the heart). Despite substantial efforts to elucidate the underlying mechanisms during the last decades, this phenomenon is not yet completely understood. Clinical studies mainly concentrated on laboratory and radiological parameters, which led to better understanding of RIC; however, large clinical studies evaluating the possible influence on mortality are still lacking. This review article provides an introduction to RIC and summarizes the current understanding of known pathomechanisms and the results of important clinical studies.
authors: 3. Medizinische Abteilung mit Kardiologie, Wilhelminenspital Wien, Montleartstraße 37, 1160, Wien, Österreich. paul.haller@meduniwien.ac.at.|Ludwig Boltzmann Cluster für Kardiovaskuläre Forschung, Wien, Österreich. paul.haller@meduniwien.ac.at.
authors: P M
authors: PM
authors: Haller
authors: Department für Biomedizinische Forschung, Medizinische Universität Wien, Währinger Gürtel 18-20, 1090, Wien, Österreich.
authors: A
authors: A
authors: Kiss
authors: Universitätsklinik für Innere Medizin II, Medizinische Universität Wien, Wien, Österreich.|Ludwig Boltzmann Cluster für Kardiovaskuläre Forschung, Wien, Österreich.
authors: J
authors: J
authors: Wojta
authors: Department für Biomedizinische Forschung, Medizinische Universität Wien, Währinger Gürtel 18-20, 1090, Wien, Österreich. bruno.podesser@meduniwien.ac.at.|Ludwig Boltzmann Cluster für Kardiovaskuläre Forschung, Wien, Österreich. bruno.podesser@meduniwien.ac.at.
authors: B K
authors: BK
authors: Podesser
authors: 3. Medizinische Abteilung mit Kardiologie, Wilhelminenspital Wien, Montleartstraße 37, 1160, Wien, Österreich.|Ludwig Boltzmann Cluster für Kardiovaskuläre Forschung, Wien, Österreich.|Fakultät der Medizin, Sigmund Freud Privat Universität, Wien, Österreich.
authors: K
authors: K
authors: Huber
mesh_terms: D001795:Blood Pressure Determination / Q000295:instrumentation*; D003326:Coronary Circulation / Q000502:physiology; D006321:Heart / Q000503:physiopathology; D006801:Humans; D019157:Ischemic Preconditioning, Myocardial / Q000295:instrumentation*; D009203:Myocardial Infarction / Q000150:complications / Q000503:physiopathology / Q000517:prevention & control*; D015427:Reperfusion Injury / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D015899:Tomography, Emission-Computed, Single-Photon
keywords: Cardioprotection; Infarct size; Ischemia reperfusion injury; Ischemic preconditioning; Remote ischemic conditioning