title: Enabling techniques in the search for new antibiotics: Combinatorial biosynthesis of sugar-containing antibiotics.
abstract: Nature has a talent for inventing a vast number of natural products, including hybrids generated by blending different scaffolds, resulting in a myriad of bioactive chemical entities. Herein, we review the highlights and recent trends (2010-2016) in the combinatorial biosynthesis of sugar-containing antibiotics where nature's structural diversification capabilities are exploited to enable the creation of new anti-infective and anti-proliferative drugs. In this review, we describe the modern combinatorial biosynthetic approaches for polyketide synthase-derived complex and aromatic polyketides, non-ribosomal peptide synthetase-directed lipo-/glycopeptides, aminoglycosides, nucleoside antibiotics, and alkaloids, along with their therapeutic potential. Finally, we present the feasible nexus between combinatorial biosynthesis, systems biology, and synthetic biology as a toolbox to provide new antibiotics that will be indispensable in the post-antibiotic era.
authors: School of Biosystem and Biomedical Science, Korea University, Seoul 02841, Republic of Korea.
authors: Je Won
authors: JW
authors: Park
authors: Department of Chemistry and Nanoscience, Ewha Womans University, Seoul 03760, Republic of Korea.
authors: Sang-Jip
authors: SJ
authors: Nam
authors: Department of Chemistry and Nanoscience, Ewha Womans University, Seoul 03760, Republic of Korea. Electronic address: joonyoon@ewha.ac.kr.
authors: Yeo Joon
authors: YJ
authors: Yoon
mesh_terms: D000470:Alkaloids / Q000096:biosynthesis / Q000302:isolation & purification; D000818:Animals; D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000302:isolation & purification*; D001688:Biological Products / Q000302:isolation & purification*; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D006801:Humans; D009705:Nucleosides / Q000096:biosynthesis / Q000302:isolation & purification; D061065:Polyketides / Q000302:isolation & purification
chemical_list: D000470:Alkaloids; D000900:Anti-Bacterial Agents; D001688:Biological Products; D009705:Nucleosides; D061065:Polyketides
keywords: Anti-infective and anti-proliferative; Combinatorial biosynthesis; Sugar-containing antibiotics