title: Association of ghrelin with cardiometabolic risk factors in Iranian adolescents: the CASPIAN-III study.
abstract: Introduction:Current evidence suggests that ghrelin could contribute to the development of metabolic syndrome (MetS) in adults, but limited experience exists in adolescents. This study aims to explore the association of ghrelin levels with the MetS components among Iranian adolescents.Methods:In this case-control study, 32 adolescents with MetS and 148 healthy controls were selected randomly from the childhood and Adolescence Surveillance and Prevention of Adult Non communicable disease (CASPIAN-III) study. MetS was defined according to the Adult Treatment Panel III (ATP III) criteria modified for children and adolescents. Anthropometric measures (including body mass index [BMI], waist circumference [WC] and waist to height ratio [WHtR]), blood pressure (BP) and biochemical data (including fasting blood sugar [FBS], triglyceride [TG], high-density lipoprotein cholesterol [HDL-C], low-density lipoprotein cholesterol [LDL-C], total cholesterol [TC] and gerlin) were measured.Results:Total ghrelin level was significantly higher in students without MetS compared to those with MetS (748.89 ± 85.04 vs. 728.72 ± 90.36 [pg/mL];P< 0.001). Significant negative correlations were seen between ghrelin levels and BMI, WC, WHtR, TG, and TC. Ghrelin had also relatively strong inverse correlations with FBS (r = -0.59,P< 0.001), LDL-C (r = -0.56,P< 0.001), and positive correlation with HDL-C (r = 0.60,P< 0.001). Compared with the children with MetS, in those without MetS, ghrelin was significantly associated with HDL-C and LDL-C. A decreasing trend was observed in the mean ghrelin level across increasing number of MetS components (Pfor trend <0.001).Conclusion:We observed a relationship between ghrelin concentration and MetS components in adolescents.
authors: Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
authors: Ramin
authors: R
authors: Heshmat
authors: Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
authors: Gita
authors: G
authors: Shafiee
authors: Department of Community Medicine, Alborz University of Medical Sciences, Karaj, Iran ; Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
authors: Mostafa
authors: M
authors: Qorbani
authors: Department of Pediatrics, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non- Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.
authors: Fatemeh
authors: F
authors: Azizi-Soleiman
authors: Development of Research & Technology Center, Deputy of Research and Technology, Ministry of Health and Medical Education, Tehran, Iran.
authors: Shirin
authors: S
authors: Djalalinia
authors: Department of Pediatrics, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
authors: Mohammad
authors: M
authors: Esmaeil Motlagh
authors: Department of Pediatrics, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non- Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.
authors: Gelayol
authors: G
authors: Ardalan
authors: Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
authors: Zeinab
authors: Z
authors: Ahadi
authors: Department of Pediatrics, Alborz University of Medical Sciences, Karaj, Iran.
authors: Omid
authors: O
authors: Safari
authors: Managerial Epidemiology Research Center, Department of Public Health, School of Nursing and Midwifery, Maragheh University of Medical Sciences, Maragheh, Iran.
authors: Saeid
authors: S
authors: Safiri
authors: Department of Pediatrics, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non- Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.
authors: Roya
authors: R
authors: Kelishadi
keywords: Anthropometric Measures; Cardiovascular Risk Factors; Ghrelin; Metabolic Syndrome