title: [Categorization of uterine cervix tumors : What's new in the 2014 WHO classification].
abstract: In the 2014 WHO classification, squamous cell precursor lesions are classified as low-grade and high-grade intraepithelial lesions. LSIL corresponds to CIN1, HSIL includes CIN2 and CIN3. Only adenocarcinoma in situ (AIS) is accepted as precursor of adenocarcinoma and includes the stratified mucin-producing intraepithelial lesion (SMILE). Although relatively rare, adenocarcinoma and squamous cell carcinoma can be mixed with a poorly differentiated neuroendocrine carcinoma. Most cervical adenocarcinomas are low grade and of endocervical type. Mucinous carcinomas show marked intra- and extracellular mucin production. Almost all squamous cell carcinomas, the vast majority of adenocarcinomas, and many rare carcinoma types are HPV related. For low grade endocervical adenocarcinomas, the pattern-based classification according to Silva should be reported. Neuroendocrine tumors are rare and are classified into low-grade and high-grade, whereby the term carcinoid is still used.
authors: Institut für Pathologie, LKH Graz Süd-West, Standort West, Akademisches Lehrkrankenhaus der Medizinischen Universität Graz, Göstingerstrasse 22, 8020, Graz, Österreich. sigurd.lax@kages.at.
authors: S F
authors: SF
authors: Lax
authors: Institut für Pathologie, Universitätsklinikum Leipzig, Leipzig, Deutschland.
authors: L-C
authors: LC
authors: Horn
authors: Institut für Pathologie, Albertinenkrankenhaus, Hamburg, Deutschland.
authors: T
authors: T
authors: Löning
mesh_terms: D000230:Adenocarcinoma / Q000145:classification / Q000473:pathology*; D065311:Adenocarcinoma in Situ / Q000145:classification / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000145:classification / Q000473:pathology*; D002584:Cervix Uteri / Q000473:pathology; D005260:Female; D006801:Humans; D060787:Neoplasm Grading; D030361:Papillomavirus Infections / Q000145:classification / Q000473:pathology; D011379:Prognosis; D002583:Uterine Cervical Neoplasms / Q000145:classification* / Q000473:pathology*; D002578:Uterine Cervical Dysplasia / Q000145:classification / Q000473:pathology*
keywords: Adenocarcinoma; Carcinoma in situ; Human papilloma virus; Immunohistochemistry; Squamous intraepithelial lesions of the cervix