title: Endocrine manifestations in celiac disease.
abstract: Celiac disease (CD) is an autoimmune small intestinal mucosal disorder that often presents with diarrhea, malabsorption and weight loss. Often, one or more associated endocrine disorders may be associated with CD. For this review, methods involved an extensive review of published English-language materials. In children and adolescents, prospective studies have demonstrated a significant relationship to insulin-dependent or type 1 diabetes, whereas in adults, autoimmune forms of thyroid disease, particularly hypothyroidism, may commonly co-exist. In some with CD, multiple glandular endocrinopathies may also occur and complicate the initial presentation of the intestinal disease. In others presenting with an apparent isolated endocrine disorder, serological screening for underlying subclinical CD may prove to be positive, particularly if type 1 diabetes, autoimmune thyroid or other autoimmune endocrine diseases, such as Addison's disease are first detected. A number of reports have also recorded hypoparathyroidism or hypopituitarism or ovarian failure in CD and these may be improved with a strict gluten-free diet.
authors: Hugh James Freeman, Department of Medicine (Gastroenterology), University of British Columbia, Vancouver, BC V6T 1W5, Canada.
authors: Hugh James
authors: HJ
authors: Freeman
mesh_terms: D000309:Adrenal Insufficiency / Q000150:complications / Q000175:diagnosis; D001327:Autoimmune Diseases / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology; D002446:Celiac Disease / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000175:diagnosis; D004700:Endocrine System Diseases / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology; D005260:Female; D006801:Humans; D007018:Hypopituitarism / Q000150:complications / Q000175:diagnosis; D007037:Hypothyroidism / Q000150:complications / Q000175:diagnosis; D007247:Infertility, Female / Q000150:complications / Q000175:diagnosis; D015995:Prevalence; D013966:Thyroiditis / Q000150:complications / Q000175:diagnosis
keywords: Adrenal insufficiency; Celiac disease; Diabetes; Endocrine disorders; Gluten-sensitive enteropathy; Hypothyroidism; Ovarian infertility; Pituitary insufficiency; Thyroiditis