title: Base-Promoted [4 + 1]/[3 + 1 + 1] Bicyclization for Accessing Functionalized Indeno[1,2-c]furans.
abstract: A novel three-component bicyclization strategy for the metal-free synthesis of densely functionalized indeno[1,2-c]furans with generally good yields has been established from readily accessible o-phthalaldehydes (OPA), isocyanides, and α-diazoketones. The reaction pathway involves aldol-type addition, 1,2-hydride shift, 5-exo-trig cyclization, and 1,4-addition as well as an oxo-5-exo-dig cyclization sequence, resulting in continuous multiple bond-forming events including C-C and C-O bonds to rapidly build up functional oxo-heterocycles.
authors: School of Chemistry and Chemical Engineering, Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, Jiangsu Normal University , Xuzhou 221116, P. R. China.
authors: Wen-Juan
authors: WJ
authors: Hao
authors: School of Chemistry and Chemical Engineering, Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, Jiangsu Normal University , Xuzhou 221116, P. R. China.
authors: Qian
authors: Q
authors: Gao
authors: School of Chemistry and Chemical Engineering, Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, Jiangsu Normal University , Xuzhou 221116, P. R. China.
authors: Bo
authors: B
authors: Jiang
authors: School of Chemistry and Chemical Engineering, Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, Jiangsu Normal University , Xuzhou 221116, P. R. China.
authors: Feng
authors: F
authors: Liu
authors: School of Chemistry and Chemical Engineering, Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, Jiangsu Normal University , Xuzhou 221116, P. R. China.
authors: Shu-Liang
authors: SL
authors: Wang
authors: School of Chemistry and Chemical Engineering, Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, Jiangsu Normal University , Xuzhou 221116, P. R. China.
authors: Shu-Jiang
authors: SJ
authors: Tu
authors: Department of Chemistry and Biochemistry, Texas Tech University , Lubbock, Texas 79409-1061, United States.
authors: Guigen
authors: G
authors: Li