title: Water Soluble Melanin Derivatives for Dynamic Contrast Enhanced Photoacoustic Imaging of Tumor Vasculature and Response to Antiangiogenic Therapy.
abstract: A dynamic contrast enhanced (DCE) approach for tumor photoacoustic (PA) imaging is described. Novel water soluble melanin-based derivatives are synthesized that exhibit good PA properties, stability, safety and accumulation in tumor bearing mice. This melanin derivative is capable to characterize tumor vasculature and to monitor vessel permeability changes upon antiangiogenic treatment. DCE-PA imaging can assess functional response to cancer treatments.
authors: Institute of Biostructure and Bioimaging (CNR) c/o Molecular Biotechnology Center, Via Nizza 52, 10126, Torino, Italy.
authors: Dario L
authors: DL
authors: Longo
authors: Department of Molecular Biotechnology and Health Sciences, University of Torino, Via Nizza 52, 10126, Torino, Italy.
authors: Rachele
authors: R
authors: Stefania
authors: Department of Molecular Biotechnology and Health Sciences, University of Torino, Via Nizza 52, 10126, Torino, Italy.
authors: Chiara
authors: C
authors: Callari
authors: Department of Molecular Biotechnology and Health Sciences, University of Torino, Via Nizza 52, 10126, Torino, Italy.
authors: Francesco
authors: F
authors: De Rose
authors: Department of Molecular Biotechnology and Health Sciences, University of Torino, Via Nizza 52, 10126, Torino, Italy.
authors: Riccardo
authors: R
authors: Rolle
authors: Department of Molecular Biotechnology and Health Sciences, University of Torino, Via Nizza 52, 10126, Torino, Italy.
authors: Laura
authors: L
authors: Conti
authors: Department of Molecular Biotechnology and Health Sciences, University of Torino, Via Nizza 52, 10126, Torino, Italy.
authors: Lorena
authors: L
authors: Consolino
authors: Department of Molecular Biotechnology and Health Sciences, University of Torino, Via Nizza 52, 10126, Torino, Italy.
authors: Francesca
authors: F
authors: Arena
authors: Department of Molecular Biotechnology and Health Sciences, University of Torino, Via Nizza 52, 10126, Torino, Italy.
authors: Silvio
authors: S
authors: Aime
mesh_terms: D000818:Animals; D003952:Diagnostic Imaging / Q000379:methods*; D005260:Female; D008325:Mammary Neoplasms, Experimental / Q000000981:diagnostic imaging*; D008543:Melanins / Q000737:chemistry / Q000494:pharmacology*; D051379:Mice; D009389:Neovascularization, Pathologic / Q000000981:diagnostic imaging*; D061088:Photoacoustic Techniques / Q000379:methods*
chemical_list: D008543:Melanins
keywords: dynamic contrast enhanced; melanin; nanoparticles; photoacoustic; tumors