title: Role of Oxidative Stress in the Neurocognitive Dysfunction of Obstructive Sleep Apnea Syndrome.
abstract: Obstructive sleep apnea syndrome (OSAS) is characterized by chronic nocturnal intermittent hypoxia and sleep fragmentations. Neurocognitive dysfunction, a significant and extraordinary complication of OSAS, influences patients' career, family, and social life and reduces quality of life to some extent. Previous researches revealed that repetitive hypoxia and reoxygenation caused mitochondria and endoplasmic reticulum dysfunction, overactivated NADPH oxidase, xanthine oxidase, and uncoupling nitric oxide synthase, induced an imbalance between prooxidants and antioxidants, and then got rise to a series of oxidative stress (OS) responses, such as protein oxidation, lipid peroxidation, and DNA oxidation along with inflammatory reaction. OS in brain could trigger neuron injury especially in the hippocampus and cerebral cortex regions. Those two regions are fairly susceptible to hypoxia and oxidative stress production which could consequently result in cognitive dysfunction. Apart from continuous positive airway pressure (CPAP), antioxidant may be a promising therapeutic method to improve partially reversible neurocognitive function. Understanding the role that OS played in the cognitive deficits is crucial for future research and therapeutic strategy development. In this paper, recent important literature concerning the relationship between oxidative stress and cognitive impairment in OSAS will be summarized and the results can provide a rewarding overview for future breakthrough in this field.
authors: Department of Respiratory Medicine, The Second Xiangya Hospital, Central South University, 139 Renming Middle Road, Changsha, Hunan 410011, China; Research Unit of Respiratory Disease, Central South University, 139 Renming Middle Road, Changsha, Hunan 410011, China; Treatment Center of Respiratory Disease, Central South University, 139 Renming Middle Road, Changsha, Hunan 410011, China.
authors: Li
authors: 0000-0002-6271-6907
authors: L
authors: Zhou
authors: Department of Respiratory Medicine, The Second Xiangya Hospital, Central South University, 139 Renming Middle Road, Changsha, Hunan 410011, China; Research Unit of Respiratory Disease, Central South University, 139 Renming Middle Road, Changsha, Hunan 410011, China; Treatment Center of Respiratory Disease, Central South University, 139 Renming Middle Road, Changsha, Hunan 410011, China.
authors: Ping
authors: P
authors: Chen
authors: Department of Respiratory Medicine, The Second Xiangya Hospital, Central South University, 139 Renming Middle Road, Changsha, Hunan 410011, China; Research Unit of Respiratory Disease, Central South University, 139 Renming Middle Road, Changsha, Hunan 410011, China; Treatment Center of Respiratory Disease, Central South University, 139 Renming Middle Road, Changsha, Hunan 410011, China.
authors: Yating
authors: 0000-0003-2345-4059
authors: Y
authors: Peng
authors: Department of Respiratory Medicine, The Second Xiangya Hospital, Central South University, 139 Renming Middle Road, Changsha, Hunan 410011, China; Research Unit of Respiratory Disease, Central South University, 139 Renming Middle Road, Changsha, Hunan 410011, China; Treatment Center of Respiratory Disease, Central South University, 139 Renming Middle Road, Changsha, Hunan 410011, China.
authors: Ruoyun
authors: 0000-0001-5374-3455
authors: R
authors: Ouyang
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use; D001921:Brain / Q000378:metabolism; D060825:Cognitive Dysfunction / Q000209:etiology / Q000378:metabolism; D004195:Disease Models, Animal; D006801:Humans; D019255:NADPH Oxidases / Q000378:metabolism; D018384:Oxidative Stress; D020181:Sleep Apnea, Obstructive / Q000150:complications / Q000188:drug therapy / Q000473:pathology*
chemical_list: D000975:Antioxidants; D019255:NADPH Oxidases