title: Combined Stent Insertion and High-intensity Focused Ultrasound Ablation for Patients With Malignant Obstructive Jaundice.
abstract: OBJECTIVE
  We aimed to determine the clinical effectiveness of combined stent insertion and high-intensity focused ultrasound (HIFU) ablation for patients with malignant obstructive jaundice (MOJ).
  
  
  METHODS
  From June 2013 to May 2015, consecutive patients with inoperable MOJ underwent biliary stent with or without HIFU ablation in our center. Treatment-related complications, stent patency time, and survival time were compared between 2 groups.
  
  
  RESULTS
  During the enrolled time, a total of 51 patients with MOJ underwent biliary stent with HIFU ablation (n=24) or biliary stent only (n=27) in our center. There was no significant difference in baseline data between 2 groups. Relief of jaundice was achieved in all patients in both groups. Cholangitis was observed in 2 patients in stent with HIFU ablation group and 1 patient in stent only group (P=0.483). Reobstruction of stent was observed in 4 patients in stent with HIFU ablation group and 8 patients in stent only group (P=0.276). The mean stent patency time was 367±41 days in stent with HIFU ablation group and 257±35 days in stent only group (P=0.037). The mean overall survival was 238±31 days in stent with HIFU ablation group and 152±20 days in stent only group (P=0.014).
  
  
  CONCLUSIONS
  Combined biliary stent insertion and HIFU ablation is a safe and easy method for patients with MOJ, and seems to extend stent patency time and survival when compared with biliary stent only.
authors: Departments of *Interventional Radiology †Operation Room, Xuzhou Central Hospital, Xuzhou, China.
authors: Su
authors: S
authors: Niu
authors: Long
authors: L
authors: Cheng
authors: Yan
authors: Y
authors: Qiao
authors: Yu-Fei
authors: YF
authors: Fu
authors: Chi
authors: C
authors: Cao
mesh_terms: D055011:Ablation Techniques / Q000379:methods*; D001650:Bile Duct Neoplasms / Q000150:complications; D049448:Cholangiopancreatography, Magnetic Resonance; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D041781:Jaundice, Obstructive / Q000175:diagnosis / Q000209:etiology / Q000601:surgery*; D008113:Liver Neoplasms / Q000150:complications; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000150:complications; D019919:Prosthesis Implantation / Q000379:methods*; D012189:Retrospective Studies; D015607:Stents; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D059708:Ultrasonic Surgical Procedures / Q000379:methods*