title: KOtBu-Promoted Oxidation of (Hetero)benzylic Csp3-H to Ketones with Molecular Oxygen.
abstract: An efficient and practical (hetero)benzylic sp3C-H oxidation method has been developed. Notably, this user-friendly protocol employs inexpensive potassium tert-butoxide (KOtBu) as a promoter and proceeds under mild conditions using oxygen as the oxidant. A large variety of oxidation products were prepared in good to excellent yields. The utility of this "green" methodology was further demonstrated by the scale-up preparation of a biologically valued molecule.
authors: College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University , Nanyang, Henan 473061, China.
authors: Huiqiao
authors: H
authors: Wang
authors: Catalyst Plant of PetroChina, Fushun Petrochemical Company , Fushun, Liaoning 113000, China.
authors: Zhong
authors: Z
authors: Wang
authors: College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University , Nanyang, Henan 473061, China.
authors: Hongchun
authors: H
authors: Huang
authors: Department of Organic Chemistry, Faculty of Science, Beijing University of Chemical Technology , Beijing 100029, China.
authors: Jiajing
authors: J
authors: Tan
authors: College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University , Nanyang, Henan 473061, China.
authors: Kun
authors: K
authors: Xu