title: Chronic multiscale imaging of neuronal activity in the awake common marmoset.
abstract: We report a methodology to chronically record in vivo brain activity in the awake common marmoset. Over a month, stable imaging revealed macroscopic sensory maps in the somatosensory cortex and their underlying cellular activity with a high signal-to-noise ratio in the awake but not anesthetized state. This methodology is applicable to other brain regions, and will be useful for studying cortical activity and plasticity in marmosets during learning, development, and in neurological disorders.
authors: Laboratory for Developmental Neurobiology, Brain Science Institute (BSI), RIKEN, Wako, Saitama, Japan.|Central Institute for Experimental Animals, Kawasaki, Kanagawa, Japan.|Japan Science and Technology Agency, International Cooperative Research Project and Solution-Oriented Research for Science and Technology, Calcium Oscillation Project, Wako, Saitama, Japan.
authors: Yoshiyuki
authors: Y
authors: Yamada
authors: Laboratory for Developmental Neurobiology, Brain Science Institute (BSI), RIKEN, Wako, Saitama, Japan.|Central Institute for Experimental Animals, Kawasaki, Kanagawa, Japan.
authors: Yoshifumi
authors: Y
authors: Matsumoto
authors: Central Institute for Experimental Animals, Kawasaki, Kanagawa, Japan.
authors: Norio
authors: N
authors: Okahara
authors: Laboratory for Developmental Neurobiology, Brain Science Institute (BSI), RIKEN, Wako, Saitama, Japan.|Central Institute for Experimental Animals, Kawasaki, Kanagawa, Japan.|Japan Science and Technology Agency, International Cooperative Research Project and Solution-Oriented Research for Science and Technology, Calcium Oscillation Project, Wako, Saitama, Japan.
authors: Katsuhiko
authors: K
authors: Mikoshiba
mesh_terms: D000818:Animals; D001522:Behavior, Animal; D002118:Calcium / Q000032:analysis; D002135:Calcium-Binding Proteins / Q000235:genetics / Q000378:metabolism; D002144:Callithrix / Q000502:physiology*; D005260:Female; D008297:Male; D008856:Microscopy, Fluorescence / Q000295:instrumentation / Q000379:methods; D057054:Molecular Imaging; D009473:Neuronal Plasticity; D009474:Neurons / Q000502:physiology; D059629:Signal-To-Noise Ratio; D013003:Somatosensory Cortex / Q000000981:diagnostic imaging* / Q000502:physiology*; D014851:Wakefulness / Q000502:physiology*
chemical_list: D002135:Calcium-Binding Proteins; D002118:Calcium