title: In vitro and in vivo assessment of EDTA-modified silica nano-spheres with supreme capacity of iron capture as a novel antidote agent.
abstract: Mesoporous silica nanoparticles having structure of MCM-41 category with amine and EDTA functional groups in the pores were prepared using a co-condensation reaction. The synthetic steps eventuated in the mesoporous silica nanoparticles with spherical sizes lower than 50nm supposed to have high surface area. The nanoparticles' structure and functionality were characterized by FTIR spectroscopy and CHN analysis and the topography were examined by SEM and TEM and hydrodynamic sizes were demonstrated by DLS. The crystallinity and mesoporous pattern were figured out by XRD technique. Then the efficiency of these materials was tested in vitro and in vivo in adsorbing ferrous sulfate which is a supplement normally prescribed in treating iron deficiency and its overdose is potentially lethal, especially in young children. In vivo experiments illustrated that both nanoparticles could efficiently be administrated as an antidote agent against iron overdose, but EDTA-MSN nanoparticles were superior to NH2-MSN nanoparticles.
authors: Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, P.O. Box 71345-1583, Shiraz, Iran. Electronic address: farjadian_f@sums.ac.ir.
authors: Fatemeh
authors: F
authors: Farjadian
authors: Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, P.O. Box 71345-1583, Shiraz, Iran.
authors: Sahar
authors: S
authors: Ghasemi
authors: Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, P.O. Box 71345-1583, Shiraz, Iran.
authors: Reza
authors: R
authors: Heidari
authors: Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, P.O. Box 71345-1583, Shiraz, Iran; Department of Pharmaceutics, School of Pharmacy, Shiraz University of Medical Sciences, P.O. Box 71345-1583-Shiraz, Iran. Electronic address: smsamani@sums.ac.ir.
authors: Soliman
authors: S
authors: Mohammadi-Samani
mesh_terms: D000818:Animals; D000931:Antidotes; D004492:Edetic Acid; D006801:Humans; D007501:Iron / Q000506:poisoning*; D051379:Mice; D053758:Nanoparticles; D016062:Porosity; D012822:Silicon Dioxide
chemical_list: D000931:Antidotes; D012822:Silicon Dioxide; D004492:Edetic Acid; D007501:Iron
keywords: Antidote; Ferrous sulfate; In vivo; Mesoporous silica; Nanoparticle