title: Paving the way to a bioresorbable technology: Development of the absorb BRS program.
abstract: Bioresorbable scaffolds (BRS) combine attributes of the preceding generations of percutaneous coronary intervention (PCI) devices with new technologies to result in a novel therapy promoted as being the fourth generation of PCI. By providing mechanical support and drug elution to suppress restenosis, BRS initially function similarly to drug eluting stents. Thereafter, through their degradation, BRS undergo a decline in radial strength, allowing a gradual transition of mechanical function from the scaffold back to the artery in order to provide long term effectiveness similar to balloon angioplasty. The principles of operation of BRS, whether of polymeric or metallic composition, follow three phases of functionality reflective of differing physiological requirements over time: revascularization, restoration, and resorption. In this review, these three fundamental performance phases and the metrics for the nonclinical evaluation of BRS, including both bench and preclinical testing, are discussed. © 2016 Wiley Periodicals, Inc.
authors: Abbott Vascular, Preclinical Research and Biocompatibility, Santa Clara, CA.
authors: Laura E Leigh
authors: LE
authors: Perkins
authors: Abbott Vascular, Research and Development, Santa Clara, CA.
authors: Mary Beth
authors: MB
authors: Kossuth
authors: Abbott Vascular, Research and Development, Santa Clara, CA.
authors: Julia C
authors: JC
authors: Fox
authors: Abbott Vascular, Divisional Vice President of Research and Development, Santa Clara, CA. richard.rapoza@av.abbott.com.
authors: Richard J
authors: RJ
authors: Rapoza
mesh_terms: D020341:Absorbable Implants; D003324:Coronary Artery Disease / Q000601:surgery*; D054855:Drug-Eluting Stents; D006801:Humans; D062645:Percutaneous Coronary Intervention / Q000379:methods*; D011108:Polymers; D011474:Prosthesis Design; D054457:Tissue Scaffolds
chemical_list: D011108:Polymers
keywords: bioresorbable scaffolds; drug eluting stents; percutaneous coronary intervention