title: Use of AUC7 adjuvant carboplatin in patients with stage I seminoma: systematic review of the literature.
abstract: OBJECTIVE
  Among the adjuvant options to be proposed to patients with stage I seminoma after orchiectomy, the administration of a single cycle of carboplatin, at the dosage reaching an area under the curve of 7 mg/mL/min (AUC7), is a relatively recent introduction in clinical practice.
  
  
  METHODS
  On April 1, 2016, we performed a systematic review of the literature to identify studies on the use of AUC7 carboplatin in the adjuvant setting for stage I seminoma patients. The studies were identified by searching the PubMed electronic database from July 2005 up to April 2016. The aim of this review is to clarify the state of art of this adjuvant option.
  
  
  RESULTS
  Adjuvant AUC7 carboplatin is an effective adjuvant treatment, able to reduce relapse rate in stage I seminoma patients. The heterogeneity of the methods for estimation and measurement of glomerular filtration rate represents an important issue in the administration of the optimal dose of carboplatin. Even with the lack of validated prognostic factors for relapses, a risk-adapted choice is commonly used to identify the optimal patient to be proposed this treatment.
  
  
  CONCLUSIONS
  One cycle of AUC7 carboplatin is an effective, feasible, and safe adjuvant option to be discussed with stage I seminoma patients.
authors: Department of Urology, University of Verona, Ospedale Borgo Trento, Verona - Italy.
authors: Salvatore
authors: S
authors: Siracusano
authors: Department of Urology, University of Verona, Ospedale Borgo Trento, Verona - Italy.
authors: Alberto
authors: A
authors: Diminutto
authors: Department of Urology, University of Verona, Ospedale Borgo Trento, Verona - Italy.
authors: Antonio Benito
authors: AB
authors: Porcaro
authors: Department of Urology, University of Verona, Ospedale Borgo Trento, Verona - Italy.
authors: Maria Angela
authors: MA
authors: Cerruto
authors: Department of Urology, University of Verona, Ospedale Borgo Trento, Verona - Italy.
authors: Walter
authors: W
authors: Artibani
mesh_terms: D000328:Adult; D006801:Humans; D008297:Male; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics; D019540:Area Under Curve; D016190:Carboplatin / Q000008:administration & dosage; D017024:Chemotherapy, Adjuvant / Q000379:methods; D005919:Glomerular Filtration Rate / Q000187:drug effects; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy / Q000473:pathology; D009367:Neoplasm Staging / Q000379:methods; D009919:Orchiectomy / Q000379:methods; D018239:Seminoma / Q000188:drug therapy / Q000473:pathology; D013736:Testicular Neoplasms / Q000188:drug therapy; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D016190:Carboplatin
keywords: AUC7; Adjuvant; Carboplatin; Relapse; Seminoma