title: Molecular targets of developmental exposure to bisphenol A in diabesity: a focus on endoderm-derived organs.
abstract: Several studies associate foetal human exposure to bisphenol A (BPA) to metabolic/endocrine diseases, mainly diabesity. They describe the role of BPA in the disruption of pancreatic beta cell, adipocyte and hepatocyte functions. Indeed, the complexity of the diabesity phenotype is due to the involvement of different endoderm-derived organs, all targets of BPA. Here, we analyse this point delineating a picture of different mechanisms of BPA toxicity in endoderm-derived organs leading to diabesity. Moving from epidemiological data, we summarize the in vivo experimental data of the BPA effects on endoderm-derived organs (thyroid, pancreas, liver, gut, prostate and lung) after prenatal exposure. Mainly, we gather molecular data evidencing harmful effects at low-dose exposure, pointing to the risk to human health. Although the fragmentation of molecular data does not allow a clear conclusion to be drawn, the present work indicates that the developmental exposure to BPA represents a risk for endoderm-derived organs development as it deregulates the gene expression from the earliest developmental stages. A more systematic analysis of BPA impact on the transcriptomes of endoderm-derived organs is still missing. Here, we suggest in vitro toxicogenomics approaches as a tool for the identification of common mechanisms of BPA toxicity leading to the diabesity in organs having the same developmental origin.
authors: IRGS, Biogem, Ariano Irpino, Italy.
authors: I
authors: I
authors: Porreca
authors: IRGS, Biogem, Ariano Irpino, Italy.|PhD School in Nanotechnology, University of Trieste, Trieste, Italy.
authors: L
authors: L
authors: Ulloa-Severino
authors: STAB VIDA-Investigação e Serviços em Ciências Biológicas, Madan Parque, Caparica, Portugal.
authors: P
authors: P
authors: Almeida
authors: IRGS, Biogem, Ariano Irpino, Italy.
authors: D
authors: D
authors: Cuomo
authors: Department of Public Health, University of Naples 'Federico II', Naples, Italy.
authors: A
authors: A
authors: Nardone
authors: IRGS, Biogem, Ariano Irpino, Italy.|Department of Biology, University of Naples 'Federico II', Naples, Italy.
authors: G
authors: G
authors: Falco
authors: Molecular Medicine and Medical Biotechnologies, University of Naples 'Federico II', Naples, Italy.
authors: M
authors: M
authors: Mallardo
authors: IRGS, Biogem, Ariano Irpino, Italy.|Department of Science and Technology, University of Sannio, Benevento, Italy.
authors: C
authors: C
authors: Ambrosino
mesh_terms: D000818:Animals; D001559:Benzhydryl Compounds / Q000633:toxicity*; D003924:Diabetes Mellitus, Type 2 / Q000139:chemically induced / Q000503:physiopathology*; D004195:Disease Models, Animal; D004707:Endoderm / Q000187:drug effects*; D041981:Gastrointestinal Tract / Q000187:drug effects; D006801:Humans; D008099:Liver / Q000187:drug effects; D008168:Lung / Q000187:drug effects; D008297:Male; D008659:Metabolic Diseases / Q000139:chemically induced / Q000503:physiopathology*; D009765:Obesity / Q000139:chemically induced / Q000503:physiopathology*; D010179:Pancreas / Q000187:drug effects; D010636:Phenols / Q000633:toxicity*; D011467:Prostate / Q000187:drug effects; D013961:Thyroid Gland / Q000187:drug effects; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds
keywords: Bisphenol A; endoderm-derived organs; epigenetics; perinatal exposure