title: Nanomedicine as a non-invasive strategy for drug delivery across the blood brain barrier.
abstract: The blood brain barrier (BBB) is a major obstacle to drug delivery for diseases of the central nervous system (CNS). This brief review highlights the current invasive and non-invasive technologies available to address this problem. In particular, nanomedicine has shown much promise as a non-invasive strategy due to its drug loading capabilities, ease of targeting to the BBB, and small size. The versatility of this technology in terms of type of drug and imaging agent, carrier material, and targeting mechanism is highlighted in this review. The recent inclusion of imaging agents in the nanocarriers has important consequences for the field of theranostics.
authors: Chemical and Biological Engineering, Princeton University, Princeton, NJ 08544, USA. Electronic address: vtam@alumni.princeton.edu.
authors: Vivienne H
authors: VH
authors: Tam
authors: Chemical and Biological Engineering, Princeton University, Princeton, NJ 08544, USA.
authors: Chris
authors: C
authors: Sosa
authors: Chemical and Biological Engineering, Princeton University, Princeton, NJ 08544, USA.
authors: Rui
authors: R
authors: Liu
authors: Materials Science and Engineering, Princeton University, Princeton, NJ 08544, USA.
authors: Nan
authors: N
authors: Yao
authors: Chemical and Biological Engineering, Princeton University, Princeton, NJ 08544, USA.
authors: Rodney D
authors: RD
authors: Priestley
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier / Q000378:metabolism*; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods; D006801:Humans; D050997:Nanomedicine / Q000379:methods; D053758:Nanoparticles / Q000737:chemistry*; D004364:Pharmaceutical Preparations / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D004337:Drug Carriers; D004364:Pharmaceutical Preparations
keywords: Blood brain barrier; Drug delivery; Imaging; Nanomedicine; Theranostics