title: Antiviral Activity of Ergoferon against Group A Rotavirus.
abstract: Antiviral activity of Ergoferon was studied in vitro on an experimental model of rotavirus infection in MA-104 cell line. In infected cells treated with Ergoferon, rotavirus titer was shown to decrease by 83 and 90% in comparison with cells treated with solvent used for Ergoferon preparation (p<0.05) and distilled water (p<0.05), respectively. These findings demonstrate high anti-rotavirus activity of Ergoferon.
authors: Laboratory of Physiologically Active Substances, Department of Molecular and Cellular Pathology and Pathophysiology, Research Institute of General Pathology and Pathophysiology, Moscow, Russia. agemelianova@gmail.com.
authors: A G
authors: AG
authors: Emelianova
authors: State Research Center Institute of Immunology, Federal Medical-Biological Agency, Moscow, Russia.
authors: I P
authors: IP
authors: Shilovskii
authors: State Research Center Institute of Immunology, Federal Medical-Biological Agency, Moscow, Russia.
authors: M S
authors: MS
authors: Sundukova
authors: State Research Center Institute of Immunology, Federal Medical-Biological Agency, Moscow, Russia.
authors: M R
authors: MR
authors: Khaitov
authors: Laboratory of Physiologically Active Substances, Department of Molecular and Cellular Pathology and Pathophysiology, Research Institute of General Pathology and Pathophysiology, Moscow, Russia.
authors: O I
authors: OI
authors: Epshtein
mesh_terms: D000818:Animals; D000906:Antibodies / Q000494:pharmacology*; D000998:Antiviral Agents / Q000494:pharmacology*; D015704:CD4 Antigens / Q000276:immunology; D002460:Cell Line; D004622:Embryo, Mammalian; D006632:Histamine / Q000276:immunology; D054884:Host-Pathogen Interactions; D007371:Interferon-gamma / Q000037:antagonists & inhibitors; D007668:Kidney / Q000187:drug effects / Q000473:pathology / Q000821:virology; D008253:Macaca mulatta; D008826:Microbial Sensitivity Tests; D012401:Rotavirus / Q000187:drug effects* / Q000502:physiology; D019562:Viral Load / Q000187:drug effects*
chemical_list: D000906:Antibodies; D000998:Antiviral Agents; D015704:CD4 Antigens; D006632:Histamine; D007371:Interferon-gamma
keywords: Ergoferon; release-activity; rotavirus