title: [Effect of 50 mg alteplase to intermediate-risk pulmonary embolism with right ventricular dysfunction].
abstract: Objective:To investigate the effect of 50 mg alteplase to intermediate-risk acute pulmonary embolism (APE) with right ventricular dysfunction.Methods:From May 2011 to May 2015, a total of 73 patients with intermediate-risk APE, furthermore, right ventricular systolic pressure (RVSP)>40 mmHg and B-type natriuretic peptide (BNP)>100 ng/L, were allocated to receive 50 mg alteplase plus anti-coagulation (thrombolysis group, TG,n=35) or anticoagulation alone (control group CG,n=38) according to their will.Tricuspid annular plane systolic excursion (TAPSE), Right ventricular fractional area change (RVFAC), RVSP, BNP, CT obstruction index (CTOI) were detected at prior treatment, 1stday, 14thday, 3rdmonth, 6thmonth. The adverse events consisting of hemodynamic decompensation (within 14 days), mortality, bleeding, recurrent pulmonary embolism (PE), RVSP>40 mmHg (at 6thmonth) were recorded.Results:At prior treatment, TAPSE, RVFAC, RVSP, BNP and CTOI between TG and CG were (10.9±1.4) vs (11.4±1.2) mm, (27.8±3.9)% vs (28.1±4.1)%, (55.6±7.9) vs (54.6±8.4) mmHg, (491±76) vs (482±71) ng/L and (23.4±4.2)% vs (23.7±4.5)%. There was not statistical difference between two groups (allP>0.05). From 1stto 14thday, these indexes had better and faster improvement in TG than CG. At 6thmonth, TAPSE, RVFAC, RVSP and CTOI between two groups were (17.5±1.3) vs (15.4±1.1) mm, (49.4±3.9)% vs (46.0±2.8)%, (15.8±2.2) vs (17.8±4.2) mmHg, and (1.7±1.6)% vs (4.0±3.0)% (allP<0.05), BNP was (66±13) vs (71±15) ng/L (P>0.05). From prior treatment to 6thmonth, the tendency of variation of these index in TG was better than CG (P<0.05). From prior treatment to 14thday, 3 cases of hemodynamic decompensation occurred in CG, 0 case in TG.During treatment, there were not cases of death and major bleeding. At 6thmonth, there were 4 cases of RVSP>40 mmHg in CG, while 0 case in TG (P=0.048).Conclusion:50 mg alteplase can reduce the thrombus in pulmonary artery, improve right ventricular function quickly, and decrease the risk of elevated RVSP in the long term, for the patients with intermediate-risk APE.
authors: Department of Respiratory Medicine, the First Hospital of Quanzhou Affiliated Fujian Medical University, Quanzhou 362000, China.
authors: Q H
authors: QH
authors: Xu
authors: W L
authors: WL
authors: Li
authors: Z M
authors: ZM
authors: Cai
authors: Y C
authors: YC
authors: Lin
authors: S P
authors: SP
authors: Huang
mesh_terms: D006352:Heart Ventricles; D006439:Hemodynamics; D006801:Humans; D020097:Natriuretic Peptide, Brain; D011651:Pulmonary Artery; D011655:Pulmonary Embolism; D013599:Systole; D010959:Tissue Plasminogen Activator; D014261:Tricuspid Valve; D018497:Ventricular Dysfunction, Right; D016278:Ventricular Function, Right
chemical_list: D020097:Natriuretic Peptide, Brain; D010959:Tissue Plasminogen Activator