title: Assessment of growth and metabolism characteristics in offspring of dehydroepiandrosterone-induced polycystic ovary syndrome adults.
abstract: Polycystic ovary syndrome (PCOS) is a common reproductive disorder that has many characteristic features including hyperandrogenemia, insulin resistance and obesity, which may have significant implications for pregnancy outcomes and long-term health of women. Daughters born to PCOS mothers constitute a high-risk group for metabolic and reproductive derangements, but no report has described potential growth and metabolic risk factors for such female offspring. Hence, we used a mouse model of dehydroepiandrosterone (DHEA)-induced PCOS to study the mechanisms underlying the pathology of PCOS by investigating the growth, developmental characteristics, metabolic indexes and expression profiles of key genes of offspring born to the models. We found that the average litter size was significantly smaller in the DHEA group, and female offspring had sustained higher body weight, increased body fat and triglyceride content in serum and liver; they also exhibited decreased energy expenditure, oxygen consumption and impaired glucose tolerance. Genes related to glucolipid metabolism such as Pparγ, Acot1/2, Fgf21, Pdk4 and Inhbb were upregulated in the liver of the offspring in DHEA group compared with those in controls, whereas Cyp17a1 expression was significantly decreased. However, the expression of these genes was not detected in male offspring. Our results show that female offspring in DHEA group exhibit perturbed growth and glucolipid metabolism that were not observed in male offspring.
authors: Reproductive Medical CenterDepartment of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.|Key Laboratory of Assisted ReproductionMinistry of Education, Beijing, China.|Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive TechnologyBeijing, China.
authors: Ying
authors: Y
authors: Huang
authors: Reproductive Medical CenterDepartment of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.|Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive TechnologyBeijing, China.
authors: Jiang-Man
authors: JM
authors: Gao
authors: Reproductive Medical CenterDepartment of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.|Key Laboratory of Assisted ReproductionMinistry of Education, Beijing, China.
authors: Chun-Mei
authors: CM
authors: Zhang
authors: Reproductive Medical CenterDepartment of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.|Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive TechnologyBeijing, China.
authors: Hong-Cui
authors: HC
authors: Zhao
authors: Reproductive Medical CenterDepartment of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China yuyang5012@hotmail.com roseli001@sina.com zhaoyue0630@163.com.|Key Laboratory of Assisted ReproductionMinistry of Education, Beijing, China.
authors: Yue
authors: Y
authors: Zhao
authors: Reproductive Medical CenterDepartment of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China yuyang5012@hotmail.com roseli001@sina.com zhaoyue0630@163.com.|Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive TechnologyBeijing, China.
authors: Rong
authors: R
authors: Li
authors: Reproductive Medical CenterDepartment of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China yuyang5012@hotmail.com roseli001@sina.com zhaoyue0630@163.com.|Key Laboratory of Assisted ReproductionMinistry of Education, Beijing, China.|Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive TechnologyBeijing, China.
authors: Yang
authors: Y
authors: Yu
authors: Reproductive Medical CenterDepartment of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.|Key Laboratory of Assisted ReproductionMinistry of Education, Beijing, China.|Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive TechnologyBeijing, China.
authors: Jie
authors: J
authors: Qiao
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003687:Dehydroepiandrosterone / Q000633:toxicity*; D005260:Female; D005786:Gene Expression Regulation; D005951:Glucose Tolerance Test; D008099:Liver / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D008297:Male; D051379:Mice; D011085:Polycystic Ovary Syndrome / Q000139:chemically induced / Q000378:metabolism* / Q000473:pathology*; D011247:Pregnancy
chemical_list: D003687:Dehydroepiandrosterone