title: A highly versatile platform based on geometrically well-defined 3D DNA nanostructures for selective recognition and positioning of multiplex targets.
abstract: We develop a versatile recognition system based on 3D triangular-shaped DNA nanotubes by integrating three different aptamer sequences along the three edges. This would allow multiple binding activities to be combined into a single system. The versatility of this nanotube platform can also provide a framework for spatial orientation and positioning of different aptamer-binding ligands in a 'pea-pod' architecture.
authors: Department of Biology and Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon Tong, Hong Kong SAR, Chinaand Key Laboratory of Biochip Technology, Biotech and Health Centre, Shenzhen Research Institute of City University of Hong Kong, Shenzhen, 518057, China. peggylo@cityu.edu.hk.
authors: Ziwen
authors: Z
authors: Dai
authors: Department of Mechanical and Biomedical Engineering, City University of Hong Kong, Tat Chee Avenue, Kowloon Tong, Hong Kong SAR, China.
authors: Qi
authors: Q
authors: Gao
authors: Department of Biology and Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon Tong, Hong Kong SAR, Chinaand Key Laboratory of Biochip Technology, Biotech and Health Centre, Shenzhen Research Institute of City University of Hong Kong, Shenzhen, 518057, China. peggylo@cityu.edu.hk.
authors: Man Ching
authors: MC
authors: Cheung
authors: Department of Biology and Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon Tong, Hong Kong SAR, Chinaand Key Laboratory of Biochip Technology, Biotech and Health Centre, Shenzhen Research Institute of City University of Hong Kong, Shenzhen, 518057, China. peggylo@cityu.edu.hk.
authors: Hoi Man
authors: HM
authors: Leung
authors: Department of Biomedical Sciences, City University of Hong Kong, Tat Chee Avenue, Kowloon Tong, Hong Kong SAR, China.
authors: Terrence Chi Kong
authors: TC
authors: Lau
authors: Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, QC H3A 2K6, Canada.
authors: Hanadi F
authors: http://orcid.org/0000-0002-5100-0532
authors: HF
authors: Sleiman
authors: Department of Mechanical and Biomedical Engineering, City University of Hong Kong, Tat Chee Avenue, Kowloon Tong, Hong Kong SAR, China.
authors: King Wai Chiu
authors: http://orcid.org/0000-0001-5002-2273
authors: KW
authors: Lai
authors: Department of Biology and Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon Tong, Hong Kong SAR, Chinaand Key Laboratory of Biochip Technology, Biotech and Health Centre, Shenzhen Research Institute of City University of Hong Kong, Shenzhen, 518057, China. peggylo@cityu.edu.hk.
authors: Pik Kwan
authors: PK
authors: Lo
mesh_terms: D004247:DNA / Q000737:chemistry*; D043942:Nanotubes
chemical_list: D004247:DNA