title: Unclassifiable Malignant Extraovarian Sex Cord-Stromal Tumors: Report of 3 Cases and Review of Extraovarian Sex Cord-Stromal Tumors.
abstract: We report 3 cases of primary extraovarian unclassifiable malignant sex cord-stromal tumors. In all cases, the tumors involved the pelvis, peritoneum, and/or omentum and the morphologic features were essentially those of a poorly differentiated malignant neoplasm. A diagnosis of sex cord-stromal tumor was made on the basis of expression of several markers of ovarian sex cord-stromal tumors and exclusion of other neoplasms. In 1 case, an elevated serum testosterone was present at tumor progression. In reporting these cases, we draw attention to the problems in establishing a diagnosis that can be attributed to the extreme rarity of sex cord-stromal tumors in an extraovarian location and the rarity of unclassifiable malignant sex cord-stromal tumors in general, resulting in pathologists not considering this diagnosis. We review sex cord-stromal tumors occurring in an extraovarian location.
authors: Department of Pathology (R.S.), Craigavon Area Hospital, Craigavon Department of Pathology (W.G.M.), Belfast Health and Social Care Trust, Belfast, UK.
authors: Rajeev
authors: R
authors: Shah
authors: W Glenn
authors: WG
authors: McCluggage
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000145:classification* / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology; D018312:Sex Cord-Gonadal Stromal Tumors / Q000145:classification* / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor