title: Rapid ultrasound-assisted magnetic microextraction of gallic acid from urine, plasma and water samples by HKUST-1-MOF-Fe3O4-GA-MIP-NPs: UV-vis detection and optimization study.
abstract: Magnetite (Fe3O4nanoparticles (NPs)) HKUST-1 metal organic framework (MOF) composite as a support was used for surface imprinting of gallic acid imprinted polymer (HKUST-1-MOF-Fe3O4-GA-MIP) using vinyltrimethoxysilane (VTMOS) as the cross-linker. Subsequently, HKUST-1-MOF-Fe3O4-NPs-GA-MIP characterized by FT-IR, XRD and FE-SEM analysis and applied for fast and selective and sensitive ultrasound assisted dispersive magnetic solid phase microextraction of gallic acid (GA) by UV-Vis (UA-DMSPME-UV-Vis) detection method. Plackett-Burman design (PBD) and central composite design (CCD) according to desirability function (DF) indicate the significant variables among the extraction factors vortex (mixing) time (min), sonication time (min), temperature (°C), eluent volume (L), pH and HKUST-1-MOF-Fe3O4-NPs-GA-MIP mass (mg) and their contribution on the response. Optimum conditions and values correspond to pH, HKUST-1-MOF-Fe3O4-NPs-GA-MIP mass, sonication time and the eluent volume were set as follow 3.0, 1.6mg, 4.0min and 180μL, respectively. The average recovery (ER%) of GA was 98.13% with desirability of 0.997, while the present method has best operational performance like wide linear range 8-6000ngmL-1with a Limit of detection (LOD) of 1.377ngmL-1, limit of quantification (LOQ) 4.591ngmL-1and precision (<3.50% RSD). The recovery of GA in urine, human plasma and water samples within the range of 92.3-100.6% that strongly support high applicability of present method for real samples analysis, which candidate this method as promise for further application.
authors: Chemistry Department, Yasouj University, Yasouj 75918-74831, Iran.
authors: Arash
authors: A
authors: Asfaram
authors: Chemistry Department, Yasouj University, Yasouj 75918-74831, Iran. Electronic address: m_ghaedi@mail.yu.ac.ir.
authors: Mehrorang
authors: M
authors: Ghaedi
authors: Chemistry Department, Yasouj University, Yasouj 75918-74831, Iran.
authors: Kheibar
authors: K
authors: Dashtian
keywords: Fe(3)O(4) nanoparticles; Gallic acid; HKUST-1 metal organic framework; Molecularly imprinted polymer; UA-DMSPME-UV-Vis