title: Date Fruits-Assisted Synthesis and Biocompatibility Assessment of Nickel Oxide Nanoparticles Anchored onto Graphene Sheets for Biomedical Applications.
abstract: Nanographene- and graphene-based nanohybrids have garnered attention in the biomedical community owing to their biocompatibility, excellent aqueous processability, ease of cellular uptake, facile surface functionalization, and thermal and electrical conductivities. NiO nanoparticle-graphene nanohybrid (G-NiO) was synthesized by first depositing Ni(OH)2onto the surface of graphene oxide (GO) sheets. The Ni(OH)2-GO hybrids were then reduced to G-NiO using date palm syrup at 85 °C. The prepared G-NiO nanohybrids were characterized by X-ray diffraction (XRD), field-emission scanning electron microscopy (FESEM), Fourier transform infrared spectroscopy, and energy-dispersive X-ray spectroscopy (EDX). The NiO nanoparticles, with a diameter of approximately 20-30 nm, were uniformly dispersed over the surface of the graphene sheets. The G-NiO hybrids exhibit biocompatibility in human mesenchymal stem cells (hMSCs) up to 100 μg/mL. The nanohybrids do not cause any significant changes in cellular and nuclear morphologies in hMSCs. The as-synthesized nanohybrids show excellent biocompatibility and could be a promising material for biomedical applications.
authors: Nanobiotechnology and Molecular Biology Research Laboratory, Department of Food Science and Nutrition, College of Food Science and Agriculture, King Saud University, P.O. Box 2460, Riyadh, 11451, Kingdom of Saudi Arabia. alshatwi@ksu.edu.sa.
authors: Ali A
authors: AA
authors: Alshatwi
authors: Nanobiotechnology and Molecular Biology Research Laboratory, Department of Food Science and Nutrition, College of Food Science and Agriculture, King Saud University, P.O. Box 2460, Riyadh, 11451, Kingdom of Saudi Arabia.
authors: Jegan
authors: J
authors: Athinarayanan
authors: Nanobiotechnology and Molecular Biology Research Laboratory, Department of Food Science and Nutrition, College of Food Science and Agriculture, King Saud University, P.O. Box 2460, Riyadh, 11451, Kingdom of Saudi Arabia.
authors: Vaiyapuri Subbarayan
authors: VS
authors: Periasamy
authors: Nanobiotechnology and Molecular Biology Research Laboratory, Department of Food Science and Nutrition, College of Food Science and Agriculture, King Saud University, P.O. Box 2460, Riyadh, 11451, Kingdom of Saudi Arabia.
authors: Khalid A
authors: KA
authors: Alatiah
mesh_terms: D065966:Absorption, Physicochemical; D002470:Cell Survival / Q000187:drug effects; D020099:Coated Materials, Biocompatible / Q000138:chemical synthesis / Q000633:toxicity; D006108:Graphite / Q000737:chemistry* / Q000633:toxicity; D006801:Humans; D008422:Materials Testing; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000187:drug effects*; D053768:Metal Nanoparticles / Q000737:chemistry / Q000633:toxicity*; D009532:Nickel / Q000737:chemistry* / Q000633:toxicity*; D065749:Phoeniceae / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000633:toxicity
chemical_list: D020099:Coated Materials, Biocompatible; D010936:Plant Extracts; D006108:Graphite; D009532:Nickel; C028007:nickel monoxide
keywords: Biocompatibility; Graphene; Human mesenchymal stem cells; Nanohybrids; Nuclear morphology