title: Reduction of Dacarbazine cytogenetic effects on somatic cells in male mice using bee glue (Propolis) to manifest the scientific miracles in the Quran.
abstract: OBJECTIVE
  This study was carried out to investigate the ability of Propolis to ameliorate the adverse cytogenetic effects of Dacarbazine on bone marrow cells.
  
  
  METHODS
  In this experimental in vivo study, 18 mice were used, divided into four groups: control group; Propolis-treated group (treated with 50mg/kg Propolis); and Dacarbazine-treated group (treated with 3.5mg/kg Dacarbazine). The fourth, fifth, and sixth were treated with Dacarbazine and Propolis as pre 2h, post 2h, and concomitant treatment. After five days, the Bone Marrow (BM) samples were obtained for cytogenetic investigation.
  
  
  RESULTS
  Thein vivostudies revealed that Dacarbazine induced an abnormalities in polychromatic erythrocytes cells (PECs) as increase of cell with micronuclei, while the dual treatment accompanied with improvement of this abnormalities.
  
  
  CONCLUSIONS
  It could be concluded that there are protective effects of Propolis against the adverse effects of Dacarbazine. It could be recommended to use Propolis as an adjuvant with chemotherapeutic agents.
authors: Faculty of Sciences, Department of Biology "Zoology", Al Faisaliah Campus, King Abdul Aziz University, Kingdom of Saudi Arabia.
authors: Lina Abdul-Fattah
authors: LA
authors: Kurdi
authors: Faculty of Sciences, Department of Biology "Zoology", Al Faisaliah Campus, King Abdul Aziz University, Kingdom of Saudi Arabia.
authors: Fatimah Aliyan
authors: FA
authors: Aljeddani
keywords: Bone marrow cells; Cytogenetic; Dacarbazine; Mice; Propolis