title: The Inflammatory Milieu of Eosinophilic Esophagitis: A Contemporary Review With Emphasis in Putative Immunohistochemistry and Serologic Markers.
abstract: Eosinophilic esophagitis is a chronic disease characterized by esophageal dysfunction, frequent clinical history of atopy, and eosinophilic inflammation of the esophagus. Within the esophageal mucosa, there is a wide variety of immune mediators, chemotactic factors, mediators of transcription, and markers of epithelial differentiation and integrity that are overexpressed or underexpressed in eosinophilic esophagitis, offering many candidates for biomarkers with diagnostic or prognostic potential. In this review, we summarize the results from studies performed so far to evaluate the detection of these markers by immunohistochemistry on esophageal biopsies. In addition, we briefly describe some attempts to identify markers that could be detected in serum to be used to diagnose or monitor the disease without the need of a biopsy.
authors: Departments of Pathology and Laboratory Medicine.|Brown University Alpert Medical School.
authors: Marcos
authors: M
authors: Lepe
authors: Department of Biology, Brown University, Providence, RI.
authors: David
authors: D
authors: O'Connell
authors: Departments of Pathology and Laboratory Medicine.|Brown University Alpert Medical School.
authors: Kara A
authors: KA
authors: Lombardo
authors: Pediatrics, Rhode Island Hospital.
authors: Michael
authors: M
authors: Herzlinger
authors: Departments of Pathology and Laboratory Medicine.|Brown University Alpert Medical School.
authors: Shamlal
authors: S
authors: Mangray
authors: Departments of Pathology and Laboratory Medicine.|Brown University Alpert Medical School.
authors: Murray B
authors: MB
authors: Resnick
authors: Departments of Pathology and Laboratory Medicine.|Brown University Alpert Medical School.
authors: Andres
authors: A
authors: Matoso
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D001706:Biopsy; D057765:Eosinophilic Esophagitis / Q000378:metabolism / Q000473:pathology; D000071041:Esophageal Mucosa / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods
chemical_list: D015415:Biomarkers