title: Retrobulbar Injection of Amphotericin B for Orbital Mucormycosis.
abstract: A 68-year-old immunocompromised man with rhino-orbital-cerebral mucormycosis was treated with retrobulbar injections of amphotericin B deoxycholate in conjunction with intravenous antifungals and endoscopic sinus debridement. Transient episodes of orbital inflammation were noted after retrobulbar injections, but progression of orbital infection was halted and visual acuity restored with eventual hospital discharge. To the authors' knowledge, clearance of orbital mucormycosis with retrobulbar amphotericin B injections has not been previously reported. This intervention may be a viable therapeutic option in cases of orbital mucormycosis where aggressive orbital debridement is not favored and/or the burden of orbital disease is not substantial. However, physicians should be aware of the risk of transient orbital inflammation secondary to retrobulbar amphotericin B deoxycholate.
authors: Departments of *Ophthalmology and †Otolaryngology - Head and Neck Surgery, University of California, San Francisco, San Francisco, California, U.S.A.
authors: Kristin E
authors: KE
authors: Hirabayashi
authors: Evan
authors: E
authors: Kalin-Hajdu
authors: Frank L
authors: FL
authors: Brodie
authors: Robert C
authors: RC
authors: Kersten
authors: Matthew S
authors: MS
authors: Russell
authors: M Reza
authors: MR
authors: Vagefi
mesh_terms: D000368:Aged; D000666:Amphotericin B / Q000008:administration & dosage*; D000935:Antifungal Agents / Q000008:administration & dosage; D004724:Endoscopy; D015821:Eye Infections, Fungal / Q000175:diagnosis / Q000188:drug therapy*; D005500:Follow-Up Studies; D006801:Humans; D016867:Immunocompromised Host; D056965:Injections, Intraocular; D008279:Magnetic Resonance Imaging; D008297:Male; D009091:Mucormycosis / Q000175:diagnosis / Q000188:drug therapy*; D009916:Orbital Diseases / Q000175:diagnosis / Q000188:drug therapy*; D014792:Visual Acuity
chemical_list: D000935:Antifungal Agents; D000666:Amphotericin B