title: Enhanced Peroxidase-Like Properties of Graphene-Hemin-Composite Decorated with Au Nanoflowers as Electrochemical Aptamer Biosensor for the Detection of K562 Leukemia Cancer Cells.
abstract: Graphene composites with hemin and gold nanoparticles show a better performance for hydrogen peroxide decomposition compared to that of the three components alone or duplex/hybrid complexes. Our previous studies showed that the morphology of the Au nanoparticles may greatly influence the catalytic activity of graphene-family peroxidase mimics. Recently, we found that Au nanoflowers could grow in situ and form on the surface of hemin/RGO (reduced graphene oxide). The prickly morphology of this Au nanoflower brought a higher catalytic ability with enhanced kinetic parameters than traditional Au nanoparticles that showed a smooth surface. Therefore, based on this discovery, a smart electrochemical aptamer biosensor for K562 leukemia cancer cells was further presented with good performance in selectivity and sensitivity attributed to the excellent mimetic peroxidase catalytic activity of this newly synthesized Au nanoflower decorated graphene-hemin composite (H-RGO-Au NFs).
authors: Shandong Provincial Key Laboratory of Detection Technology for Tumor Markers, College of Chemistry and Chemical Engineering, Linyi University, Linyi, 276005, P.R. China.
authors: Jing
authors: J
authors: Liu
authors: Shandong Provincial Key Laboratory of Detection Technology for Tumor Markers, College of Chemistry and Chemical Engineering, Linyi University, Linyi, 276005, P.R. China.|Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Shandong Normal University, Jinan, 250014, P.R. China.
authors: Meirong
authors: M
authors: Cui
authors: Shandong Provincial Key Laboratory of Detection Technology for Tumor Markers, College of Chemistry and Chemical Engineering, Linyi University, Linyi, 276005, P.R. China.
authors: Li
authors: L
authors: Niu
authors: Shandong Provincial Key Laboratory of Detection Technology for Tumor Markers, College of Chemistry and Chemical Engineering, Linyi University, Linyi, 276005, P.R. China.
authors: Hong
authors: H
authors: Zhou
authors: Shandong Provincial Key Laboratory of Detection Technology for Tumor Markers, College of Chemistry and Chemical Engineering, Linyi University, Linyi, 276005, P.R. China.
authors: Shusheng
authors: S
authors: Zhang
mesh_terms: D015374:Biosensing Techniques / Q000379:methods*; D002384:Catalysis; D055664:Electrochemical Techniques; D006046:Gold / Q000737:chemistry*; D006108:Graphite / Q000737:chemistry*; D006801:Humans; D020014:K562 Cells; D007938:Leukemia / Q000175:diagnosis* / Q000473:pathology; D053768:Metal Nanoparticles / Q000737:chemistry*; D010084:Oxidation-Reduction; D009195:Peroxidase / Q000737:chemistry* / Q000378:metabolism
chemical_list: D006046:Gold; D006108:Graphite; D009195:Peroxidase
keywords: aptamer biosensing; cancer cells; gold; graphene; peroxidase mimics