title: Plasma-derived human factor X concentrate for on-demand and perioperative treatment in factor X-deficient patients: pharmacology, pharmacokinetics, efficacy, and safety.
abstract: Hereditary factor X (FX) deficiency is a rare autosomal recessive bleeding disorder characterized mainly by mild-to-severe bleeding into the mucous membranes, muscles or joints. Previously, treatment options for hereditary FX deficiency were limited mostly to products that may not specify FX content (i.e. fresh frozen plasma and prothrombin complex concentrates) and that have associated safety concerns. To meet the need for a single-factor replacement therapy specifically for use in FX-deficient patients, a high-purity, high-potency, human plasma-derived FX concentrate (pdFX; Coagadex®; Bio Products Laboratory, Elstree, UK) has been developed and approved for treatment of perioperative bleeding and on-demand treatment in FX-deficient patients. Areas covered: The pharmacology, efficacy, and safety of pdFX are discussed, with a review of preclinical studies and clinical trial data that led to regulatory approval of pdFX in the United States and Europe. Expert opinion: As the first single-factor replacement therapy indicated for hereditary FX deficiency, pdFX is a safe and efficacious treatment option in patients aged ≥12 years with hereditary FX deficiency. Clinical studies of pdFX provide a dosing regimen for use in cases of bleeding episodes, surgery, and prophylaxis. Further studies are ongoing regarding use of pdFX long term and in patients aged ≤12 years.
authors: a Indiana Hemophilia & Thrombosis Center , Indianapolis , IN , USA.
authors: Amy
authors: A
authors: Shapiro
mesh_terms: D000818:Animals; D016063:Blood Loss, Surgical / Q000517:prevention & control; D003029:Coagulants / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics; D004353:Drug Evaluation, Preclinical / Q000379:methods; D005170:Factor X / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics; D005171:Factor X Deficiency / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D019990:Perioperative Care / Q000379:methods
chemical_list: D003029:Coagulants; D005170:Factor X
keywords: Clotting factor concentrate; efficacy; factor X deficiency; orphan drug; pharmacokinetics; rare bleeding disorders; safety