title: [Ovarian reserve and adipokine levels in reproductive-aged obese women].
abstract: OBJECTIVE
  To investigate the relationship of the ovarian reserve to the levels of adipokines and sex hormones in reproductive-aged women with abdominal obesity.
  
  
  METHODS
  A total of 157 women aged 18 to 45 years with a body mass index (BMI) of more than 30 kg/m2 were examined (a study group). A control group consisted of 93 women aged 18-45 years with a BMI of less than 25 kg/m2. Anthropometric and carbohydrate and lipid metabolic parameters and the levels of sex hormones, anti-Müllerian hormone, resistin, and adiponectin were investigated.
  
  
  RESULTS
  The mean age of the participants with a BMI of more than 30 kg/m2 was 33.1±6.1 years and that of those with a BMI of less than 25-30 kg/m2 was 32.8±6.2 years. No statistically significant differences were found in age, ethnicity, and marital status between the participants of both groups; however, there was a statistically significant difference in education levels - 76.3% of the women with a BMI of less than 25 kg/m2 (p<0.0001) had higher education. The obese patients were found to have a statistically significant increase in the levels of insulin, HOMA-IR, glucose, total cholesterol, low-density lipoproteins, thyrotrophic hormone, testosterone, and resistin and a decrease in those of high-density lipoproteins, adiponectin, and anti-Müllerian hormone. Comparative analysis made in the obese patients revealed that there was a statistically significant correlation of anti-Müllerian hormone values and hormonal status with the levels of follicle-stimulating hormone (p=0.0026) and resistin (p=0.0323).
  
  
  CONCLUSIONS
  The ovarian reserve decreases and the processes of reproductive system aging accelerate in reproductive-aged women with abdominal obesity in the presence of insulin resistance and hyperinsulinemia.
authors: Republican Diagnostic Center, Astana, Republic of Kazakhstan.
authors: A K
authors: AK
authors: Durmanova
authors: National Medical Holding, Astana, Republic of Kazakhstan.
authors: N K
authors: NK
authors: Otarbayev
authors: Republican Diagnostic Center, Astana, Republic of Kazakhstan, National Medical Holding, Astana, Republic of Kazakhstan, Center for Life Sciences, Nazarbaev University, Astana, Republic of Kazakhstan.
authors: A
authors: A
authors: Kaiyrlykyzy
authors: Republican Diagnostic Center, Astana, Republic of Kazakhstan.
authors: K Kh
authors: KK
authors: Zhangazieva
authors: Republican Diagnostic Center, Astana, Republic of Kazakhstan.
authors: Zh N
authors: ZN
authors: Ibrayeva
authors: Republican Diagnostic Center, Astana, Republic of Kazakhstan.
authors: G B
authors: GB
authors: Donenbayeva
authors: Republican Diagnostic Center, Astana, Republic of Kazakhstan.
authors: Zh T
authors: ZT
authors: Zhusupova
authors: Republican Diagnostic Center, Astana, Republic of Kazakhstan.
authors: А S
authors: АS
authors: Saidakhmetov
authors: Republican Diagnostic Center, Astana, Republic of Kazakhstan.
authors: G Sh
authors: GS
authors: Temirgaliyeva
authors: Republican Diagnostic Center, Astana, Republic of Kazakhstan.
authors: Zh K
authors: ZK
authors: Salykbayeva
authors: Republican Diagnostic Center, Astana, Republic of Kazakhstan.
authors: Zh M
authors: ZM
authors: Tazhigulova
authors: Republican Diagnostic Center, Astana, Republic of Kazakhstan.
authors: А M
authors: АM
authors: Yensebayeva
authors: Republican Diagnostic Center, Astana, Republic of Kazakhstan.
authors: К K
authors: КK
authors: Seksembayeva
authors: Republican Diagnostic Center, Astana, Republic of Kazakhstan.
authors: О K
authors: ОK
authors: Vasilenko
authors: Republican Diagnostic Center, Astana, Republic of Kazakhstan.
authors: S
authors: S
authors: Timanova
authors: Republican Diagnostic Center, Astana, Republic of Kazakhstan.
authors: B
authors: B
authors: Akkozhina
mesh_terms: D054392:Adipokines / Q000097:blood*; D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood; D015992:Body Mass Index; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007623:Kazakhstan / Q000453:epidemiology; D009765:Obesity / Q000175:diagnosis / Q000453:epidemiology / Q000378:metabolism / Q000503:physiopathology; D065851:Ovarian Reserve; D060728:Reproductive Health / Q000706:statistics & numerical data; D052243:Resistin / Q000097:blood; D012959:Socioeconomic Factors; D013223:Statistics as Topic
chemical_list: D054392:Adipokines; D052243:Resistin; D054304:Anti-Mullerian Hormone; D005640:Follicle Stimulating Hormone