title: Prognostic Value of E-Cadherin and β-Catenin in Triple-Negative Breast Cancer.
abstract: OBJECTIVE
  To analyze the expression of E-cadherin and β-catenin in triple-negative breast cancer (TNBC) to assess their prognostic significance.
  
  
  METHODS
  The expression of E-cadherin and β-catenin was examined semiquantitatively and correlated with other pathologic factors and survival outcomes.
  
  
  RESULTS
  Of 72 consecutive TNBCs, 56% showed reduced membranous expression of E-cadherin or β-catenin, with a strong correlation to each other. Of the clinicopathologic factors analyzed, tumor size and nodal status were significantly associated with overall survival and disease-specific survival, while the latter remained an independent factor by multivariate analysis. Reduced E-cadherin and β-catenin were both significantly associated with a poor overall survival and disease-specific survival by univariate and multivariate analyses.
  
  
  CONCLUSIONS
  E-cadherin and β-catenin expression provides discriminative prognostic power independent of conventional pathologic factors, thus further reinforcing the important role of cell adhesion molecules in the process of tumor metastasis, especially in TNBC.
authors: From the Department of Pathology, the University of Alabama at Birmingham.
authors: Tiansheng
authors: T
authors: Shen
authors: Department of Mathematical Sciences, Michigan Technological University, Houghton.
authors: Kui
authors: K
authors: Zhang
authors: From the Department of Pathology, the University of Alabama at Birmingham.
authors: Gene P
authors: GP
authors: Siegal
authors: From the Department of Pathology, the University of Alabama at Birmingham.
authors: Shi
authors: S
authors: Wei
mesh_terms: D000328:Adult; D015703:Antigens, CD; D014408:Biomarkers, Tumor / Q000378:metabolism*; D015820:Cadherins / Q000378:metabolism*; D015815:Cell Adhesion Molecules / Q000378:metabolism; D005260:Female; D006801:Humans; D008875:Middle Aged; D011379:Prognosis; D064726:Triple Negative Breast Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology; D051176:beta Catenin / Q000378:metabolism*
chemical_list: D015703:Antigens, CD; D014408:Biomarkers, Tumor; C513384:CDH1 protein, human; D015820:Cadherins; D015815:Cell Adhesion Molecules; D051176:beta Catenin
keywords: Breast cancer; E-cadherin; Prognosis; Triple negative; β-catenin