title: Adding Lyso-Lipids to Arachidonate Metabolism Sets the Stage for New Biology.
abstract: Prostaglandins have been characterized as the metabolic products of arachidonic acid released from glycerophospholipids following hydrolysis by phospholipase A2s and enzymatic oxidation by the COX1 and COX2. In this issue of Cell Chemical Biology, Liu et al. (2016) examine the metabolism of 2-arachidonoyl-lyso-phosphatidylcholine and 2-arachidonoyl-lyso-phosphatidylethanolamine by COX2 and conversion to glycerolipid linked prostanoids, raising a series of interesting and important questions.
authors: Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: jshayman@umich.edu.
authors: James A
authors: JA
authors: Shayman
mesh_terms: D016718:Arachidonic Acid; D001095:Arachidonic Acids; D051546:Cyclooxygenase 2; D008246:Lysophospholipids; D015398:Signal Transduction
chemical_list: D001095:Arachidonic Acids; D008246:Lysophospholipids; D016718:Arachidonic Acid; D051546:Cyclooxygenase 2