title: Bidirectional traffic between the Golgi and the endosomes - machineries and regulation.
abstract: The bidirectional transport between the Golgi complex and the endocytic pathway has to be finely regulated in order to ensure the proper delivery of newly synthetized lysosomal enzymes and the return of sorting receptors from degradative compartments. The high complexity of these routes has led to experimental difficulties in properly dissecting and separating the different pathways. As a consequence, several models have been proposed during the past decades. However, recent advances in our understanding of endosomal dynamics have helped to unify these different views. We provide here an overview of the current insights into the transport routes between Golgi and endosomes in mammalian cells. The focus of the Commentary is on the key molecules involved in the trafficking pathways between these intracellular compartments, such as Rab proteins and sorting receptors, and their regulation. A proper understanding of the bidirectional traffic between the Golgi complex and the endolysosomal system is of uttermost importance, as several studies have demonstrated that mutations in the factors involved in these transport pathways result in various pathologies, in particular lysosome-associated diseases and diverse neurological disorders, such as Alzheimer's and Parkinson's disease.
authors: Department of Biosciences, Centre for Immune Regulation, University of Oslo, Oslo, Norway c.a.m.progida@ibv.uio.no oddmund.bakke@ibv.uio.no.
authors: Cinzia
authors: C
authors: Progida
authors: Department of Biosciences, Centre for Immune Regulation, University of Oslo, Oslo, Norway c.a.m.progida@ibv.uio.no oddmund.bakke@ibv.uio.no.
authors: Oddmund
authors: O
authors: Bakke
mesh_terms: D000818:Animals; D011992:Endosomes / Q000378:metabolism*; D006056:Golgi Apparatus / Q000378:metabolism*; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism; D021381:Protein Transport; D011956:Receptors, Cell Surface / Q000378:metabolism; D020691:rab GTP-Binding Proteins / Q000378:metabolism
chemical_list: D008565:Membrane Proteins; D011956:Receptors, Cell Surface; D020691:rab GTP-Binding Proteins
keywords: Endocytic pathway; Endolysosomal system; Golgi; Rab protein; Sorting receptor; Trans-Golgi network