title: A Novel erm(44) Gene Variant from a Human Staphylococcus saprophyticus Isolate Confers Resistance to Macrolides and Lincosamides but Not Streptogramins.
abstract: A novel erm(44) gene variant, erm(44)v, has been identified by whole-genome sequencing in a Staphylococcus saprophyticus isolate from the skin of a healthy person. It has the particularity to confer resistance to macrolides and lincosamides but not to streptogramin B when expressed in S. aureus The erm(44)vgene resides on a 19,400-bp genomic island which contains phage-associated proteins and is integrated into the chromosome of S. saprophyticus.
authors: Institute of Veterinary Bacteriology, University of Bern, Bern, Switzerland.
authors: Christian
authors: C
authors: Strauss
authors: Institute for Infection and Immunity, St George's, University of London, London, United Kingdom.
authors: Yanmin
authors: Y
authors: Hu
authors: Institute for Infection and Immunity, St George's, University of London, London, United Kingdom.
authors: Anthony
authors: A
authors: Coates
authors: Institute of Veterinary Bacteriology, University of Bern, Bern, Switzerland vincent.perreten@vetsuisse.unibe.ch.
authors: Vincent
authors: 0000-0001-5722-9445
authors: V
authors: Perreten
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics; D044404:Genomic Islands / Q000235:genetics; D006801:Humans; D055231:Lincosamides / Q000494:pharmacology*; D018942:Macrolides / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D013210:Staphylococcus / Q000187:drug effects / Q000378:metabolism; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000235:genetics; D025381:Streptogramin B / Q000494:pharmacology; D025361:Streptogramins / Q000494:pharmacology*
chemical_list: D001426:Bacterial Proteins; D055231:Lincosamides; D018942:Macrolides; D025361:Streptogramins; D025381:Streptogramin B
keywords: 23S RNA methylase; MLSB; Staphylococcus; antibiotic resistance; coagulase-negative staphylococci; macrolides-lincosamides-streptogramin B; phages