title: The Molecular and Cellular Effect of Homocysteine Metabolism Imbalance on Human Health.
abstract: Homocysteine (Hcy) is a sulfur-containing non-proteinogenic amino acid derived in methionine metabolism. The increased level of Hcy in plasma, hyperhomocysteinemia, is considered to be an independent risk factor for cardio and cerebrovascular diseases. However, it is still not clear if Hcy is a marker or a causative agent of diseases. More and more research data suggest that Hcy is an important indicator for overall health status. This review represents the current understanding of molecular mechanism of Hcy metabolism and its link to hyperhomocysteinemia-related pathologies in humans. The aberrant Hcy metabolism could lead to the redox imbalance and oxidative stress resulting in elevated protein, nucleic acid and carbohydrate oxidation and lipoperoxidation, products known to be involved in cytotoxicity. Additionally, we examine the role of Hcy in thiolation of proteins, which results in their molecular and functional modifications. We also highlight the relationship between the imbalance in Hcy metabolism and pathogenesis of diseases, such as cardiovascular diseases, neurological and psychiatric disorders, chronic kidney disease, bone tissue damages, gastrointestinal disorders, cancer, and congenital defects.
authors: Biomedical Center Martin, Department of Molecular Medicine, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, 03601 Martin, Slovakia. henrieta.skovierova@gmail.com.
authors: Henrieta
authors: H
authors: Škovierová
authors: Biomedical Center Martin, Department of Molecular Medicine, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, 03601 Martin, Slovakia. evablahovcova@gmail.com.
authors: Eva
authors: E
authors: Vidomanová
authors: Biomedical Center Martin, Department of Molecular Medicine, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, 03601 Martin, Slovakia. silvia.mahmood@jfmed.uniba.sk.
authors: Silvia
authors: S
authors: Mahmood
authors: Biomedical Center Martin, Department of Molecular Medicine, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, 03601 Martin, Slovakia. jankasopkovamt@gmail.com.|Department of Medical Biochemistry, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, 03601 Martin, Slovakia. jankasopkovamt@gmail.com.
authors: Janka
authors: J
authors: Sopková
authors: Department of Medical Biochemistry, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, 03601 Martin, Slovakia. drgova@jfmed.uniba.sk.|Biomedical Center Martin, Department of Neurosciences, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, 03601 Martin, Slovakia. drgova@jfmed.uniba.sk.
authors: Anna
authors: A
authors: Drgová
authors: Department of Public Health, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, 03601 Martin, Slovakia. mt.cervenova@uvzsl.sk.
authors: Tatiana
authors: T
authors: Červeňová
authors: Biomedical Center Martin, Department of Molecular Medicine, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, 03601 Martin, Slovakia. halasova@jfmed.uniba.sk.|Department of Medical Biology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, 03601 Martin, Slovakia. halasova@jfmed.uniba.sk.
authors: Erika
authors: E
authors: Halašová
authors: Department of Medical Biochemistry, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, 03601 Martin, Slovakia. lehotsky@jfmed.uniba.sk.|Biomedical Center Martin, Department of Neurosciences, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, 03601 Martin, Slovakia. lehotsky@jfmed.uniba.sk.
authors: Ján
authors: J
authors: Lehotský
mesh_terms: D001847:Bone Diseases / Q000473:pathology; D002318:Cardiovascular Diseases / Q000473:pathology; D002561:Cerebrovascular Disorders / Q000473:pathology; D005767:Gastrointestinal Diseases / Q000473:pathology; D006304:Health Status; D006710:Homocysteine / Q000097:blood / Q000378:metabolism*; D006801:Humans; D020138:Hyperhomocysteinemia / Q000378:metabolism*; D007674:Kidney Diseases / Q000473:pathology; D009369:Neoplasms / Q000473:pathology; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000502:physiology*; D012307:Risk Factors
chemical_list: D006710:Homocysteine
keywords: cellular toxicity; disease; homocysteine metabolism; hyperhomocysteimenia; oxidative stress