title: Bioactive and functional properties of sour cherry juice (Prunus cerasus).
abstract: Sour cherry juice (Prunus cerasus) is consumed as a nutritional supplement claiming health effects. The aim of the study was to evaluate the different properties of sour cherry juice in terms of antioxidant activity and inhibition of target enzymes in the central nervous system and diabetes. The content of polyphenols and anthocyanins was quantified. Different experiments were carried out to determine the radical scavenging properties of the juice. The activity of sour cherry juice was also tested in physiological relevant enzymes of the central nervous system (acetylcholinesterase, monoamine oxidase A, tyrosinase) and others involved in type 2 diabetes (α-glucosidase, dipeptidyl peptidase-4). Sour cherry juice showed significant antioxidant effects but the activity of the lyophilized juice was not superior to compounds such as ascorbic, gallic or chlorogenic acid. Furthermore, sour cherry juice and one of its main polyphenols known as chlorogenic acid were also able to inhibit monoamine oxidase A and tyrosinase as well as enzymes involved in diabetes. This is the first time that sour cherry juice is reported to inhibit monoamine oxidase A, α-glucosidase and dipeptidyl peptidase-4 in a dose dependent manner, which may be of interest for human health and the prevention of certain diseases.
authors: Department of Pharmacy, Faculty of Health Sciences, Universidad San Jorge, 50.830 Villanueva de Gállego, Zaragoza, Spain. ilopez@usj.es.
authors: Guillermo
authors: G
authors: Cásedas
authors: Department of Pharmacy, Faculty of Health Sciences, Universidad San Jorge, 50.830 Villanueva de Gállego, Zaragoza, Spain. ilopez@usj.es.
authors: Francisco
authors: F
authors: Les
authors: Department of Pharmacology, Faculty of Pharmacy, University Complutense of Madrid, Plaza Ramón y Cajal s/n, 28040 Madrid, Spain.
authors: Maria Pilar
authors: MP
authors: Gómez-Serranillos
authors: Department of Physiological Sciences, Science Faculty, Stellenbosch University, Stellenbosch, South Africa.
authors: Carine
authors: C
authors: Smith
authors: Department of Pharmacy, Faculty of Health Sciences, Universidad San Jorge, 50.830 Villanueva de Gállego, Zaragoza, Spain. ilopez@usj.es.
authors: Víctor
authors: http://orcid.org/0000-0001-6969-1055
authors: V
authors: López
mesh_terms: D000818:Animals; D000975:Antioxidants; D001156:Artemia / Q000187:drug effects*; D001681:Biological Assay; D002470:Cell Survival; D000067030:Fruit and Vegetable Juices / Q000032:analysis*; D055951:Functional Food; D006367:HeLa Cells; D006801:Humans; D064209:Phytochemicals / Q000737:chemistry / Q000378:metabolism; D000068220:Prunus avium / Q000737:chemistry*; D013481:Superoxides / Q000737:chemistry; D000520:alpha-Glucosidases / Q000378:metabolism
chemical_list: D000975:Antioxidants; D064209:Phytochemicals; D013481:Superoxides; D000520:alpha-Glucosidases