title: [Influence of gender on the clinical presentation and associated diseases in adults with celiac disease].
abstract: BACKGROUND
  Celiac disease is diagnosed predominantly in women.
  
  
  OBJECTIVE
  We investigated the influence of gender on (i) age at diagnosis, (ii) clinical manifestations, and (iii) prevalence of associated disorders.
  
  
  METHODS
  Clinical data were abstracted from the medical record of adults with biopsy-proven celiac disease.
  
  
  RESULTS
  The cohort consisted of 385 patients (women, 71%). Women were diagnosed at a younger age (women, 46.1 years; men, 52.6 years; p = 0.001). The prevalence of the following symptoms was higher in women: nausea/vomiting (women, 31%; men, 16%; p = 0.001), constipation (women, 21%; men, 10%; p = 0.007), and malaise/fatigue (women, 43%; men, 33%; p = 0.06). Greasy stools were more prevalent in men (women, 11%; men, 22%; p = 0.006). Autoimmune diseases were observed in 127 (33%) patients with a female to male ratio of 1.6 (women, 37%; men, 23%; p = 0.006). Depression, osteoporosis, and fibromyalgia predominated in women.
  
  
  CONCLUSIONS
  Our findings suggest clinically relevant gender-related differences in celiac disease. These gender differences should be taken into account when managing adult patients with celiac disease.
authors: Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota, EE.UU.
authors: Alberto
authors: A
authors: Rubio-Tapia
authors: Division of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, EE.UU.
authors: Claire L
authors: CL
authors: Jansson-Knodell
authors: Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota, EE.UU.
authors: Mussarat W
authors: MW
authors: Rahim
authors: Division of Endocrinology, Metabolism, and Nutrition, Mayo Clinic College of Medicine, Rochester, Minnesota, EE.UU.
authors: Jacalyn A
authors: JA
authors: See
authors: Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota, EE.UU.
authors: Joseph A
authors: JA
authors: Murray
mesh_terms: D000328:Adult; D001327:Autoimmune Diseases / Q000453:epidemiology; D002446:Celiac Disease / Q000150:complications* / Q000175:diagnosis*; D015331:Cohort Studies; D003248:Constipation / Q000453:epidemiology; D003863:Depression / Q000453:epidemiology; D005221:Fatigue / Q000453:epidemiology; D005243:Feces / Q000737:chemistry; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009325:Nausea / Q000453:epidemiology; D010024:Osteoporosis / Q000453:epidemiology; D017678:Sex Distribution; D012737:Sex Factors; D014839:Vomiting / Q000453:epidemiology