title: Role of the Intestinal Microbiota in Host Responses to Stressor Exposure.
abstract: Humans have coevolved over time to not only tolerate but also rely on trillions of microbes that aid in the development of our immune system, provide nutrients, break down potentially noxious substances, and act as a barrier against potentially pathogenic organisms. These microbes, collectively known as the microbiota, live in relatively stable communities on mucosal surfaces such as the respiratory tract and gastrointestinal tract. Changes to the microbiota are often transient, due to changes in diet, antibiotic exposure, and psychological stressor exposure. This chapter will discuss how psychological stressors can shape the intestinal microbial community and how these perturbations can contribute to stressor-induced changes in immune function, neurodevelopment, and behavioral deficits.
authors: Center for Microbial Pathogenesis, The Research Institute at Nationwide Children's Hospital, Columbus, OH, United States.
authors: A R
authors: AR
authors: Mackos
authors: Center for Microbial Pathogenesis, The Research Institute at Nationwide Children's Hospital, Columbus, OH, United States.
authors: V A
authors: VA
authors: Varaljay
authors: Center for Microbial Pathogenesis, The Research Institute at Nationwide Children's Hospital, Columbus, OH, United States; Nationwide Children's Hospital, Columbus, OH, United States.
authors: R
authors: R
authors: Maltz
authors: Wexner Medical Center at The Ohio State University, Columbus, OH, United States; The Institute for Behavioral Medicine Research (IBMR) at The Ohio State University, Columbus, OH, United States.
authors: T L
authors: TL
authors: Gur
authors: Center for Microbial Pathogenesis, The Research Institute at Nationwide Children's Hospital, Columbus, OH, United States; The Institute for Behavioral Medicine Research (IBMR) at The Ohio State University, Columbus, OH, United States; The Ohio State University College of Medicine, Columbus, OH, United States. Electronic address: michael.bailey2@nationwidechildrens.org.
authors: M T
authors: MT
authors: Bailey
mesh_terms: D001921:Brain / Q000276:immunology / Q000382:microbiology / Q000503:physiopathology; D000069196:Gastrointestinal Microbiome / Q000502:physiology*; D006801:Humans; D007422:Intestines / Q000382:microbiology*; D013315:Stress, Psychological / Q000276:immunology / Q000382:microbiology* / Q000473:pathology*
keywords: Anxiety-like behavior; Brain–gut–microbiota axis; Gut microbiota; Hypothalamic–pituitary–adrenal axis; Lactobacilli; Psychological stressors; Sympathetic nervous system