title: Patient-Derived Xenografts of Breast Cancer.
abstract: With the advancement of translational research, particularly in the field of cancer, it is now imperative to have models which more clearly reflect patient heterogeneity. Patient derived xenograft (PDX) models, which involve the orthotopic implantation of breast tumors into immune-compromised mice, recapitulate the native tumor biology. Despite the considerable challenges that establishing PDX models present, they are the ultimate model to study tumorigenesis of refractory disease and for assessing the efficacy of new pharmaceutical compounds.
authors: Endocrine Oncology Research Group, Department of Surgery, Royal College of Surgeons in Ireland, Dublin, 2, Ireland.
authors: Damir
authors: D
authors: Varešlija
authors: Endocrine Oncology Research Group, Department of Surgery, Royal College of Surgeons in Ireland, Dublin, 2, Ireland.
authors: Sinead
authors: S
authors: Cocchiglia
authors: Endocrine Oncology Research Group, Department of Surgery, Royal College of Surgeons in Ireland, Dublin, 2, Ireland.
authors: Christopher
authors: C
authors: Byrne
authors: Endocrine Oncology Research Group, Department of Surgery, Royal College of Surgeons in Ireland, Dublin, 2, Ireland. lyoung@rcsi.ie.
authors: Leonie
authors: L
authors: Young
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000473:pathology*; D063646:Carcinogenesis / Q000473:pathology; D004195:Disease Models, Animal; D005260:Female; D064593:Heterografts / Q000473:pathology; D006801:Humans; D051379:Mice; D023041:Xenograft Model Antitumor Assays / Q000379:methods
keywords: PDX; Patient-derived xenografts; Primary tissue; Translational research; Tumor fragments