title: Targeting Vascular Neural Network in Intracerebral Hemorrhage.
abstract: Intracerebral hemorrhage (ICH) is a common type of stroke associated with high mortality and morbidity. Recent randomized controlled trials could not prove that the current strategies are effective at improving the final outcome of the ICH patients.
  
  
  
  Here we want to explore potential intervention targets for ICH based on the framework of the vascular neural network (VNN). In this review, a brief history of the evolution of stroke pathophysiology from humoral theory to VNN is discussed.
  
  
  
  As current literature on pathophysiology of ICH is mainly focused on neuroprotection, here we want to evolve the central paradigm towards VNN. We stress mechanisms of vascular disruption and impaired blood flow harmony, which are clinically relevant but have received less attention in basic research.
  
  
  
  We propose that VNN could be a robust and practical paradigm in both ICH basic research and clinical practice.
authors: Department of Neurosurgery, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.
authors: Yi
authors: Y
authors: Yin
authors: Department of Neurosurgery, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.
authors: Hongfei
authors: H
authors: Ge
authors: Department of Physiology and Pharmacology, Loma Linda University, 11041 Campus Street, Risley Hall, Room 219, Loma Linda, CA 92350, United States.
authors: John H
authors: JH
authors: Zhang
authors: Department of Neurosurgery, Southwest Hospital, Third Military Medical University, 38 Gaotanyan Street, Chongqing 400038, China.
authors: Hua
authors: H
authors: Feng
mesh_terms: D002490:Central Nervous System / Q000187:drug effects* / Q000473:pathology; D002543:Cerebral Hemorrhage / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D018696:Neuroprotective Agents / Q000494:pharmacology*
chemical_list: D018696:Neuroprotective Agents
keywords: Intracerebral hemorrhage; hematoma expansion; perihematomal edema; stroke pathophysiology; vascular neural network; venous system