title: Mechanisms and Modifiers of Methylmercury-Induced Neurotoxicity.
abstract: The neurotoxic consequences of methylmercury (MeHg) exposure have long been known, however a complete understanding of the mechanisms underlying this toxicity is elusive. Recent epidemiological and experimental studies have provided many mechanistic insights, particularly into the contribution of genetic and environmental factors that interact with MeHg to modify toxicity. This review will outline cellular processes directly and indirectly affected by MeHg, including oxidative stress, cellular signaling and gene expression, and discuss genetic, environmental and nutritional factors capable of modifying MeHg toxicity.
authors: Department of Pediatrics and Department of Pharmacology, and the Kennedy Center for Research on Human Development, Vanderbilt University Medical Center, Nashville, TN, USA.
authors: Stephanie Jb
authors: SJ
authors: Fretham
authors: Department of Pediatrics and Department of Pharmacology, and the Kennedy Center for Research on Human Development, Vanderbilt University Medical Center, Nashville, TN, USA.
authors: Samuel
authors: S
authors: Caito
authors: Department of Pediatrics and Department of Pharmacology, and the Kennedy Center for Research on Human Development, Vanderbilt University Medical Center, Nashville, TN, USA.
authors: Ebany J
authors: EJ
authors: Martinez-Finley
authors: Department of Pediatrics and Department of Pharmacology, and the Kennedy Center for Research on Human Development, Vanderbilt University Medical Center, Nashville, TN, USA.
authors: Michael
authors: M
authors: Aschner