title: Effects of Melatonin on Differentiation Potential of Ito Cells in Mice with Induced Fibrosis of the Liver.
abstract: We studied the effects of melatonin on differentiation potential of Ito cells during atypical regeneration of mouse liver under conditions of CCl4-induced fibrosis. The dynamics of fibrosis was traced at the histological level and the effects of melatonin on the differentiation potential of mouse Ito cells were evaluated. Melatonin alleviated fibrotic changes in the liver tissue and reduced differentiation of Ito cells into myofibroblasts under conditions of atypical regeneration of the liver in induced fibrosis. The hepatoprotective role of melatonin was shown.
authors: M. V. Lomonosov Moscow State University, Moscow, Russia. denis.nalobin@gmail.com.
authors: D S
authors: DS
authors: Nalobin
authors: M. V. Lomonosov Moscow State University, Moscow, Russia.
authors: E A
authors: EA
authors: Suprunenko
authors: M. V. Lomonosov Moscow State University, Moscow, Russia.
authors: V A
authors: VA
authors: Golichenkov
mesh_terms: D000199:Actins / Q000235:genetics / Q000378:metabolism; D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D002251:Carbon Tetrachloride; D002454:Cell Differentiation / Q000187:drug effects; D003433:Crosses, Genetic; D005260:Female; D015870:Gene Expression; D055166:Hepatic Stellate Cells / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008103:Liver Cirrhosis / Q000139:chemically induced / Q000235:genetics / Q000473:pathology / Q000517:prevention & control*; D008115:Liver Regeneration / Q000187:drug effects; D008297:Male; D008550:Melatonin / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D058628:Myofibroblasts / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D020011:Protective Agents / Q000494:pharmacology*
chemical_list: D000199:Actins; D015415:Biomarkers; D020011:Protective Agents; C544013:alpha-smooth muscle actin, mouse; D002251:Carbon Tetrachloride; D008550:Melatonin
keywords: Ito cells; fibrosis; hepatic stellate cells; liver; melatonin