title: The frequency and severity of metabolic acidosis related to topiramate.
abstract: Objective We planned a cross-sectional analysis to determine the frequency and severity of metabolic acidosis in patients taking topiramate while awaiting craniotomy. Methods Eighty patients (18 - 65 years) taking topiramate to control seizures while awaiting elective craniotomy were enrolled. Any signs of metabolic acidosis or topiramate-related side effects were investigated. Blood chemistry levels and arterial blood gases, including lactate, were obtained. The severity of metabolic acidosis was defined according to base excess levels as mild or moderate. Results Blood gas analysis showed that 71% ( n = 57) of patients had metabolic acidosis. The frequency of moderate metabolic acidosis was 56% ( n = 45), while that of mild metabolic acidosis was 15% ( n = 12). A high respiratory rate was reported in only 10% of moderately acidotic patients. Conclusions In patients receiving topiramate, baseline blood gas analysis should be performed preoperatively to determine the presence and severity of metabolic acidosis.
authors: 1 Yeditepe University School of Medicine, Department of Anesthesiology and Reanimation.
authors: Hatice
authors: H
authors: Türe
authors: 1 Yeditepe University School of Medicine, Department of Anesthesiology and Reanimation.
authors: Özgül
authors: Ö
authors: Keskin
authors: 2 Acıbadem University School of Medicine, Department of Internal Medicine.
authors: Ülkem
authors: Ü
authors: Çakır
authors: 3 Yeditepe University School of Medicine, Department of Neurology.
authors: Canan
authors: C
authors: Aykut Bingöl
authors: 4 Yeditepe University School of Medicine, Department of Neurosurgery, Istanbul, Turkey.
authors: Uğur
authors: U
authors: Türe
mesh_terms: D000138:Acidosis / Q000097:blood / Q000175:diagnosis*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000927:Anticonvulsants / Q000008:administration & dosage / Q000009:adverse effects*; D001784:Blood Gas Analysis; D003430:Cross-Sectional Studies; D005260:Female; D005632:Fructose / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D006801:Humans; D008297:Male; D008875:Middle Aged; D056152:Respiratory Rate / Q000187:drug effects / Q000502:physiology; D012640:Seizures / Q000188:drug therapy* / Q000503:physiopathology; D012720:Severity of Illness Index; D000077236:Topiramate
chemical_list: D000927:Anticonvulsants; D000077236:Topiramate; D005632:Fructose
keywords: Metabolic acidosis; preoperative evaluation; topiramate