title: Zinc supplementation alleviates hyperglycemia and associated metabolic abnormalities in streptozotocin-induced diabetic rats.
abstract: The cause and effect relationship between diabetes and zinc is complex and unclear. This animal study has examined the potential of zinc supplementation in beneficial modulating hyperglycemia, insulin secretion, and metabolic abnormalities associated with diabetes. The study was conducted in streptozotocin-induced diabetic rats. Groups of hyperglycemic rats were subjected to dietary interventions for 6 weeks with zinc supplementation (5 times and 10 times the normal level). Supplemental-zinc-fed diabetic groups showed significant control on hyperglycemia and hypoinsulinemia. There was a significant reduction in protein glycosylation, glucosuria, and urinary excretion of proteins and urea in diabetic animals maintained on a zinc-supplemented diet. Diabetic rats showed significantly higher plasma albumin and lower plasma urea and creatinine levels upon zinc supplementation. Significant alterations in insulin sensitivity indices HOMA-IR, HOMA-B, and QUICKI were also indicated by zinc supplementation. The pathological abnormalities in pancreatic islets of diabetic animals were significantly alleviated by dietary zinc intervention. This study provides the first evidence that zinc supplementation can partially ameliorate the severity of diabetic hyperglycemia and associated metabolic abnormalities, hypoinsulinemia, insulin resistance, and altered pancreatic morphology. Thus, zinc supplementation may offer a significant potential for clinical application in managing diabetic hyperglycemia and related metabolic complications.
authors: Department of Biochemistry and Nutrition, CSIR - Central Food Technological Research Institute, Mysore 570 020, India.|Department of Biochemistry and Nutrition, CSIR - Central Food Technological Research Institute, Mysore 570 020, India.
authors: Susmita
authors: S
authors: Barman
authors: Department of Biochemistry and Nutrition, CSIR - Central Food Technological Research Institute, Mysore 570 020, India.|Department of Biochemistry and Nutrition, CSIR - Central Food Technological Research Institute, Mysore 570 020, India.
authors: Krishnapura
authors: K
authors: Srinivasan
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects / Q000502:physiology; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000378:metabolism*; D019587:Dietary Supplements; D005260:Female; D006943:Hyperglycemia / Q000188:drug therapy* / Q000378:metabolism*; D007333:Insulin Resistance / Q000502:physiology; D007515:Islets of Langerhans / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013311:Streptozocin; D015032:Zinc / Q000008:administration & dosage*
chemical_list: D001786:Blood Glucose; D013311:Streptozocin; D015032:Zinc
keywords: anomalies métaboliques; diabetes mellitus; diabète sucré; hyperglycemia; hyperglycémie; indice de sensibilité à l’insuline; insulin sensitivity index; metabolic abnormalities; supplémentation en zinc; zinc supplementation