title: Cell-based therapies for neonatal lung disease.
abstract: Preterm birth occurs in approximately 11 % of all births worldwide. Advances in perinatal care have enabled the survival of preterm infants born as early as 23-24 weeks of gestation. However, many are affected by bronchopulmonary dysplasia (BPD)-a common respiratory complication of preterm birth, which has life-long consequences for lung health. Currently, there is no specific treatment for BPD. Recent advances in stem cell research have opened new therapeutic avenues for prevention/repair of lung damage. This review summarizes recent pre-clinical data and early clinical translation of cell-based therapies for BPD.
authors: Department of Physiology and Women and Children's Health Research Institute, University of Alberta, Edmonton, AB, Canada, T6G 2E1.
authors: Megan
authors: M
authors: O'Reilly
authors: Sinclair Centre for Regenerative Medicine and Sprott Centre for Stem Cell Research, Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, ON, Canada, K1H 8L6. bthebaud@ohri.ca.|Division of Neonatology, Department of Pediatrics, Children's Hospital of Eastern Ontario (CHEO) and CHEO Research Institute, 401 Smyth Road, Ottawa, ON, Canada, K1H 5B2. bthebaud@ohri.ca.
authors: Bernard
authors: B
authors: Thébaud
mesh_terms: D001997:Bronchopulmonary Dysplasia / Q000628:therapy*; D064987:Cell- and Tissue-Based Therapy; D002986:Clinical Trials as Topic; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000628:therapy*; D008168:Lung / Q000473:pathology; D013234:Stem Cells / Q000166:cytology
keywords: Bronchopulmonary dysplasia; Lung injury; Mesenchymal stem cell; Preterm; Regeneration