title: Learning From Trials on Radiation Dose in Non-Small Cell Lung Cancer.
abstract: In this issue of the International Journal of Radiation Oncology • Biology • Physics, Taylor et al present a meta-analysis of published data supporting 2 findings: (1) radiation dose escalation seems to benefit patients who receive radiation alone for non-small cell lung cancer; and (2) radiation dose escalation has a detrimental effect on overall survival in the setting of concurrent chemotherapy. The latter finding is supported by data but has perplexed the oncology community. Perhaps these findings are not perplexing at all. Perhaps it is simply another lesson in the major principle in radiation oncology, to minimize radiation dose to normal tissues.
authors: Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri. Electronic address: jbradley@wustl.edu.
authors: Jeffrey
authors: J
authors: Bradley
authors: Division of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
authors: Chen
authors: C
authors: Hu
mesh_terms: D006801:Humans; D002289:Carcinoma, Non-Small-Cell Lung; D004307:Dose-Response Relationship, Radiation; D008175:Lung Neoplasms; D011829:Radiation Dosage