title: Magnetic Resonance Imaging-Based Radiomic Profiles Predict Patient Prognosis in Newly Diagnosed Glioblastoma Before Therapy.
abstract: Magnetic resonance imaging (MRI) is used to diagnose and monitor brain tumors. Extracting additional information from medical imaging and relating it to a clinical variable of interest is broadly defined as radiomics. Here, multiparametric MRI radiomic profiles (RPs) ofde novoglioblastoma (GBM) brain tumors is related with patient prognosis. Clinical imaging from 81 patients with GBM before surgery was analyzed. Four MRI contrasts were aligned, masked by margins defined by gadolinium contrast enhancement and T2/fluid attenuated inversion recovery hyperintensity, and contoured based on image intensity. These segmentations were combined for visualization and quantification by assigning a 4-digit numerical code to each voxel to indicate the segmented RP. Each RP volume was then compared with overall survival. A combined classifier was then generated on the basis of significant RPs and optimized volume thresholds. Five RPs were predictive of overall survival before therapy. Combining the RP classifiers into a single prognostic score predicted patient survival better than each alone (P< .005). Voxels coded with 1 RP associated with poor prognosis were pathologically confirmed to contain hypercellular tumor. This study applies radiomic profiling tode novopatients with GBM to determine imaging signatures associated with poor prognosis at tumor diagnosis. This tool may be useful for planning surgical resection or radiation treatment margins.
authors: Department of Radiology, Medical College of Wisconsin, Milwaukee, Wisconsin.
authors: Sean D
authors: SD
authors: McGarry
authors: Department of Radiology, Medical College of Wisconsin, Milwaukee, Wisconsin.
authors: Sarah L
authors: SL
authors: Hurrell
authors: Department of Radiology, Medical College of Wisconsin, Milwaukee, Wisconsin.
authors: Amy L
authors: AL
authors: Kaczmarowski
authors: Department of Pathology, Medical College of Wisconsin, Milwaukee, Wisconsin.
authors: Elizabeth J
authors: EJ
authors: Cochran
authors: Department of Neurology, Medical College of Wisconsin, Milwaukee, Wisconsin.
authors: Jennifer
authors: J
authors: Connelly
authors: Department of Radiology, Medical College of Wisconsin, Milwaukee, Wisconsin.
authors: Scott D
authors: SD
authors: Rand
authors: Department of Radiology, Medical College of Wisconsin, Milwaukee, Wisconsin; Department of Biophysics, Medical College of Wisconsin, Milwaukee, Wisconsin.
authors: Kathleen M
authors: KM
authors: Schmainda
authors: Department of Radiology, Medical College of Wisconsin, Milwaukee, Wisconsin; Department of Biophysics, Medical College of Wisconsin, Milwaukee, Wisconsin.
authors: Peter S
authors: PS
authors: LaViolette
keywords: autopsy; glioblastoma; prognosis; radiomics