title: Validity and Reliability of the Filipino Reflux Symptom Index.
abstract: OBJECTIVE
  This study aimed to establish validity and reliability of the Filipino Reflux Symptom Index (FRSI) and to test it among patients with laryngopharyngeal reflux (LPR) before and after 6 months' trial of rabeprazole.
  
  
  METHODS
  A case-control study was carried out.
  
  
  METHODS
  There were 35 LPR patients and 30 controls who were twice-administered the FRSI and Filipino Voice Handicap Index (FVHI) for test-retest reliability, and videostroboscopy was performed to obtain baseline reflux finding scores (RFSs). Patients took rabeprazole 20 mg twice daily for 6 months. The FRSI and FVHI were readministered a third time, repeat videostroboscopy was performed, and repeat RFS was obtained. Reliability, validity, and internal consistency were computed.
  
  
  RESULTS
  A total of 58 participants, 29 patients and controls each, aged 22-65 years completed the study. FVHI 2:1 and FRSI 2:1 significantly correlated with no significant differences between FRSI 2:1. FRSI had good item-total correlations indicating psychometrically sound items. There were significant differences between patients and controls for FRSI scores and mean scores. FRSI 3 scores were significantly lower than FRSI 1 scores, suggesting symptoms improved after treatment. There were no significant differences between RFS 2 and 1. Significant differences between FRSI 3 and 1, but not between FVHI 3 and 1, suggest the FRSI was more sensitive to changes in reflux after 6 months' intervention than the FVHI.
  
  
  CONCLUSIONS
  The FRSI is a valid and reliable tool for assessing LPR symptoms and may be used for primary care screening among Filipinos. Initial response to a 2-week empirical proton pump inhibitor trial may support an impression of LPR; non-response warrants specialist referral for further investigation.
authors: Professor of Otorhinolaryngology and Attending Otorhinolaryngologist, College of Medicine-Philippine General Hospital, University of the Philippines Manila, Manila, Philippines. Electronic address: lapenajf@upm.edu.ph.
authors: José Florencio F
authors: JFF
authors: Lapeña
authors: Medical Officer III (Resident Physician), Department of Otorhinolaryngology, Philippine General Hospital, University of the Philippines Manila, Manila, Philippines.
authors: Giancarla Marie C
authors: GMC
authors: Ambrocio
authors: Associate Professor of Anatomy and Clinical Associate Professor of Otorhinolaryngology, College of Medicine-Philippine General Hospital, University of the Philippines Manila, Manila, Philippines.
authors: Ryner Jose D
authors: RJD
authors: Carrillo
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D004185:Disability Evaluation; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D057045:Laryngopharyngeal Reflux / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010679:Philippines; D011237:Predictive Value of Tests; D054328:Proton Pump Inhibitors / Q000008:administration & dosage; D064750:Rabeprazole / Q000008:administration & dosage; D015203:Reproducibility of Results; D049489:Stroboscopy; D011795:Surveys and Questionnaires; D013997:Time Factors; D016896:Treatment Outcome; D014741:Video Recording; D055815:Young Adult
chemical_list: D054328:Proton Pump Inhibitors; D064750:Rabeprazole
keywords: Filipino; Laryngopharyngeal reflux; Outcome measures; Rabeprazole; Reflux symptom index