title: Peripheral adenosine levels in euthymic patients with bipolar disorder.
abstract: Recent evidence points to the involvement of the purinergic signaling in the pathophysiology of bipolar disorder. The aim of this study was to assess the serum levels of adenosine and to evaluate its relation to functioning in 24 euthymic patients with bipolar disorder type I and in 25 matched healthy controls. Subjects were evaluated using the functioning assessment short test. Serum purine levels were measured by high pressure liquid chromatography. Our results show a decrease in serum adenosine levels in bipolar disorder patients compared with controls (t= -4.8, df= 43.96, p<0.001). Moreover, a significant negative correlation was found between patient adenosine levels and depression scale scores (r= -0.642, p= 0.001). Higher functional impairment was linked to lower levels of adenosine in patients (rho= -0.551, p= 0.008). Taken together, our results provide evidence for a purinergic imbalance in bipolar disorder, specifically an adenosinergic dysfunction. Our results also indicate a relation between adenosine levels and the functional impairment caused by the disorder, which could demonstrate a potential relation of adenosine levels in worsening of symptoms.
authors: Programa de Pós-Graduação em Ciências Biológicas: Bioquímica, Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, 90035-003 Porto Alegre, RS, Brazil.
authors: Carolina
authors: C
authors: Gubert
authors: Programa de Pós-Graduação em Medicina: Ciências Médicas, Universidade Federal do Rio Grande do Sul, Hospital de Clínicas de Porto Alegre, 90035-903, Porto Alegre, RS, Brazil.
authors: Cesar Eduardo
authors: CE
authors: Jacintho Moritz
authors: Bipolar Disorder Program and Laboratory of Molecular Psychiatry, Hospital de Clínicas de Porto Alegre, 90035-003, Porto Alegre, RS, Brazil.
authors: Mirela Paiva
authors: MP
authors: Vasconcelos-Moreno
authors: Bipolar Disorder Program and Laboratory of Molecular Psychiatry, Hospital de Clínicas de Porto Alegre, 90035-003, Porto Alegre, RS, Brazil.
authors: Bárbara Tietböhl Martins
authors: BTM
authors: Quadros Dos Santos
authors: Bipolar Disorder Program and Laboratory of Molecular Psychiatry, Hospital de Clínicas de Porto Alegre, 90035-003, Porto Alegre, RS, Brazil.
authors: Juliana
authors: J
authors: Sartori
authors: Bipolar Disorder Program and Laboratory of Molecular Psychiatry, Hospital de Clínicas de Porto Alegre, 90035-003, Porto Alegre, RS, Brazil.
authors: Adam
authors: A
authors: Fijtman
authors: Programa de Pós-Graduação em Ciências Biológicas: Bioquímica, Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, 90035-003 Porto Alegre, RS, Brazil; Bipolar Disorder Program and Laboratory of Molecular Psychiatry, Hospital de Clínicas de Porto Alegre, 90035-003, Porto Alegre, RS, Brazil; INCT of Translational Medicine, Hospital de Clínicas de Porto Alegre, 90035-903 RS, Brazil; Departamento de Psiquiatria, Universidade Federal Rio Grande do Sul, 90035-903 RS, Brazil.
authors: Márcia
authors: M
authors: Kauer-Sant'Anna
authors: Bipolar Disorder Program and Laboratory of Molecular Psychiatry, Hospital de Clínicas de Porto Alegre, 90035-003, Porto Alegre, RS, Brazil; INCT of Translational Medicine, Hospital de Clínicas de Porto Alegre, 90035-903 RS, Brazil; Departamento de Psiquiatria, Universidade Federal Rio Grande do Sul, 90035-903 RS, Brazil.
authors: Flávio
authors: F
authors: Kapczinski
authors: Programa de Pós-Graduação em Ciências Biológicas: Bioquímica, Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, 90035-003 Porto Alegre, RS, Brazil; Programa de Pós-Graduação em Medicina: Ciências Médicas, Universidade Federal do Rio Grande do Sul, Hospital de Clínicas de Porto Alegre, 90035-903, Porto Alegre, RS, Brazil. Electronic address: abattastini@gmail.com.
authors: Ana Maria Oliveira
authors: AMO
authors: Battastini
authors: Bipolar Disorder Program and Laboratory of Molecular Psychiatry, Hospital de Clínicas de Porto Alegre, 90035-003, Porto Alegre, RS, Brazil; INCT of Translational Medicine, Hospital de Clínicas de Porto Alegre, 90035-903 RS, Brazil; Departamento de Psiquiatria, Universidade Federal Rio Grande do Sul, 90035-903 RS, Brazil. Electronic address: pedromaga2@gmail.com.
authors: Pedro Vieira da Silva
authors: PVDS
authors: Magalhães
mesh_terms: D000241:Adenosine / Q000097:blood*; D000328:Adult; D001714:Bipolar Disorder / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index
chemical_list: D000241:Adenosine
keywords: Adenosine; Bipolar disorder; Psychosocial functioning; Purinergic signaling; Uric acid