title: Concurrent Hemoperfusion and Hemodialysis in Patients with Acute Pesticide Intoxication.
abstract: Water soluble and insoluble chemicals in the pesticide formulation may be eliminated more effectively in time if hemodialysis (HD) and hemoperfusion (HP) are performed concurrently.
  
  
  
  This study is aimed at evaluating the efficacy of concurrent HP and HD in patients with acute pesticide intoxication.
  
  
  
  Between January 2011 and December 2012, we used HP and HD consecutively (HP-HD group, 347 cases), and then during the next 2 years (January 2013 to December 2014), we used concurrent HP and HD (HPD group, 383 cases). We compared the clinical outcomes between the 2 groups.
  
  
  
  The mortality was higher in the HP-HD group than in the HPD group: (48.1 vs. 20.9%) for the overall mortality and (81.8 vs. 57.9%) for the paraquat (bipyridylium) mortality (p < 0.001). In multiple logistic analyses, age (p = 0.013), ingested volume (p < 0.001), and HP-HD (p = 0.014) were significant risk factors for mortality in the paraquat ingested group.
  
  
  
  Concurrent HP and HD would be an effective and safe treatment for patients with acute pesticide intoxication, in particular, paraquat intoxication.
authors: Department of Internal Medicine, Cheonan, Seoul, Korea.
authors: Samel
authors: S
authors: Park
authors: Sunhyo
authors: S
authors: Lee
authors: Suyeon
authors: S
authors: Park
authors: Hyowook
authors: H
authors: Gil
authors: Eunyoung
authors: E
authors: Lee
authors: Jongoh
authors: J
authors: Yang
authors: Saeyong
authors: S
authors: Hong
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers; D064419:Chemically-Induced Disorders / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D006464:Hemoperfusion / Q000009:adverse effects / Q000379:methods; D006540:Herbicides / Q000633:toxicity; D006801:Humans; D008297:Male; D008875:Middle Aged; D010269:Paraquat / Q000633:toxicity; D010575:Pesticides / Q000633:toxicity*; D011446:Prospective Studies; D006435:Renal Dialysis / Q000009:adverse effects / Q000379:methods; D012307:Risk Factors; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D006540:Herbicides; D010575:Pesticides; D010269:Paraquat