title: Medicinal plants used in Lesotho for treatment of reproductive and post reproductive problems.
abstract: BACKGROUND
  Reproductive healthcare has been highlighted as a major challenge in Lesotho mainly due to the high prevalence of HIV/AIDS and sexually transmitted infections. As a result other reproductive ailments have not received much attention, particularly because healthcare facilities are already limited and many of them are inaccessible. For these reasons, medicinal plants play a major role in primary healthcare system in the country, in addition the plants are easily accessible, more affordable, and their use forms part of the cultural heritage. However, documentation of medicinal plants used for reproductive ailments is scattered, more importantly the biological and pharmacological properties, as well as toxicity of many of these plants are not yet known.
  
  
  OBJECTIVE
  To document the plants used by both male and female Basotho (residing in Lesotho) for the treatment of reproductive ailments, to explore their recorded biological and pharmacological effects as well as their toxicity, and to establish if these plants are used for similar purposes in other southern African cultures.
  
  
  METHODS
  The results stem from published findings of recent interviews of traditional medicinal practitioners in the Maseru District of Lesotho, first author's own experiences and observations from the Qacha's Nek District as well as comprehensive literature survey including numerous books and unpublished data. Electronic databases such as Google, Google Scholar, PubMed, and ScienceDirect were also used to search for the chemical compounds, pharmacological activity, and toxicity of the plants.
  
  
  RESULTS
  A total of 87 plant species are reported to be used for the treatment of several reproductive problems such as infertility, complications associated with pregnancy (twelve plants are used to treat conditions such as colic, heartburn, nausea, and constipation), cleansing and/ or toning of the uterus (with a purpose either to induce pregnancy or to get rid of the placenta, for example Withania somnifera and Zantedeschia albomaculata), difficult childbirth, as well treatment of breast and cervical cancer, cysts, fibroids, and testicular tumours (e.g. Hypoxis hemerocallidea). For the toning of the uterus, it is common to use a combination of plants, e.g. Gunnera perpensa, Scabiosa columbaria, and Eriospermum ornithogaloides.
  
  
  CONCLUSIONS
  Of the 87 plants used for reproductive healthcare, the highest number (31) is used for the treatment of infertility (in both men and women). The pharmacological effects, active compounds, and toxicology of many of these plants are not yet known.
authors: Department of Botany and Plant Biotechnology, University of Johannesburg, P.O. Box 524, Auckland Park 2006, Johannesburg, South Africa. Electronic address: amoteetee@uj.ac.za.
authors: A
authors: A
authors: Moteetee
authors: Department of Botany and Plant Biotechnology, University of Johannesburg, P.O. Box 524, Auckland Park 2006, Johannesburg, South Africa.
authors: L
authors: L
authors: Seleteng Kose
mesh_terms: D005260:Female; D006801:Humans; D007246:Infertility / Q000188:drug therapy; D007927:Lesotho; D008297:Male; D008519:Medicine, Traditional / Q000379:methods; D008517:Phytotherapy / Q000379:methods; D028321:Plant Preparations / Q000627:therapeutic use*; D010946:Plants, Medicinal / Q000737:chemistry*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy; D012098:Reproduction / Q000187:drug effects*
chemical_list: D028321:Plant Preparations
keywords: Aloin (PubChem CID: 12305761); Anthraquinone (PubChem CID: 6770); Berberine (PubChem CID: 2353); Childbirth; Coumestrol (PubChem CID: 5281707); Dysmenorrhoea; Genistein (PubChem CID: 5280961); Infertility; Loganin (PubChem CID: 87691); Menorrhagia; Protopine (PubChem CID: 4970); Reproductive problems; Sanguinarine (PubChem CID: 5154); Sesquisabinene (PubChem CID: 25202482); Swerodside (PubChem CID: 161036); Thujone (PubChem CID: 91456); Uzarin (PubChem CID: 20055063); Withanolide (PubChem CID: 161671); Xysmalorin (PubChem CID: 208007), www.ncbi.nlm.nih.gov/pccompound (accessed 07-06-2016)