title: Pathogenic factors in Candida biofilm-related infectious diseases.
abstract: Candida albicans is a commonly found member of the human microflora and is a major human opportunistic fungal pathogen. A perturbation of the microbiome can lead to infectious diseases caused by various micro-organisms, including C. albicans. Moreover, the interactions between C. albicans and bacteria are considered to play critical roles in human health. The major biological feature of C. albicans, which impacts human health, resides in its ability to form biofilms. In particular, the extracellular matrix (ECM) of Candida biofilm plays a multifaceted role and therefore may be considered as a highly attractive target to combat biofilm-related infectious diseases. In addition, extracellular DNA (eDNA) also plays a crucial role in Candida biofilm formation and its structural integrity and induces the morphological transition from yeast to the hyphal growth form during C. albicans biofilm development. This review focuses on pathogenic factors such as eDNA in Candida biofilm formation and its ECM production and provides meaningful information for future studies to develop a novel strategy to battle infectious diseases elicited by Candida-formed biofilm.
authors: Department of Oral Microbiology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.
authors: K
authors: K
authors: Hirota
authors: Department of Conservative Dentistry, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.
authors: H
authors: H
authors: Yumoto
authors: Department of Oral and Maxillofacial Prosthodontics, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.
authors: B
authors: B
authors: Sapaar
authors: Department of Conservative Dentistry, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.
authors: T
authors: T
authors: Matsuo
authors: Department of Oral and Maxillofacial Prosthodontics, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.
authors: T
authors: T
authors: Ichikawa
authors: Department of Oral Microbiology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.
authors: Y
authors: Y
authors: Miyake
mesh_terms: D018441:Biofilms; D002175:Candida / Q000145:classification / Q000502:physiology; D002176:Candida albicans / Q000472:pathogenicity / Q000502:physiology*; D002177:Candidiasis / Q000382:microbiology; D004247:DNA / Q000378:metabolism; D006801:Humans; D025301:Hyphae / Q000502:physiology; D053038:Quorum Sensing; D012141:Respiratory Tract Infections / Q000382:microbiology; D037521:Virulence Factors / Q000378:metabolism
chemical_list: D037521:Virulence Factors; D004247:DNA
keywords: 
  Candida
  ; anaerobic; biofilm development; extracellular DNA; extracellular matrix; hyphal form