title: Early detection of pancreatic cancer: impact of high-resolution imaging methods and biomarkers.
abstract: High-resolution imaging methods (HRIMs) and biomarkers present the second step of pancreatic cancer (PC) diagnostics in at-risk individuals. These include patients with positive risk factors, early symptoms, nonresponders to the initial antidiabetic therapy, patients older than 50 years of age with new-onset unstable diabetes requiring insulin as well as patients with long-term insulin-non-dependent diabetes and recent (up to 6 months) failure of antidiabetic therapy. The procedures should be started without delay and the co-operation between the primary and tertiary medical centers is highly desirable. An early indication of HRIMs and biomarkers is a prerequisite for the diagnosis of a resectable PC. This publication reviews the recent contribution of HRIMs and biomarkers toward an early diagnosis of PC.
authors: Departments of aMedicine/GastroenterologybPathologycSurgery, Military University HospitaldLaboratory of Endocrinology and MetabolismeInstitute of Biochemistry and Experimental OncologyfInstitute of Clinical Biochemistry and Laboratory Diagnostics, General University Hospital, 1st and 2nd Faculty of MedicinegDepartment of Medicine, 3rd Faculty of Medicine, Charles University, Prague, Czech Republic.
authors: Přemysl
authors: P
authors: Frič
authors: Jan
authors: J
authors: Škrha
authors: Aleksi
authors: A
authors: Šedo
authors: Tomaš
authors: T
authors: Zima
authors: Petr
authors: P
authors: Bušek
authors: Klára
authors: K
authors: Kmochová
authors: Martin
authors: M
authors: Laclav
authors: Bohuš
authors: B
authors: Bunganič
authors: Svatopluk
authors: S
authors: Solař
authors: Petr
authors: P
authors: Hrabal
authors: František
authors: F
authors: Bělina
authors: Pavel
authors: P
authors: Záruba
authors: Pavel
authors: P
authors: Škrha
authors: Miroslav
authors: M
authors: Zavoral
mesh_terms: D000236:Adenoma / Q000000981:diagnostic imaging* / Q000235:genetics / Q000378:metabolism; D000906:Antibodies / Q000378:metabolism; D015415:Biomarkers; D002278:Carcinoma in Situ / Q000000981:diagnostic imaging* / Q000235:genetics / Q000378:metabolism; D021441:Carcinoma, Pancreatic Ductal / Q000000981:diagnostic imaging* / Q000235:genetics / Q000378:metabolism; D002760:Cholangiopancreatography, Endoscopic Retrograde; D049448:Cholangiopancreatography, Magnetic Resonance; D055088:Early Detection of Cancer / Q000379:methods*; D054459:Elasticity Imaging Techniques; D019160:Endosonography; D006801:Humans; D008279:Magnetic Resonance Imaging; D035683:MicroRNAs / Q000235:genetics*; D061330:Multidetector Computed Tomography; D018297:Neoplasms, Cystic, Mucinous, and Serous / Q000000981:diagnostic imaging* / Q000235:genetics / Q000378:metabolism; D010190:Pancreatic Neoplasms / Q000000981:diagnostic imaging* / Q000235:genetics / Q000378:metabolism; D051190:Plectin / Q000378:metabolism; D000072078:Positron Emission Tomography Computed Tomography; D014463:Ultrasonography
chemical_list: D000906:Antibodies; D015415:Biomarkers; C467479:DAS-1 protein, human; D035683:MicroRNAs; C495332:PLEC protein, human; D051190:Plectin