title: Association Between Life's Simple 7 and Noncardiovascular Disease: The Multi-Ethnic Study of Atherosclerosis.
abstract: The American Heart Association introduced the Life's Simple 7 (LS7) metrics to assess and promote cardiovascular health. We examined the association between the LS7 metrics and noncardiovascular disease.
  
  
  
  We studied 6506 men and women aged between 45 and 84 years, enrolled in the Multi-Ethnic Study of Atherosclerosis. Median follow-up time was 10.2 years. Each component of the LS7 metrics (smoking, body mass index, physical activity, diet, total cholesterol, blood pressure, and blood glucose) was assigned points, 0 indicates "poor" category; 1, "intermediate," and 2, "ideal." The LS7 score, ranged from 0 to 14, was created from the points and categorized as optimal (11-14), average (9-10), and inadequate (0-8). Hazard ratios and event rates per 1000 person-years were calculated for outcomes based on self-reported hospitalizations with the International Classification of Diseases, 9th Revision, diagnoses of cancer, chronic kidney disease, pneumonia, deep venous thromboembolism/pulmonary embolism, chronic obstructive pulmonary disease, dementia, and hip fracture. Analyses were adjusted for age, sex, race/ethnicity, income, and education. Overall, noncardiovascular disease event rates were lower with increasing LS7 scores. With the inadequate LS7 score as reference, an optimal score was associated with a decreased risk for noncardiovascular disease events. The hazard ratio for cancer was, 0.80 (0.64-0.98); chronic kidney disease, 0.38 (0.27-0.54); pneumonia, 0.57 (0.40-0.80); deep venous thromboembolism/pulmonary embolism, 0.52 (0.33-0.82), and chronic obstructive pulmonary disease, 0.51 (0.31-0.83).
  
  
  
  The American Heart Association's LS7 score identified individuals who were vulnerable to multiple chronic nonvascular conditions. These results suggest that improving cardiovascular health will also reduce the burden of cancer and other chronic diseases.
authors: Center for Healthcare Advancement and Outcomes, Baptist Health South Florida, Miami, FL Department of Epidemiology, Robert Stempel College of Public Health and Social Work, Florida International University, Miami, FL.
authors: Oluseye
authors: O
authors: Ogunmoroti
authors: Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL.
authors: Norrina B
authors: NB
authors: Allen
authors: Department of Medicine, Cardiovascular Research Institute, University of Vermont, Burlington, VT.
authors: Mary
authors: M
authors: Cushman
authors: Ciccarone Center for the Prevention of Heart Disease, Johns Hopkins University, Baltimore, MD.
authors: Erin D
authors: ED
authors: Michos
authors: Department of Neurology, Miller School of Medicine, University of Miami, FL.
authors: Tatjana
authors: T
authors: Rundek
authors: Division of Cardiology and Division of Research, Kaiser Permanente Northern California, Oakland, CA Department of Medicine, University of California, San Francisco, CA.
authors: Jamal S
authors: JS
authors: Rana
authors: Departments of Medicine and Radiology, Brigham and Women's Hospital, Boston, MA.
authors: Ron
authors: R
authors: Blankstein
authors: Ciccarone Center for the Prevention of Heart Disease, Johns Hopkins University, Baltimore, MD.
authors: Roger S
authors: RS
authors: Blumenthal
authors: Ciccarone Center for the Prevention of Heart Disease, Johns Hopkins University, Baltimore, MD.
authors: Michael J
authors: MJ
authors: Blaha
authors: Center for Healthcare Advancement and Outcomes, Baptist Health South Florida, Miami, FL Department of Biostatistics, Robert Stempel College of Public Health and Social Work, Florida International University, Miami, FL.
authors: Emir
authors: E
authors: Veledar
authors: Center for Healthcare Advancement and Outcomes, Baptist Health South Florida, Miami, FL Miami Cardiac & Vascular Institute, Baptist Health South Florida, Miami, FL Department of Epidemiology, Robert Stempel College of Public Health and Social Work, Florida International University, Miami, FL Department of Medicine, Herbert Wertheim College of Medicine, Florida International University, Miami, FL Ciccarone Center for the Prevention of Heart Disease, Johns Hopkins University, Baltimore, MD khurramn@baptisthealth.net.
authors: Khurram
authors: K
authors: Nasir
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000572:American Heart Association; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D015992:Body Mass Index; D002784:Cholesterol / Q000097:blood; D015331:Cohort Studies; D003704:Dementia / Q000453:epidemiology*; D004032:Diet; D015444:Exercise; D005260:Female; D005500:Follow-Up Studies; D006620:Hip Fractures / Q000453:epidemiology*; D006801:Humans; D008019:Life Style; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000453:epidemiology*; D009765:Obesity / Q000453:epidemiology; D050177:Overweight / Q000453:epidemiology; D011014:Pneumonia / Q000453:epidemiology*; D016016:Proportional Hazards Models; D011446:Prospective Studies; D029424:Pulmonary Disease, Chronic Obstructive / Q000453:epidemiology*; D011655:Pulmonary Embolism / Q000453:epidemiology*; D051436:Renal Insufficiency, Chronic / Q000453:epidemiology*; D012307:Risk Factors; D012907:Smoking / Q000453:epidemiology; D014481:United States / Q000453:epidemiology; D020246:Venous Thrombosis / Q000453:epidemiology*
chemical_list: D001786:Blood Glucose; D002784:Cholesterol
keywords: Life's Simple 7; epidemiology; prevention; risk factor