title: In vivo sedative activity of methanolic extract of Stericulia villosa Roxb. leaves.
abstract: BACKGROUND
  This plant is very popular ingredient of local made drinks during hot summer. After drinking this drink people feels fresh, relaxed and can enjoy sound sleep. Present study was aimed to assess the sedative properties of a plant Sterculia villosa leaves. Therefore, we tried to find out the methanolic extract from the leaves of Sterculia villosa leaves having any sedative activity or not.
  
  
  METHODS
  The extract were subjected to various in vivo methods like hole cross test, open field test, elevated plus-maze (EPM) test, thiopental sodium induced sleeping time test. Diazepam was used as the standard drug.
  
  
  RESULTS
  From the study, it is clear that the extract has excellent CNS depressant activity by reducing locomotors activity of mice in every cases of hole cross test, open field test, elevated plus-maze (EPM) test compared to the standard diazepam. In addition, the extract prolong the sleeping time (230 min) with quick onset of action (9 min) in contrast to the standard and control group.
  
  
  CONCLUSIONS
  From the present study it can be conclude that the extract posses significant a sedative property that may lead to new drug development and further investigation is necessary to understand the underlying mechanisms and to isolate the active principles.
authors: Department of Pharmacy, Institute of Health Technology, Fouzderhat, Chittagong, Bangladesh.
authors: Md Forhad
authors: MF
authors: Hossain
authors: Department of Pharmacy, Institute of Health Technology, Fouzderhat, Chittagong, Bangladesh.
authors: Bashudeb
authors: B
authors: Talukder
authors: School of Allied Health Sciences and Public Health, Walailak University, Thai Buri, Thailand.
authors: Mohammad Nasiruddin
authors: MN
authors: Rana
authors: State University of Bangladesh, Dhaka, Bangladesh.
authors: Refat
authors: R
authors: Tasnim
authors: Department of Pharmacy, University of Chittagong, Chittagong, Bangladesh.
authors: Tanzina Sharmin
authors: TS
authors: Nipun
authors: Department of Pharmacy, University of Chittagong, Chittagong, Bangladesh.
authors: S M Naim
authors: SM
authors: Uddin
authors: Department of Pharmacy, University of Chittagong, Chittagong, Bangladesh. hossen.pharmacy@cu.ac.bd.
authors: S M Moazzem
authors: SM
authors: Hossen
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D006993:Hypnotics and Sedatives / Q000737:chemistry / Q000494:pharmacology*; D008124:Locomotion / Q000187:drug effects; D018782:Maze Learning / Q000187:drug effects; D000432:Methanol; D051379:Mice; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry*; D032361:Sterculia / Q000737:chemistry*
chemical_list: D006993:Hypnotics and Sedatives; D010936:Plant Extracts; D000432:Methanol
keywords: CNS depressant activity; Herbal preparations; Locomotor activity; Sedative properties