title: DNA interaction, antimicrobial studies of newly synthesized copper (II) complexes with 2-amino-6-(trifluoromethoxy)benzothiazole Schiff base ligands.
abstract: Four novel Schiff base ligands, L1(1-((E)-(6-(trifluoromethoxy)benzo[d]thiazol-2-ylimino)methyl)naphthalen-2-ol, C19H11F3N2O2S), L2(3-((E)-(6-(trifluoromethoxy)benzo[d]thiazol-2-ylimino)methyl)benzene-1,2-diol, C15H9F3N2O3S), L3(2-((E)-(6-(trifluoromethoxy)benzo[d]thiazol-2-ylimino)methyl)-5-methoxyphenol, C16H11F3N2O3S) and L4(2-((E)-(6-(trifluoromethoxy)benzo[d]thiazol-2-ylimino)methyl)-4-bromophenol, C15H8BrF3N2O2S) and their binary copper(II) complexes 1 [Cu(L1)2], 2 [Cu(L2)2], 3 [Cu(L3)2] and 4 [Cu(L4)2] have been synthesized and characterized by elemental analysis,1H NMR,13C NMR, ESI mass, FT-IR, ESR, UV-Visible, magnetic susceptibility, TGA, SEM and powder XRD studies. Based on spectral and analytical data, a square planar geometry is assigned for all Cu(II) complexes. The ligands and their Cu(II) complexes have been screened for antimicrobial activity against bacterial species E. coli, P. aeruginosa, B. amyloliquefaciens and S. aureus and fungal species S. rolfsii and M. phaseolina and it is observed that all Cu(II) complexes are more potent than corresponding ligands. DNA binding (UV absorption, fluorescence and viscosity titrations) and cleavage (oxidative and photo cleavage) studies of Cu(II) complexes have also been investigated against calf thymus DNA (CT-DNA) and supercoiled pBR322 DNA respectively. From the experimental results, it is found that the complexes bound effectively to CT-DNA through an intercalative mode and also cleaved pBR322 DNA in an efficient manner. The DNA binding and cleavage affinities of newly synthesized Cu(II) complexes are in the order of 2>1>3>4.
authors: Department of Chemistry, Osmania University, Hyderabad, Telangana 500007, India.
authors: Aveli
authors: A
authors: Rambabu
authors: Department of Chemistry, Osmania University, Hyderabad, Telangana 500007, India.
authors: Marri
authors: M
authors: Pradeep Kumar
authors: Department of Chemistry, Osmania University, Hyderabad, Telangana 500007, India.
authors: Somapangu
authors: S
authors: Tejaswi
authors: Department of Chemistry, Osmania University, Hyderabad, Telangana 500007, India.
authors: Narendrula
authors: N
authors: Vamsikrishna
authors: Department of Chemistry, Osmania University, Hyderabad, Telangana 500007, India. Electronic address: shivaraj_sunny@yahoo.co.in.
authors: Shivaraj
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D052160:Benzothiazoles / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D008024:Ligands; D008826:Microbial Sensitivity Tests; D012545:Schiff Bases / Q000737:chemistry*; D013057:Spectrum Analysis / Q000379:methods
chemical_list: D000890:Anti-Infective Agents; D052160:Benzothiazoles; D008024:Ligands; D012545:Schiff Bases; D003300:Copper; D004247:DNA
keywords: Antimicrobial activity; Binary Cu(II) complex; DNA interaction; Schiff base