title: Takotsubo cardiomyopathy with use of salbutamol nebulisation and aminophylline infusion in a patient with acute asthma exacerbation.
abstract: Takotsubo cardiomyopathy, apical ballooning syndrome or stress-induced cardiomyopathy is characterised by transient left ventricular dysfunction, mimicking myocardial infarction in the absence of obstructive coronary artery disease or acute plaque rupture on coronary angiography. The exact mechanism of myocardial dysfunction in Takotsubo cardiomyopathy is unknown; however, due to its association with physical and emotional stress, it is postulated that catecholamines play a central role in its pathogenesis. We present a case of a patient who was admitted with acute asthma exacerbation and was treated with β-2 agonist nebulisation and intravenous aminophylline. During her hospital stay she developed Takotsubo cardiomyopathy.
authors: Department of Medicine, The Aga Khan University Hospital, Karachi, Pakistan.
authors: Yousuf Hasan
authors: YH
authors: Khwaja
authors: Department of Medicine, The Aga Khan University Hospital, Karachi, Pakistan.
authors: Javed Majid
authors: JM
authors: Tai
mesh_terms: D000208:Acute Disease; D000280:Administration, Inhalation; D000420:Albuterol / Q000008:administration & dosage / Q000009:adverse effects*; D000628:Aminophylline / Q000008:administration & dosage / Q000009:adverse effects*; D001249:Asthma / Q000188:drug therapy*; D001993:Bronchodilator Agents / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008875:Middle Aged; D054549:Takotsubo Cardiomyopathy / Q000209:etiology*
chemical_list: D001993:Bronchodilator Agents; D000628:Aminophylline; D000420:Albuterol