title: Arterial Stiffness and Cardiovascular Autonomic Dysfunction in Patients with Parkinson's Disease.
abstract: Pulse wave velocity is a marker of arterial stiffness and a surrogate marker of vascular damage. Autonomic abnormalities associated with blood pressure are relatively commonly observed in patients with Parkinson's disease (PD).
  
  
  
  The purpose of this study was to compare arterial stiffness between patients with PD and controls and investigate the associations between cardiovascular autonomic dysfunction and pulse wave velocity in PD.
  
  
  
  One hundred twenty-five PD patients without diabetes mellitus were enrolled into this study, along with 22 age-matched controls. Orthostatic vital signs and ambulatory 24-hour blood pressure monitoring values were recorded. Pulse wave velocity was used to evaluate arterial stiffness.
  
  
  
  In PD, greater arterial stiffness was associated with orthostatic hypotension, supine hypertension, nocturnal hypertension, and nondipping. Dopaminergic treatment did not influence cardiovascular autonomic dysfunction or arterial stiffness. Although pulse wave velocity was mildly increased in patients with PD compared to controls, the arterial stiffness in PD patients without autonomic failure was similar to that in normal controls. Stiffer arteries were found only in patients with PD and autonomic failure.
  
  
  
  These findings suggest that cardiovascular autonomic dysfunction is associated with arterial stiffness in PD. PD itself does not affect arterial stiffness, whereas autonomic blood pressure disturbances influence alterations in arterial stiffness and architectural changes in the arteries of PD patients.
authors: Department of Neurology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors: Joong-Seok
authors: JS
authors: Kim
authors: Si-Hoon
authors: SH
authors: Lee
authors: Yoon-Sang
authors: YS
authors: Oh
authors: Jeong-Wook
authors: JW
authors: Park
authors: Jae-Young
authors: JY
authors: An
authors: Hyun-Seok
authors: HS
authors: Choi
authors: Kwang-Soo
authors: KS
authors: Lee
mesh_terms: D000368:Aged; D001341:Autonomic Nervous System / Q000503:physiopathology; D001342:Autonomic Nervous System Diseases / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D001794:Blood Pressure; D002319:Cardiovascular System / Q000503:physiopathology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000209:etiology; D007024:Hypotension, Orthostatic / Q000209:etiology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications* / Q000503:physiopathology; D063177:Pulse Wave Analysis; D016683:Supine Position; D059289:Vascular Stiffness