title: Acinetobacter baumannii Biofilm Formation in Human Serum and Disruption by Gallium.
abstract: Biofilm-associated infections caused by Acinetobacter baumannii are extremely recalcitrant to antibiotic treatment. We report that A. baumannii develops a mature biofilm when grown in complement-free human serum (HS). We demonstrate that 16 μM gallium nitrate (GaN) drastically reduces A. baumannii growth and biofilm formation in HS, whereas 64 μM GaN causes massive disruption of preformed A. baumannii biofilm. These findings pave the way to the repurposing of GaN as an antibiofilm agent for A. baumannii.
authors: Department of Sciences, University Roma Tre, Rome, Italy.
authors: Federica
authors: F
authors: Runci
authors: Department of Sciences, University Roma Tre, Rome, Italy.
authors: Carlo
authors: C
authors: Bonchi
authors: Department of Sciences, University Roma Tre, Rome, Italy.
authors: Emanuela
authors: E
authors: Frangipani
authors: Department of Sciences, University Roma Tre, Rome, Italy.
authors: Daniela
authors: D
authors: Visaggio
authors: Department of Sciences, University Roma Tre, Rome, Italy paolo.visca@uniroma3.it.
authors: Paolo
authors: P
authors: Visca
mesh_terms: D040981:Acinetobacter baumannii / Q000187:drug effects*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D018441:Biofilms / Q000187:drug effects*; D005708:Gallium / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests
chemical_list: D000900:Anti-Bacterial Agents; D005708:Gallium; C027235:gallium nitrate
keywords: Acinetobacter baumannii; biofilm; gallium; iron; iron metabolism; serum