title: Development of a microparticle-based dry powder inhalation formulation of ciprofloxacin hydrochloride applying the quality by design approach.
abstract: Pulmonary drug delivery of ciprofloxacin hydrochloride offers effective local antibacterial activity and convenience of easy application. Spray drying is a trustworthy technique for the production of ciprofloxacin hydrochloride microparticles. Quality by design (QbD), an up-to-date regulatory-based quality management method, was used to predict the final quality of the product. According to the QbD-based theoretical preliminary parameter ranking and priority classification, dry powder inhalation formulation tests were successfully performed in practice. When focusing on the critical parameters, the practical development was more effective and was in correlation with our previous findings. Spray drying produced spherical microparticles. The dry powder formulations prepared were examined by particle size analysis, scanning electron microscopy, Fourier-transform infrared spectroscopy, X-ray powder diffraction, differential scanning calorimetry, and in vitro drug release and aerodynamic particle size analyses were also performed. These formulations showed an appropriate particle size ranging between 2 and 4 μm and displayed an enhanced aerosol performance with fine particle fraction up to 80%.
authors: Faculty of Pharmacy, Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Szeged, Hungary.
authors: Keyhaneh
authors: K
authors: Karimi
authors: Faculty of Pharmacy, Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Szeged, Hungary.
authors: Edina
authors: E
authors: Pallagi
authors: Faculty of Pharmacy, Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Szeged, Hungary.
authors: Piroska
authors: P
authors: Szabó-Révész
authors: Faculty of Pharmacy, Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Szeged, Hungary.
authors: Ildikó
authors: I
authors: Csóka
authors: Faculty of Pharmacy, Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Szeged, Hungary.
authors: Rita
authors: R
authors: Ambrus
mesh_terms: D000280:Administration, Inhalation; D000336:Aerosols; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000737:chemistry* / Q000592:standards; D002152:Calorimetry, Differential Scanning; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000737:chemistry* / Q000592:standards; D018360:Crystallography, X-Ray; D003890:Desiccation; D004339:Drug Compounding; D058995:Dry Powder Inhalers; D005079:Excipients / Q000737:chemistry*; D007700:Kinetics; D008855:Microscopy, Electron, Scanning; D010316:Particle Size; D033362:Powder Diffraction; D011208:Powders; D011786:Quality Control; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties; D013678:Technology, Pharmaceutical / Q000379:methods* / Q000592:standards
chemical_list: D000336:Aerosols; D000900:Anti-Bacterial Agents; D005079:Excipients; D011208:Powders; D002939:Ciprofloxacin
keywords: aerodynamic evaluation; antibiotic; carrier-free formulation; dry powder for inhalation; quality by design