title: The Healing Cascade: Facilitating and Optimizing the System.
abstract: Healing is a complex process of orchestrated reactions and interactions with the goal of restoring structure and physical properties to damaged tissues. The musculoskeletal system is composed of different types of connective tissues. When healthy, each has a unique structure, function, and remodeling process. When damaged, they demonstrate unique healing processes. However, similarities in the process exist. Understanding these properties of healing is critical in the development and application of regenerative therapeutics. This article describes the common phases of healing, differences between healing in musculoskeletal tissues, factors that affect healing, and strategies to facilitate and optimize healing.
authors: Division of Rehabilitation Medicine, Weill Cornell Medical College, New York-Presbyterian Hospital, 525 East 68th Street, New York, NY 10065, USA.
authors: Ethan
authors: E
authors: Rand
authors: Division of Rehabilitation Medicine, Weill Cornell Medical College, New York-Presbyterian Hospital, 525 East 68th Street, New York, NY 10065, USA. Electronic address: alg9109@med.cornell.edu.
authors: Alfred C
authors: AC
authors: Gellhorn
mesh_terms: D006801:Humans; D009142:Musculoskeletal Physiological Phenomena; D012038:Regeneration; D014945:Wound Healing / Q000502:physiology*
keywords: Healing; Inflammation; Proliferation; Regeneration; Regenerative medicine; Remodeling; Repair