title: Influence of Body Mass Index on Hair Ethyl Glucuronide Concentrations.
abstract: OBJECTIVE
  Analysis of ethyl glucuronide (EtG) concentrations in hair is increasingly used to estimate the consumption of alcohol of the prior months. Linear correlations between the amount of alcohol consumed and the concentration of EtG in hair have been reported, and several variables that may influence this correlation have been investigated: e.g. cosmetic hair treatments, gender influences or hair color. Here, we investigate the influence of body mass index (BMI) on this correlation.
  
  
  METHODS
  A post hoc analysis on the influence of BMI on the relation between amounts of alcohol consumed and the measured EtG concentrations in hair in 199 participants.
  
  
  RESULTS
  Our data show higher EtG concentrations in participants with high BMI (≥25) compared to participants with low BMI (<25) (P = 0.001) across a wide range of amounts of alcohol consumed.
  
  
  CONCLUSIONS
  We conclude that BMI should be taken into account when interpreting hair EtG concentrations.
  
  
  OBJECTIVE
  Ethyl glucuronide concentrations in hair (hEtG) can be used to estimate the consumption of alcohol of the prior months. Body mass index (BMI) influences this relation and BMI should be taken into account when interpreting hEtG concentrations in participants with high BMI (≥25) compared to participants with low BMI (<25).
authors: Department of Pharmaceutical Sciences, Toxicological Center, University of Antwerp, Antwerp, Belgium cleo.crunelle@gmail.com.|Department of Psychiatry, University Hospital Brussels (UZ Brussel), Jette, Belgium.
authors: Cleo L
authors: CL
authors: Crunelle
authors: Department of Pharmaceutical Sciences, Toxicological Center, University of Antwerp, Antwerp, Belgium.|Toxicology and TDM Laboratory, ZNA Stuivenberg, Antwerp, Belgium.
authors: Hugo
authors: H
authors: Neels
authors: Department of Pharmaceutical Sciences, Toxicological Center, University of Antwerp, Antwerp, Belgium.
authors: Kristof
authors: K
authors: Maudens
authors: Toxicology and TDM Laboratory, ZNA Stuivenberg, Antwerp, Belgium.
authors: Mireille
authors: M
authors: De Doncker
authors: Department of Pharmaceutical Sciences, Toxicological Center, University of Antwerp, Antwerp, Belgium.
authors: Delphine
authors: D
authors: Cappelle
authors: Department of Psychiatry, University Hospital Brussels (UZ Brussel), Jette, Belgium.
authors: Frieda
authors: F
authors: Matthys
authors: Collaborative Antwerp Psychiatric Research Institute, University of Antwerp, Antwerp, Belgium.
authors: Geert
authors: G
authors: Dom
authors: StatUa Center for Statistics, University of Antwerp, Belgium.
authors: Erik
authors: E
authors: Fransen
authors: Department of Gastroenterology and Hepatology, University Hospital Antwerp, Antwerpen, Belgium.
authors: Peter
authors: P
authors: Michielsen
authors: Department of Pharmaceutical Sciences, Toxicological Center, University of Antwerp, Antwerp, Belgium.|Departement of Laboratory Medicine, AZ Alma, Eeklo, Belgium.
authors: Steven
authors: S
authors: De Keukeleire
authors: Department of Pharmaceutical Sciences, Toxicological Center, University of Antwerp, Antwerp, Belgium.
authors: Adrian
authors: A
authors: Covaci
authors: Laboratoire National de Santé, Service de Toxicologie, Dudelange, Luxembourg.
authors: Michel
authors: M
authors: Yegles
mesh_terms: D000328:Adult; D064829:Alcohol Abstinence; D000428:Alcohol Drinking / Q000378:metabolism*; D000437:Alcoholism / Q000175:diagnosis / Q000378:metabolism*; D015415:Biomarkers / Q000032:analysis / Q000737:chemistry / Q000378:metabolism; D015992:Body Mass Index; D005260:Female; D005965:Glucuronates / Q000032:analysis* / Q000378:metabolism; D006197:Hair / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D015415:Biomarkers; D005965:Glucuronates; C093924:ethyl glucuronide