title: Methotrexate hypersensitivity reactions in pediatrics: Evaluation and management.
abstract: Reports of hypersensitivity reactions (HSRs) to MTX are limited to single case studies. We retrospectively reviewed HSRs to MTX during a 12-year period in our tertiary care pediatric center. Seven patients were evaluated for HSRs to MTX. Skin testing was positive in one of the four patients tested. One patient underwent successful graded challenge to MTX. Seventeen desensitizations to MTX were successfully performed in the other six patients. Skin testing, graded challenge, and desensitization were safe and effective procedures in the evaluation and management of patients with HSRs to MTX in our pediatric population.
authors: Division of Immunology at Boston Children's Hospital, Boston, Massachusetts.|Department of Pharmacy at Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.
authors: Meredith A
authors: MA
authors: Dilley
authors: Division of Immunology at Boston Children's Hospital, Boston, Massachusetts.
authors: Joyce P
authors: JP
authors: Lee
authors: Division of Immunology at Boston Children's Hospital, Boston, Massachusetts.|Department of Pharmacy at Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.
authors: Ana Dioun
authors: AD
authors: Broyles
mesh_terms: D003888:Desensitization, Immunologic / Q000379:methods*; D004342:Drug Hypersensitivity / Q000175:diagnosis* / Q000276:immunology*; D006801:Humans; D008727:Methotrexate / Q000276:immunology*; D012189:Retrospective Studies; D012882:Skin Tests
chemical_list: D008727:Methotrexate
keywords: chemotherapy; desensitization; drug allergy; methotrexate