title: Nodule Regression in Adults With Nodular Gastritis.
abstract: BACKGROUND
  Nodular gastritis (NG) is associated with the presence ofHelicobacter pyloriinfection, but there are controversies on nodule regression in adults. The aim of this study was to analyze the factors that are related to the nodule regression in adults diagnosed as NG.
  
  
  METHODS
  Adult population who were diagnosed as NG withH. pyloriinfection during esophagogastroduodenoscopy (EGD) at our center were included. Changes in the size and location of the nodules, status ofH. pyloriinfection, upper gastrointestinal (UGI) symptom, EGD and pathology findings were analyzed between the initial and follow-up tests.
  
  
  RESULTS
  Of the 117 NG patients, 66.7% (12/18) of the eradicated NG patients showed nodule regression afterH. pylorieradication, whereas 9.9% (9/99) of the non-eradicated NG patients showed spontaneous nodule regression withoutH. pylorieradication (P < 0.001). Nodule regression was more frequent in NG patients with antral nodule location (P = 0.010), small-sized nodules (P = 0.029),H. pylorieradication (P < 0.001), UGI symptom (P = 0.007), and a long-term follow-up period (P = 0.030). On the logistic regression analysis, nodule regression was inversely correlated with the persistentH. pyloriinfection on the follow-up test (odds ratio (OR): 0.020, 95% confidence interval (CI): 0.003 - 0.137, P < 0.001) and short-term follow-up period < 30.5 months (OR: 0.140, 95% CI: 0.028 - 0.700, P = 0.017).
  
  
  CONCLUSIONS
  In adults with NG,H. pylorieradication is the most significant factor associated with nodule regression. Long-term follow-up period is also correlated with nodule regression, but is less significant thanH. pylorieradication. Our findings suggest thatH. pylorieradication should be considered to promote nodule regression in NG patients withH. pyloriinfection.
authors: Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea.
authors: Ji Wan
authors: JW
authors: Kim
authors: Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea.
authors: Sun-Young
authors: SY
authors: Lee
authors: Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea.
authors: Jeong Hwan
authors: JH
authors: Kim
authors: Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea.
authors: In-Kyung
authors: IK
authors: Sung
authors: Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea.
authors: Hyung Seok
authors: HS
authors: Park
authors: Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea.
authors: Chan-Sup
authors: CS
authors: Shim
authors: Department of Pathology, Konkuk University School of Medicine, Seoul, Korea.
authors: Hye Seung
authors: HS
authors: Han
keywords: Eradication; Gastritis; Helicobacter pylori; Nodule; Regression