title: A case of relapsing encephalitis positive for gamma aminobutyric acid (GABA)Areceptor antibody associated with Type B3 thymoma.
abstract: A 87-year-old female presented with subacute progression of cognitive decline. Fluid-attenuated inversion recovery images of brain MRI showed multifocal high-intensity lesions. Thoracic CT image revealed the presence of thymoma, and serum autoantibody screening showed positivity for anti-gamma aminobutyric acid (GABA)Areceptor antibody. Histopathological analysis confirmed type B3 thymoma after thymectomy. The patient received both plasmapheresis and intravenous methylprednisolone therapy, and showed remarkable amelioration of clinical symptoms and MRI abnormal high intensity. However, after 2 month from the clinical recovery, the patient showed recurrence of brain lesions and intravenous methylprednisolone monotherapy was performed. Continuation of oral steroid therapy was required to maintain the quienscent state of inflammation within the central nervous system. Anti-GABAAreceptor antibody is a recently discovered novel autoantibody associated with autoimmue encephalitis. Due to the limited number of literature reported, clinical course and therapeutic response of GABAAreceptor antibody encephalitis remains elusive. Here we reported a rare case of GABAAreceptor antibody encephalitis with type B3 thymoma. Clinical, radiological and therapeutic courses described in our report highlight the importance of immunotherapy for treatment of the disease.
authors: Department of Neurology, Osaka General Medical Center.
authors: Takaya
authors: T
authors: Kitano
authors: Makoto
authors: M
authors: Kinoshita
authors: Kohki
authors: K
authors: Shimazu
authors: Hiroaki
authors: H
authors: Fushimi
authors: Kenichi
authors: K
authors: Omori
authors: Takanori
authors: T
authors: Hazama
mesh_terms: D000369:Aged, 80 and over; D001323:Autoantibodies / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D004660:Encephalitis / Q000175:diagnosis* / Q000209:etiology* / Q000628:therapy; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008775:Methylprednisolone / Q000008:administration & dosage; D010951:Plasma Exchange; D020551:Pulse Therapy, Drug; D011963:Receptors, GABA-A / Q000276:immunology*; D012008:Recurrence; D013934:Thymectomy; D013945:Thymoma / Q000150:complications* / Q000175:diagnosis* / Q000628:therapy; D013953:Thymus Neoplasms / Q000150:complications* / Q000175:diagnosis* / Q000628:therapy; D014057:Tomography, X-Ray Computed
chemical_list: D001323:Autoantibodies; D015415:Biomarkers; D011963:Receptors, GABA-A; D008775:Methylprednisolone