title: Modulation of host signaling in the inflammatory response by enteropathogenic Escherichia coli virulence proteins.
abstract: To successfully infect host cells and evade the host immune response, a type III secretion system (T3SS) is commonly used by enteric bacterial pathogens such as enteropathogenic Escherichia coli (EPEC). Recent findings have revealed that various effectors are injected into host cells through the T3SS and exert an inhibitory effect on inflammatory signaling pathways, subverting the immune responses to these pathogens. Here we review recent studies aimed at addressing the modulation of several important inflammatory signaling pathways modulated by EPEC effector proteins, such as the nuclear factor-κB (NF-κB) and mitogen-activated protein kinase (MAPK) pathways, which provides insight into the unfinished work in this unexplored field and helps to identify novel positions in inflammatory signaling networks for EPEC effectors.Cellular & Molecular Immunology advance online publication, 31 October 2016; doi:10.1038/cmi.2016.52.
authors: Department of Immunology and Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.
authors: Xiaonan
authors: X
authors: Zhuang
authors: Department of Immunology and Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.
authors: Zijuan
authors: Z
authors: Chen
authors: Department of Microbiology and Immunology, Tongji University School of Medicine, Shanghai 200092, China.
authors: Chenxi
authors: C
authors: He
authors: Department of Microbiology and Immunology, Tongji University School of Medicine, Shanghai 200092, China.
authors: Lin
authors: L
authors: Wang
authors: Department of Immunology and Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.
authors: Ruixue
authors: R
authors: Zhou
authors: Department of Immunology and Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.
authors: Dapeng
authors: D
authors: Yan
authors: Department of Microbiology and Immunology, Tongji University School of Medicine, Shanghai 200092, China.|Shanghai Key Laboratory of Tuberculosis, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200092, China.
authors: Baoxue
authors: B
authors: Ge
mesh_terms: D000818:Animals; D054308:Enteropathogenic Escherichia coli / Q000472:pathogenicity*; D029968:Escherichia coli Proteins / Q000378:metabolism*; D054884:Host-Pathogen Interactions / Q000276:immunology*; D006801:Humans; D007249:Inflammation / Q000382:microbiology* / Q000473:pathology; D015398:Signal Transduction; D037521:Virulence Factors / Q000378:metabolism*
chemical_list: D029968:Escherichia coli Proteins; D037521:Virulence Factors