title: Endoluminal Therapy for Gastroesophageal Reflux Disease: In Between the Pill and the Knife?
abstract: Gastroesophageal reflux disease (GERD) is a chronic disease characterized by symptoms of heartburn and acid regurgitation. Uncontrolled GERD can significantly impact quality of life, can lead to complications, and increases the risk of esophageal cancer. Over the past few decades, there has been an increasing prevalence of GERD among adults in Western populations. The use of proton pump inhibitors (PPI) in conjunction with lifestyle modifications remains the mainstay therapy. However, the efficacy of this intervention is often hampered by adherence, costs, and the risks of long-term PPI use. Anti-reflux surgery is an option for patients with refractory symptoms or in those in whom medical therapy is contraindicated or not desirable. While conventional surgery has an acceptable safety profile, there has been an increasing interest in alternate treatments that may potentially offer similar results and be associated with a faster recovery. Recent advances in interventional endoluminal techniques have introduced novel incisionless anti-reflux procedures. While the current data are promising, further larger prospective studies are needed in order to assess the long-term efficacy of endoluminal therapies and its place among the treatment options for GERD.
authors: Department of Medicine, University of Florida, Gainesville, FL, USA.
authors: Tony S
authors: TS
authors: Brar
authors: Division of Gastroenterology, Hepatology and Nutrition, University of Florida, 1329 SW 16th Street, Room #5251, Gainesville, FL, 32608, USA.
authors: Peter V
authors: PV
authors: Draganov
authors: Division of Gastroenterology, Hepatology and Nutrition, University of Florida, 1329 SW 16th Street, Room #5251, Gainesville, FL, 32608, USA. dennis.yang@medicine.ufl.edu.
authors: Dennis
authors: D
authors: Yang
mesh_terms: D017115:Catheter Ablation; D003680:Deglutition Disorders; D049630:Esophageal Sphincter, Lower / Q000601:surgery*; D004945:Esophagoscopy; D005247:Feeding Behavior; D018662:Fundoplication; D005764:Gastroesophageal Reflux / Q000628:therapy*; D005773:Gastroscopy; D006551:Hernia, Hiatal; D006635:Histamine H2 Antagonists / Q000627:therapeutic use; D006801:Humans; D007267:Injections; D010535:Laparoscopy; D059346:Magnets; D010349:Patient Compliance; D011183:Postoperative Complications; D054328:Proton Pump Inhibitors / Q000627:therapeutic use; D016540:Smoking Cessation; D015431:Weight Loss
chemical_list: D006635:Histamine H2 Antagonists; D054328:Proton Pump Inhibitors
keywords: Endoluminal anterior fundoplication; Endoluminal therapy; Gastroesophageal reflux disease; Proton pump inhibitors; Radiofrequency ablation; Transoral incisionless fundoplication