title: Structural and functional analogies and differences between histidine decarboxylase and aromatic l-amino acid decarboxylase molecular networks: Biomedical implications.
abstract: Human histidine decarboxylase (HDC) and dopa decarboxilase (DDC) are highly homologous enzymes responsible for the synthesis of biogenic amines (BA) like histamine, and serotonin and dopamine, respectively. The enzymes share many structural and functional analogies, while their product metabolisms also follow similar patterns that are confluent in some metabolic steps. They are involved in common physiological functions, such as neurotransmission, gastrointestinal track function, immunity, cell growth and cell differentiation. As a consequence, metabolic elements of both BA subfamilies are also co-participants in a long list of human diseases. This review summarizes the analogies and differences in their origin (HDC and DDC) as well as their common pathophysiological scenarios. The major gaps of information are also underlined, as they delay the possibility of holistic approaches that would help personalized medicine and pharmacological initiatives for prevalent and rare diseases.
authors: Departamento de Biología Molecular y Bioquímica. Facultad de Ciencias, Universidad de Málaga, Spain; Centro de Investigación en red en Enfermedades Raras (ISCIII), 29071 Málaga, Spain. Electronic address: kika@uma.es.
authors: Francisca
authors: F
authors: Sanchez-Jiménez
authors: Department of Chemistry, The City College of New York, New York, NY 10031, USA.
authors: Almudena
authors: A
authors: Pino-Ángeles
authors: Departamento de Biología Molecular y Bioquímica. Facultad de Ciencias, Universidad de Málaga, Spain.
authors: Rocio
authors: R
authors: Rodríguez-López
authors: Departamento de Biología Molecular y Bioquímica. Facultad de Ciencias, Universidad de Málaga, Spain.
authors: María
authors: M
authors: Morales
authors: Departamento de Biología Molecular y Bioquímica. Facultad de Ciencias, Universidad de Málaga, Spain; Centro de Investigación en red en Enfermedades Raras (ISCIII), 29071 Málaga, Spain.
authors: José Luis
authors: JL
authors: Urdiales
mesh_terms: D000818:Animals; D001142:Aromatic-L-Amino-Acid Decarboxylases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism; D006632:Histamine / Q000378:metabolism; D006640:Histidine Decarboxylase / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008958:Models, Molecular; D035583:Rare Diseases / Q000235:genetics / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism
chemical_list: D012701:Serotonin; D006632:Histamine; D006640:Histidine Decarboxylase; D001142:Aromatic-L-Amino-Acid Decarboxylases; D004298:Dopamine
keywords: Dopamine; Histamine; Molecular interactions; Orphan diseases; Serotonin; Systems pharmacology