title: Telocytes: New Players in Gallstone Disease.
abstract: Cholesterol gallstone disease is highly prevalent in Western countries, particularly in women and some specific ethnic groups. The mechanisms behind the formation of gallstones are not clearly understood, but gallbladder dysmotility seems to be a key factor that triggers the precipitation of cholesterol microcrystals from supersaturated lithogenic bile.Given that newly described interstitial cells, telocytes, are present in the gallbladder and they are located in close vicinity of smooth muscle cell and neural fibers possibly interfering with gallbladder motility or contractility, authors are trying to summarize the current knowledge on the role of telocytes with respect to disturbed gallbladder function in gallstone disease.
authors: First Department of General, Oncological and Gastrointestinal Surgery, Jagiellonian University Medical College, 40 Kopernika St., 31-501, Krakow, Poland. artur.pasternak@uj.edu.pl.|Department of Anatomy, Jagiellonian University Medical College, 12 Kopernika St., 31-034, Krakow, Poland. artur.pasternak@uj.edu.pl.
authors: Artur
authors: A
authors: Pasternak
authors: Department of Pathophysiology, Jagiellonian University Medical College, 18 Czysta St., 31-121, Krakow, Poland.
authors: Krzysztof
authors: K
authors: Gil
authors: First Department of General, Oncological and Gastrointestinal Surgery, Jagiellonian University Medical College, 40 Kopernika St., 31-501, Krakow, Poland.
authors: Andrzej
authors: A
authors: Matyja
mesh_terms: D001315:Australia / Q000453:epidemiology; D001646:Bile / Q000737:chemistry / Q000378:metabolism; D001647:Bile Acids and Salts / Q000737:chemistry* / Q000378:metabolism; D002784:Cholesterol / Q000737:chemistry* / Q000378:metabolism; D005060:Europe / Q000453:epidemiology; D005260:Female; D005704:Gallbladder / Q000378:metabolism / Q000473:pathology*; D042882:Gallstones / Q000453:epidemiology* / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D008297:Male; D009119:Muscle Contraction; D032389:Myocytes, Smooth Muscle / Q000378:metabolism / Q000473:pathology; D009413:Nerve Fibers, Myelinated / Q000378:metabolism / Q000473:pathology; D009656:North America / Q000453:epidemiology; D015995:Prevalence; D012737:Sex Factors; D000067170:Telocytes / Q000378:metabolism / Q000473:pathology*
chemical_list: D001647:Bile Acids and Salts; D002784:Cholesterol
keywords: Bile lithogenicity; Cholesterol saturation index; Gallstone disease; Telocytes