title: Increased cerebral blood flow among adolescents with bipolar disorder at rest is reduced following acute aerobic exercise.
abstract: Cerebral blood flow (CBF) is altered in mood disorders but has not been examined among adolescents with bipolar disorder (BD). Similarly, little is known about the acute neurophysiologic effects of aerobic exercise in BD. We therefore compared CBF between adolescents with and without BD at rest and acutely following a single exercise session.
  
  
  
  Thirty-one adolescents with BD and 20 age and sex-matched controls participated in this study. CBF magnetic resonance images (MRI) were acquired using arterial spin labeling at a baseline as well as 15 and 45min after a single 20-min session of recumbent cycling. Voxel-based CBF analyses compared groups at baseline and after exercise. Clinical, body mass index (BMI) and exercise-induced feelings inventory (EFI) data were examined for their influence on CBF findings.
  
  
  
  Baseline CBF was increased in medial frontal and middle cingulate regions in BD compared to controls. Analysis of the acute CBF changes revealed pronounced exercise-related decreases in CBF in BD. Exercise-related feelings of exhaustion were associated with CBF changes in frontal but not parietal regions.
  
  
  
  A single bout of moderate-intensity aerobic exercise reduced regional CBF to a greater extent in BD compared to controls; these time dependent CBF responses were associated with exercise-induced feelings of exhaustion.
authors: Heart and Stroke Foundation Canadian Partnership for Stroke Recovery, Sunnybrook Research Institute, Toronto, ON, Canada; Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada. Electronic address: bmac@sri.utoronto.ca.
authors: Bradley J
authors: BJ
authors: MacIntosh
authors: Heart and Stroke Foundation Canadian Partnership for Stroke Recovery, Sunnybrook Research Institute, Toronto, ON, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
authors: Zahra
authors: Z
authors: Shirzadi
authors: Psychiatry, Sunnybrook Research Institute, Toronto, ON, Canada.
authors: Antonette
authors: A
authors: Scavone
authors: Heart and Stroke Foundation Canadian Partnership for Stroke Recovery, Sunnybrook Research Institute, Toronto, ON, Canada; Psychiatry, Sunnybrook Research Institute, Toronto, ON, Canada.
authors: Arron Ws
authors: AW
authors: Metcalfe
authors: Psychiatry, Sunnybrook Research Institute, Toronto, ON, Canada.
authors: Alvi H
authors: AH
authors: Islam
authors: Department of Psychiatry, Hospital for Sick Children, Toronto, Canada.
authors: Daphne
authors: D
authors: Korczak
authors: Heart and Stroke Foundation Canadian Partnership for Stroke Recovery, Sunnybrook Research Institute, Toronto, ON, Canada; Psychiatry, Sunnybrook Research Institute, Toronto, ON, Canada.
authors: Benjamin I
authors: BI
authors: Goldstein
mesh_terms: D000293:Adolescent; D001714:Bipolar Disorder / Q000503:physiopathology*; D016022:Case-Control Studies; D015444:Exercise / Q000502:physiology*; D005260:Female; D006179:Gyrus Cinguli / Q000098:blood supply*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D059906:Neuroimaging; D012146:Rest / Q000502:physiology*; D013113:Spin Labels
chemical_list: D013113:Spin Labels
keywords: Acute aerobic exercise; Adolescent; Arterial spin labeling; Bipolar disorder; Cerebral blood flow; Exercise-induced feelings inventory