title: Piceatannol Exerts Anti-Obesity Effects in C57BL/6 Mice through Modulating Adipogenic Proteins and Gut Microbiota.
abstract: Obesity is a global health concern. Piceatannol (Pic), an analog of resveratrol (Res), has many reported biological activities. In this study, we investigated the anti-obesity effect of Pic in a high-fat diet (HFD)-induced obese animal model. The results showed that Pic significantly reduced mouse body weight in a dose-dependent manner without affecting food intake. Serum total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL) levels, and blood glucose (GLU) were significantly lowered in Pic-treated groups. Pic significantly decreased the weight of liver, spleen, perigonadal and retroperitoneal fat compared with the HFD group. Pic significantly reduced the adipocyte cell size of perigonadal fat and decreased the weight of liver. Pic-treated mice showed higher phosphorylated adenosine 5'-monophosphate-activated protein kinase (pAMPK) and phosphorylated acetyl-CoA carboxylase (pACC) protein levels and decreased protein levels of CCAAT/enhancer-binding protein C/EBPα, peroxisome proliferator-activated receptor PPARγ and fatty acid synthase (FAS), resulting in decreased lipid accumulation in adipocytes and the liver. Pic altered the composition of the gut microbiota by increasing Firmicutes andLactobacillusand decreasing Bacteroidetes compared with the HFD group. Collectively, these results suggest that Pic may be a candidate for obesity treatment.
authors: Institute of Food Sciences and Technology, National Taiwan University, Taipei 10617, Taiwan. emjine@gmail.com.
authors: Yen-Chen
authors: YC
authors: Tung
authors: Institute of Food Sciences and Technology, National Taiwan University, Taipei 10617, Taiwan. gloomy-trf@hotmail.com.
authors: Yu-Hsuan
authors: YH
authors: Lin
authors: Institute of Food Sciences and Technology, National Taiwan University, Taipei 10617, Taiwan. fsthjchen@ntu.edu.tw.
authors: Hong-Jhang
authors: HJ
authors: Chen
authors: Department of Biological Science & Technology, China Medical University, Taichung 40402, Taiwan. shenchieh.chou@gmail.com.
authors: Shen-Chieh
authors: SC
authors: Chou
authors: Department of Tourism, Food and Beverage Management, Chang Jung Christian University, Tainan 71101, Taiwan. anniecheng@mail.cjcu.edu.tw.
authors: An-Chin
authors: AC
authors: Cheng
authors: Sabinsa Corporation, East Windsor, NJ 08520, USA. kalyanam@sabinsa.com.
authors: Nagabhushanam
authors: N
authors: Kalyanam
authors: Department of Food Science, Rutgers University, New Brunswick, NJ 08901, USA. ho@aesop.rutgers.edu.
authors: Chi-Tang
authors: CT
authors: Ho
authors: Institute of Food Sciences and Technology, National Taiwan University, Taipei 10617, Taiwan. mhpan@ntu.edu.tw.|Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 40402, Taiwan. mhpan@ntu.edu.tw.|Department of Health and Nutrition Biotechnology, Asia University, Taichung 41354, Taiwan. mhpan@ntu.edu.tw.
authors: Min-Hsiung
authors: MH
authors: Pan
mesh_terms: D050156:Adipogenesis / Q000187:drug effects*; D000818:Animals; D019440:Anti-Obesity Agents / Q000008:administration & dosage* / Q000494:pharmacology; D001835:Body Weight / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D059305:Diet, High-Fat / Q000009:adverse effects*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects; D000069196:Gastrointestinal Microbiome / Q000187:drug effects*; D005786:Gene Expression Regulation / Q000187:drug effects; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D051379:Mice; D008810:Mice, Inbred C57BL; D009765:Obesity / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D009929:Organ Size / Q000187:drug effects; D013267:Stilbenes / Q000008:administration & dosage* / Q000494:pharmacology
chemical_list: D019440:Anti-Obesity Agents; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D013267:Stilbenes; C041525:3,3',4,5'-tetrahydroxystilbene; D002784:Cholesterol
keywords: AMPK; C57BL/6; gut microbiota; high-fat diet; obesity; piceatannol