title: Non-invasive diagnosis of hepatic steatosis.
abstract: Non-invasive diagnosis and quantification of hepatic steatosis rely on two different but complementary approaches: biomarkers or imaging techniques, either ultrasound-based such as liver ultrasonography and controlled attenuation parameter (CAP), or computed tomography (CT) and magnetic resonance imaging (MRI). Scores for the detection of steatosis have not gained much popularity in clinical practice so far. CAP, using the M probe, is the most promising technique but needs to be implemented with the XL probe and compared to ultrasound that, despite its limitations, remains the most widely used method. CT, owing to its low sensitivity and the fact that it involves a potential radiation hazard, is inappropriate. Finally, proton density fat fraction measurement by MRI is currently the most accurate and sensitive imaging method, simpler and more practical than magnetic resonance spectroscopy, but restricted, up to now, just to research and clinical trials.
authors: Service d'Hépatologie, Hôpital Beaujon, 100 Boulevard du Général Leclerc, 92110, Clichy, France.
authors: Christiane
authors: C
authors: Stern
authors: Service d'Hépatologie, Hôpital Beaujon, Assistance Publique-Hôpitaux de Paris, INSERM UMR 1148, CRI, Université Paris Diderot, Clichy, France. laurent.castera@aphp.fr.
authors: Laurent
authors: L
authors: Castera
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D005234:Fatty Liver / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D064847:Multimodal Imaging / Q000379:methods; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography
chemical_list: D015415:Biomarkers
keywords: Biomarkers; NAFLD; NASH; Non-invasive tests; Steatosis