title: Computed Optical Interferometric Imaging: Methods, Achievements, and Challenges.
abstract: Three-dimensional high-resolution optical imaging systems are generally restricted by the trade-off between resolution and depth-of-field as well as imperfections in the imaging system or sample. Computed optical interferometric imaging is able to overcome these longstanding limitations using methods such as interferometric synthetic aperture microscopy (ISAM) and computational adaptive optics (CAO) which manipulate the complex interferometric data. These techniques correct for limited depth-of-field and optical aberrations without the need for additional hardware. This paper aims to outline these computational methods, making them readily available to the research community. Achievements of the techniques will be highlighted, along with past and present challenges in implementing the techniques. Challenges such as phase instability and determination of the appropriate aberration correction have been largely overcome so that imaging of living tissues using ISAM and CAO is now possible. Computed imaging in optics is becoming a mature technology poised to make a significant impact in medicine and biology.
authors: Beckman Institute for Advanced Science and Technology, also with the Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801 USA.
authors: Fredrick A
authors: FA
authors: South
authors: Beckman Institute for Advanced Science and Technology, also with the Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801 USA.
authors: Yuan-Zhi
authors: YZ
authors: Liu
authors: Beckman Institute for Advanced Science and Technology, also with the Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801 USA.
authors: P Scott
authors: PS
authors: Carney
authors: Beckman Institute for Advanced Science and Technology, also with the Departments of Electrical and Computer Engineering, Bioengineering, and Internal Medicine, University of Illinois at Urbana-Champaign, Urbana, IL 61801 USA.
authors: Stephen A
authors: SA
authors: Boppart
keywords: Adaptive optics; biomedical optical imaging; computed imaging; high-resolution imaging; optical coherence tomography; synthetic aperture