title: In Situ Ion-Transmission Mass Spectrometry for Paper-Based Analytical Devices.
abstract: Current detection methods for paper-based analytical devices (PADs) rely on spectroscopic and electrochemical properties, which place special requirements on the analyte or need analyte labeling. Here, ion-transmission mass spectrometry (MS) was proposed for coupling with PADs to enable rapid in situ MS analysis of the sample on paper. The sample was analyzed directly on paper via analyte ionization by ions transmitted through the paper, generated by a low-temperature plasma probe. Prior to MS analysis, the sample can be separated by paper electrophoresis or by paper chromatography, among a variety of other features offered by PADs. The versatility of this technique was demonstrated by MS analysis of a paper microarray, a mixture of amino acids, and whole blood doped with drugs on PADs.
authors: Department of Chemistry, Tsinghua University , Beijing 100084, P.R. China.
authors: Yaoyao
authors: Y
authors: Zhao
authors: Department of Chemistry, Tsinghua University , Beijing 100084, P.R. China.
authors: Zhenwei
authors: Z
authors: Wei
authors: Department of Chemistry, Tsinghua University , Beijing 100084, P.R. China.
authors: Hansen
authors: H
authors: Zhao
authors: Department of Chemistry, Tsinghua University , Beijing 100084, P.R. China.
authors: Jia
authors: J
authors: Jia
authors: Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Shandong Normal University , Jinan 250014, P.R. China.
authors: Zhenzhen
authors: Z
authors: Chen
authors: Department of Chemistry, Tsinghua University , Beijing 100084, P.R. China.
authors: Sichun
authors: S
authors: Zhang
authors: Department of Precision Instrument, Tsinghua University , Beijing 100084, P.R. China.
authors: Zheng
authors: Z
authors: Ouyang
authors: Department of Precision Instrument, Tsinghua University , Beijing 100084, P.R. China.
authors: Xiaoxiao
authors: X
authors: Ma
authors: Department of Chemistry, Tsinghua University , Beijing 100084, P.R. China.
authors: Xinrong
authors: X
authors: Zhang
mesh_terms: D000596:Amino Acids / Q000032:analysis*; D013058:Mass Spectrometry / Q000379:methods*; D015335:Molecular Probes / Q000737:chemistry*; D010209:Paper; D013696:Temperature
chemical_list: D000596:Amino Acids; D015335:Molecular Probes