title: The Effect of Zinc and Selenium Supplementation Mode on Their Bioavailability in the Rat Prostate. Should Administration Be Joint or Separate?
abstract: It is thought that zinc and selenium deﬁciency may play a signiﬁcant role in the etiology of prostate cancer. Although joint zinc and selenium supplementation is frequently applied in the prevention of prostate diseases, the bioavailability of these elements in the prostate after co-administration is still unknown. The study examines the effect of subchronic supplementation of zinc gluconate and selenium compounds (sodium selenite or selenomethionine), administered together or separately, on their bioavailability in the prostate, as well as the induction of metallothionein-like proteins (MTs) bound to zinc in the prostate and liver. Zinc concentration in the dorso-lateral lobe of the prostate was signiﬁcantly elevated already after the ﬁrst month of supplementation of zinc alone. In the supplementation period, the MTs level increased together with zinc concentration. In contrast, the ventral lobe of the prostate did not demonstrate signiﬁcantly higher levels of zinc until after three months of supplementation, despite the MTs induction noted after one-month supplementation. Increased selenium levels in the dorsolateral lobe were observed throughout the administration and post-administration periods, regardless of the selenium compound used or whether zinc was co-administered. The results of our studies suggested for the ﬁrst time that these elements should not be administered jointly in supplementation.
authors: Department of Toxicology, Faculty of Pharmacy, Medical University of Lodz, Muszynskiego 1, 90-151 Lodz, Poland. adam.darago@umed.lodz.pl.
authors: Adam
authors: A
authors: Daragó
authors: Department of Toxicology, Faculty of Pharmacy, Medical University of Lodz, Muszynskiego 1, 90-151 Lodz, Poland. andrzej.sapota@umed.lodz.pl.
authors: Andrzej
authors: A
authors: Sapota
authors: Department of Toxicology, Faculty of Pharmacy, Medical University of Lodz, Muszynskiego 1, 90-151 Lodz, Poland. marzenna.nasiadek@umed.lodz.pl.
authors: Marzenna
authors: M
authors: Nasiadek
authors: Department of Toxicology, Faculty of Pharmacy, Medical University of Lodz, Muszynskiego 1, 90-151 Lodz, Poland. michal.klimczak@umed.lodz.pl.
authors: Michał
authors: M
authors: Klimczak
authors: Department of Toxicology, Faculty of Pharmacy, Medical University of Lodz, Muszynskiego 1, 90-151 Lodz, Poland. anna.kilanowicz@umed.lodz.pl.
authors: Anna
authors: A
authors: Kilanowicz
mesh_terms: D000818:Animals; D001682:Biological Availability; D019587:Dietary Supplements; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005942:Gluconates / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008297:Male; D011467:Prostate / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D012645:Selenomethionine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D018038:Sodium Selenite / Q000008:administration & dosage / Q000493:pharmacokinetics*
chemical_list: D005942:Gluconates; D012645:Selenomethionine; D018038:Sodium Selenite; C030691:gluconic acid
keywords: metallothionein-like proteins; prostate; rats; selenomethionine; sodium selenite; supplementation; zinc gluconate