title: Mechanisms and Mediators of the Skeletal Muscle Repeated Bout Effect.
abstract: Skeletal muscle adapts to exercise-induced damage by orchestrating several but still poorly understood mechanisms that endow protection from subsequent damage. Known widely as the repeated bout effect, we propose that neural adaptations, alterations to muscle mechanical properties, structural remodeling of the extracellular matrix, and biochemical signaling work in concert to coordinate the protective adaptation.
authors: 1Department of Exercise Sciences, Brigham Young University, Provo, UT; 2Department of Physical Education, National Taiwan Normal University, Taipei City, Taiwan; and 3Centre for Exercise and Sports Sciences, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia.
authors: Robert D
authors: RD
authors: Hyldahl
authors: Trevor C
authors: TC
authors: Chen
authors: Kazunori
authors: K
authors: Nosaka
mesh_terms: D000222:Adaptation, Physiological; D001696:Biomechanical Phenomena; D015444:Exercise / Q000502:physiology*; D005109:Extracellular Matrix / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D009046:Motor Neurons / Q000502:physiology; D018482:Muscle, Skeletal / Q000293:injuries* / Q000294:innervation / Q000502:physiology*; D013710:Tendons / Q000502:physiology