title: Gold nanoprism-nanorod face off: comparing the heating efficiency, cellular internalization and thermoablation capacity.
abstract: OBJECTIVE
  This work compares the synthesis, heating capability, cellular internalization and thermoablation capacity of two different types of anisotropic gold nanoparticles: gold nanorods (NRs) and nanoprisms (NPrs).
  
  
  METHODS
  Both particles possess surface plasmon resonance absorption bands in the near-IR, and their heating efficiency upon irradiation with a continuous near-IR laser (1064 nm) was evaluated. The cellular internalization, location and toxicity of these PEG-stabilized NPrs and NRs were then assessed in the Vero cell line by transmission electron microscopy and inductively coupled plasma mass spectrometry analysis, and their ability to induce cell death upon laser irradiation was then evaluated and compared.
  
  
  CONCLUSIONS
  Although both nanoparticles are highly efficient photothermal converters, NRs possessed a more efficient heating capability, yet the in vitro thermoablation studies clearly demonstrated that NPrs were more effective at inducing cell death through photothermal ablation due to their greater cellular internalization.
authors: Institute of Nano Biomedicine and Engineering, Key Laboratory for Thin Film & Microfabrication Technology of the Ministry of Education, Shanghai Jiao Tong University, 200240-Shanghai, PR China.|Instituto de Ciencia de Materiales de Aragón (ICMA-CSIC), Universidad de Zaragoza, 50009-Zaragoza, Spain.
authors: Gabriel
authors: G
authors: Alfranca
authors: Instituto de Ciencia de Materiales de Aragón (ICMA-CSIC), Universidad de Zaragoza, 50009-Zaragoza, Spain.
authors: Álvaro
authors: Á
authors: Artiga
authors: Instituto de Nanociencia de Aragón, Universidad de Zaragoza, 50018-Zaragoza, Spain.
authors: Grazyna
authors: G
authors: Stepien
authors: Istituto di Scienze Applicate e Sistemi Intelligenti 'Eduardo Caianiello,' 80078-Naples, Italy.
authors: María
authors: M
authors: Moros
authors: Instituto de Ciencia de Materiales de Aragón (ICMA-CSIC), Universidad de Zaragoza, 50009-Zaragoza, Spain.
authors: Scott G
authors: SG
authors: Mitchell
authors: Institute of Nano Biomedicine and Engineering, Key Laboratory for Thin Film & Microfabrication Technology of the Ministry of Education, Shanghai Jiao Tong University, 200240-Shanghai, PR China.|Instituto de Ciencia de Materiales de Aragón (ICMA-CSIC), Universidad de Zaragoza, 50009-Zaragoza, Spain.
authors: Jesús M
authors: JM
authors: de la Fuente
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000008:administration & dosage / Q000737:chemistry*; D016923:Cell Death / Q000187:drug effects*; D002522:Chlorocebus aethiops; D006046:Gold / Q000737:chemistry; D006361:Heating; D006979:Hyperthermia, Induced; D053768:Metal Nanoparticles / Q000008:administration & dosage / Q000737:chemistry* / Q000648:ultrastructure; D046529:Microscopy, Electron, Transmission; D043942:Nanotubes / Q000737:chemistry* / Q000648:ultrastructure; D020349:Surface Plasmon Resonance; D014709:Vero Cells
chemical_list: D001672:Biocompatible Materials; D006046:Gold
keywords: cellular internalization; hyperthermia; near-IR; photothermal cell ablation; plasmonic gold nanoparticles