title: (C6F5)3B Catalyzed Chemoselective and ortho-Selective Substitution of Phenols with α-Aryl α-Diazoesters.
abstract: The development of an efficient method for the site-selective substitution of unprotected phenols has long been considered as an attractive but challenging task. Herein, we describe a highly chemo- and ortho-selective substitution reaction of phenols with α-aryl α-diazoacetates with commercially available (C6F5)3B as the catalyst. This reaction proceeds under simple and mild conditions with high efficiency, it features a wide substrate scope and can be easily scaled up.
authors: Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemistry, East China Normal University, 3663 North Zhongshan Road, Shanghai, 200062, China.
authors: Zhunzhun
authors: Z
authors: Yu
authors: Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemistry, East China Normal University, 3663 North Zhongshan Road, Shanghai, 200062, China.
authors: Yongfeng
authors: Y
authors: Li
authors: Department of Physics, East China Normal University, 3663 North Zhongshan Road, Shanghai, 200062, China.
authors: Jiameng
authors: J
authors: Shi
authors: Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemistry, East China Normal University, 3663 North Zhongshan Road, Shanghai, 200062, China.
authors: Ben
authors: B
authors: Ma
authors: Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemistry, East China Normal University, 3663 North Zhongshan Road, Shanghai, 200062, China.
authors: Lu
authors: L
authors: Liu
authors: Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemistry, East China Normal University, 3663 North Zhongshan Road, Shanghai, 200062, China.
authors: Junliang
authors: J
authors: Zhang
keywords: C−H functionalization; boron catalysis; chemoselectivity; diazo compounds; phenols