title: Study on Antioxidant Enzymatic Activities ofTrichosporon asahii.
abstract: Superoxide dismutase (SOD) and catalase are considered the most important antioxidant enzymes which protect fungus from the oxidant damage of reactive oxygen species. In this study, we collected 44 strains ofTrichosporon asahii(T. asahii) from different sources and investigated their SOD and catalase activities. The results showed that the SOD and catalase activities of Clinical group were significantly higher than those of Environment group (p< 0.01). The SOD and catalase activities ofT. asahiiin Internal passage group went up gradually after passage in mice, and were significantly higher in 5th generation of Internal passage group (p< 0.05). The SOD and catalase activities of Fluconazole-resistant group strains also increased after resistant induction, and the SOD and catalase activities were significantly higher in the 10th generation of Fluconazole-resistant group (p< 0.05). This implied thatT. asahiihas stronger antioxidant ability. The strains ofT. asahiifrom different sources have different antioxidant abilities, which mainly manifest in the difference of antioxidant enzymatic activities. Clinical group strains have the strongest antioxidant capacity; Internal passage group strains and Fluconazole resistant group strains better; Environmental group strains the lowest. These results also suggested that the antioxidant defensive response ofT. asahiimight be relevant to its infection mechanism and drug resistance mechanism.
authors: General Hospital of Beijing Military Command PLA, No. 5, Nanmen Cang, Dongcheng District, Beijing, 100007 China.
authors: Yangmei
authors: Y
authors: Zhang
authors: General Hospital of Beijing Military Command PLA, No. 5, Nanmen Cang, Dongcheng District, Beijing, 100007 China.
authors: Haitao
authors: H
authors: Li
authors: General Hospital of Beijing Military Command PLA, No. 5, Nanmen Cang, Dongcheng District, Beijing, 100007 China.
authors: Rongya
authors: R
authors: Yang
authors: General Hospital of Beijing Military Command PLA, No. 5, Nanmen Cang, Dongcheng District, Beijing, 100007 China.
authors: Congmin
authors: C
authors: Wang
keywords: Catalase; Reactive oxygen species; Superoxide dismutase; Trichosporon asahii