title: Primary Choriocarcinoma of the Bladder: A Case Report and Review of Literature.
abstract: Primary choriocarcinoma of the urinary bladder is a rare entity, and should be distinguished from urothelial carcinoma with trophoblastic differentiation. The leading treatment modalities include surgical extirpation, chemotherapy, and radiation; however, survival remains poor. Herein we describe a rare case of choriocarcinoma of the bladder in a man who presented for evaluation with hematuria and subsequently underwent radical cystectomy with urinary diversion. Diagnosis of extragonadal germ cell tumor was confirmed using fluorescence in situ hybridization identification of isochromosome 12p.
authors: Department of Urology, Indiana University School of Medicine, Indianapolis, IN.
authors: M Francesca
authors: MF
authors: Monn
authors: Department of Urology, Indiana University School of Medicine, Indianapolis, IN.
authors: Kaitlin R
authors: KR
authors: Jaqua
authors: Department of Urology, Indiana University School of Medicine, Indianapolis, IN.
authors: Richard
authors: R
authors: Bihrle
authors: Department of Urology, Indiana University School of Medicine, Indianapolis, IN; Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN. Electronic address: liang_cheng@yahoo.com.
authors: Liang
authors: L
authors: Cheng
mesh_terms: D000368:Aged; D031954:Choriocarcinoma, Non-gestational / Q000175:diagnosis* / Q000235:genetics / Q000601:surgery; D002881:Chromosomes, Human, Pair 12 / Q000235:genetics*; D015653:Cystectomy; D006801:Humans; D018404:Isochromosomes / Q000235:genetics; D008297:Male; D009373:Neoplasms, Germ Cell and Embryonal / Q000175:diagnosis* / Q000235:genetics / Q000601:surgery; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000601:surgery; D014547:Urinary Diversion
keywords: Bladder choriocarcinoma; Cytogenetics/fluorescence in situ hybridization; Extragonadal germ cell tumor; Isochromosome 12p (i12p); Urothelial carcinoma