title: Gelatin Binding Proteins in Reproductive Physiology.
abstract: In order to advance the assisted reproductive technologies used in animals and human beings, it is important to accumulate basic informations about underlying molecular mechanisms that shape the biological processes of reproduction. From within seminal plasma, proteins perform a wide variety of distinct functions that regulate major reproductive events such as fertilization. The ability of such proteins to bind and interact with different antagonistic ions and biomolecules such as polysaccharides, lipids, and other proteins present in the male and female reproductive tract define these capabilities. Over the last two decades, extensive work has been undertaken in an attempt to define the role of seminal plasma proteins, of which, Gelatin binding proteins (GBPs) represent a large family. GBPs comprise of known group of Bovine seminal plasma (BSP) protein family, matrix metallo proteinases (MMP 2 and MMP 9) and fibronectin, which have been widely studied. The presence of a type II repeat is a characteristic feature of GBPs, which is similar in structure to the fibronectin type II domain (fn2), which has ability to bind multiple ligands including gelatin, glycosaminoglycans, choline phospholipids, and lipoproteins. Two fn2 domains are present within the BSP protein family, while, three fn2 domains are found in gelatinases (MMP-2 and MMP9), and ELSPBP1 (Epididymosomes Transfer Epididymal Sperm Binding Protein 1) contains four long fn2 domains. For the most part BSP proteins are exclusively expressed in seminal vesicles although mBSPH1, mBSPH2 and hBSPH1 are all expressed in the epididymis. The expression of gelatinases has been demonstrated in several organs and tissues such as the prostate, testis, epididymis, ovary, human placenta, cervix and endometrial wall. This review intends to bring current updates on the role of GBPs in reproductive physiology to light, which may act as basis for future studies on GBPs.
authors: In Vitro Fertilization (IVF) Laboratory, Management of Scientific Center and Presidential Camels, Department of President's Affairs (DOPA), Hili, Al Ain, Post Office (PO) Box-17292, Abu Dhabi, United Arab Emirates.
authors: Sanjay
authors: S
authors: Kumar
authors: In Vitro Fertilization (IVF) Laboratory, Management of Scientific Center and Presidential Camels, Department of President's Affairs (DOPA), Hili, Al Ain, Post Office (PO) Box-17292, Abu Dhabi, United Arab Emirates.
authors: Alex
authors: A
authors: Tinson
authors: In Vitro Fertilization (IVF) Laboratory, Management of Scientific Center and Presidential Camels, Department of President's Affairs (DOPA), Hili, Al Ain, Post Office (PO) Box-17292, Abu Dhabi, United Arab Emirates.
authors: Brendan Patrick
authors: BP
authors: Mulligan
authors: Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University, Post Office (PO) Box-17666, Al Ain, Abu Dhabi, United Arab Emirates.
authors: Shreesh
authors: S
authors: Ojha
keywords: Bovine seminal plasma (BSP) proteins; Fibronectin type II (fn2) domain; Gelatin binding proteins (GBPs); MMP-2; MMP-9; Reproductive physiology