title: Diagnostic performance of noninvasive fractional flow reserve derived from coronary computed tomography angiography in ischemia-causing coronary stenosis: a meta-analysis.
abstract: OBJECTIVE
  Fractional flow reserve based on coronary computed tomographic angiography (CCTA; FFRCT) can evaluate functional severity in coronary artery disease (CAD). This study investigated the diagnostic value of FFRCTfor determining CAD severity.
  
  
  METHODS
  Medline, Cochrane, EMBASE, and Google Scholar databases were searched until June 16, 2016 using the following search terms: fractional flow reserve, coronary computed tomography angiography, myocardial ischemia. Randomized controlled trials, two-arm prospective studies, and retrospective studies were included in the analysis.
  
  
  RESULTS
  Twenty-one studies were included with a total of 2216 subjects and 2798 vessels. FFRCT, sensitivity per-vessel and per-patient were ≥82% and specificity was ≥73% for diagnosis of ischemia. FFRCThad better diagnostic accuracy and discrimination than CCTA.
  
  
  CONCLUSIONS
  This study indicates that FFRCTmay be a good tool for screening and diagnosing of myocardial ischemia in patients with CAD.
authors: The Second Medical Imaging Department of the First People's Hospital of Fuzhou, Jiangxi Province, No. 421 Gan Dong Avenue, Lin Chuan District, Fuzhou, Jiangxi, 344100, China. 5413dam@163.com.
authors: Aimin
authors: A
authors: Ding
authors: The Second Medical Imaging Department of the First People's Hospital of Fuzhou, Jiangxi Province, No. 421 Gan Dong Avenue, Lin Chuan District, Fuzhou, Jiangxi, 344100, China.
authors: Guoqing
authors: G
authors: Qiu
authors: The Second Medical Imaging Department of the First People's Hospital of Fuzhou, Jiangxi Province, No. 421 Gan Dong Avenue, Lin Chuan District, Fuzhou, Jiangxi, 344100, China.
authors: Wensheng
authors: W
authors: Lin
authors: The Second Medical Imaging Department of the First People's Hospital of Fuzhou, Jiangxi Province, No. 421 Gan Dong Avenue, Lin Chuan District, Fuzhou, Jiangxi, 344100, China.
authors: Ling
authors: L
authors: Hu
authors: The Second Medical Imaging Department of the First People's Hospital of Fuzhou, Jiangxi Province, No. 421 Gan Dong Avenue, Lin Chuan District, Fuzhou, Jiangxi, 344100, China.
authors: Guangliang
authors: G
authors: Lu
authors: The Second Medical Imaging Department of the First People's Hospital of Fuzhou, Jiangxi Province, No. 421 Gan Dong Avenue, Lin Chuan District, Fuzhou, Jiangxi, 344100, China.
authors: Xiang
authors: X
authors: Long
authors: The Second Medical Imaging Department of the First People's Hospital of Fuzhou, Jiangxi Province, No. 421 Gan Dong Avenue, Lin Chuan District, Fuzhou, Jiangxi, 344100, China.
authors: Xin
authors: X
authors: Hong
authors: The Second Medical Imaging Department of the First People's Hospital of Fuzhou, Jiangxi Province, No. 421 Gan Dong Avenue, Lin Chuan District, Fuzhou, Jiangxi, 344100, China.
authors: Yaohua
authors: Y
authors: Chen
authors: The Second Medical Imaging Department of the First People's Hospital of Fuzhou, Jiangxi Province, No. 421 Gan Dong Avenue, Lin Chuan District, Fuzhou, Jiangxi, 344100, China.
authors: Xiaoping
authors: X
authors: Luo
authors: The Second Medical Imaging Department of the First People's Hospital of Fuzhou, Jiangxi Province, No. 421 Gan Dong Avenue, Lin Chuan District, Fuzhou, Jiangxi, 344100, China.
authors: Qinqin
authors: Q
authors: Tang
authors: The Second Medical Imaging Department of the First People's Hospital of Fuzhou, Jiangxi Province, No. 421 Gan Dong Avenue, Lin Chuan District, Fuzhou, Jiangxi, 344100, China.
authors: Dongqin
authors: D
authors: Deng
mesh_terms: D019540:Area Under Curve; D000072226:Computed Tomography Angiography / Q000379:methods*; D017023:Coronary Angiography / Q000379:methods*; D023921:Coronary Stenosis / Q000150:complications* / Q000000981:diagnostic imaging* / Q000503:physiopathology; D053805:Fractional Flow Reserve, Myocardial / Q000502:physiology*; D006801:Humans; D017202:Myocardial Ischemia / Q000000981:diagnostic imaging* / Q000209:etiology* / Q000503:physiopathology; D012372:ROC Curve; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index
keywords: Coronary artery disease; Coronary computed tomography angiography; Fractional flow reserve; Myocardial ischemia; Stenosis