title: Prognostic Significance of MiRNA in Patients with Diffuse Large B-Cell Lymphoma: a Meta-Analysis.
abstract: BACKGROUND
  This pooled analysis study aimed to reveal the prognostic relevance of microRNAs (miRNAs) in patients with diffuse large B-cell lymphoma (DLBCL).
  
  
  METHODS
  We examined the impact of miRNAs on clinical outcome. Eligible studies were identified and quality assessed using multiple search strategies. Data were extracted from included studies which correlated survival with expression of miRNAs (serum or tissue).
  
  
  RESULTS
  We pooled proper studies, and combined the hazard ratios with 95% confidence intervals to estimate strength of the correlations. There were 18 studies including 1950 patients with DLBCL eligible for pooled analysis. We found significant combined HRs for poor overall survival for high expression of miR-21 and low expression of miR-224 in tumor tissue, but for favorable relapse free survival for high expression of miR-21 in serum. Progression free survival was shortened in patients with low expression of miR-199a/b, miR-146b-5p, miR-224 and high expression of miR-222.
  
  
  CONCLUSIONS
  MiRNAs may act as independent prognostic factors in patients with DLBCL, and useful in risk stratification.
authors: Department of Hematology, The Third Affiliated Hospital, Soochow University, Changzhou, China.
authors: Zhuojun
authors: Z
authors: Zheng
authors: Xiaodong
authors: X
authors: Li
authors: Yuandong
authors: Y
authors: Zhu
authors: Weiying
authors: W
authors: Gu
authors: Xiaobao
authors: X
authors: Xie
authors: Jingting
authors: J
authors: Jiang
mesh_terms: D018572:Disease-Free Survival; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis* / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D035683:MicroRNAs / Q000235:genetics*; D011379:Prognosis; D016016:Proportional Hazards Models; D015398:Signal Transduction
chemical_list: D035683:MicroRNAs; C542542:MIRN146 microRNA, human; C549214:MIRN19A microRNA, human; C524940:MIRN21 microRNA, human; C525710:MIR222, human; C546140:MIRN224 microRNA, human; C531408:mirn199 microRNA, human