title: Role of α7-Nicotinic Acetylcholine Receptors of B Cells in the Immunotoxic Effect of Organophosphorus Compounds.
abstract: Experiments on white non-inbred rats demonstrated that treatment with organophosphorus compound dimethyl dichlorovinyl phosphate (DDVP) decreased T cell-independent antibody production by B cells and blood levels of IL-10 and IL-12; a similar effect was produced by GTS-21, a selective agonist of α7-nicotinic acetylcholine receptor. N-nicotinic receptor antagonist chlorisondamine in combination with DDVP partially prevented suppression of antibody production in comparison with the effect observed during intoxication with DDVP.
authors: Saratov Branch of the Samara Medical Institute REAVIZ, Saratov, Russia. pfzabrodsky@gmail.com.
authors: P F
authors: PF
authors: Zabrodskii
authors: Saratov Branch of the Samara Medical Institute REAVIZ, Saratov, Russia.
authors: V V
authors: VV
authors: Maslyakov
authors: Saratov Branch of the Samara Medical Institute REAVIZ, Saratov, Russia.
authors: M S
authors: MS
authors: Gromov
mesh_terms: D000818:Animals; D021461:Animals, Outbred Strains; D001402:B-Lymphocytes / Q000166:cytology / Q000187:drug effects* / Q000276:immunology; D001597:Benzylidene Compounds / Q000494:pharmacology; D002714:Chlorisondamine / Q000494:pharmacology*; D002800:Cholinesterase Inhibitors / Q000276:immunology / Q000633:toxicity*; D004006:Dichlorvos / Q000037:antagonists & inhibitors / Q000276:immunology / Q000633:toxicity*; D005260:Female; D007075:Immunoglobulin M / Q000096:biosynthesis; D007273:Injections, Intramuscular; D016753:Interleukin-10 / Q000096:biosynthesis / Q000378:metabolism; D018664:Interleukin-12 / Q000096:biosynthesis / Q000378:metabolism; D008297:Male; D018722:Nicotinic Agonists / Q000494:pharmacology; D018733:Nicotinic Antagonists / Q000494:pharmacology*; D011725:Pyridines / Q000494:pharmacology; D051381:Rats; D013154:Spleen / Q000166:cytology / Q000187:drug effects / Q000276:immunology; D064569:alpha7 Nicotinic Acetylcholine Receptor / Q000276:immunology* / Q000378:metabolism
chemical_list: D001597:Benzylidene Compounds; D002800:Cholinesterase Inhibitors; D007075:Immunoglobulin M; D018722:Nicotinic Agonists; D018733:Nicotinic Antagonists; D011725:Pyridines; D064569:alpha7 Nicotinic Acetylcholine Receptor; D016753:Interleukin-10; D018664:Interleukin-12; D004006:Dichlorvos; C088936:3-(2,4-dimethoxybenzylidene)anabaseine; D002714:Chlorisondamine
keywords: B cells; IL-10; IL-12; organophosphorus compounds; α7-nicotinic acetylcholine receptors