title: Skin appendage-derived stem cells: cell biology and potential for wound repair.
abstract: Stem cells residing in the epidermis and skin appendages are imperative for skin homeostasis and regeneration. These stem cells also participate in the repair of the epidermis after injuries, inducing restoration of tissue integrity and function of damaged tissue. Unlike epidermis-derived stem cells, comprehensive knowledge about skin appendage-derived stem cells remains limited. In this review, we summarize the current knowledge of skin appendage-derived stem cells, including their fundamental characteristics, their preferentially expressed biomarkers, and their potential contribution involved in wound repair. Finally, we will also discuss current strategies, future applications, and limitations of these stem cells, attempting to provide some perspectives on optimizing the available therapy in cutaneous repair and regeneration.
authors: Key Laboratory of Tissue Repair and Regeneration of PLA, and Beijing Key Research Laboratory of Skin Injury, Repair and Regeneration, First Hospital Affiliated to General Hospital of PLA, 51 Fu Cheng Road, Beijing, 100048 People's Republic of China.
authors: Jiangfan
authors: J
authors: Xie
authors: Key Laboratory of Tissue Repair and Regeneration of PLA, and Beijing Key Research Laboratory of Skin Injury, Repair and Regeneration, First Hospital Affiliated to General Hospital of PLA, 51 Fu Cheng Road, Beijing, 100048 People's Republic of China ; School of Medicine, Nankai University, Tianjin, 300052 People's Republic of China.
authors: Bin
authors: B
authors: Yao
authors: Graduate School of the Second Teaching Hospital of Zhengzhou University, Zhengzhou, 450000 People's Republic of China.
authors: Yutong
authors: Y
authors: Han
authors: Key Laboratory of Tissue Repair and Regeneration of PLA, and Beijing Key Research Laboratory of Skin Injury, Repair and Regeneration, First Hospital Affiliated to General Hospital of PLA, 51 Fu Cheng Road, Beijing, 100048 People's Republic of China ; Wound Healing and Cell Biology Laboratory, Institute of Basic Medical Sciences, General Hospital of PLA, Beijing, 100853 People's Republic of China.
authors: Sha
authors: S
authors: Huang
authors: Key Laboratory of Tissue Repair and Regeneration of PLA, and Beijing Key Research Laboratory of Skin Injury, Repair and Regeneration, First Hospital Affiliated to General Hospital of PLA, 51 Fu Cheng Road, Beijing, 100048 People's Republic of China ; Wound Healing and Cell Biology Laboratory, Institute of Basic Medical Sciences, General Hospital of PLA, Beijing, 100853 People's Republic of China.
authors: Xiaobing
authors: X
authors: Fu
keywords: Cell biology; Skin appendages; Stem cells; Wound healing