title: Long-term clinical response to treatment and maintenance of localized aggressive periodontitis: a cohort study.
abstract: To evaluate long-term clinical response to periodontal therapy and maintenance in localized aggressive periodontitis (LAP).
  
  
  
  One hundred forty-one African Americans diagnosed with LAP, aged 5-25 years, were enrolled. Patients underwent periodontal mechanical debridement plus 1 week of amoxicillin/metronidazole. Mechanical therapy was repeated as needed and clinical parameters were recorded at baseline, 3, 6, 12, 18 and 24 months, and two additional annual follow-up visits after treatment. Radiographs from primary dentition of patients with LAP in permanent dentition, and additional healthy siblings (HS) were analysed retrospectively.
  
  
  
  Periodontal therapy significantly improved probing depth and clinical attachment level up to 4 years (mean reductions: 2.18 ± 1.03 and 2.80 ± 1.43 mm, respectively). Percentage of affected sites was reduced at all time points and maintained up to 4 years. Non-compliance with antibiotics/appointments negatively affected the treatment response. Ninety per cent of LAP patients in permanent dentition and 32% of HS presented radiographic bone loss in primary dentition.
  
  
  
  Mechanical debridement with 1 week of systemic antibiotics along with proper periodontal maintenance was effective in the treatment and successful maintenance of LAP for up to 4 years. LAP in permanent dentition may be preceded in the primary dentition. Clinicaltrials.gov #NCT01330719.
authors: Department of Periodontology, College of Dentistry, University of Florida, Gainesville, FL, USA.
authors: Karina A F S
authors: KA
authors: Miller
authors: Department of Periodontology, College of Dentistry, University of Florida, Gainesville, FL, USA.|Department of Dentistry II, School of Dentistry, Federal University of Maranhão, São Luís, MA, Brazil.
authors: Luciana S
authors: LS
authors: Branco-de-Almeida
authors: Department of Periodontology, College of Dentistry, University of Florida, Gainesville, FL, USA.
authors: Sandra
authors: S
authors: Wolf
authors: Department of Periodontology, College of Dentistry, University of Florida, Gainesville, FL, USA.
authors: Nicole
authors: N
authors: Hovencamp
authors: Department of Periodontology, College of Dentistry, University of Florida, Gainesville, FL, USA.
authors: Tina
authors: T
authors: Treloar
authors: Department of Periodontology, College of Dentistry, University of Florida, Gainesville, FL, USA.|Division of Restorative Dentistry & Periodontology, Dublin Dental University Hospital, Trinity College Dublin, Dublin, Ireland.
authors: Peter
authors: P
authors: Harrison
authors: Department of Periodontology, College of Dentistry, University of Florida, Gainesville, FL, USA.
authors: Ikramuddin
authors: I
authors: Aukhil
authors: Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, College of Pharmacy, University of Florida, Gainesville, FL, USA.
authors: Yan
authors: Y
authors: Gong
authors: Department of Periodontology, College of Dentistry, University of Florida, Gainesville, FL, USA.
authors: Luciana M
authors: LM
authors: Shaddox
mesh_terms: D000293:Adolescent; D000328:Adult; D010520:Aggressive Periodontitis / Q000000981:diagnostic imaging / Q000628:therapy*; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D011861:Radiography, Dental; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult
keywords: aggressive periodontitis; antibiotics; dental scaling; long-term effects; maintenance; patient compliance; root planing; therapy