title: Evidence of hepatitis E virus transmission by renal graft.
abstract: Hepatitis E virus (HEV) can cause chronic infection among immunocompromised patients, especially solid organ transplant recipients, and can evolve to cirrhosis. Several modes of transmission are known. Here we describe the first two cases, to our knowledge, of HEV infection transmitted by a kidney graft from the same infected donor that led to chronic hepatitis. Consequently, systematic screening of donors by HEV serology and HEV RNA detection by polymerase chain reaction, particularly in endemic regions, should be considered.
authors: Department of Renal ICU and Kidney Transplantation, Tenon Hospital, Paris, France.
authors: Annabelle
authors: A
authors: Pourbaix
authors: Department of Renal ICU and Kidney Transplantation, Tenon Hospital, Paris, France.
authors: Nacera
authors: N
authors: Ouali
authors: Department of Virology, Tenon Hospital, Paris, France.
authors: Patrick
authors: P
authors: Soussan
authors: Department of Virology, Paul Brousse Hospital, Villejuif, France.
authors: Anne Marie
authors: AM
authors: Roque Afonso
authors: Department of Kidney Transplantation, Saint Louis Hospital, Paris, France.
authors: Marie-Noelle
authors: MN
authors: Péraldi
authors: Department of Renal ICU and Kidney Transplantation, Tenon Hospital, Paris, France.
authors: Eric
authors: E
authors: Rondeau
authors: Department of Renal ICU and Kidney Transplantation, Tenon Hospital, Paris, France.
authors: Julie
authors: J
authors: Peltier
mesh_terms: D000368:Aged; D064591:Allografts / Q000821:virology*; D016751:Hepatitis E / Q000097:blood / Q000175:diagnosis / Q000635:transmission* / Q000821:virology; D016752:Hepatitis E virus / Q000302:isolation & purification*; D006521:Hepatitis, Chronic / Q000097:blood / Q000175:diagnosis / Q000821:virology; D006801:Humans; D016867:Immunocompromised Host; D007165:Immunosuppression Therapy / Q000009:adverse effects*; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D009400:Nephrosclerosis / Q000601:surgery; D012367:RNA, Viral / Q000302:isolation & purification*; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D012367:RNA, Viral
keywords: chronic hepatitis E; renal graft; transmission; transplantation