title: Assessment of Diastolic Function in Hypertrophic Cardiomyopathy by Computed Tomography-Derived Analysis of Left Ventricular Filling.
abstract: OBJECTIVE
  Hypertrophic cardiomyopathy (HCM) is characterized by diastolic dysfunction, which is difficult to assess by noninvasive methods. We hypothesized that measurement of simultaneous left ventricular (LV) and left atrial (LA) volume changes by cardiac computed tomography would be useful in the assessment of diastolic function in HCM.
  
  
  METHODS
  We studied 21 patients with HCM and 21 age-matched controls. The LA and LV volumes were calculated and early and late diastolic volume changes derived.
  
  
  RESULTS
  The HCM patients had significantly larger LA volumes and reduced LA total emptying fraction (30 ± 7% vs 42 ± 6%; P < 0.0001). Conduit volume was increased (30 ± 6 vs 22 ± 4 mL/m; P < 0.0001) and contributed a significantly higher proportion of total LV diastolic filling, suggesting that passive filling of the LV compensates for LA dysfunction, but at the expense of increased pulmonary filling pressure.
  
  
  CONCLUSIONS
  This study suggests that simultaneous depiction of computed tomography-derived LV and LA volume changes can characterize diastolic dysfunction in HCM.
authors: From the *Technion-Israel Institute of Technology, Haifa, Israel; †Department of Radiology, Leonard M. Miller School of Medicine, University of Miami, Miami, FL; ‡Medical Imaging Department and §Cardiology Department, Rambam Health Care Campus, Haifa, Israel; and ∥Department of Cardiology, Leonard M. Miller School of Medicine, University of Miami, Miami, FL.
authors: Itai
authors: I
authors: Ghersin
authors: Eduard
authors: E
authors: Ghersin
authors: Sobhi
authors: S
authors: Abadi
authors: Jennifer E
authors: JE
authors: Runco Therrien
authors: Tanyanan
authors: T
authors: Tanawuttiwat
authors: Doron
authors: D
authors: Aronson
authors: Jonathan
authors: J
authors: Lessick
mesh_terms: D000328:Adult; D000368:Aged; D002312:Cardiomyopathy, Hypertrophic / Q000150:complications / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D003971:Diastole / Q000502:physiology*; D005260:Female; D006352:Heart Ventricles / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013318:Stroke Volume / Q000502:physiology; D014057:Tomography, X-Ray Computed; D018487:Ventricular Dysfunction, Left / Q000150:complications / Q000000981:diagnostic imaging* / Q000503:physiopathology*