title: The relationship between cognitive function and quality of life in euthymic Chinese patients with bipolar disorder.
abstract: This study aimed to identify the relationship between cognitive function and quality of life (QOL) in Chinese patients with bipolar disorder (BD) in the remission stage, by adopting disease-specific instruments. The remission stage was assessed using the Hamilton Depression Rating Scale (HAMD) and the Bech-Rafaelsen Mania Rating Scale (BRMS). One hundred euthymic bipolar patients and 115 healthy controls completed the "cognitive complaints in bipolar disorder rating assessment"(COBRA), Montreal Cognitive Assessment scale (MoCA), and "Brief version of Quality of Life in Bipolar Disorder" (Bref QOL.BD), which were used to assess the subjective cognitive function, objective cognitive function, and QOL, respectively. Compared to the healthy controls, the patient group had significantly lower total scores on both MoCA and Brief QOL.BD, and higher total score of COBRA. After controlling the influence of mood symptoms (HAMD and BRMS), both objective (MoCA) and subjective (COBRA) cognitive function could predict QOL significantly when entered either separately or simultaneously into hierarchical multiple regression models. When entered simultaneously, cognitive function explained 21% of the variance in QOL. The findings indicated that both objective and subjective cognitive function could influence QOL in euthymic bipolar patients, so continuous cognitive-improving interventions could help euthymic bipolar patients improve their QOL.
authors: School of Nursing, Southern Medical University, 1023 Sha Tai South road, Bai Yun district, Guang Zhou, Guangdong province 510515, China. Electronic address: 757462438@qq.com.
authors: Lin
authors: L
authors: Xiao
authors: School of Nursing, Southern Medical University, 1023 Sha Tai South road, Bai Yun district, Guang Zhou, Guangdong province 510515, China.
authors: Yulin
authors: Y
authors: Gao
authors: School of Nursing, Southern Medical University, 1023 Sha Tai South road, Bai Yun district, Guang Zhou, Guangdong province 510515, China. Electronic address: 360509087@qq.com.
authors: Lili
authors: L
authors: Zhang
authors: School of Nursing, Southern Medical University, 1023 Sha Tai South road, Bai Yun district, Guang Zhou, Guangdong province 510515, China.
authors: Peiyun
authors: P
authors: Chen
authors: School of Nursing, Southern Medical University, 1023 Sha Tai South road, Bai Yun district, Guang Zhou, Guangdong province 510515, China.
authors: Xiaojia
authors: X
authors: Sun
mesh_terms: D000328:Adult; D001714:Bipolar Disorder / Q000503:physiopathology*; D002681:China; D060825:Cognitive Dysfunction / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D011788:Quality of Life; D055815:Young Adult
keywords: Bipolar disorder; Cognition; Quality of life