title: Diagnostic and prognostic value of serum MACC1 in breast cancer patients.
abstract: Metastasis-associated in colon cancer-1 (MACC1) promotes colorectal cancer progression and predicts prognosis. The aim of our study was to determine the diagnostic and prognostic value of preoperative serum MACC1 levels in breast cancer patients. Serum MACC1 levels were measured in 378 breast cancer patients, 120 patients with benign breast disease, and 40 healthy volunteers using an ELISA. Serum MACC1 levels were higher in breast cancer patients than patients with benign disease or healthy volunteers. Increased serum MACC1 was associated with breast cancer TNM stage (P < 0.001), tumor size (P < 0.001), lymph node metastasis (P < 0.001), and Ki-67 status (P = 0.014). Serum MACC1 measurement successfully discriminated breast cancer patients from normal and healthy controls (AUC = 0.785, 95% CI: 0.746-0.825) with an optimal cut-off value of 38.35 pg/ml (sensitivity = 0.725, specificity = 0.696). Moreover, serum MACC1 exhibited significant prognostic value in breast cancer (AUC = 0.757, 95% CI: 0.700-0.814), and high MACC1 was associated with poor disease-free survival (HR 5.63, 95% CI: 3.51-9.04; P < 0.001). Our findings demonstrated that circulating MACC1 could serve as a reliable diagnostic and prognostic biomarker for breast cancer.
authors: Department of Breast Surgery, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, China.
authors: Weige
authors: W
authors: Tan
authors: Department of Breast Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, China.|Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, 510060, China.
authors: Xinhua
authors: X
authors: Xie
authors: Department of Laboratory Medicine, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510080, China.
authors: Laisheng
authors: L
authors: Li
authors: Department of Breast Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, China.|Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, 510060, China.
authors: Hailin
authors: H
authors: Tang
authors: Department of Breast Surgery, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, China.
authors: Xigang
authors: X
authors: Ye
authors: Department of Breast Surgery, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, China.
authors: Lun
authors: L
authors: Chen
authors: Department of Breast Surgery, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, China.
authors: Wei
authors: W
authors: Tang
authors: Department of Breast Surgery, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, China.
authors: Jin
authors: J
authors: Gao
authors: Department of Breast Surgery, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, China.
authors: Lingxiao
authors: L
authors: Pan
authors: Department of Breast Surgery, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, China.
authors: Xiaoshen
authors: X
authors: Zhang
authors: Department of Breast Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, China.|Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, 510060, China.
authors: Feng
authors: F
authors: Ye
authors: Department of Breast Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, China.|Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, 510060, China.
authors: Xing
authors: X
authors: Li
authors: Department of Breast Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, China.|Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, 510060, China.
authors: Lu
authors: L
authors: Yang
authors: Department of Breast Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, China.|Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, 510060, China.
authors: Xiaoming
authors: X
authors: Xie
authors: Department of Breast Surgery, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, China.
authors: Wenbo
authors: W
authors: Zheng
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000097:blood*; D001943:Breast Neoplasms / Q000097:blood* / Q000175:diagnosis* / Q000628:therapy; D018572:Disease-Free Survival; D006801:Humans; D008207:Lymphatic Metastasis; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D017063:Outcome Assessment, Health Care / Q000379:methods / Q000706:statistics & numerical data; D011237:Predictive Value of Tests; D011379:Prognosis; D016016:Proportional Hazards Models; D015534:Trans-Activators; D014157:Transcription Factors / Q000097:blood*
chemical_list: D014408:Biomarkers, Tumor; C544162:MACC1 protein, human; D015534:Trans-Activators; D014157:Transcription Factors
keywords: MACC1; biomarker; breast cancer; diagnosis; serum