title: Fibro markers for prediction of hepatocellular carcinoma in Egyptian patients with chronic liver disease.
abstract: It is well known that hepatocellular carcinoma (HCC) develops as a consequence of hepatic fibrosis progression. In this study, we aimed to evaluate the inflammatory and fibrosis markers as predictors for HCC development among patients with hepatitis C virus (HCV) related chronic liver disease to help in early diagnosis and management of HCC. A total of 280 patients with chronic liver disease were included in this retrospective study, out of them 140 had liver cirrhosis with HCC and 140 had cirrhosis without HCC. Eight readily available blood indices King score, Fibro Q, AST-ALT ratio (AAR), APRI, LOK index, Goteborg University Cirrhosis Index (GUCI), fibro alpha, and Biotechnology Research Center (BRC) were constructed to compare the accuracies of these non invasive scores in predicting HCC development. All fibrosis scores except APRI were significantly higher in HCC. We found that Fibro alpha and BRC had superior diagnostic performance in prediction of HCC based on area under curve of 0.91 and 0.93, respectively compared to other scores with area under curve ranged from poor to failure (0.59-0.66). Almost all cirrhotic cases were secondary to HCV (93.6%), while HBV was detected in 2.1% of cases only. Anti-HCV positive was reported in 100% of HCC cases (P = 0.002). Fibro alpha and BRC scores can be used for prediction of HCC. J. Med. Virol. 89:1062-1068, 2017. © 2016 Wiley Periodicals, Inc.
authors: National Hepatology and Tropical Medicine Research Institute, Cairo, Egypt.
authors: Lamiaa
authors: L
authors: Mobarak
authors: Faculty of Medicine, Department of Endemic Medicine and Hepato-gastroenterology, Cairo University, Cairo, Egypt.
authors: Dalia
authors: D
authors: Omran
authors: Faculty of Medicine, Department of Endemic Medicine and Hepato-gastroenterology, Cairo University, Cairo, Egypt.
authors: Mohammed M
authors: MM
authors: Nabeel
authors: Faculty of Medicine, Department of Endemic Medicine and Hepato-gastroenterology, Cairo University, Cairo, Egypt.
authors: Zeinab
authors: Z
authors: Zakaria
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood*; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis*; D004534:Egypt; D005260:Female; D019698:Hepatitis C, Chronic / Q000150:complications*; D006801:Humans; D008099:Liver / Q000473:pathology*; D008103:Liver Cirrhosis / Q000150:complications* / Q000175:diagnosis*; D008113:Liver Neoplasms / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012372:ROC Curve; D012189:Retrospective Studies
chemical_list: D015415:Biomarkers
keywords:  noninvasive fibrosis scores; chronic liver disease; hepatocellular carcinoma (HCC); prediction