title: A Facile Approach to Upconversion Crystalline CaF2:Yb3+,Tm3+@mSiO2Nanospheres for Tumor Therapy.
abstract: A new facile approach, namely chemical-assisted sol-gel growth (CASGG), was successfully developed to induce the formation of fine CaF2:Yb3+, Tm3+nanocrytals within the pore channels of mesoporous silica (mSiO2) nanoparticles. A series of upconversion photoluminescent crystalline CaF2:Yb3+,Tm3+@mSiO2nanospheres with controlled diameters from~65 nm to~290 nm were fabricated. All nanospheres presented sound cyto-compatibility and unique ratiometric spectral monitoring functionalities for drug release kinetics. The nanospheres with smallest dimension (UCNP-2.5,~65nm) induced the most sustained DOX release kinetics. More importantly, thein-vitrostudy demonstrated that the DOX loaded UCNP-2.5 nanopheres presented the strongest anti-cancer efficacy to MCF-7 human breast cancer cells due to its stronger penetration ability to cell nuclei due to the size effect.
authors: State Key Laboratory of Silicon Materials, School of Materials Science and Engineering, Zhejiang University, Hangzhou, Zhejiang 310027, P. R. China.
authors: Yangyang
authors: Y
authors: Li
authors: Department of Radiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310016, P. R. China.
authors: Yurong
authors: Y
authors: Zhou
authors: State Key Laboratory of Silicon Materials, School of Materials Science and Engineering, Zhejiang University, Hangzhou, Zhejiang 310027, P. R. China.
authors: Xiang
authors: X
authors: Li
authors: Department of Radiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310016, P. R. China.
authors: Jihong
authors: J
authors: Sun
authors: State Key Laboratory of Silicon Materials, School of Materials Science and Engineering, Zhejiang University, Hangzhou, Zhejiang 310027, P. R. China.
authors: Zhaohui
authors: Z
authors: Ren
authors: State Key Laboratory of Silicon Materials, School of Materials Science and Engineering, Zhejiang University, Hangzhou, Zhejiang 310027, P. R. China.
authors: Wengjian
authors: W
authors: Wen
authors: Department of Radiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310016, P. R. China.|Image-Guided Bio-Molecular Interventions Research, Department of Radiology, University of Washington School of Medicine, Seattle, Washington, 98109 USA.
authors: Xiaoming
authors: X
authors: Yang
authors: State Key Laboratory of Silicon Materials, School of Materials Science and Engineering, Zhejiang University, Hangzhou, Zhejiang 310027, P. R. China.
authors: Gaorong
authors: G
authors: Han