title: Thoracic aortic rupture in horses.
abstract: The aorta can rupture at the aortic root or aortic arch. In most breeds, the aortic root is the likely site and rupture leads to aortocardiac fistula with communication between the aorta and the right atrium, right ventricle and/or the interventricular septum. There is a high prevalence of aortic rupture in young Friesian horses and rupture occurs at the aortic arch with pseudoaneurysm and potentially aortopulmonary fistulation. Echocardiographic and post-mortem techniques must be adapted to identify aortic arch rupture that is not generally identified with standard approaches. Given the narrow genetic base of the Friesian breed and the significant differences found in extracellular matrix composition and metabolism between Friesians and Warmbloods, genetic factors are likely to contribute to the condition in the Friesian breed.
authors: Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands.
authors: M
authors: M
authors: Ploeg
authors: Department of Pathology, Bacteriology and Poultry Diseases, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
authors: V
authors: V
authors: Saey
authors: Department of Large Animal Internal Medicine, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
authors: G
authors: G
authors: van Loon
authors: Department of Comparative Physiology and Biometrics, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
authors: C
authors: C
authors: Delesalle
mesh_terms: D000818:Animals; D001019:Aortic Rupture / Q000235:genetics / Q000662:veterinary*; D020022:Genetic Predisposition to Disease; D006734:Horse Diseases / Q000235:genetics / Q000473:pathology*; D006736:Horses
keywords: Friesian; aorta; aortocardiac fistula; aortopulmonary fistula; horse; rupture