A novel resting-state functional magnetic resonance imaging signature of resilience to recurrent depression.
BACKGROUND
A high proportion of patients with remitted major depressive disorder (MDD) will experience recurring episodes, whilst some develop resilience and remain in recovery. The neural basis of resilience to recurrence is elusive. Abnormal resting-state connectivity of the subgenual cingulate cortex (sgACC) was previously found in cross-sectional studies of MDD, suggesting its potential pathophysiological importance. The current study aimed to investigate whether resting-state connectivity to a left sgACC seed region distinguishes resilient patients from those developing recurring episodes.


METHODS
A total of 47 medication-free remitted MDD patients and 38 healthy controls underwent resting-state functional magnetic resonance imaging (fMRI) at baseline. Over 14 months, 30 patients remained resilient whilst 17 experienced a recurring episode.


RESULTS
Attenuated interhemispheric left-to-right sgACC connectivity distinguished the resilient from the recurring-episode and control groups and was not correlated with residual depressive symptoms.


CONCLUSIONS
The current study revealed a neural signature of resilience to recurrence in MDD and thereby elucidates the role of compensatory adaptation in sgACC networks.
The University of Manchester & Manchester Academic Health Sciences Centre,Institute of Brain, Behaviour and Mental Health, Neuroscience & Psychiatry Unit,Manchester,UK.
C I
CI
Workman
The University of Manchester & Manchester Academic Health Sciences Centre,School of Psychological Sciences, Neuroscience and Aphasia Research Unit,Manchester,UK.
K E
KE
Lythe
The University of Manchester & Manchester Academic Health Sciences Centre,Institute of Brain, Behaviour and Mental Health, Neuroscience & Psychiatry Unit,Manchester,UK.
S
S
McKie
Cognitive and Behavioral Neuroscience Unit,D'Or Institute for Research and Education (IDOR),Rio de Janeiro,RJ,Brazil.
J
J
Moll
The University of Manchester & Manchester Academic Health Sciences Centre,School of Psychological Sciences, Neuroscience and Aphasia Research Unit,Manchester,UK.
J A
JA
Gethin
The University of Manchester & Manchester Academic Health Sciences Centre,Institute of Brain, Behaviour and Mental Health, Neuroscience & Psychiatry Unit,Manchester,UK.
J F W
JF
Deakin
The University of Manchester & Manchester Academic Health Sciences Centre,Institute of Brain, Behaviour and Mental Health, Neuroscience & Psychiatry Unit,Manchester,UK.
R
R
Elliott
The University of Manchester & Manchester Academic Health Sciences Centre,School of Psychological Sciences, Neuroscience and Aphasia Research Unit,Manchester,UK.
R
R
Zahn
D000328:Adult; D063132:Connectome / Q000379:methods*; D003865:Major Depressive Disorder / Q000000981:diagnostic imaging / Q000503:physiopathology*; D004198:Disease Susceptibility; D005260:Female; D005500:Follow-Up Studies; D006179:Gyrus Cinguli / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012074:Remission Induction; D055815:Young Adult
Biomarkers; depression; frontal lobes; longitudinal studies