Searching for anti-glioma activity. Ribonucleoside analogues with modifications in nucleobase and sugar moieties.
Several ribonucleoside analogues with modifications in the nucleobase and sugar moiety have been screened for anti-glioma activity in the T98G glioma cell line using cervical (HeLa) cell line as reference human malignant cells, and lung fibroblast (MCR-5) cell line as non-cancerous reference cells. Among the investigated compounds, ribonucleosides containing 6-chloropurine (3), 7-guanine (5) and a pyrrolopyrimidine (18) as nucleobases, show promising anti-glioma activity with good selectivity indices, and can be considered as lead structures for further anti-cancer studies.
Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznań, Poland.
Grzegorz
G
Framski
Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznań, Poland.
Dariusz
D
Wawrzyniak
Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznań, Poland.
Zofia
Z
Jahnz-Wechmann
Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznań, Poland.
Agnieszka
A
Szymanska-Michalak
Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznań, Poland.
Adam
A
Kraszewski
Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznań, Poland.
Jan
J
Barciszewski
Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznań, Poland.
Jerzy
J
Boryski
Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznań, Poland.
Jacek
J
Stawinski
D000241:Adenosine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001932:Brain Neoplasms / Q000188:drug therapy; D003562:Cytidine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D005663:Furans / Q000494:pharmacology; D005909:Glioblastoma / Q000188:drug therapy; D006151:Guanosine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D006367:HeLa Cells; D006801:Humans; D020128:Inhibitory Concentration 50
D000970:Antineoplastic Agents; D005663:Furans; D006151:Guanosine; D003562:Cytidine; D000241:Adenosine