Low Serum Levels of Brain-Derived Neurotrophic Factor Were Associated with Poor Short-Term Functional Outcome and Mortality in Acute Ischemic Stroke.
Circulating brain-derived neurotrophic factor (BDNF) has been highlighted as being a key regulator of rehabilitation-induced recovery after stroke. The aim of this study was to evaluate the association between serum levels of BDNF and functional outcome and mortality events in a 3-month follow-up study in a cohort of patients with an acute ischemic stroke (AIS). From January 2015 to December 2015, consecutive first-ever AIS patients admitted to the Department of Emergency of our hospital were identified. Serum BDNF levels were measured at admission. Functional outcome was evaluated at 3 months using the modified Rankin scale (m-Rankin). We used logistic regression models to assess the relationship between BDNF levels and functional outcome or mortality. In this study, 204 patients were included. Patients with poor outcomes and non-survivors had significantly lower BDNF levels on admission (P < 0.0001 all). Multivariate logistic regression analysis adjusted for common risk factors showed that BDNF levels in the lowest interquartile (≤1st 9.2 ng/ml) was an independent predictor of functional outcome (odds ratios [OR] = 3.75; 95 % confidence interval [CI], 2.43-8.12) and mortality (OR = 4.04; 95 % CI, 2.07-9.14). The area under the receiver operating characteristic curve of BDNF was 0.77 (95 % CI, 0.70-0.84) for functional outcome and 0.79 (95 % CI, 0.71-0.86) for mortality. The findings indicated that low serum levels of BDNF at admission were significantly associated with poor short-term functional outcome and mortality, suggesting that BDNF may serve as a biomarker of poor function outcome after stroke.
Department of Neurosurgery, Tangdu Hospital of Fourth Military Medical University, No.1, Xinsi Road, Baqiao District, Xi'an, Shaanxi Province, 710038, People's Republic of China.
Jing
J
Wang
Department of Neurosurgery, Tangdu Hospital of Fourth Military Medical University, No.1, Xinsi Road, Baqiao District, Xi'an, Shaanxi Province, 710038, People's Republic of China.
Li
L
Gao
Department of Neurosurgery, Tangdu Hospital of Fourth Military Medical University, No.1, Xinsi Road, Baqiao District, Xi'an, Shaanxi Province, 710038, People's Republic of China.
Yan-Long
YL
Yang
Department of Neurosurgery, Tangdu Hospital of Fourth Military Medical University, No.1, Xinsi Road, Baqiao District, Xi'an, Shaanxi Province, 710038, People's Republic of China.
Yu-Qian
YQ
Li
Department of Neurosurgery, Tangdu Hospital of Fourth Military Medical University, No.1, Xinsi Road, Baqiao District, Xi'an, Shaanxi Province, 710038, People's Republic of China.
Tao
T
Chang
Department of Neurosurgery, Tangdu Hospital of Fourth Military Medical University, No.1, Xinsi Road, Baqiao District, Xi'an, Shaanxi Province, 710038, People's Republic of China.
Ming-Hao
MH
Man
Department of Neurosurgery, Tangdu Hospital of Fourth Military Medical University, No.1, Xinsi Road, Baqiao District, Xi'an, Shaanxi Province, 710038, People's Republic of China.
Xing-Ye
XY
Zhang
Department of Neurosurgery, Tangdu Hospital of Fourth Military Medical University, No.1, Xinsi Road, Baqiao District, Xi'an, Shaanxi Province, 710038, People's Republic of China.
Shao-Chun
SC
Guo
Department of Neurosurgery, Tangdu Hospital of Fourth Military Medical University, No.1, Xinsi Road, Baqiao District, Xi'an, Shaanxi Province, 710038, People's Republic of China. lihongli7869@gmail.com.
Li-Hong
LH
Li
D000368:Aged; D015415:Biomarkers / Q000097:blood; D002545:Brain Ischemia / Q000097:blood* / Q000175:diagnosis / Q000401:mortality*; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood*; D003430:Cross-Sectional Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009026:Mortality / Q000639:trends; D020127:Recovery of Function / Q000502:physiology*; D020521:Stroke / Q000097:blood* / Q000175:diagnosis / Q000401:mortality*; D013997:Time Factors; D016896:Treatment Outcome
D015415:Biomarkers; D019208:Brain-Derived Neurotrophic Factor; C579455:BDNF protein, human
Brain-derived neurotrophic factor; Functional outcome; Ischemic stroke; Mortality