Advances in the treatment of rotator cuff lesions by cytokines.
Rotator cuff tears are one of the most common shoulder problems that usually require operative treatments. Therapeutic options used to repair ruptured tendons have consisted of suture, autografts, allografts, and synthetic prostheses. Although surgical treatments have improved dramatically up to now, shoulder pathology is still challenging to orthopedic surgery primarily because these injuries often respond poorly to treatment and require prolonged rehabilitation. Recent attention has focused on several biologic pathways which can augment function to tendon healing, consequently leading to the identification of growth factors involved in this process. In this review, we discuss the studies published in these few years about these growth factors and their role in rotator cuff healing.
Department of Orthopedics, Shanghai Tenth People's Hospital, Tongji University, School of Medicine, ZhabeiArea, Shanghai 200072, China.
Genbin
G
Wu
Department of Orthopedics, Shanghai Tenth People's Hospital, Tongji University, School of Medicine, ZhabeiArea, Shanghai 200072, China.
Peng Cheng
PC
Xu
Institute of Immunology, School of Life Sciences, University of Science and Technology of China, Hefei 230027, Anhui Province, PR China.
Peng
P
Wu
Department of Orthopedics, Shanghai Tenth People's Hospital, Tongji University, School of Medicine, ZhabeiArea, Shanghai 200072, China.
Kaihua
K
Hu
Department of Orthopedics, Shanghai Tenth People's Hospital, Tongji University, School of Medicine, ZhabeiArea, Shanghai 200072, China.
Yeqing
Y
Sun
Department of Orthopedics, Shanghai Tenth People's Hospital, Tongji University, School of Medicine, ZhabeiArea, Shanghai 200072, China, cbiaob@yeah.net.
Biao
B
Cheng
Department of Radiology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200025, China.
Yong
Y
Lu
D003131:Combined Modality Therapy; D016207:Cytokines / Q000502:physiology / Q000627:therapeutic use*; D016179:Granulocyte Colony-Stimulating Factor / Q000502:physiology / Q000627:therapeutic use; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000502:physiology / Q000627:therapeutic use; D007378:Interleukins / Q000502:physiology / Q000627:therapeutic use; D053657:Platelet-Rich Plasma / Q000502:physiology; D000070636:Rotator Cuff Injuries / Q000188:drug therapy* / Q000503:physiopathology / Q000601:surgery; D014945:Wound Healing / Q000187:drug effects / Q000502:physiology
D016207:Cytokines; D036341:Intercellular Signaling Peptides and Proteins; D007378:Interleukins; D016179:Granulocyte Colony-Stimulating Factor