Influence of SaOS-2 cells on corrosion behavior of cast Mg-2.0Zn0.98Mn magnesium alloy.
In this research, the effect of the presence of living cells (SaOS-2) on in vitro degradation of Mg-2.0Zn-0.98Mn (ZM21) magnesium alloy was examined by two methods simple immersion/cell culture tests and electrochemical measurements (electrochemical impedance spectroscopy and potentiodynamic polarization) under cell culture conditions. In immersion/cell culture tests, when SaOS-2 cells were cultured on ZM21 samples, pH of cell culture medium decreased, therefore weight loss and Mg2+ion release from the samples increased. Electrochemical measurements revealed the presence of living cells increased corrosion rate (Icorr) and decreased polarization resistance (Rp) after 48h of incubation. This acceleration of ZM21 corrosion can mainly be attributed to the decrease of medium pH due to cellular metabolic activities.
International Center for Materials Nanoarchitectonics (MANA), National Institute for Materials Science (NIMS), Tsukuba, Ibaraki 305-0044, Japan; Faculty of Materials Science and Engineering, Warsaw University of Technology (WUT), 141 Woloska Street, Warsaw 02-507, Poland.
Agnieszka
A
Witecka
International Center for Materials Nanoarchitectonics (MANA), National Institute for Materials Science (NIMS), Tsukuba, Ibaraki 305-0044, Japan. Electronic address: YAMAMOTO.Akiko@nims.go.jp.
Akiko
A
Yamamoto
Faculty of Materials Science and Engineering, Warsaw University of Technology (WUT), 141 Woloska Street, Warsaw 02-507, Poland.
Wojciech
W
Święszkowski
D000497:Alloys; D001672:Biocompatible Materials / Q000737:chemistry; D018929:Cell Culture Techniques / Q000379:methods; D045744:Cell Line, Tumor; D002478:Cells, Cultured; D003343:Corrosion; D004563:Electrochemistry / Q000379:methods; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007477:Ions; D008274:Magnesium / Q000737:chemistry*; D008345:Manganese / Q000737:chemistry*; D008422:Materials Testing; D011199:Potentiometry; D013053:Spectrophotometry / Q000379:methods; D013499:Surface Properties
D000497:Alloys; D001672:Biocompatible Materials; D007477:Ions; D008345:Manganese; D008274:Magnesium
Biodegradable metals; Biomaterials; Cell culture condition; Electrochemical impedance spectroscopy; Immersion