CORRELATION OF MICROVASCULAR STRUCTURES ON OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY WITH VISUAL ACUITY IN RETINAL VEIN OCCLUSION.
OBJECTIVE
To analyze the correlation of superficial and deep capillary plexuses using optical coherence tomography (OCT) angiography with visual acuity in eyes with retinal vein occlusion (RVO).


METHODS
We retrospectively reviewed the medical records of 33 patients with retinal vein occlusion (RVO; branch retinal vein occlusion in 21 patients, central retinal vein occlusion in 12 patients) and included 33 healthy subjects as a control group, who were evaluated by OCT angiography. The OCT angiography was performed on a 3 mm × 3-mm region centered on the fovea and parafoveal area. The foveal avascular zone (FAZ), and foveal and parafoveal vascular density (VD) in superficial and deep vascular plexuses were analyzed using OCT angiography.


RESULTS
The area of superficial and deep FAZ in eyes with RVO were larger than those in fellow eyes and control eyes (P = 0.034, P = 0.018). The superficial and deep parafoveal VDs in eyes with RVO were significantly lower than those in fellow eyes and control eyes (P = 0.001, P< 0.001). The area of superficial FAZ was negatively correlated with best-corrected visual acuity, and the superficial and deep parafoveal VDs were positively correlated with best-corrected visual acuity. Eighteen of the total 21 eyes with branch retinal vein occlusion (85.7%) showed a high concordance rate with respect to the location of branch retinal vein occlusion and the lowest parafoveal VD area. The multivariate analysis showed that the deep parafoveal VD was associated with best-corrected visual acuity.


CONCLUSIONS
The OCT angiography allows to detect FAZ enlargement, increased parafoveal capillary nonperfusion, and decreased parafoveal VD in eyes with RVO. The area of superficial FAZ and the parafoveal VD are correlated with best-corrected visual acuity in eyes with RVO.
Department of Ophthalmology, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Republic of Korea.
Joon-Won
JW
Kang
Romi
R
Yoo
Youn Hye
YH
Jo
Hyung Chan
HC
Kim
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005260:Female; D005451:Fluorescein Angiography; D005584:Fovea Centralis / Q000098:blood supply / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D055806:Microvessels / Q000000981:diagnostic imaging / Q000473:pathology; D008875:Middle Aged; D012170:Retinal Vein Occlusion / Q000000981:diagnostic imaging* / Q000473:pathology / Q000503:physiopathology; D012171:Retinal Vessels / Q000000981:diagnostic imaging* / Q000473:pathology*; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence / Q000379:methods; D014792:Visual Acuity / Q000502:physiology; D055815:Young Adult