Synthesis of N7-Alkyl-9-deaza-2'-deoxyguanosines Containing Polar N7Chains. Examples of Chemically Stable Analogues of N7-Hydroxyethyl and N7-Oxoethyl Adducts of 2'-Deoxyguanosine.
Development of chemically stable analogues of unstable DNA lesions enables accurate study of polymerase bypass. We report the design and synthesis of N7-hydroxyethyl-9-deaza-2'-deoxyguanosine and N7-oxoethyl-9-deaza-2'-deoxyguanosine as the analogues of N7-hydroxyethyl-2'-deoxyguanosine and N7-oxoethyl-2'-deoxyguanosine, respectively. We also developed the synthesis of these two nucleosides whose N7side chains are protected by TBS for the convenience of conversion to phosphoramidites.
Department of Chemistry and Environmental Science, New Jersey Institute of Technology , Newark, New Jersey 07102, United States.
Xun
X
Gao
4Catalyzer, 530 Old Whitfield Street, Guilford, Connecticut 06437, United States.
Haidong
H
Huang