[Role of M-type phospholipase A2 receptor and its antibody in hepatitis B virus-associated membranous nephropathy].
To examine levels of M-type phospholipase A2 receptor (PLA2R) and its antibody in the patients with hepatitis B virus-associated membranous nephropathy (HBV-MN), and to explore the correlation of PLA2R with laboratory parameters and pathological characteristics.  Methods: A total of 49 adult patients with biopsy-proved HBV-MN were enrolled in this study. Levels of anti-PLA2R antibody in serum and PLA2R in renal tissue were detected. Patients were assigned into two groups: a positive PLA2R group and a negative PLA2R group. Differences in laboratory parameters and pathological characteristics were compared between the two groups.  Results: Of 49 patients with HBV-MN, 17 had positive PLA2R expression in renal tissues. In the positive PLA2R group, 10 patients were positive for serum anti-PLA2R antibody. Patients with positive PLA2R expression in renal tissues showed higher levels of 24 hour urinary protein [(4.6±3.9) g/d], serum HbsAg (70.5%) and renal HbsAg expression (71%), while lower level of serum albumin [(24.1±7.5) g/L] than those of the negative group.  Conclusion: PLA2R is expressed in the renal tissues and serum anti-PLA2R antibody can be detected in some HBV-MN patients. Positive PLA2R expression in renal tissue might be related to HbsAg deposition in serum and renal tissues. Patients with positive PLA2R expression in renal tissue have more severe glomerular sclerosis.
Department of Nephrology, Second Xiangya Hospital;. Institute of Nephrology, Central South University, Changsha 410011, China.
Xiangqing
X
Xu
Department of Nephrology, Second Xiangya Hospital;. Institute of Nephrology, Central South University, Changsha 410011, China.
Xuejing
X
Zhu
Department of Nephrology, Second Xiangya Hospital;. Institute of Nephrology, Central South University, Changsha 410011, China.
Shuguang
S
Yuan
Department of Nephrology, Second Xiangya Hospital;. Institute of Nephrology, Central South University, Changsha 410011, China.
Wenling
W
Jiang
Department of Nephrology, Second Xiangya Hospital;. Institute of Nephrology, Central South University, Changsha 410011, China.
Yuncheng
Y
Xia
Department of Nephrology, Second Xiangya Hospital;. Institute of Nephrology, Central South University, Changsha 410011, China.
Hong
H
Liu
Department of Nephrology, Second Xiangya Hospital;. Institute of Nephrology, Central South University, Changsha 410011, China.
Jun
J
Li
Department of Nephrology, Second Xiangya Hospital;. Institute of Nephrology, Central South University, Changsha 410011, China.
Lin
L
Sun
Department of Nephrology, Second Xiangya Hospital;. Institute of Nephrology, Central South University, Changsha 410011, China.
Youming
Y
Peng
Department of Nephrology, Second Xiangya Hospital;. Institute of Nephrology, Central South University, Changsha 410011, China.
Fuyou
F
Liu
D000328:Adult; D000906:Antibodies; D001323:Autoantibodies / Q000235:genetics / Q000502:physiology; D001706:Biopsy; D015433:Glomerulonephritis, Membranous / Q000150:complications / Q000209:etiology / Q000235:genetics*; D006509:Hepatitis B / Q000150:complications*; D006514:Hepatitis B Surface Antigens / Q000009:adverse effects*; D006515:Hepatitis B virus; D006801:Humans; D007668:Kidney / Q000098:blood supply / Q000737:chemistry / Q000503:physiopathology; D007674:Kidney Diseases / Q000209:etiology* / Q000235:genetics* / Q000503:physiopathology*; D008297:Male; D011379:Prognosis; D011507:Proteinuria / Q000453:epidemiology / Q000235:genetics; D054507:Receptors, Phospholipase A2 / Q000097:blood / Q000502:physiology*; D012709:Serum Albumin / Q000235:genetics
D000906:Antibodies; D001323:Autoantibodies; D006514:Hepatitis B Surface Antigens; D054507:Receptors, Phospholipase A2; D012709:Serum Albumin