Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in psoriasis in southern Turkey.
Psoriasis is a multigenic and multifactorial dermatological disease linked to cardiovascular diseases. Increased levels of homocysteine in patients with psoriasis have been demonstrated in many studies. The most frequently investigated genetic defect that plays a role in homocysteine metabolism is single point substitution (C to T) located on the 677th nucleotide of the methylenetetrahydrofolate reductase gene (MTHFR).
In this study, we aimed to investigate methylenetetrahydrofolate C677T polymorphism in psoriasis patients in Turkey.
The study included 96 patients with psoriasis and 77 controls from southern Turkey. Methylenetetrahydrofolate C677T polymorphism was analysed using the Polymerase Chain Reaction-Restriction Fragment Length Polymorphism methods.
In the psoriasis group, 34 CC (35.4%), 46 CT (47.9%) and 16 TT (16.7%) genotypes were found, respectively; while in the control group, the figures were 39 (50.6%), 35 (45.5%), 3 (3.9%). Homozygote and heterozygote T alleles of methylenetetrahydrofolate C677T polymorphism were significantly higher in the psoriasis than in the control group (p=0.013).
We firstly found a correlation between methylenetetrahydrofolate C677T polymorphism and psoriasis among the southern Turkish population.
Mustafa Kemal University, Medical School - Hatay, Turkey.
Muzeyyen
M
Izmirli
Mustafa Kemal University, Medical School - Hatay, Turkey.
Bilge Bulbul
BB
Sen
Mustafa Kemal University, Medical School - Hatay, Turkey.
Eminenur
E
Rifaioglu
Mustafa Kemal University, Medical School - Hatay, Turkey.
Bulent
B
Gogebakan
Mustafa Kemal University, Medical School - Hatay, Turkey.
Ozgur
O
Aldemir
Mustafa Kemal University, Medical School - Hatay, Turkey.
Tuba
T
Sen
Mustafa Kemal University, Medical School - Hatay, Turkey.
Ozlem
O
Ekiz
Cukurova University, Medical School - Adana, Turkey.
Davut
D
Alptekin
D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length / Q000235:genetics; D011565:Psoriasis / Q000201:enzymology* / Q000235:genetics; D012307:Risk Factors; D014421:Turkey
C573423:MTHFR protein, human; D042965:Methylenetetrahydrofolate Reductase (NADPH2)