Evolution of Papillary Thyroid Carcinoma into Tall Cell Variant and TENIS Syndrome.
We herein report an unusual case of a 55-y-old woman with papillary carcinoma of the thyroid, who presented with multiple recurrences, with its subsequent evolution to tall cell variant and thyroglobulin-elevated negative iodine scintigraphy (TENIS) syndrome. During the course of the disease the lesions became non-iodine-concentrating with an increased proportion of tall cells and evidence of local and distant metastasis. Molecular analysis of the tissue specimen demonstrated BRAFV600Eand I582 M mutations along with upregulation of tumor markers in metastatic tissue. The presence of BRAFV600Emutation and other markers warrants further investigation in future studies to define their precise implications for determining the aggressiveness and development into tall cell variant and TENIS.
Radiation Medicine Centre, BARC, Mumbai, India; and.
Avik
A
Chakraborty
Department of Pathology, Tata Memorial Hospital, Mumbai, India.
S V
SV
Kane
Radiation Medicine Centre, BARC, Mumbai, India; and.
Yogita
Y
Pawer
Radiation Medicine Centre, BARC, Mumbai, India; and drsanb@yahoo.com.
Sandip
S
Basu
D002277:Carcinoma / Q000000981:diagnostic imaging* / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D002291:Carcinoma, Papillary; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009154:Mutation; D048493:Proto-Oncogene Proteins B-raf / Q000235:genetics; D013954:Thyroglobulin / Q000378:metabolism*; D000077273:Thyroid Cancer, Papillary; D013964:Thyroid Neoplasms / Q000000981:diagnostic imaging* / Q000235:genetics / Q000378:metabolism / Q000473:pathology*
D007457:Iodine Radioisotopes; D013954:Thyroglobulin; C482119:BRAF protein, human; D048493:Proto-Oncogene Proteins B-raf
BRAF mutation; lymph node metastasis; multiple recurrences; tall cell variant of PTC