Mechano-Nanoarchitectonics for Bio-Functions at Interfaces.
Architecting well-designed interfacial structures is crucial for fabrication of better bio-related devices such as bio-sensors. A dynamic nature of the interfacial structures with appropriate mechanical properties is advantageous for interactions with bio-related substances. In this short review, a new term, mechano-nanoarchitectonics, has been proposed. This terminology represents nanoarchitectonics methodology for formation of functional structures and regulation of their properties with the aid of mechanical processes. An interfacial two-dimensional environment is an ideal medium to connect macroscopic mechanical actions and nanoscale functions. The review starts with rather traditional topics on how to architect biocomponents at interfaces for bio-reactors and bio-sensors, then covers current active research on mechanical control of bio-functions at dynamic interfaces and emerging topics of mechanical control of DNA origami array and cell differentiation control.
World Premier International (WPI) Research Center for Materials Nanoarchitectonics (MANA), National Institute for Materials Science (NIMS).
Katsuhiko
K
Ariga
D000388:Air; D000818:Animals; D019149:Bioreactors; D015374:Biosensing Techniques; D002454:Cell Differentiation; D002460:Cell Line; D004247:DNA / Q000737:chemistry; D005087:Glucan 1,4-alpha-Glucosidase / Q000737:chemistry; D005947:Glucose / Q000032:analysis; D005949:Glucose Oxidase / Q000737:chemistry; D006801:Humans; D008055:Lipids / Q000737:chemistry; D055595:Mechanical Phenomena; D051379:Mice; D049329:Nanostructures / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods*; D013237:Stereoisomerism; D013314:Stress, Mechanical; D013499:Surface Properties; D013936:Thymidine / Q000737:chemistry; D014529:Uridine / Q000737:chemistry; D014867:Water
D008055:Lipids; D014867:Water; D004247:DNA; D005949:Glucose Oxidase; D005087:Glucan 1,4-alpha-Glucosidase; D005947:Glucose; D013936:Thymidine; D014529:Uridine