Stability of direct oral anticoagulants in whole blood and plasma from patients in steady state treatment.
Using functional haemostasis assays, we demonstrated important differences in stability of direct oral anticoagulants (DOACs) in citrated whole blood and plasma from DOAC treated patients. Laboratories and clinicians should take this into consideration and adjust clinical practices accordingly.
Department of Clinical Biochemistry, Aarhus University Hospital, Denmark.
Rie
R
McGrail
Department of Clinical Biochemistry, Aarhus University Hospital, Denmark.
Jesper
J
Revsholm
Department of Clinical Biochemistry, Aarhus University Hospital, Denmark.
Peter H
PH
Nissen
Department of Cardiology, Aarhus University Hospital, Denmark; Institute of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Erik L
EL
Grove
Department of Clinical Biochemistry, Aarhus University Hospital, Denmark; Institute of Clinical Medicine, Aarhus University, Aarhus, Denmark. Electronic address: am.hvas@dadlnet.dk.
Anne-Mette
AM
Hvas
D000284:Administration, Oral; D000925:Anticoagulants / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D001777:Blood Coagulation / Q000187:drug effects; D001780:Blood Coagulation Tests / Q000379:methods; D000069604:Dabigatran / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D016903:Drug Monitoring / Q000379:methods; D004355:Drug Stability; D006801:Humans; D011720:Pyrazoles / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D011728:Pyridones / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D000069552:Rivaroxaban / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*
D000925:Anticoagulants; D011720:Pyrazoles; D011728:Pyridones; C522181:apixaban; D000069552:Rivaroxaban; D000069604:Dabigatran
Anticoagulants; Apixaban; DOAC; Dabigatran; Drug monitoring; Rivaroxaban