Uric Acid Level and Prevalence of Atrial Fibrillation in a Japanese General Population of 285,882.
The association between serum uric acid (UA) levels and atrial fibrillation (AF) in the general population in Japan is not well known.



In total, 285,882 consecutive subjects (men, 130,897; women, 154,985; age, 58±15 years) not receiving treatment for hyperuricemia who underwent health checkups were enrolled. Subjects were stratified into deciles according to age, body mass index, estimated glomerular filtration rate, systolic blood pressure, and UA level. AF prevalence was calculated for each decile. The odds ratio that defined the decile with the lowest AF prevalence as reference was calculated in each sex. In men, the mean UA was 6.0±1.4 mg/dl; AF prevalence was 1.8% and was lowest in the decile with UA 4.4-4.9 mg/dl. Deciles with both high and low UA (5.4-5.6 mg/dl to >7.8 mg/dl and <4.3 mg/dl) were associated with significantly higher AF prevalence. In women, the mean UA was 4.5±1.1 mg/dl; AF prevalence was 0.7% and was lowest in the decile with UA 3.6-3.8 mg/dl. Deciles with highest UA (5.0-5.2 mg/dl to >5.9 mg/dl) were associated with significantly higher AF prevalence. The analysis adjusted for other clinical covariates demonstrated an independent association between UA and AF in both sexes.



In a representative Japanese general population, UA level was significantly associated with AF, independently of other cardiovascular risk factors. (Circ J 2016; 80: 2453-2459).
Department of Cardiovascular Medicine and Hypertension, Graduate School of Medical and Dental Sciences, Kagoshima University.
Shin
S
Kawasoe
Takuro
T
Kubozono
Shiro
S
Yoshifuku
Satoko
S
Ojima
Naoya
N
Oketani
Masaaki
M
Miyata
Hironori
H
Miyahara
Shigeho
S
Maenohara
Mitsuru
M
Ohishi
D000328:Adult; D000367:Age Factors; D000368:Aged; D044466:Asian People; D001281:Atrial Fibrillation / Q000097:blood* / Q000453:epidemiology*; D015992:Body Mass Index; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D033461:Hyperuricemia / Q000097:blood / Q000453:epidemiology; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D012737:Sex Factors; D014527:Uric Acid / Q000097:blood*
D014527:Uric Acid