Nucleus accumbens deep brain stimulation for a patient with self-injurious behavior and autism spectrum disorder: functional and structural changes of the brain: report of a case and review of literature.
The aim of this report was to investigate the clinical outcome of deep brain stimulation (DBS) for autism spectrum disorder (ASD) and the functional and structural changes in the brain after DBS. We present a 14-year-old boy with ASD and self-injurious behavior (SIB) refractory with medical and behavioral therapy. He was treated by bilateral nucleus accumbens (NAc) DBS. Remarkable clinical improvement was observed following NAc DBS. Brain fluorodeoxyglucose-positron emission tomography (FDG-PET) and magnetic resonance imaging (MRI) volumetric studies revealed that the metabolism in the prefrontal and the frontal cortex as well as the occipital cortex was markedly decreased in association with the decreased cortical volumes in those areas 2 years after NAc DBS. The therapeutic potential of NAc DBS is suggested for the clinical improvement of patients with ASD and SIB with structural and functional changes after DBS.
Department of Neurosurgery, Soonchunhyang University Seoul Hospital, Seoul, South Korea.
Hye Ran
HR
Park
Department of Child and Adolescent Psychiatry, Department of Psychiatry, Seoul National University College of Medicine, Seoul, South Korea.
In Hyang
IH
Kim
Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, South Korea.
Hyejin
H
Kang
Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, South Korea.
Dong Soo
DS
Lee
Department of Child and Adolescent Psychiatry, Department of Psychiatry, Seoul National University College of Medicine, Seoul, South Korea.
Bung-Nyun
BN
Kim
Department of Neurosurgery, Seoul National University College of Medicine, Seoul, South Korea.|Department of Neurosurgery, Seoul National University Hospital, Seoul, 110-744, Republic of Korea.
Dong Gyu
DG
Kim
Department of Neurosurgery, Seoul National University College of Medicine, Seoul, South Korea. paeksh@snu.ac.kr.|Department of Neurosurgery, Seoul National University Hospital, Seoul, 110-744, Republic of Korea. paeksh@snu.ac.kr.
Sun Ha
SH
Paek
D000293:Adolescent; D000067877:Autism Spectrum Disorder / Q000628:therapy*; D002540:Cerebral Cortex / Q000000981:diagnostic imaging*; D046690:Deep Brain Stimulation / Q000379:methods*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009714:Nucleus Accumbens; D049268:Positron-Emission Tomography; D016728:Self-Injurious Behavior / Q000628:therapy*
Autism spectrum disorder; Deep brain stimulation; Nucleus accumbens