Histological factors that predict the liver fibrosis in patients with chronic hepatitis C.
In chronic hepatitis, pathologies reveal a prominent inflammatory infiltrate portal consisting mostly of lymphocytes and plasma cells invading the portal spaces, although one can also identify macrophages, neutrophils or eosinophils. In all the forms of chronic hepatitis, fibrosis starts in the portal area, namely periportally, subsequently extends towards the lobules to the central veins, causing septa, followed by fibrosis. We studied 52 patients with chronic hepatitis C, who underwent a hematological, biochemical, virological and histopathological investigation. We found that the severity degree of the portal inflammation was in direct relation to the hepatitis activity index (HAI) and to the degree of fibrosis. The portal inflammation is dependent to the degree of fibrosis. The degree of inflammation significantly changes the distribution of cases with different degrees of fibrosis (chi-square p=0.00011 <0.001). Periportal inflammation, periportal necrosis and focal necrosis are the morphological aspects of the necroinflammatory process best correlated to the occurrence and development of fibrosis.
Department of Physiology, University of Medicine and Pharmacy of Craiova, Romania; taisescu@yahoo.com.
Ileana Octavia
IO
Petrescu
Viorel
V
Biciuşcă
Citto Iulian
CI
Taisescu
Dragoş Ovidiu
DO
Alexandru
Oana
O
Taisescu
Maria Victoria
MV
Comănescu
Florin
F
Petrescu
Iulian Alin Silviu
IA
Popescu
Diana Maria
DM
Traşcă
Mircea Cătălin
MC
ForŢofoiu
Cristian Adrian
CA
Siloşi
Maria
M
ForŢofoiu
D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D019698:Hepatitis C, Chronic / Q000150:complications* / Q000175:diagnosis*; D006801:Humans; D007249:Inflammation / Q000473:pathology; D008103:Liver Cirrhosis / Q000150:complications* / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D011168:Portal System / Q000473:pathology; D055815:Young Adult