Development of an Exhaled Breath Monitoring System with Semiconductive Gas Sensors, a Gas Condenser Unit, and Gas Chromatograph Columns.
Various volatile organic compounds (VOCs) in breath exhaled by patients with lung cancer, healthy controls, and patients with lung cancer who underwent surgery for resection of cancer were analyzed by gas condenser-equipped gas chromatography-mass spectrometry (GC/MS) for development of an exhaled breath monitoring prototype system involving metal oxide gas sensors, a gas condenser, and gas chromatography columns. The gas condenser-GC/MS analysis identified concentrations of 56 VOCs in the breath exhaled by the test population of 136 volunteers (107 patients with lung cancer and 29 controls), and selected four target VOCs, nonanal, acetoin, acetic acid, and propanoic acid, for use with the condenser, GC, and sensor-type prototype system. The prototype system analyzed exhaled breath samples from 101 volunteers (74 patients with lung cancer and 27 controls). The prototype system exhibited a level of performance similar to that of the gas condenser-GC/MS system for breath analysis.
National Institute of Advanced Industrial Science and Technology (AIST), Shimo-Shidami, Moriyama-ku, Nagoya 463-8560, Japan. itoh-toshio@aist.go.jp.
Toshio
T
Itoh
National Institute of Advanced Industrial Science and Technology (AIST), Shimo-Shidami, Moriyama-ku, Nagoya 463-8560, Japan. t-miwa@glc.shimadzu.co.jp.
Toshio
T
Miwa
National Institute of Advanced Industrial Science and Technology (AIST), Shimo-Shidami, Moriyama-ku, Nagoya 463-8560, Japan. a.tsuruta@aist.go.jp.
Akihiro
A
Tsuruta
National Institute of Advanced Industrial Science and Technology (AIST), Shimo-Shidami, Moriyama-ku, Nagoya 463-8560, Japan. t-akamatsu@aist.go.jp.
Takafumi
T
Akamatsu
National Institute of Advanced Industrial Science and Technology (AIST), Shimo-Shidami, Moriyama-ku, Nagoya 463-8560, Japan. n-izu@aist.go.jp.
Noriya
N
Izu
National Institute of Advanced Industrial Science and Technology (AIST), Shimo-Shidami, Moriyama-ku, Nagoya 463-8560, Japan. w.shin@aist.go.jp.
Woosuck
W
Shin
Aichi Cancer Center, 1-1 Kanokoden, Chikusa-ku, Nagoya 464-8681, Japan. samasama75@gmail.com.
Jangchul
J
Park
Aichi Cancer Center, 1-1 Kanokoden, Chikusa-ku, Nagoya 464-8681, Japan. 107974@aichi-cc.jp.
Toyoaki
T
Hida
Figaro Engineering Inc., 1-5-11 Sembanishi, Minoh, Osaka 562-8505, Japan. eda@figaro.co.jp.
Takeshi
T
Eda
Figaro Engineering Inc., 1-5-11 Sembanishi, Minoh, Osaka 562-8505, Japan. setoguchi@figaro.co.jp.
Yasuhiro
Y
Setoguchi
D000328:Adult; D015374:Biosensing Techniques / Q000379:methods*; D001944:Breath Tests / Q000379:methods*; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D055549:Volatile Organic Compounds / Q000032:analysis
D055549:Volatile Organic Compounds
GC; condenser; exhaled breath analysis; gas condenser-equipped gas chromatography-mass spectrometry; lung cancer; sensor-type prototype system; volatile organic compounds