Coordinated Respiratory Motor Activity in Nerves Innervating the Upper Airway Muscles in Rats.
Maintaining the patency of the upper airway during breathing is of vital importance. The activity of various muscles is related to the patency of the upper airway. In the present study, we examined the respiratory motor activity in the efferent nerves innervating the upper airway muscles to determine the movements of the upper airway during respiration under normocapnic conditions (pH = 7.4) and in hypercapnic acidosis (pH = 7.2). Experiments were performed on arterially perfused decerebrate rats aged between postnatal days 21-35. We recorded the efferent nerve activity in a branch of the cervical spinal nerve innervating the infrahyoid muscles (CN), the hypoglossal nerve (HGN), the external branch of the superior laryngeal nerve (SLN), and the recurrent laryngeal nerve (RLN) with the phrenic nerve (PN). Inspiratory nerve discharges were observed in all these nerves under normocapnic conditions. The onset of inspiratory discharges in the CN and HGN was slightly prior to those in the SLN and RLN. When the CO2 concentration in the perfusate was increased from 5% to 8% to prepare for hypercapnic acidosis, the peak amplitudes of the inspiratory discharges in all the recorded nerves were increased. Moreover, hypercapnic acidosis induced pre-inspiratory discharges in the CN, HGN, SLN, and RLN. The onset of pre-inspiratory discharges in the CN, HGN, and SLN was prior to that of discharges in the RLN. These results suggest that the securing of the airway that occurs a certain time before dilation of the glottis may facilitate ventilation and improve hypercapnic acidosis.
Department of Oral Physiology, Showa University School of Dentistry, Shinagawa-ku, Tokyo 142-8555, Japan.|Department of Perioperative Medicine, Division of Anesthesiology, Showa University School of Dentistry, Oota-ku, Tokyo 145-8515, Japan.
Satoshi
S
Tachikawa
Department of Oral Physiology, Showa University School of Dentistry, Shinagawa-ku, Tokyo 142-8555, Japan.
Kiyomi
K
Nakayama
Department of Oral Physiology, Showa University School of Dentistry, Shinagawa-ku, Tokyo 142-8555, Japan.
Shiro
S
Nakamura
Department of Oral Physiology, Showa University School of Dentistry, Shinagawa-ku, Tokyo 142-8555, Japan.
Ayako
A
Mochizuki
Department of Perioperative Medicine, Division of Anesthesiology, Showa University School of Dentistry, Oota-ku, Tokyo 145-8515, Japan.
Takehiko
T
Iijima
Department of Oral Physiology, Showa University School of Dentistry, Shinagawa-ku, Tokyo 142-8555, Japan.
Tomio
T
Inoue
D000818:Animals; D005260:Female; D006935:Hypercapnia / Q000503:physiopathology; D007002:Hypoglossal Nerve / Q000502:physiology / Q000503:physiopathology; D007823:Laryngeal Nerves / Q000502:physiology / Q000503:physiopathology; D008297:Male; D009132:Muscles / Q000294:innervation* / Q000502:physiology; D010791:Phrenic Nerve / Q000502:physiology / Q000503:physiopathology; D051381:Rats; D017208:Rats, Wistar; D012009:Recurrent Laryngeal Nerve / Q000502:physiology / Q000503:physiopathology; D012119:Respiration; D012137:Respiratory System / Q000294:innervation* / Q000503:physiopathology