Nucleic Acid Delivery for Endothelial Dysfunction in Cardiovascular Diseases.
Endothelial dysfunction has been implicated in the pathophysiology of multiple cardiovascular diseases and involves components of both innate and acquired immune mechanisms. Identifying signature patterns and targets associated with endothelial dysfunction can help in the development of novel nanotherapeutic platforms for treatment of vascular diseases. This review discusses nucleic acid-based regulation of endothelial function and the different nucleic acid-based nanotherapeutic approaches designed to target endothelial dysfunction in cardiovascular disorders.
Northeastern University, Boston, Massachusetts.
Dipti
D
Deshpande
Northeastern University, Boston, Massachusetts.
David R
DR
Janero
Houston Methodist Research Institute, Houston, Texas.
Victor
V
Segura-Ibarra
Houston Methodist Research Institute, Houston, Texas.
Elvin
E
Blanco
Northeastern University, Boston, Massachusetts; King Abdulaziz University, Jeddah, Saudi Arabia.
Mansoor M
MM
Amiji
D002318:Cardiovascular Diseases / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D004730:Endothelium, Vascular / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology*; D006801:Humans; D053758:Nanoparticles; D009696:Nucleic Acids / Q000008:administration & dosage*; D018384:Oxidative Stress
D009696:Nucleic Acids
CVD; DNA damage; cardiovascular diseases; endothelium; inflammation; miRNA; nanoparticle delivery; nucleic acids; oligonucleotide-based therapeutics; oxidative stress