Clinicopathological significance of loss of p27kip1 expression in papillary thyroid carcinoma.
BACKGROUND
A meta-analysis was done to investigate the clinicopathological significance of the loss of p27kip1 expression in papillary thyroid carcinoma (PTC).


METHODS
The meta-analysis involving 17 studies included 1,652 PTC and 328 benign cases. The rate of p27kip1 expression loss in PTC and benign lesions, and the correlations between p27kip1 expression loss and clinicopathological characteristics of PTC were determined.


RESULTS
The estimated rate of p27kip1 expression loss was 0.557 (95% confidence interval [CI] 0.443-0.665) and 0.139 (95% CI 0.062-0.283) in PTC and benign lesions, respectively. In subgroup analysis, the rates of p27kip1 expression loss were 0.683, 0.393, and 0.414 in the classical variant, follicular variant, and papillary thyroid microcarcinoma, respectively. Loss of p27kip1 expression was significantly correlated with lymph node metastasis and distant metastasis (odds ratio 3.559, 95% CI 1.146-11.056 and 4.735, 95% CI 1.322-16.960, respectively). Extrathyroidal extension was correlated with loss of p27kip1 expression, but not in a statistically significant way (p = 0.051). There were no significant correlations between loss of p27kip1 expression and sex, tumor size, BRAFV600E mutation, and tumor multifocality.


CONCLUSIONS
Loss of p27kip1 expression is frequently found in PTC compared with benign lesions and normal thyroid tissue. When present in PTC, it is correlated with aggressive tumor behavior.
Department of Internal Medicine, Eulji University Hospital, Daejeon - Republic of Korea.
Nae Yu
NY
Kim
Department of Endocrinology and Metabolism, Chosun University Hospital, Chosun University School of Medicine, Gwangju - Republic of Korea.|Study group for meta-analysis, Chosun University Hospital, Chosun University School of Medicine, Gwangju - Republic of Korea.
Jin Hwa
JH
Kim
Department of Pathology, Eulji University Hospital, Daejeon - Republic of Korea.
Jung-Soo
JS
Pyo
Department of Urology, Chosun University Hospital, Chosun University School of Medicine, Gwangju - Republic of Korea.|Study group for meta-analysis, Chosun University Hospital, Chosun University School of Medicine, Gwangju - Republic of Korea.
Won
W
Jin Cho
D002291:Carcinoma, Papillary / Q000235:genetics* / Q000473:pathology; D050760:Cyclin-Dependent Kinase Inhibitor p27 / Q000235:genetics*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D009154:Mutation; D011379:Prognosis; D012727:Sex Characteristics; D000077273:Thyroid Cancer, Papillary; D013964:Thyroid Neoplasms / Q000235:genetics* / Q000473:pathology
C436291:CDKN1B protein, human; D050760:Cyclin-Dependent Kinase Inhibitor p27