Flow motion dynamics of microvascular blood flow and oxygenation: Evidence of adaptive changes in obesity and type 2 diabetes mellitus/insulin resistance.
An altered spatial heterogeneity and temporal stability of network perfusion can give rise to a limited adaptive ability to meet metabolic demands. Derangement of local flow motion activity is associated with reduced microvascular blood flow and tissue oxygenation, and it has been suggested that changes in flow motion activity may provide an early indicator of declining, endothelial, neurogenic, and myogenic regulatory mechanisms and signal the onset and progression of microvascular pathophysiology. This short conference review article explores some of the evidence for altered flow motion dynamics of blood flux signals acquired using laser Doppler fluximetry in the skin in individuals at risk of developing or with cardiometabolic disease.
Faculty of Medicine, University of Southampton, Southampton, UK.
Geraldine F
GF
Clough
Faculty of Medicine, University of Southampton, Southampton, UK.|Faculty of Engineering and the Environment, University of Southampton, Southampton, UK.
Katarzyna Z
KZ
Kuliga
Faculty of Engineering and the Environment, University of Southampton, Southampton, UK.
Andrew J
AJ
Chipperfield
D000222:Adaptation, Physiological; D001783:Blood Flow Velocity; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000503:physiopathology*; D006801:Humans; D007333:Insulin Resistance; D017078:Laser-Doppler Flowmetry; D055806:Microvessels / Q000503:physiopathology*; D009765:Obesity / Q000097:blood / Q000503:physiopathology*; D012039:Regional Blood Flow; D012867:Skin / Q000098:blood supply
blood flow; flow motion; frequency analysis; microcirculation; oxygenation