Redox regulation of transient receptor potential channels in the endothelium.
ROS and RNS are important mediators of signaling pathways in the endothelium. Specific members of the TRP superfamily of cation channels act as important Ca2+influx pathways in endothelial cells and are involved in endothelium-dependent vasodilation, regulation of barrier permeability, and angiogenesis. ROS and RNS can modulate the activity of certain TRP channels mainly by modifying specific cysteine residues or by stimulating the production of second messengers. In this review, we highlight the recent literature describing redox regulation of TRP channel activity in endothelial cells as well as the physiological importance of these pathways and implication for cardiovascular diseases.
Department of Pharmacology, Cardiovascular Research Center, Reno School of Medicine, University of Nevada, Reno, NV, USA.
Paulo Wagner
PW
Pires
Department of Pharmacology, Cardiovascular Research Center, Reno School of Medicine, University of Nevada, Reno, NV, USA.
Scott
S
Earley
D000818:Animals; D004730:Endothelium, Vascular / Q000378:metabolism*; D006801:Humans; D010084:Oxidation-Reduction; D026361:Reactive Nitrogen Species / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism; D015290:Second Messenger Systems; D015398:Signal Transduction; D050051:Transient Receptor Potential Channels / Q000378:metabolism*
D026361:Reactive Nitrogen Species; D017382:Reactive Oxygen Species; D050051:Transient Receptor Potential Channels
Ca2+ influx; TRP channels; endothelial cells; redox signaling