Proportion of single-chain recombinant tissue plasminogen activator and outcome after stroke.
OBJECTIVE
To determine whether the ratio single chain (sc)/(sc + 2 chain [tc]) recombinant tissue plasminogen activator (rtPA) influences outcomes in patients with cerebral ischemia.


METHODS
We prospectively included consecutive patients treated with IV rtPA for cerebral ischemia in 13 stroke centers and determined the sc/(sc + tc) ratio in the treatment administered to each patient. We evaluated the outcome with the modified Rankin Scale (mRS) at 3 months (prespecified analysis) and occurrence of epileptic seizures (post hoc analysis). We registered Outcome of Patients Treated by IV Rt-PA for Cerebral Ischaemia According to the Ratio Sc-tPA/Tc-tPA (OPHELIE) under ClinicalTrials.gov identifier no. NCT01614080.


RESULTS
We recruited 1,004 patients (515 men, median age 75 years, median onset-to-needle time 170 minutes, median NIH Stroke Scale score 10). We found no statistical association between sc/(sc + tc) ratios and handicap (mRS > 1), dependency (mRS > 2), or death at 3 months. Patients with symptomatic intracerebral hemorrhages had lower ratios (median 69% vs 72%, adjusted p = 0.003). The sc/(sc + tc) rtPA ratio did not differ between patients with and without seizures, but patients with early seizures were more likely to have received a sc/(sc + tc) rtPA ratio >80.5% (odds ratio 3.61; 95% confidence interval 1.26-10.34).


CONCLUSIONS
The sc/(sc + tc) rtPA ratio does not influence outcomes in patients with cerebral ischemia. The capacity of rtPA to modulate NMDA receptor signaling might be associated with early seizures, but we observed this effect only in patients with a ratio of sc/(sc + tc) rtPA >80.5% in a post hoc analysis.
From Degenerative & Vascular Cognitive Disorders (D.L., C.J., S.M., C.C., T.O., A.-M.M., C.P., H.H., N.D.-P., M.B., C.R., R.B.), Department of Neurology, INSERM U 1171, CHU Lille, Universite Lille; Strokavenir Network (D.L., Y.H., C.J., S.M., I.S., J.-L.M., T.M., M.G., S.S., C.C., E.M.d.B., G.T., T.R., Y.B., O.D., T.O., A.-M.M., P.F., M.Z., A.T.-B., O.O.-W., F.M.M., C.L., A.F., L.L., C.P., M.P., H.H., P.R., N.D.-P., M.B., S.D., C.R., R.B., D.V.), Lille; Inserm UMR-S 919 (Y.H., L.L., D.V.), University Caen-Normandie, GIP Cyceron, Caen; Bordeaux University Hospital (I.S., S.S., M.P., P.R., S.D.), University of Bordeaux; INSERM UMR S894 (J.-L.M., G.T.), Sainte-Anne Hospital, DHU NeuroVasc, Sorbonne Paris Cité, University Paris Descartes; Besançon University Hospital (T.M., E.M.d.B.), University of Franche-Comté; Dijon Stroke Registry (INSERM and INVS) (M.G., Y.B.), Dijon University Hospital, University of Burgundi; University of Rennes (T.R.); University Grenoble Alpes (O.D.); University Hospital Paris Tenon (P.F.); Sorbonne Paris Citéitbonne, University Hospital Paris St Joseph, University Paris Descartes; Rouen University Hospital (A.T.-B., O.O.-W.); University Hospital of Limoges (F.M.M.); Amiens University Hospital (C.L.); and Ste.-Anne Military Teaching Hospital (A.F.), Toulon, France. didier.leys@univ-lille2.fr.
Didier
D
Leys
From Degenerative & Vascular Cognitive Disorders (D.L., C.J., S.M., C.C., T.O., A.-M.M., C.P., H.H., N.D.-P., M.B., C.R., R.B.), Department of Neurology, INSERM U 1171, CHU Lille, Universite Lille; Strokavenir Network (D.L., Y.H., C.J., S.M., I.S., J.-L.M., T.M., M.G., S.S., C.C., E.M.d.B., G.T., T.R., Y.B., O.D., T.O., A.-M.M., P.F., M.Z., A.T.-B., O.O.-W., F.M.M., C.L., A.F., L.L., C.P., M.P., H.H., P.R., N.D.-P., M.B., S.D., C.R., R.B., D.V.), Lille; Inserm UMR-S 919 (Y.H., L.L., D.V.), University Caen-Normandie, GIP Cyceron, Caen; Bordeaux University Hospital (I.S., S.S., M.P., P.R., S.D.), University of Bordeaux; INSERM UMR S894 (J.-L.M., G.T.), Sainte-Anne Hospital, DHU NeuroVasc, Sorbonne Paris Cité, University Paris Descartes; Besançon University Hospital (T.M., E.M.d.B.), University of Franche-Comté; Dijon Stroke Registry (INSERM and INVS) (M.G., Y.B.), Dijon University Hospital, University of Burgundi; University of Rennes (T.R.); University Grenoble Alpes (O.D.); University Hospital Paris Tenon (P.F.); Sorbonne Paris Citéitbonne, University Hospital Paris St Joseph, University Paris Descartes; Rouen University Hospital (A.T.-B., O.O.-W.); University Hospital of Limoges (F.M.M.); Amiens University Hospital (C.L.); and Ste.-Anne Military Teaching Hospital (A.F.), Toulon, France.
Yannick
Y
Hommet
From Degenerative & Vascular Cognitive Disorders (D.L., C.J., S.M., C.C., T.O., A.-M.M., C.P., H.H., N.D.-P., M.B., C.R., R.B.), Department of Neurology, INSERM U 1171, CHU Lille, Universite Lille; Strokavenir Network (D.L., Y.H., C.J., S.M., I.S., J.-L.M., T.M., M.G., S.S., C.C., E.M.d.B., G.T., T.R., Y.B., O.D., T.O., A.-M.M., P.F., M.Z., A.T.-B., O.O.-W., F.M.M., C.L., A.F., L.L., C.P., M.P., H.H., P.R., N.D.-P., M.B., S.D., C.R., R.B., D.V.), Lille; Inserm UMR-S 919 (Y.H., L.L., D.V.), University Caen-Normandie, GIP Cyceron, Caen; Bordeaux University Hospital (I.S., S.S., M.P., P.R., S.D.), University of Bordeaux; INSERM UMR S894 (J.-L.M., G.T.), Sainte-Anne Hospital, DHU NeuroVasc, Sorbonne Paris Cité, University Paris Descartes; Besançon University Hospital (T.M., E.M.d.B.), University of Franche-Comté; Dijon Stroke Registry (INSERM and INVS) (M.G., Y.B.), Dijon University Hospital, University of Burgundi; University of Rennes (T.R.); University Grenoble Alpes (O.D.); University Hospital Paris Tenon (P.F.); Sorbonne Paris Citéitbonne, University Hospital Paris St Joseph, University Paris Descartes; Rouen University Hospital (A.T.-B., O.O.-W.); University Hospital of Limoges (F.M.M.); Amiens University Hospital (C.L.); and Ste.-Anne Military Teaching Hospital (A.F.), Toulon, France.
Clémence
C
Jacquet
From Degenerative & Vascular Cognitive Disorders (D.L., C.J., S.M., C.C., T.O., A.-M.M., C.P., H.H., N.D.-P., M.B., C.R., R.B.), Department of Neurology, INSERM U 1171, CHU Lille, Universite Lille; Strokavenir Network (D.L., Y.H., C.J., S.M., I.S., J.-L.M., T.M., M.G., S.S., C.C., E.M.d.B., G.T., T.R., Y.B., O.D., T.O., A.-M.M., P.F., M.Z., A.T.-B., O.O.-W., F.M.M., C.L., A.F., L.L., C.P., M.P., H.H., P.R., N.D.-P., M.B., S.D., C.R., R.B., D.V.), Lille; Inserm UMR-S 919 (Y.H., L.L., D.V.), University Caen-Normandie, GIP Cyceron, Caen; Bordeaux University Hospital (I.S., S.S., M.P., P.R., S.D.), University of Bordeaux; INSERM UMR S894 (J.-L.M., G.T.), Sainte-Anne Hospital, DHU NeuroVasc, Sorbonne Paris Cité, University Paris Descartes; Besançon University Hospital (T.M., E.M.d.B.), University of Franche-Comté; Dijon Stroke Registry (INSERM and INVS) (M.G., Y.B.), Dijon University Hospital, University of Burgundi; University of Rennes (T.R.); University Grenoble Alpes (O.D.); University Hospital Paris Tenon (P.F.); Sorbonne Paris Citéitbonne, University Hospital Paris St Joseph, University Paris Descartes; Rouen University Hospital (A.T.-B., O.O.-W.); University Hospital of Limoges (F.M.M.); Amiens University Hospital (C.L.); and Ste.-Anne Military Teaching Hospital (A.F.), Toulon, France.
Solène
S
Moulin
From Degenerative & Vascular Cognitive Disorders (D.L., C.J., S.M., C.C., T.O., A.-M.M., C.P., H.H., N.D.-P., M.B., C.R., R.B.), Department of Neurology, INSERM U 1171, CHU Lille, Universite Lille; Strokavenir Network (D.L., Y.H., C.J., S.M., I.S., J.-L.M., T.M., M.G., S.S., C.C., E.M.d.B., G.T., T.R., Y.B., O.D., T.O., A.-M.M., P.F., M.Z., A.T.-B., O.O.-W., F.M.M., C.L., A.F., L.L., C.P., M.P., H.H., P.R., N.D.-P., M.B., S.D., C.R., R.B., D.V.), Lille; Inserm UMR-S 919 (Y.H., L.L., D.V.), University Caen-Normandie, GIP Cyceron, Caen; Bordeaux University Hospital (I.S., S.S., M.P., P.R., S.D.), University of Bordeaux; INSERM UMR S894 (J.-L.M., G.T.), Sainte-Anne Hospital, DHU NeuroVasc, Sorbonne Paris Cité, University Paris Descartes; Besançon University Hospital (T.M., E.M.d.B.), University of Franche-Comté; Dijon Stroke Registry (INSERM and INVS) (M.G., Y.B.), Dijon University Hospital, University of Burgundi; University of Rennes (T.R.); University Grenoble Alpes (O.D.); University Hospital Paris Tenon (P.F.); Sorbonne Paris Citéitbonne, University Hospital Paris St Joseph, University Paris Descartes; Rouen University Hospital (A.T.-B., O.O.-W.); University Hospital of Limoges (F.M.M.); Amiens University Hospital (C.L.); and Ste.-Anne Military Teaching Hospital (A.F.), Toulon, France.
Igor
I
Sibon
From Degenerative & Vascular Cognitive Disorders (D.L., C.J., S.M., C.C., T.O., A.-M.M., C.P., H.H., N.D.-P., M.B., C.R., R.B.), Department of Neurology, INSERM U 1171, CHU Lille, Universite Lille; Strokavenir Network (D.L., Y.H., C.J., S.M., I.S., J.-L.M., T.M., M.G., S.S., C.C., E.M.d.B., G.T., T.R., Y.B., O.D., T.O., A.-M.M., P.F., M.Z., A.T.-B., O.O.-W., F.M.M., C.L., A.F., L.L., C.P., M.P., H.H., P.R., N.D.-P., M.B., S.D., C.R., R.B., D.V.), Lille; Inserm UMR-S 919 (Y.H., L.L., D.V.), University Caen-Normandie, GIP Cyceron, Caen; Bordeaux University Hospital (I.S., S.S., M.P., P.R., S.D.), University of Bordeaux; INSERM UMR S894 (J.-L.M., G.T.), Sainte-Anne Hospital, DHU NeuroVasc, Sorbonne Paris Cité, University Paris Descartes; Besançon University Hospital (T.M., E.M.d.B.), University of Franche-Comté; Dijon Stroke Registry (INSERM and INVS) (M.G., Y.B.), Dijon University Hospital, University of Burgundi; University of Rennes (T.R.); University Grenoble Alpes (O.D.); University Hospital Paris Tenon (P.F.); Sorbonne Paris Citéitbonne, University Hospital Paris St Joseph, University Paris Descartes; Rouen University Hospital (A.T.-B., O.O.-W.); University Hospital of Limoges (F.M.M.); Amiens University Hospital (C.L.); and Ste.-Anne Military Teaching Hospital (A.F.), Toulon, France.
Jean-Louis
JL
Mas
From Degenerative & Vascular Cognitive Disorders (D.L., C.J., S.M., C.C., T.O., A.-M.M., C.P., H.H., N.D.-P., M.B., C.R., R.B.), Department of Neurology, INSERM U 1171, CHU Lille, Universite Lille; Strokavenir Network (D.L., Y.H., C.J., S.M., I.S., J.-L.M., T.M., M.G., S.S., C.C., E.M.d.B., G.T., T.R., Y.B., O.D., T.O., A.-M.M., P.F., M.Z., A.T.-B., O.O.-W., F.M.M., C.L., A.F., L.L., C.P., M.P., H.H., P.R., N.D.-P., M.B., S.D., C.R., R.B., D.V.), Lille; Inserm UMR-S 919 (Y.H., L.L., D.V.), University Caen-Normandie, GIP Cyceron, Caen; Bordeaux University Hospital (I.S., S.S., M.P., P.R., S.D.), University of Bordeaux; INSERM UMR S894 (J.-L.M., G.T.), Sainte-Anne Hospital, DHU NeuroVasc, Sorbonne Paris Cité, University Paris Descartes; Besançon University Hospital (T.M., E.M.d.B.), University of Franche-Comté; Dijon Stroke Registry (INSERM and INVS) (M.G., Y.B.), Dijon University Hospital, University of Burgundi; University of Rennes (T.R.); University Grenoble Alpes (O.D.); University Hospital Paris Tenon (P.F.); Sorbonne Paris Citéitbonne, University Hospital Paris St Joseph, University Paris Descartes; Rouen University Hospital (A.T.-B., O.O.-W.); University Hospital of Limoges (F.M.M.); Amiens University Hospital (C.L.); and Ste.-Anne Military Teaching Hospital (A.F.), Toulon, France.
Thierry
T
Moulin
From Degenerative & Vascular Cognitive Disorders (D.L., C.J., S.M., C.C., T.O., A.-M.M., C.P., H.H., N.D.-P., M.B., C.R., R.B.), Department of Neurology, INSERM U 1171, CHU Lille, Universite Lille; Strokavenir Network (D.L., Y.H., C.J., S.M., I.S., J.-L.M., T.M., M.G., S.S., C.C., E.M.d.B., G.T., T.R., Y.B., O.D., T.O., A.-M.M., P.F., M.Z., A.T.-B., O.O.-W., F.M.M., C.L., A.F., L.L., C.P., M.P., H.H., P.R., N.D.-P., M.B., S.D., C.R., R.B., D.V.), Lille; Inserm UMR-S 919 (Y.H., L.L., D.V.), University Caen-Normandie, GIP Cyceron, Caen; Bordeaux University Hospital (I.S., S.S., M.P., P.R., S.D.), University of Bordeaux; INSERM UMR S894 (J.-L.M., G.T.), Sainte-Anne Hospital, DHU NeuroVasc, Sorbonne Paris Cité, University Paris Descartes; Besançon University Hospital (T.M., E.M.d.B.), University of Franche-Comté; Dijon Stroke Registry (INSERM and INVS) (M.G., Y.B.), Dijon University Hospital, University of Burgundi; University of Rennes (T.R.); University Grenoble Alpes (O.D.); University Hospital Paris Tenon (P.F.); Sorbonne Paris Citéitbonne, University Hospital Paris St Joseph, University Paris Descartes; Rouen University Hospital (A.T.-B., O.O.-W.); University Hospital of Limoges (F.M.M.); Amiens University Hospital (C.L.); and Ste.-Anne Military Teaching Hospital (A.F.), Toulon, France.
Maurice
M
Giroud
From Degenerative & Vascular Cognitive Disorders (D.L., C.J., S.M., C.C., T.O., A.-M.M., C.P., H.H., N.D.-P., M.B., C.R., R.B.), Department of Neurology, INSERM U 1171, CHU Lille, Universite Lille; Strokavenir Network (D.L., Y.H., C.J., S.M., I.S., J.-L.M., T.M., M.G., S.S., C.C., E.M.d.B., G.T., T.R., Y.B., O.D., T.O., A.-M.M., P.F., M.Z., A.T.-B., O.O.-W., F.M.M., C.L., A.F., L.L., C.P., M.P., H.H., P.R., N.D.-P., M.B., S.D., C.R., R.B., D.V.), Lille; Inserm UMR-S 919 (Y.H., L.L., D.V.), University Caen-Normandie, GIP Cyceron, Caen; Bordeaux University Hospital (I.S., S.S., M.P., P.R., S.D.), University of Bordeaux; INSERM UMR S894 (J.-L.M., G.T.), Sainte-Anne Hospital, DHU NeuroVasc, Sorbonne Paris Cité, University Paris Descartes; Besançon University Hospital (T.M., E.M.d.B.), University of Franche-Comté; Dijon Stroke Registry (INSERM and INVS) (M.G., Y.B.), Dijon University Hospital, University of Burgundi; University of Rennes (T.R.); University Grenoble Alpes (O.D.); University Hospital Paris Tenon (P.F.); Sorbonne Paris Citéitbonne, University Hospital Paris St Joseph, University Paris Descartes; Rouen University Hospital (A.T.-B., O.O.-W.); University Hospital of Limoges (F.M.M.); Amiens University Hospital (C.L.); and Ste.-Anne Military Teaching Hospital (A.F.), Toulon, France.
Sharmila
S
Sagnier
From Degenerative & Vascular Cognitive Disorders (D.L., C.J., S.M., C.C., T.O., A.-M.M., C.P., H.H., N.D.-P., M.B., C.R., R.B.), Department of Neurology, INSERM U 1171, CHU Lille, Universite Lille; Strokavenir Network (D.L., Y.H., C.J., S.M., I.S., J.-L.M., T.M., M.G., S.S., C.C., E.M.d.B., G.T., T.R., Y.B., O.D., T.O., A.-M.M., P.F., M.Z., A.T.-B., O.O.-W., F.M.M., C.L., A.F., L.L., C.P., M.P., H.H., P.R., N.D.-P., M.B., S.D., C.R., R.B., D.V.), Lille; Inserm UMR-S 919 (Y.H., L.L., D.V.), University Caen-Normandie, GIP Cyceron, Caen; Bordeaux University Hospital (I.S., S.S., M.P., P.R., S.D.), University of Bordeaux; INSERM UMR S894 (J.-L.M., G.T.), Sainte-Anne Hospital, DHU NeuroVasc, Sorbonne Paris Cité, University Paris Descartes; Besançon University Hospital (T.M., E.M.d.B.), University of Franche-Comté; Dijon Stroke Registry (INSERM and INVS) (M.G., Y.B.), Dijon University Hospital, University of Burgundi; University of Rennes (T.R.); University Grenoble Alpes (O.D.); University Hospital Paris Tenon (P.F.); Sorbonne Paris Citéitbonne, University Hospital Paris St Joseph, University Paris Descartes; Rouen University Hospital (A.T.-B., O.O.-W.); University Hospital of Limoges (F.M.M.); Amiens University Hospital (C.L.); and Ste.-Anne Military Teaching Hospital (A.F.), Toulon, France.
Charlotte
C
Cordonnier
From Degenerative & Vascular Cognitive Disorders (D.L., C.J., S.M., C.C., T.O., A.-M.M., C.P., H.H., N.D.-P., M.B., C.R., R.B.), Department of Neurology, INSERM U 1171, CHU Lille, Universite Lille; Strokavenir Network (D.L., Y.H., C.J., S.M., I.S., J.-L.M., T.M., M.G., S.S., C.C., E.M.d.B., G.T., T.R., Y.B., O.D., T.O., A.-M.M., P.F., M.Z., A.T.-B., O.O.-W., F.M.M., C.L., A.F., L.L., C.P., M.P., H.H., P.R., N.D.-P., M.B., S.D., C.R., R.B., D.V.), Lille; Inserm UMR-S 919 (Y.H., L.L., D.V.), University Caen-Normandie, GIP Cyceron, Caen; Bordeaux University Hospital (I.S., S.S., M.P., P.R., S.D.), University of Bordeaux; INSERM UMR S894 (J.-L.M., G.T.), Sainte-Anne Hospital, DHU NeuroVasc, Sorbonne Paris Cité, University Paris Descartes; Besançon University Hospital (T.M., E.M.d.B.), University of Franche-Comté; Dijon Stroke Registry (INSERM and INVS) (M.G., Y.B.), Dijon University Hospital, University of Burgundi; University of Rennes (T.R.); University Grenoble Alpes (O.D.); University Hospital Paris Tenon (P.F.); Sorbonne Paris Citéitbonne, University Hospital Paris St Joseph, University Paris Descartes; Rouen University Hospital (A.T.-B., O.O.-W.); University Hospital of Limoges (F.M.M.); Amiens University Hospital (C.L.); and Ste.-Anne Military Teaching Hospital (A.F.), Toulon, France.
Elisabeth
E
Medeiros de Bustos
From Degenerative & Vascular Cognitive Disorders (D.L., C.J., S.M., C.C., T.O., A.-M.M., C.P., H.H., N.D.-P., M.B., C.R., R.B.), Department of Neurology, INSERM U 1171, CHU Lille, Universite Lille; Strokavenir Network (D.L., Y.H., C.J., S.M., I.S., J.-L.M., T.M., M.G., S.S., C.C., E.M.d.B., G.T., T.R., Y.B., O.D., T.O., A.-M.M., P.F., M.Z., A.T.-B., O.O.-W., F.M.M., C.L., A.F., L.L., C.P., M.P., H.H., P.R., N.D.-P., M.B., S.D., C.R., R.B., D.V.), Lille; Inserm UMR-S 919 (Y.H., L.L., D.V.), University Caen-Normandie, GIP Cyceron, Caen; Bordeaux University Hospital (I.S., S.S., M.P., P.R., S.D.), University of Bordeaux; INSERM UMR S894 (J.-L.M., G.T.), Sainte-Anne Hospital, DHU NeuroVasc, Sorbonne Paris Cité, University Paris Descartes; Besançon University Hospital (T.M., E.M.d.B.), University of Franche-Comté; Dijon Stroke Registry (INSERM and INVS) (M.G., Y.B.), Dijon University Hospital, University of Burgundi; University of Rennes (T.R.); University Grenoble Alpes (O.D.); University Hospital Paris Tenon (P.F.); Sorbonne Paris Citéitbonne, University Hospital Paris St Joseph, University Paris Descartes; Rouen University Hospital (A.T.-B., O.O.-W.); University Hospital of Limoges (F.M.M.); Amiens University Hospital (C.L.); and Ste.-Anne Military Teaching Hospital (A.F.), Toulon, France.
Guillaume
G
Turc
From Degenerative & Vascular Cognitive Disorders (D.L., C.J., S.M., C.C., T.O., A.-M.M., C.P., H.H., N.D.-P., M.B., C.R., R.B.), Department of Neurology, INSERM U 1171, CHU Lille, Universite Lille; Strokavenir Network (D.L., Y.H., C.J., S.M., I.S., J.-L.M., T.M., M.G., S.S., C.C., E.M.d.B., G.T., T.R., Y.B., O.D., T.O., A.-M.M., P.F., M.Z., A.T.-B., O.O.-W., F.M.M., C.L., A.F., L.L., C.P., M.P., H.H., P.R., N.D.-P., M.B., S.D., C.R., R.B., D.V.), Lille; Inserm UMR-S 919 (Y.H., L.L., D.V.), University Caen-Normandie, GIP Cyceron, Caen; Bordeaux University Hospital (I.S., S.S., M.P., P.R., S.D.), University of Bordeaux; INSERM UMR S894 (J.-L.M., G.T.), Sainte-Anne Hospital, DHU NeuroVasc, Sorbonne Paris Cité, University Paris Descartes; Besançon University Hospital (T.M., E.M.d.B.), University of Franche-Comté; Dijon Stroke Registry (INSERM and INVS) (M.G., Y.B.), Dijon University Hospital, University of Burgundi; University of Rennes (T.R.); University Grenoble Alpes (O.D.); University Hospital Paris Tenon (P.F.); Sorbonne Paris Citéitbonne, University Hospital Paris St Joseph, University Paris Descartes; Rouen University Hospital (A.T.-B., O.O.-W.); University Hospital of Limoges (F.M.M.); Amiens University Hospital (C.L.); and Ste.-Anne Military Teaching Hospital (A.F.), Toulon, France.
Thomas
T
Ronzière
From Degenerative & Vascular Cognitive Disorders (D.L., C.J., S.M., C.C., T.O., A.-M.M., C.P., H.H., N.D.-P., M.B., C.R., R.B.), Department of Neurology, INSERM U 1171, CHU Lille, Universite Lille; Strokavenir Network (D.L., Y.H., C.J., S.M., I.S., J.-L.M., T.M., M.G., S.S., C.C., E.M.d.B., G.T., T.R., Y.B., O.D., T.O., A.-M.M., P.F., M.Z., A.T.-B., O.O.-W., F.M.M., C.L., A.F., L.L., C.P., M.P., H.H., P.R., N.D.-P., M.B., S.D., C.R., R.B., D.V.), Lille; Inserm UMR-S 919 (Y.H., L.L., D.V.), University Caen-Normandie, GIP Cyceron, Caen; Bordeaux University Hospital (I.S., S.S., M.P., P.R., S.D.), University of Bordeaux; INSERM UMR S894 (J.-L.M., G.T.), Sainte-Anne Hospital, DHU NeuroVasc, Sorbonne Paris Cité, University Paris Descartes; Besançon University Hospital (T.M., E.M.d.B.), University of Franche-Comté; Dijon Stroke Registry (INSERM and INVS) (M.G., Y.B.), Dijon University Hospital, University of Burgundi; University of Rennes (T.R.); University Grenoble Alpes (O.D.); University Hospital Paris Tenon (P.F.); Sorbonne Paris Citéitbonne, University Hospital Paris St Joseph, University Paris Descartes; Rouen University Hospital (A.T.-B., O.O.-W.); University Hospital of Limoges (F.M.M.); Amiens University Hospital (C.L.); and Ste.-Anne Military Teaching Hospital (A.F.), Toulon, France.
Yannick
Y
Bejot
From Degenerative & Vascular Cognitive Disorders (D.L., C.J., S.M., C.C., T.O., A.-M.M., C.P., H.H., N.D.-P., M.B., C.R., R.B.), Department of Neurology, INSERM U 1171, CHU Lille, Universite Lille; Strokavenir Network (D.L., Y.H., C.J., S.M., I.S., J.-L.M., T.M., M.G., S.S., C.C., E.M.d.B., G.T., T.R., Y.B., O.D., T.O., A.-M.M., P.F., M.Z., A.T.-B., O.O.-W., F.M.M., C.L., A.F., L.L., C.P., M.P., H.H., P.R., N.D.-P., M.B., S.D., C.R., R.B., D.V.), Lille; Inserm UMR-S 919 (Y.H., L.L., D.V.), University Caen-Normandie, GIP Cyceron, Caen; Bordeaux University Hospital (I.S., S.S., M.P., P.R., S.D.), University of Bordeaux; INSERM UMR S894 (J.-L.M., G.T.), Sainte-Anne Hospital, DHU NeuroVasc, Sorbonne Paris Cité, University Paris Descartes; Besançon University Hospital (T.M., E.M.d.B.), University of Franche-Comté; Dijon Stroke Registry (INSERM and INVS) (M.G., Y.B.), Dijon University Hospital, University of Burgundi; University of Rennes (T.R.); University Grenoble Alpes (O.D.); University Hospital Paris Tenon (P.F.); Sorbonne Paris Citéitbonne, University Hospital Paris St Joseph, University Paris Descartes; Rouen University Hospital (A.T.-B., O.O.-W.); University Hospital of Limoges (F.M.M.); Amiens University Hospital (C.L.); and Ste.-Anne Military Teaching Hospital (A.F.), Toulon, France.
Olivier
O
Detante
From Degenerative & Vascular Cognitive Disorders (D.L., C.J., S.M., C.C., T.O., A.-M.M., C.P., H.H., N.D.-P., M.B., C.R., R.B.), Department of Neurology, INSERM U 1171, CHU Lille, Universite Lille; Strokavenir Network (D.L., Y.H., C.J., S.M., I.S., J.-L.M., T.M., M.G., S.S., C.C., E.M.d.B., G.T., T.R., Y.B., O.D., T.O., A.-M.M., P.F., M.Z., A.T.-B., O.O.-W., F.M.M., C.L., A.F., L.L., C.P., M.P., H.H., P.R., N.D.-P., M.B., S.D., C.R., R.B., D.V.), Lille; Inserm UMR-S 919 (Y.H., L.L., D.V.), University Caen-Normandie, GIP Cyceron, Caen; Bordeaux University Hospital (I.S., S.S., M.P., P.R., S.D.), University of Bordeaux; INSERM UMR S894 (J.-L.M., G.T.), Sainte-Anne Hospital, DHU NeuroVasc, Sorbonne Paris Cité, University Paris Descartes; Besançon University Hospital (T.M., E.M.d.B.), University of Franche-Comté; Dijon Stroke Registry (INSERM and INVS) (M.G., Y.B.), Dijon University Hospital, University of Burgundi; University of Rennes (T.R.); University Grenoble Alpes (O.D.); University Hospital Paris Tenon (P.F.); Sorbonne Paris Citéitbonne, University Hospital Paris St Joseph, University Paris Descartes; Rouen University Hospital (A.T.-B., O.O.-W.); University Hospital of Limoges (F.M.M.); Amiens University Hospital (C.L.); and Ste.-Anne Military Teaching Hospital (A.F.), Toulon, France.
Thavarak
T
Ouk
From Degenerative & Vascular Cognitive Disorders (D.L., C.J., S.M., C.C., T.O., A.-M.M., C.P., H.H., N.D.-P., M.B., C.R., R.B.), Department of Neurology, INSERM U 1171, CHU Lille, Universite Lille; Strokavenir Network (D.L., Y.H., C.J., S.M., I.S., J.-L.M., T.M., M.G., S.S., C.C., E.M.d.B., G.T., T.R., Y.B., O.D., T.O., A.-M.M., P.F., M.Z., A.T.-B., O.O.-W., F.M.M., C.L., A.F., L.L., C.P., M.P., H.H., P.R., N.D.-P., M.B., S.D., C.R., R.B., D.V.), Lille; Inserm UMR-S 919 (Y.H., L.L., D.V.), University Caen-Normandie, GIP Cyceron, Caen; Bordeaux University Hospital (I.S., S.S., M.P., P.R., S.D.), University of Bordeaux; INSERM UMR S894 (J.-L.M., G.T.), Sainte-Anne Hospital, DHU NeuroVasc, Sorbonne Paris Cité, University Paris Descartes; Besançon University Hospital (T.M., E.M.d.B.), University of Franche-Comté; Dijon Stroke Registry (INSERM and INVS) (M.G., Y.B.), Dijon University Hospital, University of Burgundi; University of Rennes (T.R.); University Grenoble Alpes (O.D.); University Hospital Paris Tenon (P.F.); Sorbonne Paris Citéitbonne, University Hospital Paris St Joseph, University Paris Descartes; Rouen University Hospital (A.T.-B., O.O.-W.); University Hospital of Limoges (F.M.M.); Amiens University Hospital (C.L.); and Ste.-Anne Military Teaching Hospital (A.F.), Toulon, France.
Anne-Marie
AM
Mendyk
From Degenerative & Vascular Cognitive Disorders (D.L., C.J., S.M., C.C., T.O., A.-M.M., C.P., H.H., N.D.-P., M.B., C.R., R.B.), Department of Neurology, INSERM U 1171, CHU Lille, Universite Lille; Strokavenir Network (D.L., Y.H., C.J., S.M., I.S., J.-L.M., T.M., M.G., S.S., C.C., E.M.d.B., G.T., T.R., Y.B., O.D., T.O., A.-M.M., P.F., M.Z., A.T.-B., O.O.-W., F.M.M., C.L., A.F., L.L., C.P., M.P., H.H., P.R., N.D.-P., M.B., S.D., C.R., R.B., D.V.), Lille; Inserm UMR-S 919 (Y.H., L.L., D.V.), University Caen-Normandie, GIP Cyceron, Caen; Bordeaux University Hospital (I.S., S.S., M.P., P.R., S.D.), University of Bordeaux; INSERM UMR S894 (J.-L.M., G.T.), Sainte-Anne Hospital, DHU NeuroVasc, Sorbonne Paris Cité, University Paris Descartes; Besançon University Hospital (T.M., E.M.d.B.), University of Franche-Comté; Dijon Stroke Registry (INSERM and INVS) (M.G., Y.B.), Dijon University Hospital, University of Burgundi; University of Rennes (T.R.); University Grenoble Alpes (O.D.); University Hospital Paris Tenon (P.F.); Sorbonne Paris Citéitbonne, University Hospital Paris St Joseph, University Paris Descartes; Rouen University Hospital (A.T.-B., O.O.-W.); University Hospital of Limoges (F.M.M.); Amiens University Hospital (C.L.); and Ste.-Anne Military Teaching Hospital (A.F.), Toulon, France.
Pascal
P
Favrole
From Degenerative & Vascular Cognitive Disorders (D.L., C.J., S.M., C.C., T.O., A.-M.M., C.P., H.H., N.D.-P., M.B., C.R., R.B.), Department of Neurology, INSERM U 1171, CHU Lille, Universite Lille; Strokavenir Network (D.L., Y.H., C.J., S.M., I.S., J.-L.M., T.M., M.G., S.S., C.C., E.M.d.B., G.T., T.R., Y.B., O.D., T.O., A.-M.M., P.F., M.Z., A.T.-B., O.O.-W., F.M.M., C.L., A.F., L.L., C.P., M.P., H.H., P.R., N.D.-P., M.B., S.D., C.R., R.B., D.V.), Lille; Inserm UMR-S 919 (Y.H., L.L., D.V.), University Caen-Normandie, GIP Cyceron, Caen; Bordeaux University Hospital (I.S., S.S., M.P., P.R., S.D.), University of Bordeaux; INSERM UMR S894 (J.-L.M., G.T.), Sainte-Anne Hospital, DHU NeuroVasc, Sorbonne Paris Cité, University Paris Descartes; Besançon University Hospital (T.M., E.M.d.B.), University of Franche-Comté; Dijon Stroke Registry (INSERM and INVS) (M.G., Y.B.), Dijon University Hospital, University of Burgundi; University of Rennes (T.R.); University Grenoble Alpes (O.D.); University Hospital Paris Tenon (P.F.); Sorbonne Paris Citéitbonne, University Hospital Paris St Joseph, University Paris Descartes; Rouen University Hospital (A.T.-B., O.O.-W.); University Hospital of Limoges (F.M.M.); Amiens University Hospital (C.L.); and Ste.-Anne Military Teaching Hospital (A.F.), Toulon, France.
Mathieu
M
Zuber
From Degenerative & Vascular Cognitive Disorders (D.L., C.J., S.M., C.C., T.O., A.-M.M., C.P., H.H., N.D.-P., M.B., C.R., R.B.), Department of Neurology, INSERM U 1171, CHU Lille, Universite Lille; Strokavenir Network (D.L., Y.H., C.J., S.M., I.S., J.-L.M., T.M., M.G., S.S., C.C., E.M.d.B., G.T., T.R., Y.B., O.D., T.O., A.-M.M., P.F., M.Z., A.T.-B., O.O.-W., F.M.M., C.L., A.F., L.L., C.P., M.P., H.H., P.R., N.D.-P., M.B., S.D., C.R., R.B., D.V.), Lille; Inserm UMR-S 919 (Y.H., L.L., D.V.), University Caen-Normandie, GIP Cyceron, Caen; Bordeaux University Hospital (I.S., S.S., M.P., P.R., S.D.), University of Bordeaux; INSERM UMR S894 (J.-L.M., G.T.), Sainte-Anne Hospital, DHU NeuroVasc, Sorbonne Paris Cité, University Paris Descartes; Besançon University Hospital (T.M., E.M.d.B.), University of Franche-Comté; Dijon Stroke Registry (INSERM and INVS) (M.G., Y.B.), Dijon University Hospital, University of Burgundi; University of Rennes (T.R.); University Grenoble Alpes (O.D.); University Hospital Paris Tenon (P.F.); Sorbonne Paris Citéitbonne, University Hospital Paris St Joseph, University Paris Descartes; Rouen University Hospital (A.T.-B., O.O.-W.); University Hospital of Limoges (F.M.M.); Amiens University Hospital (C.L.); and Ste.-Anne Military Teaching Hospital (A.F.), Toulon, France.
Aude
A
Triquenot-Bagan
From Degenerative & Vascular Cognitive Disorders (D.L., C.J., S.M., C.C., T.O., A.-M.M., C.P., H.H., N.D.-P., M.B., C.R., R.B.), Department of Neurology, INSERM U 1171, CHU Lille, Universite Lille; Strokavenir Network (D.L., Y.H., C.J., S.M., I.S., J.-L.M., T.M., M.G., S.S., C.C., E.M.d.B., G.T., T.R., Y.B., O.D., T.O., A.-M.M., P.F., M.Z., A.T.-B., O.O.-W., F.M.M., C.L., A.F., L.L., C.P., M.P., H.H., P.R., N.D.-P., M.B., S.D., C.R., R.B., D.V.), Lille; Inserm UMR-S 919 (Y.H., L.L., D.V.), University Caen-Normandie, GIP Cyceron, Caen; Bordeaux University Hospital (I.S., S.S., M.P., P.R., S.D.), University of Bordeaux; INSERM UMR S894 (J.-L.M., G.T.), Sainte-Anne Hospital, DHU NeuroVasc, Sorbonne Paris Cité, University Paris Descartes; Besançon University Hospital (T.M., E.M.d.B.), University of Franche-Comté; Dijon Stroke Registry (INSERM and INVS) (M.G., Y.B.), Dijon University Hospital, University of Burgundi; University of Rennes (T.R.); University Grenoble Alpes (O.D.); University Hospital Paris Tenon (P.F.); Sorbonne Paris Citéitbonne, University Hospital Paris St Joseph, University Paris Descartes; Rouen University Hospital (A.T.-B., O.O.-W.); University Hospital of Limoges (F.M.M.); Amiens University Hospital (C.L.); and Ste.-Anne Military Teaching Hospital (A.F.), Toulon, France.
Ozlem
O
Ozkul-Wermester
From Degenerative & Vascular Cognitive Disorders (D.L., C.J., S.M., C.C., T.O., A.-M.M., C.P., H.H., N.D.-P., M.B., C.R., R.B.), Department of Neurology, INSERM U 1171, CHU Lille, Universite Lille; Strokavenir Network (D.L., Y.H., C.J., S.M., I.S., J.-L.M., T.M., M.G., S.S., C.C., E.M.d.B., G.T., T.R., Y.B., O.D., T.O., A.-M.M., P.F., M.Z., A.T.-B., O.O.-W., F.M.M., C.L., A.F., L.L., C.P., M.P., H.H., P.R., N.D.-P., M.B., S.D., C.R., R.B., D.V.), Lille; Inserm UMR-S 919 (Y.H., L.L., D.V.), University Caen-Normandie, GIP Cyceron, Caen; Bordeaux University Hospital (I.S., S.S., M.P., P.R., S.D.), University of Bordeaux; INSERM UMR S894 (J.-L.M., G.T.), Sainte-Anne Hospital, DHU NeuroVasc, Sorbonne Paris Cité, University Paris Descartes; Besançon University Hospital (T.M., E.M.d.B.), University of Franche-Comté; Dijon Stroke Registry (INSERM and INVS) (M.G., Y.B.), Dijon University Hospital, University of Burgundi; University of Rennes (T.R.); University Grenoble Alpes (O.D.); University Hospital Paris Tenon (P.F.); Sorbonne Paris Citéitbonne, University Hospital Paris St Joseph, University Paris Descartes; Rouen University Hospital (A.T.-B., O.O.-W.); University Hospital of Limoges (F.M.M.); Amiens University Hospital (C.L.); and Ste.-Anne Military Teaching Hospital (A.F.), Toulon, France.
Francisco Macian
FM
Montoro
From Degenerative & Vascular Cognitive Disorders (D.L., C.J., S.M., C.C., T.O., A.-M.M., C.P., H.H., N.D.-P., M.B., C.R., R.B.), Department of Neurology, INSERM U 1171, CHU Lille, Universite Lille; Strokavenir Network (D.L., Y.H., C.J., S.M., I.S., J.-L.M., T.M., M.G., S.S., C.C., E.M.d.B., G.T., T.R., Y.B., O.D., T.O., A.-M.M., P.F., M.Z., A.T.-B., O.O.-W., F.M.M., C.L., A.F., L.L., C.P., M.P., H.H., P.R., N.D.-P., M.B., S.D., C.R., R.B., D.V.), Lille; Inserm UMR-S 919 (Y.H., L.L., D.V.), University Caen-Normandie, GIP Cyceron, Caen; Bordeaux University Hospital (I.S., S.S., M.P., P.R., S.D.), University of Bordeaux; INSERM UMR S894 (J.-L.M., G.T.), Sainte-Anne Hospital, DHU NeuroVasc, Sorbonne Paris Cité, University Paris Descartes; Besançon University Hospital (T.M., E.M.d.B.), University of Franche-Comté; Dijon Stroke Registry (INSERM and INVS) (M.G., Y.B.), Dijon University Hospital, University of Burgundi; University of Rennes (T.R.); University Grenoble Alpes (O.D.); University Hospital Paris Tenon (P.F.); Sorbonne Paris Citéitbonne, University Hospital Paris St Joseph, University Paris Descartes; Rouen University Hospital (A.T.-B., O.O.-W.); University Hospital of Limoges (F.M.M.); Amiens University Hospital (C.L.); and Ste.-Anne Military Teaching Hospital (A.F.), Toulon, France.
Chantal
C
Lamy
From Degenerative & Vascular Cognitive Disorders (D.L., C.J., S.M., C.C., T.O., A.-M.M., C.P., H.H., N.D.-P., M.B., C.R., R.B.), Department of Neurology, INSERM U 1171, CHU Lille, Universite Lille; Strokavenir Network (D.L., Y.H., C.J., S.M., I.S., J.-L.M., T.M., M.G., S.S., C.C., E.M.d.B., G.T., T.R., Y.B., O.D., T.O., A.-M.M., P.F., M.Z., A.T.-B., O.O.-W., F.M.M., C.L., A.F., L.L., C.P., M.P., H.H., P.R., N.D.-P., M.B., S.D., C.R., R.B., D.V.), Lille; Inserm UMR-S 919 (Y.H., L.L., D.V.), University Caen-Normandie, GIP Cyceron, Caen; Bordeaux University Hospital (I.S., S.S., M.P., P.R., S.D.), University of Bordeaux; INSERM UMR S894 (J.-L.M., G.T.), Sainte-Anne Hospital, DHU NeuroVasc, Sorbonne Paris Cité, University Paris Descartes; Besançon University Hospital (T.M., E.M.d.B.), University of Franche-Comté; Dijon Stroke Registry (INSERM and INVS) (M.G., Y.B.), Dijon University Hospital, University of Burgundi; University of Rennes (T.R.); University Grenoble Alpes (O.D.); University Hospital Paris Tenon (P.F.); Sorbonne Paris Citéitbonne, University Hospital Paris St Joseph, University Paris Descartes; Rouen University Hospital (A.T.-B., O.O.-W.); University Hospital of Limoges (F.M.M.); Amiens University Hospital (C.L.); and Ste.-Anne Military Teaching Hospital (A.F.), Toulon, France.
Anthony
A
Faivre
From Degenerative & Vascular Cognitive Disorders (D.L., C.J., S.M., C.C., T.O., A.-M.M., C.P., H.H., N.D.-P., M.B., C.R., R.B.), Department of Neurology, INSERM U 1171, CHU Lille, Universite Lille; Strokavenir Network (D.L., Y.H., C.J., S.M., I.S., J.-L.M., T.M., M.G., S.S., C.C., E.M.d.B., G.T., T.R., Y.B., O.D., T.O., A.-M.M., P.F., M.Z., A.T.-B., O.O.-W., F.M.M., C.L., A.F., L.L., C.P., M.P., H.H., P.R., N.D.-P., M.B., S.D., C.R., R.B., D.V.), Lille; Inserm UMR-S 919 (Y.H., L.L., D.V.), University Caen-Normandie, GIP Cyceron, Caen; Bordeaux University Hospital (I.S., S.S., M.P., P.R., S.D.), University of Bordeaux; INSERM UMR S894 (J.-L.M., G.T.), Sainte-Anne Hospital, DHU NeuroVasc, Sorbonne Paris Cité, University Paris Descartes; Besançon University Hospital (T.M., E.M.d.B.), University of Franche-Comté; Dijon Stroke Registry (INSERM and INVS) (M.G., Y.B.), Dijon University Hospital, University of Burgundi; University of Rennes (T.R.); University Grenoble Alpes (O.D.); University Hospital Paris Tenon (P.F.); Sorbonne Paris Citéitbonne, University Hospital Paris St Joseph, University Paris Descartes; Rouen University Hospital (A.T.-B., O.O.-W.); University Hospital of Limoges (F.M.M.); Amiens University Hospital (C.L.); and Ste.-Anne Military Teaching Hospital (A.F.), Toulon, France.
Laurent
L
Lebouvier
From Degenerative & Vascular Cognitive Disorders (D.L., C.J., S.M., C.C., T.O., A.-M.M., C.P., H.H., N.D.-P., M.B., C.R., R.B.), Department of Neurology, INSERM U 1171, CHU Lille, Universite Lille; Strokavenir Network (D.L., Y.H., C.J., S.M., I.S., J.-L.M., T.M., M.G., S.S., C.C., E.M.d.B., G.T., T.R., Y.B., O.D., T.O., A.-M.M., P.F., M.Z., A.T.-B., O.O.-W., F.M.M., C.L., A.F., L.L., C.P., M.P., H.H., P.R., N.D.-P., M.B., S.D., C.R., R.B., D.V.), Lille; Inserm UMR-S 919 (Y.H., L.L., D.V.), University Caen-Normandie, GIP Cyceron, Caen; Bordeaux University Hospital (I.S., S.S., M.P., P.R., S.D.), University of Bordeaux; INSERM UMR S894 (J.-L.M., G.T.), Sainte-Anne Hospital, DHU NeuroVasc, Sorbonne Paris Cité, University Paris Descartes; Besançon University Hospital (T.M., E.M.d.B.), University of Franche-Comté; Dijon Stroke Registry (INSERM and INVS) (M.G., Y.B.), Dijon University Hospital, University of Burgundi; University of Rennes (T.R.); University Grenoble Alpes (O.D.); University Hospital Paris Tenon (P.F.); Sorbonne Paris Citéitbonne, University Hospital Paris St Joseph, University Paris Descartes; Rouen University Hospital (A.T.-B., O.O.-W.); University Hospital of Limoges (F.M.M.); Amiens University Hospital (C.L.); and Ste.-Anne Military Teaching Hospital (A.F.), Toulon, France.
Camille
C
Potey
From Degenerative & Vascular Cognitive Disorders (D.L., C.J., S.M., C.C., T.O., A.-M.M., C.P., H.H., N.D.-P., M.B., C.R., R.B.), Department of Neurology, INSERM U 1171, CHU Lille, Universite Lille; Strokavenir Network (D.L., Y.H., C.J., S.M., I.S., J.-L.M., T.M., M.G., S.S., C.C., E.M.d.B., G.T., T.R., Y.B., O.D., T.O., A.-M.M., P.F., M.Z., A.T.-B., O.O.-W., F.M.M., C.L., A.F., L.L., C.P., M.P., H.H., P.R., N.D.-P., M.B., S.D., C.R., R.B., D.V.), Lille; Inserm UMR-S 919 (Y.H., L.L., D.V.), University Caen-Normandie, GIP Cyceron, Caen; Bordeaux University Hospital (I.S., S.S., M.P., P.R., S.D.), University of Bordeaux; INSERM UMR S894 (J.-L.M., G.T.), Sainte-Anne Hospital, DHU NeuroVasc, Sorbonne Paris Cité, University Paris Descartes; Besançon University Hospital (T.M., E.M.d.B.), University of Franche-Comté; Dijon Stroke Registry (INSERM and INVS) (M.G., Y.B.), Dijon University Hospital, University of Burgundi; University of Rennes (T.R.); University Grenoble Alpes (O.D.); University Hospital Paris Tenon (P.F.); Sorbonne Paris Citéitbonne, University Hospital Paris St Joseph, University Paris Descartes; Rouen University Hospital (A.T.-B., O.O.-W.); University Hospital of Limoges (F.M.M.); Amiens University Hospital (C.L.); and Ste.-Anne Military Teaching Hospital (A.F.), Toulon, France.
Mathilde
M
Poli
From Degenerative & Vascular Cognitive Disorders (D.L., C.J., S.M., C.C., T.O., A.-M.M., C.P., H.H., N.D.-P., M.B., C.R., R.B.), Department of Neurology, INSERM U 1171, CHU Lille, Universite Lille; Strokavenir Network (D.L., Y.H., C.J., S.M., I.S., J.-L.M., T.M., M.G., S.S., C.C., E.M.d.B., G.T., T.R., Y.B., O.D., T.O., A.-M.M., P.F., M.Z., A.T.-B., O.O.-W., F.M.M., C.L., A.F., L.L., C.P., M.P., H.H., P.R., N.D.-P., M.B., S.D., C.R., R.B., D.V.), Lille; Inserm UMR-S 919 (Y.H., L.L., D.V.), University Caen-Normandie, GIP Cyceron, Caen; Bordeaux University Hospital (I.S., S.S., M.P., P.R., S.D.), University of Bordeaux; INSERM UMR S894 (J.-L.M., G.T.), Sainte-Anne Hospital, DHU NeuroVasc, Sorbonne Paris Cité, University Paris Descartes; Besançon University Hospital (T.M., E.M.d.B.), University of Franche-Comté; Dijon Stroke Registry (INSERM and INVS) (M.G., Y.B.), Dijon University Hospital, University of Burgundi; University of Rennes (T.R.); University Grenoble Alpes (O.D.); University Hospital Paris Tenon (P.F.); Sorbonne Paris Citéitbonne, University Hospital Paris St Joseph, University Paris Descartes; Rouen University Hospital (A.T.-B., O.O.-W.); University Hospital of Limoges (F.M.M.); Amiens University Hospital (C.L.); and Ste.-Anne Military Teaching Hospital (A.F.), Toulon, France.
Hilde
H
Hénon
From Degenerative & Vascular Cognitive Disorders (D.L., C.J., S.M., C.C., T.O., A.-M.M., C.P., H.H., N.D.-P., M.B., C.R., R.B.), Department of Neurology, INSERM U 1171, CHU Lille, Universite Lille; Strokavenir Network (D.L., Y.H., C.J., S.M., I.S., J.-L.M., T.M., M.G., S.S., C.C., E.M.d.B., G.T., T.R., Y.B., O.D., T.O., A.-M.M., P.F., M.Z., A.T.-B., O.O.-W., F.M.M., C.L., A.F., L.L., C.P., M.P., H.H., P.R., N.D.-P., M.B., S.D., C.R., R.B., D.V.), Lille; Inserm UMR-S 919 (Y.H., L.L., D.V.), University Caen-Normandie, GIP Cyceron, Caen; Bordeaux University Hospital (I.S., S.S., M.P., P.R., S.D.), University of Bordeaux; INSERM UMR S894 (J.-L.M., G.T.), Sainte-Anne Hospital, DHU NeuroVasc, Sorbonne Paris Cité, University Paris Descartes; Besançon University Hospital (T.M., E.M.d.B.), University of Franche-Comté; Dijon Stroke Registry (INSERM and INVS) (M.G., Y.B.), Dijon University Hospital, University of Burgundi; University of Rennes (T.R.); University Grenoble Alpes (O.D.); University Hospital Paris Tenon (P.F.); Sorbonne Paris Citéitbonne, University Hospital Paris St Joseph, University Paris Descartes; Rouen University Hospital (A.T.-B., O.O.-W.); University Hospital of Limoges (F.M.M.); Amiens University Hospital (C.L.); and Ste.-Anne Military Teaching Hospital (A.F.), Toulon, France.
Pauline
P
Renou
From Degenerative & Vascular Cognitive Disorders (D.L., C.J., S.M., C.C., T.O., A.-M.M., C.P., H.H., N.D.-P., M.B., C.R., R.B.), Department of Neurology, INSERM U 1171, CHU Lille, Universite Lille; Strokavenir Network (D.L., Y.H., C.J., S.M., I.S., J.-L.M., T.M., M.G., S.S., C.C., E.M.d.B., G.T., T.R., Y.B., O.D., T.O., A.-M.M., P.F., M.Z., A.T.-B., O.O.-W., F.M.M., C.L., A.F., L.L., C.P., M.P., H.H., P.R., N.D.-P., M.B., S.D., C.R., R.B., D.V.), Lille; Inserm UMR-S 919 (Y.H., L.L., D.V.), University Caen-Normandie, GIP Cyceron, Caen; Bordeaux University Hospital (I.S., S.S., M.P., P.R., S.D.), University of Bordeaux; INSERM UMR S894 (J.-L.M., G.T.), Sainte-Anne Hospital, DHU NeuroVasc, Sorbonne Paris Cité, University Paris Descartes; Besançon University Hospital (T.M., E.M.d.B.), University of Franche-Comté; Dijon Stroke Registry (INSERM and INVS) (M.G., Y.B.), Dijon University Hospital, University of Burgundi; University of Rennes (T.R.); University Grenoble Alpes (O.D.); University Hospital Paris Tenon (P.F.); Sorbonne Paris Citéitbonne, University Hospital Paris St Joseph, University Paris Descartes; Rouen University Hospital (A.T.-B., O.O.-W.); University Hospital of Limoges (F.M.M.); Amiens University Hospital (C.L.); and Ste.-Anne Military Teaching Hospital (A.F.), Toulon, France.
Nelly
N
Dequatre-Ponchelle
From Degenerative & Vascular Cognitive Disorders (D.L., C.J., S.M., C.C., T.O., A.-M.M., C.P., H.H., N.D.-P., M.B., C.R., R.B.), Department of Neurology, INSERM U 1171, CHU Lille, Universite Lille; Strokavenir Network (D.L., Y.H., C.J., S.M., I.S., J.-L.M., T.M., M.G., S.S., C.C., E.M.d.B., G.T., T.R., Y.B., O.D., T.O., A.-M.M., P.F., M.Z., A.T.-B., O.O.-W., F.M.M., C.L., A.F., L.L., C.P., M.P., H.H., P.R., N.D.-P., M.B., S.D., C.R., R.B., D.V.), Lille; Inserm UMR-S 919 (Y.H., L.L., D.V.), University Caen-Normandie, GIP Cyceron, Caen; Bordeaux University Hospital (I.S., S.S., M.P., P.R., S.D.), University of Bordeaux; INSERM UMR S894 (J.-L.M., G.T.), Sainte-Anne Hospital, DHU NeuroVasc, Sorbonne Paris Cité, University Paris Descartes; Besançon University Hospital (T.M., E.M.d.B.), University of Franche-Comté; Dijon Stroke Registry (INSERM and INVS) (M.G., Y.B.), Dijon University Hospital, University of Burgundi; University of Rennes (T.R.); University Grenoble Alpes (O.D.); University Hospital Paris Tenon (P.F.); Sorbonne Paris Citéitbonne, University Hospital Paris St Joseph, University Paris Descartes; Rouen University Hospital (A.T.-B., O.O.-W.); University Hospital of Limoges (F.M.M.); Amiens University Hospital (C.L.); and Ste.-Anne Military Teaching Hospital (A.F.), Toulon, France.
Marie
M
Bodenant
From Degenerative & Vascular Cognitive Disorders (D.L., C.J., S.M., C.C., T.O., A.-M.M., C.P., H.H., N.D.-P., M.B., C.R., R.B.), Department of Neurology, INSERM U 1171, CHU Lille, Universite Lille; Strokavenir Network (D.L., Y.H., C.J., S.M., I.S., J.-L.M., T.M., M.G., S.S., C.C., E.M.d.B., G.T., T.R., Y.B., O.D., T.O., A.-M.M., P.F., M.Z., A.T.-B., O.O.-W., F.M.M., C.L., A.F., L.L., C.P., M.P., H.H., P.R., N.D.-P., M.B., S.D., C.R., R.B., D.V.), Lille; Inserm UMR-S 919 (Y.H., L.L., D.V.), University Caen-Normandie, GIP Cyceron, Caen; Bordeaux University Hospital (I.S., S.S., M.P., P.R., S.D.), University of Bordeaux; INSERM UMR S894 (J.-L.M., G.T.), Sainte-Anne Hospital, DHU NeuroVasc, Sorbonne Paris Cité, University Paris Descartes; Besançon University Hospital (T.M., E.M.d.B.), University of Franche-Comté; Dijon Stroke Registry (INSERM and INVS) (M.G., Y.B.), Dijon University Hospital, University of Burgundi; University of Rennes (T.R.); University Grenoble Alpes (O.D.); University Hospital Paris Tenon (P.F.); Sorbonne Paris Citéitbonne, University Hospital Paris St Joseph, University Paris Descartes; Rouen University Hospital (A.T.-B., O.O.-W.); University Hospital of Limoges (F.M.M.); Amiens University Hospital (C.L.); and Ste.-Anne Military Teaching Hospital (A.F.), Toulon, France.
Sabrina
S
Debruxelles
From Degenerative & Vascular Cognitive Disorders (D.L., C.J., S.M., C.C., T.O., A.-M.M., C.P., H.H., N.D.-P., M.B., C.R., R.B.), Department of Neurology, INSERM U 1171, CHU Lille, Universite Lille; Strokavenir Network (D.L., Y.H., C.J., S.M., I.S., J.-L.M., T.M., M.G., S.S., C.C., E.M.d.B., G.T., T.R., Y.B., O.D., T.O., A.-M.M., P.F., M.Z., A.T.-B., O.O.-W., F.M.M., C.L., A.F., L.L., C.P., M.P., H.H., P.R., N.D.-P., M.B., S.D., C.R., R.B., D.V.), Lille; Inserm UMR-S 919 (Y.H., L.L., D.V.), University Caen-Normandie, GIP Cyceron, Caen; Bordeaux University Hospital (I.S., S.S., M.P., P.R., S.D.), University of Bordeaux; INSERM UMR S894 (J.-L.M., G.T.), Sainte-Anne Hospital, DHU NeuroVasc, Sorbonne Paris Cité, University Paris Descartes; Besançon University Hospital (T.M., E.M.d.B.), University of Franche-Comté; Dijon Stroke Registry (INSERM and INVS) (M.G., Y.B.), Dijon University Hospital, University of Burgundi; University of Rennes (T.R.); University Grenoble Alpes (O.D.); University Hospital Paris Tenon (P.F.); Sorbonne Paris Citéitbonne, University Hospital Paris St Joseph, University Paris Descartes; Rouen University Hospital (A.T.-B., O.O.-W.); University Hospital of Limoges (F.M.M.); Amiens University Hospital (C.L.); and Ste.-Anne Military Teaching Hospital (A.F.), Toulon, France.
Costanza
C
Rossi
From Degenerative & Vascular Cognitive Disorders (D.L., C.J., S.M., C.C., T.O., A.-M.M., C.P., H.H., N.D.-P., M.B., C.R., R.B.), Department of Neurology, INSERM U 1171, CHU Lille, Universite Lille; Strokavenir Network (D.L., Y.H., C.J., S.M., I.S., J.-L.M., T.M., M.G., S.S., C.C., E.M.d.B., G.T., T.R., Y.B., O.D., T.O., A.-M.M., P.F., M.Z., A.T.-B., O.O.-W., F.M.M., C.L., A.F., L.L., C.P., M.P., H.H., P.R., N.D.-P., M.B., S.D., C.R., R.B., D.V.), Lille; Inserm UMR-S 919 (Y.H., L.L., D.V.), University Caen-Normandie, GIP Cyceron, Caen; Bordeaux University Hospital (I.S., S.S., M.P., P.R., S.D.), University of Bordeaux; INSERM UMR S894 (J.-L.M., G.T.), Sainte-Anne Hospital, DHU NeuroVasc, Sorbonne Paris Cité, University Paris Descartes; Besançon University Hospital (T.M., E.M.d.B.), University of Franche-Comté; Dijon Stroke Registry (INSERM and INVS) (M.G., Y.B.), Dijon University Hospital, University of Burgundi; University of Rennes (T.R.); University Grenoble Alpes (O.D.); University Hospital Paris Tenon (P.F.); Sorbonne Paris Citéitbonne, University Hospital Paris St Joseph, University Paris Descartes; Rouen University Hospital (A.T.-B., O.O.-W.); University Hospital of Limoges (F.M.M.); Amiens University Hospital (C.L.); and Ste.-Anne Military Teaching Hospital (A.F.), Toulon, France.
Régis
R
Bordet
From Degenerative & Vascular Cognitive Disorders (D.L., C.J., S.M., C.C., T.O., A.-M.M., C.P., H.H., N.D.-P., M.B., C.R., R.B.), Department of Neurology, INSERM U 1171, CHU Lille, Universite Lille; Strokavenir Network (D.L., Y.H., C.J., S.M., I.S., J.-L.M., T.M., M.G., S.S., C.C., E.M.d.B., G.T., T.R., Y.B., O.D., T.O., A.-M.M., P.F., M.Z., A.T.-B., O.O.-W., F.M.M., C.L., A.F., L.L., C.P., M.P., H.H., P.R., N.D.-P., M.B., S.D., C.R., R.B., D.V.), Lille; Inserm UMR-S 919 (Y.H., L.L., D.V.), University Caen-Normandie, GIP Cyceron, Caen; Bordeaux University Hospital (I.S., S.S., M.P., P.R., S.D.), University of Bordeaux; INSERM UMR S894 (J.-L.M., G.T.), Sainte-Anne Hospital, DHU NeuroVasc, Sorbonne Paris Cité, University Paris Descartes; Besançon University Hospital (T.M., E.M.d.B.), University of Franche-Comté; Dijon Stroke Registry (INSERM and INVS) (M.G., Y.B.), Dijon University Hospital, University of Burgundi; University of Rennes (T.R.); University Grenoble Alpes (O.D.); University Hospital Paris Tenon (P.F.); Sorbonne Paris Citéitbonne, University Hospital Paris St Joseph, University Paris Descartes; Rouen University Hospital (A.T.-B., O.O.-W.); University Hospital of Limoges (F.M.M.); Amiens University Hospital (C.L.); and Ste.-Anne Military Teaching Hospital (A.F.), Toulon, France.
Denis
D
Vivien
D000368:Aged; D000369:Aged, 80 and over; D002545:Brain Ischemia / Q000150:complications / Q000188:drug therapy* / Q000401:mortality; D002543:Cerebral Hemorrhage / Q000150:complications; D004185:Disability Evaluation; D005260:Female; D005343:Fibrinolytic Agents / Q000737:chemistry / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins / Q000737:chemistry / Q000627:therapeutic use; D012640:Seizures / Q000150:complications; D012720:Severity of Illness Index; D020521:Stroke / Q000150:complications / Q000188:drug therapy* / Q000401:mortality; D015912:Thrombolytic Therapy; D061665:Time-to-Treatment; D010959:Tissue Plasminogen Activator / Q000737:chemistry / Q000627:therapeutic use*; D016896:Treatment Outcome
D005343:Fibrinolytic Agents; D011994:Recombinant Proteins; D010959:Tissue Plasminogen Activator