Breast cancer recurrence following radioguided seed localization and standard wire localization of nonpalpable invasive and in situ breast cancers: 5-Year follow-up from a randomized controlled trial.
BACKGROUND
This study compared 5-year breast cancer (BC) recurrence rates in patients randomized to radioguided seed localization (RSL) or wire localization (WL) for non-palpable BC undergoing breast conserving surgery.


METHODS
Chart review of follow-up visits and surveillance imaging was conducted. Data collected included patient and tumour factors, adjuvant therapies and BC recurrence (local recurrence (LR), regional recurrence (RR), and distant metastasis (DM)). Univariate analysis was used.


RESULTS
Follow-up data were available for 298 patients (98%) and median follow-up time was 65 months. There were 11 (4%) cases of BC recurrence and median time to recurrence was 26 months. LR occurred in 8 patients (6 WL and 2 RSL; p = 0.28). Positive margins at first surgery (p = 0.024) and final surgery (p = 0.004) predicted for BC recurrence.


CONCLUSIONS
There was no detectable difference in BC recurrence between WL and RSL groups and positive margins at initial or final surgery both predicted for BC recurrence.
Department of Surgery, McMaster University, St. Joseph's Healthcare, Hamilton, ON, Canada.
Filgen
F
Fung
Department of Surgery, McMaster University, St. Joseph's Healthcare, Hamilton, ON, Canada.
Sylvie D
SD
Cornacchi
Department of Surgical Oncology, Princess Margaret Hospital, University Health Network, Toronto, ON, Canada.
Michael
M
Reedijk
Department of Surgical Oncology, Hamilton Health Sciences and Juravinski Hospital and Cancer Centre, Hamilton, ON, Canada.
Nicole
N
Hodgson
Faculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada; Arthritis Research Canada, Richmond, BC, Canada.
Charlie H
CH
Goldsmith
Department of Surgical Oncology, Princess Margaret Hospital, University Health Network, Toronto, ON, Canada.
David
D
McCready
Department of Pathology, McMaster University, Hamilton, ON, Canada.
Gabriela
G
Gohla
Department of Radiology, McMaster University, Hamilton, ON, Canada.
Colm
C
Boylan
Department of Surgery, McMaster University, St. Joseph's Healthcare, Hamilton, ON, Canada. Electronic address: lovricsp@mcmaster.ca.
Peter J
PJ
Lovrics
D000071960:Breast Carcinoma In Situ / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D018270:Carcinoma, Ductal, Breast / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D005260:Female; D057918:Fiducial Markers; D005500:Follow-Up Studies; D006801:Humans; D007457:Iodine Radioisotopes; D008327:Mammography; D000072662:Margins of Excision; D015412:Mastectomy, Segmental; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D012086:Reoperation; D018084:Ultrasonography, Interventional
D007457:Iodine Radioisotopes
Breast conserving surgery; Distant metastasis; Local recurrence; Needle localization; Radio-guided seed localization; Regional recurrence