Impact of sleep on osteoporosis: sleep quality is associated with bone stiffness index.
The aim of the present study was to investigate the impact of sleep on osteoporosis.



The study used a baseline examination of the Hiroshima Sleep and Healthcare study, which was a cross-sectional and cohort study that addressed the association of sleep habits with lifestyle-related diseases. A total of 1032 participants (25-85 years of age) who underwent health examinations were included. Sleep habits, including its timing (bed time), quantity (time in bed [TIB]), and quality, were assessed using the Pittsburgh Sleep Quality Index (PSQI). The bone stiffness index (SI), a marker of osteoporosis, was measured using quantitative ultrasound systems.



Bed time (r = 0.065, p <0.05), TIB (r = -0.064, p <0.05), and global PSQI score (r = -0.126, p <0.0001) significantly correlated with SI. Multiple regression analyses revealed that after adjusting for age, sex, body mass index, smoking, and alcohol intake, the global PSQI score (β = -0.053, p <0.05) was significantly associated with SI, whereas bed time or TIB was not. Among each component of PSQI, sleep disturbances (β = -0.084, p <0.005) were significantly associated with SI.



Poor sleep quality may be associated with osteoporosis. In particular, increased sleep disturbances may be a key factor in the association between poor sleep quality and osteoporosis.
Health Management and Promotion Center, Hiroshima Atomic Bomb Casualty Council, Hiroshima, Japan. Electronic address: nb7ssk7@sd6.so-net.ne.jp.
Nobuo
N
Sasaki
Health Management and Promotion Center, Hiroshima Atomic Bomb Casualty Council, Hiroshima, Japan.
Saeko
S
Fujiwara
Department of Psychiatry and Neurosciences, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan.
Hidehisa
H
Yamashita
Department of General Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan.
Ryoji
R
Ozono
Department of Internal Medicine, Mitsubishi Mihara Hospital, Mihara, Japan.
Kazushi
K
Teramen
Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan.
Yasuki
Y
Kihara
D000368:Aged; D015519:Bone Density / Q000502:physiology; D001842:Bone and Bones / Q000166:cytology / Q000000981:diagnostic imaging* / Q000378:metabolism; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D006184:Habits; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000150:complications* / Q000000981:diagnostic imaging / Q000503:physiopathology; D012890:Sleep / Q000502:physiology*; D012893:Sleep Wake Disorders / Q000150:complications; D014463:Ultrasonography / Q000379:methods
Osteoporosis; Sleep habits; Sleep quality