The Low Expression of IL-37 Involved in Multiple Myeloma - Associated Angiogenesis.
BACKGROUND Angiogenesis plays a significant role in complex inflammatory and angiogenic processes and is also involved in multiple myeloma (MM) pathogenesis. IL-37 is a proinflammatory cytokine in antitumor activity. Our purpose was to evaluate the IL-37 clinical significance on MM. MATERIAL AND METHODS We measured serum levels of IL-37 in 45 patients with different stages of MM and 30 healthy control subjects and correlated IL-37 with numerous cytokines, such as angiogenesis factors including vascular endothelial growth factor (VEGF) and angiotensin-2 (Ang-2). We also measured the tube formation of human umbilical vein endothelial cells (HUVECs) after pretreatment with recombinant human IL-37 (rhIL-37). RESULTS Serum IL-37 level was lower in the patients with MM than in the healthy control subjects, whereas VEGF and Ang-2 levels were higher, depending on International Staging System stage. Serum IL-37 level had a negative correlation to VEGF and Ang-2 levels, and VEGF had a positive correlation to Ang-2 level. The tube formation of HUVECs was suppressed by the rhIL-37 pretreatment. CONCLUSIONS Our results indicate that serum level of IL-37 plays a part in the pathophysiology of MM progression. Therefore, IL-37 serum level may be a biomarker for disease stage and angiogenesis processes.
Department of Hemotology, Provincial Hospital, Shandong University, Jinan, Shandong, China (mainland).
Zun-Chang
ZC
Li
Department of Hemotology, Binzhou People's Hospital, Binzhou, Shandong, China (mainland).
Ming-Dong
MD
Sun
Department of Hemotology, Binzhou People's Hospital, Binzhou, Shandong, China (mainland).
Yong-Qing
YQ
Zheng
, Binzhou Medical University Hospital, Binzhou, Shandong, China (mainland).
Hong-Jie
HJ
Fu
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D042702:Angiopoietin-2 / Q000378:metabolism; D016022:Case-Control Studies; D003710:Demography; D005260:Female; D061307:Human Umbilical Vein Endothelial Cells / Q000378:metabolism; D006801:Humans; D007375:Interleukin-1 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000097:blood*; D009389:Neovascularization, Pathologic / Q000097:blood*; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
D042702:Angiopoietin-2; C508587:IL37 protein, human; D007375:Interleukin-1; D042461:Vascular Endothelial Growth Factor A