Macrolactam analogues of macrolide natural products.
The chemical modification of macrolide natural products into aza- or lactam analogues is a strategy employed to improve their metabolic stability and biological activity. The methods for the synthesis of several lactam analogues of macrolide natural products are highlighted and aspects of their biological properties presented.
School of Science & Biomedical and Health Innovations Enabling Capability Platform, RMIT University, GPO Box 2476, Melbourne, VIC 3001, Australia. helmut.hugel@rmit.edu.au.
Helmut M
HM
Hügel
Griffith Sciences, Gold Coast campus, Griffith University, QLD 4222, Australia.
Andrew T
AT
Smith
School of Chemistry, the Bio21 Institute, The University of Melbourne, VIC 3010, Australia. masr@unimelb.edu.au.
Mark A
MA
Rizzacasa
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D001688:Biological Products / Q000737:chemistry* / Q000494:pharmacology; D047029:Lactams, Macrocyclic / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D018942:Macrolides / Q000737:chemistry* / Q000494:pharmacology; D008958:Models, Molecular; D008968:Molecular Conformation
D000900:Anti-Bacterial Agents; D001688:Biological Products; D047029:Lactams, Macrocyclic; D018942:Macrolides