Height and Risk of Hip Fracture: A Meta-Analysis of Prospective Cohort Studies.
The association between height and risk of hip fracture has been investigated in several studies, but the evidence is inconclusive. We therefore conducted this meta-analysis of prospective cohort studies to explore whether an association exists between height and risk of hip fracture. We searched PubMed and EMBASE, Web of Science, and the Cochrane Library for studies of height and risk of hip fracture up to February 16, 2016. The random-effects model was used to combine results from individual studies. Seven prospective cohort studies, with 7,478 incident hip fracture cases and 907,913 participants, were included for analysis. The pooled relative risk (RR) was 1.65 (95% confidence interval (CI): 1.26-2.16) comparing the highest with the lowest category of height. Result from dose-response analysis suggested a linear association between height and hip fracture risk (P-nonlinearity = 0.0378). The present evidence suggests that height is positively associated with increased risk of hip fracture. Further well-designed cohort studies are needed to confirm the present findings in other ethnicities.
Department of Orthopaedics, Pu Ai Hospital of Tongji Medical College, Huazhong University of Science and Technology, 473 Hanzheng Street, Qiaokou District, Wuhan 430030, China.
Zhihong
Z
Xiao
Department of Orthopaedics, Pu Ai Hospital of Tongji Medical College, Huazhong University of Science and Technology, 473 Hanzheng Street, Qiaokou District, Wuhan 430030, China.
Dong
D
Ren
Department of Orthopaedics, Pu Ai Hospital of Tongji Medical College, Huazhong University of Science and Technology, 473 Hanzheng Street, Qiaokou District, Wuhan 430030, China.
Wei
W
Feng
Department of Orthopaedics, Pu Ai Hospital of Tongji Medical College, Huazhong University of Science and Technology, 473 Hanzheng Street, Qiaokou District, Wuhan 430030, China.
Yan
Y
Chen
Department of Orthopaedics, Pu Ai Hospital of Tongji Medical College, Huazhong University of Science and Technology, 473 Hanzheng Street, Qiaokou District, Wuhan 430030, China.
Wusheng
W
Kan
Department of Orthopaedics, Pu Ai Hospital of Tongji Medical College, Huazhong University of Science and Technology, 473 Hanzheng Street, Qiaokou District, Wuhan 430030, China.
Danmou
0000-0001-9858-0944
D
Xing
D001827:Body Height; D015331:Cohort Studies; D005260:Female; D006620:Hip Fractures / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology; D006801:Humans; D008297:Male; D008954:Models, Biological; D012307:Risk Factors