Effect of estrogen administration on middle cerebral arterial viscoelastic properties in aged female rats.
To develop a model for studying cerebrovascular disease prevention in elderly women.
Sixty 18-month-old Sprague Dawley (SD) rats were randomly divided into an estrogen administration group (EA, n=30) and a non-administration group (NA, n=30); thirty 4-month-old SD rats were allocated to a control group. The EA group received estradiol benzoate starting on the 5th day of a 34-day breeding period, and the serum levels of estradiol (E2), estrogen receptor (ER), and malondialdehyde (MDA) were measured. The MCA of each group was then sampled for viscoelastic experiments.
The serum levels of E2 and MDA in the EA group showed significant differences compared to those in the control group (p<0.05), while the difference in ER between the EA and control groups was not significant (p>0.05). The decrease in MCA stress at 7,200 s and the increase in strain at 7,200 s in the EA group showed no significant differences compared to the control group (p>0.05).
Estradiol administration inhibited the formation of lipid peroxidation products and restored middle cerebral arterial viscoelasticity in aged female rats.
Doctor, Department of Neurosurgery, Sino-Japanese Friendship Hospital, Jilin University, Changchun, China. Design of the study, manuscript writing, critical revision.
Zhigang
Z
Qin
Master, Department of Otolaryngology, Head and Neck Surgery, Sino-Japanese Friendship Hospital, Jilin University, Changchun, China. Design of the study.
Guijie
G
Li
Doctor, Department of Neurosurgery, Sino-Japanese Friendship Hospital, Jilin University, Changchun, China. Design of the study, manuscript writing, critical revision.
Naijie
N
Liu
Doctor, Department of Neurosurgery, Sino-Japanese Friendship Hospital, Jilin University, Changchun, China. Design of the study, manuscript writing, critical revision.
Conghai
C
Zhao
Doctor, Department of Neurosurgery, Sino-Japanese Friendship Hospital, Jilin University, Changchun, China. Design of the study, manuscript writing, critical revision.
Hang
H
Zhao
D000818:Animals; D004548:Elasticity / Q000187:drug effects; D004958:Estradiol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000494:pharmacology; D004967:Estrogens / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D015227:Lipid Peroxidation / Q000187:drug effects; D008315:Malondialdehyde / Q000097:blood; D020768:Middle Cerebral Artery / Q000187:drug effects* / Q000502:physiology; D011897:Random Allocation; D017207:Rats, Sprague-Dawley; D011959:Receptors, Estradiol / Q000097:blood; D012016:Reference Values; D013997:Time Factors; D014783:Viscosity / Q000187:drug effects
D004967:Estrogens; D011959:Receptors, Estradiol; C074283:estradiol 3-benzoate; D004958:Estradiol; D008315:Malondialdehyde