Effect of Perinatal Bisphenol A Exposure on Serum Lipids and Lipid Enzymes in Offspring Rats of Different Sex.
Rats were exposed to 1 or 10 μg/mL bisphenol A (BPA) in water during pregnancy and lactation. Offspring rats were given normal water and a standard diet from weaning to postnatal day (PND) 50. Perinatal exposure to BPA resulted in significantly increased body weight, visceral adipose tissue, abnormal serum lipids, and lower adiponectin (ADP) levels in both female and male offspring rats. Liver adipose triglyceride lipase (Atgl) mRNA levels and ADP protein in visceral adipose tissue were significantly decreased in BPA-exposed offspring rats. In both female or male offspring rats, obesity and dyslipidemia induced by perinatal exposure to BPA were associated with down regulation of Atgl mRNA in liver and ADP protein in visceral adipose tissue.
Department of Child and Adolescent Health, School of Public Health, China Medical University, Shenyang 110122, Liaoning, China.
Liang
L
Gao
Department of Sports Medicine and Joint Surgery, the First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning, China.
Han Ning
HN
Wang
Department of Child and Adolescent Health, School of Public Health, China Medical University, Shenyang 110122, Liaoning, China.
Ling
L
Zhang
Department of Child and Adolescent Health, School of Public Health, China Medical University, Shenyang 110122, Liaoning, China.
Fang Yuan
FY
Peng
Department of Child and Adolescent Health, School of Public Health, China Medical University, Shenyang 110122, Liaoning, China.
Yue
Y
Jia
Department of Child and Adolescent Health, School of Public Health, China Medical University, Shenyang 110122, Liaoning, China.
Wei
W
Wei
Department of Child and Adolescent Health, School of Public Health, China Medical University, Shenyang 110122, Liaoning, China.
Li Hong
LH
Jia
D052242:Adiponectin / Q000378:metabolism; D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D001559:Benzhydryl Compounds / Q000009:adverse effects* / Q000378:metabolism; D001835:Body Weight; D050171:Dyslipidemias / Q000201:enzymology / Q000209:etiology / Q000378:metabolism* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008049:Lipase / Q000235:genetics / Q000378:metabolism*; D008055:Lipids / Q000097:blood*; D008297:Male; D009765:Obesity / Q000201:enzymology / Q000209:etiology / Q000378:metabolism* / Q000503:physiopathology; D010636:Phenols / Q000009:adverse effects* / Q000378:metabolism; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000201:enzymology / Q000209:etiology / Q000378:metabolism* / Q000503:physiopathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D000098826:Bisphenol A Compounds
D052242:Adiponectin; D001559:Benzhydryl Compounds; D008049:Lipase; D008055:Lipids; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds