Receptor-Binding and Uptake of Binary Actin-ADP-Ribosylating Toxins.
Binary actin-ADP-ribosylating toxins (e.g., Clostridium botulinum C2 toxin or Clostridium perfringens iota toxin ) consist of two separate proteins: An ADP-ribosyltransferase, which modifies actin thereby inhibiting actin polymerization, and a binding component that forms heptamers after proteolytic activation. While C2 toxin interacts with carbohydrate structures on host cells, the group of iota-like toxins binds to lipolysis-stimulated lipoprotein receptor (LSR). Here, we review LSR and discuss the role and function of LSR in interaction of iota-like toxins with host cells.
Institute for Experimental and Clinical Pharmacology and Toxicology, Albert-Ludwigs University of Freiburg, Albertstr. 25, 79104, Freiburg, Germany.
Panagiotis
P
Papatheodorou
Institute for Experimental and Clinical Pharmacology and Toxicology, Albert-Ludwigs University of Freiburg, Albertstr. 25, 79104, Freiburg, Germany. klaus.aktories@pharmakol.uni-freiburg.de.
Klaus
K
Aktories
D036002:ADP Ribose Transferases / Q000378:metabolism*; D000199:Actins / Q000378:metabolism*; D000244:Adenosine Diphosphate / Q000378:metabolism; D001427:Bacterial Toxins / Q000378:metabolism*; D001905:Botulinum Toxins / Q000378:metabolism; D011485:Protein Binding; D021381:Protein Transport
D000199:Actins; D001427:Bacterial Toxins; D000244:Adenosine Diphosphate; D036002:ADP Ribose Transferases; D001905:Botulinum Toxins