Lipoprotein(a) in patients with hepatocellular carcinoma and portal vein thrombosis.
BACKGROUND
The mechanism for hypercoagulability in malignancy is not entirely understood. Although several studies report contrasting finding about the link between elevated plasma levels of the lipoprotein(a) [Lp(a)] and the possible recurrence of venous thromboembolism, we perform a study to evaluate the impact of the Lp(a) in the development of portal vein thromboembolism (PVT) in patients with HCC.


METHODS
We compared 44 PVT patients with 50 healthy subjects and 50 HCC patients.


RESULTS
The comparison between PVT patients and HCC showed in the former the mean value of serum lipoprotein levels was higher than 37.3 mg/dl (p = 0.000). The comparison between PVT versus healthy controls showed that in the former, mean value of serum lipoprotein levels was higher than 75 mg/dl (p = 0.000). The predictive value test of serum lipoprotein(a) on PVT was 0.72 and on HCC was 0.83. The odds ratio of lipoprotein(a) was 9.21 on PVT and 6.33 on HCC.


CONCLUSIONS
Patients with PVT and HCC showed a statistical significant serum lipoprotein(a) level higher than the subjects with HCC and no PVT or the healthy subject. So we assume a role of lipoprotein(a) as predictor of venous thromboembolism in neoplastic patients.
Department of Biomedical and Biotechnological Science, University of Catania, Catania, Italy.
Giulia
G
Malaguarnera
Department of Medical, Surgical Sciences and Advanced Technologies "G.F. Ingrassia", University of Catania, Via S. Sofia 78, 95123, Catania, Italy. vito.catania@policlinico.unict.it.
Vito Emanuele
VE
Catania
Research Center "The Great Senescence", University of Catania, Catania, Italy.
Antonio
A
Francaviglia
Department of Biomedical and Biotechnological Science, University of Catania, Catania, Italy.
Michele
M
Malaguarnera
Department of Biomedical and Biotechnological Science, University of Catania, Catania, Italy.
Filippo
F
Drago
Department of Experimental and Clinical Medicine, University of Catania, Catania, Italy.
Massimo
M
Motta
Department of Medical, Surgical Sciences and Advanced Technologies "G.F. Ingrassia", University of Catania, Via S. Sofia 78, 95123, Catania, Italy.
Saverio
S
Latteri
D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000097:blood / Q000150:complications / Q000473:pathology; D005260:Female; D006801:Humans; D017270:Lipoprotein(a) / Q000032:analysis / Q000097:blood*; D008113:Liver Neoplasms / Q000097:blood / Q000150:complications / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011169:Portal Vein / Q000000981:diagnostic imaging*; D011237:Predictive Value of Tests; D013223:Statistics as Topic; D018608:Ultrasonography, Doppler / Q000379:methods; D020246:Venous Thrombosis / Q000097:blood / Q000175:diagnosis / Q000209:etiology
D017270:Lipoprotein(a)
Atherosclerosis; HCC; Lipoprotein(a); PVT; Venous thromboembolism