PyBidine-Ni(OAc)2-Catalyzed Michael/Aldol Reaction of Methyleneindolinones and Thiosalicylaldehydes for Stereochemically Divergent Thiochromanyl-spirooxindoles.
(S,S)-Diphenylethylenediamine-derived bis(imidazolidine)pyridine (PyBidine)-Ni(OAc)2complex catalyzed the asymmetric Michael/aldol reaction of methyleneindolinone and thiosalicylaldehyde to produce (2'R,3S,4'R)-thiochromanyl-spirooxindole having three contiguous stereogenic centers.
Molecular Chirality Research Center, and Department of Chemistry, Graduate School of Science and ‡Center for Analytical Instrumentation, Chiba University , 1-33 Yayoi, Inage, Chiba 263-8522, Japan.
Takayoshi
T
Arai
Molecular Chirality Research Center, and Department of Chemistry, Graduate School of Science and ‡Center for Analytical Instrumentation, Chiba University , 1-33 Yayoi, Inage, Chiba 263-8522, Japan.
Tomoya
T
Miyazaki
Molecular Chirality Research Center, and Department of Chemistry, Graduate School of Science and ‡Center for Analytical Instrumentation, Chiba University , 1-33 Yayoi, Inage, Chiba 263-8522, Japan.
Hiroki
H
Ogawa
Molecular Chirality Research Center, and Department of Chemistry, Graduate School of Science and ‡Center for Analytical Instrumentation, Chiba University , 1-33 Yayoi, Inage, Chiba 263-8522, Japan.
Hyuma
H
Masu