Ambient air pollution, traffic noise and adult asthma prevalence: a BioSHaRE approach.
We investigated the effects of both ambient air pollution and traffic noise on adult asthma prevalence, using harmonised data from three European cohort studies established in 2006-2013 (HUNT3, Lifelines and UK Biobank).Residential exposures to ambient air pollution (particulate matter with aerodynamic diameter ≤10 µm (PM10) and nitrogen dioxide (NO2)) were estimated by a pan-European Land Use Regression model for 2007. Traffic noise for 2009 was modelled at home addresses by adapting a standardised noise assessment framework (CNOSSOS-EU). A cross-sectional analysis of 646 731 participants aged ≥20 years was undertaken using DataSHIELD to pool data for individual-level analysis via a "compute to the data" approach. Multivariate logistic regression models were fitted to assess the effects of each exposure on lifetime and current asthma prevalence.PM10or NO2higher by 10 µg·m-3was associated with 12.8% (95% CI 9.5-16.3%) and 1.9% (95% CI 1.1-2.8%) higher lifetime asthma prevalence, respectively, independent of confounders. Effects were larger in those aged ≥50 years, ever-smokers and less educated. Noise exposure was not significantly associated with asthma prevalence.This study suggests that long-term ambient PM10exposure is associated with asthma prevalence in western European adults. Traffic noise is not associated with asthma prevalence, but its potential to impact on asthma exacerbations needs further investigation.
MRC-PHE Centre for Environment and Health, Dept of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK yutong.cai@imperial.ac.uk.
Yutong
Y
Cai
Dept of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Wilma L
WL
Zijlema
Research Institute of the McGill University Health Centre and Dept of Medicine, McGill University, Montreal, QC, Canada.
Dany
D
Doiron
MRC-PHE Centre for Environment and Health, Dept of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
Marta
M
Blangiardo
Data to Knowledge (D2K) Research Group, University of Bristol, Bristol, UK.|Public Population Project in Genomics and Society (P3G), Montreal, QC, Canada.
Paul R
PR
Burton
Research Institute of the McGill University Health Centre and Dept of Medicine, McGill University, Montreal, QC, Canada.
Isabel
I
Fortier
Metabolic, Cardiovascular and Inflammatory Disease Genomics Branch, National Human Genome Research Institute, Bethesda, MD, USA.
Amadou
A
Gaye
MRC-PHE Centre for Environment and Health, Dept of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
John
J
Gulliver
MRC-PHE Centre for Environment and Health, Dept of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.|Swiss Tropical and Public Health Institute, Basel, Switzerland.|University of Basel, Basel, Switzerland.
Kees
K
de Hoogh
Dept of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim, Norway.
Kristian
K
Hveem
Research Institute of the McGill University Health Centre and Dept of Medicine, McGill University, Montreal, QC, Canada.
Stéphane
S
Mbatchou
MRC-PHE Centre for Environment and Health, Dept of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
David W
DW
Morley
Dept of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Ronald P
RP
Stolk
MRC-PHE Centre for Environment and Health, Dept of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
Paul
P
Elliott
MRC-PHE Centre for Environment and Health, Dept of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.|Directorate of Public Health and Primary Care, Imperial College Healthcare NHS Trust, London, UK.
Anna L
AL
Hansell
MRC-PHE Centre for Environment and Health, Dept of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
Susan
S
Hodgson
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000393:Air Pollutants / Q000032:analysis; D000397:Air Pollution / Q000009:adverse effects*; D001249:Asthma / Q000453:epidemiology*; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D004781:Environmental Exposure; D004784:Environmental Monitoring; D005062:European Union; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009585:Nitrogen Dioxide / Q000032:analysis; D009622:Noise / Q000009:adverse effects*; D052638:Particulate Matter / Q000032:analysis*; D014186:Transportation; D055815:Young Adult
D000393:Air Pollutants; D052638:Particulate Matter; D009585:Nitrogen Dioxide