Impact of Anti-Inflammatory Drugs on Pyogenic Vertebral Osteomyelitis: A Prospective Cohort Study.
Objective. Pyogenic vertebral osteomyelitis (PVO) are frequently misdiagnosed and patients often receive anti-inflammatory drugs for their back pain. We studied the impact of these medications.Methods. We performed a prospective study enrolling patients with PVO and categorized them depending on their drugs intake. Then, we compared diagnosis delay, clinical presentation at hospitalization, incidence of complications, and cure rate.Results. In total, 79 patients were included. Multivariate analysis found no correlation between anti-inflammatory drug intake and diagnosis delay, clinical presentation, complications, or outcome.Conclusion. Anti-inflammatory drugs intake does not affect diagnostic delay, severity at diagnosis, or complications of PVO.
Infectious Diseases Unit, University Hospital R. Poincaré, APHP, Versailles Saint Quentin University, Garches, France.
Aurélien
0000-0002-5843-4819
A
Dinh
Infectious Diseases Unit, University Hospital R. Poincaré, APHP, Versailles Saint Quentin University, Garches, France.
Maxime
M
Jean
Pharmacy Department, University Hospital R. Poincaré, APHP, Versailles Saint Quentin University, Garches, France.
Frédérique
F
Bouchand
Infectious Diseases Unit, University Hospital R. Poincaré, APHP, Versailles Saint Quentin University, Garches, France.
Benjamin
B
Davido
Infectious Diseases Unit, University Hospital R. Poincaré, APHP, Versailles Saint Quentin University, Garches, France.
Alexis
A
Descatha
Infectious Diseases Unit, University Hospital R. Poincaré, APHP, Versailles Saint Quentin University, Garches, France.
Clara
C
Duran
Infectious Diseases Unit, University Hospital of Bretonneau, Denis Diderot University, Tours, France.
Guillaume
G
Gras
Infectious Diseases Unit, University Hospital R. Poincaré, APHP, Versailles Saint Quentin University, Garches, France.
Christian
C
Perronne
Rheumatology Department, University Hospital of Bretonneau, Denis Diderot University, Tours, France.
Denis
D
Mulleman
Infectious Diseases Unit, University Hospital R. Poincaré, APHP, Versailles Saint Quentin University, Garches, France.
Jérôme
J
Salomon
Infectious Diseases Unit, University Hospital of Bretonneau, Denis Diderot University, Tours, France.
Louis
L
Bernard