Cell Signalling: Combining Pathways for Diversification and Reproducibility.
How a given signalling pathway can generate diverse outcomes is an open question. A new study shows that EGFR signalling in combination with JAK/STAT or BMP pathways induces different cell fates. Antagonistic interactions between downstream targets further stabilizes epithelial patterning.
Centro Andaluz de Biología del Desarrollo, CSIC/JA/Universidad Pablo de Olavide, Seville, Spain. Electronic address: jcashom@upo.es.
James
J
Castelli-Gair Hombría
Centro Andaluz de Biología del Desarrollo, CSIC/JA/Universidad Pablo de Olavide, Seville, Spain.
Acaimo
A
González-Reyes
D066246:ErbB Receptors; D053612:Janus Kinases; D015203:Reproducibility of Results; D050791:STAT Transcription Factors; D015398:Signal Transduction
D050791:STAT Transcription Factors; D066246:ErbB Receptors; D053612:Janus Kinases