When Clinical Trial Participation Is Not an Option in the Era of Personalized Medicine: The Case of Two Patients.
The combination of personalized therapy with immunotherapy might lead to rapid complete remission in patients who are too sick to be eligible for clinical trials. We report 2 such extraordinary responders. A discussion on the use and purpose of clinical trials in this new era of very active anticancer drug discovery concludes that a paradigm shift is urgently needed.
University of Vermont Cancer Center, Burlington, Vt., USA.
Claire F
CF
Verschraegen
Hibba
H
Rehman
Bhargavi
B
Pulluri
James
J
DeKay
Maura
M
Barry
Edmund
E
Folefac
Kim
K
Dittus
Chris
C
Holmes
Julian
J
Sprague
Steve
S
Ades
Pam C
PC
Gibson
D000368:Aged; D002986:Clinical Trials as Topic / Q000379:methods*; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary / Q000628:therapy*; D008297:Male; D008545:Melanoma / Q000473:pathology / Q000628:therapy*; D008875:Middle Aged; D057285:Precision Medicine / Q000379:methods*; D012878:Skin Neoplasms / Q000473:pathology / Q000628:therapy*; D065646:Thyroid Carcinoma, Anaplastic / Q000628:therapy*