Outcome of Acute Pancreatic and Peripancreatic Collections Occurring in Patients With Acute Pancreatitis.
To study the outcome of acute collections occurring in patients with acute pancreatitis BACKGROUND:: There are limited data on natural history of acute collections arising after acute pancreatitis (AP).



Consecutive patients of AP admitted between July 2011 and December 2012 were evaluated by imaging for development of acute collections as defined by revised Atlanta classification. Imaging was repeated at 1 and 3 months. Spontaneous resolution, evolution, and need for intervention were assessed.



Of the 189 patients, 151 patients (79.9%) had acute collections with severe disease and delayed hospitalization being predictors of acute collections. Thirty-six patients had acute interstitial edematous pancreatitis, 8 of whom developed acute peripancreatic fluid collections, of which 1 evolved into pseudocyst. Among the 153 patients with acute necrotizing pancreatitis, 143 (93.4%) developed acute necrotic collection (ANC). Twenty-three of 143 ANC patients died, 21 had resolved collections, whereas 84 developed walled-off necrosis (WON), with necrosis >30% (P = 0.010) and Computed Tomographic Severity Index score ≥7 (P = 0.048) predicting development of WON. Of the 84 patients with WON, 8 expired, 53 patients required an intervention, and 23 were managed conservatively. Independent predictors of any intervention among all patients were Computed Tomographic Severity Index score ≥7 (P < 0.001) and interval between onset of pain to hospitalization >7 days (P = 0.04).



Patients with severe AP and delayed hospitalization more often develop acute collections. Pancreatic pseudocysts are a rarity in acute interstitial pancreatitis. A majority of patients with necrotising pancreatitis will develop ANC, more than half of whom will develop WON. Delay in hospitalization and higher baseline necrosis score predict need for intervention.
Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Manish
M
Manrai
Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Rakesh
R
Kochhar
Department of Surgery, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Vikas
V
Gupta
Department of Surgery, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Thakur Deen
TD
Yadav
Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Narendra
N
Dhaka
Department of Radiodiagnosis, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Naveen
N
Kalra
Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Saroj K
SK
Sinha
Department of Radiodiagnosis, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Niranjan
N
Khandelwal
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003131:Combined Modality Therapy; D000072700:Conservative Treatment / Q000379:methods; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006760:Hospitalization; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000000981:diagnostic imaging / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D011379:Prognosis; D011446:Prospective Studies; D012075:Remission, Spontaneous; D012720:Severity of Illness Index; D014057:Tomography, X-Ray Computed; D055815:Young Adult