A method to study the hemodynamics of chicken embryo's aortic arches using optical coherence tomography.
Congenital cardiovascular defects are the leading cause of birth defect related death. It has been hypothesized that fluid mechanical forces of embryonic blood flow affect cardiovascular development and play a role in congenital malformations. Studies in small animal embryos can improve our understanding of congenital malformations and can lead to better treatment. We present a feasibility study in which high-resolution optical coherence tomography (OCT) and computational fluid dynamics (CFD) are combined to provide quantitative analysis of the embryonic flow mechanics and the associated anatomy in a small animal model.
Department of Biomedical Engineering, National University of Singapore, Block E4 #04-08, 4 Engineering Drive 3, Singapore, 117583.
Zhen Yu Gordon
ZY
Ko
Department of Biomedical Engineering, National University of Singapore, Block E4 #04-08, 4 Engineering Drive 3, Singapore, 117583.
Kalpesh
K
Mehta
Department of Biomedical Engineering, National University of Singapore, Block E4 #04-08, 4 Engineering Drive 3, Singapore, 117583.
Muhammad
M
Jamil
Department of Biomedical Engineering, National University of Singapore, Block E4 #04-08, 4 Engineering Drive 3, Singapore, 117583.
Choon Hwai
CH
Yap
Department of Biomedical Engineering, National University of Singapore, Block E4 #04-08, 4 Engineering Drive 3, Singapore, 117583.
Nanguang
N
Chen
D000818:Animals; D001011:Aorta / Q000000981:diagnostic imaging* / Q000196:embryology / Q000502:physiology*; D002642:Chick Embryo; D003198:Computer Simulation; D004867:Equipment Design; D005240:Feasibility Studies; D006439:Hemodynamics; D057446:Hydrodynamics; D008955:Models, Cardiovascular; D012984:Software; D013314:Stress, Mechanical; D041623:Tomography, Optical Coherence / Q000295:instrumentation / Q000379:methods*
image reconstruction technique; medical and biological imaging; optical coherence tomography