Assessment of a Novel Vaccine Against Rabbit Hemorrhagic Disease Virus in Young Rabbits.
Rabbit hemorrhagic disease virus (RHDVb) is the new variant of the classical RHDV, a virulent pathogen responsible for an acute disease in young rabbits. The virus invades internal organs, especially the liver, spleen, kidneys, and gut; prevents coagulation; and causes liver necrosis. This eventually leads to quick death of the animal because of hemorrhage. In this study, we evaluated the effects of a new vaccine against RHDVb in rabbits at a young age, after experimental infection using four different viral isolates. Our findings show that the vaccine had a protective effect with survival rates reaching 80-100% against the different isolates. These results suggest that this vaccine, when applied to young animals, is an effective tool to protect against the disease caused by RHDVb in rabbitries.
1 Department of Animal Health, Faculty of Veterinary, Universidad Complutense de Madrid , Madrid, Spain .
Sonsoles
S
Pacho
1 Department of Animal Health, Faculty of Veterinary, Universidad Complutense de Madrid , Madrid, Spain .
Elias
E
Dahdouh
2 Department of Biomedical Sciences, Faculty of Veterinary, Universidad de León , León, Spain .
Javier
J
Merino
1 Department of Animal Health, Faculty of Veterinary, Universidad Complutense de Madrid , Madrid, Spain .
Monica
M
Suárez
D000818:Animals; D017250:Caliciviridae Infections / Q000401:mortality / Q000517:prevention & control* / Q000662:veterinary*; D017929:Hemorrhagic Disease Virus, Rabbit / Q000276:immunology*; D011817:Rabbits; D015996:Survival Rate; D015164:Vaccines, Inactivated / Q000008:administration & dosage / Q000276:immunology; D014765:Viral Vaccines / Q000008:administration & dosage / Q000276:immunology*
D015164:Vaccines, Inactivated; D014765:Viral Vaccines
RHDVb; disease; immunization; rabbits; vaccination