Noncoding RNA Regulation of Dopamine Signaling in Diseases of the Central Nervous System.
Dopaminergic neurotransmission mediates a majority of the vital central nervous system functions. Disruption of these synaptic events provokes a multitude of neurological pathologies, including Parkinson's, schizophrenia, depression, and addiction. Growing evidence supports a key role for noncoding RNA (ncRNA) regulation in the synapse. This review will discuss the role of both short and long ncRNAs in dopamine signaling, including bioinformatic examination of the pathways they target. Specifically, we focus on the contribution of ncRNAs to dopaminergic dysfunction in neurodegenerative as well as psychiatric disease.
Department of Chemistry, Georgia Southern University Statesboro, GA, USA.
William T
WT
Carrick
Department of Chemistry, Georgia Southern University Statesboro, GA, USA.
Brandi
B
Burks
School of Biomedical Sciences and Pharmacy and the Hunter Medical Research Institute, University of Newcastle Callaghan, NSW, Australia.
Murray J
MJ
Cairns
Department of Chemistry, Georgia Southern University Statesboro, GA, USA.
Jannet
J
Kocerha
dopamine; dopaminergic; epigenetic; microRNAs; neurodegeneration; noncoding RNA; psychiatric; schizophrenia