Oral iron absorption test with ferrous bisglycinate chelate in children with celiac disease.
BACKGROUND
Celiac disease (CD) is an immunologically-mediated enteropathy resulting in small-bowel mucosal villous atrophy with crypt hyperplasia. Iron malabsorption is usually observed in CD. Only few studies investigated oral iron absorption in subjects with gastrointestinal diseases and Iron Deficiency Anemia (IDA), using the oral iron absorption test (OIAT). We considered useful to investigate the OIAT, using ferrous bisglycinate chelate (FBC), in patients with CD at diagnosis or on gluten free diet (GFD) from at least 1 year.


METHODS
A total of 25 patients with CD (3-18 years old) and iron depletion, at diagnosis of CD (N.=12) or on GFD from at least 12 months (N.=13), were considered. Serum iron was evaluated at baseline (T0) and after 3 hours (T1) from the oral iron ingestion. Statistical analyses were conducted using SPSS 21.0 software for Mac.


RESULTS
OIAT was well tolerated by all patients. An important increase of the serum iron at T1, of at least twice the baseline values, occurred in all patients except in one (P value <0.0005).


CONCLUSIONS
These results demonstrated good efficacy of the FBC, not only in patients with CD on GFD but also in children with newly diagnosed CD with the characteristic intestinal lesions.
Unit of Pediatrics, Pugliese-Ciaccio Hospital, Magna Graecia University of Catanzaro, Catanzaro, Italy.
Giuseppe A
GA
Mazza
Unit of Pediatrics, Pugliese-Ciaccio Hospital, Magna Graecia University of Catanzaro, Catanzaro, Italy.
Santina
S
Marrazzo
Clinical Chemistry Laboratory, Pugliese-Ciaccio Hospital, Catanzaro, Italy.
Pietro
P
Gangemi
Clinical Chemistry Laboratory, Pugliese-Ciaccio Hospital, Catanzaro, Italy.
Elisabetta
E
Battaglia
Unit of Pediatrics, Pugliese-Ciaccio Hospital, Magna Graecia University of Catanzaro, Catanzaro, Italy.
Laura
L
Giancotti
Unit of Pediatrics, Pugliese-Ciaccio Hospital, Magna Graecia University of Catanzaro, Catanzaro, Italy - roberto.miniero@unicz.it.
Roberto
R
Miniero
D000284:Administration, Oral; D000293:Adolescent; D018798:Anemia, Iron-Deficiency / Q000209:etiology*; D002446:Celiac Disease / Q000150:complications / Q000178:diet therapy / Q000503:physiopathology*; D002648:Child; D002675:Child, Preschool; D055050:Diet, Gluten-Free; D005260:Female; D005296:Ferrous Compounds / Q000008:administration & dosage* / Q000493:pharmacokinetics; D005998:Glycine / Q000008:administration & dosage* / Q000493:pharmacokinetics; D006801:Humans; D008297:Male
D005296:Ferrous Compounds; C510030:ferrous bisglycinate; D005998:Glycine