Impact of disease duration and cardiovascular dysautonomia on hypertension in Parkinson's disease.
The authors evaluated the association of Parkinson's disease (PD) duration with hypertension, assessed by office measurements and 24-hour (ambulatory) monitoring, in 167 patients. Hypertension was evaluated through both office and ambulatory blood pressure (BP) measurements. Among participants (mean age 73.4±7.6 years; 35% women), the prevalence of hypertension was 60% and 69% according to office and ambulatory BP measurements, respectively (Cohen's k=0.61; P<.001). PD duration was inversely associated with hypertension as diagnosed by office measurements (odds ratio [OR], 0.92; 95% confidence interval [CI], 0.86-0.98) but not by ambulatory monitoring (OR, 0.94; 95% CI, 0.81-1.01). Ambulatory BP patterns showed higher nocturnal BP among patients with long-lasting disease. In conclusion, ambulatory BP monitoring improves the detection of hypertension by 15% in PD, compared with office evaluation. The likelihood of having hypertension does not decrease during the PD course; rather, BP pattern shifts towards nocturnal hypertension.
Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.|Department of Geriatrics, Neurosciences and Orthopaedics, Catholic University of Rome, Rome, Italy.
Davide L
DL
Vetrano
Department of Geriatrics, Neurosciences and Orthopaedics, Catholic University of Rome, Rome, Italy.
Maria S
MS
Pisciotta
Department of Geriatrics, Neurosciences and Orthopaedics, Catholic University of Rome, Rome, Italy.
Vincenzo
V
Brandi
Department of Geriatrics, Neurosciences and Orthopaedics, Catholic University of Rome, Rome, Italy.
Maria R
MR
Lo Monaco
Department of Geriatrics, Campus Bio-Medico University, Rome, Italy.
Alice
A
Laudisio
Department of Geriatrics, Neurosciences and Orthopaedics, Catholic University of Rome, Rome, Italy.
Graziano
G
Onder
Department of Geriatrics, Neurosciences and Orthopaedics, Catholic University of Rome, Rome, Italy.
Domenico
D
Fusco
Department of Cardiology, Arcispedale Santa Maria Nuova, Reggio Emilia, Italy.
Paolo D
PD
L'Angiocola
Institute of Neurology, Catholic University of Rome, Rome, Italy.|"Don Gnocchi" Foundation, Milan, Italy.
Anna R
AR
Bentivoglio
Department of Geriatrics, Neurosciences and Orthopaedics, Catholic University of Rome, Rome, Italy.
Roberto
R
Bernabei
Department of Geriatrics, Neurosciences and Orthopaedics, Catholic University of Rome, Rome, Italy.
Giuseppe
G
Zuccalà
D000368:Aged; D000369:Aged, 80 and over; D018660:Blood Pressure Monitoring, Ambulatory / Q000379:methods*; D002940:Circadian Rhythm / Q000502:physiology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000503:physiopathology; D007558:Italy / Q000453:epidemiology; D008297:Male; D010300:Parkinson Disease / Q000150:complications*; D015995:Prevalence; D054969:Primary Dysautonomias / Q000150:complications*
Parkinson′s disease; ambulatory blood pressure monitoring; dysautonomia; hypertension; non-motor symptoms