Bile Acids and the Potential Role in Primary Biliary Cirrhosis.
BACKGROUND
Bile acids (BAs) play a potential role in regulating the whole-body metabolic homeostasis via the interaction with gut microbiome and the signal transduction as messengers, which establish a link between the primary biliary cirrhosis (PBC) and gut microbiome in many aspects, particularly with regard to the immune system of the body. PBC, as a chronic cholestatic liver disease characterised by the destruction of small intrahepatic bile ducts, causes fibrosis and potential cirrhosis without efficient therapies.


CONCLUSIONS
Recent researches show BAs can induce the differentiation of hepatic stellate cells, suggesting that it may serve as a novel therapy to resist, even changeover the irreversible liver cirrhosis in PBC. Key Messages: In this review, we conclude and provide information on the possible mechanism of pleiotropic BAs in homeostasis of the gut microbiome and liver regeneration, and hope to broaden the therapy of PBC and promote the relevant drugs' development.
The Second Department of Gastroenterology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
Hang
H
Yang
Zhijun
Z
Duan
D001647:Bile Acids and Salts / Q000378:metabolism*; D001653:Bile Ducts, Intrahepatic / Q000473:pathology; D002790:Cholesterol 7-alpha-Hydroxylase / Q000378:metabolism; D000069196:Gastrointestinal Microbiome / Q000276:immunology*; D055166:Hepatic Stellate Cells / Q000502:physiology; D022781:Hepatocytes / Q000378:metabolism; D006801:Humans; D008099:Liver / Q000502:physiology*; D008105:Liver Cirrhosis, Biliary / Q000276:immunology* / Q000378:metabolism*; D012038:Regeneration; D015398:Signal Transduction; D013253:Steroid 12-alpha-Hydroxylase / Q000378:metabolism; D051178:alpha Catenin / Q000378:metabolism
D001647:Bile Acids and Salts; D051178:alpha Catenin; C553219:CYP7A1 protein, human; D002790:Cholesterol 7-alpha-Hydroxylase; D013253:Steroid 12-alpha-Hydroxylase