Effects of Low-Level Laser Therapy in Orthodontic Patients on Immediate Inflammatory Response After Mini-Implants Insertion: A Preliminary Report.
BACKGROUND
The primary stability of a mini-implant is crucial to treatment sequence since most orthodontic mini-implant failures occur at an early stage. Irritation or inflammation of peri-implant tissues has been related to decreasing mini-implant success.


OBJECTIVE
This study evaluates the effect of low-level laser therapy on initial inflammation after orthodontic mini-implants installation.


METHODS
Ten volunteers received two mini-implants (1.3 mm diameter, 7 mm length). One mini-implant was inserted on each side of the maxilla following manufacturer recommendation. On the right side, low-level laser therapy (LLLT) was applied (diode laser 660 nm, 40 mW, 1 min, 2.4 J of total energy). Peri-implant crevicular fluid (PGF) was obtained after 24 h (T1), 48 h (T2), and 72 h (T3) to identify levels of interleukin (IL)-6 and IL-8 around mini-implants and around upper first premolars.


RESULTS
An increase in interleukin levels was observed for both groups, compared to upper first premolar. PGF around nonirradiated mini-implants showed higher levels of IL-8. Levels of IL-6 24 h after mini-implant insertion were higher for laser group.


CONCLUSIONS
LLLT modulates the initial inflammation after the insertion of mini-implant, possibly increasing the mini-implant success prognostic and decreasing patient discomfort.
São Leopoldo Mandic Dental Research Center , Rua José Rocha Junqueira, 13, Campinas, Brazil .
Mario S
MS
Yanaguizawa
São Leopoldo Mandic Dental Research Center , Rua José Rocha Junqueira, 13, Campinas, Brazil .
Selly S
SS
Suzuki
São Leopoldo Mandic Dental Research Center , Rua José Rocha Junqueira, 13, Campinas, Brazil .
Elizabeth F
EF
Martinez
São Leopoldo Mandic Dental Research Center , Rua José Rocha Junqueira, 13, Campinas, Brazil .
Hideo
H
Suzuki
São Leopoldo Mandic Dental Research Center , Rua José Rocha Junqueira, 13, Campinas, Brazil .
Maria Cristina J
MC
Pelegrin
São Leopoldo Mandic Dental Research Center , Rua José Rocha Junqueira, 13, Campinas, Brazil .
Aguinaldo S
AS
Garcez
D000328:Adult; D015921:Dental Implants; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000032:analysis; D016209:Interleukin-8 / Q000032:analysis; D028022:Low-Level Light Therapy; D008297:Male
D015921:Dental Implants; D015850:Interleukin-6; D016209:Interleukin-8
inflammation; interleukin; laser therapy; miniscrew; orthodontic anchorage