Development and Validation of an Algorithm to Identify Patients with Multiple Myeloma Using Administrative Claims Data.
OBJECTIVE
The objective was to expand on prior work by developing and validating a new algorithm to identify multiple myeloma (MM) patients in administrative claims.


METHODS
Two files were constructed to select MMcasesfrom MarketScan Oncology Electronic Medical Records (EMR) andcontrolsfrom the MarketScan Primary Care EMR during January 1, 2000-March 31, 2014. Patients were linked to MarketScan claims databases, and files were merged. Eligible cases were age ≥18, had a diagnosis and visit for MM in the Oncology EMR, and were continuously enrolled in claims for ≥90 days preceding and ≥30 days after diagnosis. Controls were age ≥18, had ≥12 months of overlap in claims enrollment (observation period) in the Primary Care EMR and ≥1 claim with an ICD-9-CM diagnosis code of MM (203.0×) during that time. Controls were excluded if they had chemotherapy; stem cell transplant; or text documentation of MM in the EMR during the observation period. A split sample was used to develop and validate algorithms. A maximum of 180 days prior to and following each MM diagnosis was used to identify events in the diagnostic process. Of 20 algorithms explored, the baseline algorithm of 2 MM diagnoses and the 3 best performing were validated. Values for sensitivity, specificity, and positive predictive value (PPV) were calculated.


CONCLUSIONS
Three claims-based algorithms were validated with ~10% improvement in PPV (87-94%) over prior work (81%) and the baseline algorithm (76%) and can be considered for future research. Consistent with prior work, it was found that MM diagnoses before and after tests were needed.
Truven Health , Cambridge, MA , USA.
Nicole
N
Princic
Truven Health , Cambridge, MA , USA.
Chris
C
Gregory
Truven Health , Cambridge, MA , USA.
Tina
T
Willson
Onyx Pharmaceuticals Inc., An Amgen Subsidiary , San Francisco, CA , USA.
Maya
M
Mahue
Onyx Pharmaceuticals Inc., An Amgen Subsidiary , San Francisco, CA , USA.
Diana
D
Felici
Onyx Pharmaceuticals Inc., An Amgen Subsidiary , San Francisco, CA , USA.
Winifred
W
Werther
Truven Health , Cambridge, MA , USA.
Gregory
G
Lenhart
Truven Health , Cambridge, MA , USA.
Kathleen A
KA
Foley
administrative claims; algorithm; electronic medical records; multiple myeloma