Potential use of nanocarriers with pentacyclic triterpenes in cancer treatments.
Ursolic, oleanolic and betulinic acids are representative pentacyclic triterpenoids found in various plants and fruits. Despite having marked antitumor potentials, the very poor water solubility of these triterpenes hinders treatment development. Nanotechnology can enhance solubility, stability, bioavailability and phytochemical delivery, improving the therapeutic efficiency of triterpenes. This review focuses on the formulation, characterization and in vitro/in vivo evaluation of several delivery nanosystems used to enhance the physicochemical properties of ursolic, oleanolic and betulinic acids.
Departamento de Ciencias y Tecnología Farmacéutica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago, Chile.
Karina
K
Valdés
Departamento de Ciencias y Tecnología Farmacéutica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago, Chile.
Javier
J
Morales
Facultad de Farmacia y Bioquímica, Universidad Nacional de Trujillo, Trujillo, Perú.
Lennin
L
Rodríguez
Departamento de Química Orgánica y Fisicoquímica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago, Chile.
Germán
G
Günther
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000627:therapeutic use; D001682:Biological Availability; D016503:Drug Delivery Systems; D065546:Drug Liberation; D006801:Humans; D053769:Nanocapsules / Q000737:chemistry*; D009369:Neoplasms / Q000188:drug therapy*; D009828:Oleanolic Acid / Q000737:chemistry; D053978:Pentacyclic Triterpenes / Q000008:administration & dosage* / Q000737:chemistry / Q000627:therapeutic use; D012995:Solubility; D014315:Triterpenes / Q000737:chemistry; D053835:Unilamellar Liposomes / Q000737:chemistry; D014867:Water; D000094062:Betulinic Acid; D000097245:Ursolic Acid
D000970:Antineoplastic Agents; D053769:Nanocapsules; D009828:Oleanolic Acid; D053978:Pentacyclic Triterpenes; D014315:Triterpenes; D053835:Unilamellar Liposomes; D014867:Water; D000094062:Betulinic Acid; D000097245:Ursolic Acid
antitumoral; betulinic acid; liposomes; nanocarriers; nanoemulsion; nanoparticles; nanosystems; nanotechnology; oleanolic acid; ursolic acid