Membranoproliferative Glomerulonephritis Secondary to a Low-Grade Lymphoproliferative Disorder: A Rare Cause of Renal Dysfunction.
Chronic lymphocytic leukemia is a B-cell neoplasm with an indolent clinical course. Most patients are asymptomatic and are diagnosed incidentally on a routine blood count. The malignant cells of this low-grade neoplasm infiltrate various organs and tissues. However, the resultant end organ damage is a rare phenomenon. Here we describe a case of chronic lymphocytic leukemia that presented with an unusual cause of acute renal dysfunction. The patient had deranged renal parameters with a nephrotic range proteinuria. The uncommon cause for his renal problem was membranoproliferative glomerulonephritis diagnosed by performing a kidney biopsy. Moreover, the acute renal dysfunction in this patient mandated an appropriate treatment and as of now there are no well-established treatment protocols for chronic lymphocytic leukemia with nephrotic syndrome. The patient was successfully treated with rituximab and bendamustine based on the expertise and judgement of the clinician.
Department of Hematology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Tushar
T
Sehgal
Department of Hematology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Nidhi
N
Jain
Department of Hematology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Gaurav
G
Prakash
Department of Histopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Ritambhra
R
Duseja
Department of Hematology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Neelam
N
Varma
Chronic lymphocytic leukemia; Membranoproliferative glomerulonephritis; Renal dysfunction; Treatment