Prognostic Significance of High VEGF-C Expression for Patients with Breast Cancer: An Update Meta Analysis.
BACKGROUND
The prognostic significance of vascular endothelial growth factor C (VEGF-C) expression in breast cancer (BC) patients remains controversial. Therefore, this meta-analysis was performed to determine the prognostic significance of VEGF-C expression in BC patients.


METHODS
Several electronic databases were searched from January 1991 to August 2016. The pooled hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated to evaluate the prognostic significance of VEGF-C expression for disease free survival (DFS) and overall survival (OS).


RESULTS
The present meta analysis totally included 21 eligible studies and 2828 patients with BC. The combined HRs were 1.87(95% CI 1.25-2.79, P = 0.001) for DFS and 1.96(95% CI 1.15-3.31, P = 0.001) for OS. The pooled HRs of non-Asian subgroup were 2.04(95%CI 1.36-3.05, P = 0.001) for DFS and 2.61(95%CI 1.51-4.52, P = 0.001) for OS, which were significantly higher than that of Asian subgroup. The funnel plot for publication bias was symmetrical. The further Egger's test and Begg's test did not detect significant publication bias (all P>0.05).


CONCLUSIONS
The present meta analysis strongly supported the prognostic role of VEGF-C expression for DFS and OS in BC patients, especially for patients in non-Asian countries. Furthermore, stratification by VEGF-C expression may help to optimize the treatments and the integrated managements for BC patients.
Department of Infectious Disease, The First People's Hospital of Shunde, Shunde, Guangdong, China.
Zhiqiao
http://orcid.org/0000-0003-4631-8818
Z
Zhang
Department of Internal Medicine, The Chencun Affiliated Hospital of First People's Hospital of Shunde, Shunde, Guangdong, China.
Guanying
G
Luo
Department of Science and Education, The First People's Hospital of Shunde, Shunde, Guangdong, China.
Hongfeng
H
Tang
Department of Internal Medicine, The Chencun Affiliated Hospital of First People's Hospital of Shunde, Shunde, Guangdong, China.
Canchang
C
Cheng
Department of Infectious Disease, The First People's Hospital of Shunde, Shunde, Guangdong, China.
Peng
P
Wang
D014408:Biomarkers, Tumor / Q000378:metabolism*; D001943:Breast Neoplasms / Q000401:mortality* / Q000473:pathology*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D016016:Proportional Hazards Models; D042582:Vascular Endothelial Growth Factor C / Q000378:metabolism*
D014408:Biomarkers, Tumor; D042582:Vascular Endothelial Growth Factor C