Elevated preoperative plasma fibrinogen level is an independent predictor of malignancy and advanced stage disease in patients with bladder urothelial tumors.
OBJECTIVE
To investigate the association between preoperative plasma fibrinogen levels and clinicopathological features in patients with bladder urothelial tumors.


METHODS
In this retrospective single-center study, we evaluated preoperative plasma fibrinogen levels in 503 patients newly diagnosed with bladder urothelial tumors between January 2009 and October 2014. All patients received surgical intervention as the primary treatment method. Associations between preoperative plasma fibrinogen levels and clinicopathological parameters were analyzed. Univariate and multivariate logistic regression analyses were performed to identify independent associations.


RESULTS
The mean preoperative fibrinogen level in patients with bladder urothelial carcinoma (BUC) was significantly higher than that in patients with papilloma or papillary urothelial neoplasm of low malignant potential (PUNLMP) (P = 0.004). Additionally, patients with BUC with advanced-stage disease showed elevated plasma fibrinogen levels compared to patients with early-stage disease (high-grade BUC vs. low-grade BUC: P = 0.002; muscle-invasive BUC vs. non-muscle-invasive BUC: P = 0.010). In a multivariate regression model, a plasma fibrinogen level >3.04 g/L was identified to be independently associated with the presence of BUC (hazard ratio [HR] = 1.653, P = 0.047), high-grade BUC (HR = 1.869, P = 0.004), and muscle-invasive BUC (HR = 1.870, P = 0.044).


CONCLUSIONS
Elevated preoperative plasma fibrinogen level is an independent predictor of malignancy as well as advanced-stage carcinoma in patients with bladder urothelial tumors, suggesting that plasma fibrinogen may be a promising diagnostic and prognostic biomarker for bladder tumors.
Department of Urology, Jinshan Hospital of Fudan University, Shanghai City, 201508, PR China.
Jikai
J
Liu
Department of Urology, Qilu Hospital of Shandong University, Jinan City, Shandong Province, 250012, PR China.
Dawei
D
Li
Department of Urology, Qilu Hospital of Shandong University, Jinan City, Shandong Province, 250012, PR China.
Li
L
Cao
Department of Urology, Jinshan Hospital of Fudan University, Shanghai City, 201508, PR China.
Zhanyu
Z
Wang
Department of Urology, Qilu Hospital of Shandong University, Jinan City, Shandong Province, 250012, PR China.
Yan
Y
Li
Department of Urology, Qilu Hospital of Shandong University, Jinan City, Shandong Province, 250012, PR China.
Hainan
H
Liu
Department of Urology, Jinshan Hospital of Fudan University, Shanghai City, 201508, PR China. Electronic address: chengang305@163.com.
Gang
G
Chen
D000328:Adult; D000368:Aged; D005260:Female; D005340:Fibrinogen / Q000032:analysis*; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D001749:Urinary Bladder Neoplasms / Q000097:blood* / Q000473:pathology / Q000601:surgery
D005340:Fibrinogen
Bladder urothelial tumor; Clinicopathological feature; Plasma fibrinogen