MITO-Porter for Mitochondrial Delivery and Mitochondrial Functional Analysis.
Mitochondria are attractive organelles that have the potential to contribute greatly to medical therapy, the maintenance of beauty and health, and the development of the life sciences. Therefore, it would be expected that the further development of mitochondrial drug delivery systems (DDSs) would exert a significant impact on the medical and life sciences. To achieve such an innovative objective, it will be necessary to deliver various cargoes to mitochondria in living cells. However, only a limited number of approaches are available for accomplishing this. We recently proposed a new concept for mitochondrial delivery, a MITO-Porter, a liposome-based carrier that introduces macromolecular cargoes into mitochondria via membrane fusion. To date, we have demonstrated the utility of mitochondrial therapeutic strategy by MITO-Porter using animal models of diseases. We also showed that the mitochondrial delivery of antisense oligo-RNA by the MITO-Porter results in mitochondrial RNA knockdown and has a functional impact on mitochondria. Here, we summarize the current state of mitochondrial DDS focusing on our research and show some examples of mitochondrial functional regulations using mitochondrial DDS.
Laboratory for Molecular Design of Pharmaceutics, Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo, 060-0812, Japan.
Yuma
Y
Yamada
Laboratory for Molecular Design of Pharmaceutics, Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo, 060-0812, Japan. harasima@pharm.hokudai.ac.jp.
Hideyoshi
H
Harashima
D000818:Animals; D004195:Disease Models, Animal; D016503:Drug Delivery Systems; D020868:Gene Silencing; D015316:Genetic Therapy; D006801:Humans; D008081:Liposomes; D008561:Membrane Fusion; D008928:Mitochondria / Q000502:physiology*
D008081:Liposomes
MITO-Porter; Membrane fusion; Mitochondria; Mitochondrial drug delivery; Mitochondrial function; Mitochondrial gene therapy; Mitochondrial medicine development