A comparative analysis of angiopoietin 2 immunohistochemical staining in various stages of lung cancer.
OBJECTIVE
The role of Angiopoietin 2 (Ang 2), which is necessary for tumor growth, extension, and metastasis is not fully elucidated. The presented study aimed to investigate the relationship between Ang 2 staining intensity, expression rate in tumor tissue, and the stage of lung cancer.


METHODS
Fifty cases of lung cancer (34 non-small and 16 small cell cases) were included in the study. Immunohistochemistry was done to evaluate Ang 2 staining intensity and expression rate in tumor and stromal cells of lung cancer tissue.


RESULTS
Ang 2 was positive for 45 (90%) cases and negative for five (10%) cases (P = 0.04). There was a significant correlation between Ang 2 expression rate of expression and the histologic type of lung cancer (P = 0.033). Ang 2 expression rate in tumor cells of cancer tissues diagnosed with adenocarcinoma was low. There was a significant correlation between Ang 2 expression rate in stromal cells of cancer tissue and the type of lung cancer (P = 0.021). Stromal cell expression rate of Ang 2 in adenocarcinoma was found to be low.


CONCLUSIONS
As a result, the relationship between lung cancer stage and Ang 2 was documented with this study and the expression rate was found to be lower in adenocarcinomas. By this analysis, we can suggest that angiopoietins may be used as an option for targeted treatment in lung cancer.
Department of Thoracic Medicine, Gumussuyu Military Hospital, Istanbul, Turkey.
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Oztutgan
Department of Thoracic Medicine, GATA Haydarpasa Training Hospital, Istanbul, Turkey.
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Demirer
Department of Thoracic Medicine, GATA Haydarpasa Training Hospital, Istanbul, Turkey.
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Tas
Department of Thoracic Medicine, Yedikule Chest Disease Hospital, Istanbul, Turkey.
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A
Uysal
Department of Thoracic Medicine, GATA Haydarpasa Training Hospital, Istanbul, Turkey.
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Caliskan
Department of Pathology, GATA Haydarpasa Training Hospital, Istanbul, Turkey.
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Kucukodaci
Department of Thoracic Medicine, GATA Haydarpasa Training Hospital, Istanbul, Turkey.
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Ayten
Department of Thoracic Medicine, GATA Haydarpasa Training Hospital, Istanbul, Turkey.
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O
Okutan
Department of Thoracic Medicine, GATA Haydarpasa Training Hospital, Istanbul, Turkey.
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Z
Kartaloglu
D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology; D000368:Aged; D042702:Angiopoietin-2 / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000032:analysis; D002289:Carcinoma, Non-Small-Cell Lung / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000378:metabolism* / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009389:Neovascularization, Pathologic; D055752:Small Cell Lung Carcinoma / Q000378:metabolism / Q000473:pathology; D013194:Staining and Labeling; D042461:Vascular Endothelial Growth Factor A / Q000032:analysis*
C586513:ANGPT2 protein, human; D042702:Angiopoietin-2; D014408:Biomarkers, Tumor; D042461:Vascular Endothelial Growth Factor A