Per(3-chloro-4-methyl)phenylcarbamate cyclodextrin clicked stationary phase for chiral separation in multiple modes high-performance liquid chromatography.
In this work, a detail study has been performed on the enantioselectivity of per(3-chloro-4-methyl)phenylcarbamate-β-CD clicked chiral stationary phase (CSP) in high-performance liquid chromatography. Both normal phase and polar organic mobile phases have been explored for the enantioseparation of 39 model racemic pairs including aromatic alcohols, flavonoids, β-blockers and amino acids. Chiral resolution values over 10 were achieved for flavonoids. The comparison study with reference perphenylcarbamate-β-CD clicked CSP reveals the significance of 3-chloro-4-methyl functionality in improving the enantioselectivities. This study may provide insight on the multiple interactions between functionalized CD and analytes.
College of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, People's Republic of China.
Jian
J
Tang
College of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, People's Republic of China.
Limin
L
Pang
College of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, People's Republic of China.
Jie
J
Zhou
College of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, People's Republic of China.
Shaopeng
S
Zhang
College of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, People's Republic of China. Electronic address: whtang@mail.njust.edu.cn.
Weihua
W
Tang
Chiral stationary phase; Cyclodextrin; Enantioselectivity; High-performance liquid chromatography