Direct Catalytic Hydrogenation of Simple Amides: A Highly Efficient Approach from Amides to Amines and Alcohols.
A highly chemoselective and reactive direct catalytic reduction of various amides to amines and alcohols was developed by using a tetradentate ruthenium complex. The catalytic system showed excellent activity (turnover numbers up to 19 600) and great functional group tolerance under mild reaction conditions, compared to several bidentate and tridentate ruthenium-catalyzed systems.
College of Chemistry and Molecular Sciences, Wuhan University, 430072, Wuhan, P. R. China.
Liyang
L
Shi
College of Chemistry and Molecular Sciences, Wuhan University, 430072, Wuhan, P. R. China.
Xuefeng
X
Tan
College of Chemistry and Molecular Sciences, Wuhan University, 430072, Wuhan, P. R. China.
Jiao
J
Long
College of Chemistry and Molecular Sciences, Wuhan University, 430072, Wuhan, P. R. China.
Xiong
X
Xiong
College of Chemistry and Molecular Sciences, Wuhan University, 430072, Wuhan, P. R. China.
Song
S
Yang
College of Chemistry and Molecular Sciences, Wuhan University, 430072, Wuhan, P. R. China.
Peng
P
Xue
College of Chemistry and Molecular Sciences, Wuhan University, 430072, Wuhan, P. R. China.|Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, 100190, Beijing, P. R. China.
Hui
H
Lv
College of Chemistry and Molecular Sciences, Wuhan University, 430072, Wuhan, P. R. China.
Xumu
X
Zhang
alcohols; amides; amines; chemoselectivity; hydrogenation