Relationship of HLA-B*51 and HLA-B*52 alleles and TNF-α-308A/G polymorphism with susceptibility to Takayasu arteritis: a meta-analysis.
We performed a meta-analysis to determine whether combined evidence shows an association between HLA-B*51 and HLA-B*52 alleles and TNF-α-308A/G polymorphism and the susceptibility to Takayasu arteritis (TA). Relevant articles dated November 2015 were acquired from the PubMed, Embase and Cochrane databases. The number of genotypes and/or alleles for HLA-B*51 and HLA-B*52 alleles and TNF-α-308 A/G polymorphism in cases and control subjects was extracted, and statistical analysis was conducted using STATA 11.2 software. We included 20 studies with 1864 TA patients and 6973 controls. The HLA-B*52 allele was found to be associated with TA (pooled OR 3.91, 95 % CI 3.22-4.74, P < 0.0001). The meta-analysis of TNF-α-308 A/G polymorphism for the A allele vs. G allele (P = 0.006) and AA + AG vs. GG (P = 0.023) revealed a significant association with TA. However, we did not find that the HLA-B*51 allele was associated with TA. This meta-analysis demonstrated that the HLA-B*52 allele and TNF-α-308 A/G polymorphism may contribute to TA susceptibility.
Department of Clinical Laboratory, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Si
S
Chen
Department of Clinical Laboratory, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Haixia
H
Luan
Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China.
Liubing
L
Li
Department of Clinical Laboratory, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Xiaoli
X
Zeng
Department of Clinical Laboratory, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Tian
T
Wang
Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China. yongzhelipumch@126.com.
Yongzhe
Y
Li
Department of Clinical Laboratory, Beijing Anzhen Hospital, Capital Medical University, Beijing, China. 18911662931@189.cn.
Hui
H
Yuan
D000483:Alleles; D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D059949:HLA-B51 Antigen / Q000235:genetics*; D059950:HLA-B52 Antigen / Q000235:genetics*; D006801:Humans; D007249:Inflammation; D011110:Polymorphism, Genetic; D012680:Sensitivity and Specificity; D013625:Takayasu Arteritis / Q000235:genetics*; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
D059949:HLA-B51 Antigen; D059950:HLA-B52 Antigen; C439524:TNF protein, human; D014409:Tumor Necrosis Factor-alpha
HLA; Meta-analysis; Polymorphism; TNF-α; Takayasu arteritis