Estimating Catabolism: A Possible Tool for Nutritional Monitoring of Patients With Acute Kidney Injury.
Hypercatabolism has been described as the main nutritional change in acute kidney injury. Catabolism may be defined as the excessive release of amino acids from skeletal muscle. Conditions such as fasting, inadequate nutritional support, renal replacement therapy, metabolic acidosis, and secretion of catabolic hormones are the main factors that affect protein catabolism. Given the imprecision of the methods conventionally used to assess and monitor the nutritional status of hospitalized patients, the parameters of protein catabolism, such as nitrogen balance, urea nitrogen appearance, and protein catabolic rate appear to be the main measures in this population. Considering the high prevalence of malnutrition in this population and important limitations in this clinical condition, such as the inflammatory state and altered fluid, catabolism parameters are accurate and reliable methods that could contribute to minimize adverse prognosis in this population.
Department of Internal Medicine, Botucatu Medical School-UNESP, São Paulo State University, São Paulo, Brazil. Electronic address: mnberbel@yahoo.com.br.
Marina Nogueira Berbel
MN
Bufarah
Department of Internal Medicine, Botucatu Medical School-UNESP, São Paulo State University, São Paulo, Brazil.
Cassiana Regina
CR
de Góes
Department of Internal Medicine, Botucatu Medical School-UNESP, São Paulo State University, São Paulo, Brazil.
Mariana
M
Cassani de Oliveira
Department of Internal Medicine, Botucatu Medical School-UNESP, São Paulo State University, São Paulo, Brazil.
Daniela
D
Ponce
Department of Internal Medicine, Botucatu Medical School-UNESP, São Paulo State University, São Paulo, Brazil.
André Luis
AL
Balbi
D058186:Acute Kidney Injury / Q000175:diagnosis*; D001806:Blood Urea Nitrogen; D015992:Body Mass Index; D006801:Humans; D044342:Malnutrition / Q000175:diagnosis*; D015596:Nutrition Assessment; D009752:Nutritional Status; D018529:Nutritional Support; D015995:Prevalence; D011506:Proteins / Q000378:metabolism*; D017582:Renal Replacement Therapy
D011506:Proteins