MiRNAs and miRNA Polymorphisms Modify Drug Response.
Differences in expression of drug response-related genes contribute to inter-individual variation in drugs' biological effects. MicroRNAs (miRNAs) are small noncoding RNAs emerging as new players in epigenetic regulation of gene expression at post-transcriptional level. MiRNAs regulate the expression of genes involved in drug metabolism, drug transportation, drug targets and downstream signal molecules directly or indirectly. MiRNA polymorphisms, the genetic variations affecting miRNA expression and/or miRNA-mRNA interaction, provide a new insight into the understanding of inter-individual difference in drug response. Here, we provide an overview of the recent progress in miRNAs mediated regulation of biotransformation enzymes, drug transporters, and nuclear receptors. We also describe the implications of miRNA polymorphisms in cancer chemotherapy response.
Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China. elskesunny@163.com.|Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University, Changsha 410078, China. elskesunny@163.com.
Mu-Peng
MP
Li
Department of Cardiology, Heping Hospital Affiliated to Changzhi Medical College, Changzhi 046000, China. leexz2010@163.com.
Yao-Dong
YD
Hu
Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China. huxiaolei66@126.com.|Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University, Changsha 410078, China. huxiaolei66@126.com.
Xiao-Lei
XL
Hu
Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China. zhangyj287112687@163.com.|Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University, Changsha 410078, China. zhangyj287112687@163.com.
Yan-Jiao
YJ
Zhang
Haikou People's Hospital and Affiliated Haikou Hospital of Xiangya Medical School, Central South University, Haikou 570311, China. yyl0756@yeah.net.
Yong-Long
YL
Yang
Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China. JChun213@163.com.|Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University, Changsha 410078, China. JChun213@163.com.
Chun
C
Jiang
Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China. chenxp74@hotmail.com.|Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University, Changsha 410078, China. chenxp74@hotmail.com.
Jie
J
Tang
Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China. jietang@csu.edu.cn.|Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University, Changsha 410078, China. jietang@csu.edu.cn.
Xiao-Ping
XP
Chen
D001692:Biological Transport; D006801:Humans; D008658:Inactivation, Metabolic; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D011110:Polymorphism, Genetic; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics*
D035683:MicroRNAs; D018160:Receptors, Cytoplasmic and Nuclear
drug response; miRNA polymorphisms; microRNA; prognosis