Guidelines to improve animal study design and reproducibility for Alzheimer's disease and related dementias: For funders and researchers.
The reproducibility of laboratory experiments is fundamental to the scientific process. There have been increasing reports regarding challenges in reproducing and translating preclinical experiments in animal models. In Alzheimer's disease and related dementias, there have been similar reports and growing interest from funding organizations, researchers, and the broader scientific community to set parameters around experimental design, statistical power, and reporting requirements. A number of efforts in recent years have attempted to develop standard guidelines; however, these have not yet been widely implemented by researchers or by funding agencies. A workgroup of the International Alzheimer's disease Research Funder Consortium, a group of over 30 research funding agencies from around the world, worked to compile the best practices identified in these prior efforts for preclinical biomedical research. This article represents a consensus of this work group's review and includes recommendations for researchers and funding agencies on designing, performing, reviewing, and funding preclinical research studies.
Division of Medical & Scientific Relations, Alzheimer's Association, Chicago, IL, USA. Electronic address: hsnyder@alz.org.
Heather M
HM
Snyder
Scientific Affairs, Alzheimer's Drug Discovery Foundation, New York, NY, USA.
Diana W
DW
Shineman
Scientific Affairs, Alzheimer's Drug Discovery Foundation, New York, NY, USA.
Lauren G
LG
Friedman
Division of Medical & Scientific Relations, Alzheimer's Association, Chicago, IL, USA.
James A
JA
Hendrix
Editorial Office, Alzheimer's & Dementia: The Journal of the Alzheimer's Association, Washington, DC, USA.
Ara
A
Khachaturian
Research Division, Alzheimer's Society, London, UK.
Ian
I
Le Guillou
Research Division, Alzheimer's Society, London, UK.
James
J
Pickett
Division of Neuroscience, National Institute on Aging at the National Institutes of Health, Bethesda, MD, USA.
Lorenzo
L
Refolo
Research Division, Alzheimer's Research UK, Cambridge, UK.
Rosa M
RM
Sancho
Research Division, Alzheimer's Research UK, Cambridge, UK.
Simon H
SH
Ridley
D000818:Animals; D003704:Dementia; D004195:Disease Models, Animal; D015203:Reproducibility of Results; D012107:Research Design
Alzheimer's disease; Animal models; Drug development; Preclinical; Reproducibility