Hyperuricemia is an independent risk factor for  renal pathological damage and poor prognosis in  lupus nephritis patients.
To explore the correlation between hyperuricemia and renal damage in patients with lupus nephritis (LN).  Methods: The data for clinical features, laboratory and renal pathological examination were collected from 177 renal biopsy-proven LN patients with or without hyperuricemia and were retrospectively analyzed to determine the correlation between serum uric acid and renal damage.  Results: LN patients with hyperuricemia group had higher rate of hypertension and higher level of blood urea nitrogen and serum creatinine while lower estimated glomerular filtration rate (eGFR) and lower positive rate of anti-U1RNP antibody (P<0.05). In the LN patients with hyperuricemia group, renal pathological scores, including acitive index, chronic index and tubulointerstitial lesions, were higher than those in the LN patients without hyperuricemia group (P<0.05). The level of serum uric acid was positively correlated with serum creatinine, renal pathological classification and renal pathological scores while negatively correlated with eGFR (P<0.05).  Conclusion: LN patients with hyperuricemia are associated with more serious renal damage. Hyperuricemia is an important predictor for poor prognosis in patients with LN.
Department of Rheumatology, Xiangya Hospital, Central South University, Changsha 410008, China.
Tingting
T
Xie
Department of Rheumatology, Xiangya Hospital, Central South University, Changsha 410008, China.
Mengying
M
Chen
Department of Rheumatology, Xiangya Hospital, Central South University, Changsha 410008, China.
Xiangling
X
Tang
Department of Pathology,  Xiangya Hospital, Central South University, Changsha 410008, China.
Hongling
H
Yin
Department of Rheumatology, Xiangya Hospital, Central South University, Changsha 410008, China.
Xuan
X
Wang
School of Life Sciences, Central South University, Changsha 410013, China.
Guoli
G
Li
Department of Rheumatology, Xiangya Hospital, Central South University, Changsha 410008, China.
Jiarong
J
Li
Department of Rheumatology, Xiangya Hospital, Central South University, Changsha 410008, China.
Xiaoxia
X
Zuo
Department of Rheumatology, Xiangya Hospital, Central South University, Changsha 410008, China.
Weiru
W
Zhang
D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000097:blood; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology; D006801:Humans; D006973:Hypertension; D006977:Hypertension, Renal; D033461:Hyperuricemia / Q000453:epidemiology*; D007668:Kidney / Q000473:pathology*; D008181:Lupus Nephritis / Q000150:complications* / Q000175:diagnosis; D008297:Male; D011379:Prognosis; D012189:Retrospective Studies; D017412:Ribonucleoprotein, U1 Small Nuclear / Q000097:blood; D012307:Risk Factors; D014527:Uric Acid / Q000097:blood
D017412:Ribonucleoprotein, U1 Small Nuclear; D014527:Uric Acid; D003404:Creatinine