Epidemiological and etiological investigation of dengue fever in the Fujian province of China during 2004-2014.
Dengue fever (DF) is a vector-borne disease and a tremendous socioeconomic burden on tropical and subtropical countries worldwide. To explore the characteristics of DF epidemic in the Fujian province, information of DF cases in Fujian during 2004-2014 was collected and analyzed. The complete E genes of 48 viral isolates were amplified and sequenced for phylogenetic analysis. A total of 733 cases was reported, of which 612 (83.5%) occurred during the peak period from August to October. Additionally, 76% (190/250) of imported cases originated from Southeast Asia countries, by the epidemiological investigation. Phylogenetic analysis of the 48 viral isolates revealed that three genotypes (I, IV, V) of DENV1, and one genotype each of DENV2 (cosmopolitan) and DENV3 (I) circulated in Fujian during 2004-2014. Similar to the results of the epidemiological investigations, the source of most of the viral isolates, including imported and indigenous cases, may be Southeast Asia countries; however, importation from adjacent provinces was also observed in recent years. Overall, DF is considered an imported epidemic disease in Fujian. Increasing diversity of the viral source and geographic expansion of the area affected by DF in recent years highlights the necessity for strengthening surveillance of the DF epidemic and developing strategies for DF prevention and control in Fujian.
Fujian Center for Disease Control and Prevention, Fuzhou, 350001, China.
Jinzhang
J
Wang
Fujian Center for Disease Control and Prevention, Fuzhou, 350001, China.
Hongbing
H
Chen
Fujian Center for Disease Control and Prevention, Fuzhou, 350001, China.
Meng
M
Huang
Fujian Center for Disease Control and Prevention, Fuzhou, 350001, China.
Yongjun
Y
Zhang
Fujian Center for Disease Control and Prevention, Fuzhou, 350001, China.
Jianfeng
J
Xie
Fujian Center for Disease Control and Prevention, Fuzhou, 350001, China.|College of public health, Fujian Medicine University, Fuzhou, 350001, China.
Yansheng
Y
Yan
Fujian Center for Disease Control and Prevention, Fuzhou, 350001, China.|College of public health, Fujian Medicine University, Fuzhou, 350001, China.
Kuicheng
K
Zheng
Fujian Center for Disease Control and Prevention, Fuzhou, 350001, China. wengywfjcdc@aliyun.com.|College of public health, Fujian Medicine University, Fuzhou, 350001, China. wengywfjcdc@aliyun.com.
Yuwei
Y
Weng
D001210:Asia, Southeastern / Q000208:ethnology; D044466:Asian People; D002681:China / Q000453:epidemiology; D018076:DNA, Complementary / Q000737:chemistry / Q000235:genetics; D003715:Dengue / Q000453:epidemiology* / Q000208:ethnology / Q000821:virology; D003716:Dengue Virus / Q000145:classification / Q000235:genetics* / Q000502:physiology; D004196:Disease Outbreaks; D014644:Genetic Variation; D005838:Genotype; D054884:Host-Pathogen Interactions; D006801:Humans; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics / Q000302:isolation & purification; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012621:Seasons; D017422:Sequence Analysis, DNA; D014759:Viral Envelope Proteins / Q000145:classification / Q000235:genetics / Q000502:physiology
D018076:DNA, Complementary; D012367:RNA, Viral; D014759:Viral Envelope Proteins; C072281:E protein TH Sman, Dengue virus
E gene; dengue virus; epidemiology; etiology; phylogenetic tree