Alcohol use and hepatitis C virus treatment outcomes among patients receiving direct antiviral agents.
It is unclear whether alcohol use negatively impacts HCV treatment outcomes in the era of direct antiviral agents (DAAs). We aimed to evaluate the associations between current levels of drinking and treatment response among persons treated for HCV with DAAs in the national Veterans Affairs (VA) healthcare system.



We identified patients who initiated HCV DAAs over 18 months (1/1/14-6/30/15) and had documented alcohol screening with the Alcohol Use Disorders Identification Test Consumption (AUDIT-C) questionnaire within one year prior to initiating therapy. DAAs included: sofosbuvir (SOF), ledipasvir/sofosbuvir (LDV/SOF) or ombitasvir-paritaprevir-ritonavir, and dasabuvir (PrOD). AUDIT-C scores were categorized as 0 (abstinence), 1-3 (low-level drinking) and 4-12 (unhealthy drinking) in men or 0, 1-2 and 3-12 in women.



Among 17,487 patients who initiated DAAs, 15,151 (87%) completed AUDIT-C screening: 10,387 (68.5%) were categorized as abstinent, 3422 (22.6%) as low-level drinking and 1342 (8.9%) as unhealthy drinking. There were no significant differences in sustained virologic response (SVR) rates between abstinent (SVR 91%; 95% CI: 91-92%), low-level drinking (SVR 93%; 95% CI 92-94%) or unhealthy drinking (SVR 91%; 95% 89-92) categories in univariable analysis or in multivariable logistic regression models. However, after imputing missing SVR data, unhealthy drinkers were less likely to achieve SVR in multivariable analysis (AOR 0.75, 95% CI 0.60-0.92).



Absolute SVR rates were uniformly high among all persons regardless of alcohol use, with only minor differences in those who report unhealthy drinking, which supports clinical guidelines that do not recommend excluding persons with alcohol use.
General Internal Medicine, Seattle, WA, United States.
Judith I
JI
Tsui
Department of Health Services, University of Washington, Seattle, WA, United States; Health Services Research and Development, Seattle, WA, United States; Center of Innovation for Veteran-Centered Value-Driven Care (COIN), Veterans Affairs Puget Sound Health Care System, Seattle, WA, United States.
Emily C
EC
Williams
Health Services Research and Development, Seattle, WA, United States.
Pamela K
PK
Green
Health Services Research and Development, Seattle, WA, United States.
Kristin
K
Berry
Division of Gastroenterology/Medicine, Veterans Affairs Puget Sound Health Care System and University of Washington, Seattle, WA, United States.
Feng
F
Su
Health Services Research and Development, Seattle, WA, United States; Division of Gastroenterology/Medicine, Veterans Affairs Puget Sound Health Care System and University of Washington, Seattle, WA, United States. Electronic address: georgei@medicine.washington.edu.
George N
GN
Ioannou
D000368:Aged; D000428:Alcohol Drinking / Q000188:drug therapy / Q000453:epidemiology; D000437:Alcoholism / Q000188:drug therapy* / Q000453:epidemiology*; D000998:Antiviral Agents / Q000494:pharmacology / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D016174:Hepacivirus / Q000187:drug effects; D006526:Hepatitis C / Q000188:drug therapy* / Q000453:epidemiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D000069474:Sofosbuvir / Q000494:pharmacology / Q000627:therapeutic use; D011795:Surveys and Questionnaires; D000072230:Sustained Virologic Response; D016896:Treatment Outcome
D000998:Antiviral Agents; D000069474:Sofosbuvir
AUDIT-C; Direct antiviral agents; Hepatitis c treatment