Stromal COX-2 signaling are correlated with colorectal cancer: A review.
Cyclooxygenase-2 (COX-2) and its product prostaglandin E2(PGE2) play a critical role in development and progression of colorectal cancer. Yet the detailed mechanistic pathways of COX-2 mediated signaling are still controversial and the role of COX-2 interaction in epithelial-stromal compartments on colorectal carcinogenesis is not well-understood either. In this review, we provide experimental evidence to support that (1) COX-2 signaling plays a major role in development and progression of colorectal cancer; (2) Stromal fibroblasts are a major source of COX-2 and PGE2; (3) Stromal-epithelial interaction mediated by COX-2 signaling promotes colorectal carcinogenesis and (4) Inhibition of stromal COX-2 signaling is necessary to control colorectal cancer. In conclusion, the evidences summarized in the review reflect recent advances and insight in mechanistic studies of colorectal cancer which can help the audiences to further understand the etiology and the control of this disease.
R&D Department, TissueTech, Inc., Ocular Surface Center, Ocular Surface Research & Education Foundation, Miami, FL, USA.
Chen-Wei
CW
Su
Dalian Central Hospital, Dalian City, Liaoning Province, China.
Yuan
Y
Zhang
R&D Department, TissueTech, Inc., Ocular Surface Center, Ocular Surface Research & Education Foundation, Miami, FL, USA. Electronic address: yzhu@tissuetechinc.com.
Ying-Ting
YT
Zhu
D002471:Cell Transformation, Neoplastic; D015179:Colorectal Neoplasms / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D051546:Cyclooxygenase 2 / Q000378:metabolism*; D052246:Cyclooxygenase 2 Inhibitors / Q000627:therapeutic use; D006801:Humans; D015398:Signal Transduction; D017154:Stromal Cells / Q000378:metabolism*
D052246:Cyclooxygenase 2 Inhibitors; D051546:Cyclooxygenase 2
Cancer; Colorectal; Cyclooxygenase-2; Invasion; Proliferation; Prostaglandin