Sorting receptor SORLA: cellular mechanisms and implications for disease.
Sorting-related receptor with A-type repeats (SORLA) is an intracellular sorting receptor that directs cargo proteins, such as kinases, phosphatases, and signaling receptors, to their correct location within the cell. The activity of SORLA assures proper function of cells and tissues, and receptor dysfunction is the underlying cause of common human malignancies, including Alzheimer's disease, atherosclerosis, and obesity. Here, we discuss the molecular mechanisms that govern sorting of SORLA and its cargo in multiple cell types, and why genetic defects in this receptor results in devastating diseases.
Max-Delbrueck-Center for Molecular Medicine, Robert-Roessle-Str. 10, 13125, Berlin, Germany. vanessa.schmidt@mdc-berlin.de.
Vanessa
V
Schmidt
Max-Delbrueck-Center for Molecular Medicine, Robert-Roessle-Str. 10, 13125, Berlin, Germany.
Aygul
A
Subkhangulova
Max-Delbrueck-Center for Molecular Medicine, Robert-Roessle-Str. 10, 13125, Berlin, Germany.|Berlin Institute of Health, Berlin, Germany.
Thomas E
TE
Willnow
D000544:Alzheimer Disease / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D000595:Amino Acid Sequence; D000818:Animals; D050197:Atherosclerosis / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D001921:Brain / Q000378:metabolism / Q000473:pathology; D020022:Genetic Predisposition to Disease; D006801:Humans; D026502:LDL-Receptor Related Proteins / Q000032:analysis / Q000235:genetics* / Q000378:metabolism*; D026901:Membrane Transport Proteins / Q000032:analysis / Q000235:genetics* / Q000378:metabolism*; D009414:Nerve Growth Factors / Q000378:metabolism; D009765:Obesity / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D011487:Protein Conformation; D021381:Protein Transport; D015398:Signal Transduction
D026502:LDL-Receptor Related Proteins; D026901:Membrane Transport Proteins; D009414:Nerve Growth Factors; C102582:SORL1 protein, human
Alzheimer’s disease; GGA; Obesity; Protein sorting; Retromer; VPS10P domain receptors