Risk factors for intestinal metaplasia in a southeastern Chinese population: an analysis of 28,745 cases.
OBJECTIVE
To identify risk factors for intestinal metaplasia in a southeastern Chinese population.


METHODS
Subjects who underwent upper GI endoscopy and endoscopic biopsy in the First Affiliated Hospital of Nanjing Medical University from 2008 to 2013 were included into this study. Various demographic, geographic, clinical and pathological data were analyzed separately to identify risk factors for intestinal metaplasia.


RESULTS
The incidence of intestinal metaplasia differed significantly in 17 municipal areas ranging from 16.79 to 38.56% and was positively correlated with the age range of 40-70 years, male gender, gastric ulcer, bile reflux, Helicobacter pylori infection, atrophic gastritis, dysplasia, gastric cancer, degree of chronic and acute inflammation, and gross domestic product per capita (P < 0.01). Multivariate linear regression analysis indicated that only gross domestic product per capita revealed a significant difference in the incidence of intestinal metaplasia among all factors mentioned.


CONCLUSIONS
This study confirms age, male gender, gastric ulcer, bile reflux, H. pylori infection, severe degree of chronic and acute inflammation to be the risk factors for intestinal metaplasia. We speculate that the gross domestic product per capita of different areas may be a potential independent risk factor impacting the incidence of intestinal metaplasia.
Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, No. 300 Guangzhou Road, Nanjing, 210029, Jiangsu, China.
Jian-Xia
JX
Jiang
Department of Gastroenterology, Sir Run Run Hospital Affiliated to Nanjing Medical University, Nanjing, 211100, Jiangsu, China.
Qing
Q
Liu
Department of Gastroenterology, Shengze Hospital of Nanjing Medical University, Suzhou, 215228, Jiangsu, China.
Bing
B
Zhao
Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, No. 300 Guangzhou Road, Nanjing, 210029, Jiangsu, China.
Hai-Han
HH
Zhang
Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, No. 300 Guangzhou Road, Nanjing, 210029, Jiangsu, China.
Huai-Ming
HM
Sang
Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, No. 300 Guangzhou Road, Nanjing, 210029, Jiangsu, China.
Soyfoo-Muhammad
SM
Djaleel
Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, No. 300 Guangzhou Road, Nanjing, 210029, Jiangsu, China.
Guo-Xin
GX
Zhang
Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, No. 300 Guangzhou Road, Nanjing, 210029, Jiangsu, China. xushfu@126.com.
Shun-Fu
SF
Xu
D000328:Adult; D000368:Aged; D001706:Biopsy; D002681:China; D004724:Endoscopy; D005260:Female; D005753:Gastric Mucosa / Q000382:microbiology / Q000473:pathology; D016481:Helicobacter Infections / Q000453:epidemiology* / Q000382:microbiology / Q000473:pathology; D016480:Helicobacter pylori / Q000472:pathogenicity; D006801:Humans; D007249:Inflammation / Q000453:epidemiology* / Q000382:microbiology / Q000473:pathology; D007414:Intestinal Neoplasms / Q000453:epidemiology* / Q000382:microbiology / Q000473:pathology; D008297:Male; D008679:Metaplasia / Q000453:epidemiology* / Q000382:microbiology / Q000473:pathology; D008875:Middle Aged; D012307:Risk Factors
Gross domestic product per capita; Helicobacter pylori infection; Inflammation; Intestinal metaplasia; Risk factors