Highly sensitive and selective erythromycin nanosensor employing fiber optic SPR/ERY imprinted nanostructure: Application in milk and honey.
An erythromycin (ERY) detection method is proposed using the fiber optic core decorated with the coatings of silver and an over layer of ERY imprinted nanoparticles. Synthesis of ERY imprinted nanoparticles is carried out using miniemulsion method. The operating range of the sensor is observed to be from 1.62×10-3to 100µM while the sensor possesses the linear response for ERY concentration range from 0.1 to 5µM. The sensing method shows a maximum sensitivity of 205nm/µM near ERY concentration of 0.01µM. The detection limit and the quantification limit of the sensor are found to be 1.62×10-3µM and 6.14×10-3µM, respectively. The sensor's applicability in real samples is also examined and is found to be in good agreement for the industrial application. The sensor possesses numerous advantages like fast response time (<15s), simple, low cost, highly selective along with abilities towards online monitoring and remote sensing of analyte.
Department of Physics, Indian Institute of Technology Delhi, New Delhi 110016, India.
Anand M
AM
Shrivastav
Department of Physics, Indian Institute of Technology Delhi, New Delhi 110016, India.
Sruthi P
SP
Usha
Department of Physics, Indian Institute of Technology Delhi, New Delhi 110016, India. Electronic address: bdgupta@physics.iitd.ernet.in.
Banshi D
BD
Gupta
D000818:Animals; D015374:Biosensing Techniques; D004917:Erythromycin / Q000737:chemistry / Q000302:isolation & purification*; D005336:Fiber Optic Technology; D005506:Food Contamination / Q000032:analysis*; D006722:Honey / Q000032:analysis; D057230:Limit of Detection; D008892:Milk / Q000737:chemistry; D049329:Nanostructures / Q000737:chemistry; D012834:Silver / Q000737:chemistry; D020349:Surface Plasmon Resonance
D012834:Silver; D004917:Erythromycin
Erythromycin; Molecular imprinted nanoparticles; Optical fiber; Sensor; Surface plasmon resonance