Hemorheological Alteration in Patients Clinically Diagnosed with Chronic Liver Diseases.
Since liver function is changed by chronic liver diseases, chronic liver disease can lead to different hemorheological alterations during the course of the progression. This study aims to compare alterations in whole blood viscosity in patients with chronic liver disease, focusing on the gender effect. Chronic liver diseases were classified into three categories by patient's history, serologic markers, and radiologic findings: nonalcoholic fatty liver disease (NAFLD) (n = 63), chronic viral hepatitis B and C (n = 50), and liver cirrhosis (LC) (n = 35). Whole blood viscosity was measured by automated scanning capillary tube viscometer, while liver stiffness was measured by transient elastography using FibroScan®. Both systolic and diastolic whole blood viscosities were significantly lower in patients with LC than NAFLD and chronic viral hepatitis (P < 0.001) in male patients, but not in female patients. In correlation analysis, there were inverse relationships between both systolic and diastolic whole blood viscosity and liver stiffness (systolic: r = -0.25, diastolic: r = -0.22). Whole blood viscosity was significantly lower in male patients with LC than NAFLD or chronic viral hepatitis. Our data suggest that whole blood viscosity test can become a useful tool for classifying chronic liver disease and determining the prognosis for different types of chronic liver diseases.
Division of Hepatology, Department of Internal Medicine, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, Korea.
Bohyun
http://orcid.org/0000-0002-6286-0036
B
Jang
Division of Hepatology, Department of Internal Medicine, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, Korea.
Ji Won
http://orcid.org/0000-0003-1456-1450
JW
Han
Division of Hepatology, Department of Internal Medicine, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, Korea.
Pil Soo
http://orcid.org/0000-0002-5780-9607
PS
Sung
Division of Hepatology, Department of Internal Medicine, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, Korea.
Jeong Won
http://orcid.org/0000-0003-3255-8474
JW
Jang
Division of Hepatology, Department of Internal Medicine, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, Korea.
Si Hyun
http://orcid.org/0000-0003-1727-7842
SH
Bae
Division of Hepatology, Department of Internal Medicine, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, Korea.
Jong Young
http://orcid.org/0000-0001-7833-0307
JY
Choi
Department of Mechanical Engineering and Mechanics, Drexel University, Philadelphia, PA, USA.
Young I
http://orcid.org/0000-0003-2001-4859
YI
Cho
Division of Hepatology, Department of Internal Medicine, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, Korea. yoonsk@catholic.ac.kr.
Seung Kew
http://orcid.org/0000-0002-4476-4868
SK
Yoon
D001809:Blood Viscosity / Q000502:physiology*; D002908:Chronic Disease; D054459:Elasticity Imaging Techniques; D005260:Female; D019694:Hepatitis B, Chronic / Q000175:diagnosis / Q000000981:diagnostic imaging; D019698:Hepatitis C, Chronic / Q000175:diagnosis / Q000000981:diagnostic imaging; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging / Q000503:physiopathology; D008103:Liver Cirrhosis / Q000175:diagnosis / Q000000981:diagnostic imaging; D008107:Liver Diseases / Q000175:diagnosis*; D008297:Male; D065626:Non-alcoholic Fatty Liver Disease / Q000175:diagnosis / Q000000981:diagnostic imaging; D012737:Sex Factors
Chronic Liver Disease; Hemorheology; Whole Blood Viscosity