Serum 25-hydroxyvitamin D concentrations in dogs with osteosarcoma do not differ from those of age- and weight-matched control dogs.
Vitamin D concentrations show an inverse correlation with incidence of certain tumors in people and dogs. Additionally, human osteosarcoma has been associated with dysregulation of vitamin D-dependent pathways. The study objective was to compare serum 25-hydroxyvitamin D2and 25-hydroxyvitamin D3in 20 dogs with osteosarcoma to age- and weight-matched control dogs. We hypothesized that dogs with osteosarcoma would have lower serum 25-hydroxyvitamin D than control dogs. The mean 25-hydroxyvitamin D3concentrations for dogs with osteosarcoma and matched-controls were 34.95 ng/mL and 33.85 ng/mL, respectively (P = 0.784). Based on these data, 25-hydroxyvitamin D insufficiency might not be important in the pathogenesis of canine osteosarcoma.
Veterinary Health Complex, North Carolina State University, 1060 William Moore Dr., Raleigh, NC 27607, USA.
Jennifer L
JL
Willcox
Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27514, USA.
Catherine
C
Hammett-Stabler
Veterinary Health Complex, North Carolina State University, 1060 William Moore Dr., Raleigh, NC 27607, USA. Electronic address: marlene_hauck@ncsu.edu.
Marlene L
ML
Hauck
D015652:25-Hydroxyvitamin D 2 / Q000097:blood*; D000367:Age Factors; D000818:Animals; D001835:Body Weight; D001859:Bone Neoplasms / Q000097:blood / Q000209:etiology / Q000662:veterinary*; D002112:Calcifediol / Q000097:blood*; D016022:Case-Control Studies; D004283:Dog Diseases / Q000097:blood / Q000209:etiology*; D004285:Dogs; D012516:Osteosarcoma / Q000097:blood / Q000209:etiology / Q000662:veterinary*; D014815:Vitamins / Q000097:blood*
D014815:Vitamins; D015652:25-Hydroxyvitamin D 2; D002112:Calcifediol
Bone; Cancer; Canine; Osteosarcoma; Vitamin D