Comparison of Efficacy of Granisetron and Promethazine in Control of Hyperemesis Gravidarum.
Hyperemesis gravidarum is the third leading cause of hospitalization during pregnancy. 5-HT3-receptor antagonists are the most effective against chemotherapy-induced nausea and vomiting and radiation. This randomized study aimed to compare and evaluate the efficacies of granisetron and promethazine for controlling nausea and vomiting of pregnancy.



The included patients were administered (oral and intravenous) granisetron and promethazine randomly. The patients were evaluated for nausea and vomiting by a senior gynecology resident blinded to designated drugs.



This study revealed that granisetron significantly decreased nausea and vomiting in pregnant women (p< 0.05). Greater patient satisfaction and lesser adverse drug reactions in women receiving granisetron observed in this study suggest that it can be introduced as a more effective and safer drug in comparison with promethazine.



Considering the prevalence of nausea and vomiting of pregnancy and hyperemesis gravidarum, we can state that it is a health-related problem with economic, social and psychological dimensions. All efforts especially simple outpatient strategies to reduce its severity will help the pregnant woman continue her pregnancy with more satisfaction.
Obstetrics and Gynecology Department, Dr. Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Ashraf
A
Aleyasin
Abnormal uterine Bleeding Research Center, Semnan University of Medical Sciences, Semnan, Iran.
Elham
E
Saffarieh
Pharmaceutical Care Department, Dr. Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Hassan
H
Torkamandi
Pharmaceutical Care Department, Dr. Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Somayeh
S
Hanafi
Pharmaceutical Care Department, Dr. Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Fariborz
F
Sadeghi
Obstetrics and Gynecology Department, Dr. Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Atossa
A
Mahdavi
Obstetrics and Gynecology Department, Dr. Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Fatemeh
F
Bahmaei
Clinical Pharmacy Department, College of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran ; Research Center for Rational Use of Drugs, Tehran University of Medical Sciences, Tehran, Iran.
Mohammadreza
M
Javadi
Granisetron; Hyperemesis Gravidarum; Promethazine