[Value of combined measurement of intestinal fatty acid-binding protein and fecal calprotectin in diagnosis of necrotizing enterocolitis in full-term neonates].
OBJECTIVE
To study the value of combined measurement of intestinal fatty acid-binding protein (I-FABP) and fecal calprotectin (FC) in the diagnosis of necrotizing enterocolitis (NEC) in full-term neonates.


METHODS
A total of 36 full-term neonates with NEC (case group) and 39 neonates without digestive system diseases (control group) were enrolled as study subjects. ELISA was used to measure the serum I-FABP level and fecal FC level, and the clinical value of I-FABP combined with FC in the diagnosis of NEC was evaluated.


RESULTS
The case group had significantly higher I-FABP and FC levels than the control group (P<0.05). In the case group, serum I-FABP level was positively correlated with fecal FC level (r=0.71, P<0.05). In the diagnosis of NEC, I-FABP alone, FC alone, and I-FABP/FC combination had sensitivities of 83.3%, 81.5%, and 79.5%, specificities of 72.5%, 75.8%, and 86.3%, and areas under the ROC curve (AUCs) of 0.82, 0.81, and 0.88. The combined measurement showed significantly higher specificity and AUC than single measurement (P<0.05).


CONCLUSIONS
Children with NEC have significant increases in I-FABP and FC levels, and there is a correlation between them. Combined measurement of I-FABP and FC can increase the specificity of the diagnosis of NEC.
Department of Pediatrics, First People's Hospital of Yunnan Province, Kunming 650034, China. ijhww76wuyu0@163.com.
Yun-Fen
YF
Tian
Li
L
Li
Hong-Ying
HY
Mi
Chun-Rong
CR
Huang-Pu
Shan
S
He
Xiao-Yan
XY
Xu
Yong-Jiu
YJ
Cao
D020345:Enterocolitis, Necrotizing / Q000175:diagnosis*; D050556:Fatty Acid-Binding Proteins / Q000097:blood*; D005243:Feces / Q000737:chemistry*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D039841:Leukocyte L1 Antigen Complex / Q000032:analysis*; D008297:Male
D050556:Fatty Acid-Binding Proteins; D039841:Leukocyte L1 Antigen Complex