Factors That Affect Tissue-Engineered Skeletal Muscle Function and Physiology.
Tissue-engineered skeletal muscle has the promise to be a tool for studying physiology, screening muscle-active drugs, and clinical replacement of damaged muscle. To maximize the potential benefits of engineered muscle, it is important to understand the factors required for tissue formation and how these affect muscle function. In this review, we evaluate how biomaterials, cell source, media components, and bioreactor interventions impact muscle function and phenotype.
Alastair
A
Khodabukus
Keith
K
Baar
D000818:Animals; D019149:Bioreactors; D003470:Culture Media / Q000494:pharmacology; D004558:Electric Stimulation; D006801:Humans; D018482:Muscle, Skeletal / Q000187:drug effects / Q000502:physiology*; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds / Q000737:chemistry
D003470:Culture Media