Elevated Levels of Plasma Superoxide Dismutases 1 and 2 in Patients with Coronary Artery Disease.
Aims. To measure plasma levels of superoxide dismutases 1, 2, and 3 (SOD1, 2, 3) and determine whether SODs can function as biomarkers for coronary artery disease (CAD).Patients & Methods. Patient groups were as follows: patients with stable angina pectoris (SAP,n= 33), patients with acute coronary syndrome (ACS,n= 49), and controls (n= 42). Protein quantification was done using ELISA.Results. The concentrations of plasma SOD1 and SOD2 were higher in CAD than in healthy controls. No difference in SOD3 levels between CAD and control groups was found. Limited correlations were found between SODs and gender, age, and severity of coronary artery stenosis.Conclusions. Plasma levels of SOD1 and SOD2 were elevated in patients with CAD and might serve as surrogate biomarkers for CAD.
Department of Cardiology Medicine, Affiliated Dongyang Hospital of Wenzhou Medical University, Dongyang, Zhejiang, China.
Ji-Ren
0000-0001-7158-7222
JR
Peng
Department of Science Education, Affiliated Dongyang Hospital of Wenzhou Medical University, Dongyang, Zhejiang, China.
Ting-Ting
TT
Lu
Graduate Institute of Biomedical Science, China Medical University, Taichung, Taiwan; Department of Computer Science and Information Engineering, Asia University, Taichung, Taiwan.
Hao-Teng
HT
Chang
Department of Cardiology Medicine, Affiliated Dongyang Hospital of Wenzhou Medical University, Dongyang, Zhejiang, China.
Xuan
X
Ge
Department of Cardiology Medicine, Affiliated Dongyang Hospital of Wenzhou Medical University, Dongyang, Zhejiang, China.
Bian
B
Huang
Department of Cardiology Medicine, Affiliated Dongyang Hospital of Wenzhou Medical University, Dongyang, Zhejiang, China.
Wei-Min
0000-0002-9065-4432
WM
Li
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood*; D015331:Cohort Studies; D003324:Coronary Artery Disease / Q000097:blood* / Q000175:diagnosis / Q000201:enzymology* / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D013482:Superoxide Dismutase / Q000097:blood*
D015415:Biomarkers; D013482:Superoxide Dismutase