Built-in microscale electrostatic fields induced by anatase-rutile-phase transition in selective areas promote osteogenesis.
Bone has a built-in electric field because of the presence of piezoelectric collagen. To date, only externally applied electric fields have been used to direct cell behavior; however, these fields are not safe or practical forin vivouse. In this work, for the first time, we use a periodic microscale electric field (MEF) built into a titanium implant to induce osteogenesis. Such a MEF is generated by the periodic organization of a junction made of two parallel semiconducting TiO2zones: anatase and rutile with lower and higher electron densities, respectively. The junctions were formed through anatase-rutile-phase transition in selective areas using laser irradiation on the implants. Thein vitroandin vivostudies confirmed that the built-in MEF was an efficient electrical cue for inducing osteogenic differentiation in the absence of osteogenic supplements and promoted bone regeneration around the implants. Our work opens up a new avenue toward bone repair and regeneration using built-in MEF.
School of Materials Science and Engineering, South China University of Technology, Guangzhou, China.
Chengyun
C
Ning
School of Materials Science and Engineering, South China University of Technology, Guangzhou, China.
Peng
P
Yu
Department of Chemistry and Biochemistry, Stephenson Life Sciences Research Center, University of Oklahoma, Norman, OK, USA.
Ye
Y
Zhu
General Hospital of Guangzhou Military Command of PLA, Guangzhou, China.
Mengyu
M
Yao
Dental Department, Baoan Central Hospital of Shenzhen, Shenzhen, China.
Xiaojing
X
Zhu
General Hospital of Guangzhou Military Command of PLA, Guangzhou, China.
Xiaolan
X
Wang
General Hospital of Guangzhou Military Command of PLA, Guangzhou, China.
Zefeng
Z
Lin
School of Materials Science and Engineering, South China University of Technology, Guangzhou, China.
Weiping
W
Li
School of Materials Science and Engineering, South China University of Technology, Guangzhou, China.
Shuangying
S
Wang
Institute of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou, China.
Guoxin
G
Tan
General Hospital of Guangzhou Military Command of PLA, Guangzhou, China.
Yu
Y
Zhang
School of Materials Science and Engineering, South China University of Technology, Guangzhou, China.
Yingjun
Y
Wang
Department of Chemistry and Biochemistry, Stephenson Life Sciences Research Center, University of Oklahoma, Norman, OK, USA; School of Materials Science and Engineering, Zhejiang University, Hangzhou, Zhejiang, China.
Chuanbin
C
Mao