Oncogene-directed alterations in cancer cell metabolism.
Oncogenes are key drivers of tumor growth. Although several cancer-driving mechanisms have been identified, the role of oncogenes in shaping metabolic patterns in cancer cells is only beginning to be appreciated. Recent studies show that oncogenes directly regulate critical metabolic enzymes and metabolic signaling pathways. Here, we present evidence for oncogene-directed cancer metabolic regulation and discuss the importance of identifying underlying mechanisms that can be targeted for developing precision cancer therapies.
Department of Pathology, Yale University School of Medicine, New Haven, CT, USA, 06510.
Arvindhan
A
Nagarajan
Department of Pathology, Yale University School of Medicine, New Haven, CT, USA, 06510.
Parmanand
P
Malvi
Department of Pathology, Yale University School of Medicine, New Haven, CT, USA, 06510; Yale Cancer Center, Yale University School of Medicine, New Haven, CT, USA, 06510.
Narendra
N
Wajapeyee
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D006801:Humans; D053858:Metabolic Networks and Pathways; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000378:metabolism*; D009857:Oncogenes
D000970:Antineoplastic Agents
Oncogene; metabolic pathways; precision cancer therapies; tumor growth