Predictors of general discomfort, limitations in activities of daily living and intention of a second donation in unrelated hematopoietic stem cell donation.
We performed a retrospective study of 1868 consecutive unrelated donors to predict the risk factors related to general discomfort, limitations in activities of daily living (ADLs) and intention of a second donation in hematopoietic stem cell (HSC) donation. General discomfort and limitations in ADLs were assessed by numerical measurement (scores of 0-10) and donor's intention of a second donation by yes or no reply. The post-donation questionnaires were completed within 48 h after HSC collection and at 1 week, 4 weeks, and 4 months thereafter. Predictors of general discomfort included female sex (P<0.0001), bone marrow (BM) collection (P<0.0001) or PBSC collection through a central line (CL; P=0.0349), 2-day collection (P=0.0150) and negative or undetermined intention of a second donation on day 1 (P<0.0001). Predictors of limitations in ADLs included age group of 30-39 years (P=0.0046), female sex (P<0.0001), BM collection (P<0.0001) or PBSC collection through a CL (P<0.0001) and negative or undetermined intention of a second donation on day 1 (P<0.0001). The only predictor of positive intention of a second donation was male sex (P=0.0007). Age, sex and collection method and period should be considered risk factors when unrelated HSC donation is performed.
Division of Hematology-Oncology, Department of Internal Medicine, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, South Korea.
M H
MH
Lee
Korea Marrow Donor Program, Seoul, South Korea.
J H
JH
Jang
Clinical Research Institute, Konkuk University Medical Center, Seoul, South Korea.
H J
HJ
Min
Korea Marrow Donor Program, Seoul, South Korea.
H I
HI
Jang
Korea Marrow Donor Program, Seoul, South Korea.
J H
JH
Nah
Division of Pediatric Hematology and Oncology, Department of Pediatrics, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.
C J
CJ
Lyu
Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, South Korea.
K-S
KS
Han
Department of Hematology-Oncology, Soon Chun Hyang University Hospital, Seoul, South Korea.
J H
JH
Won
Department of Pediatrics, Hanyang University Medical Center, Hanyang University College of Medicine, Seoul, South Korea.
Y-H
YH
Lee
Department of Internal Medicine, Bundang Cha Hospital, Seongnam, South Korea.
S Y
SY
Chong
Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, South Korea.
Y C
YC
Mun
Department of Hematology and Oncology, Busan Paik Hospital, Inje University College of Medicine, Busan, South Korea.
W S
WS
Lee
Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
S J
SJ
Kim
Division of Hematology-Oncology, Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea.
I
I
Kim
D000203:Activities of Daily Living; D000328:Adult; D000367:Age Factors; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000072916:Peripheral Blood Stem Cells; D012189:Retrospective Studies; D012737:Sex Factors; D061349:Unrelated Donors