Screening first-degree relatives of patients with idiopathic dilated cardiomyopathy.
BACKGROUND
This study evaluated whether subclinical myocardial dysfunction occurs in first-degree relatives of patients with idiopathic dilated cardiomyopathy (IDCM), using strain echocardiographic imaging, before apparent left ventricular (LV) failure is observed.


METHODS
The study comprised 77 subjects aged 16-63 years who had first-degree relatives with a previous or new diagnosis of IDCM. LV myocardial deformation parameters of the first-degree relatives with normal LVEF (≥55%) values, as assessed using 2D echocardiography, were evaluated. The findings of the first-degree relatives were compared with an age- and sex-matched control group (n = 86).


RESULTS
No difference in terms of age, gender, and body surface area was detected between first-degree relatives and controls. First-degree relatives of IDCM patients had significantly lower LVEF (62.04 ± 5.8% vs. 65.65 ± 6.3%, p < 0.001) and FS values (39.4 ± 6.6 vs. 41.45 ± 5.5, p = 0.03) compared with the controls. Assessment of LV deformation parameters revealed that LV global longitudinal strain (-17.34 ± 2.19% vs. -19.21 ± 2.16%, p < 0.001) and strain rate (0.94 ± 0.14 s-1vs. 1.03 ± 0.14 s-1, p < 0.001), radial strain (34.47 ± 9.14% vs 42.79 ± 11.91%, p < 0.001) and strain rate (1.6 ± 0.38 s-1vs. 1.75 ± 0.29 s-1, p = 0.006), circumferential strain (-6.07 ± 2.83% vs. -18.29 ± 3.39%, p < 0.001) and strain rate (1.09 ± 0.24 s-1vs. 1.2 ± 0.25 s-1, p = 0.004), and torsion (10.07 ± 5.18o/cm vs. 12.42 ± 5.78o/cm, p = 0.009) were significantly reduced in first-degree relatives compared with controls.


CONCLUSIONS
LV deformation parameters are impaired in first-degree relatives of patients with IDCM. Screening of this population using standard 2D echocardiography and strain imaging may provide early detection of those with subclinical myocardial dysfunction.
Department of Cardiology, Ege University Faculty of Medicine, Izmir, Turkey.
M
M
Sefa Okten
Department of Cardiology, Tepecik Training and Research Hospital, Izmir, Turkey. kamiltuluce@gmail.com.
K
K
Tuluce
Department of Cardiology, Katip Celebi University Ataturk Training and Research Hospital, , Izmir, Turkey.
S
S
Yakar Tuluce
Department of Cardiology, Ege University Faculty of Medicine, Izmir, Turkey.
S
S
Kilic
Department of Cardiology, Ege University Faculty of Medicine, Izmir, Turkey.
H
H
Soner Kemal
Department of Cardiology, Tepecik Training and Research Hospital, Izmir, Turkey.
A
A
Sayin
Department of Cardiology, Ege University Faculty of Medicine, Izmir, Turkey.
O
O
Vuran
Department of Cardiology, Ege University Faculty of Medicine, Izmir, Turkey.
B
B
Yagmur
Department of Cardiology, Ege University Faculty of Medicine, Izmir, Turkey.
I
I
Mutlu
Department of Cardiology, Ege University Faculty of Medicine, Izmir, Turkey.
E
E
Simsek
Department of Cardiology, Ege University Faculty of Medicine, Izmir, Turkey.
C
C
Soydas Cinar
Department of Cardiology, Ege University Faculty of Medicine, Izmir, Turkey.
C
C
Gurgun
D000293:Adolescent; D000328:Adult; D002311:Cardiomyopathy, Dilated / Q000000981:diagnostic imaging / Q000235:genetics* / Q000517:prevention & control; D004452:Echocardiography / Q000379:methods*; D005260:Female; D005820:Genetic Testing; D006352:Heart Ventricles / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging / Q000235:genetics* / Q000517:prevention & control; D055815:Young Adult
Cardiomyopathy, familial idiopathic; Cardiomyopathy, idiopathic dilated; Dilated cardiomyopathy; Echocardiography