Novel Faces of Fibroblast Growth Factor 23 (FGF23): Iron Deficiency, Inflammation, Insulin Resistance, Left Ventricular Hypertrophy, Proteinuria and Acute Kidney Injury.
FGF23 is a hormone that appears as the core regulator of phosphate metabolism. Great deal of data has accumulated to demonstrate increased FGF23 secretion from the bone to compensate for even subtle increases in serum phosphorus long before intact PTH. However, recent evidence points to the fact that actions and interactions of FGF23 are not limited solely to phosphate metabolism. FGF23 may be implicated in iron metabolism and erythropoiesis, inflammation, insulin resistance, proteinuria, acute kidney injury and left ventricular hypertrophy. In this review, we will summarize latest experimental and clinical data examining impact of FGF23 on aforementioned pathophysiologic pathways/disorders.
Division of Nephrology, Department of Medicine, Koc University School of Medicine, Sariyer, Istanbul, Turkey. mkanbay@ku.edu.tr.
Mehmet
M
Kanbay
Department of Nephrology, VU University Medical Center, Amsterdam, The Netherlands.|Institute for Cardiovascular Research VU (ICaR-VU), VU University Medical Center, Amsterdam, The Netherlands.
Marc
M
Vervloet
Renal Unit, San Paolo Hospital Milan, Department of Health and Science, University of Milan, Milan, Italy.
Mario
M
Cozzolino
Nephrology Clinic, Dialysis and Renal Transplant Center, 'C.I. PARHON' University Hospital, 'Grigore T. Popa' University of Medicine, Iasi, Romania.
Dimitrie
D
Siriopol
Nephrology Clinic, Dialysis and Renal Transplant Center, 'C.I. PARHON' University Hospital, 'Grigore T. Popa' University of Medicine, Iasi, Romania.
Adrian
A
Covic
Renal and Transplantation Department, Guy's and St Thomas' Hospitals, London, UK.
David
D
Goldsmith
Department of Nephrology, Sakarya Training and Research Hospital, Sakarya, Turkey.
Yalcin
Y
Solak
D058186:Acute Kidney Injury / Q000378:metabolism*; D000818:Animals; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000378:metabolism*; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000378:metabolism*; D007249:Inflammation / Q000378:metabolism*; D007333:Insulin Resistance / Q000502:physiology*; D000090463:Iron Deficiencies; D011507:Proteinuria / Q000378:metabolism*
C000717427:FGF23 protein, human; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23
Acute kidney injury; Fibroblast growth factor 23; Inflammation; Insulin resistance; Left ventricular hypertrophy; Proteinuria