Combined optical coherence tomography and hyperspectral imaging using a double-clad fiber coupler.
This work demonstrates the combination of optical coherence tomography (OCT) and hyperspectral imaging (HSI) using a double-clad optical fiber coupler. The single-mode core of the fiber is used for OCT imaging, while the inner cladding of the double-clad fiber provides an efficient way to capture the reflectance spectrum of the sample. The combination of both methods enables three-dimensional acquisition of the sample morphology with OCT, enhanced with complementary molecular information contained in the hyperspectral image. The HSI data can be used to highlight the presence of specific molecules with characteristic absorption peaks or to produce true color images overlaid on the OCT volume for improved tissue identification by the clinician. Such a system could be implemented in a number of clinical endoscopic applications and could improve the current practice in tissue characterization, diagnosis, and surgical guidance.
École Polytechnique Montreal, Department of Engineering Physics, C.P. 6079 Succ. Centre-ville, Montréal, Canada.
Robin
R
Guay-Lord
École Polytechnique Montreal, Department of Engineering Physics, C.P. 6079 Succ. Centre-ville, Montréal, Canada.
Xavier
X
Attendu
Stanford University, E.L. Ginzton Laboratory, 350 Serra Mall, Packa Road, Room 361, Stanford, California 94305, United States.
Kristen L
KL
Lurie
École Polytechnique Montreal, Department of Engineering Physics, C.P. 6079 Succ. Centre-ville, Montréal, Canada.
Lucas
L
Majeau
École Polytechnique Montreal, Department of Engineering Physics, C.P. 6079 Succ. Centre-ville, Montréal, CanadacCastor Optics, 5155 Avenue Decelles 1251, Pavillon J-Armand Bombardier, Montréal, Québec H3T 2B1, Canada.
Nicolas
N
Godbout
Stanford University, E.L. Ginzton Laboratory, 350 Serra Mall, Packa Road, Room 361, Stanford, California 94305, United States.
Audrey K Ellerbee
AK
Bowden
École Polytechnique Montreal, Department of Engineering Physics, C.P. 6079 Succ. Centre-ville, Montréal, Canada.
Mathias
M
Strupler
École Polytechnique Montreal, Department of Engineering Physics, C.P. 6079 Succ. Centre-ville, Montréal, CanadacCastor Optics, 5155 Avenue Decelles 1251, Pavillon J-Armand Bombardier, Montréal, Québec H3T 2B1, Canada.
Caroline
C
Boudoux
D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D055100:Optical Fibers; D012867:Skin / Q000000981:diagnostic imaging; D013057:Spectrum Analysis / Q000379:methods*; D041623:Tomography, Optical Coherence / Q000379:methods*