The c.553G>T Genetic Variant of the APOA5 Gene and Altered Triglyceride Levels in the Asian Population: A Meta-Analysis of Case-Control Studies.
OBJECTIVE
To explore the association of the APOA5 gene c.553G>T polymorphism with hypertriglyceridemia (HTG) susceptibility and altered triglyceride levels.


METHODS
We searched the PubMed, Google Scholar, and CNKI databases for published studies relating to analyses of these associations. Case-control and comparative studies of the association between the APOA5 c.553G>T variant and altered triglyceride levels were included. In total, the meta-analysis involved 10 studies on HTG, which provided 2219 cases and 3401 controls. To measure the correlation between the c.553G>T polymorphism and HTG susceptibility, odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. The overall OR was calculated using a random-effects model.


RESULTS
Compared with APOA5 c.553 GG carriers, c.553T carriers displayed an increased risk of HTG in the Asian population, with an overall random effects OR of 3.55 (95% CI: 2.46-5.13) in the dominant model. There was significant heterogeneity among the studies (Pheterogeneity: Chi2= 45.80, I2= 75.98%), which may be largely explained by certain patient types. Both the sensitivity analysis and publication bias suggested that the overall result was acceptable. Subgroup analysis showed a large difference in serum triglyceride levels based on the c.553 G > T polymorphism in healthy individuals and HTG patients. APOA5 c.553T carriers exhibit higher triglyceride levels than GG carriers.


CONCLUSIONS
Our results suggest that APOA5 c. 553T is an independent risk factor for HTG and increased triglyceride levels in the Asian population. APOA5 c. 553T could be employed as a genetic risk marker for HTG and increased triglyceride levels.
College of Life Science, Institute of Preventive Genomic Medicine, Northwest University , Xi'an, China .
Hongjuan
H
He
College of Life Science, Institute of Preventive Genomic Medicine, Northwest University , Xi'an, China .
Lei
L
Lei
College of Life Science, Institute of Preventive Genomic Medicine, Northwest University , Xi'an, China .
Erfei
E
Chen
College of Life Science, Institute of Preventive Genomic Medicine, Northwest University , Xi'an, China .
Jing
J
Dong
College of Life Science, Institute of Preventive Genomic Medicine, Northwest University , Xi'an, China .
Kejin
K
Zhang
College of Life Science, Institute of Preventive Genomic Medicine, Northwest University , Xi'an, China .
Jin
J
Yang
D000483:Alleles; D000072040:Apolipoprotein A-V / Q000235:genetics* / Q000378:metabolism; D001054:Apolipoproteins A / Q000235:genetics; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D002681:China; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D006801:Humans; D015228:Hypertriglyceridemia / Q000097:blood* / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D014280:Triglycerides / Q000097:blood* / Q000235:genetics
C437704:APOA5 protein, human; D000072040:Apolipoprotein A-V; D001054:Apolipoproteins A; D014280:Triglycerides
APOA5; c.553G>T (rs2075291 or G185C); hypertriglyceridemia; meta-analysis