Association and interaction of APOA5, BUD13, CETP, LIPA and health-related behavior with metabolic syndrome in a Taiwanese population.
Increased risk of developing metabolic syndrome (MetS) has been associated with the APOA5, APOC1, BRAP, BUD13, CETP, LIPA, LPL, PLCG1, and ZPR1 genes. In this replication study, we reassessed whether these genes are associated with MetS and its individual components independently and/or through complex interactions in a Taiwanese population. We also analyzed the interactions between environmental factors and these genes in influencing MetS and its individual components. A total of 3,000 Taiwanese subjects were assessed in this study. Metabolic traits such as waist circumference, triglyceride, high-density lipoprotein (HDL) cholesterol, systolic and diastolic blood pressure, and fasting glucose were measured. Our data showed a nominal association of MetS with the APOA5 rs662799, BUD13 rs11216129, BUD13 rs623908, CETP rs820299, and LIPA rs1412444 single nucleotide polymorphisms (SNPs). Moreover, APOA5 rs662799, BUD13 rs11216129, and BUD13 rs623908 were significantly associated with high triglyceride, low HDL, triglyceride, and HDL levels. Additionally, we found the interactions of APOA5 rs662799, BUD13 rs11216129, BUD13 rs623908, CETP rs820299, LIPA rs1412444, alcohol consumption, smoking status, or physical activity on MetS and its individual components. Our study indicates that the APOA5, BUD13, CETP, and LIPA genes may contribute to the risk of MetS independently as well as through gene-gene and gene-environment interactions.
Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.|Vita Genomics, Inc., Taipei, Taiwan.|TickleFish Systems Corporation, Seattle, WA, USA.
Eugene
E
Lin
Department of Public Health, Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei, Taiwan.
Po-Hsiu
PH
Kuo
Center for Neuropsychiatric Research, National Health Research Institutes, Miaoli County, Taiwan.
Yu-Li
YL
Liu
Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan.|Division of Psychiatry, National Yang-Ming University, Taipei, Taiwan.
Albert C
AC
Yang
Department of Agronomy, College of Agriculture &Natural Resources, National Chung Hsing University, Taichung, Taiwan.
Chung-Feng
CF
Kao
Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan.|Division of Psychiatry, National Yang-Ming University, Taipei, Taiwan.
Shih-Jen
SJ
Tsai
D000328:Adult; D000072040:Apolipoprotein A-V / Q000235:genetics*; D053480:Cholesterol Ester Transfer Proteins / Q000235:genetics*; D008076:Cholesterol, HDL / Q000378:metabolism; D005260:Female; D059647:Gene-Environment Interaction; D056726:Genetic Association Studies / Q000379:methods; D020022:Genetic Predisposition to Disease; D000070497:Healthy Lifestyle; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000235:genetics* / Q000378:metabolism; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D016601:RNA-Binding Proteins / Q000235:genetics*; D002787:Sterol Esterase / Q000235:genetics*; D013624:Taiwan; D055105:Waist Circumference
C437704:APOA5 protein, human; D000072040:Apolipoprotein A-V; C000595434:BUD13 homolog protein, human; C506642:CETP protein, human; D053480:Cholesterol Ester Transfer Proteins; D008076:Cholesterol, HDL; D016601:RNA-Binding Proteins; C503451:LIPA protein, human; D002787:Sterol Esterase