Effect of DA-9701, a Novel Prokinetic Agent, on Post-operative Ileus in Rats.
OBJECTIVE
Post-operative ileus (POI) is a common complication of abdominal surgery. DA-9701, an extract of Pharbitis Semen and Corydalis Tuber, is a new prokinetic agent that also alleviates visceral pain. The aim of this study was to investigate whether DA-9701 can ameliorate POI in rats.


METHODS
A total of 32 rats were divided into 4 groups: no surgery/no medication (NSNM), no surgery/medication (NSM), surgery/no medication (SNM), and surgery/medication (SM). Gastrointestinal transit (GIT), which is assessed by migration of charcoal, and cumulative stool weight were measured at 24 hours after surgery.


RESULTS
GIT was significantly more delayed in the SNM group than in the other groups (SNM vs NSNM,P< 0.001; SNM vs NSM,P< 0.001; SNM vs SM,P= 0.005). Cumulative stool weight in that group was also lower than in the no surgery groups (SNM vs NSNM,P= 0.007; SNM vs NSM,P= 0.033), and there was no significant difference between the SM group and the no surgery groups (SM vs NSM,P= 0.703; SM vs NSNM,P= 0.347).


CONCLUSIONS
DA-9701 can ameliorate POI by reducing delayed GIT and improving defecation in a rat model of POI.
Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea.
Sang Pyo
SP
Lee
Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.
Oh Young
OY
Lee
Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.
Kang Nyeong
KN
Lee
Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.
Hang Lak
HL
Lee
Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.
Ho Soon
HS
Choi
Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.
Byung Chul
BC
Yoon
Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.
Dae Won
DW
Jun
Corydalis; DA-9701; Gastrointestinal transit; Ghrelin; Ileus