[Epidemiologic, clinical and bacteriologic characteristics of pneumococcal meningitis in pediatric patients from Lima, Peru].
To describe the clinical characteristics, lethality, antibiotic susceptibility, and serotype distribution of pneumococcal meningitis in pediatric patients in Lima, Peru.
A case series of pneumococcal meningitis in children less than 16 years of age from two prospective, multicenter, passive surveillance studies of invasive pneumococcal diseases held in Lima-Peru from 2006 to 2008 and 2009 to 2011.
We report 44 pneumococcal meningitis episodes; 68.2% of them were in children less than 2 years old. The overall case fatality rate was 32.6%; 92.9% of fatal cases were in children less than 2 years of age (p<0.05). Malnutrition was associated with fatal cases (p<0.05). 64.3% of fatal cases died within the first two days. 41.9% of pneumococcal isolates were resistant to penicillin, 23.3% were intermediate resistant to ceftriaxone (none were highly resistant) and 9.3% were resistant to chloramphenicol. The most common serotypes were 6B, 14, 19F and 23F, which accounted for 68.3% of all strains; 84.1% of strains were PCV13 serotypes.
Pneumococcal meningitis continues to be a lethal disease, especially in children less than 2 years of age. Since almost two third of lethal cases lead to death within the first 48 hours, prompt diagnosis and management is critical, as well as assurance of immunization with pneumococcal vaccine.
Universidad Peruana Cayetano Heredia. Lima, Perú.
Long
L
Davalos
Universidad Peruana Cayetano Heredia. Lima, Perú.|Hospital Nacional Cayetano Heredia. Lima, Perú.
Yessica
Y
Terrazas
Universidad Peruana Cayetano Heredia. Lima, Perú.|Hospital Nacional Cayetano Heredia. Lima, Perú.
Ana
A
Quintana
Universidad Peruana Cayetano Heredia. Lima, Perú.
Martha
M
Egoavil
Universidad Peruana Cayetano Heredia. Lima, Perú.|Hospital Nacional Cayetano Heredia. Lima, Perú.
Katherine
K
Sedano
Universidad Peruana Cayetano Heredia. Lima, Perú.|Instituto Nacional de Salud del Niño. Lima, Perú.
María E
ME
Castillo
Hospital de Emergencias Pediátricas. Lima, Perú.
Isabel
I
Reyes
Universidad Peruana Cayetano Heredia. Lima, Perú.|Hospital Nacional Cayetano Heredia. Lima, Perú.
Eduardo
E
Chaparro
Hospital Nacional Edgardo Rebagliati Martins. Lima, Perú.
Wilda
W
Silva
Hospital Nacional Docente Madre-Niño San Bartolomé. Lima, Perú.
Francisco
F
Campos
Hospital Daniel A. Carrión. Lima, Perú.
Andrés
A
Saenz
Universidad Peruana Cayetano Heredia. Lima, Perú.|Hospital Nacional Cayetano Heredia. Lima, Perú.
Roger
R
Hernandez
Hospital Nacional Edgardo Rebagliati Martins. Lima, Perú.
Olguita Del
OD
Águila
Universidad Peruana Cayetano Heredia. Lima, Perú.|Hospital Nacional Cayetano Heredia. Lima, Perú.
Daniel Guillén
DG
Pinto
Universidad Peruana Cayetano Heredia. Lima, Perú.|University of Texas, School of Public Health. Houston, Texas, United States of America.
Theresa J
TJ
Ochoa
D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008586:Meningitis, Pneumococcal / Q000453:epidemiology*; D010568:Peru; D022242:Pneumococcal Vaccines / Q000627:therapeutic use*; D011446:Prospective Studies; D012703:Serotyping; D013296:Streptococcus pneumoniae
D022242:Pneumococcal Vaccines