Silver Sulfadiazine-Impregnated Hydrocolloid Dressing Is Beneficial in Split-Thickness Skin-Graft Donor Wound Healing in a Small Randomized Controlled Study.
Donor-site wound healing was tested with a silver sulfadiazine (SSD)-impregnated hydrocolloid dressing and hydrocolloid dressing applied manually by a physician on site. A total of 14 patients, 5 woman and 9 men (23-89 years old, average = 61.6 ± 18.70 years), were enrolled in this prospective controlled study. The degree of bleeding was significantly less with the SSD-impregnated than with the hydrocolloid dressing (P < .01). In the moisture meter analysis, the values of the effective contact coefficient and corneal thickness were significantly smaller with the SSD-impregnated dressing (P < .05). In the color analysis, the clarity was significantly lower with the hydrocolloid dressing after 3 months than that of intact neighboring skin (P < .01). Regarding red-green color, SSD-impregnated and hydrocolloid values were significantly greater than the intact skin value immediately after and at 3 months, and the hydrocolloid value was significantly greater than intact at 6 months (P < .01 immediately; P < .01 at 3 months and intact at 6 months) in redness. Regarding yellow-blue color, the hydrocolloid value was significantly lower than the intact skin value at 3 months (P < .05 and intact) in yellow. The extensibility was significantly lower with the hydrocolloid dressing than in intact skin immediately (P < .01), and viscoelasticity was significantly lower with the hydrocolloid dressing than in intact skin immediately and after 3 and 6 months (P < .01 immediately and at 6 months and P < .05 at 3 months). The SSD-impregnated hydrocolloid dressing led to superior wound healing, decreased the degree of bleeding, and demonstrated better corneal barrier function, clarity, color matching, and viscoelasticity in split-thickness donors.
1 Nagasaki University, Nagasaki, Japan.
Sadanori
S
Akita
1 Nagasaki University, Nagasaki, Japan.
Hiroshi
H
Yoshimoto
1 Nagasaki University, Nagasaki, Japan.
Katsuya
K
Tanaka
1 Nagasaki University, Nagasaki, Japan.
Masao
M
Oishi
1 Nagasaki University, Nagasaki, Japan.
Chikako
C
Senju
1 Nagasaki University, Nagasaki, Japan.
Seiji
S
Mawatari
1 Nagasaki University, Nagasaki, Japan.
Eisaku
E
Takahara
1 Nagasaki University, Nagasaki, Japan.
Sizuka
S
Suzuki
1 Nagasaki University, Nagasaki, Japan.
Kenji
K
Hayashida
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001458:Bandages; D047070:Bandages, Hydrocolloid; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012837:Silver Sulfadiazine; D016038:Skin Transplantation; D013411:Sulfadiazine; D014945:Wound Healing
D013411:Sulfadiazine; D012837:Silver Sulfadiazine
donor site wound; quality of wound healing; silver sulfadiazine–impregnated hydrocolloid dressing