Current Perspective of Stem Cell Therapy in Neurodegenerative and Metabolic Diseases.
Neurodegenerative diseases have been an unsolved riddle for quite a while; to date, there are no proper and effective curative treatments and only palliative and symptomatic treatments are available to treat these illnesses. The absence of therapeutic treatments for neurodegenerative ailments has huge economic hit and strain on the society. Pharmacotherapies and various surgical procedures like deep brain stimulation are being given to the patient, but they are only effective for the symptoms and not for the diseases. This paper reviews the recent studies and development of stem cell therapy for neurodegenerative disorders. Stem cell-based treatment is a promising new way to deal with neurodegenerative diseases. Stem cell transplantation can advance useful recuperation by delivering trophic elements that impel survival and recovery of host neurons in animal models and patients with neurodegenerative maladies. Several mechanisms, for example, substitution of lost cells, cell combination, release of neurotrophic factor, proliferation of endogenous stem cell, and transdifferentiation, may clarify positive remedial results. With the current advancements in the stem cell therapies, a new hope for the cure has come out since they have potential to be a cure for the same. This review compiles stem cell therapy recent conceptions in neurodegenerative and neurometabolic diseases and updates in this field. Graphical Absract ᅟ.
Lee Kong Chian School of Medicine, Nanyang Technological University, 59 Nanyang Drive, Singapore, 636921, Singapore.
Ajay
A
Kumar
Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, Singapore, 138669, Singapore. karthikeyan@ibn.a-star.edu.sg.
Karthikeyan
K
Narayanan
School of Biotechnology, Gautam Buddha University, Greater Noida, Uttar Pradesh, 201312, India.
Ravi Kumar
RK
Chaudhary
Lee Kong Chian School of Medicine, Nanyang Technological University, 59 Nanyang Drive, Singapore, 636921, Singapore.
Sachin
S
Mishra
Lee Kong Chian School of Medicine, Nanyang Technological University, 59 Nanyang Drive, Singapore, 636921, Singapore.
Sundramurthy
S
Kumar
National Dental Centre, 11 Lower Kent Ridge Road, Singapore, 119083, Singapore.
Kumar Jayaseelan
KJ
Vinoth
Lee Kong Chian School of Medicine, Nanyang Technological University, 59 Nanyang Drive, Singapore, 636921, Singapore. ppadmanabhan@ntu.edu.sg.
Parasuraman
P
Padmanabhan
Lee Kong Chian School of Medicine, Nanyang Technological University, 59 Nanyang Drive, Singapore, 636921, Singapore. balazs.gulyas@ntu.edu.sg.
Balázs
B
Gulyás
D000818:Animals; D006801:Humans; D008659:Metabolic Diseases / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D019636:Neurodegenerative Diseases / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D033581:Stem Cell Transplantation / Q000379:methods* / Q000639:trends
Alzheimer’s disease; Huntington’s disease; Neurological diseases; Parkinson’s disease; Stem cell therapy