POSS-Containing Bioinspired Adhesives with Enhanced Mechanical and Optical Properties for Biomedical Applications.
A new terpolymer adhesive, poly(2-methoxyethyl acrylate-co-N-methacryloyl 3,4-dihydroxyl-l-phenylalanine-co-heptaisobutyl substituted polyhedral oligomeric silsesquioxane propyl methacrylate) (poly(MEA-co-MDOPA-co-MPOSS) was synthesized by thermally initiated radical polymerization. In this study, we investigated the effect of the POSS component on adhesion, mechanical, and optical properties of the catechol-group containing bioinspired adhesives. The terpolymer contains the catechol group which is known to improve the adhesion properties of polymers. Only a very small amount of the POSS-containing monomer, MPOSS, was included, 0.5 mol %. In the presence of POSS, the synthesized poly(MEA-co-MDOPA-co-MPOSS) demonstrated strong adhesion properties, 23.2 ± 6.2 J/m2with 0.05 N preloading and 300 s holding time, compared to many previously prepared catechol-containing adhesives. The mechanical properties (Young's modulus and stress at 10% strain) of the POSS-containing terpolymer showed significant increases (6-fold higher) over the control polymer, which does not contain POSS. Optical transmittance of the synthesized terpolymer was also improved significantly in the visible light range, 450-750 nm. Cell testing with human embryonic kidney cells (HEK293A) indicates that the new terpolymer is a promising candidate in biomedical adhesives without acute cytotoxicity. The synthesized poly(MEA-co-MDOPA-co-MPOSS) is the first example of POSS-containing pressure sensitive bioinspired adhesive for biomedical applications. The study of poly(MEA-co-MDOPA-co-MPOSS) demonstrated a convenient method to enhance two important properties, mechanical and optical properties, by the addition of a very small amount of POSS. Based on this study, it was found that POSS can be used to strengthen mechanical properties of bioinspired adhesive without the need for a covalent cross-linking step.
Department of Chemical and Biomedical Engineering, Florida State University , Tallahassee, Florida 32310, United States.
Irawan
I
Pramudya
Department of Chemical and Biomedical Engineering, Florida State University , Tallahassee, Florida 32310, United States.
Catalina G
CG
Rico
Department of Biomedical Sciences, Florida State University , Tallahassee, Florida 32306, United States.
Choogon
C
Lee
Department of Chemical and Biomedical Engineering, Florida State University , Tallahassee, Florida 32310, United States.
Hoyong
H
Chung
D000269:Adhesives / Q000737:chemistry*; D049109:Cell Proliferation; D055119:Elastic Modulus; D057809:HEK293 Cells; D006801:Humans; D008422:Materials Testing; D008689:Methacrylates / Q000737:chemistry*; D055620:Optical Phenomena; D017646:Organosilicon Compounds / Q000737:chemistry*; D058105:Polymerization; D011108:Polymers / Q000737:chemistry*; D013314:Stress, Mechanical; D013499:Surface Properties
D000269:Adhesives; D008689:Methacrylates; D017646:Organosilicon Compounds; D011108:Polymers; C503161:polyhedral oligomeric silsesquioxane methacrylate