Evaluation of a framework for the co-registration of intravascular ultrasound and optical coherence tomography coronary artery pullbacks.
A growing number of studies have used a combination of intravascular ultrasound (IVUS) and optical coherence tomography (OCT) for the assessment of atherosclerotic plaques. Given their respective strengths these imaging modalities highly complement each other. Correlations of hemodynamics and coronary artery disease (CAD) have been extensively investigated with both modalities separately, though not concurrently due to challenges in image registration. Manual co-registration of these modalities is a time expensive task subject to human error, and the development of an automatic method has not been previously addressed. We developed a framework that uses dynamic time warping for the longitudinal co-registration and dynamic programming for the circumferential co-registration of images and evaluated the methodology in a cohort (n = 12) of patients with moderate CAD. Excellent correlation was seen between the algorithm and two expert readers for longitudinal co-registration (CCC = 0.9964, CCC = 0.9959) and circumferential co-registration (CCC = 0.9688, CCC = 0.9598). The mean error of the circumferential co-registration angle was found to be within 10%. A framework for the co-registration of IVUS and OCT pullbacks has been developed which provides a foundation for comprehensive studies of CAD biomechanics.
Emory University School of Medicine, Atlanta, GA 30322, USA. Electronic address: dmolony@emory.edu.
David S
DS
Molony
Emory University School of Medicine, Atlanta, GA 30322, USA; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332, USA.
Lucas H
LH
Timmins
Emory University School of Medicine, Atlanta, GA 30322, USA.
Emad
E
Rasoul-Arzrumly
Emory University School of Medicine, Atlanta, GA 30322, USA.
Habib
H
Samady
Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332, USA.
Don P
DP
Giddens
D000465:Algorithms; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D041623:Tomography, Optical Coherence; D018084:Ultrasonography, Interventional
Coronary; Dynamic programming; Hemodynamics; Intravascular imaging