Impact of Young Age at Diagnosis on Survival in Patients with Surgically Treated Renal Cell Carcinoma: a Multicenter Study.
The prognostic significance of age in renal cell carcinoma (RCC) is a subject of debate. The aim of the present multi-institutional study was to evaluate the impact of age on clinicopathological features and survival in a large cohort of patients with RCC. A total of 5,178 patients who underwent surgery for RCC at eight institutions in Korea between 1999 and 2011 were categorized into three groups according to age at diagnosis as follows: young age (< 40 years, n = 541), middle-age (≥ 40 and < 60 years, n = 2,551), and old age (≥ 60 years, n = 2,096) groups. Clinicopathological variables and survival rates were compared between the three groups. Young patients had lower stage tumors with a low Fuhrman grade, a lower rate of lymphovascular invasion than patients in the other age groups. Regarding histologic type, the young age group had a lower percentage of clear cell histology and a greater incidence of Xp11.2 translocation RCC. Kaplan-Meier estimates showed that cancer-specific survival was significantly better in the young age group than in the other groups (log rank test, P = 0.008). However, age at diagnosis was not an independent predictor of survival in multivariate analysis. In conclusion, young age at diagnosis was associated with favorable pathologic features, although it was not an independent prognostic factor for survival in patients with surgically-treated RCC. Age itself should not be regarded as a crucial determinant for the treatment of RCC.
Department of Urology, Chungbuk National University College of Medicine, Cheongju, Korea.
Ho Won
http://orcid.org/0000-0002-8164-4427
HW
Kang
Department of Urology, Chungbuk National University College of Medicine, Cheongju, Korea.
Sung Pil
http://orcid.org/0000-0001-6179-7031
SP
Seo
Department of Urology, Chungbuk National University College of Medicine, Cheongju, Korea.
Won Tae
http://orcid.org/0000-0002-7482-4550
WT
Kim
Department of Urology, Chungbuk National University College of Medicine, Cheongju, Korea.
Seok Joong
http://orcid.org/0000-0001-7737-4746
SJ
Yun
Department of Urology, Chungbuk National University College of Medicine, Cheongju, Korea.
Sang Cheol
http://orcid.org/0000-0002-4163-2210
SC
Lee
Department of Urology, Chungbuk National University College of Medicine, Cheongju, Korea.
Wun Jae
http://orcid.org/0000-0002-8060-8926
WJ
Kim
Department of Urology, Chonnam National University Hwasun Hospital, Hwasun, Korea.
Eu Chang
http://orcid.org/0000-0002-2031-124X
EC
Hwang
Department of Urology, Korea University School of Medicine, Seoul, Korea.
Seok Ho
http://orcid.org/0000-0002-1524-5233
SH
Kang
Department of Urology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Sung Hoo
http://orcid.org/0000-0002-1952-4010
SH
Hong
Department of Urology, National Cancer Center, Goyang, Korea.
Jinsoo
http://orcid.org/0000-0003-2251-5331
J
Chung
Department of Urology, Kyungpook National University College of Medicine, Daegu, Korea.
Tae Gyun
http://orcid.org/0000-0002-4390-0952
TG
Kwon
Department of Urology, Seoul National University College of Medicine, Seoul, Korea.
Hyeon Hoe
http://orcid.org/0000-0001-6600-4539
HH
Kim
Department of Urology, Seoul National University College of Medicine, Seoul, Korea.
Cheol
http://orcid.org/0000-0002-1987-2111
C
Kwak
Department of Urology, Seoul National University Bundang Hospital, Seongnam, Korea.
Seok Soo
http://orcid.org/0000-0001-9356-9500
SS
Byun
Department of Urology, Chungbuk National University College of Medicine, Cheongju, Korea. urokyj@cbnu.ac.kr.
Yong June
http://orcid.org/0000-0001-7638-7174
YJ
Kim
D000328:Adult; D000367:Age Factors; D000368:Aged; D002292:Carcinoma, Renal Cell / Q000175:diagnosis* / Q000401:mortality / Q000601:surgery; D016208:Databases, Factual; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D007680:Kidney Neoplasms / Q000175:diagnosis* / Q000401:mortality / Q000601:surgery; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D009392:Nephrectomy; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies
Age; Nephrectomy; Recurrence; Renal Cell Carcinoma; Survival