Human Parvoviruses.
Parvovirus B19 (B19V) and human bocavirus 1 (HBoV1), members of the large Parvoviridae family, are human pathogens responsible for a variety of diseases. For B19V in particular, host features determine disease manifestations. These viruses are prevalent worldwide and are culturable in vitro, and serological and molecular assays are available but require careful interpretation of results. Additional human parvoviruses, including HBoV2 to -4, human parvovirus 4 (PARV4), and human bufavirus (BuV) are also reviewed. The full spectrum of parvovirus disease in humans has yet to be established. Candidate recombinant B19V vaccines have been developed but may not be commercially feasible. We review relevant features of the molecular and cellular biology of these viruses, and the human immune response that they elicit, which have allowed a deep understanding of pathophysiology.
Department of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, Kansas, USA jqiu@kumc.edu.
Jianming
J
Qiu
Department of Virology, University of Helsinki, Helsinki, Finland.
Maria
M
Söderlund-Venermo
Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.
Neal S
NS
Young
D015967:Gene Expression Regulation, Viral; D016679:Genome, Viral; D056661:Human bocavirus / Q000235:genetics*; D006801:Humans; D010322:Parvoviridae Infections / Q000453:epidemiology* / Q000276:immunology; D016732:Parvovirus B19, Human / Q000235:genetics*; D015995:Prevalence; D014765:Viral Vaccines / Q000627:therapeutic use
D014765:Viral Vaccines
B19 virus; human bocavirus; parvovirus