Effects of Statin Therapy in Patients with Systemic Lupus Erythematosus.
OBJECTIVE
Systemic lupus erythematosus (SLE) is associated with a significant risk of cardiovascular mortality. The use of statins for lipid modulation and the prevention of cardiovascular disease in this population also may impart pleiotropic anti-inflammatory and immunomodulatory effects. Our aim was to identify studies that compared the use of statins and placebo or no statin therapy in patients with SLE.


METHODS
A meta-analysis was conducted on the follow-up measures of serum lipid levels, inflammatory markers, and disease activity, which was measured using the SLE Disease Activity Index (SLEDAI) score. The mean difference (MD) was calculated by the inverse variance method under a fixed or random-effects model, as appropriate.


RESULTS
A total of eight studies met our inclusion criteria, including five randomized controlled trials. The total number of patients was 814 (statins 446, placebo/no statins 368), and follow-up ranged from 1 month to 7 years. The total cholesterol (MD -23.48 mg/dL, 95% confidence interval [CI] -34.57 to -12.39,P< 0.0001), low-density lipoprotein (MD -20.7 mg/dL, 95% CI -30.51 to -10.89,P< 0.0001), and high-sensitivity C-reactive protein (MD -0.40 mg/dL, 95% CI -0.64 to -0.16,P= 0.001) levels were significantly reduced by statin therapy. There was no change with statin use in serum levels of high-density lipoprotein and conventional C-reactive protein, and there was no difference in the SLEDAI score.


CONCLUSIONS
The use of statins in SLE reduced the serum lipid and high-sensitivity C-reactive protein levels, which suggests a role for the primary prevention of cardiovascular disease. Statins did not affect the SLEDAI score, and therefore their use for modifying SLE disease activity levels is not presently supported.
From the Department of Orthopedics and Rheumatology, Cambridge Hospital, Harvard Medical School, Cardiac Ultrasound Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, and the Columbia University Division of Cardiology, Mount Sinai Heart Institute, Miami Beach, Florida.
Rosa T
RT
Artola
From the Department of Orthopedics and Rheumatology, Cambridge Hospital, Harvard Medical School, Cardiac Ultrasound Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, and the Columbia University Division of Cardiology, Mount Sinai Heart Institute, Miami Beach, Florida.
Christos G
CG
Mihos
From the Department of Orthopedics and Rheumatology, Cambridge Hospital, Harvard Medical School, Cardiac Ultrasound Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, and the Columbia University Division of Cardiology, Mount Sinai Heart Institute, Miami Beach, Florida.
Orlando
O
Santana
D002097:C-Reactive Protein / Q000032:analysis; D002318:Cardiovascular Diseases / Q000517:prevention & control*; D002784:Cholesterol / Q000097:blood; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D008077:Lipoproteins, LDL / Q000097:blood; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000188:drug therapy*
D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D008077:Lipoproteins, LDL; D002097:C-Reactive Protein; D002784:Cholesterol