Systemic matrix metalloproteinase-8 response in chronic tonsillitis.
The development of several life-long diseases, such as coronary heart disease, is affected by low-grade systemic inflammation. Data on the potential long-term health effects of chronic tonsillitis are limited. Many inflammatory conditions present with enhanced systemic matrix metalloproteinase (MMP)-8 response. In head and neck cancer, high plasma level of tissue inhibitor of metalloproteinase (TIMP)-1 predicts poor prognosis. We analyzed S-MMP-8 with immunofluorometric assay and S-TIMP-1 with an immunosorbent assay in 175 consecutive patients undergoing tonsillectomy for benign tonsillar disease, and in 33 control patients with tonsillar squamous cell carcinoma. Tonsillar human papillomavirus (HPV) status was determined by PCR. In patients with benign tonsillar disease, chronic tonsillitis without hypertrophy was associated with enhanced systemic MMP-8 response. Compared to patients with benign tonsillar disease, patients with tonsillar squamous cell carcinoma had significantly higher concentrations of S-MMP-8 and S-TIMP-1. Neither S-MMP-8 nor S-TIMP-1 correlated with tonsillar HPV positivity.
a Department of Otorhinolaryngology - Head and Neck Surgery , University of Helsinki and Helsinki University Hospital , Helsinki , Finland.
Taru
T
Ilmarinen
a Department of Otorhinolaryngology - Head and Neck Surgery , University of Helsinki and Helsinki University Hospital , Helsinki , Finland.
Triin
T
Lont
b Department of Pathology , University of Helsinki and Helsinki University Hospital , Helsinki , Finland.|c Research Programs Unit, Translational Cancer Biology , University of Helsinki , Helsinki , Finland.
Jaana
J
Hagström
d Department of Oral and Maxillofacial Diseases , University of Helsinki , Helsinki , Finland.
Taina
T
Tervahartiala
d Department of Oral and Maxillofacial Diseases , University of Helsinki , Helsinki , Finland.|e Department of Dental Medicine , Karolinska Institutet and Karolinska University Hospital , Huddinge and Stockholm , Sweden.
Timo
T
Sorsa
c Research Programs Unit, Translational Cancer Biology , University of Helsinki , Helsinki , Finland.|f Department of Surgery and Pathology , University of Helsinki and Helsinki University Hospital , Helsinki , Finland.
Caj
C
Haglund
g Department of Clinical Science, Intervention Technology, Division of ENT Diseases , Karolinska Institutet , Stockholm , Sweden.
Eva
E
Munck-Wickland
h Department of Oncology-Pathology , Karolinska Institutet, Cancer Center Karolinska R8:01, Karolinska University Hospital , Stockholm , Sweden.
Torbjörn
T
Ramqvist
h Department of Oncology-Pathology , Karolinska Institutet, Cancer Center Karolinska R8:01, Karolinska University Hospital , Stockholm , Sweden.
Tina
T
Dalianis
a Department of Otorhinolaryngology - Head and Neck Surgery , University of Helsinki and Helsinki University Hospital , Helsinki , Finland.
Leena-Maija
LM
Aaltonen
D000293:Adolescent; D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D005260:Female; D015200:Fluoroimmunoassay; D006801:Humans; D007163:Immunosorbent Techniques; D007223:Infant; D008297:Male; D020784:Matrix Metalloproteinase 8 / Q000097:blood*; D008875:Middle Aged; D030361:Papillomavirus Infections / Q000473:pathology; D019715:Tissue Inhibitor of Metalloproteinase-1 / Q000097:blood; D014067:Tonsillar Neoplasms / Q000473:pathology; D014069:Tonsillitis / Q000473:pathology*; D055815:Young Adult
C560822:TIMP1 protein, human; D019715:Tissue Inhibitor of Metalloproteinase-1; D020784:Matrix Metalloproteinase 8
HPV; Head and neck cancer; MMP-8; TIMP-1; tonsillitis