Successful treatment of a child with a prolactin secreting macroadenoma with temozolomide.
Prolactinomas are a rare subset of brain tumors in pediatrics. We report a child with a prolactin secreting macroadenoma which was refractory to initial treatment with a dopamine antagonist. Given the location of her tumor she was ineligible for surgical resection. Temozolomide (200 mg/m2×5 days each month) was administered with a dramatic and prolonged response in tumor size, prolactin level, and symptoms, with no side effects from treatment. We demonstrate the benefit of temozolomide in the treatment of a pediatric patient with prolactinoma.
James
http://orcid.org/0000-0003-4585-8126
J
Felker
Brianna
B
Patterson
David
D
Wrubel
Anna
A
Janss
D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use; D002648:Child; D003606:Dacarbazine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D010911:Pituitary Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D011379:Prognosis; D011388:Prolactin / Q000378:metabolism*; D015175:Prolactinoma / Q000188:drug therapy* / Q000378:metabolism; D000077204:Temozolomide
D018906:Antineoplastic Agents, Alkylating; D003606:Dacarbazine; D011388:Prolactin; D000077204:Temozolomide