Postoperative changes in high mobility group box 1 levels after colorectal cancer surgery.
Objective To investigate the potential use of high mobility group box 1 (HMGB1) as a marker for the surgical course following surgery for colorectal cancer (CRC). Methods Patients with advanced CRC undergoing open colorectal surgery who did not develop postsurgical complications were enrolled in the study. Blood samples were taken preoperatively and at 1 day, 1 week and 3 weeks after surgery for the measurement of the white blood cell count, serum C-reactive protein, serum amyloid A and HMGB1. Results Data from 21 patients were analysed. HMGB1 levels changed significantly during the surgical course, increasing from a preoperative median of 6.8 ng/ml to 12.1 ng/ml at 1 day postoperatively, and then decreasing to 8.1 ng/ml at 1 week postoperatively and 4.0 ng/ml at 3 weeks postoperatively. These changes were similar to but were not completely correlated with the changes seen in the other markers. Conclusion Serum HMGB1 may be a potential marker to monitor the surgical course in patients undergoing surgery for CRC, although further studies are warranted before it can be introduced into routine clinical practice.
1 Department of Anaesthesiology and Critical Care Medicine, Jichi Medical University, Tochigi, Japan.
Masaaki
M
Satoh
2 Division of Community and Family Medicine, Jichi Medical University, Tochigi, Japan.
Kazuhiko
K
Kotani
3 Central Laboratory, Shino-Test Corporation, Kanagawa, Japan.
Shingo
S
Yamada
4 Department of Surgery, Jichi Medical University, Tochigi, Japan.
Koji
K
Koinuma
4 Department of Surgery, Jichi Medical University, Tochigi, Japan.
Hisanaga
H
Horie
1 Department of Anaesthesiology and Critical Care Medicine, Jichi Medical University, Tochigi, Japan.
Mamoru
M
Takeuchi
D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood; D015179:Colorectal Neoplasms / Q000097:blood*; D003107:Colorectal Surgery; D005260:Female; D024243:HMGB1 Protein / Q000097:blood*; D006801:Humans; D008297:Male; D011182:Postoperative Care
D014408:Biomarkers, Tumor; D024243:HMGB1 Protein
C-reactive protein; Cancer; colorectal surgery; high mobility group box 1; serum amyloid A; white blood cell count