Metabolomics in pancreatic cancer biomarkers research.
Pancreatic cancer is one of the worst prognoses of all malignancies. More than 40,000 deaths a year from this disease are observed in European Union alone. The only possibly curative treatment of pancreatic cancer is surgery, yet only 15-20% of patients have operable disease and even patients, which go through surgery and adjuvant chemotherapy, survival is less than 30%. The sensitive and specific biomarkers which could be used for the advance of early diagnostics are needed and constantly researched. Metabolomics is a technology which analyzes the concentrations of low-molecular-weight metabolites (the metabolome) has lately effectively developed due to the improvements in analytical technology. Metabolome analysis can be a one of the useful approaches for the biomarker discovery and disease diagnosis. Here we discuss recent discoveries in the field of pancreatic cancer metabolomics as well as the most promising biomarkers for diagnostics, prognosis and prediction.
Center of Abdominal Surgery, Vilnius University Hospital, Santariskiu Klinikos Santariskiu str. 2, 08661, Vilnius, Lithuania.
Jaroslav
J
Tumas
Institute of Biotechnology, Vilnius University, Saulėtekio ave. 7, 01222, Vilnius, Lithuania.
Kotryna
K
Kvederaviciute
Center of Abdominal Surgery, Vilnius University Hospital, Santariskiu Klinikos Santariskiu str. 2, 08661, Vilnius, Lithuania.
Marius
M
Petrulionis
Center of Hepatology, Gastroenterology and Dietology, Vilnius University Hospital, Santariskiu Klinikos Santariskiu str. 2, 08661, Vilnius, Lithuania.
Benediktas
B
Kurlinkus
Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
Arnas
A
Rimkus
Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
Greta
G
Sakalauskaite
Vetsuisse Faculty, Institute of Animal Pathology, University of Bern, 3012, Bern, Switzerland. j.cicenas@mapkinases.eu.|MAP Kinase Resource, Bioinformatics, Melchiorstrasse 9, 3027, Bern, Switzerland. j.cicenas@mapkinases.eu.|Proteomics Centre, Institute of Biochemistry, Vilnius University, 08662, Vilnius, Lithuania. j.cicenas@mapkinases.eu.
Jonas
http://orcid.org/0000-0002-9365-1843
J
Cicenas
Center of Abdominal Surgery, Vilnius University Hospital, Santariskiu Klinikos Santariskiu str. 2, 08661, Vilnius, Lithuania. audrius.sileikis@santa.lt.|Center of Hepatology, Gastroenterology and Dietology, Vilnius University Hospital, Santariskiu Klinikos Santariskiu str. 2, 08661, Vilnius, Lithuania. audrius.sileikis@santa.lt.
Audrius
A
Sileikis
D000818:Animals; D014408:Biomarkers, Tumor / Q000378:metabolism*; D006801:Humans; D055432:Metabolomics / Q000379:methods; D010190:Pancreatic Neoplasms / Q000378:metabolism*
D014408:Biomarkers, Tumor
Biomarkers; Metabolome; Metabolomics; Pancreatic cancer