Management of Sitagliptin and Metformin Combination Toxic Overdose.
Metformin and Sitagliptin are often used in combination in the management of non-insulin dependent diabetes mellitus. Though toxicity is rare, but occurs more frequently in cases of intentional or unintentional overdose of these drugs. Here, we present a case of an intentional overdose of a metformin- sitagliptin combination (70g metformin and 3500mg sitagliptin) in a suicide attempt by a young non-diabetic female who presented with severe lactic acidosis and was successfully treated with prompt hemodialysis and bicarbonate therapy.
Sr. Consultant and Head, Dept of Internal Medicine.
Sudhish
S
Sehra
Consultant Diabetologist and Incharge, Action Diabetes Clinic, Sri Balaji Action Medical Institute, New Delhi.
Shalini
S
Jaggi
Sr. Consultant and Diabetotlogist, Dept of Internal Medicine, Param Tej Sehra Medical Centre, New Delhi.
Devindra
D
Sehra
Sr. Consultant and Head, Dept. of Nephrology.
Rajesh
R
Aggarwal
Junior Consultant.
Vikas
V
Saraswat
Senior Consultant and Co-ordinator, Dept. of Critical Care and Emergency Medicine, Sri Balaji Action Medical Institute, New Delhi.
Deven
D
Juneja
D000140:Acidosis, Lactic / Q000139:chemically induced*; D000328:Adult; D062787:Drug Overdose / Q000150:complications*; D005260:Female; D006801:Humans; D008687:Metformin / Q000506:poisoning*; D000068900:Sitagliptin Phosphate / Q000506:poisoning*; D013406:Suicide, Attempted
D008687:Metformin; D000068900:Sitagliptin Phosphate