F-THENA: a chiral derivatizing agent for the determination of the absolute configuration of secondary aromatic alcohols with a self-validating system.
F-THENA is designed as an alternative fluorine-containing chiral derivatizing agent (CDA). The fluorine atom functions exclusively as a reporter which can directly sense an anisotropic effect from an aromatic substituent of a chiral alcohol. In combination with chemical shift differences from both19F NMR and1H NMR, the F-THENA method can successfully be used for determining the absolute configuration of chiral secondary aromatic alcohols with a self-validating system.
Department of Chemistry and Center of Excellence for Innovation in Chemistry (PERCH-CIC), Faculty of Science, Mahidol University, Rama 6 Road, Bangkok 10400, Thailand. tienthong.tho@mahidol.ac.th.
Kulvadee
K
Dolsophon
Department of Chemistry and Center of Excellence for Innovation in Chemistry (PERCH-CIC), Faculty of Science, Mahidol University, Rama 6 Road, Bangkok 10400, Thailand. tienthong.tho@mahidol.ac.th.
Jakapun
J
Soponpong
National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Thailand Science Park, Phathumthani 12120, Thailand.
Jittra
J
Kornsakulkarn
National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Thailand Science Park, Phathumthani 12120, Thailand.
Chawanee
C
Thongpanchang
Department of Chemistry and Center of Excellence for Innovation in Chemistry (PERCH-CIC), Faculty of Science, Mahidol University, Rama 6 Road, Bangkok 10400, Thailand. tienthong.tho@mahidol.ac.th.
Samran
S
Prabpai
Department of Chemistry and Center of Excellence for Innovation in Chemistry (PERCH-CIC), Faculty of Science, Mahidol University, Rama 6 Road, Bangkok 10400, Thailand. tienthong.tho@mahidol.ac.th.
Palangpon
http://orcid.org/0000-0003-2689-9651
P
Kongsaeree
Department of Chemistry and Center of Excellence for Innovation in Chemistry (PERCH-CIC), Faculty of Science, Mahidol University, Rama 6 Road, Bangkok 10400, Thailand. tienthong.tho@mahidol.ac.th and National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Thailand Science Park, Phathumthani 12120, Thailand.
Tienthong
T
Thongpanchang