Comparison of acute phase reaction and postoperative stress in pigs undergoing video-assisted thoracoscopic versus thoracotomy pneumonectomy.
BACKGROUND
Video-assisted thoracoscopic surgery (VATS) has been used for many thoracic diseases as an alternate approach to thoracotomy. The aim of this study was to compare the surgical outcome of pneumonectomy using VATS with that using thoracotomy pneumonectomy in pigs. Fourteen pigs were equally divided into two groups; one group underwent VATS and the other group underwent transthoracic pneumonectomy. We monitored pre-, intra-, and post-operative physiologic parameters, along with blood cell count, serum C-reactive protein (CRP), serum amyloid A (SAA), interleukin-6 (IL-6) and cortisol. The differences between the two approaches were analyzed.


RESULTS
Mean surgical time in the VATS group (160.6 ± 16.2 min) was significantly longer than that in the thoracotomy group (123.7 ± 13.2 min). In both groups, CRP and IL-6 concentrations were significantly increased at postoperative 4 h, and then gradually decreased to preoperative levels. CRP and IL-6 at postoperative day 1 were significant lower in the VATS group compared with the thoracotomy group. SAA was significantly increased at postoperative days 1 and 3 in both groups compared with preoperative levels. Cortisol was significantly increased immediately after surgery in both groups compared with preoperative levels, and was significantly higher in the thoracotomy group than the VATS group at postoperative 4 h and 1 day.


CONCLUSIONS
There was no difference between the two groups in physiologic parameters and blood cell count. However, the results indicate that VATS resulted in a smaller incision, less acute-phase reaction, less stress and less pain compared with thoracotomy pneumonectomy.
Department of Veterinary Surgery, College of Veterinary Medicine, Northeast Agricultural University, No. 59 Mucai Street, Gongbin Road, Xiangfang District, Harbin, 150030, People's Republic of China.
Hai-Feng
HF
Liu
Department of Veterinary Surgery, College of Veterinary Medicine, Northeast Agricultural University, No. 59 Mucai Street, Gongbin Road, Xiangfang District, Harbin, 150030, People's Republic of China.
Li
L
Gao
Department of Veterinary Surgery, College of Veterinary Medicine, Northeast Agricultural University, No. 59 Mucai Street, Gongbin Road, Xiangfang District, Harbin, 150030, People's Republic of China.
Tao
T
Liu
College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, People's Republic of China.
Yan-Jiang
Department of Veterinary Surgery, College of Veterinary Medicine, Northeast Agricultural University, No. 59 Mucai Street, Gongbin Road, Xiangfang District, Harbin, 150030, People's Republic of China. hbwang1940@163.com.
Hong-Bin
HB
Wang
D000210:Acute-Phase Reaction / Q000097:blood / Q000662:veterinary*; D000818:Animals; D001774:Blood Chemical Analysis / Q000662:veterinary; D011013:Pneumonectomy / Q000592:standards / Q000662:veterinary*; D011184:Postoperative Period; D013312:Stress, Physiological / Q000502:physiology*; D013552:Swine; D013553:Swine Diseases / Q000601:surgery*; D020775:Thoracic Surgery, Video-Assisted / Q000592:standards / Q000662:veterinary*; D013908:Thoracotomy / Q000592:standards / Q000662:veterinary*
Acute-phase reaction; Body stress; Pneumonectomy; Postoperative pain; VATS