Quercetin attenuates, indomethacin-induced acute gastric ulcer in rats.
Peptic ulcer diseases are common and are induced by many factors, including stress, smoking, and ingestion of non-steroidal anti-inflammatory drugs. Quercetin is considered to be an anti-oxidant with healing effects on many experimental toxic injuries. The present study aimed to explore the possible effect of quercetin on acute gastric ulcer induced by indomethacin in rats.



Three groups received indomethacin (30 mg/kg body weight) orally by orogastric gavage on two consecutive days. The rats received famotidine (50 mg/kg body weight), quercetin (50 mg/kg body weight), or vehicle alone for 15 consecutive days by oral gavage. The control group received no indomethacin but received vehicle for 15 days by oral gavage. The ulcer index, volume, and pH of gastric juice were measured, and the stomachs were examined by routine light microscopy.



Compared with the control group, the indomethacin-treated rats showed a marked damage of the gastric mucosal surface and a high ulcer index. In the famotidine- and quercetin-treated groups, significantly increased antioxidant enzyme activities were observed. The congestion, erosions, and necrosis were reduced with mild inflammatory cell infiltration while no major damage of endothelial cells was observed in the treated rats.



The findings of the study show that quercetin had antioxidant effect and can protect gastric mucosa against indomethacin-induced gastric ulceration than famotidine.
Department of Anatomy, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia, Saudi Arabia. dr.alkushi@gmail.com.
A G R
AGR
Alkushi
N A M
NAM
Elsawy
D000208:Acute Disease; D000818:Animals; D005748:Gastric Fundus / Q000187:drug effects / Q000473:pathology; D005753:Gastric Mucosa / Q000187:drug effects; D005978:Glutathione / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D007213:Indomethacin; D008297:Male; D011794:Quercetin / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D013276:Stomach Ulcer / Q000139:chemically induced* / Q000188:drug therapy*
D011794:Quercetin; D005978:Glutathione; D007213:Indomethacin
flavonoids; gastric juice; nonsteroidal anti-inflammatory drugs; pH value; ulceration