Genetic Polymorphism of Angiotensin-Converting Enzyme and Chronic Obstructive Pulmonary Disease Risk: An Updated Meta-Analysis.
The relationship between polymorphism of the angiotensin I converting enzyme (ACE) gene and chronic obstructive pulmonary disease (COPD) has been examined in many previous studies. However, their results were controversial. Therefore, we performed a meta-analysis to evaluate the relationship between theACEgene and the risk of COPD. Fourteen case-control studies were included in this meta-analysis. The pooledpvalue, odds ratio (OR), and 95% confidence interval (95% CI) were used to investigate the strength of the association. The meta-analysis was performed using comprehensive meta-analysis software. Our meta-analysis results revealed that ACE polymorphisms were not related to the risk of COPD (p> 0.05 in each model). In further analyses based on ethnicity, we observed an association between insertion/deletion polymorphism of theACEgene and risk of COPD in the Asian population (codominant 2, OR = 3.126, 95% CI = 1.919-5.093,p< 0.001; recessive, OR = 3.326, 95% CI = 2.190-5.050,p< 0.001) but not in the Caucasian population (p> 0.05 in each model). In conclusion, the present meta-analysis indicated that the insertion/deletion polymorphism of theACEgene may be associated with susceptibility to COPD in the Asian population but not in the Caucasian population. However, the results of the present meta-analysis need to be confirmed in a larger sample.
Department of Dental Pharmacology, School of Dentistry, Dankook University, Cheonan 31116, Republic of Korea.
Sang Wook
SW
Kang
Kohwang Medical Research Institute, School of Medicine, Kyung Hee University, Seoul 02447, Republic of Korea.
Su Kang
SK
Kim
Kohwang Medical Research Institute, School of Medicine, Kyung Hee University, Seoul 02447, Republic of Korea.
Joo-Ho
0000-0003-3517-7175
JH
Chung
Division of Allergy and Respiratory System, Department of Korean Internal Medicine, College of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of Korea.
Hee-Jae
HJ
Jung
Division of Allergy and Respiratory System, Department of Korean Internal Medicine, College of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of Korea.
Kwan-Il
KI
Kim
Department of Korean Physiology, College of Pharmacy, Kyung Hee University, Seoul 02447, Republic of Korea.
Jinju
J
Kim
Department of Dental Pharmacology, School of Dentistry, Dankook University, Cheonan 31116, Republic of Korea.
Ju Yeon
0000-0003-1992-5188
JY
Ban
D044466:Asian People / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000208:ethnology*; D006801:Humans; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D029424:Pulmonary Disease, Chronic Obstructive / Q000201:enzymology / Q000208:ethnology* / Q000235:genetics*; D012307:Risk Factors; D044465:White People
C488034:ACE protein, human; D007703:Peptidyl-Dipeptidase A