Correlations Between Serum Apolipoprotein A-I and Formation of Vocal Cord Polyp.
OBJECTIVE
This study aims to investigate the correlations between serum apolipoprotein A-I (ApoA-I) and the formation of vocal cord polyps (VCPs).


METHODS
This study used the nonmatched case-control study method.


METHODS
The serum total cholesterol (TC), triglyceride, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol, ApoA-I, apolipoprotein B (ApoB), and ApoA-I/ApoB levels of 89 VCP patients and 87 normal volunteers were compared. Additionally, such VCP-related factors as excessive vocal use, vocal abuse, smoking, drinking, and the size of VCPs were analyzed.


RESULTS
The two groups did not significantly differ with regard to triglyceride, low-density lipoprotein cholesterol, ApoB, and ApoA-I/ApoB levels (P > 0.05), whereas they did significantly differ with regard to TC, HDL-C, and ApoA-I levels (P < 0.05) according to independent t tests. Logistic regression analysis showed that excessive vocal use and vocal abuse were risk factors for VCPs (P < 0.05), with odds ratio values of 5.675 and 12.781, respectively. The ApoA-I level was negatively associated with VCPs (P < 0.05), with an odds ratio of 0.511; however, TC and HDL-C were not associated with the formation of VCPs (P > 0.05). The size of VCPs in females was negatively correlated with the serum ApoA-I level (r = -0.349, P = 0.032), whereas that in males was not (P > 0.05).


CONCLUSIONS
As the serum ApoA-I level was negatively correlated with the formation of VCPs, ApoA-I may reduce the risk of VCPs. These findings may facilitate the prevention and treatment of VCPs.
Department of Otolaryngology and Head-Neck Surgery, the First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China.
Hui-Ping
HP
Zhang
Department of Otolaryngology and Head-Neck Surgery, the First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China. Electronic address: zhang2012rong@sina.cn.
Rong
R
Zhang
D000328:Adult; D000368:Aged; D016632:Apolipoprotein A-I / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D007818:Laryngeal Diseases / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology / Q000517:prevention & control; D007828:Laryngoscopy; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D011127:Polyps / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology; D065840:Protective Factors; D012307:Risk Factors; D014827:Vocal Cords / Q000503:physiopathology; D014833:Voice Quality; D055815:Young Adult
C505693:APOA1 protein, human; D016632:Apolipoprotein A-I; D015415:Biomarkers
Apolipoprotein A-I; Blood lipids; Risk factors; Size of vocal cord polyps; Vocal cord polyps