The balancing roles of mechanical forces during left-right patterning and asymmetric morphogenesis.
Left-right patterning and asymmetric morphogenesis arise from a complex set of molecular and cellular interactions that are particularly dynamic and associated with mechanical forces. How do mechanical forces translate into tissular asymmetries? Are these forces asymmetrical de novo, or do they build up from pre-existing asymmetries? Advances in developmental genetics, live imaging and cell biology have recently shed light on the origins of mechanical forces generated at the cell scale and their implication in asymmetric patterning and morphogenesis is now emerging. Here we ask when and how, molecular asymmetries and mechanical forces contribute to left-right patterning and organ asymmetries.
Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France; Centre National de la Recherche Scientifique, UMR7104, Illkirch, France; Institut National de la Santé et de la Recherche Médicale, U964, Illkirch, France; Université de Strasbourg, Illkirch, France.
Rita R
RR
Ferreira
Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France; Centre National de la Recherche Scientifique, UMR7104, Illkirch, France; Institut National de la Santé et de la Recherche Médicale, U964, Illkirch, France; Université de Strasbourg, Illkirch, France. Electronic address: julien@igbmc.fr.
Julien
J
Vermot
D000205:Actomyosin / Q000235:genetics* / Q000378:metabolism; D000818:Animals; D001696:Biomechanical Phenomena; D019521:Body Patterning / Q000235:genetics*; D002448:Cell Adhesion; D002454:Cell Differentiation; D002465:Cell Movement; D016764:Cell Polarity / Q000235:genetics*; D002642:Chick Embryo; D002645:Chickens; D002923:Cilia / Q000378:metabolism; D004622:Embryo, Mammalian; D004625:Embryo, Nonmammalian; D018507:Gene Expression Regulation, Developmental; D040542:Mechanotransduction, Cellular; D051379:Mice; D015027:Zebrafish / Q000196:embryology
D000205:Actomyosin