Only Time Will Tell: The Future of Donation After Circulatory Death.
The rapid rise of transplantation over the past 60 years has been marked by a number of critical milestones. Donation after circulatory death (DCD) has played an important role in the development of this young field. Although early observations by Dr. Tom Starzl touched on the importance of warm ischemic time, new and exciting data may be changing our views of ischemia. Indeed, as we learn more about the importance of time-to-death for DCD donors after circulatory death, the hemodynamic changes experienced by DCD donors, and the other physiologic perturbations surrounding all forms of death, we are beginning to drill down to the factors that drive recipient outcomes after deceased donor transplant. As far as the future? Only time will tell.
From the Division of Transplantation, Department of Surgery, University of Wisconsin, Madison, Wisconsin, USA.
Joseph R
JR
Scalea
Hans W
HW
Sollinger
D002423:Cause of Death; D004059:Diffusion of Innovation; D046148:Donor Selection; D005544:Forecasting; D006084:Graft Rejection / Q000276:immunology / Q000517:prevention & control; D006085:Graft Survival; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D016377:Organ Transplantation / Q000009:adverse effects / Q000266:history / Q000639:trends*; D012307:Risk Factors; D013997:Time Factors; D014019:Tissue Donors / Q000266:history / Q000600:supply & distribution*; D009927:Tissue and Organ Procurement / Q000266:history / Q000639:trends*; D016896:Treatment Outcome