Prevalence and Characteristics of Cavum Septum Pellucidum in Schizophrenia: A 16 Slice Computed Tomography Study.
OBJECTIVE
Several significant midline abnormalities including cavum septum pellucidum (CSP) have been reported in schizophrenia. However, not all studies were able to replicate similar findings. Furthermore, very few of them were conducted with large samples.


METHODS
CSP was identified and graded with 16 slice computed tomography (CT) machine in 138 patients of schizophrenia and 64 controls.


RESULTS
We found 21.0% of patients in schizophrenia group had abnormal CSP compared to only 9.4% in control group (P= 0.047). Grade III was most frequent type (19.6%) in schizophrenia group.


CONCLUSIONS
Our study adds to the existing literature suggesting abnormal CSP may reflect neurodevelopmental process in schizophrenia. The strength of our study was larger sample size. Limitations were use of CT, male predominance in schizophrenia group, the inclusion of nonpsychiatric patients in control group.
Department of Psychiatry, Central Institute of Psychiatry, Ranchi, Jharkhand, India.
Sourav
S
Khanra
Department of Psychiatry, Central Institute of Psychiatry, Ranchi, Jharkhand, India.
Naveen Kumar
NK
Srivastava
Center for Neuroimaging and Radio Diagnosis, Central Institute of Psychiatry, Ranchi, Jharkhand, India.
Vivek
V
Chail
Department of Psychiatry, Central Institute of Psychiatry, Ranchi, Jharkhand, India.
Christoday Raja Jayant
CR
Khess
Cavum septum pellucidum; characteristics; computed tomography; neuroimaging; prevalence; schizophrenia