Getting a gRIP on Flu by Casting the DAI.
Influenza A initiates host cell death through unknown mechanisms. Thapa et al. (2016) in this issue of Cell Host & Microbe, along with recent work by Kuriakose et al. (2016), indicate that this virus provokes divergent modes of cell death, including apoptosis and necroptosis, via the nucleic acid sensor, DAI.
Molecular Cell Biology Laboratory, Department of Genetics, The Smurfit Institute, Trinity College, Dublin 2, Ireland.
Danielle M
DM
Clancy
Molecular Cell Biology Laboratory, Department of Genetics, The Smurfit Institute, Trinity College, Dublin 2, Ireland. Electronic address: martinsj@tcd.ie.
Seamus J
SJ
Martin
D017209:Apoptosis; D016923:Cell Death; D009980:Influenza A virus; D009336:Necrosis