Novel Nanoprinting for Oral Delivery of Poorly Soluble Drugs.
Many of the newly developed drugs for cancer, and some of those for cardiovascular disease, are poorly soluble in water and cannot be taken orally. This can be overcome by employing a new and effective delivery system utilizing nanotechnology. We present a new method for oral preparation of poorly soluble drugs that entails assembling (printing) drug-loaded polymeric micelles into sub-100 nm orally acceptable nanorods (NRs). Due to their small size, these NRs will have a high permeability through cells and thus should transport through the intestine to allow for drug delivery in the blood. These NRs drugs are expected to penetrate tumors more efficiently and much faster than individual nanoparticles and may also be useful for drug delivery to atherosclerotic plaque. This should lead to better bioavailability of the drug with reduced toxicity and side effects. Currently used micellar formulations are administered intravenously, which is invasive and could be toxic due to high doses and interaction with normal healthy tissues. Oral drug administration is the easiest and most desirable way to deliver most drugs, including those that are poorly soluble.
Northeastern University, Boston Massachusetts.
Cihan
C
Yilmaz
Northeastern University, Boston Massachusetts.
Can
C
Sarisozen
Northeastern University, Boston Massachusetts.
Vladimir
V
Torchilin
Northeastern University, Boston Massachusetts.
Ahmed
A
Busnaina
D000284:Administration, Oral; D000818:Animals; D002318:Cardiovascular Diseases / Q000188:drug therapy*; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D016503:Drug Delivery Systems; D006801:Humans; D008823:Micelles; D053758:Nanoparticles; D036103:Nanotechnology / Q000379:methods*; D009369:Neoplasms / Q000188:drug therapy*; D010316:Particle Size
D008823:Micelles
drug-loaded micelles; nanoparticles; nanorods; poorly soluble drugs