Hepatocyte Transplantation in Special Populations: Clinical Use in Children.
Orthotopic liver transplantation remains the only proven cure for end-stage liver failure. Despite significant advances in the field, the clinical demand for donor organs far outweighs the supply. Hepatocyte transplantation has been proposed as an alternative approach to whole liver transplant in select diseases. Several international centers have reported experimental trials of human hepatocyte transplantation in acute liver failure and liver-based metabolic disorders. This chapter provides an introduction to hepatocyte transplantation from both a technical and clinical perspective. We will also focus on the special needs of pediatric patients, since historically the majority of clinical hepatocyte transplants have involved infants and children.
Department of Pediatric Gastroenterology and Pathology, Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA. zahida.khan@chp.edu.|McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA. zahida.khan@chp.edu.
Zahida
Z
Khan
Division of Pathology, Department of Laboratory Medicine, Cell Transplantation and Regenerative Medicine, Karolinska Institutet, Stockholm, Sweden.
Stephen C
SC
Strom
D000293:Adolescent; D017690:Cell Transplantation / Q000009:adverse effects / Q000379:methods*; D002648:Child; D002675:Child, Preschool; D058625:End Stage Liver Disease / Q000601:surgery*; D022781:Hepatocytes / Q000637:transplantation*; D006801:Humans; D007223:Infant; D017114:Liver Failure, Acute / Q000601:surgery*; D016031:Liver Transplantation / Q000379:methods* / Q000639:trends
Cell therapy; Gene therapy; Hepatocyte transplant; Human hepatocytes; Metabolic liver disease; Pediatric liver disease; Regenerative medicine