Development and Validation of the Korean Version of Hand-Foot Skin Reaction and Quality of Life Questionnaire (HF-QoL-K).
Given the growing number of cancer patients and the resulting increase in the administration of chemotherapeutic agents, convenient and effective methods for measuring the symptoms and quality of life associated with the hand-foot syndrome (HFS) are needed. Therefore, the aim of this study was to develop and validate the Korean version of the hand-foot skin reaction and quality of life questionnaire (HF-QoL-K), comprising a 20-item symptom domain and an 18-item daily activity domain. After we developed the HF-QoL-K, 209 Korean patients with gynecologic cancer who were undergoing chemotherapeutic agents relating the HFS were asked to fill in the questionnaire. The content validity, internal consistency reliability, and test-retest reliability were evaluated. The internal validity index, Cronbach's alpha coefficient, and intra-class correlation coefficient of the HF-QoL-K were 0.90, 0.958, and 0.825 (95% confidence interval [CI], 0.774-0.865), respectively. The scatter plot (Pearson correlation coefficient, 0.826) and the Bland-Altman plot for test-retest reliability were also acceptable. The HF-QoL-K instrument is a valid and reliable questionnaire for the measurement of the symptoms and quality of life in Korean cancer patients suffering HFS.
Department of Obstetrics and Gynecology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
Se Hyun
http://orcid.org/0000-0001-6438-3555
SH
Nam
Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Hyun Jin
http://orcid.org/0000-0003-4058-9094
HJ
Choi
Department of Obstetrics and Gynecology, Chonnam National University Hwasun Hospital, Chonnam National University Medical School, Hwasun, Korea.
Woo Dae
http://orcid.org/0000-0002-3952-9724
WD
Kang
Department of Obstetrics and Gynecology, Chonnam National University Hwasun Hospital, Chonnam National University Medical School, Hwasun, Korea.
Seok Mo
http://orcid.org/0000-0003-2318-0334
SM
Kim
Gynecologic Cancer Branch and Center for Uterine Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Korea.
Myong Cheol
http://orcid.org/0000-0001-8964-7158
MC
Lim
Gynecologic Cancer Branch and Center for Uterine Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Korea.
Sang Yoon
http://orcid.org/0000-0001-8325-6009
SY
Park
Korean Language and Literature, Kyung Hee University, Seoul, Korea.
Jung Sup
http://orcid.org/0000-0003-1660-8419
JS
Kim
Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Byoung Gie
http://orcid.org/0000-0002-0572-8450
BG
Kim
Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Duk Soo
http://orcid.org/0000-0003-0016-1704
DS
Bae
Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Jeong Won
http://orcid.org/0000-0002-6945-0398
JW
Lee
Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Tae Joong
http://orcid.org/0000-0002-9693-9164
TJ
Kim
Department of Obstetrics and Gynecology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea. taejong.song@gmail.com.
Taejong
http://orcid.org/0000-0003-0288-1254
T
Song
D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use; D015992:Body Mass Index; D005260:Female; D005833:Genital Neoplasms, Female / Q000188:drug therapy; D060831:Hand-Foot Syndrome / Q000175:diagnosis* / Q000209:etiology; D006801:Humans; D008875:Middle Aged; D011788:Quality of Life; D015203:Reproducibility of Results; D056910:Republic of Korea; D011795:Surveys and Questionnaires; D014177:Translations
D000970:Antineoplastic Agents
Chemotherapy; Gynecologic Cancer; Hand-Foot Syndrome; Quality of Life; Questionnaires; Validation