Cardiogenic shock: Inotropes and vasopressors.
Cardiogenic shock is characterized by a decrease in myocardial contractility, and presents a high mortality rate. Inotropic and vasopressor agents have been recommended and used for several years in the treatment of patients in shock, but they remain controversial. Despite its beneficial effect on myocardial contractility, the side effects of inotropic therapy (arrhythmias and increased myocardial oxygen consumption) may be associated with increased mortality. The pharmacodynamics of different inotropic agents suggest benefits in specific situations, but these differences have not been reflected in reduced mortality in most studies, making it difficult to formulate recommendations. This review integrates data from different studies on the use of inotropes and vasopressors in patients with cardiogenic shock, proposing a therapeutic scheme for the pharmacological treatment of patients in cardiogenic shock according to the patient's hemodynamic profile.
Serviço de Cardiologia, Centro Hospitalar do Algarve, Faro, Portugal. Electronic address: pina_amado@hotmail.com.
José
J
Amado
Serviço de Cardiologia, Centro Hospitalar do Algarve, Faro, Portugal.
Paula
P
Gago
Serviço de Cardiologia, Centro Hospitalar do Algarve, Faro, Portugal.
Walter
W
Santos
Serviço de Cardiologia, Centro Hospitalar do Algarve, Faro, Portugal.
Jorge
J
Mimoso
Serviço de Cardiologia, Centro Hospitalar do Algarve, Faro, Portugal.
Ilídio
I
de Jesus
D002316:Cardiotonic Agents / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D006439:Hemodynamics; D006801:Humans; D009200:Myocardial Contraction / Q000187:drug effects / Q000502:physiology; D012770:Shock, Cardiogenic / Q000188:drug therapy* / Q000401:mortality; D014662:Vasoconstrictor Agents / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*
D002316:Cardiotonic Agents; D014662:Vasoconstrictor Agents
Cardiogenic shock; Choque cardiogénico; Inotropes; Inotrópicos; Vasopressores; Vasopressors