New minor spirostanol glycosides from Helleborus thibetanus.
Phytochemical reinvestigation of the dried roots and rhizomes of Helleborus thibetanus afforded four new minor spirostanol glycosides (1-4) and four known spirostanol glycosides (5-8). Their structures were determined on the basis of spectroscopic analyses, including 1D and 2D NMR experiments, together with HR-ESI-MS and IR measurements and the results of acid hydrolysis.
a Tianjin Key Laboratory for Modern Drug Delivery and High-Efficiency, School of Pharmaceutical Science and Technology , Tianjin University , Tianjin , P.R. China.
Hui
H
Zhang
a Tianjin Key Laboratory for Modern Drug Delivery and High-Efficiency, School of Pharmaceutical Science and Technology , Tianjin University , Tianjin , P.R. China.|b School of Pharmaceutical Science and Technology , Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) , Tianjin , P.R. China.
Yan-Fang
YF
Su
a Tianjin Key Laboratory for Modern Drug Delivery and High-Efficiency, School of Pharmaceutical Science and Technology , Tianjin University , Tianjin , P.R. China.|c Pharmaceutical Engineering Department, School of Biological Science and Technology , University of Jinan , Shandong , P.R. China.
Feng-Ying
FY
Yang
d Tianjin Key Laboratory of TCM Chemistry and Analysis , Tianjin University of Traditional Chinese Medicine , Tianjin , P.R. China.
Xiu-Mei
XM
Gao
D006027:Glycosides / Q000737:chemistry*; D039322:Helleborus / Q000737:chemistry*; D006868:Hydrolysis; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D027343:Rhizome / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization; D013150:Spirostans / Q000737:chemistry* / Q000302:isolation & purification
D006027:Glycosides; D013150:Spirostans; C000619394:thibetanoside A; C000619373:thibetanoside B; C000619395:thibetanoside C
Helleborus; Ranunculaceae; spirostanol; steroidal saponins