MyTH4-FERM myosins in the assembly and maintenance of actin-based protrusions.
Unconventional myosins are actin-based molecular motors that serve a multitude of roles within the cell. One group of myosin motors, the MyTH4-FERM myosins, play an integral part in building and maintaining finger-like protrusions, which allow cells to interact with their external environment. Suggested to act primarily as transporters, these motor proteins enrich adhesion molecules, actin-regulatory proteins and other factors at the tips of filopodia, microvilli, and stereocilia. Below we review data from biophysical, biochemical, and cell biological studies, which implicate these myosins as central players in the assembly, maintenance and function of actin-based protrusions.
Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, 3154 MRB III, PMB 407935, 465 21st Avenue South, Nashville, TN 37240-7935, United States.
Meredith L
ML
Weck
Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, 3154 MRB III, PMB 407935, 465 21st Avenue South, Nashville, TN 37240-7935, United States.
Nathan E
NE
Grega-Larson
Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, 3154 MRB III, PMB 407935, 465 21st Avenue South, Nashville, TN 37240-7935, United States. Electronic address: matthew.tyska@vanderbilt.edu.
Matthew J
MJ
Tyska
D000199:Actins / Q000378:metabolism; D000818:Animals; D022081:Cell Surface Extensions / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D009218:Myosins / Q000032:analysis / Q000378:metabolism*; D011554:Pseudopodia / Q000378:metabolism
D000199:Actins; D009218:Myosins