Turning Over Paradigms in Protein Decay.
Protein degradation is as important as synthesis in regulating protein expression, but protein degradation kinetics are relatively less understood. In a recent paper in Cell, McShane et al. (2016) use a novel methodology to demonstrate that many proteins decay non-exponentially, with biological implications for proteins in heteromeric complexes and in aneuploidy.
German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany; Excellence Cluster Cell Networks, Heidelberg University, 69120 Heidelberg, Germany.
Gertjan
G
Kramer
German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany; Excellence Cluster Cell Networks, Heidelberg University, 69120 Heidelberg, Germany. Electronic address: j.krijgsveld@dkfz-heidelberg.de.
Jeroen
J
Krijgsveld
D007700:Kinetics; D011499:Protein Processing, Post-Translational; D011506:Proteins; D059748:Proteolysis; D040901:Proteomics
D011506:Proteins