Cerebral amyloid angiopathy in a young man with a history of traumatic brain injury: a case report and review of the literature.
Cerebral amyloid angiopathy (CAA), a cause of recurrent and multiple lobar hemorrhages, characteristically occurs in persons aged ≥55 years. We report a case of a 32-year-old male who had recurrent hemorrhage in the left multiple lobes, with a history of traumatic brain injury and hematoma evacuation at the age of 1 year. He underwent surgical treatment and was histopathologically diagnosed as having CAA. The literature review yielded six CAA cases, including ours, aged less than 55 years. All were male and four had histories of severe TBI, suggesting that male sex and TBI may be associated with CAA in young persons.
Department of Neurosurgery, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo, Kyoto, 606-8507, Japan.
Yoichi
Y
Nakayama
Department of Neurosurgery, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo, Kyoto, 606-8507, Japan. mineharu@kuhp.kyoto-u.ac.jp.
Yohei
0000-0002-6346-3999
Y
Mineharu
Department of Neurosurgery, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo, Kyoto, 606-8507, Japan.
Yoshiki
Y
Arawaka
Department of Neurosurgery, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo, Kyoto, 606-8507, Japan.
Sei
S
Nishida
Department of Neurosurgery, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo, Kyoto, 606-8507, Japan.
Hirofumi
H
Tsuji
Clinical Genetics Unit, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo, Kyoto, 606-8507, Japan.
Hidehiko
H
Miyake
Department of Diagnostic Pathology, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo, Kyoto, 606-8507, Japan.
Maki
M
Yamaguchi
Department of Diagnostic Pathology, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo, Kyoto, 606-8507, Japan.
Sachiko
S
Minamiguchi
Department of Neurosurgery, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo, Kyoto, 606-8507, Japan.
Yasushi
Y
Takagi
Department of Neurosurgery, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo, Kyoto, 606-8507, Japan.
Susumu
S
Miyamoto
D000328:Adult; D000070642:Brain Injuries, Traumatic / Q000150:complications*; D016657:Cerebral Amyloid Angiopathy / Q000150:complications / Q000209:etiology*; D002543:Cerebral Hemorrhage / Q000209:etiology*; D006801:Humans; D008297:Male
Amyloid angiopathy; Cerebral; Lobar hemorrhage; Traumatic brain injury; Young