Glaucoma Diagnostic Capability of Global and Regional Measurements of Isolated Ganglion Cell Layer and Inner Plexiform Layer.
OBJECTIVE
To compare glaucoma diagnostic capability of global/regional macular layer parameters in different-sized grids.


METHODS
Serial horizontal spectral-domain optical coherence tomography scans of macula were obtained. Automated macular grids with diameters of 3, 3.45, and 6 mm were used. For each grid, 10 parameters (total volume; average thicknesses in 9 regions) were obtained for 5 layers: macular retinal nerve fiber layer (mRNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), ganglion cell-inner plexiform layer (GCIPL; GCL+IPL), and ganglion cell complex (GCC; mRNFL+GCL+IPL).


RESULTS
Sixty-nine normal eyes (69 subjects) and 87 glaucomatous eyes (87 patients) were included. For the total volume parameter, the area under the receiver operating characteristic curves (AUCs) in 6-mm grid were larger than the AUCs in 3- and 3.45-mm grids for GCL, GCC, GCIPL, and mRNFL (all P<0.020). For the average thickness parameters, the best AUC in 6-mm grid (T2 region for GCL, IPL, and GCIPL; I2 region for mRNFL and GCC) was greater than the best AUC in 3-mm grid for GCL, GCC, and mRNFL (P<0.045). The AUC of GCL volume (0.920) was similar to those of GCC (0.920) and GCIPL (0.909) volume. The AUC of GCL T2 region thickness (0.942) was similar to those of GCC I2 region (0.942) and GCIPL T2 region (0.934) thickness.


CONCLUSIONS
Isolated macular GCL appears to be as good as GCC and GCIPL in glaucoma diagnosis, while IPL does not. Larger macular grids may be better at detecting glaucoma. Each layer has a characteristic region with the best glaucoma diagnostic capability.
*Moise and Chella Safra Advanced Ocular Imaging Laboratory, Einhorn Clinical Research Center, New York Eye and Ear Infirmary of Mount Sinai ‡Department of Ophthalmology, Manhattan Eye, Ear and Throat Hospital ∥Bernard and Shirlee Brown Glaucoma Research Laboratory, Columbia University Medical Center, Harkness Eye Institute, New York §Department of Ophthalmology, Hofstra Northwell School of Medicine, Hempstead, NY †George Washington University School of Medicine and Health Sciences, Washington, DC.
Jason L
JL
Chien
Mark P
MP
Ghassibi
Thipnapa
T
Patthanathamrongkasem
Ramiz
R
Abumasmah
Michael S
MS
Rosman
Alon
A
Skaat
Celso
C
Tello
Jeffrey M
JM
Liebmann
Robert
R
Ritch
Sung Chul
SC
Park
D000368:Aged; D019540:Area Under Curve; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D005901:Glaucoma / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D007429:Intraocular Pressure; D008266:Macula Lutea / Q000000981:diagnostic imaging / Q000473:pathology*; D008875:Middle Aged; D011446:Prospective Studies; D012372:ROC Curve; D012165:Retinal Ganglion Cells / Q000473:pathology*; D055351:Retinal Neurons / Q000473:pathology*; D041623:Tomography, Optical Coherence / Q000379:methods