Phytochemicals in the treatment of ovarian cancer.
Ovarian cancer ranks 5thamong the most common gynecologic cancers and causes the highest mortality in females. Here, we discuss the role of a group of natural products that are being used in treatment and prevention of a host of cancers including ovarian cancer. Some plants and nutraceuticals and their polyphenolic constituents such as flavones, flavonoids, and antioxidants have shown cytotoxic effects on cancer cells bothin vitroandin vivo. While phytochemicals do not harm normal cells, they have been found to be cytotoxic to cancer cells by virtue of inhibition of proliferation and/or induction of apoptosis, making them ideal in cancer therapeutics or as adjunct to conventional treatment regimens.
Department of Zoology, University of Lucknow, Lucknow, India 226007, juhirais44@gmail.com.
Juhi
J
Rais
Department of Zoology, University of Lucknow, Lucknow, India 226007.
Asif
A
Jafri
Department of Zoology, University of Lucknow, Lucknow, India 226007.
Sahabjada
S
Siddiqui
Department of Zoology, University of Lucknow, Lucknow, India 226007.
Madhu
M
Tripathi
Department of Zoology, University of Lucknow, Lucknow, India 226007.
Mohammad
M
Arshad
D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008055:Lipids / Q000737:chemistry / Q000627:therapeutic use; D010051:Ovarian Neoplasms / Q000188:drug therapy*; D010636:Phenols / Q000737:chemistry / Q000627:therapeutic use; D064209:Phytochemicals / Q000145:classification / Q000627:therapeutic use*; D013457:Sulfur Compounds / Q000737:chemistry / Q000627:therapeutic use; D013729:Terpenes / Q000737:chemistry / Q000627:therapeutic use
D000972:Antineoplastic Agents, Phytogenic; D008055:Lipids; D010636:Phenols; D064209:Phytochemicals; D013457:Sulfur Compounds; D013729:Terpenes