Population Differentiations and Phylogenetic Analysis of Tibet and Qinghai Tibetan Groups Based on 30 InDel Loci.
In recent years, Insertion/Deletion (InDel) polymorphisms have become a hot area of forensic research. In this study, 30 InDel loci were selected to investigate the genetic polymorphisms of Tibetan groups, which are from Tibet Autonomous Region and Qinghai province of China, and explore the genetic relationships between Tibetan groups and other groups. Allele frequencies of the 30 InDel loci ranged from 0.1219 (HLD111) to 0.5609 (HLD57) in the Tibet Tibetan group and 0.1639 (HLD118) to 0.5655 (HLD124) in the Qinghai Tibetan group. The combined power of discrimination, matching probability, and power of exclusion were 0.999999999986, 0.999999988, and 0.9913 in the Tibet Tibetan group, respectively, and 0.99999999999204, 0.9999999796, and 0.9862 in the Qinghai Tibetan group. The results of principal component analysis, phylogenetic tree, and population structure demonstrated that the four Tibetan groups (Tibetan1, Tibetan2, Tibet, and Qinghai Tibetan groups) clustered together and had relatively close genetic relationships with nine Asian groups and then European and Amerindian groups.
1 Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University , Xi'an, China .|2 Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, College of Stomatology, Xi'an Jiaotong University , Xi'an, China .
Yuxin
Y
Guo
3 College of Life Sciences, Shaanxi Normal University , Xi'an, People's Republic of China, China .|4 Blood Center of Shaanxi Province , Xi'an, People's Republic of China, China .
Chunmei
C
Shen
1 Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University , Xi'an, China .|2 Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, College of Stomatology, Xi'an Jiaotong University , Xi'an, China .
Haotian
H
Meng
1 Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University , Xi'an, China .|2 Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, College of Stomatology, Xi'an Jiaotong University , Xi'an, China .
Qian
Q
Dong
1 Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University , Xi'an, China .|2 Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, College of Stomatology, Xi'an Jiaotong University , Xi'an, China .
Tingting
T
Kong
1 Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University , Xi'an, China .|5 People's Hospital of Arong Banner , Hulun Buir City, People's Republic of China, China .
Chunhua
C
Yang
6 Medical Genetic Institute of Henan Province, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University , Zhengzhou, People's Republic of China, China .
Hongdan
H
Wang
7 Department of Radiology, The Second Affiliated Hospital of Xi'an Jiaotong University , Xi'an, People's Republic of China, China .
Rui
R
Jin
1 Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University , Xi'an, China .|2 Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, College of Stomatology, Xi'an Jiaotong University , Xi'an, China .
Bofeng
B
Zhu
D000483:Alleles; D044466:Asian People / Q000235:genetics*; D002681:China; D005006:Ethnicity / Q000235:genetics*; D053803:Forensic Genetics; D005787:Gene Frequency; D056426:Genetic Loci; D015894:Genome, Human; D006801:Humans; D054643:INDEL Mutation; D010802:Phylogeny; D058974:Phylogeography; D011110:Polymorphism, Genetic
InDel; Tibetan groups; forensic research; genetic relationship