Triterpenoids from Ainsliaea yunnanensis Franch. and Their Biological Activities.
One new pentacyclic triterpenoid, 3β-carboxylicfilic-4(23)-ene (1), and three known pentacyclic triterpenoids, adian-5-en-3α-ol (2), fernenol (3), and fern-7-en-3β-ol (4) were isolated from the petroleum ether phase of the ethanolic extract ofAinsliaea yunnanensisFranch. Their structures were established by spectroscopic methods including 1-D and 2-D NMR, and MS experiments. Compounds1,2,3, and4showed significant selective cytotoxicity against human acute monocytic leukemia cell line (THP-1) with IC50values of 5.12 μM, 1.78 μM, 1.74 μM, and 1.75 μΜ, respectively. Compound1also showed an anti-inflammatory effect through the inhibition of the activity of NF-κB by blocking the nuclear translocation of p65.
Key Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education, College of Life Science, Beijing Normal University, Beijing 100875, China. lijinjie.7785004@163.com.|Beijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University, Beijing 100191, China. lijinjie.7785004@163.com.
Jinjie
J
Li
Beijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University, Beijing 100191, China. 18801127628@163.com.
Bo
B
Zhang
Key Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education, College of Life Science, Beijing Normal University, Beijing 100875, China. liuhailing@bnu.edu.cn.
Hailing
H
Liu
Key Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education, College of Life Science, Beijing Normal University, Beijing 100875, China. zhangxuan1328@163.com.
Xuan
X
Zhang
Beijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University, Beijing 100191, China. shangxiaoya@buu.edu.cn.
Xiaoya
X
Shang
Key Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education, College of Life Science, Beijing Normal University, Beijing 100875, China. cqzhao163@163.com.
Changqi
C
Zhao
D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology; D019659:Asteraceae / Q000737:chemistry*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D016328:NF-kappa B / Q000378:metabolism*; D010766:Phosphorylation / Q000187:drug effects; D021241:Spectrometry, Mass, Electrospray Ionization; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*
D000893:Anti-Inflammatory Agents; D004365:Drugs, Chinese Herbal; D016328:NF-kappa B; D014315:Triterpenes
Ainsliaea yunnanensis; NMR; activity; structures; triterpenoids