l-Proline, GABA Synthesis and Gamma Oscillations in Schizophrenia.
Altered inhibition from parvalbumin-containing GABA neurons is thought to contribute to impaired gamma frequency oscillations and cognitive deficits in schizophrenia. Crabtree and colleagues report that proline dehydrogenase deficits produce excessive cytosolic levels of the GABA-mimetic l-proline which impairs GABA synthesis and gamma oscillations in a manner that mimics schizophrenia.
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA. Electronic address: volkdw@upmc.edu.
David W
DW
Volk
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Guillermo
G
Gonzalez-Burgos
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA; Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15213, USA.
David A
DA
Lewis
D059330:GABAergic Neurons; D010320:Parvalbumins; D017397:Prefrontal Cortex; D011392:Proline; D012559:Schizophrenia; D005680:gamma-Aminobutyric Acid
D010320:Parvalbumins; D005680:gamma-Aminobutyric Acid; D011392:Proline
22q11; GAD; cognition; parvalbumin; postmortem; prefrontal cortex; proline dehydrogenase