Frequency of Thyroid Peroxidase Antibody and its Association with Miscarriages Among Pregnant Women.
OBJECTIVE
To measure the frequency of thyroid peroxidase antibody (TPO Ab) among clinically euthyroid pregnant women during first trimester and determine its association with pregnancy outcome as miscarriage or live birth by estimating the relative risk.


METHODS
Cohort study.


METHODS
Section of Chemical Pathology, Department of Pathology and Laboratory Medicine and the Gynaecology and Obstetric outpatient clinics of the Aga Khan University Hospital, Karachi, from July to December 2012.


METHODS
The study subjects comprised of apparently euthyroid pregnant women, who were tested for TPO Ab during first trimester of pregnancy and followed till pregnancy outcomes. Pregnancy outcome was noted and relative risk was determined.


RESULTS
TPO Ab was found positive in 127 (13.5%) pregnant women from a cohort of 943 subjects. A2.03% increased risk of miscarriages was observed in TPO Ab positive subjects.


CONCLUSIONS
There was a positive association of presence of TPO Ab with loss of pregnancy.
Department of Pathology, Dow International Medical College, Dow University of Health Sciences, Karachi.
Sahar
S
Iqbal
Department of Pathology and Laboratory Medicine, The Aga Khan University Hospital, Karachi.
Farooq
F
Ghani
Department of Obstetrics and Gynaecology, The Aga Khan University Hospital, Karachi.
Rahat
R
Qureshi
D000022:Abortion, Spontaneous; D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D001327:Autoimmune Diseases / Q000453:epidemiology; D015331:Cohort Studies; D005260:Female; D006044:Goiter, Nodular / Q000453:epidemiology / Q000276:immunology; D006801:Humans; D007453:Iodide Peroxidase / Q000276:immunology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology / Q000276:immunology; D011256:Pregnancy Outcome; D011261:Pregnancy Trimester, First
D001323:Autoantibodies; C056626:thyroid microsomal antibodies; D007453:Iodide Peroxidase