Interleukin-22 Might Act as a Double-Edged Sword in Type 2 Diabetes and Coronary Artery Disease.
Type 2 diabetes mellitus (T2DM) and coronary artery disease (CAD) are both characterized by chronic low-grade inflammation. The role of Th17 and its related cytokines in T2DM and CAD is unclear. Here we investigated the serum levels of five Th17-related cytokines (IL-17, IL-22, MIP-3α, IL-9, and IL-27) in T2DM, CAD, and T2DM-CAD comorbidity patients. IL-22 was found to be elevated in all three conditions. Elevated serum IL-22 was independently associated with the incidence of T2DM and CAD. Conversely, IL-22 was found to protect endothelial cells from glucose- and lysophosphatidylcholine- (LPC-) induced injury, and IL-22R1 expression on endothelial cells was increased upon treatment with high glucose and LPC. Blocking of IL-22R1 with IL-22R1 antibody diminished the protective role of IL-22. Our results suggest that IL-22 functions as a double-edged sword in T2DM and CAD and that IL-22 may be used in the treatment of chronic inflammatory diseases such as T2DM and CAD.
Department of Geriatrics, The Second Affiliated Hospital, Nanjing Medical University, Jiangsu 210029, China.
Fangchen
0000-0001-9502-8126
F
Gong
Department of Neurology, The Second Affiliated Hospital, Nanjing Medical University, Jiangsu 210029, China.
Jin
J
Wu
Department of Geriatrics, The Second Affiliated Hospital, Nanjing Medical University, Jiangsu 210029, China.
Ping
P
Zhou
Department of Geriatrics, The Second Affiliated Hospital, Nanjing Medical University, Jiangsu 210029, China.
Mengyao
M
Zhang
Department of Geriatrics, The Second Affiliated Hospital, Nanjing Medical University, Jiangsu 210029, China.
Jingning
J
Liu
Department of Geriatrics, The Second Affiliated Hospital, Nanjing Medical University, Jiangsu 210029, China.
Ying
Y
Liu
Department of Geriatrics, The Second Affiliated Hospital, Nanjing Medical University, Jiangsu 210029, China.
Xiang
0000-0001-8351-1778
X
Lu
Department of Geriatrics, The Second Affiliated Hospital, Nanjing Medical University, Jiangsu 210029, China.
Zhengxia
0000-0002-2132-6064
Z
Liu
D000328:Adult; D000368:Aged; D017209:Apoptosis; D001786:Blood Glucose / Q000032:analysis; D002470:Cell Survival; D003324:Coronary Artery Disease / Q000097:blood*; D016207:Cytokines / Q000097:blood / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005260:Female; D005947:Glucose / Q000378:metabolism; D061307:Human Umbilical Vein Endothelial Cells; D006801:Humans; D007249:Inflammation; D007378:Interleukins / Q000097:blood / Q000502:physiology*; D008244:Lysophosphatidylcholines / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D058504:Th17 Cells / Q000166:cytology; D000097043:Interleukin-22
D001786:Blood Glucose; D016207:Cytokines; D005947:Glucose; D007378:Interleukins; D008244:Lysophosphatidylcholines; D000097043:Interleukin-22