Risk of uterine, ovarian and breast cancer following pelvic inflammatory disease: a nationwide population-based retrospective cohort study.
Pelvic inflammatory disease (PID) is characterized by infection and inflammation of the upper genital tract in women and is associated with health sequelae. We used a nationwide population-based retrospective cohort study to explore the relationship between PID and the subsequent development of gynecological cancers including ovarian, breast or uterine cancer.



We identified subjects diagnosed with PID between January 1st, 2000 and December 31st, 2002 in the Taiwan National Health Insurance Research Database. A comparison cohort constructed for patients without PID were matched according to age and sex. All PID patients and control groups were observed until diagnosed with ovarian, breast or uterine cancer, or until death, withdrawal from the NHI system, or until December 31st, 2009.



The PID cohort consisted of 32,268 patients, and an equal number of matched controls without PID. The adjusted hazard ratio (HR) of ovarian, breast or uterine cancer in subjects with PID were: HR 1.326 (95 % confidence interval: 0.775-2.269), HR: 1.039 (95 % confidence interval: 0.862-1.252), and HR: 1.439 (95 % confidence interval: 0.853-2.426) respectively in comparison with controls during follow-up.



This large nationwide population-based cohort study suggests that there is no increased risk for ovarian, breast or uterine cancer among women who have PID compared to a matching population.
School of Medicine, National Yang-Ming University, Taipei, Taiwan.|Department of Psychiatry, Chiayi Branch, Taichung Veterans General Hospital, Chiayi, Taiwan.|Department of Information Management, National Chung-Cheng University, Chiayi, Taiwan.
Cheng-Che
CC
Shen
School of Medicine, National Yang-Ming University, Taipei, Taiwan.|Department of Psychiatry, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
Li-Yu
LY
Hu
School of Medicine, National Yang-Ming University, Taipei, Taiwan.|Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan.
Albert C
AC
Yang
Department of Dental Technology and Materials, Central Taiwan University of Science and Technology, Taichung, Taiwan.
Yung-Yen
YY
Chiang
Department of Obstetrics and Gynecology, Taipei Tzu Chi Hospital, Taipei, Taiwan.|School of Medicine, Tzu Chi University, Hualien, Taiwan.
Jeng-Hsiu
JH
Hung
School of Medicine, National Yang-Ming University, Taipei, Taiwan. tsai610913@gmail.com.|Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan. tsai610913@gmail.com.
Shih-Jen
0000-0002-9987-022X
SJ
Tsai
D000328:Adult; D001943:Breast Neoplasms / Q000453:epidemiology / Q000209:etiology*; D016022:Case-Control Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000453:epidemiology / Q000209:etiology*; D000292:Pelvic Inflammatory Disease / Q000150:complications*; D011379:Prognosis; D012189:Retrospective Studies; D013624:Taiwan / Q000453:epidemiology; D014594:Uterine Neoplasms / Q000453:epidemiology / Q000209:etiology*; D055815:Young Adult
Breast cancer; Ovarian cancer; Pelvic inflammatory disease; Retrospective cohort study; Uterine cancer