Inorganic oxides with potential application in the preparation of a68Ge/68Ga generator system.
The ion exchange properties of some tin and titanium oxides with potential application in the development of a68Ge/68Ga generator were determined. The best potential candidates, SnO2and calcined SnO2, were further characterized by powder X-Ray Diffraction (XRD), Scanning Electron Microscopy (SEM) and Brunauer-Emmett-Teller (BET) surface area analysis and its radiation stability was also determined. Two68Ge/68Ga pilot generators (1.85MBq) based on SnO2and calcined SnO2were developed and evaluated over 100 and 200 elution cycles respectively, using as eluent different concentrations of HCl. The generator based on calcined SnO2showed higher68Ga elution yield and lower68Ge content in the eluate (75-80% and <3×10-3% respectively, 1-2M HCl) than the generator based on unheated SnO2(60-65% and <1×10-1% respectively, 1-2M HCl). Nano-crystalline calcined SnO2proved to be a promising sorbent; therefore it should be considered as an attractive candidate to develop68Ge/68Ga generators to produce gallium-68 for biomedical purposes.
Biomedical Applications and Pharmacokinetics Unit, CIEMAT, Avda. Complutense 40, 28040 Madrid, Spain.
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Romero
Biomedical Applications and Pharmacokinetics Unit, CIEMAT, Avda. Complutense 40, 28040 Madrid, Spain. Electronic address: mangel.morcillo@ciemat.es.
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Morcillo
(68)Ge/(68)Ga generator; Gallium-68; Nano-SnO(2)