Sprue-like enteropathy associated with olmesartan in a patient with villous atrophy, HLA-DQ2 genotype and antinuclear antibodies.
We describe a new case of enteropathy with villous atrophy in a patient suffering from arterial hypertension treated with olmesartan. The molecular and serological studies showed anti-nuclear antibodies (ANA) and haplotype HLA-DQ2 positive, as well as negative results for anti-transglutaminase, anti-endomysium and anti-enterocytes antibodies. A duodenal villous atrophy was suspected by upper gastrointestinal endoscopy, which was confirmed by histopathology. The morphological picture was suggestive of sprue-like enteropathy with severe lymphoid infiltration and predominant T lymphoid cells.
Servicio de Anatomía Patológica, Instituto Valenciano de Oncología, España.
Isidro
I
Machado
Gastroenterología, IVO, España.
María
M
Reolid
Unidad de Aparato Digestivo, Instituto Valenciano de Oncología, España.
Fernando
F
Martínez de Juan
Digestivo , Instituto valenciano de oncología , España .
Carmen
C
Martínez Lapiedra
Aparato Digestivo, Instituto Valenciano de Oncolgía, España.
Fernanda
F
Maia de Alcántara
D000368:Aged; D000974:Antibodies, Antinuclear / Q000276:immunology*; D000924:Anticholesteremic Agents / Q000009:adverse effects*; D001284:Atrophy; D002446:Celiac Disease / Q000000981:diagnostic imaging*; D005767:Gastrointestinal Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging* / Q000235:genetics; D005838:Genotype; D006683:HLA-DQ Antigens / Q000235:genetics*; D006801:Humans; D007093:Imidazoles / Q000009:adverse effects*; D008297:Male; D013777:Tetrazoles / Q000009:adverse effects*
D000974:Antibodies, Antinuclear; D000924:Anticholesteremic Agents; D006683:HLA-DQ Antigens; C053186:HLA-DQ2 antigen; D007093:Imidazoles; D013777:Tetrazoles; C437965:olmesartan