Combining a Ru(ii)-arene complex with a NO-releasing nitrate-ester ligand generates cytotoxic activity.
A Ru(ii) arene complex with a NO-releasing 4-nitrooxymethyl-pyridine ligand shows increased cytotoxicity against the non-small cell lung cancer cell line A549 as compared to either the free ligand or the unfunctionalized complex. EPR spin-trapping studies show that NO release is selective, being limited in phosphate buffered saline or human serum, but promoted by glutathione.
Department of Chemistry, Simon Fraser University, Burnaby, BC, CanadaV5A 1S6. cwalsby@sfu.ca.
Jian
J
Zhao
Department of Chemistry, Simon Fraser University, Burnaby, BC, CanadaV5A 1S6. cwalsby@sfu.ca.
Kathleen E
KE
Prosser
Department of Chemistry, Simon Fraser University, Burnaby, BC, CanadaV5A 1S6. cwalsby@sfu.ca.
Stephanie W
SW
Chang
Department of Chemistry, Simon Fraser University, Burnaby, BC, CanadaV5A 1S6. cwalsby@sfu.ca.
Shradha P
SP
Zakharia
Department of Chemistry, Simon Fraser University, Burnaby, BC, CanadaV5A 1S6. cwalsby@sfu.ca.
Charles J
CJ
Walsby