The emerging role of long non-coding RNAs in endometrial cancer.
The human genome is pervasively transcribed and approximately 98% of the genome is non-coding. Long non-coding RNAs (lncRNAs) are a heterogeneous group of RNA transcripts that are >200 nucleotides in length with minimal to no protein-coding potential. Similar to proteins, lncRNAs have important biological functions in both normal cells and disease states including many types of cancer. This review summarizes recent advances in our understanding of lncRNAs in cancer biology and highlights the potential for lncRNA as diagnostic biomarkers and therapeutics. Herein we focus on the poorly understood role of lncRNAs in endometrial cancer, the most common gynecologic malignancy in the developed world.
School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia.
Konii
K
Takenaka
School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia.
Bei Jun
BJ
Chen
Division of Gynecologic Oncology, Obstetrics and Gynecology Department, University of Virginia Health System, Charlottesville, VA 22908, USA.
Susan C
SC
Modesitt
School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia.
Frances L
FL
Byrne
School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia.
Kyle L
KL
Hoehn
School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia. Electronic address: m.janitz@unsw.edu.au.
Michael
M
Janitz
D016889:Endometrial Neoplasms / Q000235:genetics*; D005260:Female; D006801:Humans; D062085:RNA, Long Noncoding / Q000235:genetics*
D062085:RNA, Long Noncoding
Endometrial cancer; gene expression; lincRNAs; long non-coding RNAs; transcriptome