Different dimensions of the prediction error as a decisive factor for the triggering of the reconsolidation process.
The reconsolidation process is the mechanism by which strength and/or content of consolidated memories are updated. Prediction error (PE) is the difference between the prediction made and current events. It is proposed as a necessary condition to trigger the reconsolidation process. Here we analyzed deeply the role of the PE in the associative memory reconsolidation in the crab Neohelice granulata. An incongruence between the learned temporal relationship between conditioned and unconditioned stimuli (CS-US) was enough to trigger the reconsolidation process. Moreover, after a partial reinforced training, a PE of 50% opened the possibility to labilize the consolidated memory with a reminder which included or not the US. Further, during an extinction training a small PE in the first interval between CSs was enough to trigger reconsolidation. Overall, we highlighted the relation between training history and different reactivation possibilities to recruit the process responsible of memory updating.
Laboratorio de Neurobiología de la Memoria, Departamento de Fisiología y Biología Molecular y Celular, IFIBYNE-CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pab. II, 2(do) piso, Buenos Aires, Argentina.
M
M
Agustina López
Laboratorio de Neurobiología de la Memoria, Departamento de Fisiología y Biología Molecular y Celular, IFIBYNE-CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pab. II, 2(do) piso, Buenos Aires, Argentina.
M
M
Jimena Santos
Laboratorio de Neurobiología de la Memoria, Departamento de Fisiología y Biología Molecular y Celular, IFIBYNE-CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pab. II, 2(do) piso, Buenos Aires, Argentina.
Santiago
S
Cortasa
Laboratorio de Neurobiología de la Memoria, Departamento de Fisiología y Biología Molecular y Celular, IFIBYNE-CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pab. II, 2(do) piso, Buenos Aires, Argentina.
Rodrigo S
RS
Fernández
Laboratorio de Redes Neuronales, Departamento de Fisiología y Biología Molecular y Celular, IFIBYNE-CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pab. II, 2(do) piso, Buenos Aires, Argentina.
Martin
M
Carbó Tano
Laboratorio de Neurobiología de la Memoria, Departamento de Fisiología y Biología Molecular y Celular, IFIBYNE-CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pab. II, 2(do) piso, Buenos Aires, Argentina. Electronic address: mpedreira@fbmc.fcen.uba.ar.
María E
ME
Pedreira
D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D003386:Brachyura; D003214:Conditioning, Classical / Q000502:physiology*; D005108:Extinction, Psychological / Q000502:physiology*; D008297:Male; D000069077:Memory Consolidation / Q000502:physiology*
Boundary conditions; Invertebrate; Memory reconsolidation; Prediction error; Temporal prediction error