Clinical characteristics of asymptomatic left ventricular diastolic dysfunction and its association with self-rated health and N-terminal B-type natriuretic peptide: a cross-sectional study.
OBJECTIVE
Left ventricular hypertrophy, obesity, hypertension, and N-terminal B-type natriuretic peptide (Nt-proBNP) predict left ventricular diastolic dysfunction with preserved systolic function (DD-PSF). Self-rated health (SRH) is shown to be associated with chronic diseases, but the association of SRH with DD-PSF is unclear. In light of the clinical implications of DD-PSF, the following goals are of considerable importance: (1) to determine the role of SRH in patients with DD-PSF in the general population and (2) to study the association between Nt-proBNP and DD-PSF.


RESULTS
The current study is a cross-sectional study conducted on a random sampling of a rural population. Individuals 30-75 years of age were consecutively subjected to conventional echocardiography and tissue velocity imaging. Data were collected on 500 (48%) men and 538 (52%) women (n= 1038). DD-PSF was the main outcome, and SRH and Nt-proBNP were the primary indicators. Diabetes mellitus, hypertension, and obesity were accounted for as major confounders of the association with SRH. DD-PSF was identified in 137 individuals, namely, 79 men (15.8%) and 58 women (10.8%). In a multivariate regression model, SRH (OR 2.95; 95% CI 1.02-8.57) and Nt-proBNP (quartile 4 vs. quartile 1 OR 4.23; 95% CI 1.74-10.26) were both independently associated with DD-PSF.


CONCLUSIONS
SRH, evaluated based on a descriptive question on general health, should be included in the diagnostic process of DD-PSF. In agreement with previous studies, our study confirms that Nt-proBNP is a major indicator of DD-PSF.
Department of Public Health and Community Medicine/Primary Health Care The Sahlgrenska Academy at the University of Gothenburg Göteborg Sweden.
Nasser S
0000-0002-2340-3676
NS
Ahmadi
Department of Clinical Sciences in Malmö, Family Medicine Lund University Malmö Sweden.
Louise
L
Bennet
Department of Public Health and Community Medicine/Primary Health CareThe Sahlgrenska Academy at the University of GothenburgGöteborgSweden; Department of Clinical Sciences in Malmö, Social Medicine and Global HealthLund UniversityMalmöSweden.
Charlotte A
CA
Larsson
School of Health and Education University of Skövde Skövde Sweden.
Susanne
S
Andersson
Department of Public Health and Community Medicine/Primary Health Care The Sahlgrenska Academy at the University of Gothenburg Göteborg Sweden.
Jörgen
J
Månsson
Department of Public Health and Community Medicine/Primary Health Care The Sahlgrenska Academy at the University of Gothenburg Göteborg Sweden.
Ulf
U
Lindblad
Cross‐sectional; DD‐PSF; Diabetes mellitus; Nt‐proBNP; Population‐based; SRH