Amlodipine-induced gingival overgrowth in a child after liver transplant.
Drug-induced gingival overgrowth (GO) has been associated with phenytoin, cyclosporine, and calcium channel blocker therapies. This study reports the case of an 11-year-old girl who was referred for evaluation of GO, which had occurred over the last 6 months. Her medical history included a liver transplant due to biliary atresia 3 years ago, immunosuppressive therapy, and hypertension, which is why she was started on a daily intake of amlodipine. The intraoral examination showed generalized GO, and the treatment consisted of a gingivectomy. Subsequently, amlodipine was replaced with captopril and oral hygiene instructions. There was no recurrence of GO after 28 months of follow-up. Although GO may be related to the chronic use of amlodipine, such an association is uncommon in pediatrics, and the treatment consists of the replacement of medication combined with a surgical approach and plaque control.
Stomatology Department - A.C. Camargo Cancer Center, São Paulo/SP - Brazil .
André
A
Guollo
Stomatology Department - A.C. Camargo Cancer Center, São Paulo/SP - Brazil .
Ana Paula Molina
AP
Vivas
Stomatology Department - A.C. Camargo Cancer Center, São Paulo/SP - Brazil .
Rodrigo Nascimento
RN
Lopes
Department of Liver Transplantation - A.C. Camargo Cancer Center, São Paulo/SP - Brazil .
Gilda
G
Porta
Stomatology Department - A.C. Camargo Cancer Center, São Paulo/SP - Brazil.; Stomatology Department - Universidade de São Paulo, São Paulo/SP - Brazil.
Fábio Abreu
FA
Alves
Amlodipine; Gingival Overgrowth; Liver Transplantation