Ultradeformable Liposomes: a Novel Vesicular Carrier For Enhanced Transdermal Delivery of Procyanidins: Effect of Surfactants on the Formation, Stability, and Transdermal Delivery.
The aims of this work were to develop a novel vesicular carrier, procyanidins, ultradeformable liposomes (PUDLs), to expand the applications for procyanidins, and increase their stability and transdermal delivery. In this study, we prepared procyanidins ultradeformable liposomes using thin film hydration method and evaluated their encapsulation efficiency, vesicle deformability, storage stability, and skin permeation in vitro. The influence of different surfactants on the properties of PUDLs was also investigated. The results obtained showed that the PUDLs containing Tween 80 had a high entrapment efficiency (80.27 ± 0.99%), a small particle size (140.6 ± 19 nm), high elasticity, and prolonged drug release. Compared with procyanidins solution, the stability of procyanidins in PUDLs improved significantly when stored at 4, 25, and 30°C. The penetration rate of PUDLs was 6.25-fold greater than that of procyanidins solution. Finally, the results of our study suggested that PUDLs could increase the transdermal flux, prolong the release and improve the stability of procyanidins, and could serve as an effective dermal delivery system for procyanidins.
College of Pharmacy Engineering, Shenyang Pharmaceutical University, Wenhua Road, No.103, Shenyang, 110016, People's Republic of China.
Rencai
R
Chen
College of Pharmacy Engineering, Shenyang Pharmaceutical University, Wenhua Road, No.103, Shenyang, 110016, People's Republic of China.
Rongli
R
Li
College of Pharmacy Engineering, Shenyang Pharmaceutical University, Wenhua Road, No.103, Shenyang, 110016, People's Republic of China.
Qian
Q
Liu
College of Pharmacy Engineering, Shenyang Pharmaceutical University, Wenhua Road, No.103, Shenyang, 110016, People's Republic of China.
Chao
C
Bai
College of Pharmacy Engineering, Shenyang Pharmaceutical University, Wenhua Road, No.103, Shenyang, 110016, People's Republic of China.
Benlin
B
Qin
College of Pharmacy Engineering, Shenyang Pharmaceutical University, Wenhua Road, No.103, Shenyang, 110016, People's Republic of China.
Yue
Y
Ma
College of Pharmacy Engineering, Shenyang Pharmaceutical University, Wenhua Road, No.103, Shenyang, 110016, People's Republic of China. huagonglou314@163.com.
Jing
J
Han
D000279:Administration, Cutaneous; D000818:Animals; D044946:Biflavonoids / Q000008:administration & dosage* / Q000737:chemistry* / Q000378:metabolism; D002392:Catechin / Q000008:administration & dosage* / Q000737:chemistry* / Q000378:metabolism; D016503:Drug Delivery Systems / Q000379:methods*; D004355:Drug Stability; D008081:Liposomes / Q000378:metabolism; D008297:Male; D010316:Particle Size; D044945:Proanthocyanidins / Q000008:administration & dosage* / Q000737:chemistry* / Q000378:metabolism; D051381:Rats; D012869:Skin Absorption / Q000187:drug effects* / Q000502:physiology; D013501:Surface-Active Agents / Q000008:administration & dosage* / Q000737:chemistry* / Q000378:metabolism
D044946:Biflavonoids; D008081:Liposomes; D044945:Proanthocyanidins; D013501:Surface-Active Agents; C017674:procyanidin; D002392:Catechin
procyanidins; stability; surfactants; transdermal delivery; ultradeformable liposomes