An Immunomodulatory Device Improves Insulin Resistance in Obese Porcine Model of Metabolic Syndrome.
Obesity is associated with tissue inflammation which is a crucial etiology of insulin resistance. This inflammation centers around circulating monocytes which form proinflammatory adipose tissue macrophages (ATM). Specific approaches targeting monocytes/ATM may improve insulin resistance without the adverse side effects of generalized immunosuppression. In this regard, a biomimetic membrane leukocyte processing device, called the selective cytopheretic device (SCD), was evaluated in an Ossabaw miniature swine model of insulin resistance with metabolic syndrome. Treatment with the SCD in this porcine model demonstrated a decline in circulating neutrophil activation parameters and monocyte counts. These changes were associated with improvements in insulin resistance as determined with intravenous glucose tolerance testing. These improvements were also reflected in lowering of homeostatic model assessment- (HOMA-) insulin resistant (IR) scores for up to 2 weeks after SCD therapy. These results allow for the planning of first-in-man studies in obese type 2 diabetic patients.
Innovative BioTherapies, Inc., 650 Avis Drive, Suite 300, Ann Arbor, MI 48108, USA.
Angela J
AJ
Westover
Innovative BioTherapies, Inc., 650 Avis Drive, Suite 300, Ann Arbor, MI 48108, USA.
Kimberly A
0000-0003-1899-7876
KA
Johnston
Innovative BioTherapies, Inc., 650 Avis Drive, Suite 300, Ann Arbor, MI 48108, USA.
Deborah A
0000-0002-1541-2003
DA
Buffington
Innovative BioTherapies, Inc., 650 Avis Drive, Suite 300, Ann Arbor, MI 48108, USA; Department of Internal Medicine, University of Michigan Medical School, 4520C MSRB I, SPC 5651, 1150 W. Medical Center Dr., Ann Arbor, MI 48109, USA.
H David
0000-0002-4309-1614
HD
Humes
D000818:Animals; D019343:Citric Acid; D004195:Disease Models, Animal; D005112:Extracorporeal Circulation / Q000379:methods; D056747:Immunomodulation; D007249:Inflammation; D007333:Insulin Resistance; D007937:Leukapheresis / Q000379:methods*; D007962:Leukocytes; D008264:Macrophages / Q000276:immunology*; D024821:Metabolic Syndrome / Q000276:immunology* / Q000378:metabolism; D009000:Monocytes / Q000276:immunology*; D009504:Neutrophils / Q000276:immunology; D009765:Obesity / Q000276:immunology* / Q000378:metabolism; D013552:Swine; D013556:Swine, Miniature
D019343:Citric Acid