Thermoregulation as a disease tolerance defense strategy.
Physiological responses that occur during infection are most often thought of in terms of effectors of microbial destruction through the execution of resistance mechanisms, due to a direct action of the microbe, or are maladaptive consequences of host-pathogen interplay. However, an examination of the cellular and organ-level consequences of one such response, thermoregulation that leads to fever or hypothermia, reveals that these actions cannot be readily explained within the traditional paradigms of microbial killing or maladaptive consequences of host-pathogen interactions. In this review, the concept of disease tolerance is applied to thermoregulation during infection, inflammation and trauma, and we discuss the physiological consequences of thermoregulation during disease including tissue susceptibility to damage, inflammation, behavior and toxin neutralization.
The Salk Institute for Biological Studies, Immunobiology and Microbial Pathogenesis, 10010 North Torrey Pines Road, San DIego CA, USA.
Alexandria M Palaferri
AM
Schieber
The Salk Institute for Biological Studies, Immunobiology and Microbial Pathogenesis, 10010 North Torrey Pines Road, San DIego CA, USA jayres@salk.edu.
Janelle S
JS
Ayres
D000222:Adaptation, Physiological; D000818:Animals; D001519:Behavior; D001833:Body Temperature Regulation; D060467:Disease Resistance; D004198:Disease Susceptibility; D004734:Energy Metabolism; D005786:Gene Expression Regulation; D054884:Host-Pathogen Interactions; D006801:Humans; D056747:Immunomodulation; D007249:Inflammation / Q000209:etiology / Q000378:metabolism; D009928:Organ Specificity
fever; hypothermia; tolerance