STAT4gene polymorphism in patients after renal allograft transplantation.
BACKGROUND
STAT4 (signal transducer and activator of transcription 4) is involved in the regulation of innate and adaptive immune responses. Some studies have suggested that STAT4 may be involved in the immune response after graft transplantation. Several polymorphisms in the STAT4 gene have been identified. The most commonly studied polymorphism in the STAT4 gene is rs7574865. In our study, we examined whether this polymorphism is associated with the early and late functions of renal allografts.


METHODS
A total of 270 recipients of first renal transplants were included in the study. Single nucleotide polymorphisms (SNPs) within the STAT4 gene were genotyped using TaqMan genotyping assays.


RESULTS
There were no statistically significant associations between the STAT4 gene rs7574865 polymorphism and delayed graft function, acute rejection, chronic allograft dysfunction, post-transplant diabetes mellitus, or creatinine serum concentrations after transplantation.


CONCLUSIONS
Our results suggest a lack of association between the STAT4 rs7574865 SNP and kidney allograft function in the Polish population.
Department of Pharmacology, Pomeranian Medical University, Szczecin, Poland.
Ewa
E
Dąbrowska-Żamojcin
Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Szczecin, Poland.
Violetta
V
Dziedziejko
Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Szczecin, Poland.
Krzysztof
K
Safranow
Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, Szczecin, Poland.
Leszek
L
Domański
Department of Physiology, Pomeranian Medical University, Szczecin, Poland.
Sylwia
S
Słuczanowska-Głabowska
Department of Physiology, Pomeranian Medical University, Szczecin, Poland.
Andrzej
A
Pawlik
STAT4; graft; kidney; polymorphism