Serum sPECAM-1 and sVCAM-1 levels are associated with conversion to multiple sclerosis in patients with optic neuritis.
Platelet-Endothelial-Cell-Adhesion-Molecule-1 (PECAM-1) and Human-Vascular-CAM-1 (VCAM-1) are adhesion molecules involved in leukocyte-endothelial interaction. In our study serum levels of sPECAM-1 and sVCAM-1 were measured (ELISA) in twenty-nine patients during their first monosymptomatic optic neuritis (ON) episode. Anti-aquaporin-4-antibodies (AQP4-IgG) were detected with the cell-based assay. Patients were followed for seven years, during which 16/24 AQP4-IgG (-) patients developed MS and 2/5 AQP4-IgG (+) patients developed NMO. Patients who developed MS had significantly lower sPECAM-1 and sVCAM-1 than those who did not. Serum sPECAM-1 and sVCAM-1 may turn out to be useful biomarkers correlated with the risk of progression to MS after first ON incident.
Division of Neurochemistry and Neuropathology, Department of Neurology, Poznan University of Medical Sciences, 49, Przybyszewskiego st., 60-355 Poznan, Poland. Electronic address: akalinowskalyszczarz@ump.edu.pl.
Alicja
A
Kalinowska-Łyszczarz
Division of Neurochemistry and Neuropathology, Department of Neurology, Poznan University of Medical Sciences, 49, Przybyszewskiego st., 60-355 Poznan, Poland; Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland.
Sławomir
S
Michalak
Department of Neurology and Cerebrovascular Disorders, Poznan University of Medical Sciences, 34, Dojazd st., 60-631 Poznan, Poland.
Mikołaj A
MA
Pawlak
Division of Neuroimmunology, Department of Neurology, Poznan University of Medical Sciences, 49, Przybyszewskiego st., 60-355 Poznan, Poland; Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland. Electronic address: jlosy@ump.edu.pl.
Jacek
J
Losy
Department of Neurology, Poznan University of Medical Sciences, 49, Przybyszewskiego st., 60-355 Poznan, Poland. Electronic address: wkozubski@ump.edu.pl.
Wojciech
W
Kozubski
D000328:Adult; D015415:Biomarkers / Q000097:blood; D015331:Cohort Studies; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009103:Multiple Sclerosis / Q000097:blood* / Q000175:diagnosis; D009902:Optic Neuritis / Q000097:blood* / Q000175:diagnosis; D010865:Pilot Projects; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000097:blood*; D012189:Retrospective Studies; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood*; D055815:Young Adult
D015415:Biomarkers; D019408:Platelet Endothelial Cell Adhesion Molecule-1; D019010:Vascular Cell Adhesion Molecule-1
Biomarkers; Human Vascular Cell Adhesion Molecule-1 (VCAM-1); Multiple sclerosis; Neuromyelitis optica; Optic neuritis; Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1)