Rechargeable calcium phosphate orthodontic cement with sustained ion release and re-release.
White spot lesions (WSL) due to enamel demineralization are major complications for orthodontic treatments. Calcium phosphate (CaP) dental resins with Ca and P ion releases are promising for remineralization. However, previous Ca and P releases lasted for only weeks. Experimental orthodontic cements were developed using pyromellitic glycerol dimethacrylate (PMGDM) and ethoxylated bisphenol A dimethacrylate (EBPADMA) at mass ratio of 1:1 (PE); and PE plus 10% of 2-hydroxyethyl methacrylate (HEMA) and 5% of bisphenol A glycidyl dimethacrylate (BisGMA) (PEHB). Particles of amorphous calcium phosphate (ACP) were incorporated into PE and PEHB at 40% filler level. Specimens were tested for bracket-enamel shear bond strength, water sorption, CaP release, and ion recharge and re-release. PEHB+40ACP had higher bracket-enamel bond strength and ion release and rechargeability than PE+40ACP. ACP incorporation into the novel orthodontic cement did not adversely affect the bracket-enamel bond strength. Ion release and re-release from the novel ACP orthodontic cement indicated favorable release and re-release patterns. The recharged orthodontic cement could release CaP ions continuously for four weeks without further recharge. Novel rechargeable orthodontic cement containing ACP was developed with a high bracket-enamel bond strength and the ability to be repeatedly recharged to maintain long-term high levels of CaP ion releases.
State Key laboratory of Military Stomatology, Department of Prosthodontics, School of Stomatology, Fourth Military Medical University, Xi'an, 710032, China.|Department of Endodontics, Prosthodontics and Operative Dentistry, University of Maryland Dental School, Baltimore, MD 21201, USA.
Ling
L
Zhang
Department of Endodontics, Prosthodontics and Operative Dentistry, University of Maryland Dental School, Baltimore, MD 21201, USA.
Michael D
MD
Weir
Dr. Anthony Volpe Research Center, American Dental Association Foundation (ADAF), National Institute of Standards and Technology, Gaithersburg, MD 20899, USA.
Laurence C
LC
Chow
Department of Endodontics, Prosthodontics and Operative Dentistry, University of Maryland Dental School, Baltimore, MD 21201, USA.
Mark A
MA
Reynolds
Department of Endodontics, Prosthodontics and Operative Dentistry, University of Maryland Dental School, Baltimore, MD 21201, USA.|Center for Stem Cell Biology &Regenerative Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.|Department of Mechanical Engineering, University of Maryland, Baltimore County, MD 21250, USA.
Hockin H K
HH
Xu
D000327:Adsorption; D002130:Calcium Phosphates / Q000138:chemical synthesis / Q000737:chemistry*; D003738:Dental Cements / Q000138:chemical synthesis / Q000737:chemistry*; D007477:Ions / Q000378:metabolism; D033081:Shear Strength; D014867:Water / Q000737:chemistry
D002130:Calcium Phosphates; D003738:Dental Cements; D007477:Ions; C519480:amorphous calcium phosphate; D014867:Water