Selective silencing of α-globin by the histone demethylase inhibitor IOX1: a potentially new pathway for treatment of β-thalassemia.
Medical Research Council (MRC) Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, UK.|Department of Paediatrics, Faculty of Medicine, University of Kelaniya, Sri Lanka.
Sachith
S
Mettananda
Medical Research Council (MRC) Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, UK.
Christopher A
CA
Fisher
Weatherall Institute of Molecular Medicine, University of Oxford, UK.
Jackie A
JA
Sloane-Stanley
Weatherall Institute of Molecular Medicine, University of Oxford, UK.
Stephen
S
Taylor
Structural Genomics Consortium, University of Oxford, UK.|The Botnar Research Centre, NIHR BRU Oxford, University of Oxford, UK.
Udo
U
Oppermann
Medical Research Council (MRC) Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, UK.
Richard J
RJ
Gibbons
Medical Research Council (MRC) Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, UK doug.higgs@imm.ox.ac.uk liz.rose@imm.ox.ac.uk.|Oxford National Institute for Health Research Biomedical Research Centre, Blood Theme, Oxford University Hospital, UK.
Douglas R
DR
Higgs
D018952:Antigens, CD34 / Q000235:genetics / Q000378:metabolism; D020148:Butyric Acid / Q000494:pharmacology; D018929:Cell Culture Techniques; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D041905:Erythroid Cells / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D056466:Histone Demethylases / Q000037:antagonists & inhibitors / Q000235:genetics* / Q000378:metabolism; D006657:Histones / Q000235:genetics / Q000378:metabolism; D006801:Humans; D006877:Hydroxamic Acids / Q000494:pharmacology; D006912:Hydroxyquinolines / Q000494:pharmacology*; D006918:Hydroxyurea / Q000494:pharmacology; D058977:Molecular Sequence Annotation; D010879:Piperazines / Q000494:pharmacology; D034741:RNA, Small Interfering / Q000235:genetics / Q000378:metabolism; D054852:Small Molecule Libraries / Q000494:pharmacology*; D014191:Tranylcypromine / Q000494:pharmacology; D000077337:Vorinostat; D055542:alpha-Globins / Q000037:antagonists & inhibitors / Q000235:genetics* / Q000378:metabolism; D017086:beta-Thalassemia / Q000188:drug therapy / Q000201:enzymology / Q000235:genetics / Q000473:pathology
D018952:Antigens, CD34; D004791:Enzyme Inhibitors; D006657:Histones; D006877:Hydroxamic Acids; D006912:Hydroxyquinolines; D010879:Piperazines; D034741:RNA, Small Interfering; D054852:Small Molecule Libraries; D055542:alpha-Globins; D020148:Butyric Acid; C002511:chaetocin; D014191:Tranylcypromine; D000077337:Vorinostat; D056466:Histone Demethylases; C000592885:5-carboxy-8-hydroxyquinoline; D006918:Hydroxyurea