Deep analyses of the associations of a series of biomarkers with insulin resistance, metabolic syndrome, and diabetes risk in nondiabetic middle-aged and elderly individuals: results from a Chinese community-based study.
OBJECTIVE
The current study was designed to perform deep analyses of the associations of biomarkers, including high-sensitivity C-reactive protein (hs-CRP), N-terminal prohormone of brain natriuretic peptide (NT-proBNP), and homocysteine (Hcy), with insulin resistance (IR), metabolic syndrome (MetS), and diabetes risk and evaluate the abilities of biomarkers to identify IR, MetS, and diabetes risk in Chinese community-dwelling middle-aged and elderly residents.


METHODS
A total of 396 participants older than 45 years underwent physical examinations and laboratory analyses following standardized protocol.


RESULTS
Serum hs-CRP concentrations were able to identify MetS, Chinese diabetes risk score (CDRS) ≥4, high-density lipoprotein-cholesterol (HDL-c) <0.9/1.0 mmol/L, and HDL-c <1.0/1.3 mmol/L (P<0.05 for all). Serum NT-proBNP concentrations were able to identify homeostasis model assessment of IR >1.5, CDRS ≥4, overweight, and blood pressure (BP) ≥140/90 mmHg (P<0.05 for all). Serum Hcy concentrations were able to identify CDRS ≥4, general obesity, overweight, and BP ≥140/90 mmHg (P<0.05 for all). Serum hs-CRP concentrations were independently associated with MetS as well as HDL-c <1.0/1.3 mmol/L and HDL-c <0.9/1.0 mmol/L (P<0.05 for all). Serum NT-proBNP concentrations were independently associated with BP ≥140/90 mmHg (P<0.05). Serum Hcy concentrations were independently associated with CDRS ≥4 (P<0.05).


CONCLUSIONS
Serum HDL-c levels were the major determinant of the associations between serum hs-CRP levels and MetS and the key link between inflammation and MetS. There was no other association of these biomarkers with IR, MetS, and diabetes risk after full adjustment.
Department of Geriatric Cardiology; Department of Cardiology and Hainan Branch.
Shihui
S
Fu
Department of Pharmaceutical Care, Chinese People's Liberation Army General Hospital, Beijing, People's Republic of China.
Ping
P
Ping
Department of Geriatric Cardiology.
Leiming
L
Luo
Department of Geriatric Cardiology.
Ping
P
Ye
D000368:Aged; D044466:Asian People; D015415:Biomarkers; D002097:C-Reactive Protein / Q000032:analysis* / Q000096:biosynthesis; D002681:China; D008076:Cholesterol, HDL / Q000097:blood; D003920:Diabetes Mellitus / Q000097:blood; D005260:Female; D006710:Homocysteine / Q000096:biosynthesis / Q000097:blood*; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood*; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000096:biosynthesis / Q000097:blood*; D010446:Peptide Fragments / Q000096:biosynthesis / Q000097:blood*; D012306:Risk
D015415:Biomarkers; D008076:Cholesterol, HDL; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D006710:Homocysteine; D020097:Natriuretic Peptide, Brain; D002097:C-Reactive Protein
biomarkers; diabetes risk; insulin resistance; metabolic syndrome; middle-aged and elderly