A Gli(1)ttering Role for Perivascular Stem Cells in Blood Vessel Remodeling.
Blood vessels significantly remodel in response to injury and pathologic conditions, although the contribution of stem cells to this process is unclear. Now in Cell Stem Cell, Kramann et al. (2016) show that Gli1+ perivascular cells in the outermost vessel layer are progenitors that substantially contribute to pathologic vessel remodeling.
Centre for Cardiovascular Science, University of Edinburgh, Edinburgh EH16 4TJ, UK.
Andrew H
AH
Baker
Centre for Cardiovascular Science, University of Edinburgh, Edinburgh EH16 4TJ, UK; MRC, Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4UU, UK; Orthopaedic Hospital Research Center and Broad Stem Cell Center, University of California, Los Angeles, Los Angeles, CA 90024, USA. Electronic address: bpeault@mednet.ucla.edu.
Bruno
B
Péault
D006801:Humans; D020286:Pericytes; D012038:Regeneration; D013234:Stem Cells