Prognostic Importance of the Presence of Early Metabolic Response and Absence of Extrahepatic Metastasis After Selective Internal Radiation Therapy in Colorectal Cancer Liver Metastasis.
OBJECTIVE
In this study, the authors aimed to identify prognostic factors after selective internal radiation therapy (SIRT) for colorectal cancer (CRC) liver metastasis.


METHODS
Forty-nine (28 male, 21 female; mean age: 64.6 ± 10.8) patients who received SIRT for CRC liver metastasis were studied. Effects of number (<5 vs. ≥5), maximum dimension, and standardized uptake value (SUV) of liver metastases, liver tumor load (<25% vs. 26%-50% vs. 51%-75%), presence of extrahepatic disease, and metabolic early response on overall survival were analyzed.


RESULTS
Mean follow-up time was 44.1 ± 27.5 months. Overall survival time was calculated as 10.03 ± 1.61 (95% CI; 6.86-13.20) months. SUV (0.004) of liver metastases, early metabolic response (p = 0.015), and presence of extrahepatic metastasis (p = 0.001) were identified as significant factors influencing overall survival. The hazard ratio was 1:2.3 for the presence of extrahepatic metastasis and 1:2.7 for the absence of early metabolic response.


CONCLUSIONS
These findings suggest that patients with CRC liver metastasis who have lower SUV at presentation and early metabolic response have better outcomes after SIRT.
1 Department of Nuclear Medicine, Ankara University Medical School , Ankara, Turkey .
Cigdem
C
Soydal
1 Department of Nuclear Medicine, Ankara University Medical School , Ankara, Turkey .
Nuriye Ozlem
NO
Kucuk
2 Department of Surgery, Ankara University Medical School , Ankara, Turkey .
Deniz
D
Balci
2 Department of Surgery, Ankara University Medical School , Ankara, Turkey .
Ethem
E
Gecim
3 Department of Radiology, Ankara University Medical School , Ankara, Turkey .
Sadik
S
Bilgic
4 Department of Biostatistics, Ankara University Medical School , Ankara, Turkey .
Atilla Halil
AH
Elhan
D015179:Colorectal Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000532:radiotherapy*; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000032:analysis; D006801:Humans; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000532:radiotherapy* / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D000072078:Positron Emission Tomography Computed Tomography; D011379:Prognosis; D016019:Survival Analysis
D019788:Fluorodeoxyglucose F18
colorectal cancer; liver metastasis; prognostic factors; selective internal radiation therapy