Transcranial magnetic stimulation with acepromazine or dexmedetomidine in combination with levomethadone/fenpipramide in healthy Beagle dogs.
The aim of this study was to evaluate the influence of two sedation protocols on transcranial magnetic motor evoked potentials (TMMEPs) after transcranial magnetic stimulation in medium sized dogs. Onset latencies and peak-to-peak amplitudes, elicited in the extensor carpi radialis and cranial tibial muscles, were analysed in 10 healthy Beagles that received either acepromazine or dexmedetomidine in combination with levomethadone/fenpipramide, in a crossover design. Similar TMMEP recordings could be made using both sedation protocols at 80-90% stimulation intensity; however, there were significantly shorter onset latencies with the acepromazine-levomethadone/fenpipramide protocol at 100% stimulation intensity. Reference values were established and it was concluded that both drug combinations are feasible for measuring TMMEPs in medium sized dogs.
Department of Small Animal Medicine and Surgery, University of Veterinary Medicine, Hannover, Germany.
H-L
HL
Amendt
Department of Small Animal Medicine and Surgery, University of Veterinary Medicine, Hannover, Germany.
J S
JS
Siedenburg
Department of Small Animal Medicine and Surgery, University of Veterinary Medicine, Hannover, Germany.
N
N
Steffensen
Department of Small Animal Medicine and Surgery, University of Veterinary Medicine, Hannover, Germany.
F J
FJ
Söbbeler
Department of Small Animal Medicine and Surgery, University of Veterinary Medicine, Hannover, Germany.
A
A
Schütter
Department of Small Animal Medicine and Surgery, University of Veterinary Medicine, Hannover, Germany.
J
J
Tünsmeyer
Department of Biometry, Epidemiology and Information Processing, University of Veterinary Medicine, Hannover, Germany.
K
K
Rohn
Department of Small Animal Medicine and Surgery, University of Veterinary Medicine, Hannover, Germany.
S B R
SB
Kästner
Department of Small Animal Medicine and Surgery, University of Veterinary Medicine, Hannover, Germany.
A
A
Tipold
Department of Small Animal Medicine and Surgery, University of Veterinary Medicine, Hannover, Germany. Electronic address: veronika.stein@tiho-hannover.de.
V M
VM
Stein
D000075:Acepromazine / Q000494:pharmacology; D000701:Analgesics, Opioid / Q000494:pharmacology; D000818:Animals; D016292:Procedural Sedation / Q000662:veterinary*; D018592:Cross-Over Studies; D020927:Dexmedetomidine / Q000494:pharmacology; D004158:Diphenylacetic Acids / Q000494:pharmacology; D004285:Dogs; D019054:Evoked Potentials, Motor / Q000187:drug effects*; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D012016:Reference Values; D050781:Transcranial Magnetic Stimulation / Q000662:veterinary*
D000701:Analgesics, Opioid; D004158:Diphenylacetic Acids; D006993:Hypnotics and Sedatives; D000075:Acepromazine; D020927:Dexmedetomidine; C003148:fenpipramide
Acepromazine; Canine; Dexmedetomidine; Magnetic motor evoked potentials; Transcranial magnetic stimulation