Two new xanthone epimers from the processed gamboge.
Two new xanthones, gambogollic acid (1), epigambogollic acid (2), together with three rare compounds, gambogellic acid (3), epigambogellic acid (4) and gambogic acid (5), were isolated from the processed gamboge. The new structures were determined by 1D and 2D NMR spectroscopic analysis. And the cytotoxicity of these five compounds was evaluated against human hepatoma carcinoma and human lung adenocarcinoma cell. Two new compounds showed excellent antitumor activity. All five compounds exhibited inhibitory effect against SMMC-7221cell and A549 cell.
a School of Pharmacy , Nanjing University of Chinese Medicine , China.
Bang
B
Dong
a School of Pharmacy , Nanjing University of Chinese Medicine , China.
Yun-Feng
YF
Zheng
a School of Pharmacy , Nanjing University of Chinese Medicine , China.
Hong-Mei
HM
Wen
a School of Pharmacy , Nanjing University of Chinese Medicine , China.
Xin-Zhi
XZ
Wang
a School of Pharmacy , Nanjing University of Chinese Medicine , China.
Hai-Wei
HW
Xiong
a School of Pharmacy , Nanjing University of Chinese Medicine , China.
Hao
H
Wu
a School of Pharmacy , Nanjing University of Chinese Medicine , China.
Wei
W
Li
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D029760:Garcinia / Q000737:chemistry*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013056:Spectrophotometry, Ultraviolet; D044004:Xanthones / Q000737:chemistry* / Q000494:pharmacology*
D000972:Antineoplastic Agents, Phytogenic; D044004:Xanthones; C000616754:epigambogollic acid; C553741:gambogellic acid; C000616773:gambogollic acid; C052659:gambogic acid
Gamboge; cytotoxic activity; epigambogollic acid; gambogollic acid; process