Moving-source elastic wave reconstruction for high-resolution optical coherence elastography.
Optical coherence tomography (OCT)-based elasticity imaging can map soft tissue elasticity based on speckle-tracking of elastic wave propagation using highly sensitive phase measurements of OCT signals. Using a fixed elastic wave source and moving detection, current imaging sequences have difficulty in reconstructing tissue elasticity within speckle-free regions, for example, within the crystalline lens of the eye. We present a moving acoustic radiation force imaging sequence to reconstruct elastic properties within a speckle-free region by tracking elastic wave propagation from multiple laterally moving sources across the field of view. We demonstrate the proposed strategy using heterogeneous and partial speckle-free tissue-mimicking phantoms. Harder inclusions within the speckle-free region can be detected, and the contrast-to-noise ratio slightly enhanced compared to current OCE imaging sequences. The results suggest that a moving source approach may be appropriate for OCE studies within the large speckle-free regions of the crystalline lens.
University of Washington, Department of Bioengineering, 3720 15th Avenue NE, P. O. Box 355013, Seattle, Washington 98105, United StatesbChina Medical University, Department of Biomedical Imaging and Radiological Science, 91 Hsueh-Shih Road, Taichung 40402, Taiwan.
Bao-Yu
BY
Hsieh
University of Washington, Department of Bioengineering, 3720 15th Avenue NE, P. O. Box 355013, Seattle, Washington 98105, United States.
Shaozhen
S
Song
University of Washington, Department of Bioengineering, 3720 15th Avenue NE, P. O. Box 355013, Seattle, Washington 98105, United States.
Thu-Mai
TM
Nguyen
University of Washington, Department of Bioengineering, 3720 15th Avenue NE, P. O. Box 355013, Seattle, Washington 98105, United States.
Soon Joon
SJ
Yoon
University of Washington, Department of Bioengineering, 3720 15th Avenue NE, P. O. Box 355013, Seattle, Washington 98105, United StatescUniversity of Washington, Department of Ophthalmology, 325 9th Avenue, Seattle, Washington 98104, United States.
Tueng T
TT
Shen
University of Washington, Department of Bioengineering, 3720 15th Avenue NE, P. O. Box 355013, Seattle, Washington 98105, United StatescUniversity of Washington, Department of Ophthalmology, 325 9th Avenue, Seattle, Washington 98104, United States.
Ruikang K
RK
Wang
University of Washington, Department of Bioengineering, 3720 15th Avenue NE, P. O. Box 355013, Seattle, Washington 98105, United States.
Matthew
M
O'Donnell
D000818:Animals; D055119:Elastic Modulus; D054459:Elasticity Imaging Techniques / Q000379:methods*; D000882:Haplorhini; D007908:Lens, Crystalline / Q000000981:diagnostic imaging* / Q000502:physiology; D019047:Phantoms, Imaging; D041623:Tomography, Optical Coherence / Q000379:methods*