Prognostic value of hematological parameters in patients with paraquat poisoning.
Paraquat (PQ) is a non-selective contact herbicide, and acute PQ poisoning has a high mortality. The aim of the present study is to evaluate the prognostic value of hematological parameters in patients with acute PQ poisoning. We retrospectively reviewed the records of patients with acute PQ poisoning from January 2010 to December 2015 at the First Affiliated Hospital, Anhui Medical University (Hefei, China). A total of 202 patients were included in the study, and the 30-day mortality was 51.98%. Leukocyte, neutrophil counts and neutrophil-lymphocyte ratio (NLR) were significantly higher in non-survivors than in survivors. In the receiver operating characteristic (ROC) curve analysis, the NLR had an area of 0.916(95%CI, 0.877-0.954) and the optimal cut-off value was 10.57 (sensitivity, 86.70%; specificity, 83.51%; Youden's index, 0.702). The leukocyte counts had an area of 0.849(95%CI, 0.796-0.902) and the optimal cut-off value was 13.15 × 103/mm3(sensitivity, 77.10%; specificity, 83.50%; Youden's index, 0.606). The neutrophil counts had an area of 0.878(95%CI, 0.830-0.925) and the optimal cut-off value was 10.10 × 103/mm3(sensitivity, 83.80%; specificity, 79.38%; Youden's index, 0.632). NLR, leukocyte and neutrophil counts are associated with the 30-day mortality, which may be useful and simple parameters in predicting the prognosis of PQ poisoning.
Department of Emergency Medicine, the First Affiliated Hospital, Anhui Medical University, Hefei, Anhui 230022, China.
Deng-Chuan
DC
Zhou
Department of Emergency Medicine, the First Affiliated Hospital, Anhui Medical University, Hefei, Anhui 230022, China.
Hong
H
Zhang
Department of Occupational Health and Environmental Health, School of Public Health, Anhui Medical University, Hefei, Anhui 230032, China.
Zhi-Ming
ZM
Luo
Department of Occupational Health and Environmental Health, School of Public Health, Anhui Medical University, Hefei, Anhui 230032, China.|Institute of Dermatology, the First Affiliated Hospital, Anhui Medical University, Hefei, Anhui 230032, China.
Qi-Xing
QX
Zhu
Department of Occupational Health and Environmental Health, School of Public Health, Anhui Medical University, Hefei, Anhui 230032, China.
Cheng-Fan
CF
Zhou
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001773:Blood Cells; D001774:Blood Chemical Analysis; D005260:Female; D006540:Herbicides / Q000506:poisoning*; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000166:cytology / Q000187:drug effects*; D010269:Paraquat / Q000506:poisoning*; D011379:Prognosis; D012372:ROC Curve; D012189:Retrospective Studies; D055815:Young Adult
D006540:Herbicides; D010269:Paraquat