Gal3 Links Inflammation and Insulin Resistance.
The connection between obesity-induced insulin resistance and inflammation is established, but targeting inflammatory mediators like TNF-α and IL-1β have had limited success improving insulin sensitivity in patients. Now, Li et al. (2016) indicate that galectin-3 could be a targetable link between inflammation and insulin sensitivity.
Center for Systems Biology, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, MA 02114, USA; Graduate Program in Immunology, Harvard Medical School, Boston, MA 02115, USA.
Marie
M
Siwicki
Center for Systems Biology, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, MA 02114, USA; Graduate Program in Immunology, Harvard Medical School, Boston, MA 02115, USA.
Camilla
C
Engblom
Center for Systems Biology, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, MA 02114, USA. Electronic address: mpittet@mgh.harvard.edu.
Mikael J
MJ
Pittet
D006801:Humans; D007249:Inflammation; D018836:Inflammation Mediators; D007328:Insulin; D007333:Insulin Resistance; D009765:Obesity; D014409:Tumor Necrosis Factor-alpha
D018836:Inflammation Mediators; D007328:Insulin; D014409:Tumor Necrosis Factor-alpha