The metabolomics and lipidomics window into thyroid cancer research.
BACKGROUND
Thyroid carcinoma is the most common endocrine system malignancy with a fast rising incidence in the last decade for unknown reasons. Fine needle aspiration (FNA) biopsy, the gold standard in thyroid cancer (TC) screening has still its own challenges and in some cases needs a proceeding surgery.


OBJECTIVE
This review highlights the role of the two most recent "omics" approaches, "metabolomics" and "lipidomics", in the field of TC research.


METHODS
All the previous studies have been extracted from the literature and major concepts were detailed in the field of TC metabolomics and lipidomics.


RESULTS
Metabolomics and lipidomics, have potential in finding biomarkers related to thyroid carcinoma. Among the previous studies, the most important introduced altered tissue metabolites and lipids included glucose and galactose, lactate, Scyllo- and Myo inositol, hypoxanthine, citrate, cholesterol and choline.


CONCLUSIONS
Metabolomics methods have been widely used in the field of biomarker discovery in TC and attempts are still in progress to use these methods to find a reliable biomarker panel besides current diagnostic tools.
a Proteomics Research Center, Faculty of Paramedical Sciences , Shahid Beheshti University of Medical Sciences , Tehran , Iran.
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R
Farrokhi Yekta
a Proteomics Research Center, Faculty of Paramedical Sciences , Shahid Beheshti University of Medical Sciences , Tehran , Iran.
M
M
Rezaie Tavirani
b Department of Basic Sciences, Faculty of Paramedical Sciences , Shahid Beheshti University of Medical Sciences , Tehran , Iran.
A
A
Arefi Oskouie
c Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute , Tehran University of Medical Sciences , Tehran , Iran.
M R
MR
Mohajeri-Tehrani
d Department of Surgery , Shariati Hospital, Tehran University of Medical Sciences , Tehran , Iran.
A R
AR
Soroush
D015415:Biomarkers; D006801:Humans; D008055:Lipids / Q000032:analysis*; D055432:Metabolomics / Q000379:methods*; D013964:Thyroid Neoplasms / Q000737:chemistry / Q000175:diagnosis* / Q000378:metabolism*
D015415:Biomarkers; D008055:Lipids
Metabolomics; biomarker discovery; lipidomics; thyroid cancer