Vasomotor regulation in patients with multiple system atrophy.
To investigate the vasomotor regulation in multiple system atrophy (MSA), we simultaneously recorded muscle sympathetic nerve activity (MSNA), heart rate, and blood pressure in 14 MSA patients without syncope and 18 healthy subjects. Resting MSNA bursts were significantly less frequent in MSA patients than healthy subjects (p < 0.001), while the increase of MSNA bursts with head-up tilt was significantly greater in MSA patients (p < 0.01). In patients with MSA, orthostatic hypotension may be prevented by an augmented MSNA response.
Department of Neurology, University of Yamanashi, 1110 Shimokato, Chuo-City, Yamanashi, 409-3898, Japan. kshindo@yamanashi.ac.jp.
Kazumasa
K
Shindo
Department of Neurology, University of Yamanashi, 1110 Shimokato, Chuo-City, Yamanashi, 409-3898, Japan.
Mai
M
Tsuchiya
Department of Neurology, University of Yamanashi, 1110 Shimokato, Chuo-City, Yamanashi, 409-3898, Japan.
Yuta
Y
Ichinose
Department of Neurology, University of Yamanashi, 1110 Shimokato, Chuo-City, Yamanashi, 409-3898, Japan.
Kishin
K
Koh
Department of Neurology, University of Yamanashi, 1110 Shimokato, Chuo-City, Yamanashi, 409-3898, Japan.
Takanori
T
Hata
Department of Neurology, University of Yamanashi, 1110 Shimokato, Chuo-City, Yamanashi, 409-3898, Japan.
Nobuo
N
Yamashiro
Department of Neurology, University of Yamanashi, 1110 Shimokato, Chuo-City, Yamanashi, 409-3898, Japan.
Fumikazu
F
Kobayashi
Department of Neurology, University of Yamanashi, 1110 Shimokato, Chuo-City, Yamanashi, 409-3898, Japan.
Takamura
T
Nagasaka
Department of Neurology, University of Yamanashi, 1110 Shimokato, Chuo-City, Yamanashi, 409-3898, Japan.
Yoshihisa
Y
Takiyama
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001794:Blood Pressure / Q000502:physiology*; D001795:Blood Pressure Determination; D004562:Electrocardiography; D005260:Female; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D007024:Hypotension, Orthostatic / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D019578:Multiple System Atrophy / Q000503:physiopathology*; D009132:Muscles / Q000503:physiopathology; D012146:Rest; D013564:Sympathetic Nervous System / Q000503:physiopathology*
Blood pressure; Multiple system atrophy; Muscle sympathetic nerve activity; Orthostatic hypotension; Vasomotor regulation