DNA Polymerase Fidelity: Beyond Right and Wrong.
Accurate DNA replication depends on the ability of DNA polymerases to discriminate between correctly and incorrectly paired nucleotides. In this issue of Structure, Batra et al. (2016) show the structural basis for why DNA polymerases do not efficiently add correctly paired nucleotides immediately after incorporating incorrectly paired ones.
Department of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA. Electronic address: todd-washington@uiowa.edu.
M Todd
MT
Washington
D004247:DNA / Q000235:genetics; D004261:DNA Replication; D004259:DNA-Directed DNA Polymerase / Q000737:chemistry*; D009711:Nucleotides / Q000737:chemistry
D009711:Nucleotides; D004247:DNA; D004259:DNA-Directed DNA Polymerase