Tissue-Specific Regulation of the Contents and Correlations of Mineral Elements in Hens by Zinc Oxide Nanoparticles.
Due to their small size, zinc oxide (ZnO) nanoparticles (NPs) are readily absorbed and easily cross biological barriers, which make them promising candidates as diet additives. However, some studies have reported that ZnO NPs cause toxicity; therefore, their safety and potency as diet additives for farm animals should be established. This study was the first to fully evaluate the effects of ZnO NPs on the homeostasis of eight elements in seven organs/tissues. The regulation of element homeostasis was found to be organ specific with no influence on oxidation status, anti-oxidation capability, or organ damage. ZnO NPs may specifically regulate the homeostasis of mineral elements and affect the following correlations: (1) between the element content in each organ and the concentration of Zn used in ZnSO4or ZnO NP treatments; (2) between ZnO NP and ZnSO4treatments for the same element in each organ; and (3) between elements (in each organ in ZnSO4or ZnO NP treatments) in layers' organs/tissues. The use of ZnO NPs as diet additives for animals should be implemented cautiously because, among other uncertainties, they may affect mineral element content.
College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao, 266109, People's Republic of China.|Key Laboratory of Animal Reproduction and Germplasm Enhancement in Universities of Shandong, Qingdao, 266109, People's Republic of China.
Yong
Y
Zhao
Key Laboratory of Animal Reproduction and Germplasm Enhancement in Universities of Shandong, Qingdao, 266109, People's Republic of China.
Yan-Ni
YN
Feng
Key Laboratory of Animal Reproduction and Germplasm Enhancement in Universities of Shandong, Qingdao, 266109, People's Republic of China.
Lan
L
Li
State Key Laboratory of Animal Nutrition, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, 100193, People's Republic of China.
Hong-Fu
HF
Zhang
Core Laboratories of Qingdao Agricultural University, Qingdao, 266109, People's Republic of China.
Yu-Na
YN
Zhang
College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao, 266109, People's Republic of China.|Key Laboratory of Animal Reproduction and Germplasm Enhancement in Universities of Shandong, Qingdao, 266109, People's Republic of China.
Peng-Fei
PF
Zhang
College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao, 266109, People's Republic of China.
Xin-Qi
XQ
Liu
College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao, 266109, People's Republic of China.|Key Laboratory of Animal Reproduction and Germplasm Enhancement in Universities of Shandong, Qingdao, 266109, People's Republic of China.
Wei-Dong
WD
Zhang
College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao, 266109, People's Republic of China.
Ting-Ting
TT
Huang
College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao, 266109, People's Republic of China.
Li
L
Zhao
Key Laboratory of Animal Reproduction and Germplasm Enhancement in Universities of Shandong, Qingdao, 266109, People's Republic of China.
Wei
W
Shen
College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao, 266109, People's Republic of China. zHao6276@hotmail.com.
Zhi-Hui
ZH
Hao
D000818:Animals; D002645:Chickens / Q000378:metabolism*; D006706:Homeostasis / Q000187:drug effects; D008903:Minerals / Q000032:analysis / Q000378:metabolism* / Q000493:pharmacokinetics; D053758:Nanoparticles / Q000032:analysis*; D014018:Tissue Distribution; D014131:Trace Elements / Q000032:analysis / Q000378:metabolism* / Q000493:pharmacokinetics; D015034:Zinc Oxide / Q000032:analysis / Q000494:pharmacology*
D008903:Minerals; D014131:Trace Elements; D015034:Zinc Oxide
Correlations; Elements; Hens; Homeostasis; Zinc oxide nanoparticles