Genetic variants in TERT are associated with risk of gastric cancer in a Chinese Han population.
Telomerase reverse transcriptase (TERT) is a gene within the cancer susceptibility region located at Chr5p15.33, which is associated with multiple cancer types. In this study, we validated the association between TERT polymorphisms and gastric cancer (GC) risk with a case-control study in a Chinese Han population. A total of 302 GC patients and 300 control individuals were recruited. We identified three single nucleotide polymorphisms (SNPs) in TERT that were associated with GC. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated in logistic regression models after adjusting for age and gender to assess the association. The minor alleles of three SNPs were associated with increased GC risk inallelic model analysis. For two of the SNPs, rs10069690 and rs2853676,, the dominant and additive model frequencies were higher in GC cases compared to controls. Further haplotype analysis revealed a protective effect of haplotype ''CG'' of the TERT gene, while the haplotype "TA" increased GC risk.Our resultsprovide new evidence for the association between TERT and GC susceptibility in the Chinese Han population.
Department of the Second General Surgery, Shaanxi Provincial People's Hospital, Xi'an 710068, China.
Xianglong
X
Duan
Department of Oncological Surgery, Shaanxi Provincial People's Hospital, Xi'an 710068, China.
Wei
W
Cao
Department of Respiratory Medicine, Chinese PLA General Hospital, Beijing 100853, China.
Lijie
L
Wang
Department of the Second General Surgery, Shaanxi Provincial People's Hospital, Xi'an 710068, China.
Sida
S
Liu
Department of Surgery, Xi'an Chest Hospital, Xi'an TB&Thoracic Tumor Hospital, Xi'an 710100, China.
Zhao
Z
Liu
Graduate School of Inner Mongolia Medical University, Hohhot 010030, China.
Bolun
B
Zhang
Xi'an Tiangen Precision Medical Institute, Xi'an, Shaanxi 710075, China.
Hua
H
Yang
Xi'an Tiangen Precision Medical Institute, Xi'an, Shaanxi 710075, China.
Tian
T
Feng
School of Life Sciences, Northwest University, Xi'an 710069, China.
Jiayi
J
Zhang
School of Life Sciences, Northwest University, Xi'an 710069, China.
Xiyang
X
Zhang
Department of the Second General Surgery, Shaanxi Provincial People's Hospital, Xi'an 710068, China.
Yanbin
Y
Long
Xi'an Tiangen Precision Medical Institute, Xi'an, Shaanxi 710075, China.|School of Life Sciences, Northwest University, Xi'an 710069, China.|Key Laboratory of Molecular Mechanism and Intervention Research for Plateau Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi 712082, China.
Tianbo
T
Jin
D000368:Aged; D044466:Asian People / Q000235:genetics; D014408:Biomarkers, Tumor / Q000235:genetics*; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002681:China; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D015810:Linkage Disequilibrium; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000201:enzymology / Q000208:ethnology / Q000235:genetics* / Q000473:pathology; D019098:Telomerase / Q000235:genetics*
D014408:Biomarkers, Tumor; C509186:TERT protein, human; D019098:Telomerase
gastric cancer (GC); single nucleotide polymorphisms (SNP); telomerase reverse transcriptase (TERT)