Advances in biodegradable nanomaterials for photothermal therapy of cancer.
Photothermal cancer therapy is an alternative to chemotherapy, radiotherapy, and surgery. With the development of nanophotothermal agents, this therapy holds immense potential in clinical translation. However, the toxicity issues derived from the fact that nanomaterials are trapped and retained in the reticuloendothelial systems limit their biomedical application. Developing biodegradable photothermal agents is the most practical route to address these concerns. In addition to the physicochemical properties of nanomaterials, various internal and external stimuli play key roles on nanomaterials uptake, transport, and clearance. In this review, we summarized novel nanoplatforms for photothermal therapy; these nanoplatforms can elicit stimuli-triggered degradation. We focused on the recent innovative designs endowed with biodegradable photothermal agents under different stimuli, including enzyme, pH, and near-infrared (NIR) laser.
School of Material Science and Engineering, Henan Polytechnic University, Jiaozuo 454000, China; Beijing Key Laboratory of Bioprocess, Beijing University of Chemical Technology, Beijing 100029, China.
Chao-Feng
CF
He
Beijing Key Laboratory of Bioprocess, Beijing University of Chemical Technology, Beijing 100029, China.
Shun-Hao
SH
Wang
Department of Materials Science and Engineering, State University of New York at Stony Brook, Stony Brook, NY 11790, USA.
Ying-Jie
YJ
Yu
Beijing Key Laboratory of Bioprocess, Beijing University of Chemical Technology, Beijing 100029, China.
He-Yun
HY
Shen
Department of Emergency, Shandong Heze Municipal Hospital, Heze 274031, China.
Yan
Y
Zhao
Beijing Key Laboratory of Bioprocess, Beijing University of Chemical Technology, Beijing 100029, China.
Hui-Ling
HL
Gao
CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology (NCNST), Beijing 100190, China.
Hai
H
Wang
Beijing Institute of Nanoenergy and Nanosystems, National Center for Nanoscience and Technology (NCNST), Chinese Academy of Sciences, Beijing 100083, China.
Lin-Lin
LL
Li
Beijing Key Laboratory of Bioprocess, Beijing University of Chemical Technology, Beijing 100029, China.
Hui-Yu
HY
Liu
Photothermal therapy; biodegradability; enzyme stimuli; near-infrared laser stimuli; pH stimuli