Statistical analysis of the relationship between IL-10 gene promoter polymorphisms and the development of coronary artery disease.
Here, we conducted a case-control study to investigate the association between IL-10 gene polymorphisms and development of CAD in a Chinese population. A total of 220 patients with CAD and 236 control subjects who visited the Zhengzhou People's Hospital between May 2012 and June 2014 were selected for this study. The IL-10-1082A/G and -592A/C polymorphisms were genotyped by polymerase chain reaction coupled with restriction fragment length polymorphism. The chi-squared test revealed a significant difference in the distributions of the IL-10-1082A/G genotypes (χ2= 6.32, P = 0.04). This data was then statistically analyzed by logistic regression analysis; we observed revealed that the CC genotype of IL-10-1082A/G had a higher risk of CAD in comparison to the AA genotype (OR = 2.09, 95%CI = 1.11-3.97). Moreover, the C allele of IL-10-1082A/G had a 1.39 fold risk of CAD when compared with (OR = 1.39, 95%CI = 1.06-1.82). We did not observe any significant correlations between the IL-10-592A/C genetic variation and susceptibility to CAD. In conclusion, our study suggests that the IL-10-1082A/G genetic variation could influence the development of CAD in a Chinese population.
Department of Cardiology, Zhengzhou People's Hospital, Zhengzhou, Henan, China.
L
L
Wu
Department of Cardiology, Zhengzhou People's Hospital, Zhengzhou, Henan, China.
M H
MH
Zhao
Department of Cardiology, Zhengzhou People's Hospital, Zhengzhou, Henan, China.
G Y
GY
Geng
Department of Cardiology, Zhengzhou People's Hospital, Zhengzhou, Henan, China.
L
L
Mao
Department of Cardiology, Zhengzhou People's Hospital, Zhengzhou, Henan, China.
H J
HJ
Liu
D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011401:Promoter Regions, Genetic; D013223:Statistics as Topic
C508609:IL10 protein, human; D016753:Interleukin-10