Glucose Metabolism and Its Complicated Relationship with Tumor Growth and Perfusion in Head and Neck Squamous Cell Carcinoma.
OBJECTIVE
To determine the relationship between tumor glucose metabolism and tumor blood flow (TBF) in head and neck squamous cell carcinoma (HNSCC).


METHODS
We retrospectively analyzed 57 HNSCC patients. Tumor glucose metabolism was assessed by maximum and mean standardized uptake values (SUVmax and SUVmean) obtained by 18F-fluorodeoxyglucose positron-emission tomography. TBF values were obtained by arterial spin labeling with 3-tesla MRI. The correlations between both SUVs and TBF were assessed in the total series and among patients divided by T-stage (T1-T3 and T4 groups) and tumor location (pharynx/oral cavity and sinonasal cavity groups). Pearson's correlation coefficients were calculated for significant correlations.


RESULTS
Significant correlations were detected: a negative correlation in the advanced T-stage group (TBF and SUV max: r, -0.61, SUVmean: r, -0.62), a positive correlation in the non-advanced T-stage pharynx/oral cavity group (TBF and SUVmax: r, 0.70, SUVmean: r, 0.73), a negative correlation in the advanced T-stage pharynx/oral cavity group (TBF and SUVmax: r, -0.62, SUVmean: r, -0.65), and a negative correlation in the advanced T-stage sinonasal cavity group (TBF and SUVmax: r, -0.61, SUVmean: r, -0.65).


CONCLUSIONS
Significant correlations between glucose uptake and TBF in HNSCC were revealed by the division of T-stage and tumor location.
Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, Japan.
Noriyuki
http://orcid.org/0000-0001-9021-347X
N
Fujima
Department of Otolaryngology-Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Tomohiro
T
Sakashita
Department of Otolaryngology-Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Akihiro
A
Homma
Department of Nuclear Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Kenji
K
Hirata
Department of Nuclear Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Tohru
T
Shiga
Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, Japan.
Kohsuke
K
Kudo
Department of Radiation Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan.|The Global Station for Quantum Medical Science and Engineering, Global Institution for collaborative research and education, Sapporo, Japan.
Hiroki
H
Shirato
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology*; D049109:Cell Proliferation / Q000502:physiology*; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000008:administration & dosage; D005947:Glucose / Q000378:metabolism*; D006258:Head and Neck Neoplasms / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging / Q000379:methods; D010477:Perfusion / Q000379:methods; D049268:Positron-Emission Tomography / Q000379:methods; D019275:Radiopharmaceuticals / Q000008:administration & dosage; D012189:Retrospective Studies; D013113:Spin Labels; D000077195:Squamous Cell Carcinoma of Head and Neck
D019275:Radiopharmaceuticals; D013113:Spin Labels; D019788:Fluorodeoxyglucose F18; D005947:Glucose