TLR signalling and association of TLR polymorphism with cardiovascular diseases.
Toll-Like receptors (TLRs) are the primary receptors of innate immunity. Considerable evidences have shown that innate immune defence interaction with pro-inflammatory pathways could be through TLRs that in turn leads to development of inflammatory diseases. These TLRs are present on various tissues and cells of cardiovascular system. Previous studies involving SNPs analysis of TLRs demonstrated that TLRs are involved in development and progression of diseases like atherosclerosis, cardiac dysfunction in sepsis and congestive heart failure. In this review, we aimed to bring together the studies which have been conducted previously to establish a link between TLR polymorphism in context to development of cardiovascular diseases (CVD).
Department of Genomics, Defence Institute of Physiology and Allied Sciences (DIPAS), Delhi, India.
Swati
S
Sharma
Department of Genomics, Defence Institute of Physiology and Allied Sciences (DIPAS), Delhi, India. Electronic address: iti219@gmail.com.
Iti
I
Garg
Department of Genomics, Defence Institute of Physiology and Allied Sciences (DIPAS), Delhi, India.
Mohammad Z
MZ
Ashraf
D000818:Animals; D002318:Cardiovascular Diseases / Q000235:genetics / Q000276:immunology / Q000503:physiopathology*; D018450:Disease Progression; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology; D007249:Inflammation / Q000235:genetics / Q000276:immunology / Q000503:physiopathology*; D020641:Polymorphism, Single Nucleotide; D015398:Signal Transduction / Q000276:immunology; D051193:Toll-Like Receptors / Q000235:genetics / Q000276:immunology*
D051193:Toll-Like Receptors
Atherosclerosis; Cardiovascular diseases; TLR polymorphism; Toll-like receptors (TLRs)