Norovirus in benign convulsions with mild gastroenteritis.
BACKGROUND
Benign convulsions with gastroenteritis (CwG) are defined as afebrile convulsions accompanying symptoms of gastroenteritis without evidence of laboratory derangement. Although the main pathogen has been known as rotavirus, since the introduction of rotavirus vaccine, associated viruses with CwG may have changed. Thus, we evaluated the viral association of CwG for patients admitting for recent 2.5 years.


METHODS
All patients hospitalized for CwG between November 2012 and May 2015 were included in our study. Stool specimens were tested with reverse transcription polymerase chain reaction for detecting norovirus and astrovirus and with enzyme immunoassay for rotavirus and enteric adenovirus. Clinical data was gathered via chart review.


RESULTS
Fifty patients were included. Except four patients who failed to collect stool samples, 46 patients were tested. Causative diarrheal viruses were detected in 38 patients and they were 29 norovirus, four rotavirus, four adenovirus, and one astrovirus. Norovirus was commonly identified during the months of November and December. No difference of the clinical characteristics and laboratory value was noted according to the number of seizure episodes.


CONCLUSIONS
Norovirus is a common pathogen in CwG. Understanding the viral associations can facilitate recognition of CwG.
Department of Pediatrics, Korea University College of Medicine, Seoul, South Korea.
Gun-Ha
GH
Kim
Department of Pediatrics, Korea University College of Medicine, Seoul, South Korea.
Jung Hye
JH
Byeon
Division of Enteric Diseases, Center for Infectious Disease, National Institute of Health, Korea Center for Disease Control & Prevention (CDC-Korea), Chungcheongbuk-do, South Korea.
Deog-Yong
DY
Lee
Division of Enteric Diseases, Center for Infectious Disease, National Institute of Health, Korea Center for Disease Control & Prevention (CDC-Korea), Chungcheongbuk-do, South Korea.
Hyun Ju
HJ
Jeong
Department of Pediatrics, Korea University College of Medicine, Seoul, South Korea. bleun@korea.ac.kr.|Department of Pediatrics, Korea University Guro Hospital, 148, Gurodong-ro, Guro-gu, Seoul, 08308, South Korea. bleun@korea.ac.kr.
Baik-Lin
BL
Eun
D017250:Caliciviridae Infections / Q000175:diagnosis*; D004569:Electroencephalography; D005243:Feces / Q000821:virology; D005260:Female; D005759:Gastroenteritis / Q000821:virology*; D006801:Humans; D007223:Infant; D008297:Male; D029322:Norovirus / Q000302:isolation & purification*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012640:Seizures / Q000821:virology*
Gastroenteritis; Norovirus; Pediatric; Seizures