[Protein complexes coordinating mRNA export from the nucleus into the cytoplasm].
The molecular mechanisms that coordinate transcription, processing, mRNP assembly, and mRNA export from the nucleus through nuclear pores into the cytoplasm have been the focus of intense research in recent years. Data demonstrating a tight association between the processes involved in gene expression are considered. The main protein complexes that play a role in mRNA export are described. The complexes are recruited to mRNA at steps preceding the mRNA export. The functions that the complexes perform at particular steps of gene expression are analyzed, and protein complexes responsible for quality control of mRNP discussed.
Institute of Gene Biology, Russian Academy of Sciences, Moscow, 119334 Russia.|kursha@mail.ru.
M M
MM
Kurshakova
Institute of Gene Biology, Russian Academy of Sciences, Moscow, 119334 Russia.
S G
SG
Georgieva
Institute of Gene Biology, Russian Academy of Sciences, Moscow, 119334 Russia.
D V
DV
Kopytova
D021581:Active Transport, Cell Nucleus / Q000502:physiology; D000818:Animals; D002467:Cell Nucleus / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D046912:Multiprotein Complexes / Q000235:genetics / Q000378:metabolism*; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism*
D046912:Multiprotein Complexes; D009687:Nuclear Proteins; D012333:RNA, Messenger
NPC; THO; TREX-2; mRNA; mRNA export; mRNP