Is age at puberty associated with semen quality and reproductive hormones in young adult life?
The evidence is scarce on the association between age at puberty and semen quality. A cohort of 320 Danish men aged 18-21 years enrolled in the "Healthy Habits for Two" birth cohort provided self-reported data on pubertal indicators and delivered semen and blood samples. The results indicated an association between older age at pubertal development and lower semen quality and altered reproductive hormones concentrations as measured in young adult life. Men who had their first nocturnal emission, start of pubic hair growth and first voice break episode when older than 15 years had 37.0%, 45.0% and 32.7% lower sperm concentration; 37.8%, 44.2% and 29.1% lower total sperm count; 7.4%, 13.4% and 15.3% lower testosterone concentration; and 21.3%, 1.5% and 3.7% lower inhibin B concentration, respectively, compared with the men who were younger than 13 years at their first pubertal indicators. Only few of the results were statistically significant, but similar tendencies were seen in several of the reproductive parameters suggesting an association between the timing of pubertal development and reproductive health later in life.
Department of Public Health, Section for Epidemiology, Aarhus University, 8000 Aarhus C, Denmark.
Lea Lb
LL
Lauridsen
Department of Public Health, Section for Epidemiology, Aarhus University, 8000 Aarhus C, Denmark.
Linn H
LH
Arendt
Department of Public Health, Section for Biostatistics, Aarhus University, 8000 Aarhus C, Denmark.
Henrik
H
Støvring
Department of Clinical Epidemiology, Aarhus University Hospital, 8200 Aarhus N, Denmark.
Jørn
J
Olsen
Department of Public Health, Section for Epidemiology, Aarhus University, 8000 Aarhus C, Denmark.
Cecilia H
CH
Ramlau-Hansen
D000293:Adolescent; D000367:Age Factors; D002648:Child; D006801:Humans; D007265:Inhibins / Q000097:blood*; D008297:Male; D011627:Puberty / Q000502:physiology*; D055101:Semen Analysis; D013076:Sperm Count; D013081:Sperm Motility; D013094:Spermatozoa / Q000502:physiology*; D013739:Testosterone / Q000097:blood*; D055815:Young Adult
C422364:inhibin B; D013739:Testosterone; D007265:Inhibins