Differential regenerative ability of sensory and motor neurons.
After injury, the adult mammalian central nervous system (CNS) lacks long-distance axon regeneration. This review discusses the similarities and differences of sensory and motor neurons, seeking to understand how to achieve functional sensory and motor regeneration. As these two types of neurons respond differently to axotomy, growth environment and treatment, the future challenge will be on how to achieve full recovery in a way that allows regeneration of both types of fibres simultaneously.
John van Geest Centre for Brain Repair, University of Cambridge, Cambridge CB2 0PY, United Kingdom.
Menghon
M
Cheah
John van Geest Centre for Brain Repair, University of Cambridge, Cambridge CB2 0PY, United Kingdom. Electronic address: jf108@cam.ac.uk.
James W
JW
Fawcett
John van Geest Centre for Brain Repair, University of Cambridge, Cambridge CB2 0PY, United Kingdom. Electronic address: bh432@cam.ac.uk.
Barbara
B
Haenzi
D000818:Animals; D001369:Axons / Q000502:physiology; D005347:Fibroblasts / Q000637:transplantation; D006801:Humans; D009046:Motor Neurons / Q000378:metabolism / Q000473:pathology / Q000502:physiology*; D011984:Sensory Receptor Cells / Q000378:metabolism / Q000473:pathology / Q000502:physiology*; D015398:Signal Transduction; D013116:Spinal Cord / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology; D013119:Spinal Cord Injuries / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology / Q000628:therapy; D058630:Spinal Cord Regeneration; D014158:Transcription, Genetic
Grafts; Motor neurons; Regeneration; Sensory neurons; Spinal cord