Genomic Microarray in Fetuses with Early Growth Restriction: A Multicenter Study.
BACKGROUND
Little information is available about the risk of microdeletion and microduplication syndromes in fetal growth restriction (FGR) with a normal karyotype.


OBJECTIVE
To assess the incremental yield of genomic microarray over conventional karyotyping in fetuses with early growth restriction.


METHODS
Genomic microarray was prospectively performed in fetuses with early growth restriction defined as a fetal weight below the 3rd percentile estimated before 32 weeks of pregnancy, and a normal quantitative fluorescent polymerase chain reaction result. The incremental yield of genomic microarray was defined by the rate of fetuses presenting with a pathogenic copy number variant below 10 Mb.


RESULTS
Among 133 fetuses with early FGR, a 6.8% (95% CI: 2.5-11.0) incremental yield of genomic microarray over karyotyping was observed. This incremental yield was 4.8% (95% CI: 0.2-9.3) in isolated FGR, 10% (95% CI: 0-20.7) in FGR with nonstructural anomalies, and 10.5% (95% CI: 0-24.3) in FGR with structural anomalies.


CONCLUSIONS
Our multicenter study reveals that 6.8% of fetuses with early growth restriction present with submicroscopic anomalies after common aneuploidies were excluded. Even when FGR is observed as an isolated finding, genomic microarray analysis should be considered after or instead of karyotyping, due to its 4.8% incremental yield.
BCNatal, Hospital Clínic de Barcelona, Barcelona, Spain.
Antoni
A
Borrell
Maribel
M
Grande
Eva
E
Meler
Joan
J
Sabrià
Edurne
E
Mazarico
Anna
A
Muñoz
Laia
L
Rodriguez-Revenga
Cèlia
C
Badenas
Francesc
F
Figueras
D002869:Chromosome Aberrations; D005260:Female; D047109:Fetal Development / Q000235:genetics; D005317:Fetal Growth Retardation / Q000235:genetics*; D023281:Genomics; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis; D011247:Pregnancy; D011256:Pregnancy Outcome
Copy number variants; Fetal growth restriction; Genomic microarray; Prenatal diagnosis