Highly oxidized sesquiterpenes from Artemisia austro-yunnanensis.
Eight new sesquiterpenes, including four guaianolides (1-4), one guaian sesquiterpene (5), one norguaianolide (6), one 1, 10-secoguaianolides (7), and one eudesmane sesquiterpene (8), along with fourteen known sesquiterpenes (9-22) were isolated from the whole plants of Artemisia austro-yunnanensis. Their structures were elucidated on the basis of spectroscopic date and HRESIMS analysis. All isolated sesquiterpenes (1-22) were evaluated their activities by the assay of LPS-induced NO production on RAW264.7, of which compounds 2-4, 9, 10 and 17 produced significant inhibition of NO production with IC50values ranging from 2.38 to 10.67μM.
Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China.
Jun
J
Chi
Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China.
Bao-Cai
BC
Li
Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China.
Wei-Feng
WF
Dai
Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China.
Lan
L
Liu
Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China. Electronic address: mizhangkmust@126.com.
Mi
M
Zhang
D000818:Animals; D019306:Artemisia / Q000737:chemistry*; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000378:metabolism; D010936:Plant Extracts / Q000737:chemistry; D000067996:RAW 264.7 Cells; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification
D010936:Plant Extracts; D012717:Sesquiterpenes; D009569:Nitric Oxide
Artemisia austro-yunnanensis; Guaianolide; Inhibition of NO production; Sesquiterpene