Antibody therapeutics for treating prostate cancer: where are we now and what comes next?
Progress in the understanding of molecular events of carcinogenesis and cancer evolution as well as the identification of tumor antigens has led to the development of different targeted therapeutic approaches, including the use of monoclonal antibodies (mAbs). Prostate cancer (PC) is highly amenable to mAb targeting given the existence of prostate-specific targets and the natural history and localization of metastatic disease. Areas covered: Several aspects of the PC phenotype, including growth factors, angiogenesis mediators, bone microenvironment signals, and immune evasion pathways, have become areas of ongoing investigation in terms of mAb targeting. These are reviewed. The greatest success so far has been the development of mAbs against prostate-specific tumor antigen (PSMA), which opened an opportunity to improve diagnostic accuracy and simultaneously target metastatic disease. Expert opinion: As mAb use in PC continues to evolve, more accurate imaging of the extent of disease and more effective mAb therapies (naked or conjugated with drugs, toxins or radioactive molecules) are emerging. In addition, the combination of mAbs with other treatment modalities is expected to further improve responses and overall survival. Identification of validated biomarkers is necessary for better recognition of patient subgroups who will derive the greatest benefit from mAb therapy.
a Division of Hematology and Medical Oncology , Weill Cornell Medicine , New York , NY , USA.
Panagiotis J
PJ
Vlachostergios
a Division of Hematology and Medical Oncology , Weill Cornell Medicine , New York , NY , USA.|b Meyer Cancer Center , Weill Cornell Medicine , New York , NY , USA.
Giuseppe
G
Galletti
a Division of Hematology and Medical Oncology , Weill Cornell Medicine , New York , NY , USA.
Jessica
J
Palmer
a Division of Hematology and Medical Oncology , Weill Cornell Medicine , New York , NY , USA.
Linda
L
Lam
a Division of Hematology and Medical Oncology , Weill Cornell Medicine , New York , NY , USA.
Beerinder S
BS
Karir
a Division of Hematology and Medical Oncology , Weill Cornell Medicine , New York , NY , USA.|b Meyer Cancer Center , Weill Cornell Medicine , New York , NY , USA.|c Department of Urology , Weill Cornell Medicine , New York , NY , USA.
Scott T
ST
Tagawa
D000818:Animals; D000911:Antibodies, Monoclonal / Q000008:administration & dosage* / Q000276:immunology; D000951:Antigens, Neoplasm / Q000276:immunology / Q000378:metabolism; D000954:Antigens, Surface / Q000276:immunology / Q000378:metabolism; D016503:Drug Delivery Systems / Q000379:methods; D043425:Glutamate Carboxypeptidase II / Q000037:antagonists & inhibitors / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007610:Kallikreins / Q000037:antagonists & inhibitors* / Q000276:immunology / Q000378:metabolism; D008297:Male; D009389:Neovascularization, Pathologic / Q000188:drug therapy / Q000378:metabolism; D017430:Prostate-Specific Antigen / Q000037:antagonists & inhibitors* / Q000276:immunology / Q000378:metabolism; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000276:immunology / Q000378:metabolism; D016896:Treatment Outcome
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D000954:Antigens, Surface; D043425:Glutamate Carboxypeptidase II; C549870:KLK3 protein, human; D007610:Kallikreins; D017430:Prostate-Specific Antigen
Immunotherapy; monoclonal antibody; prostate cancer; prostate-specific membrane antigen; targeted therapy