Early Life Fructose Exposure and Its Implications for Long-Term Cardiometabolic Health in Offspring.
It has become increasingly clear that maternal nutrition can strongly influence the susceptibility of adult offspring to cardiometabolic disease. For decades, it has been thought that excessive intake of fructose, such as sugar-sweetened beverages and foods, has been linked to increased risk of obesity, type 2 diabetes, and cardiovascular disease in various populations. These deleterious effects of excess fructose consumption in adults are well researched, but limited data are available on the long-term effects of high fructose exposure during gestation, lactation, and infancy. This review aims to examine the evidence linking early life fructose exposure during critical periods of development and its implications for long-term cardiometabolic health in offspring.
Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Diabetes Research Center of Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China. zhengjiapumc@163.com.
Jia
J
Zheng
Department of Pediatrics, The Second Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China. fengqianyun@yahoo.com.
Qianyun
Q
Feng
Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Diabetes Research Center of Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China. rubiacordifolia@yahoo.com.
Qian
Q
Zhang
Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Diabetes Research Center of Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China. tongtong0716@sina.com.
Tong
T
Wang
Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Diabetes Research Center of Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China. xiaoxinhua@medmail.com.cn.
Xinhua
X
Xiao
D003924:Diabetes Mellitus, Type 2 / Q000209:etiology*; D005260:Female; D005632:Fructose / Q000008:administration & dosage* / Q000009:adverse effects*; D006801:Humans; D039382:Maternal Nutritional Physiological Phenomena; D009765:Obesity / Q000209:etiology*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012307:Risk Factors
D005632:Fructose
cardiometabolic health; early life; fructose; offspring; sugar-sweetened beverages