Composite Blastoid Variant of Mantle Cell Lymphoma and Classical Hodgkin Lymphoma.
Composite lymphoma (CL) describes the rare occurrence of 2 or more distinct types of lymphoma in a single anatomical location. We present the case of a 78-year-old man presenting with a 3-month history of weakness, malaise, and increasing dyspnea. A lymph node excised from the posterior triangle of the neck revealed the coexistence of 2 morphologically and phenotypically distinct lymphoid neoplasms consistent with a blastoid variant of mantle cell lymphoma (MCL) occurring in composite with classical Hodgkin lymphoma (cHL), mixed cellularity subtype. A t(11;14)(q13;q32) translocation was demonstrated by fluorescence in situ hybridization in the MCL and Hodgkin Reed-Sternberg cells of the cHL. Multiplex polymerase chain reaction detected clonal Immunoglobulin heavy chain (VFR1-J, VFR2-J, and VFR3-J), clonal immunoglobulin light chain kappa (V-J and V/JC intron-kde) and clonal immunoglobulin light chain lambda (V-J) gene rearrangements in the MCL. This report represents the first case of a blastoid variant of MCL occurring in composite with cHL.
1 St James's Hospital, Dublin, Ireland.
Ciara
C
Murray
1 St James's Hospital, Dublin, Ireland.
Fiona
F
Quinn
2 Bons Secours Hospital, Cork, Ireland.
Gyorgy
G
Illyes
1 St James's Hospital, Dublin, Ireland.
Jan
J
Walker
1 St James's Hospital, Dublin, Ireland.
Giussepa
G
Castriciano
2 Bons Secours Hospital, Cork, Ireland.
Paul
P
O'Sullivan
1 St James's Hospital, Dublin, Ireland.
Cliona
C
Grant
1 St James's Hospital, Dublin, Ireland.
Elisabeth
E
Vandenberghe
2 Bons Secours Hospital, Cork, Ireland.
Brian
B
Bird
1 St James's Hospital, Dublin, Ireland.
Richard
R
Flavin
D000368:Aged; D058617:Composite Lymphoma / Q000235:genetics / Q000473:pathology*; D006689:Hodgkin Disease / Q000235:genetics / Q000473:pathology*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008198:Lymph Nodes / Q000473:pathology; D020522:Lymphoma, Mantle-Cell / Q000235:genetics / Q000473:pathology*; D008297:Male; D060885:Multiplex Polymerase Chain Reaction
Hodgkin lymphoma; blastoid variant; composite lymphoma; mantle cell lymphoma