Generalized Posttransplant Kaposi Sarcoma without Mucocutaneous Manifestations in the First Liver Transplantation in an HIV-Positive Patient in Poland: A Case Report and Review of Literature.
BACKGROUND Kaposi sarcoma (KS) is the most frequent skin cancer in solid organ recipients, and also a typical malignancy in HIV-infected persons. CASE REPORT We describe here a rare case of primary nodal KS without mucocutaneous manifestations, diagnosed in a 20-year-old HIV/HBV co-infected patient 12 months after liver transplantation (LT), the first one performed in a HIV-positive patient in Poland. The course of the disease was very aggressive; the patient died four weeks after general lymphadenopathy appearance. In the autopsy, KS infiltration was found in numerous lymph nodes and in the lung' apexes without skin or other organs' involvement. CONCLUSIONS In conclusion, posttransplant KS may present as general lymphadenopathy without mucocutaneous manifestations, thus mimicking posttransplant lymphoproliferative disorder, which is often the first clinical suspicion. Lymph node histopathological examination is necessary to make the right diagnosis.
Department of Pathology, Medical University of Warsaw, Warsaw, Poland.
Bogna
B
Ziarkiewicz-Wróblewska
Department of Hepatology and Acquired Immunodeficiencies, Medical University of Warsaw, Warsaw, Poland.
Magdalena M
MM
Suchacz
Department of General, Transplant and Liver Surgery, Medical University of Warsaw, Warsaw, Poland.
Krzysztof
K
Zieniewicz
Department of Immunology, Transplantology and Internal Diseases, Medical University of Warsaw, Warsaw, Poland.
Michał
M
Ciszek
Department of General, Transplant and Liver Surgery, Medical University of Warsaw, Warsaw, Poland.
Urszula
U
Ołdakowska-Jedynak
Department of General, Transplant and Liver Surgery, Medical University of Warsaw, Warsaw, Poland.
Krzysztof
K
Dudek
Department of General, Transplant and Liver Surgery, Medical University of Warsaw, Warsaw, Poland.
Tadeusz
T
Wróblewski
Department of Pathology, Medical University of Warsaw, Warsaw, Poland.
Michał
M
Mazurkiewicz
Department of Pathology, Medical University of Warsaw, Warsaw, Poland.
Barbara
B
Górnicka
Department of Immunology, Transplantology and Internal Diseases, Medical University of Warsaw, Warsaw, Poland.
Leszek
L
Pączek
Department of General, Transplant and Liver Surgery, Medical University of Warsaw, Warsaw, Poland.
Marek
M
Krawczyk
Department of Hepatology and Acquired Immunodeficiencies, Medical University of Warsaw, Warsaw, Poland.
Alicja
A
Wiercińska-Drapało
D003937:Diagnosis, Differential; D017809:Fatal Outcome; D006679:HIV Seropositivity / Q000150:complications*; D006509:Hepatitis B / Q000150:complications / Q000601:surgery*; D006801:Humans; D017093:Liver Failure / Q000150:complications / Q000601:surgery*; D016031:Liver Transplantation / Q000009:adverse effects*; D008232:Lymphoproliferative Disorders / Q000175:diagnosis* / Q000209:etiology; D008297:Male; D011044:Poland; D011183:Postoperative Complications; D012514:Sarcoma, Kaposi / Q000175:diagnosis*; D055815:Young Adult