Relation between brain temperature and white matter damage in subacute carbon monoxide poisoning.
In the previous studies, carbon monoxide (CO) poisoning showed an imbalance between cerebral perfusion and metabolism in the acute phase and the brain temperature (BT) in these patients remained abnormally high from the acute to the subacute phase. As observed in chronic ischemic patients, BT can continuously remain high depending on impairments of cerebral blood flow and metabolism; this is because heat removal and production system in the brain may mainly be maintained by the balance of these two factors; thus, cerebral white matter damage (WMD) affecting normal metabolism may affect the BT in patients with CO poisoning. Here, we investigated whether the BT correlates with the degree of WMD in patients with subacute CO-poisoning. In 16 patients with subacute CO-poisoning, the BT and degree of WMD were quantitatively measured by using magnetic resonance spectroscopy and the fractional anisotropy (FA) value from diffusion tensor imaging dataset. Consequently, the BT significantly correlated with the degree of WMD. In particular, BT observed in patients with delayed neuropsychiatric sequelae, a crucial symptom with sudden-onset in the chronic phase after CO exposure, might indicate cerebral hypo-metabolism and abnormal hemodynamics like "matched perfusion," in which the reduced perfusion matches the reduced metabolism.
Department of Neurosurgery, Iwate Medical University, 19-1 Uchimaru, Morioka, Iwate 020-8505, Japan.
Shunrou
S
Fujiwara
Laboratory of Biofunctional Imaging, WPI Immunology Frontier Research Center, Osaka University, 3-1 Yamadaoka, Suita, Osaka 565-0871, Japan.
Yoshichika
Y
Yoshioka
MR Applications and Workflow Asia Pacific, GE Healthcare Japan, 4-7-127 Asahigaoka, Hino, Tokyo 191-8503, Japan.
Tsuyoshi
T
Matsuda
Department of Neurosurgery, Iwate Medical University, 19-1 Uchimaru, Morioka, Iwate 020-8505, Japan.
Hideaki
H
Nishimoto
Department of Neurosurgery, Iwate Medical University, 19-1 Uchimaru, Morioka, Iwate 020-8505, Japan.
Akira
A
Ogawa
Department of Neurosurgery, Iwate Medical University, 19-1 Uchimaru, Morioka, Iwate 020-8505, Japan.
Kuniaki
K
Ogasawara
Department of Neurosurgery, Iwate Medical University, 19-1 Uchimaru, Morioka, Iwate 020-8505, Japan.|Department of Hyperbaric Medicine, Iwate Medical University, 19-1 Uchimaru, Morioka, Iwate 020-8505, Japan.
Takaaki
T
Beppu
D000328:Adult; D000368:Aged; D016880:Anisotropy; D001831:Body Temperature / Q000187:drug effects* / Q000502:physiology*; D002248:Carbon Monoxide / Q000633:toxicity*; D002249:Carbon Monoxide Poisoning / Q000503:physiopathology*; D002560:Cerebrovascular Circulation / Q000187:drug effects; D054022:Cerebrum / Q000187:drug effects / Q000503:physiopathology; D056324:Diffusion Tensor Imaging / Q000379:methods; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D013696:Temperature; D066127:White Matter / Q000187:drug effects* / Q000503:physiopathology*; D055815:Young Adult
D002248:Carbon Monoxide