Prognosis for recipients with hepatocellular carcinoma of salvage liver transplantation versus those of primary liver transplantation: a retrospective single-center study.
OBJECTIVE
The prognosis for recipients with hepatocellular carcinoma (HCC) of salvage liver transplantation (SLT) versus those of primary liver transplantation (PLT) remains controversial. The objective of this study was to evaluate the clinical features and survival rate of SLT recipients.


METHODS
Three hundred seventy-one patients with HCC transplanted at Shanghai General Hospital, China, between October 2001 and October 2011 were separated into PLT (n = 295) and SLT (n = 76) groups. Patient characteristics and survival curves were studied by univariate and multivariate analysis. A Milan criteria-stratified survival analysis was conducted.


RESULTS
The proportions of reoperation (11.8 vs. 5.4 %,P= 0.047) and early postoperative mortality (11.8 vs. 4.7 %,P= 0.032) were higher in the SLT group than in the PLT group. Recurrence free survival (RFS) rate and overall survival (OS) rate had no statistically significant differences after stratification using Milan criteria between the PLT group and SLT group. Alphafetoprotein >400 ng/mL (P= 0.011), microscopic vascular invasion (MVI) (P< 0.001), tumor node metastasis (TNM) staging (P= 0.006), and out of Milan criteria (P< 0.001) were independent risk factors for RFS, while MVI (P< 0.001), TNM staging (P= 0.009), and out of Milan criteria (P= 0.003) were factors for OS. In the multivariate logistic regression analysis, HCC recurrence was associated with MVI (OR = 4.196 [2.538-6.936],P< 0.001), and out of Milan criteria (OR = 2.704 [1.643-4.451],P< 0.001).


CONCLUSIONS
Our retrospective, single-center study demonstrated that SLT increases surgical difficulty; however, it has good post-transplantation OS and is a feasible alternative after HCC recurrence within Milan criteria.
Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 100 Haining Road, Shanghai, 200080 China.
Pusen
P
Wang
Department of Nursing, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 100 Haining Road, Shanghai, 200080 China.
Ying
Y
Pu
Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 100 Haining Road, Shanghai, 200080 China.
Hao
H
Li
Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 100 Haining Road, Shanghai, 200080 China.
Baojie
B
Shi
Department of Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210029 Jiangsu province China.
Shengnai
S
Zheng
Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 100 Haining Road, Shanghai, 200080 China.
Lin
L
Zhong
Hepatocellular carcinoma; Primary liver transplantation; Prognosis; Salvage liver transplantation