Effects of alcohol on c-Myc protein in the brain.
Alcoholism is a disorder categorized by significant impairment that is directly related to persistent and extreme use of alcohol. The effects of alcoholism on c-Myc protein expression in the brain have been scarcely studied. This is the first study to investigate the role different characteristics of alcoholism have on c-Myc protein in the brain. We analyzed c-Myc protein in the hypothalamus and amygdala from five different animal models of alcohol abuse. c-Myc protein was increased following acute ethanol exposure in a mouse knockout model and following chronic ethanol consumption in vervet monkeys. We also observed increases in c-Myc protein exposure in animals that are genetically predisposed to alcohol and methamphetamine abuse. Lastly, c-Myc protein was increased in animals that were acutely exposed to methamphetamine when compared to control treated animals. These results suggest that in substance abuse c-Myc plays an important role in the brain's response.
Department of Behavioral Neuroscience, ONPRC, Oregon Health and Science University, Portland, OR 97239, United States.
Tunde
T
Akinyeke
Department of Behavioral Neuroscience, ONPRC, Oregon Health and Science University, Portland, OR 97239, United States.
Sydney J
SJ
Weber
Department of Physiology and Pharmacology, Wake Forest School of Medicine, Winston Salem, NC 27106, United States.
April T
AT
Davenport
School of Engineering and Department of Computer Science, Baylor University Waco, TX 76978, United States.
Erich J
EJ
Baker
Department of Physiology and Pharmacology, Wake Forest School of Medicine, Winston Salem, NC 27106, United States.
James B
JB
Daunais
Department of Behavioral Neuroscience, ONPRC, Oregon Health and Science University, Portland, OR 97239, United States; Departments of Neurology and Radiation Medicine, Division of Neuroscience, ONPRC, Oregon Health and Science University, Portland, OR 97239, United States. Electronic address: raberj@ohsu.edu.
Jacob
J
Raber
D000437:Alcoholism / Q000235:genetics / Q000473:pathology*; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002492:Central Nervous System Depressants / Q000494:pharmacology*; D000697:Central Nervous System Stimulants / Q000494:pharmacology; D002522:Chlorocebus aethiops; D050759:Cyclin-Dependent Kinase Inhibitor p21 / Q000378:metabolism; D004195:Disease Models, Animal; D000431:Ethanol / Q000494:pharmacology*; D005786:Gene Expression Regulation / Q000187:drug effects*; D020022:Genetic Predisposition to Disease; D008694:Methamphetamine / Q000494:pharmacology; D051379:Mice; D018345:Mice, Knockout; D016271:Proto-Oncogene Proteins c-myc / Q000378:metabolism*; D018094:Receptors, Metabotropic Glutamate / Q000172:deficiency / Q000235:genetics
D002492:Central Nervous System Depressants; D000697:Central Nervous System Stimulants; D050759:Cyclin-Dependent Kinase Inhibitor p21; D016271:Proto-Oncogene Proteins c-myc; D018094:Receptors, Metabotropic Glutamate; C111435:metabotropic glutamate receptor 8; D000431:Ethanol; D008694:Methamphetamine
Alcoholism; Phosphorylation; Preference; Withdrawal; c-Myc