Psoriasis risk SNPs and their association with HIV-1 control.
Human evolution has resulted in selection for genetic polymorphisms beneficial in the defense against pathogens. However, such polymorphisms may have the potential to heighten the risk of autoimmune disease. Here, we investigated whether psoriasis-associated single nucleotide polymorphisms influence host control of HIV-1 infection. We studied psoriasis and viral immune response variants in three HIV-positive cohorts: (1) HIV-1 controllers and non-controllers in the Study of the Consequences of the Protease Inhibitor Era (SCOPE) cohort (n=366), (2) Individuals with primary HIV infection in the Options cohort (n=675), and (3) HIV-positive injection drug users from the Urban Health Study (UHS) (n=987). We found a strong association of two psoriasis MHC variants, rs9264942 and rs3021366, with both HIV-1 controller status and viral load, and identified another Class III MHC variant rs9368699 to be strongly associated with viral load. A number of genetic variants outside the MHC (SOX5, TLR9, SDC4, PROX1, IL12B, TLR4, MBL-2, TYK2, IFIH1) demonstrated nominal significance. Overall, our data suggest that several psoriasis variants within the MHC have a robust impact on HIV-1 control, while variants outside the MHC require further investigation.
Department of Dermatology, University of California San Francisco, San Francisco, CA, USA.
Joanne
J
Nititham
Department of Dermatology, University of California San Francisco, San Francisco, CA, USA.
Rashmi
R
Gupta
Department of Dermatology, University of California San Francisco, San Francisco, CA, USA.
Xue
X
Zeng
Division of HIV/AIDS, Department of Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, CA, USA.
Wendy
W
Hartogensis
Department of Microbiology, Immunology and Tropical Medicine, The George Washington University, Washington, DC, USA.
Douglas F
DF
Nixon
Division of HIV/AIDS, Department of Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, CA, USA.
Steven G
SG
Deeks
Division of HIV/AIDS, Department of Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, CA, USA.
Frederick M
FM
Hecht
Department of Dermatology, University of California San Francisco, San Francisco, CA, USA. Electronic address: wilson.liao@ucsf.edu.
Wilson
W
Liao
D000328:Adult; D058070:Asymptomatic Diseases; D015331:Cohort Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D015658:HIV Infections / Q000235:genetics*; D015497:HIV-1 / Q000502:physiology*; D006680:HLA Antigens / Q000235:genetics*; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011565:Psoriasis / Q000235:genetics*; D012306:Risk; D014505:Urban Population; D019562:Viral Load / Q000235:genetics
D006680:HLA Antigens
Genetics; HIV; Immunogenetics; MHC; Primary infection; Psoriasis; Viral control; Viral load