Changes in exercise capacity, muscle strength, and health-related quality of life in esophageal cancer patients undergoing esophagectomy.
BACKGROUND
Surgery for cancer of the thoracic esophagus is a challenging procedure associated with high morbidity and mortality. Perioperative rehabilitation has been introduced to promote early mobilization of the patients and to prevent postoperative pulmonary complications. The purpose of the present study was to characterize the preoperative functional exercise capacity, muscle strength, anxiety, depression, and health-related quality of life (QOL) in patients with esophageal cancer, and to evaluate the impact of radical esophagectomy on these parameters.


METHODS
We performed a retrospective review of 34 consecutive patients with newly diagnosed resectable esophageal cancer who underwent esophagectomy followed by postoperative rehabilitation from January to December 2014. Patients were tested for 6-min walk distance (6MWD), knee-extensor muscle strength, hand grip strength, the Hospital Anxiety and Depression Scale (HADS), and the chronic obstructive pulmonary disease (COPD) assessment test (CAT) before and two weeks after the surgery. Before surgery, the pulmonary function test, and components of the MOS 36-item Short-Form Health Survey (SF-36) Questionnaire for general health were assessed.


RESULTS
The mean age was 67.3 ± 8.1 years. The patients were predominantly male (76.4 %), had high rates of smoking history (91.2 %), and squamous cell carcinoma (97.1 %). The predicted value for forced expiratory volume in 1 s was 94.0 ± 15.9 %, and 12 patients (35.3 %) had COPD. The clinical stage was 0-I in 12 patients, II in 4 patients, III in 16 patients, and IV in 2 patients. Thirty-one patients (91.2 %) underwent open surgery. At the baseline, components of the SF-36 scores significantly correlated with CAT and HADS scores, and the physical status was significantly poorer in patients with COPD than those without. Comparisons between the preoperative and postoperative values revealed significant decreases in 6MWD, hand grip strength, isometric knee extensor muscle strength, and a significant increase in CAT scores but not in HADS scores after surgery. In multiple regression analysis, decreases in 6MWD after the surgery significantly correlated with the preoperative physical component summary of SF-36.


CONCLUSIONS
Our results indicate that surgery remained detrimental to health outcomes at two weeks. Further research should investigate whether prehabilitation would improve the postoperative outcomes, QOL, and physical fitness.
Department of Rehabilitation, Nagoya University School of Medicine, Nagoya, 466-8550 Japan.
Takayuki
T
Inoue
Department of Rehabilitation, Nagoya University School of Medicine, Nagoya, 466-8550 Japan.|Department of Respiratory Medicine, Nagoya University School of Medicine, Nagoya, 466-8550 Japan.
Satoru
S
Ito
Center for Advanced Medicine and Clinical Research, Nagoya University School of Medicine, Nagoya, 466-8550 Japan.
Masahiko
M
Ando
Department of Rehabilitation, Nagoya University School of Medicine, Nagoya, 466-8550 Japan.
Motoki
M
Nagaya
Department of Respiratory Medicine, Nagoya University School of Medicine, Nagoya, 466-8550 Japan.
Hiromichi
H
Aso
Department of Rehabilitation, Nagoya University School of Medicine, Nagoya, 466-8550 Japan.
Yota
Y
Mizuno
Department of Rehabilitation, Nagoya University School of Medicine, Nagoya, 466-8550 Japan.
Keiko
K
Hattori
Department of Rehabilitation, Nagoya University School of Medicine, Nagoya, 466-8550 Japan.
Hiroki
H
Nakajima
Department of Rehabilitation, Nagoya University School of Medicine, Nagoya, 466-8550 Japan.
Yoshihiro
Y
Nishida
Gastroenterological Surgery II, Nagoya University School of Medicine, Nagoya, 466-8550 Japan.
Yukiko
Y
Niwa
Gastroenterological Surgery II, Nagoya University School of Medicine, Nagoya, 466-8550 Japan.
Yasuhiro
Y
Kodera
Gastroenterological Surgery II, Nagoya University School of Medicine, Nagoya, 466-8550 Japan.
Masahiko
M
Koike
Department of Respiratory Medicine, Nagoya University School of Medicine, Nagoya, 466-8550 Japan.
Yoshinori
Y
Hasegawa
COPD assessment test; Esophagectomy; Health-related quality of life; Pulmonary rehabilitation; Six-minute walk test