Clinical Features of Pituitary Stalk Interruption Syndrome in 114 Cases.
Objective To analyze the clinical characteristics of pituitary stalk interruption syndrome(PSIS). Methods The clinical data including clinical manifestations,laboratory tests,and imaging findings of 114 PSIS patients in our hospital were retrospectively analyzed. Results Of these 114 PSIS patients,102 cases (89.4%) were male. The average age was 21.1?6.1 years. A history of breech delivery was documented in 91 cases (91.9%). Short stature was found in 89 cases (71.8%) and bone age delayed (6.1?5.1) years. Secondary sex characteristics were poor or undeveloped in most patients. The prevalence of deficiencies in growth hormone,gonadotropins,corticotropin,and thyrotropin were 100.0%,94.0%,84.2%,and 74.6%,respectively. Hyperprolactinemia was found in 28.1% of patients. Three or more pituitary hormone abnormalities were found in 105 cases(92.1%). Compared with the 5 cases with history of cephalic delivery,no difference were found in the aspects of height(t=0.297,P=0.634),penile length(t=1.205,P=0.882),testicular volume (U=99.000,P=0.348),growth hormone peak (U=89.000,P=0.186),adrenocorticotropic hormone peak(U=131.000,P=0.967),luteinizing hormone peak(U=98.500,P=0.582),thyroid-stimulating hormone (U=82.000,P=0.162),and the height of anterior pituitary (t=1.676,P=0.107) in the 53 cases with history of breech delivery. Conclusions The clinical manifestations,symptoms,hormone deficiencies were severe in our series. The condition severities were not remarkably different in patients with different delivery ways.
1Department of Endocrinology,Chinese PLA General Hospital,Beijing 100853,China; 2Department of Endocrinology,the 264th Hospital of PLA,Taiyuan 030001,China.
Bai-Yu
BY
Han
1Department of Endocrinology,Chinese PLA General Hospital,Beijing 100853,China; 3Department of Endocrinology,PLA Army General Hospital,Beijing 100700,China.
Qian
Q
Zhang
1Department of Endocrinology,Chinese PLA General Hospital,Beijing 100853,China.
Le-Le
LL
Li
1Department of Endocrinology,Chinese PLA General Hospital,Beijing 100853,China.
Qing-Hua
QH
Guo
1Department of Endocrinology,Chinese PLA General Hospital,Beijing 100853,China.
Cheng-Zhi
CZ
Wang
1Department of Endocrinology,Chinese PLA General Hospital,Beijing 100853,China.
Li
L
Cang
1Department of Endocrinology,Chinese PLA General Hospital,Beijing 100853,China.
Nan
N
Jin
1Department of Endocrinology,Chinese PLA General Hospital,Beijing 100853,China.
Fang
F
Chen
1Department of Endocrinology,Chinese PLA General Hospital,Beijing 100853,China.
Ling
L
Zhao
1Department of Endocrinology,Chinese PLA General Hospital,Beijing 100853,China.
Jia
J
Cui
1Department of Endocrinology,Chinese PLA General Hospital,Beijing 100853,China.
Xiu-Lian
XL
Gu
1Department of Endocrinology,Chinese PLA General Hospital,Beijing 100853,China.
Fang-Ling
FL
Ma
1Department of Endocrinology,Chinese PLA General Hospital,Beijing 100853,China.
Sai-Chun
SC
Zhang
1Department of Endocrinology,Chinese PLA General Hospital,Beijing 100853,China.
Yi-Ming
YM
Mu
1Department of Endocrinology,Chinese PLA General Hospital,Beijing 100853,China.
Jing-Tao
JT
Dou
D000293:Adolescent; D000328:Adult; D004392:Dwarfism / Q000209:etiology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D010900:Pituitary Diseases / Q000150:complications / Q000503:physiopathology*; D010902:Pituitary Gland / Q000473:pathology*; D015995:Prevalence; D012189:Retrospective Studies; D055815:Young Adult