Encapsulated papillary carcinoma (EPC) of breast: A clinical, pathological and immunohistochemical analysis of eight cases.
Encapsulated papillary carcinoma (EPC) is a rare low grade carcinoma of the breast with excellent prognosis. This case series focuses on its histopathological and clinical characteristics in our material. Cases of papillary lesions of breast from 1st January 2012 to 30th December 2014 were retrieved from the hospital database. A total of 8 cases were categorized as EPC. Mean age of patients was 66 years. Breast lump with tumour size ranged from 1.5 to 5.0cm, and was the presentation in 75% of cases. Histopathology showed a well circumscribed lesion within a dilated duct comprising of fibro vascular cores lined by neoplastic cells, surrounded by thick fibrous capsule. Immunohistochemistry, for antibody panel p63, ASMA and CK 5/6 were negative for myoepithelial cells. Invasive carcinoma was seen in 3 (37.5%) with associated DCIS in 4 (50%) cases. Meticulous gross, attention to morphology and correct interpretation of immunohistochemistry are imperative for accurate diagnosis.
Shifa International Hospital, Islamabad.
Naima
N
Tariq
Shifa International Hospital, Islamabad.
Nadira
N
Mamoon
Shifa International Hospital, Islamabad.
Mariam
M
Usman
Shifa International Hospital, Islamabad.
Zafar
Z
Ali
Shifa International Hospital, Islamabad.
Imran
I
Nazir
D000368:Aged; D014408:Biomarkers, Tumor; D001943:Breast Neoplasms / Q000473:pathology*; D002278:Carcinoma in Situ; D002285:Carcinoma, Intraductal, Noninfiltrating; D002291:Carcinoma, Papillary / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry
D014408:Biomarkers, Tumor
Encapsulated papillary carcinoma, Myoepithelial cells, Prognosis, Immunohistochemistry.
