In vitrothrombolytic activity ofDhamasa(Fagonia arabicaLinn.),Kushta(Saussurea lappaDecne.), andGuduchi(Tinospora cordifoliaThunb.).
BACKGROUND
Thrombotic disorders are among the major fatal conditions affecting the society. Treatment modalities used for such disorders are either surgical interventions or use of drugs such as urokinase, streptokinase (SK), or tissue plasminogen activators to dissolve the blood clots. These modalities have their own limitations and side effects apart from being expensive. There is a need for safer and cost effective antithrombolytic agents.


OBJECTIVE
To evaluatein vitrothrombolytic property ofDhamasa(Fagonia arabicaLinn.),Kushta(Saussurea lappaDecne.), andGuduchi(Tinospora cordifoliaThunb.) plant extract.


METHODS
Venous blood drawn from 20 healthy volunteers was allowed to form clots which was weighed and treated with the extract of test plant materials to disrupt the clots. Weight of clot after and before treatment provided a percentage of clot lysis. SK was used as a positive and water as a negative control.


METHODS
The significance between % clot lysis of five groups by means of weight difference was tested by the one-way ANOVA.


RESULTS
Clot lysis observed were 68.06%, 14.85%, 25.01%, 92.54%, and 3.00% forDhamasa,Kushta,Guduchi, SK, and distilled water, respectively.


CONCLUSIONS
Herbal extracts possess thrombolytic properties and lyse blood clotsin vitro.
Lecturer, Department of Roga Nidana and Vikriti Vijnana, Aligarh Unani and Ayurvedic Medical College, Aligarh, UP, India.
Shweta
S
Chaudhary
Department of Roga Nidana and Vikriti Vigyan, National Institute of Ayurveda, Jaipur, Rajasthan, India.
Pawan Kumar
PK
Godatwar
Department of Roga Nidana and Vikriti Vigyan, National Institute of Ayurveda, Jaipur, Rajasthan, India.
Reetu
R
Sharma
Dhamasa; Fagonia arabica; Guduchi; Kushta; Saussurea lappa; Tinospora cordifolia; streptokinase; thrombolytic activity