Use of serum and urinary soluble sFlt-1 and PLGF in the diagnosis of preeclampsia.
OBJECTIVE
Preeclampsia (PE) is a disorder of pregnancy marked by hypertension and proteinuria with no known treatment aside from pregnancy termination. The pathogenesis of PE is poorly understood, but is thought to originate in the placenta. We assessed the value of measuring serum and urinary soluble deformylase-like tyrosine kinase receptor 1 (sFlt-1), a known target of placental factors, and placental growth factor (PLGF), a key placental signaling molecule, in the diagnosis of PE.


METHODS
Eighty patients with PE were classified as either exhibiting mild (44 cases) or severe (36 cases) symptoms of PE. Forty normal pregnant women were selected as controls. Serum and urinary PLGF and sFlt-1 levels, along with the ratio of sFlt-1 to PLGF, were compared across groups.


RESULTS
Serum and urinary sFlt-1 and sFlt-1/PLGF ratios in severe PE patients were significantly higher than those in the mild PE group, and measurements from mild PE patients were significantly higher than controls (all P values <0.01). The serum and urinary PLGF levels in severe PE patients were significantly lower than mild PE patients, and mild PE patients had significantly lower PLGF levels than controls (all P values <0.01). As expected, serum sFlt-1 and PLGF levels and ratios were highly correlated with urinary sFlt-1 and PLGF levels and ratios.


CONCLUSIONS
The severity of PE was closely correlated with these measurements, suggesting that they may be useful tools in the diagnosis and evaluation of PE.
a Obstetrics Department , The Second People's Hospital of Liaocheng City , Liaocheng, Shandong Province, P. R . China.
Ping
P
Tang
b Department of Clinical Laboratory , The Second People's Hospital of Liaocheng City , Liaocheng, Shandong Province, P. R . China.
Jing
J
Xu
b Department of Clinical Laboratory , The Second People's Hospital of Liaocheng City , Liaocheng, Shandong Province, P. R . China.
Bao-Jun
BJ
Xie
a Obstetrics Department , The Second People's Hospital of Liaocheng City , Liaocheng, Shandong Province, P. R . China.
Qi-Mei
QM
Wang
D000328:Adult; D015415:Biomarkers / Q000097:blood / Q000652:urine; D005260:Female; D006801:Humans; D000072483:Placenta Growth Factor / Q000097:blood / Q000378:metabolism* / Q000652:urine; D011225:Pre-Eclampsia / Q000097:blood / Q000175:diagnosis* / Q000652:urine; D011247:Pregnancy; D011262:Pregnancy Trimester, Second / Q000097:blood / Q000652:urine; D012720:Severity of Illness Index; D040281:Vascular Endothelial Growth Factor Receptor-1 / Q000097:blood / Q000378:metabolism* / Q000652:urine; D055815:Young Adult
D015415:Biomarkers; D000072483:Placenta Growth Factor; D040281:Vascular Endothelial Growth Factor Receptor-1
Diagnosis; placenta growth factor; preeclampsia; soluble FMS-like tyrosine kinase receptor 1