Serum serotonin concentration associated with bone mineral density in Chinese postmenopausal women.
Recent studies have shown that circulating serotonin plays a potential role in bone metabolism. However, conflicting results have been reported for the relationship between serum serotonin concentrations and bone mineral density (BMD). We investigated whether the serum serotonin concentrations related to BMD in Chinese postmenopausal women. Serum serotonin and bone turnover concentrations of 117 premenopausal women and 262 asymptomatic postmenopausal women were analyzed by enzyme-linked immunosorbent assay. BMD at the lumbar spine and femoral neck was measured by dual energy X-ray absorptiometry. The relationship between serotonin and BMD was investigated. The postmenopausal women had lower mean serum serotonin concentrations compared to the premenopausal women. Serotonin concentrations were negatively associated with age, weight, BMI, fat mass, and β-CTX concentrations in postmenopausal women. No significant correlations were found between serotonin and these parameters in premenopausal women. In postmenopausal women, age- and BMI-adjusted serotonin concentrations were positively correlated with BMD of the lumbar spine and femoral neck. Multiple regression analyses showed serum serotonin and β-CTX were the predictors for lumbar spine BMD. Only serum serotonin was the determinant for femoral neck BMD. In conclusion, lower serum serotonin concentrations are linked to low lumbar spine and femoral neck BMD in postmenopausal women.
a Department of Orthopaedics Surgery , The First Affiliated Hospital of Guangzhou University of Chinese Medicine , Guangzhou , P. R. China.|b Key Laboratory of Orthopaedics & Traumatology , Guangzhou University of Chinese Medicine , Guangzhou , P. R. China.
Qiu-Shi
QS
Wei
a Department of Orthopaedics Surgery , The First Affiliated Hospital of Guangzhou University of Chinese Medicine , Guangzhou , P. R. China.
Zhen-Qiu
ZQ
Chen
c Department of Six Internal Medicine , General Hospital of Guangzhou Military Command of PLA , Guangzhou , P. R. China.
Xin
X
Tan
c Department of Six Internal Medicine , General Hospital of Guangzhou Military Command of PLA , Guangzhou , P. R. China.
Lu-Chen
LC
Kang
a Department of Orthopaedics Surgery , The First Affiliated Hospital of Guangzhou University of Chinese Medicine , Guangzhou , P. R. China.
Xiao-Bing
XB
Jiang
d Department of Rheumatology , The Second Affiliated Hospital of Guiyang University of Chinese Medicine , Guizhou , P. R. China.
Jiang
J
Liang
a Department of Orthopaedics Surgery , The First Affiliated Hospital of Guangzhou University of Chinese Medicine , Guangzhou , P. R. China.|b Key Laboratory of Orthopaedics & Traumatology , Guangzhou University of Chinese Medicine , Guangzhou , P. R. China.
Wei
W
He
c Department of Six Internal Medicine , General Hospital of Guangzhou Military Command of PLA , Guangzhou , P. R. China.
Wei-Min
WM
Deng
D015502:Absorptiometry, Photon; D000273:Adipose Tissue; D000328:Adult; D000368:Aged; D044466:Asian People; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D001835:Body Weight; D015519:Bone Density; D016723:Bone Remodeling; D024042:Collagen Type I / Q000097:blood*; D003430:Cross-Sectional Studies; D005260:Female; D005272:Femur Neck / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology; D050723:Fractures, Bone / Q000097:blood* / Q000000981:diagnostic imaging / Q000208:ethnology / Q000473:pathology; D006801:Humans; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology; D008875:Middle Aged; D010455:Peptides / Q000097:blood*; D017698:Postmenopause / Q000097:blood* / Q000208:ethnology; D017697:Premenopause / Q000097:blood / Q000208:ethnology; D012701:Serotonin / Q000097:blood*
D015415:Biomarkers; D024042:Collagen Type I; D010455:Peptides; C052929:collagen type I trimeric cross-linked peptide; D012701:Serotonin
Bone mineral density (BMD); bone metabolism; postmenopausal women; serotonin