Multiple functions of USP18.
Since the discovery of the ubiquitin system and the description of its important role in the degradation of proteins, many studies have shown the importance of ubiquitin-specific peptidases (USPs). One special member of this family is the USP18 protein (formerly UBP43). In the past two decades, several functions of USP18 have been discovered: this protein is not only an isopeptidase but also a potent inhibitor of interferon signaling. Therefore, USP18 functions as 'a' maestro of many biological pathways in various cell types. This review outlines multiple functions of USP18 in the regulation of various immunological processes, including pathogen control, cancer development, and autoimmune diseases.
Institute of Immunology, Medical Faculty, University of Duisburg-Essen, Hufelandstr. 55, Essen 45147, Germany.
Nadine
N
Honke
Institute of Immunology, Medical Faculty, University of Duisburg-Essen, Hufelandstr. 55, Essen 45147, Germany.|Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Namir
N
Shaabani
Moores UCSD Cancer Center, University of California San Diego, La Jolla, CA 92093, USA.
Dong-Er
DE
Zhang
Institute of Immunology, Medical Faculty, University of Duisburg-Essen, Hufelandstr. 55, Essen 45147, Germany.
Cornelia
C
Hardt
Institute of Immunology, Medical Faculty, University of Duisburg-Essen, Hufelandstr. 55, Essen 45147, Germany.
Karl S
KS
Lang
D000818:Animals; D000900:Anti-Bacterial Agents / Q000378:metabolism; D001327:Autoimmune Diseases / Q000378:metabolism; D063646:Carcinogenesis / Q000378:metabolism / Q000473:pathology; D010450:Endopeptidases / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D014777:Virus Diseases / Q000378:metabolism
D000900:Anti-Bacterial Agents; D010450:Endopeptidases