A Facile and Eco-friendly Route to Fabricate Poly(Lactic Acid) Scaffolds with Graded Pore Size.
Over the recent years, functionally graded scaffolds (FGS) gaineda crucial role for manufacturing of devices for tissue engineering. The importance of this new field of biomaterials research is due to the necessity to develop implants capable of mimicking the complex functionality of the various tissues, including a continuous change from one structure or composition to another. In this latter context, one topic of main interest concerns the design of appropriate scaffolds for bone-cartilage interface tissue. In this study, three-layered scaffolds with graded pore size were achieved by melt mixing poly(lactic acid) (PLA), sodium chloride (NaCl) and polyethylene glycol (PEG). Pore size distributions were controlled by NaCl granulometry and PEG solvation. Scaffolds were characterized from a morphological and mechanical point of view. A correlation between the preparation method, the pore architecture and compressive mechanical behavior was found. The interface adhesion strength was quantitatively evaluated by using a custom-designed interfacial strength test. Furthermore, in order to imitate the human physiology, mechanical tests were also performed in phosphate buffered saline (PBS) solution at 37 °C. The method herein presented provides a high control of porosity, pore size distribution and mechanical performance, thus offering the possibility to fabricate three-layered scaffolds with tailored properties by following a simple and eco-friendly route.
Department of civil, environmental, aerospace, and materials engineering (DICAM), RU INSTM, University of Palermo; roberto.scaffaro@unipa.it.
Roberto
R
Scaffaro
Department of civil, environmental, aerospace, and materials engineering (DICAM), RU INSTM, University of Palermo.
Francesco
F
Lopresti
Department of civil, environmental, aerospace, and materials engineering (DICAM), RU INSTM, University of Palermo.
Luigi
L
Botta
Department of civil, environmental, aerospace, and materials engineering (DICAM), RU INSTM, University of Palermo.
Andrea
A
Maio
Department of civil, environmental, aerospace, and materials engineering (DICAM), RU INSTM, University of Palermo.
Fiorenza
F
Sutera
Department of civil, environmental, aerospace, and materials engineering (DICAM), RU INSTM, University of Palermo.
Maria Chiara
MC
Mistretta
Department of civil, environmental, aerospace, and materials engineering (DICAM), RU INSTM, University of Palermo.
Francesco Paolo
FP
La Mantia
D001672:Biocompatible Materials; D006801:Humans; D019344:Lactic Acid; D011092:Polyethylene Glycols; D011108:Polymers; D016062:Porosity; D023822:Tissue Engineering; D054457:Tissue Scaffolds
D001672:Biocompatible Materials; D011108:Polymers; D019344:Lactic Acid; D011092:Polyethylene Glycols