Negative correlation between CSF zinc level and anxiety in male Chinese subjects.
Zinc is crucial for brain development and psychiatric regulation. In the present study, we investigated the relationship between cerebrospinal fluid (CSF) zinc level and anxiety in a group of male Chinese subjects. Results demonstrated that zinc levels had no considerable interindividual variations, ranging from 8.37 to 16.83µm. Correlation analyses revealed that CSF Zinc levels were positively correlated with education years (r=0.225, p=0.024) and negatively correlated with SAS scores (r=-0.287, p=0.004), but not associated with age or BMI. In conclusion, this present study suggests that CSF zinc level is associated with anxiety.
Department of Molecular Biology and Biochemistry, Xinxiang Medical University, Xinxiang 453003, China.
Na
N
Song
Inner Mongolia Region Mental Health Center, Huhhot 010110, China; Psychosomatic Medicine Research Division, Inner Mongolia Medical University, Huhhot 010110, China.
Dongsheng
D
Yu
Psychosomatic Medicine Research Division, Inner Mongolia Medical University, Huhhot 010110, China.
Yimin
Y
Kang
The PLA Psychiatry Center, The 102nd Hospitial of PLA, Changzhou 213003, China.
Zhiyong
Z
Cao
Beijing Jishuitan Hospital, Beijing 100035, China.
Xiaoyu
X
Yang
Psychology and Sleep Department of Guang׳an Men Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China.
Jian
J
Wang
College of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China. Electronic address: benjaminlyl@wmu.edu.cn.
Yanlong
Y
Liu
Beijing Hui-Long-Guan Hospital, Peking University, Beijing 100096, China. Electronic address: FanWang@bjmu.edu.cn.
Fan
F
Wang
D000328:Adult; D001007:Anxiety / Q000134:cerebrospinal fluid* / Q000175:diagnosis / Q000523:psychology*; D044466:Asian People / Q000523:psychology*; D015415:Biomarkers / Q000134:cerebrospinal fluid; D004522:Educational Status; D006801:Humans; D008297:Male; D055815:Young Adult; D015032:Zinc / Q000134:cerebrospinal fluid*
D015415:Biomarkers; D015032:Zinc
CSF; SAS; Zinc