Preclinical Swine Models for Monitoring of Hepatocyte Transplantation by MRI.
Hepatocyte transplantation is a promising approach for treatment of certain liver disorders, especially for metabolic liver disease in the juvenile. The lack of a clinically approved noninvasive imaging technique is a major limitation to the further development of hepatocyte transplantation. Cell tracking by Magnetic Resonance Imaging (MRI) is a promising approach for noninvasive monitoring of the fate of transplanted cells. Studies in large animal models are necessary to transfer this promising technique into the clinic.
Department of Surgery, Campus Charité Mitte, Campus Virchow-Klinikum, Experimental Surgery and Regenerative Medicine, Charité - Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany. Nathanael.raschzok@charite.de.
Nathanael
N
Raschzok
Department of Radiology, Universitätsklinikum Jena, Jena, Germany.
Ulf
U
Teichgräber
Department of Surgery, Campus Charité Mitte, Campus Virchow-Klinikum, Experimental Surgery and Regenerative Medicine, Charité - Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.
Johann
J
Pratschke
Department of Surgery, Campus Charité Mitte, Campus Virchow-Klinikum, Experimental Surgery and Regenerative Medicine, Charité - Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.
Igor M
IM
Sauer
D000818:Animals; D058948:Cell Tracking / Q000379:methods*; D017690:Cell Transplantation / Q000379:methods*; D003287:Contrast Media / Q000008:administration & dosage; D005260:Female; D005290:Ferric Compounds / Q000008:administration & dosage; D019786:Gadolinium DTPA / Q000008:administration & dosage; D022781:Hepatocytes / Q000637:transplantation*; D007150:Immunohistochemistry; D008099:Liver / Q000000981:diagnostic imaging / Q000601:surgery; D008107:Liver Diseases / Q000601:surgery; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D023421:Models, Animal; D034421:Sus scrofa; D013552:Swine
D003287:Contrast Media; D005290:Ferric Compounds; C000499:ferric oxide; D019786:Gadolinium DTPA
Cell tracking; Cell transplantation; Fast-dynamic MRI; Hepatocyte transplantation; Liver cell transplantation; Real-time MRI