Advances in the Relationship between Adipokines and β-cell Failure in Type 2 Diabetes Mellitus.
β-cell failure coupled with insulin resistance plays a key role in the development of type 2 diabetes mellitus (T2DM). Changed adipokines in circulating level form a remarkable link between obesity and both β-cell failure and insulin resistance. Some adipokines have beneficial effects,whereas others have detrimental properties. The overall contribution of adipokines to β-cell failure mainly depends on the interactions among adipokines. This article reviews the role of individual adipokines such as leptin,adiponectin,and resistin in the function,proliferation,death,and failure of β-cells. Future studies focusing on the combined effects of adipokines on β-cells failure may provide new insights in the treatment of T2DM.
Department of Traditional Chinese Medicine,PUMC Hospital, CAMS and PUMC,Beijing 100730,China.
Qing
Q
Sun
Department of Traditional Chinese Medicine,PUMC Hospital, CAMS and PUMC,Beijing 100730,China.
Xiao-Chun
XC
Liang
D054392:Adipokines / Q000378:metabolism*; D052242:Adiponectin / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D006801:Humans; D007333:Insulin Resistance; D050417:Insulin-Secreting Cells / Q000473:pathology*; D020738:Leptin / Q000378:metabolism; D009765:Obesity; D052243:Resistin / Q000378:metabolism
C499918:ADIPOQ protein, human; D054392:Adipokines; D052242:Adiponectin; D020738:Leptin; C499624:RETN protein, human; D052243:Resistin