LSD1 Makes Fat Colorful.
The histone lysine-specific demethylase 1 (LSD1) is a new and important player in the regulation of brown fat identity and function. In a recent Cell Reports article, Duteil et al. show that LSD1 exerts its effects via regulation of specific histone marks as well as through association with co-repressor complexes.
Institute of Food, Nutrition, and Health, Eidgenössische Technische Hochschule (ETH) Zürich, Schorenstrasse 16, 8603 Schwerzenbach, Switzerland.
Leon G
LG
Straub
Institute of Food, Nutrition, and Health, Eidgenössische Technische Hochschule (ETH) Zürich, Schorenstrasse 16, 8603 Schwerzenbach, Switzerland. Electronic address: christian-wolfrum@ethz.ch.
Christian
C
Wolfrum
D000818:Animals; D056466:Histone Demethylases / Q000235:genetics / Q000378:metabolism*; D006657:Histones / Q000378:metabolism; D006801:Humans; D050356:Lipid Metabolism / Q000235:genetics / Q000502:physiology; D014158:Transcription, Genetic / Q000235:genetics
D006657:Histones; D056466:Histone Demethylases; C495195:KDM1A protein, human