Hyperbaric oxygen preconditioning: a reliable option for neuroprotection.
Brain injury is the leading cause of death and disability worldwide and clinically there is no effective therapy for neuroprotection. Hyperbaric oxygen preconditioning (HBO-PC) has been experimentally demonstrated to be neuroprotective in several models and has shown efficiency in patients undergoing on-pump coronary artery bypass graft (CABG) surgery. Compared with other preconditioning stimuli, HBO is benign and has clinically translational potential. In this review, we will summarize the results in experimental brain injury and clinical studies, elaborate the mechanisms of HBO-PC, and discuss regimes and opinions for future interventions in acute brain injury.
Departments of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, CA, USA.
Qin
Q
Hu
Departments of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, CA, USA.
Anatol
A
Manaenko
Departments of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, CA, USA.
Nathanael
N
Matei
Departments of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, CA, USA.
Zhenni
Z
Guo
Departments of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, CA, USA.
Ting
T
Xu
Departments of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, CA, USA.
Jiping
J
Tang
Departments of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, CA, USA; Department of Neurosurgery, Loma Linda University School of Medicine, Loma Linda, CA, USA.
John H
0000-0002-4319-4285
JH
Zhang
hyperbaric oxygen preconditioning; ischemic stroke; neonatal hypoxic-ischemia; neuroprotection; traumatic brain injury