AMPK Regulation of Cell Growth, Apoptosis, Autophagy, and Bioenergetics.
In eukaryotic cells, AMP-activated protein kinase (AMPK) generally promotes catabolic pathways that produce ATP and at the same time inhibits anabolic pathways involved in different processes that consume ATP. As an energy sensor, AMPK is involved in the main cellular functions implicated in cell fate, such as cell growth and autophagy.Recently, AMPK has been connected with apoptosis regulation, although the molecular mechanism by which AMPK induces and/or inhibits cell death is not clear.This chapter reviews the essential role of AMPK in signaling pathways that respond to cellular stress and damage, highlighting the complex and reciprocal regulation between AMPK and their targets and effectors. The therapeutic implications of the role of AMPK in different pathologies such as diabetes, cancer, or mitochondrial dysfunctions are still controversial, and it is necessary to further investigate the molecular mechanisms underlying AMPK activation.
Centro Andaluz de Biología de Desarrollo (CABD), Universidad Pablo de Olavide-CSIC-Junta de Andalucía, 41013, Sevilla, Spain.|Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), ISCIII, Madrid, Spain.
Marina
M
Villanueva-Paz
Centro Andaluz de Biología de Desarrollo (CABD), Universidad Pablo de Olavide-CSIC-Junta de Andalucía, 41013, Sevilla, Spain.|Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), ISCIII, Madrid, Spain.
David
D
Cotán
Centro Andaluz de Biología de Desarrollo (CABD), Universidad Pablo de Olavide-CSIC-Junta de Andalucía, 41013, Sevilla, Spain.|Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), ISCIII, Madrid, Spain.
Juan
J
Garrido-Maraver
Centro Andaluz de Biología de Desarrollo (CABD), Universidad Pablo de Olavide-CSIC-Junta de Andalucía, 41013, Sevilla, Spain.|Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), ISCIII, Madrid, Spain.
Manuel
M
Oropesa-Ávila
Centro Andaluz de Biología de Desarrollo (CABD), Universidad Pablo de Olavide-CSIC-Junta de Andalucía, 41013, Sevilla, Spain.|Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), ISCIII, Madrid, Spain.
Mario
M
de la Mata
Centro Andaluz de Biología de Desarrollo (CABD), Universidad Pablo de Olavide-CSIC-Junta de Andalucía, 41013, Sevilla, Spain.|Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), ISCIII, Madrid, Spain.
Ana
A
Delgado-Pavón
Centro Andaluz de Biología de Desarrollo (CABD), Universidad Pablo de Olavide-CSIC-Junta de Andalucía, 41013, Sevilla, Spain.|Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), ISCIII, Madrid, Spain.
Isabel
I
de Lavera
Centro Andaluz de Biología de Desarrollo (CABD), Universidad Pablo de Olavide-CSIC-Junta de Andalucía, 41013, Sevilla, Spain.|Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), ISCIII, Madrid, Spain.
Elizabet
E
Alcocer-Gómez
Centro Andaluz de Biología de Desarrollo (CABD), Universidad Pablo de Olavide-CSIC-Junta de Andalucía, 41013, Sevilla, Spain.|Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), ISCIII, Madrid, Spain.
Mónica
M
Álvarez-Córdoba
Centro Andaluz de Biología de Desarrollo (CABD), Universidad Pablo de Olavide-CSIC-Junta de Andalucía, 41013, Sevilla, Spain. jasanalc@upo.es.|Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), ISCIII, Madrid, Spain. jasanalc@upo.es.
José  A
JA
Sánchez-Alcázar
D055372:AMP-Activated Protein Kinases / Q000235:genetics* / Q000378:metabolism; D017209:Apoptosis / Q000235:genetics*; D001343:Autophagy / Q000235:genetics*; D059447:Cell Cycle Checkpoints / Q000235:genetics; D049109:Cell Proliferation; D004734:Energy Metabolism / Q000235:genetics*; D005057:Eukaryotic Cells / Q000166:cytology / Q000201:enzymology*; D005227:Fatty Acids / Q000378:metabolism; D005786:Gene Expression Regulation; D005947:Glucose / Q000378:metabolism; D006801:Humans; D050155:Lipogenesis / Q000235:genetics; D048670:MAP Kinase Kinase 4 / Q000235:genetics / Q000378:metabolism; D000076222:Mechanistic Target of Rapamycin Complex 1; D046912:Multiprotein Complexes / Q000235:genetics / Q000378:metabolism; D021122:Protein Subunits / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D058570:TOR Serine-Threonine Kinases / Q000235:genetics / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism; D056811:Unfolded Protein Response / Q000235:genetics
D005227:Fatty Acids; D046912:Multiprotein Complexes; D021122:Protein Subunits; D016159:Tumor Suppressor Protein p53; D000076222:Mechanistic Target of Rapamycin Complex 1; D058570:TOR Serine-Threonine Kinases; D055372:AMP-Activated Protein Kinases; D048670:MAP Kinase Kinase 4; D005947:Glucose
AMPK; Apoptosis; Autophagy; Bioenergetics; Cell growth