Intramolecular cyclization of diarylmethanols and α,β-unsaturated amides promoted by KOt-Bu/DMF: a metal-free approach towards 3,4-disubstituted quinolinones.
A facile synthesis of quinolinones through intramolecular addition of diarylmethanols to α,β-unsaturated amides promoted by KOt-Bu/DMF is reported. A series of 3,4-disubstituted quinolinones were obtained in moderate to good yields. A reaction pathway via the ketyl radical is proposed.
Institute of Drug Synthesis and Pharmaceutical Process, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. zhangxj33@mail.sysu.edu.cn.
Jia-Hua
JH
Chen
Institute of Drug Synthesis and Pharmaceutical Process, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. zhangxj33@mail.sysu.edu.cn.
Zi-Cong
ZC
Chen
Institute of Drug Synthesis and Pharmaceutical Process, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. zhangxj33@mail.sysu.edu.cn.
Hong
H
Zhao
Institute of Drug Synthesis and Pharmaceutical Process, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. zhangxj33@mail.sysu.edu.cn.
Yong
Y
Zou
Institute of Drug Synthesis and Pharmaceutical Process, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. zhangxj33@mail.sysu.edu.cn.
Xue-Jing
XJ
Zhang
Institute of Drug Synthesis and Pharmaceutical Process, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. zhangxj33@mail.sysu.edu.cn.
Ming
M
Yan