Pharmacometrics-based decision tools facilitate mHealth implementation.
The healthcare system is experiencing a paradigm shift in delivering its services, evolving from a reactive 'one size-fits-all' structure to a patient-centric model focusing on individualized medicine. This change is driven by scientific progress, including quantitative evaluation and optimization of treatment strategies through pharmacometric approaches, harnessing the power of the digital revolution. Areas covered: This review describes four main steps to apply pharmacometrics-based decision support tools, consisting of validated scientific components, available technical options, consideration of regulatory aspects, and achievement of efficient commercialization. Examples of pharmacometrics-based decision tools that support monitoring of patients and individualization of treatment strategies in neonates, children and adults are presented. Expert commentary: We envision that user-friendly decision support tools will facilitate implementation of mobile health approaches (mHealth) realizing benefits to paediatric and adult patients and their caregivers.
a NSERC-Industrial Chair in Pharmacometrics, Full Professor, Faculty of Pharmacy , Université de Montréal , Montreal , Qc , Canada.
Fahima
F
Nekka
b Division of Pharmacology and Toxicology , Lausanne University Hospital, Head Research Unit , Lausanne , Switzerland.
Chantal
C
Csajka
c Pharmacometrician , University Children's Hospital Basel (UKBB), Paediatric Pharmacology and Pharmacometrics , Basel , Switzerland.
Mélanie
M
Wilbaux
d Rudraya Corporation , North Brunswick , NJ , USA.
Sachin
S
Sanduja
e Faculty of Pharmacy , Université de Montréal , Montreal , Qc , Canada.
Jun
J
Li
f Vice-Chair Paediatric Pharmacology and Pharmacometrics , University Children's Hospital Basel (UKBB) , Basel , Switzerland.
Marc
M
Pfister
D000328:Adult; D002648:Child; D003661:Decision Support Techniques; D003695:Delivery of Health Care / Q000458:organization & administration*; D006801:Humans; D007231:Infant, Newborn; D018802:Patient-Centered Care / Q000458:organization & administration; D004364:Pharmaceutical Preparations / Q000008:administration & dosage; D057285:Precision Medicine; D017216:Telemedicine / Q000458:organization & administration*
D004364:Pharmaceutical Preparations
bench-to-bed-translation; clinical pharmacology; computer modeling; decision support tools; digital technology; mHealth; personalised health; pharmacometrics; precision medicine