Phenyliodonium diacetate mediated carbotrifluoromethylation of N-acylhydrazones.
A concise, efficient and direct trifluoromethylation method of aldehyde-derived N-acylhydrazones has been firstly developed by using the combination of inexpensive, stable and commercially available TMSCF3and PhI(OAc)2as the CF3source under mild reaction conditions. This method provides easy access to highly functionalized trifluoromethylated N-acylhydrazones, which could be used as trifluoromethyl synthetic building blocks to be further transformed into other valuable trifluoromethyl compounds.
College of Chemistry and Chemical Engineering, Northwest Normal University, 967 Anning East Road, Lanzhou 730070, P. R. China. huyl@nwnu.edu.cn.
Weigang
W
Zhang
College of Chemistry and Chemical Engineering, Northwest Normal University, 967 Anning East Road, Lanzhou 730070, P. R. China. huyl@nwnu.edu.cn.
Yingpeng
http://orcid.org/0000-0002-4396-4198
Y
Su
College of Chemistry and Chemical Engineering, Northwest Normal University, 967 Anning East Road, Lanzhou 730070, P. R. China. huyl@nwnu.edu.cn.
Siying
S
Chong
College of Chemistry and Chemical Engineering, Northwest Normal University, 967 Anning East Road, Lanzhou 730070, P. R. China. huyl@nwnu.edu.cn.
Lili
L
Wu
College of Chemistry and Chemical Engineering, Northwest Normal University, 967 Anning East Road, Lanzhou 730070, P. R. China. huyl@nwnu.edu.cn.
Guiyan
G
Cao
College of Chemistry and Chemical Engineering, Northwest Normal University, 967 Anning East Road, Lanzhou 730070, P. R. China. huyl@nwnu.edu.cn.
Danfeng
D
Huang
College of Chemistry and Chemical Engineering, Northwest Normal University, 967 Anning East Road, Lanzhou 730070, P. R. China. huyl@nwnu.edu.cn.
Ke-Hu
KH
Wang
College of Chemistry and Chemical Engineering, Northwest Normal University, 967 Anning East Road, Lanzhou 730070, P. R. China. huyl@nwnu.edu.cn and State Key Laboratory of Applied Organic Chemistry, Lanzhou University, 222 Tianshui South Road, Lanzhou 730000, P. R. China.
Yulai
http://orcid.org/0000-0002-9630-4150
Y
Hu