Coconut Shell Liquid Smoke Promotes Burn Wound Healing.
The aim of this study was to evaluate burn wound healing activity of coconut shell liquid smoke (CS-LS) in a burn wound animal model. Burn wound-induced mice were treated with CS-LS (CS-LS group), povidone iodine 10% (povidone group), or NaCl 0.9% (NaCl group). Application of CS-LS promoted wound contraction compared to that of the povidone and NaCl groups ( P < .05). This study showed a positive correlation between the number of fibroblasts and wound contraction. The number of fibroblasts was highest in the CS-LS group, compared to that of the povidone and NaCl groups ( P < .05). In conclusion, CS-LS promotes burn wound healing by one possible mechanism, by increasing the number of fibroblasts. The results indicate that further experimental trials are needed to develop CS-LS as an alternative topical drug for burn wound healing.
1 Universitas Padjadjaran, Bandung, Indonesia.
Vita Murniati
VM
Tarawan
1 Universitas Padjadjaran, Bandung, Indonesia.
Kemala Isnainiasih
KI
Mantilidewi
1 Universitas Padjadjaran, Bandung, Indonesia.
Ika Miqra
IM
Dhini
1 Universitas Padjadjaran, Bandung, Indonesia.
Putri Teesa
PT
Radhiyanti
1 Universitas Padjadjaran, Bandung, Indonesia.|2 Dr. Hasan Sadikin Hospital, Bandung, Indonesia.
Endang
E
Sutedja
D000818:Animals; D002056:Burns / Q000188:drug therapy*; D003059:Cocos; D005347:Fibroblasts / Q000187:drug effects; D008297:Male; D051379:Mice; D011206:Povidone-Iodine / Q000627:therapeutic use; D012906:Smoke; D014945:Wound Healing / Q000187:drug effects*
D012906:Smoke; D011206:Povidone-Iodine
burn wound; coconut shell liquid smoke; fibroblast; wound contraction