Haploid Human Embryonic Stem Cells: Half the Genome, Double the Value.
Recent advances in the generation of haploid embryonic stem cells (ESCs), capable of self-renewal and differentiation, have laid the groundwork for numerous biomedical applications in developmental biology and reproductive medicine. When combined with the power of genetic screening, haploid human ESCs could advance cancer research, regenerative medicine, and disease modeling.
The Azrieli Center for Stem Cells and Genetic Research, Department of Genetics, Silberman Institute of Life Sciences, The Hebrew University, Jerusalem 91904, Israel.
Atilgan
A
Yilmaz
The Azrieli Center for Stem Cells and Genetic Research, Department of Genetics, Silberman Institute of Life Sciences, The Hebrew University, Jerusalem 91904, Israel.
Mordecai
M
Peretz
The Azrieli Center for Stem Cells and Genetic Research, Department of Genetics, Silberman Institute of Life Sciences, The Hebrew University, Jerusalem 91904, Israel. Electronic address: ido.sagi@mail.huji.ac.il.
Ido
I
Sagi
The Azrieli Center for Stem Cells and Genetic Research, Department of Genetics, Silberman Institute of Life Sciences, The Hebrew University, Jerusalem 91904, Israel. Electronic address: nissimb@mail.huji.ac.il.
Nissim
N
Benvenisty
D005820:Genetic Testing; D015894:Genome, Human; D006238:Haploidy; D000066449:Human Embryonic Stem Cells / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D018456:Reproductive Medicine