Primary Cutaneous Mucormycosis Caused by Rhizopus oryzae: A Case Report and Review of Literature.
Mucormycosis is an invasive infection caused by opportunistic fungi. Rhizopus, Lichtheimia, Mucor and Rhizomucor are the most common isolated genera. Primary cutaneous mucormycosis is usually related to traumatic injuries, but immunocompromised cases are associated with underlying conditions such as diabetes mellitus and malignancies. The treatment of choice is surgical debridement and liposomal amphotericin B. We present a 40-year-old male with fever and a painful necrotic lesion on the middle back and history of poorly controlled diabetes mellitus. Rhizopus oryzae was isolated and identified using an internal transcribed spacer regions ITS1 and ITS2. An initial good response to treatment was observed; however, 7 days later a diabetic ketoacidosis due to poor adherence to treatment caused a lethal outcome.
Servicio de Dermatología, Hospital General Dr. Manuel Gea González, 14080, Tlalpan, Mexico.
Erika
E
Rodríguez-Lobato
Servicio de Dermatología, Hospital General Dr. Manuel Gea González, 14080, Tlalpan, Mexico.
Lourdes
L
Ramírez-Hobak
Departamento Medicina Interna, Hospital General Dr. Manuel Gea González, 14080, Tlalpan, Mexico.
Jorge E
JE
Aquino-Matus
Departamento de Infectología, Hospital General Dr. Manuel Gea González, 14080, Tlalpan, Mexico.
Juan P
JP
Ramírez-Hinojosa
Departamento de Infectología, Hospital General Dr. Manuel Gea González, 14080, Tlalpan, Mexico.
Víctor H
VH
Lozano-Fernández
Laboratorio de Bacteriología Intestinal, Hospital Infantil de México Dr. Federico Gómez, 06720, Cuauhtémoc, Mexico.
Juan
J
Xicohtencatl-Cortes
Departamento de Ecología de Agentes Patógenos, Hospital General Dr. Manuel Gea González, Sección XVI, 14080, Tlalpan, Mexico. rhc@unam.mx.
Rigoberto
R
Hernández-Castro
Sección de Micología, Hospital General Dr. Manuel Gea González, Sección XVI, 14080, Tlalpan, Mexico.
Roberto
R
Arenas
D000328:Adult; D004271:DNA, Fungal / Q000737:chemistry / Q000235:genetics; D021903:DNA, Ribosomal Spacer / Q000737:chemistry / Q000235:genetics; D003881:Dermatomycoses / Q000175:diagnosis* / Q000382:microbiology / Q000473:pathology*; D048909:Diabetes Complications / Q000175:diagnosis / Q000382:microbiology / Q000473:pathology; D006651:Histocytochemistry; D006801:Humans; D008297:Male; D008853:Microscopy; D009091:Mucormycosis / Q000175:diagnosis* / Q000382:microbiology / Q000473:pathology*; D012233:Rhizopus / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D017422:Sequence Analysis, DNA; D012867:Skin / Q000382:microbiology / Q000473:pathology
D004271:DNA, Fungal; D021903:DNA, Ribosomal Spacer
Opportunistic fungal infection; Primary cutaneous mucormycosis; Rhizopus oryzae