Ulcer area reduction at 2 weeks predicts failure to heal by 24 weeks in the venous leg ulcers of patients living alone.
OBJECTIVE
Chronic wounds are costly and affect approximately 1-2% of the population. Venous disease is responsible for about 60% of all chronic leg ulcers and these ulcers can be debilitating, with evidence of a decreased quality of life. Unfortunately, up to 30% of venous leg ulcers (VLUs) fail to heal, despite best practice treatment. This study aimed to identify risk factors associated with delayed healing in participants with VLUs and in particular, whether psychosocial factors play a part in this process.


METHODS
A secondary analysis was conducted of a large data set of clinical, wound healing, health, social, economic and psychological data collected in previous prospective studies of participants with VLUs. Generalised linear mixed modelling was used to identify independent predictors of failure to heal after 24 weeks.


RESULTS
We recruited 247 participants with 318 VLUs from hospital and community settings. Findings revealed that four early predictors were independently significantly associated with failure to heal by 24 weeks. These were: participants who lived alone (OR 2.3, 95%CI [1.13-4.61], p=0.03); had less than 25% reduction in ulcer area within two weeks of treatment (OR 10.07, 95%CI [4.60-22.19], p<0.001); had higher ulcer severity scores (OR 5.1, 95%CI [2.33-11.88], p=0.001); and participants who were not treated with high level compression therapy (i.e.>30 mmHg) at the time of assessment (OR 4.18, 95% CI [1.95-8.97], p=0.002).


CONCLUSIONS
Identified risk factors offer an opportunity for clinicians to determine realistic outcomes for their patients and to guide decisions on early referral and implementation of tailored adjunctive interventions. Additionally, findings from this study suggest health professionals need to assess and address not only clinical risk factors but also social risk factors, when planning interventions to promote healing.
Assistant Dean (International and Engagement), School of Nursing, Queensland University of Technology, Victoria Park Road, Kelvin Grove, QLD, 4059 Australia.|Assistant Dean (International and Engagement), Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue Kelvin Grove, QLD, 4059 Australia.|Assistant Dean (International and Engagement), Faculty of Health, Queensland University of Technology, Victoria Park Road, Kelvin Grove, QLD 4059 Australia.|Assistant Dean (International and Engagement), Wound Management Innovation Cooperative Research Centre, Oxley House, Level 2, 25 Donkin Street West End, QLD 4101 Australia.
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CN
Parker
Assistant Dean (International and Engagement), School of Nursing, Queensland University of Technology, Victoria Park Road, Kelvin Grove, QLD, 4059 Australia.|Assistant Dean (International and Engagement), Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue Kelvin Grove, QLD, 4059 Australia.|Assistant Dean (International and Engagement), Faculty of Health, Queensland University of Technology, Victoria Park Road, Kelvin Grove, QLD 4059 Australia.|Assistant Dean (International and Engagement), Wound Management Innovation Cooperative Research Centre, Oxley House, Level 2, 25 Donkin Street West End, QLD 4101 Australia.
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KJ
Finlayson
Assistant Dean (International and Engagement), Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue Kelvin Grove, QLD, 4059 Australia.|Assistant Dean (International and Engagement), Faculty of Health, Queensland University of Technology, Victoria Park Road, Kelvin Grove, QLD 4059 Australia.|Assistant Dean (International and Engagement), Wound Management Innovation Cooperative Research Centre, Oxley House, Level 2, 25 Donkin Street West End, QLD 4101 Australia.
H E
HE
Edwards
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D058128:Compression Bandages; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors; D012648:Self Care; D017211:Treatment Failure; D014647:Varicose Ulcer / Q000628:therapy*; D014945:Wound Healing / Q000502:physiology*
delayed healing; generalised linear mixed modelling; living alone; non-healing; risk factors; venous leg ulcer