Association of insulin resistance with breast, ovarian, endometrial and cervical cancers in non-diabetic women.
Hyperinsulinemia and insulin resistance were reported to play a crucial role in diabetes-cancer relationship. This study aimed to explore the associations between insulin resistance and several female cancers in a non-diabetic population. This cross-sectional study was conducted in 121,230 middle-aged and elderly non-diabetic women. Cancer diagnosis was self-reported and further validated by medical records. Insulin resistance was defined as homeostasis model assessment of insulin resistance (HOMA-IR) ≥ 2.50. The prevalence of both premenopausal and postmenopausal breast cancer, postmenopausal ovarian cancer and premenopausal endometrial cancer were higher in insulin-resistant participants than in insulin-sensitive participants (premenopausal breast cancer, 0.45 vs 0.28%; postmenopausal breast cancer, 0.86 vs 0.63%; postmenopausal ovarian cancer, 0.17 vs 0.09%; premenopausal endometrial cancer, 0.43 vs 0.25%, respectively, allP < 0.05). Individuals with insulin resistance had higher odds ratio (OR) of breast cancer, both premenopausal and postmenopausal (OR 1.98, 95% confidence interval (CI) 1.19-3.32; OR 1.29, 95% CI 1.01-1.63), postmenopausal ovarian cancer (OR 2.17, 95% CI 1.10-3.40) as well as total endometrial cancer (OR 1.47, 95% CI 1.02-2.12). Subgroup analysis revealed that the possitive association between insulin resistance and risk of prevalent breast cancer was observed in popualtion with younger age, overweight or obesity, higher education and impaired glucose tolerance (IGR). No relationships were observed for the risk of prevalent cervical cancers with insulin resistance. Non-diabetic women with insulin resistance had higher risk of prevalent breast, ovarian and endomatrial cancer, which suggests special attentions to these female cancer screening and prevention.
National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine Shanghai 200025, China.
Wanwan
W
Sun
National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine Shanghai 200025, China.
Jieli
J
Lu
Karamay Municipal People's Hospital Xinjiang 834000, China.
Shengli
S
Wu
National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine Shanghai 200025, China.
Yufang
Y
Bi
Chinese People's Liberation Army General Hospital Beijing 100000, China.
Yiming
Y
Mu
Shandong Provincial Hospital Affiliated to Shandong University Jinan 250000, China.
Jiajun
J
Zhao
Jiangsu Province Hospital on Integration of Chinese and Western Medicine Nanjing 210000, China.
Chao
C
Liu
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan 430000, China.
Lulu
L
Chen
Affiliated Hospital of Guiyang Medical College Guiyang 550000, China.
Lixin
L
Shi
The Second Affiliated Hospital of Harbin Medical University Harbin 150000, China.
Qiang
Q
Li
The First Affiliated Hospital with Nanjing Medical University, Jiangsu Province Hospital Nanjing 210000, China.
Tao
T
Yang
Sun Yat-sen Memorial Hospital, Sun Yat-sen University Guangzhou 510000, China.
Li
L
Yan
The Affiliated Hospital of Luzhou Medical College Luzhou 646000, China.
Qin
Q
Wan
The First Hospital of Jilin University Changchun 130000, China.
Yan
Y
Liu
The First Hospital of Jilin University Changchun 130000, China.
Guixia
G
Wang
The First Affiliated Hospital of Guangxi Medical University Nanning 530000, China.
Zuojie
Z
Luo
The First Hospital of Lanzhou University Lanzhou 730000, China.
Xulei
X
Tang
Fujian Provincial Hospital, Fujian Medical University Fuzhou 350000, China.
Gang
G
Chen
Jiangxi People's Hospital Nanchang 330000, China.
Yanan
Y
Huo
Dalian Municipal Central Hospital Dalian 116000, China.
Zhengnan
Z
Gao
Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine Shanghai 200082, China.
Qing
Q
Su
Zhejiang Provincial Center for Disease Control and Prevention Zhejiang 314000, China.
Zhen
Z
Ye
The First Affiliated Hospital of Anhui Medical University Hefei 230000, China.
Youmin
Y
Wang
The First Affiliated Hospital of Zhengzhou University Zhengzhou 450000, China.
Guijun
G
Qin
The First Affiliated Hospital of Chongqing Medical University Chongqing 400000, China.
Huacong
H
Deng
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan 430000, China.
Xuefeng
X
Yu
The First Affiliated Hospital of Wenzhou Medical University Wenzhou 325000, China.
Feixia
F
Shen
Qilu Hospital of Shandong University Jinan 250000, China.
Li
L
Chen
National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine Shanghai 200025, China.
Liebin
L
Zhao
National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine Shanghai 200025, China.
Tiange
T
Wang
National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of MedicineShanghai 200025, China; Laboratory of Endocrine and Metabolic Diseases, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, and Shanghai Jiao Tong University School of MedicineShanghai 200030,China.
Jichao
J
Sun
National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine Shanghai 200025, China.
Min
M
Xu
National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine Shanghai 200025, China.
Yu
Y
Xu
National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine Shanghai 200025, China.
Yuhong
Y
Chen
National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine Shanghai 200025, China.
Meng
M
Dai
National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine Shanghai 200025, China.
Jie
J
Zhang
National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine Shanghai 200025, China.
Di
D
Zhang
National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of MedicineShanghai 200025, China; Johns Hopkins University School of MedicineBaltimore, Maryland 21201, USA.
Shenghan
S
Lai
Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center Houston, Texas 77036, USA.
Donghui
D
Li
National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of MedicineShanghai 200025, China; Laboratory of Endocrine and Metabolic Diseases, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, and Shanghai Jiao Tong University School of MedicineShanghai 200030,China.
Guang
G
Ning
National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine Shanghai 200025, China.
Weiqing
W
Wang
Insulin resistance; breast; endometrial and cervical cancers; non-diabetic; ovarian