Varioloid A, a new indolyl-6,10b-dihydro-5aH-[1]benzofuro[2,3-b]indole derivative from the marine alga-derived endophytic fungusPaecilomyces variotiiEN-291.
A new indolyl-6,10b-dihydro-5aH-[1]benzofuro[2,3-b]indole derivative, varioloid A (1), was isolated from the marine alga-derived endophytic fungusPaecilomyces variotiiEN-291. Its structure was elucidated on the basis of extensive analysis of 1D and 2D NMR data and the absolute configuration was determined by time-dependent density functional theory-electronic circular dichroism (TDDFT-ECD) calculations. A similar compound, whose planar structure was previously described but the relative and absolute configurations and13C NMR data were not reported, was also identified and was tentatively named as varioloid B (2). Both compounds1and2exhibited cytotoxicity against A549, HCT116, and HepG2 cell lines, with IC50values ranging from 2.6 to 8.2 µg/mL.
Laboratory of Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, China, ; Tobacco Research Institute of Chinese Academy of Agricultural Sciences, Qingdao 266101, China.
Peng
P
Zhang
Laboratory of Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, China.
Xiao-Ming
XM
Li
Tobacco Research Institute of Chinese Academy of Agricultural Sciences, Qingdao 266101, China.
Xin-Xin
XX
Mao
Department of Organic Chemistry, University of Debrecen, P. O. Box 400, 4002 Debrecen, Hungary.
Attila
A
Mándi
Department of Organic Chemistry, University of Debrecen, P. O. Box 400, 4002 Debrecen, Hungary.
Tibor
T
Kurtán
Laboratory of Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, China.
Bin-Gui
BG
Wang
Paecilomyces variotii; TDDFT-ECD calculation; bisindolyl benzenoid derivatives; cytotoxicity; marine alga-derived fungus