Pharmacokinetic dose adjustment of 5-FU in modified FOLFOX7 plus bevacizumab for metastatic colorectal cancer in Japanese patients: a-JUST phase II clinical trial.
OBJECTIVE
Dose adjustment of 5-fluorouracil (FU) based on pharmacokinetic monitoring has been shown to reduce toxicities and increase efficacy compared with dosing based on body surface area in patients with metastatic colorectal cancer (mCRC). We evaluated the efficacy and safety of pharmacokinetic dose adjustment of FU in a modified FOLFOX7 (mFOLFOX7) plus bevacizumab regimen in Japanese patients with previously untreated mCRC.


METHODS
This single-arm, multicenter phase II trial enrolled 48 patients with mCRC. Treatment consisted of 5 mg/kg intravenous bevacizumab followed by mFOLFOX7 (oxaliplatin 85 mg/m2on day 1, infused leucovorin 200 mg/m2, followed by a 2400 mg/m2infusion of FU for 46 h starting on day 1), repeated every 2 weeks. FU concentrations were measured by immunoassay between 18 and 36 h after the start of continuous FU infusion, and the FU dose was then adjusted if required in subsequent cycles. The primary endpoint was response rate.


RESULTS
The median initial area under the concentration-time curve for FU was 23 mg h/L. Twenty-nine patients (60%) achieved the target concentration at the first cycle, and all 48 achieved it within the fourth cycle. The overall frequency of grade 3/4 adverse effects was 38%, with no significant difference between patients who did and not require dose adjustments. The overall response rate was 48% (95% confidence intervals = 34-62%). The median progression-free and overall survival rates were 11.3 and 24.1 months, respectively.


CONCLUSIONS
Pharmacokinetic dose adjustment of FU in mFOLFOX7 plus bevacizumab can optimize FU concentrations promptly and is safe in Japanese patients with mCRC.
Division of Gastroenterology, Chiba Cancer Center, Chiba, Japan.
Tadamichi
T
Denda
Department of Gastroenterological Surgery (Surgery II), Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan. m-kanda@med.nagoya-u.ac.jp.
Mitsuro
M
Kanda
Department of Radiology, Kobe Medical Center, Kobe, Japan.
Yoshitaka
Y
Morita
Department of Surgery, Rinku General Medical Center, Izumisano, Japan.
Ho Min
HM
Kim
Division of Cancer Center, Saga University Hospital, Saga, Japan.
Tomomi
T
Kashiwada
Department of Surgery, Osaka General Medical Center, Osaka, Japan.
Chu
C
Matsuda
Division of Gastroenterology, Ibaraki Prefectural Hospital, Kasama, Japan.
Shinji
S
Fujieda
Department of Surgery, Sakai City Hospital, Sakai, Japan.
Ken
K
Nakata
Clinical Research Center, Aichi Medical University Hospital, Nagakute, Japan.
Kenta
K
Murotani
Department of Biostatistics, School of Public Health, Tokyo University Graduate School of Medicine, Tokyo, Japan.|Interfaculty Initiative in Information Studies, Tokyo University, Tokyo, Japan.
Koji
K
Oba
Tokai Central Hospital, Gifu, Japan.
Junichi
J
Sakamoto
Cancer Center, Aichi Medical University, Nagakute, Japan.
Hideyuki
H
Mishima
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D000068258:Bevacizumab / Q000008:administration & dosage; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000493:pharmacokinetics; D006801:Humans; D002955:Leucovorin; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009944:Organoplatinum Compounds
D009944:Organoplatinum Compounds; D000068258:Bevacizumab; D002955:Leucovorin; D005472:Fluorouracil
5-Fluorouracil; Colorectal cancer; Dose adjustment; Pharmacokinetics; Phase II trial; mFOLFOX