Chorea and parkinsonism associated with autoantibodies to IgLON5 and responsive to immunotherapy.
Encephalopathy associated with autoantibodies to IgLON5 is a novel syndrome characterized by a distinct sleep disorder and brain-stem involvement. Since the initial description of this encephalopathy in 2014, only a few additional patients have been reported (Simabukuro et al., 2015). In this paper, we report a new case of anti-IgLON5 antibodies with major symptoms of chorea and parkinsonism, and responsive to immunotherapy.
Department of Neurology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China.
Ren
R
Haitao
Department of Neurology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China.
Yang
Y
Yingmai
Department of Neurology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China.
Huang
H
Yan
Department of Neurology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China.
Han
H
Fei
Department of Neurology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China.
Lv
L
Xia
Department of Neurology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China.
Hao
H
Honglin
Department of Neurology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China.
Liu
L
Chaiyan
Institute for Experimental Immunology, Euroimmun AG, Lübeck, Germany.
Winfried
W
Stöcker
Department of Neurology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China; Neuroscience Center, Chinese Academy of Medical Sciences, Beijing 100730, China.
Cui
C
Liying
Department of Neurology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China. Electronic address: guanhz@263.net.
Guan
G
Hongzhi
D001323:Autoantibodies / Q000097:blood*; D015816:Cell Adhesion Molecules, Neuronal / Q000097:blood*; D002819:Chorea / Q000097:blood* / Q000175:diagnosis / Q000188:drug therapy; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage*; D007167:Immunotherapy / Q000379:methods*; D008875:Middle Aged; D020734:Parkinsonian Disorders / Q000097:blood* / Q000175:diagnosis / Q000188:drug therapy
D001323:Autoantibodies; D015816:Cell Adhesion Molecules, Neuronal; C000591569:IgLON5 protein, human; D016756:Immunoglobulins, Intravenous