Human ex-vivo oral tissue imaging using spectral domain polarization sensitive optical coherence tomography.
We report the use of spectral domain polarization sensitive optical coherence tomography for ex-vivo imaging of human oral mandibular tissue samples. Our results show that compared to the changes observed in the epithelium thickness and the decay constant of A-scan intensity profile, a much larger degree of change was observed in the phase retardation for tissue sites progressing from normal to the malignant state. These results suggest that monitoring of tissue retardance can help in better differentiation of normal and cancerous oral tissue sites.
Laser Biomedical Applications Section, Raja Ramanna Centre for Advanced Technology, Indore, 452013, India. priyanka@rrcat.gov.in.|Homi Bhabha National Institute, Mumbai, 400094, India. priyanka@rrcat.gov.in.
Priyanka
P
Sharma
Laser Biomedical Applications Section, Raja Ramanna Centre for Advanced Technology, Indore, 452013, India.|Wellman Center for Photomedicine, Harvard Medical School and Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114, USA.
Yogesh
Y
Verma
Laser Biomedical Applications Section, Raja Ramanna Centre for Advanced Technology, Indore, 452013, India.
Khageswar
K
Sahu
Laser Biomedical Applications Section, Raja Ramanna Centre for Advanced Technology, Indore, 452013, India.
Sudhir
S
Kumar
Sri Aurobindo Medical College and P. G. Institute, Indore, 452013, India.
Amit V
AV
Varma
Laser Biomedical Applications Section, Raja Ramanna Centre for Advanced Technology, Indore, 452013, India.
Jyoti
J
Kumawat
Homi Bhabha National Institute, Mumbai, 400094, India.
Pradeep Kumar
PK
Gupta
D002138:Calibration; D003094:Collagen / Q000378:metabolism; D006801:Humans; D009055:Mouth / Q000473:pathology*; D012044:Regression Analysis; D012542:Scattering, Radiation; D041623:Tomography, Optical Coherence / Q000379:methods*
D003094:Collagen
Collagen; Optical coherence tomography; Oral cancer; Spectral domain polarization sensitive optical coherence tomography; Submucosal fibrosis; Trichrome staining