Development and characterization of resveratrol nanoemulsions carrying dual-imaging agents.
Delivery of the natural anti-inflammatory compound resveratrol with nanoemulsions can dramatically improve its tissue targeting, bioavailability and efficacy. Current assessment of resveratrol delivery efficacy is limited to indirect pharmacological measures. Molecular imaging solves this problem. Results/methodology: Nanoemulsions containing two complementary imaging agents, near-infrared dye and perfluoropolyether (PFPE), were developed and evaluated. Nanoemulsion effects on macrophage uptake, toxicity and NO production were also evaluated. The presence of PFPE did not affect nanoemulsion size, zeta potential, colloidal stability, drug loading or drug release.



PFPE nanoemulsions can be used in future studies to evaluate nanoemulsion biodistribution without interfering with resveratrol delivery and pharmacological outcomes. Developed nanoemulsions show promise as a versatile treatment strategy for cancer and other inflammatory diseases. [Formula: see text].
Graduate School of Pharmaceutical Sciences, Mylan School of Pharmacy, Duquesne University, Pittsburgh, PA 15282, USA.
Michele
M
Herneisey
Graduate School of Pharmaceutical Sciences, Mylan School of Pharmacy, Duquesne University, Pittsburgh, PA 15282, USA.
Jonathan
J
Williams
Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia.
Janja
J
Mirtic
Graduate School of Pharmaceutical Sciences, Mylan School of Pharmacy, Duquesne University, Pittsburgh, PA 15282, USA.
Lu
L
Liu
Graduate School of Pharmaceutical Sciences, Mylan School of Pharmacy, Duquesne University, Pittsburgh, PA 15282, USA.
Sneha
S
Potdar
Graduate School of Pharmaceutical Sciences, Mylan School of Pharmacy, Duquesne University, Pittsburgh, PA 15282, USA.
Christina
C
Bagia
Graduate School of Pharmaceutical Sciences, Mylan School of Pharmacy, Duquesne University, Pittsburgh, PA 15282, USA.
Jane E
JE
Cavanaugh
Graduate School of Pharmaceutical Sciences, Mylan School of Pharmacy, Duquesne University, Pittsburgh, PA 15282, USA.|Chronic Pain Research Consortium, Duquesne University, Pittsburgh, PA 15282, USA.|McGowan Institute for Regenerative Medicine, University of Pittsburgh, PA 15219, USA.
Jelena M
JM
Janjic
D001682:Biological Availability; D004655:Emulsions; D057054:Molecular Imaging; D000077185:Resveratrol; D013267:Stilbenes; D014018:Tissue Distribution
D004655:Emulsions; D013267:Stilbenes; D000077185:Resveratrol
macrophage; nanoemulsion; perfluorocarbon; perfluoropolyether; resveratrol; theranostic