Antibody profiles induced by Trypanosoma cruzi in chagasic patients with previous or current exposure to mycobacteria.
Since the immune response mounted by the host to a particular microorganism might be influenced by the acquired immunological experience due to previous contact with other microorganisms, we performed a cross-sectional study to explore the pattern of Trypanosoma cruzi infection-related antibodies in T. cruzi-seropositive individuals presenting concomitant tuberculosis, or the antecedent of BCG vaccination. Sampled individuals were grouped as follows: patients with Chagas disease, not vaccinated with BCG, who further developed pulmonary tuberculosis; individuals with Chagas disease, BCG-vaccinated; and subjects with Chagas disease, presenting neither BCG scar nor tuberculosis disease. Non-vaccinated individuals or without tuberculosis, presented the highest values of anti-PH (P < 0.001), anti-FRA (P < 0.001), anti-p2β (P = 0.0023) and anti-B13 (P < 0.001) antibodies. The present findings constitute the first demonstration of the potential influence of concomitant tuberculosis on Chagas disease.
Laboratorio de Tecnología Inmunológica, Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina.
Luz
L
Peverengo
Laboratorio de Tecnología Inmunológica, Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina.
Estefanía
E
Prochetto
Laboratorio de Tecnología Inmunológica, Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina.|Facultad de Ciencias Médicas, Universidad Nacional del Litoral, Santa Fe, Argentina.
Luz
L
Rodeles
Facultad de Ciencias Médicas, Universidad Nacional del Litoral, Santa Fe, Argentina.
Ignacio
I
Valenzuela
Laboratorio de Tecnología Inmunológica, Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina.
Iván Sergio
IS
Marcipar
Instituto de Inmunología Clínica y Experimental de Rosario, UNR-CONICET, Santa Fe, Argentina.
Oscar
O
Bottasso
Laboratorio de Tecnología Inmunológica, Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina mvicco@santafe-conicet.gov.ar.|Facultad de Ciencias Médicas, Universidad Nacional del Litoral, Santa Fe, Argentina.
Miguel Hernán
MH
Vicco
D000913:Antibodies, Protozoan / Q000097:blood / Q000276:immunology*; D014355:Chagas Disease / Q000276:immunology* / Q000382:microbiology / Q000469:parasitology; D060085:Coinfection; D006790:Host-Parasite Interactions / Q000276:immunology; D054884:Host-Pathogen Interactions / Q000276:immunology; D006801:Humans; D009161:Mycobacterium / Q000276:immunology*; D009164:Mycobacterium Infections / Q000276:immunology* / Q000382:microbiology; D014349:Trypanosoma cruzi / Q000276:immunology*
D000913:Antibodies, Protozoan
BCG vaccination; Chagas disease; tuberculosis