Comparison of indocyanine green angiography and optical coherence tomographic angiography in polypoidal choroidal vasculopathy.
PurposeTo compare optical coherence tomographic angiography (OCTA) and indocyanine green angiography (ICGA) images for detecting polypoidal lesions (PLs) and branching vascular networks (BVNs), and to measure the polypoidal areas (PAs) in patients with polypoidal choroidal vasculopathy (PCV).MethodsAll patients underwent ICGA, optical coherence tomography (OCT), and OCTA. We compared the detection sensitivity for PL and BVN, as evaluated by the ICGA and OCTA images. Furthermore, PA measured by ICGA was divided into two groups: one in which the area could be measured by OCTA (ICGA+OCTA+) and the other in which the area could not be measured by OCTA (ICGA+OCTA-).ResultsTwenty-one consecutive eyes of 21 patients (mean age, 73.8±9.8 years) were included. ICGA detected PL in all eyes (100%), whereas OCTA detected PL in 16 eyes (75.2%); ICGA detected BVN in 15 eyes (71.4%), whereas OCTA detected BVN in 20 eyes (95.2%). The mean PA in ICGA+OCTA+and ICGA+OCTA-was 0.24±0.04 and 0.14±0.01 mm2, respectively; a significant difference was observed between ICGA+OCTA+PA and ICGA+OCTA-PA (P<0.0001). In addition, the mean PA in the ICGA+OCTA+group measured by ICGA and OCTA was 0.24±0.04 was 0.19±0.04 mm2, respectively; these values were significantly different (P=0.0046).ConclusionsOCTA might detect more BVNs and fewer PLs compared with ICGA, and PL detected by OCTA might be smaller than those detected by ICGA.
Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
K
K
Takayama
Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Y
Y
Ito
Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
H
H
Kaneko
Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
K
K
Kataoka
Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
T
T
Sugita
Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
R
R
Maruko
Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
K
K
Hattori
Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
E
E
Ra
Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
F
F
Haga
Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
H
H
Terasaki
D000368:Aged; D000369:Aged, 80 and over; D002829:Choroid / Q000098:blood supply* / Q000473:pathology; D015862:Choroid Diseases / Q000000981:diagnostic imaging* / Q000473:pathology; D020256:Choroidal Neovascularization / Q000000981:diagnostic imaging; D004396:Coloring Agents / Q000008:administration & dosage; D005260:Female; D005451:Fluorescein Angiography / Q000379:methods*; D006801:Humans; D007208:Indocyanine Green / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D061848:Optical Imaging / Q000379:methods*; D011127:Polyps / Q000000981:diagnostic imaging*; D041623:Tomography, Optical Coherence / Q000379:methods*
D004396:Coloring Agents; D007208:Indocyanine Green