The dual clastogenic and anti-clastogenic properties of quercetin is dose dependent.
Iron is a ubiquitous constituent of cytochromes, oxygen-binding molecules and a variety of enzymes because of its property to transition from ferric (Fe3+) to ferrous (Fe2+) state, leading to change in the redox potential. However, the same property accounts for free radical injury. In order to overcome harmful effects of iron we investigated the possible protective effect of quercetin (QCT), a flavonoid with antioxidant property, against the oxidative DNA damage caused by iron sulfatein vivo. We show that QCT exerts efficient anticlastogenic action in the context of iron sulfate treatment up to a dose of 500 mg/kg while it induces DNA damage at higher doses. These findings show that QCT has a dual effect; at low doses it ameliorates the oxidative damage produced by iron, and it is genotoxic and cytotoxic at a higher dose.
Program in Biochemistry, Sackler School of Graduate Biomedical Sciences, Tufts University, and Program in Cell and Molecular Physiology, Sackler School of Graduate Biomedical Sciences, Tufts University, and Department of Developmental, Molecular and Chemi.
Nuzhat
N
Parveen
Cytogenetics and Molecular Toxicology Lab, Section of Genetics, Department of Zoology, Aligarh Muslim University, Aligarh, PO Box 202002, UP, India, gghas.amu@gmail.com.
Ghulam Gha
GG
Shadab
D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology; D002869:Chromosome Aberrations / Q000187:drug effects; D004249:DNA Damage; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005296:Ferrous Compounds / Q000633:toxicity; D008297:Male; D015162:Micronucleus Tests; D009153:Mutagens / Q000008:administration & dosage / Q000494:pharmacology; D010084:Oxidation-Reduction; D011794:Quercetin / Q000008:administration & dosage* / Q000494:pharmacology; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
D000975:Antioxidants; D005296:Ferrous Compounds; D009153:Mutagens; C020748:ferrous sulfate; D011794:Quercetin