Incidence and characteristics of chronic renal replacement therapy in patients with cancer: data from kidney and cancer registries in Basse-Normandie.
Aims To estimate the incidence of chronic dialysis in patients with a history of cancer and assess how renal replacement therapy is initiated in this population. Methods We merged data from cancer registries and hospital databases in one French region to identify patients with an incident cancer between 2001 and 2008 who started chronic dialysis. Results Mean participation time was 3.4 ± 2.7 years. Males comprised 58.5 % of participants. During the study period, 74 chronic dialysis treatments were initiated. Chronic interstitial nephritis was the leading cause of end-stage renal disease (21.6 %), and 46.6 % of dialysis initiation cases were unplanned. The incidence rate of chronic dialysis initiation in the population of incident cancer patients was 370 per million population/year (74 events/199,809 person-years). After age-adjustment, the standardized incidence ratio was 1.26, 95 % confidence interval 0.98-1.57, p = 0.55. Conclusion Cancer patients are known to be at risk of chronic kidney disease. However, the standardized incidence ratio of chronic dialysis initiation did not differ significantly between cancer patients and the general population. Further studies should be performed to identify the barriers to starting renal replacement therapy in cancer patients.
CHU de Caen, Avenue de la Côte de Nacre, 14033, Caen Cedex, France. bechade-c@chu-caen.fr.|Cancers and Preventions, U1086 INSERM-UCBN, Centre François Baclesse, Caen, France. bechade-c@chu-caen.fr.
Clémence
C
Béchade
CHU de Caen, Avenue de la Côte de Nacre, 14033, Caen Cedex, France.|Cancers and Preventions, U1086 INSERM-UCBN, Centre François Baclesse, Caen, France.
Olivier
O
Dejardin
Francim: Réseau Français des Registres des Cancers, Toulouse, France.|Manche Cancer Registry, Hôpital du Cotentin, Cherbourg-Octeville, France.
Simona
S
Bara
CHU de Caen, Avenue de la Côte de Nacre, 14033, Caen Cedex, France.|Cancers and Preventions, U1086 INSERM-UCBN, Centre François Baclesse, Caen, France.|Calvados Digestive Cancer Registry, Cancers and Preventions, U 1086 Inserm, Centre François Baclesse, Caen, France.
Véronique
V
Bouvier
Cancers and Preventions, U1086 INSERM-UCBN, Centre François Baclesse, Caen, France.|Calvados General Cancer Registry, Cancers and Preventions, U 1086 Inserm, Centre François Baclesse, Caen, France.
Anne-Valérie
AV
Guizard
CHU de Caen, Avenue de la Côte de Nacre, 14033, Caen Cedex, France.|Cancers and Preventions, U1086 INSERM-UCBN, Centre François Baclesse, Caen, France.
Rémy
R
De Mil
CHU de Caen, Avenue de la Côte de Nacre, 14033, Caen Cedex, France.|Francim: Réseau Français des Registres des Cancers, Toulouse, France.|Basse-Normandie Haematological Malignancies Cancer Registry, CHU de Caen, Avenue de la Côte de Nacre, 14033, Caen Cedex, France.
Xavier
X
Troussard
CHU de Caen, Avenue de la Côte de Nacre, 14033, Caen Cedex, France.|Cancers and Preventions, U1086 INSERM-UCBN, Centre François Baclesse, Caen, France.
Thierry
T
Lobbedez
CHU de Caen, Avenue de la Côte de Nacre, 14033, Caen Cedex, France.|Cancers and Preventions, U1086 INSERM-UCBN, Centre François Baclesse, Caen, France.
Guy
G
Launoy
D000368:Aged; D000369:Aged, 80 and over; D016208:Databases, Factual; D005602:France / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D053208:Kaplan-Meier Estimate; D007676:Kidney Failure, Chronic / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy*; D008875:Middle Aged; D009369:Neoplasms / Q000175:diagnosis / Q000453:epidemiology*; D009395:Nephritis, Interstitial / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy*; D012042:Registries; D006435:Renal Dialysis / Q000009:adverse effects; D051436:Renal Insufficiency, Chronic / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy*; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors; D061665:Time-to-Treatment; D016896:Treatment Outcome
Cancer; Dialysis; Incidence; Renal replacement therapy