Cognitive remediation to enhance mobility in older adults: the CREM study.
Mobility disabilities represent the most prevalent disability among seniors. Emerging evidence indicates that executive functions play an important role in maintaining mobility. However, the use of cognitive remediation programs to enhance mobility has not been investigated in a full-scale randomized control trial. The CREM study is a single-blind randomized control trial to examine the effect of computerized cognitive remediation versus computer-based health education training on mobility in 420 seniors. The primary outcome is change in gait speed during normal walking and walking-while-talking conditions from baseline to postintervention. Secondary outcomes are change in mobility, mobility-related cognitive processes and neuroplasticity. Results of this study will fill an important gap in the efficacy and feasibility of cognitive remediation to improve mobility in seniors.
Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA.|Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA.
Joe
J
Verghese
Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA.
Emmeline
E
Ayers
Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA.
Jeannette R
JR
Mahoney
Burke Rehabilitation Hospital, White Plains, NY, USA.
Anne
A
Ambrose
Department of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.
Cuiling
C
Wang
Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA.|Ferkauf Graduate School of Psychology of Yeshiva University, Bronx, NY, USA.
Roee
R
Holtzer
D000368:Aged; D000369:Aged, 80 and over; D000072466:Cognitive Remediation; D056344:Executive Function; D005684:Gait; D020233:Gait Disorders, Neurologic / Q000175:diagnosis / Q000628:therapy*; D006801:Humans; D051346:Mobility Limitation; D018579:Patient Selection; D016037:Single-Blind Method; D013813:Therapy, Computer-Assisted; D016138:Walking
clinical trial protocol; cognitive remediation; executive function; gait velocity