Adhesion GPCRs Govern Polarity of Epithelia and Cell Migration.
In multicellular organisms cells spatially arrange in a highly coordinated manner to form tissues and organs, which is essential for the function of an organism. The component cells and resulting structures are often polarised in one or more axes, and how such polarity is established and maintained correctly has been one of the major biological questions for many decades. Research progress has shown that many adhesion GPCRs (aGPCRs) are involved in several types of polarity. Members of the two evolutionarily oldest groups, Flamingo/Celsr and Latrophilins, are key molecules in planar cell polarity of epithelia or the propagation of cellular polarity in the early embryo, respectively. Other adhesion GPCRs play essential roles in cell migration, indicating that this receptor class includes essential molecules for the control of various levels of cellular organisation.
Bateson Centre and Department of Biomedical Science, University of Sheffield, Sheffield, UK. d.strutt@sheffield.ac.uk.
David
D
Strutt
Institute of Genetics, TU Braunschweig, Braunschweig, Germany. r.schnabel@tu-bs.de.
Ralf
R
Schnabel
Medical Faculty, Institute of Biochemistry, Leipzig University, Leipzig, Germany.
Franziska
F
Fiedler
Medical Faculty, Institute of Biochemistry, Leipzig University, Leipzig, Germany. simone.proemel@medizin.uni-leipzig.de.
Simone
S
Prömel
D000818:Animals; D001665:Binding Sites; D015820:Cadherins / Q000378:metabolism; D002448:Cell Adhesion; D015815:Cell Adhesion Molecules / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism*; D002465:Cell Movement; D016764:Cell Polarity; D004847:Epithelial Cells / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D008024:Ligands; D008958:Models, Molecular; D009024:Morphogenesis; D011485:Protein Binding; D054730:Protein Interaction Domains and Motifs; D043562:Receptors, G-Protein-Coupled / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D018000:Receptors, Peptide / Q000378:metabolism; D015398:Signal Transduction; D013329:Structure-Activity Relationship
C454220:CELSR1 cadherin, human; D015820:Cadherins; D015815:Cell Adhesion Molecules; D008024:Ligands; D043562:Receptors, G-Protein-Coupled; D018000:Receptors, Peptide; C034800:alpha-latrotoxin receptor