Intrathoracic neurogenic tumor with malignant transition-20 years operation experience in a medical center of China.
Malignant peripheral neurogenic tumor is always found in large peripheral nerve of the extremities, however, benign peripheral neurogenic tumors of chest is an uncommon disorder, furthermore, malignant transition is even rare. So far, few cases have been reported. We studied 45 neurogenic thoracic tumors patients with malignant transition.



We retrospectively reviewed clinical data of 45 malignant neurogenic thoracic tumors from 1992 to 2012, including 11 (24.44%) cases of borderline tumors (group X), 13 cases of (28.88%) low-grade malignant tumor (group L), and 21 cases (46.66%) of malignant tumors (group M). Specifically, we reviewed the clinical characteristics, surgical approach, postoperative outcome, complications and prognosis of these patients.



All tumors are located in the thoracic cavity, and arising from sympathetic or spinal nerve or their branches from the lung or posterior mediastinum. The patients from groups X and L had more complete resection than group M. Unfortunately, one patient was dead intra operatively in Group M. Group M had more recurrence than groups X and L. Our results indicates that, the survival rate may be correlated with tumor size, malignant degree (P=0.018), tumor recurrence and incomplete resection (P<0.05).



The most effective treatment method for these tumors is early identification and resection by minimally invasive surgery during benign stage. In addition, regarding low-grade malignant tumor, non-radical surgery could also be responsible for the low survival rate.
Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Medical School of Tongji University, Zhengmin Road 507, Shanghai, 200433, China.
Chenlu
C
Yang
Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Medical School of Tongji University, Zhengmin Road 507, Shanghai, 200433, China.
Deping
D
Zhao
Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Medical School of Tongji University, Zhengmin Road 507, Shanghai, 200433, China.
Peng
P
Zhang
Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Medical School of Tongji University, Zhengmin Road 507, Shanghai, 200433, China.
Ke
K
Fei
Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Medical School of Tongji University, Zhengmin Road 507, Shanghai, 200433, China. Electronic address: 13917599730@163.com.
Gening
G
Jiang
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D002681:China; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D009380:Neoplasms, Nerve Tissue / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate; D013899:Thoracic Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D016896:Treatment Outcome; D055815:Young Adult
Clinical manifestations; Malignant neurogenic tumors; Outcome; Surgical treatment