Roles of SIRT3 in heart failure: from bench to bedside.
Heart failure (HF) represents the most common endpoint of most cardiovascular diseases (CVDs) which are the leading causes of death around the world. Despite the advances in treating CVDs, the prevalence of HF continues to increase. It is believed that better results of prognosis are obtained from prevention rather than additional treatment for HF. Therefore, it is reasonable to prevent the development of CVDs or other complications to HF. Most types of HF are attributed to contractile dysfunction, cardiac hypertrophy or remodeling, and ischemic injuries. SIRT3 is a mitochondrial nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase whose substrates vary from metabolic biogenesis-associated proteins to stress-responsive proteins. In recent years, a number of studies have highlighted the cardio-protective role of SIRT3 and, as such, efforts have been made to induce over-expression or increased activity of this protein. In this review, we provide an overview of the roles of SIRT3 in cardiac hypertrophy induced by pressure overload or agonists and cardiomyocytes ischemic injuries. Moreover, we will introduce the application of SIRT3 agonists in the prevention of cardiac hypertrophy and ischemia reperfusion injury.
Department of Cardiology, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China.|Provincial Key Laboratory of Cardiovascular Research of Zhejiang Province, Hangzhou 310009, China.|Department of Cardiology, Ningbo Medical Center Lihuili Eastern Hospital, Ningbo 315100, China.
De-Xing
DX
Hu
Department of Cardiology, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China.|Provincial Key Laboratory of Cardiovascular Research of Zhejiang Province, Hangzhou 310009, China.
Xian-Bao
XB
Liu
Department of Cardiology, Ningbo Medical Center Lihuili Eastern Hospital, Ningbo 315100, China.
Wen-Chao
WC
Song
Department of Cardiology, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China.|Provincial Key Laboratory of Cardiovascular Research of Zhejiang Province, Hangzhou 310009, China.
Jian-An
JA
Wang
D000818:Animals; D006332:Cardiomegaly / Q000517:prevention & control; D006333:Heart Failure / Q000209:etiology*; D006801:Humans; D015428:Myocardial Reperfusion Injury / Q000517:prevention & control; D017382:Reactive Oxygen Species / Q000378:metabolism; D056566:Sirtuin 3 / Q000502:physiology*
D017382:Reactive Oxygen Species; C466093:SIRT3 protein, human; D056566:Sirtuin 3
Heart failure; Hypertrophy; Ischemia reperfusion; SIRT3