Evaluation of the chemical quality of Sekkoku () in current Japanese commercial crude drugs: constituents of Flickingeria xantholeuca (Rchb. f.) A.D. Hawkes.
In our investigation, most Shihu (; Japanese name, Sekkoku) in current Japanese commercial crude drugs were from Flickingeria xantholeuca (Orchidaceae). As the index compounds, three new ent-pimarane-type diterpenes, flickinxthanthosides A-C (1-3), one known analogue (7), and three new ent-kaurane-type diterpenes, flickinxanthosides D (4) and E (5) and flickinxanthol A (6) were isolated from the stem of F. xantholeuca. The structures of the new compounds were elucidated on the basis of spectroscopic analyses and chemical methods. We attempted to detect these index compounds from the MeOH extracts of other Dendrobium or Flickingeria plants using TLC and LC/MS.
Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka, 569-1094, Japan.
Mei
M
Muto
National Defense Medicinal College, 3-2 Namiki, Tokorozawa, Saitama, 359-8513, Japan.
Haruka
H
Asahina
Research Institute of Medicinal Plant Resources, Shinnihonseiyaku Co., Ltd., 275 Hongo-machi, Iwakuni, Yamaguchi, 740-0602, Japan.
Tatsufumi
T
Yoshioka
Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka, 569-1094, Japan.
Kazuo
K
Ozaki
Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka, 569-1094, Japan. shibano@gly.oups.ac.jp.
Makio
http://orcid.org/0000-0002-3612-3673
M
Shibano
D004224:Diterpenes / Q000737:chemistry; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D007564:Japan; D015394:Molecular Structure; D029595:Orchidaceae / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry*
D004224:Diterpenes; D004365:Drugs, Chinese Herbal; D010936:Plant Extracts
Flickingeria xantholeuca; Glycoside; LC/MS; Orchidaceae; TLC; ent-Kaurane-type diterpene; ent-Pimarane-type diterpene