Metastasis-associated long noncoding RNAs in gastrointestinal cancer: Implications for novel biomarkers and therapeutic targets.
Long non-coding RNAs (lncRNAs), a newly discovered class of ncRNA molecules, have been widely accepted as crucial regulators of various diseases including cancer. Increasing numbers of studies have demonstrated that lncRNAs are involved in diverse physiological and pathophysiological processes, such as cell cycle progression, chromatin remodeling, gene transcription, and posttranscriptional processing. Aberrant expression of lncRNAs frequently occurs in gastrointestinal cancer and plays emerging roles in cancer metastasis. In this review, we focus on and outline the regulatory functions of recently identified metastasis-associated lncRNAs, and evaluate the potential roles of lncRNAs as novel diagnostic biomarkers and therapeutic targets in gastrointestinal cancer.
Fei-Fei Zhang, Yu-Hao Luo, Liang Zhao, Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou 510000, Guangdong Province, China.
Fei-Fei
FF
Zhang
Fei-Fei Zhang, Yu-Hao Luo, Liang Zhao, Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou 510000, Guangdong Province, China.
Yu-Hao
YH
Luo
Fei-Fei Zhang, Yu-Hao Luo, Liang Zhao, Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou 510000, Guangdong Province, China.
Hui
H
Wang
Fei-Fei Zhang, Yu-Hao Luo, Liang Zhao, Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou 510000, Guangdong Province, China.
Liang
L
Zhao
D014408:Biomarkers, Tumor / Q000235:genetics*; D002467:Cell Nucleus / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D005770:Gastrointestinal Neoplasms / Q000235:genetics*; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009362:Neoplasm Metastasis; D014176:Protein Biosynthesis; D062085:RNA, Long Noncoding / Q000235:genetics* / Q000378:metabolism; D022661:RNA, Untranslated
D014408:Biomarkers, Tumor; C094335:H19 long non-coding RNA; C561566:HOTAIR long untranslated RNA, human; C557041:MALAT1 long non-coding RNA, human; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated
Epithelial-to-mesenchymal transition; Gastrointestinal cancer; Long noncoding RNAs; MicroRNAs; Tumor metastasis