Inhibiting macrophage PI3Kγ to enhance immunotherapy.
A recent paper published in Nature reports that the immunosuppressive activity of tumor-associated macrophages is regulated via PI3Kγ signaling. Small-molecule inhibitors targeting PI3Kγ stimulate T cell activity against tumor alone and add additional effects for clinically proven PD1 immunotherapy.
Department of Developmental and Molecular Biology, Albert Einstein College of Medicine and Montefiore Medical Center, New York, NY 10461, USA.
Wei
W
Zheng
Department of Developmental and Molecular Biology, Albert Einstein College of Medicine and Montefiore Medical Center, New York, NY 10461, USA.|MRC Centre for Reproductive Health, Queen's Medical Research Institute, The University of Edinburgh, Edinburgh EH16 4TJ, UK.
Jeffrey W
JW
Pollard
D006801:Humans; D007165:Immunosuppression Therapy; D007167:Immunotherapy; D008264:Macrophages / Q000276:immunology*; D009369:Neoplasms; D015398:Signal Transduction