Prevalence and Risk Factors for Toxoplasmosis in Middle Java, Indonesia.
Toxoplasmosis is a zoonosis caused by Toxoplasma gondii. Risk factors include consumption of undercooked meat, raw vegetables, and unfiltered water. This study aims to determine the seroprevalence and spatial distribution of toxoplasmosis in Middle Java, Indonesia, using an EcoHealth approach, combined with geographic information system (GIS). A total of 630 participants were randomly selected from seven districts. Each participant completed a questionnaire and provided a blood sample. The seroprevalence of toxoplasmosis was 62.5%. Of those who were seropositive, 90.1% were IgG+, and 9.9% were IgG+ and IgM+. Several risk factors were identified, including living at elevations of ≤200 m, compared with >200 m (OR = 56.2; P < 0.001), daily contact with raw meat (OR = 1.8; P = 0.001), unfiltered water (OR = 1.7; P = 0.003), and density of cats (OR = 1.4; P = 0.045). Visualizing the spatial distribution of seropositive respondents highlighted clustering in lowland areas. This study highlighted that Middle Java has a high prevalence of toxoplasmosis and identified some important environmental, ecological, and demographic risk factors. When researching diseases, such as toxoplasmosis, where animal hosts, human lifestyle, and environmental factors are involved in transmission, an EcoHealth method is essential to ensure a fully collaborative approach to developing interventions to reduce the risk of transmission in high-risk populations.
Postgraduate Program of Tropical Medicine, Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia.|EcoHealth Resource Center (EHRC)-Universitas Gadjah Mada, Yogyakarta, Indonesia.
Annisa
A
Retmanasari
Departement of GISRP, Faculty of Geography, Universitas Gadjah Mada, Yogyakarta, Indonesia.
Barandi Sapta
BS
Widartono
Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia.
Mahardika Agus
MA
Wijayanti
Departement of Biochemistry, Medical Veterinary Faculty, Universitas Gadjah Mada, Jl. Fauna 2 Karangmalang, Yogyakarta, 55281, Indonesia. artama@ugm.ac.id.|EcoHealth Resource Center (EHRC)-Universitas Gadjah Mada, Yogyakarta, Indonesia. artama@ugm.ac.id.
Wayan Tunas
WT
Artama
D000818:Animals; D000913:Antibodies, Protozoan / Q000097:blood; D002415:Cats; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D007214:Indonesia; D015995:Prevalence; D012307:Risk Factors; D016036:Seroepidemiologic Studies; D014122:Toxoplasma; D014123:Toxoplasmosis / Q000097:blood / Q000453:epidemiology*
D000913:Antibodies, Protozoan; D007074:Immunoglobulin G; D007075:Immunoglobulin M
EcoHealth; geographic information system (GIS); risk factors; seroprevalence; toxoplasmosis