A new synthesis and preliminary evaluation of some analogues of mecamylamine - a compound with anti-addiction properties.
A new synthesis of mecamylamine - a known anti-hypertensive drug with anti-addictive properties is described. The new route allowed access to two novel analogues whose activity at two nicotinic acetylcholine receptor subtypes was assessed.
Trinity Biomedical Sciences Institute, School of Chemistry, The University of Dublin, Trinity College, Dublin 2, Ireland. southerj@tcd.ie.
David
D
Mangan
Trinity Biomedical Sciences Institute, School of Chemistry, The University of Dublin, Trinity College, Dublin 2, Ireland. southerj@tcd.ie.
Neasa
N
McNabola
Department of Biology & Biochemistry, University of Bath, Bath BA2 7AY, UK.
Emily H
EH
Clark
School of Life Sciences, Oxford Brookes University, Oxford OX3 0BP, UK.
Isabel
I
Bermudez
Department of Biology & Biochemistry, University of Bath, Bath BA2 7AY, UK.
Susan
S
Wonnacott
Trinity Biomedical Sciences Institute, School of Chemistry, The University of Dublin, Trinity College, Dublin 2, Ireland. southerj@tcd.ie.
J Mike
JM
Southern
D000959:Antihypertensive Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D016739:Behavior, Addictive / Q000188:drug therapy*; D060326:Chemistry Techniques, Synthetic; D008464:Mecamylamine / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D008745:Methylation; D011978:Receptors, Nicotinic / Q000378:metabolism
D000959:Antihypertensive Agents; D011978:Receptors, Nicotinic; D008464:Mecamylamine