Advances in allergen immunotherapy in 2015.
The year 2015 saw a significant number of advances in allergen immunotherapy (AIT), and several of these are reviewed in this report. Although AIT has been used for more than 100 years, investigations into optimal treatment approaches and mechanisms are ongoing. Among the highlights was a report by an international group of experts who reviewed AIT guidelines from the major specialty societies and addressed potential unmet needs. Herein, advances in the effectiveness, safety, and mechanisms of sublingual and oral immunotherapy are reviewed. Development of hypoallergenic vaccines to enhance safety, newer routes and regimens to improve efficacy, and biomarkers to monitor immunotherapy are also discussed.
Division of Allergy, Pulmonary, Critical Care, and Sleep Medicine, University of Wisconsin, Madison, Wis. Electronic address: rkb@medicine.wisc.edu.
Robert K
RK
Bush
D000818:Animals; D001249:Asthma / Q000628:therapy; D015415:Biomarkers; D003888:Desensitization, Immunologic; D005512:Food Hypersensitivity / Q000628:therapy; D006801:Humans; D065631:Rhinitis, Allergic / Q000628:therapy; D014612:Vaccines / Q000627:therapeutic use
D015415:Biomarkers; D014612:Vaccines
Allergen immunotherapy; clinical trials; immunotherapy