Statistics for Sleep and Biological Rhythms Research.
This article is part of a Journal of Biological Rhythms series exploring analysis and statistical topics relevant to researchers in biological rhythms and sleep research. The goal is to provide an overview of the most common issues that arise in the analysis and interpretation of data in these fields. In this article, we address issues related to the collection of multiple data points from the same organism or system at different times, since such longitudinal data collection is fundamental to the assessment of biological rhythms. Rhythmic longitudinal data require additional specific statistical considerations, ranging from curve fitting to threshold definitions to accounting for correlation structure. We discuss statistical analyses of longitudinal data including issues of correlational structure and stationarity, markers of biological rhythms, demasking of biological rhythms, and determining phase, waveform, and amplitude of biological rhythms.
Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts.|Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, Massachusetts.
Elizabeth B
EB
Klerman
Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts.|Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, Massachusetts.
Wei
W
Wang
Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts.|Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, Massachusetts.
Andrew J K
AJ
Phillips
Neurology Department, Massachusetts General Hospital, Boston, Massachusetts.|Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts.
Matt T
MT
Bianchi
D000818:Animals; D015415:Biomarkers / Q000032:analysis; D035843:Biomedical Research / Q000379:methods*; D002940:Circadian Rhythm / Q000502:physiology*; D003625:Data Collection / Q000379:methods / Q000706:statistics & numerical data; D006801:Humans; D008954:Models, Biological; D012890:Sleep / Q000502:physiology*; D013223:Statistics as Topic / Q000379:methods*; D013997:Time Factors
D015415:Biomarkers
biological rhythms; circadian rhythms; longitudinal analyses; periodicity; statistics