Fat mass obesity-associated (FTO) (rs9939609) and melanocortin 4 receptor (MC4R) (rs17782313) SNP are positively associated with obesity and blood pressure in Mexican school-aged children.
Childhood overweight and obesity are worldwide public health problems and risk factors for chronic diseases. The presence of SNP in several genes has been associated with the presence of obesity. A total of 580 children (8-13 years old) from Queretaro, Mexico, participated in this cross-sectional study, which evaluated the associations of rs9939609 (fat mass obesity-associated (FTO)), rs17782313 (melanocortin 4 receptor (MC4R)) and rs6548238 (transmembrane protein 18 (TMEM18)) SNP with obesity and metabolic risk factors. Overweight and obesity prevalence was 19·8 and 19·1 %, respectively.FTO,MC4RandTMEM18risk allele frequency was 17, 9·8 and 89·5 %, respectively. A significant association betweenFTOhomozygous andMC4Rheterozygous risk alleles and obesity was found (OR 3·9; 95 % CI 1·46, 10·22, and OR 2·1; 95 % CI 1·22, 3·71; respectively). TheFTOheterozygous subjects showed higher systolic and diastolic blood pressures, compared with the homozygous for the ancestral allele subjects. These results remain significant after considering adiposity as a covariate. TheFTOandMC4Rgenotypes were not significantly associated with total cholesterol, HDL-cholesterol and insulin concentration. No association was found betweenTMEM18risk allele and obesity and/or metabolic alterations. Our results show that, in addition to a higher BMI, there is also an association of the risk genotype with blood pressure in the presence of theFTOrisk genotype. The possible presence of a risk genotype in obese children must be considered to offer a more comprehensive therapeutic approach in order to delay and/or prevent the development of chronic diseases.
Departamento de Investigación Biomédica, Facultad de Medicina, Universidad Autónoma de Querétaro, Querétaro, Clavel 200, Col. Prados de la Capilla, Querétaro, Qro. CP 76170, México.
Pablo
P
García-Solís
Departamento de Investigación Biomédica, Facultad de Medicina, Universidad Autónoma de Querétaro, Querétaro, Clavel 200, Col. Prados de la Capilla, Querétaro, Qro. CP 76170, México.
Marissa
M
Reyes-Bastidas
Facultad de Ciencias Naturales, Universidad Autónoma de Querétaro, Av Ciencias S/N, Juriquilla, Qro. CP 76230, México.
Karla
K
Flores
Facultad de Ciencias Naturales, Universidad Autónoma de Querétaro, Av Ciencias S/N, Juriquilla, Qro. CP 76230, México.
Olga P
OP
García
Facultad de Ciencias Naturales, Universidad Autónoma de Querétaro, Av Ciencias S/N, Juriquilla, Qro. CP 76230, México.
Jorge L
JL
Rosado
Departamento de Investigación Biomédica, Facultad de Medicina, Universidad Autónoma de Querétaro, Querétaro, Clavel 200, Col. Prados de la Capilla, Querétaro, Qro. CP 76170, México.
Lorena
L
Méndez-Villa
Departamento de Investigación Biomédica, Facultad de Medicina, Universidad Autónoma de Querétaro, Querétaro, Clavel 200, Col. Prados de la Capilla, Querétaro, Qro. CP 76170, México.
Carlota
C
Garcia-G
Departamento de Investigación Biomédica, Facultad de Medicina, Universidad Autónoma de Querétaro, Querétaro, Clavel 200, Col. Prados de la Capilla, Querétaro, Qro. CP 76170, México.
David
D
García-Gutiérrez
Facultad de Ciencias Naturales, Universidad Autónoma de Querétaro, Av Ciencias S/N, Juriquilla, Qro. CP 76230, México.
Aarón
A
Kuri-García
Departamento de Investigación Biomédica, Facultad de Medicina, Universidad Autónoma de Querétaro, Querétaro, Clavel 200, Col. Prados de la Capilla, Querétaro, Qro. CP 76170, México.
Hebert L
HL
Hernández-Montiel
Departamento de Investigación Biomédica, Facultad de Medicina, Universidad Autónoma de Querétaro, Querétaro, Clavel 200, Col. Prados de la Capilla, Querétaro, Qro. CP 76170, México.
Ofelia
O
Soriano-Leon
Departamento de Investigación Biomédica, Facultad de Medicina, Universidad Autónoma de Querétaro, Querétaro, Clavel 200, Col. Prados de la Capilla, Querétaro, Qro. CP 76170, México.
Maria Elena
ME
Villagrán-Herrera
Departamento de Investigación Biomédica, Facultad de Medicina, Universidad Autónoma de Querétaro, Querétaro, Clavel 200, Col. Prados de la Capilla, Querétaro, Qro. CP 76170, México.
Juan C
JC
Solis-Sainz
Blood pressure; Fat mass obesity-associated; Melanocortin 4 receptor; Obesity; SNP