Secondary metabolites from Aspergillus japonicus CAM231, an endophytic fungus associated with Garcinia preussii.
Chemical investigation of Aspergillus japonicus CAM231, isolated from the leaf of Garcina preussii collected in Cameroon, yielded two new compounds; one pyrone derivative, hydroxy neovasinin (1) and one phenol derivative, asperolan (2), together with two known compounds neovasifurarone B (3) and variecolin (4). The structures of the two new compounds were established using intensive NMR spectroscopy and HRMS spectra in comparison with data found in literature. The structure of compound 1 was confirmed by single-crystal X-ray crystallographic analysis in combination with NOESY experiment. The new compounds were screened for their cytotoxic and antibacterial properties; however, the tested compounds displayed no significant activities.
a Department of Organic Chemistry, Faculty of Science , University of Yaoundé I , Yaoundé , Cameroon.
Jean-Bosco
JB
Jouda
b Department of Biochemistry, Faculty of Science , University of Yaoundé I , Yaoundé , Cameroon.
Judith-Laure Demgne
JD
Fopossi
b Department of Biochemistry, Faculty of Science , University of Yaoundé I , Yaoundé , Cameroon.
Francine Mediesse
FM
Kengne
a Department of Organic Chemistry, Faculty of Science , University of Yaoundé I , Yaoundé , Cameroon.
Céline
C
Djama Mbazoa
c Department of Chemistry and Chemical Biology, Inorganic Chemistry , TU Dortmund , Dortmund , Germany.
Christopher
C
Golz
c Department of Chemistry and Chemical Biology, Inorganic Chemistry , TU Dortmund , Dortmund , Germany.
Carsten
C
Strohmann
d Department of Chemistry , Higher Teachers' Training College, University of Yaoundé I , Yaoundé , Cameroon.
Simeon Kouam
SK
Fogue
a Department of Organic Chemistry, Faculty of Science , University of Yaoundé I , Yaoundé , Cameroon.
Jean
J
Wandji
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D001230:Aspergillus / Q000737:chemistry / Q000378:metabolism*; D001943:Breast Neoplasms / Q000188:drug therapy / Q000473:pathology; D002163:Cameroon; D045744:Cell Line, Tumor; D018360:Crystallography, X-Ray; D004353:Drug Evaluation, Preclinical; D060026:Endophytes / Q000378:metabolism; D005663:Furans / Q000302:isolation & purification*; D029760:Garcinia / Q000382:microbiology*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010636:Phenols / Q000302:isolation & purification*; D011753:Pyrones / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism; D064210:Secondary Metabolism; D013729:Terpenes / Q000302:isolation & purification / Q000378:metabolism
D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D005663:Furans; D010636:Phenols; D011753:Pyrones; D013729:Terpenes; C000619294:asperolan; C000619293:hydroxy neovasinin; C000619295:neovasifurarone B; C433945:variecolin
Aspergillus japonicus CAM231; endophytic fungus; secondary metabolites