Evaluation of superabsorbent linseed-polysaccharides as a novel stimuli-responsive oral sustained release drug delivery system.
BACKGROUND
Advancement in technology has transformed the conventional dosage forms to intelligent drug delivery systems. Such systems are helpful for targeted and efficient drug delivery with minimum side effects. Drug release from these systems is governed and controlled by external stimuli (pH, enzymes, ions, glucose, etc.). Polymeric biomaterial having stimuli-responsive properties has opened a new area in drug delivery approach.


OBJECTIVE
Potential of a polysaccharide (rhamnogalacturonan)-based hydrogel from Linseeds (Linum usitatissimum L.) was investigated as an intelligent drug delivery material.


METHODS
Different concentrations of Linseed hydrogel (LSH) were used to prepare caffeine and diacerein tablets and further investigated for pH and salt solution-responsive swelling, pH-dependent drug release, and release kinetics. Morphology of tablets was observed using SEM.


RESULTS
LSH tablets exhibited dynamic swelling-deswelling behavior with tendency to swell at pH 7.4 and in deionized water while deswell at pH 1.2, in normal saline and ethanol. Consequently, pH controlled release of the drugs was observed from tablets with lower release (<10%) at pH 1.2 and higher release at pH 6.8 and 7.4. SEM showed elongated channels in swollen then freeze-dried tablets.


CONCLUSIONS
The drug release was greatly influenced by the amount of LSH in the tablets. Drug release from LSH tablets was governed by the non-Fickian diffusion.


CONCLUSIONS
These finding indicates that LSH holds potential to be developed as sustained release material for tablet.
a Department of Pharmaceutics, Faculty of Pharmacy , University of Sargodha , Sargodha , Pakistan.
Muhammad Tahir
MT
Haseeb
b Department of Chemistry , University of Sargodha , Sargodha , Pakistan.
Muhammad Ajaz
MA
Hussain
a Department of Pharmaceutics, Faculty of Pharmacy , University of Sargodha , Sargodha , Pakistan.
Sajid
S
Bashir
a Department of Pharmaceutics, Faculty of Pharmacy , University of Sargodha , Sargodha , Pakistan.
Muhammad Umer
MU
Ashraf
c Faculty of Pharmacy, Centre for Drug Delivery Research , Universiti Kebangsaan Malaysia , Kuala Lumpur , Malaysia.
Naveed
N
Ahmad
D000284:Administration, Oral; D003692:Delayed-Action Preparations / Q000008:administration & dosage*; D016503:Drug Delivery Systems / Q000379:methods*; D004353:Drug Evaluation, Preclinical / Q000379:methods; D065546:Drug Liberation; D019597:Flax; D020100:Hydrogels / Q000008:administration & dosage / Q000737:chemistry; D011134:Polysaccharides / Q000008:administration & dosage*; D017550:Spectroscopy, Fourier Transform Infrared; D013607:Tablets
D003692:Delayed-Action Preparations; D020100:Hydrogels; D011134:Polysaccharides; D013607:Tablets
Linseed hydrogel; oral drug delivery; rhamnogalacturonan; stimuli-responsive material; sustained release