Protective effect of Sophoraflavanone G on streptozotocin (STZ)-induced inflammation in diabetic rats.
The present study was designed to investigate the protective effect of Sophoraflavanone G (SG) on streptozotocin (STZ)-induced diabetic rats. The rats were intraperitoneally injected with STZ (35mg/kg). 7days later, the rats were intragastrically administered with Metformin (MET, 150mg/kg), SG (20mg/kg) or SG (40mg/kg) once daily for consecutive 30 days. The animals were anaesthetized, the blood and liver samples were also collected for further assay. SG significantly decreased the serum levels of glucose, insulin, aspartate transaminase (AST), alanine aminotransferase (ALT). In addition, SG increased superoxide dismutase (SOD) activity and inhibited malondialdehyde (MDA) content in serum. SG also ameliorated the histopathological condition. Furthermore, SG attenuated the expressions of thioredoxin (Trx), thioredoxin-interacting protein (Txnip) and the phosphorylations of inhibitory kappa B kinase (IKK)α, IKKβ, nuclear factor-κB inhibitory proteins (IκB)α, nuclear factor κB (NF-κB). These findings demonstrated that SG showed beneficial effects on STZ-induced diabetic rats.
College of Pharmacy, Ningxia Medical University, 1160 Shengli Street, Yinchuan, Ningxia 750004, PR China. Electronic address: wwwhhq@163.com.
Hanqing
H
Wang
College of Pharmacy, Ningxia Medical University, 1160 Shengli Street, Yinchuan, Ningxia 750004, PR China.
Li
L
Chen
College of Pharmacy, Ningxia Medical University, 1160 Shengli Street, Yinchuan, Ningxia 750004, PR China.
Liming
L
Zhang
College of Pharmacy, Ningxia Medical University, 1160 Shengli Street, Yinchuan, Ningxia 750004, PR China.
Xiaojuan
X
Gao
College of Pharmacy, Ningxia Medical University, 1160 Shengli Street, Yinchuan, Ningxia 750004, PR China.
Yinghua
Y
Wang
Center for Translational Systems Biology and Neuroscience, School of Basic Biomedical Science, Nanjing University of Chinese Medicine, Nanjing 210023, PR China. Electronic address: taoweiweinanjing@126.com.
Tao
T
Weiwei
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D002352:Carrier Proteins / Q000378:metabolism; D018797:Cell Cycle Proteins; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D044950:Flavanones / Q000494:pharmacology / Q000627:therapeutic use*; D020672:I-kappa B Proteins / Q000378:metabolism; D007249:Inflammation / Q000097:blood / Q000150:complications / Q000188:drug therapy* / Q000473:pathology*; D007328:Insulin / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D016328:NF-kappa B / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects; D010766:Phosphorylation / Q000187:drug effects; D020011:Protective Agents / Q000494:pharmacology / Q000627:therapeutic use*; D017207:Rats, Sprague-Dawley; D013311:Streptozocin; D013482:Superoxide Dismutase / Q000097:blood; D013879:Thioredoxins / Q000378:metabolism
D001786:Blood Glucose; D002352:Carrier Proteins; D018797:Cell Cycle Proteins; D044950:Flavanones; D020672:I-kappa B Proteins; D007328:Insulin; D016328:NF-kappa B; D020011:Protective Agents; C493796:TXNIP protein, rat; D008315:Malondialdehyde; D013879:Thioredoxins; D013311:Streptozocin; C064849:vexibinol; D013482:Superoxide Dismutase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase
Oxidative stress; STZ; Sophoraflavanone G; Txnip/Trx/NF-κB