Fault Tree Analysis: Investigation of Epidemic Hemorrhagic Fever Infection Acquired in Animal Laboratories in China.
Epidemic hemorrhagic fever has been an ongoing threat to laboratory personnel involved in animal care and use. Laboratory transmissions and severe infections occurred over the past twenty years, even though the standards and regulations for laboratory biosafety have been issued, upgraded, and implemented in China. Therefore, there is an urgent need to identify risk factors and to seek effective preventive measures that can curb the incidences of epidemic hemorrhagic fever among laboratory personnel. In the present study, we reviewed literature that relevant to animals laboratory-acquired hemorrhagic fever infections reported from 1995 to 2015, and analyzed these incidences using fault tree analysis (FTA). The results of data analysis showed that purchasing of qualified animals and guarding against wild rats which could make sure the laboratory animals without hantaviruses, are the basic measures to prevent infections. During the process of daily management, the consciousness of personal protecting and the ability of personal protecting need to be further improved. Undoubtedly vaccination is the most direct and effective method, while it plays role after infection. So avoiding infections can't rely entirely on vaccination.
Laboratory management department, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
Xiao Yu
XY
Liu
Laboratory management department, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
Kang Ning
KN
Xue
Laboratory management department, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
Rong
R
Rong
Laboratory management department, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
Chi Hong
CH
Zhao
D000820:Animal Diseases / Q000635:transmission / Q000821:virology; D000818:Animals; D000830:Animals, Laboratory / Q000821:virology*; D002681:China; D004196:Disease Outbreaks; D006476:Orthohantavirus; D006480:Hemorrhagic Fever with Renal Syndrome / Q000453:epidemiology* / Q000635:transmission; D006801:Humans; D015994:Incidence; D059232:Laboratory Personnel; D051381:Rats