Mechanisms of protein aggregation and inhibition.
Protein and peptide aggregation raises keen interest due to their involvement in number of pathological conditions ranging from neurodegenerative disorders to systemic amyloidosis. Here, we have reviewed recent advances in mechanisms of aggregation, emerging technologies towards exploration, characterization of aggregate structures, detection at molecular level and the strategies to combat the phenomenon of aggregation both in cellular and in vitro conditions. In consistence, we have illustrated almost all factors that influence the protein aggregation both in vitro and in vivo environments. In addition, we have discussed a detailed journey of protein aggregation phenomenon that starts with very first events of protein aggregation. We had also described advancement in current scenarios, present aspects of fibril association to several life threatening disorders and current experimental strategies that are employed to oppose or reverse the amyloid formation.
Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh- 200202, India.
Mohammad Khursheed
MK
Siddiqi
Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh- 200202, India.
Parvez
P
Alam
Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh- 200202, India.
Sumit Kumar
SK
Chaturvedi
Molecular Biology Department, Genetic Engineering and Biotechnology Division, National Research Centre, Dokki, Cairo, Egypt.
Yasser E
YE
Shahein
Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh - 200202, India, rizwanhkhan@hotmail.com.
Rizwan Hasan
RH
Khan
D000682:Amyloid / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D066263:Protein Aggregation, Pathological; D017510:Protein Folding
D000682:Amyloid