Spaceflight induced changes in the human proteome.
Spaceflight is one of the most extreme conditions encountered by humans: Individuals are exposed to radiation, microgravity, hypodynamia, and will experience isolation. A better understanding of the molecular processes induced by these factors may allow us to develop personalized countermeasures to minimize risks to astronauts. Areas covered: This review is a summary of literature searches from PubMed, NASA, Roskosmos and the authors' research experiences and opinions. The review covers the available proteomic data on the effects of spaceflight factors on the human body, including both real space missions and ground-based model experiments. Expert commentary: Overall, the authors believe that the present background, methodology and equipment improvements will enhance spaceflight safety and support accumulation of new knowledge on how organisms adapt to extreme conditions.
a Institute of Biomedical Problems - Russian Federation State Scientific Research Center, Laboratory of proteomics , Russian Academy of Sciences , Moscow , Russia.|b Moscow Institute of Physics and Technology , Laboratory of ion and molecular physics , Moscow , Russia.|d V.L. Talrose Institute for Energy Problems of Chemical Physics , Laboratory of ion and molecular physics, Russian Academy of Sciences , Moscow , Russia.
Alexey S
AS
Kononikhin
b Moscow Institute of Physics and Technology , Laboratory of ion and molecular physics , Moscow , Russia.|c V. I. Kulakov Research Center for Obstetrics, Gynecology and Perinatology , Laboratory of proteomics and metabolomics, Ministry of Healthcare of the Russian Federation , Moscow , Russia.|d V.L. Talrose Institute for Energy Problems of Chemical Physics , Laboratory of ion and molecular physics, Russian Academy of Sciences , Moscow , Russia.
Natalia L
NL
Starodubtseva
a Institute of Biomedical Problems - Russian Federation State Scientific Research Center, Laboratory of proteomics , Russian Academy of Sciences , Moscow , Russia.
Lyudmila Kh
LK
Pastushkova
a Institute of Biomedical Problems - Russian Federation State Scientific Research Center, Laboratory of proteomics , Russian Academy of Sciences , Moscow , Russia.
Daria N
DN
Kashirina
e Emanuel Institute for Biochemical Physics , Russian Academy of Sciences , Moscow , Russia.
Kristina Yu
KY
Fedorchenko
a Institute of Biomedical Problems - Russian Federation State Scientific Research Center, Laboratory of proteomics , Russian Academy of Sciences , Moscow , Russia.
Alexander G
AG
Brhozovsky
b Moscow Institute of Physics and Technology , Laboratory of ion and molecular physics , Moscow , Russia.|c V. I. Kulakov Research Center for Obstetrics, Gynecology and Perinatology , Laboratory of proteomics and metabolomics, Ministry of Healthcare of the Russian Federation , Moscow , Russia.|d V.L. Talrose Institute for Energy Problems of Chemical Physics , Laboratory of ion and molecular physics, Russian Academy of Sciences , Moscow , Russia.
Igor A
IA
Popov
a Institute of Biomedical Problems - Russian Federation State Scientific Research Center, Laboratory of proteomics , Russian Academy of Sciences , Moscow , Russia.
Irina M
IM
Larina
d V.L. Talrose Institute for Energy Problems of Chemical Physics , Laboratory of ion and molecular physics, Russian Academy of Sciences , Moscow , Russia.|e Emanuel Institute for Biochemical Physics , Russian Academy of Sciences , Moscow , Russia.|f Skolkovo Institute of Science and Technology, Space Cluster , Skolkovo , Russia.
Evgeny N
EN
Nikolaev
D006801:Humans; D020543:Proteome / Q000235:genetics*; D040901:Proteomics; D013026:Space Flight; D014893:Weightlessness / Q000009:adverse effects*
D020543:Proteome
MARS 500; Spaceflight; bed rest study; dry immersion; extreme conditions; human proteome; microgravity; proteomics; spaceflight simulation