MicroRNA regulation of autophagy in cardiovascular disease.
Autophagy, a form of lysosomal degradation capable of eliminating dysfunctional proteins and organelles, is a cellular process associated with homeostasis. Autophagy functions in cell survival by breaking down proteins and organelles and recycling them to meet metabolic demands. However, aberrant up regulation of autophagy can function as an alternative to apoptosis. The duality of autophagy, and its regulation over cell survival/death, intimately links it with human disease. Non-coding RNAs regulate mRNA levels and elicit diverse effects on mammalian protein expression. The most studied non-coding RNAs to-date are microRNAs (miRNA). MicroRNAs function in post-transcriptional regulation, causing profound changes in protein levels, and affect many biological processes and diseases. The role and regulation of autophagy, whether it is beneficial or harmful, is a controversial topic in cardiovascular disease. A number of recent studies have identified miRNAs that target autophagy-related proteins and influence the development, progression, or treatment of cardiovascular disease. Understanding the mechanisms by which these miRNAs work can provide promising insight and potential progress towards the development of therapeutic treatments in cardiovascular disease.
Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, Ohio 43210, USA.
Matthew A
MA
Sermersheim
Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, Ohio 43210, USA.
Ki Ho
KH
Park
Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, Ohio 43210, USA.
Kristyn
K
Gumpper
Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, Ohio 43210, USA.
T M Ayodele
TM
Adesanya
Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, Ohio 43210, USA.
Kuncheng
K
Song
Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, Ohio 43210, USA.
Tao
T
Tan
Department of Pharmacology, The Penn State Hershey Cancer Institute, The Pennsylvania State University, College of Medicine and Milton S. Hershey Medical Center, 500 University Drive, Hershey, PA 17033, USA.
Xingcong
X
Ren
Department of Pharmacology, The Penn State Hershey Cancer Institute, The Pennsylvania State University, College of Medicine and Milton S. Hershey Medical Center, 500 University Drive, Hershey, PA 17033, USA.
Jin-Ming
JM
Yang
Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, Ohio 43210, USA, Hua.Zhu@osumc.edu.
Hua
H
Zhu
D000818:Animals; D001343:Autophagy / Q000235:genetics* / Q000502:physiology; D002318:Cardiovascular Diseases / Q000235:genetics* / Q000473:pathology* / Q000503:physiopathology; D058065:Diabetic Cardiomyopathies / Q000235:genetics / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D008955:Models, Cardiovascular; D017202:Myocardial Ischemia / Q000235:genetics / Q000473:pathology / Q000503:physiopathology; D020257:Ventricular Remodeling / Q000235:genetics / Q000502:physiology
D035683:MicroRNAs