Cyclophosphamide-associated enteritis: A rare association with severe enteritis.
Cyclophosphamide is a potent cytotoxic agent used in many clinical settings. The main risks of cyclophosphamide therapy include hematological disorders, infertility, hemorrhagic cystitis and malignancies. Gastrointestinal side effects reported to date are often non-specific and not severe. We present the first case of a fatal small bowel enteritis and pan-colitis which appears to be associated with cyclophosphamide. We aim to raise the readers' awareness of this significant adverse event to facilitate clinical suspicion and early recognition in potential future cases.
Linda S Yang, Karla Cameron, Tim Papaluca, Chamara Basnayake, Barbara Demediuk, Sally J Bell, Alexander J Thompson, Department of Gastroenterology, St. Vincent's Hospital, Fitzroy, Victoria 3065, Australia.
Linda S
LS
Yang
Linda S Yang, Karla Cameron, Tim Papaluca, Chamara Basnayake, Barbara Demediuk, Sally J Bell, Alexander J Thompson, Department of Gastroenterology, St. Vincent's Hospital, Fitzroy, Victoria 3065, Australia.
Karla
K
Cameron
Linda S Yang, Karla Cameron, Tim Papaluca, Chamara Basnayake, Barbara Demediuk, Sally J Bell, Alexander J Thompson, Department of Gastroenterology, St. Vincent's Hospital, Fitzroy, Victoria 3065, Australia.
Tim
T
Papaluca
Linda S Yang, Karla Cameron, Tim Papaluca, Chamara Basnayake, Barbara Demediuk, Sally J Bell, Alexander J Thompson, Department of Gastroenterology, St. Vincent's Hospital, Fitzroy, Victoria 3065, Australia.
Chamara
C
Basnayake
Linda S Yang, Karla Cameron, Tim Papaluca, Chamara Basnayake, Barbara Demediuk, Sally J Bell, Alexander J Thompson, Department of Gastroenterology, St. Vincent's Hospital, Fitzroy, Victoria 3065, Australia.
Louise
L
Jackett
Linda S Yang, Karla Cameron, Tim Papaluca, Chamara Basnayake, Barbara Demediuk, Sally J Bell, Alexander J Thompson, Department of Gastroenterology, St. Vincent's Hospital, Fitzroy, Victoria 3065, Australia.
Penelope
P
McKelvie
Linda S Yang, Karla Cameron, Tim Papaluca, Chamara Basnayake, Barbara Demediuk, Sally J Bell, Alexander J Thompson, Department of Gastroenterology, St. Vincent's Hospital, Fitzroy, Victoria 3065, Australia.
David
D
Goodman
Linda S Yang, Karla Cameron, Tim Papaluca, Chamara Basnayake, Barbara Demediuk, Sally J Bell, Alexander J Thompson, Department of Gastroenterology, St. Vincent's Hospital, Fitzroy, Victoria 3065, Australia.
Barbara
B
Demediuk
Linda S Yang, Karla Cameron, Tim Papaluca, Chamara Basnayake, Barbara Demediuk, Sally J Bell, Alexander J Thompson, Department of Gastroenterology, St. Vincent's Hospital, Fitzroy, Victoria 3065, Australia.
Sally J
SJ
Bell
Linda S Yang, Karla Cameron, Tim Papaluca, Chamara Basnayake, Barbara Demediuk, Sally J Bell, Alexander J Thompson, Department of Gastroenterology, St. Vincent's Hospital, Fitzroy, Victoria 3065, Australia.
Alexander J
AJ
Thompson
D000970:Antineoplastic Agents / Q000009:adverse effects; D003520:Cyclophosphamide / Q000009:adverse effects*; D003937:Diagnosis, Differential; D004724:Endoscopy; D004751:Enteritis / Q000139:chemically induced* / Q000150:complications*; D017809:Fatal Outcome; D005921:Glomerulonephritis / Q000150:complications / Q000188:drug therapy; D006801:Humans; D007422:Intestines / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed
D000970:Antineoplastic Agents; D003520:Cyclophosphamide
Colitis; Cyclophosphamide; Enteritis; Pan-colitis; Small bowel