Prognosis of thymectomy in myasthenia gravis patients with thymus hyperplasia.
OBJECTIVE
To compare the post-thymectomy prognosis in different conditions of myasthenia gravis (MG) patients with thymus hyperplasia.


METHODS
Collecting medical record and carrying out the follow-up study of 123 myasthenia gravis patients with thymus hyperplasia who have underwent thymectomy during the period between 2003 and 2013. Dividing into different groups based on gender, age of onset, duration of disease and Myasthenia Gravis Association of America (MGFA) clinical classification to analyze different prognosis in different groups.


RESULTS
Complete stable remission (CSR) was achieved in 71 of 123 patients (59.5%). There is no gender-related difference in achieving CSR. Patients with early onset of MG (≤40 years old) or disease duration less than 12 months had significantly higher CSR rates than those with late onset of MG (>40 years old) or disease duration more than 12 months respectively, while no difference was found in remission rate between MGFA clinical classification I and MGFA II.


CONCLUSIONS
Myasthenia gravis patients with thymus hyperplasia who had thymectomy are proved to possess greater chance of achieving CSR. The onset age of disease and duration are the prognostic factors.
a Department of Neurology , Renmin Hospital of Wuhan University , Wuhan , China.
Jing
J
Yang
b Department of Neurology , Tongji Hospital , Wuhan , China.
Chanchan
C
Liu
a Department of Neurology , Renmin Hospital of Wuhan University , Wuhan , China.
Tao
T
Li
a Department of Neurology , Renmin Hospital of Wuhan University , Wuhan , China.
Chengyan
C
Li
D000293:Adolescent; D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000378:metabolism; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000150:complications* / Q000000981:diagnostic imaging / Q000601:surgery* / Q000628:therapy; D011379:Prognosis; D016016:Proportional Hazards Models; D011950:Receptors, Cholinergic / Q000276:immunology; D012189:Retrospective Studies; D013934:Thymectomy / Q000379:methods*; D013952:Thymus Hyperplasia / Q000150:complications* / Q000000981:diagnostic imaging / Q000601:surgery*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D055815:Young Adult
D001323:Autoantibodies; D016756:Immunoglobulins, Intravenous; D011950:Receptors, Cholinergic
Myasthenia gravis; complete stable remission; thymectomy; thymus hyperplasia