Fixed drug eruption by etoricoxib confirmed by patch test.
Non-steroidal, anti-inflammatory drugs, followed by antibiotics, are the main causes of fixed drug eruption. They provoke one or several round erythematous or bullous lesions that recur in the same place after taking the causative medication. A positive patch test on residual, lesional skin can replace satisfactorily oral reintroduction. We describe the case of a 74-year-old woman with numerous, rounded, erythematous lesions on the trunk and recurrent blistering on the fifth right-hand finger, which developed a few hours after taking etoricoxib. Lesional patch testing with etoricoxib was positive and reproduced the typical pattern of a fixed drug eruption upon histopathology. We emphasize the specific reactivity of the etoricoxib patch test, and the capacity to reproduce the histologic pattern of the reaction.
Complexo Hospitalar Padre Bento de Guarulhos - Guarulhos (SP), Brazil.
Aline Soares de
AS
Sousa
Hospital Universitário de Coimbra - Coimbra, Portugal.
José Carlos
JC
Cardoso
Hospital Universitário de Coimbra - Coimbra, Portugal.
Miguel Pinto
MP
Gouveia
Hospital Universitário de Coimbra - Coimbra, Portugal.
Ana Rita
AR
Gameiro
Hospital Universitário de Coimbra - Coimbra, Portugal.
Vera Barreto
VB
Teixeira
Hospital Universitário de Coimbra - Coimbra, Portugal.
Maria
M
Gonçalo
D000368:Aged; D052246:Cyclooxygenase 2 Inhibitors / Q000009:adverse effects*; D003875:Drug Eruptions / Q000209:etiology* / Q000473:pathology; D000077613:Etoricoxib; D005260:Female; D006801:Humans; D010328:Patch Tests / Q000379:methods*; D011725:Pyridines / Q000009:adverse effects*; D013450:Sulfones / Q000009:adverse effects*
D052246:Cyclooxygenase 2 Inhibitors; D011725:Pyridines; D013450:Sulfones; D000077613:Etoricoxib