Evaluation of antifungal efficacy of QMix 2in1 as a final irrigant: Anin vitrostudy.
BACKGROUND
It is known that no specific antifungal agent exists at present for irrigation of infected root canals. QMix 2in1 was investigated to determine whether they could be an alternative for sodium hypochlorite (NaOCl), chlorhexidine gluconate (CHX), and ethylenediaminetetraacetic acid (EDTA).


OBJECTIVE
The aim of this in vitro study was to evaluate and compare the antifungal efficacy of QMix 2in1, 5.25% NaOCl, 2% CHX, and 17% EDTA as a final rinse against Candida albicans (C. albicans).


METHODS
Ninety single-rooted mandibular premolar teeth were randomly divided into four experimental (n = 20) and two control (n = 5) groups. All root canals were instrumented with Mtwo rotary file system using crown-down technique to an apical size 40. Following root canal preparation, teeth were inoculated with C. albicans and incubated for 72 h. Teeth were irrigated with one of the following solutions as a final irrigant: (1) 5.25% NaOCl, (2) 2% CHX, (3) QMix 2in1, and (4) 17% EDTA. Aliquots from the samples were plated on 4% Sabouraud Agar, and colony-forming units were counted.


RESULTS
QMix 2in1, 5.25% NaOCl, and 2% CHX were equally effective (P > 0.05) and significantly superior to 17% EDTA in eradicating C. albicans (P < 0.05).


CONCLUSIONS
QMix 2in1 proved to be effective against C. albicans when used as a final rinse. According to the findings of the present study, QMix 2in1 may be recommended as an alternative final rinse solution.
Department of Endodontics, Faculty of Dentistry, Ondokuz Mayis University, 55139 Samsun, Turkey.
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E
Kalyoncuoglu
Department of Pediatric Dentistry, Faculty of Dentistry, Ondokuz Mayis University, 55139 Samsun, Turkey.
E Sen
ES
Tunc
Department of Pediatric Dentistry, Faculty of Dentistry, Ondokuz Mayis University, 55139 Samsun, Turkey.
S
S
Ozer
Department of Endodontics, Faculty of Dentistry, Ondokuz Mayis University, 55139 Samsun, Turkey.
C
C
Keskin
Department of Medical Services and Techniques, Vocational School of Health Services, Ondokuz Mayis University, 55139 Samsun, Turkey.
K
K
Bilgin
Department of Medical Microbiology, Faculty of Medicine, Ondokuz Mayis University, 55139 Samsun, Turkey.
A
A
Birinci
D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D001645:Biguanides / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects*; D002710:Chlorhexidine / Q000031:analogs & derivatives* / Q000494:pharmacology; D004202:Disinfectants / Q000494:pharmacology*; D004492:Edetic Acid / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D011108:Polymers / Q000494:pharmacology*; D011897:Random Allocation; D012388:Root Canal Irrigants / Q000494:pharmacology*; D018915:Root Canal Preparation / Q000379:methods*; D012973:Sodium Hypochlorite / Q000494:pharmacology*
D000891:Anti-Infective Agents, Local; D001645:Biguanides; D004202:Disinfectants; D011108:Polymers; C557698:QMix root canal irrigant; D012388:Root Canal Irrigants; D004492:Edetic Acid; D012973:Sodium Hypochlorite; C010882:chlorhexidine gluconate; D002710:Chlorhexidine