Progress and prospect of mesenchymal stem cell-based therapy in atherosclerosis.
Atherosclerosis is a chronic inflammatory disease of the arterial intima, occurring usually in the aged populations who are suffering from hypertension, dyslipidemia and diabetes for a long time. Research on atherosclerosis has shown that macrophage foam cell formation, inflammation, dyslipidemia and immune cells infiltration are all involved in regulating the onset and progression of atherosclerosis. Mesenchymal stem cells (MSCs) originated from different kinds of tissue are a group of cells possessing well-established self-renewal and multipotent differentiation properties as well as immunomodulatory and anti-inflammatory roles. Recent studies have displayed their dyslipidemia regulation functions. Transplantation of MSCs to atherosclerotic patients might be a new multifactorial therapeutic strategy to improve atherosclerosis. This review updates the advancement on MSCs and atherosclerosis.
Division of Cardiology, Third Affiliated Hospital at Sun Yat-sen UniversityGuangzhou 510630, Guangdong, China; Center for Clinic Immunology, Third Affiliated Hospital at Sun Yat-sen UniversityGuangzhou 4510630, Guangdong, China.
Ximei
X
Zhang
Center for Clinic Immunology, Third Affiliated Hospital at Sun Yat-sen University Guangzhou 4510630, Guangdong, China.
Feng
F
Huang
Division of Endocrinology, Third Affiliated Hospital at Sun Yat-sen University Guangzhou 510630, Guangdong, China.
Yanming
Y
Chen
Division of Cardiology, Third Affiliated Hospital at Sun Yat-sen UniversityGuangzhou 510630, Guangdong, China; Center for Clinic Immunology, Third Affiliated Hospital at Sun Yat-sen UniversityGuangzhou 4510630, Guangdong, China; Institute Integrated Traditional Chinese and Western Medicine, Sun Yat-sen UniversityGuangzhou 510630, Guangdong, China.
Xiaoxian
X
Qian
Center for Clinic Immunology, Third Affiliated Hospital at Sun Yat-sen UniversityGuangzhou 4510630, Guangdong, China; Division of Rheumatology, Penn State Milton S. Hershey Medical CenterHershey, PA 17033, USA.
Song Guo
SG
Zheng
Mesenchymal stem cells; atherosclerosis; differentiation; foam cells; macrophages; t cells