Host and clinical aspects in patients with benign migratory glossitis.
OBJECTIVE
Investigate the association of clinical, cytological and genetic characteristics with benign migratory glossitis (BMG).


METHODS
Sample consisted of 175 patients, 44 with BMG and 131 control patients. Clinical examination and DMFT index were assessed. Cytological evaluation determined cell morphology and morphometry. Genetic evaluation was performed by analysing IL6 polymorphisms by real-time PCR. Univariate and multivariate analyses were performed (p<0.05).


RESULTS
There was a higher level of anxiety, DMFT score and a prevalence of fissured tongue in BMG group. A high mean nuclear/cytoplasmic area ratio was observed in patients with BMG. There was predominance of Papanicolaou class II I BMG group. IL6 allele G rs2069843 polymorphism was associated with BMG in the dominant model. In multivariate analysis, DMFT and anxiety scale remained associated with BMG.
Universidade Positivo, Curitiba, PR, Brazil. Electronic address: scariot@yahoo.com.br.
Rafaela
R
Scariot
Universidade Federal do Paraná, Curitiba, PR, Brazil.
Thiago Beltrami Dias
TB
Batista
Pontifícia Universidade Católica do Paraná, Curitiba, PR, Brazil.
Marcia
M
Olandoski
Pontifícia Universidade Católica do Paraná, Curitiba, PR, Brazil.
Cleber Machado
CM
Souza
Pontifícia Universidade Católica do Paraná, Curitiba, PR, Brazil.
Paulo Henrique Couto
PH
Souza
Universidade Federal do Paraná, Curitiba, PR, Brazil.
Antonio Adilson Soares
AA
Lima
Pontifícia Universidade Católica do Paraná, Curitiba, PR, Brazil.
Paula Cristina
PC
Trevilatto
D000328:Adult; D000483:Alleles; D001007:Anxiety / Q000235:genetics / Q000473:pathology; D001938:Brazil / Q000453:epidemiology; D005260:Female; D020022:Genetic Predisposition to Disease; D005929:Glossitis, Benign Migratory / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology* / Q000523:psychology; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D015995:Prevalence; D012959:Socioeconomic Factors; D014063:Tongue, Fissured / Q000453:epidemiology / Q000235:genetics
C508600:IL6 protein, human; D015850:Interleukin-6
Benign migratory glossitis; Genetic polymorphism; IL-6; Pap smear