Common Themes in Cytoskeletal Remodeling by Intracellular Bacterial Effectors.
Bacterial pathogens interact with various types of tissues to promote infection. Because it controls the formation of membrane extensions, adhesive processes, or the junction integrity, the actin cytoskeleton is a key target of pathogens during infection. We will highlight common and specific functions of the actin cytoskeleton during bacterial infections, by first reviewing the mechanisms of intracellular motility of invasive Shigella, Listeria, and Rickettsia. Through the models of EPEC/EHEC, Shigella, Salmonella, and Chlamydia spp., we will illustrate various strategies of diversion of actin cytoskeletal processes used by these bacteria to colonize or breach epithelial/endothelial barriers.
Equipe Communication Intercellulaire et Infections Microbiennes, Centre de Recherche Interdisciplinaire en Biologie (CIRB), Collège de France, 75005, Paris, France. guy.tran-van-nhieu@college-de-france.fr.|Institut National de la Santé et de la Recherche Médicale U1050, 75005, Paris, France. guy.tran-van-nhieu@college-de-france.fr.|Centre National de la Recherche Scientifique UMR7241, 75005, Paris, France. guy.tran-van-nhieu@college-de-france.fr.|MEMOLIFE Laboratory of Excellence and Paris Science Lettre, 75005, Paris, France. guy.tran-van-nhieu@college-de-france.fr.
Guy Tran
GT
Van Nhieu
Equipe Communication Intercellulaire et Infections Microbiennes, Centre de Recherche Interdisciplinaire en Biologie (CIRB), Collège de France, 75005, Paris, France.|Institut National de la Santé et de la Recherche Médicale U1050, 75005, Paris, France.|Centre National de la Recherche Scientifique UMR7241, 75005, Paris, France.|MEMOLIFE Laboratory of Excellence and Paris Science Lettre, 75005, Paris, France.
Stéphane
S
Romero
D008841:Actin Cytoskeleton / Q000502:physiology*; D000818:Animals; D001424:Bacterial Infections / Q000503:physiopathology*; D054884:Host-Pathogen Interactions; D006801:Humans; D008840:Microfilament Proteins / Q000502:physiology; D010716:Phosphatidylinositols / Q000502:physiology; D011505:Protein-Tyrosine Kinases / Q000502:physiology; D011554:Pseudopodia / Q000502:physiology
D008840:Microfilament Proteins; D010716:Phosphatidylinositols; D011505:Protein-Tyrosine Kinases
Actin-based motility; Chlamydia; Cytoskeleton; EPEC/EHEC; Invasion; Listeria; Rickettsia; Salmonella; Shigella; Type III effectors