Neuroglobin, a Factor Playing for Nerve Cell Survival.
Cell death represents the final outcome of several pathological conditions of the central nervous system and available evidence suggests that in both acute injuries and neurodegenerative diseases it is often associated with mitochondrial dysfunction. Thus, the possibility to prevent mitochondrial events involved in cell death might represent efficient tools to limit neuronal damage. In recent years, increased attention has been paid to the endogenous protein neuroglobin, since accumulating evidence showed that its high expression was associated with preserved mitochondrial function and to an increased survival of nerve cells in vitro and in vivo in a variety of experimental models of cell insult. The biological and structural features of neuroglobin and the mitochondria-related mechanisms of neuroglobin-induced neuroprotection will be here briefly discussed. In this respect, the inhibition of the intrinsic pathway of apoptosis emerges as a key neuroprotective effect induced by the protein. These findings could open the possibility to develop efficient neuroglobin-mediated therapeutic strategies aimed at minimizing the neuronal cell death occurring in impacting neurological pathologies like stroke and neurodegenerative diseases.
Department of Neuroscience, University of Padova, Padova 35122, Italy. diego.guidolin@unipd.it.
Diego
D
Guidolin
Department of Neuroscience, University of Padova, Padova 35122, Italy. cinzia.tortorella@unipd.it.
Cinzia
C
Tortorella
Department of Pharmacy and Center of Excellence for Biomedical Research, University of Genova, Genova 16126, Italy. marcoli@pharmatox.unige.it.
Manuela
M
Marcoli
Department of Pharmacy and Center of Excellence for Biomedical Research, University of Genova, Genova 16126, Italy. maura@pharmatox.unige.it.
Guido
G
Maura
Department of Biomedical Sciences, University of Modena and Reggio Emilia, Modena 41121, Italy. luigi.agnati@gmail.com.|Department of Neuroscience, Karolinska Institutet, Stockholm 17177, Sweden. luigi.agnati@gmail.com.
Luigi F
LF
Agnati
D000818:Animals; D017209:Apoptosis; D002470:Cell Survival; D005914:Globins / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D009419:Nerve Tissue Proteins / Q000737:chemistry / Q000378:metabolism*; D000078787:Neuroglobin; D009474:Neurons / Q000166:cytology* / Q000378:metabolism*; D000066829:Neuroprotection
D009419:Nerve Tissue Proteins; D000078787:Neuroglobin; D005914:Globins
apoptosis; cytochrome c; mitochondria; neuroglobin; protein–protein interaction