The detection of tumor location and lymph node metastasis by aberrant NXPH1 and NXPH2 expressions in pancreatic ductal adenocarcinomas.
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease associated with a poor
prognosis and high morbidity. Early diagnosis and complete tumor removal are still the principal
factors extending life expectancy in PDAC patients. Here, the relationship of neurexophillin 1 (NXPH1) and NXPH2
expressions with clinicopathological parameters of PDAC was evaluated. Immunohistochemical
analysis of NXPH1 and NXPH2 was performed in one tissue microarray of 96 surgical specimens,
including normal pancreatic duct tissue (n = 5), PDACs at various stages of differentiation (n = 77),
and pancreatic neuroendocrine tumors (n = 14). The intensity of both NXPH1 and NXPH2 staining
was weak in only a small proportion of benign pancreatic ductal epithelial cells and was significantly
higher in most PDAC specimens than in non-neoplastic pancreatic tissue specimens. However,
no correlation of the expression of these PDAC biomarkers with tumor grades, T, N, and American Joint
Committee on Cancer (AJCC) pathologic stages was established. Contrary to our expectation, the immunohistochemical results of
NXPH1 and NXPH2 were inversely correlated with N stage in PDAC. NXPH1 and NXPH2 as PDAC
biomarkers may be used to identify patients with this tumor, help delineate appropriate surgical
margins, and identify lymph node metastasis in imaging studies.
Department of Pathology, Tungs’ Taichung MetroHarbor Hospital, Taichung 40435, Taiwan, R.O.C.
Jong-Shiaw
JS
Jin
Department of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan, R.O.C.
Wen-Chiuan
WC
Tsai
D021441:Carcinoma, Pancreatic Ductal / Q000378:metabolism* / Q000473:pathology; D006023:Glycoproteins / Q000378:metabolism*; D006801:Humans; D008207:Lymphatic Metastasis; D009479:Neuropeptides / Q000378:metabolism*; D010179:Pancreas / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000378:metabolism* / Q000473:pathology
D006023:Glycoproteins; D009479:Neuropeptides; C112162:neurexophilin
immunostaining scores; NXPH1; NXPH2; pathological stages; pancreatic carcinoma