Enhanced periodontal regeneration using collagen, stem cells or growth factors.
The regeneration of periodontal tissues still remains a challenge in periodontology. The aim of the present study was to examine the regenerative potential of a) different collagen support versus blank, b) different collagen support +/- a growth factor cocktail (GF) and c) a collagen powder versus collagen powder + periodontal ligament stem cells (PDLSCs) comparatively in a large animal model. The stem cells (SC) were isolated from extracted teeth of 15 adult miniature pigs. A total of 60 class II furcation defects were treated with the materials named above. Concluding, a histological evaluation followed. A significant increase in regeneration was observed in all treatment groups. The new attachment formation reached a maximum of 77 percent. In the control group a new attachment formation of 13 percent was observed. The study shows that all implanted materials improved periodontal regeneration, though there were no significant differences between the experimental groups. Within the limitations of this study, it can be assumed that the lack of significant differences is due to the complexity of the clinical setting.
Department of Operative Dentistry and Periodontology, University of Rostock, Rostock, Germany, tanja.basan@uni-rostock.de.
Tanja
T
Basan
Department of Operative Dentistry and Periodontology, University of Rostock, Rostock, Germany.
Daniel
D
Welly
Institute of Biosciences, Department of Microbiology, University of Rostock, Rostock, Germany.
Katja
K
Kriebel
Department of Operative Dentistry and Periodontology, University of Rostock, Rostock, Germany.
Malte
M
Scholz
Department of Operative Dentistry and Periodontology, University of Rostock, Rostock, Germany.
Anne
A
Brosemann
Department of Oral and Maxillofacial Surgery, Facial Plastic Surgery, University of Rostock, Rostock, Germany.
Jan
J
Liese
Institute for Experimental Surgery, University of Rostock, Rostock, Germany.
Brigitte
B
Vollmar
Department of Oral and Maxillofacial Surgery, Facial Plastic Surgery, University of Rostock, Rostock, Germany.
Bernhard
B
Frerich
Department of Operative Dentistry and Periodontology, University of Rostock, Rostock, Germany.
Hermann
H
Lang
D000818:Animals; D025021:Cementogenesis; D003094:Collagen; D017823:Furcation Defects / Q000628:therapy; D036341:Intercellular Signaling Peptides and Proteins / Q000494:pharmacology; D010513:Periodontal Ligament / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D011897:Random Allocation; D012038:Regeneration / Q000187:drug effects / Q000502:physiology*; D013234:Stem Cells / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D013552:Swine; D013556:Swine, Miniature; D054457:Tissue Scaffolds
D036341:Intercellular Signaling Peptides and Proteins; D003094:Collagen