Bio-inspired engineering proteinosomes with a cell-wall-like protective shell by self-assembly of a metal-chelated complex.
A cell-wall-like shell is constructed around proteinosomes by coordination complexes of tannic acid and Fe3+, which endows the engineered proteinosomes with an enhanced Young's modulus of the membrane, protease resistant ability, EDTA-mediated release of loaded DNA, and electrostatic gated encapsulated enzyme activity, as well as antioxidant capacity.
MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage, State Key Laboratory of Urban Water Resource and Environment, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin, 150001, China. liuxiaoman@hit.edu.cn xinhuang@hit.edu.cn.
Dongyue
D
Su
Xiaoman
X
Liu
Lei
L
Wang
Chao
C
Ma
Hui
H
Xie
Hao
H
Zhang
Xianghe
X
Meng
Yudong
Y
Huang
Xin
X
Huang
D000975:Antioxidants / Q000737:chemistry; D002473:Cell Wall / Q000737:chemistry / Q000378:metabolism*; D056831:Coordination Complexes / Q000737:chemistry / Q000378:metabolism*; D004247:DNA / Q000378:metabolism; D004492:Edetic Acid; D010447:Peptide Hydrolases / Q000737:chemistry* / Q000378:metabolism*; D015202:Protein Engineering; D055672:Static Electricity; D013634:Tannins / Q000737:chemistry
D000975:Antioxidants; D056831:Coordination Complexes; D013634:Tannins; D004247:DNA; D004492:Edetic Acid; D010447:Peptide Hydrolases