Effects of Quercetin on Adiponectin-Mediated Insulin Sensitivity in Polycystic Ovary Syndrome: A Randomized Placebo-Controlled Double-Blind Clinical Trial.
Polycystic ovary syndrome (PCOS) is a heterogeneous, multi-causal, and genetically complex disorder, which is related to the failure in endocrine glands. Adiponectin has been reported to be low in PCOS, even in the absence of adiposity. Quercetin reduces serum glucose, insulin, triglycerides, and cholesterol levels and increases the expression and secretion of adiponectin. The aim of this study was to determine the effect of quercetin on the adiponectin-mediated insulin sensitivity in PCOS patients. Eighty-four women with PCOS were selected and randomly assigned to 2 groups of treatment and control. The treatment group received 1 g quercetin (two 500 mg capsules) daily for 12 weeks, and the control group received placebo. In addition to anthropometric assessments, fasting serum levels of total adiponectin, high-molecular-weight (HMW) adiponectin, glucose, insulin, testosterone, LH, and SHBG were also measured at the baseline and at the end of the trial. Quercetin could slightly increase the level of adiponectin by 5.56% as compared to placebo (adjusted p-value=0.001) and HMW adiponectin by 3.9% as compared to placebo (adjusted p-value=0.017), while it reduced the level of testosterone (0.71 ng/dl in quercetin vs. 0.77 ng/dl in placebo; p<0.001) and LH (8.42 IU/l in quercetin vs. 8.68 IU/l in placebo; p=0.009). HOMA-IR levels were also significantly (p<0.001) lower in quercetin (1.84) group compared to placebo group (2.21). Oral quercetin supplementation was effective in improving the adiponectin-mediated insulin resistance and hormonal profile of women with PCOS.
Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, International Campus Tehran University of Medical Sciences, Tehran, Iran.
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Rezvan
Obstetrics and Gynecology Department, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
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Moini
Department of Biostatistics, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
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Janani
Department of Epidemiology and Biostatistics School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
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Mohammad
Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, International Campus, Tehran University of Medical Sciences, Tehran, Iran.
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Saedisomeolia
Department of Biochemistry, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
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Nourbakhsh
Department of Medical Laboratory Sciences, School of Allied Health Medicine, AJA University of Medical Sciences, Tehran, Iran.
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Gorgani-Firuzjaee
Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, International Campus, Tehran University of Medical Sciences, Tehran, Iran.
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Mazaherioun
Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, International Campus Tehran University of Medical Sciences, Tehran, Iran.
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Hosseinzadeh-Attar
D052242:Adiponectin / Q000097:blood*; D000328:Adult; D000886:Anthropometry; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D008970:Molecular Weight; D010919:Placebos; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000188:drug therapy*; D011794:Quercetin / Q000627:therapeutic use*; D055815:Young Adult
C499918:ADIPOQ protein, human; D052242:Adiponectin; D007328:Insulin; D010919:Placebos; D011794:Quercetin