Backbone resonance assignments of the F-actin binding domain of mouse αN-catenin.
α-Catenin is a filamentous actin (F-actin) binding protein that links the classical cadherin-catenin complex to the actin cytoskeleton at adherens junctions (AJs). Its C-terminal F-actin binding domain is required for regulating the dynamic interaction between AJs and the actin cytoskeleton during tissue development. Thus, obtaining the molecular details of this interaction is a crucial step towards understanding how α-catenin plays critical roles in biological processes, such as morphogenesis, cell polarity, wound healing and tissue maintenance. Here we report the backbone atom (1HN,15N,13Cα,13Cβand13C') resonance assignments of the C-terminal F-actin binding domain of αN-catenin.
Princess Margaret Cancer Centre, University Health Network and Department of Medical Biophysics, University of Toronto, 101 College Street, Toronto, ON, M5G 1L7, Canada.
Tadateru
T
Nishikawa
Princess Margaret Cancer Centre, University Health Network and Department of Medical Biophysics, University of Toronto, 101 College Street, Toronto, ON, M5G 1L7, Canada.
Noboru
N
Ishiyama
Princess Margaret Cancer Centre, University Health Network and Department of Medical Biophysics, University of Toronto, 101 College Street, Toronto, ON, M5G 1L7, Canada.|Department of Biochemistry, School of Medicine, Vanderbilt University, 2215 Garland Ave., 607 Light Hall, Nashville, TN, 37232-0146, USA.
Feng
F
Wang
Princess Margaret Cancer Centre, University Health Network and Department of Medical Biophysics, University of Toronto, 101 College Street, Toronto, ON, M5G 1L7, Canada. mikura@uhnres.utoronto.ca.
Mitsuhiko
0000-0002-9524-1303
M
Ikura
D000199:Actins / Q000378:metabolism*; D000818:Animals; D051379:Mice; D019906:Nuclear Magnetic Resonance, Biomolecular; D000072417:Protein Domains; D051178:alpha Catenin / Q000737:chemistry* / Q000378:metabolism*
D000199:Actins; D051178:alpha Catenin
Cell junction; F-actin; Mechanosensor; α-Catenin