In Vivo Neural Recording and Electrochemical Performance of Microelectrode Arrays Modified by Rough-Surfaced AuPt Alloy Nanoparticles with Nanoporosity.
In order to reduce the impedance and improve in vivo neural recording performance of our developed Michigan type silicon electrodes, rough-surfaced AuPt alloy nanoparticles with nanoporosity were deposited on gold microelectrode sites through electro-co-deposition of Au-Pt-Cu alloy nanoparticles, followed by chemical dealloying Cu. The AuPt alloy nanoparticles modified gold microelectrode sites were characterized by scanning electron microscopy (SEM), electrochemical impedance spectroscopy (EIS), cyclic voltammetry (CV) and in vivo neural recording experiment. The SEM images showed that the prepared AuPt alloy nanoparticles exhibited cauliflower-like shapes and possessed very rough surfaces with many different sizes of pores. Average impedance of rough-surfaced AuPt alloy nanoparticles modified sites was 0.23 MΩ at 1 kHz, which was only 4.7% of that of bare gold microelectrode sites (4.9 MΩ), and corresponding in vitro background noise in the range of 1 Hz to 7500 Hz decreased to 7.5 μ V rms from 34.1 μ V rms at bare gold microelectrode sites. Spontaneous spike signal recording was used to evaluate in vivo neural recording performance of modified microelectrode sites, and results showed that rough-surfaced AuPt alloy nanoparticles modified microelectrode sites exhibited higher average spike signal-to-noise ratio (SNR) of 4.8 in lateral globus pallidus (GPe) due to lower background noise compared to control microelectrodes. Electro-co-deposition of Au-Pt-Cu alloy nanoparticles combined with chemical dealloying Cu was a convenient way for increasing the effective surface area of microelectrode sites, which could reduce electrode impedance and improve the quality of in vivo spike signal recording.
Key Laboratory of Biomedical Information Engineering of the Ministry of Education, Institute of Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China. zhaozongya2010@stu.xjtu.edu.cn.|National Engineering Research Center of Health Care and Medical Devices, Xi'an Jiaotong University Branch, Xi'an 710049, China. zhaozongya2010@stu.xjtu.edu.cn.
Zongya
Z
Zhao
Key Laboratory of Biomedical Information Engineering of the Ministry of Education, Institute of Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China. gongruxue@stu.xjtu.edu.cn.|National Engineering Research Center of Health Care and Medical Devices, Xi'an Jiaotong University Branch, Xi'an 710049, China. gongruxue@stu.xjtu.edu.cn.
Ruxue
R
Gong
Key Laboratory of Biomedical Information Engineering of the Ministry of Education, Institute of Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China. ylzhengliang@stu.xjtu.edu.cn.|National Engineering Research Center of Health Care and Medical Devices, Xi'an Jiaotong University Branch, Xi'an 710049, China. ylzhengliang@stu.xjtu.edu.cn.
Liang
L
Zheng
Key Laboratory of Biomedical Information Engineering of the Ministry of Education, Institute of Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China. juewang@mail.xjtu.edu.cn.|National Engineering Research Center of Health Care and Medical Devices, Xi'an Jiaotong University Branch, Xi'an 710049, China. juewang@mail.xjtu.edu.cn.
Jue
J
Wang
D000497:Alloys / Q000737:chemistry*; D058266:Dielectric Spectroscopy; D004563:Electrochemistry / Q000379:methods*; D004567:Electrodes, Implanted; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D008839:Microelectrodes; D008855:Microscopy, Electron, Scanning; D059629:Signal-To-Noise Ratio
D000497:Alloys
electro-co-deposition; in vivo neural recording; microelectrode arrays; rough-surfaced AuPt alloy nanoparticles