Combined Administration ofMelissa officinalisandBoswellia serrataExtracts in an Animal Model of Memory.
BACKGROUND
Boswellia serrataandMelissa officinalisis traditionally used for its memory enhancing effects.


OBJECTIVE
In this study, we evaluated the protective effects of combined form of these extracts on memory improvement of scopolamine treated rats by the Morris water maze method.


METHODS
Two groups (group 1 and 2) of animals were pretreated with combined extracts ofB. serrataandM. officinalis(200, 400 mg/Kg body weight) for four weeks and then, 30 minutes before starting the experiment scopolamine was injected (0.1 mg/kg body weight) intraperitoneally to pretreated animals. The control group was the animals that were injected by scopolamine and pre treated with distilled water (group 3). The normal group was treated with distilled water alone (group 4).


RESULTS
For time spent and distance, there was no substantial difference between groups 1, 2 and 4, while they had statistical difference with group 3 (P = 0.001). The spatial memory evaluation showed no significant difference between treated groups and normal group.


CONCLUSIONS
Therefore, the combination of the two extracts had the ability to improve memory as its traditional use.
Microbiology Department, Medicinal Plant Research Center of Barij Essence, Kashan, IR Iran.
Mohaddese
M
Mahboubi
Research Center for Biochemistry and Nutrition in Metabolic disorders, Kashan University of Medical Sciences, Kashan, IR Iran.
Mohsen
M
Taghizadeh
Physiology Research Center, Kashan University of Medical Sciences, Kashan, IR Iran.
Sayyed Alireza
SA
Talaei
Physiology Research Center, Kashan University of Medical Sciences, Kashan, IR Iran.
Sayyed Mehdi
SM
Takht Firozeh
Physiology Research Center, Kashan University of Medical Sciences, Kashan, IR Iran.
Ali Akbar
AA
Rashidi
Physiology Research Center, Kashan University of Medical Sciences, Kashan, IR Iran.
Omid Reza
OR
Tamtaji
Boswellia serrata; Melissa officinalis; Rat; Scopolamine; Spatial Memory