Pharmacological analysis of SGLT2 inhibitor (tofogliflozin) using in vivo glucose clamp and titration protocols in rats and cynomolgus monkeys.
Masanori
M
Fukazawa
Takumi
T
Nagata
Masayuki
M
Suzuki
Yoshiyuki
Y
Suzuki
Yoshiki
Y
Kawabe
D000818:Animals; D001559:Benzhydryl Compounds / Q000494:pharmacology*; D005947:Glucose / Q000378:metabolism; D015309:Glucose Clamp Technique; D005960:Glucosides / Q000494:pharmacology*; D006801:Humans; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008252:Macaca fascicularis; D051381:Rats
D001559:Benzhydryl Compounds; D005960:Glucosides; D007004:Hypoglycemic Agents; D005947:Glucose; C575086:6-((4-ethylphenyl)methyl)-3',4',5',6'-tetrahydro-6'-(hydroxymethyl)spiro(isobenzofuran-1(3H),2'-(2H)pyran)-3',4',5'-triol