Isolated Nonsyndromic Intraneural Neuroma of the Eyelid Skin.
A 56-year-old man developed a 2 × 2 mm, yellow-orange painless, smooth-surfaced nodule in the middle third of his left upper eyelid. Microscopic evaluation disclosed a spindle cell tumor that was well circumscribed by a perineurium. The tumor cells manifested wavy, bland nuclei displaying comma-shaped and pointed ends. These cells were uniformly S100 positive. Immunohistochemical analysis further revealed an even dispersion of numerous dot-like neurofilaments diagnostic of an isolated intraneural neuroma. A neuroma differs from a schwannoma which fails to exhibit neurofilaments except in a peripherally located compressed nerve of origin. Simple excision is recommended.
*David G. Cogan Laboratory of Ophthalmic Pathology, Massachusetts Eye & Ear Infirmary; †Department of Ophthalmology, Harvard Medical School; and ‡Ophthalmic Plastic Surgery, Massachusetts Eye & Ear Infirmary, Boston, Massachusetts, U.S.A.
Frederick A
FA
Jakobiec
Alia
A
Rashid
Michael K
MK
Yoon
D001706:Biopsy; D003937:Diagnosis, Differential; D005142:Eyelid Neoplasms / Q000175:diagnosis*; D005143:Eyelids / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009463:Neuroma / Q000175:diagnosis*; D012867:Skin / Q000000981:diagnostic imaging*; D012878:Skin Neoplasms / Q000175:diagnosis*