Roles of leptin and ghrelin in the regulation of the phenotype and cytokine production by NK cells from peripheral blood.
Both leptin and ghrelin used separately at the concentrations corresponding to trimesters II-III of pregnancy increase the number of CD56brightNK cells in mononuclear cell suspension; their combination also enhances the L-selectin expression on the surface of these cells in the culture. These hormones do not affect the production of TGF-β1, IL-17А, or IFN-γ by NK cells, and they inhibit the production of IL-10. Leptin decreses the IL-4 production by NKp46+cells, but the presence of ghrelin abrogates this effect.
Institute of Ecology and Genetics of Microorganisms, Ural Branch, Russian Academy of Sciences, Perm, 614081, Russia. shirshev@iegm.ru.
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Shirshev
Institute of Ecology and Genetics of Microorganisms, Ural Branch, Russian Academy of Sciences, Perm, 614081, Russia.
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Nekrasova
Institute of Ecology and Genetics of Microorganisms, Ural Branch, Russian Academy of Sciences, Perm, 614081, Russia.
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Orlova
Institute of Ecology and Genetics of Microorganisms, Ural Branch, Russian Academy of Sciences, Perm, 614081, Russia.
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Gorbunova
D000328:Adult; D049109:Cell Proliferation / Q000502:physiology; D002478:Cells, Cultured; D016207:Cytokines / Q000378:metabolism*; D005260:Female; D005786:Gene Expression Regulation / Q000276:immunology; D054439:Ghrelin / Q000276:immunology*; D006801:Humans; D007694:Killer Cells, Natural / Q000166:cytology* / Q000378:metabolism*; D020738:Leptin / Q000276:immunology*; D007963:Leukocytes, Mononuclear / Q000166:cytology / Q000276:immunology
D016207:Cytokines; D054439:Ghrelin; D020738:Leptin