Intraperitoneal Fat through GRP78: A Risk Factor for Endometrial Cancer.
Introduction.The identification of biological markers that indicate an increased risk for the development or recurrence of endometrial cancer (EC) in obese women might be useful for decreasing EC mortality and morbidity. Glucose-regulated protein 78 (GRP78) is a major protein of the endoplasmic reticulum expressed in all normal cells. Overexpression of GRP78 has been reported to be a tumoral biomarker. Increased detection of GRP78 is positively correlated with the tumoral stage and prognosis. This study aimed to identify a correlation between intraperitoneal fat, plasma GRP78 levels, and EC.Materials and Methods.Two groups of patients were included in the study: group I, 44 patients diagnosed with EC, and group II, 44 patients without gynecological pathology or inflammatory disorders. Visceral fat was determined by ultrasound and plasma GRP78 levels were measured.Results. Plasma GRP78 levels were significantly higher in patients with EC compared to the control group. Intraperitoneal fat was in a positive linear correlation with the plasma GRP78 level (p< 0.0001).Conclusion.The measurement of the GRP78 level associated with the determination of intraperitoneal fat can be a useful predictor for EC.
2nd Department of Obstetrics and Gynecology, "Iuliu Hațieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Răzvan
R
Ciortea
Department of Obstetrics and Gynecology, University of Medicine and Pharmacy of Craiova, Craiova, Romania.
Costin
C
Berceanu
2nd Department of Obstetrics and Gynecology, "Iuliu Hațieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Andrei Mihai
0000-0001-7666-6261
AM
Măluţan
2nd Department of Obstetrics and Gynecology, "Iuliu Hațieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Radu
R
Mocan
2nd Department of Obstetrics and Gynecology, "Iuliu Hațieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Cristian
C
Iuhas
2nd Department of Obstetrics and Gynecology, "Iuliu Hațieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Carmen Elena
0000-0002-6596-5386
CE
Bucuri
2nd Department of Obstetrics and Gynecology, "Iuliu Hațieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Maria Patricia
MP
Rada
2nd Department of Obstetrics and Gynecology, "Iuliu Hațieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Dan
D
Mihu
D050154:Adiposity; D000368:Aged; D016889:Endometrial Neoplasms / Q000378:metabolism*; D000091342:Endoplasmic Reticulum Chaperone BiP; D005260:Female; D006360:Heat-Shock Proteins / Q000378:metabolism*; D006801:Humans; D016014:Linear Models; D010537:Peritoneum / Q000378:metabolism*; D012307:Risk Factors
D000091342:Endoplasmic Reticulum Chaperone BiP; C000717247:HSPA5 protein, human; D006360:Heat-Shock Proteins