Anti-Yo positive paraneoplastic cerebellar degeneration in the setting of cholangiocarcinoma.
Paraneoplastic neurological syndromes are a rare complication of malignancy. Subacute cerebellar ataxia, or paraneoplastic cerebellar degeneration, usually presents in women with a subcate onset of gait instability, followed by progressive limb and trunk ataxia, dysarthria, diplopia, and dysphagia that occurs in the setting of, or precedes the diagnosis of, a gynecologic or breast malignancy and clinically stabilizes within six months. The most common autoantibody associated with PCD is purkinje cell cytoplasmic antibody type 1, also known as anti-Yo. Here we describe the first reported case of a man with anti-Yo positive paraneoplastic cerebellar degeneration in the setting of occult cholangiocarcinoma.
University of Minnesota, Department of Neurology, 495 Delaware St. SE MMC 295, Minneapolis, MN 55455, United States. Electronic address: abruhn@umn.edu.
Aubree
A
Bruhnding
University of Minnesota, Medical School, 495 Delaware St. SE MMC 295, Minneapolis, MN 55455, United States. Electronic address: Notch010@d.umn.edu.
Derek
D
Notch
Minneapolis Veterans Affairs Health Care System, University of Minnesota, Department of Internal Medicine, 1 Veterans Dr, Minneapolis, MN 55417, United States. Electronic address: Albertine.beard@va.gov.
Albertine
A
Beard
D000368:Aged; D001650:Bile Duct Neoplasms / Q000175:diagnosis*; D018281:Cholangiocarcinoma / Q000175:diagnosis*; D006801:Humans; D008297:Male; D020362:Paraneoplastic Cerebellar Degeneration / Q000175:diagnosis*
Anti-Yo; Anti-purkinje cytoplasmic antibody; Cholangiocarcinmoa; Paraneoplastic cerebellar degeneration