Two Cases of Acute Disseminated Encephalomyelitis Following Vaccination Against Human Papilloma Virus.
We herein present two cases of acute disseminated encephalomyelitis (ADEM) following vaccination against human papilloma virus (HPV). Case 1 experienced diplopia and developed an unstable gait 14 days after a second vaccination of Cervarix. Brain magnetic resonance imaging (MRI) showed an isolated small, demyelinating lesion in the pontine tegmentum. Case 2 experienced a fever and limb dysesthesia 16 days after a second vaccination of Gardasil. Brain MRI revealed hyperintense lesion in the pons with slight edema on a T2-weighted image. Both cases resolved completely. It is important to accumulate further data on confirmed cases of ADEM temporally associated with HPV vaccination.
Division of Neurology, Kobe University Graduate School of Medicine, Japan.
Kenji
K
Sekiguchi
Naoko
N
Yasui
Hisatomo
H
Kowa
Fumio
F
Kanda
Tatsushi
T
Toda
D000293:Adolescent; D003937:Diagnosis, Differential; D004673:Encephalomyelitis, Acute Disseminated / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000209:etiology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D027383:Papillomaviridae / Q000276:immunology*; D053918:Papillomavirus Vaccines / Q000009:adverse effects*; D014611:Vaccination / Q000009:adverse effects
D053918:Papillomavirus Vaccines; C510352:human papillomavirus vaccine, L1 type 16, 18