Metabolic Syndrome Increases the Risk for Knee Osteoarthritis: A Meta-Analysis.
Background. Studies revealed that metabolic factors might contribute substantially to osteoarthritis (OA) pathogenesis. There has been an increasing interest to understand the relationship between knee OA and the metabolic syndrome (MetS). The purpose of this study was to explore the association between metabolic syndrome and knee osteoarthritis using meta-analysis.Methods. Databases, including PUBMED, EMBASE, and the Cochrane Library, were searched to get relevant studies. Data were extracted separately by two authors and pooled odds ratio (OR) with 95% confidence interval (CI) was calculated.Results. The meta-analysis was finished with 8 studies with a total of 3202 cases and 20968 controls finally retrieved from the database search. The crude pooled OR is 2.24 (95% CI = 1.38-3.64). Although there was significant heterogeneity among these studies, which was largely accounted for by a single study, the increase in risk was still significant after exclusion of that study. The pooled adjusted OR remained significant with pooled adjusted OR 1.05 (95% CI = 1.03-1.07,p< 0.00001). No publication bias was found in the present meta-analysis.Conclusions. The synthesis of available evidence supports that metabolic syndrome increases the risk for knee osteoarthritis, even after adjustment for many risk factors.
The First Clinical College, Jinan University and Department of Orthopedics, The First Affiliated Hospital, Jinan University, Guangzhou 510630, China.
Huajun
H
Wang
The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China.
Yanmei
Y
Cheng
Department of Orthopedics, The Third Hospital of Hebei Medical University, Shijiazhuang 050051, China.
Decheng
D
Shao
The First Clinical College, Jinan University and Department of Orthopedics, The First Affiliated Hospital, Jinan University, Guangzhou 510630, China.
Junyuan
J
Chen
The First Clinical College, Jinan University and Department of Orthopedics, The First Affiliated Hospital, Jinan University, Guangzhou 510630, China.
Yuan
Y
Sang
The First Clinical College, Jinan University and Department of Orthopedics, The First Affiliated Hospital, Jinan University, Guangzhou 510630, China.
Tao
T
Gui
The First Clinical College, Jinan University and Department of Orthopedics, The First Affiliated Hospital, Jinan University, Guangzhou 510630, China.
Simin
S
Luo
The First Clinical College, Jinan University and Department of Orthopedics, The First Affiliated Hospital, Jinan University, Guangzhou 510630, China.
Jieruo
J
Li
Department of Orthopedics, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China.
Chao
C
Chen
Department of Orthopedics, Guangzhou Orthopedic Hospital, Guangzhou 510045, China.
Yongguang
Y
Ye
Department of Orthopedics, Xingtai People's Hospital, Xingtai, Hebei 054031, China.
Yong
Y
Yang
Department of Orthopedics, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China.
Yikai
Y
Li
The First Clinical College, Jinan University and Department of Orthopedics, The First Affiliated Hospital, Jinan University, Guangzhou 510630, China.
Zhengang
0000-0002-5954-9618
Z
Zha