Recurrent transient global amnesia as presenting symptoms of CADASIL.
Despite transient global amnesia is considered unusual in Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) and causal relation is still unclear, this report suggests to consider CADASIL in those patients with recurrent transient global amnesia, especially when MRI shows multifocal hyperintensities affecting the cerebral white matter or when it is followed by cognitive decline.
Division of Neurology and Neurorehabilitation San Giuseppe Hospital IRCCS Istituto Auxologico Italiano Piancavallo VB Italy.
Luca
L
Pradotto
Neurologic Division 1 Department of Neuroscience and Mental Health AOU Città della Salute e della Scienza di Torino Turin Italy.
Laura
L
Orsi
Laboratory of Molecular Biology IRCCS Istituto Auxologico Italiano Milan Italy.
Monica
M
Mencarelli
Department of Neuroscience University of Turin Turin Italy.
Marcella
M
Caglio
Surgical Dermatology Department of Oncology AOU Città della Salute e della Scienza di Torino Turin Italy.
Danilo
D
Lauro
Division of Neurology and Neurorehabilitation San Giuseppe Hospital IRCCS Istituto Auxologico Italiano Piancavallo VB Italy.
Alessandra
A
Milesi
Laboratory of Molecular Biology IRCCS Istituto Auxologico Italiano Milan Italy.
Anna
A
Di Blasio
Division of Neurology and Neurorehabilitation San Giuseppe HospitalI RCCS Istituto Auxologico Italiano Piancavallo VB Italy; Department of Neuroscience University of Turin Turin Italy.
Alessandro
A
Mauro
CADASIL; NOTCH3 gene mutation; cognitive impairment; dementia; leukoaraiosis; microbleeds; transient global amnesia