A Meta-analysis of the association between different genotypes (G11778A,T14484CandG3460A) of Leber hereditary optic neuropathy and visual prognosis.
OBJECTIVE
To analyze the influences of different genotypes (G11778A,T14484CandG3460A) of Leber hereditary optic neuropathy (LHON) on visual prognosis.


METHODS
After a systematic literature search, all relevant studies evaluating the association between the three primary mutations of LHON and visual prognosis were included. All statistical tests were calculated with Revman 5.2 and STATA 12.0.


RESULTS
Ten independent studies were included finally. A significant association between the three primary mutations and prognostic vision over 0.3 were found inG11778AversusT14484C[odds ratio (OR)=0.10, 95% confidence interval (CI)=0.05-0.17,P<0.001],G11778AversusG3460A(OR=0.18, 95%CI=0.09-0.37,P<0.001) andT14484CversusG3460A(OR=2.45, 95%CI=1.10-5.48,P<0.05). In addition, obtained by pairwise comparison, the vision during onset, age of onset and sex ratio of these three kinds of patients, have no statistical significance (P>0.05).


CONCLUSIONS
From pairwise comparison, we conclude that these three different genotypes of LHON are related to patients' visual prognosis. TheT14484Cpatients might have a best prognostic vision,G3460Asecond, andG11778Aworst. And there is little relation between the three different genotypes and patients' vision, age of onset and sex ratio.
Department of Ophthalmology, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China.
Dong-Yu
DY
Guo
Department of Ophthalmology, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China.
Xia-Wei
XW
Wang
Department of Ophthalmology, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China.
Nan
N
Hong
Department of Ophthalmology, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China.
Yang-Shun
YS
Gu
G11778A; G3460A; Leber hereditary optic neuropathy; Meta-analysis; T14484C; visual acuity