Acute meningitis of piglets and mice caused by co-infected with Streptococcus suis and Aerococcus viridans.
The two opportunistic pathogens, Streptococcus suis (S. suis) and Aerococcus. viridans (A. viridans) were isolated from the brains of piglets suffered bacterial meningitis in a farm of China. The murine model has been established to evaluate the pathogenicity and symbiotic relationship of S. suis and A. viridans simultaneously infection. Our results demonstrated the ability of new serotype S. suis to cause the classical bacterial meningitis and death were greatly enhanced during co-infection with A. viridans in mice at a proportion. We also examined the distribution and titer of bacteria coinfection in organs, the titer of S. suis appeared a significant trend for an increase in the lung meanwhile the concentration titer of A. viridans maintain a low level. This is the first reported the A. viridans and S. suis coinfection cause the bacterial meningitis outbroke in the piglets and mice. Moreover, further investigation of the pathogenesis of A. viridans and S. suis is urgently needed in swine industry.
College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China; OIE Reference Laboratory for Swine Streptococcosis, Nanjing 210095, China.
Zihao
Z
Pan
College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China; OIE Reference Laboratory for Swine Streptococcosis, Nanjing 210095, China.
Ye
Y
Ma
College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China.
Jiale
J
Ma
College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China; OIE Reference Laboratory for Swine Streptococcosis, Nanjing 210095, China.
Wenyang
W
Dong
College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China; OIE Reference Laboratory for Swine Streptococcosis, Nanjing 210095, China. Electronic address: yaohch@njau.edu.cn.
Huochun
H
Yao
D056570:Aerococcus / Q000302:isolation & purification / Q000472:pathogenicity*; D000818:Animals; D000829:Animals, Domestic / Q000382:microbiology; D001921:Brain / Q000382:microbiology / Q000473:pathology; D002681:China / Q000453:epidemiology; D060085:Coinfection / Q000382:microbiology* / Q000401:mortality / Q000473:pathology; D015169:Colony Count, Microbial; D004195:Disease Models, Animal; D004196:Disease Outbreaks; D016908:Gram-Positive Bacterial Infections / Q000382:microbiology* / Q000473:pathology / Q000662:veterinary; D006321:Heart / Q000382:microbiology; D007668:Kidney / Q000382:microbiology / Q000473:pathology; D007928:Lethal Dose 50; D008168:Lung / Q000382:microbiology / Q000473:pathology; D008297:Male; D008581:Meningitis / Q000453:epidemiology / Q000382:microbiology* / Q000401:mortality / Q000662:veterinary*; D051379:Mice; D008807:Mice, Inbred BALB C; D013290:Streptococcal Infections / Q000382:microbiology* / Q000473:pathology / Q000662:veterinary; D017011:Streptococcus suis / Q000302:isolation & purification / Q000472:pathogenicity*; D013552:Swine; D013553:Swine Diseases / Q000382:microbiology*; D013559:Symbiosis