Transformations of alkynes to carboxylic acids and their derivatives via C[triple bond, length as m-dash]C bond cleavage.
Alkynes are building blocks of high synthetic value and their usefulness as precursors to many chemical and biological systems is widely established. Amongst several transformations of alkynes, cleavage of the C[triple bond, length as m-dash]C bond for obtaining diverse compounds is considered to be important. This review, in particular, comprehensively assimilates the transformations of alkynes to carboxylic acids including esters, amides and nitriles resulting from the cleavage of the C[triple bond, length as m-dash]C bond either under the influence of a metal catalyst or via a metal-free approach.
Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226031, India. batra_san@yahoo.co.uk s_batra@cdri.res.in.
Shivalinga
S
Kolle
Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226031, India. batra_san@yahoo.co.uk s_batra@cdri.res.in and Academy of Scientific and Innovative Research, New Delhi 110025, India.
Sanjay
http://orcid.org/0000-0002-8980-3592
S
Batra