Scrotal Apocrine Adenocarcinoma with Pagetoid Phenomenon and Inguinal Lymph Node Metastases.
We report a case of scrotal apocrine adenocarcinoma in a 72-year-old Caucasian male which was initially presented as a reddish superficial lesion which in time became an ulcerated nodule. The initial pathological examination showed an apocrine adenocarcinoma with pagetoid phenomenon. The tumor recurred after four months and then excision biopsy showed tumor with pagetoid phenomenon which reached all the surgical margins. Three months later an ulcerated nodule in the scrotum and greatly enlarged ipsilateral inguinal lymph nodes were noticed. The final pathological examination showed multiple separated malignant foci, some with overlying pagetoid phenomenon and inguinal lymph node metastases. Immunohistochemistry showed positivity for Gross Cystic Disease Fluid Protein-15 (GCDFP-15), androgen receptors, and score 3+ for the Human Epidermal growth factor Receptor-2 (HER2). The aggressive behavior of the present tumor goes along with previous reports showing that HER2 high score cases exhibit a worse prognosis.
Department of Anatomy, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece.
Aristeidis Hristos
0000-0001-7122-4317
AH
Zibis
Department of Anatomy, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece.
Apostolos Haralampos
AH
Fyllos
Department of Histology and Embryology, National and Kapodistrian University of Athens, Medical School, Athens, Greece.
Sophia
S
Havaki
Department of Embryology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece.
Sotirios
S
Sotiriou
Department of Urology, General Hospital of Florina, Florina, Greece.
Georgios
G
Kotakidis
Department of Anatomy, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece.
Dimitrios Leonidas
DL
Arvanitis