Lipoxygenase-inhibiting lignans from Clematis mandshurica.
The EtOH extract of the roots and rhizomes of Clematis mandshurica afforded two new lignans clemomanshurinane C (1) and clemomanshurinane D (2), and three known compounds (3-5). Their structures were elucidated on the basis of spectroscopic means and hydrolysis products. All compounds displayed moderate inhibitory activity against enzyme lipoxygenase.
a School of Pharmacy and Bioengineering , Chengdu University , Chengdu 610106 , China.
Qiang
Q
Fu
a School of Pharmacy and Bioengineering , Chengdu University , Chengdu 610106 , China.
Chuang
C
Zhou
a School of Pharmacy and Bioengineering , Chengdu University , Chengdu 610106 , China.
Yu
Y
Ma
a School of Pharmacy and Bioengineering , Chengdu University , Chengdu 610106 , China.
Min
M
Yang
a School of Pharmacy and Bioengineering , Chengdu University , Chengdu 610106 , China.
Hai-Mei
HM
Yuan
a School of Pharmacy and Bioengineering , Chengdu University , Chengdu 610106 , China.
Jiang
J
Chen
b Department of Gastroenterology and Hepatology , Sichuan Provincial People's Hospital , Chengdu 610072 , China.
Pei-Xi
PX
Liu
D039324:Clematis / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D016859:Lipoxygenase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D027343:Rhizome / Q000737:chemistry
D004365:Drugs, Chinese Herbal; D017705:Lignans; D016859:Lipoxygenase Inhibitors; C000622470:clemomanshurinane C; C000622471:clemomanshurinane D
Clematis mandshurica; Ranunculaceae; lignan; lipoxygenase-inhibiting activiy