On the inherent properties of Soluplus and its application in ibuprofen solid dispersions generated by microwave-quench cooling technology.
Polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer, or Soluplus®, is a relatively new copolymer and a promising carrier of amorphous solid dispersions. Knowledge on the inherent properties of Soluplus®(e.g. cloud points, critical micelle concentrations, and viscosity) in different conditions is relatively inadequate, and the application characteristics of Soluplus®-based solid dispersions made by microwave methods still need to be clarified. In the present investigation, the inherent properties of a Soluplus®carrier, including cloud points, critical micelle concentrations, and viscosity, were explored in different media and in altered conditions. Ibuprofen, a BCS class II non-steroidal anti-inflammatory drug, was selected to develop Soluplus®-based amorphous solid dispersions using the microwave-quench cooling (MQC) method. Scanning electronic microscopy (SEM), differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD), Raman spectroscopy (RS), and Fourier transform infrared spectroscopy (FT-IR) were adopted to analyze amorphous properties and molecular interactions in ibuprofen/Soluplus®amorphous solid dispersions generated by MQC. Dissolution, dissolution extension, phase solubility, equilibrium solubility, and supersaturated crystallization inhibiting experiments were performed to elucidate the effects of Soluplus®on ibuprofen in solid dispersions. This research provides valuable information on the inherent properties of Soluplus®and presents a basic understanding of Soluplus®as a carrier of amorphous solid dispersions.
a Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, College of Life Science , Jilin University , Changchun , Jilin Province , China.|b State Key Laboratory of Medicinal Chemical Biology , Nankai University , Tianjin , China.|c School of Pharmacy , Jilin Medical University , Jilin , China.
Nian-Qiu
NQ
Shi
c School of Pharmacy , Jilin Medical University , Jilin , China.
Hong-Wei
HW
Lai
d College of Life Science , Jilin University , Changchun , Jilin Province , China.
Yong
Y
Zhang
c School of Pharmacy , Jilin Medical University , Jilin , China.
Bo
B
Feng
c School of Pharmacy , Jilin Medical University , Jilin , China.
Xiao
X
Xiao
c School of Pharmacy , Jilin Medical University , Jilin , China.
Hong-Mei
HM
Zhang
a Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, College of Life Science , Jilin University , Changchun , Jilin Province , China.
Zheng-Qiang
ZQ
Li
e Department of Pharmaceutics, School of Pharmaceutical Science , Peking University , Beijing , China.
Xian-Rong
XR
Qi
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000737:chemistry; D003460:Crystallization; D004337:Drug Carriers / Q000737:chemistry*; D004339:Drug Compounding / Q000379:methods*; D007052:Ibuprofen / Q000008:administration & dosage* / Q000737:chemistry; D008823:Micelles; D008872:Microwaves; D044367:Phase Transition; D011092:Polyethylene Glycols / Q000737:chemistry*; D011145:Polyvinyls / Q000737:chemistry*; D012995:Solubility; D014783:Viscosity; D014961:X-Ray Diffraction
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004337:Drug Carriers; D008823:Micelles; D011145:Polyvinyls; C572167:polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer; D011092:Polyethylene Glycols; D007052:Ibuprofen
Soluplus®; amorphous solid dispersions; crystallization inhibition; dissolution; ibuprofen; inherent properties