MALAT1-mediated tumorigenesis.
Functional genomics studies over the past decades have unveiled that the human genome transcribes a large amount of long noncoding RNAs (lncRNAs) which have been implicated in regulation of diverse cellular functions. Dysregulation of lncRNAs are often associated with human diseases including cancer. The metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is among the most abundant and highly conserved lncRNAs. Emerging evidence has indicated that MALAT1 may have complex and extensive functions in the development and progression of cancer. In this review, we first update on the role of MALAT1 in tumorigenesis and then discuss possible molecular mechanisms that underline the MALAT1-mediated gene regulation, leading to cancer invasion and metastasis.
Department of Emergency Medicine, the First Affiliated Hospital of Guangxi Medical University. Nanning, China.
Jianghua
J
Liu
Cancer Institute, University of Mississippi Medical Center, Jackson, MS, 3Department of Cell Biology, School of Medicine, Jiangsu University, Zhenjiang, China.
Wan-Xin
WX
Peng
Department of Pharmacology and Toxicology, Cancer Institute, University of Mississippi Medical Center, Jackson, MS.
Yin-Yuan
YY
Mo
Department of Emergency Medicine, the First Affiliated Hospital of Guangxi Medical University. Nanning, China, 13878802796@163.com.
Dianzhong
D
Luo
D017398:Alternative Splicing; D063646:Carcinogenesis / Q000235:genetics* / Q000378:metabolism; D058750:Epithelial-Mesenchymal Transition / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009361:Neoplasm Invasiveness / Q000235:genetics; D009362:Neoplasm Metastasis / Q000235:genetics; D009369:Neoplasms / Q000209:etiology / Q000235:genetics; D009389:Neovascularization, Pathologic / Q000235:genetics; D012323:RNA Processing, Post-Transcriptional; D062085:RNA, Long Noncoding / Q000235:genetics* / Q000378:metabolism; D015398:Signal Transduction
C557041:MALAT1 long non-coding RNA, human; D062085:RNA, Long Noncoding