Posttransplant Lymphoproliferative Disorder Manifesting as Intestinal Epstein-Barr Virus-Positive Anaplastic Large-Cell Lymphoma in an Adult Renal Transplant Recipient.
Posttransplant lymphoproliferative disorder is a relatively common posttransplant malignancy affecting as many as 10% of all solid-organ recipients. Most cases of posttransplant lymphoproliferative disorder are of B-cell origin, with common Epstein-Barr virus association. Posttransplant lymphoproliferative disorders of T-cell origin are much rarer and less frequently associated with Epstein-Barr virus. Here, we report an unusual case of Epstein-Barr virus-positive anaplastic large-cell lymphoma causing an intestinal perforation in an adult renal transplant recipient. A 52-year-old male patient with renal allograft developed cryptogenic end-stage liver failure and was accepted as a candidate for liver transplant. Before transplant, he was admitted with severe abdominal pain, which turned out to result from ileal perforation. Pathologic evaluation of the intestinal resection showed diffuse malignant lymphoid infiltration of the ileum, consistent with anaplastic large-cell lymphoma. The tumor was positive for Epstein-Barr virus genome. Anaplastic large-cell lymphoma is a rare form of T-cell posttransplant lymphoproliferative disorder that is infrequently associated with Epstein-Barr virus. The occurrence of this extraordinary form of post transplant lymphoproliferative disorder, its late onset, intestinal localization, and Epstein-Barr virus as sociation represent a unique clinical rarity.
From the Department of Pathology, Başkent University Faculty of Medicine, Ankara, Turkey.
Pelin
P
Börcek
B Handan
BH
Özdemir
Gonca
G
Özgün
Mehmet
M
Haberal
D015746:Abdominal Pain / Q000821:virology; D001706:Biopsy; D020031:Epstein-Barr Virus Infections / Q000150:complications / Q000175:diagnosis / Q000821:virology*; D017809:Fatal Outcome; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D006801:Humans; D007078:Ileal Neoplasms / Q000150:complications / Q000175:diagnosis / Q000821:virology*; D007150:Immunohistochemistry; D007416:Intestinal Perforation / Q000175:diagnosis / Q000821:virology; D016030:Kidney Transplantation / Q000009:adverse effects*; D017728:Lymphoma, Large-Cell, Anaplastic / Q000150:complications / Q000175:diagnosis / Q000821:virology*; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D016896:Treatment Outcome