The evolving world of pseudoenzymes: proteins, prejudice and zombies.
Pseudoenzymes are catalytically deficient variants of enzymes that are represented in all major enzyme families. Their regulatory functions in signalling pathways are shedding new light on the non-catalytic functions of active enzymes, and are suggesting new ways to target cellular signalling mechanisms with drugs.
Department of Biochemistry, Institute of Integrative Biology, University of Liverpool, Liverpool, L69 7ZB, UK. Patrick.eyers@liverpool.ac.uk.
Patrick A
PA
Eyers
The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, Australia. jamesm@wehi.edu.au.|Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia. jamesm@wehi.edu.au.
James M
JM
Murphy
D004798:Enzymes / Q000235:genetics / Q000378:metabolism; D019143:Evolution, Molecular; D011506:Proteins / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology
D004798:Enzymes; D011506:Proteins