Src-family tyrosine kinases and the Ca2+signal.
In this review, we shall describe the rich crosstalk between non-receptor Src-family kinases (SFKs) and the Ca2+transient generated in activated cells by a variety of extracellular and intracellular stimuli, resulting in diverse signaling events. The exchange of information between SFKs and Ca2+is reciprocal, as it flows in both directions. These kinases are main actors in pathways leading to the generation of the Ca2+signal, and reciprocally, the Ca2+signal modulates SFKs activity and functions. We will cover how SFKs participate in the generation of the cytosolic Ca2+rise upon activation of a series of receptors and the mechanism of clearance of this Ca2+signal. The role of SFKs modulating Ca2+-translocating channels participating in these events will be amply discussed. Finally, the role of the Ca2+sensor protein calmodulin on the activity of c-Src, and potentially on other SFKs, will be outlined as well. This article is part of a Special Issue entitled: ECS Meeting edited by Claus Heizmann, Joachim Krebs and Jacques Haiech.
Department of Cancer Biology, Instituto de Investigaciones Biomédicas, Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid, c/ Arturo Duperier 4, E-28029 Madrid, Spain.
Estefanía
E
Anguita
Department of Cancer Biology, Instituto de Investigaciones Biomédicas, Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid, c/ Arturo Duperier 4, E-28029 Madrid, Spain. Electronic address: antonio.villalobo@iib.uam.es.
Antonio
A
Villalobo
D000818:Animals; D020013:Calcium Signaling; D006801:Humans; D019061:src-Family Kinases / Q000378:metabolism*
D019061:src-Family Kinases
Calcium; Calmodulin; Cell signaling; Channels; Phospho-tyrosine phosphatases; Receptors; Src kinases