The Association Between MCT1 T1470A Polymorphism and Power-Oriented Athletic Performance.
The purpose of this study was to investigate the effects of theMCT1T1470A polymorphism (rs1049434) on power-oriented performance and lactate concentration during or after cycling sprints in Japanese wrestlers. Participants (199 wrestlers and 649 controls) were genotyped for theMCT1T1470A genotype (rs1049434) using the TaqMan®Assay. All wrestlers were international (n=77) or national (n=122) level athletes. Among them, 46 wrestlers performed 2 anaerobic performance tests, a 30-s Wingate Anaerobic test (WAnT) and a series of 10 maximal effort 10-s sprints on a cycle ergometer. Blood lactate levels were measured before, during, and after the tests. In the A-allele recessive model (AA vs. TA+TT), the frequency of the AA genotype was significantly higher in all wrestlers than in controls (p=0.037). Wrestlers with AA genotype had lower blood lactate concentrations than those with TA+TT genotype at 10 min after the WAnT and following the 5thand the final set of repeated cycling sprints (p<0.05). The AA genotype of theMCT1T1470A polymorphism is over-represented in wrestlers compared with controls and is associated with lower blood lactate concentrations after 30-s WAnT and during intermittent sprint tests in Japanese wrestlers.
Faculty of Sport Science, Nippon Sport Science University, Tokyo, Japan.
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Kikuchi
Graduate School of Health and Sports Science, Juntendo University, Chiba, Japan.
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Fuku
Graduate School of Medicine, Gunma University, Maebashi-city, Japan.
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Matsumoto
Faculty of Sport Science, Nippon Sport Science University, Tokyo, Japan.
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Matsumoto
Department of Health Promotion and Exercise, National Institute of Health and Nutrition, NIBIOHN, Tokyo, Japan.
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Murakami
Department of Health Promotion and Exercise, National Institute of Health and Nutrition, NIBIOHN, Tokyo, Japan.
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Miyachi
Faculty of Medical Science, Nippon Sport Science University, Tokyo, Japan.
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Nakazato
D044466:Asian People; D056352:Athletes; D054874:Athletic Performance; D016022:Case-Control Studies; D005080:Exercise Test; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007564:Japan; D019344:Lactic Acid / Q000097:blood; D008297:Male; D027501:Monocarboxylic Acid Transporters / Q000235:genetics*; D011110:Polymorphism, Genetic; D027981:Symporters / Q000235:genetics*; D014952:Wrestling; D000099233:Monocarboxylate Transport Protein 1
D019344:Lactic Acid; D027501:Monocarboxylic Acid Transporters; D027981:Symporters; D000099233:Monocarboxylate Transport Protein 1