IL-10 and PRKDC polymorphisms are associated with glioma patient survival.
Interleukin-10 (IL-10) and DNA repair gene PRKDC mutations are implicated in the development of multiple human cancers, including glioma. We investigated associations between IL-10 and PRKDC gene polymorphisms and prognosis in low- and high-grade glioma patients. We analyzed the associations of one IL-10 and one PRKDC single nucleotide polymorphism with patient clinical factors in 481 glioma patients using Cox proportional hazard models and Kaplan-Meier curves. We also assessed associations between patient clinical characteristics and prognosis. Our data showed that the extent of tumor resection (gross-total resection) and application of chemotherapy were associated with improved patient outcomes in all glioma cases. Additionally, univariate (Log-rank p = 0.019) and multivariate Cox regression analyses (p = 0.022) showed that the IL-10 rs1800871 C/T genotype correlates with improved overall survival in cases of low-grade glioma, whereas the PRKDC rs7003908 C/C genotype correlated with reduced overall and progression-free survival in high-grade glioma patients in univariate (Log-rank p = 0.000 and p = 0.000, respectively) and multivariate Cox regression analyses (p = 0.001; p = 0.002, respectively). These results suggest that IL-10 rs1800871 and PRKDC rs7003908 may be useful biomarkers for predicting glioma patient outcome. Further functional studies are needed to evaluate the mechanisms by which these polymorphisms affect glioma progression.
Department of Neurosurgery, First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an 710061, China.|Department of Neurosurgery, Xi'an First Hospital, Xi'an 710002, China.
Mingjun
M
Hu
Inner Mongolia Medical University, Hohhot, Inner Mongolia, 010050, China.|Department of Orthopedics and Traumatology, The 2nd Affiliated Hospital of Inner Mongolia University, Hohhot, Inner Mongolia, 010030, China.
Jieli
J
Du
Department of Neurology, Shangluo Central Hospital, Shangluo 726000, China.
Lihong
L
Cui
Department of Neurosurgery, First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an 710061, China.
Tingqin
T
Huang
Department of Neurosurgery, First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an 710061, China.
Xiaoye
X
Guo
Department of Neurosurgery, First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an 710061, China.
Yonglin
Y
Zhao
Department of Neurosurgery, First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an 710061, China.
Xudong
X
Ma
Key Laboratory of Resource Biology and Biotechnology in Western China, Northwest University, Ministry of Education, School of Life Sciences, Northwest University, Xi'an 710069, China.
Tianbo
T
Jin
Department of Neurosurgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an 710038, China.
Gang
G
Li
Department of Neurosurgery, First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an 710061, China.
Jinning
J
Song
D000328:Adult; D014408:Biomarkers, Tumor / Q000191:economics*; D001932:Brain Neoplasms / Q000235:genetics* / Q000401:mortality / Q000473:pathology / Q000628:therapy; D002681:China; D051747:DNA-Activated Protein Kinase / Q000235:genetics*; D018450:Disease Progression; D018572:Disease-Free Survival; D005260:Female; D020022:Genetic Predisposition to Disease; D005910:Glioma / Q000235:genetics* / Q000401:mortality / Q000473:pathology / Q000628:therapy; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D053208:Kaplan-Meier Estimate; D008297:Male; D015999:Multivariate Analysis; D060787:Neoplasm Grading; D009687:Nuclear Proteins / Q000235:genetics*; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D016016:Proportional Hazards Models; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome
D014408:Biomarkers, Tumor; C508609:IL10 protein, human; D009687:Nuclear Proteins; D016753:Interleukin-10; D051747:DNA-Activated Protein Kinase; C497263:PRKDC protein, human
IL-10; PRKDC; biomarker; glioma; polymorphism