A serum nuclear magnetic resonance-based metabolomic signature of antiphospholipid syndrome.
Antiphospholipid syndrome (APS) is a rheumatic inflammatory chronic autoimmune disease inducing hypercoagulable state associated with vascular thrombosis and pregnancy loss in women. Cardiac, cerebral and vascular strokes in these patients are responsible for reduction in life expectancy. Timely diagnosis and accurate monitoring of disease are decisive to improve the accuracy of therapy. In the present work, we present a NMR-based metabolomic study of blood sera of APS patients. Our data show that individuals suffering APS have a characteristic metabolomic profile with abnormalities associated to the metabolism of methyl group donors, ketone bodies and amino acids. We have identified for the first time the metabolomic fingerprint characterizing APS disease having potential application to improve APS timely diagnosis and appropriate therapeutic approaches.
Department of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132 - 84084 Fisciano, Salerno, Italy.
Angelica
A
Palisi
Department of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132 - 84084 Fisciano, Salerno, Italy.
Manuela
M
Grimaldi
U.O.C. Clinical Pathology D.E.A. III Umberto I, Nocera Inferiore, Salerno, Italy.
Paola
P
Sabatini
Department of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132 - 84084 Fisciano, Salerno, Italy.
Paola
P
Montoro
Department of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132 - 84084 Fisciano, Salerno, Italy.
Mario
M
Scrima
Department of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132 - 84084 Fisciano, Salerno, Italy.
Manuela
M
Rodriquez
Department of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132 - 84084 Fisciano, Salerno, Italy. Electronic address: dursi@unisa.it.
Anna Maria
AM
D'Ursi
D016736:Antiphospholipid Syndrome / Q000097:blood* / Q000175:diagnosis; D016022:Case-Control Studies; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D055432:Metabolomics; D012727:Sex Characteristics
Antiphospholipid syndrome; Autoimmunity; Metabolomics; NMR