Reconstruction for Limited-Projection Fluorescence Molecular Tomography Based on a Double-Mesh Strategy.
Limited-projection fluorescence molecular tomography (FMT) has short data acquisition time that allows fast resolving of the three-dimensional visualization of fluorophore within small animalin vivo. However, limited-projection FMT reconstruction suffers from severe ill-posedness because only limited projections are used for reconstruction. To alleviate the ill-posedness, a feasible region extraction strategy based on a double mesh is presented for limited-projection FMT. First, an initial result is rapidly recovered using a coarse discretization mesh. Then, the reconstructed fluorophore area in the initial result is selected as a feasible region to guide the reconstruction using a fine discretization mesh. Simulation experiments on a digital mouse and small animal experimentin vivoare performed to validate the proposed strategy. It demonstrates that the presented strategy provides a good distribution of fluorophore with limited projections of fluorescence measurements. Hence, it is suitable for reconstruction of limited-projection FMT.
School of Information Sciences and Technology, Northwest University, Xi'an, Shaanxi 710069, China.
Huangjian
0000-0002-0684-4402
H
Yi
School of Information Sciences and Technology, Northwest University, Xi'an, Shaanxi 710069, China.
Xu
X
Zhang
School of Information Sciences and Technology, Northwest University, Xi'an, Shaanxi 710069, China.
Jinye
J
Peng
School of Information Sciences and Technology, Northwest University, Xi'an, Shaanxi 710069, China.
Fengjun
F
Zhao
School of Information Sciences and Technology, Northwest University, Xi'an, Shaanxi 710069, China.
Xiaodong
X
Wang
School of Information Sciences and Technology, Northwest University, Xi'an, Shaanxi 710069, China.
Yuqing
Y
Hou
School of Life Science and Technology, Xidian University, Xi'an, Shaanxi 710071, China.
Duofang
0000-0002-7919-6979
D
Chen
School of Information Sciences and Technology, Northwest University, Xi'an, Shaanxi 710069, China.
Xiaowei
0000-0003-2126-178X
X
He
D000818:Animals; D003198:Computer Simulation; D005453:Fluorescence; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods; D016014:Linear Models; D051379:Mice; D008807:Mice, Inbred BALB C; D008954:Models, Biological; D057054:Molecular Imaging / Q000379:methods*; D055620:Optical Phenomena; D017785:Photons; D041622:Tomography, Optical / Q000379:methods*