Linear Sclerodermoid Lupus Erythematosus Profundus in a Child.
Lupus erythematosus panniculitis, also known as lupus profundus, is a variant in the clinicopathological spectrum of lupus erythematosus (LE) affecting about 2%-3% of LE patients. A linear configuration of LE panniculitis has been reported rarely with rare reports describing the coexistence of different forms of cutaneous LE and localized morphea. In this study, the authors present a 9-year-old girl with linear arrangement of subcutaneous nodules on her left forearm. Microscopic findings from 2 biopsies included lymphocytes at the dermoepidermal junction with mild interface dermatitis, a dense lymphocytic infiltrate that was concentrated around adnexae and subcutaneous fat in concert with thickened collagen bundles and mild widening of fibrous septae surrounding fat lobules. Although the clinical differential diagnosis included panniculitis or a sporotrichoid infection, 1 biopsy showed a dense lymphocytic infiltrate histologically bordered on that of cutaneous lymphoid hyperplasia or a late stage of Lyme disease, and a second also demonstrated more prominent sclerodermoid collagen bundles rendering the diagnosis of linear sclerodermoid LE profundus.
*Ackerman Academy of Dermatopathology, New York, NY; †Department of Dermatology, Kasr Alainy Faculty of Medicine, Cairo University, Giza, Egypt; ‡Departments of Internal Medicine and Pathology and Laboratory Medicine, Texas A&M University Health Science Center, Dallas, TX; §Department of Pediatrics, Joseph M. Sanzari Children's Hospital, Hackensack University Medical Center, Hackensack, NJ; and ¶Department of Dermatology, New York Presbyterian Hospital, Columbia University Medical Center, New York, NY.
Amira
A
Elbendary
John
J
Griffin
Suzanne
S
Li
Brook
B
Tlougan
Jacqueline M
JM
Junkins-Hopkins
D000273:Adipose Tissue / Q000187:drug effects / Q000276:immunology / Q000473:pathology*; D001706:Biopsy; D002648:Child; D005260:Female; D005542:Forearm; D006801:Humans; D007150:Immunohistochemistry; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008214:Lymphocytes / Q000473:pathology; D015435:Panniculitis, Lupus Erythematosus / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D012074:Remission Induction; D012594:Scleroderma, Localized / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D012867:Skin / Q000187:drug effects / Q000276:immunology / Q000473:pathology*; D016896:Treatment Outcome
D007166:Immunosuppressive Agents