Evaluation of symptoms & spirometry in children treated for asthma.
OBJECTIVE
Spirometry plays an important role in the assessment and long term monitoring of patients with asthma. Difficulty in performing spirometry in children has resulted in a paucity of Indian studies using spirometry regularly for research in the paediatric population. This study was undertaken to assess the clinical improvement and changes in spirometric measurements with treatment in children with newly diagnosed asthma and to compare the changes in the symptom score and spirometric measurements.


METHODS
This prospective study included 32 children between 6 to 12 yr of age (enrolled over a period of one year with follow up of six months) who were newly diagnosed as cases of asthma on the basis of symptoms and medical history. Baseline symptom score and spirometric measurements were determined at the first visit. The children were treated and followed up at six weeks, three and six months of initiating treatment. Symptom score and spirometric measurements were repeated at every visit.


RESULTS
Significant improvement in symptom score was evident at six weeks of therapy ( P<0.05) while the lung function parameters FEV 1 (forced expiratory volume in 1 second) and FVC (forced vital capacity) showed significant improvement at three months of therapy. Peak expiratory flow rate (PEFR) was found to improve at six months. There was a positive linear correlation between the changes in symptom score and FEV 1, FVC and PEFR with treatment.


CONCLUSIONS
Symptomatic improvement became apparent before the improvement in spirometric parameters in children with asthma (after treatment initiation).
Department of Pediatrics, Seth G.S. Medical College & KEM Hospital, Mumbai, India.
Shobi
S
Anandi
Department of Pediatrics, Seth G.S. Medical College & KEM Hospital, Mumbai, India.
Milind S
MS
Tullu
Department of Pediatrics, Seth G.S. Medical College & KEM Hospital, Mumbai, India.
Keya
K
Lahiri
D001249:Asthma / Q000175:diagnosis* / Q000503:physiopathology / Q000628:therapy*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D010366:Peak Expiratory Flow Rate; D012129:Respiratory Function Tests; D013147:Spirometry / Q000379:methods*; D014797:Vital Capacity