A Genome-Wide Assay for MSI.
A recent study from the University of Washington in Seattle indicates that microsatellite instability, classically associated with colorectal, stomach, and endometrial cancers, is a much more extensive phenotype than previously appreciated. The researchers developed MOSAIC, a method to assess microsatellite instability on a comprehensive, genome-wide scale, and identified tumors positive for this phenotype in 14 of 18 different cancers evaluated.
D004268:DNA-Binding Proteins / Q000235:genetics; D005260:Female; D055106:Genome-Wide Association Study / Q000379:methods*; D006801:Humans; D016547:Kinesins / Q000235:genetics; D008297:Male; D053842:Microsatellite Instability; D009369:Neoplasms / Q000235:genetics*; D015513:Oncogene Proteins / Q000235:genetics; D044767:Ubiquitin-Protein Ligases
D004268:DNA-Binding Proteins; D015513:Oncogene Proteins; C496945:RNF43 protein, human; D044767:Ubiquitin-Protein Ligases; C502598:KIF14 protein, human; D016547:Kinesins