An Analysis of Behavioral and Genetic Risk Factors for Chemotherapy-Induced Nausea and Vomiting in Japanese Subjects.
There are individual differences in the frequency of chemotherapy-induced nausea and vomiting (CINV) in cancer patients. We investigated the individual variability in susceptibility to CINV with focus on both behavioral factors and genetic factors in Japanese cancer patients. We performed a prospective study to investigate the association between patient attributes (backgrounds and habits as well as gene polymorphisms) and anorexia, nausea, or vomiting in 55 Japanese cancer patients undergoing chemotherapy at Nagoya University Hospital. We found that gender (female), use of non-steroidal anti-inflammatory drugs, susceptibility to motion sickness, and anxiety were associated with the frequency of CINV. Gene polymorphisms of rs1076560 (dopamine D2receptor gene), rs6766410 (serotonin 5-HT3Creceptor gene) and rs4680 (catechol-O-methyltransferase gene) were also associated. Our data suggest that these attributes may thus be risk factors for CINV. Our results provide novel information that can be used to predict the incidence of CINV in Japanese patients undergoing chemotherapy; this can help provide a substantial improvement in supportive care for patients with different types of cancer.
Division of Clinical Sciences and Neuropsychopharmacology, Faculty and Graduate School of Pharmacy, Meijo University.
Naoki
N
Mukoyama
Akira
A
Yoshimi
Aya
A
Goto
Haruka
H
Kotani
Kazuhiro
K
Ishikawa
Noriko
N
Miyazaki
Masayuki
M
Miyazaki
Kiyofumi
K
Yamada
Fumitaka
F
Kikkawa
Yoshinori
Y
Hasegawa
Norio
N
Ozaki
Yukihiro
Y
Noda
D000368:Aged; D000428:Alcohol Drinking / Q000235:genetics; D000855:Anorexia / Q000139:chemically induced* / Q000235:genetics; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000009:adverse effects*; D001007:Anxiety / Q000150:complications; D044466:Asian People / Q000235:genetics; D001519:Behavior; D002394:Catechol O-Methyltransferase / Q000235:genetics; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009041:Motion Sickness / Q000150:complications; D009325:Nausea / Q000139:chemically induced* / Q000235:genetics; D009369:Neoplasms / Q000150:complications / Q000188:drug therapy / Q000235:genetics; D011110:Polymorphism, Genetic; D017448:Receptors, Dopamine D2 / Q000235:genetics; D044406:Receptors, Serotonin, 5-HT3 / Q000235:genetics; D012307:Risk Factors; D014839:Vomiting / Q000139:chemically induced* / Q000235:genetics
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000970:Antineoplastic Agents; C581293:DRD2 protein, human; D017448:Receptors, Dopamine D2; D044406:Receptors, Serotonin, 5-HT3; D002394:Catechol O-Methyltransferase