Tetracyclic indole alkaloids with antinematode activity from Uncaria rhynchophylla.
A new tetracyclic indole alkaloid, 17-O-methyl-3,4,5,6-tetradehydrogeissoschizine, together with seven known ones, were isolated from the aerial part of Uncaria rhynchophylla. Their structures were unambiguously elucidated by spectroscopic methods and comparing with the literature data. Among them, compounds 1, 3, 4 and 6-8 showed potent to moderate antinematode activities against Panagrellus redivevus at a concentration of 250 μg/mL.
a Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology , Chinese Academy of Tropical Agriculture Sciences , Haikou , China.
Fandong
F
Kong
a Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology , Chinese Academy of Tropical Agriculture Sciences , Haikou , China.
Qingyun
Q
Ma
a Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology , Chinese Academy of Tropical Agriculture Sciences , Haikou , China.
Shengzhuo
S
Huang
b College of Food Science and Technology , Nanjing Agricultural University , Nanjing , China.
Shuang
S
Yang
b College of Food Science and Technology , Nanjing Agricultural University , Nanjing , China.
Linran
L
Fu
a Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology , Chinese Academy of Tropical Agriculture Sciences , Haikou , China.
Liman
L
Zhou
a Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology , Chinese Academy of Tropical Agriculture Sciences , Haikou , China.
Haofu
H
Dai
b College of Food Science and Technology , Nanjing Agricultural University , Nanjing , China.
Zhifang
Z
Yu
a Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology , Chinese Academy of Tropical Agriculture Sciences , Haikou , China.
Youxing
Y
Zhao
D000969:Antinematodal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D035261:Plant Components, Aerial / Q000737:chemistry; D032070:Uncaria / Q000737:chemistry*
D000969:Antinematodal Agents; D026121:Indole Alkaloids
Uncaria rhynchophylla; alkaloids; antinematode activities