The H blood group system.
The H blood group system, ISBT symbol H (018), consists of a single antigen (H) defined by a terminal fucose residue found on red blood cells and in secretions formed by the action of α-1,2-fucosyltransferases 1 (α2FucT1) and 2 (α2FucT2), respectively. Mutant alleles of the corresponding FUT1 and FUT2 genes result in either a H– phenotype (Bombay phenotype, Oh) or a weak H phenotype (para-Bombay, H+w). In addition, the FUT2 gene is the molecular basis of the secretor (Se) status, and homozygosity or compound heterozygosity for null alleles is associated with the nonsecretor (se) status. H– individuals have natural anti-H (mostly IgM), which can cause severe hemolytic transfusion reactions with intravascular hemolysis.
Director of Immunohematology, Institute of Transfusion Medicine and Immunohematology, German Red Cross Blood Service Baden-Württemberg-Hessen, gGmbH Gunzenbachstr. 35, 76530 Baden-Baden, Germany.
Erwin A
EA
Scharberg
Senior Biomedical Scientist Immunohaematology Specialised Laboratory Services, South African National Blood Service, South Africa.
Coral
C
Olsen
Associate Professor, Institute of Transfusion Medicine and Immunology, Heidelberg University, Medical Faculty Mannheim, and German Red Cross Blood Service Baden-Württemberg-Hessen, Mannheim, Germany.
Peter
P
Bugert
D000017:ABO Blood-Group System / Q000235:genetics / Q000276:immunology; D000483:Alleles; D000942:Antigens, Bacterial / Q000096:biosynthesis / Q000276:immunology*; D001323:Autoantibodies / Q000276:immunology; D001787:Blood Group Incompatibility; D002240:Carbohydrate Sequence; D002888:Chromosomes, Human, Pair 19 / Q000235:genetics; D004912:Erythrocytes / Q000276:immunology; D005006:Ethnicity / Q000235:genetics; D005643:Fucose / Q000378:metabolism; D005647:Fucosyltransferases / Q000235:genetics*; D056726:Genetic Association Studies; D006031:Glycosylation; D006461:Hemolysis; D006801:Humans; D007075:Immunoglobulin M / Q000276:immunology; D007194:India; D007518:Isoantibodies / Q000276:immunology; D009154:Mutation; D011499:Protein Processing, Post-Translational; D017508:Reunion; D065227:Transfusion Reaction; D000097631:Galactoside 2-alpha-L-fucosyltransferase
D000017:ABO Blood-Group System; D000942:Antigens, Bacterial; D001323:Autoantibodies; D005643:Fucose; D005647:Fucosyltransferases; D007075:Immunoglobulin M; D007518:Isoantibodies; D000097631:Galactoside 2-alpha-L-fucosyltransferase; C022863:H antigen