Multimodality imaging in nanomedicine and nanotheranostics.
Accurate diagnosis of tumors needs much detailed information. However, available single imaging modality cannot provide complete or comprehensive data. Nanomedicine is the application of nanotechnology to medicine, and multimodality imaging based on nanoparticles has been receiving extensive attention. This new hybrid imaging technology could provide complementary information from different imaging modalities using only a single injection of contrast agent. In this review, we introduce recent developments in multifunctional nanoparticles and their biomedical applications to multimodal imaging and theragnosis as nanomedicine. Most of the reviewed studies are based on the intrinsic properties of nanoparticles and their application in clinical imaging technology. The imaging techniques include positron emission tomography, single-photon emission computed tomography, computerized tomography, magnetic resonance imaging, optical imaging, and ultrasound imaging.
School of Life Sciences, Tianjin University, Tianjin Engineering Center of Micro-Nano Biomaterials and Detection-Treatment Technology, and Collaborative Innovation Center of Chemical Science and Engineering, Tianjin 300072, China; Department of Radiology and Department of Radiation Oncology, Second Affiliated Hospital of Tianjin Medical University, Tianjin 300211, China.
Xue
X
Li
Department of Radiology and Department of Radiation Oncology, Second Affiliated Hospital of Tianjin Medical University, Tianjin 300211, China.
Xue-Ning
XN
Zhang
Department of Radiology and Department of Radiation Oncology, Second Affiliated Hospital of Tianjin Medical University, Tianjin 300211, China.
Xiao-Dong
XD
Li
School of Life Sciences, Tianjin University, Tianjin Engineering Center of Micro-Nano Biomaterials and Detection-Treatment Technology, and Collaborative Innovation Center of Chemical Science and Engineering, Tianjin 300072, China.
Jin
J
Chang
accurate diagnosis; cancer nanomedicine; multifunctional nanoparticle; multimodal imaging; tumor imaging