Surgical Critical Care for the Patient with Sepsis and Multiple Organ Dysfunction.
Sepsis and multiple organ dysfunction syndrome (MODS) is common in the surgical intensive care unit. Sepsis involves infection and the patient's immune response. Timely recognition of sepsis and swift application of evidence-based interventions is critical to the success of therapy. This article reviews the nature of the septic process, existing definitions of sepsis, and current evidence-based treatment strategies for sepsis and MODS. An improved understanding of the process of sepsis and its relation to MODS has resulted in clinical definitions and scoring systems that allow for the quantification of disease severity and guidelines for treatment.
Section of General Surgery, Trauma, and Surgical Critical Care, Department of Surgery, Yale School of Medicine, 330 Cedar Street, BB310, PO Box 208062, New Haven, CT 06520-8062, USA. Electronic address: gary.kaml@yale.edu.
Gary J
GJ
Kaml
Department of Surgery, Quality and Performance Improvement, Yale-New Haven Hospital, Yale School of Medicine, 330 Cedar Street BB310, New Haven, CT 06520-8062, USA.
Kimberly A
KA
Davis
D003422:Critical Care; D006801:Humans; D009102:Multiple Organ Failure / Q000175:diagnosis / Q000209:etiology / Q000276:immunology / Q000628:therapy*; D017410:Practice Guidelines as Topic; D011379:Prognosis; D018805:Sepsis / Q000175:diagnosis / Q000209:etiology / Q000276:immunology / Q000628:therapy*; D018746:Systemic Inflammatory Response Syndrome / Q000628:therapy; D013727:Terminal Care
Multiple organ dysfunction syndrome; Sepsis; Sepsis treatment; Septic shock; Severe sepsis; Surgical critical care