Surfactant protein A: A key player in lung homeostasis.
The respiratory tract is continually exposed to various insults that are a permanent threat to the maintenance of lung homeostasis. Repair of the parenchyma structure, particularly of the alveolar epithelium, requires complex cellular strategies. Among the molecular components that play an important role in these processes are the surfactant proteins (SPs), particularly SP-A. The present review examines current evidence regarding the role of SP-A in lung host defence mechanisms through its implication in innate/adaptive immunity of the lung and epithelium integrity and repair. New information on SP-A deficiency in various forms of pulmonary diseases could help define therapeutic strategies aimed at restoring functional SP-A within the alveolar structure.
Service de pneumologie pédiatrique, Hôpital Armand Trousseau, Assistance Publique Hôpitaux de Paris, Centre national de référence des maladies respiratoires rares RespiRare, Paris 75012, France; Inserm UMRS933, Université Pierre et Marie Curie (Paris 6), Sorbonne Universités, Paris 75012, France. Electronic address: nadia.nathan@aphp.fr.
Nadia
N
Nathan
Service de pneumologie pédiatrique, Hôpital Armand Trousseau, Assistance Publique Hôpitaux de Paris, Centre national de référence des maladies respiratoires rares RespiRare, Paris 75012, France; Inserm UMRS928, Université Pierre et Marie Curie (Paris 6), Sorbonne Universités, Paris 75012, France. Electronic address: jessica.taytard@aphp.fr.
Jessica
J
Taytard
Inserm UMRS933, Université Pierre et Marie Curie (Paris 6), Sorbonne Universités, Paris 75012, France. Electronic address: philippe.duquesnoy@inserm.fr.
Philippe
P
Duquesnoy
Service de pneumologie pédiatrique, Hôpital Armand Trousseau, Assistance Publique Hôpitaux de Paris, Centre national de référence des maladies respiratoires rares RespiRare, Paris 75012, France; Inserm UMRS928, Université Pierre et Marie Curie (Paris 6), Sorbonne Universités, Paris 75012, France. Electronic address: guillaume.thouvenin@aphp.fr.
Guillaume
G
Thouvenin
Service de pneumologie pédiatrique, Hôpital Armand Trousseau, Assistance Publique Hôpitaux de Paris, Centre national de référence des maladies respiratoires rares RespiRare, Paris 75012, France; Inserm UMRS928, Université Pierre et Marie Curie (Paris 6), Sorbonne Universités, Paris 75012, France. Electronic address: harriet.corvol@aphp.fr.
Harriet
H
Corvol
Inserm UMRS933, Université Pierre et Marie Curie (Paris 6), Sorbonne Universités, Paris 75012, France; Service de génétique et d'embryologie médicales, Hôpital Armand Trousseau, Assistance Publique Hôpitaux de Paris, Paris 75012, France. Electronic address: serge.amselem@aphp.fr.
Serge
S
Amselem
Service de pneumologie pédiatrique, Hôpital Armand Trousseau, Assistance Publique Hôpitaux de Paris, Centre national de référence des maladies respiratoires rares RespiRare, Paris 75012, France; Inserm UMRS933, Université Pierre et Marie Curie (Paris 6), Sorbonne Universités, Paris 75012, France. Electronic address: annick.clement@aphp.fr.
Annick
A
Clement
D000818:Animals; D006706:Homeostasis / Q000276:immunology; D006801:Humans; D008168:Lung / Q000276:immunology / Q000378:metabolism*; D008171:Lung Diseases / Q000276:immunology / Q000378:metabolism / Q000628:therapy; D037662:Pulmonary Surfactant-Associated Protein A / Q000378:metabolism*
D037662:Pulmonary Surfactant-Associated Protein A
Collectin; Lung cancer; Lung fibrosis; Lung homeostasis; Surfactant protein A