Proteomic Approaches to Biomarker Discovery in Cutaneous T-Cell Lymphoma.
Cutaneous T-cell lymphoma (CTCL) is the most frequently encountered type of skin lymphoma in humans. CTCL encompasses multiple variants, but the most common types are mycosis fungoides (MF) and Sezary syndrome (SS). While most cases of MF run a mild course over a period of many years, other subtypes of CTCL are very aggressive. The rapidly expanding fields of proteomics and genomics have not only helped increase knowledge concerning the carcinogenesis and tumor biology of CTCL but also led to the discovery of novel markers for targeted therapy. Although multiple biomarkers linked to CTCL have been known for a relatively long time (e.g., CD25, CD45, CD45RA, and CD45R0), compared to other cancers (lymphoma, melanoma, colon carcinoma, head and neck cancer, renal cancer, and cutaneous B-cell lymphoma), information about the antigenicity of CTCL remains relatively limited and no dependable protein marker for CTCL has been discovered. Considering the aggressive nature of some types of CTCL, it is necessary to identify circulating molecules that can help in the early diagnosis, differentiation from inflammatory skin diseases (psoriasis, nummular eczema), and aid in predicting the prognosis and evolution of this pathology. This review aims to bring together some of the information concerning protein markers linked to CTCL, in an effort to further the understanding of the convolute processes involved in this complex pathology.
Department of Dermatology and Allergology, Elias Emergency University Hospital, 011461 Bucharest, Romania.
Alexandra
0000-0002-1749-4102
A
Ion
Department of Plastic and Reconstructive Surgery, "Bagdasar Arseni" Clinical Emergency Hospital, 041915 Bucharest, Romania.
Iris Maria
0000-0001-7702-448X
IM
Popa
Department of Dermatology and Allergology, Elias Emergency University Hospital, 011461 Bucharest, Romania.
Laura Maria Lucia
LM
Papagheorghe
Department of Dermatology and Allergology, Elias Emergency University Hospital, 011461 Bucharest, Romania.
Cristina
C
Lisievici
Department of Dermatology and Allergology, Elias Emergency University Hospital, 011461 Bucharest, Romania.
Mihai
0000-0002-5438-0817
M
Lupu
Department of Dermatology and Allergology, Elias Emergency University Hospital, 011461 Bucharest, Romania.
Vlad
0000-0002-5671-9378
V
Voiculescu
Department of Physiology, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania; Department of Dermatology, "Prof. N. C. Paulescu" National Institute of Diabetes, Nutrition and Metabolic Diseases, 020475 Bucharest, Romania.
Constantin
0000-0003-4530-7965
C
Caruntu
Dermatology Research Laboratory, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania; Department of Dermatology, Carol Medical Center, 020915 Bucharest, Romania.
Daniel
0000-0003-3282-3426
D
Boda
D014408:Biomarkers, Tumor / Q000378:metabolism*; D006801:Humans; D016410:Lymphoma, T-Cell, Cutaneous / Q000175:diagnosis / Q000378:metabolism* / Q000628:therapy; D040901:Proteomics / Q000379:methods*; D012878:Skin Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000628:therapy
D014408:Biomarkers, Tumor