Associating the learning curve and tumor anatomical complexity with the margins, ischemia, and complications rate after robot-assisted partial nephrectomy.
OBJECTIVE
In this paper, we report the robot-assisted partial nephrectomy (RAPN) outcomes of our institution by using the margins, ischemia, and complications (MIC) system, which was recently proposed to standardize the evaluation of partial nephrectomy outcomes and observe the effect of learning curve and tumor anatomical complexity on the results.


METHODS
We conducted a retrospective analysis of our prospectively maintained database of 144 patients treated with RAPN by one surgeon from May 2013 to May 2014. The MIC system was defined as a combination of negative surgical margins, warm ischemia time<20 min and no major complications. We stratified the patients by quartiles of distribution called RAPN eras 1, 2, 3, and 4 and RENAL score risk group categories. We determined the MIC rate in our study population. The MIC rates in each era and the RENAL score risk group were compared to assess the effect of the learning curve and tumor anatomical complexity on outcomes.


RESULTS
A total of 144 patients were included in this study. The overall MIC rate was 62.5% (90/144), and the MIC was commonly higher in recent eras (38.9%, 55.6%, 72.2%, and 83.3%, p = 0.001). The MIC rate progressively decreased along the RENAL score risk group categories (low, moderate, and high complexity, p = 0.002). When the RAPN eras and RENAL score risk group categories considered simultaneously, we determined that the previous eras showed a lower MIC rate, regardless of the RENAL score risk group categories. However, no significant difference was observed (p = 0.590).


CONCLUSIONS
The MIC system was found to be an appropriate, easy and reproducible tool to standardize the evaluation of the early outcomes of RAPN in patients. The MIC rate increased with surgical experience and decreased with tumor anatomical complexity.
Medical College, Nankai University, Tianjin 300071, China; Department of Urology, Chinese PLA General Hospital, Beijing, China.
Yongpeng
Y
Xie
Department of Urology, Chinese PLA General Hospital, Beijing, China.
Xin
X
Ma
Department of Urology, Chinese PLA General Hospital, Beijing, China.
Liangyou
L
Gu
Department of Urology, Chinese PLA General Hospital, Beijing, China.
Hongzhao
H
Li
Department of Urology, Chinese PLA General Hospital, Beijing, China.
Xiangjun
X
Lv
Department of Urology, Chinese PLA General Hospital, Beijing, China.
Yu
Y
Gao
Department of Urology, Chinese PLA General Hospital, Beijing, China.
Yuanxin
Y
Yao
Department of Urology, Chinese PLA General Hospital, Beijing, China.
Luyao
L
Chen
Department of Urology, Chinese PLA General Hospital, Beijing, China.
Yu
Y
Zhang
Department of Urology, Chinese PLA General Hospital, Beijing, China. Electronic address: xzhang@tjh.tjmu.edu.cn.
Xu
X
Zhang
D000328:Adult; D002292:Carcinoma, Renal Cell / Q000473:pathology / Q000601:surgery*; D016208:Databases, Factual; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology / Q000601:surgery*; D010535:Laparoscopy; D059032:Learning Curve; D008297:Male; D000072662:Margins of Excision; D008875:Middle Aged; D009392:Nephrectomy / Q000379:methods*; D011183:Postoperative Complications / Q000453:epidemiology*; D015203:Reproducibility of Results; D012189:Retrospective Studies; D065287:Robotic Surgical Procedures / Q000379:methods*; D016896:Treatment Outcome; D052096:Warm Ischemia
Kidney; Partial nephrectomy; Robotics