The Genetic Predisposition Score of Seven Obesity-Related Single Nucleotide Polymorphisms Is Associated with Better Metabolic Outcomes after Roux-en-Y Gastric Bypass.
Genetic variants associated with obesity have cumulative effects on obesity risk and related phenotypes. This study aimed to estimate the contribution of a genetic predisposition score (GPS) calculated from 7 obesity-related polymorphisms to the improvement of biochemical parameters 1 year after Roux-en-Y gastric bypass (RYGB).



Obese patients (n = 150; aged 47.2 ± 10.5 years) were enrolled and weight, body mass index (BMI), and biochemical parameters (glycemia and lipid profile) were evaluated preoperatively and 1 year after RYGB. A GPS was calculated with the polymorphisms rs1801282 of PPARG2, rs4994 of ADRB3, rs1800592 of UCP1, rs659366 and rs669339 of UCP2, rs7121 of GNAS1, and rs5443 of GNB3. We observed that 66.3% of the patients has a GPS >5.



During the preoperative period, the GPS showed a significant association with weight (β = -0.163; p = 0.020), BMI (β = -0.169; p = 0.038), and glucose concentrations (β = -0.177; p = 0.036). After sex and age adjustment, a higher GPS was associated with a greater reduction in glycemia (β = -0.158; p = 0.048), triglycerides (β = -0.256; p = 0.002), and total cholesterol (β = -0.172; p = 0.038) concentrations 1 year after surgery.



Our data elucidated that a higher GPS provides a greater metabolic benefit of RYGB.
Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
Carolina Ferreira
CF
Nicoletti
Marcela A Souza
MA
Pinhel
Bruno Affonso Parenti
BA
de Oliveira
Julio Sergio
JS
Marchini
Wilson
W
Salgado Junior
Wilson Araujo
WA
Silva Junior
Carla Barbosa
CB
Nonino
D000293:Adolescent; D000328:Adult; D000713:Anastomosis, Roux-en-Y / Q000379:methods; D001786:Blood Glucose / Q000378:metabolism; D005260:Female; D015390:Gastric Bypass / Q000379:methods; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000235:genetics* / Q000378:metabolism* / Q000601:surgery*; D020641:Polymorphism, Single Nucleotide; D012107:Research Design; D016896:Treatment Outcome; D055815:Young Adult
D001786:Blood Glucose