Sodium Channel Mutations and Pyrethroid Resistance in Aedes aegypti.
Pyrethroid insecticides are widely used to control insect pests and human disease vectors. Voltage-gated sodium channels are the primary targets of pyrethroid insecticides. Mutations in the sodium channel have been shown to be responsible for pyrethroid resistance, known as knockdown resistance (kdr), in various insects including mosquitoes. InAedes aegyptimosquitoes, the principal urban vectors of dengue, zika, and yellow fever viruses, multiple single nucleotide polymorphisms in the sodium channel gene have been found in pyrethroid-resistant populations and some of them have been functionally confirmed to be responsible for kdr in an in vitro expression system,Xenopusoocytes. This mini-review aims to provide an update on the identification and functional characterization of pyrethroid resistance-associated sodium channel mutations fromAedes aegypti. The collection of kdr mutations not only helped us develop molecular markers for resistance monitoring, but also provided valuable information for computational molecular modeling of pyrethroid receptor sites on the sodium channel.
Department of Entomology, Genetics and Neuroscience Programs, Michigan State University, East Lansing, MI 48824, USA. duy@msu.edu.
Yuzhe
Y
Du
Department of Entomology, Genetics and Neuroscience Programs, Michigan State University, East Lansing, MI 48824, USA. Nomuray@msu.edu.
Yoshiko
Y
Nomura
Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8N 3Z5, Canada. Boriszhorov@yahoo.com.|Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg 194223, Russia. Boriszhorov@yahoo.com.
Boris S
BS
Zhorov
Department of Entomology, Genetics and Neuroscience Programs, Michigan State University, East Lansing, MI 48824, USA. dongk@cns.msu.edu.
Ke
K
Dong
Aedes aegypti; knockdown resistance; pyrethroid insecticide; sodium channel