Development of an activity disease score in patients with uveitis (UVEDAI).
To develop a disease activity index for patients with uveitis (UVEDAI) encompassing the relevant domains of disease activity considered important among experts in this field. The steps for designing UVEDAI were: (a) Defining the construct and establishing the domains through a formal judgment of experts, (b) A two-round Delphi study with a panel of 15 experts to determine the relevant items, (c) Selection of items: A logistic regression model was developed that set ocular inflammatory activity as the dependent variable. The construct "uveitis inflammatory activity" was defined as any intraocular inflammation that included external structures (cornea) in addition to uvea. Seven domains and 15 items were identified: best-corrected visual acuity, inflammation of the anterior chamber (anterior chamber cells, hypopyon, the presence of fibrin, active posterior keratic precipitates and iris nodules), intraocular pressure, inflammation of the vitreous cavity (vitreous haze, snowballs and snowbanks), central macular edema, inflammation of the posterior pole (the presence and number of choroidal/retinal lesions, vascular inflammation and papillitis), and global assessment from both (patient and physician). From all the variables studied in the multivariate model, anterior chamber cell grade, vitreous haze, central macular edema, inflammatory vessel sheathing, papillitis, choroidal/retinal lesions and patient evaluation were included in UVEDAI. UVEDAI is an index designed to assess the global ocular inflammatory activity in patients with uveitis. It might prove worthwhile to motorize the activity of this extraarticular manifestation of some rheumatic diseases.
Rheumatology Department and Health Research Institute (IdISSC), Hospital Clínico San Carlos, C/ Profesor Martin Lagos s/n, 28040, Madrid, Spain. esperanza.pato@salud.madrid.org.
Esperanza
E
Pato
Research Unit of Spanish Society of Rheumatology, Madrid, Spain.
Mª Auxiliadora
MA
Martin-Martinez
Cancer Epidemiology Unit, National Center for Epidemiology, Instituto de Salud Carlos III, Madrid, Spain.
Adela
A
Castelló
Ophthalmology Department and Health Research Institute (IdISSC), Hospital Clínico San Carlos, Madrid, Spain.|Cooperative Research Network on Age-Related Ocular Pathology, Visual and Life Quality, Instituto de Salud Carlos III, Madrid, Spain.
Rosalía
R
Méndez-Fernandez
Rheumatology Department, Hospital Universitario Infanta Sofia, Universidad Europea de Madrid, San Sebastian de los Reyes, Madrid, Spain.
Santiago
S
Muñoz-Fernández
Ophthalmolgy Department, Hospital Universitario de León, León, Spain.
Miguel
M
Cordero-Coma
Ophthalmolgy Department, Hospital Universitario Doctor Peset, Valencia, Spain.
Lucia
L
Martinez-Costa
Rheumatology Department, Hospital Universitario Doctor Peset, Valencia, Spain.
Elia
E
Valls
Ophthalmolgy Department, Hospital de Gran Canaria Doctor Negrin, Gran Canaria, Spain.
Miguel
M
Reyes
Rheumatology Department, Hospital de Gran Canaria Doctor Negrin, Gran Canaria, Spain.
Félix
F
Francisco
Ophthalmology Department, Hospital Universitario Infanta Sofia, San Sebastian de los Reyes, Madrid, Spain.
Mar
M
Esteban
Ophthalmology Department, BioCruces Health Research Institute, Cruces University Hospital, University of the Basque Country, Barakaldo, Spain.
Alex
A
Fonollosa
Research Unit of Spanish Society of Rheumatology, Madrid, Spain.
Fernando
F
Sanchez-Alonso
Rheumatoloy Department, Hospital Universitario de Móstoles, Móstoles, Madrid, Spain.
Cruz
C
Fernández-Espartero
Ophthalmology Department, Hospital Universitario de Móstoles, Móstoles, Madrid, Spain.
Teresa
T
Diaz-Valle
ATLANTES Research Programme, Institute for Culture and Society, University of Navarra, Pamplona, Spain.
José Miguel
JM
Carrasco
Rheumatoloy Department, Hospital General Universitario de Valencia, Valencia, Spain.
Emma
E
Beltran-Catalán
Ophthalmology Department, Hospital General Universitario de Valencia, Valencia, Spain.
Marisa
M
Hernández-Garfella
Rheumatology Department, Hospital Clínic of Barcelona, Barcelona, Spain.
María Victoria
MV
Hernández
Ophthalmology Department, Hospital Clínic of Barcelona, Barcelona, Spain.
Laura
L
Pelegrin
Rheumatology Department, Hospital Universitario de Valdecilla, Santander, Spain.
Ricardo
R
Blanco
Ophthalmology Department and Health Research Institute (IdISSC), Hospital Clínico San Carlos, Madrid, Spain.|Cooperative Research Network on Age-Related Ocular Pathology, Visual and Life Quality, Instituto de Salud Carlos III, Madrid, Spain.
David
D
Diaz-Valle
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007249:Inflammation / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D014605:Uveitis / Q000175:diagnosis*
Activity index; Ocular inflammation; Outcome measures; Uveitis