Mucous Membrane Grafting Augmented with Topical Mitomycin C Application in Contracted Socket Repair Surgeries.
To evaluate the use of intraoperative topical application of mitomycin C (MMC) for managing cases of recurrent socket contraction.



A prospective comparative randomized study was carried out on 40 patients suffering from contracted sockets. They were randomly enrolled into 2 groups. Group A included 20 patients who had a surgery to treat contracted socket without augmentation with MMC. Group B patients had an MMC-augmented repair for the contracted socket. Patients were followed up over a period of 12 months for changes in inferior fornix (IF) depth and ability to retain the ocular prosthesis.



At the end of the follow-up period, postoperative IF depth was significantly deeper in group B (with MMC) than in group A (without MMC). As well, 75% of the patients in group B could maintain the prosthetic eye shell, whereas only 35% of group A could maintain the prosthesis.



This study shows that using intraoperative MMC (0.2 mg/mL) in contracted socket reconstruction plays a significant role in maintaining prosthetic eye. To the best of our knowledge, this study is the first to use MMC on a relatively large scale of patients with contracted socket. However, the follow-up period was relatively short and further work is required to verify the effect of MMC on a longer follow-up period.
Ophthalmology Department, Menoufia University , Faculty of Medicine, Shebin El Kom, Egypt .
Sameh S
SS
Mandour
Ophthalmology Department, Menoufia University , Faculty of Medicine, Shebin El Kom, Egypt .
Hesham M
HM
Elmazar
Ophthalmology Department, Menoufia University , Faculty of Medicine, Shebin El Kom, Egypt .
Hatem M
HM
Marey
Ophthalmology Department, Menoufia University , Faculty of Medicine, Shebin El Kom, Egypt .
Ahmed K Abdel
AK
Rahman
Ophthalmology Department, Menoufia University , Faculty of Medicine, Shebin El Kom, Egypt .
Rokia A
RA
Sakr
D000287:Administration, Topical; D000328:Adult; D003286:Contracture / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D016685:Mitomycin / Q000008:administration & dosage; D009092:Mucous Membrane / Q000637:transplantation*; D013508:Ophthalmologic Surgical Procedures; D011446:Prospective Studies
D016685:Mitomycin
antimetabolites; contracted socket; mitomycin C