DNA Walkers as Transport Vehicles of Nanoparticles Along a Carbon Nanotube Track.
DNA-based molecular motors are synthetic analogs of naturally occurring protein motors. Typical DNA walkers are constructed from synthetic short DNA strands and are powered by various free energy changes during hybridization reactions. Due to the constraints set by their small physical dimension and slow kinetics, most DNA walkers are characterized by ensemble measurements that result in averaged kinetics data. Here we present a synthetic DNA walker system that exploits the extraordinary physicochemical properties of nanomaterials and the functionalities of DNA molecules, which enables real-time control and monitoring of single-DNA walkers over an extended period.
School of Mechanical Engineering, Purdue University, Mechanical Engineering Building Room 2143, 585 Purdue Mall, West Lafayette, IN, 47907, USA.
Jing
J
Pan
School of Mechanical Engineering, Purdue University, Mechanical Engineering Building Room 2143, 585 Purdue Mall, West Lafayette, IN, 47907, USA.
Tae-Gon
TG
Cha
School of Mechanical Engineering, Purdue University, Mechanical Engineering Building Room 2143, 585 Purdue Mall, West Lafayette, IN, 47907, USA.
Haorong
H
Chen
School of Mechanical Engineering, Purdue University, Mechanical Engineering Building Room 2143, 585 Purdue Mall, West Lafayette, IN, 47907, USA.
Feiran
F
Li
School of Mechanical Engineering, Purdue University, Mechanical Engineering Building Room 2143, 585 Purdue Mall, West Lafayette, IN, 47907, USA. jchoi@purdue.edu.
Jong Hyun
JH
Choi
D004247:DNA / Q000737:chemistry*; D020409:Molecular Motor Proteins / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D049329:Nanostructures / Q000737:chemistry; D036103:Nanotechnology / Q000379:methods; D037742:Nanotubes, Carbon / Q000737:chemistry*; D009693:Nucleic Acid Hybridization / Q000379:methods
D020409:Molecular Motor Proteins; D037742:Nanotubes, Carbon; D004247:DNA
Carbon nanotube; DNA enzyme; DNA walker; Photo-regulation; Quantum dot