Native and Reconstituted Plasma Lipoproteins in Nanomedicine: Physicochemical Determinants of Nanoparticle Structure, Stability, and Metabolism.
Although many acute and chronic diseases are managed via pharmacological means, challenges remain regarding appropriate drug targeting and maintenance of therapeutic levels within target tissues. Advances in nanotechnology will overcome these challenges through the development of lipidic particles, including liposomes, lipoproteins, and reconstituted high-density lipoproteins (rHDL) that are potential carriers of water-soluble, hydrophobic, and amphiphilic molecules. Herein we summarize the properties of human plasma lipoproteins and rHDL, identify the physicochemical determinants of lipid transfer between phospholipid surfaces, and discuss strategies for increasing the plasma half-life of lipoprotein- and liposome-associated molecules.
Houston Methodist Hospital, Houston, Texas; Weill-Cornell Medical College, New York, New York.
Henry J
HJ
Pownall
Houston Methodist Hospital, Houston, Texas; Weill-Cornell Medical College, New York, New York.
Corina
C
Rosales
Houston Methodist Hospital, Houston, Texas.
Baiba K
BK
Gillard
Houston Methodist Hospital, Houston, Texas.
Mauro
M
Ferrari
D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D008074:Lipoproteins / Q000097:blood*; D008081:Liposomes; D050997:Nanomedicine / Q000379:methods*; D053758:Nanoparticles; D010316:Particle Size
D008074:Lipoproteins; D008081:Liposomes
apolipoproteins; lipid metabolism; lipoprotein structure; liposomes; membrane dynamics; reconstituted HDL