Repeat surgery for focal cortical dysplasias in children: indications and outcomes.
OBJECTIVE Focal cortical dysplasia (FCD) is a common cause of medically intractable epilepsy that often may be treated by surgery. Following resection, many patients continue to experience seizures, necessitating a decision for further surgery to achieve the desired seizure outcomes. Few studies exist on the efficacy of reoperation for intractable epilepsy due to FCD in pediatric cohorts, including the definition of prognostic factors correlated with clinical benefit from further resection. METHODS The authors retrospectively analyzed the medical records and MR images of 22 consecutive pediatric patients who underwent repeat FCD resection after unsuccessful first surgery at the Children's National Health System between March 2005 and April 2015. RESULTS Accounting for all reoperations, 13 (59%) of the 22 patients achieved complete seizure freedom and another 5 patients (23%) achieved significant improvement in seizure control. Univariate analysis demonstrated that concordance in electrocorticography (ECoG) and MRI localization (p = 0.005), and completeness of resection (p = 0.0001), were associated with seizure freedom after the first reoperation. Patients with discordant ECoG and MRI findings ultimately benefited from aggressive multilobe lobectomy or hemispherectomy. Repeat lesionectomies utilizing intraoperative MRI (iMRI; n = 9) achieved complete resection and seizure freedom in all cases. CONCLUSIONS Reoperation may be clinically beneficial in patients with intractable epilepsy due to FCD. Patients with concordant intraoperative ECoG and MRI localization may benefit from extended resection of residual dysplasia at the margins of the previous lesional cavity, and iMRI may offer benefits as a quality control mechanism to ensure that a complete resection has been accomplished. Patients with discordant findings may benefit from more aggressive resections at earlier stages to achieve better seizure control and ensure functional plasticity.
Departments of 1 Neurosurgery.
Matthew F
MF
Sacino
Neuropathology, and.
Cheng-Ying
CY
Ho
Neuroradiology.
Matthew T
MT
Whitehead
Neurology, Children's National Health System, Washington, DC.
Amy
A
Kao
Neurology, Children's National Health System, Washington, DC.
Dewi
D
Depositario-Cabacar
Departments of 1 Neurosurgery.
John S
JS
Myseros
Departments of 1 Neurosurgery.
Suresh N
SN
Magge
Departments of 1 Neurosurgery.
Robert F
RF
Keating
Neurology, Children's National Health System, Washington, DC.
William D
WD
Gaillard
Departments of 1 Neurosurgery.
Chima O
CO
Oluigbo
D000293:Adolescent; D001921:Brain / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery; D002648:Child; D002675:Child, Preschool; D000069279:Drug Resistant Epilepsy / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology / Q000601:surgery; D000069280:Electrocorticography / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D064795:Intraoperative Neurophysiological Monitoring / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D054220:Malformations of Cortical Development / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery*; D019635:Neurosurgical Procedures / Q000379:methods; D012086:Reoperation / Q000379:methods; D012640:Seizures / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology / Q000601:surgery; D025321:Surgery, Computer-Assisted / Q000379:methods; D016896:Treatment Outcome; D055815:Young Adult
ECoG = electrocorticography; EEG = electroencephalography; FCD = focal cortical dysplasia; VNS = vagus nerve stimulator; epilepsy surgery; focal cortical dysplasia; iMRI = intraoperative MRI; intraoperative MRI; reoperation; vEEG = video EEG