Oleanane triterpene saponins with cardioprotective activity from Clinopodium polycephalum.
Two new triterpene saponins, clinopodiside VI (1) and saikosaponin c (2), along with six known saikosaponins (3-8), were isolated from the plant of Clinopodium polycephalum. Compounds 1-3 showed moderate inhibition against H9c2 cell damage induced by H2O2.
a School of Pharmacy , Anhui University of Chinese Medicine , Hefei 230012 , China.|b Key Laboratory of Bioactive Substance and Resource Utilization of Chinese Herbal Medicine , Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences , Beijing 100193 , China.
Yu-Xia
YX
Hu
a School of Pharmacy , Anhui University of Chinese Medicine , Hefei 230012 , China.
Wei
W
Zhang
a School of Pharmacy , Anhui University of Chinese Medicine , Hefei 230012 , China.
Wen
W
Zhang
b Key Laboratory of Bioactive Substance and Resource Utilization of Chinese Herbal Medicine , Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences , Beijing 100193 , China.
Yin-Di
YD
Zhu
b Key Laboratory of Bioactive Substance and Resource Utilization of Chinese Herbal Medicine , Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences , Beijing 100193 , China.
Guo-Xu
GX
Ma
b Key Laboratory of Bioactive Substance and Resource Utilization of Chinese Herbal Medicine , Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences , Beijing 100193 , China.
Nai-Liang
NL
Zhu
c Health-cultivation Laboratory of the Ministry Education , Beijing University of Chinese Medicine , Beijing 100029 , China.
Wen
W
Sun
d The Museum of Chinese Medicine , Beijing University of Chinese Medicine , Beijing 100029 , China.
Ze-Xin
ZX
Ma
a School of Pharmacy , Anhui University of Chinese Medicine , Hefei 230012 , China.
Shi-Chun
SC
Yu
b Key Laboratory of Bioactive Substance and Resource Utilization of Chinese Herbal Medicine , Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences , Beijing 100193 , China.
Xu-Dong
XD
Xu
a School of Pharmacy , Anhui University of Chinese Medicine , Hefei 230012 , China.
Kai-Tuo
KT
Chen
b Key Laboratory of Bioactive Substance and Resource Utilization of Chinese Herbal Medicine , Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences , Beijing 100193 , China.
Jun-Shan
JS
Yang
D002316:Cardiotonic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006861:Hydrogen Peroxide / Q000494:pharmacology; D019686:Lamiaceae / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009828:Oleanolic Acid / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D012503:Saponins / Q000494:pharmacology; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
D002316:Cardiotonic Agents; D004365:Drugs, Chinese Herbal; D012503:Saponins; D014315:Triterpenes; C000612125:clinopodiside VI; C413246:oleanane; D009828:Oleanolic Acid; D006861:Hydrogen Peroxide; C025759:saikosaponin D
Clinopodium polycephalum; cardioprotective activity; triterpene saponins