Oroxylin A inhibits H2O2-induced oxidative stress in PC12 cells.
Oroxylin A, a natural flavonoid isolated from Scutellaria baicalensis, has been reported to have anti-inflammatory and antioxidant effects. However, suppression of oxidative stress and neuroapoptosis by oroxylin A is largely uninvestigated. To investigate the protective effects of oroxylin A, PC12 cells were exposed to oroxylin A and hydrogen peroxide solutions and measured. Oroxylin A signiﬁcantly reduced the levels of intracellular calcium and reactive oxygen species and increased the levels of CAT and Mn/SOD. Oroxylin A also inhibited the activation of caspase-3. These results suggest that treatment of PC12 cells with oroxylin A inhibits H2O2-induced oxidative stress.
a Radiology Department , The second hospital of Jilin University , Changchun , China.
Qinghe
Q
Han
b College of Veterinary Medicine , Jilin University , Changchun , China.
Haiyu
H
Wang
b College of Veterinary Medicine , Jilin University , Changchun , China.
Chong
C
Xiao
b College of Veterinary Medicine , Jilin University , Changchun , China.
Ben-Dong
BD
Fu
b College of Veterinary Medicine , Jilin University , Changchun , China.
Chong-Tao
CT
Du
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D053148:Caspase 3 / Q000378:metabolism; D005419:Flavonoids / Q000494:pharmacology*; D006861:Hydrogen Peroxide / Q000494:pharmacology; D018384:Oxidative Stress / Q000187:drug effects*; D016716:PC12 Cells; D010936:Plant Extracts; D051381:Rats; D017382:Reactive Oxygen Species / Q000378:metabolism; D031364:Scutellaria baicalensis; D013482:Superoxide Dismutase / Q000378:metabolism
D000975:Antioxidants; D005419:Flavonoids; D010936:Plant Extracts; D017382:Reactive Oxygen Species; C499814:Scutellaria baicalensis extract; C080669:5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one; D006861:Hydrogen Peroxide; D013482:Superoxide Dismutase; C505410:Casp3 protein, rat; D053148:Caspase 3
Oroxylin A; PC12 cells; ROS