Successful Engraftment of Human Hepatocytes in uPA-SCID and FRG®KO Mice.
Mice with humanized chimeric liver are promising in vivo tools to evaluate the efficacy of novel compounds or vaccine induced antibodies directed against pathogens that infect the human liver. In addition they can be used to study the human-type metabolism of medicinal compounds and hepatotoxicity.
Departments of Clinical Chemistry, Microbiology and Immunology, Ghent University, University Hospital Ghent, MRB2, De Pintelaan 185, Ghent, 9000, Belgium.
Lander
L
Foquet
Yecuris Corp, Tualatin, OR, USA.
Elizabeth M
EM
Wilson
Departments of Clinical Chemistry, Microbiology and Immunology, Ghent University, University Hospital Ghent, MRB2, De Pintelaan 185, Ghent, 9000, Belgium.
Lieven
L
Verhoye
Yecuris Corp, Tualatin, OR, USA.|Oregon Stem Cell Center, Oregon Health and Science University, Portland, OR, USA.
Markus
M
Grompe
Departments of Clinical Chemistry, Microbiology and Immunology, Ghent University, University Hospital Ghent, MRB2, De Pintelaan 185, Ghent, 9000, Belgium.
Geert
G
Leroux-Roels
Yecuris Corp, Tualatin, OR, USA.
John
J
Bial
Departments of Clinical Chemistry, Microbiology and Immunology, Ghent University, University Hospital Ghent, MRB2, De Pintelaan 185, Ghent, 9000, Belgium. Philip.Meuleman@ugent.be.
Philip
P
Meuleman
D000090:Acetoacetates / Q000378:metabolism / Q000633:toxicity; D000818:Animals; D017690:Cell Transplantation / Q000379:methods*; D056486:Chemical and Drug Induced Liver Injury / Q000235:genetics / Q000601:surgery*; D004195:Disease Models, Animal; D022781:Hepatocytes / Q000637:transplantation*; D006801:Humans; D006867:Hydrolases / Q000235:genetics; D008099:Liver / Q000166:cytology / Q000378:metabolism / Q000601:surgery; D051379:Mice; D018345:Mice, Knockout; D016513:Mice, SCID; D018183:Transplantation Chimera / Q000235:genetics / Q000502:physiology*; D014568:Urokinase-Type Plasminogen Activator / Q000235:genetics
D000090:Acetoacetates; C105171:fumarylacetoacetate; D006867:Hydrolases; D014568:Urokinase-Type Plasminogen Activator; C020156:fumarylacetoacetase
Humanized mouse model; In vivo; Liver; Malaria; Metabolism; Plasmodium falciparum; Viral hepatitis