Effect of Xinjiang UyghurVernonia anthelminticaWilld Injection Treatment with Silicosis Fibrosis.
Objective. To observe the curative effect of VAWI on Xinjiang Uygur patients with silicosis fibrosis.Methods. After we diagnosed the 40 patients with the first phase of silicosis, we randomly divided them into two groups: the basic treatment group (group A,n= 20) and the VAWI group (group B,n= 20). At the same time, we selected the age-matched healthy patients (n= 20). We applied the combined protein chip with SELDI-TOF-MS to carry out the serum analysis. The data were analyzed throughout data preprocessing, difference in PEAK screening, hierarchical cluster analysis, and Principal Component Analysis (PCA). We built decision tree model and predict the difference between the PEAK corresponding proteins.Results. The proteins peaks corresponding to name, predicted protein, and gene name were as follows: M2001_69, amyloid beta a4 protein, APP, and M2017_02, amyloid beta a4 protein, APP. The different expression of proteins in patients with silicosis was found before and after with VAWI treatment. The predicted proteins were as follows: M1982_50, amyloid beta a4 protein, APP; M3164_50, fibrinogen alpha chain frag, FGA; M3379_28, fibrinogen alpha chain frag, FGA; and so on.Conclusion. VAWI presented curative effect on patients with silicosis fibrosis via the alternation of proteins expression in serum.
Department of Occupational Disease Prevention and Control, The Fifth Affiliated Hospital, Xinjiang Medical University, Urumqi, Xinjiang 830011, China; Xinjiang Medical University, Urumqi, Xinjiang 830054, China.
Guitao
G
Liu
Department of Pathology, The Fifth Affiliated Hospital, Xinjiang Medical University, Urumqi, Xinjiang 830011, China.
Yingjia
Y
Liu
Xinjiang Medical University, Urumqi, Xinjiang 830054, China.
Lu
L
Jin
Xinjiang Medical University, Urumqi, Xinjiang 830054, China.
Cuidong
C
Li
Xinjiang Medical University, Urumqi, Xinjiang 830054, China.
Liping
L
Nie
Xinjiang Medical University, Urumqi, Xinjiang 830054, China.
Yanhua
Y
Wei
Department of Occupational Disease Prevention and Control, The Fifth Affiliated Hospital, Xinjiang Medical University, Urumqi, Xinjiang 830011, China.
Wenyu
W
Wang
Department of Occupational Disease Prevention and Control, The Fifth Affiliated Hospital, Xinjiang Medical University, Urumqi, Xinjiang 830011, China.
Yuhong
Y
Xu
Department of Occupational Disease Prevention and Control, The Fifth Affiliated Hospital, Xinjiang Medical University, Urumqi, Xinjiang 830011, China.
Nuziguli
N
Nusilaiti
Department of Occupational Disease Prevention and Control, The Fifth Affiliated Hospital, Xinjiang Medical University, Urumqi, Xinjiang 830011, China.
Ping
P
Hua
Xinjiang Medical University, Urumqi, Xinjiang 830054, China.
Xiujuan
X
Li
Xinjiang Medical University, Urumqi, Xinjiang 830054, China.
Xiaohua
X
Wang
Xinjiang Medical University, Urumqi, Xinjiang 830054, China.
Wenlong
W
Wei
Xinjiang Medical University, Urumqi, Xinjiang 830054, China.
Hamulati
0000-0002-5091-8456
H
Wufuer
D016000:Cluster Analysis; D003663:Decision Trees; D016002:Discriminant Analysis; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D006801:Humans; D007267:Injections; D016018:Least-Squares Analysis; D025341:Principal Component Analysis; D011658:Pulmonary Fibrosis / Q000150:complications* / Q000188:drug therapy*; D012829:Silicosis / Q000150:complications* / Q000188:drug therapy*; D035741:Vernonia / Q000737:chemistry*
D004365:Drugs, Chinese Herbal