Predictive value of serum pregnancy-associated plasma protein A for patients with ischemic cerebrovascular disease.
BACKGROUND
To investigate the role of pregnancy-associated plasma protein A (PAPP-A) in the outcome of ischemic cerebrovascular disease.


METHODS
We analyzed the levels of PAPP-A in the transient ischemic attack (TIA) patients, ischemic stroke (IS) patients and normal control, and followed up the outcome of the patients in the following 2 years. Blood samples were drawn at admission, prior to treatment with heparins.


RESULTS
The levels of PAPP-A in TIA patients, IS patients and normal control were 4.91 (2.11, 6.48) mIU/L, 6.77 (3.31, 10.23) mIU/L and 4.25 (1.76, 5.22) mIU/L, respectively. The follow-up results of TIA patients and IS patients indicated the PAPP-A concentration in the poor prognosis group were higher than those in the good prognosis group (5.90 vs 4.46 mIU/L, P<.05, 10.06 vs 5.12 mIU/L, P<.05, respectively). Serum PAPP-A concentration emerged as a predictor of risk stratification with an OR of 1.41 and 1.25 (P<.05, P<.05).


CONCLUSIONS
Higher PAPP-A concentration has a forecasting value on prognosis in ischemic cerebrovascular disease.
Department of Clinical Laboratory, The Second Hospital, Shandong University, Jinan, Shandong, China.
Shun
S
Wang
Department of Neurosurgery, The Second Hospital, Shandong University, Jinan, Shandong, China.
Jun
J
Jiang
Department of Neurosurgery, The Second Hospital, Shandong University, Jinan, Shandong, China.
Chuncheng
C
Qu
Department of Neurosurgery, The Second Hospital, Shandong University, Jinan, Shandong, China.
Chengwei
C
Wang
Department of Clinical Laboratory, The Second Hospital, Shandong University, Jinan, Shandong, China.
Zhaohui
Z
Sun
D000368:Aged; D015415:Biomarkers / Q000097:blood*; D002545:Brain Ischemia / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007249:Inflammation; D002546:Ischemic Attack, Transient / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011266:Pregnancy-Associated Plasma Protein-A / Q000032:analysis*
D015415:Biomarkers; D011266:Pregnancy-Associated Plasma Protein-A
biomarker; inflammation; ischemic stroke; pregnancy-associated plasma protein-A; transient ischemic attack