Parental pre-pregnancy BMI is a dominant early-life risk factor influencing BMI of offspring in adulthood.
We examined parental and early-life variables in order to identify risk factors for adulthood overweight and obesity in offspring. We report here on the longitudinal prevalence of overweight and obesity in Australian children born between 1989 and 1991 and followed from birth to age 22.



Data were analysed on 1355 participants from the Western Australian Pregnancy Cohort (Raine) Study, with anthropometry collected during pregnancy, at birth, one year and at three yearly intervals thereafter. Multivariate analyses and cross-sectional logistic regression quantified the timing and contribution of early-life risk factors for overweight and obesity in young-adulthood.



At five years of age 12.6% of children were overweight and 5.2% were obese. By early adulthood, the prevalence of obesity had increased to 12.8%, whilst overweight remained relatively stable at 14.2% (range from early childhood to adulthood 11-16%). Parental pre-pregnancy body mass index (BMI) was the strongest determinant of adult offspring BMI. Although rapid first year weight gain was associated with increased offspring BMI, the impact of first year weight-gain diminished over childhood, whilst the impact of parental BMI increased over time.



Parental pre-pregnancy BMI and rapid early-life weight gain predispose offspring to obesity in adulthood.
Department of Endocrinology and Diabetes Princess Margaret Hospital Subiaco WA Australia; School of Paediatrics and Child Health The University of Western Australia Crawley WA Australia.
S R
SR
Rath
Telethon Kids Institute The University of Western Australia Perth WA Australia; School of Mathematics and Statistics The University of Western Australia Crawley WA Australia.
J A
JA
Marsh
School of Women's and Infants' Health The University of Western Australia Crawley WA Australia.
J P
JP
Newnham
Department of Endocrinology and Diabetes Sir Charles Gairdner Hospital Nedlands WA Australia.
K
K
Zhu
School of Paediatrics and Child Health The University of Western Australia Crawley WA Australia.
H C
0000-0002-2172-3780
HC
Atkinson
School of Population Health The University of Western Australia Crawley WA Australia.
J
J
Mountain
Telethon Kids Institute The University of Western Australia Perth WA Australia.
W H
WH
Oddy
Mater Research University of Queensland Brisbane Qld Australia.
I P
IP
Hughes
Department of Paediatric Endocrinology and Diabetes Lady Cilento Children's Hospital Brisbane Qld Australia.
M
M
Harris
Department of Paediatric Endocrinology and Diabetes Lady Cilento Children's Hospital Brisbane Qld Australia; Institute for Molecular Bioscience The University of Queensland Brisbane Qld Australia.
G M
GM
Leong
Mater Research University of Queensland Brisbane Qld Australia; Department of Paediatric Endocrinology and Diabetes Lady Cilento Children's Hospital Brisbane Qld Australia.
A M
AM
Cotterill
Queensland Children's Medical Research Institute Brisbane Qld Australia; Children's Lung Environment and Asthma Research Group The University of Queensland Brisbane Qld Australia.
P D
PD
Sly
School of Women's and Infants' Health The University of Western Australia Crawley WA Australia.
C E
CE
Pennell
Department of Endocrinology and Diabetes Princess Margaret Hospital Subiaco WA Australia; School of Paediatrics and Child Health The University of Western Australia Crawley WA Australia.
C S
CS
Choong
BMI; Raine cohort; early‐life