MicroRNA expression profiling in Guillain-Barré syndrome.
Guillain-Barré syndrome (GBS) is an acute inflammatory autoimmune disease affecting the peripheral nervous system. MicroRNAs (miRNAs) are a class of small noncoding RNAs that play critical roles in the process of various diseases. The miRNAs in GBS were less studied. In this study, using microarray technology, we found two miRNAs including has-miR-4717-5p and has-miR-642b-5p were upregulated in patients with GBS, which were further confirmed by PCR analysis. Kyoto Encyclopedia of Genes and Genomes pathway analysis suggested that the dysregulated miRNAs may be involved in the mechanism of GBS by affecting the cellular differentiation, cell survival and axonal outgrowth.
Department of Neurology, Affiliated Hospital of Jining Medical University, Jining, Shandong, PR China.
Zhanyun
Z
Lv
Department of Neurology, Affiliated Hospital of Jining Medical University, Jining, Shandong, PR China.
Qiguang
Q
Shi
Central Laboratory, Affiliated Hospital of Jining Medical University, Jining, Shandong, PR China.
Wenhui
W
Huang
Department of Neurology, Affiliated Hospital of Jining Medical University, Jining, Shandong, PR China.
Chunye
C
Xing
Department of Neurology, Affiliated Hospital of Jining Medical University, Jining, Shandong, PR China.
Yanlei
Y
Hao
Department of Neurology, Affiliated Hospital of Jining Medical University, Jining, Shandong, PR China.
Xungang
X
Feng
Department of Neurology, Affiliated Hospital of Jining Medical University, Jining, Shandong, PR China.
Yan
Y
Yang
Department of Neurology, Affiliated Hospital of Jining Medical University, Jining, Shandong, PR China.
Aimei
A
Zhang
Department of Neurology, Affiliated Hospital of Jining Medical University, Jining, Shandong, PR China.
Qingxia
Q
Kong
Department of Neurology, Mishima Hospital, Niigata, Japan.
Nobuhiro
N
Yuki
Department of Neurology, Affiliated Hospital of Jining Medical University, Jining, Shandong, PR China; Central Laboratory, Affiliated Hospital of Jining Medical University, Jining, Shandong, PR China. Electronic address: wangyuzhong1234@163.com.
Yuzhong
Y
Wang
D016022:Case-Control Studies; D005260:Female; D020869:Gene Expression Profiling; D053263:Gene Regulatory Networks; D020275:Guillain-Barre Syndrome / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D046228:Microarray Analysis; D012333:RNA, Messenger / Q000378:metabolism; D015854:Up-Regulation / Q000502:physiology*
C000604774:MIRN4717 microRNA, human; C571933:MIRN642 microRNA, human; D035683:MicroRNAs; D012333:RNA, Messenger
Guillain-Barré syndrome; miR-4717; miR-642b; miRNAs