Local Inhibition of Macrophage and Smooth Muscle Cell Proliferation to Suppress Plaque Progression.
Atherosclerosis is a complex process responsible for a major burden of cardiovascular morbidity and mortality. Macrophages and smooth muscle cells (SMCs) are abundant within atherosclerotic plaques. This review discusses the role of macrophages and SMCs in plaque progression and provides an overview of nanoparticle-based approaches and other current methods for local targeting of atherosclerotic plaques.
Houston Methodist Research Institute, Houston, Texas.
Roman A
RA
Sukhovershin
Houston Methodist Research Institute, Houston, Texas.
Naama E
NE
Toledano Furman
Houston Methodist Research Institute, Houston, Texas.
Ennio
E
Tasciotti
Houston Methodist DeBakey Heart & Vascular Center, Houston Methodist Hospital, Houston, Texas.
Barry H
BH
Trachtenberg
D000818:Animals; D049109:Cell Proliferation; D018450:Disease Progression; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology*; D008264:Macrophages / Q000187:drug effects* / Q000473:pathology; D009131:Muscle, Smooth, Vascular / Q000187:drug effects* / Q000473:pathology; D058226:Plaque, Atherosclerotic / Q000473:pathology / Q000517:prevention & control*
D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors
atherosclerosis; macrophage; nanoparticle; nanotechnology; plaque; smooth muscle cell