Subareolar Sclerosing Ductal Hyperplasia.
Subareolar sclerosing duct hyperplasia (SSDH) remains to be fully characterized nearly 20 years after initial description. Thirty-five SSDH cases diagnosed over a 16-year period (January 2000 to December 2015) were reviewed. All patients were female (mean age = 59 years, range = 18-80) who had presented with a unilateral solitary lesion (left 22, right 13) with a mean size of 1.3 cm (range = 0.4-3.0 cm), and showed florid and papillary epithelial hyperplasia with dense sclerosis without involvement of nipple or areolar epidermis. Significant lesions concurrent within SSDH included low-grade adenosquamous carcinoma (n = 1), ductal carcinoma in situ (DCIS; n = 1), lobular carcinoma in situ (LCIS; n = 1), and atypical ductal hyperplasia (ADH; n = 13). No case of SSDH recurred in a mean follow-up of 44 months (range = 6-189). Subsequent significant lesions occurred in 6 patients: DCIS (n = 3; ipsilateral 2, contralateral 1), ipsilateral ADH (n = 2), and ipsilateral atypical lobular hyperplasia (n = 1). Long-term follow-up for patients with SSDH is indicated as DCIS can occur subsequently in either breast.
1 Weill Cornell Medicine, New York, NY, USA.|2 New York Presbyterian Hospital-Weill Cornell Medical Center,New York, NY, USA.
Esther
E
Cheng
1 Weill Cornell Medicine, New York, NY, USA.|2 New York Presbyterian Hospital-Weill Cornell Medical Center,New York, NY, USA.
Timothy M
TM
D'Alfonso
3 King Saud University, Riyadh, Kingdom of Saudi Arabia.
Maria
M
Arafah
1 Weill Cornell Medicine, New York, NY, USA.|2 New York Presbyterian Hospital-Weill Cornell Medical Center,New York, NY, USA.
Rebecca
R
Marrero Rolon
1 Weill Cornell Medicine, New York, NY, USA.|2 New York Presbyterian Hospital-Weill Cornell Medical Center,New York, NY, USA.
Paula S
PS
Ginter
1 Weill Cornell Medicine, New York, NY, USA.|2 New York Presbyterian Hospital-Weill Cornell Medical Center,New York, NY, USA.
Syed A
SA
Hoda
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001941:Breast Diseases / Q000473:pathology*; D001943:Breast Neoplasms / Q000473:pathology; D002277:Carcinoma / Q000473:pathology; D005260:Female; D006801:Humans; D006965:Hyperplasia / Q000473:pathology*; D008875:Middle Aged; D012598:Sclerosis / Q000473:pathology; D055815:Young Adult
breast; epithelial hyperplasia; nipple; radial scar; subareolar