Epigenomics in Waldenstrom's macroglobulinaemia.
Epigenomics refers to study of the epigenome, which represents changes in gene expression that are not induced by DNA sequence aberrations. For instance, DNA methylation, histone acetylation and microRNAs may modulate gene expression without altering the gene sequence. Waldenström's macroglobulinaemia (WM) is a low-grade B-cell lymphoma, classified as lymphoplasmacytic lymphoma, characterized by the presence of clonal lymphoplasmacytic cells in the bone marrow and serum monoclonal immunoglobulin-M in the circulation. It is a rare disease and, although indolent, it remains incurable with a median overall survival of 5-6 years. Most patients succumb to disease progression. WM cells present with aberrant histone hypoacetylation that may be explained, at least in part, via deregulated microRNAs, thus suggesting the use of histone deacetylase inhibitors or microRNA-based therapies in this disease.
ASST Spedali Civili, Department of Medical Oncology, CREA Laboratory, Brescia, Italy; Dana-Farber Cancer Institute, Department of Medical Oncology, Boston, MA, USA.
Antonio
A
Sacco
ASST Spedali Civili, SITRA, Brescia, Italy.
Adriano
A
Fenotti
ASST Spedali Civili, Collegio IPASVI, Brescia, Italy.
Stefano
S
Bazzana
ASST Spedali Civili, Department of Medical Oncology, CREA Laboratory, Brescia, Italy.
Luisa
L
Imberti
ASST Spedali Civili, Department of Medical Oncology, CREA Laboratory, Brescia, Italy.
Giuseppe
G
Rossi
Dana-Farber Cancer Institute, Department of Medical Oncology, Boston, MA, USA.
Christopher J
CJ
Patterson
Dana-Farber Cancer Institute, Department of Medical Oncology, Boston, MA, USA.
Steven P
SP
Treon
Dana-Farber Cancer Institute, Department of Medical Oncology, Boston, MA, USA.
Irene M
IM
Ghobrial
ASST Spedali Civili, Department of Medical Oncology, CREA Laboratory, Brescia, Italy; Dana-Farber Cancer Institute, Department of Medical Oncology, Boston, MA, USA. Electronic address: aldomaria.roccaro@asst-spedalicivili.it.
Aldo M
AM
Roccaro
D000107:Acetylation; D000818:Animals; D019175:DNA Methylation / Q000235:genetics; D004273:DNA, Neoplasm / Q000235:genetics / Q000378:metabolism; D018572:Disease-Free Survival; D044127:Epigenesis, Genetic; D057890:Epigenomics; D015972:Gene Expression Regulation, Neoplastic; D006657:Histones / Q000235:genetics / Q000378:metabolism; D006801:Humans; D016393:Lymphoma, B-Cell / Q000235:genetics / Q000378:metabolism / Q000401:mortality / Q000628:therapy; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism; D009363:Neoplasm Proteins / Q000235:genetics / Q000378:metabolism; D010950:Plasma Cells / Q000378:metabolism / Q000473:pathology; D012334:RNA, Neoplasm / Q000235:genetics / Q000378:metabolism; D015996:Survival Rate; D008258:Waldenstrom Macroglobulinemia / Q000235:genetics* / Q000378:metabolism* / Q000401:mortality / Q000628:therapy
D004273:DNA, Neoplasm; D006657:Histones; D035683:MicroRNAs; D009363:Neoplasm Proteins; D012334:RNA, Neoplasm
Epigenomic; Histone acetylation; Waldenström's macroglobulinaemia; microRNAs