Helicobacter pyloriovercomes natural immunity in repeated infections.
Repeated experimental reinfection of two subjects indicates thatHelicobacter pyloriinfection does not promote an immune response protective against future reinfection. Our results highlight the importance of preventing reinfection after eradication, through public health initiatives, and possibly treatment of family members. They indicate difficulties for vaccine development, especially therapeutic vaccines.
Department of Gastroenterology Sir Charles Gairdner Hospital Perth Western Australia Australia.
Björn
B
Stenström
The Marshall Centre for Infectious Diseases Research and Training School of Pathology and Laboratory Medicine The University of Western Australia Perth Western Australia Australia.
Helen M
HM
Windsor
The Marshall Centre for Infectious Diseases Research and Training School of Pathology and Laboratory Medicine The University of Western Australia Perth Western Australia Australia; Ondek Pty Ltd QEII Medical Centre Perth Western Australia Australia.
Alma
A
Fulurija
The Marshall Centre for Infectious Diseases Research and Training School of Pathology and Laboratory Medicine The University of Western Australia Perth Western Australia Australia; Ondek Pty Ltd QEII Medical Centre Perth Western Australia Australia; Swiss Vitamin Institute Épalinges Switzerland.
Mohammed
M
Benghezal
Department of Anatomical Pathology PathWest, QEII Medical Centre Perth Western Australia Australia.
M Priyanthi
MP
Kumarasinghe
Department of Gastroenterology Sir Charles Gairdner Hospital Perth Western Australia Australia; The Marshall Centre for Infectious Diseases Research and Training School of Pathology and Laboratory Medicine The University of Western Australia Perth Western Australia Australia; Venasis Kanamachi Medical Clinic Tokyo-to Japan.
Kazufumi
K
Kimura
The Marshall Centre for Infectious Diseases Research and Training School of Pathology and Laboratory Medicine The University of Western Australia Perth Western Australia Australia.
Chin Yen
CY
Tay
Department of Gastroenterology Sir Charles Gairdner Hospital Perth Western Australia Australia.
Charlie H
CH
Viiala
Department of Gastroenterology Sir Charles Gairdner Hospital Perth Western Australia Australia.
Hooi C
HC
Ee
The Marshall Centre for Infectious Diseases Research and Training School of Pathology and Laboratory Medicine The University of Western Australia Perth Western Australia Australia; Ondek Pty Ltd QEII Medical Centre Perth Western Australia Australia.
Wei
W
Lu
Ondek Pty Ltd QEII Medical Centre Perth Western Australia Australia; Telethon Kids Institute Perth Western Australia Australia.
Tobias D
TD
Schoep
The Marshall Centre for Infectious Diseases Research and Training School of Pathology and Laboratory Medicine The University of Western Australia Perth Western Australia Australia.
K Mary
KM
Webberley
The Marshall Centre for Infectious Diseases Research and Training School of Pathology and Laboratory Medicine The University of Western Australia Perth Western Australia Australia; UM Marshall Centre University of Malaya Kuala Lumpur Malaysia.
Barry J
BJ
Marshall
Helicobacter; natural immunity; reinfection; vaccination