Reduction of blood eosinophil counts in eosinophilic chronic rhinosinusitis after surgery.
OBJECTIVE
This study aimed to predict eosinophilic chronic rhinosinusitis prognosis by investigating changes in the blood eosinophil count and other disease biomarkers after surgery.


METHODS
Blood eosinophil numbers and serum interleukin-5 levels were measured in 22 eosinophilic chronic rhinosinusitis patients before and after functional endoscopic sinus surgery, and compared with equivalent measures in non-eosinophilic chronic rhinosinusitis patients and chronic rhinosinusitis without polyps patients. Differences between well-controlled eosinophilic chronic rhinosinusitis patients and those who experienced recurrence were also assessed.


RESULTS
Blood eosinophil numbers and serum interleukin-5 level decreased after surgery in eosinophilic chronic rhinosinusitis patients. In this patient group, blood eosinophil counts before surgery were significantly higher in patients who experienced recurrence (825.7 ± 26.1 vs 443.9 ± 76.6 cells/μl, p < 0.05), and decreased significantly after surgery (825.7 ± 26.1 vs 76.7 ± 25.8 cells/μl, p < 0.05).


CONCLUSIONS
Blood eosinophil numbers may reflect disease severity in eosinophilic chronic rhinosinusitis patients and their prognosis after surgery.
Department of Otolaryngology - Head and Neck Surgery,Hokkaido University Graduate School of Medicine,Sapporo,Japan.
A
A
Honma
Department of Otolaryngology - Head and Neck Surgery,Hokkaido University Graduate School of Medicine,Sapporo,Japan.
D
D
Takagi
Department of Otolaryngology - Head and Neck Surgery,Hokkaido University Graduate School of Medicine,Sapporo,Japan.
Y
Y
Nakamaru
Department of Otolaryngology - Head and Neck Surgery,Hokkaido University Graduate School of Medicine,Sapporo,Japan.
A
A
Homma
Department of Otolaryngology - Head and Neck Surgery,Hokkaido University Graduate School of Medicine,Sapporo,Japan.
M
M
Suzuki
Department of Otolaryngology - Head and Neck Surgery,Hokkaido University Graduate School of Medicine,Sapporo,Japan.
S
S
Fukuda
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002908:Chronic Disease; D004724:Endoscopy; D004802:Eosinophilia / Q000097:blood* / Q000276:immunology; D004804:Eosinophils; D005260:Female; D006801:Humans; D015848:Interleukin-5 / Q000097:blood* / Q000276:immunology; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D010256:Paranasal Sinuses / Q000601:surgery*; D011379:Prognosis; D012220:Rhinitis / Q000097:blood / Q000276:immunology / Q000601:surgery*; D012852:Sinusitis / Q000097:blood / Q000276:immunology / Q000601:surgery*; D016896:Treatment Outcome; D055815:Young Adult
C508599:IL5 protein, human; D015848:Interleukin-5
Eosinophilia; Recurrence; Sinusitis