A new target for differentiation therapy in AML.
Despite major advances in understanding the genetics and epigenetics of acute myelogenous leukemia, there is still a great need to develop more specific and effective therapies. High throughput approaches involving either genetic approaches or small molecule inhibitor screens are beginning to identify promising new therapeutic targets.
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, 340 West 10th Street, Fairbanks 6200, Indianapolis, IN 46202-3082, USA.
Peilin
P
Ma
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, 340 West 10th Street, Fairbanks 6200, Indianapolis, IN 46202-3082, USA.
Weihua
W
Song
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, 340 West 10th Street, Fairbanks 6200, Indianapolis, IN 46202-3082, USA.
Jay L
JL
Hess
D002454:Cell Differentiation; D000090722:Dihydroorotate Dehydrogenase; D006801:Humans; D015470:Leukemia, Myeloid, Acute; D044925:Oxidoreductases Acting on CH-CH Group Donors
D000090722:Dihydroorotate Dehydrogenase; D044925:Oxidoreductases Acting on CH-CH Group Donors