Diabetes and Obesity as Independent Risk Factors for Osteoporosis: Updated Results from the ROIS/EMEROS Registry in a Population of Five Thousand Post-Menopausal Women Living in a Region Characterized by Heavy Environmental Pressure.
Objectives:We aimed to analyze bone mineralization and the effect of different risk factors for osteoporosis in postmenopausal women.Methods:We found 4909 postmenopausal subjects within ≥10,000 records from the ROIS/EMEROS (Ionian and Salento Osteoporosis Registry/Euro Mediterranean Registry of Osteoporosis) registry, a population study carried out in an area characterized by heavy environmental pressure between Brindisi and Taranto from 2009 to 2016. All subjects were assessed via phalangeal quantitative ultrasound (QUS) to evaluate their bone mineralization (assessed via amplitude dependent speed of sound (AD-SoS)) and the association between demineralization and the presence of other conditions or risk factors.Results:Mean age was 64 ± 9.5 years and mean body mass index (BMI) was 28.7 ± 3.5 kg/m². Pearson correlation analyses revealed a negative association between bone mineralization (AD-SoS) and BMI (p< 0.001). By using multivariate logistic regression analysis, we observed significant values of odds ratios (ORs) of osteoporosis (adjusted for age, physical activity, and the use of drugs known to increase the risk of fractures) in subjects with diabetes and obesity: 1.39 (confidence interval (CI): 1.05-1.83) and 1.46 (CI: 1.20-1.78), respectively. A statistically significant linear trend of higher ORs of osteoporosis was found for increasing values of BMI.Conclusions:Our study confirmed the high impact of obesity and type 1 and type 2 diabetes on osteoporosis.
ISBEM (Istituto Scientifico Biomedico Euro Mediterraneo), Brindisi 72100, Italy. neglia@isbem.it.
Cosimo
C
Neglia
ISBEM (Istituto Scientifico Biomedico Euro Mediterraneo), Brindisi 72100, Italy. argentiero85@gmail.com.
Alberto
A
Argentiero
ISBEM (Istituto Scientifico Biomedico Euro Mediterraneo), Brindisi 72100, Italy. chitano@isbem.it.
Giovanna
G
Chitano
ISBEM (Istituto Scientifico Biomedico Euro Mediterraneo), Brindisi 72100, Italy. agnello@isbem.it.
Nadia
N
Agnello
ISBEM (Istituto Scientifico Biomedico Euro Mediterraneo), Brindisi 72100, Italy. ciccarese@isbem.it.
Roberta
R
Ciccarese
ISBEM (Istituto Scientifico Biomedico Euro Mediterraneo), Brindisi 72100, Italy. vigilanza@isbem.it.
Antonella
A
Vigilanza
ISBEM (Istituto Scientifico Biomedico Euro Mediterraneo), Brindisi 72100, Italy. pantile@isbem.it.
Valerio
V
Pantile
ISBEM (Istituto Scientifico Biomedico Euro Mediterraneo), Brindisi 72100, Italy. argentiero@isbem.it.
Domenico
D
Argentiero
ISBEM (Istituto Scientifico Biomedico Euro Mediterraneo), Brindisi 72100, Italy. raf.quarta@libero.it.
Raffaele
R
Quarta
IOS, Southern Italy Hospital Institute, Medicina Futura Research, Naples 80100, Italy. matteo.rivezzi@gmail.com.
Matteo
M
Rivezzi
Centre for Primary Care and Public Health, Queen Mary University of London, London E1 4NS, UK. g.ditanna@qmul.ac.uk.
Gian Luca
GL
Di Tanna
IRCCS SDN Istituto di Ricerca Diagnostica e Nucleare, Naples 80133, Italy. cdisomma@unina.it.
Carolina
C
Di Somma
St. Peter's Fatebenefratelli Hospital, Rome 00186, Italy. migliore.alberto60@gmail.com.
Alberto
A
Migliore
Department of Orthopaedic Surgery and Rehabilitation, Second University of Naples, Naples 81100, Italy. giovanni.iolascon@unina2.it.
Giovanni
G
Iolascon
Department of Orthopaedic Surgery and Rehabilitation, Second University of Naples, Naples 81100, Italy. francesca.gimigliano@unina2.it.
Francesca
F
Gimigliano
ISBEM (Istituto Scientifico Biomedico Euro Mediterraneo), Brindisi 72100, Italy. distante@isbem.it.
Alessandro
A
Distante
IOS, Southern Italy Hospital Institute, Medicina Futura Research, Naples 80100, Italy. priscofreedom@hotmail.com.
Prisco
P
Piscitelli
D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D003922:Diabetes Mellitus, Type 1 / Q000150:complications*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D004787:Environmental Pollution / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007558:Italy; D016015:Logistic Models; D008875:Middle Aged; D009765:Obesity / Q000150:complications*; D016017:Odds Ratio; D015663:Osteoporosis, Postmenopausal / Q000175:diagnosis / Q000209:etiology*; D012042:Registries; D012307:Risk Factors
diabetes; environmental factors; fractures; obesity; osteoporosis; quantitative ultrasounds