Therapeutics for Brain Metastases, v3.
The role of blood-brain barrier (BBB) permeability in the efficacy of brain metastasis therapeutics is debated. Both BBB-permeable and BBB-impermeable compounds were compared in a melanoma brain metastasis model using imaging through a cranial window. Only the BBB-permeable compound inhibited both the ∼30% permeable metastases and the ∼70% impermeable metastases. Clin Cancer Res; 22(24); 5953-5. ©2016 AACRSee related article by Osswald et al., p. 6078.
Women's Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland. steegp@mail.nih.gov.
Patricia S
PS
Steeg
Women's Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland.
Alexandra
A
Zimmer
Women's Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland.
Brunilde
B
Gril
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D001812:Blood-Brain Barrier / Q000378:metabolism; D001921:Brain / Q000187:drug effects; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000556:secondary; D006801:Humans; D010539:Permeability
D000970:Antineoplastic Agents