Morphological Evaluation of Soft Tissue Augmentation Using Porous Poly-DL-Lactic Acid With Straight Holes.
OBJECTIVE
This study investigated the biological reaction to porous poly-DL-lactic acid (PDLLA) scaffolds with holes for soft tissue augmentation.


METHODS
The control group was porous PDLLA with a diameter of 5.0 mm and a height of 2.0 mm. For the 2 test groups, 7 holes were drilled from the upper to the lower base of the scaffolds; the holes had diameters of 0.5 and 1.0 mm. A scaffold was placed in the periosteum of the cranium. The height and molecular weight (Mw) of the scaffolds were measured at 4 and 8 weeks. Hematoxylin and eosin staining was used to measure the connective tissue and blood vessel areas.


RESULTS
All groups had similar scaffold heights, but the Mw decreased significantly over time. There were significant differences in the connective tissue and blood vessel areas among the control, 0.5-mm, and 1.0-mm groups at the same time point. The soft tissue was increased by drilling holes in the scaffolds.


CONCLUSIONS
Porous poly-DL-lactic acid (PDLLA) contributed favorable prognosis for soft tissue. A wider hole was associated with increased connective tissue and blood vessel areas. The scaffold height and Mw were not impacted by size of the holes.
*Doctor, Oral Implantology and Regenerative Dental Medicine, Department of Masticatory Function Rehabilitation, Tokyo Medical and Dental University, Tokyo, Japan. †Lecturer, Oral Implantology and Regenerative Dental Medicine, Department of Masticatory Function Rehabilitation, Tokyo Medical and Dental University, Tokyo, Japan. ‡Professor, Oral Implantology and Regenerative Dental Medicine, Department of Masticatory Function Rehabilitation, Tokyo Medical and Dental University, Tokyo, Japan.
Yukawa
Y
Ken
Tachikawa
T
Noriko
Akiko
A
Furuichi
Kasugai
K
Shohei
D000540:Alveolar Ridge Augmentation / Q000379:methods*; D000818:Animals; D008297:Male; D008970:Molecular Weight; D010521:Periosteum / Q000473:pathology / Q000601:surgery; D011091:Polyesters / Q000627:therapeutic use*; D016062:Porosity; D051381:Rats; D017208:Rats, Wistar; D054457:Tissue Scaffolds
D011091:Polyesters; C033616:poly(lactide)