Local gyrification index in patients with major depressive disorder and its association with tryptophan hydroxylase-2 (TPH2) polymorphism.
The tryptophan hydroxylase-2 (TPH2) gene is considered a promising genetic candidate regarding its association with a predisposition to major depressive disorder (MDD). Local gyrification reflects the early neural development of cortical connectivity, and is regarded as a potential neural endophenotype in psychiatric disorders. They aimed to investigate the alterations in the cortical gyrification of the prefrontal cortex and anterior cingulate cortex and their association with the TPH2 rs4570625 polymorphism in patients with MDD. One hundred and thirteen patients with MDD and eighty-six healthy controls underwent T1-weighted structural magnetic resonance imaging and genotyping for TPH2 rs4570625. The local gyrification index of 22 cortical regions in the prefrontal cortex and anterior cingulate cortex was analyzed using the FreeSurfer. The patients with MDD showed significant hypergyria in the right rostral anterior cingulate cortex (P = 0.001), medial orbitofrontal cortex (P = 0.003), and frontal pole (P = 0.001). There was a significant genotype-by-diagnosis interaction for the local gyrification index in the right rostral anterior cingulate cortex (P = 0.003). Their study revealed significant hypergyria of the anterior cingulate cortex and prefrontal cortex and an interactive effect between the diagnosis of MDD and the genotype in the anterior cingulate cortex. This might be associated with the dysfunction of neural circuits mediating emotion processing, which could contribute to pathophysiology of MDD. Hum Brain Mapp 38:1299-1310, 2017. © 2016 Wiley Periodicals, Inc.
Department of Psychiatry, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Republic of Korea.
Kyu-Man
KM
Han
Department of Psychiatry, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Republic of Korea.
Eunsoo
E
Won
Department of Biomedical Sciences, Korea University College of Medicine, Seoul, Republic of Korea.
June
J
Kang
Department of Psychiatry, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Republic of Korea.
Aram
A
Kim
Department of Psychiatry, Korea University Ansan Hospital, Korea University College of Medicine, Seoul, Republic of Korea.
Ho-Kyoung
HK
Yoon
Department of Medical Bioscience, Graduate School, Soonchunhyang University, Bucheon, Republic of Korea.
Hun Soo
HS
Chang
Department of Radiology, Korea University Medical Center, Korea University College of Medicine, Seoul, Republic of Korea.
Kyu Ri
KR
Son
Department of Psychiatry, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Republic of Korea.
Min-Soo
MS
Lee
Brain Convergence Research Center, Korea University Anam Hospital, Seoul, Republic of Korea.
Woo-Suk
WS
Tae
Department of Psychiatry, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Republic of Korea.|Brain Convergence Research Center, Korea University Anam Hospital, Seoul, Republic of Korea.
Byung-Joo
BJ
Ham
D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D003865:Major Depressive Disorder / Q000235:genetics* / Q000473:pathology*; D005260:Female; D005838:Genotype; D006179:Gyrus Cinguli / Q000000981:diagnostic imaging*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D011569:Psychiatric Status Rating Scales; D014365:Tryptophan Hydroxylase / Q000235:genetics*; D055815:Young Adult
C494784:TPH2 protein, human; D014365:Tryptophan Hydroxylase
TPH2 rs4570625; anterior cingulate cortex; local gyrification index; major depressive disorder; orbitofrontal cortex; prefrontal cortex