Regulation of lipid metabolism via a connection between the endoplasmic reticulum and lipid droplets.
Lipid droplets (LDs) are ubiquitous organelles that store and supply lipids to regulate cellular lipid homeostasis. Fatty acids are packaged as triglyceride and cholesterol ester into endoplasmic reticulum (ER) membranes to synthesize LDs. Cytosolic LDs move dynamically and interact with organelles, including other LDs. In this process, functional proteins for metabolism are also transferred to LDs. In this review, I focus on interactions between the ER and LDs related to lipid metabolism.
Department of Molecular Genetics and Microbiology, Duke University, 272 Jones Building Box 3580, DUMC, Durham, NC, 27710, USA. michitaka.suzuki@duke.edu.
Michitaka
M
Suzuki
D004721:Endoplasmic Reticulum / Q000378:metabolism* / Q000502:physiology; D006801:Humans; D066292:Lipid Droplets / Q000378:metabolism* / Q000502:physiology; D050356:Lipid Metabolism; D008066:Lipolysis; D051336:Mitochondrial Membranes / Q000378:metabolism; D015388:Organelles; D000070778:Perilipin-1 / Q000378:metabolism / Q000502:physiology; D000070137:Perilipins / Q000378:metabolism / Q000502:physiology; D010713:Phosphatidylcholines / Q000096:biosynthesis; D011485:Protein Binding; D059748:Proteolysis
C000602978:PLIN1 protein, human; D000070778:Perilipin-1; D000070137:Perilipins; D010713:Phosphatidylcholines
Endoplasmic reticulum; Lipid droplets; Lipid metabolism; Organelle interaction; Protein degradation