Diagnostic ability of Humphrey perimetry, Octopus perimetry, and optical coherence tomography for glaucomatous optic neuropathy.
PurposeTo evaluate and compare the diagnostic accuracy of the Humphrey Field Analyzer (HFA), Octopus perimetry, and Cirrus OCT for glaucomatous optic neuropathy.MethodsEighty-eight healthy individuals and 150 open-angle glaucoma patients were consecutive and prospectively selected. Eligibility criteria for the glaucoma group were intraocular pressure ≥21 mm Hg and glaucomatous optic nerve head morphology. All subjects underwent a reliable standard automated perimetry with the HFA and Octopus perimeter, and were imaged with the Cirrus OCT. Receiver-operating characteristic (ROC) curves were plotted for the threshold values and main indices of the HFA and Octopus, the peripapillary retinal nerve fiber layer thicknesses, and the optic nerve head parameters. Sensitivities at 85 and 95% fixed-specificities were also calculated. The best areas under the ROC curves (AUCs) were compared using the DeLong method.ResultsIn the glaucoma group, mean deviation (MD) was -5.42±4.6 dB for HFA and 3.90±3.6 dB for Octopus. The MD of the HFA (0.966; P<0.001), mean sensitivity of the Octopus (0.941; P<0.001), and average cup-to-disc (C/D) ratio measured by the Cirrus OCT (0.958; P<0.001) had the largest AUCs for each test studied. There were no significant differences among them. Sensitivities at 95% fixed-specificity were 82% for pattern standard deviation of the HFA, 81.3% for average C/D ratio of OCT, and 80% for the MD of the Octopus.ConclusionsHFA, Octopus, and Cirrus OCT demonstrated similar diagnostic accuracies for glaucomatous optic neuropathy. Visual field and OCT provide supplementary information and thus these tests are not interchangeable.
Department of Ophthalmology, Hospital General Universitario Gregorio Marañón, Instituto Oftálmico de Madrid, Madrid, Spain.|Department of Ophthalmology, Hospital Moncloa, Oftalvist, Madrid, Spain.
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Monsalve
Department of Ophthalmology, Miguel Servet University Hospital, IIS Aragon, Zaragoza, Spain.|Department of Surgery, Gynecology and Obstetrics, University of Zaragoza, Zaragoza, Spain.
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http://orcid.org/0000-0002-2914-2593
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Ferreras
Department of Ophthalmology, Miguel Servet University Hospital, IIS Aragon, Zaragoza, Spain.|Department of Surgery, Gynecology and Obstetrics, University of Zaragoza, Zaragoza, Spain.
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Calvo
Department of Ophthalmology, Hospital Universitario Araba, Vitoria, Spain.
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Urcola
Department of Neurosciences, University of Pisa, Pisa, Italy.
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Figus
Department of Ophthalmology, Hospital Moncloa, Oftalvist, Madrid, Spain.
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Monsalve
Department of Ophthalmology, University of Siena, Siena, Italy.
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Frezzotti
D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D005902:Glaucoma, Open-Angle / Q000175:diagnosis* / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D008875:Middle Aged; D009901:Optic Nerve Diseases / Q000175:diagnosis* / Q000000981:diagnostic imaging; D012372:ROC Curve; D012680:Sensitivity and Specificity; D041623:Tomography, Optical Coherence / Q000379:methods*; D058609:Visual Field Tests / Q000379:methods*