Decreased preoperative serum 25-Hydroxyvitamin D levels in colorectal cancer are associated with systemic inflammation and serrated morphology.
Deficiency of vitamin D is associated with increased risk of several types of cancer including colorectal cancer (CRC). However, factors contributing to low levels of 25-hydroxyvitamin D [25(OH)D] in CRC are not clear. Therefore, in this study serum 25(OH)D levels in 117 CRC patients and 86 controls were analyzed and correlated with the clinicopathological data including morphological subtype (serrated or conventional), quantity of tumor infiltrating immune cells, levels of systemic inflammatory markers, and disease outcome. We found that the patients had lower serum 25(OH)D levels compared to the controls. Interestingly, among the patients mismatch repair deficiency, serrated morphology, and high body mass index associated with lowest serum 25(OH)D levels. In addition, patients operated in summer or autumn had higher serum 25(OH)D levels. Furthermore, serum 25(OH)D levels inversely correlated with several systemic inflammatory markers, e.g. serum C reactive protein, but did not associate with prognosis. Mechanism leading to vitamin D deficiency in these patients are not clear but could be related to the effects of systemic inflammation. Longitudinal studies are warranted to assess vitamin D deficiency as a potential risk factor for serrated colorectal polyps and adenocarcinoma.
Cancer and Translational Medicine Research Unit, University of Oulu, POB 5000, 90014 Oulu, Finland.|Oulu University Hospital and Medical Research Center Oulu, POB 21, 90029 Oulu, Finland.
Juha P
JP
Väyrynen
Research Unit of Biomedicine and Biocenter Oulu, University of Oulu, POB 5000, 90014 Oulu, Finland.
Shivaprakash J
SJ
Mutt
Oulu University Hospital and Medical Research Center Oulu, POB 21, 90029 Oulu, Finland.|Research Unit of Biomedicine and Biocenter Oulu, University of Oulu, POB 5000, 90014 Oulu, Finland.|Department of Gastroenterology and Metabolism, Poznan University of Medical Sciences, 27/33 Szpitalna Str., 60-572, Poland.
Karl-Heinz
KH
Herzig
Cancer and Translational Medicine Research Unit, University of Oulu, POB 5000, 90014 Oulu, Finland.|Oulu University Hospital and Medical Research Center Oulu, POB 21, 90029 Oulu, Finland.
Sara A
SA
Väyrynen
Cancer and Translational Medicine Research Unit, University of Oulu, POB 5000, 90014 Oulu, Finland.|Oulu University Hospital and Medical Research Center Oulu, POB 21, 90029 Oulu, Finland.
Tiina
T
Kantola
Research Unit of Biomedicine and Biocenter Oulu, University of Oulu, POB 5000, 90014 Oulu, Finland.
Toni
T
Karhu
Cancer and Translational Medicine Research Unit, University of Oulu, POB 5000, 90014 Oulu, Finland.|Oulu University Hospital and Medical Research Center Oulu, POB 21, 90029 Oulu, Finland.
Tuomo J
TJ
Karttunen
Oulu University Hospital and Medical Research Center Oulu, POB 21, 90029 Oulu, Finland.|Research Unit of Surgery, Anesthesia and Intensive Care, University of Oulu, POB 5000, 90014 Oulu, Finland.
Kai
K
Klintrup
Oulu University Hospital and Medical Research Center Oulu, POB 21, 90029 Oulu, Finland.|Research Unit of Surgery, Anesthesia and Intensive Care, University of Oulu, POB 5000, 90014 Oulu, Finland.
Jyrki
J
Mäkelä
Cancer and Translational Medicine Research Unit, University of Oulu, POB 5000, 90014 Oulu, Finland.|Oulu University Hospital and Medical Research Center Oulu, POB 21, 90029 Oulu, Finland.
Markus J
MJ
Mäkinen
Cancer and Translational Medicine Research Unit, University of Oulu, POB 5000, 90014 Oulu, Finland.|Oulu University Hospital and Medical Research Center Oulu, POB 21, 90029 Oulu, Finland.
Anne
A
Tuomisto
D000368:Aged; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism; D015179:Colorectal Neoplasms / Q000097:blood* / Q000378:metabolism; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood* / Q000209:etiology*; D008297:Male; D011379:Prognosis; D011446:Prospective Studies; D012307:Risk Factors; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood* / Q000150:complications* / Q000378:metabolism
D015415:Biomarkers; D014807:Vitamin D; D002097:C-Reactive Protein; C104450:25-hydroxyvitamin D