Evolution of phage display technology: from discovery to application.
Phage display technology as a selection-based system is an attractive method for evolution of new biological drugs. Unique ability of phage libraries for displaying proteins on bacteriophage surfaces enable them to make a major contribution in diverse fields of researches related to the diagnosis and therapy of diseases. One of the great challenges facing researchers is the modification of phage display technology and the development of new applications. This article reviews the molecular basis of phage display library, and summarizes the novel and specific applications of this technique in the field of biological drugs development including therapeutic antibodies, peptides, vaccines, and catalytic antibodies.
a Drug Applied Research Center, Tabriz University of Medical Sciences , Tabriz , Iran.|b Student Research Committee , Tabriz University of Medical Sciences , Tabriz , Iran.
Leila
L
Rahbarnia
a Drug Applied Research Center, Tabriz University of Medical Sciences , Tabriz , Iran.
Safar
S
Farajnia
a Drug Applied Research Center, Tabriz University of Medical Sciences , Tabriz , Iran.
Hossein
H
Babaei
c Immunology Research Center, Tabriz University of Medical Sciences , Tabriz , Iran.
Jafar
J
Majidi
d Department of Biotechnology , School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences , Tabriz , Iran.
Kamal
K
Veisi
a Drug Applied Research Center, Tabriz University of Medical Sciences , Tabriz , Iran.
Vahideh
V
Ahmadzadeh
e Department of Medical Biotechnology, Faculty of Advanced Medical Sciences , University Of Medical Sciences Tabriz , Tabriz , Iran.
Bahman
B
Akbari
D001435:Bacteriophages / Q000235:genetics*; D015195:Drug Design
Bacteriophages; abzyme; antibody; drug discovery; peptide; phage library; vaccine