Glanzmann thrombasthenia in pregnancy: Optimising maternal and fetal outcomes.
Glanzmann thrombasthenia is a rare autosomal recessive haemorrhagic disorder. The risks of miscarriage, antepartum and postpartum haemorrhage, and neonatal complications are all increased in individuals presenting with the disease in pregnancy. Some individuals may develop antibodies to platelet glycoproteins; the presence of these antibodies is a rare cause of neonatal alloimmune thrombocytopenia and potential intracranial haemorrhage. Multidisciplinary care is paramount for ensuring optimal fetal and maternal outcomes in such cases. We report a case of neonatal alloimmune thrombocytopenia secondary to maternal Glanzmann thrombasthenia in pregnancy.
Department of Obstetrics and Gynaecology, St George's Hospital, UK.
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Wijemanne
Department of Obstetrics and Gynaecology, St George's Hospital, UK.
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Watt-Coote
Department of Haematology, St George's Hospital, UK.
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Austin
Glanzmann thrombasthenia; High-risk pregnancy; haematology; haemorrhage; maternal-fetal medicine; neonatal alloimmune thrombocytopenia