Pancreatic gastrointestinal stromal tumor: A case report.
BACKGROUND
Gastrointestinal stromal tumors (GISTs) are the most common gastrointestinal tract (GIT) tumors of mesenchymal origin. GISTs tend to arise with a higher frequency in the stomach and the small intestine. GISTs that originate from outside of the GIT are defined as extra-gastrointestinal stromal tumors (EGISTs). Among them pancreatic EGISTs are very rare.


METHODS
A 30 years old male patient presented with abdominal pain. Triphasic abdominal computed tomography scan with contrast revealed large well defined mass at the pancreatic tail, about 12×11.6cm. Laparoscopic distal pancreatectomy and splenectomy was performed. Postoperative pathological examination revealed positive CD 117 and Dog 1 confirming the diagnosis of EGISTs.


CONCLUSIONS
GIST is a rare mesenchymal tumor. EGISTs arising in the pancreas are extremely rare, about, 5% of EGISTs. Its origin remains controversial. Some authors believe that GISTs and EGISTs arise from the common cell origin of interstitial cells of Cajal. Others suggest that EGISTs are at the beginning, mural GISTs with extensive extramural growth, resulting in later on, loss of their connection with the GIT wall.


CONCLUSIONS
We report a rare case of large pancreatic tail EGIST, which was resected, safely and effectively by laparoscopic approach.
Gastroenterology Surgical Center, Mansoura University, Egypt.
Ahmed
A
Elgeidie
Gastroenterology Surgical Center, Mansoura University, Egypt. Electronic address: gec_drelsayedadel86@hotmail.com.
El-Sayed Abou
EA
El-Magd
Pathology Department, Mansoura University, Egypt.
Sara Raafat Abu
SRA
El-Maaty
Pathology Department, Mansoura University, Egypt.
Amira Kamal
AK
El-Hawary