Natural Products as a Source of Antiarrhythmic Drugs.
Throughout the development of medicine, the spotlight has been held by the search for new drugs blocking different types of arrhythmia. In the past decade, much attention was given to the selection of active antiarrhythmic substances from plant material. It has been shown that these compounds have a good antiarrhythmic effect, and their chemical modifications substantially increase their major effects while adding other beneficial pharmacological properties. In this regard, work on the chemical modification of plant-source antiarrhythmics is highly relevant to the development of new and promising drugs.
Novosibirsk Institute of Organic Chemistry, Siberian Branch of Russian Academy of Sciences, 9 Prosp. Akad. Lavrentyeva, Novosibirsk 630090, Russian Federation.
Arkadiy O
AO
Bryzgalov
Novosibirsk Institute of Organic Chemistry, Siberian Branch of Russian Academy of Sciences, 9 Prosp. Akad. Lavrentyeva, Novosibirsk 630090, Russian Federation.
Tatjana G
TG
Tolstikova
Novosibirsk Institute of Organic Chemistry, Siberian Branch of Russian Academy of Sciences, 9 Prosp. Akad. Lavrentyeva, Novosibirsk 630090, Russian Federation.
Elvira E
EE
Shults
Novosibirsk State University, 2 Pirogova, Novosibirsk 630090, Russian Federation.
Kristina O
KO
Petrova
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000737:chemistry / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000188:drug therapy*; D001688:Biological Products / Q000737:chemistry / Q000627:therapeutic use*; D006801:Humans
D000889:Anti-Arrhythmia Agents; D001688:Biological Products
Antiarrhythmic drugs; cardiovascular; chemical modifications; ischemic heart disease; plant substances; thyreoidea