Incidence, prevalence and genetic determinants of neonatal diabetes mellitus: a systematic review and meta-analysis protocol.
In the absence of existing data, the present review intends to determine the incidence, prevalence and/or genetic determinants of neonatal diabetes mellitus (NDM), with expected contribution to disease characterization.



We will include cross-sectional, cohort or case-control studies which have reported the incidence, prevalence and/or genetic determinants of NDM between January 01, 2000 and May 31, 2016, published in English or French languages and without any geographical limitation. PubMed and EMBASE will be extensively screened to identify potentially eligible studies, completed by manual search. Two authors will independently screen, select studies, extract data, and assess the risk of bias; disagreements will be resolved by consensus. Clinical heterogeneity will be investigated by examining the design and setting (including geographic region), procedure used for genetic testing, calculation of incidence or prevalence, and outcomes in each study. Studies found to be clinically homogeneous will be pooled together through a random effects meta-analysis. Statistical heterogeneity will be assessed using the chi-square test of homogeneity and quantified using the I2statistic. In case of substantial heterogeneity, subgroup analyses will be undertaken. Publication bias will be assessed with funnel plots, complemented with the use of Egger's test of bias.



This systematic review and meta-analysis is expected to draw a clear picture of phenotypic and genotypic presentations of NDM in order to better understand the condition and adequately address challenges in respect with its management.



PROSPERO CRD42016039765.
Faculty of Medicine and Biomedical Sciences of the University of Yaoundé I, PO Box 1364, Yaoundé, Cameroon. jobertrichie_nansseu@yahoo.fr.|Mother and Child Centre, Chantal Biya Foundation, Yaoundé, Cameroon. jobertrichie_nansseu@yahoo.fr.
Jobert Richie N
0000-0001-6155-235X
JR
Nansseu
Faculty of Medicine and Biomedical Sciences of the University of Yaoundé I, PO Box 1364, Yaoundé, Cameroon.|Mother and Child Centre, Chantal Biya Foundation, Yaoundé, Cameroon.
Suzanne S
SS
Ngo-Um
National Obesity Centre, Yaoundé Central Hospital, Yaoundé, Cameroon.|Diabetes Research Centre, Vrije Universiteit Brussel-VUB, Laarbeeklaan 103, Brussels, Belgium.|Department of Clinical Chemistry and Radio-immunology, Universitair Ziekenhuis Brussel-UZ Brussel, Vrije Universiteit Brussel, Laarbeeklaan 101, Brussels, Belgium.
Eric V
EV
Balti
D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D003920:Diabetes Mellitus / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D009154:Mutation / Q000235:genetics; D010641:Phenotype; D015995:Prevalence; D000078202:Systematic Reviews as Topic; D015201:Meta-Analysis as Topic
Epidemiology; Genetic: neonatal diabetes mellitus; Meta-analysis; Systematic review