Rhodium catalyzed synthesis of difluoromethyl cyclopropanes.
Difluoromethyl-substituted cyclopropanes still remain one of the most challenging class of substrates. Despite significant progress in modern chemistry, an atom-economic and concise synthesis has not been described to date. Herein, we describe the first method for their catalytic, one-step synthesis using difluoromethyl diazomethane and a rhodium(ii) catalyst.
RWTH Aachen University, Institute of Organic Chemistry, Landoltweg 1, D-52074 Aachen, Germany. rene.koenigs@rwth-aachen.de.
Katharina J
KJ
Hock
Lucas
L
Mertens
Rene M
RM
Koenigs