Step initiation interferes with working memory in nondisabled patients with the earliest multiple sclerosis-A dual-task study.
Balance and cognition are affected by multiple sclerosis (MS). Cognitive-motor interference (CMI) is important for balance impairment in MS, however little is known about CMI at the earliest stages of the disease. Step initiation (SI) with anticipatory postural adjustments (APAs) has been linked to postural instability and falls in subjects with MS, therefore we aimed to assess CMI between SI and the two storage systems of working memory in patients with clinically isolated syndrome (presented as optic neuritis-ON) suggestive of MS. Twenty patients with normal/near normal visual acuity and 20 age-, weight-, height-, sex- and education-matched control subjects were included. APAs were studied using center of pressure measures in three conditions: SI alone, SI+Brooks' spatial- and SI+2-back verbal working memory task. Decrements (% change) in performance on cognitive tasks and in APA parameters were calculated. CMI was assessed combining the two decrements scores. Performance on both cognitive tasks was more affected by dual-tasking in patients compared to healthy subjects. In both groups APA parameters were not influenced by dual-tasking. CMI was higher in patients compared to healthy subjects. Our results suggest that the disease affects CMI in its earliest stages. Since both cognitive tasks were similarly affected by dual-tasking in patients and controls central executive seems to play the major role in CMI between SI and working memory. Patients prioritizing motor over cognitive task for balance maintenance suggests reduced divided attention capacity as a cause of increased CMI in the earliest MS.
Department of Neurology, University Medical Centre Ljubljana, Ljubljana, Slovenia; Laboratory for Gait and Movement Disorders, Department of Neurology, University Medical Centre Ljubljana, Ljubljana, Slovenia. Electronic address: gregor.brecljakob@kclj.si.
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Brecl Jakob
Neurorehabilitation Unit, Department of Neurology, University Medical Centre Ljubljana, Ljubljana, Slovenia. Electronic address: tamara.remsak@kclj.si.
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Remšak
Department of Neurology, University Medical Centre Ljubljana, Ljubljana, Slovenia. Electronic address: sasa.sega@kclj.si.
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Šega Jazbec
Department of Neurology, University Medical Centre Ljubljana, Ljubljana, Slovenia. Electronic address: alenka.horvat@kclj.si.
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Horvat Ledinek
Department of Neurology, University Medical Centre Ljubljana, Ljubljana, Slovenia. Electronic address: uros.rot@kclj.si.
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Rot
D000328:Adult; D016022:Case-Control Studies; D005260:Female; D005684:Gait; D006801:Humans; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology*; D009103:Multiple Sclerosis / Q000503:physiopathology*; D004856:Postural Balance; D011597:Psychomotor Performance; D013647:Task Performance and Analysis; D016138:Walking
Anticipatory postural adjustments; Balance; Clinically isolated syndrome; Cognitive motor interference; Dual-tasking; Working memory