Concentrations of Water-Soluble Vitamins in Blood and Urinary Excretion in Patients with Diabetes Mellitus.
We examined the concentrations of water-soluble vitamins in blood and urinary excretion of 22 patients with type 2 diabetes mellitus (type 2DM) and 20 healthy control participants. Macronutrient and vitamin intakes of type 2DM subjects were measured using a weighed food record method. Control participants consumed a semipurified diet for eight days. Multiple linear regression models were used to determine whether significant differences existed in vitamin concentrations in blood independent of age, sex, and other confounding factors. Concentrations of vitamins B2, B6, C, niacin, and folate in blood were significantly lower in type 2DM subjects than in controls, independent of confounding factors. Renal clearances of vitamins B6, C, niacin, and folate were significantly higher in type 2DM subjects than in controls. In conclusion, concentrations of vitamins B2, B6, C, niacin, and folate in blood were significantly lower in type 2DM subjects than in controls, independent of confounding factors; based on the evidence of increased urinary clearance of these vitamins, the lower levels were likely due to impaired reabsorption processes.
Department of Food Science and Human Nutrition, Faculty of Agriculture, Ryukoku University, Otsu, Shiga Prefecture, Japan.
Hiromi
H
Iwakawa
Department of Food Science and Human Nutrition, Faculty of Agriculture, Ryukoku University, Otsu, Shiga Prefecture, Japan.
Yasuyuki
Y
Nakamura
Department of Nutrition, Faculty of Health and Nutrition, Shubun University, Ichinomiya, Aichi, Japan.
Tomiho
T
Fukui
Department of Nutrition, School of Human Cultures, The University of Shiga Prefecture, Hikone, Shiga, Japan.
Tsutomu
T
Fukuwatari
Department of Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan.
Satoshi
S
Ugi
Department of Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan.
Hiroshi
H
Maegawa
Department of Food Science and Human Nutrition, Faculty of Agriculture, Ryukoku University, Otsu, Shiga Prefecture, Japan.
Yukio
Y
Doi
Department of Nutrition, School of Human Cultures, The University of Shiga Prefecture, Hikone, Shiga, Japan.
Katsumi
K
Shibata
Japanese; blood vitamin concentration; human; type 2 diabetes mellitus; urine vitamin excretions; water-soluble vitamins