Mechanisms and Targets Involved in Dissemination of Ovarian Cancer.
Ovarian carcinoma is associated with the highest death rate of all gynecological tumors. On one hand, its aggressiveness is based on the rapid dissemination of ovarian cancer cells to the peritoneum, the omentum, and organs located in the peritoneal cavity, and on the other hand, on the rapid development of resistance to chemotherapeutic agents. In this review, we focus on the metastatic process of ovarian cancer, which involves dissemination of, homing to and growth of tumor cells in distant organs, and describe promising molecular targets for possible therapeutic intervention. We provide an outline of the interaction of ovarian cancer cells with the microenvironment such as mesothelial cells, adipocytes, fibroblasts, endothelial cells, and other stromal components in the context of approaches for therapeutic interference with dissemination. The targets described in this review are discussed with respect to their validity as drivers of metastasis and to the availability of suitable efficient agents for their blockage, such as small molecules, monoclonal antibodies or antibody conjugates as emerging tools to manage this disease.
Roche Innovation Center Munich, Roche Diagnostics GmbH, Penzberg, Germany.
Ulrich H
UH
Weidle
Roche Innovation Center Basel, F. Hoffmann-LaRoche Ltd., Basel, Switzerland.
Fabian
F
Birzele
Roche Innovation Center Munich, Roche Diagnostics GmbH, Penzberg, Germany.
Gwendlyn
G
Kollmorgen
Roche Innovation Center Munich, Roche Diagnostics GmbH, Penzberg, Germany ruediger.rueger@roche.com.
Rüdiger
R
Rueger
D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D002448:Cell Adhesion / Q000235:genetics; D004847:Epithelial Cells / Q000473:pathology; D005260:Female; D006801:Humans; D058990:Molecular Targeted Therapy; D009361:Neoplasm Invasiveness / Q000235:genetics* / Q000473:pathology; D009362:Neoplasm Metastasis; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000235:genetics* / Q000473:pathology; D010537:Peritoneum / Q000473:pathology; D054852:Small Molecule Libraries / Q000627:therapeutic use
D000911:Antibodies, Monoclonal; D054852:Small Molecule Libraries
Adipocytes; EOC; ascites; epithelial ovarian cancer Penzberg; growth of metastases; homing; mesothelial cells; peritoneal cells; review; therapeutic targets; transcoelomic dissemination