SEROPREVALENCE OF HTLV IN A POPULATION OF HIV1-INFECTED PATIENTS IN MIDWESTERN BRAZIL.
Human T-cell lymphotropic virus (HTLV) may affect the clinical course of human immunodeficiency virus 1 (HIV1). Both infections are common in endemic areas because these viruses share similar routes of transmission. The aim of this study was to estimate the seroprevalence of HTLV1/2 in a population of HIV1-infected patients in the state of Goiás, Midwestern Brazil. Of the 505 studied patients, four (0.79%) were positive for anti-HTLV1/2 by enzyme-linked immunosorbent assay (ELISA), with HTLV1 infection confirmed by line immunoassay (LIA) and polymerase chain reaction (PCR) in all of the ELISA-positive samples. No cases of HTLV2 infection were observed. The prevalence of HTLV1/HIV1 coinfection was 0.79% (4/505; 95% CI: 0.25-2.16). All the coinfected patients reported sexual risk behaviors and only one reported intravenous drug use. Sequencing of the viral long terminal repeat (LTR) region and phylogenetic analysis revealed that the four HTLV1 isolates belonged to the Transcontinental a subgroup of the Cosmopolitan (1a) subtype, the most frequent subgroup detected in Brazil. This study shows a low prevalence of HTLV1/2 in HIV1-infected patients in Midwestern Brazil.
Universidade Federal de Goiás (UFG), Instituto de Patologia Tropical e Saúde Pública. Goiânia, GO, Brasil.
Aline Garcia
AG
Kozlowski
Universidade Federal de Goiás (UFG), Instituto de Patologia Tropical e Saúde Pública. Goiânia, GO, Brasil.
Márcia Alves Dias de
MA
Matos
Universidade Federal de Goiás (UFG), Instituto de Patologia Tropical e Saúde Pública. Goiânia, GO, Brasil.
Megmar Aparecida Dos Santos
MA
Carneiro
Universidade Federal de Goiás (UFG), Faculdade de Enfermagem. Goiânia, GO, Brasil.
Carmen Luci Rodrigues
CL
Lopes
Universidade Federal de Goiás (UFG), Faculdade de Enfermagem. Goiânia, GO, Brasil.
Sheila Araújo
SA
Teles
Fundação Oswaldo Cruz (FIOCRUZ), Instituto Oswaldo Cruz, Rio de Janeiro, RJ, Brasil.
Carolina Paulo
CP
Vicente
Universidade Federal de Goiás (UFG), Instituto de Patologia Tropical e Saúde Pública. Goiânia, GO, Brasil.
Regina Maria Bringel
RM
Martins
D000328:Adult; D001938:Brazil / Q000453:epidemiology; D060085:Coinfection / Q000453:epidemiology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D015658:HIV Infections / Q000453:epidemiology*; D015490:HTLV-I Infections / Q000453:epidemiology*; D015368:Human T-lymphotropic virus 1 / Q000235:genetics / Q000276:immunology; D015367:Human T-lymphotropic virus 2 / Q000235:genetics / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D015995:Prevalence; D016036:Seroepidemiologic Studies; D012959:Socioeconomic Factors