Adhesion GPCR Function in Pulmonary Development and Disease.
Classic G-protein-coupled receptors (GPCRs) control multiple aspects of pulmonary physiology as demonstrated by loss-of-function experiments in mice and pharmacologic targeting of GPCRs for treatment of several pulmonary diseases. Emerging data demonstrate critical roles for members of the adhesion GPCR (aGPCR) family in pulmonary development, homeostasis, and disease. Although this field is still in its infancy, this chapter will review all available data regarding aGPCRs in pulmonary biology, with a particular focus on the aGPCR for which the most substantial data to date exist: Adgrf5.
Novartis Institutes for Biomedical Research, Basel, 4056, Switzerland.
Marie-Gabrielle
MG
Ludwig
Novartis Institutes for Biomedical Research, Basel, 4056, Switzerland.
Klaus
K
Seuwen
Department of Pediatrics, Section of Pulmonary Biology, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA. James.Bridges@cchmc.org.|Division of Pulmonary Biology, Perinatal Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, ML7029, Cincinnati, OH, 45229, USA. James.Bridges@cchmc.org.
James P
JP
Bridges
D000818:Animals; D002448:Cell Adhesion; D002460:Cell Line; D002462:Cell Membrane / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D008168:Lung / Q000254:growth & development / Q000378:metabolism* / Q000473:pathology; D008171:Lung Diseases / Q000235:genetics / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D051379:Mice; D009024:Morphogenesis; D054730:Protein Interaction Domains and Motifs; D043562:Receptors, G-Protein-Coupled / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D014158:Transcription, Genetic
C516038:ADGRF5 protein, human; C577038:Gpr116 protein, mouse; D043562:Receptors, G-Protein-Coupled
Alveolar epithelium; COPD; Lung development; Lung disease; Lung homeostasis; Pulmonary surfactant