Long-term lifestyle interventions in middle-aged and elderly men with nonalcoholic fatty liver disease: a randomized controlled trial.
Nonalcoholic fatty liver disease (NAFLD), a metabolic disorder related to insulin resistance and metabolic syndrome, has become a public health concern. Currently, the principal therapeutic modalities targeting NAFLD are lifestyle interventions. However, the efficacy of long-term lifestyle interventions in managing NAFLD remains largely unexplored. This study aimed to evaluate the efficacy of long-term lifestyle interventions in middle-aged and elderly men with NAFLD. All 280 eligible patients were randomized to the control or test group. Patients in the test group received counseling on diet and exercise from 2 physicians every 3 months via a phone call. Patients in the control group received only counseling in annual checkups without regular intervention. After the 2-year periodic intervention, body weight, abdominal circumference, ALT, TCH, LDL-C and HDL-C decreased in the test group. Specifically, the fatty liver index (FLI) and NAFLD-fibrosis score (NAFLD-FS) reduced markedly in the test group. However, in the control group, there was only a significant decrease in LDL-C, HDL-C and NAFLD-FS (P < 0.001). The liver steatosis grade of the test group decreased significantly, while it increased in the control group. In NAFLD, long-term lifestyle interventions exert an anti-obesity effect and attenuate liver dysfunction and steatosis.
Department of Gastroenterology, Huadong Hospital, Shanghai Medical College, Fudan University, No. 221 Yan'an West Road, Shanghai 200040, P.R. China.|Shanghai Key Laboratory of Clinical Geriatric Medicine, No. 221 Yan'an West Road, Shanghai 200040, P.R. China.
Fangyuan
F
Dong
Shanghai Key Laboratory of Clinical Geriatric Medicine, No. 221 Yan'an West Road, Shanghai 200040, P.R. China.|Research Center on Aging and Medicine, Fudan University, No. 221 Yan'an West Road, Shanghai 200040, P.R. China.
Yan
Y
Zhang
Department of Gastroenterology, Huadong Hospital, Shanghai Medical College, Fudan University, No. 221 Yan'an West Road, Shanghai 200040, P.R. China.|Shanghai Key Laboratory of Clinical Geriatric Medicine, No. 221 Yan'an West Road, Shanghai 200040, P.R. China.|Research Center on Aging and Medicine, Fudan University, No. 221 Yan'an West Road, Shanghai 200040, P.R. China.
Yiqin
Y
Huang
Department of Gastroenterology, Huadong Hospital, Shanghai Medical College, Fudan University, No. 221 Yan'an West Road, Shanghai 200040, P.R. China.
Yiqian
Y
Wang
Department of Gastroenterology, Huadong Hospital, Shanghai Medical College, Fudan University, No. 221 Yan'an West Road, Shanghai 200040, P.R. China.
Gansheng
G
Zhang
Department of Gastroenterology, Huadong Hospital, Shanghai Medical College, Fudan University, No. 221 Yan'an West Road, Shanghai 200040, P.R. China.|Shanghai Key Laboratory of Clinical Geriatric Medicine, No. 221 Yan'an West Road, Shanghai 200040, P.R. China.
Xiaona
X
Hu
Shanghai Key Laboratory of Clinical Geriatric Medicine, No. 221 Yan'an West Road, Shanghai 200040, P.R. China.|Research Center on Aging and Medicine, Fudan University, No. 221 Yan'an West Road, Shanghai 200040, P.R. China.
Jiaofeng
J
Wang
Department of Gastroenterology, Huadong Hospital, Shanghai Medical College, Fudan University, No. 221 Yan'an West Road, Shanghai 200040, P.R. China.|Shanghai Key Laboratory of Clinical Geriatric Medicine, No. 221 Yan'an West Road, Shanghai 200040, P.R. China.|Research Center on Aging and Medicine, Fudan University, No. 221 Yan'an West Road, Shanghai 200040, P.R. China.
Jie
J
Chen
Department of Gastroenterology, Huadong Hospital, Shanghai Medical College, Fudan University, No. 221 Yan'an West Road, Shanghai 200040, P.R. China.|Shanghai Key Laboratory of Clinical Geriatric Medicine, No. 221 Yan'an West Road, Shanghai 200040, P.R. China.|Research Center on Aging and Medicine, Fudan University, No. 221 Yan'an West Road, Shanghai 200040, P.R. China.
Zhijun
Z
Bao
D015438:Health Behavior; D006801:Humans; D008019:Life Style; D008099:Liver / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology; D008297:Male; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease / Q000000981:diagnostic imaging / Q000628:therapy*; D016896:Treatment Outcome