Nanocrystallization: A Unique Approach to Yield Bright Organic Nanocrystals for Biological Applications.
A new bottom-up nanocrystallization method is developed to fabricate highly fluorescent organic nanocrystals in aqueous media using an aggregation-induced emission fluorogen (AIEgen) as an example. The nanocrystallization strategy leads to the fabrication of uniform nanocrystals of 110 ± 10 nm size in aqueous media, which shows over 400% increase in brightness as compared to the amorphous nanoaggregates.
Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Science Drive 4, 117585, Singapore.
S M Ali
SM
Fateminia
State Key Laboratory of Luminescent Materials and Devices, South China University of Technology, Guangzhou, 510640, China.
Zhiming
Z
Wang
Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Biopolis, 138648, Singapore.
Chi Ching
CC
Goh
Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Science Drive 4, 117585, Singapore.
Purnima N
PN
Manghnani
Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Science Drive 4, 117585, Singapore.
Wenbo
W
Wu
Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Science Drive 4, 117585, Singapore.
Duo
D
Mao
Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Biopolis, 138648, Singapore.
Lai Guan
LG
Ng
State Key Laboratory of Luminescent Materials and Devices, South China University of Technology, Guangzhou, 510640, China.
Zujin
Z
Zhao
State Key Laboratory of Luminescent Materials and Devices, South China University of Technology, Guangzhou, 510640, China.|Department of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.
Ben Zhong
BZ
Tang
Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Science Drive 4, 117585, Singapore.|Institute of Materials Research and Engineering, Agency for Science, Technology and Research (A*STAR), 2 Fusionopolis Way, Innovis, 138634, Singapore.
Bin
B
Liu
D053758:Nanoparticles; D014867:Water
D014867:Water
aggregation-induced emission; bioimaging; nanocrystals; organic nanoparticles; stress-induced crystallization