Update on Lupus Nephritis.
SLE is a chronic inflammatory disease that affects the kidneys in about 50% of patients. Lupus nephritis is a major risk factor for overall morbidity and mortality in SLE, and despite potent anti-inflammatory and immunosuppressive therapies still ends in CKD or ESRD for too many patients. This review highlights recent updates in our understanding of disease epidemiology, genetics, pathogenesis, and treatment in an effort to establish a framework for lupus nephritis management that is patient-specific and oriented toward maintaining long-term kidney function in patients with lupus.
Department of Internal Medicine, The Ohio State Wexner Medical Center, Columbus, Ohio.
Salem
S
Almaani
Alexa
A
Meara
Brad H
BH
Rovin
D001706:Biopsy; D018450:Disease Progression; D020022:Genetic Predisposition to Disease; D006801:Humans; D007668:Kidney / Q000473:pathology / Q000503:physiopathology; D007676:Kidney Failure, Chronic / Q000453:epidemiology; D008181:Lupus Nephritis / Q000453:epidemiology / Q000235:genetics / Q000503:physiopathology / Q000628:therapy; D010641:Phenotype; D011237:Predictive Value of Tests; D011379:Prognosis; D012307:Risk Factors
Chronic; Discoid; Epidemiology and outcomes; Lupus Erythematosus; Renal Insufficiency; Systemic; chronic; glomerular disease; glomerulonephritis; humans; immunosuppression; kidney; kidney failure; lupus nephritis; nephritis; risk factors; systemic lupus erythematosus