Furofuran lignan glucosides from the leaves of Vitex negundo var. cannabifolia.
Two new furofuran lignan glucosides, cannabilignin (1) and isocannabilignin (2), together with four known compounds (3-6), were isolated from the leaves of Vitex negundo var. cannabifolia. The structures of the isolates were elucidated by analysis of spectroscopic data. Compound 3 exhibited weak inhibition of nitric oxide production in lipopolysaccharide-stimulated BV-2 microglial cells with IC50value of 69.1 ± 5.8 μM.
a Modern Research Center for Traditional Chinese Medicine , Beijing University of Chinese Medicine , Beijing , People's Republic of China.|b School of Chinese Materia Medica , Beijing University of Chinese Medicine , Beijing , People's Republic of China.
Yue-Ting
YT
Li
a Modern Research Center for Traditional Chinese Medicine , Beijing University of Chinese Medicine , Beijing , People's Republic of China.|b School of Chinese Materia Medica , Beijing University of Chinese Medicine , Beijing , People's Republic of China.
Man-Man
MM
Li
a Modern Research Center for Traditional Chinese Medicine , Beijing University of Chinese Medicine , Beijing , People's Republic of China.|b School of Chinese Materia Medica , Beijing University of Chinese Medicine , Beijing , People's Republic of China.
Jing
J
Sun
a Modern Research Center for Traditional Chinese Medicine , Beijing University of Chinese Medicine , Beijing , People's Republic of China.
Zhi-Xiang
ZX
Zhu
a Modern Research Center for Traditional Chinese Medicine , Beijing University of Chinese Medicine , Beijing , People's Republic of China.
Yue-Lin
YL
Song
a Modern Research Center for Traditional Chinese Medicine , Beijing University of Chinese Medicine , Beijing , People's Republic of China.|b School of Chinese Materia Medica , Beijing University of Chinese Medicine , Beijing , People's Republic of China.
Dao-Ran
DR
Pang
a Modern Research Center for Traditional Chinese Medicine , Beijing University of Chinese Medicine , Beijing , People's Republic of China.
Jiao
J
Zheng
a Modern Research Center for Traditional Chinese Medicine , Beijing University of Chinese Medicine , Beijing , People's Republic of China.
Yun-Fang
YF
Zhao
a Modern Research Center for Traditional Chinese Medicine , Beijing University of Chinese Medicine , Beijing , People's Republic of China.
Peng-Fei
PF
Tu
a Modern Research Center for Traditional Chinese Medicine , Beijing University of Chinese Medicine , Beijing , People's Republic of China.
Jun
J
Li
D000818:Animals; D002460:Cell Line; D004353:Drug Evaluation, Preclinical / Q000379:methods; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D017705:Lignans / Q000737:chemistry* / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000494:pharmacology; D051379:Mice; D017628:Microglia / Q000187:drug effects / Q000378:metabolism; D015394:Molecular Structure; D009569:Nitric Oxide / Q000096:biosynthesis; D018515:Plant Leaves / Q000737:chemistry; D020950:Vitex / Q000737:chemistry*
D005960:Glucosides; D017705:Lignans; D008070:Lipopolysaccharides; C000619393:cannabilignin; D009569:Nitric Oxide
Verbenaceae; Vitex negundo var. cannabifolia; lignan glucoside