Myxoid liposarcoma of the foot: a study of 8 cases.
BACKGROUND
Myxoid liposarcoma is the only translocation-associated liposarcoma subtype. It classically originates in the deep soft tissues of the thigh. At distal sites of the extremities, this tumor is exceedingly rare. We present a series of 8 cases occurring in the foot/ankle.


RESULTS
Two female and 6 male patients, aged between 32 and 77 years (mean, 54.3 years), were identified. Tumor size ranged from 1.1 to 10 cm (mean, 6.8 cm). Two lesions eroded bone. All tumors were treated by excision and 7 by (neo)adjuvant radiotherapy. R0 status was reached in 2 cases with 1 case followed by metastasis in the groin. All other cases were documented with R1 (n=2) or R2 (n=4) resection status. In 1 patient, the follow-up status was unknown. All other patients were alive 15-135 (mean, 55.8) months after initial diagnosis. We conclude that myxoid liposarcoma at acral sites are exceedingly rare, and in this series, prognosis was good irrespective of resection status. Clinicians and pathologists have to be aware because this sarcoma type shows a peculiar clinical behavior with high radio- and chemosensitivity and metastatic spread to extrapulmonary sites.
Department of Pathology, Radboud University Medical Center, Nijmegen, the Netherlands. Electronic address: elise_bekers@hotmail.com.
Elise M
EM
Bekers
Department of Pathology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Wangzhao
W
Song
Department of Pathology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Albert J H
AJ
Suurmeijer
Department of Surgical Oncology, Radboud University Medical Center, Nijmegen, the Netherlands.
Johannes J
JJ
Bonenkamp
Department of Orthopedics, Radboud University Medical Center, Nijmegen, the Netherlands.
Ingrid C
IC
van der Geest
Department of Radiation Oncology, Radboud University Medical Center, Nijmegen, the Netherlands.
Petra M
PM
Braam
Department of Radiology, Radboud University Medical Center, Nijmegen, the Netherlands.
Marieke J M
MJ
Ploegmakers
Department of Medical Oncology, Radboud University Medical Center, Nijmegen, the Netherlands.
Ingrid M E
IM
Desar
Department of Pathology, Radboud University Medical Center, Nijmegen, the Netherlands.
Bastiaan B J
BB
Tops
Department of Pathology, Diakonessenhuis Utrecht, the Netherlands.
Joost M
JM
van Gorp
Department of Pathology, Ghent University Hospital, Ghent, Belgium.
David H
DH
Creytens
Dermatopathology Bodensee, Friedrichshafen, Germany.
Thomas
T
Mentzel
Department of Pathology, Radboud University Medical Center, Nijmegen, the Netherlands.
Uta
U
Flucke
D000328:Adult; D000368:Aged; D005260:Female; D005528:Foot / Q000473:pathology*; D006801:Humans; D018208:Liposarcoma, Myxoid / Q000175:diagnosis* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis* / Q000473:pathology*; D011379:Prognosis; D012509:Sarcoma / Q000175:diagnosis / Q000473:pathology*; D013848:Thigh / Q000473:pathology; D014178:Translocation, Genetic / Q000502:physiology
Acral site; Ankle; EWSR1 rearrangement; FUS rearrangement; Foot; Myxoid liposarcoma