5'-AMP-Activated Protein Kinase Signaling in Caenorhabditis elegans.
AMP-activated protein kinase (AMPK) is one of the central regulators of cellular and organismal metabolism in eukaryotes. Once activated by decreased energy levels, it induces ATP production by promoting catabolic pathways while conserving ATP by inhibiting anabolic pathways. AMPK plays a crucial role in various aspects of cellular function such as regulating growth, reprogramming metabolism, autophagy, and cell polarity. In this chapter, we focus on how recent breakthroughs made using the model organism Caenorhabditis elegans have contributed to our understanding of AMPK function and how it can be utilized in the future to elucidate hitherto unknown aspects of AMPK signaling.
Department of Biology, McGill University, 1205 Avenue Docteur Penfield, Montreal, QC, Canada, H3A 1B1.
Moloud
M
Ahmadi
Department of Biology, McGill University, 1205 Avenue Docteur Penfield, Montreal, QC, Canada, H3A 1B1. richard.roy@mcgill.ca.
Richard
R
Roy
D055372:AMP-Activated Protein Kinases / Q000235:genetics* / Q000378:metabolism; D000818:Animals; D001343:Autophagy / Q000235:genetics; D017173:Caenorhabditis elegans / Q000235:genetics* / Q000378:metabolism; D029742:Caenorhabditis elegans Proteins / Q000235:genetics / Q000378:metabolism; D031204:Caloric Restriction; D051858:Forkhead Transcription Factors / Q000235:genetics / Q000378:metabolism; D005786:Gene Expression Regulation; D006066:Gonads / Q000378:metabolism; D007328:Insulin / Q000235:genetics / Q000378:metabolism; D007334:Insulin-Like Growth Factor I / Q000235:genetics / Q000378:metabolism; D050356:Lipid Metabolism / Q000235:genetics; D008136:Longevity / Q000235:genetics*; D008928:Mitochondria / Q000235:genetics / Q000378:metabolism; D021122:Protein Subunits / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction / Q000235:genetics*; D058570:TOR Serine-Threonine Kinases / Q000235:genetics / Q000378:metabolism
D029742:Caenorhabditis elegans Proteins; D051858:Forkhead Transcription Factors; D007328:Insulin; D021122:Protein Subunits; C108831:daf-16 protein, C elegans; D007334:Insulin-Like Growth Factor I; D058570:TOR Serine-Threonine Kinases; D055372:AMP-Activated Protein Kinases
AAK-2; AMPK; Caenorhabditis elegans; Dauer; Diapause; Germline stem cell quiescence; Lifespan; Longevity