The association between oxidized low-density lipoprotein antibodies and hematological diseases.
BACKGROUND
The aim of the study is to compare the profiles of antibodies (IgM and IgG) against oxidized low-density lipoprotein (oxLDL) of hematological diseases.


METHODS
The serum antibodies of oxLDL-IgM and oxLDL-IgG for 446 cases with hematological diseases and 90 patients with primary hypertension and 90 healthy controls were measured by enzyme-linked immunosorbent assay (ELISA) in a cross-section survey. The association of serum oxLDL-LgM and oxLDL-IgG with hematological diseases was analyzed by multiple linear regression model.


RESULTS
Comparing with the hypertension or normal groups, the levels of TCH, TG, LDL-c, HDL-c, oxLDL, and oxLDL-IgG were lower and the levels of ADP and oxLDL-IgM were higher in the hematological diseases group. The levels of oxLDL-IgG antibodies titer were different among hematological diseases group. The results of correlation and multiple regression analysis showed that the seven hematological disease subgroups were positively related to the oxLDL-IgM antibody titer but negatively related to the oxLDL-IgG antibody titer, having been adjusted for potential confounding factors such as age, SBP, DBP, BMI, TCH, TG, ADP, oxLDL, HDL-c, LDL-C.


CONCLUSIONS
Here we show that oxLDL-IgG antibodies titer were lower and of oxLDL-IgM titer were higher than hypertension and healthy individuals. Also oxLDL-IgG titer were different among hematological diseases group.
Department of Hematology, Qilu Hospital, Shandong University, Jinan, 250012, China.
Hao
H
Li
The Key Laboratory of Cardiovascular Remodelling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Department of Cardiology, Qilu Hospital, Shandong University, 107# Wenhuaxi Road, Jinan, 250012, China. qingdali611@163.com.
Da-Qing
DQ
Li
Department of Hematology, Qilu Hospital, Shandong University, Jinan, 250012, China.
Xiang-Xin
XX
Li
Department of Hematology, Qilu Hospital, Shandong University, Jinan, 250012, China.
Lu-Qun
LQ
Wang
D000328:Adult; D000368:Aged; D000906:Antibodies / Q000097:blood* / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D000075222:Essential Hypertension; D005260:Female; D064368:Healthy Volunteers; D006402:Hematologic Diseases / Q000097:blood* / Q000276:immunology; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000276:immunology; D007074:Immunoglobulin G / Q000097:blood / Q000302:isolation & purification; D007075:Immunoglobulin M / Q000097:blood / Q000302:isolation & purification; D008077:Lipoproteins, LDL / Q000097:blood* / Q000276:immunology; D008297:Male; D008875:Middle Aged
D000906:Antibodies; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein
Autoantibody; Hematological diseases; Oxidized low-density lipoprotein; oxLDL-IgG antibody; oxLDL-IgM antibody