Small Intestinal Submucosa Grafting for Peyronie Disease: Outcomes and Patient Satisfaction.
OBJECTIVE
To evaluate surgical outcomes and complications and assess overall patient satisfaction after small intestinal submucosa (SIS) grafting for Peyronie disease.


METHODS
Twenty-eight patients were treated with tunical incision and grafting with SIS. Mean age of the patients was 58 (range: 43-71) years. A preoperative protocol was applied to all patients. Patients were also evaluated at follow-up clinic visits. The International Index of Erectile Function, a modified Erectile Dysfunction Inventory of Treatment Satisfaction questionnaire, postoperative self-reports, and clinical characteristics were used to measure outcomes.


RESULTS
Hypertension, hypercholesterolemia, and type 2 diabetes were reported in 53,6%, 46,4%, and 28,6% of patients, respectively. Previous penile trauma was reported by 10,7%. The mean operative time was 151 ± 23 minutes. Average follow-up was 18 months (range: 3-36). The only surgical complication was 1 case of infected hematoma treated with surgical drainage. Self-reported complete resolution of curvature was 82,1%. Subjective perception of penile shortening was reported by 71,4% of patients. However, only 4 patients objectively showed postoperative penile shortening. Erectile function was completely preserved in 64,2%. Four patients complained of erectile dysfunction despite medication, even though no objective vascular etiology was shown on postoperative penile Doppler ultrasound. Overall, 82,2% of patients reported high levels of satisfaction.


CONCLUSIONS
Surgical treatment of Peyronie disease using SIS grafting is a safe option, with low rate of major complications. It has good surgical outcomes and high patient satisfaction rates.
Department of Renal, Urological and Infectious Diseases, Centro Hospitalar de São João, Porto, Portugal; Department of Urology, Centro Hospitalar do Tâmega e Sousa, Penafiel, Portugal. Electronic address: pedrovalente.md@gmail.com.
Pedro
P
Valente
Faculty of Medicine, University of Porto, Porto, Portugal.
Carolina
C
Gomes
Department of Renal, Urological and Infectious Diseases, Centro Hospitalar de São João, Porto, Portugal; Faculty of Medicine, University of Porto, Porto, Portugal.
Nuno
N
Tomada
D000328:Adult; D000368:Aged; D000818:Animals; D015331:Cohort Studies; D006801:Humans; D007421:Intestine, Small / Q000637:transplantation*; D008297:Male; D008875:Middle Aged; D061646:Operative Time; D017060:Patient Satisfaction; D010410:Penile Erection; D010411:Penile Induration / Q000601:surgery*; D019651:Plastic Surgery Procedures; D013552:Swine; D014183:Transplantation, Heterologous; D016896:Treatment Outcome