The impact of gastric bypass surgery on sex hormones and menstrual cycles in premenopausal women.
Obesity has adverse effects on ovulation, menstrual cyclicity and oocyte development leading to clinical symptoms such as infertility and menstrual disorders. The Roux-en-Y gastric bypass (RYGB) leads to weight loss, improved insulin sensitivity and may improve ovarian function. In 31 premenopausal women, 18 eu- and 13 oligo-/amenorrhoic, we followed the changes in follicular phase sex hormones 3, 6 and 12 month after RYGB. The average weight loss during the first postoperative year was 39.6 kg. The insulin sensitivity and serum insulin improved markedly especially within the first three postoperative months. SHBG increased progressively and was doubled after 12 months. In contrast, total and free androgens and DHEA declined about 50% during the first three postoperative months and remained fairly constant hereafter. One year after surgery, 85% (11/13) of the women with oligo-/amenorrhea gained regular menstrual cycles. Our results indicate that some of the endocrine changes related to regulation of ovarian function occur very early after bariatric surgery.
a Department of Obstetrics and Gynecology , Hvidovre University Hospital , Denmark.
Mette Mandrup
MM
Kjær
b Department of Endocrinology , Hvidovre University Hospital , Denmark , and.
Sten
S
Madsbad
c Department for Congenital Disorders , Statens Serums Institute , Denmark.
David M
DM
Hougaard
c Department for Congenital Disorders , Statens Serums Institute , Denmark.
Arieh S
AS
Cohen
a Department of Obstetrics and Gynecology , Hvidovre University Hospital , Denmark.
Lisbeth
L
Nilas
D000328:Adult; D000568:Amenorrhea / Q000097:blood* / Q000209:etiology; D005260:Female; D005498:Follicular Phase / Q000097:blood*; D005500:Follow-Up Studies; D015390:Gastric Bypass; D012739:Gonadal Steroid Hormones / Q000097:blood*; D006801:Humans; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000150:complications / Q000601:surgery; D009839:Oligomenorrhea / Q000097:blood* / Q000209:etiology; D017063:Outcome Assessment, Health Care; D017697:Premenopause / Q000097:blood*; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism*; D055815:Young Adult
D012739:Gonadal Steroid Hormones; D012738:Sex Hormone-Binding Globulin
Insulin sensitivity; PCOS; RYGB; menstrual cyclicity; sex hormones; weight loss