Emergency LP in a patient receiving dabigatran after antagonization with idarucizumab.
Idarucizumab is an antibody fragment which is used to reverse the anticoagulant effects of dabigatran. We report on the first successful use of idarucizumab before performing an emergency lumbar puncture in a patient on effective anticoagulation with dabigatran thought to have infective cerebral disease (such as temporal encephalitis).
Department of Neurology, Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany; Berlin Institute of Health (BIH), Berlin, Germany. Electronic address: tim-bastian.braemswig@charite.de.
Tim Bastian
TB
Braemswig
Boehringer Ingelheim Pharma GmbH & Co. KG, Medical Affairs Germany, Binger Straße 173, 55216 Ingelheim am Rhein, Germany.
Christoph C
CC
Eschenfelder
Department of Neurology, Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany; Berlin Institute of Health (BIH), Berlin, Germany.
Christian H
CH
Nolte
D000369:Aged, 80 and over; D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use*; D000931:Antidotes / Q000627:therapeutic use*; D000991:Antithrombins / Q000627:therapeutic use*; D001037:Aphasia / Q000134:cerebrospinal fluid / Q000175:diagnosis* / Q000209:etiology; D001281:Atrial Fibrillation / Q000188:drug therapy; D016893:Carotid Stenosis / Q000150:complications / Q000000981:diagnostic imaging / Q000601:surgery; D000069604:Dabigatran / Q000627:therapeutic use*; D004630:Emergencies; D004636:Emergency Service, Hospital; D016894:Endarterectomy, Carotid; D006470:Hemorrhage / Q000517:prevention & control*; D006801:Humans; D020244:Infarction, Middle Cerebral Artery / Q000134:cerebrospinal fluid / Q000150:complications / Q000000981:diagnostic imaging*; D008279:Magnetic Resonance Imaging; D008297:Male; D013129:Spinal Puncture / Q000379:methods*; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography
D061067:Antibodies, Monoclonal, Humanized; D000931:Antidotes; D000991:Antithrombins; C000594745:idarucizumab; D000069604:Dabigatran