Expression of co-stimulatory molecules CD80 and CD86 is altered in CD14 + HLA-DR + monocytes from patients with Chagas disease following induction by Trypanosoma cruzi recombinant antigens.
BACKGROUND
The relationships between monocytes and lymphocytes through MHC class II molecules and costimulatory, are of utmost importance for the production of an efficient immune response. In this work, we assessed the expression of surface molecules CD80 and CD86 on CD14+HLA-DR+ monocytes from patients with Chagas disease.
The study population consisted of 31 patients with chronic clinical forms of Chagas disease. Patient blood samples were cultured in the presence of recombinant cytoplasmic repetitive antigen (CRA) and flagellar repetitive antigen (FRA).
We found considerable differences in the expression profile of surface molecules involved in antigen presentation.
CRA and FRA may contribute to host immune response evasion by Trypanozoma cruzi.
Centro de Pesquisas Aggeu Magalhães, Fundação Oswaldo Cruz, Recife, Pernambuco, Brazil.
Ana Karine de Araújo
AK
Soares
Centro de Pesquisas Aggeu Magalhães, Fundação Oswaldo Cruz, Recife, Pernambuco, Brazil.
Patrícia Areias Feitosa
PA
Neves
Pronto-Socorro Cardiológico de Pernambuco (PROCAPE) - Universidade de Pernambuco, Recife Pernambuco, Brazil.|Programa Integrado de Doença de Chagas, Fundação Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro, Brazil.
Maria da Glória Aureliano de Melo
MD
Cavalcanti
Pronto-Socorro Cardiológico de Pernambuco (PROCAPE) - Universidade de Pernambuco, Recife Pernambuco, Brazil.|Programa Integrado de Doença de Chagas, Fundação Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro, Brazil.
Sílvia Martins
SM
Marinho
Pronto-Socorro Cardiológico de Pernambuco (PROCAPE) - Universidade de Pernambuco, Recife Pernambuco, Brazil.|Programa Integrado de Doença de Chagas, Fundação Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro, Brazil.
Wilson de
W
Oliveira
Departamento de Fisiologia e Patologia, Universidade Federal da Paraíba, João Pessoa, Paraíba, Brazil.
Joelma Rodrigues de
JR
Souza
Centro de Pesquisas Aggeu Magalhães, Fundação Oswaldo Cruz, Recife, Pernambuco, Brazil.|Programa Integrado de Doença de Chagas, Fundação Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro, Brazil.
Virginia Maria Barros de
VM
Lorena
Centro de Pesquisas Aggeu Magalhães, Fundação Oswaldo Cruz, Recife, Pernambuco, Brazil.|Programa Integrado de Doença de Chagas, Fundação Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro, Brazil.
Yara de Miranda
YM
Gomes
D000953:Antigens, Protozoan / Q000276:immunology*; D018122:B7-1 Antigen / Q000276:immunology; D051940:B7-2 Antigen / Q000276:immunology; D002478:Cells, Cultured; D014355:Chagas Disease / Q000276:immunology*; D002908:Chronic Disease; D006684:HLA-DR Antigens / Q000276:immunology; D006801:Humans; D018950:Lipopolysaccharide Receptors / Q000276:immunology; D009000:Monocytes / Q000276:immunology* / Q000469:parasitology; D011994:Recombinant Proteins / Q000276:immunology
D000953:Antigens, Protozoan; D018122:B7-1 Antigen; D051940:B7-2 Antigen; D006684:HLA-DR Antigens; D018950:Lipopolysaccharide Receptors; D011994:Recombinant Proteins