Expression Data Analysis for the Identification of Potential Biomarker of Pregnancy Associated Breast Cancer.
Breast cancer affects every 1 of 3000 pregnant women or in the first post-partum year is referred as Pregnancy Associated Breast Cancer (PABC) in mid 30s. Even-though rare disease, classified under hormone receptor negative status which metastasis quickly to other parts by extra cellular matrix degradation. Hence it is important to find an optimal treatment option for a PABC patient. Also additional care should be taken to choose the drug; in order to avoid fetal malformation and post-partum stage side-effects. The adaptation of target based therapy in the clinical practice may help to substitute the mastectomy treatment. Recent studies suggested that certain altered Post Translational Modifications (PTMs) may be an indicative of breast cancer progression; an attempt is made to consider the over represented PTM as a parameter for gene selection. The public dataset of PABC from GEO were examined to select Differentially Expressed Genes (DEG). The corresponding PTMs for DEG were collected and association between them was found using data mining technique. Usually clustering algorithm has been applied for the study of gene expression with drawback of clustering of gene products based on specified features. But association rule mining method overcome this shortcoming and determines the useful and in depth relationships. From the association, genes were selected to study the interactions and pathways. These studies emphasis that the genes KLF12, FEN1 MUC1 and SP110, can be chosen as target, which control cancer development, without any harm to pregnancy as well as fetal developmental process.
Centre for Bioinformatics, Pondicherry University, Puducherry, 605014, India.
Raja Rajeswary
RR
Thanmalagan
Centre for Bioinformatics, Pondicherry University, Puducherry, 605014, India.
Leimarembi Devi
LD
Naorem
Centre for Bioinformatics, Pondicherry University, Puducherry, 605014, India. amouda@bicpu.edu.in.
Amouda
A
Venkatesan
D014408:Biomarkers, Tumor / Q000235:genetics*; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology; D005260:Female; D006801:Humans; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000235:genetics* / Q000473:pathology; D011499:Protein Processing, Post-Translational / Q000235:genetics; D013223:Statistics as Topic
D014408:Biomarkers, Tumor
Association rule mining; Network analysis; PTM; Pregnancy-associated breast cancer