Lipoxin A4(LXA4) as a potential first trimester biochemical marker of intrauterine growth disorders.
OBJECTIVE
To evaluate first trimester maternal serum levels of lipoxin A4(LXA4) in prediction of intrauterine fetal growth.


METHODS
Study group of 185 patients in singleton pregnancy was divided into three subgroups according to neonatal birthweight: ≤10th percentile (SGA), 11-89th percentile (AGA) and ≥90 percentile (LGA).


RESULTS
We observed decreased values of LXA4concentrations, both in SGA- and LGA groups, when compared to AGA (68.91 ± 33.72 and 68.30 ± 23.49 versus 102.13 ± 121.90, respectively).


CONCLUSIONS
Lipoxin A4may become an biochemical marker in the prediction of intrauterine fetal growth disturbances; however, more studies need to be undertaken to investigate LXA4's role in pregnancy.
a 1st Department of Obstetrics and Gynecology and.
Michał
M
Lipa
a 1st Department of Obstetrics and Gynecology and.
Dorota
D
Bomba-Opoń
a 1st Department of Obstetrics and Gynecology and.
Jacek
J
Lipa
a 1st Department of Obstetrics and Gynecology and.
Paweł
P
Bartnik
b Department of Internal Medicine and Endocrinology of Medical University of Warsaw , Poland.
Zbigniew
Z
Bartoszewicz
a 1st Department of Obstetrics and Gynecology and.
Mirosław
M
Wielgoś
D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D005317:Fetal Growth Retardation / Q000097:blood*; D006801:Humans; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age; D044045:Lipoxins / Q000097:blood*; D011247:Pregnancy; D011261:Pregnancy Trimester, First / Q000097:blood
D015415:Biomarkers; D044045:Lipoxins; C040527:lipoxin A4
AGA; IUGR; LGA; SGA; macrosomia