Association between microRNA polymorphisms and coronary heart disease : A meta-analysis.
The association between microRNA polymorphisms (miR polymorphisms) and coronary heart disease (CHD) risk has been studied intensively, but the results have been conflicting. Therefore, we conducted the present meta-analysis to obtain a more conclusive answer. We searched for eligible articles in PubMed, MEDLINE, EMBASE, Scopus, and CNKI. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to identify any potential associations. Ten case-control studies including 5,292 CHD patients and 5,446 control subjects were analyzed. The overall meta-analysis results showed that the miR-146a rs2910164 polymorphism, the miR-196a2 rs11614913 polymorphism, and the miR-499 rs3746444 polymorphism were all significantly associated with CHD risk in certain genetic models. Besides, the C allele of the miR-146a rs2910164 and miR-499 rs3746444 polymorphisms conferred increased susceptibility to CHD (C versus G, p < 0.0001, OR = 1.14, 95% CI = 1.07-1.21; p = 0.003, OR = 1.14, 95% CI = 1.05-1.25). Overall, our findings suggest that the miR-146a rs2910164, miR-196a2 rs11614913, and miR-499 rs3746444 polymorphisms may be correlated with the risk of CHD.
Department of Cardiology, West China Hospital, Sichuan University, 610041, Chengdu, Sichuan, China.
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Xie
Division of Reproductive Medical Center, West China Second University Hospital, Sichuan University, 610041, Chengdu, Sichuan, China.
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Shi
West China School of Public Health, Sichuan University, 610041, Chengdu, Sichuan, China.
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Xun
Department of Cardiology, West China Hospital, Sichuan University, 610041, Chengdu, Sichuan, China. raoli8991@163.com.
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Rao
D000483:Alleles; D016022:Case-Control Studies; D003327:Coronary Disease / Q000235:genetics*; D000078331:Correlation of Data; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D016017:Odds Ratio; D011110:Polymorphism, Genetic / Q000235:genetics*; D012306:Risk
D035683:MicroRNAs
Coronary disease; Meta-analysis; MicroRNA; Polymorphism, genetic; Relative risk