Enhancing Stent Effectiveness with Nanofeatures.
Drug-eluting stents are an effective therapy for symptomatic arterial obstructions, substantially reducing the incidence of restenosis by suppressing the migration and proliferation of vascular smooth muscle cells into the intima. However, current drug-eluting stents also inhibit the growth of endothelial cells, which are required to cover the vascular stent to reduce an excessive inflammatory response. As a result, the endothelial lining of the lumen is not regenerated. Since the loss of this homeostatic monolayer increases the risk of thrombosis, patients with drug-eluting stents require long-term antithrombotic therapy. Thus, there is a need for improved devices with enhanced effectiveness and physiological compatibility towards endothelial cells. Current developments in nanomaterials may enhance the function of commercially available vascular devices. In particular, modified design schemes might incorporate nanopatterns or nanoparticle-eluting features that reduce restenosis and enhance re-endothelialization. The intent of this review is to discuss emerging nanotechnologies that will improve the performance of vascular stents.
Northeastern University, Boston, Massachusetts.
Nicole
N
Bassous
Houston Methodist Research Institute, Houston, Texas.
John P
JP
Cooke
Northeastern University, Boston, Massachusetts.
Thomas J
TJ
Webster
D054059:Coronary Occlusion / Q000601:surgery*; D023903:Coronary Restenosis / Q000517:prevention & control*; D054855:Drug-Eluting Stents; D006801:Humans; D053758:Nanoparticles
bare-metal stents; drug-eluting stents; nanoparticle-eluting stents; nanopatterning; nanotechnology