The effect of a lipid composition and a surfactant on the characteristics of the solid lipid microspheres and nanospheres (SLM and SLN).
Solid lipid microparticles (SLM) were produced by a two-step process that, firstly, involved the emulsification of the molten lipid phase in a heated aqueous phase and, secondly, the system cooling. Compritol 888 ATO and Precirol ATO 5, including their mixtures with Miglyol 812 or Witepsol H15 were used as lipid components (10-30% w/w). The average size of the SLM prepared with Compritol and Tween 80 as an emulsifier was 3-7μm and the influence of lipid concentration and thermal sterilization was not large. Dispersions of SLM with Precirol (10-20% w/w) gellified upon storage. SLM stabilized with another surfactant, Tego Care 450, were larger in size and measured 40μm on average. The use of the sonication step (5-15min) in hot formulations containing 5% w/w of Compritol resulted in the formation of the solid lipid nanoparticles (SLN) with average size 200-300nm. The smallest SLN size (below 100nm on average) was obtained in SLN that contained Tego Care and an antimicrobial agent Euxyl PE 9010; such combination evoked synergism between the surfactant and Euxyl components.
Medical University of Gdansk, Department of Pharmaceutical Technology, Al. Gen. J. Hallera 107, 80-416 Gdansk, Poland. Electronic address: msznito@gumed.edu.pl.
Malgorzata
M
Sznitowska
Medical University of Gdansk, Department of Pharmaceutical Technology, Al. Gen. J. Hallera 107, 80-416 Gdansk, Poland.
Eliza
E
Wolska
Medical University of Gdansk, Department of Pharmaceutical Technology, Al. Gen. J. Hallera 107, 80-416 Gdansk, Poland.
Helena
H
Baranska
Medical University of Gdansk, Department of Pharmaceutical Technology, Al. Gen. J. Hallera 107, 80-416 Gdansk, Poland.
Krzysztof
K
Cal
Medical University of Gdansk, Department of Pharmaceutical Technology, Al. Gen. J. Hallera 107, 80-416 Gdansk, Poland.
Justyna
J
Pietkiewicz
D001696:Biomechanical Phenomena; D004075:Diglycerides / Q000737:chemistry; D005227:Fatty Acids / Q000737:chemistry; D006358:Hot Temperature; D008055:Lipids / Q000737:chemistry*; D008853:Microscopy; D008863:Microspheres; D053758:Nanoparticles / Q000737:chemistry; D054118:Nanospheres / Q000737:chemistry*; D010316:Particle Size; D011136:Polysorbates / Q000737:chemistry; D011312:Pressure; D011663:Pulmonary Surfactants / Q000737:chemistry; D013501:Surface-Active Agents / Q000737:chemistry*; D014280:Triglycerides / Q000737:chemistry; D014783:Viscosity
D004075:Diglycerides; D005227:Fatty Acids; D008055:Lipids; D011136:Polysorbates; D011663:Pulmonary Surfactants; D013501:Surface-Active Agents; D014280:Triglycerides; C009683:witepsol; C086409:glyceryl behenate; C022834:miglyol 812; C009032:precirol
Lipids; Microparticles; Solid lipid nanoparticles; Surfactants; Ultrasound