Electroporation in veterinary oncology.
Cancer treatments in veterinary medicine continue to evolve beyond the established standard therapies of surgery, chemotherapy and radiation therapy. New technologies in cancer therapy include a targeted mechanism to open the cell membrane based on electroporation, driving therapeutic agents, such as chemotherapy (electro-chemotherapy), for local control of cancer, or delivery of gene-based products (electro-gene therapy), directly into the cancer cell to achieve systemic control. This review examines electrochemotherapy and electro-gene therapy in veterinary medicine and considers future directions and applications.
Veterinary Oncology Services, Hopewell Junction, New York 12533, USA.
J
J
Impellizeri
Takis Biotech, 00128 Rome, Italy.
L
L
Aurisicchio
Cork Cancer Research Centre, University College Cork, Ireland.
P
P
Forde
Cork Cancer Research Centre, University College Cork, Ireland. Electronic address: decsoden@gmail.com.
D M
DM
Soden
D000818:Animals; D053672:Electrochemotherapy / Q000662:veterinary; D018274:Electroporation / Q000662:veterinary*; D015316:Genetic Therapy / Q000662:veterinary*; D009369:Neoplasms / Q000628:therapy / Q000662:veterinary*
DNA vaccines; Electro-gene therapy; Electrochemotherapy; Electroporation; Immunotherapy; Veterinary oncology