Regulation of Gene Expression by Exercise-Related Micrornas.
Gene expression control by microRNAs (miRs) is an important mechanism for maintenance of cellular homeostasis in physiological and pathological conditions as well as in response to different stimuli including nutritional factors and exercise. MiRs are involved in regulation of several processes such as growth and development, fuel metabolism, insulin secretion, immune function, miocardium remodeling, cell proliferation, differenciation, survival, and death. These molecules have also been proposed to be potential biomarkers and/or therapeutical targets in obesity, type 2 diabetes mellitus, cardiovascular diseases, metabolic syndrome, and cancer. MiRs are released by most cells and potentially act on intercellular communication to borderer or distant cells. Various studies have been performed to elucidate the involvement of miRs in exercise-induced effects. The aims of this review are: 1) to bring up the main advances for the comprehension of the mechanisms of action of miRs; 2) to present the main results on miR involvement in physical exercise; 3) to discuss the physiological effects of miRs modified by exercise. The state of the art and the perspectives on miRs associated with physical exercise will be presented. Thus, this review is important for updating recent advances and driving further strategies and studies on the exercise-related miR research.
Institute of Physical Activity Sciences and Sports, Cruzeiro do Sul University, Sao Paulo, SP, Brazil.
Laureane Nunes
LN
Masi
Tamires Duarte Afonso
TD
Serdan
Adriana Cristina
AC
Levada-Pires
Elaine
E
Hatanaka
Leonardo Dos Reis
LD
Silveira
Maria Fernanda
MF
Cury-Boaventura
Tania Cristina
TC
Pithon-Curi
Rui
R
Curi
Renata
R
Gorjão
Sandro Massao
SM
Hirabara
D006332:Cardiomegaly / Q000235:genetics; D015444:Exercise / Q000502:physiology*; D005786:Gene Expression Regulation; D006801:Humans; D007109:Immunity / Q000235:genetics; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D010807:Physical Endurance
D035683:MicroRNAs