Subsequent vitiligo after hematopoietic stem cell transplantation: A nationwide population-based cohort study from Korea.
BACKGROUND
Subsequent vitiligo after hematopoietic stem cell transplantation (HSCT) has been described sporadically in case series.


OBJECTIVE
To investigate the incidence and risk factors of subsequent vitiligo after HSCT.


METHODS
A nationwide, population-based cohort study was performed using the Korean National Health Insurance Claims Database from 2009 to 2013. All HSCT recipients who had undergone HSCT between 2010 and 2011 and not treatment for vitiligo in 2009 (to exclude preexisting active vitiligo) were included in the HSCT recipient group, and an age- and sex-matched control group without HSCT was also established.


RESULTS
A total of 2747 HSCT recipients and 8241 controls were enrolled. Newly acquired vitiligo occurred in 1.06% of HSCT recipients between 2010 and 2013, and there was a significant increase (OR 3.130, 95% CI 1.859-5.271) in cases of vitiligo in HSCT recipients compared with controls (0.34%). Allogeneic HSCT (OR 5.593, 95% CI 1.628-19.213) and bone marrow-sourced stem cells (as compared with peripheral blood-sourced stem cells; OR 2.492, 95% CI 1.114-5.576) were independently associated with the development of vitiligo after HSCT.


CONCLUSIONS
Medical record review was not available.


CONCLUSIONS
Vitiligo developed at a significantly increased rate after HSCT compared with controls. Allogeneic HSCT and bone marrow-sourced stem cells were independent risk factors.
Department of Dermatology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Jung Min
JM
Bae
Department of Dermatology, Veterans Health Service Medical Center, Seoul, Korea.
Kwang Hyun
KH
Choi
Department of Dermatology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Han Mi
HM
Jung
Seoul Women's College of Nursing, Seoul, Korea.
Sook Young
SY
Kim
Department of Dermatology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Miri
M
Kim
Department of Dermatology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Gyung Moon
GM
Kim
Department of Dermatology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Dong Soo
DS
Yu
Department of Dermatology, College of Medicine, The Catholic University of Korea, Seoul, Korea. Electronic address: lyb80@catholic.ac.kr.
Young Bok
YB
Lee
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001854:Bone Marrow Cells; D002648:Child; D002675:Child, Preschool; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects / Q000706:statistics & numerical data*; D006801:Humans; D015994:Incidence; D007223:Infant; D008297:Male; D008875:Middle Aged; D056910:Republic of Korea; D012189:Retrospective Studies; D012307:Risk Factors; D014184:Transplantation, Homologous / Q000009:adverse effects / Q000706:statistics & numerical data; D014820:Vitiligo / Q000453:epidemiology* / Q000209:etiology; D055815:Young Adult
hematopoietic stem cell transplantation; incidence; leukemia; nationwide population study; vitiligo