Synthesis of Gallic-Acid-1-Phenyl-1H-[1,2,3]Triazol-4-yl Methyl Esters as Effective Antioxidants.
Using a click chemistry approach, a series of gallic-acid-1-phenyl-1H-[1,2,3]triazol-4-ylmethyl esters was synthesized to develop more effective antioxidants. The results of DPPH screening indicate that few of the synthesized analogs display better antioxidant effect compared to the standards. Among all, compounds,9and20displayed highest DPPH radical scavenging effect with IC50values as low as 6.4±0.2 and 7.9±0.4 µM respectively, compared to the standard ascorbic acid (IC50=12±0.8 µM) and gallic acid (IC50=9.0±0.6 µM). Compound10also displayed a potent antioxidant effect with IC50of 10.80±0.4 µM. This study provides an important aspect with regard to the use of these gallic-acid based synthetic antioxidants in food industry as dietary supplements.
Bioorganic Chemistry Division, Indian Institute of Integrative Medicine (CSIR), Srinagar, Jammu and Kashmir, India.
Shabir H
SH
Lone
Bioorganic Chemistry Division, Indian Institute of Integrative Medicine (CSIR), Srinagar, Jammu and Kashmir, India.
Shakeel U
SU
Rehman
Bioorganic Chemistry Division, Indian Institute of Integrative Medicine (CSIR), Srinagar, Jammu and Kashmir, India.
Khursheed A
KA
Bhat
D001205:Ascorbic Acid / Q000494:pharmacology; D001713:Biphenyl Compounds / Q000378:metabolism*; D019587:Dietary Supplements; D004952:Esters / Q000138:chemical synthesis* / Q000494:pharmacology*; D005524:Food Technology; D016166:Free Radical Scavengers / Q000138:chemical synthesis* / Q000494:pharmacology*; D005707:Gallic Acid / Q000031:analogs & derivatives*; D010851:Picrates / Q000378:metabolism*
D001713:Biphenyl Compounds; D004952:Esters; D016166:Free Radical Scavengers; D010851:Picrates; D005707:Gallic Acid; C004931:1,1-diphenyl-2-picrylhydrazyl; D001205:Ascorbic Acid