Transcatheter Arterial Chemoembolization Plus131I-Labelled Metuximab versus Transcatheter Arterial Chemoembolization Alone in Intermediate/Advanced Stage Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis.
The aim of the study was to compare transcatheter arterial chemoembolization (TACE) plus131I-labelled metuximab with TACE alone for hepatocellular carcinoma (HCC).



A comprehensive search was conducted in PubMed, Embase, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, and Chinese BioMedical Literature Database with published date from the earliest to February 29th, 2016. No language restrictions were applied, but only prospective randomized controlled trials (RCTs) or non-RCTs were eligible for a full-text review. The primary outcome was the overall survival (OS) and effective rate (the rate of partial atrophy or complete clearance of the tumor lesion). The odds ratios (ORs) were combined using either the fixed-effects model or random-effects model.



Eight trials (3 RCTs and 5 non-RCTs) were included, involving a total of 1121 patients. Patients receiving combined therapy of TACE plus131I-labelled metuximab showed significant improvement in effective rate {OR = 4.00, (95% confidence interval [CI]: 2.40-6.66),p< 0.001}, 1-year OS (OR = 2.03 [95% CI: 1.55-2.67],p< 0.001) and 2-year OS (OR = 2.57 [95% CI: 1.41-4.66],p= 0.002].



TACE plus131I-labelled metuximab is more beneficial for treating advanced HCCs than TACE alone in terms of tumor response and OS. Large, multi-center, and blinded randomized trials are required to confirm these findings.
Department of Liver Surgery, Liver Transplantation Division, West China Hospital, Sichuan University, Chengdu 610041, China.
Ze-Xin
ZX
Zhu
Department of Liver Surgery, Liver Transplantation Division, West China Hospital, Sichuan University, Chengdu 610041, China.
Ming-Heng
MH
Liao
Department of Dermatovenereology, West China Hospital, Sichuan University, Chengdu 610041, China.
Xiao-Xue
XX
Wang
Department of Liver Surgery, Liver Transplantation Division, West China Hospital, Sichuan University, Chengdu 610041, China.
Ji-Wei
JW
Huang
D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D006528:Carcinoma, Hepatocellular / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D016461:Chemoembolization, Therapeutic / Q000009:adverse effects; D003131:Combined Modality Therapy; D016208:Databases, Factual; D006801:Humans; D008113:Liver Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D009367:Neoplasm Staging; D016499:Radioimmunotherapy; D019275:Radiopharmaceuticals / Q000737:chemistry; D015996:Survival Rate
D000911:Antibodies, Monoclonal; D000970:Antineoplastic Agents; D019275:Radiopharmaceuticals; C511207:metuximab
131I-labelled metuximab; Hepatocellular carcinoma; Meta-analysis; Radioimmunotherapy; Transcatheter arterial chemoembolization