Investigation ofcyclin D1rs9344 G>A polymorphism in colorectal cancer: a meta-analysis involving 13,642 subjects.
The relationship betweencyclin D1(CCND1) rs9344 G>A polymorphism and colorectal cancer (CRC) risk is still ambiguous. To obtain a precise estimation of the relationship, we performed an extensive meta-analysis based on the eligible studies. Crude odds ratios with their 95% confidence intervals were harnessed to determine the strength of correlation betweenCCND1rs9344 G>A polymorphism and CRC risk under the allele, the homozygote, the dominant, and the recessive genetic models, respectively (28 studies with 5,784 CRC cases and 7,858 controls). Our results indicated evidence of the association betweenCCND1rs9344 G>A polymorphism and the increased risk of CRC in four genetic models: A vs G, AA vs GG, AA+GA vs GG, and AA vs GA+GG. In a stratified analysis by cancer type of CRC, there was an increased risk of sporadic CRC found in three genetic models: A vs G, AA vs GG, and AA+GA vs GG. In a stratified analysis by ethnicity, there was an increased CRC risk found among Asians in allele comparison genetic models, as well as Caucasians in two genetic models: AA+GA vs GG and A vs T. In summary, this meta-analysis demonstrates thatCCND1rs9344 G>A polymorphism may be a risk factor for CRC.
Department of Immunology, School of Medicine, Jiangsu University.
Hao
H
Qiu
Department of Pulmonary Medicine, Affiliated Hospital of Jiangsu University, Zhenjiang.
Chengguo
C
Cheng
Department of Cardiology, The People's Hospital of Xishuangbanna Dai Autonomous Prefecture, Jinghong.
Yafeng
Y
Wang
Department of Thoracic Surgery, Affiliated Union Hospital, Fujian Medical University, Fuzhou.
Mingqiang
M
Kang
Department of Thoracic Surgery, Affiliated Union Hospital, Fujian Medical University, Fuzhou; Department of Cardiothoracic Surgery, Affiliated People's Hospital of Jiangsu University, Zhenjiang.
Weifeng
W
Tang
Department of Thoracic Surgery, Affiliated Union Hospital, Fujian Medical University, Fuzhou.
Shuchen
S
Chen
Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai.
Haiyong
H
Gu
Department of Cardiothoracic Surgery, Affiliated People's Hospital of Jiangsu University, Zhenjiang.
Chao
C
Liu
Department of Medical Oncology, Fujian Provincial Cancer Hospital, Fujian Medical University Cancer Hospital; Fujian Provincial Key Laboratory of Translational Cancer Medicine, Fuzhou, People's Republic of China.
Yu
Y
Chen
CCND1; colorectal cancer; meta-analysis; polymorphism; susceptibility