Nonalcoholic Fatty Liver Disease: The New Complication of Type 2 Diabetes Mellitus.
Nonalcoholic fatty liver disease (NAFLD) is increasingly common in patients with type 2 diabetes mellitus (T2DM), with an estimated prevalence of 60% to 80%. The relationship of NAFLD and T2DM is complex, with each condition negatively affecting the other. Although NAFLD is associated with more metabolic and cardiovascular complications and worse hyperglycemia, T2DM accelerates the progression of liver disease in NAFLD. Despite the high prevalence and serious clinical implications, NAFLD is usually overlooked in clinical practice. This article focuses on understanding the relationship between NAFLD and T2DM, to provide better care for these complex patients.
Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Florida College of Medicine, 1600 South West Archer Road - Room H2, Gainesville, FL 32610, USA.
Fernando
F
Bril
Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Florida College of Medicine, 1600 South West Archer Road - Room H2, Gainesville, FL 32610, USA; Division of Endocrinology, Diabetes, and Metabolism, Malcom Randall Veterans Affairs Medical Center, 1601 South West Archer Road, Gainesville, FL 32608, USA. Electronic address: Kenneth.Cusi@medicine.ufl.edu.
Kenneth
K
Cusi
D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D006801:Humans; D006943:Hyperglycemia; D065626:Non-alcoholic Fatty Liver Disease / Q000150:complications*; D015995:Prevalence
Diabetes; Insulin resistance; Nonalcoholic fatty liver disease (NAFLD); Nonalcoholic steatohepatitis (NASH); Obesity; Pioglitazone; Thiazolidinediones