Ceramide as a Target of Marine Triterpene Glycosides for Treatment of Human Myeloid Leukemia.
Acute myeloid leukemia (AML) is a heterogeneous myeloid clonal disorder exhibiting the accumulation of immature myeloid progenitors in the bone marrow and peripheral blood. Standard AML therapy requires intensive combination chemotherapy, which leads to significant treatment-related toxicity. The search for new, low toxic marine agents, inducing the generation of ceramide in leukemic cells is a new approach to improve the therapy of leukemia. This review focuses on the metabolism of sphingolipids, the role of ceramide in treating leukemia, and the antitumor activity, related to ceramide metabolism, of some marine metabolites, particularly stichoposides, triterpene glycosides extracted from sea cucumbers of the family Stichopodiidae.
Department of Biochemistry, Dong-A University College of Medicine, 32 Daesingongwon-ro, Seo-Gu, Busan 49201, Korea. tpohot10@nate.com.
Seong-Hoon
SH
Yun
Department of Biochemistry, Dong-A University College of Medicine, 32 Daesingongwon-ro, Seo-Gu, Busan 49201, Korea. lunaticblue@lycos.co.kr.
Sung-Won
SW
Shin
G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Science, Vladivostok 690022, Russia. stonik@piboc.dvo.ru.|Department of Bioorganic Chemistry and Biotechnology, School of Natural Sciences, Far East Federal University, Vladivostok 690091, Russia. stonik@piboc.dvo.ru.
Valentin A
VA
Stonik
Department of Biochemistry, Dong-A University College of Medicine, 32 Daesingongwon-ro, Seo-Gu, Busan 49201, Korea. jipark@dau.ac.kr.
Joo-In
JI
Park
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D002518:Ceramides / Q000494:pharmacology*; D006027:Glycosides / Q000494:pharmacology*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy*; D012616:Sea Cucumbers / Q000737:chemistry; D013107:Sphingolipids / Q000494:pharmacology; D014315:Triterpenes / Q000494:pharmacology*
D000970:Antineoplastic Agents; D002518:Ceramides; D006027:Glycosides; D013107:Sphingolipids; D014315:Triterpenes
anti-leukemic activity; ceramide; ceramide synthase; sphingomyelinase; stichoposides