Imaging techniques: new avenues in cancer gene and cell therapy.
Cancer is one of the world's most concerning health problems and poses many challenges in the range of approaches associated with the treatment of cancer. Current understanding of this disease brings to the fore a number of novel therapies that can be useful in the treatment of cancer. Among them, gene and cell therapies have emerged as novel and effective approaches. One of the most important challenges for cancer gene and cell therapies is correct monitoring of the modified genes and cells. In fact, visual tracking of therapeutic cells, immune cells, stem cells and genetic vectors that contain therapeutic genes and the various drugs is important in cancer therapy. Similarly, molecular imaging, such as nanosystems, fluorescence, bioluminescence, positron emission tomography, single photon-emission computed tomography and magnetic resonance imaging, have also been found to be powerful tools in monitoring cancer patients who have received therapeutic cell and gene therapies or drug therapies. In this review, we focus on these therapies and their molecular imaging techniques in treating and monitoring the progress of the therapies on various types of cancer.
Bozorgmehr Imaging Center, Isfahan University of Medical Sciences, Isfahan, Iran.
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Saadatpour
Khanevadeh Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.
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A
Rezaei
Department of Oral and Maxillofacial Radiology, School of Dentistry, Kerman University of Medical Sciences, Kerman, Iran.
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H
Ebrahimnejad
Department of Endodontics, School of Dentistry, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
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B
Baghaei
Nutritional and Environmental Medicine, Mo i Rana, Norway.
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Bjorklund
DigiCare Behavioral Research, Casa Grande, AZ, USA.
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Chartrand
Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
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Sahebkar
Department of Medical Parasitology and Medical Mycology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
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Morovati
Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
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Mirzaei
Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
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Mirzaei
D000818:Animals; D015415:Biomarkers; D014408:Biomarkers, Tumor; D064987:Cell- and Tissue-Based Therapy; D003131:Combined Modality Therapy; D003952:Diagnostic Imaging / Q000379:methods; D015316:Genetic Therapy; D006801:Humans; D057054:Molecular Imaging / Q000379:methods*; D009369:Neoplasms / Q000000981:diagnostic imaging* / Q000235:genetics* / Q000628:therapy; D016896:Treatment Outcome
D015415:Biomarkers; D014408:Biomarkers, Tumor