Enantioselective synthesis of spirooxindole benzoquinolizines via organo-catalyzed cascade reactions.
A Michael-Mannich-hemiaminalization-dehydration cascade reaction was developed for the construction of spirooxindole benzoquinolizine derivatives. Additionally, spirooxindole benzoindolizidine was prepared conveniently through a ring-contracted rearrangement reaction from spirooxindole benzoquinolizine.
Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, China. sunxingwen@fudan.edu.cn.
Yu
Y
Tan
Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, China. sunxingwen@fudan.edu.cn.
Er-Lu
EL
Feng
Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, China. sunxingwen@fudan.edu.cn.
Qiang-Sheng
QS
Sun
School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, P. R. China.. linh@fudan.edu.cn.
Hua
H
Lin
School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, P. R. China.. linh@fudan.edu.cn.
Xun
X
Sun
Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, China. sunxingwen@fudan.edu.cn.
Guo-Qiang
GQ
Lin
Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, China. sunxingwen@fudan.edu.cn and Key Laboratory of Synthetic and Self-Assembly Chemistry for Organic Functional Molecules, Chinese Academy of Sciences, China.
Xing-Wen
XW
Sun