Potent Inducers of Endogenous Antimicrobial Peptides for Host Directed Therapy of Infections.
A new concept for treatment of infections is induction of our own antimicrobial peptides and the presented novel class of inducer, aroylated phenylenediamines (APDs), gives up to 20 to 30-fold induction of the human antimicrobial peptide LL-37, in vitro. In addition, oral administration of an APD in a rabbit model of Shigellosis resulted in recovery from the infection in a few days implying that APD's are promising candidates for treatment of infections.
Department of Biosciences and Nutrition, Karolinska Institutet, S-14183, Huddinge, Sweden.
H
H
Ottosson
Department of Laboratory Medicine, Karolinska Institutet, S-14186, Huddinge, Sweden.
F
F
Nylén
International Center for Diarrheal Disease Research, Bangladesh (icddr, b) Dhaka, Bangladesh.
P
P
Sarker
Department of Laboratory Medicine, Karolinska Institutet, S-14186, Huddinge, Sweden.
E
E
Miraglia
Department of Laboratory Medicine, Karolinska Institutet, S-14186, Huddinge, Sweden.
P
P
Bergman
Biomedical Center, University of Iceland, Reykjavik, Iceland.
G H
GH
Gudmundsson
International Center for Diarrheal Disease Research, Bangladesh (icddr, b) Dhaka, Bangladesh.
R
R
Raqib
Department of Laboratory Medicine, Karolinska Institutet, S-14186, Huddinge, Sweden.
B
B
Agerberth
Department of Biosciences and Nutrition, Karolinska Institutet, S-14183, Huddinge, Sweden.
R
R
Strömberg
D000284:Administration, Oral; D000818:Animals; D023181:Antimicrobial Cationic Peptides / Q000378:metabolism*; D002460:Cell Line; D004405:Dysentery, Bacillary / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D010655:Phenylenediamines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D011817:Rabbits; D054804:Cathelicidins
D023181:Antimicrobial Cationic Peptides; D010655:Phenylenediamines; D054804:Cathelicidins