Independent Factors of Changes of Ankle-Brachial Index in Peripheral Arterial Occlusive Disease in Elderly Patients with or without Diabetes.
Peripheral arterial disease (PAD) belongs to the commonly-occurring pathologies associated with elderly age. A simple tool for defining the severity of PAD is the ankle-brachial index (ABI). The purpose of this research was to determine independent factors of changes of ABI in elderly patients with occlusive PAD disease (PAOD) with and without diabetes. The research was carried out on 49 elderly patients with PAOD, including 29 patients with type 2 diabetes, and 20 patients without diabetes. The concentration of interleukin-6 (IL-6), E-selectin, fibrinogen, and C-reactive protein (CRP) in the blood serum was marked. In all patients, the independent factors of changes of ABI were determined with the use of the multiple logistic regression analysis. Our results show that in the group of patients with PAOD suffering from diabetes, it was demonstrated that the ABI was related to age, the duration of the symptoms of PAD, body mass index (BMI), low-density lipoprotein cholesterol, fibrinogen, and sex (determination coefficient R² = 0.699). In patients with PAOD without diabetes, the ABI was related to age, the duration of the symptoms of PAD, the levels of CRP, E-selectin, high-density lipoprotein cholesterol, and the glomerular filtration rate(determination coefficient R² = 0.844). We conclude that in elderly patients with PAOD with and without diabetes, the participation of independent factors related to the ABI is diversified; in patients with diabetes, the concentration of IL-6 and fibrinogen is lower, and the concentration of E-selectin is higher than in patients without diabetes.
Faculty of Health Sciences, University of Bielsko-Biala, 43-309 Bielsko-Biala, Poland. ewelina.bak76@wp.pl.
Ewelina
E
Bąk
Department of Gerontology and Geriatric Nursing, School of Health Sciences, Medical University of Silesia, 40-752 Katowice, Poland. klinwewtychy@poczta.onet.pl.
Czesław
C
Marcisz
Faculty of Health Sciences, University of Bielsko-Biala, 43-309 Bielsko-Biala, Poland. mkadlubowska@ath.bielsko.pl.
Monika
M
Kadłubowska
Faculty of Health Sciences, University of Bielsko-Biala, 43-309 Bielsko-Biala, Poland. amichalik@ath.bielsko.pl.
Anna
A
Michalik
Faculty of Health Sciences, University of Bielsko-Biala, 43-309 Bielsko-Biala, Poland. bkrawczyk@ath.bielsko.pl.
Bożena
B
Krawczyk
Department of Nursing Propaedeutics, School of Health Sciences, Medical University of Silesia, 40-752 Katowice, Poland. dorotadobrzyn@op.pl.
Dorota
D
Dobrzyń-Matusiak
Department of Clinical Nursing Faculty of Health Sciences, Medical University, 50-367 Wroclaw, Poland. s.krzeminska@wp.pl.
Sylwia
S
Krzemińska
Department of Rehabilitation, Medical University, Provincial Hospital in Bielsko-Biala, 43-309 Bielsko-Biala, Poland. tomasz_f@poczta.onet.pl.
Tomasz
T
Fiałkowski
Specialist Psychiatric Health Care Center, 43-309 Bielsko-Biala, Poland. ela.gladys@vp.pl.
Elżbieta
E
Glądys
School of Health Sciences in Katowice, Medical University of Silesia, Chair of Woman's Health, 40-752 Katowice, Poland. cor111@poczta.onet.pl.
Agnieszka
A
Drosdzol-Cop
D000368:Aged; D055109:Ankle Brachial Index / Q000706:statistics & numerical data; D001157:Arterial Occlusive Diseases / Q000150:complications / Q000503:physiopathology*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000503:physiopathology*; D005260:Female; D006801:Humans; D035002:Lower Extremity / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D058729:Peripheral Arterial Disease / Q000150:complications / Q000503:physiopathology*; D011044:Poland; D012307:Risk Factors
ankle-brachial index; diabetes; elderly; peripheral arterial disease