Lactate Wreaks Havoc on Tumor-Infiltrating T and NK Cells.
Both cancer cells and activated T and NK immune cells display enhanced nutrient uptake and metabolism characteristic of the Warburg phenotype. In this issue of Cell Metabolism, Brand et al. (2016) demonstrate that cancer cell LDHA-derived lactic acid selectively disables T and NK cell activation and tumor immune surveillance.
Department of Tumor Biology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.
Kristen E N
KE
Scott
Department of Tumor Biology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA. Electronic address: John.Cleveland@moffitt.org.
John L
JL
Cleveland
D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D019344:Lactic Acid; D008213:Lymphocyte Activation / Q000276:immunology; D009369:Neoplasms / Q000276:immunology
D019344:Lactic Acid