Involvement of dihydropyridine-sensitive calcium channels in high asynchrony of transmitter release in neuromuscular synapses of newborn rats.
Experiments on neuromuscular synapses of rats at different stages of ontogenesis have been performed. It has been found that one of the reasons of higher asynchrony of the release of single quanta of acetylcholine in the synapses of newborn animals is the activity of the presynaptic dihydropyridine-sensitive calcium channels of the L-type.
Kazan Institute of Biochemistry and Biophysics, Kazan Scientific Center, Russian Academy of Sciences, Kazan, Tatarstan, Russia.|Kazan (Volga Region) Federal University, Kazan, Tatarstan, Russia.
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Khuzakhmetova
Kazan Institute of Biochemistry and Biophysics, Kazan Scientific Center, Russian Academy of Sciences, Kazan, Tatarstan, Russia.|Kazan (Volga Region) Federal University, Kazan, Tatarstan, Russia.
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Nurullin
Kazan Institute of Biochemistry and Biophysics, Kazan Scientific Center, Russian Academy of Sciences, Kazan, Tatarstan, Russia. ellyab@mail.ru.|Kazan (Volga Region) Federal University, Kazan, Tatarstan, Russia. ellyab@mail.ru.
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Bukharaeva
Kazan Institute of Biochemistry and Biophysics, Kazan Scientific Center, Russian Academy of Sciences, Kazan, Tatarstan, Russia.|Kazan (Volga Region) Federal University, Kazan, Tatarstan, Russia.|Kazan State Medical University, Kazan, Tatarstan, Russia.
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Nikolsky
D000109:Acetylcholine / Q000378:metabolism*; D000818:Animals; D000831:Animals, Newborn; D002121:Calcium Channel Blockers / Q000008:administration & dosage; D020746:Calcium Channels, L-Type / Q000187:drug effects / Q000502:physiology*; D004095:Dihydropyridines / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D066298:In Vitro Techniques; D015640:Ion Channel Gating / Q000187:drug effects / Q000502:physiology*; D055495:Neurogenesis / Q000502:physiology; D009469:Neuromuscular Junction / Q000187:drug effects / Q000502:physiology*; D018377:Neurotransmitter Agents / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology*
D002121:Calcium Channel Blockers; D020746:Calcium Channels, L-Type; D004095:Dihydropyridines; D018377:Neurotransmitter Agents; C038806:1,4-dihydropyridine; D000109:Acetylcholine