Acute myeloid leukemia therapy elicits durable complete response in chemoradio-resistant metastatic paraganglioma.
Few effective therapeutic options exist for patients with metastatic paraganglioma (PGL). We report the case of a 16-year-old male who developed acute myeloid leukemia (AML) 30 months following the treatment for metastatic PGL. PGL had been refractory to131I-meta-iodobenzylguanidine and temozolomide therapy. However, there was a major reduction in primary tumor allowing its gross total resection, and complete resolution of metastatic disease following AML-directed therapy that included daunorubicin, cytarabine, and etoposide. He remains in remission for both AML and PGL, 48 months post AML chemotherapy. Alternative chemotherapeutic agents should be considered for metastatic PGL resistant to conventional therapy.
Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York.
Sameer
S
Sait
Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York.
Rachel
R
Kobos
Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York.
Michael P
MP
LaQuaglia
Department of Radiology, Memorial Sloan Kettering Cancer Center, New York.
Neeta
N
Pandit-Taskar
Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York.
Shakeel
S
Modak
D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D059248:Chemoradiotherapy; D003561:Cytarabine / Q000627:therapeutic use*; D003606:Dacarbazine / Q000031:analogs & derivatives / Q000627:therapeutic use; D003630:Daunorubicin / Q000627:therapeutic use*; D019008:Drug Resistance, Neoplasm; D005047:Etoposide / Q000627:therapeutic use*; D006801:Humans; D007462:Iodobenzenes / Q000627:therapeutic use; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy*; D008297:Male; D010235:Paraganglioma / Q000188:drug therapy*; D011836:Radiation Tolerance / Q000502:physiology; D000077204:Temozolomide
D007462:Iodobenzenes; D003561:Cytarabine; C004287:iodobenzylmalonate; D005047:Etoposide; D003606:Dacarbazine; D000077204:Temozolomide; D003630:Daunorubicin
acute myeloid leukemia; chemotherapy; metastatic paraganglioma