A Child with Local Lipohypertrophy following Recombinant Human Growth Hormone Administration.
Local lipohypertrophy due to recombinant human growth hormone (rhGH) administration is a rare phenomenon. Here, we report a case of an 11-year-old girl who presented with a paraumbilical swelling, approximately one year after the start of rhGH treatment for short stature due to the presumed diagnosis of partial growth hormone insensitivity. Ultrasound imaging revealed an asymmetric distribution of subcutaneous fat tissue at the rhGH administration site, indicating local lipohypertrophy. After sparing her routine injection site and alternating other sites, the swelling disappeared within 6 months. Although the precise cause of local lipohypertrophy resulting from rhGH administration is still unclear, it might be related to the presumed diagnosis of partial growth hormone insensitivity.
Department of Pediatric Gastroenterology, Emma Children's Hospital, Academic Medical Center, Amsterdam, Netherlands.
Ilan J N
IJ
Koppen
Pediatric Surgical Centre Amsterdam, VUMC/Emma Children's Hospital, Academic Medical Center, Amsterdam, Netherlands.
Roel
0000-0001-5884-2997
R
Bakx
Department of Pediatric Endocrinology, Emma Children's Hospital, Academic Medical Center, Amsterdam, Netherlands.
Chris C
CC
de Kruiff
Department of Pediatric Endocrinology, Emma Children's Hospital, Academic Medical Center, Amsterdam, Netherlands.
A S Paul
0000-0002-9677-7441
AS
van Trotsenburg