Slip slidin' away of mitosis with CRL2Zyg11.
The spindle assembly checkpoint arrests mitotic cells by preventing degradation of cyclin B1 by the anaphase-promoting complex/cyclosome, but some cells evade this checkpoint and slip out of mitosis. Balachandran et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201601083) show that the E3 ligase CRL2ZYG11degrades cyclin B1, allowing mitotic slippage.
Department of Genetics, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem Safra Campus, Jerusalem 9190401, Israel michael.brandeis@mail.huji.ac.il.
Michael
M
Brandeis
D064173:Anaphase-Promoting Complex-Cyclosome / Q000378:metabolism; D000818:Animals; D059447:Cell Cycle Checkpoints; D056744:Cyclin B1 / Q000378:metabolism; D006801:Humans; D008870:Microtubules / Q000378:metabolism; D008938:Mitosis; D008941:Spindle Apparatus / Q000378:metabolism; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism*
D056744:Cyclin B1; D064173:Anaphase-Promoting Complex-Cyclosome; D044767:Ubiquitin-Protein Ligases