Role of CTGF in Sensitivity to Hyperthermia in Ovarian and Uterine Cancers.
Even though hyperthermia is a promising treatment for cancer, the relationship between specific temperatures and clinical benefits and predictors of sensitivity of cancer to hyperthermia is poorly understood. Ovarian and uterine tumors have diverse hyperthermia sensitivities. Integrative analyses of the specific gene signatures and the differences in response to hyperthermia between hyperthermia-sensitive and -resistant cancer cells identified CTGF as a key regulator of sensitivity. CTGF silencing sensitized resistant cells to hyperthermia. CTGF small interfering RNA (siRNA) treatment also sensitized resistant cancers to localized hyperthermia induced by copper sulfide nanoparticles and near-infrared laser in orthotopic ovarian cancer models. CTGF silencing aggravated energy stress induced by hyperthermia and enhanced apoptosis of hyperthermia-resistant cancers.
Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center (MDACC), Houston, TX 77030, USA.
Hiroto
H
Hatakeyama
Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center (MDACC), Houston, TX 77030, USA.
Sherry Y
SY
Wu
Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center (MDACC), Houston, TX 77030, USA.
Yasmin A
YA
Lyons
Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center (MDACC), Houston, TX 77030, USA.
Sunila
S
Pradeep
Department of Cancer Systems Imaging, MDACC, Houston, TX 77030, USA.
Wanqin
W
Wang
Department of Cancer Systems Imaging, MDACC, Houston, TX 77030, USA.
Qian
Q
Huang
Department of Chemical Engineering, University of Puerto Rico-Mayaguez, Mayaguez, PR 00681, Puerto Rico.
Karem A
KA
Court
Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA.
Tao
T
Liu
Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA.
Song
S
Nie
Department of Experimental Therapeutics, MDACC, Houston, TX 77030, USA.
Cristian
C
Rodriguez-Aguayo
Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center (MDACC), Houston, TX 77030, USA.
Fangrong
F
Shen
Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center (MDACC), Houston, TX 77030, USA.
Yan
Y
Huang
Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center (MDACC), Houston, TX 77030, USA.
Takeshi
T
Hisamatsu
Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center (MDACC), Houston, TX 77030, USA; Department of Obstetrics and Gynecology, Hokkaido University Graduate School of Medicine, Sapporo 060-8648, Japan.
Takashi
T
Mitamura
Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center (MDACC), Houston, TX 77030, USA.
Nicholas
N
Jennings
Department of Systems Biology, MDACC, Houston, TX 77030, USA.
Jeajun
J
Shim
Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center (MDACC), Houston, TX 77030, USA.
Piotr L
PL
Dorniak
Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center (MDACC), Houston, TX 77030, USA; Center for RNA Interference and Non-Coding RNAs, MDACC, Houston, TX 77030, USA.
Lingegowda S
LS
Mangala
Department of Gynecologic Oncology, Catholic University of the Sacred Heart, Rome 00168, Italy.
Marco
M
Petrillo
Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA.
Vladislav A
VA
Petyuk
Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA.
Athena A
AA
Schepmoes
Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA.
Anil K
AK
Shukla
Department of Chemical Engineering, University of Puerto Rico-Mayaguez, Mayaguez, PR 00681, Puerto Rico.
Madeline
M
Torres-Lugo
Department of Systems Biology, MDACC, Houston, TX 77030, USA.
Ju-Seog
JS
Lee
Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA.
Karin D
KD
Rodland
Department of Medicine and Surgery, Catholic University of the Sacred Heart, Rome 00168, Italy.
Anna
A
Fagotti
Department of Experimental Therapeutics, MDACC, Houston, TX 77030, USA; Center for RNA Interference and Non-Coding RNAs, MDACC, Houston, TX 77030, USA; Department of Cancer Biology, MDACC, Houston, TX 77030, USA.
Gabriel
G
Lopez-Berestein
Department of Cancer Systems Imaging, MDACC, Houston, TX 77030, USA.
Chun
C
Li
Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center (MDACC), Houston, TX 77030, USA; Center for RNA Interference and Non-Coding RNAs, MDACC, Houston, TX 77030, USA; Department of Cancer Biology, MDACC, Houston, TX 77030, USA. Electronic address: asood@mdanderson.org.
Anil K
AK
Sood
D000818:Animals; D045744:Cell Line, Tumor; D055513:Connective Tissue Growth Factor / Q000378:metabolism*; D005260:Female; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D020868:Gene Silencing; D052138:Genes, Neoplasm; D006801:Humans; D006979:Hyperthermia, Induced; D051379:Mice; D008954:Models, Biological; D010051:Ovarian Neoplasms / Q000235:genetics / Q000378:metabolism*; D040901:Proteomics; D014594:Uterine Neoplasms / Q000235:genetics / Q000378:metabolism*
C526317:CCN2 protein, human; D055513:Connective Tissue Growth Factor
CTGF; DOPC-liposome; copper sulfide nanoparticle; hyperthermia; ovarian cancer; thermosensitivity