Toxoplasmic Encephalitis with Untreated Hairy Cell Leukemia Variant.
Toxoplasmic encephalitis is a rare infectious complication in patients with hematological malignancy except for allogeneic hematopoietic stem cell transplantation (HSCT). We herein report a case of possible toxoplasmic encephalitis with untreated hairy cell leukemia variant. Magnetic resonance imaging showed multiple nodules with surrounding edema in the entire cerebrum. A polymerase chain reaction analysis for Toxoplasma gondii was negative. Her signs and symptoms fully recovered by empirical therapy with sulfadiazine and pyrimethamine. Toxoplasmic encephalitis may occur in patients who undergo non-allogeneic HSCT for hematological malignancies, even in those who have not been treated.
Department of Hematology, Almeida Memorial Hospital, Japan.
Taichi
T
Ikebe
Hitohiro
H
Sasaki
Hiroyuki
H
Takata
Yasuhiko
Y
Miyazaki
Eiichi
E
Ohtsuka
Yoshio
Y
Saburi
Masao
M
Ogata
Kuniaki
K
Shirao
D000368:Aged; D000818:Animals; D000981:Antiprotozoal Agents / Q000627:therapeutic use; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D005260:Female; D006429:Hemiplegia / Q000209:etiology; D006801:Humans; D000069544:Infectious Encephalitis / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000188:drug therapy; D007943:Leukemia, Hairy Cell / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000188:drug therapy; D008279:Magnetic Resonance Imaging; D011739:Pyrimethamine / Q000627:therapeutic use; D013411:Sulfadiazine / Q000627:therapeutic use; D014122:Toxoplasma / Q000302:isolation & purification; D016781:Toxoplasmosis, Cerebral / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000188:drug therapy
D000981:Antiprotozoal Agents; D013411:Sulfadiazine; D011739:Pyrimethamine