Simultaneous SEEG-MEG-EEG recordings Overcome the SEEG limited spatial sampling.
During presurgical evaluation of pharmacoresistant partial epilepsies, stereoelectroencephalography (SEEG) records interictal and ictal activities directly but is inherently limited in spatial sampling. In contrast, scalp-EEG and MEG are less sensitive but provide a global view on brain activity. Therefore, recording simultaneously these three modalities should provide a better understanding of the underlying brain sources by taking advantage of the different sensitivities of the three recording techniques. We performed trimodal EEG-MEG-SEEG recordings in a 19-year-old woman with pharmacoresistant cryptogenic posterior cortex epilepsy. Sub-continuous and highly focal spikes that were not visible at the surface were marked on SEEG by an epileptologist. Surface signals, MEG and scalp-EEG, were then averaged locked on SEEG spikes. MEG sources were reconstructed based on a moving dipole approach (Brainstorm software). This analysis revealed source within the left occipital pole, located posteriorly to the SEEG leads presenting the maximal number of spikes, in a region not explored by SEEG. In summary, simultaneous recordings provide a new framework for obtaining a view on brain signals that is both local and global, thereby overcoming the inherent SEEG limited spatial sampling.
Aix Marseille Univ, Inserm, INS, Institut de Neurosciences des Systèmes, Marseille, France; AP-HM, Hôpital de la Timone, Service de Neurophysiologie Clinique, Marseille, F-13005, France.
Martine
M
Gavaret
Aix Marseille Univ, Inserm, INS, Institut de Neurosciences des Systèmes, Marseille, France; Aix Marseille Université, CNRS, LPC UMR 7290, 13331 Marseille, France.
Anne-Sophie
AS
Dubarry
Aix Marseille Univ, Inserm, INS, Institut de Neurosciences des Systèmes, Marseille, France; AP-HM, Hôpital de la Timone, Service de Neurochirurgie Fonctionnelle, Marseille, F-13005, France.
Romain
R
Carron
Aix Marseille Univ, Inserm, INS, Institut de Neurosciences des Systèmes, Marseille, France; AP-HM, Hôpital de la Timone, Service de Neurophysiologie Clinique, Marseille, F-13005, France.
Fabrice
F
Bartolomei
Aix Marseille Univ, Inserm, INS, Institut de Neurosciences des Systèmes, Marseille, France; AP-HM, Hôpital de la Timone, Service de Neurophysiologie Clinique, Marseille, F-13005, France.
Agnès
A
Trébuchon
Aix Marseille Univ, Inserm, INS, Institut de Neurosciences des Systèmes, Marseille, France. Electronic address: christian.benar@univ-amu.fr.
Christian-George
CG
Bénar
D001921:Brain / Q000000981:diagnostic imaging / Q000503:physiopathology; D000069279:Drug Resistant Epilepsy / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000503:physiopathology; D004567:Electrodes, Implanted; D004569:Electroencephalography / Q000379:methods*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D015225:Magnetoencephalography / Q000379:methods*; D064847:Multimodal Imaging / Q000379:methods; D049268:Positron-Emission Tomography; D012815:Signal Processing, Computer-Assisted; D012984:Software; D055815:Young Adult
EEG; Epilepsy; MEG; SEEG; Source localization