Alcohol Consumption and the Risk of Colorectal Cancer for Mismatch Repair Gene Mutation Carriers.
Background:People with germline mutation in one of the DNA mismatch repair (MMR) genes have increased colorectal cancer risk. For these high-risk people, study findings of the relationship between alcohol consumption and colorectal cancer risk have been inconclusive.Methods:1,925 MMR gene mutations carriers recruited into the Colon Cancer Family Registry who had completed a questionnaire on lifestyle factors were included. Weighted Cox proportional hazard regression models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI) for the association between alcohol consumption and colorectal cancer.Results:Colorectal cancer was diagnosed in 769 carriers (40%) at a mean (SD) age of 42.6 (10.3) years. Compared with abstention, ethanol consumption from any alcoholic beverage up to 14 g/day and >28 g/day was associated with increased colorectal cancer risk (HR, 1.50; 95% CI, 1.09-2.07 and 1.69; 95% CI, 1.07-2.65, respectively;Ptrend= 0.05), and colon cancer risk (HR, 1.78; 95% CI, 1.27-2.49 and 1.94; 95% CI, 1.19-3.18, respectively;Ptrend= 0.02). However, there was no clear evidence for an association with rectal cancer risk. Also, there was no evidence for associations between consumption of individual alcoholic beverage types (beer, wine, spirits) and colorectal, colon, or rectal cancer risk.Conclusions:Our data suggest that alcohol consumption, particularly more than 28 g/day of ethanol (∼2 standard drinks of alcohol in the United States), is associated with increased colorectal cancer risk for MMR gene mutation carriers.Impact:Although these data suggested that alcohol consumption in MMR carriers was associated with increased colorectal cancer risk, there was no evidence of a dose-response, and not all types of alcohol consumption were associated with increased risk.Cancer Epidemiol Biomarkers Prev; 26(3); 366-75. ©2016 AACR.
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia.
S Ghazaleh
SG
Dashti
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia.|Colorectal Oncogenomics Group, Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Parkville, Victoria, Australia.
Daniel D
DD
Buchanan
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia.|Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria, Australia.
Harindra
H
Jayasekara
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia.
Driss
D
Ait Ouakrim
Colorectal Oncogenomics Group, Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Parkville, Victoria, Australia.
Mark
M
Clendenning
Colorectal Oncogenomics Group, Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Parkville, Victoria, Australia.|School of Medicine, University of Queensland, Herston, Queensland, Australia.
Christophe
C
Rosty
Department of Medicine, Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia.|Genetic Medicine and Family Cancer Clinic, Royal Melbourne Hospital, Parkville, Victoria, Australia.
Ingrid M
IM
Winship
Department of Medicine, Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia.|Genetic Medicine and Family Cancer Clinic, Royal Melbourne Hospital, Parkville, Victoria, Australia.|Colorectal Medicine and Genetics, The Royal Melbourne Hospital, Parkville, Victoria, Australia.
Finlay A
FA
Macrae
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia.|Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria, Australia.
Graham G
GG
Giles
New Zealand Familial Gastrointestinal Cancer Service, Auckland Hospital, Auckland, New Zealand.
Susan
S
Parry
Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California.
Graham
G
Casey
Department of Medicine, Division of Oncology, Stanford Cancer Institute, Stanford University, California.
Robert W
RW
Haile
Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.
Steven
S
Gallinger
Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.
Loïc
L
Le Marchand
Molecular Genetics Laboratory, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota.
Stephen N
SN
Thibodeau
Department of Health Science Research, Mayo Clinic Arizona, Scottsdale, Arizona.
Noralane M
NM
Lindor
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.|School of Public Health, University of Washington, Seattle, Washington.
Polly A
PA
Newcomb
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.|School of Public Health, University of Washington, Seattle, Washington.|Centre for Public Health Research, Massey University, Wellington, New Zealand.
John D
JD
Potter
Department of Medicine, University of North Carolina, Chapel Hill, North Carolina.
John A
JA
Baron
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia.|Department of Epidemiology and Institute of Health and Environment, School of Public Health, Seoul National University, Seoul, Korea.
John L
JL
Hopper
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia.
Mark A
MA
Jenkins
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia. awin@unimelb.edu.au.
Aung Ko
AK
Win
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000428:Alcohol Drinking / Q000453:epidemiology* / Q000235:genetics; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000453:epidemiology* / Q000235:genetics; D053843:DNA Mismatch Repair; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000009:adverse effects; D005260:Female; D018095:Germ-Line Mutation / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D012004:Rectal Neoplasms / Q000453:epidemiology* / Q000235:genetics; D012042:Registries; D011795:Surveys and Questionnaires; D055815:Young Adult
D000431:Ethanol