Expedited access to thieno[3,2-c]quinolin-4(5H)-ones and benzo[h]-1,6-naphthyridin-5(6H)-ones via a continuous flow photocyclization method.
A single-step continuous flow method has been developed that gives expedited access to complex heterocycles via an intramolecular photochemical cyclization. Herein we report the first examples of the photochemically-induced generation of thieno[3,2-c]quinolin-4(5H)-ones, 16 examples, and benzo[h]-1,6-naphthyridin-5(6H)-ones, 6 examples. Overall, the continuous flow method provides access to complex heterocycles in two steps from commercially available starting materials in good yields and with greater atom efficiency than traditional batch reactions.
College of Pharmacy, Faculty of Health Science, University of Manitoba, Winnipeg, MB, CanadaR3E 0T5. geoffrey.tranmer@umanitoba.ca.
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Fang
College of Pharmacy, Faculty of Health Science, University of Manitoba, Winnipeg, MB, CanadaR3E 0T5. geoffrey.tranmer@umanitoba.ca and Department of Chemistry, Faculty of Science, University of Manitoba, Winnipeg, MB, CanadaR3T 2N2.
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http://orcid.org/0000-0002-9774-8685
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Tranmer