Long-term survival outcomes in patients with surgically treated oropharyngeal cancer and defined human papilloma virus status.
OBJECTIVE
This study investigated long-term survival outcomes in surgically treated oropharyngeal cancer patients with known human papilloma virus status.


METHODS
A case note review was performed of all patients undergoing primary surgery for oropharyngeal cancer in a single centre over a 10-year period. Human papilloma virus status was determined via dual modality testing. Associations between clinicopathological variables and survival were identified using a log-rank test.


RESULTS
Of the 107 cases in the study, 40 per cent (n = 41) were human papilloma virus positive. The positive and negative predictive values of p16 immunohistochemistry for human papilloma virus status were 57 per cent and 100 per cent, respectively. At a mean follow up of 59.5 months, 5-year overall and disease-specific survival estimates were 78 per cent and 69 per cent, respectively. Human papilloma virus status (p = 0.014), smoking status (p = 0.021) and tumour stage (p = 0.03) were significant prognostic indicators.


CONCLUSIONS
The long-term survival rates in surgically treated oropharyngeal cancer patients were comparable to other studies. Variables including human papilloma virus status and tumour stage were associated with survival in patients treated with primary surgery; however, nodal stage and presence of extracapsular spread were non-prognostic.
Head and Neck Department,John Radcliffe and Churchill Hospitals,Oxford,UK.
O T
OT
Dale
ENT Department,Great Western Hospital,Swindon,UK.
S
S
Sood
Head and Neck Department,John Radcliffe and Churchill Hospitals,Oxford,UK.
K A
KA
Shah
Department of Oncology,University of Oxford,UK.
C
C
Han
Institute of Head and Neck Studies and Education,University of Birmingham,UK.
D
D
Rapozo
Institute of Head and Neck Studies and Education,University of Birmingham,UK.
H
H
Mehanna
Head and Neck Department,John Radcliffe and Churchill Hospitals,Oxford,UK.
S C
SC
Winter
D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000601:surgery* / Q000821:virology*; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006258:Head and Neck Neoplasms / Q000473:pathology / Q000601:surgery* / Q000821:virology*; D052162:Human papillomavirus 16; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009959:Oropharyngeal Neoplasms / Q000473:pathology / Q000601:surgery* / Q000821:virology*; D030361:Papillomavirus Infections / Q000821:virology*; D011237:Predictive Value of Tests; D011379:Prognosis; D000077195:Squamous Cell Carcinoma of Head and Neck
Head And Neck Neoplasms; Oropharyngeal Neoplasms; Squamous Cell Carcinoma