Biscogniauxone, a New Isopyrrolonaphthoquinone Compound from the Fungus Biscogniauxia mediterranea Isolated from Deep-Sea Sediments.
The properties and the production of new metabolites from the fungal strain LF657 isolated from the Herodotes Deep (2800 m depth) in the Mediterranean Sea are reported in this study. The new isolate was identified asBiscogniauxia mediterraneabased on ITS1-5.8S-ITS2 and 28S rRNA gene sequences. A new isopyrrolonaphthoquinone with inhibitory activity against glycogen synthase kinase (GSK-3β) was isolated from this fungus. This is the first report of this class of compounds from a fungus isolated from a deep-sea sediment, as well as from aBiscogniauxiaspecies.
GEOMAR Helmholtz Center for Ocean Research Kiel, RD3 Marine Microbiology, Düsternbrooker Weg 20, 24105 Kiel, Germany. wubin@zju.edu.cn.|Ocean College, Zhejiang University, Hangzhou 310058, China. wubin@zju.edu.cn.
Bin
B
Wu
GEOMAR Helmholtz Center for Ocean Research Kiel, RD3 Marine Microbiology, Düsternbrooker Weg 20, 24105 Kiel, Germany. jwiese@geomar.de.
Jutta
J
Wiese
GEOMAR Helmholtz Center for Ocean Research Kiel, RD3 Marine Microbiology, Düsternbrooker Weg 20, 24105 Kiel, Germany. rschmaljohann@geomar.de.
Rolf
R
Schmaljohann
GEOMAR Helmholtz Center for Ocean Research Kiel, RD3 Marine Microbiology, Düsternbrooker Weg 20, 24105 Kiel, Germany. jimhoff@geomar.de.
Johannes F
JF
Imhoff
D016227:Benzoquinones / Q000737:chemistry* / Q000494:pharmacology*; D005658:Fungi / Q000737:chemistry* / Q000235:genetics; D019015:Geologic Sediments / Q000382:microbiology*; D000071679:Glycogen Synthase Kinase 3 beta / Q000037:antagonists & inhibitors; D008522:Mediterranean Sea; D012335:RNA, Ribosomal / Q000235:genetics; D012623:Seawater / Q000382:microbiology*; D013098:Xylariales / Q000737:chemistry* / Q000235:genetics
D016227:Benzoquinones; D012335:RNA, Ribosomal; C004532:quinone; D000071679:Glycogen Synthase Kinase 3 beta
Biscogniauxia mediterranea; acetylcholinesterase; deep sea; glycogen synthase kinase; marine fungi