Impairment of the executive attention network in premenopausal women with hormone receptor-positive breast cancer treated with tamoxifen.
Tamoxifen (TAM) is most commonly prescribed for patients with hormone-sensitive breast cancer and exerts agonistic/antagonistic effects on estrogen receptors throughout the body. Accumulating evidence has revealed that breast cancer patients receiving TAM manifest cognitive dysfunction. However, whether these patients have a global attention deficit or a more selective impairment of specific attention networks remains unknown. In the present study, we sought to explore the attention function of premenopausal women with hormone receptor-positive breast cancer treated with TAM using the attention network test (ANT). The subjects included breast cancer patients receiving TAM (TAM, N=43), breast cancer patients not receiving TAM (non-TAM, N=41), and matched healthy controls (HC, N=46). The subjects completed the ANT and neuropsychological tests, which measure three independent attention networks and executive function performance, respectively. Our results indicated that patients in the TAM group had significant deficits in their executive control component but not in the alerting or orienting components. Moreover, the patients showed poor executive function performance in the neuropsychological tests. Additionally, in the TAM group, significant correlations were found between the decreased efficiency of the executive control component and their reduced performance in executive function tests. This study demonstrates that premenopausal women with hormone receptor-positive breast cancer treated with TAM have impairment of the executive attention network and that this impairment was associated with differences in executive function performance.
Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, China; Department of Medical Psychology, Anhui Medical University, Hefei, China.
Xingui
X
Chen
Department of Oncology, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.
Jingjing
J
Li
Department of Breast and Thyroid Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Jingjie
J
Zhang
Center for Biomedical Engineering, University of Science and Technology of China, Hefei, China.
Xiaoxuan
X
He
Department of Medical Psychology, Anhui Medical University, Hefei, China.
Chunyan
C
Zhu
Department of Medical Psychology, Anhui Medical University, Hefei, China.
Lei
L
Zhang
Anhui Mental Health Center, Hefei, China.
Xinglong
X
Hu
Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, China; Department of Medical Psychology, Anhui Medical University, Hefei, China. Electronic address: wangkai1964@126.com.
Kai
K
Wang
D000328:Adult; D001288:Attention / Q000187:drug effects*; D001943:Breast Neoplasms / Q000188:drug therapy*; D060825:Cognitive Dysfunction / Q000139:chemically induced*; D004965:Estrogen Antagonists / Q000009:adverse effects*; D056344:Executive Function / Q000187:drug effects*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009376:Neoplasms, Hormone-Dependent / Q000188:drug therapy*; D017697:Premenopause / Q000187:drug effects*; D013629:Tamoxifen / Q000009:adverse effects*
D004965:Estrogen Antagonists; D013629:Tamoxifen
Attention network test; Breast cancer; Endocrine therapy; Executive function; Tamoxifen