Pituitary tumor transforming gene-1 in non-small cell lung cancer: Clinicopathological and immunohistochemical analysis.
Pituitary tumor transforming gene-1 (PTTG1) is a novel oncogene and overexpressed in a wide variety of human cancers. However, the clinical and prognostic significance of PTTG1 in non-small cell lung cancer (NSCLC) is still unknown. The expression status of PTTG1 in NSCLC at the publicly available GEO databases (GSE19804) was observed. The mRNA and protein expression of PTTG1 in NSCLC tissues and cell lines was detected by qRT-PCR and Western blot, and the association between PTTG1 expression and clinicopathological factors was analyzed by immunohistochemistry. In our Results, PTTG1 was one of genes overexpressed in NCSLC samples compared with paired adjacent normal lung samples in microarray data (GSE19804). PTTG1 mRNA and protein expressions were increased in NSCLC tissues and cell lines. PTTG1 protein expression was correlated with malignant status and poor prognosis of NSCLC patients. In conclusion, PTTG1 is correlated with NSCLC progression and as an independent poor prognostic factor in NSCLC patients.
Department of Respiratory Medicine, The First People's Hospital of Shangqiu, Shangqiu 476100, Henan, China.
Feng
F
Wang
Department of Respiratory Medicine, The First People's Hospital of Shangqiu, Shangqiu 476100, Henan, China.
Yanhong
Y
Liu
Department of Critical Care Medicine, Shengli Oilfield Center Hospital, Dongying 257034, Shandong, China. Electronic address: chenyan2000@hainan.com.
Yan
Y
Chen
D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics* / Q000473:pathology; D045744:Cell Line, Tumor; D018450:Disease Progression; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D016016:Proportional Hazards Models; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D064249:Securin / Q000235:genetics* / Q000378:metabolism; D015854:Up-Regulation / Q000235:genetics
D012333:RNA, Messenger; D064249:Securin; C578002:pituitary tumor-transforming protein 1, human
Biomarker; Lung cancer; Oncogene; PTGG1; Prognosis