An unusual case of basal cell carcinoma of the vulva with lung metastases.
Basal cell carcinoma (BCC) is the most common non-melanomatous skin cancer, typically arising in sun-exposed areas such as the head and neck. Defective signaling through the Hedgehog (HH) signaling pathway forms the molecular basis for BCC. Surgery remains the mainstay of treatment. Basal cell carcinoma of the genital tract is rare as is metastatic BCC. We report a case of metastatic BCC in a young woman with previously resected vulval BCC presenting six years later with inguinal nodal recurrence and multiple lung metastases.
Department of Medical Oncology, Mater Misericordiae University Hospital, Eccles St., Dublin 7, Ireland.
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Watson
Department of Medical Oncology, Mater Misericordiae University Hospital, Eccles St., Dublin 7, Ireland.
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Kelly
Department of Medical Oncology, Mater Misericordiae University Hospital, Eccles St., Dublin 7, Ireland.
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Prior
Department of Radiology, Mater Misericordiae University Hospital, Eccles St., Dublin 7, Ireland.
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Stanley
Department of Pathology, Mater Misericordiae University Hospital, Eccles St., Dublin 7, Ireland.
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MacEneaney
Department of Gynaecology, Mater Misericordiae University Hospital, Eccles St., Dublin 7, Ireland.
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Walsh
Department of Medical Oncology, Mater Misericordiae University Hospital, Eccles St., Dublin 7, Ireland.
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Kelly
Basal cell carcinoma; Hedgehog pathway; Lung metastasis; SMO inhibitors; Vismodegib; Vulva