Magnetically Controlled Drug Release System through Magnetomechanical Actuation.
A drug release system is developed capable to modulate the drug release kinetics by the application of a magnetic field. Thus, this work reports on the production, characterization, and release kinetics of a poly(l-lactic acid) (PLLA) microporous membrane containing a zeolite (Faujasite) and a magnetic stimuli-sensitive component, magnetostrictive Terfenol-D (TD), for the release of ibuprofen (IBU) as drug model. For membranes containing IBU-loaded zeolites and TD without an applied AC magnetic field, the release kinetics is characterized by a first order release. On the other hand, the application of an AC magnetic field modifies the release profile of the membrane, leading to an increase of the release rate by more than 30%, the magnetically driven release being characterized by a super case-II within the Korsmeyer-Peppas model, indicating a release mainly driven by a swelling or erosion mechanism, induced by the magnetostrictive particles under the applied magnetic field. The increase of the TD w/w from 10% to 20% has as a consequence a decrease in the quantity of IBU released from 79% to 70%; on the contrary, increasing the HACintensity from 100 to 200 mT promotes an increase on the percentage of IBU released from 67% to 75%.
Centro/Departamento de Física, Universidade do Minho, 4710-057, Braga, Portugal.
João
J
Barbosa
Centro/Departamento de Física, Universidade do Minho, 4710-057, Braga, Portugal.|Centro/Departamento de Química, Universidade do Minho, 4710-057, Braga, Portugal.
Daniela Maria
DM
Correia
Centro/Departamento de Física, Universidade do Minho, 4710-057, Braga, Portugal.|Centro/Departamento de Química, Universidade do Minho, 4710-057, Braga, Portugal.
Renato
R
Gonçalves
Centro/Departamento de Física, Universidade do Minho, 4710-057, Braga, Portugal.|CEB - Centre of Biological Engineering, University of Minho, Campus de Gualtar, 4710-057, Braga, Portugal.|Institute of Science and Innovation for Bio-Sustainability, Universidade do Minho, 4710-057, Braga, Portugal.
Clarisse
C
Ribeiro
Centro/Departamento de Química, Universidade do Minho, 4710-057, Braga, Portugal.
Gabriela
G
Botelho
Centro/Departamento de Física, Universidade do Minho, 4710-057, Braga, Portugal.
Pedro
P
Martins
Centro/Departamento de Física, Universidade do Minho, 4710-057, Braga, Portugal.|Institute of Science and Innovation for Bio-Sustainability, Universidade do Minho, 4710-057, Braga, Portugal.|BCMaterials, Parque Científico y Tecnológico de Bizkaia, 48160, Derio, Spain.|IKERBASQUE, Basque Foundation for Science, 48013, Bilbao, Spain.
Senentxu
S
Lanceros-Mendez
D003692:Delayed-Action Preparations / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry; D065546:Drug Liberation; D007052:Ibuprofen / Q000737:chemistry*; D007700:Kinetics; D060526:Magnetic Fields; D008280:Magnetics / Q000379:methods; D011091:Polyesters / Q000737:chemistry; D013730:Terphenyl Compounds / Q000737:chemistry; D017641:Zeolites / Q000737:chemistry
D003692:Delayed-Action Preparations; D004337:Drug Carriers; D011091:Polyesters; D013730:Terphenyl Compounds; C539489:faujasite; D017641:Zeolites; C040546:terferol; C033616:poly(lactide); D007052:Ibuprofen
biomedical materials; drug releases; magnetostrictive materials; membranes; zeolites