Exposure to tobacco smoke in utero or during early childhood and risk of hypomania: Prospective birth cohort study.
Using data from a prospective birth cohort, we aimed to test for an association between exposure to tobacco smoke in utero or during early development and the experience of hypomania assessed in young adulthood.



We used data on 2957 participants from a large birth cohort (Avon longitudinal study of parents and children [ALSPAC]). The primary outcome of interest was hypomania, and the secondary outcome was "hypomania plus previous psychotic experiences (PE)". Maternally-reported smoking during pregnancy, paternal smoking and exposure to environmental tobacco smoke (ETS) in childhood were the exposures of interest. Multivariable logistic regression was used and estimates of association were adjusted for socio-economic, lifestyle and obstetric factors.



There was weak evidence of an association between exposure to maternal smoking in utero and lifetime hypomania. However, there was a strong association of maternal smoking during pregnancy within the sub-group of individuals with hypomania who had also experienced psychotic symptoms (OR=3.45; 95% CI: 1.49-7.98; P=0.004). There was no association between paternal smoking, or exposure to ETS during childhood, and hypomania outcomes.



Exposure to smoking in utero may be a risk factor for more severe forms of psychopathology on the mood-psychosis spectrum, rather than DSM-defined bipolar disorder.
Institute of health & wellbeing, university of Glasgow, 1, Lilybank Gardens, G12 8RZ Glasgow, Scotland, United Kingdom. Electronic address: Daniel.Mackay@Glasgow.ac.uk.
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DF
Mackay
Institute of health & wellbeing, university of Glasgow, 1, Lilybank Gardens, G12 8RZ Glasgow, Scotland, United Kingdom.
J J
JJ
Anderson
Institute of health & wellbeing, university of Glasgow, 1, Lilybank Gardens, G12 8RZ Glasgow, Scotland, United Kingdom.
J P
JP
Pell
Department of psychological medicine and clinical neurosciences, school of medicine, Cardiff university, Cardiff, Wales, United Kingdom.
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Zammit
Institute of health & wellbeing, university of Glasgow, 1, Lilybank Gardens, G12 8RZ Glasgow, Scotland, United Kingdom.
D J
DJ
Smith
D001289:Attention Deficit Disorder with Hyperactivity / Q000139:chemically induced*; D002648:Child; D002657:Child Development / Q000187:drug effects; D002675:Child, Preschool; D005260:Female; D006801:Humans; D016015:Logistic Models; D008137:Longitudinal Studies; D008297:Male; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced*; D011446:Prospective Studies; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects*; D014028:Tobacco Smoke Pollution / Q000009:adverse effects*; D055815:Young Adult
D014028:Tobacco Smoke Pollution
Bipolar disorder; Nicotine; Post-partum; Psychoses; Tobacco