Active schistosomiasis, severe hypereosinophilia and rapid progression of chronic endomyocardial fibrosis.
Endomyocardial fibrosis (EMF) is a neglected restrictive cardiomyopathy of unknown aetiology and unclear natural history, which causes premature deaths in endemic areas. We present the case of a 13-year-old boy from a highly endemic area, presenting with concurrent signs of chronic EMF and severe hypereosinophilia associated with active schistosomal cystitis. We discuss the possible role of this parasitic infection in determining the progression of EMF in endemic areas for both conditions.
Instituto Nacional de Saúde, Maputo, Mozambique; Eduardo Mondlane University, Maputo, Mozambique. Email: amocumbi@gmail.com.
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Mocumbi
Maputo Central Hospital, Mozambique.
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Goncalves
Eduardo Mondlane University, Maputo, Mozambique; Maputo Central Hospital, Mozambique.
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Damasceno
Eduardo Mondlane University, Maputo, Mozambique; Maputo Central Hospital, Mozambique.
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Carrilho
D000293:Adolescent; D000980:Antiplatyhelmintic Agents / Q000627:therapeutic use; D001344:Autopsy; D001706:Biopsy; D002317:Cardiovascular Agents / Q000627:therapeutic use; D002908:Chronic Disease; D004719:Endomyocardial Fibrosis / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology*; D017809:Fatal Outcome; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000175:diagnosis / Q000188:drug therapy / Q000469:parasitology*; D008297:Male; D009206:Myocardium / Q000473:pathology*; D012552:Schistosomiasis / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000469:parasitology*; D012720:Severity of Illness Index; D016896:Treatment Outcome
D000980:Antiplatyhelmintic Agents; D002317:Cardiovascular Agents