Tailored poly(ethylene) glycol dimethacrylate based shape memory polymer for orthopedic applications.
Shape-memory polymers (SMPs) are stimuli-responsive materials known for their outstanding ability to be actuated from temporary shape into original shape. Because of this unique functionality SMPs are promising materials for diverse technological applications including smart biomedical devices. In this article, the work has been focused towards tailoring the SMP precursor and crosslinker wt% to obtain biocompatible acrylate based shape memory polymer with glass transition temperature (Tg) close to human body temperature. Methacrylate based shape memory polymer networks are synthesized via free radical polymerization by varying the wt% of t-butyl acrylate (tBA) and poly(ethylene glycol) dimethacrylate (PEGDMA) as crosslinker. The Tgis found to increase from 28 to 45°C with increasing tBA amount. The SMP synthesized from 70wt% of tBA and 30wt% of PEGDMA possess Tg close to human body temperature and is tested for cytotoxicity with two different cell lineages, osteosarcoma (MG-63) cells, and human keratinocyte (HaCaT) cells. The synthesized SMP is found to be non-cytotoxic. Thus the investigated biocompatible shape memory polymer network can be a promising soft substrate for passive thermomechanical stimulation which can adapt and meet specific needs of in vitro or in vivo orthopedic Superior Labrum Anterior and Posterior (SLAP) medical devices.
Structural Technologies Division, Council of Scientific and Industrial Research-National Aerospace Laboratories, HAL Airport Road, Kodihalli, Bangalore 560017, India.
G Jerald Maria
GJM
Antony
Structural Technologies Division, Council of Scientific and Industrial Research-National Aerospace Laboratories, HAL Airport Road, Kodihalli, Bangalore 560017, India.
Chethan S
CS
Jarali
Surface Engineering Division, Council of Scientific and Industrial Research-National Aerospace Laboratories, HAL Airport Road, Kodihalli, Bangalore 560017, India. Electronic address: aruna_reddy@nal.res.in.
S T
ST
Aruna
Structural Technologies Division, Council of Scientific and Industrial Research-National Aerospace Laboratories, HAL Airport Road, Kodihalli, Bangalore 560017, India.
S
S
Raja
D001672:Biocompatible Materials / Q000032:analysis*; D002460:Cell Line; D005030:Ethylenes; D006801:Humans; D008689:Methacrylates / Q000032:analysis*; D009985:Orthopedics; D011092:Polyethylene Glycols / Q000032:analysis*; D011108:Polymers / Q000032:analysis*; D013696:Temperature; D044366:Transition Temperature
D001672:Biocompatible Materials; D005030:Ethylenes; D008689:Methacrylates; D011108:Polymers; C421283:poly(ethylene glycol)-dimethacrylate; D011092:Polyethylene Glycols
Biocompatibility; Glass transition temperature; Shape memory polymer; Thermomechanical behavior