Synthesis of magnetic silica nanomarkers with controlled physicochemical properties.
Magnetic markers which can be detected with an extremely high sensitivity with the method of magnetic particle quantification (MPQ) were synthesized. Using a controlled Stober reaction, a set of magnetic silica markers of different sizes and zeta potentials was obtained. The use of a carboxymethyl dextran polymer to stabilize the magnetite particles during the synthesis made it possible to substantially reduce the detection limit of the obtained construct, which opens up new opportunities for creating effective diagnostic nanoagents.
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow, 117997, Russia. zelepukin@phystech.edu.|Nizhny Novgorod State University, pr. Gagarina 23, Nizhny Novgorod, 630600, Russia. zelepukin@phystech.edu.|Moscow Institute of Physics and Technology (State University), Institutskii per. 9, Dolgoprudnyi, Moscow oblast, 141700, Russia. zelepukin@phystech.edu.
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Zelepukin
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow, 117997, Russia.|Moscow Institute of Physics and Technology (State University), Institutskii per. 9, Dolgoprudnyi, Moscow oblast, 141700, Russia.|Prokhorov Institute of General Physics, Russian Academy of Sciences, ul. Vavilova 38, Moscow, 119991, Russia.
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Nikitin
Moscow Institute of Physics and Technology (State University), Institutskii per. 9, Dolgoprudnyi, Moscow oblast, 141700, Russia.
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Cherkasov
Prokhorov Institute of General Physics, Russian Academy of Sciences, ul. Vavilova 38, Moscow, 119991, Russia.
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Nikitin
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow, 117997, Russia.|Nizhny Novgorod State University, pr. Gagarina 23, Nizhny Novgorod, 630600, Russia.
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Deyev
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow, 117997, Russia.
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Petrov
D019343:Citric Acid / Q000737:chemistry; D003911:Dextrans / Q000737:chemistry; D000067493:Dynamic Light Scattering; D057446:Hydrodynamics; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission; D010316:Particle Size; D012822:Silicon Dioxide / Q000138:chemical synthesis / Q000737:chemistry*
D003911:Dextrans; D058185:Magnetite Nanoparticles; D019343:Citric Acid; D012822:Silicon Dioxide; C014392:carboxymethyl dextran