N-Halamine-Containing Electrospun Fibers Kill Bacteria via a Contact/Release Co-Determined Antibacterial Pathway.
N-Halamine-based antibacterial materials play a significant role in controlling microbial contamination, but their practical applications are limited because of their complicated synthetic process and indistinct antibacterial actions. In this study, novel antibacterial N-halamine-containing polymer fibers were synthesized via an one-step electrospinning of N-halamine-containing polymers without any additives. By adjusting the concentration of precursor and the molecular weight of polymers, the morphology and size of the as-spun N-halamine-containing fibers can be regulated. The as-spun fibers showed antibacterial activity against both Gram-positive and Gram-negative bacteria. After an antibacterial assessment using different biochemical techniques, a combined mechanism of contact/release co-determined killing action was evidenced for the as-spun N-halamine-containing fibers. With the aid of contact action and/or release action, this combined mechanism can allow N-halamines to attack bacteria, making the as-spun fibers wide in the application of antibacterial fields, whatever it is in dry or wet environment. Also, a recycle antibacterial test demonstrated that the as-spun fibers can still offer antibacterial property after five recycle experiments.
College of Chemistry and Chemical Engineering, Inner Mongolia University , Hohhot 010021, People's Republic of China.
Rong
R
Bai
Department of Chemistry, Tangshan Normal University , Tangshan 063000, People's Republic of China.
Qing
Q
Zhang
Affiliated Hospital of Inner Mongolia, University for the Nationalities , Tongliao 028000, People's Republic of China.
Lanlan
L
Li
College of Chemistry, Jilin University , Changchun 130021, People's Republic of China.
Ping
P
Li
Department of Chemical and Biological Engineering, University of British Columbia , 2360 East Mall, Vancouver, BC, Canada , V6T 1Z3.
Yan-Jie
YJ
Wang
Département de Chimie, Faculté Des Sciences (FDS), Université de Lomé (UL) , BP 1515 Lome, Togo.
Oudjaniyobi
O
Simalou
College of Chemistry and Chemical Engineering, Inner Mongolia University , Hohhot 010021, People's Republic of China.
Yanling
Y
Zhang
College of Chemistry, Jilin University , Changchun 130021, People's Republic of China.
Ge
G
Gao
College of Chemistry and Chemical Engineering, Inner Mongolia University , Hohhot 010021, People's Republic of China.|State Key Laboratory of Medicinal Chemical Biology, NanKai University , Tianjin 300071, People's Republic of China.
Alideertu
A
Dong
D000588:Amines; D000900:Anti-Bacterial Agents / Q000737:chemistry*; D004926:Escherichia coli; D008826:Microbial Sensitivity Tests; D013211:Staphylococcus aureus
D000588:Amines; D000900:Anti-Bacterial Agents
N-halamines; antibacterial; contact killing; electrospun; mechanism; release killing