Androgen deprivation therapy with Leuprolide acetate for treatment of advanced prostate cancer.
Hormone sensitive advanced prostate cancer (PCa) is an incurable disease that is treated with a variety of hormonal therapies targeting the androgen/androgen receptor signaling axis. For decades androgen deprivation therapy (ADT) by surgical or chemical castration is the gold standard for the treatment of advanced PCa. Areas covered: This review discusses the pharmacological features of Leuprolide, a luteinizing hormone-releasing hormone (LHRH) agonists/analog and the most commonly used drug in ADT. Expert opinion: Although Leuprolide has been on the market for more than 30 years it is still the leading option for ADT and serves as a basis for most multimodal therapy concepts. The fact that with the onset of castration-resistance in late stage metastatic disease, a prolongation of ADT in combination with a second line hormonal manipulation is recommended supports the importance of the compound for daily clinical practice.
a Department of Urology , University Clinic of Schleswig-Holstein , Lübeck , Germany.
M Raschid
MR
Hoda
a Department of Urology , University Clinic of Schleswig-Holstein , Lübeck , Germany.
Mario W
MW
Kramer
a Department of Urology , University Clinic of Schleswig-Holstein , Lübeck , Germany.
Axel S
AS
Merseburger
a Department of Urology , University Clinic of Schleswig-Holstein , Lübeck , Germany.
Marcus V
MV
Cronauer
D000726:Androgen Antagonists / Q000627:therapeutic use; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists; D006801:Humans; D016729:Leuprolide / Q000627:therapeutic use*; D008297:Male; D009919:Orchiectomy; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000188:drug therapy*
D000726:Androgen Antagonists; D018931:Antineoplastic Agents, Hormonal; D007987:Gonadotropin-Releasing Hormone; D016729:Leuprolide
Adverse events; Androgen deprivation therapy; Leuprolide acetate; Metastatic disease; Prostate cancer