Computational Biomechanics of Human Red Blood Cells in Hematological Disorders.
We review recent advances in multiscale modeling of the biomechanical characteristics of red blood cells (RBCs) in hematological diseases, and their relevance to the structure and dynamics of defective RBCs. We highlight examples of successful simulations of blood disorders including malaria and other hereditary disorders, such as sickle-cell anemia, spherocytosis, and elliptocytosis.
Division of Applied Mathematics, Brown University, Providence, RI 02912 e-mail: Xuejin_Li@brown.edu.
Xuejin
X
Li
Division of Applied Mathematics, Brown University, Providence, RI 02912.
He
H
Li
Division of Applied Mathematics, Brown University, Providence, RI 02912.
Hung-Yu
HY
Chang
Department of Mechanical Engineering, University of Connecticut, Storrs, CT 06269;Department of Biomedical Engineering, University of Connecticut, Storrs, CT 06269.
George
G
Lykotrafitis
Fellow ASME Division of Applied Mathematics, Brown University, Providence, RI 02912 e-mail: George_Karniadakis@brown.edu.
George
G
Em Karniadakis
D001783:Blood Flow Velocity; D048429:Cell Size; D019245:Compressive Strength; D003198:Computer Simulation; D055119:Elastic Modulus; D004912:Erythrocytes / Q000502:physiology*; D006402:Hematologic Diseases / Q000097:blood* / Q000503:physiopathology*; D006801:Humans; D008955:Models, Cardiovascular; D012212:Rheology / Q000379:methods; D033081:Shear Strength; D013314:Stress, Mechanical; D013718:Tensile Strength