Recent Advances of Metallocenes for Medicinal Chemistry.
BACKGROUND
The recent advances for the synthesis and application of different metallocenes for Medicinal Chemistry is reviewed.


OBJECTIVE
This manuscript presents the different metallocene scaffolds, with special emphasis on ferrocene derivatives, and their potential pharmaceutical application. Over the last years, the synthesis of new metallocene compounds and their biological and medicinal effects against some types of diseases (e.g. anti-tumoral, antibiotics, anti-viral) have been reported. From the medicinal point of view, the attractive properties of metallocene derivatives, such as their high stability, low toxicity and appealing redox behaviors are particularly relevant.


RESULTS
This area has attracted many researchers as well as the pharmaceutical industry due to the promising results of some metallocenes, in particular ferrocene compounds, in breast cancer and malaria.
LAQV-REQUIMTE, Chemistry Department, Faculty of Science and Technology, Universidade NOVA de Lisboa, P.O. Box: 2829-516, Portugal.
Miguel M
MM
Santos
LAQV-REQUIMTE, Chemistry Department, Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa, Campus da FCT/UNL, Portugal.
Pedro
P
Bastos
LAQV-REQUIMTE, Chemistry Department, Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa, Campus da FCT/UNL, Portugal.
Isabelle
I
Catela
LAQV-REQUIMTE, Chemistry Department, Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa, Campus da FCT/UNL, Portugal.
Karolina
K
Zalewska
LAQV-REQUIMTE, Chemistry Department, Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa, Campus da FCT/UNL, Portugal.
Luis C
LC
Branco
D000818:Animals; D019380:Anti-HIV Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000962:Antimalarials / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002626:Chemistry, Pharmaceutical; D005260:Female; D006678:HIV / Q000187:drug effects*; D006801:Humans; D008288:Malaria / Q000188:drug therapy*; D009369:Neoplasms / Q000188:drug therapy*; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use*
D019380:Anti-HIV Agents; D000962:Antimalarials; D000970:Antineoplastic Agents; D009942:Organometallic Compounds; C013108:metallocene
Anti-HIV; anti-malaria; anti-tumoral; ferrocene derivatives; medicinal chemistry; metallocenes