Neuronal surface antibodies in HIV-infected patients with isolated psychosis.
Neuronal surface antibodies (NSA) involved in autoimmune encephalitis (AE) have been related to relapses in HVS encephalitis. Their role in non-encephalitic psychosis is controversial. We previously reported an HIV-infected patient, NSA-positive, only presenting psychosis. Therefore, we determined the NSA prevalence in a prospective cohort of 22 HIV-positive patients with psychosis and we analyzed the frequency of HIV infection among NSA tested patients due to AE suspicion. We found no NSA in the prospective cohort. In the retrospective analysis, 22% of NSA-positive versus 4.6% of negative patients were HIV-positive. Wider studies are required to clarify the relationship between NSA and HIV infection.
Department of Immunology, Hospital Universitari Son Espases, Carretera de Valldemossa 79, 07120, Palma de Mallorca, Spain; Institut d'Investigacio Sanitaria de Palma (IdISPa), Spain.
Vanessa
V
Cunill
Department of Psychiatry, Hospital Universitari Son Espases, Carretera de Valldemossa 79, 07120, Palma de Mallorca, Spain; Faculty of Medicine, Universitat de Barcelona, Carrer de Casanova 143, 08036 Barcelona, Spain.
Susana
S
Arboleya
Department of Immunology, Hospital Universitari Son Espases, Carretera de Valldemossa 79, 07120, Palma de Mallorca, Spain; Institut d'Investigacio Sanitaria de Palma (IdISPa), Spain. Electronic address: rosa.julia@ssib.es.
Maria de Los Reyes
ML
Jiménez
Institut d'Investigacio Sanitaria de Palma (IdISPa), Spain; Department of Internal Medicine, Hospital Universitari Son Espases, Carretera de Valldemossa 79, 07120, Palma de Mallorca, Spain.
Antoni
A
Campins
Institut d'Investigacio Sanitaria de Palma (IdISPa), Spain; Department of Psychiatry, Hospital Universitari Son Espases, Carretera de Valldemossa 79, 07120, Palma de Mallorca, Spain.
Patricia
P
Herbera
Institut d'Investigacio Sanitaria de Palma (IdISPa), Spain; Department of Psychiatry, Hospital Universitari Son Espases, Carretera de Valldemossa 79, 07120, Palma de Mallorca, Spain.
LLuïsa
L
Mestre
Department of Immunology, Hospital Universitari Son Espases, Carretera de Valldemossa 79, 07120, Palma de Mallorca, Spain; Institut d'Investigacio Sanitaria de Palma (IdISPa), Spain.
Antonio
A
Clemente
Department of Neurology, Hospital Universitari Son Espases, Carretera de Valldemossa 79, 07120, Palma de Mallorca, Spain.
Maria Inés
MI
Barceló
Institut d'Investigacio Sanitaria de Palma (IdISPa), Spain; Department of Internal Medicine, Hospital Universitari Son Espases, Carretera de Valldemossa 79, 07120, Palma de Mallorca, Spain.
Maria
M
Leyes
Institut d'Investigacio Sanitaria de Palma (IdISPa), Spain; Department of Psychiatry, Hospital Universitari Son Espases, Carretera de Valldemossa 79, 07120, Palma de Mallorca, Spain.
Francesca
F
Canellas
Department of Immunology, Hospital Universitari Son Espases, Carretera de Valldemossa 79, 07120, Palma de Mallorca, Spain; Institut d'Investigacio Sanitaria de Palma (IdISPa), Spain.
Maria Rosa
MR
Julià
D000328:Adult; D000906:Antibodies / Q000097:blood*; D015331:Cohort Studies; D005260:Female; D057809:HEK293 Cells; D015658:HIV Infections / Q000097:blood / Q000150:complications / Q000276:immunology; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000276:immunology*; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000276:immunology*; D009474:Neurons / Q000378:metabolism*; D011618:Psychotic Disorders / Q000097:blood / Q000150:complications / Q000276:immunology; D014162:Transfection
D000906:Antibodies; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins
HIV infection; Neuronal surface antibodies; Psychosis