Clinical audit of estradiol implant therapy: Long duration of action and implications in non-hysterectomised women.
We audited the files of 114 postmenopausal women who had been treated with subcutaneous Estrapel (50mg oestradiol implants). Of the 92 women who received more than one implant, the median number of days between implants was 223.5 (range 49-875), with an estimated median time to return to baseline of 311days (range 108-1228). Although oestradiol implants can provide an excellent non-oral treatment option, their prolonged action makes patient selection important, as the implants cannot easily be removed. In women with an intact uterus, the continuation of progestin therapy after cessation of implant therapy is imperative.
The Women's Health Research Program, School of Public Health and Preventive Medicine, Monash University, Level 6 The Alfred Centre, 99 Commercial Road, Melbourne,Victoria, 3004, Australia.
Shaday
S
Wheatley
The Women's Health Research Program, School of Public Health and Preventive Medicine, Monash University, Level 6 The Alfred Centre, 99 Commercial Road, Melbourne,Victoria, 3004, Australia.
Robin J
RJ
Bell
Keogh Institute for Medical Research, Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, School of Medicine and Pharmacology, University of Western Australia, Nedlands WA 6009, Australia.
Bronwyn G A
BG
Stuckey
The Women's Health Research Program, School of Public Health and Preventive Medicine, Monash University, Level 6 The Alfred Centre, 99 Commercial Road, Melbourne,Victoria, 3004, Australia.
Penelope J
PJ
Robinson
The Women's Health Research Program, School of Public Health and Preventive Medicine, Monash University, Level 6 The Alfred Centre, 99 Commercial Road, Melbourne,Victoria, 3004, Australia. Electronic address: susan.davis@monash.edu.
Susan R
SR
Davis
D054869:Clinical Audit; D004343:Drug Implants; D004958:Estradiol / Q000008:administration & dosage / Q000627:therapeutic use*; D015914:Estrogen Replacement Therapy / Q000379:methods*; D005260:Female; D006801:Humans; D008875:Middle Aged; D017698:Postmenopause; D012189:Retrospective Studies; D013997:Time Factors
D004343:Drug Implants; D004958:Estradiol
Hormone implant; Menopausal hormone therapy; Oestradiol