Running during adolescence rescues a maternal separation-induced memory impairment in female mice: Potential role of differential exon-specific BDNF expression.
Exposure to early life stress has been associated with memory impairments related to changes in brain-derived neurotrophic factor (BDNF) signaling. However, the potential impact of physical exercise to reverse these effects of maternal separation has been under investigated. Mice were subjected to maternal separation during the first 2 weeks of life and then exposed to a 3-week running protocol during adolescence. The spontaneous object recognition task was performed during adolescence followed by analysis of hippocampal expression of exons I, IV, and IX of the BDNF gene. As expected, maternal separation impaired recognition memory and this effect was reversed by exercise. In addition, running increased BDNF exon I expression, but decreased expression of BDNF exon IV in all groups, while exon IX expression increased only in MS animals exposed to exercise. Our data suggest that memory deficits can be attenuated by exercise and specific transcripts of the BDNF gene are dynamically regulated following both MS and exercise.
Graduate Program in Pediatrics and Child Health, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, Rio Grande do Sul, Brazil.|Developmental Cognitive Neuroscience Laboratory (DCNL) Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, Brazil.
Luis Eduardo
LE
Wearick-Silva
Department of Neurobiology and Behavior, University of California - Irvine, Irvine, California.
Paul
P
Marshall
Graduate Program in Pediatrics and Child Health, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, Rio Grande do Sul, Brazil.|Developmental Cognitive Neuroscience Laboratory (DCNL) Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, Brazil.
Thiago Wendt
TW
Viola
Graduate Program in Pediatrics and Child Health, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, Rio Grande do Sul, Brazil.|Developmental Cognitive Neuroscience Laboratory (DCNL) Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, Brazil.
Anderson
A
Centeno-Silva
Graduate Program in Pediatrics and Child Health, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, Rio Grande do Sul, Brazil.|Developmental Cognitive Neuroscience Laboratory (DCNL) Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, Brazil.
Lucas Araújo
LA
de Azeredo
Graduate Program in Pediatrics and Child Health, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, Rio Grande do Sul, Brazil.|Developmental Cognitive Neuroscience Laboratory (DCNL) Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, Brazil.
Rodrigo
R
Orso
Department of Neurobiology and Behavior, University of California - Irvine, Irvine, California.
Xiang
X
Li
Graduate Program in Pediatrics and Child Health, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, Rio Grande do Sul, Brazil.
Márcio V
MV
Donadio
Department of Neurobiology and Behavior, University of California - Irvine, Irvine, California.
Timothy W
TW
Bredy
Graduate Program in Pediatrics and Child Health, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, Rio Grande do Sul, Brazil.|Developmental Cognitive Neuroscience Laboratory (DCNL) Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, Brazil.
Rodrigo
R
Grassi-Oliveira
D000367:Age Factors; D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism*; D005091:Exons; D005260:Female; D006624:Hippocampus / Q000378:metabolism*; D008297:Male; D008426:Maternal Deprivation; D008569:Memory Disorders / Q000209:etiology / Q000628:therapy*; D051379:Mice; D008807:Mice, Inbred BALB C; D010805:Physical Conditioning, Animal; D021641:Recognition, Psychology / Q000502:physiology*
D019208:Brain-Derived Neurotrophic Factor
BDNF; adolescence; early life stress; exercise; memory; mice