Signaling targets of alcoholic intoxication in human skeletal muscle.
Intracellular signaling pathways were investigated in skeletal muscle cells at the early stages of alcohol addiction manifestations. No muscle fiber atrophy was observed in m. vastus lateralis of male patients. No significant changes in the signaling mechanisms that control protein degradation were detected as well. However, the concentration of the insulin-like growth factor (IGF-1) in blood plasma as well as the content of markers of intracellular signaling pathways regulating protein synthesis were significantly reduced compared to the control group.
Institute of Biomedical Problems, Russian Academy of Sciences, Khoroshevskoe sh. 76-a, Moscow, 123007, Russia.
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Mirzoev
Institute of Biomedical Problems, Russian Academy of Sciences, Khoroshevskoe sh. 76-a, Moscow, 123007, Russia.
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Lomonosova
Sechenov First Moscow State Medical University, Ministry of Health Care of the Russian Federation, Moscow, Russia.
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Zinovyeva
Institute of Biomedical Problems, Russian Academy of Sciences, Khoroshevskoe sh. 76-a, Moscow, 123007, Russia.
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Lysenko
Institute of Biomedical Problems, Russian Academy of Sciences, Khoroshevskoe sh. 76-a, Moscow, 123007, Russia.
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Shenkman
Institute of Biomedical Problems, Russian Academy of Sciences, Khoroshevskoe sh. 76-a, Moscow, 123007, Russia. nemirovskaya@bk.ru.|Moscow State University, Moscow, 119234, Russia. nemirovskaya@bk.ru.
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Nemirovskaya
D000435:Alcoholic Intoxication / Q000378:metabolism* / Q000473:pathology; D000437:Alcoholism / Q000378:metabolism* / Q000473:pathology; D000704:Analysis of Variance; D001284:Atrophy; D054736:Elongation Factor 2 Kinase / Q000378:metabolism; D006801:Humans; D055504:Insulin Receptor Substrate Proteins / Q000378:metabolism; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D018485:Muscle Fibers, Skeletal / Q000378:metabolism* / Q000473:pathology; D010766:Phosphorylation; D059748:Proteolysis / Q000187:drug effects; D012333:RNA, Messenger / Q000378:metabolism; D038762:Ribosomal Protein S6 Kinases, 70-kDa / Q000378:metabolism; D038744:Ribosomal Protein S6 Kinases, 90-kDa / Q000378:metabolism
C583557:IGF1 protein, human; C526292:IRS1 protein, human; D055504:Insulin Receptor Substrate Proteins; D012333:RNA, Messenger; D007334:Insulin-Like Growth Factor I; C517689:EEF2K protein, human; D038762:Ribosomal Protein S6 Kinases, 70-kDa; D038744:Ribosomal Protein S6 Kinases, 90-kDa; D054736:Elongation Factor 2 Kinase