A new phenolic glycoside from Lindera nacusua.
The present study was designed to investigate the chemical constituents of Lindera nacusua and their antitumor activities. A new phenolic glycoside, namely 1-O-3-hydroxyphenyl-5-methoxyphenol-(6'-O-vanilloyl)-β-d-glucopyranoside (1), together with five known phenolic glycosides (2-6), two anthraquinones (7, 8) and two γ-butanolides (9, 10), was isolated, and its structure was elucidated by spectroscopic and chemical methods. Compounds 1-10 were screened for their in vitro cytotoxicities against HL-60, SMMC-7721, A549, MCF-3 and SW480 cell lines by the MTS method. Compounds 9 and 10 showed moderate cytotoxicities with IC50values ranging from 17.40 to 35.21 μM.
a School of Life Science and Engineering , Southwest Jiaotong University , Chengdu , P.R. China.
Jie-Ping
JP
Lei
a School of Life Science and Engineering , Southwest Jiaotong University , Chengdu , P.R. China.
Guo-Qing
GQ
Wei
a School of Life Science and Engineering , Southwest Jiaotong University , Chengdu , P.R. China.
Juan-Juan
JJ
Yuan
a School of Life Science and Engineering , Southwest Jiaotong University , Chengdu , P.R. China.
Kang-Zhi
KZ
Tan
a School of Life Science and Engineering , Southwest Jiaotong University , Chengdu , P.R. China.
Qiao-Yu
QY
Chen
b Department of Oncology , Chengdu Military General Hospital , Chengdu , P.R. China.
Tao
T
Zhang
a School of Life Science and Engineering , Southwest Jiaotong University , Chengdu , P.R. China.
Chao-Ying
CY
Ma
a School of Life Science and Engineering , Southwest Jiaotong University , Chengdu , P.R. China.
He-Zhong
HZ
Jiang
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D018922:HL-60 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D027443:Lindera / Q000737:chemistry*; D015394:Molecular Structure; D009005:Monosaccharides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010636:Phenols / Q000737:chemistry / Q000494:pharmacology; D018547:Plant Stems / Q000737:chemistry
C000619345:1-O-3-hydroxyphenyl-5-methoxyphenol-(6'-O-vanilloyl)-beta-D-glucopyranoside; D000972:Antineoplastic Agents, Phytogenic; D006027:Glycosides; D009005:Monosaccharides; D010636:Phenols
Lindera nacusua; cytotoxicity; phenolic glycoside; γ-butanolide