The utility of adipose-derived stem cells and stromal vascular fraction for oncologic soft tissue reconstruction: Is it safe? A matter for debate.
Autologous free-fat grafting (AFG) has emerged as an attractive proposition for soft-tissue reconstruction of various contour defects because it obviates more complex reconstructive options and reduces operative times and donor-site morbidity. Nonetheless, a common complication of this procedure is the resorption of the engrafted fat. Cell-assisted lipotransfer (CAL) is now a well-regarded technique where adipose-derived stem cell (ASC)-rich stromal vascular fraction is admixed with lipoaspirate, increasing the volumetric outcome of fat grafts in light of its potent angiogenic and adipogenic properties. Criticisms, however, remain regarding this modality especially for the treatment of post-oncologic defects. Laboratory data has attested to its propensity to perpetuate tumor cells as a result of its paracrine effects on the host microenvironment. This review article aims to present the underlying facts behind ASC therapy and provide meaningful discourse as to its utility in post-oncologic soft tissue reconstruction.
Department of General Surgery, Section of Plastic Reconstructive and Aesthetic Surgery, Tan Tock Seng Hospital, Singapore. Electronic address: shaunnietan@hotmail.com.
Shaun S
SS
Tan
Department of General Surgery, Singapore General Hospital, Singapore.
Weiliang
W
Loh
D006801:Humans; D015187:Lipectomy; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods*; D019651:Plastic Surgery Procedures / Q000379:methods*; D012983:Soft Tissue Neoplasms / Q000601:surgery*; D050151:Subcutaneous Fat / Q000166:cytology / Q000637:transplantation*
Fat grafting; Regenerative medicine; Soft tissue reconstruction; Stem cell therapy