Association of prostate volume with incidence and aggressiveness of prostate cancer.
OBJECTIVE
The aim of this study was to investigate the possible correlation between prostate volume and aggressiveness and incidence of prostate cancer (PCa).


METHODS
A chart review of a cohort of 448 consecutive prostate biopsy-naive men was performed. These men underwent at least a 12-core biopsy at our institution due to increased prostate-specific antigen serum levels (>4 ng/mL) and/or suspicious findings on digital rectal examination during the period between 2008 and 2013. Transrectal ultrasound was used to determine the prostate volume.


RESULTS
The positive biopsy rate was 66% for patients with a prostate volume of ≤35 cc and 40% for patients with a prostate volume of ≥65 cc (P<0.001). Of the 110 patients testing positive on biopsy with a volume of ≤35 cc, 10 patients (9.1%) had a Gleason score of ≥8. Of the 27 patients testing positive on biopsy with a volume of ≥65 cc, only 1 patient (3.7%) had a Gleason score of ≥8.


CONCLUSIONS
These results suggest that there may be an association between prostate volume and the incidence and aggressiveness of PCa. The larger the prostate, the lower the positive biopsy rate for PCa and the lower the Gleason score.
Department of Urology, Texas Tech University Health Sciences Center, Lubbock, TX, USA.
Shadi
S
Al-Khalil
Department of Urology, Texas Tech University Health Sciences Center, Lubbock, TX, USA.
Christine
C
Ibilibor
Department of Urology, Texas Tech University Health Sciences Center, Lubbock, TX, USA.
James Thomas
JT
Cammack
Department of Urology, Texas Tech University Health Sciences Center, Lubbock, TX, USA.
Werner
W
de Riese
prostate cancer; prostate volume; prostate-specific antigen