Elevated expression of thyroid hormone receptor-interacting protein 13 drives tumorigenesis and affects clinical outcome.
OBJECTIVE
To investigate the expression of TRIP13 in multiple tumors and to evaluate the relationship between TRIP13 and survival of cancer patients.


METHODS
Sample expression profiles were downloaded from the gene expression omnibus database. Correlation between TRIP13 expression and clinicopathological features was analyzed by χ2test. Patient survival was evaluated by Kaplan-Meier analysis.


RESULTS
TRIP13 expression was upregulated in 12 cancer types; it significantly correlated with multiple clinicopathological features of breast, liver and lung cancer. High TRIP13 expression indicated poor prognosis of patients with breast, liver, gastric and lung cancer.


CONCLUSIONS
TRIP13 is highly expressed in multiple tumors and may be used as a potential prognostic marker and therapeutic target.
Qingdao Municipal Hospital, School of Medicine, Qingdao University, No. 5 Donghai Middle Road, Qingdao, Shandong Province, 266071, China.|School of Basic Medicine, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430030, China.
Wang
W
Dazhi
Qingdao Municipal Hospital, School of Medicine, Qingdao University, No. 5 Donghai Middle Road, Qingdao, Shandong Province, 266071, China.
Zhang
Z
Mengxi
School of Basic Medicine, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430030, China.
Chen
C
Fufeng
Qingdao Municipal Hospital, School of Medicine, Qingdao University, No. 5 Donghai Middle Road, Qingdao, Shandong Province, 266071, China.
Yan
Y
Meixing
D000074183:ATPases Associated with Diverse Cellular Activities; D000368:Aged; D000465:Algorithms; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism*; D018797:Cell Cycle Proteins; D030541:Databases, Genetic; D018450:Disease Progression; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009369:Neoplasms / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology; D011379:Prognosis; D015854:Up-Regulation
D014408:Biomarkers, Tumor; D002352:Carrier Proteins; D018797:Cell Cycle Proteins; D000074183:ATPases Associated with Diverse Cellular Activities; C575259:TRIP13 protein, human
cancer biomarkers; poor prognosis; thyroid hormone receptor-interacting protein 13