Alvimopan for post-operative ileus: What we should know?
Alvimopan is an US-FDA approved, peripherally acting mu opioid receptor antagonist which when started pre-operatively has been shown to hasten intestinal motility and reduce the duration of post-operative ileus. However the logistics involved in procuring, storing and dispensing the drug and the cost of the drug for fifteen doses as approved by FDA prohibits the use of it on a regular basis.
Basavatarakam Indo-American Cancer Hospital and Research Institute, Road No. 10, Banjara Hills, Hyderabad 500034, India. Electronic address: abhijitnair95@gmail.com.
Abhijit
A
Nair
D006801:Humans; D045823:Ileus / Q000188:drug therapy*; D010880:Piperidines / Q000627:therapeutic use*; D011183:Postoperative Complications / Q000188:drug therapy*; D017450:Receptors, Opioid, mu / Q000037:antagonists & inhibitors*
D010880:Piperidines; D017450:Receptors, Opioid, mu; C419502:alvimopan
Alvimopan; Colorectal Surgery; Ileus