Early detection of cardiac involvement in sarcoidosis with 2-dimensional speckle-tracking echocardiography.
OBJECTIVE
Cardiac sarcoidosis (CS) is associated with high morbidity and sudden death. The absence of specific symptoms and lack of diagnostic gold standard technique is challenging. New imaging methods could improve the diagnosis of CS. The aim of our study was to assess the role of left ventricular (LV) longitudinal and circumferential strain as estimated by 2D speckle-tracking imaging in patients with diagnosed sarcoidosis without cardiac involvement according to the current guidelines. We investigated the prevalence of LV strain impairment in this population and assessed its relationship with clinical outcomes, composite of mortality, heart failure, arrhythmia and/or secondarily development of CS and cardiac device implantation.


RESULTS
We performed a prospective case-control longitudinal study including 35 patients with diagnosed sarcoidosis and normal cardiac function as assessed by standard transthoracic echocardiography and 35 healthy age- and gender-matched controls. All patients underwent a comprehensive echocardiographic study. Mean age of patients was 47.9±14.8years old (22 women). Compared with controls, global LV longitudinal strain (LV GLS) was reduced in sarcoidosis patients: (-17.2±3.1 vs -21.3±1.5%, p<0.0001). Circumferential LV strain was preserved in patients compared to controls (-19.9±-4.3% vs -21.3±1.5%, p=0.12). Impaired LV GLS was significantly associated with clinical outcomes (HR 1.56; [1.16-2.11], p<0.01) on univariate analysis.


CONCLUSIONS
Speckle-tracking echocardiography revealed decreased longitudinal LV strain in sarcoidosis patients that was associated with outcomes. LV GLS may represent an early marker of myocardial involvement in sarcoidosis patients that needs to be studied further.
Cardiology Department, Hôpital Pasteur, CHU de Nice, Nice, France.
Elie-Dan
ED
Schouver
Cardiology Department, Hôpital Pasteur, CHU de Nice, Nice, France. Electronic address: moceri.p@chu-nice.fr.
Pamela
P
Moceri
Medical Intensive Care Unit, Hôpital L'Archet, CHU de Nice, Nice, France.
Denis
D
Doyen
Internal medicine Department, Hôpital L'Archet, CHU de Nice, Nice, France.
Nathalie
N
Tieulie
Internal medicine Department, Hôpital L'Archet, CHU de Nice, Nice, France.
Viviane
V
Queyrel
Cardiology Department, Hôpital Pasteur, CHU de Nice, Nice, France.
Delphine
D
Baudouy
Cardiology Department, Hôpital Pasteur, CHU de Nice, Nice, France.
Pierre
P
Cerboni
Cardiology Department, Hôpital Pasteur, CHU de Nice, Nice, France.
Pierre
P
Gibelin
Respiratory medicine Department, Hôpital Pasteur, CHU de Nice, Nice, France.
Sylvie
S
Leroy
Internal medicine Department, Hôpital L'Archet, CHU de Nice, Nice, France.
Jean-Gabriel
JG
Fuzibet
Cardiology Department, Hôpital Pasteur, CHU de Nice, Nice, France.
Emile
E
Ferrari
D000328:Adult; D009202:Cardiomyopathies / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D016022:Case-Control Studies; D042241:Early Diagnosis; D004452:Echocardiography / Q000639:trends*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012507:Sarcoidosis / Q000000981:diagnostic imaging* / Q000503:physiopathology*
Cardiac sarcoidosis; Echocardiography; Speckle-tracking imaging