The Quid Pro Quo of the Tumor/Stromal Interaction.
Cancers can derive metabolic support from the stromal cells that surround them. A new study in Cell Metabolism (Yang et al., 2016) describes how ovarian cancer cells can satisfy their need for glutamine by stimulating glutamine production in adjacent fibroblasts, highlighting a metabolic dependence that might be targeted for therapy.
CRUK Beatson Institute, Switchback Road, Glasgow G61 1BD, UK.
Mylène
M
Tajan
CRUK Beatson Institute, Switchback Road, Glasgow G61 1BD, UK. Electronic address: k.vousden@beatson.gla.ac.uk.
Karen H
KH
Vousden
D051242:Caveolin 1; D005347:Fibroblasts; D005973:Glutamine; D006801:Humans; D009369:Neoplasms; D017154:Stromal Cells
D051242:Caveolin 1; D005973:Glutamine