Comparison of unsupervised classification methods for brain tumor segmentation using multi-parametric MRI.
Tumor segmentation is a particularly challenging task in high-grade gliomas (HGGs), as they are among the most heterogeneous tumors in oncology. An accurate delineation of the lesion and its main subcomponents contributes to optimal treatment planning, prognosis and follow-up. Conventional MRI (cMRI) is the imaging modality of choice for manual segmentation, and is also considered in the vast majority of automated segmentation studies. Advanced MRI modalities such as perfusion-weighted imaging (PWI), diffusion-weighted imaging (DWI) and magnetic resonance spectroscopic imaging (MRSI) have already shown their added value in tumor tissue characterization, hence there have been recent suggestions of combining different MRI modalities into a multi-parametric MRI (MP-MRI) approach for brain tumor segmentation. In this paper, we compare the performance of several unsupervised classification methods for HGG segmentation based on MP-MRI data including cMRI, DWI, MRSI and PWI. Two independent MP-MRI datasets with a different acquisition protocol were available from different hospitals. We demonstrate that a hierarchical non-negative matrix factorization variant which was previously introduced for MP-MRI tumor segmentation gives the best performance in terms of mean Dice-scores for the pathologic tissue classes on both datasets.
KU Leuven, Department of Electrical Engineering (ESAT), STADIUS Centre for Dynamical Systems, Signal Processing and Data Analytics, Leuven, Belgium; iMinds, Department of Medical Information Technologies, Belgium.
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Sauwen
Ghent University Hospital, Department of Radiology, Ghent, Belgium.
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M
Acou
University Hospitals of Leuven, Department of Radiology, Leuven, Belgium; Ziekenhuizen Oost-Limburg, Department of Radiology, Leuven, Belgium.
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Van Cauter
KU Leuven, Department of Electrical Engineering (ESAT), STADIUS Centre for Dynamical Systems, Signal Processing and Data Analytics, Leuven, Belgium; iMinds, Department of Medical Information Technologies, Belgium.
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Sima
University of Antwerp, iMinds Vision Lab, Department of Physics, Antwerp, Belgium.
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Veraart
KU Leuven, Department of Electrical Engineering (ESAT), PSI Centre for Processing Speech and Images, Leuven, Belgium.
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Maes
KU Leuven, Biomedical MRI/MoSAIC, Department of Imaging and Pathology, Leuven, Belgium.
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Himmelreich
Ghent University Hospital, Department of Radiology, Ghent, Belgium.
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Achten
KU Leuven, Department of Electrical Engineering (ESAT), STADIUS Centre for Dynamical Systems, Signal Processing and Data Analytics, Leuven, Belgium; iMinds, Department of Medical Information Technologies, Belgium.
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Van Huffel
D001932:Brain Neoplasms / Q000145:classification / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology; D003627:Data Interpretation, Statistical; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods; D005910:Glioma / Q000145:classification / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods
1H MRSI, proton magnetic resonance spectroscopic imaging; ADC, apparent diffusion coefficient; Cho, total choline; Clustering; Cre, total creatine; DKI, diffusion kurtosis imaging; DSC-MRI, dynamic susceptibility-weighted contrast-enhanced magnetic resonance imaging; DTI, diffusion tensor imaging; DWI, diffusion-weighted imaging; FA, fractional anisotropy; FCM, fuzzy C-means clustering; FLAIR, fluid-attenuated inversion recovery; GBM, glioblastoma multiforme; GMM, Gaussian mixture modelling; Glioma; Glx, glutamine + glutamate; Gly, glycine; HALS, hierarchical alternating least squares; HGG, high-grade glioma; LGG, low-grade glioma; Lac, lactate; Lip, lipids; MD, mean diffusivity; MK, mean kurtosis; MP-MRI, multi-parametric magnetic resonance imaging; Multi-parametric MRI; NAA, N-acetyl-aspartate; NMF, non-negative matrix factorization; NNLS, non-negative linear least-squares; Non-negative matrix factorization; PWI, perfusion-weighted imaging; ROI, region of interest; SC, spectral clustering; SPA, successive projection algorithm; Segmentation; T1c, contrast-enhanced T1; UZ Gent, University hospital of Ghent; UZ Leuven, University hospitals of Leuven; Unsupervised classification; cMRI, conventional magnetic resonance imaging; hNMF, hierarchical non-negative matrix factorization; mI, myo-inositol; rCBV, relative cerebral blood volume