Clinical research of fenofibrate and spironolactone for acute central serous chorioretinopathy.
OBJECTIVE
To compare the effectiveness of combined fenofibrate and spironolactone with fenofibrate alone for treatment of central serous chorioretinopathy (CSCR).


METHODS
Totally 60 patients (60 eyes) with a history of acute CSCR were randomed into two groups: group A with combination of fenofibrate (200 mg) and spironolactone (100 mg), and group B with only fenofibrate (200 mg). They were taken half an hour before meals and once per day for 8wk. The changes of the visual acuity, subjective symptom, ocular surface disease index (OSDI), the tear film and optical coherence tomography were observed at 2, 4, 6, and 8wk before and after treatment.


RESULTS
The best corrected visual acuity (BCVA, logMAR) was improved to 0.22 and 0.27 after treatment from baseline of 0.35 and 0.36 in groups A and B (P<0.05), respectively. After 8wk treatment, the central subfield thickness (CST), and subretinal fluid volumn (SFV) decreased significantly to 49.5% and 78.8% in group A and 37.0% and 57.2% in group B. There were significant differences of CST and SFV in both groups (allP<0.05).


CONCLUSIONS
Fenofibrate combined with spironolactone may have more clinical efficacy in the treatment of CSCR than fenofibrate only.
Department of Ophthalmology, the First Affiliated Hosptal of Nanchang University, Jiangxi Province Clinical Ophthalmology Institute, Nanchang 330006, Jiangxi Province, China; Affiliated Eye Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China.
Yong
Y
Chai
Department of Ophthalmology, the First Affiliated Hosptal of Nanchang University, Jiangxi Province Clinical Ophthalmology Institute, Nanchang 330006, Jiangxi Province, China; Postgraduate College, the Third Hospital Affiliated of Sun Yat-sen University, Guangzhou 510000, Guangdong Province, China.
Rong-Qiang
RQ
Liu
Affiliated Eye Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China.
Jing-Lin
JL
Yi
Department of Ophthalmology, the First Affiliated Hosptal of Nanchang University, Jiangxi Province Clinical Ophthalmology Institute, Nanchang 330006, Jiangxi Province, China.
Ling-Hong
LH
Ye
Affiliated Eye Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China.
Jing
J
Zou
Department of Ophthalmology, the First Affiliated Hosptal of Nanchang University, Jiangxi Province Clinical Ophthalmology Institute, Nanchang 330006, Jiangxi Province, China.
Nan
N
Jiang
Department of Ophthalmology, the First Affiliated Hosptal of Nanchang University, Jiangxi Province Clinical Ophthalmology Institute, Nanchang 330006, Jiangxi Province, China.
Yi
Y
Shao
central serous chorioretinopathy; fenofibrate; optical coherence tomography; spironolactone; vision