The senescence accelerated mouse prone 8 (SAMP8): A novel murine model for cardiac aging.
Because cardiovascular disease remains the major cause of mortality and morbidity world-wide, there remains a compelling need for new insights and novel therapeutic avenues. In this regard, the senescence-accelerated mouse prone 8 (SAMP8) line is a particularly good model for studying the effects of aging on cardiovascular health. Accumulating evidence suggests that this model may shed light on age-associated cardiac and vascular dysfunction and disease. These animals manifest evidence of inflammation, oxidative stress and adverse cardiac remodeling that may recapitulate processes involved in human disease. Early alterations in oxidative damage promote endoplasmic reticulum stress to trigger apoptosis and cytokine production in this genetically susceptible mouse strain. Conversely, pharmacological treatments that reduce inflammation and oxidative stress improve cardiac function in these animals. Therefore, the SAMP8 mouse model provides an exciting opportunity to expand our knowledge of aging in cardiovascular disease and the potential identification of novel targets of treatment. Herein, we review the previous studies performed in SAMP8 mice that provide insight into age-related cardiovascular alterations.
Department of Clinical Pharmacology, Niigata University of Pharmacy and Applied Life Sciences, Niigata 956-8603, Japan.
Vengadeshprabhu
V
Karuppagounder
Department of Clinical Pharmacology, Niigata University of Pharmacy and Applied Life Sciences, Niigata 956-8603, Japan.
Somasundaram
S
Arumugam
Department of Cardiovascular Sciences, Houston Methodist Research Institute, Houston, TX 77030, USA.
Sahana Suresh
SS
Babu
Division of Hypertension and Vascular Research, Henry Ford Health System, Detroit, MI 48202, USA.
Suresh S
SS
Palaniyandi
Department of Clinical Pharmacology, Niigata University of Pharmacy and Applied Life Sciences, Niigata 956-8603, Japan.
Kenichi
K
Watanabe
Department of Cardiovascular Sciences, Houston Methodist Research Institute, Houston, TX 77030, USA.
John P
JP
Cooke
Department of Cardiovascular Sciences, Houston Methodist Research Institute, Houston, TX 77030, USA. Electronic address: ramirthalingamthandavarayan@houstonmethodist.org.
Rajarajan A
RA
Thandavarayan
D019588:Aging, Premature / Q000378:metabolism / Q000503:physiopathology; D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D002319:Cardiovascular System / Q000378:metabolism / Q000503:physiopathology; D016922:Cellular Senescence / Q000502:physiology*; D004195:Disease Models, Animal; D007249:Inflammation / Q000503:physiopathology*; D051379:Mice; D018384:Oxidative Stress / Q000502:physiology*
Aging; Cardiac remodeling; Inflammation; Oxidative stress; Senescence-accelerated prone mouse 8