Lipid-membrane-incorporated arylboronate esters as agents for boron neutron capture therapy.
Arylboronate esters bearing methyl groups in both of their ortho positions were stably incorporated into lipid membranes at high concentrations without undergoing hydrolysis to the corresponding boronic acids. This method could be used in combination with previous methods to increase the maximum ratio of boron atoms in liposomal boron carriers.
Department of Applied Chemistry, Graduate School of Engineering, Hiroshima University, 1-4-1 Higashi, Hiroshima 739-8527, Japan. aikeda@hiroshima-u.ac.jp.
Masafumi
M
Ueda
Kengo
K
Ashizawa
Kouta
K
Sugikawa
Kazuya
K
Koumoto
Takeshi
T
Nagasaki
Atsushi
A
Ikeda
D016754:Boron Neutron Capture Therapy; D001897:Boronic Acids / Q000737:chemistry*; D004952:Esters / Q000737:chemistry*; D006868:Hydrolysis; D008051:Lipid Bilayers / Q000737:chemistry*; D015394:Molecular Structure
D001897:Boronic Acids; D004952:Esters; D008051:Lipid Bilayers