Proteomics progresses in microbial physiology and clinical antimicrobial therapy.
Clinical microbial identification plays an important role in optimizing the management of infectious diseases and provides diagnostic and therapeutic support for clinical management. Microbial proteomic research is aimed at identifying proteins associated with microbial activity, which has facilitated the discovery of microbial physiology changes and host-pathogen interactions during bacterial infection and antimicrobial therapy. Here, we summarize proteomic-driven progresses of host-microbial pathogen interactions at multiple levels, mass spectrometry-based microbial proteome identification for clinical diagnosis, and antimicrobial therapy. Proteomic technique progresses pave new ways towards effective prevention and drug discovery for microbial-induced infectious diseases.
State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and National Collaborative Innovation Center for Biotherapy, No. 17, 3rd Section of People's South Road, Chengdu, 610041, People's Republic of China.
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Chen
State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and National Collaborative Innovation Center for Biotherapy, No. 17, 3rd Section of People's South Road, Chengdu, 610041, People's Republic of China.
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Zhang
State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and National Collaborative Innovation Center for Biotherapy, No. 17, 3rd Section of People's South Road, Chengdu, 610041, People's Republic of China.
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Wang
State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and National Collaborative Innovation Center for Biotherapy, No. 17, 3rd Section of People's South Road, Chengdu, 610041, People's Republic of China.
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Ma
Department of Urinary Surgery, West China Hospital, West China Medical School, Sichuan University, Chengdu, 610041, People's Republic of China.
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Deng
Department of Urinary Surgery, West China Hospital, West China Medical School, Sichuan University, Chengdu, 610041, People's Republic of China.
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Zhang
Laboratory of Cell and Molecular Biology & State Key Laboratory of Molecular Oncology, Cancer Institute & Cancer Hospital, Chinese Academy of Medical Sciences, Beijing, 100034, People's Republic of China.
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Zhu
State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and National Collaborative Innovation Center for Biotherapy, No. 17, 3rd Section of People's South Road, Chengdu, 610041, People's Republic of China.|Laboratory of Cell and Molecular Biology & State Key Laboratory of Molecular Oncology, Cancer Institute & Cancer Hospital, Chinese Academy of Medical Sciences, Beijing, 100034, People's Republic of China.
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Xu
State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and National Collaborative Innovation Center for Biotherapy, No. 17, 3rd Section of People's South Road, Chengdu, 610041, People's Republic of China. zizi2006@scu.edu.cn.
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Liang
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001419:Bacteria / Q000737:chemistry* / Q000145:classification / Q000302:isolation & purification / Q000472:pathogenicity; D001424:Bacterial Infections / Q000175:diagnosis* / Q000188:drug therapy*; D001431:Bacteriological Techniques / Q000379:methods; D003955:Diagnostic Tests, Routine / Q000379:methods; D054884:Host-Pathogen Interactions; D006801:Humans; D020543:Proteome / Q000032:analysis*; D040901:Proteomics / Q000379:methods* / Q000639:trends
D000900:Anti-Bacterial Agents; D020543:Proteome