DKK1 in relation to HCV induced liver cirrhosis and HCV induced HCC curative resection.
BACKGROUND
hepatitis C virus (HCV) is an RNA virus that induces hepatocarcinogenesis by mechanisms other than integration in the host cell genome. Dickkopf-1 (DKK1) expression has been studied mostly in hepatitis B virus induced HCC but not properly investigated in HCV induced HCC.


OBJECTIVE
Aim: we aimed to assess serum DKK1 in HCV induced HCC, HCV induced liver cirrhosis and viral infection-free controls. Moreover, we assessed serum DKK1 level after curative resection of HCC..


METHODS
Serum DKK1 was measured by ELISA in 20 HCV induced HCC patients; both pre-resection and post-resection, 20 HCV induced liver cirrhosis patients and 20 viral infection-free controls.


RESULTS
DKK1 levels were significantly higher in HCC than cirrhosis patients (P = 0.000). DKK1 did not differ significantly between cirrhotic patients and controls (P = 0.11). DKK1 levels significantly reduced 5 days post-resection compared to their pre-resection levels (P = 0.000).


CONCLUSIONS
We documented serum DKK1 as a marker for detection of early HCC in HCV infected patients. Significant reduction of DKK1 5 days after curative resection might indicated it as a follow up marker for recurrence in surgically resected HCV induced HCC patients. Larger scale studies to follow up its level at various intervals postoperatively and evaluate its pre-resection level as a prognostic marker in HCV induced HCC patients will be needed. (Acta gastro-enterol. belg., 2016, 79, 309-313).
E S
ES
Essa
B A
BA
Montaser
M T
MT
Badawy
A S
AS
Essa
M S
MS
Mokhtar
D000368:Aged; D015415:Biomarkers / Q000097:blood; D006528:Carcinoma, Hepatocellular / Q000097:blood / Q000209:etiology / Q000473:pathology / Q000601:surgery; D055088:Early Detection of Cancer / Q000379:methods; D005260:Female; D016174:Hepacivirus / Q000302:isolation & purification; D006498:Hepatectomy / Q000009:adverse effects / Q000379:methods; D019698:Hepatitis C, Chronic / Q000097:blood / Q000150:complications / Q000821:virology; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood*; D008103:Liver Cirrhosis / Q000097:blood / Q000175:diagnosis / Q000209:etiology / Q000821:virology; D008113:Liver Neoplasms / Q000097:blood / Q000209:etiology / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000097:blood / Q000175:diagnosis; D011184:Postoperative Period; D011446:Prospective Studies; D015203:Reproducibility of Results; D013223:Statistics as Topic
D015415:Biomarkers; C501126:DKK1 protein, human; D036341:Intercellular Signaling Peptides and Proteins