Structure and function of RNA elements present in enteroviral genomes.
Enteroviruses are small RNA(+) viruses that encode one open reading frame flanked by two extensive noncoding regions carrying structural RNA regulatory elements that control replication and translation processes. For a long time the central, coding region was thought to remain single-stranded and its only function was supposed to be as the template for polyprotein synthesis. It turned out, however, that the protein coding region also encodes important RNA structures crucial for the viral life cycle and virus persistence in the host cells. This review considers the RNA structures in enteroviral genomes identified and characterized to date.
Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznań, Poland.
Mariola
M
Dutkiewicz
Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznań, Poland.
Aleksandra
A
Stachowiak
Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznań, Poland.
Agata
A
Swiatkowska
Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznań, Poland.
Jerzy
J
Ciesiołka
D020413:3' Untranslated Regions; D001483:Base Sequence; D004770:Enterovirus / Q000235:genetics*; D040461:Gene Components; D016679:Genome, Viral; D006801:Humans; D055029:Inverted Repeat Sequences; D014176:Protein Biosynthesis; D012367:RNA, Viral / Q000235:genetics*; D014764:Viral Proteins / Q000235:genetics; D014779:Virus Replication
D020413:3' Untranslated Regions; D012367:RNA, Viral; D014764:Viral Proteins