Efficacy and Acceptability of Different Auxiliary Drugs in Pediatric Sevoflurane Anesthesia: A Network Meta-analysis of Mixed Treatment Comparisons.
Emergence agitation preventive medicine should be combined with pediatric anesthesia because of the high frequency of emergence agitation. However, it is challenging to determine the most appropriate medication that can be introduced into pediatric anesthesia for the sake of emergence agitation prevention. We reviewed and retrieved the data from PubMed and Embase. Various medications were assessed based on several endpoints including Emergence agitation outcomes (EA), postoperative nausea and vomiting (PONV), the number of patients who required analgesic (RA), pediatric anesthesia emergence delirium (PAED), the extubation time, the emergency time and the duration of post-anesthesia care unit (PACU) stay. Both traditional and network meta-analysis were carried in this study. A total of 45 articles were complied with the selection criteria and the corresponding articles were reviewed. Fentanyl demonstrated the highest cumulative ranking probability which was followed by those of ketamine and dexmedetomidine with respect to EA and PAED. When PONV and RA were concerned together, clonidine exhibited the highest cumulative ranking probability compared to other medications. Our study suggested that dexmedetomidine perhaps is the most appropriate prophylactic treatment which can be introduced into anesthesia for preventing emergence agitation.
Department of Anesthesiology, Pain Diagnosis and Treatment Center, Research Institute of Surgery &Daping Hospital, Third Military Medical University, Daping, Chongqing, 400042, China.
Wuchao
W
Wang
Department of Anesthesiology, Pain Diagnosis and Treatment Center, Research Institute of Surgery &Daping Hospital, Third Military Medical University, Daping, Chongqing, 400042, China.
Panchuan
P
Huang
Department of Anesthesiology, Pain Diagnosis and Treatment Center, Research Institute of Surgery &Daping Hospital, Third Military Medical University, Daping, Chongqing, 400042, China.
Weiwei
W
Gao
Department of Anesthesiology, Pain Diagnosis and Treatment Center, Research Institute of Surgery &Daping Hospital, Third Military Medical University, Daping, Chongqing, 400042, China.
Fangli
F
Cao
Department of Anesthesiology, Pain Diagnosis and Treatment Center, Research Institute of Surgery &Daping Hospital, Third Military Medical University, Daping, Chongqing, 400042, China.
Mingling
M
Yi
Department of Anesthesiology, Pain Diagnosis and Treatment Center, Research Institute of Surgery &Daping Hospital, Third Military Medical University, Daping, Chongqing, 400042, China.
Liyong
L
Chen
Department of Anesthesiology, Pain Diagnosis and Treatment Center, Research Institute of Surgery &Daping Hospital, Third Military Medical University, Daping, Chongqing, 400042, China.
Xiaoli
X
Guo
D000293:Adolescent; D000769:Anesthesia, Inhalation / Q000009:adverse effects / Q000379:methods*; D002648:Child; D002675:Child, Preschool; D020927:Dexmedetomidine / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008738:Methyl Ethers / Q000009:adverse effects / Q000627:therapeutic use*; D000077149:Sevoflurane
D008738:Methyl Ethers; D000077149:Sevoflurane; D020927:Dexmedetomidine