Cytokine pattern of the breast tumor supernatant.
Cytokine production was evaluated in supernatants of cultured tumor cells that were obtained by biopsy of the breast invasive ductal carcinoma (IDC) and breast fibroadenoma (FA) and grown in vitro. In the IDC supernatants, the concentrations of pro-inflammatory (pro-oncogenic) cytokines IL-17, IL-18, and IFNγ and of IL-1 receptor antagonist were significantly higher than in the FA cell supernatants. The concentrations of anti-inflammatory cytokine IL-10 and MCP-1 protein in supernatants of IDC cells were significantly lower than those determined in FA supernatants.
Novosibirsk State Medical University, Ministry of Health of the Russian Federation, Novosibirsk, Russia.|Research Institute of Molecular Biology and Biophysics, Novosibirsk, Russia.
A I
AI
Autenshlyus
Novosibirsk State Medical University, Ministry of Health of the Russian Federation, Novosibirsk, Russia. lpciip@211.ru.
T A
TA
Kunts
Research Institute of Molecular Biology and Biophysics, Novosibirsk, Russia.
K V
KV
Karpukhina
Novosibirsk State Medical University, Ministry of Health of the Russian Federation, Novosibirsk, Russia.|Research Institute of Molecular Biology and Biophysics, Novosibirsk, Russia.
E S
ES
Mikhaylova
ZAO Vector Best, Novosibirsk, Russia.
N A
NA
Varaksin
Novosibirsk State Medical University, Ministry of Health of the Russian Federation, Novosibirsk, Russia.
I O
IO
Marinkin
Research Institute of Molecular Biology and Biophysics, Novosibirsk, Russia.
V V
VV
Lyakhovich
D001943:Breast Neoplasms / Q000276:immunology*; D018270:Carcinoma, Ductal, Breast / Q000276:immunology*; D002458:Cell Fractionation; D016207:Cytokines / Q000276:immunology*; D005260:Female; D018226:Fibroadenoma / Q000276:immunology*; D006801:Humans; D018836:Inflammation Mediators / Q000276:immunology*; D014407:Tumor Cells, Cultured; D059016:Tumor Microenvironment / Q000276:immunology*
D016207:Cytokines; D018836:Inflammation Mediators