Synthetic Procedures Leading towards Aminobisphosphonates.
Growing interest in the biological activity of aminobisphosphonates has stimulated the development of methods for their synthesis. Although several general procedures were previously elaborated to reach this goal, aminobisphosphonate chemistry is still developing quite substantially. Thus, innovative modifications of the existing commonly used reactions, as well as development of new procedures, are presented in this review, concentrating on recent achievements. Additionally, selected examples of aminobisphosphonate derivatization illustrate their usefulness for obtaining new diagnostic and therapeutic agents.
Department of Bioorganic Chemistry, Faculty of Chemistry, Wrocław University of Science and Technology, Wrocław 50-370, Poland. ewa.chmielewska@pwr.edu.pl.
Ewa
E
Chmielewska
Department of Bioorganic Chemistry, Faculty of Chemistry, Wrocław University of Science and Technology, Wrocław 50-370, Poland. pawel.kafarski@pwr.edu.pl.
Paweł
P
Kafarski
D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry; D000981:Antiprotozoal Agents / Q000138:chemical synthesis / Q000737:chemistry; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry; D050071:Bone Density Conservation Agents / Q000138:chemical synthesis / Q000737:chemistry; D015394:Molecular Structure; D063065:Organophosphonates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
D000970:Antineoplastic Agents; D000981:Antiprotozoal Agents; D000998:Antiviral Agents; D050071:Bone Density Conservation Agents; D063065:Organophosphonates
Vilsmayer-Haack-like reactions; bisphosphonates; bisphosphonylation procedures; functionalization of aminoalkylbisphosphonates