Base-Promoted Intermolecular Cyclization of Substituted 3-Aryl(Heteroaryl)-3-chloroacrylaldehydes and Tetrahydroisoquinolines: An Approach to Access Pyrrolo[2,1-a]isoquinolines.
We have developed a new base-promoted intermolecular cascade cyclization reaction of substituted 3-aryl(heteroaryl)-3-chloroacrylaldehydes and tetrahydroisoquinolines in one pot. The reaction provides a facile and practical synthesis of pyrrolo[2,1-a]isoquinolines. A number of pyrrolo[2,1-a]isoquinolines were synthesized in moderate to high yields (up to 97%).
Department of Organic Chemistry, College of Chemistry, Jilin University , Changchun 130012, P. R. China.
Ziqi
Z
Yang
Department of Organic Chemistry, College of Chemistry, Jilin University , Changchun 130012, P. R. China.
Ning
N
Lu
Department of Organic Chemistry, College of Chemistry, Jilin University , Changchun 130012, P. R. China.
Zhonglin
Z
Wei
Department of Organic Chemistry, College of Chemistry, Jilin University , Changchun 130012, P. R. China.
Jungang
J
Cao
Department of Organic Chemistry, College of Chemistry, Jilin University , Changchun 130012, P. R. China.
Dapeng
D
Liang
Department of Organic Chemistry, College of Chemistry, Jilin University , Changchun 130012, P. R. China.
Haifeng
H
Duan
Department of Organic Chemistry, College of Chemistry, Jilin University , Changchun 130012, P. R. China.
Yingjie
Y
Lin