Signaling in Sperm: More Different than Similar.
For a given sensory cell type, signaling motifs are rather uniform across phyla. By contrast, sperm from different species use diverse repertoires of sperm-specific signaling molecules and even closely related protein isoforms feature different properties and serve different functions. This surprising diversity has consequences for strategies in fertilization research and it will take some time to get the big picture. We discuss the function of receptors, ion channels, and exchangers embedded in cellular pathways from different sperm species.
Center of Advanced European Studies and Research (CAESAR), Department of Molecular Sensory Systems, Ludwig-Erhard-Allee 2, 53175 Bonn, Germany. Electronic address: u.b.kaupp@caesar.de.
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Kaupp
University Hospital Münster, Center of Reproductive Medicine and Andrology, Albert-Schweitzer-Campus 1, Geb. D11, 48149 Münster, Germany.
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Strünker
D000818:Animals; D005306:Fertilization; D006801:Humans; D007473:Ion Channels / Q000378:metabolism; D008297:Male; D008322:Mammals / Q000378:metabolism; D008954:Models, Biological; D015398:Signal Transduction; D013094:Spermatozoa / Q000378:metabolism*
D007473:Ion Channels
calcium; cyclic nucleotides; ion channels; microswimmer; protons