Pilot Study of an Exercise Intervention for Depressive Symptoms and Associated Cognitive-Behavioral Factors in Young Adults With Major Depression.
This study assesses the feasibility of integrating motivational interviewing (MI) with an exercise intervention. It also explores patterns of depressive symptom changes (cognitive, affective, and somatic subscales) and their relationship to cognitive, behavioral, and immunological factors (interleukin 6, IL-6, a marker for inflammation) across the exercise intervention. Twelve young adults (20.8 ± 1.7 years) meeting DSM-IV criteria for major depressive disorder received a brief MI intervention followed by a 12-week exercise intervention. Assessments were conducted preintervention, postintervention, throughout the intervention, and at follow-up. Preliminary results show differential effects of exercise, with the largest standardized mean improvements for the affective subscale (-1.71), followed by cognitive (-1.56) and somatic (-1.39) subscales. A significant relationship was observed between increased behavioral activation and lower levels of IL-6. Despite study limitations, the magnitude of changes suggests that natural remission of depressive symptoms is an unlikely explanation for the findings. A randomized controlled trial has commenced to evaluate effectiveness of the intervention.
*School of Psychology, and †Priority Research Centre for Brain and Mental Health Research, School of Medicine and Public Health, Faculty of Health, University of Newcastle, Callaghan, New South Wales; ‡School of Psychology & Counselling, Institute of Health & Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Queensland; and §Priority Research Centre for Physical Activity and Nutrition, University of Newcastle, Callaghan, New South Wales, Australia.
Yasmina
Y
Nasstasia
Amanda L
AL
Baker
Sean A
SA
Halpin
Terry J
TJ
Lewin
Leanne
L
Hides
Brian J
BJ
Kelly
Robin
R
Callister
D000293:Adolescent; D000328:Adult; D003131:Combined Modality Therapy; D003865:Major Depressive Disorder / Q000097:blood / Q000503:physiopathology / Q000628:therapy*; D005081:Exercise Therapy / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D062405:Motivational Interviewing / Q000379:methods*; D017063:Outcome Assessment, Health Care; D010865:Pilot Projects; D055815:Young Adult
C508600:IL6 protein, human; D015850:Interleukin-6