Voluntary control of intracortical oscillations for reconfiguration of network activity.
Voluntary control of oscillatory activity represents a key target in the self-regulation of brain function. Using a real-time closed-loop paradigm and simultaneous macro- and micro-electrode recordings, we studied the effects of self-induced intracortical oscillatory activity (4-8 Hz) in seven neurosurgical patients. Subjects learned to robustly and specifically induce oscillations in the target frequency, confirmed by increased oscillatory event density. We have found that the session-to-session variability in performance was explained by the functional long-range decoupling of the target area suggesting a training-induced network reorganization. Downstream effects on more local activities included progressive cross-frequency-coupling with gamma oscillations (30-120 Hz), and the dynamic modulation of neuronal firing rates and spike timing, indicating an improved temporal coordination of local circuits. These findings suggest that effects of voluntary control of intracortical oscillations can be exploited to specifically target plasticity processes to reconfigure network activity, with a particular relevance for memory function or skill acquisition.
Institut du Cerveau et de la Moelle Epinière, INSERM UMR S 1127, CNRS UMR 7225, Hôpital de la Pitié-Salpêtrière, Paris France.|Sorbonne University, UPMC-Paris 6, F-75005, Paris, France.
Juliana
J
Corlier
Department of Biomedical Engineering, Universidad de Los Andes, Bogotá D.C., Colombia.
Mario
M
Valderrama
Department of Biomedical Engineering, Universidad de Los Andes, Bogotá D.C., Colombia.
Miguel
M
Navarrete
Institut du Cerveau et de la Moelle Epinière, INSERM UMR S 1127, CNRS UMR 7225, Hôpital de la Pitié-Salpêtrière, Paris France.|Centre de NeuroImagerie de Recherche-CENIR, Institut du Cerveau et de la Moelle Epinière, UPMC-Paris 6, INSERM UMR S 1127 CNRS 7225, Hôpital Pitié-Salpêtrière, Paris, France.
Katia
K
Lehongre
Institut du Cerveau et de la Moelle Epinière, INSERM UMR S 1127, CNRS UMR 7225, Hôpital de la Pitié-Salpêtrière, Paris France.|Sorbonne University, UPMC-Paris 6, F-75005, Paris, France.|AP-HP, GH Pitié-Salpêtrière, Epilepsy Unit, F-75013, Paris, France.
Dominique
D
Hasboun
Institut du Cerveau et de la Moelle Epinière, INSERM UMR S 1127, CNRS UMR 7225, Hôpital de la Pitié-Salpêtrière, Paris France.|Sorbonne University, UPMC-Paris 6, F-75005, Paris, France.|AP-HP, GH Pitié-Salpêtrière, Epilepsy Unit, F-75013, Paris, France.
Claude
C
Adam
Institut du Cerveau et de la Moelle Epinière, INSERM UMR S 1127, CNRS UMR 7225, Hôpital de la Pitié-Salpêtrière, Paris France.|Sorbonne University, UPMC-Paris 6, F-75005, Paris, France.|AP-HP, GH Pitié-Salpêtrière, Neurosurgery Department, F-75013, Paris, France.
Hayat
H
Belaid
Institut du Cerveau et de la Moelle Epinière, INSERM UMR S 1127, CNRS UMR 7225, Hôpital de la Pitié-Salpêtrière, Paris France.|Sorbonne University, UPMC-Paris 6, F-75005, Paris, France.|AP-HP, GH Pitié-Salpêtrière, Neurosurgery Department, F-75013, Paris, France.
Stéphane
S
Clémenceau
Institut du Cerveau et de la Moelle Epinière, INSERM UMR S 1127, CNRS UMR 7225, Hôpital de la Pitié-Salpêtrière, Paris France.|Sorbonne University, UPMC-Paris 6, F-75005, Paris, France.|AP-HP, GH Pitié-Salpêtrière, Epilepsy Unit, F-75013, Paris, France.
Michel
M
Baulac
Institut du Cerveau et de la Moelle Epinière, INSERM UMR S 1127, CNRS UMR 7225, Hôpital de la Pitié-Salpêtrière, Paris France.|Sorbonne University, UPMC-Paris 6, F-75005, Paris, France.
Stéphane
S
Charpier
Institut du Cerveau et de la Moelle Epinière, INSERM UMR S 1127, CNRS UMR 7225, Hôpital de la Pitié-Salpêtrière, Paris France.|Sorbonne University, UPMC-Paris 6, F-75005, Paris, France.|AP-HP, GH Pitié-Salpêtrière, Epilepsy Unit, F-75013, Paris, France.
Vincent
V
Navarro
Institut du Cerveau et de la Moelle Epinière, INSERM UMR S 1127, CNRS UMR 7225, Hôpital de la Pitié-Salpêtrière, Paris France.|Sorbonne University, UPMC-Paris 6, F-75005, Paris, France.
Michel
M
Le Van Quyen
D000200:Action Potentials / Q000502:physiology; D000328:Adult; D058256:Brain Waves / Q000502:physiology; D002540:Cerebral Cortex / Q000166:cytology / Q000502:physiology*; D004569:Electroencephalography / Q000379:methods; D004827:Epilepsy / Q000503:physiopathology; D005260:Female; D006801:Humans; D007858:Learning / Q000502:physiology; D008297:Male; D008875:Middle Aged; D008959:Models, Neurological; D009415:Nerve Net / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D055815:Young Adult