Effect of vitamin D supplementation on health status in non-vitamin D deficient people with type 2 diabetes mellitus.
OBJECTIVE
Increased levels of depressive symptoms, fatigue or pain (all dimensions of reduced health-related quality of life (HRQOL)) are common in people with type 2 diabetes mellitus (DM). Earlier studies have reported associations between low vitamin D status and fatigue and depressive symptoms. The aim of the present study was to examine the effects of vitamin D supplementation on dimensions of HRQOL in people with type 2 DM.


METHODS
Randomised, double-blind, placebo-controlled trial.


METHODS
The effect of monthly cholecalciferol 50,000 IU vs placebo on HRQOL was assessed in 275 adults with type 2 DM derived from general practices. HRQOL at baseline and after six months using the Short Form 36 Health Survey (SF-36) was collected. Linear regression analyses were used to compare the change in HRQOL over time between the vitamin D and placebo group.


RESULTS
187/275 (68%) completed baseline and follow-up SF-36 and were included in the analysis. Median serum 25-hydroxyvitamin D almost doubled in the intervention group compared to that in the placebo group (58.5-106.0 nmol/L vs 60.0-61.5 nmol/L, respectively). A small significant difference (adjusted B: -8.90; 95% CI: -17.16 to -0.65) between both groups was seen concerning the SF-36 domain role limitations due to physical problems in disadvantage of the vitamin D group.


CONCLUSIONS
Six months of vitamin D supplementation did not improve HRQOL in non-vitamin D-deficient people with type 2 DM managed on oral antidiabetic therapy.
Department of Internal MedicineMedical Centre Alkmaar, Alkmaar, the Netherlands.
S
S
Westra
Department of Internal MedicineMedical Centre Alkmaar, Alkmaar, the Netherlands.
Y H M
YH
Krul-Poel
Department of General PracticeDIAZON, Alkmaar, the Netherlands.
H J
HJ
van Wijland
Department of Epidemiology and BiostatisticsVU Medical Centre, Amsterdam, the Netherlands.
M M
MM
Ter Wee
Department of Internal MedicineMedical Centre Alkmaar, Alkmaar, the Netherlands.
F
F
Stam
Department of Internal MedicineEndocrine Section, VU Medical Centre, Amsterdam, the Netherlands.
P
P
Lips
Department of Medical and Clinical PsychologyTilburg University, Tilburg, the Netherlands.
F
F
Pouwer
Department of Internal MedicineMedical Centre Alkmaar, Alkmaar, the Netherlands s.simsek@mca.nl.
S
S
Simsek
RCT; health-related quality of life; type 2 diabetes mellitus; vitamin D