Successful engraftment after hematopoietic stem cell transplantation with infusion of donor stem cells through the extracorporeal membrane oxygenation circuit.
Wiskott-Aldrich syndrome (WAS) is a rare X-linked primary immunodeficiency due to mutations in the WAS gene expressed in hematopoietic cells. Hematopoietic stem cell transplantation (HSCT) is the treatment of choice when an appropriate human leukocyte antigen-matched donor is available. The use of the extracorporeal membrane oxygenation (ECMO) circuit to infuse donor cells for HSCT has not been previously published in the literature. We describe a case of a child who had successful engraftment after HSCT with infusion of the donor stem cells through the ECMO circuit.
Department of Pediatrics, Division of Critical Care Medicine, University of Texas Southwestern/Children's Health Dallas, TX, USA.
Pilar
P
Anton-Martin
Department of Pediatrics, Division of Critical Care Medicine, University of Texas Southwestern/Children's Health Dallas, TX, USA.
Cindy
C
Darnell-Bowens
Department of Pediatrics, Division of Hematology-Oncology, University of Texas Southwestern/Children's Health Dallas, TX, USA.
Victor M
VM
Aquino
Department of Pediatrics, Division of Hematology-Oncology, University of Texas Southwestern/Children's Health Dallas, TX, USA.
Teresa
T
Jones
Department of Pediatrics, Division of Critical Care Medicine, University of Texas Southwestern/Children's Health Dallas, TX, USA.
Lakshmi
L
Raman
Engraftment; Wiskott–Aldrich syndrome; extracorporeal membrane oxygenation; hematopoietic stem cell transplantation