[Association between interleukin-1β C+3953T and genetic susceptibility to spontaneous preterm birth: a case-control study].
OBJECTIVE
To study the association between interleukin-1β (IL-1β) C+3953T and genetic susceptibility to spontaneous preterm birth (SPTB).


METHODS
In this case-control study, 753 SPTB neonates were enrolled in the case group and 681 full-term neonates were enrolled in the control group. The latest Sequenom MassARRAY®SNP detection technique was used for the typing of single nucleotide polymorphisms (SNP) of IL-1β C+3953T.


RESULTS
Compared with those carrying CC genotype of IL-1β C+3953T, the neonates who carried at least one T allele (CT+TT genotype) had significantly increased risks of SPTB, SPTB complicated by premature rupture of membranes, and mild preterm birth.


CONCLUSIONS
In the Chinese population, IL-1β C+3953T has significant genetic association with an increased risk of SPTB. The identification of this SNP helps to prevent SPTB and clarify the causes and pathogenesis of SPTB.
Developmental Biology Laboratory, Baiyi Children's Hospital Affiliated to Chinese People's Liberation Army General Hospital, Beijing 100700, China. 001wangyan@sina.com.
Xiao
X
Yang
Wei
W
Peng
Li-Na
LN
Zhu
Xiao-Ai
XA
Zhang
Yan
Y
Wang
D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007231:Infant, Newborn; D053583:Interleukin-1beta / Q000235:genetics*; D008297:Male; D020641:Polymorphism, Single Nucleotide; D047928:Premature Birth / Q000209:etiology / Q000235:genetics*
D053583:Interleukin-1beta