VEGF +936 C/T Genetic Polymorphism in Patients with Cervical Dysplasia.
Aim. The present study aims to analyze the potential role of VEGF +936 C/T polymorphism in cervical intraepithelial neoplasia.Material and Method. One hundred and eighty-six patients were included in the study: 75 cases (patients diagnosed with CIN) and 111 controls (negative for both HPV testing and cytology). For each patient a single visit was scheduled when colposcopy was performed. From cervical specimen, cytology and HPV testing were performed and from peripheral blood VEGF +936 genotyping was determined. For statistical analysis purposes OR and chi-square were used at a level of significance of <0.05.Results. No link has been found in the detection of CT genotype in cases versus controls, OR = 0.8295, [0.42, 1.62]. An inverse correlation has been found between T allele and HSIL, OR = 0.2121, [0.0473, 0.9517],p= 0.0866.Conclusion. No link has been found between VEGF +936 C/T and cervical intraepithelial neoplasia.
1st Clinic of Obstetrics and Gynecology, University of Medicine and Pharmacy "Iuliu Hatieganu", Clinicilor 3-5, 400006 Cluj-Napoca, Romania.
Ioana Cristina
0000-0002-7700-2384
IC
Rotar
Department of Economic Sciences, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, Calea Manastur 3-5, 400372 Cluj-Napoca, Romania.
Diana Elena
DE
Dumitras
Department of Molecular Sciences, University of Medicine and Pharmacy "Iuliu Hatieganu", Clinicilor 3-5, 400006 Cluj-Napoca, Romania.
Radu Anghel
RA
Popp
Department of Molecular Sciences, University of Medicine and Pharmacy "Iuliu Hatieganu", Clinicilor 3-5, 400006 Cluj-Napoca, Romania.
Felicia Maria
FM
Petrisor
1st Clinic of Obstetrics and Gynecology, Emergency County Hospital, Cluj-Napoca, Romania.
Paul
P
Cotutiu
1st Clinic of Obstetrics and Gynecology, University of Medicine and Pharmacy "Iuliu Hatieganu", Clinicilor 3-5, 400006 Cluj-Napoca, Romania.
Florin
F
Stamatian
1st Clinic of Obstetrics and Gynecology, University of Medicine and Pharmacy "Iuliu Hatieganu", Clinicilor 3-5, 400006 Cluj-Napoca, Romania.
Daniel
0000-0002-7744-0501
D
Muresan
D000328:Adult; D000483:Alleles; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D002583:Uterine Cervical Neoplasms / Q000235:genetics*; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics*; D002578:Uterine Cervical Dysplasia / Q000235:genetics*
D042461:Vascular Endothelial Growth Factor A