Evaluation of antinociceptive and antirheumatic activity ofGrangea maderaspatana(L.) Poir. using experimental models.
BACKGROUND
Grangea maderaspatana(L.) Poir. (Asteraceae), a popular Indian medicinal plant is traditionally used for rheumatism in the knee joint and pain in the muscles.


OBJECTIVE
To investigate antinociceptive and antirheumatic activity ofG. maderaspatana(L.) Poir. using experimental models.


METHODS
Antinociceptive activity of methanolic extract ofG. maderaspatana(L.) Poir. (GMME) (500 mg/kg, 1000 mg/kg, p.o.) was evaluated in rats using tail flick test. Anti-inflammatory and anti-arthritic activity of GMME (1000 mg/kg, p.o.) was evaluated using carrageenan-induced rat paw edema and complete Freund's adjuvant (CFA)- induced arthritis models. The degree of arthritis was evaluated by hind paw swelling, body weight changes, arthritic index, erythrocyte sedimentation rate (ESR), rheumatoid factor (RF), and C-reactive protein (CRP) supported by histopathology of ankle joints.


RESULTS
GMME treatment showed a significant increase in the latency for tail flick and provided significant protection against carrageenan-induced rat paw edema. 21 days treatment of GMME significantly inhibited paw edema found to be induced by arthritis by CFA in rats. Further, GMME treatment also reversed arthritic index and loss of body weight and reduced CFA-induced rise of ESR, RF, and CRP significantly in rats. Histopathological study of ankle joint revealed that GMME inhibited edema formation and cellular infiltration induced by CFA.


CONCLUSIONS
GMME possesses antinociceptive, anti-inflammatory, and antirheumatic activities.
Department of Pharmacology, A.R. College of Pharmacy and G.H. Patel Institute of Pharmacy, Vallabh Vidyanagar, Gujarat, India.
Raxit P
RP
Rachchh
Department of Pharmacology, A.R. College of Pharmacy and G.H. Patel Institute of Pharmacy, Vallabh Vidyanagar, Gujarat, India.
Varsha J
VJ
Galani
Antinociceptive; Freund's adjuvant; Grangea maderasptana; antirheumatic; carrageenan