Effect of polypeptides from sea anemone Heteractis crispa on the rodent blood pressure, heart rate, and hemostasis.
АРНС1-3 peptides, modulators of TRPV1 receptors, have been administered to SD rats to study their influence on the animal hemostatic system, heart rate, and blood pressure. None of АЗРС1-3 polypeptides have any effect on the hemostatic system. Both АРНС1 and АРНС2 polypeptides increased significantly the heart rate, but they did not affect blood pressure, which was probably caused by an ability of these polypeptides to modify animal thermoregulation.
Pushchino Branch, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Pushchino, Moscow oblast, Russia.|Pushchino State Institute of Natural Sciences, Pushchino, Moscow oblast, Russia.
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Skobtsova
Pushchino Branch, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Pushchino, Moscow oblast, Russia. dyachenko@bibch.ru.|Pushchino State Institute of Natural Sciences, Pushchino, Moscow oblast, Russia. dyachenko@bibch.ru.
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Dyachenko
Shemyakm-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
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Andreev
Shemyakm-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
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Logashina
Pushchino Branch, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Pushchino, Moscow oblast, Russia.|Pushchino State Institute of Natural Sciences, Pushchino, Moscow oblast, Russia.
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Murashev
Shemyakm-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
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Grishin
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects / Q000502:physiology*; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology*; D006487:Hemostasis / Q000187:drug effects / Q000502:physiology*; D008297:Male; D010455:Peptides / Q000008:administration & dosage* / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D012615:Sea Anemones / Q000737:chemistry* / Q000145:classification; D016896:Treatment Outcome
D010455:Peptides