AMPK in Neurodegenerative Diseases.
Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis are neurodegenerative disorders that are characterized by a progressive degeneration of nerve cells eventually leading to dementia. While these diseases affect different neuronal populations and present distinct clinical features, they share in common several features and signaling pathways. In particular, energy metabolism defects, oxidative stress, and excitotoxicity are commonly described and might be correlated with AMP-activated protein kinase (AMPK) deregulation. AMPK is a master energy sensor which was reported to be overactivated in the brain of patients affected by these neurodegenerative disorders. While the exact role played by AMPK in these diseases remains to be clearly established, several studies reported the implication of AMPK in various signaling pathways that are involved in these diseases' progression. In this chapter, we review the current literature regarding the involvement of AMPK in the development of these diseases and discuss the common pathways involved.
Univ. Lille, Inserm, CHU Lille, UMR-S 1172 - JPArc - Centre de Recherche Jean-Pierre AUBERT, F-59000, Lille, France.
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Domise
Univ. Lille, Inserm, CHU Lille, UMR-S 1172 - JPArc - Centre de Recherche Jean-Pierre AUBERT, F-59000, Lille, France. valerie.vingtdeux@inserm.fr.
Valérie
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Vingtdeux
D055372:AMP-Activated Protein Kinases / Q000235:genetics* / Q000378:metabolism; D000544:Alzheimer Disease / Q000201:enzymology* / Q000235:genetics / Q000473:pathology; D000690:Amyotrophic Lateral Sclerosis / Q000201:enzymology* / Q000235:genetics / Q000473:pathology; D001921:Brain / Q000201:enzymology / Q000473:pathology; D003704:Dementia / Q000201:enzymology* / Q000235:genetics / Q000473:pathology; D004734:Energy Metabolism / Q000235:genetics; D005786:Gene Expression Regulation; D006801:Humans; D006816:Huntington Disease / Q000201:enzymology* / Q000235:genetics / Q000473:pathology; D009474:Neurons / Q000201:enzymology / Q000473:pathology; D018384:Oxidative Stress; D010300:Parkinson Disease / Q000201:enzymology* / Q000235:genetics / Q000473:pathology; D021122:Protein Subunits / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction
D021122:Protein Subunits; D055372:AMP-Activated Protein Kinases
AMPK; Alzheimer’s disease; Amyotrophic lateral sclerosis; Huntington’s disease; Neurodegeneration; Parkinson’s disease