A Radium-223 microgenerator from cyclotron-produced trace Actinium-227.
The alpha particle emitter Radium-223 dichloride (223RaCl2) has recently been approved for treatment of late-stage bone metastatic prostate cancer. There is considerable interest in studying this new agent outside of the clinical setting, however the supply of223Ra is limited and expensive. We have engineered a223Ra microgenerator using traces of227Ac previously generated from cyclotron-produced225Ac. Radiochemically pure223RaCl2was made, characterized, evaluated in vivo, and the source was recovered in high yield for regeneration of the microgenerator.
Division of Nuclear Medicine and Molecular Imaging, Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Diane S
DS
Abou
Division of Nuclear Medicine and Molecular Imaging, Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Juile
J
Pickett
Johns Hopkins University Applied Physics Laboratory, 11100 Johns Hopkins Road, Laurel, MD 20723-6099, USA.
John E
JE
Mattson
Division of Nuclear Medicine and Molecular Imaging, Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Cancer Molecular and Functional Imaging Program, Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address: thorek.laboratory@jhmi.edu.
Daniel L J
DLJ
Thorek
(223)Ra; (227)Ac; (227)Th; Microgenerator; Purification