Complete remission of liver metastasis in a lung cancer patient with epidermal growth factor mutation achieved with Icotinib.
A 65-year-old Chinese male was referred to our hospital for epidermal growth factor receptor (EGFR)-mutated advanced non-small cell lung cancer (NSCLC). Aggressive combined therapy with surgical resection of the right upper lung lesion and chemotherapy was performed. One month later, continued Icotinib treatment was used as magnetic resonance imaging revealed liver metastasis (LM). Interestingly, complete remission of the patient's LM lesions was achieved in six months. To our knowledge, this is the first report documenting a successful case of an NSCLC patient with LM treated with Icotinib after receiving a radical resection for pulmonary carcinoma. Our experience could provide a treatment strategy for patients with similar disease.
Department of Thoracic Surgery, The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Zhouyu
Z
Zhu
Department of Thoracic Surgery, The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China. chai_y@126.com.
Ying
Y
Chai
D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics / Q000628:therapy*; D043844:Crown Ethers / Q000008:administration & dosage* / Q000627:therapeutic use; D066246:ErbB Receptors / Q000235:genetics*; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics / Q000628:therapy*; D008297:Male; D009154:Mutation; D013510:Pulmonary Surgical Procedures; D011799:Quinazolines / Q000008:administration & dosage* / Q000627:therapeutic use; D012074:Remission Induction; D016896:Treatment Outcome
D043844:Crown Ethers; D011799:Quinazolines; C531470:icotinib; C512478:EGFR protein, human; D066246:ErbB Receptors

Adenocarcinoma; 
EGFR
; 
Icotinib; 
TKI
; liver metastasis