Mitochondrial Quality Control in Cardiac Diseases.
Disruption of mitochondrial homeostasis is a hallmark of cardiac diseases. Therefore, maintenance of mitochondrial integrity through different surveillance mechanisms is critical for cardiomyocyte survival. In this review, we discuss the most recent findings on the central role of mitochondrial quality control processes including regulation of mitochondrial redox balance, aldehyde metabolism, proteostasis, dynamics, and clearance in cardiac diseases, highlighting their potential as therapeutic targets.
Department of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo Sao Paulo, Brazil.
Juliane C
JC
Campos
Department of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo Sao Paulo, Brazil.
Luiz H M
LH
Bozi
Department of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo Sao Paulo, Brazil.
Luiz R G
LR
Bechara
Department of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo Sao Paulo, Brazil.
Vanessa M
VM
Lima
Department of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo Sao Paulo, Brazil.
Julio C B
JC
Ferreira
4-hydroxynonenal; aldehyde dehydrogenase 2; bioenergetics; fusion-fission balance; mitochondrial unfolded protein response; mitophagy; oxidative stress