[Clinical effect of high-frequency oscillatory ventilation combined with pulmonary surfactant in treatment of neonatal severe meconium aspiration syndrome complicated by pulmonary hemorrhage].
OBJECTIVE
To study the clinical effect and safety of high-frequency oscillatory ventilation (HFOV) combined with pulmonary surfactant (PS) in the treatment of neonatal severe meconium aspiration syndrome (MAS) complicated by neonatal pulmonary hemorrhage (NPH).


METHODS
A total of 48 children with severe MAS complicated by NPH were enrolled, and a retrospective analysis was performed for the clinical effects of HFOV+PS (trial group, 25 children) and HFOV alone (control group, 23 children). The blood gas parameters, oxygenation index (OI), PaO2/FiO2(P/F) value, duration of pulmonary hemorrhage, ventilation time, length of hospital stay, incidence of complications, and outcome were compared between the two groups.


RESULTS
At 6, 12, 24, and 48 hours after treatment, the trial group had significantly better PaO2, OI, and P/F value than the control group (P<0.05). Compared with the control group, the trial group had significantly shortened ventilation time and duration of pulmonary hemorrhage (P<0.05). There were no significant differences in the length of hospital stay, the incidence of complications, and cure rate between the two groups (P>0.05).


CONCLUSIONS
HFOV combined with PS can better improve oxygenation function and shorten the duration of NPH and ventilation time. Meanwhile, it does not increase the incidence of adverse events. Therefore, it is a safe and effective therapy.
Department of Neonatology, Maternal and Child Health Care Hospital of Xiamen, Xiamen, Fujian 361000, China. xinzhufj@163.com.
Jing
J
Huang
Xin-Zhu
XZ
Lin
Zhi
Z
Zheng
D003131:Combined Modality Therapy; D005260:Female; D006470:Hemorrhage / Q000628:therapy*; D006612:High-Frequency Ventilation; D006801:Humans; D007231:Infant, Newborn; D008171:Lung Diseases / Q000628:therapy*; D008297:Male; D008471:Meconium Aspiration Syndrome / Q000150:complications / Q000188:drug therapy*; D011663:Pulmonary Surfactants / Q000627:therapeutic use*
D011663:Pulmonary Surfactants