Phytosomes as Biocompatible Carriers of Natural Drugs.
Natural products have been frequently used as sources of clinical useful pharmaceuticals. However, some intrinsic characteristics of the natural drugs have limited their use, namely their solubility and chemical stability in physiologic mediums. Innovative drug delivery systems may help overcome such limitations, thus providing more effective administration of natural products. Phytosome (Indena SPA, Italy) is one of the most exciting recent delivery technologies that improves the oral bioavailability of the phytopharmaceuticals by their inclusion in equimolar complexes with dietary phospholipids with vesicular shape in aqueous environments. The purpose of this review is to characterize the state of the art of the phytosome as drug delivery system of natural products, including a discussion of the natural drug-phospholipid complex interactions, mechanisms of oral and topical delivery, methods of preparation and phytosome recent applications and patents in the 2006-2016 period.
CBiOS, Research Center for Biosciences & Health Technologies, Universidade Lusófona, Campo Grande 376, 1749-024 Lisboa, Portugal.
Diogo
D
Matias
CBiOS, Research Center for Biosciences & Health Technologies, Universidade Lusófona, Campo Grande 376, 1749-024 Lisboa, Portugal.
Patrícia
P
Rijo
Escola de Ciências e Tecnologias da Saúde, Universidade Lusófona, Campo Grande, 376, 1749-024 Lisboa, Portugal.
Catarina Pinto
CP
Reis
D000818:Animals; D001672:Biocompatible Materials / Q000008:administration & dosage*; D001688:Biological Products / Q000008:administration & dosage* / Q000494:pharmacology*; D016503:Drug Delivery Systems; D006801:Humans
D001672:Biocompatible Materials; D001688:Biological Products
Phytosome; clinical and nutritional uses; innovative drug delivery systems; natural compounds; phyto-phospholipidic complex; preparation and characterization techniques