Modeling Intracochlear Magnetic Stimulation: A Finite-Element Analysis.
This study models induced electric fields, and their gradient, produced by pulsatile current stimulation of submillimeter inductors for cochlear implantation. Using finite-element analysis, the lower chamber of the cochlea, scala tympani, is modeled as a cylindrical structure filled with perilymph bounded by tissue, bone, and cochlear neural elements. Single inductors as well as an array of inductors are modeled. The coil strength (~100 nH) and excitation parameters (peak current of 1-5 A, voltages of 16-20 V) are based on a formative feasibility study conducted by our group. In that study, intracochlear micromagnetic stimulation achieved auditory activation as measured through the auditory brainstem response in a feline model. With respect to the finite element simulations, axial symmetry of the inductor geometry is exploited to improve computation time. It is verified that the inductor coil orientation greatly affects the strength of the induced electric field and thereby the ability to affect the transmembrane potential of nearby neural elements. Furthermore, upon comparing an array of micro-inductors with a typical multi-site electrode array, magnetically excited arrays retain greater focus in terms of the gradient of induced electric fields. Once combined with further in vivo analysis, this modeling study may enable further exploration of the mechanism of magnetically induced, and focused neural stimulation.
S
S
Mukesh
D T
DT
Blake
B J
BJ
McKinnon
P T
PT
Bhatti
D003051:Cochlea / Q000502:physiology* / Q000528:radiation effects*; D003198:Computer Simulation; D004307:Dose-Response Relationship, Radiation; D004599:Electric Stimulation Therapy / Q000379:methods*; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology* / Q000528:radiation effects*; D020342:Finite Element Analysis; D006801:Humans; D055909:Magnetic Field Therapy / Q000379:methods; D060526:Magnetic Fields; D008954:Models, Biological; D011829:Radiation Dosage