Synthesis and Molecular Structure of99Tc Corroles.
The first99Tc corroles have been synthesized and fully characterized. A single-crystal X-ray structure of a99TcO triarylcorrole revealed nearly identical geometry parameters as the corresponding ReO structure. A significant spectral shift between the Soret maxima of TcO (410-413 nm) and ReO (438-441 nm) corroles was observed and, based on two-component spin-orbit ZORA TDDFT calculations, ascribed to relativistic effects in the Re case. The syntheses reported herein potentially pave the way toward99mTc-porphyrinoid-based radiopharmaceuticals.
Department of Chemistry, UiT-The Arctic University of Norway, 9037, Tromsø, Norway.
Rune F
RF
Einrem
Department of Chemistry, University of Zurich, Winterthurerstrasse 190, 8057, Zürich, Switzerland.
Henrik
H
Braband
Department of Chemistry, University of Zurich, Winterthurerstrasse 190, 8057, Zürich, Switzerland.
Thomas
T
Fox
Department of Chemistry, UiT-The Arctic University of Norway, 9037, Tromsø, Norway.
Hugo
H
Vazquez-Lima
Department of Chemistry, University of Zurich, Winterthurerstrasse 190, 8057, Zürich, Switzerland.
Roger
R
Alberto
Department of Chemistry, UiT-The Arctic University of Norway, 9037, Tromsø, Norway.
Abhik
http://orcid.org/0000-0003-1161-6364
A
Ghosh
corroles; imaging; radiopharmaceuticals; technetium; theranostics