Multicomponent 1,3-Bifunctionalization of Donor-Acceptor Cyclopropanes with Arenes and Nitrosoarenes.
AlBr3-mediated multicomponent 1,3-bifunctionalization of donor-acceptor cyclopropanes using arenes and nitrosoarenes as coupling partners is presented. In the cascade, a C-C, a C-N, and a C-Br bond is formed. Reactions are easy to conduct and proceed under mild conditions. The γ,γ-disubstituted N-arylated α-amino esters obtained as products are readily further chemically modified rendering the method valuable.
NRW Graduate School of Chemistry and ‡Organisch-Chemisches Institut, Westfalische Wilhelms-Universität , Corrensstraβe 40, 48149 Münster, Germany.
Saikat
S
Das
NRW Graduate School of Chemistry and ‡Organisch-Chemisches Institut, Westfalische Wilhelms-Universität , Corrensstraβe 40, 48149 Münster, Germany.
Constantin G
CG
Daniliuc
NRW Graduate School of Chemistry and ‡Organisch-Chemisches Institut, Westfalische Wilhelms-Universität , Corrensstraβe 40, 48149 Münster, Germany.
Armido
A
Studer