Regulation of Carbohydrate Metabolism, Lipid Metabolism, and Protein Metabolism by AMPK.
This chapter summarizes AMPK function in the regulation of substrate and energy metabolism with the main emphasis on carbohydrate and lipid metabolism, protein turnover, mitochondrial biogenesis, and whole-body energy homeostasis. AMPK acts as whole-body energy sensor and integrates different signaling pathway to meet both cellular and body energy requirements while inhibiting energy-consuming processes but also activating energy-producing ones. AMPK mainly promotes glucose and fatty acid catabolism, whereas it prevents protein, glycogen, and fatty acid synthesis.
Pole of Cardiovascular Research, Université catholique de Louvain, Institut de Recherche Expérimentale et Clinique, Brussels, Belgium.
Yeliz
Y
Angin
Pole of Cardiovascular Research, Université catholique de Louvain, Institut de Recherche Expérimentale et Clinique, Brussels, Belgium.|Division of Cardiology, Cliniques universitaires Saint-Luc, Brussels, Belgium.
Christophe
C
Beauloye
Pole of Cardiovascular Research, Université catholique de Louvain, Institut de Recherche Expérimentale et Clinique, Brussels, Belgium.
Sandrine
S
Horman
Pole of Cardiovascular Research, Université catholique de Louvain, Institut de Recherche Expérimentale et Clinique, Brussels, Belgium. luc.bertrand@uclouvain.be.
Luc
L
Bertrand
D055372:AMP-Activated Protein Kinases / Q000235:genetics* / Q000378:metabolism; D000103:Acetyl-CoA Carboxylase / Q000235:genetics / Q000378:metabolism; D000818:Animals; D005227:Fatty Acids / Q000378:metabolism; D005786:Gene Expression Regulation; D005943:Gluconeogenesis / Q000235:genetics*; D005947:Glucose / Q000378:metabolism; D006003:Glycogen / Q000378:metabolism; D006019:Glycolysis / Q000235:genetics*; D006801:Humans; D007333:Insulin Resistance / Q000235:genetics; D050155:Lipogenesis / Q000235:genetics*; D008066:Lipolysis / Q000235:genetics*; D001678:Organelle Biogenesis; D021122:Protein Subunits / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction
D005227:Fatty Acids; D021122:Protein Subunits; D006003:Glycogen; D055372:AMP-Activated Protein Kinases; D000103:Acetyl-CoA Carboxylase; D005947:Glucose
AMPK; Glucose metabolism; Insulin sensitivity; Lipid metabolism; Mitochondrial biogenesis; Protein synthesis