PEPlife: A Repository of the Half-life of Peptides.
Short half-life is one of the key challenges in the field of therapeutic peptides. Various studies have reported enhancement in the stability of peptides using methods like chemical modifications, D-amino acid substitution, cyclization, replacement of labile aminos acids, etc. In order to study this scattered data, there is a pressing need for a repository dedicated to the half-life of peptides. To fill this lacuna, we have developed PEPlife (http://crdd.osdd.net/raghava/peplife), a manually curated resource of experimentally determined half-life of peptides. PEPlife contains 2229 entries covering 1193 unique peptides. Each entry provides detailed information of the peptide, like its name, sequence, half-life, modifications, the experimental assay for determining half-life, biological nature and activity of the peptide. We also maintain SMILES and structures of peptides. We have incorporated web-based modules to offer user-friendly data searching and browsing in the database. PEPlife integrates numerous tools to perform various types of analysis such as BLAST, Smith-Waterman algorithm, GGSEARCH, Jalview and MUSTANG. PEPlife would augment the understanding of different factors that affect the half-life of peptides like modifications, sequence, length, route of delivery of the peptide, etc. We anticipate that PEPlife will be useful for the researchers working in the area of peptide-based therapeutics.
Bioinformatics Centre, CSIR-Institute of Microbial Technology, Chandigarh, India.
Deepika
D
Mathur
Bioinformatics Centre, CSIR-Institute of Microbial Technology, Chandigarh, India.
Satya
S
Prakash
Bioinformatics Centre, CSIR-Institute of Microbial Technology, Chandigarh, India.
Priya
P
Anand
Bioinformatics Centre, CSIR-Institute of Microbial Technology, Chandigarh, India.
Harpreet
H
Kaur
Bioinformatics Centre, CSIR-Institute of Microbial Technology, Chandigarh, India.
Piyush
P
Agrawal
Bioinformatics Centre, CSIR-Institute of Microbial Technology, Chandigarh, India.
Ayesha
A
Mehta
Bioinformatics Centre, CSIR-Institute of Microbial Technology, Chandigarh, India.
Rajesh
R
Kumar
Bioinformatics Centre, CSIR-Institute of Microbial Technology, Chandigarh, India.
Sandeep
S
Singh
Bioinformatics Centre, CSIR-Institute of Microbial Technology, Chandigarh, India.
Gajendra P S
GP
Raghava
D016208:Databases, Factual; D006207:Half-Life; D020407:Internet; D010455:Peptides / Q000378:metabolism*; D012984:Software; D014584:User-Computer Interface
D010455:Peptides