Gastrointestinal hormones and the gut connectome.
OBJECTIVE
Provision of adequate nutrients by the gut is essential for survival and essential behaviors are linked to the proper ingestion and digestion of food. Recently, a new neural connection has been reported between sensory cells of the gut epithelium and the nervous system that mediates signals from the gut to the brain.


RESULTS
This review describes how the gut senses its environment, relays those signals to the brain, and how the brain influences the gut.


CONCLUSIONS
This gut-brain connection provides a pathway for how the body handles food.
aDepartment of Medicine bDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, USA.
Lihua
L
Ye
Rodger A
RA
Liddle
D000818:Animals; D001921:Brain / Q000502:physiology*; D063132:Connectome; D004063:Digestion / Q000502:physiology; D004435:Eating; D019858:Enteroendocrine Cells / Q000502:physiology; D005768:Gastrointestinal Hormones / Q000502:physiology*; D000069196:Gastrointestinal Microbiome / Q000502:physiology; D041981:Gastrointestinal Tract / Q000294:innervation / Q000502:physiology*; D006801:Humans
D005768:Gastrointestinal Hormones