Modification of Mechanical Properties, Polymerization Temperature, and Handling Time of Polymethylmethacrylate Cement for Enhancing Applicability in Vertebroplasty.
Polymethylmethacrylate (PMMA) bone cement is a popular bone void filler for vertebroplasty. However, the use of PMMA has some drawbacks, including the material's excessive stiffness, exothermic polymerization, and short handling time. This study aimed to create an ideal modified bone cement to solve the above-mentioned problems. Modified bone cements were prepared by combining PMMA with three different volume fractions of castor oil (5%, 10%, and 15%). The peak polymerization temperatures, times to achieve the peak polymerization temperature, porosities, densities, modulus and maximum compression strengths of standard (without castor oil), and modified cements were investigated following storage at ambient temperature (22°C) or under precooling conditions (3°C). Six specimens were tested in each group of the aforementioned parameters. Increasing castor oil content and precooling treatment effectively decreased the peak polymerization temperatures and increased the duration to achieve the peak polymerization temperature (P< 0.05). Furthermore, the mechanical properties of the material, including density, modulus, and maximum compression strength, decreased with increasing castor oil content. However, preparation temperature (room temperature versus precooling) had no significant effect (P> 0.05) on these mechanical properties. In conclusion, the addition of castor oil to PMMA followed by precooling created an ideal modified bone cement with a low modulus, low polymerization temperature, and long handling time, enhancing its applicability and safety for vertebroplasty.
Department of Mechanical Engineering, Graduate Institute of Medical Mechatronics, Chang Gung University, Kweishan, Taoyuan, Taiwan; Department of Orthopedic Surgery, Bone and Joint Research Center, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kweishan, Taoyuan, Taiwan.
Ching-Lung
0000-0002-9084-4885
CL
Tai
Department of Orthopedic Surgery, Bone and Joint Research Center, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kweishan, Taoyuan, Taiwan.
Po-Liang
0000-0002-2020-919X
PL
Lai
Department of Orthopedic Surgery, Bone and Joint Research Center, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kweishan, Taoyuan, Taiwan.
Wei-De
0000-0003-2380-9104
WD
Lin
Department of Orthopedic Surgery, Bone and Joint Research Center, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kweishan, Taoyuan, Taiwan.
Tsung-Tin
TT
Tsai
Department of Mechanical Engineering, Graduate Institute of Medical Mechatronics, Chang Gung University, Kweishan, Taoyuan, Taiwan.
Yen-Chen
YC
Lee
Department of Mechanical Engineering, Graduate Institute of Medical Mechatronics, Chang Gung University, Kweishan, Taoyuan, Taiwan.
Mu-Yi
0000-0001-9424-8901
MY
Liu
Department of Orthopedic Surgery, Bone and Joint Research Center, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kweishan, Taoyuan, Taiwan.
Lih-Huei
LH
Chen
D000268:Adhesiveness; D001843:Bone Cements / Q000032:analysis / Q000138:chemical synthesis*; D002368:Castor Oil / Q000737:chemistry*; D019245:Compressive Strength; D055119:Elastic Modulus; D006244:Hardness; D008422:Materials Testing; D011108:Polymers / Q000138:chemical synthesis; D019904:Polymethyl Methacrylate / Q000032:analysis / Q000737:chemistry*; D013314:Stress, Mechanical; D013696:Temperature; D013718:Tensile Strength; D013997:Time Factors; D054854:Vertebroplasty / Q000379:methods*
D001843:Bone Cements; D011108:Polymers; D002368:Castor Oil; D019904:Polymethyl Methacrylate