SEOM clinical guidelines for the management of germ cell testicular cancer (2016).
Testicular cancer represents the most common malignancy in males aged 15-34 years and is considered a model of curable neoplasm. Maintaining success, reducing treatment burden, and focusing on survivorship are then key objectives. Inguinal orchiectomy is the first recommended maneuver that has both diagnostic and therapeutic aims. Most patients are diagnosed with stage I disease (confined to the testicle). Close surveillance and selective, short-course adjuvant chemotherapy are accepted alternatives for these cases. In patients with more advanced disease (stages II and III), 3-4 courses of cisplatin-based chemotherapy (according to IGCCCG risk classification) followed by the judicious surgical removal of residual masses represent the cornerstone of therapy. Poor-risk patients and those failing a first-line therapy should be referred to specialized tertiary centers. Paclitaxel-based conventional chemotherapy and high-dose chemotherapy plus autologous hematopoietic support can cure a proportion of patients with relapsing or refractory disease.
Servicio de Oncología Médica, Hospital Universitario y Politécnico La Fe, Av. Abril Martorell 106, 46026, Valencia, Spain. japariciou@seom.org.
J
J
Aparicio
Hospital Universitario Son Espases, Palma de Mallorca, Spain.
J
J
Terrasa
Instituto de Biomedicina de Sevilla, IBiS/Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Sevilla, Spain.
I
I
Durán
Institut Català d'Oncologia, ICO-IDIBELL L'Hospitalet, Barcelona, Spain.
J R
JR
Germà-Lluch
Hospital Lluis Alcanyis, Xátiva, Spain.
R
R
Gironés
Hospital Universitario Morales Meseguer-IMIB, Universidad Católica de Murcia-UCAM, Murcia, Spain.
E
E
González-Billalabeitia
Hospital Universitario Sant Joan de Reus, URV, IISPV, Reus, Spain.
J
J
Gumà
Hospital de Sant Pau, Barcelona, Spain.
P
P
Maroto
Hospital Universitario La Paz, Madrid, Spain.
A
A
Pinto
Institut Català d'Oncologia, ICO-IDIBELL L'Hospitalet, Barcelona, Spain.
X
X
García-Del-Muro
D000293:Adolescent; D000328:Adult; D006801:Humans; D008297:Male; D009367:Neoplasm Staging; D009373:Neoplasms, Germ Cell and Embryonal / Q000175:diagnosis* / Q000628:therapy*; D017410:Practice Guidelines as Topic; D012307:Risk Factors; D013030:Spain; D013736:Testicular Neoplasms / Q000175:diagnosis* / Q000628:therapy*; D055815:Young Adult
Chemotherapy; Germ-cell tumor; Surgery; Testicular cancer