Monocytopenia; Induction by Vinorelbine, Cisplatin and Doxorubicin in Breast, Non-Small Cell Lung and Cervix Cancer Patients.
BACKGROUND
The neoplasm is still a potential threat for breast, Non-Small Cell Lung (NSCL) and cervix cancer patients. Those gradually invade into other body organs, inducing complex pathological complications. Whereas, the anticancer drugs suppress the bone marrow, resulting serious hematological toxicities. Thus, the monocytic toxicity may the chance of infections, particularly in AID's patients.


OBJECTIVE
We aimed this retrospective study to investigate the monocytopenia induced by vinorelbine following chemotherapy in cancer patients.


METHODS
A total 60 adult cancer patients were divided into two groups; Group-1 patients received the treatment of Vinorelbine alone while group 2 patients received Vinorelbine based combination chemotherapy.


RESULTS
The overall comparison of mean monocyte count (×103per μl) with time showed a significant statistical difference (pvalue <0.001) for G-I and no significant difference for G-II (pvalue <0.08). The independent comparison of mean values for two groups at every week confirms the non-significant statistical difference during all of the five weeks (pvalues 0.551, 0.112, 0.559, 0.372, 0.468 respectively). In addition of that, the comparison of mean values observed before therapy with that of week 4 (after therapy) showed significant difference in G-I (pvalue <0.001) and non-significant in G-II (pvalue 0.053).


CONCLUSIONS
Monocytopenia is induced in both of the chemotherapy protocols allows the clinical oncologists and consultant physicians to select either of the chemotherapy protocol. The therapeutic efficacy should constitute the intervening consideration to treat the breast, cervix and NSCL (Non-Small Cell Lung's) cancers.
Biochemistry, Chemical Pathology, Molecular Biology Research Group, UMC&RC, University of Sargodha, Sargodha 40100 Pakistan. tahanazir@yahoo.com; Intellectual Consortium of Drug Discovery & Technology Development Inc., 937-Northumerland Ave, Saskatoon SK S7L3E4 Canada raonidataha@gmail.com.
Taha
T
Nazir
Intellectual Consortium of Drug Discovery & Technology Development Inc., 937-Northumerland Ave, Saskatoon SK S7L3E4 Canada raonidataha@gmail.com.
Nida
N
Taha
Department of Pathobiological Sciences, Louisiana State University, Baton Rouge, Louisiana 70803 USA. islam@lsu.edu.
Azahrul
A
Islam
INRS 531, boulevard des Prairies Laval (Québec) H7V 1B7 Canada suraj_ace@yahoo.com.
Suraj
S
Abraham
Department of Biosciences, COMSATS Institute of Information Technology, Islamabad, PO; 45550, Pakistan. adeel.mahmood@comsats.edu.pk.
Adeel
A
Mahmood
Operations Manager, Emirates Medical Services, Fujairah, UAE drmazhar@yahoo.com.
Mazhar
M
Mustafa
Breast Cancer; Cisplatin; Doxorubicin; Monocytopenia; NSCLC; Vinorelbine