Recurrence Rates and Risk Factors for Primary Giant Cell Tumors around the Knee: A Multicentre Retrospective Study in China.
Giant cell tumors of the bone (GCTBs) are commonly diagnosed in Asian populations, usually around the knee. Herein, we aimed to determine the clinical characteristics, local recurrence rates, and relevant risk factors of primary GCTB around the knee. Univariate and multivariate survival analyses were used to identify the risk factors for local recurrence. Four hundred ten patients with primary GCTB around the knee, treated between March 2000 and June 2014, were recruited from 7 institutions in China. The overall local recurrence rate was 23.4%, but was higher in patients aged 20-39 years (28.5%; P = 0.039). The local recurrence rate was the highest in patients treated with intralesional curettage (53.4%), and the lowest in those treated with resection (4.9%). We found a higher risk of tumor recurrence in the proximal fibula compared to the distal femur (hazard ratio: 28.52, 95% confidence interval: 5.88-138.39; P < 0.0001), and in patients treated with curettage compared to those treated with resection (hazard ratio: 12.07, 95% confidence interval: 4.99-29.18; P < 0.0001). Thus, the tumor location must be considered when selecting the optimal surgical treatment approach to reduce the risk of local recurrence and preserve joint function, especially in young patients.
Department of Orthopaedic Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Pan
P
Hu
Department of Oncology of Bone, Tianjin Hospital, Tianjin, China.|The Graduate School, Tianjin Medical University, Tianjin, China.
Liming
L
Zhao
Department of Oncology of Bone, Tianjin Hospital, Tianjin, China.|The Graduate School, Tianjin Medical University, Tianjin, China.
Huilin
H
Zhang
Department of Orthopedics, Jinan Military General Hospital, Jinan, China.
Xiuchun
X
Yu
Department of Orthopedics, Xijing Hospital, Forth Military Medical University, Xi'an, China.
Zhen
Z
Wang
Department of Orthopaedics, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China.
Zhaoming
Z
Ye
Department of Orthopaedics, Nanjing Military General Hospital, Nanjing, China.
Sujia
S
Wu
Department of Orthopaedics, The Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.
Shibing
S
Guo
Department of Oncology of Bone, The Third Hospital of Hebei Medical University, Shijiazhuang, China.
Guochuan
G
Zhang
Department of Epidemiology, Tianjin Neurological Institute, Tianjin, China.
Jinghua
J
Wang
Department of Epidemiology, Tianjin Neurological Institute, Tianjin, China.
Xianjia
X
Ning
Department of Oncology of Bone, Tianjin Hospital, Tianjin, China.
Yongcheng
Y
Hu
Department of Orthopaedic Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Yingze
Y
Zhang
D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D001859:Bone Neoplasms / Q000453:epidemiology* / Q000473:pathology / Q000601:surgery; D002681:China; D003475:Curettage; D005260:Female; D005360:Fibula / Q000473:pathology / Q000601:surgery; D018212:Giant Cell Tumor of Bone / Q000453:epidemiology* / Q000473:pathology / Q000601:surgery; D006801:Humans; D007717:Knee / Q000473:pathology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology* / Q000601:surgery; D012189:Retrospective Studies; D012307:Risk Factors; D055815:Young Adult