Two new arylalkenyl α,β-unsaturated δ-lactones with cytotoxic activity from the leaves and twigs of Cryptocarya concinna.
Tow new arylalkenyl α,β-unsaturated δ-lactones named cryptoconcatones K (1) and L (2) were obtained from the leaves and twigs of Cryptocarya concinna. Their structures were established on the basis of spectroscopic data (MS, 1D and 2D NMR). Compounds 1 and 2 showed cytotoxic activities with IC50values of 4.5 and 3.9 μM against Huh7 cancer cell line, respectively.
a State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry , China Pharmaceutical University , Nanjing , People's Republic of China.
Bing-Yuan
BY
Yang
a State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry , China Pharmaceutical University , Nanjing , People's Republic of China.
Ya-Min
YM
Shi
a State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry , China Pharmaceutical University , Nanjing , People's Republic of China.
Jian-Guang
JG
Luo
a State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry , China Pharmaceutical University , Nanjing , People's Republic of China.
Ling-Yi
LY
Kong
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D031369:Cryptocarya / Q000737:chemistry*; D006801:Humans; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D018515:Plant Leaves / Q000737:chemistry
D000972:Antineoplastic Agents, Phytogenic; D007783:Lactones
Cryptocarya concinna; Lauraceae; cytotoxic activities; α,β-unsaturated δ-lactones