Peri-Implant Crevicular Fluid Analysis, Enzymes and Biomarkers: a Systemetic Review.
OBJECTIVE
To review the current understanding of the biomarkers and enzymes associated with different forms peri-implant diseases and how their level changes influence the pathogenesis of the inflammatory diseases around dental implants.


METHODS
An electronic search in two different databases was performed including MEDLINE (PubMed) and EMBASE between 1996 to 2016. Human studies analyse peri-implant crevicular fluid (PICF) biomarker and enzyme levels of implants having peri-implant mucositis and peri-implantitis published in English language, were evaluated. A systematic review was performed to assess which biomarkers and enzymes in PICF were used to identify the inflammatory conditions around dental implants.


RESULTS
Fifty-one articles were identified of which 41 were further evaluated and included in the analysis. Due to significant heterogeneity between included studies, a meta-analysis could not be performed. Instead, a systematic descriptive review was performed.


CONCLUSIONS
Biomarkers and enzymes in peri-implant crevicular fluid have shown promising results in differentiating from peri-implant disease condition to health. However, due to inconsistent results and acquiring much evidence from cross-sectional studies, additional evidence supported by randomized-controlled trials is needed to validate the links reported.
Department of Periodontology, Faculty of Dentistry, Hacettepe University, Ankara Turkey.
Erhan
E
Dursun
Department of Periodontics, College of Dentistry, University of Illinois at Chicago, Chicago, Illinois USA.
Tolga Fikret
TF
Tözüm
biomarkers; dental implants; diagnosis; enzymes; inflammation