Gene expression of proteins of the vesicle cycle in the striatum and motor cortex under functional failure of nigrostriatal system.
Degeneration of dopaminergic neurons in the substantia nigra and the decrease in the dopamine level in the striatum lead to dysfunctions of motor behavior. This is accompanied by dysregulation of neuro-transmission in glutamatergic neurons of the motor cortex and GABA-ergic neurons of the striatum. It is shown that dysregulation of the gene expression of vesicle cycle proteins in neurons of the motor cortex occurs at an early (presymptomatic) stage of degeneration of the nigrostriatal system, and in more severe degeneration (symptomatic stage) the level of gene expression of vesicle cycle proteins in the striatum decreases.
Koltzov Institute of Developmental Biology, Russian Academy of Sciences, ul. Vavilova 26, Moscow, 119334, Russia. edik173@mail.ru.
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Mingazov
Koltzov Institute of Developmental Biology, Russian Academy of Sciences, ul. Vavilova 26, Moscow, 119334, Russia.
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Ugrumov
D033942:Adaptor Proteins, Vesicular Transport / Q000378:metabolism; D000818:Animals; D003342:Corpus Striatum / Q000378:metabolism*; D015870:Gene Expression; D007041:Hypoxanthine Phosphoribosyltransferase / Q000378:metabolism; D020267:MPTP Poisoning / Q000378:metabolism*; D008297:Male; D008810:Mice, Inbred C57BL; D009044:Motor Cortex / Q000378:metabolism*; D009410:Nerve Degeneration / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009474:Neurons / Q000378:metabolism*; D062706:Prodromal Symptoms; D012333:RNA, Messenger / Q000378:metabolism; D013378:Substantia Nigra / Q000378:metabolism*; D050863:Synaptotagmin I / Q000378:metabolism; D020696:rab5 GTP-Binding Proteins / Q000378:metabolism
D033942:Adaptor Proteins, Vesicular Transport; D009419:Nerve Tissue Proteins; D012333:RNA, Messenger; D050863:Synaptotagmin I; C494311:Syt1 protein, mouse; C095992:complexin I; C095993:complexin II; D007041:Hypoxanthine Phosphoribosyltransferase; D020696:rab5 GTP-Binding Proteins