Dynamin-related protein 1 (Drp1) mediating mitophagy contributes to the pathophysiology of nervous system diseases and brain injury.
As the main source of energy (celluar ATP) in eukaryotic cells, mitochondria are involved in cellular physiology and pathology. The balance of mitochondrial dynamic, fission and fusion regulated by quality control mechanisms, provides a guarantee for maintaining mitochondrial function, even celluar function. Worn out mitochondria would be removed through mitophagy which is regulated by autophagy related proteins and mitochondrial membrane proteins. Drp1, dynamic-related protein 1, is regarded as one of the most important proteins to evaluate mitochondrial fission mediating mitophagy in neurodegenerative diseases (eg. Alzheimer's, Parkinson's, Huntington's, amyotrophic lateral sclerosis) and heart failure. Recent studies have focused on the roles of Drp1 in ischemia-induced mitophagy in the hippocampal CA3 region, and traumatic brain injury (TBI)-induced cell death together with functional deficits. However, the exact mechanisms have not been well characterized. In this review, we will discuss and clarify the role of Drp1 and mitophagy in nervous system diseases and brain injury therein, with a special emphasis on their molecular mechanisms mediating mitochondrial dynamics and mitophagy.
Department of Forensic Medicine, Medical College of Soochow University, Suzhou, Jiangsu, R.P. China.
Qiong
Q
Wu
Department of Forensic Medicine, Medical College of Soochow University, Suzhou, Jiangsu, R.P. China. clluo@suda.edu.cn.
Cheng-Liang
CL
Luo
Department of Forensic Medicine, Medical College of Soochow University, Suzhou, Jiangsu, R.P. China. luyang.tao@163.com.
Lu-Yang
LY
Tao
D000818:Animals; D001343:Autophagy / Q000502:physiology; D001930:Brain Injuries / Q000378:metabolism* / Q000503:physiopathology; D034281:Dynamins; D020558:GTP Phosphohydrolases / Q000378:metabolism*; D006801:Humans; D008869:Microtubule-Associated Proteins / Q000378:metabolism*; D024101:Mitochondrial Proteins / Q000378:metabolism*; D063306:Mitophagy / Q000502:physiology*; D019636:Neurodegenerative Diseases / Q000378:metabolism* / Q000503:physiopathology
D008869:Microtubule-Associated Proteins; D024101:Mitochondrial Proteins; D020558:GTP Phosphohydrolases; C110768:DNM1L protein, human; D034281:Dynamins