Iron Overload and Platelet Function Defects: Possible Correlation.
Acquired platelet function defect might be a consequence of iron overload. Even though there are various complications of iron overload, only few reports have indicated some correlations with platelets dysfunction. We report a child with Diamond-Blackfan anemia who has significant complications from iron overload due to chronic blood transfusion, and one of these complications is acquired platelet function defect that manifests with frequent episodes of epistaxis. Therefore, we emphasize the necessity for further studies to confirm direct correlation between iron overload as a causative agent and platelets dysfunction. And we recommend screening for platelets function in patients receiving chronic blood transfusion aiming at possible prevention of any life-threatening bleeding.
King Salman Armed Forces Hospital, Tabuk, Kingdom of Saudi Arabia.
Abdulkader A
AA
Dahi
King Salman Armed Forces Hospital, Tabuk, Kingdom of Saudi Arabia.
Ehab
E
Hanafy
King Salman Armed Forces Hospital, Tabuk, Kingdom of Saudi Arabia.
Mohammed
M
Al Pakra
acquired platelet function defect; blood transfusion; hemochromatosis; iron overload