Extrinsic and Intrinsic Regulation of Axon Regeneration by MicroRNAs after Spinal Cord Injury.
Spinal cord injury is a devastating disease which disrupts the connections between the brain and spinal cord, often resulting in the loss of sensory and motor function below the lesion site. Most injured neurons fail to regenerate in the central nervous system after injury. Multiple intrinsic and extrinsic factors contribute to the general failure of axonal regeneration after injury. MicroRNAs can modulate multiple genes' expression and are tightly controlled during nerve development or the injury process. Evidence has demonstrated that microRNAs and their signaling pathways play important roles in mediating axon regeneration and glial scar formation after spinal cord injury. This article reviews the role and mechanism of differentially expressed microRNAs in regulating axon regeneration and glial scar formation after spinal cord injury, as well as their therapeutic potential for promoting axonal regeneration and repair of the injured spinal cord.
State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; Department of Spine Surgery, Xiangya Hospital, Central South University, Changsha 410008, China.
Ping
P
Li
State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; Savaid Medical School, University of Chinese Academy of Sciences, Beijing 100049, China.
Zhao-Qian
ZQ
Teng
State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; Savaid Medical School, University of Chinese Academy of Sciences, Beijing 100049, China.
Chang-Mei
0000-0002-2941-4667
CM
Liu
D000818:Animals; D001369:Axons / Q000502:physiology*; D004195:Disease Models, Animal; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D009416:Nerve Regeneration / Q000235:genetics* / Q000502:physiology; D009474:Neurons / Q000502:physiology*; D020127:Recovery of Function / Q000502:physiology*; D013119:Spinal Cord Injuries / Q000235:genetics* / Q000503:physiopathology
D035683:MicroRNAs