Synthesis, in-vitro cytotoxicity of 1H-benzo[f]chromene derivatives and structure-activity relationships of the 1-aryl group and 9-position.
A series of 1H-benzo[f]chromene-2-carbonitriles was synthesized and evaluated for their cytotoxic activities against MCF-7, HCT-116, and HepG-2 cancer cells. The SAR studies reported that the substitution in the phenyl ring at 1-position of 1H-benzo[f]chromene nucleus with the specific group, H atom, or methoxy group at 9-position increases the ability of the molecule against the different cell lines.
Chemistry Department, Faculty of Science, Al-Azhar University, 11884 Nasr City, Cairo, Egypt.
Hany M
HM
Mohamed
Chemistry Department, Faculty of Science, King Khalid University, Abha, 61413, P.O. Box Abha 9004, Saudi Arabia.
Ahmed M
AM
Fouda
Chemistry Department, Faculty of Science, Al-Azhar University, 11884 Nasr City, Cairo, Egypt.
Essam S A E H
ESAEH
Khattab
Chemistry Department, Faculty of Science, Al-Azhar University, 11884 Nasr City, Cairo, Egypt.
Ahmed M El-
AME
Agrody
Chemistry department, Faculty of Science, Taibah University, 30002, Al-Madinah Al-Munawarah, Saudi Arabia.
Tarek H
TH
Afifi
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001578:Benzopyrans / Q000138:chemical synthesis* / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D015195:Drug Design; D045325:HCT116 Cells; D056945:Hep G2 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D061986:MCF-7 Cells; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D001578:Benzopyrans
1H-benzo[f]chromenes; SAR; antitumor activity; microwave synthesis