The Epidemic History of HIV-1 CRF07_BC in Hetian Prefecture and the Role of It on HIV Spreading in China.
CRF07_BC is one of the most prevalent HIV-1 strains in China, and Xinjiang Uygur Autonomous Region has ever been considered to be a second epidemic center after Yunnan Province in previous studies. Here we use HIV-1 pol gene sequences identified from Hetian Prefecture located in Xinjiang Autonomous Region to reconstruct the epidemic history of HIV CRF07_BC strain circulating in this region. We found that CRF07_BC is the predominant HIV-1 form in Hetian Prefecture, and the estimated tMRCA analysis shows that there is no enough evidence supporting Xinjiang Autonomous Region as a second epidemic center of spreading HIV-1. It may imply that every city may be only a point among the HIV spreading network because of the frequent migration of population in the whole country nowadays.
1 Anhui Provincial Center for Disease Control and Prevention , Hefei, China .
Jianjun
J
Wu
2 Jiangsu Provincial Center for Disease Control and Prevention , Nanjing, China .
Hongxiong
H
Guo
3 Hetian Prefecture Center for Disease Control and Prevention , Hetian, China .
Jing
J
Zhang
3 Hetian Prefecture Center for Disease Control and Prevention , Hetian, China .
Xiaoming
X
Liu
3 Hetian Prefecture Center for Disease Control and Prevention , Hetian, China .
Aideaierli
A
Ayoupu
1 Anhui Provincial Center for Disease Control and Prevention , Hefei, China .
Yuelan
Y
Shen
1 Anhui Provincial Center for Disease Control and Prevention , Hefei, China .
Lifeng
L
Miao
1 Anhui Provincial Center for Disease Control and Prevention , Hefei, China .
Jihai
J
Tang
4 Hefei Center for Disease Control and Prevention , Hefei, China .
Yanhua
Y
Lei
1 Anhui Provincial Center for Disease Control and Prevention , Hefei, China .
Bin
B
Su
D000328:Adult; D002681:China / Q000453:epidemiology; D018562:Disease Transmission, Infectious; D058872:Epidemics; D005260:Female; D005838:Genotype; D015658:HIV Infections / Q000453:epidemiology* / Q000635:transmission*; D015497:HIV-1 / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008875:Middle Aged; D017720:Molecular Epidemiology; D015995:Prevalence; D017422:Sequence Analysis, DNA; D055815:Young Adult; D054302:pol Gene Products, Human Immunodeficiency Virus
D054302:pol Gene Products, Human Immunodeficiency Virus
CRF07_BC; HIV-1; Hetian Prefecture; diversity; viral evolution