Cuspidate A, new anti-fungal triterpenoid saponin from Lepidagathis cuspidata.
One new triterpenoid saponin named cuspidate A (1) along with a known oleanane-based triterpenoid saponin clemontanoside-C were isolated from the roots of Lepidagathis cuspidata. The structure of new compound (1) was established after detailed analysis of spectroscopic data including 1D and 2D NMR spectra. This is the first report on clemontanoside-C from this genus. These saponins were found to be effective against the selected fungal strains Aspergillus flavus, Rhizopus stolinifer, Penicillum nodatum, Aspergillus fumigates. Compound 1 showed better activity, comparable to the synthetic drug, while compound 2 showed a moderate effect against all studied fungal strains.
a Department of Chemistry, Government Post Graduate College Dhaliara , Himachal Pradesh University , Shimla , India.
Rajeev
R
Rattan
b Department of Chemistry, School of Sciences , Indira Gandhi National Open University , New Delhi , India.
Bharat
B
Inder Fozdar
a Department of Chemistry, Government Post Graduate College Dhaliara , Himachal Pradesh University , Shimla , India.
Veena
V
Gautam
c Natural Product Chemistry and Process Development Division , CSIR-Institute of Himalayan Bioresource Technology , Palampur , India.|d CSIR , Academy of Scientific and Innovative Research , New Delhi , India.
Ritika
R
Sharma
c Natural Product Chemistry and Process Development Division , CSIR-Institute of Himalayan Bioresource Technology , Palampur , India.|d CSIR , Academy of Scientific and Innovative Research , New Delhi , India.
Dinesh
D
Kumar
c Natural Product Chemistry and Process Development Division , CSIR-Institute of Himalayan Bioresource Technology , Palampur , India.|d CSIR , Academy of Scientific and Innovative Research , New Delhi , India.
Upendra
U
Sharma
D027901:Acanthaceae / Q000737:chemistry*; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001232:Aspergillus fumigatus / Q000187:drug effects; D004353:Drug Evaluation, Preclinical / Q000379:methods; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009828:Oleanolic Acid / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification; D010407:Penicillium / Q000187:drug effects; D010935:Plant Diseases / Q000382:microbiology; D018517:Plant Roots / Q000737:chemistry; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
D000935:Antifungal Agents; D012503:Saponins; D014315:Triterpenes; C000618951:cuspidate A; C413246:oleanane; D009828:Oleanolic Acid; C082271:clemontanoside C
Lepidagathis cuspidata; anti-fungal; triterpenoid saponins