Metabolic Control of Cellular Differentiation.
The role of metabolic rewiring during cellular differentiation is under intense investigation. Reporting recently in Science, Peng et al. (2016) found that activation of glycolysis supports T helper cell differentiation by controlling acetyl-coA and histone acetylation levels, identifying a link between metabolic state and epigenetic control of gene activity.
Cancer Metabolism Research Unit, Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK; Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Glasgow G61 1QH, UK.
Vinay
V
Bulusu
Developmental Biology Unit, European Molecular Biology Laboratory, Meyerhofstraße 1, Heidelberg 69117, Germany. Electronic address: aulehla@embl.de.
Alexander
A
Aulehla
D000105:Acetyl Coenzyme A / Q000235:genetics*; D000107:Acetylation; D002454:Cell Differentiation; D006657:Histones / Q000235:genetics*; D011499:Protein Processing, Post-Translational
D006657:Histones; D000105:Acetyl Coenzyme A