Encapsulation of NSAIDs for inflammation management: Overview, progress, challenges and prospects.
Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most widely prescribed drugs. Debilitating diseases such as rheumatoid arthritis and osteoarthritis are commonly managed by NSAIDs. However, NSAIDs pharmacological mechanism is often associated with the presence of gastrointestinal side effects. NSAIDs encapsulation is performed in order to overcome some of the drawbacks linked to their clinical use. To fulfill this purpose, various vectors like polymer-based nanoparticles, liposomes and solid lipid nanoparticles have been proposed. Such vehicles could have advantages but some limitations as well. This manuscript highlights current NSAIDs encapsulation approaches based on either preformed polymers or lipids. Moreover, properties of the prepared carriers and their applications are also discussed. Many factors are taken into account for selecting carrier type and encapsulation method. It was concluded that different vehicles and preparation methods have been employed for NSAIDs encapsulation. Mostly, vehicles sizes ranged within the nanoscale. Main advantages that have been confirmed by in vitro and in vivo studies include promoted stability, sustained release and bioavailability enhancement.
Univ Lyon, CNRS, UMR-5007, LAGEP, F-69622, Lyon, France; Faculty of Pharmacy, Kabul University, Kabul, Afghanistan.
Waisudin
W
Badri
Univ Lyon, CNRS, UMR-5007, LAGEP, F-69622, Lyon, France.
Karim
K
Miladi
Faculty of Pharmacy, Kabul University, Kabul, Afghanistan.
Qand Agha
QA
Nazari
Faculty of Sciences, Lebanese University, Lebanon.
Hélène
H
Greige-Gerges
Univ Lyon, CNRS, UMR-5007, LAGEP, F-69622, Lyon, France.
Hatem
H
Fessi
Univ Lyon, CNRS, UMR-5007, LAGEP, F-69622, Lyon, France. Electronic address: elaissari@lagep.univ-lyon1.fr.
Abdelhamid
A
Elaissari
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry* / Q000627:therapeutic use*; D006801:Humans; D007249:Inflammation / Q000188:drug therapy*; D008055:Lipids / Q000737:chemistry; D008081:Liposomes / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry; D010316:Particle Size; D011108:Polymers / Q000737:chemistry
D000894:Anti-Inflammatory Agents, Non-Steroidal; D008055:Lipids; D008081:Liposomes; D011108:Polymers
Carriers; Encapsulation; In vivo; Liposomes; Non-steroidal anti-inflammatory drugs; Particles; Solid lipid nanoparticles