Structural Modifications of Matrine-Type Alkaloids.
Matrine-type alkaloids belong to quinolizidine analogues from Sophora flavescens Ait, Sophora subprostrata and Sophora alopecuroides L. possess numerous therapeutic properties and have attracted continuous attention over the past few decades. In order to improve the activities and amplify their applicants, many matrine-type derivatives have synthesized and evaluated for their biological activities in recent years. These structural modifications have resulted in stronger activities and improvement of the pharmacokinetic properties. The structure and activity relation studies based on matrine- type semi-synthetic derivatives have immensely contributed to the understanding of their mechanism of actions and molecular targets. This review mainly summarizes recent progress in the structural modifications of matrine-type alkaloids based on the alteration of C-13 or C-14 position, opening D ring, fusing D ring and structural simplification.
National School of Medicine, Guizhou Minzhu University, Guiyang 550025, China.
Xiao-Hua
XH
Cai
College of Pharmaceutical Sciences, Zhejiang Technology University, Hangzhou 310014, China.
Hui
H
Guo
National School of Medicine, Guizhou Minzhu University, Guiyang 550025, China.
Bing
B
Xie
D000470:Alkaloids / Q000737:chemistry* / Q000494:pharmacology; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D015394:Molecular Structure; D011807:Quinolizines / Q000737:chemistry* / Q000494:pharmacology; D029909:Sophora / Q000737:chemistry*; D000093842:Matrines
D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D011807:Quinolizines; D000093842:Matrines
Bioactivities; Chinese traditional medicine; matrine; matrine-type alkaloids; sophoridine; structural modifications.