Accrual to Cancer Clinical Trial.
Accrual to cancer clinical trials (CCT) is imperative to safeguard continued improvement in cancer outcomes. A retrospective chart review was performed of patients (n=140) starting a new anti-cancer agent in a north Dublin cancer centre. This review was performed over a four-month period, beginning in November 2015. Only 29% (n=41) had a CCT option. The overall accrual rate to CCT was 5% (n=7), which is comparable to internationally reported figures. The main reasons for failure to recruit to CCT included the lack of a CCT option for cancer type (n=30, 23%), stage (n=25, 19%), and line of treatment (n=23, 17%). Over the last decade, the rate of accrual to CCTs has in fact doubled and the number of trials open to recruitment has tripled. Ongoing governmental and philanthropic support is necessary to continue this trend to further expand CCT patient options with a target accrual rate of 10%.
Department of Medical Oncology, Mater Misericordiae University Hospital, Eccles St, Dublin 7.
C
C
Kelly
Department of Medical Oncology, Mater Misericordiae University Hospital, Eccles St, Dublin 7.
M
M
Smith
Department of Medical Oncology, Mater Misericordiae University Hospital, Eccles St, Dublin 7.
S
S
Flynn
Department of Medical Oncology, Mater Misericordiae University Hospital, Eccles St, Dublin 7.
A
A
Reyes
Department of Medical Oncology, Mater Misericordiae University Hospital, Eccles St, Dublin 7.
M
M
Higgins
Department of Medical Oncology, Mater Misericordiae University Hospital, Eccles St, Dublin 7.
J
J
McCaffrey
Department of Medical Oncology, Mater Misericordiae University Hospital, Eccles St, Dublin 7.
C
C
Kelly
D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*; D018579:Patient Selection; D012189:Retrospective Studies
D000970:Antineoplastic Agents