A database on the stability of silver and gold nanostructures for applications in biology and biomolecular sciences.
Colloidal stability of nanoparticles in biological media is an important consideration when trying to ensure reliable data interpretation of in vitro and in vivo systems. We have developed a detailed colloidal stability library of newly synthesized gold, silver and gold-core silver-shell plasmonic nanoparticles, stabilized with aspartame, glucosamine and sucralose, in various biologically relevant buffers and bacterial and mammalian cell culture media. The stabilizer selection reflects the preference for molecules that are non-toxic, inexpensive, readily available, water soluble and easy-to-replace if that is the end-user preference. An on-line resource provides detailed stability information on each of the 81 systems examined. To illustrate how to utilize this stability library, we conducted bacterial toxicity and biocompatibility experiments through the use of one specific set of nanomaterials in the presence and absence of plasmonic irradiation.
Department of Chemistry and Biomolecular Sciences and Centre for Catalysis Research and Innovation, University of Ottawa, Ontario, CanadaK1N 6N5. titoscaiano@mac.com.
Hasitha de Alwis
HA
Weerasekera
Department of Chemistry and Biomolecular Sciences and Centre for Catalysis Research and Innovation, University of Ottawa, Ontario, CanadaK1N 6N5. titoscaiano@mac.com and Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, 5000 Córdoba, Argentina and Instituto Multidisciplinario de Biología Vegetal (CONICET), Departamento de Farmacia, Universidad Nacional de Córdoba, 5000 Córdoba, Argentina.
María Jazmín
MJ
Silvero
Department of Chemistry and Biomolecular Sciences and Centre for Catalysis Research and Innovation, University of Ottawa, Ontario, CanadaK1N 6N5. titoscaiano@mac.com.
Daliane
D
Regis Correa da Silva
Department of Chemistry and Biomolecular Sciences and Centre for Catalysis Research and Innovation, University of Ottawa, Ontario, CanadaK1N 6N5. titoscaiano@mac.com.
Juan C
JC
Scaiano
D000818:Animals; D062126:Databases, Chemical; D006046:Gold; D053768:Metal Nanoparticles / Q000737:chemistry*; D049329:Nanostructures / Q000737:chemistry*; D012834:Silver; D054852:Small Molecule Libraries
D054852:Small Molecule Libraries; D012834:Silver; D006046:Gold