Disadvantage of survival outcomes in widowed patients with colorectal neuroendocrine neoplasm: an analysis of surveillance, epidemiology and end results database.
Marital status correlates with health. Our goal was to examine the impact of marital status on the survival outcomes of patients with colorectal neuroendocrine neoplasms (NENs). The Surveillance, Epidemiology and End Results program was used to identify 1,289 eligible patients diagnosed between 2004 and 2010 with colorectal NENs. Statistical analyses were performed using Chi-square, Kaplan-Meier, and Cox regression proportional hazards methods. Patients in the widowed group had the highest proportion of larger tumor (>2cm), and higher ratio of poor grade (Grade III and IV) and more tumors at advanced stage (P<0.05). The 5-year cause specific survival (CSS) was 76% in the married group, 51% in the widowed group, 73% in the single group, and 72% in the divorced/separated group, which manifest statistically significant difference in the univariate log-rank test and Cox regression model (P<0.05). Furthermore, marital status was an independent prognostic factor only in Distant stage (P<0.001). In conclusion, patients in widowed group were at greater risk of cancer specific mortality from colorectal NENs and social support may lead to improved outcomes for patients with NENs.
Department of Oncology, Yangzhou NO.1 People's Hospital, The Second Clinical School of Yangzhou University, Yangzhou, Jiangsu Province, China.|Research Center of Cancer Prevention and Treatment, Medical College of Yangzhou University, Yangzhou, Jiangsu Province, China.
Jing
J
Li
Department of Oncology, Yangzhou NO.1 People's Hospital, The Second Clinical School of Yangzhou University, Yangzhou, Jiangsu Province, China.
Ying
Y
Wang
Department of Oncology, Yangzhou NO.1 People's Hospital, The Second Clinical School of Yangzhou University, Yangzhou, Jiangsu Province, China.
Fang
F
Han
Department of Oncology, Yangzhou NO.1 People's Hospital, The Second Clinical School of Yangzhou University, Yangzhou, Jiangsu Province, China.
Zhu
Z
Wang
Research Center of Cancer Prevention and Treatment, Medical College of Yangzhou University, Yangzhou, Jiangsu Province, China.
Lichun
L
Xu
Department of Oncology, Yangzhou NO.1 People's Hospital, The Second Clinical School of Yangzhou University, Yangzhou, Jiangsu Province, China.
Jiandong
J
Tong
D018278:Carcinoma, Neuroendocrine / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D016009:Chi-Square Distribution; D015179:Colorectal Neoplasms / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D004243:Divorce; D005260:Female; D006304:Health Status; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D016016:Proportional Hazards Models; D018570:Risk Assessment; D012307:Risk Factors; D018426:SEER Program; D012847:Single Person; D012944:Social Support; D013997:Time Factors; D016896:Treatment Outcome; D047368:Tumor Burden; D014481:United States / Q000453:epidemiology; D017805:Widowhood
colorectal neuroendocrine neoplasms; marital status; prognostic analysis