Glucose Hypermetabolism in Contralateral Basal Ganglia Demonstrated by Serial FDG PET/CT Scans in a Patient With SLE Chorea.
We reported a 24-year-old woman who developed a movement disorder of mouth and limbs during systemic lupus erythematosus. Brain MRI did not find any abnormalities. Increased FDG uptake in basal ganglia was found using FDG PET/CT brain scan. The symptoms remitted after therapy and the activities of the original hypermetabolic regions were down to normal in the follow-up FDG PET/CT scan. This case implies that the pathophysiology of chorea in systemic lupus erythematosus is different from that of chorea in other diseases, such as Huntington disease and chorea-acanthocytosis, in which hypometabolic basal ganglia was found.
From the Department of Nuclear Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, People's Republic of China.
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D001479:Basal Ganglia / Q000000981:diagnostic imaging* / Q000378:metabolism; D002819:Chorea / Q000000981:diagnostic imaging* / Q000209:etiology / Q000378:metabolism; D005260:Female; D019788:Fluorodeoxyglucose F18; D007839:Functional Laterality; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D020945:Lupus Vasculitis, Central Nervous System / Q000150:complications / Q000000981:diagnostic imaging* / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D000072078:Positron Emission Tomography Computed Tomography; D019275:Radiopharmaceuticals; D055815:Young Adult
D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D005947:Glucose