Naringin promotes fracture healing through stimulation of angiogenesis by regulating the VEGF/VEGFR-2 signaling pathway in osteoporotic rats.
Postmenopausal osteoporosis is characterized by a reduction in the number of sinusoidal and arterial capillaries in the bone marrow and reduced bone perfusion. Thus, osteogenesis and angiogenesis are coupled in the process of osteoporosis formation and fracture healing. Naringin is the main ingredient of the root Rhizoma Drynariae, a traditional Chinese medicine, and it has potential effects on promoting fracture healing. However, whether naringin stimulates angiogenesis in the process of bone healing is unclear. Here, we show that naringin promotes fracture healing through stimulating angiogenesis by regulating the VEGF/VEGFR-2 signaling pathway in osteoporotic rats.
Tianjin Huanhu Hospital, No. 6 Jizao Road, Jinnan District, Tianjin, 300350, China.
Nan
N
Song
Tianjin Institute of Orthopedics in Traditional Chinese and Western Medicine, No. 122, Munan Road, Tianjin, 300050, China; Graduate School of Tianjin Medical University, Tianjin, China.
Zhihu
Z
Zhao
Tianjin Institute of Orthopedics in Traditional Chinese and Western Medicine, No. 122, Munan Road, Tianjin, 300050, China. Electronic address: gukezzh@126.com.
Xinlong
X
Ma
Tianjin Institute of Orthopedics in Traditional Chinese and Western Medicine, No. 122, Munan Road, Tianjin, 300050, China.
Xiaolei
X
Sun
Tianjin Institute of Orthopedics in Traditional Chinese and Western Medicine, No. 122, Munan Road, Tianjin, 300050, China.
Jianxiong
J
Ma
Tianjin Institute of Orthopedics in Traditional Chinese and Western Medicine, No. 122, Munan Road, Tianjin, 300050, China.
Fengbo
F
Li
Tianjin Institute of Orthopedics in Traditional Chinese and Western Medicine, No. 122, Munan Road, Tianjin, 300050, China.
Lei
L
Sun
Tianjin Institute of Orthopedics in Traditional Chinese and Western Medicine, No. 122, Munan Road, Tianjin, 300050, China.
Jianwei
J
Lv
D000818:Animals; D015519:Bone Density / Q000187:drug effects; D002146:Bony Callus / Q000187:drug effects / Q000473:pathology; D005260:Female; D044950:Flavanones / Q000494:pharmacology*; D017102:Fracture Healing / Q000187:drug effects*; D005786:Gene Expression Regulation / Q000187:drug effects; D007150:Immunohistochemistry; D018919:Neovascularization, Physiologic / Q000187:drug effects*; D010011:Osteocytes / Q000187:drug effects / Q000378:metabolism; D010024:Osteoporosis / Q000378:metabolism*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D017207:Rats, Sprague-Dawley; D015398:Signal Transduction / Q000187:drug effects*; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics / Q000378:metabolism*; D040301:Vascular Endothelial Growth Factor Receptor-2 / Q000235:genetics / Q000378:metabolism*
D044950:Flavanones; D012333:RNA, Messenger; D042461:Vascular Endothelial Growth Factor A; D040301:Vascular Endothelial Growth Factor Receptor-2; C005274:naringin
Angiogenesis; Naringin; VEGF; VEGFR-2