1,6-Conjugate addition of zinc alkyls to para-quinone methides in a continuous-flow microreactor.
An efficient method for the synthesis of alkyl diarylmethanes through the 1,6-conjugate addition of dialkylzinc reagents to para-quinone methides (p-QMs) has been developed under continuous flow conditions using a microreactor. This protocol allows to access unsymmetrical alkyl diarylmethanes in moderate to excellent yields using a wide range of p-QMs and dialkylzinc reagents. Interestingly, this transformation worked well without the requirement of a catalyst.
Department of Chemical Sciences, Indian Institute of Science Education and Research (IISER) Mohali, Sector 81, Knowledge City, S. A. S. Nagar, Manauli (PO), Punjab 140306, India. rvijayan@iisermohali.ac.in.
Abhijeet S
AS
Jadhav
Department of Chemical Sciences, Indian Institute of Science Education and Research (IISER) Mohali, Sector 81, Knowledge City, S. A. S. Nagar, Manauli (PO), Punjab 140306, India. rvijayan@iisermohali.ac.in.
Ramasamy Vijaya
http://orcid.org/0000-0001-9490-4569
RV
Anand