[SENTIERI-ReNaM: Burden of disease from mesothelioma in national priority contaminated sites in Italy].
BACKGROUND
in Italy, National Priority Contaminated Sites (NPCSs) are defined as of concern for remediation; most of them are sites with a long-lasting industrial activity.


OBJECTIVE
the study aims to estimate the burden of disease from mesothelioma in NPCSs.


METHODS
mesothelioma incidence in the period 2000-2011 was estimated for the populations residing in the 39 Italian NPCSs. Data were taken from the Italian National Mesothelioma Registry (ReNaM). NPCSs were ranked into risk groups (RGs) on the basis of the presence of the following asbestos-exposing activities: 1. asbestos-cement plants; 2. asbestos mines; 3. harbours with shipyards; 4. illegal dumping sites containing asbestos; 5. petrochemicals and/or refineries, and/or steel plants; 6. chemical plants and/or landfills without explicit mention of asbestos. For the population residing in each NPCS, crude rates per 100,000 per year and number of observed minus expected cases (Obs-Exp) by gender were computed. Expected cases were calculated using the age-class rates of a reference population (the geographical macroarea of every NPCS). For every RG, the meta-analytic estimate of the attributable proportion (AP), i.e., the proportion of cases attributable to the local context, was computed, being the AP for each NPCS expressed as (Obs-Exp/Obs) x100.


RESULTS
the total number of mesothelioma cases estimated in the considered period of 12 years is 2,741 (2,048 males, 693 females). The total number of Obs-Exp cases was 1,531 (1,178 in males, 353 in females). In males, crude rate ranges from 71.5 in the RG1 to 3.0 in RG4, while in females it ranges from 48.4 in RG1 to 0.6 in RG4. In males, AP in RGs from 1 to 3 is over 65%, in RG4 is 59%, in RG5 is 30%, in RG6 is -14%. AP in females gradually drops from 95% in RG1 to -64% in RG6.


CONCLUSIONS
the burden of mesothelioma in populations residing in NPCSs is high, with an AP gradient consistent with the a priori RG. This burden impacts on females in a different way: rates are lower than male ones; AP is similar to male ones in the RGs 1 and 3.
Dipartimento di ambiente e connessa prevenzione primaria, Istituto superiore di sanità, Roma.
Roberto
R
Pasetto
Dipartimento di ambiente e connessa prevenzione primaria, Istituto superiore di sanità, Roma.
Lucia
L
Fazzo
Dipartimento di ambiente e connessa prevenzione primaria, Istituto superiore di sanità, Roma. amerigo.zona@iss.it.
Amerigo
A
Zona
Dipartimento di ambiente e connessa prevenzione primaria, Istituto superiore di sanità, Roma.
Caterina
C
Bruno
Dipartimento di biologia e biotecnologie "Charles Darwin", Sapienza Università di Roma.
Roberta
R
Pirastu
Dipartimento di medicina, epidemiologia, igiene del lavoro e ambientale, Istituto nazionale per l'assicurazione contro gli infortuni sul lavoro, Roma.
Alessandra
A
Binazzi
Dipartimento di medicina, epidemiologia, igiene del lavoro e ambientale, Istituto nazionale per l'assicurazione contro gli infortuni sul lavoro, Roma.
Marisa
M
Corfiati
Collaboratore Istituto per lo studio e la prevenzione oncologica, Firenze.
Stefano
S
Silvestri
Dipartimento di ambiente e connessa prevenzione primaria, Istituto superiore di sanità, Roma.
Pietro
P
Comba
Dipartimento di medicina, epidemiologia, igiene del lavoro ed ambientale, Istituto nazionale per l'assicurazione contro gli infortuni sul lavoro, Roma.
Alessandro
A
Marinaccio
D001194:Asbestos / Q000633:toxicity; D002274:Carcinogens, Environmental / Q000633:toxicity; D016001:Confidence Intervals; D004781:Environmental Exposure; D004787:Environmental Pollution; D005260:Female; D064371:Hazardous Waste Sites; D006306:Health Surveys; D006801:Humans; D015994:Incidence; D007221:Industry; D007558:Italy; D008297:Male; D008654:Mesothelioma / Q000453:epidemiology* / Q000209:etiology; D016273:Occupational Exposure; D012042:Registries; D012306:Risk
D002274:Carcinogens, Environmental; D001194:Asbestos