Salmonella Gives MARCH(ing) Orders to MHC-II.
How bacterial pathogens evade adaptive immunity is not well understood. In this issue of Cell Host & Microbe, Bayer-Santos et al. (2016) show that the Salmonella effector protein SteD mediates MARCH8-dependent ubiquitination of class II MHC molecules, thereby inhibiting antigen presentation and limiting T cell responses.
Department of Molecular Genetics and Microbiology and Center for Infectious Diseases, 130 Life Sciences Building, Stony Brook University, Stony Brook, NY 11794-5120, USA.
Patrick A
PA
McLaughlin
Department of Molecular Genetics and Microbiology and Center for Infectious Diseases, 130 Life Sciences Building, Stony Brook University, Stony Brook, NY 11794-5120, USA. Electronic address: a.vandervelden@stonybrook.edu.
Adrianus W M
AWM
van der Velden
D017951:Antigen Presentation; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D012475:Salmonella; D013601:T-Lymphocytes / Q000276:immunology; D054875:Ubiquitination
D000949:Histocompatibility Antigens Class II