The inhibition of dopamine synthesis in fetuses changes the pattern of T-lymphocyte maturation in the thymus of adult rats.
The mRNA for dopamine receptors of type D1, D3, D5, but not type D2, was detected in the thymus of rats starting from day 16 of embryonic development (E16). Dopamine at concentrations of 10-8-10‒6M inhibited fetus thymocyte response to mitogen, confirming the functionality of the receptors and the possibility of a direct effect of dopamine on the developing thymus. Pharmacological inhibition of catecholamine synthesis in the crucial period of thymus development leads to long-term changes in the T-system immunity due to increased production of natural regulatory T-lymphocytes. The presence and functional activity of dopamine receptors in the fetal thymus indicates its ability to influence the development of the immune system of rats during ontogeny.
Koltzov Institute of Developmental Biology, Russian Academy of Sciences, ul. Vavilova 26, Moscow, 119334, Russia.
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Lifantseva
Koltzov Institute of Developmental Biology, Russian Academy of Sciences, ul. Vavilova 26, Moscow, 119334, Russia.
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Koneeva
Koltzov Institute of Developmental Biology, Russian Academy of Sciences, ul. Vavilova 26, Moscow, 119334, Russia.
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Voronova
Koltzov Institute of Developmental Biology, Russian Academy of Sciences, ul. Vavilova 26, Moscow, 119334, Russia.
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Zakharova
Koltzov Institute of Developmental Biology, Russian Academy of Sciences, ul. Vavilova 26, Moscow, 119334, Russia. v_melnikova@mail.ru.
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Melnikova
D000818:Animals; D002478:Cells, Cultured; D004298:Dopamine / Q000008:administration & dosage / Q000096:biosynthesis*; D004791:Enzyme Inhibitors; D005260:Female; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012333:RNA, Messenger / Q000378:metabolism; D017208:Rats, Wistar; D017448:Receptors, Dopamine D2 / Q000378:metabolism; D050637:Receptors, Dopamine D3 / Q000378:metabolism; D050641:Receptors, Dopamine D5 / Q000378:metabolism; D013601:T-Lymphocytes / Q000378:metabolism*; D060168:Thymocytes / Q000378:metabolism*; D013950:Thymus Gland / Q000254:growth & development* / Q000378:metabolism*; D019805:alpha-Methyltyrosine
C000607792:DRD2 protein, rat; C493595:Drd3 protein, rat; C493607:Drd5 protein, rat; D004791:Enzyme Inhibitors; D012333:RNA, Messenger; D017448:Receptors, Dopamine D2; D050637:Receptors, Dopamine D3; D050641:Receptors, Dopamine D5; D019805:alpha-Methyltyrosine; D004298:Dopamine