Colistin use and colistin resistance in bacteria from animals.
Colistin has been used in veterinary medicine for decades, mainly for the prevention and treatment of Enterobacteriaceae infections. However, data regarding colistin resistance in bacteria from animals and food of animal origin are relatively scarce, partly because there are methodological difficulties hampering the analysis of susceptibility to colistin. Most data regarding clinical isolates are related to enteropathogenic Escherichia coli and Salmonella. The resistance percentages are sometimes high for pathogenic strains, and the mcr-1 gene has been detected in pathogenic E. coli isolates from pigs, cattle and poultry in different countries. The prevalence of colistin resistance in Salmonella from healthy animals is usually low but depends on the proportion of intrinsically colistin-resistant serotypes. For indicator E. coli, the resistance levels are often very low, although higher levels have been observed in Asia. The mcr-1 gene has been detected in indicator E. coli from pigs, cattle, poultry and their products. Thus, there is an urgent need to re-assess the use of colistin in livestock throughout the world to ensure a global strategy for preserving this last-resort antimicrobial.
Ploufragan-Plouzané Laboratory, ANSES (French Agency for Food, Environmental and Occupational Health & Safety), Université Bretagne Loire, Ploufragan, France. Electronic address: isabelle.kempf@anses.fr.
Isabelle
I
Kempf
Ploufragan-Plouzané Laboratory, ANSES (French Agency for Food, Environmental and Occupational Health & Safety), Université Bretagne Loire, Ploufragan, France.
Eric
E
Jouy
Ploufragan-Plouzané Laboratory, ANSES (French Agency for Food, Environmental and Occupational Health & Safety), Université Bretagne Loire, Ploufragan, France.
Claire
C
Chauvin
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D002417:Cattle; D003091:Colistin / Q000494:pharmacology* / Q000627:therapeutic use*; D004755:Enterobacteriaceae / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D004756:Enterobacteriaceae Infections / Q000188:drug therapy / Q000382:microbiology / Q000662:veterinary*; D029968:Escherichia coli Proteins / Q000235:genetics; D014943:Global Health; D008461:Meat Products / Q000382:microbiology; D011200:Poultry; D015995:Prevalence; D013552:Swine
D000900:Anti-Bacterial Agents; D029968:Escherichia coli Proteins; C000614037:MCR-1 protein, E coli; D003091:Colistin
Animals; Colistin; Resistance; mcr-1