Differential Expression of Cardiac Troponin T and I in a Patient with Isolated Skeletal Muscular Sarcoidosis.
A 49-year-old female was referred to our hospital due to high serum creatine kinase (CK) (2,605 IU/L) and serum cardiac troponin T (cTnT) (0.342 ng/mL) levels. She had no other complaints and further examinations suggested no signs of cardiac disease. Additionally, the serum cardiac troponin I (cTnI) levels were normal. She reported having gradually felt difficulty in walking upstairs. A biopsy indicated skeletal muscle sarcoidosis with positive staining for cTnT. Steroid therapy immediately resolved her muscular symptoms with a normalization of the serum CK levels. Since the serum levels of cTnI were normal, the concomitant measurement of cTnT/cTnI might be useful to diagnose skeletal muscular disease biochemically in such cases.
Division of Cardiology, Cardiovascular and Aortic Center, Saiseikai Fukuoka General Hospital, Japan.
Hiroshi
H
Mannoji
Fumie
F
Hayashi
Toru
T
Kubota
Yoshihiko
Y
Ikeda
Hatsue
H
Ishibashi-Ueda
Seiya
S
Kato
Nobuhiro
N
Tahara
Takayoshi
T
Fukutomi
Takeshi
T
Yamada
Masanori
M
Okabe
Yusuke
Y
Yamamoto
D015415:Biomarkers / Q000097:blood; D003402:Creatine Kinase / Q000097:blood; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008875:Middle Aged; D018908:Muscle Weakness / Q000209:etiology; D018482:Muscle, Skeletal / Q000473:pathology; D012507:Sarcoidosis / Q000097:blood / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D019210:Troponin I / Q000097:blood; D020107:Troponin T / Q000097:blood
D015415:Biomarkers; D019210:Troponin I; D020107:Troponin T; D003402:Creatine Kinase