Osteoradionecrosis and intensity modulated radiation therapy: An overview.
Osteoradionecrosis (ORN) is an ongoing topic, especially about its definition, pathogenesis, staging system and management algorithm. But what about its real incidence in intensity modulated radiotherapy (IMRT) era? This paper discusses the mandible in radiation therapy planning as organ at risk and reviews the literature for evidence of radiation damage, discussing likely dose constraints and the use of IMRT to reduce radiation dose to this structure. PubMed search was performed.
Department of Radiotherapy, Policlinico Umberto I "Sapienza" University of Rome, Viale Regina Elena 326, 00161 Rome, Italy. Electronic address: fradefelice@hotmail.it.
Francesca
F
De Felice
Department of Radiotherapy, Policlinico Umberto I "Sapienza" University of Rome, Viale Regina Elena 326, 00161 Rome, Italy.
Daniela
D
Musio
Department of Radiotherapy, Policlinico Umberto I "Sapienza" University of Rome, Viale Regina Elena 326, 00161 Rome, Italy; Spencer-Lorillard Foundation, Viale Regina Elena 262, Rome, Italy.
Vincenzo
V
Tombolini
D006801:Humans; D008336:Mandibular Diseases / Q000209:etiology; D010025:Osteoradionecrosis; D011879:Radiotherapy Dosage; D050397:Radiotherapy, Intensity-Modulated / Q000009:adverse effects; D012307:Risk Factors
Dose; Head and neck cancer; IMRT; Mandible; Osteoradionecrosis; Toxicity