Deregulated miRNAs in human cervical cancer: functional importance and potential clinical use.
Cervical cancer (CC) is one of the most common malignancies affecting women worldwide. While the morbidity and mortality associated with CC are decreasing in western countries, they both remain high in developing countries. Unfortunately, many issues about molecular mechanisms of CC are not clear yet. miRNAs are a group of small noncoding RNAs that could post-transcriptionally modulate the expression of specific genes and participate in the initiation and progression of multiple diseases including CC. In the last decade, mounting evidences suggest an association between miRNAs and human papillomavirus infection, as well as variations in biologic behavior, treatment response and prognosis in CC. Herein, we highlight the latest findings in this area and the potential applications.
Department of Oncology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Jing
J
Li
Department of Obstetrics & Gynecology, the Affiliated Hospital of Jiangnan University & the Fourth People's Hospital of Wuxi, Wuxi, China.
Qiuli
Q
Liu
Division of Gynecological Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Leslie H
LH
Clark
Department of Obstetrics & Gynecology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Haifeng
H
Qiu
Division of Gynecological Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.|Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Victoria L
VL
Bae-Jump
Division of Gynecological Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.|Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Chunxiao
C
Zhou
D000818:Animals; D019008:Drug Resistance, Neoplasm; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D020022:Genetic Predisposition to Disease; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D030361:Papillomavirus Infections / Q000150:complications / Q000821:virology; D011379:Prognosis; D011836:Radiation Tolerance / Q000235:genetics; D002583:Uterine Cervical Neoplasms / Q000209:etiology* / Q000401:mortality / Q000473:pathology / Q000628:therapy
D035683:MicroRNAs
HPV infection; cervical cancer; miRNA; prognosis; susceptibility