Under Pressure: When a Transformed Environment Pushes Cells to Malignancy.
Mesenchymal stem/progenitor cells (MSPCs) have recently gained attention as key elements that contribute to different stages of oncogenesis, from predisposition to disease manifestation and evolution. In this issue of Cell Stem Cell, Zambetti et al. (2016) propose a mechanism by which mutated MSPCs transform hematopoietic cells into a malignant-prone state.
Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute and Department of Haematology, University of Cambridge, and National Health Service Blood and Transplant, Cambridge Biomedical Campus, CB2 0PT Cambridge, UK.
María
M
García-Fernández
Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute and Department of Haematology, University of Cambridge, and National Health Service Blood and Transplant, Cambridge Biomedical Campus, CB2 0PT Cambridge, UK. Electronic address: sm2116@medschl.cam.ac.uk.
Simón
S
Méndez-Ferrer
D063646:Carcinogenesis; D002478:Cells, Cultured; D006412:Hematopoietic Stem Cells; D006801:Humans; D059630:Mesenchymal Stem Cells