Radiation-induced lichen sclerosus of the vulva : First report in the medical literature.
A 67-year-old woman presented with a firm plaque in the perineal region, 16 months after diagnosis of a high-grade basaloid squamous cell carcinoma of the vagina and treatment by external beam radiation therapy and vaginal cuff brachytherapy. The differential diagnosis included radiation-induced morphea, radiation dermatitis, or, possibly, radiation-induced lichen sclerosus. Biopsy findings, including special staining, confirmed the diagnosis of radiation-induced lichen sclerosus. To our knowledge, this is the first report of radiation-induced lichen sclerosus of the vulvar region.
School of Medicine, University of Virginia Health System, Charlottesville, VA, USA.
Lisa R
LR
Edwards
Department of Dermatology, University of Virginia Health System, Charlottesville, VA, USA.
Emily D
ED
Privette
Department of Dermatology, University of Virginia Health System, Charlottesville, VA, USA.|Department of Pathology, University of Virginia Health System, 1215 Lee Street, Box 800214, 22908, Charlottesville, VA, USA.
James W
JW
Patterson
Department of Dermatology, Venereology and Dermatologic Surgery, Medical Institute of Ministry of Interior (MVR), General Skobelev blvd. 79, 1606, Sofia, Bulgaria. georgi_tchernev@yahoo.de.
Georgi
G
Tchernev
"Onkoderma"-Policlinic for Dermatology and Dermatologic Surgery, General Skobelev 26 blvd., Sofia, Bulgaria.|Department of Dermatology and Venereology, Medical University of Plovdiv, Plovdiv, Bulgaria.
Anastasiya Atanasova
AA
Chokoeva
Department of Dermatology and Allergology, Academic Teaching Hospital Dresden-Friedrichstadt, Friedrichstrasse 41, 01067, Dresden, Germany.
Uwe
U
Wollina
Dermatology, University of Rome "G.Marconi", Rome, Italy.
Torello
T
Lotti
Department of Dermatology, University of Virginia Health System, Charlottesville, VA, USA.
Barbara B
BB
Wilson
D000368:Aged; D001918:Brachytherapy; D002281:Carcinoma, Basosquamous / Q000532:radiotherapy*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D011855:Radiodermatitis / Q000175:diagnosis* / Q000473:pathology; D014625:Vaginal Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D014844:Vulva / Q000473:pathology; D007724:Vulvar Lichen Sclerosus / Q000175:diagnosis* / Q000473:pathology
BCC; Dermatatis; Genital area; Lichenoid; Radiation; Surgery