Classification of Kidney Transplant Recipients Using a Combination of Estimated GFR and Albuminuria Reflects Risk.
BACKGROUND
The 2012 Kidney Dialysis Initiative Global Outcomes chronic kidney disease (CKD) classification scheme subdivides stage 3 CKD and incorporates the urinary albumin-to-creatinine ratio (ACR). The aim of this study was to evaluate whether the novel scheme provides graded risk in kidney transplant recipients (KTRs).


METHODS
Prevalent KTRs with available laboratory data were included. The primary outcome was a composite of doubling of serum creatinine, graft failure, or death. Patients were stratified using the CKD-Epidemiolgic Collaboration equation, and ACR and the event rate per 1000 patient-years in each CKD category were calculated.


RESULTS
There were 269 KTRs with a mean follow-up of 4.5 ± 2.0 years. There was a graded increase in outcomes with increasing ACR and decreasing estimated glomerular filtration rate (eGFR). For the primary outcome, the event rate was 15.3 (95% confidence interval, 4.2-39.2) per 1000 patient-years for those with an eGFR greater than 60 mL/min per 1.73 m2and an ACR less than 30 mg/g, whereas it was 375 (95% confidence interval, 193.8-655.1) for those with an eGFR less than 30 mL/min per 1.73 m2and an ACR greater than 300 mg/g.


CONCLUSIONS
The novel Kidney Dialysis Initiative Global Outcomes classification scheme provides graded risk for important clinical events in KTRs. This information can be used to identify high-risk patients and to tailor follow-up and management strategies aimed at improving outcomes.
Division of Nephrology, Department of Medicine, Queen's University, Kingston, Ontario, Canada.
Christine A
CA
White
Division of Nephrology, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada.; Kidney Research Centre, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
Ayub
A
Akbari
Division of Nephrology, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
Hari
H
Talreja
Division of Nephrology, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
Neha
N
Lalani
Division of Nephrology, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada.; Kidney Research Centre, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
Greg A
GA
Knoll