Cortisol and ACTH levels in drug-naive adolescents with first-episode early onset schizophrenia.
The aim of this study was to investigate serum levels of cortisol and adrenocorticotropic hormone in adolescents with first-episode early onset schizophrenia. A total of 23 adolescent patients, who did not receive prior therapy and who were diagnosed with psychosis according to DSM-IV, were included. Kiddie-Schedule for Affective Disorders and Schizophrenia-Present and Lifetime Version, Positive and Negative Symptom Scale, and Clinical Global Impression Scale were conducted with the participants. No significant differences were found between the patients and the control subjects in serum cortisol and adrenocorticotropic hormone levels (P > .05). Our study's findings do not support the hypothesis of increased hypothalamic-pituitary-adrenal axis activity in first-episode early onset schizophrenia.
Department of Child Psychiatry, Medical School, Dicle University, Diyarbakır, Turkey.
Şeref
Ş
Şimşek
Department of Child Psychiatry, Medical School, Yüzüncü Yıl University, Van, Turkey.
Salih
S
Gençoğlan
Department of Child Psychiatry, Medical School, Dicle University, Diyarbakır, Turkey.
Tuğba
T
Yüksel
Department of Child Psychiatry, Medical School, Dicle University, Diyarbakır, Turkey.
Hüseyin
H
Aktaş
D000293:Adolescent; D000324:Adrenocorticotropic Hormone / Q000097:blood*; D002648:Child; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology; D008297:Male; D010913:Pituitary-Adrenal System / Q000503:physiopathology; D012559:Schizophrenia / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology
D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone
HPA axis; cortisol; early onset schizophrenia; first-episode psychosis; psychosis