Novel Isochroman Dimers from Stachybotrys sp. PH30583: Fermentation, Isolation, Structural Elucidation and Biological Activities.
The rare anishidiol and five new isochromans, including three novel dimers with unprecedented skeletons, were isolated fromStachybotryssp. PH30583. Their structures were determined by spectral analyses. The bioactivities of these compounds were also investigated. The dimers (6-10) inhibited acetylcholinesterase at 50 µM, but the monomers did not. To investigate the biogenesis of the novel dimers, a time-course investigation of metabolite production was undertaken.
School of Chemical Science and Technology, Yunnan University, Kunming, China.
Wei
W
Li
School of Chemical Science and Technology, Yunnan University, Kunming, China.
Ya-Bin
YB
Yang
School of Chemical Science and Technology, Yunnan University, Kunming, China.
Xue-Qiong
XQ
Yang
School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, China.
Hui-Ding
HD
Xie
School of Chemical Science and Technology, Yunnan University, Kunming, China.
Zhi-Hui
ZH
Shao
School of Chemical Science and Technology, Yunnan University, Kunming, China.
Hao
H
Zhou
Yunnan Institute of Microbiology, Yunnan University, Kunming, China.
Cui-Ping
CP
Miao
Yunnan Institute of Microbiology, Yunnan University, Kunming, China.
Li-Xing
LX
Zhao
School of Chemical Science and Technology, Yunnan University, Kunming, China.
Zhong-Tao
ZT
Ding
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002839:Chromans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D005285:Fermentation; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013191:Stachybotrys / Q000737:chemistry*
D000900:Anti-Bacterial Agents; D002800:Cholinesterase Inhibitors; D002839:Chromans