Sphingosine-1-phosphate receptor therapies: Advances in clinical trials for CNS-related diseases.
The family of sphingosine-1-phosphate receptors (S1PRs) are G protein-coupled and comprise of five subtypes, S1P1-S1P5. These receptors are activated by the sphingolipid ligand, S1P, which is produced from the phosphorylation of sphingosine by sphingosine kinases. The activation of S1PRs modulates a host of cellular processes such as cell proliferation, migration and survival. These receptors are targeted by the drug fingolimod, a first in class oral therapy for multiple sclerosis. Importantly, S1PRs have also been implicated, in cellular experiments, pre-clinical studies and clinical trials in a range of other neurodegenerative diseases, neurological disorders and psychiatric illnesses, where S1PR drugs are proving beneficial. Overall, studies now highlight the importance of S1PRs as targets for modulating a variety of debilitating brain-related diseases. Here, we review the role of S1PRs in these illnesses. This article is part of the Special Issue entitled 'Lipid Sensing G Protein-Coupled Receptors in the CNS'.
Drug Development, School of Medicine, Trinity College Dublin, Ireland.
Sinead
S
O'Sullivan
Drug Development, School of Medicine, Trinity College Dublin, Ireland. Electronic address: devk@tcd.ie.
Kumlesh K
KK
Dev
D000818:Animals; D002491:Central Nervous System Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D002493:Central Nervous System Diseases / Q000188:drug therapy* / Q000378:metabolism*; D002986:Clinical Trials as Topic; D006801:Humans; D008246:Lysophospholipids / Q000378:metabolism; D049349:Receptors, Lysosphingolipid / Q000378:metabolism*; D013110:Sphingosine / Q000031:analogs & derivatives / Q000378:metabolism
D002491:Central Nervous System Agents; D008246:Lysophospholipids; D049349:Receptors, Lysosphingolipid; C060506:sphingosine 1-phosphate; D013110:Sphingosine
Ceralifimod (PubChem CID: 11502996); Clinical trials; FTY720; Fingolimod; Fingolimod (PubChem CID: 107970); Ozanimod (PubChem CID: 52938427); Ponesimod (PubChem CID: 11363176); Siponimod (PubChem CID: 44599207); Sphingosine1-phosphate receptors (S1PRs)