ROS homeostasis and metabolism: a critical liaison for cancer therapy.
Evidence indicates that hypoxia and oxidative stress can control metabolic reprogramming of cancer cells and other cells in tumor microenvironments and that the reprogrammed metabolic pathways in cancer tissue can also alter the redox balance. Thus, important steps toward developing novel cancer therapy approaches would be to identify and modulate critical biochemical nodes that are deregulated in cancer metabolism and determine if the therapeutic efficiency can be influenced by changes in redox homeostasis in cancer tissues. In this review, we will explore the molecular mechanisms responsible for the metabolic reprogramming of tumor microenvironments, the functional modulation of which may disrupt the effects of or may be disrupted by redox homeostasis modulating cancer therapy.
Cancer Control Team, Gachon University Gil Medical Center, Incheon, Republic of Korea.
Jongdoo
J
Kim
Department of Biochemistry, School of Medicine, Gachon University, Incheon, Republic of Korea.|Department of Health Sciences and Technology, Gachon Advanced Institute for Health Science and Technology, Gachon University, Incheon, Republic of Korea.
Jaehong
J
Kim
College of Pharmacy, CMRI, Research Institute of Pharmaceutical Sciences, Daegu, Republic of Korea.
Jong-Sup
JS
Bae
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D005947:Glucose / Q000378:metabolism; D006706:Homeostasis / Q000187:drug effects; D006801:Humans; D053858:Metabolic Networks and Pathways / Q000187:drug effects; D058990:Molecular Targeted Therapy / Q000379:methods; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism*; D010084:Oxidation-Reduction / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects; D017382:Reactive Oxygen Species / Q000378:metabolism*; D059016:Tumor Microenvironment / Q000187:drug effects
D000970:Antineoplastic Agents; D017382:Reactive Oxygen Species; D005947:Glucose