Serum monocyte fraction of white blood cells is increased in patients with high Gleason score prostate cancer.
Systemic inflammation and immune responses are reported to be associated with progressive prostate cancer. In this study, we explored which among the fractions of white blood cell (WBC) and C-reactive protein (CRP) level were associated with high Gleason score prostate cancer. Prostate needle biopsy was performed in 966 men with suspicion of prostate cancer. We assessed age, serum prostate-specific antigen (PSA), prostate volume, WBC count, fractions of WBCs (neutrophils, lymphocytes, monocytes, basophils, and eosinophils), and CRP level before biopsy for associations with biopsy findings. Among all men, 553 (57.2%) were positive for prostate cancer including 421 with high Gleason score cancer (Gleason score ≥7). Age, PSA, PSA density (PSAD), serum monocyte fraction of WBC, monocyte-to-lymphocyte ratio (MLR), and CRP were significantly associated with high Gleason score cancer (p<0.01). Multivariate analysis showed that age, PSA, PSAD, and serum monocyte fraction were significantly associated with high Gleason score prostate cancer (p <0.01). In 571 patients with PSA of <10 ng/ml, age, PSA, PSAD, serum WBC count, neutrophil fraction, monocyte fraction, and MLR were significantly associated with high Gleason score prostate cancer (p<0.05). Multivariate analysis showed that age, PSAD, and serum monocyte fraction were significantly associated with high Gleason score prostate cancer (p<0.01). The monocyte fraction of WBCs was increased in patients with high Gleason score prostate cancer, suggesting an interaction of monocytes with the progression of prostate cancer.
Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan.
Takuji
T
Hayashi
Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan.
Kazutoshi
K
Fujita
Department of Urology, Osaka General Medical Center, Osaka, Japan.
Go
G
Tanigawa
Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan.
Atsunari
A
Kawashima
Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan.
Akira
A
Nagahara
Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan.
Takeshi
T
Ujike
Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan.
Motohide
M
Uemura
Department of Urology, Osaka General Medical Center, Osaka, Japan.
Tetsuya
T
Takao
Department of Urology, Osaka General Medical Center, Osaka, Japan.
Seiji
S
Yamaguchi
Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan.
Norio
N
Nonomura
D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001707:Biopsy, Needle; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000378:metabolism*; D060787:Neoplasm Grading; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000097:blood / Q000378:metabolism / Q000473:pathology*
D017430:Prostate-Specific Antigen
Gleason score; biopsy; monocyte; prostate cancer; serum