The relationship between recognition memory for emotion-laden words and white matter microstructure in normal older individuals.
Functional neuroimaging studies have shown age-related differences in brain activation and connectivity patterns for emotional memory. Previous studies with middle-aged and older adults have reported associations between episodic memory and white matter (WM) microstructure obtained from diffusion tensor imaging, but such studies on emotional memory remain few. To our knowledge, this is the first study to explore associations between WM microstructure as measured by fractional anisotropy (FA) and recognition memory for intentionally encoded positive, negative, and emotionally neutral words using tract-based spatial statistics applied to diffusion tensor imaging images in an elderly sample (44 cognitively intact adults aged 50-79 years). The use of tract-based spatial statistics enables the identification of WM tracts important to emotional memory without a priori assumptions required for region-of-interest approaches that have been used in previous work. The behavioral analyses showed a positivity bias, that is, a preference for positive words, in recognition memory. No statistically significant associations emerged between FA and memory for negative or neutral words. Controlling for age and memory performance for negative and neutral words, recognition memory for positive words was negatively associated with FA in several projection, association, and commissural tracts in the left hemisphere. This likely reflects the complex interplay between the mnemonic positivity bias, structural WM integrity, and functional brain compensatory mechanisms in older age. Also, the unexpected directionality of the results indicates that the WM microstructural correlates of emotional memory show unique characteristics in normal older individuals.
aDepartment of Psychology, Abo Akademi University, Åbo bCentre for Cognitive Neuroscience cTurku Brain and Mind Center dTurku PET Centre, University of Turku eDepartment of Medical Physics fDivision of Clinical Neurosciences, Turku University Hospital, Turku gBioMediTech, Tampere University of Technology hDepartment of Radiology, Tampere University Hospital iDepartment of Radiology, University of Tampere, Tampere, Finland.
Carina
C
Saarela
Mira
M
Karrasch
Tero
T
Ilvesmäki
Riitta
R
Parkkola
Juha O
JO
Rinne
Matti
M
Laine
D000368:Aged; D000375:Aging; D016880:Anisotropy; D056324:Diffusion Tensor Imaging; D004644:Emotions / Q000502:physiology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D009434:Neural Pathways / Q000000981:diagnostic imaging / Q000502:physiology*; D021641:Recognition, Psychology / Q000502:physiology*; D014706:Verbal Learning / Q000502:physiology; D014825:Vocabulary; D066127:White Matter / Q000000981:diagnostic imaging / Q000502:physiology*