Miniaturized and Wireless Optical Neurotransmitter Sensor for Real-Time Monitoring of Dopamine in the Brain.
Real-time monitoring of extracellular neurotransmitter concentration offers great benefits for diagnosis and treatment of neurological disorders and diseases. This paper presents the study design and results of a miniaturized and wireless optical neurotransmitter sensor (MWONS) for real-time monitoring of brain dopamine concentration. MWONS is based on fluorescent sensing principles and comprises a microspectrometer unit, a microcontroller for data acquisition, and a Bluetooth wireless network for real-time monitoring. MWONS has a custom-designed application software that controls the operation parameters for excitation light sources, data acquisition, and signal processing. MWONS successfully demonstrated a measurement capability with a limit of detection down to a 100 nanomole dopamine concentration, and high selectivity to ascorbic acid (90:1) and uric acid (36:1).
Center for Materials Research, Norfolk State University, Norfolk, VA 23504, USA. m.kim@spartans.nsu.edu.
Min H
MH
Kim
Center for Materials Research, Norfolk State University, Norfolk, VA 23504, USA. hyoon@nsu.edu.|Neural Engineering and Nano Electronics Laboratory, Department of Engineering, Norfolk State University, Norfolk, VA 23504, USA. hyoon@nsu.edu.
Hargsoon
H
Yoon
NASA Langley Research Center, Hampton, VA 23681, USA. sang.h.choi@nasa.gov.
Sang H
SH
Choi
Department of Chemical and Biological Engineering, Gachon University, Seongnam 13120, Korea. zhaofei0911@gmail.com.
Fei
F
Zhao
Department of Chemical and Biological Engineering, Gachon University, Seongnam 13120, Korea. jongkim@gachon.ac.kr.
Jongsung
J
Kim
Center for Materials Research, Norfolk State University, Norfolk, VA 23504, USA. ksong@nsu.edu.|Neural Engineering and Nano Electronics Laboratory, Department of Engineering, Norfolk State University, Norfolk, VA 23504, USA. ksong@nsu.edu.
Kyo D
KD
Song
Department of Neurosurgery, Gachon University of Medicine and Science, Incheon 21936, Korea. uhn@gachon.ac.kr.
Uhn
U
Lee
D000465:Algorithms; D015374:Biosensing Techniques / Q000379:methods*; D001921:Brain / Q000378:metabolism*; D004298:Dopamine / Q000032:analysis*; D006801:Humans; D018377:Neurotransmitter Agents / Q000032:analysis*; D012815:Signal Processing, Computer-Assisted; D059015:Wireless Technology
D018377:Neurotransmitter Agents; D004298:Dopamine
dopamine; fluorescence; microspectrometer; optical sensing; wireless