Clinical impact of preoperative albumin to globulin ratio in gastric cancer patients with curative intent.
BACKGROUND
Low albumin-to-globulin ratio (AGR) is associated with increased cancer mortality in patients with various cancers. However, there are no reports regarding the relation between pretreatment AGR and clinicopathological data, including oncological outcomes, in gastric cancer (GC) patients with curative intent.


METHODS
Clinicopathological findings including preoperative laboratory data from 384 curative GC patients were assessed as indicators of early recurrence and poor prognosis in this retrospective study. AGR was calculated as albumin/(total protein - albumin)].


RESULTS
Several pathological categories related to tumor progression were associated with low AGR levels. Among preoperative serum markers, AGR was an independent predictor of early recurrence in curative GC patients. By multivariate analysis using both preoperative serum markers and postoperative clinicopathological categories, 2 pathological factors, lymph node metastasis and serosal invasion, and low AGR were independently associated with early recurrence. Furthermore, GC patients with low AGR showed significantly poor disease-free survival in the lymph node metastasis and serosal invasion groups.


CONCLUSIONS
AGR was a novel independent predictor of early recurrence in curative GC patients.
Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Graduate School of Medicine, Mie University, Mie, Japan. Electronic address: ytoi0725@clin.medic.mie-u.ac.jp.
Yuji
Y
Toiyama
Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Graduate School of Medicine, Mie University, Mie, Japan.
Hiromi
H
Yasuda
Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Graduate School of Medicine, Mie University, Mie, Japan.
Masaki
M
Ohi
Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Graduate School of Medicine, Mie University, Mie, Japan.
Shigeyuki
S
Yoshiyama
Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Graduate School of Medicine, Mie University, Mie, Japan.
Toshimitsu
T
Araki
Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Graduate School of Medicine, Mie University, Mie, Japan.
Koji
K
Tanaka
Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Graduate School of Medicine, Mie University, Mie, Japan.
Yasuhiro
Y
Inoue
Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Graduate School of Medicine, Mie University, Mie, Japan.
Yasuhiko
Y
Mohri
Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Graduate School of Medicine, Mie University, Mie, Japan.
Masato
M
Kusunoki
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D057234:Preoperative Period; D012189:Retrospective Studies; D012307:Risk Factors; D012709:Serum Albumin / Q000378:metabolism*; D012712:Serum Globulins / Q000378:metabolism*; D013274:Stomach Neoplasms / Q000097:blood* / Q000401:mortality / Q000473:pathology*; D015996:Survival Rate
D012709:Serum Albumin; D012712:Serum Globulins
Albumin to globulin ratio; Gastric cancer; Recurrence