Developing a new algorithm for first and second trimester preeclampsia screening in twin pregnancies.
OBJECTIVE
Construct a new preeclampsia predicting algorithm in twins.


METHODS
Twins sampled at 10-13 and 16-20 gestational weeks and their marker values were log transformed into multiples of the gestation-specific medians (MoMs) for singletons and entered into a new logistic regression model with/without prior risk factors.


RESULTS
The cohort included 9 PE (18 samples) and 96 unaffected cases (175 samples) twin pregnant women. The algorithm constructed of PlGF, PAPP-A, PP13, Doppler UTPI, and MAP with prior risk factors generated an area under the curve of 0.918, 75% detection rate for 10% false-positive rate.


CONCLUSIONS
The algorithm effectively forecasted twin risk to develop PE.
a Institute of Ultrasound, Department of Obstetrics and Gynecology , Assaf Harofeh Medical Centre, Affiliated with the Sackler School of Medicine , Tel-Aviv , Israel.|b Tel-Aviv University , Tel-Aviv , Israel.
Ron
R
Maymon
c Hy Laboratories , Rehovot , Israel.
Alla
A
Trahtenherts
a Institute of Ultrasound, Department of Obstetrics and Gynecology , Assaf Harofeh Medical Centre, Affiliated with the Sackler School of Medicine , Tel-Aviv , Israel.|b Tel-Aviv University , Tel-Aviv , Israel.
Ran
R
Svirsky
a Institute of Ultrasound, Department of Obstetrics and Gynecology , Assaf Harofeh Medical Centre, Affiliated with the Sackler School of Medicine , Tel-Aviv , Israel.|b Tel-Aviv University , Tel-Aviv , Israel.
Yaakov
Y
Melcer
c Hy Laboratories , Rehovot , Israel.
Liora
L
Madar-Shapiro
a Institute of Ultrasound, Department of Obstetrics and Gynecology , Assaf Harofeh Medical Centre, Affiliated with the Sackler School of Medicine , Tel-Aviv , Israel.|b Tel-Aviv University , Tel-Aviv , Israel.
Esther
E
Klog
c Hy Laboratories , Rehovot , Israel.
Hamutal
H
Meiri
b Tel-Aviv University , Tel-Aviv , Israel.
Howard
H
Cuckle
D000328:Adult; D000465:Algorithms; D015415:Biomarkers / Q000097:blood; D005260:Female; D037161:Galectins / Q000097:blood; D005865:Gestational Age; D006801:Humans; D000072483:Placenta Growth Factor / Q000097:blood; D011225:Pre-Eclampsia / Q000097:blood / Q000175:diagnosis* / Q000000981:diagnostic imaging; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000097:blood; D011261:Pregnancy Trimester, First; D011262:Pregnancy Trimester, Second; D059285:Pregnancy, Twin; D011266:Pregnancy-Associated Plasma Protein-A / Q000378:metabolism; D018608:Ultrasonography, Doppler; D016216:Ultrasonography, Prenatal
D015415:Biomarkers; D037161:Galectins; C038195:LGALS13 protein, human; D011257:Pregnancy Proteins; D000072483:Placenta Growth Factor; D011266:Pregnancy-Associated Plasma Protein-A
Doppler UTPI; MAP; PAPP-A; PP13; PlGF