Ameliorative potential of α-tocopherol against flubendiamide and copper-induced testicular-insult in Wistar rats.
Study was undertaken to evaluate ameliorative potential of α-tocopherol against copper sulphate and flubendiamide alone and in combination-induced toxicity in rats following 90 days exposure. Absolute and relative organ weights did not differ between treatments groups. Increase of LPO in copper and flubendiamide intoxicated rats but modest increase in copper + flubendiamide group. GSH and activities of SOD, GPx and GST showed moderate decrease in intoxicated groups. Reduced CAT activity in alone exposed groups was observed. ACP, ALP and SDH remain unaltered. Increase in LDH, γ-GT, abnormal sperm and reduced 17β-HSD, percent live and HOST +ve sperms and testosterone level was observed in all three exposed groups. Xenobiotics alone and in combination exhibited degenerative germinal epithelium, necrotic germ cells, loss of spermatozoa and spermatids. Treatment with α-tocopherol, reparative potential was observed as values of most of the parameters including testicular histoarchitecture were restored.
Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, U.P. Pt. Deen Dayal Upadhyay Pashu Chikitsa Vigyan Vishwavidyalaya Evam Go-Anusandhan Sansthan (DUVASU), Mathura, 281001, India. Electronic address: rajesh_mandil@rediffmail.com.
Rajesh
R
Mandil
Central Institute for Research on Goat (CIRG), Makhdoom, Farah, Mathura, Uttar Pradesh, 281122, India.
Anu
A
Rahal
Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, U.P. Pt. Deen Dayal Upadhyay Pashu Chikitsa Vigyan Vishwavidyalaya Evam Go-Anusandhan Sansthan (DUVASU), Mathura, 281001, India.
Atul
A
Prakash
Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, U.P. Pt. Deen Dayal Upadhyay Pashu Chikitsa Vigyan Vishwavidyalaya Evam Go-Anusandhan Sansthan (DUVASU), Mathura, 281001, India.
Satish K
SK
Garg
Department of Veterinary Pathology, College of Veterinary Science and Animal Husbandry, U.P. Pt. Deen Dayal Upadhyay Pashu Chikitsa Vigyan Vishwavidyalaya Evam Go-Anusandhan Sansthan (DUVASU), Mathura, 281001, India.
Neeraj K
NK
Gangwar
Department of Veterinary Physiology, College of Veterinary Science and Animal Husbandry, U.P. Pt. Deen Dayal Upadhyay Pashu Chikitsa Vigyan Vishwavidyalaya Evam Go-Anusandhan Sansthan (DUVASU), Mathura, 281001, India.
Dilip K
DK
Swain
D000284:Administration, Oral; D000818:Animals; D001549:Benzamides / Q000633:toxicity*; D015415:Biomarkers / Q000378:metabolism; D003300:Copper / Q000633:toxicity*; D004487:Edema / Q000473:pathology; D008297:Male; D009929:Organ Size / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects; D017208:Rats, Wistar; D012661:Semen / Q000378:metabolism; D012671:Seminiferous Tubules / Q000187:drug effects / Q000378:metabolism; D013450:Sulfones / Q000633:toxicity*; D013737:Testis / Q000187:drug effects / Q000201:enzymology / Q000473:pathology*; D013739:Testosterone / Q000378:metabolism; D024502:alpha-Tocopherol / Q000008:administration & dosage / Q000494:pharmacology*; D005466:Fluorocarbons; D010797:Phthalimides
D001549:Benzamides; D015415:Biomarkers; D003300:Copper; D013450:Sulfones; D013739:Testosterone; D024502:alpha-Tocopherol; C508762:flubendiamide; D005466:Fluorocarbons; D010797:Phthalimides
Copper; Flubendiamide; Histopathology; Oxidative stress; Testes; Testosterone