Remineralizing Potential of a Low Fluoride Toothpaste with Sodium Trimetaphosphate: An in situ Study.
To evaluate the effect of a low-fluoride (F) toothpaste supplemented with sodium trimetaphosphate (TMP) on enamel remineralization in situ.



Bovine enamel blocks were selected on the basis of their surface hardness (SH) after caries-like lesions had been induced, and randomly divided into 4 treatment groups, according to the toothpastes used: without F or TMP (placebo); 500 ppm F; 500 ppm F plus 1% TMP; and 1,100 ppm F. The study design was blinded and crossover and performed in 4 phases of 3 days each. Eleven subjects used palatal appliances containing 4 bovine enamel blocks which were treated 3 times per day during 1 min each time, with natural slurries of saliva and toothpaste formed in the oral cavity during toothbrushing. After each phase, the percentages of surface (%SHR) and subsurface hardness recovery (%ΔKHNR) were calculated. F, calcium (Ca), and phosphorus (Pi) contents in enamel were also determined. Data were analyzed by 1-way, repeated-measures ANOVA, followed by the Student-Newman-Keuls test (p < 0.05).



Toothpaste with 500 ppm F + TMP and 1,100 ppm F showed similar %SHR and %ΔKHNR as well as enamel F, Ca, and Pi concentrations.



The addition of TMP to a low-fluoride toothpaste promoted a similar remineralizing capacity to that of a standard (1,100 ppm F) toothpaste in situ.
Department of Pediatric Dentistry and Public Health, Araçatuba Dental School, UNESP - Universidade Estadual Paulista, Araçatuba, Brazil.
Eliana M
EM
Takeshita
Marcelle
M
Danelon
Luciene P
LP
Castro
Robson F
RF
Cunha
Alberto C B
AC
Delbem
D000704:Analysis of Variance; D000818:Animals; D002118:Calcium / Q000032:analysis; D002417:Cattle; D018592:Cross-Over Studies; D003731:Dental Caries / Q000517:prevention & control*; D003743:Dental Enamel / Q000187:drug effects*; D004311:Double-Blind Method; D005459:Fluorides / Q000032:analysis; D006244:Hardness / Q000187:drug effects; D006801:Humans; D011122:Polyphosphates / Q000494:pharmacology / Q000627:therapeutic use; D011897:Random Allocation; D012463:Saliva; D012969:Sodium Fluoride / Q000494:pharmacology* / Q000627:therapeutic use; D014089:Tooth Remineralization / Q000379:methods*; D014099:Toothbrushing; D014100:Toothpastes / Q000494:pharmacology* / Q000627:therapeutic use
D011122:Polyphosphates; D014100:Toothpastes; D012969:Sodium Fluoride; C009293:trimetaphosphoric acid; D005459:Fluorides; D002118:Calcium