Synthesis of pyrrolo[2,1-f][1,2,4]triazin-4(3H)-ones: Rearrangement of pyrrolo[1,2-d][1,3,4]oxadiazines and regioselective intramolecular cyclization of 1,2-biscarbamoyl-substituted 1H-pyrroles.
Pyrrolo[2,1-f][1,2,4]triazin-4(3H)-ones12have been easily prepared via nucleophile-induced rearrangement of pyrrolooxadiazines11and regioselective intramolecular cyclization of 1,2-biscarbamoyl-substituted 1H-pyrroles10. In this work, we demonstrated that the described synthetic approaches can be considered to be more facile and practical than previously reported procedures.
Research Center for Medicinal Chemistry, Korea Research Institute of Chemical Technology (KRICT), 141 Gajeong-ro, Yuseong-gu, Daejeon 305-600, Korea; Department of Chemistry, Sogang University, 35 Baekbeom-ro, Mapo-gu, Seoul 121-742, Korea.
Kkonnip
K
Son
Research Center for Medicinal Chemistry, Korea Research Institute of Chemical Technology (KRICT), 141 Gajeong-ro, Yuseong-gu, Daejeon 305-600, Korea.
Seong Jun
SJ
Park
intramolecular cyclization; pyrrolooxadiazines; pyrrolotriazinone; rearrangement