The association, clinicopathological significance, and diagnostic value ofCDH1promoter methylation in head and neck squamous cell carcinoma: a meta-analysis of 23 studies.
Epithelial cadherin (encoded by theCDH1gene) is a tumor suppressor glycoprotein that plays a role in the invasion and metastasis of human cancers. As previous studies regarding the association betweenCDH1promoter methylation and head and neck squamous cell carcinoma (HNSCC) have yielded inconsistent conclusions, a meta-analysis was performed. A systematic literature review was undertaken from four databases: PubMed, Embase, Google Scholar, and Web of Science. Finally, a total of 23 studies (including 1,727 cases of HNSCC and 555 normal controls) were included in the present study. Our results showed that the frequency ofCDH1promoter methylation in HNSCC was statistically greater than in controls (odds ratio [OR] =5.94, 95% confidence interval [CI]: 3.36-10.51,P<0.001). In reported cases of HNSCC,CDH1promoter methylation was statistically associated with tumor stage (OR =0.46, 95% CI: 0.27-0.78,P=0.004) and a history of alcohol consumption (OR =6.04, 95% CI: 2.41-15.14,P<0.001). Moreover, the sensitivity, specificity, and area under the curve of the summary receiver operator characteristic for the included studies were 0.50 (95% CI: 0.4-0.61), 0.89 (95% CI: 0.79-0.95), and 0.74 (95% CI: 0.70-0.78), respectively. In conclusion, our meta-analyses indicated thatCDH1promoter methylation was associated with HNSCC risk, and may be utilized as a valuable diagnostic biomarker for HNSCC.
Department of Otorhinolaryngology-Head and Neck Surgery, Lihuili Hospital, Ningbo University.
Zhisen
Z
Shen
Department of Otorhinolaryngology-Head and Neck Surgery, Lihuili Hospital, Ningbo University; Department of Biochemistry and Molecular Biology, Medical School of Ningbo University.
Chongchang
C
Zhou
Department of Biochemistry and Molecular Biology, Medical School of Ningbo University.
Jinyun
J
Li
Department of Otorhinolaryngology-Head and Neck Surgery, Lihuili Hospital, Ningbo University.
Hongxia
H
Deng
Department of Otorhinolaryngology-Head and Neck Surgery, Lihuili Hospital, Ningbo University.
Qun
Q
Li
Department of Otorhinolaryngology-Head and Neck Surgery, Ningbo Yinzhou People's Hospital, Ningbo, Zhejiang, People's Republic of China.
Jian
J
Wang
CDH1; HNSCC; diagnosis; head and neck squamous cell carcinoma; methylation