Risk factors and outcomes of macrosomia in China: a multicentric survey based on birth data.
OBJECTIVE
To investigate the risk factors and outcomes of macrosomia in China.


METHODS
This was a multicenter, retrospective cohort study conducted in China. 178 709 singletons weighing ≥ 2500 g with gestational ages of 37-44 weeks were included. We compared the macrosomia group (with birth weight (BW) ≥ 4000 g) with the nornosomic control group (weighting 2500-3999 g).


RESULTS
The total prevalence of macrosomia was 8.70%. The strongest risk factors correlated with macrosomia were maternal obesity and gestational diabetes mellitus (GDM). The risks of obstetric and neonatal complications increased when infants had a BW of ≥4000 g.


CONCLUSIONS
Obesity and GDM are the most prominent risk factors for macrosomia, and macrosomia is associated with adverse maternal and neonate outcomes. Therefore, monitoring and controlling maternal weight and blood glucose could decrease the prevalence of macrosomia or improve its poor outcomes.
a Department of Neonatology , The First Affiliated Hospital of Wenzhou Medical University , Wenzhou , China.
Dan
D
Wang
b Taizhou Municipal Hospital , Taizhou , China.
Yan
Y
Hong
c Children's Hospital of Fudan University , Shanghai , China.
Li
L
Zhu
d Shanghai Jiading Maternal and Child Care Hospital , Shanghai , China.
Xiaoli
X
Wang
e Ningbo Women and Children's Hospital , Ningbo , China , and.
Qin
Q
Lv
f Jiangsu Wuxi Maternal and Child Health Care Hospital , Wuxi , China.
Qin
Q
Zhou
a Department of Neonatology , The First Affiliated Hospital of Wenzhou Medical University , Wenzhou , China.
Miaohua
M
Ruan
c Children's Hospital of Fudan University , Shanghai , China.
Chao
C
Chen
D000367:Age Factors; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D036861:Delivery, Obstetric / Q000706:statistics & numerical data*; D016640:Diabetes, Gestational; D005260:Female; D005320:Fetal Macrosomia / Q000453:epidemiology* / Q000209:etiology; D005865:Gestational Age; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009765:Obesity / Q000150:complications; D011247:Pregnancy; D011248:Pregnancy Complications; D011256:Pregnancy Outcome; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors
Macrosomia; multicentric survey; outcome; prevalence; risk factor