Neural circuits for pain: Recent advances and current views.
The mammalian nervous system encodes many different forms of pain, from those that arise as a result of short-term low-grade interactions with noxious thermal, chemical, or mechanical sources to more serious forms of pain induced by trauma and disease. In this Review, we highlight recent advances in our understanding of the neural circuits that encode these types of pain. Promising therapeutic strategies based on recent advances are also highlighted.
Departments of Neurobiology and Otolaryngology, University of Pittsburgh School of Medicine, 3501 Fifth Avenue, BST3, Pittsburgh, PA 15213, USA.|Pittsburgh Center for Pain Research, University of Pittsburgh School of Medicine, 200 Lothrop Street, Pittsburgh, PA 15213, USA.
Cedric
C
Peirs
Departments of Neurobiology and Otolaryngology, University of Pittsburgh School of Medicine, 3501 Fifth Avenue, BST3, Pittsburgh, PA 15213, USA. rpseal@pitt.edu.|Pittsburgh Center for Pain Research, University of Pittsburgh School of Medicine, 200 Lothrop Street, Pittsburgh, PA 15213, USA.
Rebecca P
RP
Seal
D000818:Animals; D001921:Brain / Q000503:physiopathology; D006801:Humans; D006930:Hyperalgesia / Q000503:physiopathology; D009434:Neural Pathways / Q000033:anatomy & histology / Q000502:physiology*; D009619:Nociceptors / Q000502:physiology*; D010146:Pain / Q000188:drug therapy / Q000503:physiopathology*; D059408:Pain Management / Q000379:methods; D017729:Presynaptic Terminals / Q000502:physiology; D013116:Spinal Cord / Q000033:anatomy & histology / Q000503:physiopathology