Bifunctional Carbon-Dot-WS2Nanorods for Photothermal Therapy and Cell Imaging.
Multifunctional nanoparticles have attracted significant interest as biomedical vehicles, combining diagnostic, imaging, and therapeutic properties. We describe herein the construction of new nanoparticle conjugates comprising WS2nanorods (NRs) coupled to fluorescent carbon dots (C-dots). We show that the WS2-C-dot hybrids integrate the unique physical properties of the two species, specifically the photothermal activity of the WS2NRs upon irradiation with near-infrared (NIR) light and the excitation-dependent luminescence emission of the C-dots. The WS2-C-dot NRs have been shown to be non-cytotoxic and have been successfully employed for multicolour cell imaging and targeted cell killing under NIR irradiation, pointing to their potential utilization as effective therapeutic vehicles.
Department of Chemistry, Ben Gurion University of the Negev, Be'er Sheva, 84105, Israel), Fax.
Sukhendu
S
Nandi
Department of Chemistry, Ben Gurion University of the Negev, Be'er Sheva, 84105, Israel), Fax.
Susanta Kumar
SK
Bhunia
Ilse Katz Institute for Nanoscale Science & Technology, Ben Gurion University of the Negev, Be'er Sheva, 84105, Israel.
Leila
L
Zeiri
Department of Biochemistry and Molecular Biology, Tel Aviv University, Tel Aviv, 69978, Israel.
Maayan
M
Pour
Department of Biochemistry and Molecular Biology, Tel Aviv University, Tel Aviv, 69978, Israel.
Iftach
I
Nachman
Department of Chemistry, Nanomaterials Research Center, Institute of Nanotechnology & Advanced Materials, Bar-Ilan University, Ramat-Gan, 5290002, Israel.
Daniel
D
Raichman
Department of Chemistry, Nanomaterials Research Center, Institute of Nanotechnology & Advanced Materials, Bar-Ilan University, Ramat-Gan, 5290002, Israel.
Jean-Paul Moshe
JM
Lellouche
Department of Chemistry, Ben Gurion University of the Negev, Be'er Sheva, 84105, Israel), Fax.|Ilse Katz Institute for Nanoscale Science & Technology, Ben Gurion University of the Negev, Be'er Sheva, 84105, Israel.
Raz
R
Jelinek
D002244:Carbon / Q000737:chemistry*; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D005456:Fluorescent Dyes / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D007259:Infrared Rays; D008855:Microscopy, Electron, Scanning; D008856:Microscopy, Fluorescence; D043942:Nanotubes / Q000737:chemistry* / Q000633:toxicity; D056951:Photoelectron Spectroscopy; D010789:Phototherapy; D013059:Spectrum Analysis, Raman; D000068936:Theranostic Nanomedicine; D014414:Tungsten / Q000737:chemistry
D005456:Fluorescent Dyes; D002244:Carbon; D014414:Tungsten
carbon dots; cell imaging; fluorescent probes; multicolour fluorescence imaging; nanostructures; photothermal therapy