Survivin as a Novel Biomarker in the Pathogenesis of Acne Vulgaris and Its Correlation to Insulin-Like Growth Factor-I.
Survivin, a member of the inhibitor of apoptosis protein family, has an important role in cell cycle regulation. Insulin-like growth factor-I (IGF-I) is a polypeptide hormone with wide range of biologic effects including stimulation of lipogenesis in sebaceous glands. Their overexpression in some fibrotic disorders suggests a possible implication of both IGF-I and survivin in the pathogenesis of acne and/or acne scars. The current study aimed to assess and correlate serum levels of IGF-I and survivin in patients with active acne vulgaris and postinflammatory acne scars and to evaluate their lesional expressions in comparison to healthy controls. Serum IGF-I and survivin were estimated using commercially available ELISA kits and their tissues expressions were investigated using Western blotting. Our findings suggest that IGF-I and survivin could play potential roles in the pathogenesis of active acne vulgaris and more importantly in postinflammatory acne scars with significant positive correlation coefficient between serum levels of IGF-I and survivin which support IGF-I-/PI3K-/AKT-mediated downregulation of nuclear expression of FoxO transcription factors resulting in enhanced survivin expression.
Department of Dermatology, Faculty of Medicine, Sohag University, P.O. Box 82524, Sohag, Egypt.
Hanan A
HA
Assaf
Department of Dermatology, Faculty of Medicine, Sohag University, P.O. Box 82524, Sohag, Egypt.
Wafaa M
WM
Abdel-Maged
Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, P.O. Box 71524, Assiut, Egypt.
Bakheet E M
BE
Elsadek
Department of Biochemistry and Molecular Biology, Qena Faculty of Medicine, South Valley University, P.O. Box 83523, Qena, Egypt.
Mohammed H
0000-0003-2698-9438
MH
Hassan
Department of Zoology, Faculty of Science, Sohag University, P.O. Box 82524, Sohag, Egypt.
Mohamed A
MA
Adly
Department of Dermatology, Faculty of Medicine, Sohag University, P.O. Box 82524, Sohag, Egypt.
Soher A
SA
Ali
D000152:Acne Vulgaris / Q000378:metabolism / Q000473:pathology*; D000328:Adult; D015415:Biomarkers / Q000378:metabolism*; D015153:Blotting, Western; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins / Q000378:metabolism*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008297:Male; D011379:Prognosis; D000077022:Survivin; D055815:Young Adult
C107489:BIRC5 protein, human; D015415:Biomarkers; D051034:Inhibitor of Apoptosis Proteins; D000077022:Survivin; D007334:Insulin-Like Growth Factor I