Adhesion GPCRs as Novel Actors in Neural and Glial Cell Functions: From Synaptogenesis to Myelination.
Adhesion G-protein-coupled receptors (aGPCRs) are emerging as key regulators of nervous system development and health. aGPCRs can regulate many aspects of neural development, including cell signaling, cell-cell and cell-matrix interactions, and, potentially, mechanosensation. Here, we specifically focus on the roles of several aGPCRs in synapse biology, dendritogenesis, and myelinating glial cell development. The lessons learned from these examples may be extrapolated to other contexts in the nervous system and beyond.
Center for Interdisciplinary Research in Biology (CIRB), Collège de France, CNRS UMR 7241, INSERM U1050, PSL Research University, Paris, France. severine.sigoillot@college-de-france.fr.
Séverine M
SM
Sigoillot
Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO, USA.
Kelly R
KR
Monk
Division of Newborn Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Xianhua
X
Piao
Center for Interdisciplinary Research in Biology (CIRB), Collège de France, CNRS UMR 7241, INSERM U1050, PSL Research University, Paris, France.
Fekrije
F
Selimi
Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO, USA. blharty@wustl.edu.
Breanne L
BL
Harty
D000818:Animals; D001665:Binding Sites; D002448:Cell Adhesion; D015815:Cell Adhesion Molecules / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism*; D054351:Electrical Synapses / Q000378:metabolism*; D006801:Humans; D008024:Ligands; D008958:Models, Molecular; D009024:Morphogenesis; D009186:Myelin Sheath / Q000378:metabolism*; D009413:Nerve Fibers, Myelinated / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009457:Neuroglia / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism*; D011485:Protein Binding; D054730:Protein Interaction Domains and Motifs; D043562:Receptors, G-Protein-Coupled / Q000737:chemistry / Q000378:metabolism*; D015398:Signal Transduction; D013329:Structure-Activity Relationship
D015815:Cell Adhesion Molecules; D008024:Ligands; D009419:Nerve Tissue Proteins; D043562:Receptors, G-Protein-Coupled
Adhesion GPCR; Dendritogenesis; Myelination; Neurodevelopment; Synaptogenesis