Multiple biological activities and molecular docking studies of newly synthesized 3-(pyridin-4-yl)-1H-pyrazole-5-carboxamide chalcone hybrids.
A series of fifteen new chemical entities, 3-(pyridin-4-yl)-1H-pyrazole-5-carboxamide chalcones (6a-o), were synthesized as new hybrids with enriched biological activities compared to their parent molecules. The compounds were characterized by1H NMR,13C NMR, Mass and IR spectral studies. Their antibacterial, anti-inflammatory and antioxidant activities have been evaluated. These compounds showed moderate to good antibacterial, anti-inflammatory and antioxidant activities. The molecular docking analysis was performed with cyclooxygenase enzyme to ascertain the probable binding model.
Department of Organic Chemistry, Madurai Kamaraj University, Madurai 625 021, Tamil Nadu, India.
Rajendran
R
Sribalan
Department of Organic Chemistry, Madurai Kamaraj University, Madurai 625 021, Tamil Nadu, India.
Govindharasu
G
Banuppriya
Department of Organic Chemistry, Madurai Kamaraj University, Madurai 625 021, Tamil Nadu, India.
Maruthan
M
Kirubavathi
Department of Plant Biotechnology, School of Biotechnology, Madurai Kamaraj University, Madurai 625 021, Tamil Nadu, India.
A
A
Jayachitra
Department of Organic Chemistry, Madurai Kamaraj University, Madurai 625 021, Tamil Nadu, India. Electronic address: padimini_tamilenthi@yahoo.co.in.
Vediappen
V
Padmini
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000188:drug therapy; D002599:Chalcone / Q000737:chemistry* / Q000494:pharmacology*; D051545:Cyclooxygenase 1 / Q000378:metabolism; D051546:Cyclooxygenase 2 / Q000378:metabolism; D016861:Cyclooxygenase Inhibitors / Q000737:chemistry / Q000494:pharmacology; D055808:Drug Discovery; D006801:Humans; D062105:Molecular Docking Simulation; D011720:Pyrazoles / Q000737:chemistry* / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D016861:Cyclooxygenase Inhibitors; D011720:Pyrazoles; C000594236:pyrazole-5-carboxamide; D002599:Chalcone; D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2
Anti-inflammatory; Antibacterial; Antioxidant; Chalcone; Pyrazole carboxamide