Circadian preferences, oxidative stress and inflammatory cytokines in bipolar disorder: A community study.
To assess circadian preference among a community sample of people with bipolar disorder, major depression and without any mood disorders. Secondly, we investigated the association of circadian preference with cytokines interleukin-6 (IL-6), interleukin-10 (IL-10) and, tumor necrosis factor alpha (TNF-α) and oxidative stress assessed by thiobarbituric acid reactive substances (TBARS), uric acid and Protein Carbonyl Content (PCC).



A cross-sectional study nested in a population-based sample. Caseness was confirmed with the Structured Clinical Interview for DSM-IV. A sample of 215 participants, in whom we measured circadian preferences, IL-6, IL-10, TNF-α, TBARS, uric acid, PCC. Biological rhythms were evaluated using the Biological Interview of Assessment in Neuropsychiatry.



Bipolar group presented a higher alteration in biological rhythms (40.40±9.78) when compared with the major depression group (36.35±9.18) and control group (27.61±6.89) p<0.001. Subjects with bipolar disorder who were active at night and had a day/night cycle reverse showed decreased levels of IL-6 (t, 44=2.096; p=0.042), (t, 44=2.213; p=0.032), respectively. In the bipolar disorder group subjects who presented day/night cycle reverse had lower TBARS levels (t, 41=2.612; p=0.013). TNF-α were decreased in subjects more active at night with bipolar disorder.



Lower serum levels of IL-6, TNF-α and TBARS were associated with evening preference in bipolar disorder group. These findings suggest that chronotype may alter the levels of interleukins and oxidative stress levels in bipolar and healthy subjects. A better understanding of the role of circadian preferences in levels of interleukins and oxidative stress are needed.
Translational Science on Brain Disorders, Department of Health and Behavior, Catholic University of Pelotas, 373 Gonçalves Chaves, 416C, Pelotas, RS 96015-560, Brazil.
Thaise Campos
TC
Mondin
Universidade Federal do Rio Grande do Sul, Departamento de psiquiatria e medicina legal, Brazil.
Taiane
T
de Azevedo Cardoso
Translational Science on Brain Disorders, Department of Health and Behavior, Catholic University of Pelotas, 373 Gonçalves Chaves, 416C, Pelotas, RS 96015-560, Brazil.
Fernanda Pedrotti
FP
Moreira
Translational Science on Brain Disorders, Department of Health and Behavior, Catholic University of Pelotas, 373 Gonçalves Chaves, 416C, Pelotas, RS 96015-560, Brazil.
Carolina
C
Wiener
Translational Science on Brain Disorders, Department of Health and Behavior, Catholic University of Pelotas, 373 Gonçalves Chaves, 416C, Pelotas, RS 96015-560, Brazil; Department of Psychiatry and Behavioral Sciences, Center For Translational Psychiatry, UT Center of Excellence on Mood Disorders, 1941 East Road, BBSB 5102, Houston, TX 77054, United States.
Jean Pierre
JP
Oses
Translational Science on Brain Disorders, Department of Health and Behavior, Catholic University of Pelotas, 373 Gonçalves Chaves, 416C, Pelotas, RS 96015-560, Brazil.
Luciano Dias
LD
de Mattos Souza
Translational Science on Brain Disorders, Department of Health and Behavior, Catholic University of Pelotas, 373 Gonçalves Chaves, 416C, Pelotas, RS 96015-560, Brazil; Universidade Federal do Rio Grande do Sul, Departamento de psiquiatria e medicina legal, Brazil.
Karen
K
Jansen
Universidade Federal do Rio Grande do Sul, Departamento de psiquiatria e medicina legal, Brazil; Department of Psychiatry and Behavioral Sciences, Center For Translational Psychiatry, UT Center of Excellence on Mood Disorders, 1941 East Road, BBSB 5102, Houston, TX 77054, United States.
Pedro Vieira
PV
da Silva Magalhães
Universidade Federal do Rio Grande do Sul, Departamento de psiquiatria e medicina legal, Brazil; Department of Psychiatry and Behavioral Sciences, Center For Translational Psychiatry, UT Center of Excellence on Mood Disorders, 1941 East Road, BBSB 5102, Houston, TX 77054, United States.
Flávio
F
Kapczinski
Translational Science on Brain Disorders, Department of Health and Behavior, Catholic University of Pelotas, 373 Gonçalves Chaves, 416C, Pelotas, RS 96015-560, Brazil. Electronic address: ricardo.as@uol.com.br.
Ricardo Azevedo
RA
da Silva
D000293:Adolescent; D001714:Bipolar Disorder / Q000097:blood* / Q000276:immunology / Q000503:physiopathology*; D002940:Circadian Rhythm / Q000502:physiology*; D003430:Cross-Sectional Studies; D016207:Cytokines / Q000097:blood*; D003865:Major Depressive Disorder / Q000097:blood / Q000276:immunology / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D018384:Oxidative Stress / Q000502:physiology*; D050050:Protein Carbonylation / Q000502:physiology; D011569:Psychiatric Status Rating Scales; D012111:Residence Characteristics; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D055815:Young Adult
D016207:Cytokines; D017392:Thiobarbituric Acid Reactive Substances
Biological rhythms; Bipolar disorder; Citokynes; Depression; Oxidative stress