Serotonin Syndrome: Prophylactic Treatment With Cyproheptadine.
Despite the numerous advantages of linezolid therapy, one disadvantage continuing to hinder its use is the risk of serotonin syndrome when coadministered with other serotonergic agents. Developing a better understanding of serotonin syndrome is essential for the prevention and management of this potentially life-threatening condition. This report describes a patient with schizophrenia, depression, and severe, acute osteomyelitis. The patient was taking multiple serotonergic agents and required the use of linezolid without the possibility of a sufficient washout period. The severity of the patient's condition in conjunction with increased risk for serotonin syndrome warranted prophylactic treatment with cyproheptadine. The complex pathophysiology of prophylactic treatment of serotonin syndrome with cyproheptadine is worthy of discussion.
Fulton State Hospital, 600 East 5th St, Fulton, MO 65251. Greg.Deardorff@dmh.mo.gov.|Fulton State Hospital, Fulton, Missouri, USA.|University of Missouri-Kansas City School of Pharmacy, Kansas City.|University of Missouri-Columbia School of Medicine, Columbia.|Saint Louis College of Pharmacy, St Louis.
O Greg
OG
Deardorff
Saint Louis College of Pharmacy, St Louis.
Talha
T
Khan
Compass Health, Inc, Columbia, Missouri, USA.
Gaurav
G
Kulkarni
Fulton State Hospital, Fulton, Missouri, USA.
Richard
R
Doisy
Fulton State Hospital, Fulton, Missouri, USA.|University of Missouri-Columbia School of Medicine, Columbia.
Colleen
C
Loehr
D000328:Adult; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D003533:Cyproheptadine / Q000627:therapeutic use*; D004347:Drug Interactions; D006801:Humans; D000069349:Linezolid / Q000009:adverse effects*; D008297:Male; D010019:Osteomyelitis / Q000188:drug therapy; D012702:Serotonin Antagonists / Q000627:therapeutic use*; D020230:Serotonin Syndrome / Q000517:prevention & control*
D000900:Anti-Bacterial Agents; D012702:Serotonin Antagonists; D003533:Cyproheptadine; D000069349:Linezolid