Neurothekeoma in the middle cranial fossa as a rare location: Case report and literature review.
Neurothekeoma is a benign cutaneous nerve sheath tumor usually located in the head and neck region. To date, only a few cases of intracranial location have been reported in the literature. We report an extremely rare case of intracranial neurothekeoma located in the brain parenchyma of the middle cranial fossa. A 55-year-old female patient was operated on at our clinic for a right temporal cystic mass lesion with heterogenic contrast enhancement. Histologically, the tumor had a multinodular hypercellular appearance with a myxoid matrix, peripheral fibrosis, and sclerosis. It was characterized by spindle and epithelioid mononuclear cells, immunochemically positive with diffuse S-100, vimentin, GFAP, PGP 9.5, and NSE, as characteristics of cellular neurothekeomas. After a total surgical resection, there was no need for further adjuvant chemotherapy or radiotherapy. Because there were still unclear aspects regarding the origin, pathogenesis and management of the intracranial neurothekeomas, we decided to contribute to the literature with this case report.
Department of neurosurgery, Karabük university hospital, 78078 Karabük, Turkey. Electronic address: erkutbahabulduk@hotmail.com.
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EB
Bulduk
Department of neurosurgery, Gazi university hospital, Ankara, Turkey.
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Aslan
Department of neurosurgery, Tekirdag government hospital, Tekirdag, Turkey.
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Ö
Öcal
Department of neurosurgery, Gazi university hospital, Ankara, Turkey.
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AM
Kaymaz
D014408:Biomarkers, Tumor / Q000032:analysis*; D035301:Cranial Fossa, Middle / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D008875:Middle Aged; D018321:Neurothekeoma / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery*; D012878:Skin Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery*; D016896:Treatment Outcome
D014408:Biomarkers, Tumor
Intracranial; Nerve sheath tumor; Neurothekeoma