Neuro-imaging evaluation after the first afebrile seizure in children: A retrospective observational study.
OBJECTIVE
To evaluate the role of neuro-imaging in children presenting with the first afebrile seizure and determine factors that influence the outcome of imaging in a large paediatric emergency centre.


METHODS
This is a retrospective review of the medical records of all patients presenting with the first non-febrile seizure to a large paediatric emergency centre in the state of Qatar. Seizure classification followed the current ILAE classification system. Imaging was undertaken in our tertiary hospital and all images were reviewed by experienced neuro-radiologists. Student t test was used for statistical analysis.


RESULTS
Ninety-six children underwent neuro-imaging following the first afebrile seizure. Of them, thirty-two patients (33%) were reported to have abnormalities. Children below the age of two demonstrated a significantly higher percentage of abnormal imaging (59%); (p=0.002). Children presenting with prolonged seizures showed a high percentage of imaging abnormalities (58%); (p=0.003). Children with focal seizures demonstrated a higher percentage of imaging abnormality compared to those presenting with generalized seizures (35% vs 31%). This difference did not reach statistical significance.


CONCLUSIONS
Children below the age of two demonstrated significantly higher percentages of abnormal imaging (59%), as did children presenting with status epilepticus (58%). Neuro-imaging should be considered in infants and those with focal or prolonged seizures. Neuro-imaging informed decision making in 6-8% of children.
Pediatric Neurology Division, Hamad Medical Corporation, Doha, Qatar.
Rana
R
Al-Shami
Pediatric Neurology Division, Hamad Medical Corporation, Doha, Qatar.
Abdulhafeez M
AM
Khair
Pediatric Neurology Division, Hamad Medical Corporation, Doha, Qatar; Weil Cornell Medical College, Qatar.
Mahmoud
M
Elseid
Pediatric Neurology Division, Hamad Medical Corporation, Doha, Qatar; Weil Cornell Medical College, Qatar.
Khalid
K
Ibrahim
Pediatric Neurology Division, Hamad Medical Corporation, Doha, Qatar.
Amna
A
Al-Ahmad
Neuro-radiology Division, Hamad Medical Corporation, Doha, Qatar; Weil Cornell Medical College, Qatar.
Ahmed
A
Elsetouhy
Neuro-radiology Division, Hamad Medical Corporation, Doha, Qatar; Weil Cornell Medical College, Qatar.
Hussein
H
Kamel
Emergency Division, Hamad Medical Corporation, Doha, Qatar; Weil Cornell Medical College, Qatar.
Khalid
K
Al Yafei
Pediatric Neurology Division, Hamad Medical Corporation, Doha, Qatar; Weil Cornell Medical College, Qatar. Electronic address: kmohamed9@hamad.qa.
Khalid
K
Mohamed
D000293:Adolescent; D001921:Brain / Q000000981:diagnostic imaging*; D002648:Child; D002675:Child, Preschool; D004569:Electroencephalography; D005260:Female; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male; D059906:Neuroimaging; D012189:Retrospective Studies; D003294:Seizures, Febrile / Q000000981:diagnostic imaging* / Q000473:pathology*; D014057:Tomography, X-Ray Computed
Afebrile seizure; Neuro-imaging