Cutaneous and Visceral Chronic Granulomatous Disease Triggered by a Rubella Virus Vaccine Strain in Children With Primary Immunodeficiencies.
Persistence of rubella live vaccine has been associated with chronic skin granuloma in 3 children with primary immunodeficiency. We describe 6 additional children with these findings, including 1 with visceral extension to the spleen.
Sorbonne Paris Cité, Paris Descartes University, Institut Imagine.|Paediatric Haemato-Immunology Unit.|National Reference Centre for Primary Immune Deficiencies.
Bénédicte
B
Neven
Biology of Infection Unit, Laboratory of Pathogen Discovery, Inserm U1117.|Biomics, Centre d'Innovation et de Recherche Technologique.
Philippe
P
Pérot
Department of Pathology.
Julie
J
Bruneau
Hematology and Immunology Pediatric Department, CHU Toulouse, Center of Research in Cancerology of Toulouse, Team 16, Institut Universitaire du Cancer de Toulouse-Oncopole.
Marlene
M
Pasquet
Biology of Infection Unit, Laboratory of Pathogen Discovery, Inserm U1117.
Marie
M
Ramirez
Sorbonne Paris Cité, Paris Descartes University, Institut Imagine.|Paediatric Haemato-Immunology Unit.
Jean-Sébastien
JS
Diana
Department of Radiology.
Stéphanie
S
Luzi
Investigation Clinique et Accès aux Ressources Biologiques, Institut Pasteur, Paris.
Nicole
N
Corre-Catelin
Department of Pediatric Surgery.
Christophe
C
Chardot
Sorbonne Paris Cité, Paris Descartes University, Institut Imagine.|Paediatric Haemato-Immunology Unit.|National Reference Centre for Primary Immune Deficiencies.
Despina
D
Moshous
Department of Pathology.|Department of Dermatology.
Stéphanie
S
Leclerc Mercier
Paediatric Haemato-Immunology Unit.|National Reference Centre for Primary Immune Deficiencies.
Nizar
N
Mahlaoui
Pediatric Oncology Hematology Unit/CEREVANCE/CIC 1401, Inserm Centre d'Investigation Clinique Plurithématique, University Hospital of Bordeaux, Pediatric Hospital.
Nathalie
N
Aladjidi
Department of Pathology, Hôpital des Enfants-Hôpital Pellegrin, Bordeaux, France.
Brigitte
B
Le Bail
Sorbonne Paris Cité, Paris Descartes University, Institut Imagine.|Department of Infectious Diseases, Hôpital Necker-Enfants Malades, Assistance Publique Hôpitaux de Paris.|National Reference Centre for Primary Immune Deficiencies.|Biology of Infection Unit, Laboratory of Pathogen Discovery, Inserm U1117.
Marc
M
Lecuit
Department of Dermatology.
Christine
C
Bodemer
Sorbonne Paris Cité, Paris Descartes University, Institut Imagine.|Department of Pathology.
Thierry Jo
TJ
Molina
Sorbonne Paris Cité, Paris Descartes University, Institut Imagine.|Paediatric Haemato-Immunology Unit.|National Reference Centre for Primary Immune Deficiencies.
Stéphane
S
Blanche
Biology of Infection Unit, Laboratory of Pathogen Discovery, Inserm U1117.
Marc
M
Eloit
D001706:Biopsy; D036022:Capsid Proteins / Q000235:genetics; D002648:Child; D005260:Female; D006105:Granulomatous Disease, Chronic / Q000175:diagnosis* / Q000209:etiology*; D018398:Homeodomain Proteins / Q000235:genetics; D006801:Humans; D007150:Immunohistochemistry; D007153:Immunologic Deficiency Syndromes / Q000150:complications* / Q000175:diagnosis / Q000235:genetics; D008297:Male; D009154:Mutation; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012411:Rubella Vaccine / Q000009:adverse effects* / Q000235:genetics; D012867:Skin / Q000473:pathology / Q000821:virology; D013154:Spleen / Q000473:pathology / Q000821:virology
D036022:Capsid Proteins; D018398:Homeodomain Proteins; D012411:Rubella Vaccine; C064658:RAG-1 protein
granuloma; rubella; skin; spleen; vaccine