Recent advances in understanding the extracellular calcium-sensing receptor.
The extracellular calcium-sensing receptor (CaR), a ubiquitous class C G-protein-coupled receptor (GPCR), is responsible for the control of calcium homeostasis in body fluids. It integrates information about external Ca2+and a surfeit of other endogenous ligands into multiple intracellular signals, but how is this achieved? This review will focus on some of the exciting concepts in CaR signaling and pharmacology that have emerged in the last few years.
Department of Biosciences, Biotechnology and Biopharmaceutics, University of Bari , Bari, Italy.
Matilde
0000-0002-9584-7030
M
Colella
Department of Biosciences, Biotechnology and Biopharmaceutics, University of Bari , Bari, Italy.
Andrea
A
Gerbino
Department of Surgery, Brigham & Women's Hospital, Harvard Medical School and VA Boston Healthcare System, West Roxbury, MA, USA.
Aldebaran M
AM
Hofer
Department of Surgery, Brigham & Women's Hospital, Harvard Medical School and VA Boston Healthcare System, West Roxbury, MA, USA.
Silvana
S
Curci
CaR; extracellular Ca2+ sensor; receptor trafficking