Implications of Resident Memory T Cells for Transplantation.
Recent studies have established resident memory T cells (TRM) as the dominant memory lymphocyte population surveying most nonlymphoid tissues. Unlike other memory T cell lineages, TRMdo not recirculate through blood and are permanently confined to their tissue of residence. TRMorchestrate local immune responses and have been shown to accelerate local pathogen control in many experimental infection models. Here we briefly summarize recent advances in TRMdifferentiation, maintenance, and their protective function. While little is known, we have speculated on the potential implications of TRMfor transplantation biology. Areas of emphasis include the role of passenger TRMin controlling latent viral recrudescence in donor organs, donor TRMas a source of graft-versus-host disease, the ability of TRMto potently induce inflammation through sensing and alarm functions, and differentiation of host T cells into TRMin response to local cues inside the allograft. Further investigation of TRMin the context of transplantation might identify therapeutic targets to prolong graft survival.
Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN.|Center for Immunology, University of Minnesota, Minneapolis, MN.
L K
LK
Beura
Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN.|Center for Immunology, University of Minnesota, Minneapolis, MN.
P C
PC
Rosato
Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN.|Center for Immunology, University of Minnesota, Minneapolis, MN.
D
D
Masopust
D006085:Graft Survival / Q000276:immunology*; D006086:Graft vs Host Disease / Q000276:immunology*; D006801:Humans; D007156:Immunologic Memory / Q000276:immunology*; D016377:Organ Transplantation; D016176:T-Lymphocyte Subsets / Q000276:immunology*
T cell biology; basic (laboratory) research/science; clinical research/practice; graft-versus-host disease (GVHD); immunobiology; immunosuppression/immune modulation; lymphocyte biology; lymphocyte biology: differentiation/maturation; organ transplantation in general