B7-H4 is Predictive of Poor Prognosis in Patients with Gastric Cancer.
BACKGROUND Recently, some studies were performed to evaluate the relevance of B7-H4 and gastric cancer (GC) prognosis. However, the results remained controversial. Therefore, we performed the present meta-analysis. MATERIAL AND METHODS We performed a systematic search in PubMed and Web of Science databases. All data were extracted and reviewed from each eligible study independently by 2 investigators. The strength of association between B7-H4 and GC prognosis was assessed by computing odds ratio (OR) with its corresponding 95% confidence interval (CI). RESULTS Six studies that evaluated the association between B7-H4 and GC prognosis were included. The results showed a statistically significant association of B7-H4 and GC prognosis (OR=1.63, 95%CI=1.30-2.03). Furthermore, we conducted subgroup analysis based on source of B7-H4; the results from blood (OR=1.71; 95%CI, 1.09-2.68) and tissue (OR=1.60; 95%CI, 1.03-2.07) indicated B7-H4 was significantly associated with poor prognosis. CONCLUSIONS This meta-analysis suggests that GC patients with high B7-H4 have poor prognosis.
Department of Gastroenterology, The First People's Hospital of Shangqiu, Shangqiu, Henan, China (mainland).
YongHui
Y
Cui
Department of Gastroenterology, The First People's Hospital of Shangqiu, Shangqiu, Henan, China (mainland).
ZhiHan
Z
Li
D006801:Humans; D009367:Neoplasm Staging; D016017:Odds Ratio; D011379:Prognosis; D013274:Stomach Neoplasms / Q000097:blood / Q000378:metabolism* / Q000473:pathology; D060907:V-Set Domain-Containing T-Cell Activation Inhibitor 1 / Q000097:blood / Q000378:metabolism*
D060907:V-Set Domain-Containing T-Cell Activation Inhibitor 1; C475826:VTCN1 protein, human