Necrotizing: A historical perspective.
Necrotizing enterocolitis is a devastating disease afflicting premature infants, though after 50 years of investigation, the pathophysiology remains elusive. This report describes the possible etiologic factors from a historical perspective, and outlines the importance of human milk, intestinal blood flow, and intestinal blood flow changes from a developmental perspective over the last 40-50 years.
Department of Pediatrics, Chief Scientific Officer, Northshore University, Healthsystem, Clinical Professor of Pediatrics, University of Chicago, Pritzker School of Medicine. Electronic address: Mcaplan@northshore.org.
Michael S
MS
Caplan
Eliza Henry Barnes chair in Neonatology, Rainbow Babies and Children's Hospital.
Avroy
A
Fanaroff
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001942:Breast Feeding / Q000266:history; D003422:Critical Care / Q000266:history*; D004750:Enteral Nutrition; D020345:Enterocolitis, Necrotizing / Q000266:history* / Q000517:prevention & control / Q000628:therapy; D000069196:Gastrointestinal Microbiome; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D007227:Infant Nutritional Physiological Phenomena; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000266:history* / Q000517:prevention & control / Q000628:therapy; D007234:Infant, Premature; D008895:Milk, Human / Q000276:immunology
D000900:Anti-Bacterial Agents
NEC; human milk; intestinal ischemia; microbiome