Chemical components of respirable particulate matter associated with emergency hospital admissions for type 2 diabetes mellitus in Hong Kong.
Epidemiological studies have shown that short-term exposure to particulate matter (PM) mass is associated with diabetes morbidity and mortality, although inconsistencies still exist. Variation of chemical components in PM may have contributed to these inconsistencies. We hypothesize that certain components of respirable particulate matter (PM10), not simply PM10mass, can exacerbate symptoms or cause acute complications for type 2 diabetes mellitus (T2DM).



We used a Poisson time-series model to examine the association between 17 chemical components of PM10and daily emergency hospital admissions for T2DM among residents aged 65years or above from January 1998 to December 2007 in Hong Kong. We estimated excess risk (ER%) for T2DM hospitalizations per interquartile range (IQR) increment in chemical component concentrations of days at lag0through lag3, and the moving average of the same-day and previous-day (lag0-1) in single-pollutant models. To further evaluate the independent effects of chemical components on T2DM, we controlled for PM10mass, major PM10chemical components, and gaseous pollutants in two-pollutant models.



In the single-pollutant models, PM10components associated with T2DM admissions include: elemental carbon, organic carbon, nitrate, and nickel. The ER% estimates per IQR increment at lag0-1for these four components were 3.79% (1.63, 5.95), 3.74% (0.83, 6.64), 4.58% (2.17, 6.99), and 1.91% (0.43, 3.38), respectively. Risk estimates for nitrate and elemental carbon were robust to adjustment for co-pollutant concentrations.



Short-term exposure to some PM10chemical components such as nitrate and elemental carbon increases the risk of acute complications or exacerbation of symptoms for the T2DM patients. These findings may have potential biological and policy implications.
School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
Shengzhi
S
Sun
School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
Hong
H
Qiu
Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong SAR, China.
Kin-Fai
KF
Ho
School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China. Electronic address: linweit@hku.hk.
Linwei
L
Tian
D000368:Aged; D000369:Aged, 80 and over; D000393:Air Pollutants / Q000737:chemistry* / Q000633:toxicity; D002244:Carbon / Q000032:analysis; D003924:Diabetes Mellitus, Type 2 / Q000139:chemically induced / Q000453:epidemiology* / Q000503:physiopathology; D018450:Disease Progression; D004630:Emergencies / Q000453:epidemiology; D005260:Female; D006723:Hong Kong; D006760:Hospitalization; D006801:Humans; D008297:Male; D008875:Middle Aged; D008962:Models, Theoretical; D009532:Nickel / Q000032:analysis; D009566:Nitrates / Q000032:analysis; D052638:Particulate Matter / Q000737:chemistry* / Q000633:toxicity
D000393:Air Pollutants; D009566:Nitrates; D052638:Particulate Matter; D002244:Carbon; D009532:Nickel
Air pollution; Chemical component; Diabetes; Particulate matter; Time-series analysis