Evaluation of an asymmetric anterior glottic web in an excised canine larynx model.
The main objective of the study is to model asymmetry within anterior glottic webs in excised larynges using sutures and apply aerodynamic and acoustic analyses. Anterior glottic webs (AGW) were modeled in eight excised larynges using sutures secured at the level of the glottis to mimic the scar tissue of the web. Each of the eight larynges were tested under three different pressure increments for each of the three models of AGW: symmetric, vertically asymmetric, and laterally asymmetric. Phonation threshold pressure (PTP) and flow (PTF) differed significantly across AGW conditions (p = 0.006 and p = 0.005, respectively). Additionally, vocal efficiency was significantly different among conditions (p = 0.005) as well as significantly lower in the asymmetric groups (p = 0.015 and p = 0.007). Perturbation measures were not significantly different across conditions. Correlation dimension (D2) was significantly different at PTP, 1.25 × PTP, and 1.5 × PTP (p = 0.003, p = 0.010, and p < 0.001, respectively) as well as significantly higher in the asymmetric groups at each pressure increment. The increased PTP, PTF, and D2 values as well as decreased vocal efficiency among the asymmetric conditions indicates a significant decrease in vocal function, and thus represents that asymmetries could be a contributing factor to the pathological symptoms associated with glottic webs.
Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, 53792, USA.
Allyson C
AC
Pulvermacher
Department of Otolaryngology-Head and Neck Surgery, Eye, Ear, Nose, Throat Hospital of Fudan University, Shanghai, 200031, China.
Chao
C
Xue
Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, 53792, USA.
Robert
R
Leggon
Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, 53792, USA.
Randal
R
Mills
Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, 53792, USA. jjjiang@wisc.edu.|Department of Otolaryngology-Head and Neck Surgery, Eye, Ear, Nose, Throat Hospital of Fudan University, Shanghai, 200031, China. jjjiang@wisc.edu.|, 1300 University Avenue, 2745 Medical Sciences Center, Madison, WI, 53706, USA. jjjiang@wisc.edu.
Jack J
JJ
Jiang
D000162:Acoustics; D000818:Animals; D004285:Dogs; D005931:Glottis / Q000473:pathology* / Q000503:physiopathology; D007825:Laryngectomy; D007830:Larynx / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery; D023421:Models, Animal; D010699:Phonation / Q000502:physiology; D011312:Pressure; D014059:Tongue / Q000473:pathology* / Q000503:physiopathology
Acoustic analysis; Aerodynamic analysis; Anterior glottic web; Asymmetry; Excised larynx