Syndrome in question: antisynthetase syndrome (anti-PL-7).
Antisynthetase syndrome is a rare autoimmune disease characterized by interstitial lung disease and/or inflammatory myositis, with positive antisynthetase antibodies (anti-Jo-1, anti-PL-7, anti-PL-12, ZO, OJ, anti-KE or KS). Other symptoms described include: non-erosive arthritis, fever, Raynaud's phenomenon, and "mechanic's hands." The first therapeutic option is corticotherapy, followed by other immunosuppressants. The prognosis of the disease is quite limited when compared to other inflammatory myopathies with negative antisynthetase antibodies.
Universidade Estadual Paulista "Júlio de Mesquita Filho" (Unesp), Botucatu, SP, Brazil.
Ana Cláudia Cavalcante
AC
Esposito
Universidade Estadual Paulista "Júlio de Mesquita Filho" (Unesp), Botucatu, SP, Brazil.
Tatiana Cristina
TC
Gige
Universidade Estadual Paulista "Júlio de Mesquita Filho" (Unesp), Botucatu, SP, Brazil.
Hélio Amante
HA
Miot
D000328:Adult; D005260:Female; D006229:Hand Dermatoses / Q000150:complications; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000150:complications / Q000000981:diagnostic imaging; D009220:Myositis / Q000150:complications / Q000175:diagnosis*; D009260:Nail Diseases / Q000150:complications; D014054:Tomography