Lipid-based surface engineering of PLGA nanoparticles for drug and gene delivery applications.
The use of poly(lactic-co-glycolic acid) (PLGA)-based nanocarriers presents several major challenges, including their synthetic hydrophobic surface, low transfection efficiency, short circulation half-life, and nonspecific tissue distribution. Numerous engineering strategies have been employed to overcome these problems, with lipid-based surface functionalization of PLGA nanoparticles (NPs) showing promising results in the development of PLGA-based clinical nanomedicines. Surface engineering with different lipids enhances the target specificity of the carrier and improves its physicochemical properties as well as NP-cell associations, such as cellular membrane permeability, immune responses, and long circulation half-life in vivo. This review focuses on recent advances in the lipid-based surface engineering of PLGA NPs for drug and gene delivery applications.
School of Integrative Engineering, Chung-Ang University, Seoul, Republic of Korea ; Department of Biomedical Science, CHA University, Seongnam-si, Gyeonggi-do Republic of Korea.
Rajendran Jc
RJ
Bose
Department of Biomedical Science, CHA University, Seongnam-si, Gyeonggi-do Republic of Korea.
Soo-Hong
SH
Lee
School of Integrative Engineering, Chung-Ang University, Seoul, Republic of Korea.
Hansoo
H
Park
Biomimetic fucntionalization; Cell membrane derived lipid vesicles; Controlled drug release; Gene delivery; Lipids; PLGA nanoparticle; Self assembly; Surface engineering