Association between miR-199a rs74723057 and MET rs1621 polymorphisms and the risk of hepatocellular carcinoma.
MicroRNAs (miRNAs) can regulate gene expression at post-transcriptional levels, thereby influence cancer risk. The aim of the current study is to investigate association between miR-199a rs74723057 and MET rs1621 and HCC risk in 1032 HCC patients and 1060 cancer-free controls. These two SNPs were genotyped by using the Agena MassARRAY genotyping system. Odds ratio (OR) and 95% confidence interval (95%CI) were calculated to assess the strength of the associations. We found that compared with the wild-type AA genotype of MET rs1621, the variant GG genotype was associated with a decreased risk for HCC (OR = 0.24, 95% CI = 0.06-0.96, P = 0.043). No association between miR-199a rs74723057 and HCC risk was observed. In addition, an interaction effect on HCC risk between the selected two SNPs was found. Among those who carried the CG/GG genotypes of miR-199a rs74723057, those who carried the GG genotype of MET rs1621 had a reduced risk of HCC, when compared with those who carried the AG/AA genotypes of MET rs1621 (OR = 0.15, 95% CI = 0.03~0.73, P for interaction = 0.018). Our results suggest that MET rs1621 polymorphism, alone and combined with miR-199a rs74723057, may influence susceptibility to HCC. Further large-scale association studies and functional studies are needed to validate our findings.
Department of Epidemiology, School of Public Health, Guilin Medical University, Guilin 541004, China.
Qianqian
Q
Wang
Department of Epidemiology, School of Public Health, Guilin Medical University, Guilin 541004, China.
Xiangyuan
X
Yu
Department of Epidemiology, School of Public Health, Guilin Medical University, Guilin 541004, China.
Qiang
Q
Li
Department of Epidemiology, School of Public Health, Guilin Medical University, Guilin 541004, China.
Linyuan
L
Qin
Department of Epidemiology, School of Public Health, Guilin Medical University, Guilin 541004, China.
Shengkui
S
Tan
Department of Epidemiology and Health Statistics, Guangxi Medical University, Nanning 530021, China.
Xiaoyun
X
Zeng
Department of Epidemiology and Health Statistics, Guangxi Medical University, Nanning 530021, China.
Xiaoqiang
X
Qiu
Laboratory of Hepatobiliary and Pancreatic Surgery, The Affiliated Hospital of Guilin Medical University, Guilin 541001, China.
Bo
B
Tang
Laboratory of Hepatobiliary and Pancreatic Surgery, The Affiliated Hospital of Guilin Medical University, Guilin 541001, China.
Junfei
J
Jin
Laboratory of Hepatobiliary and Pancreatic Surgery, The Affiliated Hospital of Guilin Medical University, Guilin 541001, China.
Weijia
W
Liao
Laboratory of Hepatobiliary and Pancreatic Surgery, The Affiliated Hospital of Guilin Medical University, Guilin 541001, China.
Moqin
M
Qiu
Laboratory of Hepatobiliary and Pancreatic Surgery, The Affiliated Hospital of Guilin Medical University, Guilin 541001, China.
Lijun
L
Tan
Laboratory of Hepatobiliary and Pancreatic Surgery, The Affiliated Hospital of Guilin Medical University, Guilin 541001, China.
Gaofeng
G
He
Department of Epidemiology, School of Public Health, Guilin Medical University, Guilin 541004, China.
Xiaomei
X
Li
Laboratory of Hepatobiliary and Pancreatic Surgery, The Affiliated Hospital of Guilin Medical University, Guilin 541001, China.|Guangxi Key Laboratory of Molecular Medicine in Liver Injury and Repair, Guilin Medical University, Guilin 541001, China.
Songqing
S
He
Department of Epidemiology and Health Statistics, Guangxi Medical University, Nanning 530021, China.|Department of Epidemiology, School of Public Health, Guilin Medical University, Guilin 541004, China.
Hongping
H
Yu
D006528:Carcinoma, Hepatocellular / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics*; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D020411:Oligonucleotide Array Sequence Analysis; D020641:Polymorphism, Single Nucleotide; D019859:Proto-Oncogene Proteins c-met / Q000235:genetics*
D035683:MicroRNAs; C531408:mirn199 microRNA, human; C491743:MET protein, human; D019859:Proto-Oncogene Proteins c-met
MET; hepatocellular carcinoma; miR-199a; risk; single nucleotide polymorphism