Associations of A-FABP with Anthropometric and Metabolic Indices and Inflammatory Cytokines in Obese Patients with Newly Diagnosed Type 2 Diabetes.
The study aimed to evaluate the relationship between anthropometric and metabolic indices, inflammatory cytokines, and adipocyte fatty acid-binding protein (A-FABP) in obese patients with newly diagnosed type 2 diabetes. The study included 48 nonobese subjects with newly diagnosed type 2 diabetes, 42 obese subjects with newly diagnosed type 2 diabetes, 30 simple obese subjects, and 30 matched normal subjects. Serum A-FABP was assessed by enzyme-linked immunosorbent assay. Pearson's correlations and multiple linear regression stepwise analysis were used to analyze correlations of A-FABP with anthropometric and metabolic indices and inflammatory cytokines. Obese subjects with newly diagnosed type 2 diabetes had elevated A-FABP compared to normal control, nondiabetic obese patients, and nonobese diabetic patients. A-FABP was significantly correlated with glycated hemoglobin A1C (HbA1C), BMI, triglyceride, Homeostasis Model Assessment Index (HOMA-IR), waist hip rate, C-reactive protein, IL-6, and HDL-C in obese subjects with type 2 diabetes. In multiple linear regression stepwise analysis, BMI, HbA1C, and HOMA-IR were significantly independent determinants for A-FABP. BMI, HbA1C, and HOMA-IR are independently associated with A-FABP in obese subjects with newly diagnosed type 2 diabetes. A-FABP may be related to insulin resistance and inflammation in type 2 diabetes and concomitant obesity.
Department of Endocrinology, People's Hospital of Liaocheng, Shandong 252000, China.
Guifen
G
Niu
Department of Endocrinology, People's Hospital of Liaocheng, Shandong 252000, China.
Jian
J
Li
Department of Urology, People's Hospital of Liaocheng, Shandong 252000, China.
Huaiguo
H
Wang
Department of Endocrinology, People's Hospital of Liaocheng, Shandong 252000, China.
Yuan
Y
Ren
Department of Endocrinology, People's Hospital of Liaocheng, Shandong 252000, China.
Jie
0000-0002-1530-9735
J
Bai
D000886:Anthropometry; D049628:Body Size / Q000276:immunology*; D015984:Causality; D002681:China / Q000453:epidemiology; D015897:Comorbidity; D016207:Cytokines / Q000276:immunology*; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000276:immunology*; D050556:Fatty Acid-Binding Proteins / Q000097:blood / Q000276:immunology*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000453:epidemiology / Q000276:immunology*; D018836:Inflammation Mediators / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology / Q000276:immunology*; D015995:Prevalence; D012307:Risk Factors
D016207:Cytokines; C493410:FABP4 protein, human; D050556:Fatty Acid-Binding Proteins; D018836:Inflammation Mediators