Leptin Level in Patients with Type 2 Diabetes Mellitus after Fetal Pancreatic Stem Cell Transplant.
We aimed to determine leptin level in patients with type 2 diabetes mellitus after fetal pancreatic stem cell transplant.



We examined 14 patients (aged 43-63 years old) with type 2 diabetes mellitus, which we subsequently divided into 2 groups and examined. Group 1 comprised 8 patients who received fetal pancreatic stem cell transplant (cells were 16-18 wk gestation) performed by intravenous infusion; group 2 comprised 6 patients in the control group who were on hypoglycemic tablet therapy or insulin therapy. The quantity of fetal stem cells infused was 5 to 6 × 106. We analyzed leptin and C-peptide levels in patients both before and 3 months after the fetal pancreatic stem cell transplant procedure.



In patients with type 2 diabetes mellitus, fetal pancreatic stem cell transplant led to a significant increase in leptin levels, from 11.01 ng/mL to 16.29 ng/mL, after 3 months (P < .05).



Leptin level increase significantly within 3 months after fetal pancreatic stem cell transplant in patients with type 2 diabetes mellitus.
From the Department of Internal Medicine, National Scientific Medical Research Center, Astana, Kazakhstan.
Olga
O
Ulyanova
Zhannat
Z
Taubaldieva
Saltanat
S
Tuganbekova
Samat
S
Saparbayev
Natalya
N
Kim
Rakhat
R
Trimova
Larissa
L
Kozina
Galiya
G
Shaimardanova
D000328:Adult; D015415:Biomarkers / Q000097:blood; D002096:C-Peptide / Q000097:blood; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000175:diagnosis / Q000601:surgery*; D005260:Female; D053686:Fetal Stem Cells / Q000378:metabolism / Q000637:transplantation*; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D016035:Pancreas Transplantation / Q000009:adverse effects / Q000379:methods*; D011446:Prospective Studies; D013997:Time Factors; D016896:Treatment Outcome; D015854:Up-Regulation
D015415:Biomarkers; D002096:C-Peptide; D007004:Hypoglycemic Agents; D020738:Leptin