Brief Report: A Second Primary Endodermal Sinus Tumor 9 Years after Initial Diagnosis.
BACKGROUND
Ovarian yolk sac tumors (YSTs) are rare malignant germ cell tumors known to present unilaterally, allowing for fertility-sparing surgical treatment with adjuvant chemotherapy. The few published cases of bilateral ovarian involvement were at the time of original diagnosis in patients with widely metastatic disease. We present, to our knowledge, the first case of bilateral ovarian YSTs, diagnosed several years apart, and discuss the implications on recurrence and tumor marker surveillance for these tumors.


METHODS
This is a case of a young woman who re-presented 9 years after initial treatment, with a YST in the contralateral ovary.


CONCLUSIONS
YSTs are well established as unilateral tumors, however, in rare cases such as this, they might reappear years later on the contralateral ovary.
Department of Gynecology and Obstetrics, Johns Hopkins Hospital, Baltimore, Maryland. Electronic address: lmoukar1@jhmi.edu.
Lea A
LA
Moukarzel
Department of Gynecology and Obstetrics, Johns Hopkins Hospital, Baltimore, Maryland.
Kimberly
K
Levinson
Department of Gynecology and Obstetrics, Johns Hopkins Hospital, Baltimore, Maryland.
Francis C
FC
Grumbine
D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D018240:Endodermal Sinus Tumor / Q000175:diagnosis*; D005260:Female; D006801:Humans; D009373:Neoplasms, Germ Cell and Embryonal / Q000175:diagnosis*; D016609:Neoplasms, Second Primary / Q000175:diagnosis*; D010051:Ovarian Neoplasms / Q000175:diagnosis*; D013997:Time Factors
Alpha-fetoprotein; Malignant ovarian germ cell tumors; Yolk sac tumors