Successful Treatment of a Complex Vascular Malformation With Sirolimus and Surgical Resection.
Management of complex vascular malformation represents a challenge as it may include a wide variety of options such as embolization, laser therapy, sclerotherapy, and surgical resection but may lead to significant morbidity and is associated with high recurrence rates. In extreme and/or recurrent cases, successful use of sirolimus has been described. We report a case of large unresectable complex venous malformation treated with oral sirolimus for 24 months. Therapy was well tolerated. Patient had substantial improvement in symptoms and shrinkage of the lesion. The Medical Therapy made excision of the malformation possible and patient had a successful surgical procedure. This report provides further evidence that sirolimus should be considered as part of the armamentarium in the management of these rare conditions.
*Department of Plastic Surgery, Hospital das Clinicas, University of Sao Paulo Medical School, Sao Paulo, Brazil †Harvard Medical School, Boston Children's Hospital, Boston, MA.
Dov C
DC
Goldenberg
Marcelo
M
Carvas
Denise
D
Adams
Marcelo
M
Giannotti
Rolf
R
Gemperli
D005260:Female; D006801:Humans; D019651:Plastic Surgery Procedures; D016879:Salvage Therapy / Q000379:methods; D020123:Sirolimus / Q000627:therapeutic use; D013514:Surgical Procedures, Operative; D016896:Treatment Outcome; D054079:Vascular Malformations / Q000188:drug therapy* / Q000601:surgery; D055815:Young Adult
D020123:Sirolimus