Macrophage Metabolism Shapes Angiogenesis in Tumors.
In this issue, Wenes et al. (2016) show that REDD1, an mTOR inhibitor induced by hypoxia, enhances glycolysis in tumor-associated macrophages (TAMs). Metabolic competition for glucose between TAMs and endothelial cells leads to an abnormal, leaky vascular network. Targeting REDD1 normalizes glycolysis in TAMs, stabilizes the vascular network, and inhibits metastasis.
Istituto Clinico Humanitas IRCCS, via Manzoni 56, 20089 Rozzano, Italy; Humanitas University, via Manzoni 113, 20089 Rozzano, Italy. Electronic address: alberto.mantovani@humanitasresearch.it.
Alberto
A
Mantovani
Istituto Clinico Humanitas IRCCS, via Manzoni 56, 20089 Rozzano, Italy; Department of Medical Biotechnology and Translational Medicine, University of Milan, 20122 Milan, Italy.
Massimo
M
Locati
D006019:Glycolysis; D006801:Humans; D008264:Macrophages; D009024:Morphogenesis; D009369:Neoplasms; D009389:Neovascularization, Pathologic