An Ephrin-Eph Tug and Push in Left-Right Organ Placement.
During development, the placement of internal organs asymmetrically along the left-right axis is critical for their proper adult function. Reporting in Developmental Cell, Cayuso et al. (2016) demonstrate an active role of the endoderm in this process, challenging the prior view that the endoderm is passively pushed by the mesoderm.
Laboratory of Genetics, Department of Medical Genetics, University of Wisconsin-Madison, Madison, WI 53706, USA.
Leah
L
Nantie
Laboratory of Genetics, Department of Medical Genetics, University of Wisconsin-Madison, Madison, WI 53706, USA; Department of Pediatrics, University of California, San Diego, CA 92093, USA. Electronic address: xsun@wisc.edu.
Xin
X
Sun
D004707:Endoderm; D036342:Ephrins; D006801:Humans; D008648:Mesoderm; D011485:Protein Binding; D036081:Receptors, Eph Family; D015398:Signal Transduction
D036342:Ephrins; D036081:Receptors, Eph Family