Vaccine-strain herpes zoster found in the trigeminal nerve area in a healthy child: A case report.
A previously healthy 2-year-old girl, vaccinated for varicella at 17 months, was admitted because of left-sided facial herpes zoster caused by vaccine-strain varicella-zoster virus (VZV). She recovered fully with no complication after intravenous treatment using acyclovir. Earlier reports have described that herpes zoster (HZ) rashes caused by vaccine-strain VZV tend to occur on the dermis corresponding to the skin area where the varicella vaccine was received. However, rashes appeared on this girl only in the trigeminal nerve area, which is unrelated to the vaccinated site. Results underscore the importance of distinguishing vaccine-strain VZV from wild-type VZV whenever encountering HZ cases after vaccination, even in immunocompetent children, irrespective of the skin lesion site. Monitoring vaccine-strain HZ incidence rates is expected to elucidate many aspects of varicella vaccine safety.
Department of Pediatrics, Kitano Hospital, The Tazuke Kofukai Medical Research Institute, 2-4-20, Ohgimachi, Kita-ku, Osaka city, Osaka, Japan.
Sayaka
S
Iwasaki
Department of Pediatrics, Kitano Hospital, The Tazuke Kofukai Medical Research Institute, 2-4-20, Ohgimachi, Kita-ku, Osaka city, Osaka, Japan.
Kouji
K
Motokura
Department of Pediatrics, Kitano Hospital, The Tazuke Kofukai Medical Research Institute, 2-4-20, Ohgimachi, Kita-ku, Osaka city, Osaka, Japan.
Yoshitaka
Y
Honda
Department of Pediatrics, Kitano Hospital, The Tazuke Kofukai Medical Research Institute, 2-4-20, Ohgimachi, Kita-ku, Osaka city, Osaka, Japan.
Masamitsu
M
Mikami
Department of Pediatrics, Kitano Hospital, The Tazuke Kofukai Medical Research Institute, 2-4-20, Ohgimachi, Kita-ku, Osaka city, Osaka, Japan.
Daisuke
D
Hata
Department of Pediatrics, Kitano Hospital, The Tazuke Kofukai Medical Research Institute, 2-4-20, Ohgimachi, Kita-ku, Osaka city, Osaka, Japan. Electronic address: ahata@kitano-hp.or.jp.
Atsuko
A
Hata
D000212:Acyclovir / Q000008:administration & dosage; D000998:Antiviral Agents / Q000008:administration & dosage; D002675:Child, Preschool; D005260:Female; D006562:Herpes Zoster / Q000188:drug therapy / Q000821:virology*; D053061:Herpes Zoster Vaccine / Q000008:administration & dosage* / Q000009:adverse effects*; D014645:Herpesvirus 3, Human / Q000302:isolation & purification*; D006801:Humans; D016896:Treatment Outcome; D014276:Trigeminal Nerve / Q000821:virology*
D000998:Antiviral Agents; D053061:Herpes Zoster Vaccine; D000212:Acyclovir