The Effect of Low-Intensity Ultrasound on Brain-Derived Neurotropic Factor Expression in a Rat Sciatic Nerve Crushed Injury Model.
Low-intensity ultrasound (LIU) can improve nerve regeneration and functional recovery after peripheral nerve crush injury, but the underlying mechanism is not clear. The objective of this study was to examine the effects of LIU on rat sciatic crush injury and to investigate a possible molecular mechanism. Adult male Sprague-Dawley rats underwent left sciatic nerve crush surgery and were then randomized into two groups: a treatment group that received LIU every other d, and a control group that received sham exposure. Compared with rats in the control group, rats in the treatment group had higher sciatic nerve function indexes, compound muscle action potentials, wet weight ratios of the target muscle and mRNA expression of brain-derived neurotropic factor (BDNF) in the crushed nerve and ipsilateral dorsal root ganglia. Our findings suggest that LIU might promote injured nerve regeneration by stimulating BDNF release.
Department of Ultrasound, Shanghai Huashan Hospital, Fudan University, Shanghai, China.
Xue-Jun
XJ
Ni
Department of Histology and Embryology of Medical College, Nantong University, Nantong, Jiangsu, China.
Xiao-Dong
XD
Wang
Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Nantong, Jiangsu, China.
Ya-Hong
YH
Zhao
Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Nantong, Jiangsu, China.
Hua-Lin
HL
Sun
Department of Rehabilitation, Affiliated Hospital to Nantong University, Nantong, Jiangsu, China.
Yu-Ming
YM
Hu
Department of Histology and Embryology of Medical College, Nantong University, Nantong, Jiangsu, China.
Jian
J
Yao
Department of Ultrasound, Shanghai Huashan Hospital, Fudan University, Shanghai, China. Electronic address: y_wang1111@hotmail.com.
Yi
Y
Wang
D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism*; D000071576:Crush Injuries / Q000378:metabolism / Q000628:therapy*; D004195:Disease Models, Animal; D008297:Male; D009416:Nerve Regeneration / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D020127:Recovery of Function; D012584:Sciatic Nerve / Q000293:injuries* / Q000378:metabolism / Q000503:physiopathology; D014464:Ultrasonic Therapy / Q000379:methods*
D019208:Brain-Derived Neurotrophic Factor
Brain-derived neurotropic factor; Nerve regeneration; Peripheral nerve injury; Ultrasound therapy