NK Cell Responses Redefine Immunological Memory.
Immunological memory has traditionally been regarded as a unique trait of the adaptive immune system. Nevertheless, there is evidence of immunological memory in lower organisms and invertebrates, which lack an adaptive immune system. Despite their innate ability to rapidly produce effector cytokines and kill virally infected or transformed cells, NK cells also exhibit adaptive characteristics such as clonal expansion, longevity, self-renewal, and robust recall responses to antigenic or nonantigenic stimuli. In this review, we highlight the intracellular and extracellular requirements for memory NK cell generation and describe the emerging evidence for memory precursor NK cells and their derivation.
Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Nicholas M
0000-0001-5751-0480
NM
Adams
Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Timothy E
0000-0002-0104-4932
TE
O'Sullivan
Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Clair D
CD
Geary
Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Jenny M
JM
Karo
Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520; and.
Robert A
0000-0001-6868-7193
RA
Amezquita
Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520; and.
Nikhil S
0000-0002-7045-7837
NS
Joshi
Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520; and.
Susan M
SM
Kaech
Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065; sunj@mskcc.org.|Department of Immunology and Microbial Pathogenesis, Weill Cornell Medical College, New York, NY 10065.
Joseph C
JC
Sun
D056704:Adaptive Immunity; D000818:Animals; D002454:Cell Differentiation; D006801:Humans; D007113:Immunity, Innate; D007156:Immunologic Memory; D007448:Invertebrates / Q000276:immunology; D007694:Killer Cells, Natural / Q000276:immunology*