Solanerioside A, an unusual 14,15-dinor-cyclophytane glucoside from the leaves of Solanum erianthum.
Solanerioside A (1), the first example of a diterpenoid glucoside featuring a 14,15-dinor-cyclophytane scaffold, together with three known terpene glucosides (2-4) were isolated from the methanol extract of the leaves of Solanum erianthum (Solanaceae). The structure of 1 was mainly characterised on the basis of extensive spectroscopic analyses, especially from the 2D NMR spectra. In addition, the spectroscopic data of (6E, 10E)-5,12-dihydroxy-β-nerolidol 5-O-β-D-glucopyranoside (3) were reported for the first time. However, these compounds did not display obvious inhibition of LPS-induced NO release in RAW264.7 cells and anti-tumour activity against A549, HepG2, Hela and MCF-7 cells in vitro.
a School of Pharmaceutical Sciences , Sun Yat-sen University , Guangzhou , China.
Shi-Yi
SY
Peng
a School of Pharmaceutical Sciences , Sun Yat-sen University , Guangzhou , China.
Hang
H
Li
a School of Pharmaceutical Sciences , Sun Yat-sen University , Guangzhou , China.|b Guangdong Technology Research Center for Advanced Chinese Medicine , Guangzhou , China.
De-Po
DP
Yang
a School of Pharmaceutical Sciences , Sun Yat-sen University , Guangzhou , China.
Bai
B
Bai
a School of Pharmaceutical Sciences , Sun Yat-sen University , Guangzhou , China.|b Guangdong Technology Research Center for Advanced Chinese Medicine , Guangzhou , China.
Long-Ping
LP
Zhu
a School of Pharmaceutical Sciences , Sun Yat-sen University , Guangzhou , China.
Qin
Q
Liu
a School of Pharmaceutical Sciences , Sun Yat-sen University , Guangzhou , China.
Juan
J
Shen
a School of Pharmaceutical Sciences , Sun Yat-sen University , Guangzhou , China.|b Guangdong Technology Research Center for Advanced Chinese Medicine , Guangzhou , China.
Zhi-Min
ZM
Zhao
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D008070:Lipopolysaccharides / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D009569:Nitric Oxide / Q000378:metabolism; D010936:Plant Extracts / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry*; D000067996:RAW 264.7 Cells; D032322:Solanum / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared
D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D005960:Glucosides; D008070:Lipopolysaccharides; D010936:Plant Extracts; C000616772:solanerioside A; D009569:Nitric Oxide
Solanaceae; Solanum erianthum; diterpenoid glucoside; sesquiterpene glucoside