Neurobrucellosis and cerebral venous sinus thrombosis: a case report.
OBJECTIVE
To present a case of co-occurrence of neurobrucellosis and cerebral venous sinus thrombosis.


METHODS
Case report.


METHODS
We presented 49-year-old Caucasian domicile female-farmer with a history of headache, weakness, and vomiting for a period of three months. Also, she had significant papilledema. We diagnosed rare co-morbidity of neurobrucellosis (confirmed after ELISA-test in serum samples and CSF analysis of pleocytosis/increase in protein/decrease in glucose level) in the setting of cerebral venous thrombosis developed in left sigmoid/left transverse sinus (confirmed after MRV of brain). Favorable outcome was achieved by applying protracted polymicrobial antibiotic therapy and heparin.


CONCLUSIONS
It may be challenging to diagnose neurobrucellosis, especially in patients with atypical presentation and abortive clinical forms. The co-morbidity of neurobrucellosis and cerebral venous sinus thrombosis is uncommon. However, it provides a possibility of brucella-colonization in cerebral venous sinuses as a potential hidden link between them.


CONCLUSIONS
Patients with severe and persistent headache, as well as other neurological symptoms/signs should be considered for neurobrucellosis in endemic, but also in brucella non-endemic regions due to migrations. According to literature survey, this co-occurrence of neurobrucellosis and cerebral venous sinus thrombosis is third one reported from Europe.
a Department of Neurology , University Cinical Centre Tuzla, University of Tuzla , Tuzla , Bosnia and Herzegovina.
Omer Ć
OĆ
Ibrahimagić
a Department of Neurology , University Cinical Centre Tuzla, University of Tuzla , Tuzla , Bosnia and Herzegovina.
Dževdet
D
Smajlović
a Department of Neurology , University Cinical Centre Tuzla, University of Tuzla , Tuzla , Bosnia and Herzegovina.
Zikrija
Z
Dostović
a Department of Neurology , University Cinical Centre Tuzla, University of Tuzla , Tuzla , Bosnia and Herzegovina.
Amra
A
Iljazović
a Department of Neurology , University Cinical Centre Tuzla, University of Tuzla , Tuzla , Bosnia and Herzegovina.
Biljana
B
Kojić
a Department of Neurology , University Cinical Centre Tuzla, University of Tuzla , Tuzla , Bosnia and Herzegovina.
Lejla
L
Zonić
D002006:Brucellosis / Q000150:complications / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008875:Middle Aged; D012851:Sinus Thrombosis, Intracranial / Q000175:diagnosis* / Q000382:microbiology
Cerebral venous sinus thrombosis; Co-morbidity; Neurobrucellosis