Hypertriglyceridemic waist in type 1 diabetes patients: prevalence and related factors.
BACKGROUND
The hypertriglyceridemic waist has been linked to a higher number of cardiovascular risk factors and a greater probability of developing diabetes and cardiovascular disease. Around 50% of individuals with type 1 diabetes (T1D) are overweight or obese and triglyceridemia is associated with the onset of micro- and macrovascular complications.


METHODS
A cross-sectional study was conducted in men with T1D to assess the association between the prevalence of hypertriglyceridemic waist and cardiovascular risk factors and hypogonadism. Triglyceride levels + abdominal circumference taken together were stratified into quartiles to identify the hypertriglyceridemic waist phenotype.


RESULTS
One hundred and eighty-one male patients were included. An increased prevalence of hypogonadism and hypertension in parallel to increased triglyceride + waist circumference quartile was observed. Patients in the highest quartile had higher insulin resistance measured by estimated glucose disposal rate (eGDR 7.8±2.1 mg/kg-1.min-1 in 1st quartile vs. 5.8±1.8 mg/kg-1.min-1 in 4th quartile, P=0.000), insulin requirements, hip circumference, percentage of fat mass, glycosilated hemoglobin and total and LDL cholesterol as well as lower levels of total testosterone (27.24±9.3 nmol/L in 1st quartile vs. 17.4±8 nmol/L in 4th quartile, P=0.000) and HDL cholesterol. An inverse relationship was found between triglycerides + waist circumference and total testosterone levels (R=-0.367, P<0.0001).


CONCLUSIONS
The hypertriglyceridemic waist in men with T1D is associated with an atherogenic lipid profile, hypertension, worse metabolic diabetes control, increased insulin resistance and a higher prevalence of hypogonadism.
Department of Internal Medicine-Endocrinology and Nutrition, Centre d'Atenció Integral Dos de Maig, Barcelona, Spain.|Department of Medicine, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Spain.
Mercè
M
Fernández-Miró
Department of Medicine, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Spain - jChillaron@parcdesalutmar.cat; Department of Endocrinology and Nutrition, Hospital del Mar, Barcelona, Spain; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.
Juan J
JJ
Chillarón
Department of Endocrinology and Nutrition, Hospital de Sant Joan Despí Moisès Broggi, Sant Joan Despí, Spain.
Mercè
M
Albareda
Department of Medicine, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Spain.|Department of Medicine, Universitat Pompeu Fabra, Barcelona, Spain.
Sara
S
Fontserè
Department of Internal Medicine-Endocrinology and Nutrition, Centre d'Atenció Integral Dos de Maig, Barcelona, Spain.
Cristina
C
Colom
Department of Endocrinology and Nutrition, Hospital de Sant Joan Despí Moisès Broggi, Sant Joan Despí, Spain.
Lluís
L
Vila
Department of Medicine, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Spain; Department of Endocrinology and Nutrition, Hospital del Mar, Barcelona, Spain; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.
Juan
J
Pedro-Botet
Department of Medicine, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Spain; Department of Endocrinology and Nutrition, Hospital del Mar, Barcelona, Spain; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.
Juana A
JA
Flores LE-Roux
D000328:Adult; D003430:Cross-Sectional Studies; D003922:Diabetes Mellitus, Type 1 / Q000453:epidemiology* / Q000209:etiology*; D006801:Humans; D064250:Hypertriglyceridemic Waist / Q000453:epidemiology* / Q000209:etiology*; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology / Q000209:etiology; D008875:Middle Aged; D009765:Obesity / Q000150:complications; D015995:Prevalence; D012307:Risk Factors