Detection and differentiation of early acute and following age stages of myocardial infarction with quantitative post-mortem cardiac 1.5T MR.
Recently, quantitative MR sequences have started being used in post-mortem imaging. The goal of the present study was to evaluate if early acute and following age stages of myocardial infarction can be detected and discerned by quantitative 1.5T post-mortem cardiac magnetic resonance (PMCMR) based on quantitative T1, T2 and PD values. In 80 deceased individuals (25 female, 55 male), a cardiac MR quantification sequence was performed prior to cardiac dissection at autopsy in a prospective study. Focal myocardial signal alterations detected in synthetically generated MR images were MR quantified for their T1, T2 and PD values. The locations of signal alteration measurements in PMCMR were targeted at autopsy heart dissection and cardiac tissue specimens were taken for histologic examinations. Quantified signal alterations in PMCMR were correlated to their according histologic age stage of myocardial infarction. In PMCMR seventy-three focal myocardial signal alterations were detected in 49 of 80 investigated hearts. These signal alterations were diagnosed histologically as early acute (n=39), acute (n=14), subacute (n=10) and chronic (n=10) age stages of myocardial infarction. Statistical analysis revealed that based on their quantitative T1, T2 and PD values, a significant difference between all defined age groups of myocardial infarction can be determined. It can be concluded that quantitative 1.5T PMCMR quantification based on quantitative T1, T2 and PD values is feasible for characterization and differentiation of early acute and following age stages of myocardial infarction.
Institute of Forensic Medicine, University of Bern, Buehlstrasse 20, 3012 Bern, Switzerland.
Nicole
N
Schwendener
Institute of Forensic Medicine, University of Bern, Buehlstrasse 20, 3012 Bern, Switzerland.
Christian
C
Jackowski
Center for Medical Image Science and Visualization, CMIV, Linköping University, SE-58183 Linköping, Sweden; Department of Medical and Health Sciences, Linköping University, Linköping, Sweden.
Anders
A
Persson
Center for Medical Image Science and Visualization, CMIV, Linköping University, SE-58183 Linköping, Sweden; Department of Medical and Health Sciences, Linköping University, Linköping, Sweden.
Marcel J
MJ
Warntjes
Institute of Forensic Medicine, University of Bern, Buehlstrasse 20, 3012 Bern, Switzerland; Department of Diagnostic, Interventional and Pediatric Radiology, Hospital and University of Bern Inselspital, Freiburgstrasse 10, Bern CH-3010, Switzerland.
Frederick
F
Schuster
Institute of Forensic Medicine, University of Bern, Buehlstrasse 20, 3012 Bern, Switzerland.
Fabiano
F
Riva
Institute of Forensic Medicine, University of Bern, Buehlstrasse 20, 3012 Bern, Switzerland; Center for Medical Image Science and Visualization, CMIV, Linköping University, SE-58183 Linköping, Sweden; Department of Medical and Health Sciences, Linköping University, Linköping, Sweden. Electronic address: Wolf-Dieter.Zech@irm.unibe.ch.
Wolf-Dieter
WD
Zech
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001831:Body Temperature; D016022:Case-Control Studies; D004487:Edema / Q000473:pathology; D004802:Eosinophilia / Q000473:pathology; D005260:Female; D005347:Fibroblasts / Q000473:pathology; D049429:Forensic Pathology; D006098:Granulocytes / Q000473:pathology; D006470:Hemorrhage / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging* / Q000473:pathology*; D009206:Myocardium / Q000473:pathology*; D009336:Necrosis; D013997:Time Factors
Heart; Infarction age; Myocardial infarction; Post-mortem imaging; Quantitative post-mortem cardiac MR