Treatment with ustekinumab in a Spanish cohort of patients with psoriasis and psoriatic arthritis in daily clinical practice.
After approval of the use of ustekinumab for treatment of moderate to severe psoriasis, patients with psoriatic arthritis have treated with this drug in daily clinical practice. The aims of this study were to describe baseline characteristics and evolution of a cohort of patients with psoriasis and psoriatic arthritis treated with ustekinumab and to compare differences between patients who discontinued treatment and those who maintained. A retrospective multicenter observational study including patients who had received ustekinumab for a minimum of 3 months from 2009 to 2015 was performed. The baseline characteristics of the cohort of patients, the main indication for treatment, number and percentage of patients who maintained and discontinued treatment, reasons for discontinuation and differences between patients who discontinued and maintained ustekinumab were evaluated. Fifty-eight patients were included. The main indication was dermatological (72.4% of cases), and treatment with ustekinumab was maintained in most patients (62.1% of cases) with low discontinuation by side effects and rheumatological lack of efficacy. Discontinuation of ustekinumab was correlated with more number of obese patients, less presence of plaque psoriasis and more number of previous biological therapies. Ustekinumab demonstrated efficacy and safety in the management of patients with psoriasis and psoriatic arthritis in daily clinical practice in our cohort of patients.
Department of Rheumatology, Parc de Salut Mar, Barcelona, Spain.
Miriam
M
Almirall
Department of Rheumatology, Hospital de Bellvitge, Hospitalet de Llobregat, Spain.
Jesús
J
Rodriguez
Department of Rheumatology, Hospital Germans Trias i Pujol, Badalona, Spain.
Lourdes
L
Mateo
Department of Dermatology, Hospital Germans Trias i Pujol, Badalona, Spain.
José Manuel
JM
Carrascosa
Department of Dermatology, Hospital de Bellvitge, Hospitalet de Llobregat, Spain.
Jaime
J
Notario
Department of Dermatology, Parc de Salut Mar, Passeig Marítim 25-29, 08003, Barcelona, Spain. fgallardo@parcdesalutmar.cat.
Fernando
F
Gallardo
D000328:Adult; D000368:Aged; D015535:Arthritis, Psoriatic / Q000188:drug therapy*; D003879:Dermatologic Agents / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000188:drug therapy*; D012189:Retrospective Studies; D013030:Spain; D016896:Treatment Outcome; D000069549:Ustekinumab / Q000627:therapeutic use*
D003879:Dermatologic Agents; D000069549:Ustekinumab
Psoriasis; Psoriatic arthritis; Treatment; Ustekinumab