Eosinophilic esophagitis after congenital diaphragmatic hernia.
BACKGROUND
Eosinophilic esophagitis (EoE) is an increasingly diagnosed disease, especially in the western world. Although its pathogenesis remains poorly understood, there is strong evidence that the eosinophilic inflammation in EoE is primarily triggered by immune dysregulation secondary to allergic sensitization to dietary or aero-allergens. Recent studies have reported a higher prevalence of EoE in children with congenital gastrointestinal malformations, i.e. esophageal atresia and/or tracheoesophageal fistula.


METHODS
We present the case history of a 2-year-old boy who developed EoE in the aftermath of congenital diaphragmatic hernia (CDH) repair.


CONCLUSIONS
To the best of our knowledge, the following case report describes for the first time the possible association between CDH and EoE. Given the increasing reported prevalence of EoE in children with congenital gastrointestinal malformations, EoE should be rule out also in CDH survivors.
Department of Pediatrics, Foundation IRCCS Policlinico San Matteo, University of Pavia, Viale Golgi n. 19, 27100, Pavia, Italy. a.licari@smatteo.pv.it.
Amelia
http://orcid.org/0000-0002-1773-6482
A
Licari
Department of Pediatrics, Foundation IRCCS Policlinico San Matteo, University of Pavia, Viale Golgi n. 19, 27100, Pavia, Italy.
Riccardo
R
Castagnoli
Department of Pediatrics, Foundation IRCCS Policlinico San Matteo, University of Pavia, Viale Golgi n. 19, 27100, Pavia, Italy.
Gian Luigi
GL
Marseglia
D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001706:Biopsy; D003937:Diagnosis, Differential; D057765:Eosinophilic Esophagitis / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D000068298:Fluticasone / Q000627:therapeutic use; D005512:Food Hypersensitivity / Q000175:diagnosis; D065630:Hernias, Diaphragmatic, Congenital / Q000150:complications* / Q000601:surgery; D006801:Humans; D007223:Infant; D008297:Male; D012882:Skin Tests
D000893:Anti-Inflammatory Agents; D000068298:Fluticasone