Validation of the Korean Version of the Lewy Body Composite Risk Score (K-LBCRS).
The Lewy body composite risk score (LBCRS) is a useful clinical screening tool to help determine whether the dementia is related to Lewy body pathology. The purpose of this study is to verify reliability, validity, and diagnostic usefulness of Korean version of LBCRS (K-LBCRS). CDR-sum of boxes, Mini-Mental State Examination, and standardized scales related to cognition, mood, behavior, and motor function were administered to a total of 107 subjects, including 30 dementia with Lewy bodies (DLB), 54 Alzheimer's disease (AD), and 23 cognitively normal elderly people and their collateral informants. Internal consistency of the K-LBCRS was good with Cronbach's alpha of 0.85, and concurrent validity was also satisfactory, with K-LBCRS correlating highly with CDR-SB and other scales. The test-retest reliability was very high with a Pearson correlation coefficient of 0.97. The mean scores of K-LBCRS were significantly different among three groups, with DLB (6.2±2.4), AD (1.4±1.3), and controls (0.3±0.6). We identified a cut-off score of 3 as best to differentiate between DLB and AD, having AUC of 0.97 (95% CI 0.94-1.00), sensitivity 97%, specificity 83%, positive predictive value 76%, negative predictive value 98%, which is the same score suggested in the original study. This study shows K-LBCRS as a new useful screening tool for Korean DLB patients in clinical settings.
Department of Neurology, Konkuk University Medical Center, Seoul, Republic of Korea.
Hui Jin
HJ
Ryu
Department of Neurology, Konkuk University Medical Center, Seoul, Republic of Korea.
Minyoung
M
Kim
Department of Neurology, Konkuk University Medical Center, Seoul, Republic of Korea.
Yeonsil
Y
Moon
Department of Neurology, Konkuk University Medical Center, Seoul, Republic of Korea.
Yeji
Y
Choi
Department of Neurology, Seoul National University, Bundang Hospital, Bundang, Kyungi-do, Republic of Korea.
Jee-Young
JY
Han
Department of Integrated Medical Sciences, Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL, USA.
James E
JE
Galvin
Department of Neurology, Konkuk University Medical Center, Seoul, Republic of Korea.
Seol-Heui
SH
Han
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000175:diagnosis*; D000704:Analysis of Variance; D044466:Asian People; D005260:Female; D006801:Humans; D020961:Lewy Body Disease / Q000175:diagnosis*; D008297:Male; D000073216:Mental Status and Dementia Tests; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012372:ROC Curve; D015203:Reproducibility of Results; D012189:Retrospective Studies; D014175:Translating
Alzheimer’s disease; Korean version of the Lewy body composite risk score (K-LBCRS); Lewy bodies pathology; dementia with Lewy bodies; screening tool