PKA and Apicomplexan Parasite Diseases.
The cAMP-dependent protein kinase PKA is a well-characterized member of the serine-threonine protein AGC kinase family and is the effector kinase of cAMP signaling. As such, PKA is involved in the control of a wide variety of cellular processes including metabolism, cell growth, gene expression and apoptosis. cAMP-dependent PKA signaling pathways play important roles during infection and virulence of various pathogens. Since fluxes in cAMP are involved in multiple intracellular functions, a variety of different pathological infectious processes can be affected by PKA signaling pathways. Here, we highlight some features of cAMP-PKA signaling that are relevant toPlasmodium falciparum-infection of erythrocytes and present an update on AKAP targeting of PKA in PGE2 signaling via EP4 inTheileria annulata-infection of leukocytes and discuss cAMP-PKA signling in Toxoplasma.
Cochin Institute, Inserm U1016, CNRS UMR8104, Paris, France.
M
M
Haidar
Cochin Institute, Inserm U1016, CNRS UMR8104, Paris, France.
G
G
Ramdani
Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia, Athens, Georgia, USA.
E J
EJ
Kennedy
Cochin Institute, Inserm U1016, CNRS UMR8104, Paris, France.
G
G
Langsley
D054758:A Kinase Anchor Proteins / Q000378:metabolism; D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism*; D006801:Humans; D016778:Malaria, Falciparum / Q000201:enzymology* / Q000473:pathology; D010963:Plasmodium falciparum / Q000378:metabolism*; D015290:Second Messenger Systems; D016796:Theileria annulata / Q000378:metabolism*; D013801:Theileriasis / Q000201:enzymology* / Q000473:pathology
D054758:A Kinase Anchor Proteins; D000242:Cyclic AMP; D017868:Cyclic AMP-Dependent Protein Kinases