Metabolic Signaling Drives IFN-γ.
IFN-γ is a critical inflammatory cytokine that is closely regulated to cellular metabolic status and requires high rates of glycolysis. It has now been shown that a key mechanism to link these pathways is through maintenance of acetyl-CoA and epigenetic regulation of the IFNG locus.
Department of Pathology, Microbiology and Immunology, Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, TN 37232-2363, USA.
Peter J
PJ
Siska
Department of Pathology, Microbiology and Immunology, Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, TN 37232-2363, USA. Electronic address: jeff.rathmell@vanderbilt.edu.
Jeffrey C
JC
Rathmell
D016207:Cytokines; D044127:Epigenesis, Genetic; D006801:Humans; D007371:Interferon-gamma / Q000235:genetics*; D011401:Promoter Regions, Genetic; D015398:Signal Transduction
D016207:Cytokines; D007371:Interferon-gamma