The effect of pregnancy-specific β1-glycoprotein 1 on the transcription factor FOXP3 expression by immunocompetent cells.
The role of human pregnancy-specific β1-glycoprotein (PSG) in the regulation of expression of the transcription factor FOXP3 was studied. It is found that, under conditions of directed induction of phenotypic changes in CD4+lymphocytes to regulatory T cells (Treg), PSG at high concentrations (10 and 100 μg/mL) increased FOXP3 expression. The evaluation of the spontaneous expression level of FOXP3 mRNA showed that PSG (1 and 100 μg/mL) stimulated the expression of this factor in mononuclear cells and isolated CD4+lymphocytes. Thus, PSG stimulates FOXP3 expression in immunocompetent cells.
Institute of Ecology and Genetics of Microorganisms, Ural Branch, Russian Academy of Sciences, ul. Goleva 13, Perm, 614081, Russia.
S A
SA
Zamorina
Kant Baltic Federal University, ul. Botkina 3, Kaliningrad, Russia.
L S
LS
Litvinova
Kant Baltic Federal University, ul. Botkina 3, Kaliningrad, Russia.
K A
KA
Yurova
Kant Baltic Federal University, ul. Botkina 3, Kaliningrad, Russia.
N A
NA
Dunets
Kant Baltic Federal University, ul. Botkina 3, Kaliningrad, Russia.
O G
OG
Khaziakhmatova
Institute of Ecology and Genetics of Microorganisms, Ural Branch, Russian Academy of Sciences, ul. Goleva 13, Perm, 614081, Russia.
V P
VP
Timganova
Institute of Ecology and Genetics of Microorganisms, Ural Branch, Russian Academy of Sciences, ul. Goleva 13, Perm, 614081, Russia.
M S
MS
Bochkova
Institute of Ecology and Genetics of Microorganisms, Ural Branch, Russian Academy of Sciences, ul. Goleva 13, Perm, 614081, Russia.
P V
PV
Khramtsov
Institute of Ecology and Genetics of Microorganisms, Ural Branch, Russian Academy of Sciences, ul. Goleva 13, Perm, 614081, Russia. mraev@iegm.ru.|Yeltsin Ural Federal University, Yekaterinburg, Russia. mraev@iegm.ru.
M B
MB
Rayev
D015496:CD4-Positive T-Lymphocytes / Q000378:metabolism; D002478:Cells, Cultured; D005260:Female; D051858:Forkhead Transcription Factors / Q000378:metabolism*; D015870:Gene Expression; D006801:Humans; D011247:Pregnancy; D011268:Pregnancy-Specific beta 1-Glycoproteins / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D050378:T-Lymphocytes, Regulatory / Q000378:metabolism
C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors; D011268:Pregnancy-Specific beta 1-Glycoproteins; D012333:RNA, Messenger