In vitro transforming potential, intracellular signaling properties and sensitivity to a kinase inhibitor (sorafenib) of RET proto-oncogene variants Glu511Lys, Ser649Leu and Arg886Trp.
Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP) - Cancer BiologyPorto, Portugal.|Molecular Pathology ServicePortuguese Institute of Oncology of Coimbra FG, Coimbra, Portugal.|Department of PathologyMedical Faculty, University of Porto, Porto, Portugal.
Hugo
H
Prazeres
Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP) - Cancer BiologyPorto, Portugal.
Joana P
JP
Couto
Endocrinology ServicePortuguese Institute of Oncology of Coimbra FG, Coimbra, Portugal.
Fernando
F
Rodrigues
Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP) - Cancer BiologyPorto, Portugal.
João
J
Vinagre
Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP) - Cancer BiologyPorto, Portugal.
Joana
J
Torres
Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP) - Cancer BiologyPorto, Portugal.
Vitor
V
Trovisco
Molecular Pathology ServicePortuguese Institute of Oncology of Coimbra FG, Coimbra, Portugal.
Teresa C
TC
Martins
Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP) - Cancer BiologyPorto, Portugal.|Department of PathologyMedical Faculty, University of Porto, Porto, Portugal.
Manuel
M
Sobrinho-Simões
Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP) - Cancer BiologyPorto, Portugal psoares@ipatimup.pt.|Department of PathologyMedical Faculty, University of Porto, Porto, Portugal.
Paula
P
Soares