Oxidative trifluoromethylation and fluoroolefination of unactivated olefins.
Fluorine-containing organic compounds are gaining increasing importance in medicinal chemistry. Described herein is a mild and efficient method for the radical addition of olefins with TMSCF3and TMSCF2R (R = COOEt or CF3) to deliver various α-trifluoromethylated ketones and α-fluoroolefinated ketones.
Chemical Engineering College, Nanjing University of Science and Technology, 200 Xiao Ling Wei Street, Nanjing, Jiangsu, People's Republic of China. c.cai@njust.edu.cn.
Ye-Bin
YB
Wu
Chemical Engineering College, Nanjing University of Science and Technology, 200 Xiao Ling Wei Street, Nanjing, Jiangsu, People's Republic of China. c.cai@njust.edu.cn.
Guo-Ping
GP
Lu
Chemical Engineering College, Nanjing University of Science and Technology, 200 Xiao Ling Wei Street, Nanjing, Jiangsu, People's Republic of China. c.cai@njust.edu.cn.
Tao
T
Yuan
Chemical Engineering College, Nanjing University of Science and Technology, 200 Xiao Ling Wei Street, Nanjing, Jiangsu, People's Republic of China. c.cai@njust.edu.cn.
Zhu-Bing
ZB
Xu
Biotechnology and Pharmaceutical Engineering College, Nanjing Tech University, Nanjing 211816, People's Republic of China.
Li
L
Wan
Chemical Engineering College, Nanjing University of Science and Technology, 200 Xiao Ling Wei Street, Nanjing, Jiangsu, People's Republic of China. c.cai@njust.edu.cn and Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 20032, People's Republic of China.
Chun
C
Cai