Integrin αvβ3-Targeted C-Dot Nanocomposites as Multifunctional Agents for Cell Targeting and Photoacoustic Imaging of Superficial Malignant Tumors.
With a cocktail formulation of soybean milk as a green carbon source and TTDDA as a capping agent, integrin αvβ3-targeted C-dot nanocomposites (MB-CDs@NH-RGD) have been successfully fabricated via a facile microwaving protocol. Modification of the surface coating and RGD-conjugation endow their superior biocompatibility as well as highly specific targeting profile to αvβ3-overexpressed cell lines of MDA-MB231 and B16 as representative superficial malignant tumors. Meanwhile, the significant photothermal effect has been generated on irradiation of these targeted C-dot nanocomposites by a pulsed laser, which proved their eligibility for potential thermal ablation therapy. In vivo photoacoustic imaging using these C-dot nanocomposites as novel imaging probes verified their excellent targeting sensitivity and contrast enhancement. This exciting evidence implies a promising strategy to utilize them for multifunctional nanotheranostic purposes in combination with precision diagnosis and photothermal treatment against superficial malignant tumors.
Wenzhou Institute of Biomaterials and Engineering, Wenzhou Medical University , Wenzhou 325001, Zhejiang China.|Wenzhou Institute of Biomaterials and Engineering, Chinese Academy of Sciences , Wenzhou 325011, Zhejiang China.
Zhe
Z
Liu
Wenzhou Institute of Biomaterials and Engineering, Wenzhou Medical University , Wenzhou 325001, Zhejiang China.|Wenzhou Institute of Biomaterials and Engineering, Chinese Academy of Sciences , Wenzhou 325011, Zhejiang China.
Waner
W
Chen
Wenzhou Institute of Biomaterials and Engineering, Wenzhou Medical University , Wenzhou 325001, Zhejiang China.|Wenzhou Institute of Biomaterials and Engineering, Chinese Academy of Sciences , Wenzhou 325011, Zhejiang China.
Yihong
Y
Li
Wenzhou Institute of Biomaterials and Engineering, Wenzhou Medical University , Wenzhou 325001, Zhejiang China.|Wenzhou Institute of Biomaterials and Engineering, Chinese Academy of Sciences , Wenzhou 325011, Zhejiang China.
Qien
Q
Xu
D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy; D002244:Carbon / Q000737:chemistry* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D005260:Female; D006801:Humans; D039302:Integrin alphaVbeta3 / Q000032:analysis*; D008325:Mammary Neoplasms, Experimental / Q000000981:diagnostic imaging / Q000188:drug therapy; D008545:Melanoma / Q000000981:diagnostic imaging* / Q000188:drug therapy; D008546:Melanoma, Experimental / Q000000981:diagnostic imaging / Q000188:drug therapy; D018613:Microscopy, Confocal; D053761:Nanocomposites / Q000737:chemistry*; D009842:Oligopeptides / Q000737:chemistry* / Q000494:pharmacology; D010316:Particle Size; D061088:Photoacoustic Techniques; D045663:Quantum Dots; D013499:Surface Properties
D039302:Integrin alphaVbeta3; D009842:Oligopeptides; D002244:Carbon; C047981:arginyl-glycyl-aspartic acid