Novel N-Doped Carbon Dots/β-Cyclodextrin Nanocomposites for Enantioselective Recognition of Tryptophan Enantiomers.
Based on N-doped carbon dots/β-cyclodextrin nanocomposites modified glassy carbon electrodes (N-CDs/β-CD/GCE), an effective electrochemical sensor for enantioselective recognition of tryptophan (Trp) enantiomers was developed by differential pulse voltammograms (DPVs). Fluorescent N-CDs were synthesized through a hydrothermal method and characterized by spectroscopic approaches. The N-CDs/β-CD nanocomposites were efficiently electrodeposited on the surface of GCE through C-N bond formation between N-CDs and electrode. The obtained N-CDs/β-CD/GCE was characterized by multispectroscopic and electrochemical methods. Such N-CDs/β-CD/GCE generated a significantly lower Ip and more negative Ep in the presence of l-Trp in DPVs, which was used for the enantioselective recognition of Trp enantiomers. The N-CDs/β-CD nanocomposites showed different binding constants for tryptophan enantiomers, and they further selectively bonded with l-Trp to form inclusion complexes. This N-CDs/β-CD/GCE combined advantages of N-CDs with strong C-N binding ability and β-CD with specific recognition of Trp enantiomers to fabricate a novel sensing platform for enantioselective recognition of Trp enantiomers. This strategy provided the possibility of using a nanostructured sensor to discriminate the chiral molecules in bio-electroanalytical applications.
College of Chemistry and Materials Science, Guangxi Teachers Education University, Nanning 530001, China. qi.xiao@whu.edu.cn.
Qi
Q
Xiao
College of Chemistry and Materials Science, Guangxi Teachers Education University, Nanning 530001, China. shuangyan_lu@163.com.
Shuangyan
S
Lu
College of Chemistry and Materials Science, Guangxi Teachers Education University, Nanning 530001, China. huangcs@gxtc.edu.cn.
Chusheng
C
Huang
College of Chemistry and Materials Science, Guangxi Teachers Education University, Nanning 530001, China. suwmail@163.com.
Wei
W
Su
College of Chemistry and Materials Science, Guangxi Teachers Education University, Nanning 530001, China. huangs@whu.edu.cn.
Shan
S
Huang
D002244:Carbon / Q000737:chemistry; D053761:Nanocomposites / Q000737:chemistry*; D013237:Stereoisomerism; D014364:Tryptophan / Q000737:chemistry*; D047392:beta-Cyclodextrins / Q000737:chemistry
D047392:beta-Cyclodextrins; D002244:Carbon; D014364:Tryptophan
N-doped carbon dots; differential pulse voltammetry; enantioselective recognition; tryptophan enantiomers; β-cyclodextrin