The importance of being (slightly) modified: The role of rRNA editing on gene expression control and its connections with cancer.
In human ribosomal RNAs, over 200 residues are modified by specific, RNA-driven enzymatic complexes or stand-alone, RNA-independent enzymes. In most cases, modification sites are placed in specific positions within important functional areas of the ribosome. Some evidence indicates that the altered control in ribosomal RNA modifications may affect ribosomal function during mRNA translation. Here we provide an overview of the connections linking ribosomal RNA modifications to ribosome function, and suggest how aberrant modifications may affect the control of the expression of key cancer genes, thus contributing to tumor development. In addition, the future perspectives in this field are discussed.
Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Via Massarenti 9, 40138 Bologna, Italy. Electronic address: marianna.penzo@unibo.it.
Marianna
M
Penzo
Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Via Massarenti 9, 40138 Bologna, Italy.
Alice
A
Galbiati
Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Via Massarenti 9, 40138 Bologna, Italy.
Davide
D
Treré
Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Via Massarenti 9, 40138 Bologna, Italy. Electronic address: lorenzo.montanaro@unibo.it.
Lorenzo
L
Montanaro
D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009369:Neoplasms / Q000209:etiology* / Q000235:genetics; D017393:RNA Editing; D012335:RNA, Ribosomal / Q000235:genetics*
D012335:RNA, Ribosomal
Cancer; Methylation; Pseudouridylation; Ribosome; mRNA translation; rRNA modifications