Immune modules shared by innate lymphoid cells and T cells.
In recent years, innate lymphoid cells (ILCs) have emerged as innate correlates to T cells. The similarities between ILCs and T cells indicate that lymphocytes of fundamentally distinct lineages can share core "immune modules" that encompass transcriptional circuitry and effector functions while using nonredundant complementary mechanisms of pattern recognition to enact these functions. We review modules currently recognized to be shared between ILCs and T cells.
Department of Pathology & Immunology, Washington University School of Medicine, St Louis, Mo.
Michelle L
ML
Robinette
Department of Pathology & Immunology, Washington University School of Medicine, St Louis, Mo. Electronic address: mcolonna@pathology.wustl.edu.
Marco
M
Colonna
D000818:Animals; D001424:Bacterial Infections / Q000276:immunology; D006373:Helminthiasis / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D008214:Lymphocytes / Q000276:immunology*; D009181:Mycoses / Q000276:immunology; D014777:Virus Diseases / Q000276:immunology
Innate lymphoid cell; T cell; adaptive; innate; lymphocyte