Daidzein and its Effects on Brain.
Among naturally occurring isoflavones, soy isoflavones are an important class with various biological activities. Due to their phytoestrogenic structure, their effects on the brain are profound thus making the neurobiological effects of these compounds an active area of research. One such compound is daidzein, which has been reported to affect various neurobiological regulatory mechanisms such as behavior, cognition, growth, development and reproduction. These effects are mainly elicited through the interaction of daidzein with different signaling molecules and receptors, thereby offering neuroprotection. In addition, daidzein has also been reported to possess activities against various neuropathological conditions mainly by its interaction with the cerebrovascular system. This review focuses on providing a comprehensive account on the bioavailability and metabolism of daidzein in vivo, and discusses its activities and mechanisms of action in detail, in both physiological and pathological conditions. In addition, the effects of daidzein on other disorders have also been examined briefly in this article.
Neurobiology Laboratory, Atta-ur-Rahman School of Applied Biosciences, National University of Sciences and Technology, Sector H-12, Islamabad - 44000, Pakistan.
Touqeer
T
Ahmed
Neurobiology Laboratory, Department of Healthcare Biotechnology, Atta-ur-Rahman School of Applied Biosciences, National University of Sciences and Technology, Sector H-12, Islamabad - 44000, Pakistan.
Sana
S
Javed
Neurobiology Laboratory, Department of Healthcare Biotechnology, Atta-ur-Rahman School of Applied Biosciences, National University of Sciences and Technology, Sector H-12, Islamabad - 44000, Pakistan.
Ameema
A
Tariq
Department of Pharmacology and Pharmacodynamics, Medical University of Lublin, 4a Chodzki Str., 20- 093 Lublin, Poland.
Barbara
B
Budzyńska
Geriatric Unit & Laboratory of Gerontology and Geriatrics, Department of Medical Sciences, IRCCS "Casa Sollievo della Sofferenza", San Giovanni Rotondo, Foggia, Italy.
Grazia
G
D'Onofrio
Department of Drug Sciences, Medicinal Chemistry and Pharmaceutical Technology Section, Pavia University, Via Taramelli 12, 27100 Pavia, Italy.
Maria
M
Daglia
Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Seyed Fazel
SF
Nabavi
Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, P.O. Box 19395-5487, Iran.
Seyed Mohammad
SM
Nabavi
D000818:Animals; D001519:Behavior / Q000187:drug effects; D001921:Brain / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D003071:Cognition / Q000187:drug effects; D006801:Humans; D007529:Isoflavones / Q000378:metabolism / Q000493:pharmacokinetics / Q000494:pharmacology*; D012098:Reproduction / Q000187:drug effects
D007529:Isoflavones; C004742:daidzein
Daidzein; cellular pathways; genistein; hormones; neuroprotection