Clinical and molecular cytogenetic studies in ten patients with hematological malignancies characterized by t(20;21)(q11;q11) resulted from del(20q).
This study reports 10 patients with hematological malignances with t(20;21)(q11;q11) resulting from del(20q) (for example, der(20)del(20)(q11q13)t(20;21)(q11;q11) and der(21)t(20;21)(q11;q11)) and described their clinical features and the possible prognostic significance of this abnormality. The t(20;21)(q11;q11) was a rare but recurrent abnormality secondary to del(20q) besides i(20q-). The frequency of der(20)del(20)(q11q13)t(20;21)(q11;q11) among our patients with del(20q) was 2.4%. It was considered that the 20q deletion preceded translocation with chromosome 21. This abnormality is often cryptic, occurs predominantly in older men and is observed most often in myelodysplastic syndromes. Patients with this abnormality have an unfavorable prognosis, similar to patients with i(20q-). The molecular consequences of der(20)del(20)(q11q13)t(20;21)(q11;q11) may be different from patients with i(20q-). To the best of our knowledge this is the largest dataset published to date.
Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006, China.
Chunxiao
C
Wu
Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006, China.
Jun
J
Zhang
Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006, China.
Shuxiao
S
Bai
Changshu No.2 People's Hospital, China.
Jianxin
J
Yao
Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006, China.
Huiying
H
Qiu
Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006, China.
Yongquan
Y
Xue
Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006, China.
Suning
S
Chen
Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006, China.
Yafang
Y
Wu
Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006, China.
Juan
J
Shen
Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006, China. Electronic address: Jinlanpan@126.com.
Jinlan
J
Pan
D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor; D002872:Chromosome Deletion; D002890:Chromosomes, Human, Pair 20 / Q000235:genetics*; D002891:Chromosomes, Human, Pair 21 / Q000235:genetics*; D005260:Female; D005500:Follow-Up Studies; D019337:Hematologic Neoplasms / Q000235:genetics* / Q000473:pathology; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D014178:Translocation, Genetic / Q000235:genetics*
D014408:Biomarkers, Tumor
Myeloid disease; del(20q); fluorescence in situ hybridization; microarray CGH analysis; t(20;21)(q11;q11)