A Disintegrin and Metalloprotease 17 in the Cardiovascular and Central Nervous Systems.
ADAM17 is a metalloprotease and disintegrin that lodges in the plasmatic membrane of several cell types and is able to cleave a wide variety of cell surface proteins. It is somatically expressed in mammalian organisms and its proteolytic action influences several physiological and pathological processes. This review focuses on the structure of ADAM17, its signaling in the cardiovascular system and its participation in certain disorders involving the heart, blood vessels, and neural regulation of autonomic and cardiovascular modulation.
Department of Pharmacology and Experimental Therapeutics and Cardiovascular Center of Excellence, Louisiana State University Health Sciences Center New Orleans, LA, USA.
Jiaxi
J
Xu
Department of Pharmacology and Experimental Therapeutics and Cardiovascular Center of Excellence, Louisiana State University Health Sciences Center New Orleans, LA, USA.
Snigdha
S
Mukerjee
Centro de Biotecnologia, Universidade Federal da Paraíba João Pessoa, Brazil.
Cristiane R A
CR
Silva-Alves
Centro de Biotecnologia, Universidade Federal da Paraíba João Pessoa, Brazil.
Alynne
A
Carvalho-Galvão
Centro de Biotecnologia, Universidade Federal da Paraíba João Pessoa, Brazil.
Josiane C
JC
Cruz
Centro de Ciências da Saúde, Universidade Federal da Paraíba João Pessoa, Brazil.
Camille M
CM
Balarini
Centro de Biotecnologia, Universidade Federal da Paraíba João Pessoa, Brazil.
Valdir A
VA
Braga
Department of Pharmacology and Experimental Therapeutics and Cardiovascular Center of Excellence, Louisiana State University Health Sciences Center New Orleans, LA, USA.
Eric
E
Lazartigues
Centro de Biotecnologia, Universidade Federal da Paraíba João Pessoa, Brazil.
Maria S
MS
França-Silva
ACE2; EGFR; TACE; TNFα; atherosclerosis; hypertension; shedding