Antibiotics Modulate the Ability of Neutrophils to Release Neutrophil Extracellular Traps.
Antibiotics directly inhibit the growth and kill microorganisms, and many of them have immunomodulatory properties. We investigated the influence of cefotaxime and gentamicin on the release of neutrophil extracellular traps (NETs) - recently described strategy employed by neutrophils to fight infections. We found that gentamicin inhibits NETs release by human neutrophils, while cefotaxime did not have any impact on this process. The information that antibiotics can modulate NETs release, can be useful in the therapy of infectious diseases in patients suffering from NET-related diseases.
Department of Laboratory Diagnostics and Clinical Immunology of Developmental Age, Warsaw Medical University, 63A Zwirki i Wigury Street, 02-091, Warsaw, Poland. aneta.manda-handzlik@wum.edu.pl.|Postgraduate School of Molecular Medicine, Warsaw Medical University, 63A Zwirki i Wigury Street, 02-091, Warsaw, Poland. aneta.manda-handzlik@wum.edu.pl.
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Manda-Handzlik
Student Scientific Group at the Department of Laboratory Diagnostics and Clinical Immunology of Developmental Age, Warsaw Medical University, 63A Zwirki i Wigury Street, 02-091, Warsaw, Poland.
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Bystrzycka
Student Scientific Group at the Department of Laboratory Diagnostics and Clinical Immunology of Developmental Age, Warsaw Medical University, 63A Zwirki i Wigury Street, 02-091, Warsaw, Poland.
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Sieczkowska
Department of Laboratory Diagnostics and Clinical Immunology of Developmental Age, Warsaw Medical University, 63A Zwirki i Wigury Street, 02-091, Warsaw, Poland.
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Demkow
Department of Laboratory Diagnostics and Clinical Immunology of Developmental Age, Warsaw Medical University, 63A Zwirki i Wigury Street, 02-091, Warsaw, Poland.
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Ciepiela
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002439:Cefotaxime / Q000494:pharmacology; D065206:Extracellular Traps / Q000187:drug effects*; D005839:Gentamicins / Q000494:pharmacology; D006801:Humans; D007155:Immunologic Factors / Q000494:pharmacology; D018375:Neutrophil Activation / Q000187:drug effects; D009504:Neutrophils / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D007155:Immunologic Factors; D002439:Cefotaxime
Cefotaxime; Gentamicin; Granulocytes; NETs; Phagocytosis