Oil-in-water nanoemulsions are suitable for carrying hydrophobic compounds: Indomethacin as a model of anti-inflammatory drug.
Oil-in-water nanoemulsions are increasingly being used as delivery systems for encapsulating lipophilic components in functional food, personal care and pharmaceutical products. In the current study, we developed a multimodal platform to carry hydrophobic indomethacin or magnetic nanoparticles, or both. As a consequence, this platform has great potential for therapeutic or imaging purposes. By optimizing the system composition and homogenization conditions, a nanoemulsion with a mean droplet diameter of about 200nm and a low polydispersity index (<0.2) was formed. The plain nanoemulsion was shown to be innocuous in cellular studies and did not present acute toxicity (observed in a rat model). More interesting was the finding that nanoemulsions loaded with indomethacin presented a significantly different anti-inflammatory than the free drug.
Department of Pharmacy, Pharmaceutical Technology and Physical Chemsitry, Faculty of Pharmacy and Food Sciences, Universitat de Barcelona, Avda. Joan XXIII, 17-31, 08028, Barcelona, Catalonia, Spain.
Björn
B
Kwasigroch
Department of Pharmacy, Pharmaceutical Technology and Physical Chemsitry, Faculty of Pharmacy and Food Sciences, Universitat de Barcelona, Avda. Joan XXIII, 17-31, 08028, Barcelona, Catalonia, Spain; Insitute of Nanoscience and Nanotechnology (IN2UB), Faculty of Pharmacy and Food Sciences, Universitat de Barcelona, Avda. Joan XXIII, 17-31, 08028, Barcelona, Catalonia, Spain.
Elvira
E
Escribano
Departament Biochemistry and Physiology, Faculty of Pharmacy and Food Sciences, Universitat de Barcelona, Avda. Joan XXIII, 17-31, 08028, Barcelona, Catalonia, Spain; Insitute of Nanoscience and Nanotechnology (IN2UB), Faculty of Pharmacy and Food Sciences, Universitat de Barcelona, Avda. Joan XXIII, 17-31, 08028, Barcelona, Catalonia, Spain.
María Del Carmen
MDC
Morán
Departament Biochemistry and Physiology, Faculty of Pharmacy and Food Sciences, Universitat de Barcelona, Avda. Joan XXIII, 17-31, 08028, Barcelona, Catalonia, Spain.
Josep
J
Queralt
Department of Pharmacy, Pharmaceutical Technology and Physical Chemsitry, Faculty of Pharmacy and Food Sciences, Universitat de Barcelona, Avda. Joan XXIII, 17-31, 08028, Barcelona, Catalonia, Spain; Insitute of Nanoscience and Nanotechnology (IN2UB), Faculty of Pharmacy and Food Sciences, Universitat de Barcelona, Avda. Joan XXIII, 17-31, 08028, Barcelona, Catalonia, Spain.
Maria Antònia
MA
Busquets
Department of Pharmacy, Pharmaceutical Technology and Physical Chemsitry, Faculty of Pharmacy and Food Sciences, Universitat de Barcelona, Avda. Joan XXIII, 17-31, 08028, Barcelona, Catalonia, Spain; Insitute of Nanoscience and Nanotechnology (IN2UB), Faculty of Pharmacy and Food Sciences, Universitat de Barcelona, Avda. Joan XXIII, 17-31, 08028, Barcelona, Catalonia, Spain. Electronic address: joanestelrich@ub.edu.
Joan
J
Estelrich
D016475:3T3 Cells; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry*; D002460:Cell Line; D045744:Cell Line, Tumor; D002626:Chemistry, Pharmaceutical / Q000379:methods; D016503:Drug Delivery Systems / Q000379:methods; D004655:Emulsions / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D007213:Indomethacin / Q000737:chemistry*; D008297:Male; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry*; D009821:Oils / Q000737:chemistry*; D010316:Particle Size; D051381:Rats; D017207:Rats, Sprague-Dawley; D014867:Water / Q000737:chemistry*
D000893:Anti-Inflammatory Agents; D004655:Emulsions; D009821:Oils; D014867:Water; D007213:Indomethacin
Acute toxicity; Anti-inflammation; Cell viability; Indomethacin; Nanoemulsion