The Epigenome and Cancer Stem Cell Fate: Connected by a Linker Histone Variant.
The molecular features underlying tumor heterogeneity and the role of chromatin components in regulating cell fate within tumors are not well understood. Recently in Science, Torres et al. (2016) showed that the linker histone variant H1.0 functions as a chromatin switch that determines self-renewal versus differentiation decisions in cancer stem cells.
Institut Curie, PSL Research University, CNRS, UMR3664, Equipe Labellisée Ligue contre le Cancer, F-75005 Paris, France; Sorbonne Universités, UPMC Univ Paris 06, CNRS, UMR3664, F-75005 Paris, France.
Guillermo A
GA
Orsi
Institut Curie, PSL Research University, CNRS, UMR3664, Equipe Labellisée Ligue contre le Cancer, F-75005 Paris, France; Sorbonne Universités, UPMC Univ Paris 06, CNRS, UMR3664, F-75005 Paris, France.
Monica
M
Naughtin
Institut Curie, PSL Research University, CNRS, UMR3664, Equipe Labellisée Ligue contre le Cancer, F-75005 Paris, France; Sorbonne Universités, UPMC Univ Paris 06, CNRS, UMR3664, F-75005 Paris, France. Electronic address: genevieve.almouzni@curie.fr.
Geneviève
G
Almouzni
D002454:Cell Differentiation; D002843:Chromatin; D006657:Histones / Q000235:genetics*; D006801:Humans; D014411:Neoplastic Stem Cells
D002843:Chromatin; D006657:Histones