Generalized pustular psoriasis induced by systemic steroid dose reduction.
Generalized pustular psoriasis, or psoriasis of von Zumbusch, is an acute and severe clinical form of psoriasis, which usually occurs in patients with psoriasis undergoing aggravating factors. In this work, we report the case of a female patient, 70 years old, who developed generalized pustular psoriasis symptoms while reducing the dose of oral corticosteroids, improperly introduced for the treatment of alleged acute generalized exanthematous pustulosis. The differential diagnosis of generalized pustular psoriasis should be made with other pustular dermatoses, such as subcorneal pustulosis, IgA pemphigus and especially with acute generalized exanthematous pustulosis. Personal history of psoriasis and histopathological findings with psoriasiform changes and subcorneal pustule favored the diagnosis. She was treated with acitretin 30 mg / day, progressing to complete regression of the lesions.
Fundação Alfredo da Matta (Fuam) - Manaus (AM), Brazil.
Danielle Cristine
DC
Westphal
Fundação Alfredo da Matta (Fuam) - Manaus (AM), Brazil.
Antonio Pedro Mendes
AP
Schettini
Fundação Alfredo da Matta (Fuam) - Manaus (AM), Brazil.
Petra Pereira de
PP
Souza
Fundação Alfredo da Matta (Fuam) - Manaus (AM), Brazil.
Jessica
J
Castiel
Fundação Alfredo da Matta (Fuam) - Manaus (AM), Brazil.
Carlos Alberto
CA
Chirano
Fundação Alfredo da Matta (Fuam) - Manaus (AM), Brazil.|Universidade do Estado do Amazonas (UEA) - Manaus (AM), Brazil.
Mônica
M
Santos
D017255:Acitretin / Q000627:therapeutic use; D000368:Aged; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007641:Keratolytic Agents / Q000627:therapeutic use; D011241:Prednisone / Q000008:administration & dosage*; D011565:Psoriasis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D013256:Steroids / Q000008:administration & dosage*
D007641:Keratolytic Agents; D013256:Steroids; D017255:Acitretin; D011241:Prednisone