Prolonged Isotretinoin in Ultra High-Risk Neuroblastoma.
Patients with high-risk neuroblastoma remain a therapeutic challenge with significant numbers of patients failing to respond sufficiently to initial therapy. These patients with poor response to induction are considered as ultra high-risk and are in need of novel treatment strategies. Isotretinoin is part of the standard of care treatment for patients with high-risk disease who undergo high-dose chemotherapy with autologous stem cell rescue although some have questioned the optimal administration schedule. Prolonged use of isotretinoin was well tolerated and may have contributed to long-term survival in a group of patients with ultra high-risk neuroblastoma.
*Aflac Cancer Center, Division of Pediatric Hematology/Oncology, Children's Healthcare of Atlanta †Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA ‡Division of Pediatric Hematology/Oncology, Monroe Carell Jr Children's Hospital, Vanderbilt University, Nashville, TN.
Thomas
T
Cash
Adina
A
Alazraki
Muna
M
Qayed
Howard M
HM
Katzenstein
D019797:3-Iodobenzylguanidine / Q000627:therapeutic use; D000310:Adrenal Gland Neoplasms / Q000188:drug therapy* / Q000628:therapy; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000556:secondary; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D004334:Drug Administration Schedule; D017809:Fatal Outcome; D005260:Female; D018305:Ganglioneuroblastoma / Q000188:drug therapy* / Q000601:surgery; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D015474:Isotretinoin / Q000008:administration & dosage* / Q000627:therapeutic use; D060046:Maintenance Chemotherapy / Q000379:methods*; D008297:Male; D009447:Neuroblastoma / Q000188:drug therapy* / Q000556:secondary / Q000628:therapy; D012074:Remission Induction; D012306:Risk; D014182:Transplantation, Autologous
D000970:Antineoplastic Agents; D019797:3-Iodobenzylguanidine; D015474:Isotretinoin