Blood-Based Oxidative Stress Markers and Cognitive Performance in Early Old Age: The HAPIEE Study.
Oxidative stress is involved in Alzheimer disease pathology, but its impact on cognitive function in community-dwelling older adults remains unknown. We estimated associations between serum oxidative stress markers and cognitive function in early old age.



Subjects aged 45-69 years recruited in urban centers in Central and Eastern Europe had memory, verbal fluency, and processing speed assessed at baseline (2002-2005) and 3 years later. Derivatives of reactive oxygen metabolites (d-ROMs), biological antioxidant potential (BAP), and total thiol levels (TTLs) were measured at baseline in a subsample. Linear regression was used to estimate associations of biomarkers with cognitive test scores cross-sectionally (n = 4,304) and prospectively (n = 2,882).



Increased d-ROM levels were inversely associated with global cognition and verbal fluency cross-sectionally and in prospective analysis; observed effects corresponded to 3-4 years' higher age. TTL was inconsistently associated with memory. BAP was not related to cognitive function.



This study found modest evidence for a relationship between serum d-ROMs and cognitive function in a population sample of older adults.
Department of Epidemiology and Public Health, University College London, London, UK.
Pia
P
Horvat
Ruzena
R
Kubinova
Andrzej
A
Pajak
Abdonas
A
Tamosiunas
Ben
B
Schöttker
Hynek
H
Pikhart
Anne
A
Peasey
Magdalena
M
Kozela
Eugene
E
Jansen
Archana
A
Singh-Manoux
Martin
M
Bobak
D000368:Aged; D000975:Antioxidants / Q000378:metabolism*; D015415:Biomarkers / Q000097:blood; D003071:Cognition; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008568:Memory; D008875:Middle Aged; D009483:Neuropsychological Tests; D018384:Oxidative Stress; D011446:Prospective Studies; D017382:Reactive Oxygen Species / Q000097:blood*; D013438:Sulfhydryl Compounds / Q000097:blood*
D000975:Antioxidants; D015415:Biomarkers; D017382:Reactive Oxygen Species; D013438:Sulfhydryl Compounds