Medical Imaging Informatics.
Imaging is one of the most important sources of clinically observable evidence that provides broad coverage, can provide insight on low-level scale properties, is noninvasive, has few side effects, and can be performed frequently. Thus, imaging data provides a viable observable that can facilitate the instantiation of a theoretical understanding of a disease for a particular patient context by connecting imaging findings to other biologic parameters in the model (e.g., genetic, molecular, symptoms, and patient survival). These connections can help inform their possible states and/or provide further coherent evidence. The field of radiomics is particularly dedicated to this task and seeks to extract quantifiable measures wherever possible. Example properties of investigation include genotype characterization, histopathology parameters, metabolite concentrations, vascular proliferation, necrosis, cellularity, and oxygenation. Important issues within the field include: signal calibration, spatial calibration, preprocessing methods (e.g., noise suppression, motion correction, and field bias correction), segmentation of target anatomic/pathologic entities, extraction of computed features, and inferencing methods connecting imaging features to biological states.
Department of Radiological Sciences, University of California, Los Angeles, CA, USA.
William
W
Hsu
Department of Radiological Sciences, University of California, Los Angeles, CA, USA.
Suzie
S
El-Saden
Department of Radiological Sciences, University of California, Los Angeles, CA, USA. rtaira@ucla.edu.
Ricky K
RK
Taira
D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000235:genetics / Q000473:pathology; D015870:Gene Expression; D060005:Genotyping Techniques; D005909:Glioblastoma / Q000000981:diagnostic imaging* / Q000235:genetics / Q000473:pathology; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008491:Medical Informatics Applications; D009336:Necrosis / Q000000981:diagnostic imaging* / Q000235:genetics / Q000473:pathology; D009363:Neoplasm Proteins / Q000235:genetics / Q000378:metabolism; D009389:Neovascularization, Pathologic / Q000000981:diagnostic imaging* / Q000235:genetics / Q000473:pathology; D057285:Precision Medicine / Q000379:methods*
D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins
Glioblastoma multiforme; Imaging informatics; Imaging standards; Magnetic resonance imaging; Quantitative imaging; Radiogenomics; Radiomics