All Roads Lead to the miRNome: miRNAs Have a Central Role in the Molecular Pathophysiology of Psychiatric Disorders.
Current treatment strategies for psychiatric disorders remain inadequate. Impeding development of novel therapeutics is our incomplete knowledge of the molecular pathophysiology underlying these disorders. Changes to miRNA function and expression are increasingly being associated with pathological behavioral states. Furthermore, the prospect of using of miRNA expression profiles (the miRNome) as objective psychiatric diagnosis tools is gaining traction. In this review, we focus on recent findings surrounding the link between miRNA function and psychiatric disorders, and outline some of the key challenges that will need to be overcome if the therapeutic potential of these molecular effectors is to be fully realized.
Department of Neuroscience, Icahn School of Medicine, Mount Sinai Hospital, NY, USA. Electronic address: richard.oconnor@mssm.edu.
Richard M
RM
O'Connor
Department of Anatomy and Neuroscience, University College Cork, Ireland.
Anand
A
Gururajan
Department of Psychiatry, University College Cork, Ireland; APC Microbiome Institute, University College Cork, Ireland.
Timothy G
TG
Dinan
Department of Neuroscience, Icahn School of Medicine, Mount Sinai Hospital, NY, USA.
Paul J
PJ
Kenny
Department of Anatomy and Neuroscience, University College Cork, Ireland; APC Microbiome Institute, University College Cork, Ireland.
John F
JF
Cryan
D000818:Animals; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D006801:Humans; D001523:Mental Disorders / Q000235:genetics / Q000503:physiopathology* / Q000628:therapy; D035683:MicroRNAs / Q000235:genetics*
D035683:MicroRNAs