Receptor for Advanced Glycation End Products Regulates Leukotriene B4Receptor 1 Signaling.
Leukotriene B4receptor 1 (BLT1), a high-affinity G protein-coupled receptor (GPCR) for leukotriene B4(LTB4), plays important roles in inflammatory and immune reactions. Although the LTB4-BLT1 axis is known to promote inflammation, the binding proteins that modulate LTB4-BLT1 signaling have not been identified. Recently, we discovered that receptor for advanced glycation end products (RAGE) interacts with BLT1 and modulates LTB4-BLT1 signaling. We propose RAGE as a new class of GPCR modulator and a new target of future GPCR studies.
1 Department of Biochemistry, Juntendo University School of Medicine , Tokyo, Japan .
Takako
T
Ichiki
1 Department of Biochemistry, Juntendo University School of Medicine , Tokyo, Japan .|2 Priority Organization for Innovation and Excellence, Program for Leading Graduate Schools, "Health Life Science: Interdisciplinary and Glocal Oriented (HIGO) Program," Kumamoto University , Kumamoto, Japan .
Tomoaki
T
Koga
1 Department of Biochemistry, Juntendo University School of Medicine , Tokyo, Japan .
Takehiko
T
Yokomizo
D005786:Gene Expression Regulation; D006801:Humans; D007249:Inflammation; D007963:Leukocytes, Mononuclear / Q000276:immunology* / Q000473:pathology; D007975:Leukotriene B4 / Q000276:immunology / Q000378:metabolism*; D020935:MAP Kinase Signaling System / Q000235:genetics / Q000276:immunology; D008264:Macrophages / Q000276:immunology* / Q000473:pathology; D019950:Mitogen-Activated Protein Kinase 1 / Q000235:genetics / Q000276:immunology; D048052:Mitogen-Activated Protein Kinase 3 / Q000235:genetics / Q000276:immunology; D016328:NF-kappa B / Q000235:genetics / Q000276:immunology; D010766:Phosphorylation; D000067759:Receptor for Advanced Glycation End Products / Q000235:genetics* / Q000276:immunology; D018102:Receptors, Leukotriene B4 / Q000235:genetics* / Q000276:immunology
C000593871:AGER protein, human; C513240:LTB4R protein, human; D016328:NF-kappa B; D000067759:Receptor for Advanced Glycation End Products; D018102:Receptors, Leukotriene B4; D007975:Leukotriene B4; C535150:MAPK1 protein, human; D019950:Mitogen-Activated Protein Kinase 1; D048052:Mitogen-Activated Protein Kinase 3
G protein-coupled receptor; leukotriene B4 receptor 1; receptor for advanced glycation end products