68Ga-PSMA-HBED-CC PET imaging in breast carcinoma patients.
BACKGROUND
To report on imaging findings using68Ga-PSMA-HBED-CC PET in a series of 19 breast carcinoma patients.


METHODS
68Ga-PSMA-HBED-CC PET imaging results obtained were compared to routinely performed staging examinations and analyzed as to lesion location and progesterone receptor status.


RESULTS
Out of 81 tumor lesions identified, 84% were identified on68Ga-PSMA-HBED-CC PET.68Ga-PSMA-HBED-CC SUVmean values of distant metastases proved significantly higher (mean, 6.86, SD, 5.68) when compared to those of primary or local recurrences (mean, 2.45, SD, 2.55, p = 0.04) or involved lymph nodes (mean, 3.18, SD, 1.79, p = 0.011). SUVmean values of progesterone receptor-positive lesions proved not significantly different from progesterone receptor-negative lesions. SUV values derived from FDG PET/CT, available in seven patients, and68Ga-PSMA-HBED-CC PET/CT imaging proved weakly correlated (r = 0.407, p = 0.015).


CONCLUSIONS
68Ga-PSMA-HBED-CC PET/CT imaging in breast carcinoma confirms the reported considerable variation of PSMA expression on human solid tumors using immunohistochemistry.
Department of Nuclear Medicine, University of Pretoria and Steve Biko Academic Hospital, Private Bag X169, Pretoria, 0001, South Africa. mike.sathekge@up.ac.za.
Mike
M
Sathekge
Department of Nuclear Medicine, University of Pretoria and Steve Biko Academic Hospital, Private Bag X169, Pretoria, 0001, South Africa.
Thabo
T
Lengana
Department of Nuclear Medicine, University of Pretoria and Steve Biko Academic Hospital, Private Bag X169, Pretoria, 0001, South Africa.
Moshe
M
Modiselle
Department of Nuclear Medicine, University of Pretoria and Steve Biko Academic Hospital, Private Bag X169, Pretoria, 0001, South Africa.
Mariza
M
Vorster
Department of Nuclear Medicine, University of Pretoria and Steve Biko Academic Hospital, Private Bag X169, Pretoria, 0001, South Africa.
JanRijn
J
Zeevaart
Department of Nuclear Medicine, University of Pretoria and Steve Biko Academic Hospital, Private Bag X169, Pretoria, 0001, South Africa.|Department of Nuclear Medicine, AZ Groeninge, Kortrijk, Belgium.
Alex
A
Maes
Department of Nuclear Medicine, University of Pretoria and Steve Biko Academic Hospital, Private Bag X169, Pretoria, 0001, South Africa.
Thomas
T
Ebenhan
Department of Nuclear Medicine, University of Pretoria and Steve Biko Academic Hospital, Private Bag X169, Pretoria, 0001, South Africa.|Department of Radiology and Nuclear Medicine, University Ghent, Ghent, Belgium.
Christophe
C
Van de Wiele
D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000000981:diagnostic imaging*; D002277:Carcinoma / Q000000981:diagnostic imaging*; D004492:Edetic Acid / Q000031:analogs & derivatives; D005260:Female; D019788:Fluorodeoxyglucose F18; D005709:Gallium Isotopes; D005710:Gallium Radioisotopes; D006801:Humans; D008875:Middle Aged; D009842:Oligopeptides; D009942:Organometallic Compounds; D000072078:Positron Emission Tomography Computed Tomography; D019275:Radiopharmaceuticals
D005709:Gallium Isotopes; D005710:Gallium Radioisotopes; D009842:Oligopeptides; D009942:Organometallic Compounds; D019275:Radiopharmaceuticals; C000718244:gallium 68 PSMA-11; D019788:Fluorodeoxyglucose F18; D004492:Edetic Acid
68Ga-PSMA; Breast cancer; PET/CT