Porosity of temporary denture soft liners containing antifungal agents.
To evaluate the porosity of a tissue conditioner (Softone) and a temporary resilient liner (Trusoft) modified by minimum inhibitory concentrations (MICs) of antifungal agents for Candida albicans biofilm.
The porosity was measured by water absorption, based on exclusion of the plasticizer effect. Initially, it was determined by sorption isotherms that the adequate storage solution for specimens (65×10×3.3 mm) of both materials was 50% anhydrous calcium chloride (S50). Then, the porosity factor (PF) was calculated for the study groups (n=10) formed by specimens without (control) or with drug incorporation at MICs (nystatin: Ny-0.032 g, chlorhexidine diacetate: Chx-0.064 g, or ketoconazole: Ke-0.128 g each per gram of soft liner powder) after storage in distilled water or S50 for 24 h, seven and 14 d. Data were statistically analyzed by 4-way repeated measures ANOVA and Tukey's test (α=.05).
Ke resulted in no significant changes in PF for both liners in water over 14 days (p>0.05). Compared with the controls, Softone and Trusoft PFs were increased at 14-day water immersion only after addition of Ny and Chx, and Chx, respectively (p<0.05). Both materials showed no significant changes in PF in up to 14 days of S50 immersion, compared with the controls (p>0.05). In all experimental conditions, Softone and Trusoft PFs were significantly lower when immersed in S50 compared with distilled water (p<0.05).
The addition of antifungals at MICs resulted in no harmful effects for the porosity of both temporary soft liners in different periods of water immersion, except for Chx and Ny in Softone and Chx in Trusoft at 14 days. No deleterious effect was observed for the porosity of both soft liners modified by the drugs at MICs over 14 days of S50 immersion.
Universidade de São Paulo, Faculdade de Odontologia de Bauru, Departamento de Prótese, Bauru, SP, Brasil.
Jozely Francisca Mello
JF
Lima
Universidade de São Paulo, Faculdade de Odontologia de Bauru, Departamento de Prótese, Bauru, SP, Brasil.
Janaína Gomes
JG
Maciel
Universidade de São Paulo, Faculdade de Odontologia de Bauru, Departamento de Prótese, Bauru, SP, Brasil.
Juliana
J
Hotta
Universidade Estadual Paulista, Faculdade de Odontologia de Araraquara, Departamento de Materiais Odontológicos e Prótese, Araraquara, SP, Brasil.
Ana Carolina Pero
AC
Vizoto
Universidade de São Paulo, Faculdade de Odontologia de Bauru, Departamento de Odontopediatria, Ortodontia e Saúde Coletiva, Bauru, SP, Brasil.
Heitor Marques
HM
Honório
Universidade Estadual de Ponta Grossa, Departamento de Odontologia, Ponta Grossa, PR, Brasil.
Vanessa Migliorini
VM
Urban
Universidade de São Paulo, Faculdade de Odontologia de Bauru, Departamento de Prótese, Bauru, SP, Brasil.
Karin Hermana
KH
Neppelenbroek
D000180:Acrylic Resins / Q000737:chemistry*; D000704:Analysis of Variance; D000935:Antifungal Agents / Q000737:chemistry*; D018441:Biofilms / Q000187:drug effects; D002122:Calcium Chloride / Q000737:chemistry; D002710:Chlorhexidine / Q000737:chemistry; D003822:Denture Liners; D003833:Denture, Partial, Temporary; D007101:Immersion; D007654:Ketoconazole / Q000737:chemistry; D008422:Materials Testing; D008826:Microbial Sensitivity Tests; D009761:Nystatin / Q000737:chemistry; D011109:Polymethacrylic Acids / Q000737:chemistry*; D016062:Porosity; D015203:Reproducibility of Results; D013499:Surface Properties; D013997:Time Factors; D014867:Water / Q000737:chemistry
D000180:Acrylic Resins; D000935:Antifungal Agents; D011109:Polymethacrylic Acids; C540406:softone; D014867:Water; D009761:Nystatin; D002122:Calcium Chloride; D002710:Chlorhexidine; D007654:Ketoconazole