Are Cystic Fibrosis Aspergillus fumigatus Isolates Different? Intermicrobial Interactions with Pseudomonas.
Pseudomonas aeruginosa and Aspergillus fumigatus are the leading bacterial and fungal pathogens in cystic fibrosis (CF). We have shown that Af biofilms are susceptible to Pseudomonas, particularly CF phenotypes. Those studies were performed with a reference virulent non-CF Aspergillus. Pseudomonas resident in CF airways undergo profound genetic and phenotypic adaptations to the abnormal environment. Studies have also indicated Aspergillus from CF patients have unexpected profiles of antifungal susceptibility. This would suggest that Aspergillus isolates from CF patients may be different or altered from other clinical isolates. It is important to know whether Aspergillus may also be altered, as a result of that CF environment, in susceptibility to Pseudomonas. CF Aspergillus proved not different in that susceptibility.
California Institute for Medical Research, 2260 Clove Dr., San Jose, CA, 95128, USA.|Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.|Department of Microbiology, Istanbul University, Istanbul, Turkey.
Hasan
H
Nazik
Division of Pulmonology, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.
Richard B
RB
Moss
California Institute for Medical Research, 2260 Clove Dr., San Jose, CA, 95128, USA.
Vyshnavi
V
Karna
California Institute for Medical Research, 2260 Clove Dr., San Jose, CA, 95128, USA.|Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Karl V
KV
Clemons
Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.|Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Niaz
N
Banaei
California Institute for Medical Research, 2260 Clove Dr., San Jose, CA, 95128, USA.
Kevin
K
Cohen
California Institute for Medical Research, 2260 Clove Dr., San Jose, CA, 95128, USA.
Varun
V
Choudhary
California Institute for Medical Research, 2260 Clove Dr., San Jose, CA, 95128, USA. stevens@stanford.edu.|Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA. stevens@stanford.edu.
David A
http://orcid.org/0000-0002-5861-5716
DA
Stevens
D000935:Antifungal Agents / Q000494:pharmacology; D001228:Aspergillosis / Q000382:microbiology*; D001232:Aspergillus fumigatus / Q000187:drug effects / Q000302:isolation & purification* / Q000502:physiology*; D018441:Biofilms / Q000254:growth & development*; D003550:Cystic Fibrosis / Q000150:complications*; D006801:Humans; D056265:Microbial Interactions; D050296:Microbial Viability; D011550:Pseudomonas aeruginosa / Q000302:isolation & purification / Q000502:physiology*
D000935:Antifungal Agents
Aspergillus; Biofilm; Cystic fibrosis; Intermicrobial interaction; Pseudomonas