A novel metronidazole fluorescent nanosensor based on graphene quantum dots embedded silica molecularly imprinted polymer.
A novel optical nanosensor for detection of Metronidazole in biological samples was reported. Graphene quantum dots embedded silica molecular imprinted polymer (GQDs-embedded SMIP) was synthesized and used as a selective fluorescent probe for Metronidazole detection. The new synthesized GQDs-embedded SMIP showed strong fluorescent emission at 450nm excited at 365nm which quenched in presence of Metronidazole as a template molecule.. The quenching was proportional to the concentration of Metronidazole in a linear range of at least 0.2μM to 15μM. The limit of detection for metronidazole determination was obtained 0.15μM. The nanosensor successfully worked in plasma matrixes.
Center of Excellence in Electrochemistry, School of Chemistry, College of Science, University of Tehran, Tehran, Iran.
Mina
M
Mehrzad-Samarin
Center of Excellence in Electrochemistry, School of Chemistry, College of Science, University of Tehran, Tehran, Iran. Electronic address: faridbodf@khayam.ut.ac.ir.
Farnoush
F
Faridbod
Center of Excellence in Electrochemistry, School of Chemistry, College of Science, University of Tehran, Tehran, Iran.
Amin Shiralizadeh
AS
Dezfuli
Center of Excellence in Electrochemistry, School of Chemistry, College of Science, University of Tehran, Tehran, Iran.
Mohammad Reza
MR
Ganjali
D000890:Anti-Infective Agents / Q000097:blood*; D015374:Biosensing Techniques / Q000379:methods; D005456:Fluorescent Dyes / Q000737:chemistry*; D006108:Graphite / Q000737:chemistry*; D006801:Humans; D057230:Limit of Detection; D008795:Metronidazole / Q000097:blood*; D054802:Molecular Imprinting; D011108:Polymers / Q000737:chemistry; D045663:Quantum Dots / Q000737:chemistry* / Q000648:ultrastructure; D012822:Silicon Dioxide / Q000737:chemistry*; D013050:Spectrometry, Fluorescence / Q000379:methods
D000890:Anti-Infective Agents; D005456:Fluorescent Dyes; D011108:Polymers; D008795:Metronidazole; D012822:Silicon Dioxide; D006108:Graphite
Fluorescence detection; Graphene quantum dots; Inorganic silica polymer; Metronidazole; Molecularly imprinted polymer; Nanosensor