Exercise-induced modulation of histone H4 acetylation status and cytokines levels in patients with schizophrenia.
The present study aimed to investigate the short and long-term effects of a concurrent exercise protocol on global histone H4 acetylation levels and inflammatory markers (interleukin-4 (IL-4), interleukin-6 (IL-6), interferon gamma (IFN-γ) and cortisol) in phytohemagglutinin-stimulated peripheral blood mononuclear cells (PBMC) and in peripheral blood of patients with schizophrenia (SZ), as well the intervention impact on anthropometric characteristics. Seventeen individuals were submitted to the intervention three times a week and blood samples were collected pre, 30, 60 and 90days after the intervention started. A remarkable reduction on body mass index and body mass were observed following intervention. The protocol also induced a histone H4 hypoacetylation status in PBMC all times evaluated when compared to the pre intervention period. Although the IL-4 and cortisol levels were not altered in response to the intervention, a reduction in IL-6 production during the 60 and 90days compared to the pre intervention period was observed. Finally, diminished IFN-γ production was found in the 90days period compared to the pre intervention and 30days after periods. In addition, systemic IL-6 levels were lower at 60 and 90days compared to the pre intervention. The concurrent exercise protocol was able to improve anthropometric characteristics in patients with SZ, engaging the modulation of cytokine and histone H4 acetylation levels.
Programa de Pós Graduação em Biociências e Reabilitação do Centro Universitário Metodista-IPA, Porto Alegre, RS, Brazil.
Caroline
C
Lavratti
Cellular and Molecular Immunology Lab., Department of Health Basic Sciences, Federal University of Health Sciences of Porto Alegre, Porto Alegre, Brazil.
Gilson
G
Dorneles
Programa de Pós Graduação em Biociências e Reabilitação do Centro Universitário Metodista-IPA, Porto Alegre, RS, Brazil.
Daniela
D
Pochmann
Programa de Pós Graduação em Biociências e Reabilitação do Centro Universitário Metodista-IPA, Porto Alegre, RS, Brazil; Cellular and Molecular Immunology Lab., Department of Health Basic Sciences, Federal University of Health Sciences of Porto Alegre, Porto Alegre, Brazil.
Alessandra
A
Peres
Curso de Fisioterapia do Centro Universitário Metodista-IPA, Porto Alegre, RS, Brazil.
Andréia
A
Bard
Curso de Fisioterapia do Centro Universitário Metodista-IPA, Porto Alegre, RS, Brazil.
Lucas
L
de Lima Schipper
Programa de Pós Graduação em Ciências da Reabilitação, Universidade Federal de Ciências da Saúde de Porto Alegre, RS, Brazil.
Pedro
P
Dal Lago
Programa de Pós Graduação em Biociências e Reabilitação do Centro Universitário Metodista-IPA, Porto Alegre, RS, Brazil.
Luciane Carniel
LC
Wagner
Programa de Pós Graduação em Biociências e Reabilitação do Centro Universitário Metodista-IPA, Porto Alegre, RS, Brazil. Electronic address: vivielsner.fisiologia@gmail.com.
Viviane Rostirola
VR
Elsner
D000107:Acetylation; D000328:Adult; D016207:Cytokines / Q000097:blood* / Q000378:metabolism; D015444:Exercise; D005260:Female; D006657:Histones / Q000378:metabolism*; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D055070:Resistance Training / Q000379:methods*; D012559:Schizophrenia / Q000097:blood* / Q000534:rehabilitation*; D018709:Statistics, Nonparametric; D013997:Time Factors
D016207:Cytokines; D006657:Histones; D006854:Hydrocortisone
Body mass; Body mass index; Exercise; Global histone H4 acetylation levels; Inflammatory response; Schizophrenia