SalaciaExtract Improves Postprandial Glucose and Insulin Response: A Randomized Double-Blind, Placebo Controlled, Crossover Study in Healthy Volunteers.
Thirty-five healthy subjects were randomly assigned to different doses ofSalacia chinensisextract (200 mg, 300 mg, and 500 mg SCE) capsules and compared with placebo. It is a placebo controlled randomized crossover design study. Subjects were given oral sucrose solution along with capsules and plasma glucose and insulin responses were analyzed. Blood samples were collected at 0, 30, 60, 90, 120, and 180 minutes after administration. AUC insulin significantly lowered after ingestion of SCE. No significant adverse events were observed. Reducing glucose and insulin is very important in reducing postprandial hyperglycemia.
Research and Development, OmniActive Health Technologies Ltd., Mumbai, India.
Shankaranarayanan
S
Jeykodi
Research and Development, OmniActive Health Technologies Inc., Prince Edward Island, Canada.
Jayant
J
Deshpande
Scientific and Clinical Affairs, OmniActive Health Technologies Inc., Morristown, NJ, USA.
Vijaya
0000-0002-7397-715X
V
Juturu
D000328:Adult; D001786:Blood Glucose / Q000187:drug effects* / Q000378:metabolism; D018592:Cross-Over Studies; D004311:Double-Blind Method; D064368:Healthy Volunteers; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D019518:Postprandial Period / Q000187:drug effects; D049918:Salacia; D055815:Young Adult
D001786:Blood Glucose; D007328:Insulin; D010936:Plant Extracts