Association of serum 25-hydroxyvitamin D status with bone mineral density in 0-7 year old children.
OBJECTIVE
To describe the status of serum 25-hydoxyvitamin D [25(OH)D] concentrations and identify the relationship between 25(OH)D and bone mineral density (BMD). In an effort to explore the appropriate definition of vitamin D (VD) deficiency in 0-7 year old children.


RESULTS
The median serum 25(OH)D concentrations was 62.9 nmol/L and 28.9% of the children had a low 25(OH)D (< 50 nmol/L). And a linear relation between 25(OH)D concentrations and BMD was surveyed (r = 0.144 , P < 0.001). After adjusting for the confounders, serum 25(OH)D was positively associated with BMD (β = 172.0, 95%CI = 142.8-201.2, P < 0.001), and low 25(OH)D (< 75 nmol/L) had a high stake for low BMD (OR = 1.424, 95%CI = 1.145-1.769, P = 0.001). Additionally, there was a nonlinear relation between 25(OH)D and low BMD, and a critical value for 25(OH)D of 75 nmol/L appeared for low BMD. The prevalence of low BMD was 14.1% in children with 25(OH)D ≥ 75 nmol/L, much lower than that of the concentrations between 50-75 nmol/L and < 50 nmol/L.


METHODS
A total of 4,846 children 0-7 years old were recruited in Jiangsu Province, China. BMD and serum 25(OH)D concentrations were determined by quantitative ultrasound and enzyme-linked immunosorbent assay, respectively. Linear regression and logistic regression analyses were used to assess the association of 25(OH)D concentrations with BMD.


CONCLUSIONS
Serum 25(OH)D concentrations was related with BMD and 25(OH)D concentrations < 75 nmol/L might be a more appropriate definition of VD deficiency in 0-7 year old children.
Department of Child Health Care, the Second Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, 210011, China.|Department of Child Health Care, Jiangsu Women and Children Health Hospital, Women and Child Branch Hospital of Jiangsu Province Hospital, the First Affiliated Hospital with Nanjing Medical University, Nanjing, 210036, China.|Nanjing Maternity and Child Health Care Institute, Nanjing Maternity and Child Health Care Hospital, Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University, Nanjing, 210029, China.
Yanrong
Y
Fu
Department of Child Health Care, Jiangsu Women and Children Health Hospital, Women and Child Branch Hospital of Jiangsu Province Hospital, the First Affiliated Hospital with Nanjing Medical University, Nanjing, 210036, China.
Youfang
Y
Hu
Department of Child Health Care, Jiangsu Women and Children Health Hospital, Women and Child Branch Hospital of Jiangsu Province Hospital, the First Affiliated Hospital with Nanjing Medical University, Nanjing, 210036, China.
Zhenying
Z
Qin
Department of Child Health Care, Jiangsu Women and Children Health Hospital, Women and Child Branch Hospital of Jiangsu Province Hospital, the First Affiliated Hospital with Nanjing Medical University, Nanjing, 210036, China.
Yan
Y
Zhao
Department of Child Health Care, Jiangsu Women and Children Health Hospital, Women and Child Branch Hospital of Jiangsu Province Hospital, the First Affiliated Hospital with Nanjing Medical University, Nanjing, 210036, China.
Zi
Z
Yang
Department of Pediatrics, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, China.
Yinfang
Y
Li
Department of Child Health Care, Jiangsu Women and Children Health Hospital, Women and Child Branch Hospital of Jiangsu Province Hospital, the First Affiliated Hospital with Nanjing Medical University, Nanjing, 210036, China.
Guanyu
G
Liang
Department of Child Health Care, Jiangning Maternity and Child Health Care Institute, Nanjing, 211100, China.
Heyun
H
Lv
Department of Child Health Care, Drum Tower Maternity and Child Health Care Institute, Nanjing, 210009, China.
Hong
H
Hong
Department of Child Health Care, Suzhou Municipal Hospital, Suzhou, 215000, China.
Yuan
Y
Song
Department of Child Health Care, Wuxi Maternity and Child Health Care Hospital, Wuxi, 214000, China.
Yarong
Y
Wei
Department of Child Health Care, Huai'an Maternity and Child Health Care Hospital, Huai'an, 223001, China.
Hongni
H
Yue
Department of Child Health Care, Yancheng Maternity and Child Health Care Institute, Yancheng, 224000, China.
Wen
W
Zheng
Department of Child Health Care, Dafeng Maternity and Child Health Care Hospital, Dafeng, 224100, China.
Guoqin
G
Liu
Department of Child Health Care, Nantong Maternity and Child Health Care Hospital, Nantong, 226000, China.
Yufei
Y
Ni
Department of Child Health Care, Xuzhou Children's Hospital, Xuzhou, 221000, China.
Mei
M
Zhu
Department of Child Health Care, Xinghua Maternity and Child Health Care Hospital, Xinghua, 225700, China.
Aiping
A
Wu
Department of Child Health Care, Kunshan Maternity and Child Health Care Institute, Kunshan, 215300, China.
Juhua
J
Yan
Nanjing Maternity and Child Health Care Institute, Nanjing Maternity and Child Health Care Hospital, Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University, Nanjing, 210029, China.
Chenbo
C
Ji
Nanjing Maternity and Child Health Care Institute, Nanjing Maternity and Child Health Care Hospital, Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University, Nanjing, 210029, China.
Xirong
X
Guo
Nanjing Maternity and Child Health Care Institute, Nanjing Maternity and Child Health Care Hospital, Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University, Nanjing, 210029, China.
Juan
J
Wen
Department of Child Health Care, Jiangsu Women and Children Health Hospital, Women and Child Branch Hospital of Jiangsu Province Hospital, the First Affiliated Hospital with Nanjing Medical University, Nanjing, 210036, China.
Rui
R
Qin
D000367:Age Factors; D015415:Biomarkers / Q000097:blood; D015519:Bone Density; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006304:Health Status; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D016014:Linear Models; D016015:Logistic Models; D008297:Male; D017711:Nonlinear Dynamics; D015995:Prevalence; D014463:Ultrasonography; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology / Q000503:physiopathology
D015415:Biomarkers; D014807:Vitamin D; C104450:25-hydroxyvitamin D
0-7 year old children; bone mineral density; serum 25-hydoxyvitamin D