Reproductive and Developmental Toxicity Screening Test of Ethyl Hydrogen Adipate in Rats.
This study aimed to evaluate the potential toxicity and safety of ethyl hydrogen adipate (EHA) by determining its effect on the reproductive function and development of Sprague-Dawley (SD) rats at dose levels of 0 (control), 200, 400, and 800 mg/kg/day. One male and five females of the 800 mg/kg/day died. Body weight loss was observed in the males of the 800 mg/kg/day and in females of the 400 and 800 mg/kg/day. In addition, mating indices decreased and pre-implantation loss rates increased in parental animals of the 400 and 800 mg/kg/day. The gestation index decreased in the male and female rats of the 800 mg/kg/day. Moreover, the body weight of the pups from the 800 mg/kg/day group decreased on post-parturition day 4. These results indicated that the no-observed-adverse-effect level of EHA for parental males and females was 400 mg/kg/day and 200 mg/kg/day, respectively, and that for pups was 400 mg/kg/day.
Biotoxtech Co., Ltd., Cheongju, Korea.
Chunja
C
Nam
Biotoxtech Co., Ltd., Cheongju, Korea.
Jae-Sik
JS
Hwang
Biotoxtech Co., Ltd., Cheongju, Korea.
Kyoung-Goo
KG
Han
Environmental Health Research Department, National Institute of Environmental Research, Incheon, Korea.
Eunhye
E
Jo
Environmental Health Research Department, National Institute of Environmental Research, Incheon, Korea.
Sun-Kyoung
SK
Yoo
Environmental Health Research Department, National Institute of Environmental Research, Incheon, Korea.
Ig-Chun
IC
Eom
Department of Laboratory Animal Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju, Korea.
Jong-Koo
JK
Kang
Ethyl hydrogen adipate; Rat; Reproductive and development toxicity; Screening test