Prodrug approach: An overview of recent cases.
In this review we highlight the most modern trends in the prodrug strategy. In drug research and development, the prodrug concept has found a number of useful applications. Selected examples of this approach are provided in this paper and they are classified according to the aim of their design.
Departamento de Química Orgánica, Universidad de Alcalá, 28871 Alcalá de Henares, Madrid, Spain.
Valentina
V
Abet
Departamento de Química Orgánica, Universidad de Alcalá, 28871 Alcalá de Henares, Madrid, Spain.
Fabiana
F
Filace
Departamento de Química Orgánica, Universidad de Alcalá, 28871 Alcalá de Henares, Madrid, Spain.
Javier
J
Recio
Departamento de Química Orgánica, Universidad de Alcalá, 28871 Alcalá de Henares, Madrid, Spain. Electronic address: julio.alvarez@uah.es.
Julio
J
Alvarez-Builla
Departamento de Química Orgánica, Universidad de Alcalá, 28871 Alcalá de Henares, Madrid, Spain. Electronic address: carolina.burgos@uah.es.
Carolina
C
Burgos
D065966:Absorption, Physicochemical; D000818:Animals; D002463:Cell Membrane Permeability; D055808:Drug Discovery / Q000379:methods*; D006801:Humans; D011355:Prodrugs / Q000009:adverse effects / Q000737:chemistry / Q000378:metabolism; D012995:Solubility; D014867:Water / Q000737:chemistry
D011355:Prodrugs; D014867:Water
Bioprecursors; Carrier-linked prodrug; Prodrug