Dampening Positive Affect and Neural Reward Responding in Healthy Children: Implications for Affective Inflexibility.
Blunted reward processing is evident in and may contribute to the onset of major depressive disorder. However, it is unclear what mechanisms contribute to the development of blunted reward-response prior to depression onset. The current study examined how individual differences in the tendency to dampen positive affect, an affect regulation strategy that decreases positive affect, are associated with reward responding and related brain activation in 39 healthy children (ages 7-10; 51% female; 79% White). To do this, we examined neural responses to winning a reward (candy) within the context of a previous loss, win, or neutral outcome. Whole-brain regression analyses revealed that self-reported tendencies to engage in dampening were associated with blunted striatum and thalamic activation during a winning outcome when following a previous loss outcome, as compared to when following a neutral outcome. This finding was above and beyond the influence of current depressive symptoms. However, tendencies to dampen positive affect were not associated with neural activity during the second of 2 consecutive win outcomes, and thus did not support the notion that dampening is associated with an inability to maintain reward responding. In youth, tendencies to dampen positive affect may be associated with less ability to flexibly upregulate neural reward responding following a loss, possibly leading to the development of affective inflexibility and increased vulnerability to depression. Dampening positive affect may be one mechanism that contributes to aberrant neural reward responding via affective inflexibility and may be a target for prevention in youth.
a Department of Psychiatry , Washington University in St. Louis School of Medicine.
Kirsten Elizabeth
0000-0001-9367-6621
KE
Gilbert
b Department of Psychology , Stony Brook University.
Katherine Rose
KR
Luking
c Section on Development & Affective Neuroscience , National Institute of Mental Health.
David
D
Pagliaccio
a Department of Psychiatry , Washington University in St. Louis School of Medicine.
Joan
J
L Luby
d Department of Psychology , Washington University in St. Louis.|e Department of Psychiatry , Washington University in St. Louis.|f Department of Radiology , Washington University in St. Louis.
Deanna M
DM
Barch
D000339:Affect / Q000502:physiology*; D001921:Brain / Q000000981:diagnostic imaging* / Q000502:physiology*; D002648:Child; D003865:Major Depressive Disorder / Q000000981:diagnostic imaging / Q000523:psychology; D005149:Facial Expression; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D011597:Psychomotor Performance / Q000502:physiology; D012201:Reward