Opinion of the Scientific Committee on Consumer Safety (SCCS) - Final version of the opinion on Phenoxyethanol in cosmetic products.
The SCCS considers 2-phenoxyethanol safe for use as a preservative with a maximum concentration of 1.0%, taking into account the information provided. The toxicokinetics default factor of 4.0 can be reduced to 1.0 yielding a minimum Margin of Safety (MoS) of 25 instead of 100 for the safety assessment of 2-phenoxyethanol. Therefore, the MoS of about 50 for children also covers this specific age group who might be higher exposed to 2-phenoxyethanol than adults. This Opinion does not take into account exposure from sources other than cosmetics.
SCCS Secretariat at the European Commission, Directorate General for Health and Food Safety, 11, rue E. Ruppert, L-2920, Luxembourg.
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D000367:Age Factors; D000818:Animals; D002675:Child, Preschool; D003257:Consumer Product Safety; D003358:Cosmetics / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D005026:Ethylene Glycols / Q000009:adverse effects*; D006801:Humans; D011310:Preservatives, Pharmaceutical / Q000009:adverse effects*; D018570:Risk Assessment; D012307:Risk Factors; D018675:Toxicity Tests / Q000379:methods*; D066007:Toxicokinetics
D003358:Cosmetics; D005026:Ethylene Glycols; D011310:Preservatives, Pharmaceutical; C005398:phenoxyethanol
CAS no. 122-99-6; EC no. 204-589-7; Phenoxyethanol; Regulation 1223/2009; SCCS; Scientific opinion