An Observational Longitudinal Study Investigating the Effectiveness of 75 mg Pregabalin Post-Hemodialysis among Uremic Pruritus Patients.
A prospective, observational, longitudinal study was conducted to assess the effectiveness of 75 mg pregabalin (PG) post-hemodialysis (pHD) for treatment-resistant uremic pruritus (UP). A total of forty-five patients completed the entire six week follow-up. At the baseline assessment, the majority of the patients were distressed by the UP frequency and intensity. Sleep (mean = 3.30 ± 1.1), leisure/social activities (mean = 2.90 ± 0.80) and distribution (mean = 2.92 ± 0.34) were the three domains that were primarily effected by the UP. Overall, further reduction in the 5D-itching scale (IS) was noted at day 42, which confirmed a sustained (B = -12.729, CI -13.257 to -12.201, p < 0.001) relief of pruritus severity among patients with treatment-resistant pruritus. Patients with a higher serum calcium level had a score difference of +1 from the other patients (B = 1.010, p = 0.061). There was a reduction of 12 points compared to the baseline 5D-IS for each patient on day 42 after using pregabalin 75 mg PD pHD for 42 days, which represented major relief. Among the demographic factors, only gender was significantly associated with the 5D-IS score.
School of Pharmacy, Monash University, Bandar Sunway, Jalan Lagoon Selatan, 46700 Selangor, Malaysia.|College of Clinical Pharmacy, King Faisal University, Alahsa, Saudi Arabia.
Tahir Mehmood
TM
Khan
School of Pharmacy, Monash University, Bandar Sunway, Jalan Lagoon Selatan, 46700 Selangor, Malaysia.
David Bin-Chia
DB
Wu
School of Pharmacy, Monash University, Bandar Sunway, Jalan Lagoon Selatan, 46700 Selangor, Malaysia.
Bey-Hing
BH
Goh
School of Pharmacy, Monash University, Bandar Sunway, Jalan Lagoon Selatan, 46700 Selangor, Malaysia.
Learn-Han
LH
Lee
Director and Senior consultant, Aljaber Kidney and Dialysis Center, Alahsa, Eastern Province, Saudi Arabia.
Abdul Aziz
AA
Alhafez
School of Pharmaceutical Science, University Sains Malaysia Pulau Pinang, Malaysia.
Syed Azhar
SA
Syed Sulaiman
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D005500:Follow-Up Studies; D008137:Longitudinal Studies; D010865:Pilot Projects; D000069583:Pregabalin / Q000008:administration & dosage; D011446:Prospective Studies; D011537:Pruritus / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D006435:Renal Dialysis; D014511:Uremia / Q000473:pathology / Q000503:physiopathology / Q000628:therapy
D000069583:Pregabalin