Pre-mRNA mis-splicing of sarcomeric genes in heart failure.
Pre-mRNA splicing is an important biological process that allows production of multiple proteins from a single gene in the genome, and mainly contributes to protein diversity in eukaryotic organisms. Alternative splicing is commonly governed by RNA binding proteins to meet the ever-changing demands of the cell. However, the mis-splicing may lead to human diseases. In the heart of human, mis-regulation of alternative splicing has been associated with heart failure. In this short review, we focus on alternative splicing of sarcomeric genes and review mis-splicing related heart failure with relatively well studied Sarcomeric genes and splicing mechanisms with identified regulatory factors. The perspective of alternative splicing based therapeutic strategies in heart failure has also been discussed.
Animal Science, College of Agriculture and Natural Resources, University of Wyoming, Laramie, WY 82071, USA.
Chaoqun
C
Zhu
Animal Science, College of Agriculture and Natural Resources, University of Wyoming, Laramie, WY 82071, USA; College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100, China.
Zhilong
Z
Chen
Animal Science, College of Agriculture and Natural Resources, University of Wyoming, Laramie, WY 82071, USA.
Wei
W
Guo
D017398:Alternative Splicing; D000818:Animals; D006333:Heart Failure / Q000235:genetics / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D006801:Humans; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D012322:RNA Precursors / Q000235:genetics / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D012518:Sarcomeres / Q000235:genetics / Q000378:metabolism* / Q000473:pathology
D012322:RNA Precursors; D016601:RNA-Binding Proteins
Alternative splicing; Heart failure; Sarcomeric genes; Splicing factor