Oxygenation dynamics of sepsis patients undergoing far-infrared intervention based on near-infrared spectroscopy.
Near-infrared spectroscopy (NIRS; continuous wave type) is a noninvasive tool for detecting the relative change of oxyhemoglobin and deoxyhemoglobin. To make this change, intervention methods must be applied. This study determined the hemodynamics of 44 healthy participants and 35 patients with sepsis during exposure to FIR as a novel physical intervention approach. Local microcirculation of their brachioradialis was monitored during exposure and recovery through NIRS. The variations in blood flow and microvascular reaction were determined by conducting paired and unpaired t tests. The oxyhemoglobin levels of the healthy participants increased continuously, even during recovery. In contrast to expextations, the oxyhemoglobin levels of the patients plateaued after only 5 min of FIR illumination. The proposed method has potential applications for ensuring efficient treatment and facilitating doctors in diagnosing the functions of vessels in intensive care units. Mapping diagrams of HbO2in healthy males and males with sepsis illustrated unique scenarios during the process.
Department of Photonics, National Chiao Tung University, Hsinchu, Taiwan.
Kuei-Hung
KH
Chuang
Division of Pulmonary Medicine, Department of Internal Medicine and Department of Critical Care Medicine, Chung Shan Medical University Hospital, Taiwan.|School of Medicine, Chung Shan Medical University Hospital, Taiwan.
Ming-Lung
ML
Chuang
Division of Pulmonary Medicine, Department of Internal Medicine and Department of Critical Care Medicine, Chung Shan Medical University Hospital, Taiwan.
Sung-Kien
SK
Sia
Department of Photonics, National Chiao Tung University, Hsinchu, Taiwan.
Chia-Wei
CW
Sun
D000368:Aged; D005260:Female; D006439:Hemodynamics; D006801:Humans; D007259:Infrared Rays; D008297:Male; D008833:Microcirculation; D008875:Middle Aged; D008991:Monitoring, Physiologic / Q000295:instrumentation / Q000379:methods; D010101:Oxygen Consumption; D010108:Oxyhemoglobins / Q000378:metabolism; D010775:Photic Stimulation; D012039:Regional Blood Flow; D018805:Sepsis / Q000378:metabolism*; D019265:Spectroscopy, Near-Infrared / Q000295:instrumentation / Q000379:methods
D010108:Oxyhemoglobins
far-infrared intervention; intensive care medicine; near-infrared spectroscopy; oxygenation dynamics; sepsis