Dysregulated corticostriatal activity in open-field behavior and the head-twitch response induced by the hallucinogen 2,5-dimethoxy-4-iodoamphetamine.
The substituted amphetamine, 2,5-dimethoxy-4-iodoamphetamine (DOI), is a hallucinogen that has been used to model a variety of psychiatric conditions. Here, we studied the effect of DOI on neural activity recorded simultaneously in the primary motor cortex (M1) and dorsal striatum of freely behaving FvB/N mice. DOI significantly decreased the firing rate of individually isolated neurons in M1 and dorsal striatum relative to pre-drug baseline. It also induced a bursting pattern of activity by increasing both the number of spikes within a burst and burst duration. In addition, DOI increased coincident firing between simultaneously recorded neuron pairs within the striatum and between M1 and dorsal striatum. Local field potential (LFP) activity also increased in coherence between M1 and dorsal striatum after DOI in the low frequency gamma band (30-50 Hz), while corticostriatal coherence in delta, theta, alpha, and beta activity decreased. We also assessed corticostriatal LFP activity in relation to the DOI-induced head-twitch response (HTR), a readily identifiable behavior used to assess potential treatments for the conditions it models. The HTR was associated with increased delta and decreased theta power in both M1 and dorsal striatum. Together, our results suggest that DOI dysregulates corticostriatal communication and that the HTR is associated with this dysregulation.
Indiana University Bloomington, Department of Psychological and Brain Sciences, Program in Neuroscience, 1101 E. 10th St., Bloomington, IN 47405, USA.
Claudia
C
Rangel-Barajas
Indiana University Bloomington, Department of Psychological and Brain Sciences, Program in Neuroscience, 1101 E. 10th St., Bloomington, IN 47405, USA; Intellectual and Developmental Disabilities Research Center, Semel Institute, Department of Psychiatry & Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, USA.
Ana María
AM
Estrada-Sánchez
Indiana University Bloomington, Department of Psychological and Brain Sciences, Program in Neuroscience, 1101 E. 10th St., Bloomington, IN 47405, USA.
Scott J
SJ
Barton
University of North Texas Health Science Center, The Department of Pharmacology and Neuroscience, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA.
Robert R
RR
Luedtke
Indiana University Bloomington, Department of Psychological and Brain Sciences, Program in Neuroscience, 1101 E. 10th St., Bloomington, IN 47405, USA. Electronic address: rebec@indiana.edu.
George V
GV
Rebec
D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D000662:Amphetamines / Q000633:toxicity*; D000818:Animals; D058256:Brain Waves / Q000187:drug effects / Q000502:physiology; D005106:Exploratory Behavior / Q000187:drug effects / Q000502:physiology*; D006213:Hallucinogens / Q000633:toxicity*; D019416:Head Movements / Q000187:drug effects / Q000502:physiology*; D008297:Male; D051379:Mice; D009044:Motor Cortex / Q000187:drug effects / Q000502:physiology*; D017072:Neostriatum / Q000187:drug effects / Q000502:physiology*
D000662:Amphetamines; D006213:Hallucinogens; C015952:4-iodo-2,5-dimethoxyphenylisopropylamine
5-HT(2A) serotonin receptor; DOI; Head-twitch response; In vivo electrophysiology