Mismatch-repair-deficient metastatic pancreatic ductal adenocarcinoma with a germline PALB2 mutation: unusual genetics, unusual clinical course.
Department of Internal Medicine III and Comprehensive Cancer Center, Klinikum Grosshadern, Ludwig-Maximilians-University of Munich, Munich, Germany.
S
S
Boeck
Institute of Pathology, Ludwig-Maximilians-University of Munich, Munich, Germany
Y
Y
Mehraein
DKTK, German Cancer Consortium, German Cancer Research Center,Heidelberg, Germany.
S
S
Ormanns
Department of Internal Medicine III and Comprehensive Cancer Center, Klinikum Grosshadern, Ludwig-Maximilians-University of Munich, Munich, Germany.
S
S
Kruger
Department of Internal Medicine III and Comprehensive Cancer Center, Klinikum Grosshadern, Ludwig-Maximilians-University of Munich, Munich, Germany.
C Benedikt
CB
Westphalen
Department of Internal Medicine III and Comprehensive Cancer Center, Klinikum Grosshadern, Ludwig-Maximilians-University of Munich, Munich, Germany.
M
M
Haas
DKTK, German Cancer Consortium, German Cancer Research Center,Heidelberg, Germany.
A
A
Jung
Institute of Pathology, Ludwig-Maximilians-University of Munich, Munich, Germany|DKTK, German Cancer Consortium, German Cancer Research Center,Heidelberg, Germany.
T
T
Kirchner
Department of Internal Medicine III and Comprehensive Cancer Center, Klinikum Grosshadern, Ludwig-Maximilians-University of Munich, Munich, Germany.|Institute of Pathology, Ludwig-Maximilians-University of Munich, Munich, Germany
V
V
Heinemann
D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D021441:Carcinoma, Pancreatic Ductal / Q000188:drug therapy / Q000235:genetics*; D053843:DNA Mismatch Repair / Q000235:genetics*; D000076164:Fanconi Anemia Complementation Group N Protein / Q000235:genetics*; D018095:Germ-Line Mutation; D006801:Humans; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000188:drug therapy / Q000235:genetics*
D061067:Antibodies, Monoclonal, Humanized; D000076164:Fanconi Anemia Complementation Group N Protein; C512790:PALB2 protein, human; C582435:pembrolizumab