Preparation of Reductant-Responsive N-Maleoyl-Functional Chitosan/Poly(vinyl alcohol) Nanofibers for Drug Delivery.
Chitosan/poly(vinyl alcohol) (CS/PVA) hybrid nanofibers via electrospinning have been extensively used as wound dressing materials. However, there are still several drawbacks associated with their processing procedures and material properties, including the necessity of using acid solutions as spinning solvents, the need of employing highly toxic cross-linkers, and the lack of stimuli-responsive functions. In this context, water-soluble N-maleoyl functional chitosan (MCS) was successfully synthesized and well characterized. Using neutral deionized water as a spinning solvent, MCS/PVA nanofibers were prepared via electrospinning under the optimal operating conditions. Instead of using conventional cross-linking methodologies, the MCS/PVA nanofibers were further cross-linked by UV-irradiation with allyl disulfide as a cross-linker. The resulting disulfide cross-linked MCS/PVA (ss-MCS/PVA) nanofibers have demonstrated great water stability, high water regain ability, insignificant cytotoxicity, and reductant-responsive functions. With a successful loading of an antibiotic tetracycline hydrochloride (TCH) and those favorable material features, ss-MCS/PVA nanofibers are capable of being exploited as a potential wound dressing to promote the healing of various types of wounds.
Polymeric Biomaterials Laboratory, Department of Fiber and Composite Materials, Feng Chia University , Taichung 40724, Taiwan, R.O.C.
Chih-Kuang
CK
Chen
Polymeric Biomaterials Laboratory, Department of Fiber and Composite Materials, Feng Chia University , Taichung 40724, Taiwan, R.O.C.
Szu-Chieh
SC
Huang
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D001458:Bandages; D001672:Biocompatible Materials; D002448:Cell Adhesion / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D048271:Chitosan / Q000737:chemistry*; D016503:Drug Delivery Systems; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects; D051379:Mice; D057139:Nanofibers / Q000737:chemistry*; D011108:Polymers / Q000008:administration & dosage* / Q000737:chemistry; D011142:Polyvinyl Alcohol / Q000737:chemistry*; D019163:Reducing Agents / Q000737:chemistry*; D012867:Skin / Q000166:cytology / Q000187:drug effects; D014945:Wound Healing
D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D011108:Polymers; D019163:Reducing Agents; D011142:Polyvinyl Alcohol; D048271:Chitosan
MCS/PVA nanofibers; N-maleoyl-functional chitosan; UV-irradiated cross-linking; drug delivery; reductant−responsive nanofibers