A Dual Base Flipping Mechanism for Archaeal Mismatch Repair.
In this issue of Structure, Nakae et al. (2016) report the structure of the archaeal EndoMS endonuclease, which cleaves DNA containing mismatched base pairs. Their data demonstrate a unique dual base flipping mechanism, providing intriguing insights into the molecular evolution of protein machineries involved in DNA mismatch repair.
Graduate School of Engineering, Kyoto University, Kyoto daigaku-katsura, Nishikyo-ku, Kyoto 615-8530, Japan. Electronic address: ariyoshi.mariko.2x@kyoto-u.ac.jp.
Mariko
M
Ariyoshi
Graduate School of Biostudies, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan.
Kosuke
K
Morikawa
D001105:Archaea; D020137:Base Pair Mismatch; D020029:Base Pairing; D001483:Base Sequence; D004247:DNA / Q000737:chemistry; D053843:DNA Mismatch Repair; D004260:DNA Repair
D004247:DNA