Role of tripeptidyl peptidase II in MHC class I antigen presentation: Biological characteristics, cellular crosstalk and signaling.
Tripeptidyl peptidase II (TPPII) is a multifunctional cytoplasmic serine protease. The main function of TPPII is to cleave proteasome-generated peptides into tripeptides, which can then be further degraded into free amino acids. Recent evidence suggests that TPPII plays an important role in epitope generation, but the mechanisms of TPPII in MHC class I antigen presentation remain unclear. Recent research has shed new light on the mechanisms and functions of TPPII in MHC class I antigen presentation. We therefore provide an updated review of the biological characteristics of TPPII and explore its role in MHC class I antigen presentation.
Department of Infectious Disease, Shanghai Jiao Tong University, Affiliated Sixth People's Hospital, Shanghai 200233, China.
Quanhui
Q
Tan
Department of Infectious Disease, Shanghai Jiao Tong University, Affiliated Sixth People's Hospital, Shanghai 200233, China.
Siyuan
S
Ma
Department of Infectious Disease, Shanghai Jiao Tong University, Affiliated Sixth People's Hospital, Shanghai 200233, China.
Jianjun
J
Hu
Department of Infectious Disease, Shanghai Jiao Tong University, Affiliated Sixth People's Hospital, Shanghai 200233, China.
Xiaohua
X
Chen
Department of Infectious Disease, Shanghai Jiao Tong University, Affiliated Sixth People's Hospital, Shanghai 200233, China.
Yongsheng
Y
Yu
Department of Infectious Disease, Shanghai Jiao Tong University, Affiliated Sixth People's Hospital, Shanghai 200233, China.
Guoqing
G
Zang
Department of Infectious Disease, Shanghai Jiao Tong University, Affiliated Sixth People's Hospital, Shanghai 200233, China. Electronic address: tzhhao@163.com.
Zhenghao
Z
Tang
D000626:Aminopeptidases / Q000502:physiology*; D000818:Animals; D003593:Cytoplasm / Q000378:metabolism*; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases / Q000502:physiology*; D015395:Histocompatibility Antigens Class I / Q000378:metabolism*; D006801:Humans; D020239:Receptor Cross-Talk / Q000502:physiology*; D012697:Serine Endopeptidases / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
D015395:Histocompatibility Antigens Class I; D000626:Aminopeptidases; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; C048001:tripeptidyl-peptidase 2; D012697:Serine Endopeptidases
Antigen presentation; MHC class I; TPPII