A Review of the Course and Treatment of Non-Infectious Uveitis during Pregnancy.
Inflammatory conditions such as autoimmune uveitis often occur in women of childbearing age. During pregnancy, women may experience exacerbations of their disease in the first trimester. In the later stages of pregnancy, however, the uveitis tends to remain less active. The management of uveitis during pregnancy is a challenging task, forcing the physician to re-evaluate the patient's current therapy and offer alternative options that pose the least risk to the patient and fetus. This article will review treatments widely used for uveitis, including corticosteroid therapy, anti-metabolites, calcineurin inhibitors, and biologic therapy. It will evaluate the use of these medications in pregnancy and the postpartum state.
a Uveitis and Immunology Service , Massachusetts Eye and Ear Infirmary , Boston , MA , USA.
Lindsay A
LA
Grotting
a Uveitis and Immunology Service , Massachusetts Eye and Ear Infirmary , Boston , MA , USA.
George N
GN
Papaliodis
D000328:Adult; D000963:Antimetabolites / Q000627:therapeutic use; D001327:Autoimmune Diseases / Q000188:drug therapy / Q000503:physiopathology; D001691:Biological Therapy; D065095:Calcineurin Inhibitors / Q000627:therapeutic use; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D049590:Postpartum Period; D011247:Pregnancy; D011248:Pregnancy Complications; D014605:Uveitis / Q000188:drug therapy* / Q000503:physiopathology*
D000963:Antimetabolites; D065095:Calcineurin Inhibitors; D005938:Glucocorticoids
Autoimmune disease; biologics; lactation; ocular inflammatory disease