A Novel Insulin/Glucose Model after a Mixed-Meal Test in Patients with Type 1 Diabetes on Insulin Pump Therapy.
Current closed-loop insulin delivery methods stem from sophisticated models of the glucose-insulin (G/I) system, mostly based on complex studies employing glucose tracer technology. We tested the performance of a new minimal model (GLUKINSLOOP 2.0) of the G/I system to characterize the glucose and insulin dynamics during multiple mixed meal tests (MMT) of different sizes in patients with type 1 diabetes (T1D) on insulin pump therapy (continuous subcutaneous insulin infusion, CSII). The GLUKINSLOOP 2.0 identified the G/I system, provided a close fit of the G/I time-courses and showed acceptable reproducibility of the G/I system parameters in repeated studies of identical and double-sized MMTs. This model can provide a fairly good and reproducible description of the G/I system in T1D patients on CSII, and it may be applied to create a bank of "virtual" patients. Our results might be relevant at improving the architecture of upcoming closed-loop CSII systems.
The Microsoft Research - University of Trento Centre for Computational and Systems Biology (COSBI), Rovereto (TN), Italy.
Luca
L
Marchetti
The Microsoft Research - University of Trento Centre for Computational and Systems Biology (COSBI), Rovereto (TN), Italy.|Department of Mathematics, University of Trento, Trento, Italy.
Federico
F
Reali
Department of Medicine, Section of Endocrinology, University of Verona School of Medicine, Verona, Italy.
Marco
M
Dauriz
Department of Medicine, Section of Endocrinology, University of Verona School of Medicine, Verona, Italy.
Corinna
C
Brangani
Department of Medicine, Section of Endocrinology, University of Verona School of Medicine, Verona, Italy.
Linda
L
Boselli
Department of Medicine, Section of Endocrinology, University of Verona School of Medicine, Verona, Italy.
Giulia
G
Ceradini
Department of Medicine, Section of Endocrinology, University of Verona School of Medicine, Verona, Italy.|Division of Endocrinology and Metabolic Diseases, Azienda Ospedaliera Universitaria Integrata, Verona, Italy.
Enzo
E
Bonora
Department of Clinical and Experimental Medicine, University of Parma, Parma, Italy.|Division of Endocrinology, Azienda Ospedaliera Universitaria of Parma, Italy.
Riccardo C
RC
Bonadonna
The Microsoft Research - University of Trento Centre for Computational and Systems Biology (COSBI), Rovereto (TN), Italy.|Department of Mathematics, University of Trento, Trento, Italy.
Corrado
C
Priami
D000293:Adolescent; D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000032:analysis*; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy*; D005247:Feeding Behavior; D005260:Female; D006801:Humans; D007328:Insulin / Q000008:administration & dosage* / Q000097:blood*; D007332:Insulin Infusion Systems; D008297:Male; D062407:Meals; D008875:Middle Aged; D015233:Models, Statistical; D055815:Young Adult
D001786:Blood Glucose; D007328:Insulin