Therapeutic Potential of Stem Cells Strategy for Cardiovascular Diseases.
Despite development of medicine, cardiovascular diseases (CVDs) are still the leading cause of mortality and morbidity worldwide. Over the past 10 years, various stem cells have been utilized in therapeutic strategies for the treatment of CVDs. CVDs are characterized by a broad range of pathological reactions including inflammation, necrosis, hyperplasia, and hypertrophy. However, the causes of CVDs are still unclear. While there is a limit to the currently available target-dependent treatments, the therapeutic potential of stem cells is very attractive for the treatment of CVDs because of their paracrine effects, anti-inflammatory activity, and immunomodulatory capacity. Various studies have recently reported increased therapeutic potential of transplantation of microRNA- (miRNA-) overexpressing stem cells or small-molecule-treated cells. In addition to treatment with drugs or overexpressed miRNA in stem cells, stem cell-derived extracellular vesicles also have therapeutic potential because they can deliver the stem cell-specific RNA and protein into the host cell, thereby improving cell viability. Here, we reported the state of stem cell-based therapy for the treatment of CVDs and the potential for cell-free based therapy.
Department of Integrated Omics for Biomedical Sciences, Graduate School, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-759, Republic of Korea.
Chang Youn
CY
Lee
Department of Biology Education, College of Education, Pusan National University, Busan 609-735, Republic of Korea.
Ran
0000-0001-5048-5235
R
Kim
Institute for Bio-Medical Convergence, Catholic Kwandong University International St. Mary's Hospital, Incheon 404-834, Republic of Korea.
Onju
0000-0003-3910-7211
O
Ham
Department of Biology Education, College of Education, Pusan National University, Busan 609-735, Republic of Korea.
Jihyun
J
Lee
Department of Biology Education, College of Education, Pusan National University, Busan 609-735, Republic of Korea.
Pilseog
0000-0003-4653-5230
P
Kim
Department of Biology Education, College of Education, Pusan National University, Busan 609-735, Republic of Korea.
Seokyeon
0000-0002-5460-1747
S
Lee
Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.
Sekyung
S
Oh
Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA.
Hojin
H
Lee
Department of Molecular Physiology, College of Pharmacy, Kyungpook National University, Daegu 702-701, Republic of Korea.
Minyoung
M
Lee
Department of Life Systems, Sookmyung Women's University, 52 Hyochangwon-gil, Yongsan-gu, Seoul 140-742, Republic of Korea.
Jongmin
J
Kim
Department of Biology Education, College of Education, Pusan National University, Busan 609-735, Republic of Korea.
Woochul
0000-0001-7367-2586
W
Chang