Disease implication of hyper-Hippo signalling.
The Hippo signalling pathway regulates cellular proliferation, apoptosis and differentiation, thus exerting profound effects on cellular homeostasis. Inhibition of Hippo signalling has been frequently implicated in human cancers, indicating a well-known tumour suppressor function of the Hippo pathway. However, it is less certain whether and how hyperactivation of the Hippo pathway affects biological outcome in living cells. This review describes current knowledge of the regulatory mechanisms of the Hippo pathway, mainly focusing on hyperactivation of the Hippo signalling nexus. The disease implications of hyperactivated Hippo signalling have also been discussed, including arrhythmogenic cardiomyopathy, Sveinsson's chorioretinal atrophy, Alzheimer's disease, amyotrophic lateral sclerosis and diabetes. By highlighting the significance of disease-relevant Hippo signalling activation, this review can offer exciting prospects to address the onset and potential reversal of Hippo-related disorders.
Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, NY 10065, USA lawang@mail.ndmctsgh.edu.tw.
Shu-Ping
SP
Wang
Graduate Institute of Life Sciences, National Defense Medical Center, 161, Sec. 6, Minquan E. Rd., Neihu Dist, Taipei City 114, Taiwan.
Lan-Hsin
0000-0002-5586-3466
LH
Wang
D000544:Alzheimer Disease / Q000378:metabolism; D000690:Amyotrophic Lateral Sclerosis / Q000378:metabolism; D000818:Animals; D017209:Apoptosis; D001145:Arrhythmias, Cardiac / Q000378:metabolism; D002454:Cell Differentiation; D049109:Cell Proliferation; D003317:Corneal Dystrophies, Hereditary / Q000378:metabolism; D003920:Diabetes Mellitus / Q000378:metabolism; D005786:Gene Expression Regulation; D000090683:Hippo Signaling Pathway; D006706:Homeostasis; D006801:Humans; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D012162:Retinal Degeneration / Q000378:metabolism; D015398:Signal Transduction; D015854:Up-Regulation
D017346:Protein Serine-Threonine Kinases
Alzheimer's disease; Hippo pathway; Sveinsson's chorioretinal atrophy; amyotrophic lateral sclerosis; arrhythmogenic cardiomyopathy; diabetes