Late-Onset Pulmonary Fistula after Resection of Pulmonary Metastasis from Colorectal Cancer Following Perioperative Chemotherapy with Bevacizumab.
Chemotherapy with bevacizumab followed by surgery is now a viable treatment option for pulmonary metastasis from colorectal cancer (CRC). We herein report two cases of late-onset pulmonary fistula after resection of pulmonary metastasis from CRC following perioperative chemotherapy with bevacizumab. One patient suffered from a late-onset pulmonary fistula that occurred 3 months after pulmonary resection, which was treated with chest drainage and pleurodesis. The other patient suffered from a pulmonary fistula after three cycles of chemotherapy with bevacizumab after pulmonary resection, and underwent surgery to treat the fistula.
Department of General Thoracic Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
Ryu
R
Kanzaki
Department of General Thoracic Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
Yasushi
Y
Shintani
Division of Thoracic Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Masayoshi
M
Inoue
Department of General Thoracic Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
Tomohiro
T
Kawamura
Department of General Thoracic Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
Soichiro
S
Funaki
Department of General Thoracic Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
Masato
M
Minami
Department of General Thoracic Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
Meinoshin
M
Okumura
D000328:Adult; D000368:Aged; D000074322:Antineoplastic Agents, Immunological / Q000008:administration & dosage / Q000009:adverse effects*; D000068258:Bevacizumab / Q000008:administration & dosage / Q000009:adverse effects*; D017024:Chemotherapy, Adjuvant; D015179:Colorectal Neoplasms / Q000473:pathology*; D004322:Drainage / Q000379:methods; D005260:Female; D006801:Humans; D008171:Lung Diseases / Q000000981:diagnostic imaging / Q000209:etiology* / Q000628:therapy; D008175:Lung Neoplasms / Q000556:secondary* / Q000628:therapy*; D008297:Male; D059146:Metastasectomy / Q000009:adverse effects* / Q000379:methods; D020360:Neoadjuvant Therapy / Q000009:adverse effects*; D018700:Pleurodesis; D011013:Pneumonectomy / Q000009:adverse effects*; D016156:Respiratory Tract Fistula / Q000000981:diagnostic imaging / Q000209:etiology* / Q000628:therapy; D012307:Risk Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
D000074322:Antineoplastic Agents, Immunological; D000068258:Bevacizumab
bevacizumab; colorectal cancer; pulmonary fistula; pulmonary metastasectomy