Increased level of Hsp90-beta in bronchoalveolar lavage fluid correlates with lymphatic invasion and advanced stage of lung cancer patients.
BACKGROUND
The purpose of this work is to explore the correlation between Hsp90-beta level in broncheoalveolar lavage fluid (BALF) and lung cancer.


METHODS
Hsp90-beta level was measured by immunohistochemistry and enzyme-linked immunosorbent assay. Sensitivity and specificity of Hsp90-beta were calculated by receiver operator characteristic curve.


RESULTS
BALF in patients with lung cancer showed a higher expression of Hsp90-beta than those with benign lung disease (P<0.05). Elevated Hsp90-beta was closely related to lymphatic invasion and advanced stage of patients with lung cancer (P<0.05). The sensitivity of BALF Hsp90-beta for discerning lung cancer from patients with benign disease was 82.56% and specificity was 97.56%.


CONCLUSIONS
Increased BALF Hsp90-beta correlates with lymphatic invasion and advanced stage of patients with lung cancer, suggesting it could be a diagnostic indicator for patients with lung cancer.
Department of Respiratory Medicine, First Affiliated Hospital, Xi'an Medical University Xi'an, China.
Biaoxue
B
Rong
Department of Respiratory Medicine, Gansu Provincial Hospital Lanzhou, China.
Xiguang
X
Cai
Department of Respiratory Medicine, Gansu Provincial Hospital Lanzhou, China.
Hua
H
Liu
Department of Respiratory Medicine, Affiliated Hospital of Jining Medical University Jining, China.
Tian
T
Fu
Department of Statistics and Epidemiology, Medical College, Lanzhou University Lanzhou, China.
Wenlong
W
Gao
Department of Cancer Care, Lanzhou University Second Hospital Lanzhou, China.
Chongchong
C
Zhao
Department of Respiratory Medicine, Xi'an North Hospital Xian, China.
Yurong
Y
Lin
BALF; Hsp90-beta diagnosis; Lung cancer; bronchoalveolar lavage fluid