High-sensitivity C-reactive protein in stroke patients - The importance in consideration of influence of multiple factors in the predictability for disease severity and death.
High sensitivity C-reactive protein (hsCRP) has been evaluated as a biomarker in stroke and relevant pathological diseases. While its predictive values in several pathological phenotypes have been confirmed, controversy exists among different studies. This review summarizes reports of the predictive values of hsCRP for the diagnosis, etiology, prognosis and mortality of stroke diseases. The current literature suggests that CRP expression is influenced by multiple factors, such as polymorphisms, the genomic backgrounds and gender. However, few reported studies analyzed data based on all these multiple factors. Future studies should focus on comprehensive analysis based on multiple factors.
Center of Integrative Research, The First Hospital of Qiqihar City, Qiqihar, Heilongjiang 161005, PR China; Department of Orthopedic Surgery and BME-Campbell Clinic, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Hong
H
Yu
Department of Orthopedic Surgery and BME-Campbell Clinic, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Yue
Y
Huang
Center of Integrative Research, The First Hospital of Qiqihar City, Qiqihar, Heilongjiang 161005, PR China.
XinYu
X
Chen
Center of Integrative Research, The First Hospital of Qiqihar City, Qiqihar, Heilongjiang 161005, PR China.
WenBao
W
Nie
Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, PR China.
YongJun
Y
Wang
Department of Orthopedic Surgery and BME-Campbell Clinic, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Yan
Y
Jiao
Department of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Guy L
GL
Reed
Department of Orthopedic Surgery and BME-Campbell Clinic, University of Tennessee Health Science Center, Memphis, TN 38163, USA. Electronic address: wgu@uthsc.edu.
Weikuan
W
Gu
Center of Integrative Research, The First Hospital of Qiqihar City, Qiqihar, Heilongjiang 161005, PR China. Electronic address: qsdyyych@163.com.
Hong
H
Chen
D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D011110:Polymorphism, Genetic; D020521:Stroke / Q000097:blood* / Q000453:epidemiology / Q000473:pathology
D015415:Biomarkers; D002097:C-Reactive Protein
Atherosclerosis; High sensitivity C-reactive protein (hsCRP); Ischemic; Polymorphism; Predictability; Stroke