SPArking Interest in the Long Noncoding RNA World: A New Class of 5' SnoRNA-Stabilized LncRNA that Influences Alternative Splicing.
Delving deeply into the locus deleted in Prader-Willi syndrome, in this issue of Molecular Cell, Wu et al. (2016) identify SPA RNAs, a new class of 5' snoRNA-capped lncRNAs that sequester RNA binding proteins and influence alternative splicing.
School of Anatomy, Physiology, and Human Biology, University of Western Australia, Crawley 6009, Australia; Harry Perkins Institute of Medical Research, Centre for Medical Research, University of Western Australia, Crawley 6009, Australia. Electronic address: ruohan.li@perkins.uwa.edu.au.
Ruohan
R
Li
School of Anatomy, Physiology, and Human Biology, University of Western Australia, Crawley 6009, Australia; Harry Perkins Institute of Medical Research, Centre for Medical Research, University of Western Australia, Crawley 6009, Australia. Electronic address: archa.fox@uwa.edu.au.
Archa H
AH
Fox
D017398:Alternative Splicing; D001483:Base Sequence; D002884:Chromosomes, Human, Pair 15; D005095:Exoribonucleases / Q000235:genetics / Q000378:metabolism; D056426:Genetic Loci; D018392:Genomic Imprinting; D000066449:Human Embryonic Stem Cells / Q000378:metabolism / Q000473:pathology; D006801:Humans; D011218:Prader-Willi Syndrome / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D011485:Protein Binding; D012319:RNA Polymerase II / Q000235:genetics / Q000378:metabolism; D062085:RNA, Long Noncoding / Q000235:genetics* / Q000378:metabolism; D020537:RNA, Small Nucleolar / Q000235:genetics* / Q000378:metabolism; D016601:RNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D017384:Sequence Deletion; D014158:Transcription, Genetic
D062085:RNA, Long Noncoding; D020537:RNA, Small Nucleolar; D016601:RNA-Binding Proteins; D012319:RNA Polymerase II; D005095:Exoribonucleases; C120903:XRN2 protein, human