Diffusion-mediated129Xe gas depolarization in magnetic field gradients during continuous-flow optical pumping.
The production of large volumes of highly polarized noble gases like helium and xenon is vital to applications of magnetic resonance imaging and spectroscopy with hyperpolarized (HP) gas in humans. In the past ten years,129Xe has become the gas of choice due to its lower cost, higher availability, relatively high tissue solubility, and wide range of chemical shift values. Though near unity levels of xenon polarization have been achieved in-cell using stopped-flow Spin Exchange Optical Pumping (SEOP), these levels are currently unmatched by continuous-flow SEOP methods. Among the various mechanisms that cause xenon relaxation, such as persistent and transient xenon dimers, wall collisions, and interactions with oxygen, relaxation due to diffusion in magnetic field gradients, caused by rapidly changing magnetic field strength and direction, is often ignored. However, during continuous-flow SEOP production, magnetic field gradients may not have a negligible contribution, especially considering that this methodology requires the combined use of magnets with very different characteristics (low field for spin exchange optical pumping and high field for the reduction of xenon depolarization in the solid state during the freeze out phase) that, when placed together, inevitably create magnetic field gradients along the gas-flow-path. Here, a combination of finite element analysis and Monte Carlo simulations is used to determine the effect of such magnetic field gradients on xenon gas polarization with applications to a specific, continuous-flow hyperpolarization system.
Department of Physics and Astronomy, University of North Carolina at Chapel Hill, USA; Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, USA.
Alex
A
Burant
Department of Physics and Astronomy, University of North Carolina at Chapel Hill, USA; Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, USA. Electronic address: rtbranca@unc.edu.
Rosa Tamara
RT
Branca
D060526:Magnetic Fields; D008279:Magnetic Resonance Imaging; D014979:Xenon Isotopes
D014979:Xenon Isotopes; C000614971:Xenon-129
Continuous-flow; Gas-phase relaxation; Hyperpolarized (129)Xe; Longitudinal relaxation; Magnetic field gradients; Magnetic resonance imaging