Management of breast cancer brain metastases: A practical review.
Brain metastases are a common, and frequently challenging, clinical problem in the contemporary management of metastatic breast cancer. While the management of extracranial metastatic breast cancer is now strongly defined by tumour phenotype, this approach is not so well defined for brain metastases. We review available evidence regarding management of brain metastases, including the limited breast-cancer-specific data. A framework for management according to breast cancer phenotype is proposed.
Division of Radiation Oncology and Cancer Imaging, Peter MacCallum Cancer Centre, East Melbourne, VIC, Australia. Electronic address: claire.phillips@petermac.org.
Claire
C
Phillips
Royal Brisbane and Women's Hospital, University of Queensland, Brisbane, Queensland, Australia.
Rosalind
R
Jeffree
NHMRC Clinical Trials Centre, University of Sydney, NSW, Australia.
Mustafa
M
Khasraw
D001932:Brain Neoplasms / Q000556:secondary*; D001943:Breast Neoplasms / Q000473:pathology*; D019468:Disease Management; D005260:Female; D006801:Humans
Brain metastases; Breast cancer; Radiotherapy; Targeted therapy