[Local fixation of antibiotics by fibrin spray : In bone defects with soft tissue involvement].
In acute and chronic bone infections with concomitant soft tissue involvement the current gold standard is radical surgical debridement including explantation of the infected prosthetic devices. This is followed by initiation of systemic antibiotic therapy appropriate for the antibiogram. Several revision operations are often necessary to achieve complete healing. Additional treatment with local antibiotics or antibiotic-containing substances is routinely used in bone surgery. Apart from the typical procedures with commercially available products, we have conducted a study with 21 patients by application of local antibiotic treatment in combination with the fibrin glue spray technique and evaluated the results. Out of nine wounds of the lower extremities with bone involvement, total healing could be achieved in eight cases. We were also successful in two out of three very complex pelvic wounds; however, as expected the implant infections were complicated. Out of the seven desolate cases we were only able to achieve complete long-term healing in two cases. In the meantime we routinely use the described method in such special disastrous infection situations; however, this is carried out only in combination with established surgical procedures in sepsis surgery and anti-infection management.
Klinik für Unfall-, Hand- und Wiederherstellungschirurgie, Klinikum der Goethe-Universität Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Deutschland. maren.janko@kgu.de.
Maren
M
Janko
Klinik für Unfall-, Hand- und Wiederherstellungschirurgie, Klinikum der Goethe-Universität Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Deutschland.
Christoph
C
Nau
Klinik für Unfall-, Hand- und Wiederherstellungschirurgie, Klinikum der Goethe-Universität Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Deutschland.
Ingo
I
Marzi
Klinik für Unfall-, Hand- und Wiederherstellungschirurgie, Klinikum der Goethe-Universität Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Deutschland.
Johannes
J
Frank
D000287:Administration, Topical; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D002908:Chronic Disease; D003131:Combined Modality Therapy; D003646:Debridement; D005260:Female; D015718:Fibrin Tissue Adhesive / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009779:Occlusive Dressings; D010019:Osteomyelitis / Q000628:therapy*; D012086:Reoperation; D012189:Retrospective Studies; D018461:Soft Tissue Infections / Q000628:therapy*; D013530:Surgical Wound Infection / Q000628:therapy*; D055815:Young Adult
D000900:Anti-Bacterial Agents; D015718:Fibrin Tissue Adhesive
Antibiotics; Bone infection; Fibrin glue; Infections; Osteitis