Serum Lipoprotein (a) Levels in Black South African Type 2 Diabetes Mellitus Patients.
Lipoprotein (a) (Lp(a)) which is a low-density lipoprotein-like particle containing apo(a) is considered as an emergent cardiovascular risk factor. Type 2 diabetes mellitus (T2DM) is associated with a two- to threefold increase in the risk of cardiovascular disease (CVD). The aim of this study was to investigate the levels of Lp(a) in Black South African T2DM patients and its association with other metabolic factors. 67 T2DM patients and 48 healthy control participants were recruited for the cross-sectional study. The Lp(a) level was determined by ELISA and the result was analyzed using SPSS. The Lp(a) level in diabetics was found to be significantly increased (P= 0.001) when compared to the normal healthy group. In the diabetic group, the Lp(a) levels correlated significantly with the duration of diabetes (P= 0.008) and oxidized LDL (ox-LDL) levels (P= 0.03) and decreased total antioxidant capacity (P= 0.001). The third tertile of Lp(a) was significantly correlated with increased ox-LDL, C-reactive protein, and triglycerides and decreased total antioxidant capacity.
Division of Medical Biochemistry, Department of Human Biology, Faculty of Health Sciences, Walter Sisulu University, Mthatha Campus, Nelson Mandela Drive, Mthatha 5100, South Africa.
Jim
0000-0001-7404-4178
J
Joseph
Division of Medical Biochemistry, Department of Human Biology, Faculty of Health Sciences, Walter Sisulu University, Mthatha Campus, Nelson Mandela Drive, Mthatha 5100, South Africa.
Farzana
0000-0003-2647-8056
F
Ganjifrockwala
Division of Medical Biochemistry, Department of Human Biology, Faculty of Health Sciences, Walter Sisulu University, Mthatha Campus, Nelson Mandela Drive, Mthatha 5100, South Africa.
Grace
0000-0002-4662-720X
G
George
D000975:Antioxidants / Q000378:metabolism; D044383:Black People; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005260:Female; D006801:Humans; D017270:Lipoprotein(a) / Q000097:blood*; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D013019:South Africa; D014280:Triglycerides / Q000097:blood
D000975:Antioxidants; D017270:Lipoprotein(a); D008077:Lipoproteins, LDL; D014280:Triglycerides; C099252:oxidized low density lipoprotein; D002097:C-Reactive Protein