A microtubule dynamics reconstitutional convention.
In vitro reconstitution is the fundamental test for identification of the core components of a biological process. In this issue, Moriwaki and Goshima (2016. J. Cell Biol. https://doi.org/10.1083/jcb.201604118) reconstitute all phases of microtubule dynamics through the inclusion of five key regulators and demonstrate that Polo kinase activity shifts the system from an interphase mode into an enhanced mitotic mode.
Department of Biology, University of North Carolina, Chapel Hill, NC 27599 kslep@bio.unc.edu.
Kevin C
KC
Slep
D000818:Animals; D006801:Humans; D008869:Microtubule-Associated Proteins; D008870:Microtubules / Q000378:metabolism*; D008954:Models, Biological; D008941:Spindle Apparatus / Q000378:metabolism; D014404:Tubulin / Q000378:metabolism
D008869:Microtubule-Associated Proteins; D014404:Tubulin