[Diagnostics and treatment of cholangiocellular carcinoma].
Cholangiocellular carcinoma (CCA) is the second most frequent primary liver carcinoma and is an aggressive tumor, which is mostly diagnosed in advanced stages. The overall survival is poor. Histpathological analysis of tumor biopsies or cytological analysis of biliary brushings can be used to confirm the diagnosis. A differentiation is made between distal, perihilar and intrahepatic CCA. The anatomical position determines the diagnostic and therapeutic strategy. Before diagnostic or therapeutic measures are undertaken it is essential to resolve biliary obstruction via endoscopic stenting or percutaneous biliary drainage. Depending on the tumor stage curative treatment options comprise radical surgical resection with hepaticojejunostomy or in selected cases liver transplantation. For intrahepatic or distal CCA liver transplantation is not indicated. In the palliative setting systemic chemotherapy with gemcitabine and cisplatin leads to a significant improvement in survival time.
Medizinische Klinik I (Gastroenterologie, Hepatologie und Infektiologie), Medizinische Universitätsklinik, Eberhard Karls Universität Tübingen, Otfried-Müller-Str. 10, 72076, Tübingen, Deutschland. lars.zender@med.uni-tuebingen.de.
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Zender
Medizinische Klinik I (Gastroenterologie, Hepatologie und Infektiologie), Medizinische Universitätsklinik, Eberhard Karls Universität Tübingen, Otfried-Müller-Str. 10, 72076, Tübingen, Deutschland.
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Malek
D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001650:Bile Duct Neoplasms / Q000473:pathology* / Q000628:therapy*; D018281:Cholangiocarcinoma / Q000473:pathology* / Q000628:therapy*; D003131:Combined Modality Therapy / Q000379:methods; D004322:Drainage / Q000379:methods; D016145:Endoscopy, Digestive System / Q000379:methods*; D019317:Evidence-Based Medicine; D006498:Hepatectomy / Q000379:methods; D006801:Humans; D016031:Liver Transplantation / Q000379:methods; D016896:Treatment Outcome
D000970:Antineoplastic Agents
Biopsy, bile ducts; Cholestasis; Gemcitabine/cisplatin; Liver transplantation; Surgery, cholangiocellular carcinoma