Treatment dilemmas in Guillain-Barré syndrome.
Guillain-Barré syndrome (GBS) is an acute polyradiculoneuropathy with a highly variable clinical course and outcome. Intravenous immunoglobulin (IVIg) and plasma exchange are proven effective treatments, but the efficacy has been demonstrated mainly on motor improvement in adults with a typical and severe form of GBS. In clinical practice, treatment dilemmas may occur in patients with a relatively mild presentation, variant forms of GBS, or when the onset of weakness was more than 2 weeks ago. Other therapeutic dilemmas may arise in patients who do not improve or even progress after initial treatment. We provide an overview of the current literature about therapeutic options in these situations, and additionally give our personal view that may serve as a basis for therapeutic decision-making.
Department of Neurology, Erasmus MC, Rotterdam, The Netherlands.
Christine
C
Verboon
Department of Neurology, Erasmus MC, Rotterdam, The Netherlands.
Pieter A
PA
van Doorn
Department of Neurology, Erasmus MC, Rotterdam, The Netherlands.|Immunology, Erasmus MC, Rotterdam, The Netherlands.
Bart C
BC
Jacobs
D000328:Adult; D018450:Disease Progression; D020275:Guillain-Barre Syndrome / Q000628:therapy*; D006801:Humans; D007116:Immunization, Passive; D009460:Neurologic Examination; D010951:Plasma Exchange; D016896:Treatment Outcome
GUILLAIN-BARRE SYNDROME