Heat shock protein 9-mediated inflammation reaction in patients with chronic prostatitis with erectile dysfunction.
To investigate the role of heat shock protein (HSP)-9 on the inflammation reaction present in patients with chronic prostatitis with erectile dysfunction (ED).



A total of 160 participants in the study were assigned to one of four groups of the same size. Group A had patients with chronic prostatitis and ED. Group B had patients with simple chronic prostatitis. Group C had patients with ED. And group D had healthy volunteers. The serum levels of HSP-9, CRP, TNF-a, IL-6 and CD3 in each individual's serum were tested by ELISA. Additionally, the National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI) and the International Index of Erectile Function-5 (IIEF-5) scores were recorded for each case.



The serum levels of HSP-9, CRP, TNF-a, IL-6 and CD3 in the serum of groups A and B were distinctly higher than those of groups C and D (p<0.05). While comparisons between groups A and B, or between groups C and D yielded no significant differences. Nevertheless, the NIH-CPSI scores in the group A were significantly higher (mostly moderately severe) than in the group B (mild to moderate). Furthermore, the IIEF-5 scores in the group A were also significantly higher than those in the group C.



The serum levels of HSP-9, CRP, TNF-a, IL-6 and CD3 in the sera of patients with chronic prostatitis with ED were clearly increased, reflecting a high degree of inflammation which may be related to the clinical manifestations in patients with chronic prostatitis and ED.
Department of Urology, Qilu Hospital of Shandong University, Jinan City, Shandong Province, China. seapeak_zh@aliyun.com.
H-F
HF
Zhao
X
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Li
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XZ
Jiang
D000368:Aged; D016022:Case-Control Studies; D002908:Chronic Disease; D016207:Cytokines; D004797:Enzyme-Linked Immunosorbent Assay; D007172:Erectile Dysfunction / Q000150:complications*; D006360:Heat-Shock Proteins; D006801:Humans; D007249:Inflammation; D008297:Male; D008875:Middle Aged; D011472:Prostatitis / Q000150:complications*
D016207:Cytokines; D006360:Heat-Shock Proteins