Synthesis and Assessment of Antibacterial Activities of Ruthenium(III) Mixed Ligand Complexes Containing 1,10-Phenanthroline and Guanide.
In this work, two complexes of ruthenium(III) ([Ru(phen)2Cl2]Cl·2H2O and [Ru(phen)2(G)Cl]2Cl·H2O) were synthesized from 1,10-phenanthroline alone as well as from both 1,10-phenanthroline and guanide. The synthesis was checked using halide test, conductance measurement, and spectroscopic (ICP-OES, FTIR, and UV/Vis) analysis. Their in vitro antibacterial activities were also investigated on two Gram-positive (Staphylococcus aureus(S. aureus) and methicillin resistantStaphylococcus aureus(MRSA)) and two Gram-negative (Escherichia coli(E. coli) andKlebsiella pneumoniae(K. pneumoniae)) bacteria. These complexes showed wide-range better activities than the commercially available controls (Chloramphenicol and Ciprofloxacin) against even the most drug resistantK. pneumoniae. [Ru(phen)2(G)Cl]2Cl·H2O inhibitedS. aureus, MRSA,E. coli, andK. pneumoniaeby 17.5%, 27.4%, 16%, and 52%, respectively, better than Chloramphenicol. It also inhibited these pathogens by 5.9%, 5.1%, 2.3%, and 17.2%, respectively, better than Ciprofloxacin. Similarly, [Ru(Phen)2(Cl)2]Cl·2H2O inhibited these pathogens by 11%, 8.7%, 0.1%, and 31.2%, respectively, better than Chloramphenicol. Therefore, after in vivo cytotoxicity investigations, these compounds can be considered as potential antibiotic drugs.
Science College, Bahir Dar University, Bahir Dar, Ethiopia.
Atakilt
0000-0002-5496-664X
A
Abebe
Science College, Bahir Dar University, Bahir Dar, Ethiopia.
Tizazu
T
Hailemariam