Mechanisms of Bacterial Colonization of Implants and Host Response.
The review focuses on the current knowledge and the most pertinent hypotheses regarding the local host immune response as the key factor for the pathogenesis of implant-associated infections. Although bacterial biofilms have long been recognized as causative agents, the link between the infection and the devastating inflammatory response, particularly the localized tissue destruction and bone degradation is less well understood. Understanding these consequences of infection, however, is of utmost importance, because suppressing inflammation and preventing bone destruction could be a novel, alternative therapeutic option in cases when eradicating the infections fails.
Zentrum für Orthopädie und Unfallchirurgie, Klinikum Ingolstadt, Krumenauerstraße 25, 85049, Ingolstadt, Germany. christof.wagner@klinikum-ingolstadt.de.
Christof
C
Wagner
Institut für Immunologie der Universität Heidelberg, Im Neuenheimer Feld 305, 69120, Heidelberg, Germany.
G Maria
GM
Hänsch
D001424:Bacterial Infections / Q000382:microbiology*; D018441:Biofilms / Q000254:growth & development*; D006801:Humans; D007249:Inflammation / Q000382:microbiology; D019736:Prostheses and Implants / Q000382:microbiology*; D016459:Prosthesis-Related Infections / Q000382:microbiology*
Bacterial biofilm; Immune response; Implant infection; Neutrophils; Osteolysis