Drug release kinetics from a drug-eluting stent with asymmetrical coat.
The aim of this study was to investigate the drug release profiles of biodegradable polymer sirolimus- or paclitaxel-eluting stents with asymmetrical coating (BPSES-A or BPPES-A) bothin vitroandin vivo.In vitro, the drug release profile was characterized by measuring the drug concentration by HPLC over a time-course.In vivo, a porcine aorta stenting model was employed. The results showed that the drug release rates of BPSES-A and BPPES-A were slower, more stable and less burst releasing than those of conventionally coated stents (BPSES-C and BPPES-C respectively), bothin vitroandin vivo. Based on thein vivoresults, the sirolimus and paclitaxel content of the local coronary wall was maintained at a higher and more effective level with BPSES-A and BPPES-A than with BPSES-C and BPPES-C, respectively. The drug levels in peripheral tissue samples were below detection levels. These data demonstrated the effectiveness of both sirolimus and paclitaxel as stent coating agents, and revealed the favorable drug release kinetics and pharmacokinetics of asymmetrical coated stents compared with conventional coated stents.
Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Niels Jernes Vej 109220 Aalborgo, Denmark, and Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, 180 Fenglin Road, 200032 Shanghai, Ch.
Haijun
H
Zhang
Shengjing Hospital of China Medical University, 36 Sanhao Street, Heping District, 110004 Shenyang, China.
Xiaodong
X
Li
Key Laboratory of Public Health Safety, Ministry of Education, School of Public Health,Fudan University, No.130, Dongan Road, 200032 Shanghai, China.
Wei
W
Deng
Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, 180 Fenglin Road, 200032 Shanghai, China.
Xiangfei
X
Wang
Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Niels Jernes Vej 109220 Aalborgo, Denmark,and Institute of Chemistry, Chinese Academy of Sciences, Zhongguancun North First Street 2, 100190 Beijing, China.
Shenguo
S
Wang
Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, 180 Fenglin Road, 200032 Shanghai, China.
Junbo
J
Ge
Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Niels Jernes Vej 109220 Aalborgo, Denmark,, egon.toft@qu.edu.qa.
Egon
E
Toft
D000818:Animals; D020099:Coated Materials, Biocompatible; D003331:Coronary Vessels / Q000378:metabolism / Q000601:surgery; D016503:Drug Delivery Systems; D065546:Drug Liberation; D054855:Drug-Eluting Stents; D066298:In Vitro Techniques; D007700:Kinetics; D008297:Male; D008422:Materials Testing; D017239:Paclitaxel / Q000097:blood / Q000493:pharmacokinetics; D020123:Sirolimus / Q000097:blood / Q000493:pharmacokinetics; D013552:Swine; D013556:Swine, Miniature
D020099:Coated Materials, Biocompatible; D017239:Paclitaxel; D020123:Sirolimus