In-vivo retinal imaging with off-axis full-field time-domain optical coherence tomography.
With a simple setup, mainly composed of a low coherence light source and a camera, full-field optical coherence tomography (FF-OCT) allows volumetric tissue imaging. However, fringe washout constrains its use in retinal imaging. Here, we present a novel motion-insensitive approach to FF-OCT, which introduces path-length differences between the reference and the sample light in neighboring pixels using an off-axis reference beam. The temporal carrier frequency in scanned time-domain OCT is replaced by a spatial carrier frequency. Volumetric in-vivo FF-OCT measurements of the human retina were acquired in only 1.3 s, comparable to the acquisition times of current clinically used OCT devices.
Helge
H
Sudkamp
Peter
P
Koch
Hendrik
H
Spahr
Dierck
D
Hillmann
Gesa
G
Franke
Michael
M
Münst
Fred
F
Reinholz
Reginald
R
Birngruber
Gereon
G
Hüttmann
D006801:Humans; D012160:Retina / Q000000981:diagnostic imaging*; D041623:Tomography, Optical Coherence / Q000379:methods*