Fibromyalgia in a Patient with Cushing's Disease Accompanied by Central Hypothyroidism.
A 39-year-old woman with a 3-year history of a rounded face developed widespread myalgia. Detailed examinations revealed no disorders that could explain the pain other than concomitant Cushing's disease and central hypothyroidism. Both the hypercortisolemia and hypothyroidism completely resolved after the patient underwent surgery to treat Cushing's disease, but she continued to experience unresolved myalgia and met the diagnostic criteria for fibromyalgia. Few studies have so far investigated patients with fibromyalgia associated with Cushing's syndrome. In our case, the hypothyroidism caused by Cushing's disease probably played an important role in triggering and exacerbating fibromyalgia. This highlights the need to examine the endocrine function in patients with muscle pain.
Department of Hematology, Endocrinology and Metabolism, Niigata University Faculty of Medicine, Japan.
Nobumasa
N
Ohara
Shinichi
S
Katada
Takaho
T
Yamada
Naomi
N
Mezaki
Hiroshi
H
Suzuki
Akiko
A
Suzuki
Osamu
O
Hanyu
Yuichiro
Y
Yoneoka
Izumi
I
Kawachi
Takayoshi
T
Shimohata
Akiyoshi
A
Kakita
Masatoyo
M
Nishizawa
Hirohito
H
Sone
D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D003937:Diagnosis, Differential; D005260:Female; D005356:Fibromyalgia / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007037:Hypothyroidism / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D047748:Pituitary ACTH Hypersecretion / Q000097:blood / Q000150:complications / Q000175:diagnosis* / Q000601:surgery
D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone