Diversity of killer cell immunoglobulin-like receptor genes in Drung Chinese.
Killer cell immunoglobulin-like receptor (KIR) genes are variably distributed among populations from distinct geographic areas and ethnic origins. We describe, for the first time, KIR gene diversity in 152 unrelated and healthy Drung individuals, as measured by sequence-specific polymerase chain reaction. All 16 known KIR genes were detected. Of these, the framework genes KIR2DL4, 3DL2, 3DL3, and 3DP1 were present in all individuals as expected, along with the non-framework genes KIR2DL1, 2DL3, and 2DP1. In contrast, KIR2DL2, 2DS2, and 2DS5 were unusually rare, suggesting that KIR gene distribution was relatively concentrated. Ten different KIR genotypes were found, of which the most common consisted of nine genes (KIR2DL1, 2DL3, 2DL4, 2DS4, 3DL1, 3DL2, 3DL3, 2DP1, and 3DP1) and accounted for 66.4% of participants. There were eight different haplotypes present, of which the A haplotype was the most common (81.9%). Principal components and dendrogram analysis confirmed that the Drung Chinese are most closely related to the Japanese, the Zhejiang Han, and the Yunnan Han. In conclusion, distinctive frequencies of KIR genes, haplotypes, and genotypes are observed in Chinese Drung.
Clinical Transfusion Research Center, Institute of Blood Transfusion, Chinese Academy of Medical Sciences and Peking Union Medical College, Chengdu, China.
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L
Jiang
Transfusion Medicine Research Department, Yunnan Kunming Blood Center, Yunnan Kunming, China.
P
P
Su
Transfusion Medicine Research Department, Yunnan Kunming Blood Center, Yunnan Kunming, China.
T
T
Yang
Transfusion Medicine Research Department, Yunnan Kunming Blood Center, Yunnan Kunming, China.
X
X
Zhu
Transfusion Medicine Research Department, Yunnan Kunming Blood Center, Yunnan Kunming, China.
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F
Yao
Transfusion Medicine Research Department, Yunnan Kunming Blood Center, Yunnan Kunming, China.
Z
Z
Che
Transfusion Medicine Research Department, Yunnan Kunming Blood Center, Yunnan Kunming, China.
H
H
Ma
Clinical Transfusion Research Center, Institute of Blood Transfusion, Chinese Academy of Medical Sciences and Peking Union Medical College, Chengdu, China.
J
J
Wang
Clinical Transfusion Research Center, Institute of Blood Transfusion, Chinese Academy of Medical Sciences and Peking Union Medical College, Chengdu, China.|HLA Typing Laboratory, Sichuan Cord Blood Bank, Chengdu, China.
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Q
Chen
KIR gene; ethnic minority Chinese; genotype; haplotype