Operating Procedures of the Electrochemotherapy for Treatment of Tumor in Dogs and Cats.
Electrochemotherapy (ECT) is a local approach which is used for treating solid tumors of different histologies. Its mechanism is based on cell membrane permeabilization by means of "electroporation". To achieve the "electroporation" of the cells, electric pulses are generated by a generator and delivered to the target tissue by the use of electrodes. Electroporation is a physical method which is used to introduce molecules, like cytostatic drugs, into the cells that could not pass the cell membrane on their own. In electrochemotherapy, currently, cisplatin and bleomycin are clinically used. Electrochemotherapy antitumor effectiveness is high, for example up to 100% complete response of canine mast cell tumors smaller than 2 cm3was achieved. Additionally, electrochemotherapy can be used for the treatment of inoperable tumors. One of the important characteristics of electrochemotherapy is that it can be effective as a one-time treatment only. However, in the case of failure or partial tumor response it can be repeated several times with equal or improved effectiveness. Electrochemotherapy is already a standard treatment for cutaneous and subcutaneous tumors of various histologies in human and veterinary oncology. Furthermore, several clinical studies exploiting electrochemotherapy for deep-seated tumors are on-going.
Clinic for Surgery and Small Animals, Veterinary Faculty, University of Ljubljana.
Natasa
N
Tozon
Department of Experimental Oncology, Institute of Oncology Ljubljana.
Ursa
U
Lampreht Tratar
Faculty of Health Sciences, University of Primorska.
Katarina
K
Znidar
Department of Experimental Oncology, Institute of Oncology Ljubljana.
Gregor
G
Sersa
IPBS (Institut de Pharmacologie et de Biologie Structurale), CNRS; IPBS (Institut de Pharmacologie et de Biologie Structurale), Université de Toulouse.
Justin
J
Teissie
Department of Experimental Oncology, Institute of Oncology Ljubljana; Faculty of Health Sciences, University of Primorska; mcemazar@onko-i.si.
Maja
M
Cemazar
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001761:Bleomycin / Q000627:therapeutic use; D002415:Cats; D002945:Cisplatin / Q000627:therapeutic use; D004285:Dogs; D053672:Electrochemotherapy; D018274:Electroporation; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000662:veterinary
D000970:Antineoplastic Agents; D001761:Bleomycin; D002945:Cisplatin