Highly Disordered Proteins in Prostate Cancer.
Prostate cancer is one of the major threats to the man's health. There are several mechanisms of the prostate cancer development characterized by the involvement of various androgen-related and androgen-unrelated factors in prostate cancer pathogenesis and in the metastatic carcinogenesis of prostate. In all these processes, proteins play various important roles, and the KEGG database has information on 88 human proteins experimentally shown to be involved in prostate cancer. It is known that many proteins associated with different human maladies are intrinsically disordered (i.e., they do not have stable secondary and/or tertiary structure in their unbound states). The goal of this review is to consider several highly disordered proteins known to be associated with the prostate cancer pathogenesis in order to better understand the roles of disordered proteins in this disease. We also hope that consideration of the pathology-related proteins from the perspective of intrinsic disorder can potentially lead to future experimental studies of these proteins to find novel pathways associated with prostate cancer.
VNU, Department of Molecular Medicine, University of South Florida, 12901 Bruce B. Downs Blvd. MDC07, Tampa, Florida 33612, FL. United States.
Vladimir N
VN
Uversky
Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612. United States.
Insung
I
Na
Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612. United States.
Kevin S
KS
Landau
Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612. United States.
Ryan O
RO
Schenck
D000595:Amino Acid Sequence; D015972:Gene Expression Regulation, Neoplastic; D053263:Gene Regulatory Networks; D006801:Humans; D064267:Intrinsically Disordered Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D008297:Male; D008958:Models, Molecular; D009363:Neoplasm Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D011487:Protein Conformation; D025941:Protein Interaction Mapping; D011499:Protein Processing, Post-Translational; D020543:Proteome / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid
D064267:Intrinsically Disordered Proteins; D009363:Neoplasm Proteins; D020543:Proteome
Intrinsically disordered proteins; posttranslational modifications; prostate cancer; protein-protein interaction; proteome; proteomics.