Oseltamivir for pandemic influenza preparation: Maximizing the use of an existing stockpile.
With the threat of significant morbidity and mortality following an influenza pandemic, stockpiling of antiviral agents such as oseltamivir is recommended. Shelf-life extension was explored to maximize use of an existing stockpile. This analysis demonstrated that oseltamivir retains potency defined by United States Pharmacopeia acceptance criteria beyond the labeled expiration date.
Pharmacy Services, University of Michigan Health System, Ann Arbor, MI.
Twisha S
TS
Patel
Infectious Diseases, University of Michigan Health System, Ann Arbor, MI.
Sandro
S
Cinti
University of Michigan College of Pharmacy, Ann Arbor, MI.
Duxin
D
Sun
University of Michigan College of Pharmacy, Ann Arbor, MI.
Siwei
S
Li
University of Michigan College of Pharmacy, Ann Arbor, MI.
Ruijuan
R
Luo
University of Michigan College of Pharmacy, Ann Arbor, MI.
Bo
B
Wen
Marshall University School of Pharmacy, Huntington, WV; Joan C. Edwards School of Medicine, Huntington, WV.
Brian A
BA
Gallagher
Pharmacy Services, University of Michigan Health System, Ann Arbor, MI; University of Michigan College of Pharmacy, Ann Arbor, MI. Electronic address: jimsteve@med.umich.edu.
James G
JG
Stevenson
D000998:Antiviral Agents / Q000494:pharmacology*; D002959:Civil Defense; D004355:Drug Stability; D006801:Humans; D007251:Influenza, Human / Q000188:drug therapy* / Q000453:epidemiology*; D053139:Oseltamivir / Q000494:pharmacology*; D058873:Pandemics; D062205:Strategic Stockpile; D014481:United States
D000998:Antiviral Agents; D053139:Oseltamivir