Memantine attenuates cognitive impairments after status epilepticus induced in a lithium-pilocarpine model.
The capability of memantine, a noncompetitive antagonist of the NMDA receptors, to prevent impairments of cognitive functions in rats was investigated in the lithium-pilocarpine model of epilepsy. After status epilepticus, rats exhibited impaired exploratory behavior and spatial memory, and a decline of extinction of orienting behavior. Memantine administration prevented these disturbances. Thus, the blockade of the NMDA receptors immediately after status epilepticus allowed prevention of the development of the possible cognitive impairments.
Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia.
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Kalemenev
Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia.|Institute of Experimental Medicine, St. Petersburg, Russia.
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OE
Zubareva
Institute of Experimental Medicine, St. Petersburg, Russia.
V V
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Sizov
Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia.
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Lavrent'eva
Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia.
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Lukomskaya
Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia.
K Kh
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Kim
Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia.
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Zaitsev
Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia. levmagazanik100@gmail.com.|St. Petersburg State University, St. Petersburg, Russia. levmagazanik100@gmail.com.
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Magazanik
D000818:Animals; D003071:Cognition / Q000187:drug effects; D060825:Cognitive Dysfunction / Q000139:chemically induced / Q000503:physiopathology* / Q000517:prevention & control*; D005106:Exploratory Behavior / Q000187:drug effects; D005108:Extinction, Psychological / Q000187:drug effects; D008094:Lithium; D008297:Male; D008559:Memantine / Q000008:administration & dosage*; D009949:Orientation / Q000187:drug effects; D010862:Pilocarpine; D051381:Rats; D017208:Rats, Wistar; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors* / Q000378:metabolism; D065852:Spatial Memory / Q000187:drug effects; D013226:Status Epilepticus / Q000139:chemically induced / Q000503:physiopathology* / Q000517:prevention & control*; D016896:Treatment Outcome
D016194:Receptors, N-Methyl-D-Aspartate; D010862:Pilocarpine; D008094:Lithium; D008559:Memantine