New Approaches to Investigate Drug-Induced Hypersensitivity.
The workshop on "New Approaches to Investigate Drug-Induced Hypersensitivity" was held on June 5, 2014 at the Foresight Center, University of Liverpool. The aims of the workshop were to (1) discuss our current understanding of the genetic, clinical, and chemical basis of small molecule drug hypersensitivity, (2) highlight the current status of assays that might be developed to predict potential drug immunogenicity, and (3) identify the limitations, knowledge gaps, and challenges that limit the use of these assays and utilize the knowledge gained from the workshop to develop a pathway to establish new and improved assays that better predict drug-induced hypersensitivity reactions during the early stages of drug development. This perspective reviews the clinical and immunological bases of drug hypersensitivity and summarizes various experts' views on the different topics covered during the meeting.
Pathology Sciences, Drug Safety and Metabolism, AstraZeneca R&D , Darwin Building 310, Cambridge Science Park, Milton Road, Cambridge CB4 0WG, U.K.|MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool , Ashton Street, Liverpool L69 3GE, U.K.
Monday O
MO
Ogese
Alcyomics Ltd c/o Haematological Sciences, Institute of Cellular Medicine, Newcastle University , Newcastle upon Tyne NE2 4HH, U.K.
Shaheda
S
Ahmed
MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool , Ashton Street, Liverpool L69 3GE, U.K.
Ana
A
Alferivic
Pathology Sciences, Drug Safety and Metabolism, AstraZeneca R&D , Darwin Building 310, Cambridge Science Park, Milton Road, Cambridge CB4 0WG, U.K.
Catherine J
CJ
Betts
Alcyomics Ltd c/o Haematological Sciences, Institute of Cellular Medicine, Newcastle University , Newcastle upon Tyne NE2 4HH, U.K.
Anne
A
Dickinson
MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool , Ashton Street, Liverpool L69 3GE, U.K.
Lee
L
Faulkner
MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool , Ashton Street, Liverpool L69 3GE, U.K.
Neil
0000-0002-9376-3482
N
French
MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool , Ashton Street, Liverpool L69 3GE, U.K.
Andrew
A
Gibson
Centre for Liver Research, NIHR Birmingham Liver Biomedical Research Unit, Institute of Immunology and Immunotherapy, University of Birmingham , Edgbaston, Birmingham B15 2TT, U.K.
Gideon M
GM
Hirschfield
Novartis Institutes for Biomedical Research , Klybeckstrasse 141, CH-4057 Basel, Switzerland.
Michael
M
Kammüller
MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool , Ashton Street, Liverpool L69 3GE, U.K.
Xiaoli
0000-0002-7774-2075
X
Meng
Department of Dermatology and Venereology, Allergy Research Group, University of Freiburg , Hauptstraße 7, 79104 Freiburg, Germany.
Stefan F
SF
Martin
Department of Dermatology and INSERM, University of Rouen , 905 Rouen, France.
Philippe
P
Musette
MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool , Ashton Street, Liverpool L69 3GE, U.K.
Alan
A
Norris
MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool , Ashton Street, Liverpool L69 3GE, U.K.|The Wolfson Centre for Personalised Medicine, Department of Molecular and Clinical Pharmacology, University of Liverpool , Ashton Street, Liverpool L69 3GE, U.K.
Munir
M
Pirmohamed
MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool , Ashton Street, Liverpool L69 3GE, U.K.
B Kevin
BK
Park
Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University , Clayton, Victoria 3800, Australia.
Anthony W
0000-0003-0532-8331
AW
Purcell
Medicines Research Centre, GlaxoSmithKline , Gunnels Wood Road, Stevenage SG1 2NY, U.K.
Colin F
CF
Spraggs
Drug Safety Research and Development, Pfizer , Eastern Point Road, Groton, Connecticut 06340, United States.
Jessica
J
Whritenour
MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool , Ashton Street, Liverpool L69 3GE, U.K.
Dean J
DJ
Naisbitt
D000818:Animals; D001681:Biological Assay; D004342:Drug Hypersensitivity / Q000235:genetics / Q000276:immunology; D004345:Drug Industry; D020022:Genetic Predisposition to Disease; D006801:Humans; D008285:Major Histocompatibility Complex / Q000276:immunology; D010641:Phenotype; D012307:Risk Factors