Effect of Long-Term Administration of Nicorandil on Endothelial Function of the Radial Artery in Patients With Angina Undergoing Transradial Percutaneous Coronary Intervention.
We evaluated the effect of long-term administration of nicorandil on endothelial function of the radial artery in patients with angina undergoing elective transradial coronary intervention (TRI). A total of 127 patients were randomly assigned to nicorandil (standard medication plus nicorandil 5 mg twice daily, n = 64) or control group (standard medication except nicorandil, n = 63) immediately after TRI procedure. Radial artery diameter (RAD), flow-mediated dilation (FMD), and nitroglycerin-mediated dilation (NMD) of radial artery were measured 1 day before TRI as well as 1 day and 3 months after TRI by Ultrasound-Doppler. No significant difference was observed in the baseline RAD, FMD, and NMD between the 2 groups (all P > .05). In cannulated arm, at 3-month follow-up, RAD in nicorandil group was much larger than that in the control group (2.78 ± 0.27 mm vs 2.61 ± 0.30 mm, P = .001). Besides, FMD and NMD were much higher in nicorandil group than those in the control group (10.38% ± 2.43% vs 6.81% ± 1.86%; 15.94% ± 6.28% vs 10.46% ± 5.37%, respectively, all Ps < .001). In conclusion, long-term administration of nicorandil after TRI could improve the endothelial function of the cannulated radial artery.
1 Department of Cardiology, Second Hospital of Hebei Medical University, Shijiazhuang, People's Republic of China.
Yanming
Y
Fan
1 Department of Cardiology, Second Hospital of Hebei Medical University, Shijiazhuang, People's Republic of China.
Xianghua
X
Fu
1 Department of Cardiology, Second Hospital of Hebei Medical University, Shijiazhuang, People's Republic of China.
Yanbo
Y
Wang
1 Department of Cardiology, Second Hospital of Hebei Medical University, Shijiazhuang, People's Republic of China.
Wei
W
Li
1 Department of Cardiology, Second Hospital of Hebei Medical University, Shijiazhuang, People's Republic of China.
Xile
X
Bi
1 Department of Cardiology, Second Hospital of Hebei Medical University, Shijiazhuang, People's Republic of China.
Liye
L
Wei
1 Department of Cardiology, Second Hospital of Hebei Medical University, Shijiazhuang, People's Republic of China.
Yuyang
Y
Xiao
1 Department of Cardiology, Second Hospital of Hebei Medical University, Shijiazhuang, People's Republic of China.
Shiru
S
Bai
D000368:Aged; D000369:Aged, 80 and over; D000787:Angina Pectoris / Q000188:drug therapy*; D000792:Angiography / Q000379:methods; D042783:Endothelial Cells / Q000187:drug effects*; D005260:Female; D006321:Heart / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D020108:Nicorandil / Q000627:therapeutic use*; D005996:Nitroglycerin / Q000627:therapeutic use; D062645:Percutaneous Coronary Intervention / Q000379:methods; D017534:Radial Artery / Q000187:drug effects*; D013995:Time
D020108:Nicorandil; D005996:Nitroglycerin
endothelial function; flow-mediated dilation; nicorandil; nitroglycerin-mediated dilation; radial artery diameter; transradial coronary intervention