The Protein Data Bank: Current Status and Future Challenges.
The Protein Data Bank (PDB) is an archive of experimentally determined three-dimensional structures of proteins, nucleic acids, and other biological macromolecules with a 25 year history of service to a global community. PDB is being replaced by 3DB, the Three-Dimensional Database of Biomolecular Structures that will continue to operate from Brookhaven National Laboratory. 3DB will be a highly sophisticated knowledge-based system for archiving and accessing structural information that combines the advantages of object oriented and relational database systems. 3DB will operate as a direct-deposition archive that will also accept third-party supplied annotations. Conversion of PDB to 3DB will be evolutionary, providing a high degree of compatibility with existing software.
Department of Chemistry, Brookhaven National Laboratory, Upton, NY 11973 USA.
Enrique E
EE
Abola
Department of Chemistry, Brookhaven National Laboratory, Upton, NY 11973 USA.
Nancy O
NO
Manning
BioInformatics Unit, Weizmann Institute of Science, Rehovot 76100 Israel.
Jaime
J
Prilusky
Department of Chemistry, Brookhaven National Laboratory, Upton, NY 11973 USA.
David R
DR
Stampf
BioInformatics Unit, and the Department of Structural Biology, Weizmann Institute of Science, Rehovot 76100 Israel.
Joel L
JL
Sussman
NMR; database; federation; protein structure; three-dimensional structure; x-ray crystallography