Unraveling the Anticancer Effect of Curcumin and Resveratrol.
Resveratrol and curcumin are natural products with important therapeutic properties useful to treat several human diseases, including cancer. In the last years, the number of studies describing the effect of both polyphenols against cancer has increased; however, the mechanism of action in all of those cases is not completely comprehended. The unspecific effect and the ability to interfere in assays by both polyphenols make this challenge even more difficult. Herein, we analyzed the anticancer activity of resveratrol and curcumin reported in the literature in the last 11 years, in order to unravel the molecular mechanism of action of both compounds. Molecular targets and cellular pathways will be described. Furthermore, we also discussed the ability of these natural products act as chemopreventive and its use in association with other anticancer drugs.
School of Pharmaceutical Sciences, UNESP-Univ Estadual Paulista, Araraquara 14800903, Brazil. alinerenatapavan2004@yahoo.com.br.
Aline Renata
AR
Pavan
School of Pharmaceutical Sciences, UNESP-Univ Estadual Paulista, Araraquara 14800903, Brazil. gabriel.dalio@hotmail.com.
Gabriel Dalio Bernardes da
GD
Silva
School of Pharmaceutical Sciences, UNESP-Univ Estadual Paulista, Araraquara 14800903, Brazil. daniela.hj@hotmail.com.
Daniela Hartmann
DH
Jornada
School of Pharmaceutical Sciences, UNESP-Univ Estadual Paulista, Araraquara 14800903, Brazil. chiba.diego@outlook.com.
Diego Eidy
DE
Chiba
School of Pharmaceutical Sciences, UNESP-Univ Estadual Paulista, Araraquara 14800903, Brazil. guilhermefelipe@outlook.com.
Guilherme Felipe Dos Santos
GF
Fernandes
School of Pharmaceutical Sciences, UNESP-Univ Estadual Paulista, Araraquara 14800903, Brazil. chungmc@fcfar.unesp.br.
Chung
C
Man Chin
School of Pharmaceutical Sciences, UNESP-Univ Estadual Paulista, Araraquara 14800903, Brazil. santosjl@fcfar.unesp.br.
Jean Leandro
JL
Dos Santos
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D003474:Curcumin / Q000494:pharmacology*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology*
D000972:Antineoplastic Agents, Phytogenic; D013267:Stilbenes; D003474:Curcumin; D000077185:Resveratrol
anticancer; cancer; curcumin; polyphenols; resveratrol