MIS12/MIND Control at the Kinetochore.
Kinetochores are complex multiprotein machines that link chromosomes to dynamic microtubules for chromosome segregation. Two studies in Cell reveal the structure of the human MIS12 and budding yeast MIND kinetochore complexes and the regulatory mechanisms that enable them to link chromosomes to microtubules during mitosis.
Department of Biochemistry, Stanford University, Stanford, CA 94305, USA.
Rene
R
Ladurner
Department of Biochemistry, Stanford University, Stanford, CA 94305, USA. Electronic address: astraigh@stanford.edu.
Aaron F
AF
Straight
D020090:Chromosome Segregation; D006801:Humans; D018386:Kinetochores; D008870:Microtubules / Q000737:chemistry; D008938:Mitosis