Tackling Difficult Staphylococcus aureus Infections: Antibodies Show the Way.
The recent spread of community-acquired methicillin-resistant Staphylococcus aureus (MRSA) has brought increasing concerns of heightened disease severity and persistence following invasive disease. In line with the need for new treatment paradigms, two recent reports have shown that antibody-based therapies can restrict acute S. aureus infection and persistence and improve pathological symptoms.
Department of Microbiology, New York University School of Medicine, New York, NY 10016, USA; Division of Infectious Diseases, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA.
Bo
B
Shopsin
Institut National de la Santé et de la Recherche Médicale Unité 1138, Paris 75006, France; Sorbonne Universités, UPMC Univ Paris 06, UMR S 1138, Paris 75006, France; Université Paris Descartes, Sorbonne Paris Cité, UMR S 1138, Paris 75006, France; Centre de Recherche des Cordeliers, Equipe - Immunopathologie et immuno-intervention thérapeutique, Paris 75006, France.
Srini V
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Kaveri
Institut National de la Santé et de la Recherche Médicale Unité 1138, Paris 75006, France; Sorbonne Universités, UPMC Univ Paris 06, UMR S 1138, Paris 75006, France; Université Paris Descartes, Sorbonne Paris Cité, UMR S 1138, Paris 75006, France; Centre de Recherche des Cordeliers, Equipe - Immunopathologie et immuno-intervention thérapeutique, Paris 75006, France. Electronic address: jagadeesh.bayry@crc.jussieu.fr.
Jagadeesh
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Bayry
D001427:Bacterial Toxins; D017714:Community-Acquired Infections; D005098:Exotoxins; D006801:Humans; D007956:Leukocidins; D055624:Methicillin-Resistant Staphylococcus aureus; D013203:Staphylococcal Infections; D013211:Staphylococcus aureus
D001427:Bacterial Toxins; D005098:Exotoxins; D007956:Leukocidins
IVIG; Immunoglobulin; Panton-Valentine leukocidin; Thiomab; antibiotic; intravenous immunoglobulin; necrotizing pneumonia; phagocytes; rifalogue; α-hemolysin