title: Efficiacy of resveratrol and quercetin after experimental spinal cord injury.
abstract: BACKGROUND
  The aim of this study was to investigate the effect of natural antioxidants resveratrol and quercetin on oxidative stress and secondary cell damage in rats with acute spinal cord injury.
  
  
  METHODS
  In this experimental study, 42 male Sprague-Dawley rats were used. Spinal cord injury was performed with clip compression method at level of T4-5. The study was conducted using 6 groups: control, trauma, trauma and solvent, trauma and resveratrol, trauma and quercetin, and trauma with combined resveratrol and quercetin. All rats were euthanized 48 hours after the procedure. Effects of resveratrol and quercetin on serum and tissue total antioxidant capacity and paraoxanase activity level were examined.
  
  
  RESULTS
  Compared to trauma group, there was a significant increase in total antioxidant capacity and paraoxanase activity level in resveratrol, quercetin, and combined treatment groups. There was no significant difference between resveratrol and quercetin groups with regard to total antioxidant capacity and paraoxanase activity level. Total antioxidant capacity and paraoxanase activity level were significantly higher in solvent group than trauma group. In histopathological evaluation, there was a decrease in polymorphonuclear leukocyte infiltration in solvent, resveratrol, quercetin, and combined treatment groups.
  
  
  CONCLUSIONS
  Biochemical and histological staining results of present study showed that resveratrol and quercetin may be effective in preventing secondary damage in spinal cord injury.
authors.affiliation: Department of Neurosurgery, Bakırköy Dr. Sadi Konuk Training and Research Hospital, İstanbul-Turkey. drulvi26@hotmail.com.
authors.forename: Ulvi
authors.initials: U
authors.lastname: Çiftçi
authors.affiliation: Department of Neurosurgery, Trakya University Faculty of Medicine, Edirne-Turkey.
authors.forename: Emre
authors.initials: E
authors.lastname: Delen
authors.affiliation: Department of Neurosurgery, Eskişehir Osmangazi University Faculty of Medicine, Eskişehir-Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Vural
authors.affiliation: Department of Histology, Eskişehir Osmangazi University Faculty of Medicine, Eskişehir-Turkey.
authors.forename: Onur
authors.initials: O
authors.lastname: Uysal
authors.affiliation: Department of Medical Biology, Eskişehir Osmangazi University Faculty of Medicine, Eskişehir-Turkey.
authors.forename: Didem
authors.initials: D
authors.lastname: Turgut Coşan
authors.affiliation: Department of Biostatistics, Kocaeli University Faculty of Medicine, Kocaeli-Turkey.
authors.forename: Canan
authors.initials: C
authors.lastname: Baydemir
authors.affiliation: Department of Medical Biology, Eskişehir Osmangazi University Faculty of Medicine, Eskişehir-Turkey.
authors.forename: Fulya
authors.initials: F
authors.lastname: Doğaner
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000627:therapeutic use*; D004195:Disease Models, Animal; D007249:Inflammation; D008297:Male; D018384:Oxidative Stress; D011794:Quercetin / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D000077185:Resveratrol; D013119:Spinal Cord Injuries / Q000473:pathology / Q000517:prevention & control*; D013267:Stilbenes / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D000975:Antioxidants; D013267:Stilbenes; D011794:Quercetin; D000077185:Resveratrol