title: Is a cause of postpartum hemorrhage of using of tocolytic agents in preterm delivery?
abstract: OBJECTIVE
  Tocolytic agents are used to inhibit uterine contraction in preterm. The authors undertook this study to determine whether using of tocolytic agents before delivery is associated with increase postpartum hemorrhage in preterm delivered women.
  
  
  METHODS
  296 singleton pregnancies delivered preterm from 24 + 1 to 37 + 0 weeks gestation were retrospectively reviewed. Hemoglobin (HB) and hematocrit (HCT) levels were checked before and after delivery to access postpartum blood loss. Multivariate logistic regression analysis was performed to determine whether delivery within the half-lives of tocolytic agents was associated with decreased HB and HCT levels.
  
  
  RESULTS
  After adjusting for maternal age, parity, gestational age at delivery, birth weight, delivery method, and induction of labor, postpartum HB and HCT levels of those delivered within half-lives of tocolytic agents were found to be significantly diminished (HB: OR 3.306, 1.308-8.356 95% CI, p = 0.011; HCT: OR 2.692, 1.077-6.726 95% CI, p = 0.034). In addition, blood transfusion rates were elevated for deliveries made within the half-lives of tocolytic agents, (p = 0.006).
  
  
  CONCLUSIONS
  Delivery within half-lives of tocolytic agents was found to be associated with low HB and HCT levels after delivery and higher blood transfusion rates in preterm delivered women.
authors.affiliation: a Department of Obstetrics and Gynecology , Inha University School of Medicine, Inha University Hospital , Incheon , South Korea.
authors.forename: Soo Ran
authors.initials: SR
authors.lastname: Choi
authors.affiliation: a Department of Obstetrics and Gynecology , Inha University School of Medicine, Inha University Hospital , Incheon , South Korea.
authors.forename: Nae Ri
authors.initials: NR
authors.lastname: Yoon
authors.affiliation: a Department of Obstetrics and Gynecology , Inha University School of Medicine, Inha University Hospital , Incheon , South Korea.
authors.forename: Sung Ook
authors.initials: SO
authors.lastname: Hwang
mesh_terms: D000328:Adult; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007752:Obstetric Labor, Premature / Q000188:drug therapy* / Q000453:epidemiology; D006473:Postpartum Hemorrhage / Q000453:epidemiology / Q000209:etiology*; D011247:Pregnancy; D047928:Premature Birth / Q000188:drug therapy / Q000453:epidemiology; D012189:Retrospective Studies; D012307:Risk Factors; D015149:Tocolytic Agents / Q000627:therapeutic use*; D055815:Young Adult
chemical_list: D015149:Tocolytic Agents
keywords: Tocolytics; postpartum hemorrhage; preterm