title: Simultaneous determination of haloanisoles and halophenols in water using in situ acylation combined with solid-phase microextraction with gas chromatography and mass spectrometry.
abstract: In this work, an in situ acylation combined with solid-phase microextraction coupled to gas chromatography and mass spectrometry method has been developed for simultaneously determining haloanisoles (2,4,6-trichloranisole, 2,4,6-tribromoanisole), and their direct precursors (2,4,6-trichlorophenol, 2,4,6-tribromophenol) and indirect precursors (2-chloropenol, 2,4-dichlorophenol, 2-bromophenol, 2,4-dibromophenol) in water. The key parameters for the solid-phase microextraction were determined by using Plackett-Burman screening and optimized by central composite optimization. Under optimal conditions, the eight compounds can be analyzed in a short time (33 min) with a strong linearity ranging from 2 to 200 ng/L (correlation coefficient greater than 0.996), showing good sensitivities with the limit of detection in a range of 0.23-0.91 ng/L and a limit of quantification of 0.77-3.03 ng/L, good repeatability (2.00-9.10%) and interday precision (1.67-11.3%). When environmental water samples were treated, the recoveries of target compounds were 75.5-127.3%, suggesting that the developed method could be applied in probing the origin of haloanisoles and monitoring halophenols and haloanisoles in natural waters at concentration levels of ng/L.
authors.affiliation: Center for Environment and Water Resources, College of Chemistry and Chemical Engineering, Central South University, Changsha, P.R. China.
authors.forename: Chaoyi
authors.initials: C
authors.lastname: Wang
authors.affiliation: Center for Environment and Water Resources, College of Chemistry and Chemical Engineering, Central South University, Changsha, P.R. China.
authors.forename: Pan
authors.initials: P
authors.lastname: Zou
authors.affiliation: Center for Environment and Water Resources, College of Chemistry and Chemical Engineering, Central South University, Changsha, P.R. China.
authors.forename: Ting
authors.initials: T
authors.lastname: Zhang
authors.affiliation: Center for Environment and Water Resources, College of Chemistry and Chemical Engineering, Central South University, Changsha, P.R. China.
authors.forename: Haipu
authors.initials: H
authors.lastname: Li
authors.affiliation: Center for Environment and Water Resources, College of Chemistry and Chemical Engineering, Central South University, Changsha, P.R. China.|Shenzhen Research Institute of Central South University, B406 Virtual University, Shenzhen High-tech Industrial Park, Shenzhen, Guangdong, P.R. China.
authors.forename: Zhaoguang
authors.initials: Z
authors.lastname: Yang
keywords: acylation; central composite optimization; haloanisoles; halophenols; solid-phase microextraction