title: Febuxostat hypersensitivity: another cause of DRESS syndrome in chronic kidney disease?
abstract: Febuxostat is a xanthine oxidase inhibitor that during the last years has successfully replaced allopurinol treatment in patients with chronic kidney disease (CKD) and hyperuricemia. Several adverse events have been observed during therapy with febuxostat. DRESS (Drug Reaction with Eosinophilia and Systemic Symptoms) syndrome induced by febuxostat has been poorly described, mainly in patient with CKD who previously developed allopurinol hypersensitivity syndrome. DRESS syndrome is characterized by manifold cutaneous reactions and systemic disorders with potential devastating consequences. The underlying pathogenetic mechanisms remain unidentified, though immune responses are often complicated. P-i concept can partially explain the phenomenon. The role of renal insufficiency appears to be crucial and further investigation is required. The present article describes the case of a CKD patient that developed febuxostat-related DRESS syndrome.
authors.affiliation: Department of General Practice and Family Medicine, General Hospital of Pella, Edessa, Greece. E-mail: el_paschou@yahoo.gr.
authors.forename: E
authors.initials: E
authors.lastname: Paschou
authors.affiliation: Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
authors.forename: E
authors.initials: E
authors.lastname: Gavriilaki
authors.affiliation: Hematology Department and Hematopoietic Cell Transplantation (HCT) Unit, G. Papanikolaou Hospital, Thessaloniki, Greece.
authors.forename: G
authors.initials: G
authors.lastname: Papaioannou
authors.affiliation: Hematology Department and Hematopoietic Cell Transplantation (HCT) Unit, G. Papanikolaou Hospital, Thessaloniki, Greece.
authors.forename: A
authors.initials: A
authors.lastname: Tsompanakou
authors.affiliation: Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
authors.forename: A
authors.initials: A
authors.lastname: Kalaitzoglou
authors.affiliation: Department of Nephrology, General Hospital of Pella, Edessa, Greece.
authors.forename: N
authors.initials: N
authors.lastname: Sabanis
mesh_terms: D063926:Drug Hypersensitivity Syndrome / Q000209:etiology*; D000069465:Febuxostat / Q000009:adverse effects*; D006074:Gout Suppressants / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D051436:Renal Insufficiency, Chronic / Q000188:drug therapy
chemical_list: D006074:Gout Suppressants; D000069465:Febuxostat
keywords: DRESS; chronic kidney disease; febuxostat