title: Systemic hypersensitivity to fosaprepitant - A report of two cases.
abstract: Fosaprepitant is a widely administered antiemetic used mainly for moderately to highly emetogenic chemotherapy. Local injection site reactions are the most common type of infusion reaction reported from fosaprepitant. At our institution, two separate patients have experienced systemic hypersensitivity reactions to their infusions of fosaprepitant. We report a review of the literature and the details of these reactions.
authors.affiliation: 1 Stephenson Cancer Center, OK, USA.
authors.forename: Allison
authors.initials: A
authors.lastname: Baxley
authors.affiliation: 2 College of Pharmacy, University of Oklahoma, OK, USA.
authors.forename: Zoe
authors.initials: Z
authors.lastname: Lee
authors.affiliation: 2 College of Pharmacy, University of Oklahoma, OK, USA.
authors.forename: Patrick
authors.initials: P
authors.lastname: Medina
mesh_terms: D000328:Adult; D000932:Antiemetics / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009025:Morpholines / Q000009:adverse effects*
chemical_list: D000932:Antiemetics; D009025:Morpholines; C579707:fosaprepitant
keywords: Fosaprepitant; anaphylaxis; hypersensitivity; infusion reaction