title: Carbetocin for prevention of postcesarean hemorrhage in women with severe preeclampsia: a before-after cohort comparison with oxytocin.
abstract: OBJECTIVE
  The aim of the study was to compare the incidence of the use of additional uterotonics before and after the change of carbetocin to oxytocin for the prevention of postpartum hemorrhage after cesarean delivery in women with severe preeclampsia.
  
  
  METHODS
  This was an observational retrospective before-and-after study.
  
  
  METHODS
  Operating room, postoperative recovery area.
  
  
  METHODS
  Sixty women with severe preeclampsia undergoing cesarean delivery under spinal anesthesia; American Society of Anesthesiologists 3.
  
  
  METHODS
  Observational study.
  
  
  METHODS
  Blood pressure, heart rate, and biological data (hemoglobin, platelets, haptoglobin, prothrombin time index, activated partial thromboplastin time ratio, blood uric acid, aspartate aminotransferase, alanine aminotransferase, serum urea, serum creatinine, and albumin).
  
  
  RESULTS
  The incidence of additional uterotonic administration in the carbetocin and oxytocin groups was 15% and 10%, respectively (P=.70).
  
  
  CONCLUSIONS
  As carbetocin appears to be as effective and safe as oxytocin in preeclamptic women, its advantages make it a good uterotonic option in this particular setting.
authors.affiliation: Division of Anesthesiology, Pain, Emergency and Critical Care Medicine, Caremeau University Hospital, Nîmes, France. Electronic address: bastiannucci@gmail.com.
authors.forename: B
authors.initials: B
authors.lastname: Nucci
authors.affiliation: Division of Anesthesiology, Pain, Emergency and Critical Care Medicine, Caremeau University Hospital, Nîmes, France.
authors.forename: Agm
authors.initials: A
authors.lastname: Aya
authors.affiliation: Division of Anesthesiology, Pain, Emergency and Critical Care Medicine, Caremeau University Hospital, Nîmes, France.
authors.forename: E
authors.initials: E
authors.lastname: Aubry
authors.affiliation: Division of Anesthesiology, Pain, Emergency and Critical Care Medicine, Caremeau University Hospital, Nîmes, France.
authors.forename: J
authors.initials: J
authors.lastname: Ripart
mesh_terms: D000328:Adult; D000775:Anesthesia, Spinal; D002585:Cesarean Section / Q000009:adverse effects*; D057915:Drug Substitution; D005260:Female; D006801:Humans; D010120:Oxytocics / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D010121:Oxytocin / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D006473:Postpartum Hemorrhage / Q000517:prevention & control*; D011225:Pre-Eclampsia / Q000188:drug therapy*; D011247:Pregnancy; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D010120:Oxytocics; D010121:Oxytocin; C020731:carbetocin
keywords: Carbetocin; Cesarean; Oxytocin; Postpartum hemorrhage; Preeclampsia