title: One-Year Outcomes After Transcatheter Insertion of an Interatrial Shunt Device for the Management of Heart Failure With Preserved Ejection Fraction.
abstract: Heart failure with preserved ejection fraction has a complex pathophysiology and remains a therapeutic challenge. Elevated left atrial pressure, particularly during exercise, is a key contributor to morbidity and mortality. Preliminary analyses have demonstrated that a novel interatrial septal shunt device that allows shunting to reduce the left atrial pressure provides clinical and hemodynamic benefit at 6 months. Given the chronicity of heart failure with preserved ejection fraction, evidence of longer-term benefit is required.
  
  
  
  Patients (n=64) with left ventricular ejection fraction ≥40%, New York Heart Association class II-IV, elevated pulmonary capillary wedge pressure (≥15 mm Hg at rest or ≥25 mm Hg during supine bicycle exercise) participated in the open-label study of the interatrial septal shunt device. One year after interatrial septal shunt device implantation, there were sustained improvements in New York Heart Association class (P<0.001), quality of life (Minnesota Living with Heart Failure score, P<0.001), and 6-minute walk distance (P<0.01). Echocardiography showed a small, stable reduction in left ventricular end-diastolic volume index (P<0.001), with a concomitant small stable increase in the right ventricular end-diastolic volume index (P<0.001). Invasive hemodynamic studies performed in a subset of patients demonstrated a sustained reduction in the workload corrected exercise pulmonary capillary wedge pressure (P<0.01). Survival at 1 year was 95%, and there was no evidence of device-related complications.
  
  
  
  These results provide evidence of safety and sustained clinical benefit in heart failure with preserved ejection fraction patients 1 year after interatrial septal shunt device implantation. Randomized, blinded studies are underway to confirm these observations.
  
  
  
  URL: https://www.clinicaltrials.gov. Unique identifier: NCT01913613.
authors.affiliation: Department of Cardiology, Alfred Hospital, Melbourne, Victoria, Australia (D.M.K., A.W.); Georg-August Universität, Gottingen, Germany (G.H.); Na Homolce Hospital, Prague, Czech Republic (P.N.); St Antonius Ziekenhuis, Nieuwegein, The Netherlands (M.C.P.); University of Auckland, New Zealand (R.D.); CHU de Nantes, France (J.-N.T.); Fourth Military Hospital, Wroclaw, Poland (A.K.); Universität Klinikum Dusseldorf, Germany (R.W.); Cardiovascular Center Aalst, Belgium (M.P.); University Medical Center Schleswig-Holstein, Kiel, Germany (M.R.); Department of Cardiology, St Vincent's Hospital, Sydney, New South Wales, Australia (D.M., C.H.); Department of Cardiology, Prince Charles Hospital, Brisbane, Queensland, Australia (D.W.); Klinikum Großhadern, Munich, Germany (J.H.); Internal Medicine, University of Heidelberg, Germany (P.R.); Golden Jubilee Hospital, Glasgow, Great Britain (M.C.P.); Cardiologicum Hamburg, Germany (M.B.); Bichat Hospital, INSERM, Paris, France (G.J.); Northshore University Health System, Evanston, IL (T.F.); University Medical Centre, Groningen, Netherlands (D.J.v.V.); Wroclaw Medical University, Czech Republic (P.P.); Hospital of the University of Pennsylvania, Philadelphia (F.E.S.); and Columbia University, New York, NY (D.B.). david.kaye@bakeridi.edu.au.
authors.forename: David M
authors.initials: DM
authors.lastname: Kaye
authors.affiliation: Department of Cardiology, Alfred Hospital, Melbourne, Victoria, Australia (D.M.K., A.W.); Georg-August Universität, Gottingen, Germany (G.H.); Na Homolce Hospital, Prague, Czech Republic (P.N.); St Antonius Ziekenhuis, Nieuwegein, The Netherlands (M.C.P.); University of Auckland, New Zealand (R.D.); CHU de Nantes, France (J.-N.T.); Fourth Military Hospital, Wroclaw, Poland (A.K.); Universität Klinikum Dusseldorf, Germany (R.W.); Cardiovascular Center Aalst, Belgium (M.P.); University Medical Center Schleswig-Holstein, Kiel, Germany (M.R.); Department of Cardiology, St Vincent's Hospital, Sydney, New South Wales, Australia (D.M., C.H.); Department of Cardiology, Prince Charles Hospital, Brisbane, Queensland, Australia (D.W.); Klinikum Großhadern, Munich, Germany (J.H.); Internal Medicine, University of Heidelberg, Germany (P.R.); Golden Jubilee Hospital, Glasgow, Great Britain (M.C.P.); Cardiologicum Hamburg, Germany (M.B.); Bichat Hospital, INSERM, Paris, France (G.J.); Northshore University Health System, Evanston, IL (T.F.); University Medical Centre, Groningen, Netherlands (D.J.v.V.); Wroclaw Medical University, Czech Republic (P.P.); Hospital of the University of Pennsylvania, Philadelphia (F.E.S.); and Columbia University, New York, NY (D.B.).
authors.forename: Gerd
authors.initials: G
authors.lastname: Hasenfuß
authors.affiliation: Department of Cardiology, Alfred Hospital, Melbourne, Victoria, Australia (D.M.K., A.W.); Georg-August Universität, Gottingen, Germany (G.H.); Na Homolce Hospital, Prague, Czech Republic (P.N.); St Antonius Ziekenhuis, Nieuwegein, The Netherlands (M.C.P.); University of Auckland, New Zealand (R.D.); CHU de Nantes, France (J.-N.T.); Fourth Military Hospital, Wroclaw, Poland (A.K.); Universität Klinikum Dusseldorf, Germany (R.W.); Cardiovascular Center Aalst, Belgium (M.P.); University Medical Center Schleswig-Holstein, Kiel, Germany (M.R.); Department of Cardiology, St Vincent's Hospital, Sydney, New South Wales, Australia (D.M., C.H.); Department of Cardiology, Prince Charles Hospital, Brisbane, Queensland, Australia (D.W.); Klinikum Großhadern, Munich, Germany (J.H.); Internal Medicine, University of Heidelberg, Germany (P.R.); Golden Jubilee Hospital, Glasgow, Great Britain (M.C.P.); Cardiologicum Hamburg, Germany (M.B.); Bichat Hospital, INSERM, Paris, France (G.J.); Northshore University Health System, Evanston, IL (T.F.); University Medical Centre, Groningen, Netherlands (D.J.v.V.); Wroclaw Medical University, Czech Republic (P.P.); Hospital of the University of Pennsylvania, Philadelphia (F.E.S.); and Columbia University, New York, NY (D.B.).
authors.forename: Petr
authors.initials: P
authors.lastname: Neuzil
authors.affiliation: Department of Cardiology, Alfred Hospital, Melbourne, Victoria, Australia (D.M.K., A.W.); Georg-August Universität, Gottingen, Germany (G.H.); Na Homolce Hospital, Prague, Czech Republic (P.N.); St Antonius Ziekenhuis, Nieuwegein, The Netherlands (M.C.P.); University of Auckland, New Zealand (R.D.); CHU de Nantes, France (J.-N.T.); Fourth Military Hospital, Wroclaw, Poland (A.K.); Universität Klinikum Dusseldorf, Germany (R.W.); Cardiovascular Center Aalst, Belgium (M.P.); University Medical Center Schleswig-Holstein, Kiel, Germany (M.R.); Department of Cardiology, St Vincent's Hospital, Sydney, New South Wales, Australia (D.M., C.H.); Department of Cardiology, Prince Charles Hospital, Brisbane, Queensland, Australia (D.W.); Klinikum Großhadern, Munich, Germany (J.H.); Internal Medicine, University of Heidelberg, Germany (P.R.); Golden Jubilee Hospital, Glasgow, Great Britain (M.C.P.); Cardiologicum Hamburg, Germany (M.B.); Bichat Hospital, INSERM, Paris, France (G.J.); Northshore University Health System, Evanston, IL (T.F.); University Medical Centre, Groningen, Netherlands (D.J.v.V.); Wroclaw Medical University, Czech Republic (P.P.); Hospital of the University of Pennsylvania, Philadelphia (F.E.S.); and Columbia University, New York, NY (D.B.).
authors.forename: Martijn C
authors.initials: MC
authors.lastname: Post
authors.affiliation: Department of Cardiology, Alfred Hospital, Melbourne, Victoria, Australia (D.M.K., A.W.); Georg-August Universität, Gottingen, Germany (G.H.); Na Homolce Hospital, Prague, Czech Republic (P.N.); St Antonius Ziekenhuis, Nieuwegein, The Netherlands (M.C.P.); University of Auckland, New Zealand (R.D.); CHU de Nantes, France (J.-N.T.); Fourth Military Hospital, Wroclaw, Poland (A.K.); Universität Klinikum Dusseldorf, Germany (R.W.); Cardiovascular Center Aalst, Belgium (M.P.); University Medical Center Schleswig-Holstein, Kiel, Germany (M.R.); Department of Cardiology, St Vincent's Hospital, Sydney, New South Wales, Australia (D.M., C.H.); Department of Cardiology, Prince Charles Hospital, Brisbane, Queensland, Australia (D.W.); Klinikum Großhadern, Munich, Germany (J.H.); Internal Medicine, University of Heidelberg, Germany (P.R.); Golden Jubilee Hospital, Glasgow, Great Britain (M.C.P.); Cardiologicum Hamburg, Germany (M.B.); Bichat Hospital, INSERM, Paris, France (G.J.); Northshore University Health System, Evanston, IL (T.F.); University Medical Centre, Groningen, Netherlands (D.J.v.V.); Wroclaw Medical University, Czech Republic (P.P.); Hospital of the University of Pennsylvania, Philadelphia (F.E.S.); and Columbia University, New York, NY (D.B.).
authors.forename: Robert
authors.initials: R
authors.lastname: Doughty
authors.affiliation: Department of Cardiology, Alfred Hospital, Melbourne, Victoria, Australia (D.M.K., A.W.); Georg-August Universität, Gottingen, Germany (G.H.); Na Homolce Hospital, Prague, Czech Republic (P.N.); St Antonius Ziekenhuis, Nieuwegein, The Netherlands (M.C.P.); University of Auckland, New Zealand (R.D.); CHU de Nantes, France (J.-N.T.); Fourth Military Hospital, Wroclaw, Poland (A.K.); Universität Klinikum Dusseldorf, Germany (R.W.); Cardiovascular Center Aalst, Belgium (M.P.); University Medical Center Schleswig-Holstein, Kiel, Germany (M.R.); Department of Cardiology, St Vincent's Hospital, Sydney, New South Wales, Australia (D.M., C.H.); Department of Cardiology, Prince Charles Hospital, Brisbane, Queensland, Australia (D.W.); Klinikum Großhadern, Munich, Germany (J.H.); Internal Medicine, University of Heidelberg, Germany (P.R.); Golden Jubilee Hospital, Glasgow, Great Britain (M.C.P.); Cardiologicum Hamburg, Germany (M.B.); Bichat Hospital, INSERM, Paris, France (G.J.); Northshore University Health System, Evanston, IL (T.F.); University Medical Centre, Groningen, Netherlands (D.J.v.V.); Wroclaw Medical University, Czech Republic (P.P.); Hospital of the University of Pennsylvania, Philadelphia (F.E.S.); and Columbia University, New York, NY (D.B.).
authors.forename: Jean-Noël
authors.initials: JN
authors.lastname: Trochu
authors.affiliation: Department of Cardiology, Alfred Hospital, Melbourne, Victoria, Australia (D.M.K., A.W.); Georg-August Universität, Gottingen, Germany (G.H.); Na Homolce Hospital, Prague, Czech Republic (P.N.); St Antonius Ziekenhuis, Nieuwegein, The Netherlands (M.C.P.); University of Auckland, New Zealand (R.D.); CHU de Nantes, France (J.-N.T.); Fourth Military Hospital, Wroclaw, Poland (A.K.); Universität Klinikum Dusseldorf, Germany (R.W.); Cardiovascular Center Aalst, Belgium (M.P.); University Medical Center Schleswig-Holstein, Kiel, Germany (M.R.); Department of Cardiology, St Vincent's Hospital, Sydney, New South Wales, Australia (D.M., C.H.); Department of Cardiology, Prince Charles Hospital, Brisbane, Queensland, Australia (D.W.); Klinikum Großhadern, Munich, Germany (J.H.); Internal Medicine, University of Heidelberg, Germany (P.R.); Golden Jubilee Hospital, Glasgow, Great Britain (M.C.P.); Cardiologicum Hamburg, Germany (M.B.); Bichat Hospital, INSERM, Paris, France (G.J.); Northshore University Health System, Evanston, IL (T.F.); University Medical Centre, Groningen, Netherlands (D.J.v.V.); Wroclaw Medical University, Czech Republic (P.P.); Hospital of the University of Pennsylvania, Philadelphia (F.E.S.); and Columbia University, New York, NY (D.B.).
authors.forename: Adam
authors.initials: A
authors.lastname: Kolodziej
authors.affiliation: Department of Cardiology, Alfred Hospital, Melbourne, Victoria, Australia (D.M.K., A.W.); Georg-August Universität, Gottingen, Germany (G.H.); Na Homolce Hospital, Prague, Czech Republic (P.N.); St Antonius Ziekenhuis, Nieuwegein, The Netherlands (M.C.P.); University of Auckland, New Zealand (R.D.); CHU de Nantes, France (J.-N.T.); Fourth Military Hospital, Wroclaw, Poland (A.K.); Universität Klinikum Dusseldorf, Germany (R.W.); Cardiovascular Center Aalst, Belgium (M.P.); University Medical Center Schleswig-Holstein, Kiel, Germany (M.R.); Department of Cardiology, St Vincent's Hospital, Sydney, New South Wales, Australia (D.M., C.H.); Department of Cardiology, Prince Charles Hospital, Brisbane, Queensland, Australia (D.W.); Klinikum Großhadern, Munich, Germany (J.H.); Internal Medicine, University of Heidelberg, Germany (P.R.); Golden Jubilee Hospital, Glasgow, Great Britain (M.C.P.); Cardiologicum Hamburg, Germany (M.B.); Bichat Hospital, INSERM, Paris, France (G.J.); Northshore University Health System, Evanston, IL (T.F.); University Medical Centre, Groningen, Netherlands (D.J.v.V.); Wroclaw Medical University, Czech Republic (P.P.); Hospital of the University of Pennsylvania, Philadelphia (F.E.S.); and Columbia University, New York, NY (D.B.).
authors.forename: Ralf
authors.initials: R
authors.lastname: Westenfeld
authors.affiliation: Department of Cardiology, Alfred Hospital, Melbourne, Victoria, Australia (D.M.K., A.W.); Georg-August Universität, Gottingen, Germany (G.H.); Na Homolce Hospital, Prague, Czech Republic (P.N.); St Antonius Ziekenhuis, Nieuwegein, The Netherlands (M.C.P.); University of Auckland, New Zealand (R.D.); CHU de Nantes, France (J.-N.T.); Fourth Military Hospital, Wroclaw, Poland (A.K.); Universität Klinikum Dusseldorf, Germany (R.W.); Cardiovascular Center Aalst, Belgium (M.P.); University Medical Center Schleswig-Holstein, Kiel, Germany (M.R.); Department of Cardiology, St Vincent's Hospital, Sydney, New South Wales, Australia (D.M., C.H.); Department of Cardiology, Prince Charles Hospital, Brisbane, Queensland, Australia (D.W.); Klinikum Großhadern, Munich, Germany (J.H.); Internal Medicine, University of Heidelberg, Germany (P.R.); Golden Jubilee Hospital, Glasgow, Great Britain (M.C.P.); Cardiologicum Hamburg, Germany (M.B.); Bichat Hospital, INSERM, Paris, France (G.J.); Northshore University Health System, Evanston, IL (T.F.); University Medical Centre, Groningen, Netherlands (D.J.v.V.); Wroclaw Medical University, Czech Republic (P.P.); Hospital of the University of Pennsylvania, Philadelphia (F.E.S.); and Columbia University, New York, NY (D.B.).
authors.forename: Martin
authors.initials: M
authors.lastname: Penicka
authors.affiliation: Department of Cardiology, Alfred Hospital, Melbourne, Victoria, Australia (D.M.K., A.W.); Georg-August Universität, Gottingen, Germany (G.H.); Na Homolce Hospital, Prague, Czech Republic (P.N.); St Antonius Ziekenhuis, Nieuwegein, The Netherlands (M.C.P.); University of Auckland, New Zealand (R.D.); CHU de Nantes, France (J.-N.T.); Fourth Military Hospital, Wroclaw, Poland (A.K.); Universität Klinikum Dusseldorf, Germany (R.W.); Cardiovascular Center Aalst, Belgium (M.P.); University Medical Center Schleswig-Holstein, Kiel, Germany (M.R.); Department of Cardiology, St Vincent's Hospital, Sydney, New South Wales, Australia (D.M., C.H.); Department of Cardiology, Prince Charles Hospital, Brisbane, Queensland, Australia (D.W.); Klinikum Großhadern, Munich, Germany (J.H.); Internal Medicine, University of Heidelberg, Germany (P.R.); Golden Jubilee Hospital, Glasgow, Great Britain (M.C.P.); Cardiologicum Hamburg, Germany (M.B.); Bichat Hospital, INSERM, Paris, France (G.J.); Northshore University Health System, Evanston, IL (T.F.); University Medical Centre, Groningen, Netherlands (D.J.v.V.); Wroclaw Medical University, Czech Republic (P.P.); Hospital of the University of Pennsylvania, Philadelphia (F.E.S.); and Columbia University, New York, NY (D.B.).
authors.forename: Mark
authors.initials: M
authors.lastname: Rosenberg
authors.affiliation: Department of Cardiology, Alfred Hospital, Melbourne, Victoria, Australia (D.M.K., A.W.); Georg-August Universität, Gottingen, Germany (G.H.); Na Homolce Hospital, Prague, Czech Republic (P.N.); St Antonius Ziekenhuis, Nieuwegein, The Netherlands (M.C.P.); University of Auckland, New Zealand (R.D.); CHU de Nantes, France (J.-N.T.); Fourth Military Hospital, Wroclaw, Poland (A.K.); Universität Klinikum Dusseldorf, Germany (R.W.); Cardiovascular Center Aalst, Belgium (M.P.); University Medical Center Schleswig-Holstein, Kiel, Germany (M.R.); Department of Cardiology, St Vincent's Hospital, Sydney, New South Wales, Australia (D.M., C.H.); Department of Cardiology, Prince Charles Hospital, Brisbane, Queensland, Australia (D.W.); Klinikum Großhadern, Munich, Germany (J.H.); Internal Medicine, University of Heidelberg, Germany (P.R.); Golden Jubilee Hospital, Glasgow, Great Britain (M.C.P.); Cardiologicum Hamburg, Germany (M.B.); Bichat Hospital, INSERM, Paris, France (G.J.); Northshore University Health System, Evanston, IL (T.F.); University Medical Centre, Groningen, Netherlands (D.J.v.V.); Wroclaw Medical University, Czech Republic (P.P.); Hospital of the University of Pennsylvania, Philadelphia (F.E.S.); and Columbia University, New York, NY (D.B.).
authors.forename: Antony
authors.initials: A
authors.lastname: Walton
authors.affiliation: Department of Cardiology, Alfred Hospital, Melbourne, Victoria, Australia (D.M.K., A.W.); Georg-August Universität, Gottingen, Germany (G.H.); Na Homolce Hospital, Prague, Czech Republic (P.N.); St Antonius Ziekenhuis, Nieuwegein, The Netherlands (M.C.P.); University of Auckland, New Zealand (R.D.); CHU de Nantes, France (J.-N.T.); Fourth Military Hospital, Wroclaw, Poland (A.K.); Universität Klinikum Dusseldorf, Germany (R.W.); Cardiovascular Center Aalst, Belgium (M.P.); University Medical Center Schleswig-Holstein, Kiel, Germany (M.R.); Department of Cardiology, St Vincent's Hospital, Sydney, New South Wales, Australia (D.M., C.H.); Department of Cardiology, Prince Charles Hospital, Brisbane, Queensland, Australia (D.W.); Klinikum Großhadern, Munich, Germany (J.H.); Internal Medicine, University of Heidelberg, Germany (P.R.); Golden Jubilee Hospital, Glasgow, Great Britain (M.C.P.); Cardiologicum Hamburg, Germany (M.B.); Bichat Hospital, INSERM, Paris, France (G.J.); Northshore University Health System, Evanston, IL (T.F.); University Medical Centre, Groningen, Netherlands (D.J.v.V.); Wroclaw Medical University, Czech Republic (P.P.); Hospital of the University of Pennsylvania, Philadelphia (F.E.S.); and Columbia University, New York, NY (D.B.).
authors.forename: David
authors.initials: D
authors.lastname: Muller
authors.affiliation: Department of Cardiology, Alfred Hospital, Melbourne, Victoria, Australia (D.M.K., A.W.); Georg-August Universität, Gottingen, Germany (G.H.); Na Homolce Hospital, Prague, Czech Republic (P.N.); St Antonius Ziekenhuis, Nieuwegein, The Netherlands (M.C.P.); University of Auckland, New Zealand (R.D.); CHU de Nantes, France (J.-N.T.); Fourth Military Hospital, Wroclaw, Poland (A.K.); Universität Klinikum Dusseldorf, Germany (R.W.); Cardiovascular Center Aalst, Belgium (M.P.); University Medical Center Schleswig-Holstein, Kiel, Germany (M.R.); Department of Cardiology, St Vincent's Hospital, Sydney, New South Wales, Australia (D.M., C.H.); Department of Cardiology, Prince Charles Hospital, Brisbane, Queensland, Australia (D.W.); Klinikum Großhadern, Munich, Germany (J.H.); Internal Medicine, University of Heidelberg, Germany (P.R.); Golden Jubilee Hospital, Glasgow, Great Britain (M.C.P.); Cardiologicum Hamburg, Germany (M.B.); Bichat Hospital, INSERM, Paris, France (G.J.); Northshore University Health System, Evanston, IL (T.F.); University Medical Centre, Groningen, Netherlands (D.J.v.V.); Wroclaw Medical University, Czech Republic (P.P.); Hospital of the University of Pennsylvania, Philadelphia (F.E.S.); and Columbia University, New York, NY (D.B.).
authors.forename: Darren
authors.initials: D
authors.lastname: Walters
authors.affiliation: Department of Cardiology, Alfred Hospital, Melbourne, Victoria, Australia (D.M.K., A.W.); Georg-August Universität, Gottingen, Germany (G.H.); Na Homolce Hospital, Prague, Czech Republic (P.N.); St Antonius Ziekenhuis, Nieuwegein, The Netherlands (M.C.P.); University of Auckland, New Zealand (R.D.); CHU de Nantes, France (J.-N.T.); Fourth Military Hospital, Wroclaw, Poland (A.K.); Universität Klinikum Dusseldorf, Germany (R.W.); Cardiovascular Center Aalst, Belgium (M.P.); University Medical Center Schleswig-Holstein, Kiel, Germany (M.R.); Department of Cardiology, St Vincent's Hospital, Sydney, New South Wales, Australia (D.M., C.H.); Department of Cardiology, Prince Charles Hospital, Brisbane, Queensland, Australia (D.W.); Klinikum Großhadern, Munich, Germany (J.H.); Internal Medicine, University of Heidelberg, Germany (P.R.); Golden Jubilee Hospital, Glasgow, Great Britain (M.C.P.); Cardiologicum Hamburg, Germany (M.B.); Bichat Hospital, INSERM, Paris, France (G.J.); Northshore University Health System, Evanston, IL (T.F.); University Medical Centre, Groningen, Netherlands (D.J.v.V.); Wroclaw Medical University, Czech Republic (P.P.); Hospital of the University of Pennsylvania, Philadelphia (F.E.S.); and Columbia University, New York, NY (D.B.).
authors.forename: Jorg
authors.initials: J
authors.lastname: Hausleiter
authors.affiliation: Department of Cardiology, Alfred Hospital, Melbourne, Victoria, Australia (D.M.K., A.W.); Georg-August Universität, Gottingen, Germany (G.H.); Na Homolce Hospital, Prague, Czech Republic (P.N.); St Antonius Ziekenhuis, Nieuwegein, The Netherlands (M.C.P.); University of Auckland, New Zealand (R.D.); CHU de Nantes, France (J.-N.T.); Fourth Military Hospital, Wroclaw, Poland (A.K.); Universität Klinikum Dusseldorf, Germany (R.W.); Cardiovascular Center Aalst, Belgium (M.P.); University Medical Center Schleswig-Holstein, Kiel, Germany (M.R.); Department of Cardiology, St Vincent's Hospital, Sydney, New South Wales, Australia (D.M., C.H.); Department of Cardiology, Prince Charles Hospital, Brisbane, Queensland, Australia (D.W.); Klinikum Großhadern, Munich, Germany (J.H.); Internal Medicine, University of Heidelberg, Germany (P.R.); Golden Jubilee Hospital, Glasgow, Great Britain (M.C.P.); Cardiologicum Hamburg, Germany (M.B.); Bichat Hospital, INSERM, Paris, France (G.J.); Northshore University Health System, Evanston, IL (T.F.); University Medical Centre, Groningen, Netherlands (D.J.v.V.); Wroclaw Medical University, Czech Republic (P.P.); Hospital of the University of Pennsylvania, Philadelphia (F.E.S.); and Columbia University, New York, NY (D.B.).
authors.forename: Philip
authors.initials: P
authors.lastname: Raake
authors.affiliation: Department of Cardiology, Alfred Hospital, Melbourne, Victoria, Australia (D.M.K., A.W.); Georg-August Universität, Gottingen, Germany (G.H.); Na Homolce Hospital, Prague, Czech Republic (P.N.); St Antonius Ziekenhuis, Nieuwegein, The Netherlands (M.C.P.); University of Auckland, New Zealand (R.D.); CHU de Nantes, France (J.-N.T.); Fourth Military Hospital, Wroclaw, Poland (A.K.); Universität Klinikum Dusseldorf, Germany (R.W.); Cardiovascular Center Aalst, Belgium (M.P.); University Medical Center Schleswig-Holstein, Kiel, Germany (M.R.); Department of Cardiology, St Vincent's Hospital, Sydney, New South Wales, Australia (D.M., C.H.); Department of Cardiology, Prince Charles Hospital, Brisbane, Queensland, Australia (D.W.); Klinikum Großhadern, Munich, Germany (J.H.); Internal Medicine, University of Heidelberg, Germany (P.R.); Golden Jubilee Hospital, Glasgow, Great Britain (M.C.P.); Cardiologicum Hamburg, Germany (M.B.); Bichat Hospital, INSERM, Paris, France (G.J.); Northshore University Health System, Evanston, IL (T.F.); University Medical Centre, Groningen, Netherlands (D.J.v.V.); Wroclaw Medical University, Czech Republic (P.P.); Hospital of the University of Pennsylvania, Philadelphia (F.E.S.); and Columbia University, New York, NY (D.B.).
authors.forename: Mark C
authors.initials: MC
authors.lastname: Petrie
authors.affiliation: Department of Cardiology, Alfred Hospital, Melbourne, Victoria, Australia (D.M.K., A.W.); Georg-August Universität, Gottingen, Germany (G.H.); Na Homolce Hospital, Prague, Czech Republic (P.N.); St Antonius Ziekenhuis, Nieuwegein, The Netherlands (M.C.P.); University of Auckland, New Zealand (R.D.); CHU de Nantes, France (J.-N.T.); Fourth Military Hospital, Wroclaw, Poland (A.K.); Universität Klinikum Dusseldorf, Germany (R.W.); Cardiovascular Center Aalst, Belgium (M.P.); University Medical Center Schleswig-Holstein, Kiel, Germany (M.R.); Department of Cardiology, St Vincent's Hospital, Sydney, New South Wales, Australia (D.M., C.H.); Department of Cardiology, Prince Charles Hospital, Brisbane, Queensland, Australia (D.W.); Klinikum Großhadern, Munich, Germany (J.H.); Internal Medicine, University of Heidelberg, Germany (P.R.); Golden Jubilee Hospital, Glasgow, Great Britain (M.C.P.); Cardiologicum Hamburg, Germany (M.B.); Bichat Hospital, INSERM, Paris, France (G.J.); Northshore University Health System, Evanston, IL (T.F.); University Medical Centre, Groningen, Netherlands (D.J.v.V.); Wroclaw Medical University, Czech Republic (P.P.); Hospital of the University of Pennsylvania, Philadelphia (F.E.S.); and Columbia University, New York, NY (D.B.).
authors.forename: Martin
authors.initials: M
authors.lastname: Bergmann
authors.affiliation: Department of Cardiology, Alfred Hospital, Melbourne, Victoria, Australia (D.M.K., A.W.); Georg-August Universität, Gottingen, Germany (G.H.); Na Homolce Hospital, Prague, Czech Republic (P.N.); St Antonius Ziekenhuis, Nieuwegein, The Netherlands (M.C.P.); University of Auckland, New Zealand (R.D.); CHU de Nantes, France (J.-N.T.); Fourth Military Hospital, Wroclaw, Poland (A.K.); Universität Klinikum Dusseldorf, Germany (R.W.); Cardiovascular Center Aalst, Belgium (M.P.); University Medical Center Schleswig-Holstein, Kiel, Germany (M.R.); Department of Cardiology, St Vincent's Hospital, Sydney, New South Wales, Australia (D.M., C.H.); Department of Cardiology, Prince Charles Hospital, Brisbane, Queensland, Australia (D.W.); Klinikum Großhadern, Munich, Germany (J.H.); Internal Medicine, University of Heidelberg, Germany (P.R.); Golden Jubilee Hospital, Glasgow, Great Britain (M.C.P.); Cardiologicum Hamburg, Germany (M.B.); Bichat Hospital, INSERM, Paris, France (G.J.); Northshore University Health System, Evanston, IL (T.F.); University Medical Centre, Groningen, Netherlands (D.J.v.V.); Wroclaw Medical University, Czech Republic (P.P.); Hospital of the University of Pennsylvania, Philadelphia (F.E.S.); and Columbia University, New York, NY (D.B.).
authors.forename: Guillaume
authors.initials: G
authors.lastname: Jondeau
authors.affiliation: Department of Cardiology, Alfred Hospital, Melbourne, Victoria, Australia (D.M.K., A.W.); Georg-August Universität, Gottingen, Germany (G.H.); Na Homolce Hospital, Prague, Czech Republic (P.N.); St Antonius Ziekenhuis, Nieuwegein, The Netherlands (M.C.P.); University of Auckland, New Zealand (R.D.); CHU de Nantes, France (J.-N.T.); Fourth Military Hospital, Wroclaw, Poland (A.K.); Universität Klinikum Dusseldorf, Germany (R.W.); Cardiovascular Center Aalst, Belgium (M.P.); University Medical Center Schleswig-Holstein, Kiel, Germany (M.R.); Department of Cardiology, St Vincent's Hospital, Sydney, New South Wales, Australia (D.M., C.H.); Department of Cardiology, Prince Charles Hospital, Brisbane, Queensland, Australia (D.W.); Klinikum Großhadern, Munich, Germany (J.H.); Internal Medicine, University of Heidelberg, Germany (P.R.); Golden Jubilee Hospital, Glasgow, Great Britain (M.C.P.); Cardiologicum Hamburg, Germany (M.B.); Bichat Hospital, INSERM, Paris, France (G.J.); Northshore University Health System, Evanston, IL (T.F.); University Medical Centre, Groningen, Netherlands (D.J.v.V.); Wroclaw Medical University, Czech Republic (P.P.); Hospital of the University of Pennsylvania, Philadelphia (F.E.S.); and Columbia University, New York, NY (D.B.).
authors.forename: Ted
authors.initials: T
authors.lastname: Feldman
authors.affiliation: Department of Cardiology, Alfred Hospital, Melbourne, Victoria, Australia (D.M.K., A.W.); Georg-August Universität, Gottingen, Germany (G.H.); Na Homolce Hospital, Prague, Czech Republic (P.N.); St Antonius Ziekenhuis, Nieuwegein, The Netherlands (M.C.P.); University of Auckland, New Zealand (R.D.); CHU de Nantes, France (J.-N.T.); Fourth Military Hospital, Wroclaw, Poland (A.K.); Universität Klinikum Dusseldorf, Germany (R.W.); Cardiovascular Center Aalst, Belgium (M.P.); University Medical Center Schleswig-Holstein, Kiel, Germany (M.R.); Department of Cardiology, St Vincent's Hospital, Sydney, New South Wales, Australia (D.M., C.H.); Department of Cardiology, Prince Charles Hospital, Brisbane, Queensland, Australia (D.W.); Klinikum Großhadern, Munich, Germany (J.H.); Internal Medicine, University of Heidelberg, Germany (P.R.); Golden Jubilee Hospital, Glasgow, Great Britain (M.C.P.); Cardiologicum Hamburg, Germany (M.B.); Bichat Hospital, INSERM, Paris, France (G.J.); Northshore University Health System, Evanston, IL (T.F.); University Medical Centre, Groningen, Netherlands (D.J.v.V.); Wroclaw Medical University, Czech Republic (P.P.); Hospital of the University of Pennsylvania, Philadelphia (F.E.S.); and Columbia University, New York, NY (D.B.).
authors.forename: Dirk J van
authors.initials: DJ
authors.lastname: Veldhuisen
authors.affiliation: Department of Cardiology, Alfred Hospital, Melbourne, Victoria, Australia (D.M.K., A.W.); Georg-August Universität, Gottingen, Germany (G.H.); Na Homolce Hospital, Prague, Czech Republic (P.N.); St Antonius Ziekenhuis, Nieuwegein, The Netherlands (M.C.P.); University of Auckland, New Zealand (R.D.); CHU de Nantes, France (J.-N.T.); Fourth Military Hospital, Wroclaw, Poland (A.K.); Universität Klinikum Dusseldorf, Germany (R.W.); Cardiovascular Center Aalst, Belgium (M.P.); University Medical Center Schleswig-Holstein, Kiel, Germany (M.R.); Department of Cardiology, St Vincent's Hospital, Sydney, New South Wales, Australia (D.M., C.H.); Department of Cardiology, Prince Charles Hospital, Brisbane, Queensland, Australia (D.W.); Klinikum Großhadern, Munich, Germany (J.H.); Internal Medicine, University of Heidelberg, Germany (P.R.); Golden Jubilee Hospital, Glasgow, Great Britain (M.C.P.); Cardiologicum Hamburg, Germany (M.B.); Bichat Hospital, INSERM, Paris, France (G.J.); Northshore University Health System, Evanston, IL (T.F.); University Medical Centre, Groningen, Netherlands (D.J.v.V.); Wroclaw Medical University, Czech Republic (P.P.); Hospital of the University of Pennsylvania, Philadelphia (F.E.S.); and Columbia University, New York, NY (D.B.).
authors.forename: Piotr
authors.initials: P
authors.lastname: Ponikowski
authors.affiliation: Department of Cardiology, Alfred Hospital, Melbourne, Victoria, Australia (D.M.K., A.W.); Georg-August Universität, Gottingen, Germany (G.H.); Na Homolce Hospital, Prague, Czech Republic (P.N.); St Antonius Ziekenhuis, Nieuwegein, The Netherlands (M.C.P.); University of Auckland, New Zealand (R.D.); CHU de Nantes, France (J.-N.T.); Fourth Military Hospital, Wroclaw, Poland (A.K.); Universität Klinikum Dusseldorf, Germany (R.W.); Cardiovascular Center Aalst, Belgium (M.P.); University Medical Center Schleswig-Holstein, Kiel, Germany (M.R.); Department of Cardiology, St Vincent's Hospital, Sydney, New South Wales, Australia (D.M., C.H.); Department of Cardiology, Prince Charles Hospital, Brisbane, Queensland, Australia (D.W.); Klinikum Großhadern, Munich, Germany (J.H.); Internal Medicine, University of Heidelberg, Germany (P.R.); Golden Jubilee Hospital, Glasgow, Great Britain (M.C.P.); Cardiologicum Hamburg, Germany (M.B.); Bichat Hospital, INSERM, Paris, France (G.J.); Northshore University Health System, Evanston, IL (T.F.); University Medical Centre, Groningen, Netherlands (D.J.v.V.); Wroclaw Medical University, Czech Republic (P.P.); Hospital of the University of Pennsylvania, Philadelphia (F.E.S.); and Columbia University, New York, NY (D.B.).
authors.forename: Frank E
authors.initials: FE
authors.lastname: Silvestry
authors.affiliation: Department of Cardiology, Alfred Hospital, Melbourne, Victoria, Australia (D.M.K., A.W.); Georg-August Universität, Gottingen, Germany (G.H.); Na Homolce Hospital, Prague, Czech Republic (P.N.); St Antonius Ziekenhuis, Nieuwegein, The Netherlands (M.C.P.); University of Auckland, New Zealand (R.D.); CHU de Nantes, France (J.-N.T.); Fourth Military Hospital, Wroclaw, Poland (A.K.); Universität Klinikum Dusseldorf, Germany (R.W.); Cardiovascular Center Aalst, Belgium (M.P.); University Medical Center Schleswig-Holstein, Kiel, Germany (M.R.); Department of Cardiology, St Vincent's Hospital, Sydney, New South Wales, Australia (D.M., C.H.); Department of Cardiology, Prince Charles Hospital, Brisbane, Queensland, Australia (D.W.); Klinikum Großhadern, Munich, Germany (J.H.); Internal Medicine, University of Heidelberg, Germany (P.R.); Golden Jubilee Hospital, Glasgow, Great Britain (M.C.P.); Cardiologicum Hamburg, Germany (M.B.); Bichat Hospital, INSERM, Paris, France (G.J.); Northshore University Health System, Evanston, IL (T.F.); University Medical Centre, Groningen, Netherlands (D.J.v.V.); Wroclaw Medical University, Czech Republic (P.P.); Hospital of the University of Pennsylvania, Philadelphia (F.E.S.); and Columbia University, New York, NY (D.B.).
authors.forename: Dan
authors.initials: D
authors.lastname: Burkhoff
authors.affiliation: Department of Cardiology, Alfred Hospital, Melbourne, Victoria, Australia (D.M.K., A.W.); Georg-August Universität, Gottingen, Germany (G.H.); Na Homolce Hospital, Prague, Czech Republic (P.N.); St Antonius Ziekenhuis, Nieuwegein, The Netherlands (M.C.P.); University of Auckland, New Zealand (R.D.); CHU de Nantes, France (J.-N.T.); Fourth Military Hospital, Wroclaw, Poland (A.K.); Universität Klinikum Dusseldorf, Germany (R.W.); Cardiovascular Center Aalst, Belgium (M.P.); University Medical Center Schleswig-Holstein, Kiel, Germany (M.R.); Department of Cardiology, St Vincent's Hospital, Sydney, New South Wales, Australia (D.M., C.H.); Department of Cardiology, Prince Charles Hospital, Brisbane, Queensland, Australia (D.W.); Klinikum Großhadern, Munich, Germany (J.H.); Internal Medicine, University of Heidelberg, Germany (P.R.); Golden Jubilee Hospital, Glasgow, Great Britain (M.C.P.); Cardiologicum Hamburg, Germany (M.B.); Bichat Hospital, INSERM, Paris, France (G.J.); Northshore University Health System, Evanston, IL (T.F.); University Medical Centre, Groningen, Netherlands (D.J.v.V.); Wroclaw Medical University, Czech Republic (P.P.); Hospital of the University of Pennsylvania, Philadelphia (F.E.S.); and Columbia University, New York, NY (D.B.).
authors.forename: Christopher
authors.initials: C
authors.lastname: Hayward
mesh_terms: D000328:Adult; D000368:Aged; D062185:Atrial Pressure / Q000502:physiology; D006328:Cardiac Catheterization; D004867:Equipment Design; D005260:Female; D005500:Follow-Up Studies; D006325:Heart Atria; D006333:Heart Failure / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D019919:Prosthesis Implantation; D011788:Quality of Life; D013997:Time Factors; D016896:Treatment Outcome; D016277:Ventricular Function, Left
keywords: heart failure; hemodynamics; physiology; therapeutics