title: Effectiveness of Changing the Application of Japanese Honey to a Hydrocolloid Dressing in Between the Inflammatory and Proliferative Phases on Cutaneous Wound Healing in Male Mice.
abstract: BACKGROUND
  The aim of this study was to investigate the effects of changing the application of Japanese honey to a hydrocolloid dressing (HCD) in between the inflammatory and proliferative phases on cutaneous wound healing in 8-week-old, BALB/cCrSlc male mice.
  
  
  METHODS
  Mice were divided into 4 groups: acacia honey followed by a HCD, buckwheat flour honey followed by a HCD, Chinese milk vetch honey followed by a HCD, and a HCD alone (control group). All mice received 2 full-thickness wounds on both sides of the dorsum using a Disposable Biopsy Punch. The wounds of the control group were covered with a HCD, whereas wounds in the other groups were treated with 0.1 mL of the relevant type of honey until day 3 post-wound and then were covered with a HCD from days 4 to 14.
  
  
  RESULTS
  In the experimental groups, the wound area ratio was significantly smaller in the inflammatory phase but significantly larger in the proliferative phase. Reepithelialization, collagen deposition, and wound contraction were significantly delayed compared with those in the control group.
  
  
  CONCLUSIONS
  The re-expansion of the wounds in the proliferative phase could not be prevented, and reepithelialization, collagen deposition, and wound contraction were delayed compared with those upon the use of a HCD.
  
  
  CONCLUSIONS
  The study's authors concluded that these methods do not promote cutaneous wound healing better than the use of a HCD alone.
authors.forename: Kanae
authors.initials: K
authors.lastname: Mukai
authors.forename: Emi
authors.initials: E
authors.lastname: Komatsu
authors.forename: Misa
authors.initials: M
authors.lastname: Yamanishi
authors.forename: Misako
authors.initials: M
authors.lastname: Hutakuchi
authors.forename: Kayo
authors.initials: K
authors.lastname: Kanzaka
authors.forename: Yuka
authors.initials: Y
authors.lastname: Uno
authors.forename: Shizuka
authors.initials: S
authors.lastname: Yamazaki
authors.forename: Shizuka
authors.initials: S
authors.lastname: Kato
authors.forename: Tomomi
authors.initials: T
authors.lastname: Yamamoto
authors.forename: Mayumi
authors.initials: M
authors.lastname: Hattori
authors.forename: Yukari
authors.initials: Y
authors.lastname: Nakajima
authors.forename: Tamae
authors.initials: T
authors.lastname: Urai
authors.forename: Kimi
authors.initials: K
authors.lastname: Asano
authors.forename: Naoko
authors.initials: N
authors.lastname: Murakado
authors.forename: Mayumi
authors.initials: M
authors.lastname: Okuwa
authors.forename: Toshio
authors.initials: T
authors.lastname: Nakatani
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D047070:Bandages, Hydrocolloid; D003102:Colloids / Q000494:pharmacology*; D004195:Disease Models, Animal; D006722:Honey; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D014945:Wound Healing / Q000502:physiology*; D014947:Wounds and Injuries / Q000473:pathology*
chemical_list: D003102:Colloids