title: Osteopontin as a Potential Therapeutic Target for Ischemic Stroke.
abstract: BACKGROUND
  Ischemic stroke is the third leading cause of death and the most frequent cause of permanent disability in adults worldwide. Tremendous advances have been made in understanding of the pathophysiology of cerebral ischemia. Nevertheless, there is still no effective neuroprotectant available in the clinical work. Recently, osteopontin (OPN), a glycophosphoprotein, has attracted more attention due to its various effects in cardiovascular and nervous system diseases.
  
  
  OBJECTIVE
  The aim of present review was to summarize recent findings about neuroprotective effects of OPN on ischemic stroke, targeting to provide a novel therapeutic strategy.
  
  
  METHODS
  To prepare this review, a pathophysiological and pharmacological literature survey was performed using PubMed, and Web of Science. Also, some statistical and epidemiological literature sources were used.
  
  
  RESULTS
  Mounting evidence indicates that OPN attenuates cerebral damage and promotes neurogenesis in ischemic stroke by binding to its receptors to activate diverse signaling pathways.
  
  
  CONCLUSIONS
  The paper highlights the neuroprotective and pro-regenerative effects of OPN after cerebral ischemia, which would demonstrate its therapeutic potential in ischemic stroke and other informs of ischemic brain injury.
authors.affiliation: Department of Neurosurgery, The Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, China.
authors.forename: Qiquan
authors.initials: Q
authors.lastname: Zhu
authors.affiliation: Department of Neurosurgery, The Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Luo
authors.affiliation: Department of Neurosurgery, The Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Neurosurgery, The Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Neurosurgery, The Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, China.
authors.forename: Hansheng
authors.initials: H
authors.lastname: Luo
authors.affiliation: Department of Neurosurgery, The Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Huang
authors.affiliation: Department of Neurosurgery, The Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Cheng
authors.affiliation: Department of Neurosurgery, The Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, China.
authors.forename: Zongyi
authors.initials: Z
authors.lastname: Xie
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism; D002545:Brain Ischemia / Q000378:metabolism*; D006801:Humans; D018696:Neuroprotective Agents / Q000378:metabolism; D053495:Osteopontin / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology; D020521:Stroke / Q000378:metabolism*
chemical_list: D018696:Neuroprotective Agents; D053495:Osteopontin
keywords: Apoptosis; blood-brain barrier breakdown; neuroinflammation; neuroprotection; osteopontin; stroke