title: New nanostructured support for carrier-mediated electromembrane extraction of high polar compounds.
abstract: A new support has been proposed to be used for carrier-mediated electromembrane extraction purposes. The new support (Tiss®-OH) is a 100µm thickness sheet nanofiber membrane manufactured by electrospinning and composed by acrylic nanofibers. It has been used in an electromembrane extraction (EME) combined with a HPLC procedure using diode array detection. The proposed method has been used for the extraction of four high polarity acidic compounds: nicotinic acid, amoxicillin, hippuric acid and salicylic acid. Analytes were extracted from an aqueous sample solution (pH 4) (donor phase) using a Tiss®-OH sheet that supports a 5% (w/v) Aliquat®336 in 1-octanol liquid membrane. Aqueous solution (pH 6) was used as acceptor phase. The electrical field was generated from a d.c. electrical current of 100V through two spiral shaped platinum wires placed into donor and acceptor phases. Analytes were extracted in 10min with recoveries in the 60-85% range. The proposed EME procedure has been successfully applied to the determination of the target analytes in human urine samples.
authors.affiliation: Department of Analytical Chemistry, Faculty of Chemistry, Universidad de Sevilla, c/Prof. García González, s/n, 41012 Seville, Spain.
authors.forename: Cristina
authors.initials: C
authors.lastname: Román-Hidalgo
authors.affiliation: Department of Analytical Chemistry, Faculty of Chemistry, Universidad de Sevilla, c/Prof. García González, s/n, 41012 Seville, Spain.
authors.forename: María Jesús
authors.initials: MJ
authors.lastname: Martín-Valero
authors.affiliation: Department of Analytical Chemistry, Faculty of Chemistry, Universidad de Sevilla, c/Prof. García González, s/n, 41012 Seville, Spain; Research Centre of Health and Environment (CYSMA), University of Huelva, Spain.
authors.forename: Rut
authors.initials: R
authors.lastname: Fernández-Torres
authors.affiliation: Department of Analytical Chemistry, Faculty of Chemistry, Universidad de Sevilla, c/Prof. García González, s/n, 41012 Seville, Spain.
authors.forename: Manuel
authors.initials: M
authors.lastname: Callejón-Mochón
authors.affiliation: Department of Analytical Chemistry, Faculty of Chemistry, Universidad de Sevilla, c/Prof. García González, s/n, 41012 Seville, Spain. Electronic address: mabello@us.es.
authors.forename: Miguel Ángel
authors.initials: MÁ
authors.lastname: Bello-López
mesh_terms: D000658:Amoxicillin / Q000032:analysis / Q000302:isolation & purification / Q000652:urine; D002851:Chromatography, High Pressure Liquid; D055664:Electrochemical Techniques / Q000379:methods*; D006626:Hippurates / Q000032:analysis / Q000302:isolation & purification; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008567:Membranes, Artificial; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure; D009525:Niacin / Q000032:analysis / Q000302:isolation & purification; D009930:Organic Chemicals / Q000032:analysis* / Q000302:isolation & purification; D015203:Reproducibility of Results; D020156:Salicylic Acid / Q000032:analysis / Q000302:isolation & purification
chemical_list: D006626:Hippurates; D008567:Membranes, Artificial; D009930:Organic Chemicals; D009525:Niacin; D000658:Amoxicillin; D020156:Salicylic Acid; C030514:hippuric acid
keywords: Electromembrane extraction; Nanostructured polymeric support; Polar compounds