title: Efficacy and duration of action of oral fluralaner and spot-on moxidectin/imidacloprid in cats infested with Lynxacarus radovskyi.
abstract: BACKGROUND
  Lynxacarus radovskyi has been observed in cats in Malaysia; previously treatment with fipronil and moxidectin/imidacloprid spot-on has been described.
  
  
  OBJECTIVE
  To compare the efficacy of two spot-on treatments of moxidectin/imidacloprid, two weeks apart to a single oral dose of fluralaner against Lynxacarus radovskyi and evaluate time to re-infestation.
  
  
  METHODS
  Thirty cats were assigned to three groups of ten cats each. Group 1 received one 250 mg fluralaner tablet. Group 2 received two doses of moxidectin/imidacloprid spot-on two weeks apart. Group 3 consisted of untreated controls. For each cat, three plucks of about 50 hairs each were collected from three sites (dorsal neck, lateral thigh and perineal/tail region) for a total of nine pluckings every two weeks. Severity of infestation was scored from 0 (no parasite), to 1 (only nonhatched eggs), 2 (both hatched and nonhatched eggs), 3 (<50 mites) and 4 (>50 mites). Efficacy was compared between treatment groups and over time in the same group, and results analysed statistically. Re-infestation was defined as the identification of new eggs or mites on hair pluckings.
  
  
  RESULTS
  Moxidectin/imidacloprid spot-on and oral fluralaner achieved 100% eradication within 28 days. No significant difference was observed between groups 1 and 2; re-infestation occurred by Day 56 in both treatment groups.
  
  
  CONCLUSIONS
  A single dose of oral fluralaner or two moxidectin/imidacloprid spot-on treatments two weeks apart are efficacious in the eradication of L. radovskyi in cats and able to prevent re-infestation for at least 42 days post-treatment.
authors.affiliation: Han Veterinary Surgery, 50 JLN Molek 2/2, TMN Molek, 81100, Johor Bahru, Johor, Malaysia.
authors.forename: Hock Siew
authors.initials: HS
authors.lastname: Han
authors.affiliation: Servizi Dermatologici Veterinari, Strada Bedale della Ressia 2, 12016, Peveragno (CN), Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Noli
authors.affiliation: Department of Translational Medicine, Unit of Medical Statistics and Cancer Epidemiology, University "Amedeo Avogadro" of Piemonte Orientale, Via Solaroli 17, Novara, Italy.
authors.forename: Tiziana
authors.initials: T
authors.lastname: Cena
mesh_terms: D056810:Acaricides / Q000008:administration & dosage / Q000627:therapeutic use; D000284:Administration, Oral; D000287:Administration, Topical; D000818:Animals; D002371:Cat Diseases / Q000188:drug therapy / Q000469:parasitology*; D002415:Cats; D004338:Drug Combinations; D005260:Female; D006197:Hair / Q000469:parasitology; D007093:Imidazoles / Q000008:administration & dosage / Q000627:therapeutic use*; D007555:Isoxazoles / Q000008:administration & dosage / Q000627:therapeutic use*; D018942:Macrolides / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008924:Mite Infestations / Q000188:drug therapy / Q000662:veterinary*; D000073943:Neonicotinoids; D009574:Nitro Compounds / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: C000591860:A1443 compound; D056810:Acaricides; D004338:Drug Combinations; D007093:Imidazoles; D007555:Isoxazoles; D018942:Macrolides; D000073943:Neonicotinoids; D009574:Nitro Compounds; C082359:imidacloprid; C027837:moxidectin