title: FGFR4Arg388 Is Correlated with Poor Survival in Resected Colon Cancer Promoting Epithelial to Mesenchymal Transition.
abstract: OBJECTIVE
  Fibroblast growth factor receptor 4 (FGFR4) plays an important role in cancer progression during tumor proliferation, invasion, and metastasis. This study evaluated the prognostic role ofFGFR4polymorphism in patients with resected colon cancer, including the underlying mechanism.
  
  
  METHODS
  FGFR4polymorphism was characterized in patientswho received curative resection for stage III colon cancer.FGFR4-dependent signal pathways involving cell proliferation, invasion, and migration according to genotypes were also evaluated in transfected colon cancer cell lines.
  
  
  RESULTS
  Among a total of 273 patients, the GG ofFGFR4showed significantly better overall survival than the AG or AA, regardless of adjuvant treatment. In the group of AG or AA, combination of folinic acid, fluorouracil, and oxaliplatin (FOLFOX) resulted in better survival than fluorouracil/leucovorin or no adjuvant chemotherapy. However, in GG, there was no difference among treatment regimens. Using multivariate analyses, the Arg388 carriers, together with age, N stage, poor differentiation, absence of a lymphocyte response, and no adjuvant chemotherapy, had a significantly worse OS than patients with the Gly388 allele. In transfected colon cancer cells, overexpression of Arg388 significantly increased cell proliferation and changes in epithelial to mesenchymal transition markers compared with cells overexpressing the Gly388 allele.
  
  
  CONCLUSIONS
  The Arg388 allele ofFGFR4may be a biomarker and a candidate target for adjuvant treatment of patients with resected colon cancer.
authors.affiliation: Department of Hemato-Oncology, Chonnam National University Hwasun Hospital, Hwasun, Korea.
authors.forename: Sang Hee
authors.initials: SH
authors.lastname: Cho
authors.affiliation: Department of Hemato-Oncology, Chonnam National University Hwasun Hospital, Hwasun, Korea.
authors.forename: Chang Soo
authors.initials: CS
authors.lastname: Hong
authors.affiliation: Department of Preventive Medicine, Chonnam National Medical School, Gwangju, Korea.
authors.forename: Hee Nam
authors.initials: HN
authors.lastname: Kim
authors.affiliation: Department of Preventive Medicine, Chonnam National Medical School, Gwangju, Korea.
authors.forename: Min Ho
authors.initials: MH
authors.lastname: Shin
authors.affiliation: Department of Hemato-Oncology, Chonnam National University Hwasun Hospital, Hwasun, Korea.
authors.forename: Ka Rham
authors.initials: KR
authors.lastname: Kim
authors.affiliation: Department of Hemato-Oncology, Chonnam National University Hwasun Hospital, Hwasun, Korea.
authors.forename: Hyun Jeong
authors.initials: HJ
authors.lastname: Shim
authors.affiliation: Department of Hemato-Oncology, Chonnam National University Hwasun Hospital, Hwasun, Korea.
authors.forename: Jun Eul
authors.initials: JE
authors.lastname: Hwang
authors.affiliation: Department of Hemato-Oncology, Chonnam National University Hwasun Hospital, Hwasun, Korea.
authors.forename: Woo Kyun
authors.initials: WK
authors.lastname: Bae
authors.affiliation: Department of Hemato-Oncology, Chonnam National University Hwasun Hospital, Hwasun, Korea.
authors.forename: Ik Joo
authors.initials: IJ
authors.lastname: Chung
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D019943:Amino Acid Substitution; D045744:Cell Line, Tumor; D002465:Cell Movement; D049109:Cell Proliferation; D017024:Chemotherapy, Adjuvant; D003110:Colonic Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000401:mortality* / Q000473:pathology; D058750:Epithelial-Mesenchymal Transition / Q000235:genetics*; D005260:Female; D015870:Gene Expression; D005838:Genotype; D006801:Humans; D008297:Male; D053842:Microsatellite Instability; D008875:Middle Aged; D009154:Mutation; D009367:Neoplasm Staging; D011110:Polymorphism, Genetic; D011379:Prognosis; D051499:Receptor, Fibroblast Growth Factor, Type 4 / Q000235:genetics* / Q000378:metabolism; D015398:Signal Transduction
chemical_list: C496371:FGFR4 protein, human; D051499:Receptor, Fibroblast Growth Factor, Type 4
keywords: Adjuvant chemotherapy; Biomarkers; Colonic neoplasms; FGFR4; Polymorphism; Prognosis