title: Cone Beam X-Ray Luminescence Tomography Imaging Based on KA-FEM Method for Small Animals.
abstract: Cone beam X-ray luminescence tomography can realize fast X-ray luminescence tomography imaging with relatively low scanning time compared with narrow beam X-ray luminescence tomography. However, cone beam X-ray luminescence tomography suffers from an ill-posed reconstruction problem. First, the feasibility of experiments with different penetration and multispectra in small animal has been tested using nanophosphor material. Then, the hybrid reconstruction algorithm with KA-FEM method has been applied in cone beam X-ray luminescence tomography for small animals to overcome the ill-posed reconstruction problem, whose advantage and property have been demonstrated in fluorescence tomography imaging. Thein vivomouse experiment proved the feasibility of the proposed method.
authors.affiliation: College of Life Information Science and Instrument Engineering, Hangzhou Dianzi University, Hangzhou 310018, China.
authors.forename: Dongmei
authors.initials: D
authors.lastname: Chen
authors.affiliation: School of Life Sciences and Technology, Xidian University, Xi'an 710071, China.
authors.forename: Fanzhen
authors.initials: F
authors.lastname: Meng
authors.affiliation: School of Information Sciences and Technology, Northwest University, Xi'an, Shaanxi 710069, China.
authors.forename: Fengjun
authors.initials: F
authors.lastname: Zhao
authors.affiliation: School of Life Sciences and Technology, Xidian University, Xi'an 710071, China.
authors.forename: Cao
authors.identifier: 0000-0002-8749-1716
authors.initials: C
authors.lastname: Xu
mesh_terms: D000465:Algorithms; D000818:Animals; D054893:Cone-Beam Computed Tomography / Q000295:instrumentation / Q000379:methods*; D005240:Feasibility Studies; D020342:Finite Element Analysis; D007091:Image Processing, Computer-Assisted / Q000379:methods; D051379:Mice; D015233:Models, Statistical; D036103:Nanotechnology / Q000379:methods; D055620:Optical Phenomena; D019047:Phantoms, Imaging; D010758:Phosphorus / Q000737:chemistry; D013552:Swine; D014018:Tissue Distribution; D014965:X-Rays
chemical_list: D010758:Phosphorus