title: The Effect of Dutasteride on Magnetic Resonance Imaging Defined Prostate Cancer: MAPPED-A Randomized, Placebo Controlled, Double-Blind Clinical Trial.
abstract: Dutasteride, which is licensed for symptomatic benign prostatic hyperplasia, has been associated with a lower progression rate of low risk prostate cancer. We evaluated the effect of dutasteride on prostate cancer volume as assessed by T2-weighted magnetic resonance imaging.
  
  
  
  In this randomized, double-blind, placebo controlled trial, men with biopsy proven, low-intermediate risk prostate cancer (up to Gleason 3 + 4 and PSA up to 15 ng/ml) who had visible lesion of 0.2 ml or greater on T2-weighted magnetic resonance imaging sequences were randomized to daily dutasteride 0.5 mg or placebo for 6 months. Lesion volume was assessed at baseline, and 3 and 6 months with image guided biopsy to the lesion at study exit. The primary end point was the percent reduction in lesion volume over 6 months. This trial was registered with the European Clinical Trials register (EudraCT 2009-102405-18).
  
  
  
  A total of 42 men were recruited between June 2010 and January 2012. In the dutasteride group, the average volumes at baseline and 6 months were 0.55 and 0.38 ml, respectively and the average reduction was 36%. In the placebo group, the average volumes at baseline and 6 months were 0.65 and 0.76 ml, respectively, and the average reduction was -12%. The difference in percent reductions between the groups was 48% (95% CI 27.4-68.3, p <0.0001). The most common adverse event was deterioration in erectile function, which was 25% in men randomized to dutasteride and 16% in men randomized to placebo.
  
  
  
  Dutasteride was associated with a significant reduction in prostate cancer volume on T2-weighted magnetic resonance imaging compared to placebo.
authors.affiliation: Division of Surgery and Interventional Science (CMM, NLR, AD, AJR, HUA, MA, ME), University College London, United Kingdom; Biostatistics Group, University College London Hospitals/University College London Research Support Centre (FJ, GA), University College London, United Kingdom; Department of Urology, University College London Hospitals National Health Service Foundation Trust (CMM, NLR, AD, AJR, HUA, MA, NM, ME), United Kingdom; Department of Radiology (FG, CA), University College London Hospital Trust, United Kingdom; Department of Pathology (AF, CJ), University College London Hospital Trust, United Kingdom; Department of Urology, Charing Cross Hospital, Imperial College National Health Service Trust (MW), United Kingdom; Department of Clinical Oncology, University College Hospital London (AVM), United Kingdom; Klarismo (BJW), United Kingdom; Department of Mathematics, Imperial College London (BJW), United Kingdom; Department of Urology, Frimley Park Hospital, Surrey (SRJB), United Kingdom; GlaxoSmithKline Research and Development (RC), Philadelphia, Pennsylvania; Institut National de la Santé et de la Recherche Médicale, U1099 and Laboratoire Traitement du Signal et de l'Image, Université de Rennes 1, Rennes (GG), France. Electronic address: caroline.moore@ucl.ac.uk.
authors.forename: Caroline M
authors.initials: CM
authors.lastname: Moore
authors.affiliation: Division of Surgery and Interventional Science (CMM, NLR, AD, AJR, HUA, MA, ME), University College London, United Kingdom; Biostatistics Group, University College London Hospitals/University College London Research Support Centre (FJ, GA), University College London, United Kingdom; Department of Urology, University College London Hospitals National Health Service Foundation Trust (CMM, NLR, AD, AJR, HUA, MA, NM, ME), United Kingdom; Department of Radiology (FG, CA), University College London Hospital Trust, United Kingdom; Department of Pathology (AF, CJ), University College London Hospital Trust, United Kingdom; Department of Urology, Charing Cross Hospital, Imperial College National Health Service Trust (MW), United Kingdom; Department of Clinical Oncology, University College Hospital London (AVM), United Kingdom; Klarismo (BJW), United Kingdom; Department of Mathematics, Imperial College London (BJW), United Kingdom; Department of Urology, Frimley Park Hospital, Surrey (SRJB), United Kingdom; GlaxoSmithKline Research and Development (RC), Philadelphia, Pennsylvania; Institut National de la Santé et de la Recherche Médicale, U1099 and Laboratoire Traitement du Signal et de l'Image, Université de Rennes 1, Rennes (GG), France.
authors.forename: Nicola L
authors.initials: NL
authors.lastname: Robertson
authors.affiliation: Division of Surgery and Interventional Science (CMM, NLR, AD, AJR, HUA, MA, ME), University College London, United Kingdom; Biostatistics Group, University College London Hospitals/University College London Research Support Centre (FJ, GA), University College London, United Kingdom; Department of Urology, University College London Hospitals National Health Service Foundation Trust (CMM, NLR, AD, AJR, HUA, MA, NM, ME), United Kingdom; Department of Radiology (FG, CA), University College London Hospital Trust, United Kingdom; Department of Pathology (AF, CJ), University College London Hospital Trust, United Kingdom; Department of Urology, Charing Cross Hospital, Imperial College National Health Service Trust (MW), United Kingdom; Department of Clinical Oncology, University College Hospital London (AVM), United Kingdom; Klarismo (BJW), United Kingdom; Department of Mathematics, Imperial College London (BJW), United Kingdom; Department of Urology, Frimley Park Hospital, Surrey (SRJB), United Kingdom; GlaxoSmithKline Research and Development (RC), Philadelphia, Pennsylvania; Institut National de la Santé et de la Recherche Médicale, U1099 and Laboratoire Traitement du Signal et de l'Image, Université de Rennes 1, Rennes (GG), France.
authors.forename: Fatima
authors.initials: F
authors.lastname: Jichi
authors.affiliation: Division of Surgery and Interventional Science (CMM, NLR, AD, AJR, HUA, MA, ME), University College London, United Kingdom; Biostatistics Group, University College London Hospitals/University College London Research Support Centre (FJ, GA), University College London, United Kingdom; Department of Urology, University College London Hospitals National Health Service Foundation Trust (CMM, NLR, AD, AJR, HUA, MA, NM, ME), United Kingdom; Department of Radiology (FG, CA), University College London Hospital Trust, United Kingdom; Department of Pathology (AF, CJ), University College London Hospital Trust, United Kingdom; Department of Urology, Charing Cross Hospital, Imperial College National Health Service Trust (MW), United Kingdom; Department of Clinical Oncology, University College Hospital London (AVM), United Kingdom; Klarismo (BJW), United Kingdom; Department of Mathematics, Imperial College London (BJW), United Kingdom; Department of Urology, Frimley Park Hospital, Surrey (SRJB), United Kingdom; GlaxoSmithKline Research and Development (RC), Philadelphia, Pennsylvania; Institut National de la Santé et de la Recherche Médicale, U1099 and Laboratoire Traitement du Signal et de l'Image, Université de Rennes 1, Rennes (GG), France.
authors.forename: Adebiyi
authors.initials: A
authors.lastname: Damola
authors.affiliation: Division of Surgery and Interventional Science (CMM, NLR, AD, AJR, HUA, MA, ME), University College London, United Kingdom; Biostatistics Group, University College London Hospitals/University College London Research Support Centre (FJ, GA), University College London, United Kingdom; Department of Urology, University College London Hospitals National Health Service Foundation Trust (CMM, NLR, AD, AJR, HUA, MA, NM, ME), United Kingdom; Department of Radiology (FG, CA), University College London Hospital Trust, United Kingdom; Department of Pathology (AF, CJ), University College London Hospital Trust, United Kingdom; Department of Urology, Charing Cross Hospital, Imperial College National Health Service Trust (MW), United Kingdom; Department of Clinical Oncology, University College Hospital London (AVM), United Kingdom; Klarismo (BJW), United Kingdom; Department of Mathematics, Imperial College London (BJW), United Kingdom; Department of Urology, Frimley Park Hospital, Surrey (SRJB), United Kingdom; GlaxoSmithKline Research and Development (RC), Philadelphia, Pennsylvania; Institut National de la Santé et de la Recherche Médicale, U1099 and Laboratoire Traitement du Signal et de l'Image, Université de Rennes 1, Rennes (GG), France.
authors.forename: Gareth
authors.initials: G
authors.lastname: Ambler
authors.affiliation: Division of Surgery and Interventional Science (CMM, NLR, AD, AJR, HUA, MA, ME), University College London, United Kingdom; Biostatistics Group, University College London Hospitals/University College London Research Support Centre (FJ, GA), University College London, United Kingdom; Department of Urology, University College London Hospitals National Health Service Foundation Trust (CMM, NLR, AD, AJR, HUA, MA, NM, ME), United Kingdom; Department of Radiology (FG, CA), University College London Hospital Trust, United Kingdom; Department of Pathology (AF, CJ), University College London Hospital Trust, United Kingdom; Department of Urology, Charing Cross Hospital, Imperial College National Health Service Trust (MW), United Kingdom; Department of Clinical Oncology, University College Hospital London (AVM), United Kingdom; Klarismo (BJW), United Kingdom; Department of Mathematics, Imperial College London (BJW), United Kingdom; Department of Urology, Frimley Park Hospital, Surrey (SRJB), United Kingdom; GlaxoSmithKline Research and Development (RC), Philadelphia, Pennsylvania; Institut National de la Santé et de la Recherche Médicale, U1099 and Laboratoire Traitement du Signal et de l'Image, Université de Rennes 1, Rennes (GG), France.
authors.forename: Francesco
authors.initials: F
authors.lastname: Giganti
authors.affiliation: Division of Surgery and Interventional Science (CMM, NLR, AD, AJR, HUA, MA, ME), University College London, United Kingdom; Biostatistics Group, University College London Hospitals/University College London Research Support Centre (FJ, GA), University College London, United Kingdom; Department of Urology, University College London Hospitals National Health Service Foundation Trust (CMM, NLR, AD, AJR, HUA, MA, NM, ME), United Kingdom; Department of Radiology (FG, CA), University College London Hospital Trust, United Kingdom; Department of Pathology (AF, CJ), University College London Hospital Trust, United Kingdom; Department of Urology, Charing Cross Hospital, Imperial College National Health Service Trust (MW), United Kingdom; Department of Clinical Oncology, University College Hospital London (AVM), United Kingdom; Klarismo (BJW), United Kingdom; Department of Mathematics, Imperial College London (BJW), United Kingdom; Department of Urology, Frimley Park Hospital, Surrey (SRJB), United Kingdom; GlaxoSmithKline Research and Development (RC), Philadelphia, Pennsylvania; Institut National de la Santé et de la Recherche Médicale, U1099 and Laboratoire Traitement du Signal et de l'Image, Université de Rennes 1, Rennes (GG), France.
authors.forename: Ashley J
authors.initials: AJ
authors.lastname: Ridout
authors.affiliation: Division of Surgery and Interventional Science (CMM, NLR, AD, AJR, HUA, MA, ME), University College London, United Kingdom; Biostatistics Group, University College London Hospitals/University College London Research Support Centre (FJ, GA), University College London, United Kingdom; Department of Urology, University College London Hospitals National Health Service Foundation Trust (CMM, NLR, AD, AJR, HUA, MA, NM, ME), United Kingdom; Department of Radiology (FG, CA), University College London Hospital Trust, United Kingdom; Department of Pathology (AF, CJ), University College London Hospital Trust, United Kingdom; Department of Urology, Charing Cross Hospital, Imperial College National Health Service Trust (MW), United Kingdom; Department of Clinical Oncology, University College Hospital London (AVM), United Kingdom; Klarismo (BJW), United Kingdom; Department of Mathematics, Imperial College London (BJW), United Kingdom; Department of Urology, Frimley Park Hospital, Surrey (SRJB), United Kingdom; GlaxoSmithKline Research and Development (RC), Philadelphia, Pennsylvania; Institut National de la Santé et de la Recherche Médicale, U1099 and Laboratoire Traitement du Signal et de l'Image, Université de Rennes 1, Rennes (GG), France.
authors.forename: Simon R J
authors.initials: SR
authors.lastname: Bott
authors.affiliation: Division of Surgery and Interventional Science (CMM, NLR, AD, AJR, HUA, MA, ME), University College London, United Kingdom; Biostatistics Group, University College London Hospitals/University College London Research Support Centre (FJ, GA), University College London, United Kingdom; Department of Urology, University College London Hospitals National Health Service Foundation Trust (CMM, NLR, AD, AJR, HUA, MA, NM, ME), United Kingdom; Department of Radiology (FG, CA), University College London Hospital Trust, United Kingdom; Department of Pathology (AF, CJ), University College London Hospital Trust, United Kingdom; Department of Urology, Charing Cross Hospital, Imperial College National Health Service Trust (MW), United Kingdom; Department of Clinical Oncology, University College Hospital London (AVM), United Kingdom; Klarismo (BJW), United Kingdom; Department of Mathematics, Imperial College London (BJW), United Kingdom; Department of Urology, Frimley Park Hospital, Surrey (SRJB), United Kingdom; GlaxoSmithKline Research and Development (RC), Philadelphia, Pennsylvania; Institut National de la Santé et de la Recherche Médicale, U1099 and Laboratoire Traitement du Signal et de l'Image, Université de Rennes 1, Rennes (GG), France.
authors.forename: Mathias
authors.initials: M
authors.lastname: Winkler
authors.affiliation: Division of Surgery and Interventional Science (CMM, NLR, AD, AJR, HUA, MA, ME), University College London, United Kingdom; Biostatistics Group, University College London Hospitals/University College London Research Support Centre (FJ, GA), University College London, United Kingdom; Department of Urology, University College London Hospitals National Health Service Foundation Trust (CMM, NLR, AD, AJR, HUA, MA, NM, ME), United Kingdom; Department of Radiology (FG, CA), University College London Hospital Trust, United Kingdom; Department of Pathology (AF, CJ), University College London Hospital Trust, United Kingdom; Department of Urology, Charing Cross Hospital, Imperial College National Health Service Trust (MW), United Kingdom; Department of Clinical Oncology, University College Hospital London (AVM), United Kingdom; Klarismo (BJW), United Kingdom; Department of Mathematics, Imperial College London (BJW), United Kingdom; Department of Urology, Frimley Park Hospital, Surrey (SRJB), United Kingdom; GlaxoSmithKline Research and Development (RC), Philadelphia, Pennsylvania; Institut National de la Santé et de la Recherche Médicale, U1099 and Laboratoire Traitement du Signal et de l'Image, Université de Rennes 1, Rennes (GG), France.
authors.forename: Hashim U
authors.initials: HU
authors.lastname: Ahmed
authors.affiliation: Division of Surgery and Interventional Science (CMM, NLR, AD, AJR, HUA, MA, ME), University College London, United Kingdom; Biostatistics Group, University College London Hospitals/University College London Research Support Centre (FJ, GA), University College London, United Kingdom; Department of Urology, University College London Hospitals National Health Service Foundation Trust (CMM, NLR, AD, AJR, HUA, MA, NM, ME), United Kingdom; Department of Radiology (FG, CA), University College London Hospital Trust, United Kingdom; Department of Pathology (AF, CJ), University College London Hospital Trust, United Kingdom; Department of Urology, Charing Cross Hospital, Imperial College National Health Service Trust (MW), United Kingdom; Department of Clinical Oncology, University College Hospital London (AVM), United Kingdom; Klarismo (BJW), United Kingdom; Department of Mathematics, Imperial College London (BJW), United Kingdom; Department of Urology, Frimley Park Hospital, Surrey (SRJB), United Kingdom; GlaxoSmithKline Research and Development (RC), Philadelphia, Pennsylvania; Institut National de la Santé et de la Recherche Médicale, U1099 and Laboratoire Traitement du Signal et de l'Image, Université de Rennes 1, Rennes (GG), France.
authors.forename: Manit
authors.initials: M
authors.lastname: Arya
authors.affiliation: Division of Surgery and Interventional Science (CMM, NLR, AD, AJR, HUA, MA, ME), University College London, United Kingdom; Biostatistics Group, University College London Hospitals/University College London Research Support Centre (FJ, GA), University College London, United Kingdom; Department of Urology, University College London Hospitals National Health Service Foundation Trust (CMM, NLR, AD, AJR, HUA, MA, NM, ME), United Kingdom; Department of Radiology (FG, CA), University College London Hospital Trust, United Kingdom; Department of Pathology (AF, CJ), University College London Hospital Trust, United Kingdom; Department of Urology, Charing Cross Hospital, Imperial College National Health Service Trust (MW), United Kingdom; Department of Clinical Oncology, University College Hospital London (AVM), United Kingdom; Klarismo (BJW), United Kingdom; Department of Mathematics, Imperial College London (BJW), United Kingdom; Department of Urology, Frimley Park Hospital, Surrey (SRJB), United Kingdom; GlaxoSmithKline Research and Development (RC), Philadelphia, Pennsylvania; Institut National de la Santé et de la Recherche Médicale, U1099 and Laboratoire Traitement du Signal et de l'Image, Université de Rennes 1, Rennes (GG), France.
authors.forename: Anita V
authors.initials: AV
authors.lastname: Mitra
authors.affiliation: Division of Surgery and Interventional Science (CMM, NLR, AD, AJR, HUA, MA, ME), University College London, United Kingdom; Biostatistics Group, University College London Hospitals/University College London Research Support Centre (FJ, GA), University College London, United Kingdom; Department of Urology, University College London Hospitals National Health Service Foundation Trust (CMM, NLR, AD, AJR, HUA, MA, NM, ME), United Kingdom; Department of Radiology (FG, CA), University College London Hospital Trust, United Kingdom; Department of Pathology (AF, CJ), University College London Hospital Trust, United Kingdom; Department of Urology, Charing Cross Hospital, Imperial College National Health Service Trust (MW), United Kingdom; Department of Clinical Oncology, University College Hospital London (AVM), United Kingdom; Klarismo (BJW), United Kingdom; Department of Mathematics, Imperial College London (BJW), United Kingdom; Department of Urology, Frimley Park Hospital, Surrey (SRJB), United Kingdom; GlaxoSmithKline Research and Development (RC), Philadelphia, Pennsylvania; Institut National de la Santé et de la Recherche Médicale, U1099 and Laboratoire Traitement du Signal et de l'Image, Université de Rennes 1, Rennes (GG), France.
authors.forename: Neil
authors.initials: N
authors.lastname: McCartan
authors.affiliation: Division of Surgery and Interventional Science (CMM, NLR, AD, AJR, HUA, MA, ME), University College London, United Kingdom; Biostatistics Group, University College London Hospitals/University College London Research Support Centre (FJ, GA), University College London, United Kingdom; Department of Urology, University College London Hospitals National Health Service Foundation Trust (CMM, NLR, AD, AJR, HUA, MA, NM, ME), United Kingdom; Department of Radiology (FG, CA), University College London Hospital Trust, United Kingdom; Department of Pathology (AF, CJ), University College London Hospital Trust, United Kingdom; Department of Urology, Charing Cross Hospital, Imperial College National Health Service Trust (MW), United Kingdom; Department of Clinical Oncology, University College Hospital London (AVM), United Kingdom; Klarismo (BJW), United Kingdom; Department of Mathematics, Imperial College London (BJW), United Kingdom; Department of Urology, Frimley Park Hospital, Surrey (SRJB), United Kingdom; GlaxoSmithKline Research and Development (RC), Philadelphia, Pennsylvania; Institut National de la Santé et de la Recherche Médicale, U1099 and Laboratoire Traitement du Signal et de l'Image, Université de Rennes 1, Rennes (GG), France.
authors.forename: Alex
authors.initials: A
authors.lastname: Freeman
authors.affiliation: Division of Surgery and Interventional Science (CMM, NLR, AD, AJR, HUA, MA, ME), University College London, United Kingdom; Biostatistics Group, University College London Hospitals/University College London Research Support Centre (FJ, GA), University College London, United Kingdom; Department of Urology, University College London Hospitals National Health Service Foundation Trust (CMM, NLR, AD, AJR, HUA, MA, NM, ME), United Kingdom; Department of Radiology (FG, CA), University College London Hospital Trust, United Kingdom; Department of Pathology (AF, CJ), University College London Hospital Trust, United Kingdom; Department of Urology, Charing Cross Hospital, Imperial College National Health Service Trust (MW), United Kingdom; Department of Clinical Oncology, University College Hospital London (AVM), United Kingdom; Klarismo (BJW), United Kingdom; Department of Mathematics, Imperial College London (BJW), United Kingdom; Department of Urology, Frimley Park Hospital, Surrey (SRJB), United Kingdom; GlaxoSmithKline Research and Development (RC), Philadelphia, Pennsylvania; Institut National de la Santé et de la Recherche Médicale, U1099 and Laboratoire Traitement du Signal et de l'Image, Université de Rennes 1, Rennes (GG), France.
authors.forename: Charles
authors.initials: C
authors.lastname: Jameson
authors.affiliation: Division of Surgery and Interventional Science (CMM, NLR, AD, AJR, HUA, MA, ME), University College London, United Kingdom; Biostatistics Group, University College London Hospitals/University College London Research Support Centre (FJ, GA), University College London, United Kingdom; Department of Urology, University College London Hospitals National Health Service Foundation Trust (CMM, NLR, AD, AJR, HUA, MA, NM, ME), United Kingdom; Department of Radiology (FG, CA), University College London Hospital Trust, United Kingdom; Department of Pathology (AF, CJ), University College London Hospital Trust, United Kingdom; Department of Urology, Charing Cross Hospital, Imperial College National Health Service Trust (MW), United Kingdom; Department of Clinical Oncology, University College Hospital London (AVM), United Kingdom; Klarismo (BJW), United Kingdom; Department of Mathematics, Imperial College London (BJW), United Kingdom; Department of Urology, Frimley Park Hospital, Surrey (SRJB), United Kingdom; GlaxoSmithKline Research and Development (RC), Philadelphia, Pennsylvania; Institut National de la Santé et de la Recherche Médicale, U1099 and Laboratoire Traitement du Signal et de l'Image, Université de Rennes 1, Rennes (GG), France.
authors.forename: Ramiro
authors.initials: R
authors.lastname: Castro
authors.affiliation: Division of Surgery and Interventional Science (CMM, NLR, AD, AJR, HUA, MA, ME), University College London, United Kingdom; Biostatistics Group, University College London Hospitals/University College London Research Support Centre (FJ, GA), University College London, United Kingdom; Department of Urology, University College London Hospitals National Health Service Foundation Trust (CMM, NLR, AD, AJR, HUA, MA, NM, ME), United Kingdom; Department of Radiology (FG, CA), University College London Hospital Trust, United Kingdom; Department of Pathology (AF, CJ), University College London Hospital Trust, United Kingdom; Department of Urology, Charing Cross Hospital, Imperial College National Health Service Trust (MW), United Kingdom; Department of Clinical Oncology, University College Hospital London (AVM), United Kingdom; Klarismo (BJW), United Kingdom; Department of Mathematics, Imperial College London (BJW), United Kingdom; Department of Urology, Frimley Park Hospital, Surrey (SRJB), United Kingdom; GlaxoSmithKline Research and Development (RC), Philadelphia, Pennsylvania; Institut National de la Santé et de la Recherche Médicale, U1099 and Laboratoire Traitement du Signal et de l'Image, Université de Rennes 1, Rennes (GG), France.
authors.forename: Giulio
authors.initials: G
authors.lastname: Gambarota
authors.affiliation: Division of Surgery and Interventional Science (CMM, NLR, AD, AJR, HUA, MA, ME), University College London, United Kingdom; Biostatistics Group, University College London Hospitals/University College London Research Support Centre (FJ, GA), University College London, United Kingdom; Department of Urology, University College London Hospitals National Health Service Foundation Trust (CMM, NLR, AD, AJR, HUA, MA, NM, ME), United Kingdom; Department of Radiology (FG, CA), University College London Hospital Trust, United Kingdom; Department of Pathology (AF, CJ), University College London Hospital Trust, United Kingdom; Department of Urology, Charing Cross Hospital, Imperial College National Health Service Trust (MW), United Kingdom; Department of Clinical Oncology, University College Hospital London (AVM), United Kingdom; Klarismo (BJW), United Kingdom; Department of Mathematics, Imperial College London (BJW), United Kingdom; Department of Urology, Frimley Park Hospital, Surrey (SRJB), United Kingdom; GlaxoSmithKline Research and Development (RC), Philadelphia, Pennsylvania; Institut National de la Santé et de la Recherche Médicale, U1099 and Laboratoire Traitement du Signal et de l'Image, Université de Rennes 1, Rennes (GG), France.
authors.forename: Brandon J
authors.initials: BJ
authors.lastname: Whitcher
authors.affiliation: Division of Surgery and Interventional Science (CMM, NLR, AD, AJR, HUA, MA, ME), University College London, United Kingdom; Biostatistics Group, University College London Hospitals/University College London Research Support Centre (FJ, GA), University College London, United Kingdom; Department of Urology, University College London Hospitals National Health Service Foundation Trust (CMM, NLR, AD, AJR, HUA, MA, NM, ME), United Kingdom; Department of Radiology (FG, CA), University College London Hospital Trust, United Kingdom; Department of Pathology (AF, CJ), University College London Hospital Trust, United Kingdom; Department of Urology, Charing Cross Hospital, Imperial College National Health Service Trust (MW), United Kingdom; Department of Clinical Oncology, University College Hospital London (AVM), United Kingdom; Klarismo (BJW), United Kingdom; Department of Mathematics, Imperial College London (BJW), United Kingdom; Department of Urology, Frimley Park Hospital, Surrey (SRJB), United Kingdom; GlaxoSmithKline Research and Development (RC), Philadelphia, Pennsylvania; Institut National de la Santé et de la Recherche Médicale, U1099 and Laboratoire Traitement du Signal et de l'Image, Université de Rennes 1, Rennes (GG), France.
authors.forename: Clare
authors.initials: C
authors.lastname: Allen
authors.affiliation: Division of Surgery and Interventional Science (CMM, NLR, AD, AJR, HUA, MA, ME), University College London, United Kingdom; Biostatistics Group, University College London Hospitals/University College London Research Support Centre (FJ, GA), University College London, United Kingdom; Department of Urology, University College London Hospitals National Health Service Foundation Trust (CMM, NLR, AD, AJR, HUA, MA, NM, ME), United Kingdom; Department of Radiology (FG, CA), University College London Hospital Trust, United Kingdom; Department of Pathology (AF, CJ), University College London Hospital Trust, United Kingdom; Department of Urology, Charing Cross Hospital, Imperial College National Health Service Trust (MW), United Kingdom; Department of Clinical Oncology, University College Hospital London (AVM), United Kingdom; Klarismo (BJW), United Kingdom; Department of Mathematics, Imperial College London (BJW), United Kingdom; Department of Urology, Frimley Park Hospital, Surrey (SRJB), United Kingdom; GlaxoSmithKline Research and Development (RC), Philadelphia, Pennsylvania; Institut National de la Santé et de la Recherche Médicale, U1099 and Laboratoire Traitement du Signal et de l'Image, Université de Rennes 1, Rennes (GG), France.
authors.forename: Alex
authors.initials: A
authors.lastname: Kirkham
authors.affiliation: Division of Surgery and Interventional Science (CMM, NLR, AD, AJR, HUA, MA, ME), University College London, United Kingdom; Biostatistics Group, University College London Hospitals/University College London Research Support Centre (FJ, GA), University College London, United Kingdom; Department of Urology, University College London Hospitals National Health Service Foundation Trust (CMM, NLR, AD, AJR, HUA, MA, NM, ME), United Kingdom; Department of Radiology (FG, CA), University College London Hospital Trust, United Kingdom; Department of Pathology (AF, CJ), University College London Hospital Trust, United Kingdom; Department of Urology, Charing Cross Hospital, Imperial College National Health Service Trust (MW), United Kingdom; Department of Clinical Oncology, University College Hospital London (AVM), United Kingdom; Klarismo (BJW), United Kingdom; Department of Mathematics, Imperial College London (BJW), United Kingdom; Department of Urology, Frimley Park Hospital, Surrey (SRJB), United Kingdom; GlaxoSmithKline Research and Development (RC), Philadelphia, Pennsylvania; Institut National de la Santé et de la Recherche Médicale, U1099 and Laboratoire Traitement du Signal et de l'Image, Université de Rennes 1, Rennes (GG), France.
authors.forename: Mark
authors.initials: M
authors.lastname: Emberton
mesh_terms: D058891:5-alpha Reductase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D004311:Double-Blind Method; D000068538:Dutasteride / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy* / Q000473:pathology; D047368:Tumor Burden / Q000187:drug effects
chemical_list: D058891:5-alpha Reductase Inhibitors; D000068538:Dutasteride
keywords: biopsy; dutasteride; magnetic resonance imaging; prostatic neoplasms; watchful waiting