title: Malignant Peripheral Nerve Sheath Tumor of Prostate: A Rare Case Report and Literature Review.
abstract: A mid-aged male presented with progressive lower urinary tract symptoms (LUTS) for years. Huge prostate with low serum prostate-specific antigen (PSA) level was detected. The specimen from transurethral resection revealed surprising pathology finding as malignant peripheral nerve sheath tumor (MPNST). Considering its huge size (more than 300 gm) and location, we prescribed neoadjuvant chemotherapy firstly. The tumor became regressive and then radical surgical resection was achieved. Adjuvant multimodality treatment including concurrent chemoradiotherapy (CCRT) and target therapy was given. However, he expired about one year later. MPNST originating from prostate is very rare and seldom reported before. We here present this extremely rare disease and share our treatment experience.
authors.affiliation: Divisions of Urology, Department of Surgery, Chi Mei Medical Center, Liuying, Tainan, Taiwan.
authors.forename: Kun-Lin
authors.identifier: 0000-0002-2492-9717
authors.initials: KL
authors.lastname: Hsieh
authors.affiliation: Divisions of Urology, Department of Surgery, Chi Mei Medical Center, Liuying, Tainan, Taiwan.
authors.forename: Chih-Cheng
authors.initials: CC
authors.lastname: Lu
authors.affiliation: Department of Pathology, Chi Mei Medical Center, Tainan, Taiwan.
authors.forename: Chien-Feng
authors.initials: CF
authors.lastname: Li
authors.affiliation: Division of Hematology and Oncology, Department of Internal Medicine, Chi Mei Medical Center, Tainan, Taiwan.
authors.forename: Yin-Hsun
authors.identifier: 0000-0002-8660-0685
authors.initials: YH
authors.lastname: Feng
authors.affiliation: Divisions of Urology, Department of Surgery, Chi Mei Medical Center, Tainan, Taiwan.
authors.forename: Alex C
authors.identifier: 0000-0003-4576-8577
authors.initials: AC
authors.lastname: Liao