title: Determination of ᴅ-phenylglycine in the presence of its ʟ-enantiomer using a turn-on fluorescent nano-chemosensor.
abstract: This paper reports on application of ʟ-tryptophan modified magnetite nanospheres (TryMNSs) as a novel fluorescent chiral selector for selective and sensitive determination of ᴅ-phenylglycine (ᴅ-Phy) in the presence of its enantiomer (i.e. ʟ-phenylglycine, ʟ-Phy). The results showed that the nanospheres could be used as a "turn-on" fluorescence nanosensor based on enhancement of its fluorescence peak intensity in the presence of ᴅ-Phy. Unlike its enantiomer, ʟ-Phy did not affect the nanosensor fluorescence behaviour suggesting that using the synthesized nanospheres selective determination of ᴅ-Phy in the presence of ʟ-Phy was achievable. The enhancing effect can be attributed to the initial formation of hydrogen-bonded complex followed by π-π interaction between the aromatic tryptophan moieties and ᴅ-Phy. After various affecting factors optimizing, the results showed that using the enhancing effect, selective and sensitive determination of ᴅ-Phy in the presence of ʟ-Phy in the concentration range of 0.5-200.0mgL-1with a detection limit as low as 190ngmL-1was achievable.
authors.affiliation: Faculty of Chemistry, Bu-Ali Sina University, Hamedan, Iran. Electronic address: m.ahmadi@basu.ac.ir.
authors.forename: Mazaher
authors.initials: M
authors.lastname: Ahmadi
authors.affiliation: Faculty of Chemistry, Bu-Ali Sina University, Hamedan, Iran.
authors.forename: Fariba
authors.initials: F
authors.lastname: Fazl
authors.affiliation: Faculty of Chemistry, Bu-Ali Sina University, Hamedan, Iran. Electronic address: madrakian@basu.ac.ir.
authors.forename: Tayyebeh
authors.initials: T
authors.lastname: Madrakian
authors.affiliation: Faculty of Chemistry, Bu-Ali Sina University, Hamedan, Iran.
authors.forename: Abbas
authors.initials: A
authors.lastname: Afkhami
mesh_terms: D052203:Ferrosoferric Oxide / Q000737:chemistry; D005453:Fluorescence; D005456:Fluorescent Dyes / Q000737:chemistry*; D005998:Glycine / Q000031:analogs & derivatives* / Q000032:analysis / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D046529:Microscopy, Electron, Transmission; D054118:Nanospheres / Q000737:chemistry* / Q000648:ultrastructure; D015203:Reproducibility of Results; D013010:Sonication; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods*; D013237:Stereoisomerism
chemical_list: D005456:Fluorescent Dyes; C021316:N-phenylglycine; D005998:Glycine; D052203:Ferrosoferric Oxide
keywords: Chiral chemosensor; Determination; Enantioselective recognition; Fluorescence; Magnetite nanospheres; ᴅ-phenylglycine