title: Noninvasive Support: Does It Really Decrease Bronchopulmonary Dysplasia?
abstract: Noninvasive support of preterm infants with respiratory distress is an evidenced-based strategy to decrease the incidence of bronchopulmonary dysplasia. Continuous positive airway pressure (CPAP) is the only noninvasive strategy with sufficient evidence to support its use in acute respiratory distress syndrome. It is unclear if one method for delivering CPAP is superior to another. Future research will focus on strategies (eg, sustained lung inflation, and administration of surfactant using a thin plastic catheter) that increase the likelihood of success with CPAP, especially in infants with a gestational age of less than 26 weeks.
authors.affiliation: Section of Neonatology, Department of Pediatrics, Perinatal Research Center, Children's Hospital Colorado, University of Colorado School of Medicine, Mail Stop F441, 13243 East 23rd Avenue, Aurora, CO 80045, USA. Electronic address: clyde.wright@ucdenver.edu.
authors.forename: Clyde J
authors.initials: CJ
authors.lastname: Wright
authors.affiliation: Department of Pediatrics, Morgan Stanley Children's Hospital, 3959 Broadway, New York, NY 10032, USA.
authors.forename: Richard A
authors.initials: RA
authors.lastname: Polin
mesh_terms: D001997:Bronchopulmonary Dysplasia / Q000453:epidemiology*; D045422:Continuous Positive Airway Pressure / Q000379:methods*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D063087:Noninvasive Ventilation / Q000379:methods*; D065840:Protective Factors; D011663:Pulmonary Surfactants / Q000627:therapeutic use*; D012127:Respiratory Distress Syndrome, Newborn / Q000628:therapy*; D012307:Risk Factors
chemical_list: D011663:Pulmonary Surfactants
keywords: BPD (bronchopulmonary dysplasia); CPAP (continuous positive airway pressure); High frequency ventilation; INSURE (INtubate, SURfactant, Extubate); Mechanical ventilation; SLI (sustained lung inflation); Ventilatory-induced lung injury; nCPAP (nasal CPAP)