title: New materials for sample preparation techniques in bioanalysis.
abstract: The analysis of biological samples is a complex and difficult task owing to two basic and complementary issues: the high complexity of most biological matrices and the need to determine minute quantities of active substances and contaminants in such complex sample. To succeed in this endeavor samples are usually subject to three steps of a comprehensive analytical methodological approach: sample preparation, analytes isolation (usually utilizing a chromatographic technique) and qualitative/quantitative analysis (usually with the aid of mass spectrometric tools). Owing to the complex nature of bio-samples, and the very low concentration of the target analytes to be determined, selective sample preparation techniques is mandatory in order to overcome the difficulties imposed by these two constraints. During the last decade new chemical synthesis approaches has been developed and optimized, such as sol-gel and molecularly imprinting technologies, allowing the preparation of novel materials for sample preparation including graphene and derivatives, magnetic materials, ionic liquids, molecularly imprinted polymers, and much more. In this contribution we will review these novel techniques and materials, as well as their application to the bioanalysis niche.
authors.affiliation: Federal University of Mato Grosso do Sul, Institute of Chemistry, Campo Grande, MS, Brazil.
authors.forename: Carlos Eduardo Domingues
authors.initials: CE
authors.lastname: Nazario
authors.affiliation: University of São Paulo, Institute of Chemistry at São Carlos, IQSC-USP, SP, Brazil.
authors.forename: Bruno Henrique
authors.initials: BH
authors.lastname: Fumes
authors.affiliation: University of São Paulo, Institute of Chemistry at São Carlos, IQSC-USP, SP, Brazil.
authors.forename: Meire Ribeiro
authors.initials: MR
authors.lastname: da Silva
authors.affiliation: University of São Paulo, Institute of Chemistry at São Carlos, IQSC-USP, SP, Brazil. Electronic address: flancas@colacro.org.
authors.forename: Fernando Mauro
authors.initials: FM
authors.lastname: Lanças
mesh_terms: D005591:Chemical Fractionation; D006108:Graphite; D052578:Ionic Liquids; D059346:Magnets; D054802:Molecular Imprinting; D044367:Phase Transition
chemical_list: D052578:Ionic Liquids; D006108:Graphite
keywords: Graphene; Ionic liquids; Magnetic materials; Molecularly imprinted polymer; Monolithic; Restricted access material; Sample preparation; Sol-gel; Sorbent materials