title: Does vertebral augmentation lead to an increasing incidence of adjacent vertebral failure? A systematic review and meta-analysis.
abstract: BACKGROUND
  The aim of the present study was to evaluate whether vertebral augmentation technology increases the occurrence of adjacent vertebral fractures in patients with osteoporotic vertebral compression fractures (OVCFs).
  
  
  METHODS
  Databases, including MEDLINE, EMBASE and Cochrane library, were retrieved via PRISMA covering 1987 to 2015. The number of patients who suffered from adjacent secondary vertebral fractures was calculated. A meta-analysis, using indexes of odds ratios (OR) and 95% confidence intervals (95% CI), was conducted with STATA software. Subgroup investigations were conducted according to the operation methods and the duration of observation. Sensitivity analysis and publication bias were also evaluated.
  
  
  RESULTS
  Ten randomized controlled trials (RCTs) met our inclusion criteria. Our results indicated there was no statistically significant difference in the occurrence rate of adjacent vertebral fractures between manipulation of vertebral augmentation and non-surgical treatment (OR = 0.89, 95% CI = 0.58-1.37). Neither subgroup investigations based on selection of operation nor duration of follow-up time showed marked differences. A sensitivity analysis did not identify specific trails seriously deflected. No obvious publication bias was identified.
  
  
  CONCLUSIONS
  Despite various limitations in the present study, our data demonstrated that using vertebral augmentation was not related to increasing incidence of subsequent adjacent vertebral fractures.
authors.affiliation: Department of Orthopedic Surgery, Tianjin Medical University General Hospital, Tianjin 300052, China.
authors.forename: Baoyou
authors.initials: B
authors.lastname: Fan
authors.affiliation: Department of Orthopedic Surgery, Tianjin Medical University General Hospital, Tianjin 300052, China.
authors.forename: Zhijian
authors.initials: Z
authors.lastname: Wei
authors.affiliation: Department of Orthopedic Surgery, Tianjin Medical University General Hospital, Tianjin 300052, China.
authors.forename: Xianhu
authors.initials: X
authors.lastname: Zhou
authors.affiliation: Department of Orthopedic Surgery, Tianjin Medical University General Hospital, Tianjin 300052, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Lin
authors.affiliation: Department of Orthopedic Surgery, Tianjin Medical University General Hospital, Tianjin 300052, China.
authors.forename: Yiming
authors.initials: Y
authors.lastname: Ren
authors.affiliation: Department of Orthopedic Surgery, Tianjin Medical University General Hospital, Tianjin 300052, China.
authors.forename: Ang
authors.initials: A
authors.lastname: Li
authors.affiliation: Department of Orthopedic Surgery, Tianjin Medical University General Hospital, Tianjin 300052, China.
authors.forename: Guidong
authors.initials: G
authors.lastname: Shi
authors.affiliation: Department of Orthopedic Surgery, Tianjin Medical University General Hospital, Tianjin 300052, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Hao
authors.affiliation: Department of Orthopedic Surgery, Tianjin Medical University General Hospital, Tianjin 300052, China.
authors.forename: Shen
authors.initials: S
authors.lastname: Liu
authors.affiliation: Department of Orthopedic Surgery, Tianjin Medical University General Hospital, Tianjin 300052, China.
authors.forename: Hengxing
authors.initials: H
authors.lastname: Zhou
authors.affiliation: Department of Orthopedic Surgery, Tianjin Medical University General Hospital, Tianjin 300052, China. Electronic address: sqfeng@tmu.edu.cn.
authors.forename: Shiqing
authors.initials: S
authors.lastname: Feng
mesh_terms: D050815:Fractures, Compression / Q000601:surgery*; D006801:Humans; D015994:Incidence; D058866:Osteoporotic Fractures / Q000601:surgery*; D016032:Randomized Controlled Trials as Topic; D016103:Spinal Fractures / Q000601:surgery*; D054854:Vertebroplasty
keywords: Adjacent vertebral failure; Meta-analysis; Systematic review; Vertebral augmentation