title: A new oleanolic-type triterpene glycoside from Anchusa italica.
abstract: A new oleanolic-type triterpene glycoside, (3β,21β)-21-[(β-d-glucopyranosyl-(1→2)-β-d-glucopyranosyl)oxy]-3-hydroxyolean-12-en-28-oic acid (1), together with five analogues, oleanazuroside 1 (2), oleanazuroside 2 (3), 24-hydroxytormentic acid ester glucoside (4), 24-epi-pinfaensin (5), and oleanolic acid 3-O-α-l-arabinoside (6) were isolated from the n-butyl alcohol extract of Anchusa italica. Their structures were determined spectroscopically and compared with previously reported spectral data. Compounds 3-4 and 6 were evaluated for their cytotoxic activities against five human cancer cell lines, but only compound 6 showed moderate cytotoxicity.
authors.affiliation: a Key Laboratory of Xinjiang Phytomedicine Resources, School of Pharmacy , Shihezi University , Shihezi , P.R. China.
authors.forename: Kui-Kui
authors.initials: KK
authors.lastname: Chen
authors.affiliation: a Key Laboratory of Xinjiang Phytomedicine Resources, School of Pharmacy , Shihezi University , Shihezi , P.R. China.
authors.forename: Zhou-Jian
authors.initials: ZJ
authors.lastname: Xie
authors.affiliation: a Key Laboratory of Xinjiang Phytomedicine Resources, School of Pharmacy , Shihezi University , Shihezi , P.R. China.
authors.forename: Wei
authors.initials: W
authors.lastname: Dai
authors.affiliation: a Key Laboratory of Xinjiang Phytomedicine Resources, School of Pharmacy , Shihezi University , Shihezi , P.R. China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Wang
mesh_terms: D018906:Antineoplastic Agents, Alkylating / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D028082:Boraginaceae / Q000737:chemistry*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D061986:MCF-7 Cells / Q000187:drug effects; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: C000619451:(3beta,21beta)-21-((beta-D-glucopyranosyl-(1-2)-beta-D-glucopyranosyl)oxy)-3-hydroxyolean-12-en-28-oic acid; C000619452:24-epi-pinfaensin; D018906:Antineoplastic Agents, Alkylating; D006027:Glycosides; D010936:Plant Extracts; D014315:Triterpenes; C000619377:oleanolic acid 3-O-alpha-L-arabinoside
keywords: Anchusa italica; Boraginaceae; cytotoxicity; triterpene glycoside