title: Racial and Ethnic Differences in the Epidemiology and Genomics of Lung Cancer.
abstract: BACKGROUND
  Lung cancer is the most common cancer in the world. In addition to the geographical and sex-specific differences in the incidence, mortality, and survival rates of lung cancer, growing evidence suggests that racial and ethnic differences exist.
  
  
  METHODS
  We reviewed published data related to racial and ethnic differences in lung cancer.
  
  
  RESULTS
  Current knowledge and substantive findings related to racial and ethnic differences in lung cancer were summarized, focusing on incidence, mortality, survival, cigarette smoking, prevention and early detection, and genomics. Systems-level and health care professional-related issues likely to contribute to specific racial and ethnic health disparities were also reviewed to provide possible suggestions for future strategies to reduce the disproportionate burden of lung cancer.
  
  
  CONCLUSIONS
  Although lung carcinogenesis is a multifactorial process driven by exogenous exposures, genetic variations, and an accumulation of somatic genetic events, it appears to have racial and ethnic differences that in turn impact the observed epidemiological differences in rates of incidence, mortality, and survival.
authors.affiliation: Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA. Matthew.Schabath@Moffitt.org.
authors.forename: Matthew B
authors.initials: MB
authors.lastname: Schabath
authors.forename: Douglas
authors.initials: D
authors.lastname: Cress
authors.forename: Teresita
authors.initials: T
authors.lastname: Munoz-Antonia
mesh_terms: D000368:Aged; D005006:Ethnicity; D005260:Female; D023281:Genomics; D006801:Humans; D008175:Lung Neoplasms / Q000453:epidemiology* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D015996:Survival Rate