title: Synovitis of sternoclavicular and peripheral joints can be detected by ultrasound in patients with SAPHO syndrome.
abstract: OBJECTIVE
  To determine the prevalence of ultrasonographic abnormalities of sternoclavicular joints (SCJ) and peripheral joints (PJ) in patients with synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome.
  
  
  METHODS
  Thirteen patients with SAPHO syndrome who fulfilled diagnostic criteria proposed by Kahn for SAPHO syndrome 2003 and 13 healthy individuals age- and sex-matched were enrolled. Synovitis, defined by synovial hypertrophy with power Doppler (PD) signals, of the SCJ and the PJ including wrist, MCP, PIP, and the other symptomatic joints were evaluated by ultrasound (US).
  
  
  RESULTS
  Synovitis with PD signals was detected in 16 (61.5%) of the 26 SCJ and 11 (84.6%) of the SAPHO syndrome patients, and none of the controls. Synovitis with PD signals in any PJ was detected in 4 (30.7%) of the SAPHO syndrome patients.
  
  
  CONCLUSIONS
  Synovitis of the SCJ and PJ in SAPHO syndrome was detectable by US with a PD method. US can be useful for the diagnosis of SAPHO syndrome.
authors.affiliation: a Department of Immunology and Rheumatology, Unit of Translational Medicine, Graduate School of Biomedical Sciences , Nagasaki University , Nagasaki , Japan.|b Department of Rheumatology , Sasebo Chuo Hospital , Sasebo , Japan.
authors.forename: Masataka
authors.initials: M
authors.lastname: Umeda
authors.affiliation: a Department of Immunology and Rheumatology, Unit of Translational Medicine, Graduate School of Biomedical Sciences , Nagasaki University , Nagasaki , Japan.|c Department of Community Medicine , and.
authors.forename: Shin-Ya
authors.initials: SY
authors.lastname: Kawashiri
authors.affiliation: a Department of Immunology and Rheumatology, Unit of Translational Medicine, Graduate School of Biomedical Sciences , Nagasaki University , Nagasaki , Japan.
authors.forename: Ayako
authors.initials: A
authors.lastname: Nishino
authors.affiliation: a Department of Immunology and Rheumatology, Unit of Translational Medicine, Graduate School of Biomedical Sciences , Nagasaki University , Nagasaki , Japan.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Koga
authors.affiliation: a Department of Immunology and Rheumatology, Unit of Translational Medicine, Graduate School of Biomedical Sciences , Nagasaki University , Nagasaki , Japan.
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Ichinose
authors.affiliation: a Department of Immunology and Rheumatology, Unit of Translational Medicine, Graduate School of Biomedical Sciences , Nagasaki University , Nagasaki , Japan.
authors.forename: Toru
authors.initials: T
authors.lastname: Michitsuji
authors.affiliation: a Department of Immunology and Rheumatology, Unit of Translational Medicine, Graduate School of Biomedical Sciences , Nagasaki University , Nagasaki , Japan.
authors.forename: Toshimasa
authors.initials: T
authors.lastname: Shimizu
authors.affiliation: a Department of Immunology and Rheumatology, Unit of Translational Medicine, Graduate School of Biomedical Sciences , Nagasaki University , Nagasaki , Japan.
authors.forename: Shoichi
authors.initials: S
authors.lastname: Fukui
authors.affiliation: a Department of Immunology and Rheumatology, Unit of Translational Medicine, Graduate School of Biomedical Sciences , Nagasaki University , Nagasaki , Japan.
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Nakashima
authors.affiliation: a Department of Immunology and Rheumatology, Unit of Translational Medicine, Graduate School of Biomedical Sciences , Nagasaki University , Nagasaki , Japan.
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Hirai
authors.affiliation: a Department of Immunology and Rheumatology, Unit of Translational Medicine, Graduate School of Biomedical Sciences , Nagasaki University , Nagasaki , Japan.
authors.forename: Naoki
authors.initials: N
authors.lastname: Iwamoto
authors.affiliation: b Department of Rheumatology , Sasebo Chuo Hospital , Sasebo , Japan.
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Aramaki
authors.affiliation: a Department of Immunology and Rheumatology, Unit of Translational Medicine, Graduate School of Biomedical Sciences , Nagasaki University , Nagasaki , Japan.
authors.forename: Mami
authors.initials: M
authors.lastname: Tamai
authors.affiliation: a Department of Immunology and Rheumatology, Unit of Translational Medicine, Graduate School of Biomedical Sciences , Nagasaki University , Nagasaki , Japan.
authors.forename: Hideki
authors.initials: H
authors.lastname: Nakamura
authors.affiliation: d Department Rehabilitation Sciences, Graduate School of Biomedical Sciences , Nagasaki University , Nagasaki , Japan.
authors.forename: Tomoki
authors.initials: T
authors.lastname: Origuchi
authors.affiliation: b Department of Rheumatology , Sasebo Chuo Hospital , Sasebo , Japan.
authors.forename: Yukitaka
authors.initials: Y
authors.lastname: Ueki
authors.affiliation: a Department of Immunology and Rheumatology, Unit of Translational Medicine, Graduate School of Biomedical Sciences , Nagasaki University , Nagasaki , Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kawakami
mesh_terms: D020083:Acquired Hyperostosis Syndrome / Q000175:diagnosis / Q000503:physiopathology; D000328:Adult; D005260:Female; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D013247:Sternoclavicular Joint / Q000000981:diagnostic imaging / Q000473:pathology; D013585:Synovitis / Q000175:diagnosis / Q000209:etiology; D014463:Ultrasonography / Q000379:methods / Q000706:statistics & numerical data
keywords: Power Doppler; SAPHO syndrome; Sternoclavicular joints; Ultrasonography