title: Clinical vascular imaging in the brain at 7T.
abstract: Stroke and related cerebrovascular diseases are a major cause of mortality and disability. Even at standard-field-strengths (1.5T), MRI is by far the most sensitive imaging technique to detect acute brain infarctions and to characterize incidental cerebrovascular lesions, such as white matter hyperintensities, lacunes and microbleeds. Arterial time-of-flight (TOF) MR angiography (MRA) can depict luminal narrowing or occlusion of the major brain feeding arteries, and this without the need for contrast administration. Compared to 1.5T MRA, the use of high-field strength (3T) and even more so ultra-high-field strengths (7T), enables the visualization of the lumen of much smaller intracranial vessels, while adding a contrast agent to TOF MRA at 7T may enable the visualization of even more distal arteries in addition to veins and venules. Moreover, with 3T and 7T, the arterial vessel walls beyond the circle of Willis become visible with high-resolution vessel wall imaging. In addition, with 7T MRI, the brain parenchyma can now be visualized on a submillimeter scale. As a result, high-resolution imaging studies of the brain and its blood supply at 7T have generated new concepts of different cerebrovascular diseases. In the current article, we will discuss emerging clinical applications and future directions of vascular imaging in the brain at 7T MRI.
authors.affiliation: Department of Radiology, University Medical Center Utrecht, The Netherlands; Department of Radiology, Kliniek Sint-Jan, Brussels, Belgium. Electronic address: laurens_de_cocker@hotmail.com.
authors.forename: Laurens Jl
authors.initials: LJ
authors.lastname: De Cocker
authors.affiliation: Department of Radiology, University Medical Center Utrecht, The Netherlands.
authors.forename: Arjen
authors.initials: A
authors.lastname: Lindenholz
authors.affiliation: Department of Radiology, University Medical Center Utrecht, The Netherlands.
authors.forename: Jaco Jm
authors.initials: JJ
authors.lastname: Zwanenburg
authors.affiliation: Department of Radiology, University Medical Center Utrecht, The Netherlands.
authors.forename: Anja G
authors.initials: AG
authors.lastname: van der Kolk
authors.affiliation: Department of Radiology, University Medical Center Utrecht, The Netherlands.
authors.forename: Maarten
authors.initials: M
authors.lastname: Zwartbol
authors.affiliation: Department of Radiology, University Medical Center Utrecht, The Netherlands.
authors.forename: Peter R
authors.initials: PR
authors.lastname: Luijten
authors.affiliation: Department of Radiology, University Medical Center Utrecht, The Netherlands.
authors.forename: Jeroen
authors.initials: J
authors.lastname: Hendrikse
mesh_terms: D001921:Brain / Q000098:blood supply* / Q000000981:diagnostic imaging* / Q000473:pathology; D002561:Cerebrovascular Disorders / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods* / Q000592:standards; D059906:Neuroimaging / Q000379:methods* / Q000592:standards