title: Bcl-2 protein family expression pattern determines synergistic pro-apoptotic effects of BH3 mimetics with hemisynthetic cardiac glycoside UNBS1450 in acute myeloid leukemia.
authors.affiliation: Laboratoire de Biologie Moléculaire et Cellulaire du Cancer, Hôpital Kirchberg, Luxembourg City, Luxembourg.
authors.forename: C
authors.initials: C
authors.lastname: Cerella
authors.affiliation: Laboratoire de Biologie Moléculaire et Cellulaire du Cancer, Hôpital Kirchberg, Luxembourg City, Luxembourg.
authors.forename: A
authors.initials: A
authors.lastname: Gaigneaux
authors.affiliation: Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul, Korea.
authors.forename: A
authors.initials: A
authors.lastname: Mazumder
authors.affiliation: Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul, Korea.
authors.forename: J-Y
authors.initials: JY
authors.lastname: Lee
authors.affiliation: Cancer Research Center of Toulouse, UMR 1037 INSERM/Université Toulouse III-Paul Sabatier, Oncopole, Toulouse, France.
authors.forename: E
authors.initials: E
authors.lastname: Saland
authors.affiliation: Laboratoire de Biologie Moléculaire et Cellulaire du Cancer, Hôpital Kirchberg, Luxembourg City, Luxembourg.
authors.forename: F
authors.initials: F
authors.lastname: Radogna
authors.affiliation: Cancer Research Center of Toulouse, UMR 1037 INSERM/Université Toulouse III-Paul Sabatier, Oncopole, Toulouse, France.
authors.forename: T
authors.initials: T
authors.lastname: Farge
authors.affiliation: Cancer Research Center of Toulouse, UMR 1037 INSERM/Université Toulouse III-Paul Sabatier, Oncopole, Toulouse, France.|Université Toulouse III-Paul Sabatier, Toulouse, France.
authors.forename: F
authors.initials: F
authors.lastname: Vergez
authors.affiliation: Cancer Research Center of Toulouse, UMR 1037 INSERM/Université Toulouse III-Paul Sabatier, Oncopole, Toulouse, France.|Université Toulouse III-Paul Sabatier, Toulouse, France.|Service d'Hématologie, Centre Hospitalier Universitaire de Toulouse, Institut Universitaire du Cancer de Toulouse Oncopole, Toulouse, France.
authors.forename: C
authors.initials: C
authors.lastname: Récher
authors.affiliation: Cancer Research Center of Toulouse, UMR 1037 INSERM/Université Toulouse III-Paul Sabatier, Oncopole, Toulouse, France.
authors.forename: J-E
authors.initials: JE
authors.lastname: Sarry
authors.affiliation: SNU-Harvard Neurovascular Protection Center, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Korea.
authors.forename: K-W
authors.initials: KW
authors.lastname: Kim
authors.affiliation: Department of Pediatrics, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: H Y
authors.initials: HY
authors.lastname: Shin
authors.affiliation: Laboratoire de Biologie Moléculaire et Cellulaire du Cancer, Hôpital Kirchberg, Luxembourg City, Luxembourg.
authors.forename: M
authors.initials: M
authors.lastname: Dicato
authors.affiliation: Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul, Korea.
authors.forename: M
authors.initials: M
authors.lastname: Diederich
mesh_terms: D017209:Apoptosis / Q000187:drug effects*; D051017:Apoptosis Regulatory Proteins / Q000378:metabolism; D002298:Cardenolides / Q000494:pharmacology*; D002301:Cardiac Glycosides / Q000494:pharmacology*; D045744:Cell Line, Tumor; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy* / Q000378:metabolism; D064549:Myeloid Cell Leukemia Sequence 1 Protein / Q000378:metabolism; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism*; D020298:U937 Cells; D051020:bcl-X Protein / Q000378:metabolism
chemical_list: D051017:Apoptosis Regulatory Proteins; C000595707:BCL2 protein, human; D002298:Cardenolides; D002301:Cardiac Glycosides; D064549:Myeloid Cell Leukemia Sequence 1 Protein; D019253:Proto-Oncogene Proteins c-bcl-2; C510008:UNBS 1450; D051020:bcl-X Protein