title: The possible role of interleukin-35 and its therapeutic potential in pemphigus.
abstract: Pemphigus is an autoimmune disease that causes blistering and is life-threatening if left untreated. Nowadays, finding a promising treatment for pemphigus remains a serious challenge. Various treatments are currently recommended to treat this disease, but they rarely lead to complete and durable remission. Regulatory cells appear to have a critical role in numerous autoimmune diseases, so it is possible that promotion of these cells may induce remission. This study presents a new approach to treating pemphigus that has not been discussed to date. This approach introduces interleukin (IL)-35 as a new treatment for pemphigus. This cytokine could induce two different types of regulatory cell, including IL-35-that produces induced regulatory T cells and IL-35+regulatory B cells, which could suppress both effector T cells and effector B cells. It seems that IL-35 may act as an efficient therapeutic strategy for pemphigus. It probably limits progression of the disease and may even contribute to long-lasting remission. However, further study is required to evaluate the efficacy and safety of treating pemphigus with IL-35.
authors.affiliation: Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: soheil.tavakolpour@gmail.com.
authors.forename: Soheil
authors.initials: S
authors.lastname: Tavakolpour
authors.affiliation: Islamic Azad University of Tehran Medical Science branch, Iran.
authors.forename: Forough
authors.initials: F
authors.lastname: Kheiry
authors.affiliation: Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Hajar Sadat
authors.initials: HS
authors.lastname: Mirsafaei
authors.affiliation: Pars Advanced and Minimally Invasive Manners Research Center, Pars Hospital, Tehran, Iran.
authors.forename: Meisam
authors.initials: M
authors.lastname: Akhlaghdoust
mesh_terms: D000818:Animals; D060151:B-Lymphocytes, Regulatory / Q000276:immunology*; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D007378:Interleukins / Q000276:immunology*; D010392:Pemphigus / Q000276:immunology* / Q000628:therapy; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
chemical_list: D007378:Interleukins; C532417:interleukin-35, human
keywords: Effector T cell; Interleukin 35; Pemphigus; Regulatory B cell; iTr35