title: Latent structure of cognitive performance in the adult children study.
abstract: OBJECTIVE
  The Adult Children Study (ACS) at the Knight Alzheimer's Disease Research Center is a longitudinal investigation designed to identify and validate potential biomarkers of preclinical Alzheimer's disease (AD) in cognitively normal individuals with and without a family history of AD. The purpose of the current study was to validate the proposed latent structure of the ACS psychometric battery.
  
  
  METHODS
  Confirmatory factor analyses of baseline data in a sample of 229 (75 men) cognitively normal middle-aged to older adult individuals assessed a hypothesized 4-factor model of cognitive performance. Measurement invariance was investigated as a function of family history of AD and apolipoprotein E (APOE) status.
  
  
  RESULTS
  This study confirmed a priori hypotheses of 4 latent cognitive domains in a unique longitudinal sample of cognitively normal adults. In addition, there was evidence of a similar factor structure for family history and APOE status groups.
  
  
  CONCLUSIONS
  These robust indicators of a broad range of cognitive domains will be used in future investigations to track the influence of family history of AD on cognitive performance over time. In addition, associations with fluid, structural, and molecular biomarkers of preclinical AD will be further examined, both cross-sectionally and longitudinally in this sample.
authors.affiliation: a Department of Psychological and Brain Sciences , Washington University in St. Louis , St. Louis , MO , USA.|b Knight Alzheimer's Disease Research Center , Washington University in St. Louis , St. Louis , MO , USA.|d Department of Radiology , Washington University in St. Louis , St. Louis , MO , USA.
authors.forename: Denise
authors.initials: D
authors.lastname: Head
authors.affiliation: a Department of Psychological and Brain Sciences , Washington University in St. Louis , St. Louis , MO , USA.
authors.forename: Samantha
authors.initials: S
authors.lastname: Allison
authors.affiliation: a Department of Psychological and Brain Sciences , Washington University in St. Louis , St. Louis , MO , USA.
authors.forename: Nathaniel
authors.initials: N
authors.lastname: Lucena
authors.affiliation: a Department of Psychological and Brain Sciences , Washington University in St. Louis , St. Louis , MO , USA.|b Knight Alzheimer's Disease Research Center , Washington University in St. Louis , St. Louis , MO , USA.|c Department of Neurology , Washington University in St. Louis , St. Louis , MO , USA.
authors.forename: Jason
authors.initials: J
authors.lastname: Hassenstab
authors.affiliation: b Knight Alzheimer's Disease Research Center , Washington University in St. Louis , St. Louis , MO , USA.|c Department of Neurology , Washington University in St. Louis , St. Louis , MO , USA.
authors.forename: John C
authors.initials: JC
authors.lastname: Morris
mesh_terms: D032721:Adult Children; D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis*; D015415:Biomarkers; D005163:Factor Analysis, Statistical; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011594:Psychometrics / Q000295:instrumentation*
chemical_list: D015415:Biomarkers
keywords: Cognitive aging; Confirmatory factor analysis; Measurement invariance; Psychometric test battery