title: [MRI/TRUS fusion-guided prostate biopsy : Value in the context of focal therapy].
abstract: BACKGROUND
  Several systems for MRI/TRUS fusion-guided biopsy of the prostate are commercially available. Many studies have shown superiority of fusion systems for tumor detection and diagnostic quality compared to random biopsy. The benefit of fusion systems in focal therapy of prostate cancer (PC) is less clear.
  
  
  OBJECTIVE
  Critical considerations of fusion systems for planning and monitoring of focal therapy of PC were investigated.
  
  
  METHODS
  A systematic literature review of available fusion systems for the period 2013-5/2016 was performed. A checklist of technical details, suitability for special anatomic situations and suitability for focal therapy was established by the German working group for focal therapy (Arbeitskreis fokale und Mikrotherapie).
  
  
  RESULTS
  Eight fusion systems were considered (Artemis™, BioJet, BiopSee®, iSR´obot™ Mona Lisa, Hitachi HI-RVS, UroNav and Urostation®). Differences were found for biopsy mode (transrectal, perineal, both), fusion mode (elastic or rigid), navigation (image-based, electromagnetic sensor-based or mechanical sensor-based) and space requirements.
  
  
  CONCLUSIONS
  Several consensus groups recommend fusion systems for focal therapy. Useful features are "needle tracking" and compatibility between fusion system and treatment device (available for Artemis™, BiopSee® and Urostation® with Focal One®; BiopSee®, Hitachi HI-RVS with NanoKnife®; BioJet, BiopSee® with cryoablation, brachytherapy).
  
  
  CONCLUSIONS
  There are a few studies for treatment planning. However, studies on treatment monitoring after focal therapy are missing.
authors.affiliation: Klinik und Poliklinik für Urologie, Universitätsklinikum Leipzig AöR, Liebigstr. 20, 04103, Leipzig, Deutschland.
authors.forename: T
authors.initials: T
authors.lastname: Franz
authors.affiliation: Klinik für Urologie, Universitätsmedizin Mannheim der Universität Heidelberg, Mannheim, Deutschland.
authors.forename: J
authors.initials: J
authors.lastname: von Hardenberg
authors.affiliation: Klinik für Urologie und Kinderurologie, Klinikum Fürth, Fürth, Deutschland.
authors.forename: A
authors.initials: A
authors.lastname: Blana
authors.affiliation: Klinik für Urologie, Charité - Universitätsmedizin Berlin, Berlin, Deutschland.
authors.forename: H
authors.initials: H
authors.lastname: Cash
authors.affiliation: Universitätsklinik für Urologie und Kinderurologie, Universität Magdeburg, Magdeburg, Deutschland.
authors.forename: D
authors.initials: D
authors.lastname: Baumunk
authors.affiliation: Martini-Klinik, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Deutschland.
authors.forename: G
authors.initials: G
authors.lastname: Salomon
authors.affiliation: Urologische Klinik, Universitätsklinikum Heidelberg, Heidelberg, Deutschland.
authors.forename: B
authors.initials: B
authors.lastname: Hadaschik
authors.affiliation: Praxis Urologie Britz, Berlin, Deutschland.
authors.forename: T
authors.initials: T
authors.lastname: Henkel
authors.affiliation: Klinik für Urologie, Universitätsmedizin Mannheim der Universität Heidelberg, Mannheim, Deutschland.
authors.forename: J
authors.initials: J
authors.lastname: Herrmann
authors.affiliation: Praxis Urologie Britz, Berlin, Deutschland.
authors.forename: F
authors.initials: F
authors.lastname: Kahmann
authors.affiliation: Abteilung für Urologie, Theresienkrankenhaus Mannheim, Mannheim, Deutschland.
authors.forename: K-U
authors.initials: KU
authors.lastname: Köhrmann
authors.affiliation: Institut für Pathologie, Sana Klinikum Offenbach, Offenbach, Deutschland.
authors.forename: J
authors.initials: J
authors.lastname: Köllermann
authors.affiliation: Klinik für Urologie, Universitätsklinikum Tübingen, Tübingen, Deutschland.
authors.forename: S
authors.initials: S
authors.lastname: Kruck
authors.affiliation: Universitätsklinik für Urologie und Kinderurologie, Universität Magdeburg, Magdeburg, Deutschland.
authors.forename: U-B
authors.initials: UB
authors.lastname: Liehr
authors.affiliation: Klinik für Urologie, Marien-Krankenhaus, Bergisch Gladbach, Deutschland.
authors.forename: S
authors.initials: S
authors.lastname: Machtens
authors.affiliation: Klinik für Urologie und Urologische Onkologie, Medizinische Hochschule Hannover, Hannover, Deutschland.
authors.forename: I
authors.initials: I
authors.lastname: Peters
authors.affiliation: Urologische Klinik, Universitätsklinikum Heidelberg, Heidelberg, Deutschland.
authors.forename: J P
authors.initials: JP
authors.lastname: Radtke
authors.affiliation: Klinik für Urologie, Augusta-Kranken-Anstalt GmbH, Bochum, Deutschland.
authors.forename: A
authors.initials: A
authors.lastname: Roosen
authors.affiliation: Abteilung für Radiologie, Deutsches Krebsforschungszentrum Heidelberg, Heidelberg, Deutschland.
authors.forename: H-P
authors.initials: HP
authors.lastname: Schlemmer
authors.affiliation: Zentrum f. Urologie Sinsheim/Walldorf/Wiesloch, Sinsheim, Deutschland.
authors.forename: L
authors.initials: L
authors.lastname: Sentker
authors.affiliation: Universitätsklinik für Urologie und Kinderurologie, Universität Magdeburg, Magdeburg, Deutschland.
authors.forename: J J
authors.initials: JJ
authors.lastname: Wendler
authors.affiliation: Klinik für Urologie und Kinderurologie, Klinikum Nordwest, Frankfurt am Main, Deutschland.
authors.forename: U
authors.initials: U
authors.lastname: Witzsch
authors.affiliation: Klinik und Poliklinik für Urologie, Universitätsklinikum Leipzig AöR, Liebigstr. 20, 04103, Leipzig, Deutschland.
authors.forename: J-U
authors.initials: JU
authors.lastname: Stolzenburg
authors.affiliation: Universitätsklinik für Urologie und Kinderurologie, Universität Magdeburg, Magdeburg, Deutschland.
authors.forename: M
authors.initials: M
authors.lastname: Schostak
authors.affiliation: Klinik und Poliklinik für Urologie, Universitätsklinikum Leipzig AöR, Liebigstr. 20, 04103, Leipzig, Deutschland. roman.ganzer@medizin.uni-leipzig.de.
authors.forename: R
authors.initials: R
authors.lastname: Ganzer
mesh_terms: D061765:Endoscopic Ultrasound-Guided Fine Needle Aspiration / Q000295:instrumentation*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000295:instrumentation*; D008297:Male; D064847:Multimodal Imaging / Q000295:instrumentation*; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000628:therapy*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013673:Technology Assessment, Biomedical
keywords: Focal therapy; Fusion biopsy; MRI; Prostate cancer; Targeted biopsy