title: 5-HT3 receptor antagonists for the prevention of postoperative shivering: a meta-analysis.
abstract: Objective We evaluated the efficacy of 5-HT3 receptor antagonists for the prevention of postoperative shivering. Methods We searched PubMed, the Cochrane Library, EMBASE and Web of Knowledge to find randomized controlled trials (RCT) of 5-HT3 receptor antagonists for the prevention of postoperative shivering. Two researchers independently screened studies, extracted data, and assessed quality in accordance with the inclusion and exclusion criteria, and then conducted a meta-analysis using RevMan 5.2. Results Ultimately, 14 RCTs that included 980 patients were included in the analysis. We found that: 1) the incidence of shivering was significantly lower in 5-HT3 groups than placebo groups (relative risk, [RR] = 0.48, 95% confidence interval [CI] 0.40 - 0.58); 2) there was no significant difference in the incidence of shivering between 5-HT3 groups and meperidine groups (RR = 0.89, 95% CI 0.60 - 1.34). Conclusion 5-HT3 receptor antagonists appear to prevent postoperative shivering, with a broadly comparable efficacy to meperidine.
authors.affiliation: 1 Department of Anesthesiology, Affiliated Tumor Hospital of Guangxi Medical University, Nanning 530021, China.|2 Department of Surgery, Zhaoqing Medical College, Zhaoqing 526000, China.
authors.forename: Chengmao
authors.initials: C
authors.lastname: Zhou
authors.affiliation: 2 Department of Surgery, Zhaoqing Medical College, Zhaoqing 526000, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: 1 Department of Anesthesiology, Affiliated Tumor Hospital of Guangxi Medical University, Nanning 530021, China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Liu
authors.affiliation: 1 Department of Anesthesiology, Affiliated Tumor Hospital of Guangxi Medical University, Nanning 530021, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Ruan
mesh_terms: D000701:Analgesics, Opioid / Q000627:therapeutic use; D017829:Granisetron / Q000627:therapeutic use; D006801:Humans; D007211:Indoles / Q000627:therapeutic use; D007546:Isoquinolines / Q000627:therapeutic use; D008614:Meperidine / Q000627:therapeutic use; D017294:Ondansetron / Q000627:therapeutic use; D000077924:Palonosetron; D011183:Postoperative Complications / Q000503:physiopathology / Q000517:prevention & control*; D011184:Postoperative Period; D011812:Quinuclidines / Q000627:therapeutic use; D016032:Randomized Controlled Trials as Topic; D044406:Receptors, Serotonin, 5-HT3 / Q000378:metabolism*; D058831:Serotonin 5-HT3 Receptor Antagonists / Q000627:therapeutic use*; D012768:Shivering / Q000187:drug effects* / Q000502:physiology; D013514:Surgical Procedures, Operative / Q000009:adverse effects*; D000077526:Tropisetron
chemical_list: D000701:Analgesics, Opioid; D017829:Granisetron; D007211:Indoles; D007546:Isoquinolines; D008614:Meperidine; D017294:Ondansetron; D000077924:Palonosetron; D011812:Quinuclidines; D044406:Receptors, Serotonin, 5-HT3; D058831:Serotonin 5-HT3 Receptor Antagonists; D000077526:Tropisetron
keywords: HT3 receptor antagonists; anesthesia; meperidine; meta-analysis; randomized controlled trial; shivering