title: Phenotypic and genotypic characterization of Chinese children diagnosed with tuberous sclerosis complex.
abstract: We investigated the clinical phenotypes and genetic mutations in Chinese children diagnosed with tuberous sclerosis complex (TSC). Sequencing of TSC1 and TSC2 genes was performed in 117 children with TSC and their parents. Association of TSC gene mutations with clinical manifestations was investigated. All gene mutations were heterozygous including in 16 patients (13.7%) with mutations in TSC1 gene and 101 patients (86.3%) with mutations in TSC2 gene. Among the 16 patients with TSC1 gene mutations, 15 different types of mutations were found, which included 5 novel mutations; all patients had skin manifestations and epilepsy. Among the 101 patients with TSC2 mutations, 85 different types of mutations were found, which included 25 novel mutations; 97 patients (96.0%) had skin manifestations; 97 (96.0%) had epilepsy; 74 (73.3%) had intellectual disability and 25 patients (24.8%) were autistic. The clinical phenotype of the 14 children with familial TSC was more severe than that of their parents.
authors.affiliation: Department of Pediatrics, Chinese PLA General Hospital, Beijing, China.
authors.forename: G
authors.initials: G
authors.lastname: Yang
authors.affiliation: Bethune Medical Academy, Shijiazhuang, China.
authors.forename: Z N
authors.initials: ZN
authors.lastname: Shi
authors.affiliation: Department of Pediatrics, Chinese PLA General Hospital, Beijing, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Meng
authors.affiliation: Department of Pediatrics, Chinese PLA General Hospital, Beijing, China.
authors.forename: X Y
authors.initials: XY
authors.lastname: Shi
authors.affiliation: Department of Pediatrics, Chinese PLA General Hospital, Beijing, China.
authors.forename: L Y
authors.initials: LY
authors.lastname: Pang
authors.affiliation: Department of Pediatrics, Chinese PLA General Hospital, Beijing, China.
authors.forename: S F
authors.initials: SF
authors.lastname: Ma
authors.affiliation: Department of Pediatrics, Chinese PLA General Hospital, Beijing, China.
authors.forename: M N
authors.initials: MN
authors.lastname: Zhang
authors.affiliation: Department of Pediatrics, Chinese PLA General Hospital, Beijing, China.
authors.forename: Y Y
authors.initials: YY
authors.lastname: Wang
authors.affiliation: Department of Pediatrics, Chinese PLA General Hospital, Beijing, China.|Beijing Institute for Brain Disorders, Beijing, China.
authors.forename: L P
authors.initials: LP
authors.lastname: Zou
mesh_terms: D044466:Asian People / Q000235:genetics; D001321:Autistic Disorder / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D004827:Epilepsy / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D008607:Intellectual Disability / Q000235:genetics; D008297:Male; D009154:Mutation; D010641:Phenotype; D014402:Tuberous Sclerosis / Q000209:etiology / Q000235:genetics*; D000077004:Tuberous Sclerosis Complex 1 Protein; D000077005:Tuberous Sclerosis Complex 2 Protein; D025521:Tumor Suppressor Proteins / Q000235:genetics*
chemical_list: C000624650:TSC1 protein, human; C000624653:TSC2 protein, human; D000077004:Tuberous Sclerosis Complex 1 Protein; D000077005:Tuberous Sclerosis Complex 2 Protein; D025521:Tumor Suppressor Proteins
keywords: Chinese children; clinical manifestation; gene mutation; tuberous sclerosis complex (TSC)