title: Interruption of perivascular sympathetic nerves of cerebral arteries offers neuroprotection against ischemia.
abstract: Sympathetic nervous system activity is increased after cardiopulmonary arrest, resulting in vasoconstrictor release from the perivascular sympathetic nerves of cerebral arteries. However, the pathophysiological function of the perivascular sympathetic nerves in the ischemic brain remains unclear. A rat model of global cerebral ischemia (asphyxial cardiac arrest, ACA) was used to investigate perivascular sympathetic nerves of cerebral arteries via bilateral decentralization (preganglionic lesion) of the superior cervical ganglion (SCG). Decentralization of the SCG 5 days before ACA alleviated hypoperfusion and afforded hippocampal neuroprotection and improved functional outcomes. These studies can provide further insights into the functional mechanism(s) of the sympathetic nervous system during ischemia.
  Interruption of the perivascular sympathetic nerves can alleviate CA-induced hypoperfusion and neuronal cell death in the CA1 region of the hippocampus to enhance functional learning and memory.
authors.affiliation: Cerebral Vascular Disease Laboratories, University of Miami Miller School of Medicine, Miami, Florida.|Department of Neurology, University of Miami Miller School of Medicine, Miami, Florida.|Department of Neurology, Louisiana State University Health Sciences Center, Shreveport, Louisiana.
authors.forename: Reggie H
authors.identifier: http://orcid.org/0000-0001-6099-8333
authors.initials: RH
authors.lastname: Lee
authors.affiliation: Cerebral Vascular Disease Laboratories, University of Miami Miller School of Medicine, Miami, Florida.|Department of Neurology, University of Miami Miller School of Medicine, Miami, Florida.|Department of Neurology, Louisiana State University Health Sciences Center, Shreveport, Louisiana.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Couto E Silva
authors.affiliation: Cerebral Vascular Disease Laboratories, University of Miami Miller School of Medicine, Miami, Florida.|Department of Neurology, University of Miami Miller School of Medicine, Miami, Florida.
authors.forename: Francesca M
authors.initials: FM
authors.lastname: Lerner
authors.affiliation: Florida International University Herbert Wertheim College of Medicine, Miami, Florida.
authors.forename: Carl S
authors.initials: CS
authors.lastname: Wilkins
authors.affiliation: Cerebral Vascular Disease Laboratories, University of Miami Miller School of Medicine, Miami, Florida.|Department of Neurology, University of Miami Miller School of Medicine, Miami, Florida.
authors.forename: Stephen E
authors.initials: SE
authors.lastname: Valido
authors.affiliation: Cerebral Vascular Disease Laboratories, University of Miami Miller School of Medicine, Miami, Florida.|Department of Neurology, University of Miami Miller School of Medicine, Miami, Florida.
authors.forename: Daniel D
authors.initials: DD
authors.lastname: Klein
authors.affiliation: Department of Neurology, University of Miami Miller School of Medicine, Miami, Florida.|Department of Neurology, Louisiana State University Health Sciences Center, Shreveport, Louisiana.
authors.forename: Celeste Y
authors.initials: CY
authors.lastname: Wu
authors.affiliation: Department of Biomedical Sciences, West Virginia School of Osteopathic Medicine, Lewisburg, West Virginia.
authors.forename: Jake T
authors.initials: JT
authors.lastname: Neumann
authors.affiliation: Department of Neurology, University of Miami Miller School of Medicine, Miami, Florida.|Department of Systems Medicine, University of Rome Tor Vergata; and.|IRCCS San Raffaele Pisana, Rome, Italy.
authors.forename: David
authors.initials: D
authors.lastname: Della-Morte
authors.affiliation: Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, Florida.
authors.forename: Stephen H
authors.initials: SH
authors.lastname: Koslow
authors.affiliation: Department of Neurology, Louisiana State University Health Sciences Center, Shreveport, Louisiana.
authors.forename: Alireza
authors.initials: A
authors.lastname: Minagar
authors.affiliation: Cerebral Vascular Disease Laboratories, University of Miami Miller School of Medicine, Miami, Florida; hlin2@lsuhsc.edu.|Department of Neurology, University of Miami Miller School of Medicine, Miami, Florida.|Department of Neurology, Louisiana State University Health Sciences Center, Shreveport, Louisiana.
authors.forename: Hung Wen
authors.initials: HW
authors.lastname: Lin
mesh_terms: D000818:Animals; D001237:Asphyxia / Q000209:etiology; D001921:Brain / Q000473:pathology / Q000503:physiopathology; D002545:Brain Ischemia / Q000473:pathology* / Q000503:physiopathology; D056547:CA1 Region, Hippocampal / Q000473:pathology* / Q000503:physiopathology; D016923:Cell Death; D002536:Cerebral Arteries / Q000294:innervation*; D004195:Disease Models, Animal; D006323:Heart Arrest / Q000150:complications; D007858:Learning / Q000502:physiology; D008297:Male; D008568:Memory / Q000502:physiology; D018613:Microscopy, Confocal; D009474:Neurons / Q000473:pathology*; D000066829:Neuroprotection; D000069336:Neurovascular Coupling; D051381:Rats; D017207:Rats, Sprague-Dawley; D017783:Superior Cervical Ganglion; D013562:Sympathectomy; D013564:Sympathetic Nervous System
keywords: behavior (rodent); brain ischemia; cardiac arrest; cerebral blood flow; cerebral blood flow measurement; cognitive impairment; global ischemia; neuroprotection; pial vessels; sympathetic nervous system; two photon microscopy