title: Influence of Statin Therapy on Aneurysm Sac Regression after Endovascular Aortic Repair.
abstract: OBJECTIVE
  To determine whether statin therapy is associated with abdominal aortic aneurysm (AAA) sac regression after endovascular aneurysm repair (EVAR).
  
  
  METHODS
  A total of 109 patients treated with EVAR were retrospectively analyzed (no-statin group, n = 45; statin group, n = 64). The primary endpoint was the incidence of AAA sac regression. To investigate independent predictors of AAA sac regression, regression analysis was performed. The mean age was 74 years (range, 55-90 y), and 87.2% of patients were men.
  
  
  RESULTS
  The no-statin group had higher rates of AAA sac regression than the statin group at 1 year (no-statin group, 66.7%; statin group, 45.3%; P = .028). The incidence of AAA sac regression increased over time in the statin group, and no statistical difference was seen between the two groups at 2 years (no-statin group, 66.7%; statin group, 57.8%; P = .350). The difference between the changes in maximum AAA diameter was significant between groups at 1 year (no-statin group vs statin group, -4.9 mm ± 5.9; P = .041), but the difference did not reach statistical significance at 2 years (no-statin group, -10.0 mm ± 10.1; statin group, -8.0 mm ± 9.6; P = .306). Statin therapy was not associated with AAA sac regression on univariate (odds ratio [OR], 0.685; 95% confidence interval [CI], 0.310-1.516; P = .351) and multivariate analyses (OR, 0.617; 95% CI, 0.215-1.772; P = .369).
  
  
  CONCLUSIONS
  Statin therapy had no effect on AAA sac regression at 2 years. There is insufficient evidence to recommend statin therapy for AAA sac regression.
authors.affiliation: Division of Interventional Radiology, Miami Cardiac and Vascular Institute, Miami, Florida; Department of Medical and Population Health Sciences Research, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida; Division of Cardiology, Eulji University Hospital, Eulji University School of Medicine, Daejeon, Republic of Korea.
authors.forename: Wonho
authors.initials: W
authors.lastname: Kim
authors.affiliation: Division of Interventional Radiology, Miami Cardiac and Vascular Institute, Miami, Florida.
authors.forename: Ripal T
authors.initials: RT
authors.lastname: Gandhi
authors.affiliation: Division of Interventional Radiology, Miami Cardiac and Vascular Institute, Miami, Florida.
authors.forename: Constantino S
authors.initials: CS
authors.lastname: Peña
authors.affiliation: Division of Interventional Radiology, Miami Cardiac and Vascular Institute, Miami, Florida.
authors.forename: Raul E
authors.initials: RE
authors.lastname: Herrera
authors.affiliation: Division of Interventional Radiology, Miami Cardiac and Vascular Institute, Miami, Florida.
authors.forename: Melanie B
authors.initials: MB
authors.lastname: Schernthaner
authors.affiliation: Department of Medical and Population Health Sciences Research, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida.
authors.forename: Juan M
authors.initials: JM
authors.lastname: Acuña
authors.affiliation: Department of Medical and Population Health Sciences Research, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida.
authors.forename: Victor N
authors.initials: VN
authors.lastname: Becerra
authors.affiliation: Division of Interventional Radiology, Miami Cardiac and Vascular Institute, Miami, Florida. Electronic address: btkatzen@aol.com.
authors.forename: Barry T
authors.initials: BT
authors.lastname: Katzen
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D017544:Aortic Aneurysm, Abdominal / Q000000981:diagnostic imaging / Q000601:surgery*; D001027:Aortography / Q000379:methods; D019917:Blood Vessel Prosthesis Implantation / Q000009:adverse effects; D000072226:Computed Tomography Angiography; D057510:Endovascular Procedures / Q000009:adverse effects; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors