title: Results of a Multicenter, Randomized, Controlled Trial of a Hydrogen Peroxide-based Kit versus a Benzoyl Peroxide-based Kit in Mild-to-moderate Acne.
abstract: Objective:To evaluate the efficacy and tolerability of a novel hydrogen peroxide-based regimen versus a benzoyl peroxide-based regimen in mild-to-moderate acne.Methods:In this eight-week multicenter study, patients were randomized to either a hydrogen peroxide-based or a benzoyl peroxide-based regimen.The primary outcome measure of clinical response was assessed using the Global Acne Grading System (GAGS) at baseline,four weeks, and eight weeks. At Week 8, a patient self-satisfaction questionnaire was administered. Investigators were also queried at that time regarding assessment of tolerability and cosmetic acceptability. Tolerability was also measured at each visit.Results:Both treatment regimens were associated with improvement of GAGS score at Week 8 compared to baseline (p<0.0001). GAGS score did not differ significantly between the two regimens over the same period (p=0.7765). No significant adverse events were reported or observed in either treatment arm. Both patients and investigators found both regimens to be similarly effective and cosmetically acceptable.Conclusion:A novel hydrogen peroxide-based regimen was shown to be comparable in efficacy, safety, and cosmetic acceptability to a benzoyl peroxide-based regimen in the treatment of mild-to-moderate acne.
authors.affiliation: Department of Pathophysiology and Transplantation, Università degli Studi di Milano, I.R.C.C.S. Foundation, Cà Granda Ospedale Maggiore Policlinico, Milan, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Veraldi
authors.affiliation: Section of Dermatology, Department of Medical and Surgical Specialties, University of Catania, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Micali
authors.affiliation: San Gallicano Dermatological Institute, Rome, Italy.
authors.forename: Enzo
authors.initials: E
authors.lastname: Berardesca
authors.affiliation: Section of Dermatology, Department of Medical and Surgical Specialties, University of Catania, Italy.
authors.forename: Federica
authors.initials: F
authors.lastname: Dall'Oglio
authors.affiliation: San Gallicano Dermatological Institute, Rome, Italy.
authors.forename: Jo Linda
authors.initials: JL
authors.lastname: Sinagra
authors.affiliation: Department of Pathophysiology and Transplantation, Università degli Studi di Milano, I.R.C.C.S. Foundation, Cà Granda Ospedale Maggiore Policlinico, Milan, Italy.
authors.forename: Elena
authors.initials: E
authors.lastname: Guanziroli