title: Laser irradiation to produce amorphous pharmaceuticals.
abstract: Using a high-power CO2laser to irradiate powder beds, it was possible to induce phase transformation to the amorphous state. Irradiation of a model drug, indometacin, resulted in formation of a glass. Varying the settings of the laser (power and raster speed) was shown to change the physicochemical properties of the glasses produced and all irradiated glasses were found to be more stable than a reference glass produced by melt-quenching. Irradiation of a powder blend of paracetamol and polyvinylpyrrolidone K30 was found to produce a solid amorphous dispersion. The results suggest that laser-irradiation might be a useful method for making amorphous pharmaceuticals.
authors.affiliation: UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London, WC1N 1AX, UK.
authors.forename: Varin
authors.initials: V
authors.lastname: Titapiwatanakun
authors.affiliation: UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London, WC1N 1AX, UK.
authors.forename: Junlathip
authors.initials: J
authors.lastname: Tankul
authors.affiliation: UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London, WC1N 1AX, UK.
authors.forename: Abdul W
authors.initials: AW
authors.lastname: Basit
authors.affiliation: UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London, WC1N 1AX, UK. Electronic address: s.gaisford@ucl.ac.uk.
authors.forename: Simon
authors.initials: S
authors.lastname: Gaisford
mesh_terms: D002626:Chemistry, Pharmaceutical / Q000379:methods; D004355:Drug Stability; D005139:Eyeglasses; D007213:Indomethacin / Q000737:chemistry*; D007834:Lasers; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D011205:Povidone / Q000737:chemistry; D011208:Powders / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000379:methods*
chemical_list: D004364:Pharmaceutical Preparations; D011208:Powders; D011205:Povidone; D007213:Indomethacin
keywords: Amorphous; CO(2) laser; Indomethacin; PVP K30; Paracetamol; Phase-transformation; Solid amorphous dispersion