title: 25 Years of Proton Pump Inhibitors: A Comprehensive Review.
abstract: Proton pump inhibitors (PPIs) were clinically introduced more than 25 years ago and have since proven to be invaluable, safe, and effective agents for the management of a variety of acid-related disorders. Although all members in this class act in a similar fashion, inhibiting active parietal cell acid secretion, there are slight differences among PPIs relating to their pharmacokinetic properties, metabolism, and Food and Drug Administration (FDA)-approved clinical indications. Nevertheless, each is effective in managing gastroesophageal reflux disease and uncomplicated or complicated peptic ulcer disease. Despite their overall efficacy, PPIs do have some limitations related to their short plasma half-lives and requirement for meal-associated dosing, which can lead to breakthrough symptoms in some individuals, especially at night. Longer-acting PPIs and technology to prolong conventional PPI activity have been developed to specifically address these limitations and may improve clinical outcomes.
authors.affiliation: Division of Gastroenterology and Hepatology, University of Virginia, Charlottesville, VA, USA.
authors.forename: Daniel S
authors.initials: DS
authors.lastname: Strand
authors.affiliation: Division of Gastroenterology, Daegu Fatima Hospital, Daegu, Korea.
authors.forename: Daejin
authors.initials: D
authors.lastname: Kim
authors.affiliation: Division of Gastroenterology and Hepatology, University of Virginia, Charlottesville, VA, USA.
authors.forename: David A
authors.initials: DA
authors.lastname: Peura
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects; D004359:Drug Therapy, Combination; D005764:Gastroesophageal Reflux / Q000188:drug therapy*; D006207:Half-Life; D016481:Helicobacter Infections / Q000188:drug therapy; D006801:Humans; D010437:Peptic Ulcer / Q000139:chemically induced / Q000188:drug therapy* / Q000517:prevention & control; D054328:Proton Pump Inhibitors / Q000493:pharmacokinetics / Q000627:therapeutic use*
chemical_list: D000900:Anti-Bacterial Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D054328:Proton Pump Inhibitors
keywords: Indications; Pharmacokinetics; Proton pump inhibitors; Review; Risk