title: Metabolomic Approach in Probing Drug Candidates.
abstract: Metabolomics is the comprehensive characterization of endogenous small molecules metabolites, xenometabolites and their metabolisms. The recent introduction of high-throughput metabolomics approaches has fostered strides related to the capacity to in silico elaborate metabolomics data by means of system biology. Recent progresses in bioanalytical technologies assisted with algorithms enabling large-scale data analysis potentiate application of metabolomics approaches in biomarker- based disease diagnosis, therapeutic target identification, personalized medicine, and the monitoring of clinical outcomes. In this review article we will focus on recent applications of metabolomics approaches in the identification of potential therapeutic candidates based on our and others' confirmed experience with this cutting-edge technology.
authors.affiliation: Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston, Houston, TX, United States.
authors.forename: Chen
authors.initials: C
authors.lastname: Liu
authors.affiliation: Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, CO, United States.
authors.forename: Angelo D'
authors.initials: A
authors.lastname: Alessandro
authors.affiliation: Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston, TX, United States.
authors.forename: Yang
authors.initials: Y
authors.lastname: Xia
mesh_terms: D000755:Anemia, Sickle Cell / Q000378:metabolism; D050197:Atherosclerosis / Q000378:metabolism; D055808:Drug Discovery; D004912:Erythrocytes / Q000166:cytology / Q000473:pathology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000378:metabolism; D055432:Metabolomics; D009369:Neoplasms / Q000378:metabolism; D011225:Pre-Eclampsia / Q000378:metabolism; D011247:Pregnancy; D015427:Reperfusion Injury / Q000378:metabolism
keywords: Metabolomics; drug discovery; high-throughput screening; precision medicine; system biology; target validation