title: Genetic correlates of the development of theta event related oscillations in adolescents and young adults.
abstract: The developmental trajectories of theta band (4-7Hz) event-related oscillations (EROs), a key neurophysiological constituent of the P3 response, were assessed in 2170 adolescents and young adults ages 12 to 25. The theta EROs occurring in the P3 response, important indicators of neurocognitive function, were elicited during the evaluation of task-relevant target stimuli in visual and auditory oddball tasks. Associations between the theta EROs and genotypic variants of 4 KCNJ6 single nucleotide polymorphisms (SNPs) were found to vary with age, sex, scalp location, and task modality. Three of the four KCNJ6 SNPs studied here were found to be significantly associated with the same theta EROs in adults in a previous family genome wide association study. Since measures of the P3 response have been found to be a useful endophenotypes for the study of a number of clinical and behavioral disorders, studies of genetic effects on its development in adolescents and young adults may illuminate neurophysiological factors contributing to the onset of these conditions.
authors.affiliation: Henri Begleiter Neurodynamics Laboratory, Department of Psychiatry, SUNY Downstate Medical Center, Brooklyn, NY, USA. Electronic address: David.Chorlian@downstate.edu.
authors.forename: David B
authors.initials: DB
authors.lastname: Chorlian
authors.affiliation: Department of Psychology,Christ University, Bangalore, India.
authors.forename: Madhavi
authors.initials: M
authors.lastname: Rangaswamy
authors.affiliation: Department of Physics, College of Wooster, Wooster, OH, USA.
authors.forename: Niklas
authors.initials: N
authors.lastname: Manz
authors.affiliation: Henri Begleiter Neurodynamics Laboratory, Department of Psychiatry, SUNY Downstate Medical Center, Brooklyn, NY, USA.
authors.forename: Jacquelyn L
authors.initials: JL
authors.lastname: Meyers
authors.affiliation: Stratton VA Medical Center, Albany, NY, USA.
authors.forename: Sun J
authors.initials: SJ
authors.lastname: Kang
authors.affiliation: Henri Begleiter Neurodynamics Laboratory, Department of Psychiatry, SUNY Downstate Medical Center, Brooklyn, NY, USA.
authors.forename: Chella
authors.initials: C
authors.lastname: Kamarajan
authors.affiliation: Henri Begleiter Neurodynamics Laboratory, Department of Psychiatry, SUNY Downstate Medical Center, Brooklyn, NY, USA.
authors.forename: Ashwini K
authors.initials: AK
authors.lastname: Pandey
authors.affiliation: Mount Sinai School of Medicine, New York, NY, USA.
authors.forename: Jen-Chyong
authors.initials: JC
authors.lastname: Wang
authors.affiliation: Indiana University School of Medicine, Indianapolis, IN, USA.
authors.forename: Leah
authors.initials: L
authors.lastname: Wetherill
authors.affiliation: Indiana University School of Medicine, Indianapolis, IN, USA.
authors.forename: Howard
authors.initials: H
authors.lastname: Edenberg
authors.affiliation: Henri Begleiter Neurodynamics Laboratory, Department of Psychiatry, SUNY Downstate Medical Center, Brooklyn, NY, USA.
authors.forename: Bernice
authors.initials: B
authors.lastname: Porjesz
mesh_terms: D000161:Acoustic Stimulation; D000293:Adolescent; D000328:Adult; D000375:Aging / Q000502:physiology*; D000437:Alcoholism / Q000235:genetics; D002648:Child; D004569:Electroencephalography; D005260:Female; D051676:G Protein-Coupled Inwardly-Rectifying Potassium Channels / Q000235:genetics*; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008297:Male; D010641:Phenotype; D010775:Photic Stimulation; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011446:Prospective Studies; D012737:Sex Factors; D013826:Theta Rhythm / Q000235:genetics*; D055815:Young Adult
chemical_list: D051676:G Protein-Coupled Inwardly-Rectifying Potassium Channels; C094401:KCNJ6 protein, human
keywords: Adolescent; Development; ERO; KCNJ6; P3; Theta