title: QbD based synthesis and characterization of polyacrylamide grafted corn fibre gum.
abstract: The aim of present investigation was to utilize quality by design approach for the synthesis of polyacrylamide corn fibre gum (PAAm-g-CFG) from corn fibre gum (CFG) by varying concentration of acrylamide and initiator. The spectral analysis (ATR-FTIR,1H NMR, DSC, X-ray and Mass spectroscopy) was conducted to assure grafting copolymerization of CFG with acrylamide. The powder flow properties confirm the porous nature of PAAm-g-CFG. The grafted copolymer dispersion showed shear thinning behaviour that follows Herschel Bulkley model. The viscoelastic analysis suggested viscous liquid like nature of PAAm-g-CFG and its viscosity increases with increase in concentration of PAAm-g-CFG. The mucoadhesive strength of synthesized PAAm-g-CFG was found to be higher than moringa oleifera gum, karaya gum, guar gum, xanthan gum, chitosan and gelatin. Further, the results pointed toward enhanced thermal stability of PAAm-g-CFG. Thus, PAAm-g-CFG has a great potential to be used in food and pharmaceutical industry.
authors.affiliation: Pharmaceutics Division, Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala 147002, India.
authors.forename: Akashdeep
authors.initials: A
authors.lastname: Singh
authors.affiliation: Pharmaceutics Division, Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala 147002, India.
authors.forename: Bhumika
authors.initials: B
authors.lastname: Mangla
authors.affiliation: Pharmaceutics Division, Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala 147002, India.
authors.forename: Sheshank
authors.initials: S
authors.lastname: Sethi
authors.affiliation: Pharmaceutics Division, Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala 147002, India.
authors.forename: Sunil
authors.initials: S
authors.lastname: Kamboj
authors.affiliation: Pharmaceutics Division, Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala 147002, India.
authors.forename: Radhika
authors.initials: R
authors.lastname: Sharma
authors.affiliation: Pharmaceutics Division, Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala 147002, India. Electronic address: vikas_pbi@rediffmail.com.
authors.forename: Vikas
authors.initials: V
authors.lastname: Rana
mesh_terms: D000180:Acrylic Resins; D053149:Plant Gums / Q000737:chemistry*; D014783:Viscosity; D003313:Zea mays / Q000737:chemistry*; D000099166:Polyacrylamides
chemical_list: D000180:Acrylic Resins; D053149:Plant Gums; D000099166:Polyacrylamides
keywords: Grafted copolymer; Liquid like viscous gum; Mucoadhesion; Polyacrylamide corn fibre gum; Rheology