title: Mycobacterium shigaense Causes Lymph Node and Cutaneous Lesions as Immune Reconstitution Syndrome in an AIDS Patient: The Third Case Report of a Novel Strain Non-tuberculous Mycobacterium.
abstract: A 40-year-old man complaining of progressive body weight loss was diagnosed to have acquired immunodeficiency syndrome. Within 2 weeks after the initiation of combination antiretroviral therapy, he developed fever, massive cervical lymphadenopathy and a protruding subcutaneous abscess. A lymph node biopsy and abscess drainage revealed non-caseous granuloma and mycobacterium. The mycobacterium belonged to Runyon II group, but it showed no matches to any previously reported species. According to sequence analyses, the strain was identified as Mycobacterium shigaense. After six months of antimycobacterial treatment, the lesions were all successfully cured. This is the third case report of the novel mycobacterium, M. shigaense, presenting in associatioin with immune reconstitution syndrome.
authors.affiliation: Department of Clinical Infectious Diseases, Aichi Medical University Hospital, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Koizumi
authors.forename: Kaoru
authors.initials: K
authors.lastname: Shimizu
authors.forename: Masayo
authors.initials: M
authors.lastname: Shigeta
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Minamiguchi
authors.forename: Keiko
authors.initials: K
authors.lastname: Hodohara
authors.forename: Akira
authors.initials: A
authors.lastname: Andoh
authors.forename: Toshihide
authors.initials: T
authors.lastname: Tanaka
authors.forename: Kinuyo
authors.initials: K
authors.lastname: Chikamatsu
authors.forename: Satoshi
authors.initials: S
authors.lastname: Mitarai
authors.forename: Hiroshige
authors.initials: H
authors.lastname: Mikamo
mesh_terms: D000038:Abscess / Q000209:etiology*; D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D006801:Humans; D054019:Immune Reconstitution Inflammatory Syndrome / Q000150:complications / Q000175:diagnosis*; D000072281:Lymphadenopathy / Q000209:etiology*; D008297:Male; D009170:Nontuberculous Mycobacteria; D017192:Skin Diseases, Bacterial / Q000209:etiology*