title: Cancer Cell Drug Response Transcriptomes in 3D.
abstract: The relevance of different in vitro culture models of cancer cells is a hot topic, but few systematic and definitive analyses in this area exist. In this issue of Cell Chemical Biology, Senkowski et al. (2016) address this issue by studying the transcriptomic profiles of drug-treated cancer cells cultured in two-dimensional and three-dimensional cultures. They describe biological findings with potential therapeutic implications and provide a unique data resource to mine.
authors.affiliation: Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00290 Helsinki, Finland. Electronic address: krister.wennerberg@fimm.fi.
authors.forename: Krister
authors.initials: K
authors.lastname: Wennerberg
mesh_terms: D018929:Cell Culture Techniques; D020869:Gene Expression Profiling; D006801:Humans; D009369:Neoplasms; D018874:Spheroids, Cellular; D059467:Transcriptome