title: Visual and Quantitative Analysis Methods of Respiratory Patterns for Respiratory Gated PET/CT.
abstract: We integrated visual and quantitative methods for analyzing the stability of respiration using four methods: phase space diagrams, Fourier spectra, Poincaré maps, and Lyapunov exponents. Respiratory patterns of 139 patients were grouped based on the combination of the regularity of amplitude, period, and baseline positions. Visual grading was done by inspecting the shape of diagram and classified into two states: regular and irregular. Quantitation was done by measuring standard deviation ofxandvcoordinates of Poincaré map (SDx, SDv) or the height of the fundamental peak (A1) in Fourier spectrum or calculating the difference between maximal upward and downward drift. Each group showed characteristic pattern on visual analysis. There was difference of quantitative parameters (SDx, SDv,A1, and MUD-MDD) among four groups (one way ANOVA,p= 0.0001 for MUD-MDD, SDx, and SDv,p= 0.0002 forA1). In ROC analysis, the cutoff values were 0.11 for SDx(AUC: 0.982,p< 0.0001), 0.062 for SDv(AUC: 0.847,p< 0.0001), 0.117 forA1(AUC: 0.876,p< 0.0001), and 0.349 for MUD-MDD (AUC: 0.948,p< 0.0001). This is the first study to analyze multiple aspects of respiration using various mathematical constructs and provides quantitative indices of respiratory stability and determining quantitative cutoff value for differentiating regular and irregular respiration.
authors.affiliation: Department of Nuclear Medicine, Dong-A University Medical Center, Dong-A University College of Medicine, Busan, Republic of Korea.
authors.forename: Hye Joo
authors.identifier: 0000-0003-1290-0949
authors.initials: HJ
authors.lastname: Son
authors.affiliation: Department of Nuclear Medicine, Dong-A University Medical Center, Dong-A University College of Medicine, Busan, Republic of Korea.
authors.forename: Young Jin
authors.identifier: 0000-0001-7611-8185
authors.initials: YJ
authors.lastname: Jeong
authors.affiliation: Department of Nuclear Medicine, Dong-A University Medical Center, Dong-A University College of Medicine, Busan, Republic of Korea.
authors.forename: Hyun Jin
authors.initials: HJ
authors.lastname: Yoon
authors.affiliation: The Dong-A Anti-Aging Research Institute, Dong-A University, Busan, Republic of Korea.
authors.forename: Jong-Hwan
authors.identifier: 0000-0003-2815-7248
authors.initials: JH
authors.lastname: Park
authors.affiliation: Department of Nuclear Medicine, Dong-A University Medical Center, Dong-A University College of Medicine, Busan, Republic of Korea; The Dong-A Anti-Aging Research Institute, Dong-A University, Busan, Republic of Korea.
authors.forename: Do-Young
authors.identifier: 0000-0003-1688-0818
authors.initials: DY
authors.lastname: Kang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000072078:Positron Emission Tomography Computed Tomography / Q000379:methods*; D012372:ROC Curve; D012143:Respiratory Physiological Phenomena; D055425:Respiratory-Gated Imaging Techniques / Q000379:methods*