title: Outcomes after primary or adjuvant radiotherapy for salivary gland carcinoma.
abstract: BACKGROUND
  We report long-term outcomes of patients treated with primary radiotherapy (RT) or surgery and adjuvant RT for salivary gland malignancies.
  
  
  METHODS
  From 1964 to 2012, 291 patients received primary RT (n = 67) or RT combined with surgery (n = 224).
  
  
  RESULTS
  The 5-, 10-, and 15-year local control, local-regional control, distant metastasis-free survival, cause-specific survival and overall survival rates were 82%, 77% and 73%; 77%, 72% and 67%; 74%, 70% and 70%; 70%, 59% and 54%; and 63%, 47% and 38%, respectively. Per multivariate analysis, combined surgery and RT and T stage impacted local control; overall stage and combined surgery and RT impacted local-regional control; overall stage impacted distant metastasis-free survival; and overall stage, node positivity, clinical nerve invasion, and surgery and RT impacted cause-specific and overall survival. Five percent of patients experienced grade 3 or worse toxicity.
  
  
  CONCLUSIONS
  Combined surgery and RT improves local control, local-regional control, and cause-specific survival compared with primary RT for salivary tumors.
authors.affiliation: a Department of Radiation Oncology , University of Florida College of Medicine , Gainesville , FL , USA.
authors.forename: Adam
authors.initials: A
authors.lastname: Holtzman
authors.affiliation: a Department of Radiation Oncology , University of Florida College of Medicine , Gainesville , FL , USA.
authors.forename: Christopher G
authors.initials: CG
authors.lastname: Morris
authors.affiliation: a Department of Radiation Oncology , University of Florida College of Medicine , Gainesville , FL , USA.
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Amdur
authors.affiliation: b Department of Otolaryngology , University of Florida College of Medicine , Gainesville , FL , USA.
authors.forename: Peter T
authors.initials: PT
authors.lastname: Dziegielewski
authors.affiliation: b Department of Otolaryngology , University of Florida College of Medicine , Gainesville , FL , USA.
authors.forename: Brian
authors.initials: B
authors.lastname: Boyce
authors.affiliation: a Department of Radiation Oncology , University of Florida College of Medicine , Gainesville , FL , USA.
authors.forename: William M
authors.initials: WM
authors.lastname: Mendenhall
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality / Q000532:radiotherapy* / Q000601:surgery; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy / Q000379:methods*; D009364:Neoplasm Recurrence, Local / Q000401:mortality; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D012468:Salivary Gland Neoplasms / Q000401:mortality / Q000532:radiotherapy* / Q000601:surgery; D015996:Survival Rate; D016896:Treatment Outcome; D055815:Young Adult