title: Measurements of the driving forces of bio-motors using the fluctuation theorem.
abstract: The fluctuation theorem (FT), which is a recent achievement in non-equilibrium statistical mechanics, has been suggested to be useful for measuring the driving forces of motor proteins. As an example of this application, we performed single-molecule experiments on F1-ATPase, which is a rotary motor protein, in which we measured its rotary torque by taking advantage of FT. Because fluctuation is inherent nature in biological small systems and because FT is a non-destructive force measurement method using fluctuation, it will be applied to a wide range of biological small systems in future.
authors.affiliation: Department of Applied Physics, School of Engineering, Tohoku University, Katahira, Aoba-ku, Miyagi 980-8577, Japan.
authors.forename: Kumiko
authors.initials: K
authors.lastname: Hayashi
authors.affiliation: School of Frontier Bioscience, Osaka University, Yamadaoka, Suita, Osaka 565-0871, Japan; Department of Applied Chemistry, School of Engineering, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
authors.forename: Mizue
authors.initials: M
authors.lastname: Tanigawara
authors.affiliation: Department of Molecular Biosciences, Faculty of Life Sciences, Kyoto Sangyo University, Motoyama, Kamigamo, Kita-ku, Kyoto 603-8555, Japan.
authors.forename: Jun-Ichi
authors.initials: JI
authors.lastname: Kishikawa
keywords: fluctuation; motor protein; non-equilibrium statistical mechanics