title: Genetics of Pancreatic Cancer and Its Implications on Therapy.
abstract: Over the past decade, emerging technologies have provided new insights into the genomic landscape of pancreatic ductal adenocarcinoma (PDA). In addition to the commonly recognized genetic drivers of pancreatic carcinogenesis (KRAS, CDKN2A, TP53, SMAD4), new genes and pathways have been implicated. However, these efforts have not identified any new high-frequency actionable mutations, limiting the success of mutation-targeted therapy in PDA. This article provides a report on the current landscape of pancreas cancer genetics and targeted therapeutics.
authors.affiliation: Department of Surgery, The Jefferson Pancreas, Biliary and Related Cancer Center, Sidney Kimmel Medical College, Thomas Jefferson University Hospital, 1015 Walnut Street, Suite 620, Philadelphia, PA 19107, USA.
authors.forename: Talar
authors.initials: T
authors.lastname: Tatarian
authors.affiliation: Department of Surgery, The Jefferson Pancreas, Biliary and Related Cancer Center, Sidney Kimmel Medical College, Thomas Jefferson University, 1025 Walnut Street, Suite 605, Philadelphia, PA 19107, USA. Electronic address: Jordan.Winter@jefferson.edu.
authors.forename: Jordan M
authors.initials: JM
authors.lastname: Winter
mesh_terms: D003131:Combined Modality Therapy; D019468:Disease Management; D052138:Genes, Neoplasm / Q000235:genetics*; D006801:Humans; D010190:Pancreatic Neoplasms / Q000235:genetics* / Q000628:therapy*
keywords: Genetics; Pancreatic cancer; Personalized medicine; Targeted therapy