title: Renal Artery Vasodilation May Be An Indicator of Successful Sympathetic Nerve Damage During Renal Denervation Procedure.
abstract: Autonomic nervous system plays a crucial role in maintaining and regulating vessel tension. Renal denervation (RDN) may induce renal artery vasodilation by damaging renal sympathetic fibers. We conducted this animal study to evaluate whether renal artery vasodilation could be a direct indicator of successful RDN. Twenty-eight Chinese Kunming dogs were randomly assigned into three groups and underwent RDN utilizing temperature-controlled catheter (group A, n = 11) or saline-irrigated catheter (group B, n = 11) or sham procedure (group C, n = 6). Renal angiography, blood pressure (BP) and renal artery vasodilation measurements were performed at baseline, 30-minute, 1-month, and 3-month after interventions. Plasma norepinephrine concentrations were tested at baseline and 3-month after intervention. Results showed that, in addition to significant BP reduction, RDN induced significant renal artery vasodilation. Correlation analyses showed that the induced renal artery vasodilation positively correlated with SBP reduction and plasma norepinephrine reduction over 3 months after ablation. Post hoc analyses showed that saline-irrigated catheter was superior to TC catheter in renal artery vasodilation, especially for the acute dilatation of renal artery at 30-minute after RDN. In conclusion, renal artery vasodilation, induced by RDN, may be a possible indicator of successful renal nerve damage and a predictor of blood pressure response to RDN.
authors.affiliation: Department of Cardiology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing Cardiac Arrhythmias Therapeutic Service Center, Chongqing, China.
authors.forename: Weijie
authors.initials: W
authors.lastname: Chen
authors.affiliation: Department of Cardiology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing Cardiac Arrhythmias Therapeutic Service Center, Chongqing, China.
authors.forename: Huaan
authors.initials: H
authors.lastname: Du
authors.affiliation: Department of Cardiology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing Cardiac Arrhythmias Therapeutic Service Center, Chongqing, China.
authors.forename: Jiayi
authors.initials: J
authors.lastname: Lu
authors.affiliation: Department of Cardiology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing Cardiac Arrhythmias Therapeutic Service Center, Chongqing, China.
authors.forename: Zhiyu
authors.initials: Z
authors.lastname: Ling
authors.affiliation: Department of Cardiolgy, Chongqing Province Hospital of Traditional Chinese Medicine, Chongqing, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Long
authors.affiliation: Department of Cardiology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing Cardiac Arrhythmias Therapeutic Service Center, Chongqing, China.
authors.forename: Yanping
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Department of Cardiology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing Cardiac Arrhythmias Therapeutic Service Center, Chongqing, China.
authors.forename: Peilin
authors.initials: P
authors.lastname: Xiao
authors.affiliation: Department of Cardiology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing Cardiac Arrhythmias Therapeutic Service Center, Chongqing, China.
authors.forename: Laxman
authors.initials: L
authors.lastname: Gyawali
authors.affiliation: School of Life Sciences, the Chinese University of Hong Kong, Hong Kong, China.
authors.forename: Kamsang
authors.initials: K
authors.lastname: Woo
authors.affiliation: Department of Cardiology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing Cardiac Arrhythmias Therapeutic Service Center, Chongqing, China.
authors.forename: Yuehui
authors.initials: Y
authors.lastname: Yin
authors.affiliation: Medizinische Klinik I, Krankenhaus Landshut-Achdorf, Landshut, Germany.
authors.forename: Bernhard
authors.initials: B
authors.lastname: Zrenner
mesh_terms: D000792:Angiography / Q000379:methods; D000818:Animals; D001794:Blood Pressure; D003714:Denervation / Q000379:methods*; D004285:Dogs; D007668:Kidney / Q000098:blood supply / Q000294:innervation; D009638:Norepinephrine / Q000097:blood; D011897:Random Allocation; D012077:Renal Artery / Q000000981:diagnostic imaging / Q000503:physiopathology*; D013564:Sympathetic Nervous System / Q000503:physiopathology*; D013997:Time Factors; D014664:Vasodilation
chemical_list: D009638:Norepinephrine