title: Cyclic Glucans Enhance Solubility of Bioavailable Flavonoids.
abstract: Diverse flavonoids are abundant in dietary food constituents and possess useful biological activities. However, some flavonoids have limited bioavailability due to their low solubility in water. As an important approach to enhance aqueous solubility, inclusion of hydrophobic guest molecules in hydrophilic hosts such as cyclic glucans has been used. This review summarizes applications of β-cyclodextrin, synthetic β-cyclodextrin derivatives, and newly synthesized derivatives of cyclosophoraoses as complexing agents to enhance the bioavailability of flavonoids such as baicalein, kaempferol, and naphthoflavones.
authors.affiliation: Department of Applied Chemistry, Dongduk Women's University, Seoul 136-714, Korea. sypark21@dongduk.ac.kr.
authors.forename: Seyeon
authors.initials: S
authors.lastname: Park
mesh_terms: D001682:Biological Availability; D005419:Flavonoids / Q000737:chemistry* / Q000493:pharmacokinetics*; D005936:Glucans / Q000737:chemistry*; D015394:Molecular Structure; D012995:Solubility
chemical_list: D005419:Flavonoids; D005936:Glucans
keywords: bioavailability; cyclosophoraoses; flavonoid; inclusion complex; β-cyclodextrin