title: Inhibition of breast cancer metastasis by paclitaxel-loaded pH responsive poly(β-amino ester) copolymer micelles.
abstract: OBJECTIVE
  Tumor metastasis is one of the leading causes of insufficient chemotherapy during cancer treatment. In this study, a poly(β-amino ester) derivate was developed to fabricate paclitaxel (PTX) entrapped pH-responsive copolymer micelles for inhibition of breast cancer metastasis.
  
  
  METHODS
  PTX-loaded micelles were fabricated by thin film hydration method. The inhibition efficacy of the as-prepared micelles was evaluated on MDA-MB-231 cells and tumor bearing mice.
  
  
  RESULTS
  PTX-loaded micelles were successfully prepared. Such micelles could promote drug uptake and MDA-MB-231 cell deaths, and suppress tumor metastasis.
  
  
  CONCLUSIONS
  The pH-responsive PTX-loaded micelles are promising candidates in developing stimuli triggered drug delivery systems in acidic tumor microenvironments with improved inhibitory effects on tumor metastasis.
authors.affiliation: Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Bejing 100700, China.
authors.forename: Yanjun
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Bejing 100700, China.
authors.forename: Qiaoxin
authors.initials: Q
authors.lastname: Yue
authors.affiliation: Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Bejing 100700, China.
authors.forename: Gejing
authors.initials: G
authors.lastname: De
authors.affiliation: Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Bejing 100700, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Wang
authors.affiliation: Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Bejing 100700, China.
authors.forename: Zhenzhen
authors.initials: Z
authors.lastname: Li
authors.affiliation: Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Bejing 100700, China.
authors.forename: Shuiming
authors.initials: S
authors.lastname: Xiao
authors.affiliation: Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Bejing 100700, China.
authors.forename: Huatao
authors.initials: H
authors.lastname: Yu
authors.affiliation: Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Bejing 100700, China.
authors.forename: Hai
authors.initials: H
authors.lastname: Ma
authors.affiliation: Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Bejing 100700, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Sui
authors.affiliation: Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Bejing 100700, China.
authors.forename: Qinghe
authors.initials: Q
authors.lastname: Zhao
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003374:Coumarins / Q000737:chemistry / Q000378:metabolism; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D051379:Mice; D008807:Mice, Inbred BALB C; D008823:Micelles; D017239:Paclitaxel / Q000008:administration & dosage* / Q000737:chemistry* / Q000494:pharmacology; D011108:Polymers / Q000008:administration & dosage / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D003374:Coumarins; D004337:Drug Carriers; D008823:Micelles; D011108:Polymers; C507253:poly(beta-amino ester); D017239:Paclitaxel
keywords: anticancer; invasion; metastasis; migration; paclitaxel; poly(β-amino ester)