title: Randomized Prospective Double-Blind Studies to Evaluate the Cognitive Effects of Inositol-Stabilized Arginine Silicate in Healthy Physically Active Adults.
abstract: Inositol-stabilized arginine silicate (ASI; Nitrosigine®) has been validated to increase levels of arginine, silicon and nitric oxide production. To evaluate potential enhancement of mental focus and clarity, ASI (1500 mg/day) was tested in two double-blind placebo-controlled crossover (DBPC-X) studies using the Trail Making Test (TMT, Parts A and B). In the two studies, healthy males took ASI for 14 and 3 days, respectively. In the first study, after 14 days of dosing, TMT B time decreased significantly from baseline (28% improvement,p= 0.045). In the second study evaluating shorter-term effects, TMT B time decreased significantly compared to placebo (33% improvement,p= 0.024) in a 10-min period. After 3 days of dosing, TMT B time significantly decreased from baseline scores (35% improvement,p< 0.001). These findings show that ASI significantly improved the ability to perform complex cognitive tests requiring mental flexibility, processing speed and executive functioning.
authors.affiliation: QPS-Miami Research Associates, Miller School of Medicine, University of Miami, Miami, FL 33136, USA. douglas.kalman@qps.com.
authors.forename: Douglas
authors.initials: D
authors.lastname: Kalman
authors.affiliation: Miller School of Medicine, University of Miami, Miami, FL 33143, USA. pharvey@med.miami.edu.
authors.forename: Philip D
authors.initials: PD
authors.lastname: Harvey
authors.affiliation: Nutrition 21 LLC, JDS Therapeutics LLC, 1 Manhattanville Rd., Purchase, NY 10577, USA. sperezojalvo@nutrition21.com.
authors.forename: Sara
authors.initials: S
authors.lastname: Perez Ojalvo
authors.affiliation: Nutrition 21 LLC, JDS Therapeutics LLC, 1 Manhattanville Rd., Purchase, NY 10577, USA. jkomorowski@nutrition21.com.
authors.forename: James
authors.initials: J
authors.lastname: Komorowski
mesh_terms: D000328:Adult; D001120:Arginine / Q000008:administration & dosage* / Q000031:analogs & derivatives; D001288:Attention / Q000187:drug effects; D003071:Cognition / Q000187:drug effects*; D004311:Double-Blind Method; D004338:Drug Combinations; D056344:Executive Function / Q000187:drug effects; D015444:Exercise; D000070497:Healthy Lifestyle; D006801:Humans; D007294:Inositol / Q000008:administration & dosage*; D008297:Male; D018697:Nootropic Agents / Q000008:administration & dosage*; D011446:Prospective Studies; D017640:Silicates / Q000008:administration & dosage*; D013997:Time Factors; D014145:Trail Making Test; D055815:Young Adult
chemical_list: D004338:Drug Combinations; D018697:Nootropic Agents; D017640:Silicates; C000617113:nitrosigine; D007294:Inositol; D001120:Arginine
keywords: ">l-arginine; cognitive function; mental flexibility; nitric oxide; silicate