title: Successful management of super-refractory status epilepticus with thalamic deep brain stimulation.
abstract: Super-refractory status epilepticus is a condition characterized by recurrence of status epilepticus despite use of deep general anesthesia, and it has high morbidity and mortality rates. We report a case of a 17-year-old boy with a prolonged super-refractory status epilepticus that eventually resolved after commencing deep brain stimulation of the centromedian nucleus of the thalamus. Later attempt to reduce stimulation parameters resulted in immediate relapse of status epilepticus, suggesting a pivotal role of deep brain stimulation in the treatment response. Deep brain stimulation may be a treatment option in super-refractory status epilepticus when other treatment options have failed. ANN NEUROL 2017;81:142-146.
authors.affiliation: Department of Neurosciences and Rehabilitation, Tampere University Hospital, Tampere, Finland.
authors.forename: Kai
authors.initials: K
authors.lastname: Lehtimäki
authors.affiliation: Intensive Care Unit, Tampere University Hospital, Tampere, Finland.
authors.forename: Jaakko W
authors.initials: JW
authors.lastname: Långsjö
authors.affiliation: Department of Neurosciences and Rehabilitation, Tampere University Hospital, Tampere, Finland.
authors.forename: Jyrki
authors.initials: J
authors.lastname: Ollikainen
authors.affiliation: Department of Clinical Neurophysiology, Tampere University Hospital, Tampere, Finland.
authors.forename: Hanna
authors.initials: H
authors.lastname: Heinonen
authors.affiliation: Department of Neurosciences and Rehabilitation, Tampere University Hospital, Tampere, Finland.
authors.forename: Timo
authors.initials: T
authors.lastname: Möttönen
authors.affiliation: Department of Neurosciences and Rehabilitation, Tampere University Hospital, Tampere, Finland.
authors.forename: Timo
authors.initials: T
authors.lastname: Tähtinen
authors.affiliation: Department of Neurosciences and Rehabilitation, Tampere University Hospital, Tampere, Finland.
authors.forename: Joonas
authors.initials: J
authors.lastname: Haapasalo
authors.affiliation: Intensive Care Unit, Uppsala University Hospital, Uppsala, Sweden.
authors.forename: Jyrki
authors.initials: J
authors.lastname: Tenhunen
authors.affiliation: Department of Neurosurgery, Oulu University Hospital, Oulu, Finland.
authors.forename: Jani
authors.initials: J
authors.lastname: Katisko
authors.affiliation: Department of Neurosciences and Rehabilitation, Tampere University Hospital, Tampere, Finland.
authors.forename: Juha
authors.initials: J
authors.lastname: Öhman
authors.affiliation: Department of Neurosciences and Rehabilitation, Tampere University Hospital, Tampere, Finland.
authors.forename: Jukka
authors.initials: J
authors.lastname: Peltola
mesh_terms: D000293:Adolescent; D046690:Deep Brain Stimulation; D004567:Electrodes, Implanted; D006801:Humans; D008297:Male; D013226:Status Epilepticus / Q000628:therapy*; D013788:Thalamus / Q000502:physiology*