title: In Vitro Susceptibility Testing of Bedaquiline against Mycobacterium avium Complex.
abstract: We performed bedaquiline broth microdilution susceptibility testing using Clinical and Laboratory Standards Institute (CLSI) guidelines on 103 respiratory isolates of Mycobacterium avium complex (MAC), including multidrug-resistant isolates. Approximately 90% of isolates had bedaquiline MICs of ≤0.008 μg/ml, and 102/103 isolates had MICs of ≤0.015 μg/ml. Bedaquiline has excellent potential for use in patients with MAC infections, although for reasons of its metabolism by the cytochrome P450 system, it should not be given with rifampin.
authors.affiliation: Mycobacteria/Nocardia Research Laboratory, Department of Microbiology, The University of Texas Health Science Center at Tyler, Tyler, Texas, USA barbara.elliott@uthct.edu.
authors.forename: Barbara A
authors.initials: BA
authors.lastname: Brown-Elliott
authors.affiliation: Department of Medicine, The University of Texas Health Science Center at Tyler, Tyler, Texas, USA.
authors.forename: Julie V
authors.initials: JV
authors.lastname: Philley
authors.affiliation: Department of Medicine, The University of Texas Health Science Center at Tyler, Tyler, Texas, USA.
authors.forename: David E
authors.initials: DE
authors.lastname: Griffith
authors.affiliation: Department of Medicine, The University of Texas Health Science Center at Tyler, Tyler, Texas, USA.
authors.forename: Foram
authors.initials: F
authors.lastname: Thakkar
authors.affiliation: Mycobacteria/Nocardia Research Laboratory, Department of Microbiology, The University of Texas Health Science Center at Tyler, Tyler, Texas, USA.|Department of Medicine, The University of Texas Health Science Center at Tyler, Tyler, Texas, USA.
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Wallace
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D064687:Diarylquinolines / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D015269:Mycobacterium avium Complex / Q000187:drug effects* / Q000302:isolation & purification; D015270:Mycobacterium avium-intracellulare Infection / Q000188:drug therapy / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents; D064687:Diarylquinolines; C493870:bedaquiline
keywords: Mycobacterium avium complex; bedaquiline; nontuberculous mycobacteria; susceptibility testing