title: Significance of TRP channels in oxidative stress.
abstract: Reactive oxygen species induce oxidative stress, leading to cell damage, but also function as signal transduction molecules. Transient receptor potential (TRP) channels have been attracting increasing attention as Ca2+-permeable channels that sense environmental changes. The members of one class of TRP channels have emerged as reactive oxygen species sensors. The significance of Ca2+signaling induced by the activation of reactive oxygen species-sensitive TRP channels under pathological conditions is currently being elucidated. The selective inhibition of reactive oxygen species-sensitive TRP channels represents a future challenge that may lead to new therapeutic strategies for the suppression of reactive oxygen species-related diseases.
authors.affiliation: Division of Pharmacology, Faculty of Pharmaceutical Sciences, Teikyo Heisei University, Tokyo, Japan.
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Yamamoto
authors.affiliation: Division of Pharmacology, Faculty of Pharmaceutical Sciences, Teikyo Heisei University, Tokyo, Japan. Electronic address: s.shimizu@thu.ac.jp.
authors.forename: Shunichi
authors.initials: S
authors.lastname: Shimizu
mesh_terms: D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism; D050051:Transient Receptor Potential Channels / Q000378:metabolism*
chemical_list: D017382:Reactive Oxygen Species; D050051:Transient Receptor Potential Channels
keywords: Oxidative stress; Reactive oxygen species; TRP channels; TRPA1; TRPM2