title: A pilot study to assess relationship between total IgE and 95% predictive decision points of food specific IgE concentration.
abstract: BACKGROUND
  False positive test results in children who are tested for food allergies may lead to inappropriate dietary restrictions.
  
  
  OBJECTIVE
  The aim of this study was to report our experience with a 3 year-old boy, who presented with "multiple food allergies" and, however, passed the food challenges, and to review our experience regarding management of children with high specific food IgEs with high total IgE.
  
  
  METHODS
  Medical records of 16 children with food challenges were reviewed. Median age of subjects was 39 months, with a history of adverse clinical reaction to a food, a specific IgE greater than the decision point, and an elevated total serum IgE level of 500 IU, underwent challenges to the offending food.
  
  
  RESULTS
  13 out of 16 subjects were successfully re-exposed to the suspected foods and continued to tolerate these foods well.
  
  
  CONCLUSIONS
  Our finding suggests a much lower clinical risk with previously defined specific IgE decision points in children with very high levels of total IgE (> 6000 IU/ml).
authors.affiliation: Nemours, Children's Specialty Care, Jacksonville, Florida, USA. E-mail: Eyousef@nemours.org.
authors.forename: E
authors.initials: E
authors.lastname: Yousef
authors.affiliation: VA Health Care Center, Charlotte, North Carolina, USA.
authors.forename: A S
authors.initials: AS
authors.lastname: Haque
mesh_terms: D002648:Child; D002675:Child, Preschool; D005260:Female; D005512:Food Hypersensitivity / Q000097:blood / Q000175:diagnosis* / Q000276:immunology*; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood*; D007159:Immunologic Tests / Q000379:methods / Q000592:standards*; D007223:Infant; D008297:Male; D010865:Pilot Projects; D011237:Predictive Value of Tests; D012016:Reference Values
chemical_list: D007073:Immunoglobulin E
keywords: IgE; food allergy