title: Molecular pathway activation features of pediatric acute myeloid leukemia (AML) and acute lymphoblast leukemia (ALL) cells.
abstract: Acute lymphoblast leukemia (ALL) is characterized by overproduction of immature white blood cells in the bone marrow. ALL is most common in the childhood and has high (>80%) cure rate. In contrast, acute myeloid leukemia (AML) has far greater mortality rate than the ALL and is most commonly affecting older adults. However, AML is a leading cause of childhood cancer mortality. In this study, we compare gene expression and molecular pathway activation patterns in three normal blood, seven pediatric ALL and seven pediatric AML bone marrow samples. We identified 172/94 and 148/31 characteristic gene expression/pathway activation signatures, clearly distinguishingpediatricALL and AML cells, respectively, from the normal blood. ThepediatricAML and ALL cells differed by 139/34 gene expression/pathway activation biomarkers. For theadult30 AML and 17 normal blood samples, we found 132/33 gene expression/pathway AML-specific features, of which only 7/2 were common for the adult and pediatric AML and, therefore, age-independent. At the pathway level, we found more differences than similarities between the adult and pediatric forms. These findings suggest that the adult and pediatric AMLs may require different treatment strategies.
authors.affiliation: D. Rogachev Federal Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, 117198, Russia.|First Oncology Research and Advisory Center, Moscow, 117997, Russia.|Moscow Institute of Physics and Technology, Dolgoprudny, Moscow region, 141700, Russia.
authors.forename: Ivan
authors.initials: I
authors.lastname: Petrov
authors.affiliation: D. Rogachev Federal Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, 117198, Russia.|Group for Genomic Regulation of Cell Signaling Systems, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, 117997, Russia.
authors.forename: Maria
authors.initials: M
authors.lastname: Suntsova
authors.affiliation: D. Rogachev Federal Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, 117198, Russia.|Morozov Pediatric Clinical Hospital, Moscow, 101000, Russia.
authors.forename: Olga
authors.initials: O
authors.lastname: Mutorova
authors.affiliation: National Research Centre "Kurchatov Institute", Centre for Convergence of Nano-, Bio-, Information and Cognitive Sciences and Technologies, Moscow, 123182, Russia.|Pathway Pharmaceuticals, Wan Chai, Hong Kong, Hong Kong SAR.
authors.forename: Maxim
authors.initials: M
authors.lastname: Sorokin
authors.affiliation: D. Rogachev Federal Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, 117198, Russia.|Moscow Institute of Physics and Technology, Dolgoprudny, Moscow region, 141700, Russia.
authors.forename: Andrew
authors.initials: A
authors.lastname: Garazha
authors.affiliation: First Oncology Research and Advisory Center, Moscow, 117997, Russia.
authors.forename: Elena
authors.initials: E
authors.lastname: Ilnitskaya
authors.affiliation: Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Mosow, Russia,119991.
authors.forename: Pavel
authors.initials: P
authors.lastname: Spirin
authors.affiliation: D. Rogachev Federal Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, 117198, Russia.
authors.forename: Sergey
authors.initials: S
authors.lastname: Larin
authors.affiliation: Department of Biological Sciences, University of Lethbridge, Lethbridge, AB, T1K3M4, Canada.
authors.forename: Olga
authors.initials: O
authors.lastname: Kovalchuk
authors.affiliation: Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Mosow, Russia,119991.
authors.forename: Vladimir
authors.initials: V
authors.lastname: Prassolov
authors.affiliation: D. Rogachev Federal Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, 117198, Russia.|First Oncology Research and Advisory Center, Moscow, 117997, Russia.
authors.forename: Alex
authors.initials: A
authors.lastname: Zhavoronkov
authors.affiliation: D. Rogachev Federal Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, 117198, Russia.
authors.forename: Alexander
authors.initials: A
authors.lastname: Roumiantsev
authors.affiliation: D. Rogachev Federal Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, 117198, Russia.|Group for Genomic Regulation of Cell Signaling Systems, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, 117997, Russia.|National Research Centre "Kurchatov Institute", Centre for Convergence of Nano-, Bio-, Information and Cognitive Sciences and Technologies, Moscow, 123182, Russia.
authors.forename: Anton
authors.initials: A
authors.lastname: Buzdin
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D014408:Biomarkers, Tumor; D001853:Bone Marrow; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D015870:Gene Expression; D020869:Gene Expression Profiling; D006801:Humans; D007223:Infant; D015470:Leukemia, Myeloid, Acute / Q000097:blood / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood / Q000235:genetics* / Q000401:mortality / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor
keywords: OncoFinder; acute lymphoblast leukemia; acute myeloid leukemia; adult; gene expression; intracellular signaling pathways; molecular markers; pediatric