title: The effects of magnesium supplementation on subjective anxiety.
abstract: Experimental studies of anxiety in animal models, and evidence of efficacious outcomes of magnesium (Mg) supplementation in the treatment of acute clinical affective disorders, has increased interest in Mg as a potential novel treatment for symptoms of mild/moderate subjective anxiety. This short review examines the existing evidence for the effects of Mg supplementation on subjective anxiety in humans. Additionally, evidence from three unpublished studies that examined Mg and vitamin B6intake on subjective anxiety is summarised to supplement the existing literature.
  
  
  CONCLUSIONS
  The efficacy of Mg in the treatment of anxiety in the mildly anxious and those reporting premenstrual syndrome-related anxiety is suggestive of a beneficial effect of Mg intake. Further randomised controlled trials are warranted to further establish the efficacy of Mg as a novel treatment for subjective anxiety.
authors.affiliation: School of Psychology, University of Leeds, Leeds, LS2 9JT, UK.
authors.forename: Neil Bernard
authors.initials: NB
authors.lastname: Boyle
authors.affiliation: School of Psychology, University of Leeds, Leeds, LS2 9JT, UK.
authors.forename: Clare L
authors.initials: CL
authors.lastname: Lawton
authors.affiliation: School of Psychology, University of Leeds, Leeds, LS2 9JT, UK.
authors.forename: Louise
authors.initials: L
authors.lastname: Dye
mesh_terms: D000818:Animals; D001007:Anxiety / Q000178:diet therapy*; D019587:Dietary Supplements; D006801:Humans; D008274:Magnesium / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D008274:Magnesium
keywords: human; magnesium; subjective anxiety; supplementation