title: Prostatic urethral lift vs transurethral resection of the prostate: 2-year results of the BPH6 prospective, multicentre, randomized study.
abstract: To compare prostatic urethral lift (PUL) with transurethral resection of the prostate (TURP) with regard to symptoms, recovery experience, sexual function, continence, safety, quality of life, sleep and overall patient perception.
  
  
  
  A total of 80 patients with lower urinary tract symptoms attributable to benign prostatic hyperplasia (BPH) were enrolled in a prospective, randomized, controlled, non-blinded study conducted at 10 European centres. The BPH6 responder endpoint assessed symptom relief, quality of recovery, erectile function preservation, ejaculatory function preservation, continence preservation and safety. Additional evaluations of patient perspective, quality of life and sleep were prospectively collected, analysed and presented for the first time.
  
  
  
  Significant improvements in International Prostate Symptom Score (IPSS), IPSS quality of life (QoL), BPH Impact Index (BPHII), and maximum urinary flow rate (Qmax) were observed in both arms throughout the 2-year follow up. Change in IPSS and Qmaxin the TURP arm were superior to the PUL arm. Improvements in IPSS QoL and BPHII score were not statistically different between the study arms. PUL resulted in superior quality of recovery, ejaculatory function preservation and performance on the composite BPH6 index. Ejaculatory function bother scores did not change significantly in either treatment arm. TURP significantly compromised continence function at 2 weeks and 3 months. Only PUL resulted in statistically significant improvement in sleep.
  
  
  
  PUL was compared to TURP in a randomised, controlled study which further characterized both modalities so that care providers and patients can better understand the net benefit when selecting a treatment option.
authors.affiliation: Department of Urology, Ludwig-Maximilians University, Munich, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Gratzke
authors.affiliation: Frimley Park Hospital NHS Foundation Trust, Surrey, UK.
authors.forename: Neil
authors.initials: N
authors.lastname: Barber
authors.affiliation: Department of Urology, Taunton and Somerset NHS Trust, Taunton, UK.
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Speakman
authors.affiliation: PAN Klinik Köln, Köln, Germany.
authors.forename: Richard
authors.initials: R
authors.lastname: Berges
authors.affiliation: Department of Urology, University Hospital Freiburg, Freiburg, Germany.
authors.forename: Ulrich
authors.initials: U
authors.lastname: Wetterauer
authors.affiliation: City Hospitals Sunderland, Sunderland, UK.
authors.forename: Damien
authors.initials: D
authors.lastname: Greene
authors.affiliation: University Clinic of Lübeck, Lübeck, Germany.
authors.forename: Karl-Dietrich
authors.initials: KD
authors.lastname: Sievert
authors.affiliation: Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
authors.forename: Christopher R
authors.initials: CR
authors.lastname: Chapple
authors.affiliation: Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
authors.forename: Jacob M
authors.initials: JM
authors.lastname: Patterson
authors.affiliation: Department of Urology, Herlev Hospital, Herlev, Denmark.
authors.forename: Lasse
authors.initials: L
authors.lastname: Fahrenkrug
authors.affiliation: Department of Urology, University Hospital Freiburg, Freiburg, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Schoenthaler
authors.affiliation: Department of Urology, Herlev Hospital, Herlev, Denmark.
authors.forename: Jens
authors.initials: J
authors.lastname: Sonksen
mesh_terms: D004542:Ejaculation; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011467:Prostate / Q000601:surgery*; D011470:Prostatic Hyperplasia / Q000601:surgery*; D013997:Time Factors; D020728:Transurethral Resection of Prostate; D014521:Urethra / Q000601:surgery*
keywords: #UroBPH; BPH; LUTS; UroLift; prostatic urethral lift; sexual function