title: Exosomes in Tumor Angiogenesis.
abstract: Exosomes are small vesicles ranging in size between 30 and 150 nm, derived from the luminal membranes of the endosome and are constitutively released by fusion with the cell membrane. Several studies have revealed that exosomes play crucial roles in mediating local and systemic cell communication through the horizontal transfer of information in the form of nucleic material and proteins. This is particularly relevant in the context of the tumor-microenvironment cross talk. Here we describe the method of isolating exosomes and their role in modifying the tumor environment and more specifically in enabling metastasis and promoting angiogenesis.
authors.affiliation: Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
authors.forename: Karma Z
authors.initials: KZ
authors.lastname: Salem
authors.affiliation: Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
authors.forename: Michele
authors.initials: M
authors.lastname: Moschetta
authors.affiliation: Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
authors.forename: Antonio
authors.initials: A
authors.lastname: Sacco
authors.affiliation: ASST Spedali Civili, Department of Medical Oncology, CREA Laboratory, Brescia, Italy.
authors.forename: Luisa
authors.initials: L
authors.lastname: Imberti
authors.affiliation: ASST Spedali Civili, Department of Medical Oncology, CREA Laboratory, Brescia, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Rossi
authors.affiliation: Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
authors.forename: Irene M
authors.initials: IM
authors.lastname: Ghobrial
authors.affiliation: Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
authors.forename: Salomon
authors.initials: S
authors.lastname: Manier
authors.affiliation: Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA. aldo_roccaro@dfci.harvard.edu.|ASST Spedali Civili, Department of Medical Oncology, CREA Laboratory, Brescia, Italy. aldo_roccaro@dfci.harvard.edu.
authors.forename: Aldo M
authors.initials: AM
authors.lastname: Roccaro
mesh_terms: D042501:Angiogenic Proteins / Q000235:genetics / Q000378:metabolism; D002450:Cell Communication; D045744:Cell Line, Tumor; D055354:Exosomes / Q000378:metabolism* / Q000502:physiology; D006801:Humans; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000098:blood supply / Q000473:pathology*; D009389:Neovascularization, Pathologic / Q000378:metabolism*; D053141:Organelle Size; D059016:Tumor Microenvironment; D014461:Ultracentrifugation; D014462:Ultrafiltration
chemical_list: D042501:Angiogenic Proteins
keywords: Angiogenesis; Cancer; Exosome; Microenvironment; Pre-metastatic niche; Tumor