title: Exclusive intraoperative radiotherapy for invasive breast cancer in elderly patients (>70 years): proportion of eligible patients and local recurrence-free survival.
abstract: BACKGROUND
  To estimate the proportion of elderly patients (>70 years) with breast cancer eligible for an Exclusive IntraOperative RadioTherapy (E-IORT) and to evaluate their local recurrence-free survival rate.
  
  
  METHODS
  This retrospective study examining two cohorts focuses on patients over 70 years old: a multi-centric cohort of 1411 elderly patients and a mono-centric cohort of 592 elderly patients. All patients underwent conservative surgery followed by external radiotherapy for T0-T3 N0-N1 invasive breast cancer, between 1980 and 2008.
  
  
  RESULTS
  Within each cohort two groups were identified according to the inclusion criteria of the RIOP trial (R group) and TARGIT E study (T group). Each group was divided into two sub-groups, patients eligible (E) or non-eligible (nE) for IORT. The population of patients that were eligible in the TARGIT E study but not in the RIOP trial were also studied in both cohorts. The proportion of patients eligible for IORT was calculated, according to the eligibility criteria of each study. A comparison of the 5-year local or locoregional recurrence-free survival rate between eligible vs non-eligible patients was made. In both cohorts, the proportion of patients eligible according to the RIOP trial's eligibility criteria was 35.4 and 19.3%, and according to the TARGIT E study criteria was 60.9 and 45.3%. The 5-year locoregional recurrence-free survival rate was not significantly different between RE and RnE groups, TE and TnE groups. In both cohorts RE and (TE-RE) groups were not significantly different.
  
  
  CONCLUSIONS
  Our results encourage further necessary studies to define and to extend the eligibility criteria for per operative exclusive radiotherapy.
authors.affiliation: Institut Paoli Calmettes, 232 Boulevard de Sainte-Marguerite, 13009, Marseille, France. lambaudiee@ipc.unicancer.fr.|CRCM, Marseille, France. lambaudiee@ipc.unicancer.fr.|Aix Marseille Université, Marseille, France. lambaudiee@ipc.unicancer.fr.
authors.forename: Eric
authors.initials: E
authors.lastname: Lambaudie
authors.affiliation: Institut Paoli Calmettes, 232 Boulevard de Sainte-Marguerite, 13009, Marseille, France.|CRCM, Marseille, France.|Aix Marseille Université, Marseille, France.
authors.forename: Gilles
authors.initials: G
authors.lastname: Houvenaeghel
authors.affiliation: Institut Paoli Calmettes, 232 Boulevard de Sainte-Marguerite, 13009, Marseille, France.|CRCM, Marseille, France.|Aix Marseille Université, Marseille, France.
authors.forename: Amira
authors.initials: A
authors.lastname: Ziouèche
authors.affiliation: Institut Paoli Calmettes, 232 Boulevard de Sainte-Marguerite, 13009, Marseille, France.|CRCM, Marseille, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Knight
authors.affiliation: Institut René Gauducheau, Nantes, France.
authors.forename: François
authors.initials: F
authors.lastname: Dravet
authors.affiliation: Institut Gustave Roussy, Villejuif, France.
authors.forename: Jean Remy
authors.initials: JR
authors.lastname: Garbay
authors.affiliation: Centre Oscar Lambret, Lille, France.
authors.forename: Sylvie
authors.initials: S
authors.lastname: Giard
authors.affiliation: Centre Claudius Regaud, Toulouse, France.
authors.forename: Hélène
authors.initials: H
authors.lastname: Charitansky
authors.affiliation: Institut Paoli Calmettes, 232 Boulevard de Sainte-Marguerite, 13009, Marseille, France.|CRCM, Marseille, France.|Aix Marseille Université, Marseille, France.
authors.forename: Monique
authors.initials: M
authors.lastname: Cohen
authors.affiliation: Centre Léon Bérard, Lyon, France.
authors.forename: Christelle
authors.initials: C
authors.lastname: Faure
authors.affiliation: Centre Georges François Leclerc, Dijon, France.
authors.forename: Delphine
authors.initials: D
authors.lastname: Hudry
authors.affiliation: Hôpital de Grasse, Grasse, France.
authors.forename: Paul
authors.initials: P
authors.lastname: Azuar
authors.affiliation: Hôpital des Diaconesses, Paris, France.
authors.forename: Richard
authors.initials: R
authors.lastname: Villet
authors.affiliation: Centre Jean Perrin, Clermont Ferrand, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Gimbergues
authors.affiliation: Institut Bergonié, Bordeaux, France.
authors.forename: Christine Tunon
authors.initials: CT
authors.lastname: de Lara
authors.affiliation: Institut Paoli Calmettes, 232 Boulevard de Sainte-Marguerite, 13009, Marseille, France.|CRCM, Marseille, France.|Aix Marseille Université, Marseille, France.
authors.forename: Agnès
authors.initials: A
authors.lastname: Tallet
authors.affiliation: Institut Paoli Calmettes, 232 Boulevard de Sainte-Marguerite, 13009, Marseille, France.|CRCM, Marseille, France.|Aix Marseille Université, Marseille, France.
authors.forename: Marie
authors.initials: M
authors.lastname: Bannier
authors.affiliation: Institut Paoli Calmettes, 232 Boulevard de Sainte-Marguerite, 13009, Marseille, France.|CRCM, Marseille, France.|Aix Marseille Université, Marseille, France.
authors.forename: Mathieu
authors.initials: M
authors.lastname: Minsat
authors.affiliation: Institut Paoli Calmettes, 232 Boulevard de Sainte-Marguerite, 13009, Marseille, France.|CRCM, Marseille, France.|Aix Marseille Université, Marseille, France.
authors.forename: Michel
authors.initials: M
authors.lastname: Resbeut
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery*; D018270:Carcinoma, Ductal, Breast / Q000401:mortality / Q000532:radiotherapy* / Q000601:surgery*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007430:Intraoperative Care; D008408:Mastectomy; D008875:Middle Aged; D018579:Patient Selection; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult
keywords: Breast cancer; Elderly patients; Intraoperative radiotherapy