title: Nondestructive Microcomputed Tomography Evaluation of Mineral Density in Exfoliated Teeth with Hypophosphatasia.
abstract: Most cases of hypophosphatasia (HPP) exhibit early loss of primary teeth. Results of microcomputed tomography (micro-CT) analysis of teeth with HPP have rarely been reported. The purpose of the present study was to describe the mineral density distribution and mapping of exfoliated teeth from an HPP patient using micro-CT. Four exfoliated teeth were obtained from a patient with HPP. Enamel and dentin mineral densities of exfoliated teeth were measured on micro-CT. The mean values of enamel and dentin mineral densities in mandibular primary central incisors with HPP were 1.61 and 0.98 g/cm3, respectively. The corresponding values in the mandibular primary lateral incisors were 1.60 and 0.98 g/cm3, respectively. Enamel hypoplasia was seen in the remaining teeth, both maxillary and mandibular primary canines and first and second molars. Micro-CT enables nondestructive, noninvasive evaluation and is useful for studying human hard tissues obtained from patients.
authors.affiliation: Division of Oral and Maxillofacial Radiology, Niigata University Graduate School of Medical and Dental Sciences, 2-5274 Gakkocho-dori, Chuo-ku, Niigata 951-8514, Japan.
authors.forename: Sachiko
authors.identifier: 0000-0002-2330-095X
authors.initials: S
authors.lastname: Hayashi-Sakai
authors.affiliation: Division of Oral and Maxillofacial Radiology, Niigata University Graduate School of Medical and Dental Sciences, 2-5274 Gakkocho-dori, Chuo-ku, Niigata 951-8514, Japan.
authors.forename: Takafumi
authors.initials: T
authors.lastname: Hayashi
authors.affiliation: Department of Health Sciences, Faculty of Medicine, Niigata University, 2-746 Asahimachi-dori, Chuo-ku, Niigata 951-8514, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Sakamoto
authors.affiliation: Department of System and Automotive Engineering, Niigata College of Technology, 5-13-7 Kamishinei-cho, Nishi-ku, Niigata 950-2076, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Sakai
authors.affiliation: Department of Pediatric Dentistry, The Nippon Dental University, School of Life Dentistry at Niigata, 1-8 Hamaura-cho, Chuo-ku, Niigata 951-8580, Japan.
authors.forename: Junko
authors.initials: J
authors.lastname: Shimomura-Kuroki
authors.affiliation: Division of Oral and Maxillofacial Radiology, Niigata University Graduate School of Medical and Dental Sciences, 2-5274 Gakkocho-dori, Chuo-ku, Niigata 951-8514, Japan.
authors.forename: Hideyoshi
authors.initials: H
authors.lastname: Nishiyama
authors.affiliation: Division of Oral and Maxillofacial Radiology, Niigata University Graduate School of Medical and Dental Sciences, 2-5274 Gakkocho-dori, Chuo-ku, Niigata 951-8514, Japan.
authors.forename: Kouji
authors.initials: K
authors.lastname: Katsura
authors.affiliation: Division of Oral and Maxillofacial Radiology, Niigata University Graduate School of Medical and Dental Sciences, 2-5274 Gakkocho-dori, Chuo-ku, Niigata 951-8514, Japan.
authors.forename: Makiko
authors.initials: M
authors.lastname: Ike
authors.affiliation: Division of Oral and Maxillofacial Radiology, Niigata University Graduate School of Medical and Dental Sciences, 2-5274 Gakkocho-dori, Chuo-ku, Niigata 951-8514, Japan.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Nikkuni
authors.affiliation: Division of Oral and Maxillofacial Radiology, Niigata University Graduate School of Medical and Dental Sciences, 2-5274 Gakkocho-dori, Chuo-ku, Niigata 951-8514, Japan.
authors.forename: Miwa
authors.initials: M
authors.lastname: Nakayama
authors.affiliation: Division of Oral and Maxillofacial Radiology, Niigata University Graduate School of Medical and Dental Sciences, 2-5274 Gakkocho-dori, Chuo-ku, Niigata 951-8514, Japan.
authors.forename: Marie
authors.initials: M
authors.lastname: Soga
authors.affiliation: Division of Oral and Maxillofacial Radiology, Niigata University Graduate School of Medical and Dental Sciences, 2-5274 Gakkocho-dori, Chuo-ku, Niigata 951-8514, Japan.
authors.forename: Taichi
authors.initials: T
authors.lastname: Kobayashi