title: Comparison of Matrigel and Matriderm as a carrier for human amnion-derived mesenchymal stem cells in wound healing.
abstract: Amnion-derived mesenchymal stem cells (AMSC) are a promising tool in regenerative medicine. Here we evaluated the utility of Matrigel and Matriderm as carrier for the topical application of AMSC to mice skin wounds. In both application forms, AMSC promoted neovascularization of the wound area. Matrigel proved as excellent matrix for AMSC and immigrating mouse cells, but the solid Matriderm enabled a more adequate positioning of AMSC into the wound. Although AMSC did not attach to Matriderm, they reliably induced wound reduction. Thus, a combined administration of AMSC/Matriderm could be beneficial to potentiate the encouraging effects on wound healing.
authors.affiliation: Research Unit for Tissue Regeneration, Repair, and Reconstruction, Division of Plastic, Aesthetic and Reconstructive Surgery, Department of Surgery, Medical University of Graz, Graz, Austria.
authors.forename: Alexandru-Cristian
authors.initials: AC
authors.lastname: Tuca
authors.affiliation: Institute of Cell Biology, Histology and Embryology, Medical University of Graz, Graz, Austria.
authors.forename: Juliane
authors.initials: J
authors.lastname: Ertl
authors.affiliation: Institute of Cell Biology, Histology and Embryology, Medical University of Graz, Graz, Austria.
authors.forename: Kerstin
authors.initials: K
authors.lastname: Hingerl
authors.affiliation: Research Unit for Tissue Regeneration, Repair, and Reconstruction, Division of Plastic, Aesthetic and Reconstructive Surgery, Department of Surgery, Medical University of Graz, Graz, Austria.
authors.forename: Melanie
authors.initials: M
authors.lastname: Pichlsberger
authors.affiliation: Research Unit for Tissue Regeneration, Repair, and Reconstruction, Division of Plastic, Aesthetic and Reconstructive Surgery, Department of Surgery, Medical University of Graz, Graz, Austria.
authors.forename: Jakob
authors.initials: J
authors.lastname: Fuchs
authors.affiliation: Research Unit for Tissue Regeneration, Repair, and Reconstruction, Division of Plastic, Aesthetic and Reconstructive Surgery, Department of Surgery, Medical University of Graz, Graz, Austria.
authors.forename: Paul
authors.initials: P
authors.lastname: Wurzer
authors.affiliation: Institute of Cell Biology, Histology and Embryology, Medical University of Graz, Graz, Austria.
authors.forename: Dagmar
authors.initials: D
authors.lastname: Pfeiffer
authors.affiliation: Division of Biomedical Research, Medical University of Graz, Graz, Austria.
authors.forename: Vladimir
authors.initials: V
authors.lastname: Bubalo
authors.affiliation: Research Unit for Tissue Regeneration, Repair, and Reconstruction, Division of Plastic, Aesthetic and Reconstructive Surgery, Department of Surgery, Medical University of Graz, Graz, Austria.
authors.forename: Daryousch
authors.initials: D
authors.lastname: Parvizi
authors.affiliation: Research Unit for Tissue Regeneration, Repair, and Reconstruction, Division of Plastic, Aesthetic and Reconstructive Surgery, Department of Surgery, Medical University of Graz, Graz, Austria.
authors.forename: Lars-Peter
authors.initials: LP
authors.lastname: Kamolz
authors.affiliation: Institute of Cell Biology, Histology and Embryology, Medical University of Graz, Graz, Austria. Electronic address: ingrid.lang@medunigraz.at.
authors.forename: Ingrid
authors.initials: I
authors.lastname: Lang
mesh_terms: D000818:Animals; D003094:Collagen / Q000627:therapeutic use*; D004338:Drug Combinations; D004549:Elastin / Q000627:therapeutic use*; D006801:Humans; D007797:Laminin / Q000627:therapeutic use*; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D051379:Mice; D018919:Neovascularization, Physiologic / Q000502:physiology*; D011509:Proteoglycans / Q000627:therapeutic use*; D014945:Wound Healing / Q000502:physiology*
chemical_list: D004338:Drug Combinations; D007797:Laminin; D011509:Proteoglycans; C532298:matriderm; C059485:matrigel; D003094:Collagen; D004549:Elastin
keywords: Amnion; Angiogenesis; Human placenta; Mesenchymal stem cells; Mouse model; Wound healing