title: Outcome differences between simple and complex gastroschisis.
abstract: BACKGROUND
  We reviewed differences of the outcome of newborn with simple and complex gastroschisis treated at our institution over the past fifteen years.
  
  
  METHODS
  A retrospective cohort study was performed on all infants with gastroschisis treated at the Institute for mother and child health care, Belgrade, between 2001 and 2015 (n=70). Premature infants (<34 weeks of gestation) and babies with birth weight less than 1500 g were excluded (n=5). We compared outcomes in infants with simple gastroschisis and those with complex gastroschisis. An outcome analysis was performed for birth weight, gestational age, gender, mode of defect closure, presence of intestinal necrosis or perforation, reoperation, duration of mechanical ventilation and total parenteral nutrition, presence of bowel pseudoopstraction, sepsis, total duration of hospital stay, mortality rates.
  
  
  RESULTS
  Of 65 patients, 15 (23,07%) had complex gastroschisis, including atresia 5 patients (33,3%), ischemic complication 9 patients (60%) and one patient with closing gastroschisis (6,66%). Sixty eight percent underwent primary closure.There was difference between the simple and the complex gastroschisis in duration of mechanical ventilation (P= ,000003), total parenteral nutrition (P= ,000019), bowel pseudoobstruction (P= ,00067), reoperation (P= ,00122), sepsis (P= ,0043), hospital stay (P= ,000198). In the simple gastroschisis group 92% of patients survived to discharge. In the complex gastroschisis group 3 patients died in hospital (P= ,338).
  
  
  CONCLUSIONS
  More research should be focused to predict complex gastroschisis and to improve prenatal diagnosis and postnatal management, without a significant increase in morbidity and mortality.
  
  
  BACKGROUND
  Complex, Gastroschisis, Outcomes, Simple, Vanishing.
authors.forename: Vesna Milojkovic
authors.initials: VM
authors.lastname: Marinovic
authors.forename: Maija
authors.initials: M
authors.lastname: Lukac
authors.forename: Zeljko
authors.initials: Z
authors.lastname: Mikovic
authors.forename: Blagoje
authors.initials: B
authors.lastname: Grujic
authors.forename: Maja
authors.initials: M
authors.lastname: Milickovic
authors.forename: Gordana
authors.initials: G
authors.lastname: Samardžija
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Stojanovic
authors.forename: Dalibor
authors.initials: D
authors.lastname: Sabbagh
mesh_terms: D015331:Cohort Studies; D005260:Female; D020139:Gastroschisis / Q000145:classification* / Q000601:surgery*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D012189:Retrospective Studies; D016896:Treatment Outcome