title: Alterations in nasal mucociliary activity in polycystic ovary syndrome.
abstract: OBJECTIVE
  Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age. It can affect various organ systems, and respiratory mucosa has been reported as being hormone responsive.
  
  
  METHODS
  A case-control study consisting of 50 women with PCOS and 30 control subjects matched for age and body mass index was conducted, in order to investigate nasal mucociliary clearance time (NMCT) in patients with PCOS. Serum basal hormonal-biochemical parameters and NMCT were evaluated on menstrual cycle days 2-5 for all participants.
  
  
  RESULTS
  The mean NMCT in PCOS and control groups was 10.45±2.88 and 6.92±1.78, respectively (p=0.0001). A significant positive correlation was found between NMCT and duration of disease (r=0.52; p=0.001), serum total testosterone level (r=0.28; p=0.04), and luteinizing hormone/follicle stimulating hormone (r=0.29; p=0.04).
  
  
  CONCLUSIONS
  Our findings indicate that PCOS is associated with altered NMCT. Prolonged NMCT predisposes patients to respiratory tract and middle ear infections, and clinicians should be aware of this.
authors.affiliation: Dumlupinar University Medical Faculty, Evliya Celebi Training and Research Hospital, Department of Obstetrics and Gynecology, Okmeydani Street Evliya Celebi Avenue 43000, Kutahya, Turkey. Electronic address: dr.suna@hotmail.com.
authors.forename: Suna
authors.initials: S
authors.lastname: Kabil Kucur
authors.affiliation: Dumlupinar University Medical Faculty, Evliya Celebi Training and Research Hospital, Department of Obstetrics and Gynecology, Okmeydani Street Evliya Celebi Avenue 43000, Kutahya, Turkey. Electronic address: draliseven@hotmail.com.
authors.forename: Ali
authors.initials: A
authors.lastname: Seven
authors.affiliation: Dumlupinar University Medical Faculty, Evliya Celebi Training and Research Hospital, Department of Obstetrics and Gynecology, Okmeydani Street Evliya Celebi Avenue 43000, Kutahya, Turkey. Electronic address: berilyuksel@gmail.com.
authors.forename: Beril
authors.initials: B
authors.lastname: Yuksel
authors.affiliation: Dumlupinar University Medical Faculty, Evliya Celebi Training and Research Hospital, Department of Otolaryngology Head and Neck Surgery, Okmeydani Street Evliya Celebi Avenue, Kutahya 43000, Turkey. Electronic address: ckucurl@gmail.com.
authors.forename: Cuneyt
authors.initials: C
authors.lastname: Kucur
authors.affiliation: Dumlupinar University Medical Faculty, Evliya Celebi Training and Research Hospital, Department of Obstetrics and Gynecology, Okmeydani Street Evliya Celebi Avenue 43000, Kutahya, Turkey. Electronic address: drhalimesencan@gmail.com.
authors.forename: Halime
authors.initials: H
authors.lastname: Sencan
authors.affiliation: Mustafa Kemal University Medical Faculty, Department of Obstetrics and Gynecology, Turkey. Electronic address: ilayozt@gmail.com.
authors.forename: Ilay
authors.initials: I
authors.lastname: Gozukara
authors.affiliation: Dumlupinar University Medical Faculty, Evliya Celebi Training and Research Hospital, Department of Obstetrics and Gynecology, Okmeydani Street Evliya Celebi Avenue 43000, Kutahya, Turkey. Electronic address: nadikeskin@gmail.com.
authors.forename: Nadi
authors.initials: N
authors.lastname: Keskin
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002923:Cilia / Q000378:metabolism*; D015536:Down-Regulation; D005260:Female; D043373:Follicle Stimulating Hormone, Human / Q000097:blood; D006801:Humans; D017588:Hyperandrogenism / Q000209:etiology; D007986:Luteinizing Hormone / Q000097:blood; D009079:Mucociliary Clearance; D009297:Nasal Mucosa / Q000503:physiopathology*; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000503:physiopathology*; D015203:Reproducibility of Results; D013739:Testosterone / Q000097:blood; D014421:Turkey; D055815:Young Adult
chemical_list: D043373:Follicle Stimulating Hormone, Human; D013739:Testosterone; D007986:Luteinizing Hormone
keywords: Hyperandrogenism; Nasal mucociliary clearance; Nasal mucosa; Polycystic ovary syndrome