title: Arginine-Dual roles as an onconutrient and immunonutrient.
abstract: Arginine is an important player in numerous biologic processes and studies have demonstrated its importance for cellular growth that becomes limiting in states of rapid turnover (e.g., malignancy). Thus, arginine deprivation therapy is being examined as an adjuvant cancer therapy, however, arginine is also necessary for immune destruction of malignant cells. Herein we review the data supporting arginine deprivation or supplementation in cancer treatment and the currently registered trials aimed at understanding these divergent strategies. J. Surg. Oncol. 2017;115:273-280. © 2016 Wiley Periodicals, Inc.
authors.affiliation: Division of General Surgery, Department of Surgery, Vanderbilt University School of Medicine, Nashville, Tennessee.
authors.forename: Vance L
authors.initials: VL
authors.lastname: Albaugh
authors.affiliation: Division of General Surgery, Department of Surgery, Vanderbilt University School of Medicine, Nashville, Tennessee.
authors.forename: Carolina
authors.initials: C
authors.lastname: Pinzon-Guzman
authors.affiliation: Division of General Surgery, Department of Surgery, Vanderbilt University School of Medicine, Nashville, Tennessee.
authors.forename: Adrian
authors.initials: A
authors.lastname: Barbul
mesh_terms: D000818:Animals; D001120:Arginine / Q000008:administration & dosage* / Q000172:deficiency* / Q000276:immunology / Q000378:metabolism; D019587:Dietary Supplements; D006801:Humans; D009369:Neoplasms / Q000276:immunology / Q000378:metabolism / Q000628:therapy*
chemical_list: D001120:Arginine
keywords: Warburg effect; immunonutrition; metabolism; nutritional oncology