title: [Feature of magnetic resonance imaging in patients with Creutzfeldt-Jakob disease].
abstract: Objective:To assess the imaging features of 43 patients diagnosed as clinically possible or probable Creutzfeldt-Jakob disease (CJD) for providing referential information and experience on applications of MRI in the clinical diagnosis and treatment of CJD.Method:All patients who were diagnosed with "suspected CJD" and hospitalized in Xuanwu Hospital from January 2013 to November 2015 were collected, and their clinical information and MRI imaging features were analyzed retrospectively.Results:Totally 62 patients with "suspected CJD" were rectruited in this study, and 43 of them were diagnosied as probable and possible CJD when they were discharged.The typical MRI feature of CJD patients was "cortical ribbon" sign in MR DWI sequences and/or high signal in cortex or bilateral basal ganglia.In all patients, the simple coritcal involvement was the highest(76.47%, 26/34), followed by the cortical cortex and basal ganglia(23.53%, 8/34). MRI positive group had more prominent extrapyramidal symptoms than MRI negative group (26/31 vs 9/12,P=0.015), but no statistical difference in clinic feature was found between the group with simple cortex affected and the group with both cortex and bilateral basal ganglia affected (P>0.05).Conclusions:MRI images of patients with CJD have special characteristics and have corresponding changes when the patients are in different stages of disease. In combination with the clinical evaluation of disease progression, brain microscopic pathological changes of CJD patients can be assessed by regularly brain MRI examination.
authors.affiliation: Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.
authors.forename: H X
authors.initials: HX
authors.lastname: Wang
authors.forename: J
authors.initials: J
authors.lastname: Liu
authors.forename: Y H
authors.initials: YH
authors.lastname: Yang
authors.forename: H P
authors.initials: HP
authors.lastname: Sun
authors.forename: A H
authors.initials: AH
authors.lastname: Liu
authors.forename: L P
authors.initials: LP
authors.lastname: Li
authors.forename: J
authors.initials: J
authors.lastname: Ye
authors.forename: Y
authors.initials: Y
authors.lastname: Hou
authors.forename: Y
authors.initials: Y
authors.lastname: Sun
authors.forename: H Q
authors.initials: HQ
authors.lastname: Dong
authors.forename: Y P
authors.initials: YP
authors.lastname: Wang
mesh_terms: D001479:Basal Ganglia; D001921:Brain; D007562:Creutzfeldt-Jakob Syndrome; D018450:Disease Progression; D006801:Humans; D008279:Magnetic Resonance Imaging; D012189:Retrospective Studies