title: Contact sensitization in Dutch children and adolescents with and without atopic dermatitis - a retrospective analysis.
abstract: BACKGROUND
  Allergic contact dermatitis is known to occur in children with and without atopic dermatitis, but more data are needed on contact sensitization profiles in these two groups.
  
  
  OBJECTIVE
  To identify frequent allergens in children with and without atopic dermatitis suspected of having allergic contact dermatitis.
  
  
  METHODS
  A retrospective analysis of children aged 0-17 years patch tested between 1996 and 2013 was performed.
  
  
  RESULTS
  Of all 1012 children tested because of suspected contact dermatitis, 46% developed one or more positive reactions, the proportions for children with (n = 526) and without (n = 395) atopic dermatitis being 48% and 47%, respectively. Children with atopic dermatitis reacted more often to lanolin alcohol (30% pet., p = 0.030), Amerchol L-101 (p = 0.030), and fragrances [fragrance mix I (p = 0.048) and Myroxylon pereirae (p = 0.005)]. Allergens outside the European baseline series that frequently gave positive reactions in these groups included cocamidopropyl betaine and Amerchol L-101. Reactivity to these allergens was significantly more common in atopic dermatitis children.
  
  
  CONCLUSIONS
  Sensitization prevalences in children with and without atopic dermatitis were similar, but children with atopic dermatitis reacted significantly more often to lanolin alcohol and fragrances. Testing with additional series besides the European baseline series may be necessary, as reactions to, for example, cocamidopropyl betaine and Amerchol L-101 may otherwise be missed.
authors.affiliation: Department of Dermatology, Academic Medical Centre, University of Amsterdam, 1100 DD Amsterdam, The Netherlands.
authors.forename: Stefanie
authors.initials: S
authors.lastname: Lubbes
authors.affiliation: Department of Dermatology, VU University Medical Centre, 1081 HV Amsterdam, The Netherlands.
authors.forename: Thomas
authors.initials: T
authors.lastname: Rustemeyer
authors.affiliation: Department of Dermatology, Academic Medical Centre, University of Amsterdam, 1100 DD Amsterdam, The Netherlands.
authors.forename: Johannes H
authors.initials: JH
authors.lastname: Sillevis Smitt
authors.affiliation: Department of Dermatology, University Medical Centre Groningen, 9700 RB, Groningen, The Netherlands.
authors.forename: Marie Louise
authors.initials: ML
authors.lastname: Schuttelaar
authors.affiliation: Department of Dermatology, Academic Medical Centre, University of Amsterdam, 1100 DD Amsterdam, The Netherlands.
authors.forename: Maritza A
authors.initials: MA
authors.lastname: Middelkamp-Hup
mesh_terms: D000293:Adolescent; D000485:Allergens / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis* / Q000453:epidemiology; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009426:Netherlands; D010328:Patch Tests; D015995:Prevalence; D012189:Retrospective Studies; D018570:Risk Assessment
chemical_list: D000485:Allergens
keywords: allergic contact dermatitis; atopic dermatitis; children; contact allergy; contact dermatitis; delayed-type hypersensitivity; patch testing