title: Extending Previous cG×I Findings on 5-HTTLPR's Moderation of Intervention Effects on Adolescent Substance Misuse Initiation.
abstract: This study addresses replication in candidate gene × environment interaction (cG×E) research by investigating if the key findings from Brody, Beach, Philibert, Chen, and Murry (2009) can be detected using data (N = 1,809) from the PROSPER substance use preventive intervention delivery system. Parallel to Brody et al., this study tested the hypotheses that substance misuse initiation would increase faster from age 11 to age 14 and be higher at age 14 among: (a) 5-HTTLPR short carrier adolescents versus long homozygotes, (b) control versus intervention adolescents, and (c) 5-HTTLPR short carriers in the control condition versus all other participants. The hypotheses were generally supported and results were consistent with Brody et al.'s cG×I finding. Results are discussed in light of replication issues in cG×E research and implications for intervention.
authors.affiliation: University at Albany, SUNY.
authors.forename: Gabriel L
authors.initials: GL
authors.lastname: Schlomer
authors.affiliation: The Pennsylvania State University.
authors.forename: H Harrington
authors.initials: HH
authors.lastname: Cleveland
authors.affiliation: The Pennsylvania State University.
authors.forename: Mark E
authors.initials: ME
authors.lastname: Feinberg
authors.affiliation: The Pennsylvania State University.
authors.forename: Pedro S A
authors.initials: PSA
authors.lastname: Wolf
authors.affiliation: The Pennsylvania State University.
authors.forename: Mark T
authors.initials: MT
authors.lastname: Greenberg
authors.affiliation: Iowa State University.
authors.forename: Richard L
authors.initials: RL
authors.lastname: Spoth
authors.affiliation: Iowa State University.
authors.forename: Cleve
authors.initials: C
authors.lastname: Redmond
authors.affiliation: The Pennsylvania State University.
authors.forename: Eric P
authors.initials: EP
authors.lastname: Tricou
authors.affiliation: The Pennsylvania State University.
authors.forename: David J
authors.initials: DJ
authors.lastname: Vandenbergh
mesh_terms: D000293:Adolescent; D000294:Adolescent Behavior / Q000523:psychology*; D002648:Child; D005260:Female; D059647:Gene-Environment Interaction; D006801:Humans; D008297:Male; D012309:Risk-Taking; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D019966:Substance-Related Disorders / Q000235:genetics* / Q000523:psychology*
chemical_list: C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins