title: Maternal venous SHARP1 levels in preeclampsia.
abstract: OBJECTIVE
  Owing to its mysterious etiology, pathogenesis of preeclampsia (PE) remains controversial. Here we aimed to compare the levels of an angiogenesis marker, split and hairy related protein-1 (SHARP1), in PE vs. normal pregnancy.
  
  
  METHODS
  Thirty-one patients with early-onset PE (EOPE), 26 patients with late-onset PE (LOPE), and 33 patients as a control group were recruited for this study in a tertiary referral center in Ankara, Turkey. Maternal venous SHARP1 levels and individual characteristics of the three groups were compared.
  
  
  RESULTS
  Age and body mass indices were similar among the three groups. SHARP1 levels in patients with PE (27.7±13.2 ng/mL) were significantly lower than in the control group (34.7±17 ng/mL) (P=0.006). Additionally, SHARP1 levels were significantly different among patients in EOPE, LOPE, and control groups (P=0.022). Birth weights and Apgar scores in patients in EOPE group were significantly lower than the other two groups and showed a gradual increase from the EOPE group to the LOPE and the control group. Binary logistic regression method demonstrated that maternal venous SHARP1 level was a risk factor for PE.
  
  
  CONCLUSIONS
  Maternal venous SHARP1 levels in PE are lower than a normal pregnancy. Its clinical applicability and role as a candidate for making sense of the distinctive pathogenesis of the EOPE and LOPE remain to be elucidated.
authors.affiliation: .
authors.forename: Ali Ozgur
authors.identifier: http://orcid.org/0000-0003-1137-7017
authors.initials: AO
authors.lastname: Ersoy
authors.affiliation: .
authors.forename: Efser
authors.initials: E
authors.lastname: Oztas
authors.affiliation: .
authors.forename: Sibel
authors.initials: S
authors.lastname: Ozler
authors.affiliation: .
authors.forename: Aytekin
authors.initials: A
authors.lastname: Tokmak
authors.affiliation: .
authors.forename: Ebru
authors.initials: E
authors.lastname: Ersoy
authors.affiliation: .
authors.forename: Merve
authors.initials: M
authors.lastname: Ergin
authors.affiliation: .
authors.forename: Nuri
authors.initials: N
authors.lastname: Danisman
mesh_terms: D051792:Basic Helix-Loop-Helix Proteins / Q000097:blood*; D016021:Epidemiologic Studies; D005260:Female; D006801:Humans; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; C422085:BHLHE41 protein, human
keywords: Angiogenesis; SHARP1; early onset; late onset; marker; preeclampsia