title: Level of serum thioredoxin and correlation with neurocognitive functions in patients with schizophrenia using clozapine and other atypical antipsychotics.
abstract: Thioredoxin is a serum antioxidant that has been investigated in the etiology of schizophrenia. The aim of this study is investigating the relationship between serum thioredoxin levels and cognitive functions in acute psychotic episode and remission state patients with schizophrenia; and examining whether there were differences between patients using clozapine and other atypical antipsychotics; including risperidone, olanzapine and amisulpride. This research was performed in schizophrenia patients hospitalized with acute psychotic episode (n=57), reevaluated patients after the initiation of treatment (mean 16 weeks) (n=46), and healthy controls (n=41). Positive and Negative Syndrome Scale, Clinic Global Impressions Scale, Neuropsychologic test battery to assess cognitive performance, and serum thioredoxin levels measured by ELISA were used in this research. Serum thioredoxin levels were highest in acute psychotic episode, lower in the remission state and the lowest in healthy controls. Significant correlation has been established between serum thioredoxin levels and Trail Making Test-A performance in remission state patients. In conclusion, serum thioredoxin levels were increased in acute psychotic episode and decreased in remission state, and its relationship with attention is worth to consider in schizophrenia patients.
authors.affiliation: Department of Psychiatry, Aksaray State Hospital, Aksaray, Turkey. Electronic address: alperbas@outlook.com.
authors.forename: Alper
authors.initials: A
authors.lastname: Bas
authors.affiliation: Department of Psychiatry, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul,Turkey.
authors.forename: Gozde
authors.initials: G
authors.lastname: Gultekin
authors.affiliation: Clinical Laboratory, Koc University Hospital, Istanbul, Turkey.
authors.forename: Said
authors.initials: S
authors.lastname: Incir
authors.affiliation: Department of Psychiatry, Aksaray State Hospital, Aksaray, Turkey.
authors.forename: Tuba Ocek
authors.initials: TO
authors.lastname: Bas
authors.affiliation: Department of Psychiatry, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul,Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Emul
authors.affiliation: Department of Psychiatry, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul,Turkey.
authors.forename: Alaatin
authors.initials: A
authors.lastname: Duran
mesh_terms: D000328:Adult; D000077582:Amisulpride; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001569:Benzodiazepines / Q000627:therapeutic use; D003024:Clozapine / Q000627:therapeutic use*; D003071:Cognition / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D000077152:Olanzapine; D011618:Psychotic Disorders / Q000188:drug therapy; D018967:Risperidone / Q000627:therapeutic use; D012559:Schizophrenia / Q000097:blood* / Q000188:drug therapy / Q000503:physiopathology; D013469:Sulpiride / Q000031:analogs & derivatives / Q000627:therapeutic use; D013879:Thioredoxins / Q000097:blood*; D055815:Young Adult
chemical_list: D014150:Antipsychotic Agents; C491203:TXN protein, human; D001569:Benzodiazepines; D013879:Thioredoxins; D013469:Sulpiride; D000077582:Amisulpride; D003024:Clozapine; D018967:Risperidone; D000077152:Olanzapine
keywords: Cognition; Oxidative stress; Schizophrenia; Thioredoxin