title: Vancouver Experience of Recombinant Human Platelet-Derived Growth Factor.
abstract: Joint arthrodesis utilizing autogenous bone graft remains the gold standard of treatment in fusion procedures of the foot and ankle. Graft harvest, however, has been associated with increased morbidity to patients as well as increased costs. With this in mind, multiple clinical studies have evaluated the efficacy of recombinant human platelet-derived growth factor (rh-PDGF-BB) with beta-tricalcium phosphate (B-TCP) to augment in foot and ankle arthrodesis with favorable results. These factors have led to the increased use of rh-PDGF-BB with B-TCP in Vancouver with good clinical results.
authors.affiliation: Department of Orthopedics, University of British Columbia, 560-1144 Burrard Street, Vancouver, British Columbia V6Z 2A5, Canada. Electronic address: asyounger@shaw.ca.
authors.forename: Alistair
authors.initials: A
authors.lastname: Younger
authors.affiliation: Department of Orthopedics, University of British Columbia, 1000-1200 Burrard Street, Vancouver, British Columbia V6Z 2C7, Canada.
authors.forename: Murray
authors.initials: M
authors.lastname: Penner
authors.affiliation: Department of Orthopedics, University of British Columbia, 560-1144 Burrard Street, Vancouver, British Columbia V6Z 2A5, Canada.
authors.forename: Harvey E
authors.initials: HE
authors.lastname: Montijo
mesh_terms: D000843:Ankle Joint / Q000601:surgery; D001174:Arthrodesis / Q000379:methods*; D000077214:Becaplermin; D016025:Bone Transplantation; D001955:British Columbia; D002130:Calcium Phosphates / Q000494:pharmacology / Q000627:therapeutic use*; D005528:Foot / Q000601:surgery*; D017102:Fracture Healing / Q000187:drug effects* / Q000502:physiology; D005599:Fractures, Ununited / Q000188:drug therapy*; D006801:Humans; D020574:Proto-Oncogene Proteins c-sis / Q000494:pharmacology / Q000627:therapeutic use*; D016032:Randomized Controlled Trials as Topic
chemical_list: D002130:Calcium Phosphates; D020574:Proto-Oncogene Proteins c-sis; C485817:beta-tricalcium phosphate; D000077214:Becaplermin
keywords: Bone graft substitute; Foot and ankle arthrodesis; Fusion; PDGF, Platelet-derived growth factor; Recombinant human platelet-derived growth factor