title: The influence of atherosclerotic plaques on the pharmacokinetics of a drug eluted from bioabsorbable stents.
abstract: In this paper the effect of plaque composition, on the accumulation of drug released by a drug eluting stent, is analyzed. The mathematical model is represented by two coupled systems of partial differential equations that describe the pharmacokinetics of drug in the stent coating and in the arterial wall. The influence of the stiffness and porosity of soft and hard plaques is studied. A case study based on optical coherence tomography images is also included.
authors.affiliation: CMUC, Department of Mathematics, University of Coimbra, 3001-454, Coimbra, Portugal.
authors.forename: José A
authors.initials: JA
authors.lastname: Ferreira
authors.affiliation: ServiÃ§o de Cardiologia do Centro Hospitalar e UniversitÃ¡rio de Coimbra-Hospital Geral, Faculdade de Medicina da Universidade de Coimbra, Coimbra, Portugal.
authors.forename: Lino
authors.initials: L
authors.lastname: Gonçalves
authors.affiliation: Institute of Structural Mechanics, Bauhaus University of Weimar, 99423, Weimar, Germany. Electronic address: jahed.naghipoor@uni-weimar.de.
authors.forename: Jahed
authors.initials: J
authors.lastname: Naghipoor
authors.affiliation: CMUC, Department of Mathematics, University of Coimbra, 3001-454, Coimbra, Portugal.
authors.forename: Paula
authors.initials: P
authors.lastname: de Oliveira
authors.affiliation: Institute of Structural Mechanics, Bauhaus University of Weimar, 99423, Weimar, Germany. Electronic address: timon.rabczuk@uni-weimar.de.
authors.forename: Timon
authors.initials: T
authors.lastname: Rabczuk
mesh_terms: D020341:Absorbable Implants; D000970:Antineoplastic Agents / Q000493:pharmacokinetics*; D001158:Arteries / Q000473:pathology*; D054855:Drug-Eluting Stents; D008962:Models, Theoretical; D017239:Paclitaxel / Q000493:pharmacokinetics*; D058226:Plaque, Atherosclerotic / Q000473:pathology*; D020123:Sirolimus / Q000493:pharmacokinetics*
chemical_list: D000970:Antineoplastic Agents; D017239:Paclitaxel; D020123:Sirolimus
keywords: Atherosclerotic plaque; Drug eluting stent; Numerical simulation; Porosity