title: Effect of Erythropoietin on Postresuscitation Renal Function in a Swine Model of Ventricular Fibrillation.
abstract: Purpose. To investigate the effect of EPO administration on postresuscitation renal function.Methods. Twenty-four female Landrace/Large-White piglets aged 10-15 weeks with average weight of 19 ± 2 kg were randomly assigned to 2 different groups of 12 subjects each. After the end of an 8-minute ventricular fibrillation, the control group (Group C) received saline as placebo, whereas the EPO group (Group E) received EPO 5000 U/kg. The animals were resuscitated according to the 2010 European Resuscitation Council Guidelines for Resuscitation.Results. Five animals (41.67%) from Group C and 11 animals (91.67%) from Group E achieved ROSC (p= 0.027). Eight animals (66.67%, 5 surviving and 3 nonsurviving) from Group C suffered severe kidney damage or AKI compared to animals from Group E, in which none of the swine had evidence of severe kidney damage or AKI (p= 0.001). There was a statistically significant difference in all tested biochemical markers between the two groups, as well as a positive correlation of creatinine with NGAL, L-FABP, and IL-18 (summed mean values'p= 0.049, 0.01, and 0.004, resp.).Conclusions. Administration of EPO protected swine from postresuscitation acute kidney injury.
authors.affiliation: Department of Anaesthetics, Liver Transplant Unit, King's College Hospital, London, UK.
authors.forename: Charalampos
authors.identifier: 0000-0002-1620-6420
authors.initials: C
authors.lastname: Pantazopoulos
authors.affiliation: Neonatology Department, Aretaieio Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
authors.forename: Nicoletta
authors.identifier: 0000-0001-8021-6191
authors.initials: N
authors.lastname: Iacovidou
authors.affiliation: Department of Biopathology, Aretaieio Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
authors.forename: Evangelia
authors.initials: E
authors.lastname: Kouskouni
authors.affiliation: MSc "Cardiopulmonary Resuscitation", Medical School, National and Kapodistrian University of Athens, Athens, Greece.
authors.forename: Paraskevi
authors.initials: P
authors.lastname: Pliatsika
authors.affiliation: ELPEN Research-Experimental Centre, Athens, Greece.
authors.forename: Apostolos
authors.identifier: 0000-0001-8339-7426
authors.initials: A
authors.lastname: Papalois
authors.affiliation: Department of Biopathology, Aretaieio Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
authors.forename: Georgios
authors.initials: G
authors.lastname: Kaparos
authors.affiliation: MSc "Cardiopulmonary Resuscitation", Medical School, National and Kapodistrian University of Athens, Athens, Greece.
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Barouxis
authors.affiliation: MSc "Cardiopulmonary Resuscitation", Medical School, National and Kapodistrian University of Athens, Athens, Greece.
authors.forename: Panagiotis
authors.identifier: 0000-0002-6739-0619
authors.initials: P
authors.lastname: Vasileiou
authors.affiliation: MSc "Cardiopulmonary Resuscitation", Medical School, National and Kapodistrian University of Athens, Athens, Greece.
authors.forename: Pavlos
authors.initials: P
authors.lastname: Lelovas
authors.affiliation: MSc "Cardiopulmonary Resuscitation", Medical School, National and Kapodistrian University of Athens, Athens, Greece.
authors.forename: Olympia
authors.initials: O
authors.lastname: Kotsilianou
authors.affiliation: MSc "Cardiopulmonary Resuscitation", Medical School, National and Kapodistrian University of Athens, Athens, Greece.
authors.forename: Ioannis
authors.initials: I
authors.lastname: Pantazopoulos
authors.affiliation: 2nd Department of Surgery, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
authors.forename: Georgios
authors.initials: G
authors.lastname: Gkiokas
authors.affiliation: Division of Pathology, Department of Surgical Sciences, University of Cagliari Medical School, Cagliari, Italy.
authors.forename: Clara
authors.initials: C
authors.lastname: Garosa
authors.affiliation: Division of Pathology, Department of Surgical Sciences, University of Cagliari Medical School, Cagliari, Italy.
authors.forename: Gavino
authors.identifier: 0000-0003-3768-0890
authors.initials: G
authors.lastname: Faa
authors.affiliation: School of Medicine, European University Cyprus, Nicosia, Cyprus.
authors.forename: Theodoros
authors.identifier: 0000-0003-3670-9305
authors.initials: T
authors.lastname: Xanthos
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control; D000818:Animals; D004921:Erythropoietin / Q000494:pharmacology*; D005260:Female; D007668:Kidney / Q000473:pathology / Q000503:physiopathology*; D012151:Resuscitation / Q000009:adverse effects*; D013552:Swine; D014693:Ventricular Fibrillation / Q000628:therapy*
chemical_list: C554270:EPO protein, human; D004921:Erythropoietin