title: 30 Years Retrospective Review of Tuberculosis Cases in a Tuberculosis Dispensary in Bursa/Nilufer, Turkey (1985-2014): Changes of Epidemics.
abstract: OBJECTIVE
  The aim of this study is to describe the epidemiological and clinical aspects of patients who applied to the Bursa Nilufer Tuberculosis Dispensary by investigating the trends in epidemics over three decades.
  
  
  METHODS
  In this retrospective observational study, the records of all tuberculosis cases (1630 patients) treated in the last 30 years (1985-2014) at the Bursa Nilufer Tuberculosis Dispensary were examined and statistically analyzed.
  
  
  RESULTS
  Males comprised 65.2% of the patients. The ages of the patients ranged from 1 to 87 years, and the mean age was 37.4 (95% CI: 36.6-38.2). Among the cases, 86.7% were new infections and 74.1% were pulmonary tuberculosis. In the last decade, the education level, the percentage of patients who had received a BCG vaccination, the proportion of women and active employees among them increased (p<0.05), while it decreased among men (p<0.05). Clinical symptoms accompanying TB such as weakness, anorexia, weight loss, and cough, decreased to a statistically significant degree (p<0.05). In the last decade, the mortality rate was 3.6% and increased compared with previous decades (p<0.05). Mortality was higher among patients who were elderly, male, did not have a BCG scar or had a chronic disease (p<0.05).
  
  
  CONCLUSIONS
  This study adds information about the change of TB epidemics in Turkey in the last 30 years. Further studies are needed to determine the risk factors associated with tuberculosis mortality and to evaluate the effectiveness control programs of this disease.
authors.affiliation: Public Health Department, Uludag University Faculty of Medicine, Bursa, Turkey.
authors.forename: Kayıhan
authors.initials: K
authors.lastname: Pala
authors.affiliation: Public Health Department, Uludag University Faculty of Medicine, Bursa, Turkey.
authors.forename: Harika
authors.initials: H
authors.lastname: Gerçek
authors.affiliation: Public Health Department, Uludag University Faculty of Medicine, Bursa, Turkey.
authors.forename: Tuncay Aydin
authors.initials: TA
authors.lastname: Taş
authors.affiliation: Public Health Department, Uludag University Faculty of Medicine, Bursa, Turkey.
authors.forename: Rukiye
authors.initials: R
authors.lastname: Çakir
authors.affiliation: Nilufer Tuberculosis Control Association Dispensary, Bursa, Turkey.
authors.forename: Sedef
authors.initials: S
authors.lastname: Özgüç
authors.affiliation: Nilufer Tuberculosis Control Association Dispensary, Bursa, Turkey.
authors.forename: Timur
authors.initials: T
authors.lastname: Yildiz