title: Current progress of human trials using stem cell therapy as a treatment for diabetes mellitus.
abstract: Diabetes mellitus affects millions of people worldwide, and is associated with serious complications that affect nearly all body systems. Because of the severity of this global health concern, there is a great deal of research being performed on alternative treatments and possible cures. Previous treatments for diabetes have included exogenous insulin injection and pancreatic islet transplantations. These treatment methods have several limitations; thus, the use of stem cells in treating diabetes is currently a significant area of research. This review outlines current research on stem cell therapy for diabetes mellitus. Numerous studies have been performed on animals using various types of stem cells, including mesenchymal stem cells and embryonic stem cells. Moreover, results and limitations of animal studies have been confirmed in various clinical trials. Overall, stem cell treatment shows prospective advantages over insulin injections and other current treatment options, and ongoing clinical trials suggest that this therapy may be a viable treatment option for diabetics in the near future.
authors.affiliation: Georgetown University School of Medicine, Georgetown University Medical Center Washington DC, USA.
authors.forename: Shuk Kei
authors.initials: SK
authors.lastname: Cheng
authors.affiliation: Georgetown University School of Medicine, Georgetown University Medical Center Washington DC, USA.
authors.forename: Elisse Y
authors.initials: EY
authors.lastname: Park
authors.affiliation: Georgetown University School of Medicine, Georgetown University Medical Center Washington DC, USA.
authors.forename: Andjela
authors.initials: A
authors.lastname: Pehar
authors.affiliation: Georgetown University School of Medicine, Georgetown University Medical Center Washington DC, USA.
authors.forename: Alexandra C
authors.initials: AC
authors.lastname: Rooney
authors.affiliation: Georgetown University School of Medicine, Georgetown University Medical CenterWashington DC, USA; Department of Biochemistry and Molecular and Cellular Biology, Georgetown University Medical CenterWashington DC, USA.
authors.forename: G Ian
authors.initials: GI
authors.lastname: Gallicano
keywords: Diabetes; IPS cells; adult stem cells; embryonic stem cells; human trials; spermatogonial stem cells