title: Conducting an Oral Food Challenge to Peanut in an Infant.
abstract: Results from the Learning Early About Peanut trial and its follow-up study suggest that early peanut introduction in the diets of high-risk infants may prevent the development of peanut allergy. Allergy organizations around the world released a unified statement, the Consensus Communication on Early Peanut Introduction and the Prevention of Peanut Allergy in High Risk Infants, in response to results from the Learning Early About Peanut trial, which recommends early introduction of peanut into the diet of those children at greatest risk of development of peanut allergy. As a result, it is expected that practicing allergists will experience an increased demand to perform an oral food challenge (OFC) in infants. Allergists often perform OFCs; however, conducting an OFC in an infant creates unique circumstances that have not been considered in previously published OFC guideline documents. The purpose of this workgroup report is to provide guidance to practitioners regarding the proper approach for conducting a peanut challenge in an infant.
authors.affiliation: Division of Pediatric Allergy and Immunology, University of Texas Southwestern Medical Center, Dallas, Tex; Food Allergy Center, Children's Medical Center, Dallas, Tex. Electronic address: drew.bird@utsouthwestern.edu.
authors.forename: J Andrew
authors.initials: JA
authors.lastname: Bird
authors.affiliation: Jaffe Food Allergy Institute, Division of Pediatric Allergy, Icahn School of Medicine at Mount Sinai, New York, NY.
authors.forename: Marion
authors.initials: M
authors.lastname: Groetch
authors.affiliation: Population Health, The Murdoch Children's Research Institute, Parkville, Australia; Department of Paediatrics, University of Melbourne, Parkville, Australia; Department of Allergy and Immunology, Royal Children's Hospital, Parkville, Australia.
authors.forename: Katrina J
authors.initials: KJ
authors.lastname: Allen
authors.affiliation: Boulder Valley Asthma and Allergy Clinic, Boulder, Colo.
authors.forename: S Allan
authors.initials: SA
authors.lastname: Bock
authors.affiliation: Division of Pediatric Allergy & Immunology, Rady Children's Hospital San Diego, University of California, San Diego, Calif.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Leonard
authors.affiliation: Jaffe Food Allergy Institute, Division of Pediatric Allergy, Icahn School of Medicine at Mount Sinai, New York, NY.
authors.forename: Anna H
authors.initials: AH
authors.lastname: Nowak-Wegrzyn
authors.affiliation: Jaffe Food Allergy Institute, Division of Pediatric Allergy, Icahn School of Medicine at Mount Sinai, New York, NY.
authors.forename: Scott
authors.initials: S
authors.lastname: Sicherer
authors.affiliation: Food Allergy Center, Children's Medical Center, Dallas, Tex.
authors.forename: April
authors.initials: A
authors.lastname: Clark
authors.affiliation: Department of Pediatrics, University of Colorado Denver School of Medicine and Children's Hospital Colorado, Aurora, Colo.
authors.forename: David M
authors.initials: DM
authors.lastname: Fleischer
authors.affiliation: Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
authors.forename: Carina
authors.initials: C
authors.lastname: Venter
authors.affiliation: Division of Pediatric Allergy, Immunology and Rheumatology, University of North Carolina, Chapel Hill, NC.
authors.forename: Brian
authors.initials: B
authors.lastname: Vickery
authors.affiliation: Division of Allergy and Immunology, Children's Hospital Boston, Harvard Medical School, Boston, Mass.
authors.forename: Michael C
authors.initials: MC
authors.lastname: Young
mesh_terms: D000284:Administration, Oral; D000485:Allergens / Q000276:immunology*; D010367:Arachis / Q000276:immunology*; D003245:Consensus Statements as Topic; D004032:Diet; D006801:Humans; D007114:Immunization / Q000379:methods*; D007223:Infant; D007231:Infant, Newborn; D021183:Peanut Hypersensitivity / Q000276:immunology* / Q000517:prevention & control*
chemical_list: D000485:Allergens
keywords: Early introduction; Food allergy; Infant; LEAP; Oral food challenge; Peanut allergy