title: Antineutrophil cytoplasmic antibodies crescentic allograft glomerulonephritis after sofosbuvir therapy.
abstract: Antineutrophil cytoplasmic antibodies (ANCA) are well known to be associated with several types of vasculitis, including pauci-immune crescentic glomerulonephritis, a form of rapid progressive glomerular nephritis (RPGN). ANCA vasculitis has also been reported after administration of propylthiouracil, hydralazine, cocaine (adulterated with levimasole), allopurinol, penicillamine and few other drugs. All previously reported cases of drug-associated ANCA glomerulonephritis were in native kidneys. Sofosbuvir is a new and effective drug for hepatitis C virus infection. Here, we report a case of ANCA vasculitis and RPGN following sofosbuvir administration in a kidney transplant recipient. It also represents the first case of drug-associated ANCA vasculitis in a transplanted kidney. Further drug monitoring is necessary to elucidate the degree of association and possible causal effect of sofosbuvir and perinuclear ANCA vasculitis.
authors.affiliation: Shilpa Gadde, Belinda Lee, Laura Kidd, Rubin Zhang, Department of Nephrology and Hypertension, Tulane University School of Medicine, New Orleans, LA 70112, United States.
authors.forename: Shilpa
authors.initials: S
authors.lastname: Gadde
authors.affiliation: Shilpa Gadde, Belinda Lee, Laura Kidd, Rubin Zhang, Department of Nephrology and Hypertension, Tulane University School of Medicine, New Orleans, LA 70112, United States.
authors.forename: Belinda
authors.initials: B
authors.lastname: Lee
authors.affiliation: Shilpa Gadde, Belinda Lee, Laura Kidd, Rubin Zhang, Department of Nephrology and Hypertension, Tulane University School of Medicine, New Orleans, LA 70112, United States.
authors.forename: Laura
authors.initials: L
authors.lastname: Kidd
authors.affiliation: Shilpa Gadde, Belinda Lee, Laura Kidd, Rubin Zhang, Department of Nephrology and Hypertension, Tulane University School of Medicine, New Orleans, LA 70112, United States.
authors.forename: Rubin
authors.initials: R
authors.lastname: Zhang
keywords: Antineutrophil cytoplasmic antibody; Crescentic glomerulonephritis; Kidney transplant; Sofosbuvir; Vasculitis