title: Outcomes of allogeneic hematopoietic stem cell transplantation for lymphomas: a single-institution experience.
abstract: BACKGROUND
  Allogeneic hematopoietic stem cell transplantation offers the opportunity for extended survival in patients with Hodgkin's and non-Hodgkin lymphomas who relapsed after, or were deemed ineligible for, autologous transplantation. This study reports the cumulative experience of a single center over the past 14 years aiming to define the impact of patient, disease, and transplant-related characteristics on outcomes.
  
  
  METHODS
  All patients with histologically confirmed diagnosis of Hodgkin's or non-Hodgkin lymphomas who received allogeneic transplantation from 2000 to 2014 were retrospectively studied.
  
  
  RESULTS
  Forty-one patients were reviewed: 10 (24%) had Hodgkin's and 31 (76%) had non-Hodgkin lymphomas. The median age was 50 years and 23 (56%) were male. The majority of patients (68%) had had a prior autologous transplantation. At the time of allogeneic transplantation, 18 (43%) patients were in complete and seven (17%) were in partial remission. Most (95%) patients received reduced-intensity conditioning, 49% received matched sibling donor grafts, 24% matched-unrelated donor grafts, and 27% received double umbilical cord blood grafts. The 100-day treatment-related mortality rate was 12%. After a median duration of follow up of 17.1 months, the median progression-free and overall survival was 40.5 and 95.8 months, respectively. On multivariate analysis, patients who had active disease at the time of transplant had inferior survival.
  
  
  CONCLUSIONS
  Allogeneic transplantation results extend survival in selected patients with relapsed/refractory Hodgkin's and non-Hodgkin lymphomas with low treatment-related mortality. Patients who have active disease at the time of allogeneic transplantation have poor outcomes.
authors.affiliation: University Hospitals Case Medical Center, Cleveland, United States.
authors.forename: Mira Romany
authors.initials: MR
authors.lastname: Massoud
authors.affiliation: University Hospitals Case Medical Center, Cleveland, United States; Case Western Reserve University, Cleveland, United States.
authors.forename: Paolo Fabrizio
authors.initials: PF
authors.lastname: Caimi
authors.affiliation: University Hospitals Case Medical Center, Cleveland, United States.
authors.forename: Nicole
authors.initials: N
authors.lastname: Ferrari
authors.affiliation: Case Western Reserve University, Cleveland, United States.
authors.forename: Pingfu
authors.initials: P
authors.lastname: Fu
authors.affiliation: University Hospitals Case Medical Center, Cleveland, United States.
authors.forename: Richard
authors.initials: R
authors.lastname: Creger
authors.affiliation: University Hospitals Case Medical Center, Cleveland, United States.
authors.forename: Robert
authors.initials: R
authors.lastname: Fox
authors.affiliation: University Hospitals Case Medical Center, Cleveland, United States.
authors.forename: Joanne
authors.initials: J
authors.lastname: Carlson-Barko
authors.affiliation: University Hospitals Case Medical Center, Cleveland, United States.
authors.forename: Merle
authors.initials: M
authors.lastname: Kolk
authors.affiliation: University Hospitals Case Medical Center, Cleveland, United States.
authors.forename: Lauren
authors.initials: L
authors.lastname: Brister
authors.affiliation: University Hospitals Case Medical Center, Cleveland, United States; Case Western Reserve University, Cleveland, United States.
authors.forename: Brenda Wimpfheimer
authors.initials: BW
authors.lastname: Cooper
authors.affiliation: University Hospitals Case Medical Center, Cleveland, United States; Case Western Reserve University, Cleveland, United States.
authors.forename: Stanton
authors.initials: S
authors.lastname: Gerson
authors.affiliation: University Hospitals Case Medical Center, Cleveland, United States; Case Western Reserve University, Cleveland, United States.
authors.forename: Hillard Michael
authors.initials: HM
authors.lastname: Lazarus
authors.affiliation: University Hospitals Case Medical Center, Cleveland, United States; Case Western Reserve University, Cleveland, United States.
authors.forename: Marcos
authors.initials: M
authors.lastname: de Lima
authors.affiliation: University Hospitals Case Medical Center, Cleveland, United States; Case Western Reserve University, Cleveland, United States. Electronic address: basem.william@ousmc.edu.
authors.forename: Basem Magdy
authors.initials: BM
authors.lastname: William
keywords: Lymphoma, Hodgkin's; Lymphoma, non-Hodgkin; Transplantation, hematopoietic, allogeneic