title: Investigation of IL23R, JAK2, and STAT3 gene polymorphisms and gene-gene interactions in Crohn's disease and ulcerative colitis in a Turkish population.
abstract: OBJECTIVE
  Inflammatory bowel diseases are chronic, relapsing, inflammatory conditions. They have a genetic backround resulting in patient susceptibility. The aim of our study is to investigate the involvement of IL23R, JAK2, and STAT3 polymorphisms in inflammatory bowel diseases in a Turkish population.
  
  
  METHODS
  Polymorphisms in IL23R (rs11209026), JAK2 (rs10758669), and STAT3 (rs3816769, rs2293152, rs744166, rs957970, rs8074524) were genotyped in 69 Crohn's disease patients, 157 ulcerative colitis patients, and 89 healthy controls.
  
  
  RESULTS
  The presence of (C) in rs10758669, (T) and (TT) in rs957970, and (TT) in rs744166 were found to increase the susceptibility to Crohn's disease (p=0.049, p=0.016, p=0.010, p=0.035, respectively), while rs2293152 (GC), rs744166 (CT), and rs957970 (CT) provide protection against Crohn's disease (p=0.007, p=0.043, p=0.043, respectively). While rs2293152 (GC) was protective, rs2293152 (CC) increased the susceptibility to ulcerative colitis (p=0.009, p=0.001). All the polymorphisms were associated with age-at-diagnosis, except rs11209026. Furthermore, rs2293152 was associated with an extension in ulcerative colitis, while rs10758669, rs3816769, rs744166, rs2293152, and rs957970 were associated with the subphenotype in Crohn's disease. The presence of rs10758669 (AC) was protective against perianal Crohn's disease (p=0.016). Additionally, rs10758669 and rs2293152 in Crohn's disease and rs8074524, rs3816769, and rs10758669 in ulcerative colitis were associated with the requirement of immunsuppression. Finally, rs8074524 and rs10758669 in Crohn's disease and rs11209026 in ulcerative colitis were associated with disease-related operation.
  
  
  CONCLUSIONS
  This is the first study of the single marker association of IL23R, JAK2, and STAT3 polymorphisms with ulcerative colitis and Crohn's disease in a Turkish population. It was demonstrated that these polymorphisms may be effective in the etiology of inflammatory bowel disease in this Turkish population.
authors.affiliation: Department of Gastroenterology, Abant İzzet Baysal University School of Medicine, Bolu, Turkey. dr_guraycan@yahoo.com.
authors.forename: Güray
authors.initials: G
authors.lastname: Can
authors.forename: Ahmet
authors.initials: A
authors.lastname: Tezel
authors.forename: Hakan
authors.initials: H
authors.lastname: Gürkan
authors.forename: Hilmi
authors.initials: H
authors.lastname: Tozkır
authors.forename: Gülbin
authors.initials: G
authors.lastname: Ünsal
authors.forename: Ali Rıza
authors.initials: AR
authors.lastname: Soylu
authors.forename: Hasan Celalettin
authors.initials: HC
authors.lastname: Ümit
mesh_terms: D000328:Adult; D017668:Age of Onset; D000483:Alleles; D016022:Case-Control Studies; D003093:Colitis, Ulcerative / Q000188:drug therapy / Q000235:genetics* / Q000601:surgery; D003424:Crohn Disease / Q000188:drug therapy / Q000235:genetics* / Q000601:surgery; D004843:Epistasis, Genetic; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D053614:Janus Kinase 2 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D065840:Protective Factors; D018123:Receptors, Interleukin / Q000235:genetics*; D012307:Risk Factors; D050796:STAT3 Transcription Factor / Q000235:genetics*; D014421:Turkey
chemical_list: C515500:IL23R protein, human; D007166:Immunosuppressive Agents; D018123:Receptors, Interleukin; D050796:STAT3 Transcription Factor; C494086:STAT3 protein, human; C507924:JAK2 protein, human; D053614:Janus Kinase 2