title: Comparison of the accuracy of US-guided biopsy of breast masses performed with 14-gauge, 16-gauge and 18-gauge automated cutting needle biopsy devices, and review of the literature.
abstract: OBJECTIVE
  To compare the diagnostic accuracy of ultrasound (US)-guided core needle biopsy (CNB) of breast masses performed with 14-gauge, 16-gauge and 18-gauge needles.
  
  
  METHODS
  We retrospectively reviewed the charts of 1,112 patients who underwent US-guided breast CNB with 14-gauge, 16-gauge and 18-gauge needles. Cases with surgical excision or a minimum of 2 years of imaging follow-up were included. Rates of sample inadequacy, discordance with surgical or imaging findings and upgrade of DCIS to invasive cancer or high-risk lesion to in situ or invasive cancer were computed for each needle size.
  
  
  RESULTS
  The study included 703 CNBs: 203 performed with 14-gauge, 235 with 16-gauge and 265 with 18-gauge needles. There were no significant differences between 14-gauge, 16-gauge and 18-gauge needles in rates of specimen inadequacy (0 %, 0.4 % and 1.9 %, respectively) (p = 0.084); surgical discordance (2.6 %, 2.9 % and 3.8 %) (p = 0.76); imaging discordance (0 %, 0 % and 2 %) (p = 1.0); DCIS upgrade (43 %, 43 % and 36 %) (p = 1.00) or high-risk lesion upgrade (38 %, 25 % and 55 %) (p = 0.49).
  
  
  CONCLUSIONS
  There was no statistically significant difference in diagnostic accuracy of US-guided CNB of breast masses performed with 14-gauge, 16-gauge and 18-gauge needles.
  
  
  CONCLUSIONS
  • Percutaneous image-guided breast core needle biopsy (CNB) is the standard of care. • Breast CNB with 14-gauge, 16-gauge and 18-gauge needles has similar diagnostic accuracy. • Smaller gauge needles can be confidently used for ultrasound-guided breast CNB.
authors.affiliation: The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Unit 1350, Houston, TX, 77030, USA. mlhuang@mdanderson.org.
authors.forename: Monica L
authors.initials: ML
authors.lastname: Huang
authors.affiliation: The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Unit 1350, Houston, TX, 77030, USA.
authors.forename: Kenneth
authors.initials: K
authors.lastname: Hess
authors.affiliation: The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Unit 1350, Houston, TX, 77030, USA.
authors.forename: Rosalind P
authors.initials: RP
authors.lastname: Candelaria
authors.affiliation: UC San Diego Health Sciences, 3855 Health Sciences Dr., #0846, La Jolla, CA, 92093-0846, USA.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Eghtedari
authors.affiliation: The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Unit 1350, Houston, TX, 77030, USA.
authors.forename: Beatriz E
authors.initials: BE
authors.lastname: Adrada
authors.affiliation: The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Unit 0085, Houston, TX, 77030, USA.
authors.forename: Nour
authors.initials: N
authors.lastname: Sneige
authors.affiliation: The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Unit 1350, Houston, TX, 77030, USA.
authors.forename: Bruno D
authors.initials: BD
authors.lastname: Fornage
mesh_terms: D062005:Biopsy, Large-Core Needle / Q000295:instrumentation*; D001707:Biopsy, Needle / Q000295:instrumentation*; D001940:Breast / Q000000981:diagnostic imaging*; D001943:Breast Neoplasms / Q000175:diagnosis*; D005260:Female; D006801:Humans; D061705:Image-Guided Biopsy / Q000379:methods*; D015203:Reproducibility of Results; D018084:Ultrasonography, Interventional / Q000379:methods*
keywords: Biopsy; Breast; Core; Needle; Ultrasound