title: Cardioprotective effects of omega 3 fatty acids: origin of the variability.
abstract: Since 40 years, it is known that omega-3 poly-unsaturated fatty acids (ω3 PUFAs) have cardioprotective effects. These include antiarrhythmic effects, improvements of autonomic function, endothelial function, platelet anti-aggregation and inflammatory properties, lowering blood pressure, plaque stabilization and reduced atherosclerosis. However, recently, conflicting results regarding the health benefits of ω3 PUFAs from seafood or ω3 PUFAs supplements have emerged. The aim of this review is to examine recent literature regarding health aspects of ω3 PUFAs intake from fish or supplements, and to discuss different arguments/reasons supporting these conflicting findings.
authors.affiliation: Inserm U1046 - UMR CNRS 9214 - PHYMEDEX, Université de Montpellier, Montpellier, France.
authors.forename: Jérôme
authors.initials: J
authors.lastname: Roy
authors.affiliation: Inserm U1046 - UMR CNRS 9214 - PHYMEDEX, Université de Montpellier, Montpellier, France. jean-yves.le-guennec@inserm.fr.|Inserm 1046 - UMR CNRS 9214 Physiologie et Médecine Expérimentale du Coeur et des Muscles, CHU Arnaud de Villeneuve, Bâtiment Crastes de Paulet 371 avenue du doyen Gaston Giraud, 34295, Montpellier Cedex 5, France. jean-yves.le-guennec@inserm.fr.
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Le Guennec
mesh_terms: D000818:Animals; D001145:Arrhythmias, Cardiac / Q000188:drug therapy / Q000517:prevention & control*; D015525:Fatty Acids, Omega-3 / Q000494:pharmacology / Q000627:therapeutic use*; D005399:Fishes; D006801:Humans
chemical_list: D015525:Fatty Acids, Omega-3
keywords: Cardiac arrhythmias; Controversies; Sarcomere proteins; ω-3 PUFA