title: Reactivation of Pulmonary Tuberculosis following Treatment of Myelofibrosis with Ruxolitinib.
abstract: Ruxolitinib is widely in use for treatment of myeloproliferative disorders. It causes inhibition of the Janus kinase (JAK) signal transducer and activation of transcription (STAT) pathway, which plays a key role in the underlying pathophysiology of myeloproliferative diseases. We describe a case of reactivation pulmonary tuberculosis in a retired physician while on treatment with ruxolitinib. We also review the literature on opportunistic infections following use of ruxolitinib. Our case highlights the importance of screening for latent tuberculosis in patients from highly endemic areas prior to start of therapy with ruxolitinib.
authors.affiliation: Division of Infectious Diseases, Department of Medicine, University of Colorado, Denver, CO, USA.
authors.forename: Maheen Z
authors.identifier: 0000-0002-0783-6535
authors.initials: MZ
authors.lastname: Abidi
authors.affiliation: Division of Infectious Diseases, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
authors.forename: Javeria
authors.initials: J
authors.lastname: Haque
authors.affiliation: University of Birmingham Medical School, Edgbaston, Birmingham, UK.
authors.forename: Parvathi
authors.initials: P
authors.lastname: Varma
authors.affiliation: Department of Pathology, Medical College of Wisconsin, Milwaukee, WI, USA.
authors.forename: Horatiu
authors.identifier: 0000-0001-5783-4485
authors.initials: H
authors.lastname: Olteanu
authors.affiliation: Division of Hematology and Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
authors.forename: Guru Subramanian
authors.initials: GS
authors.lastname: Guru Murthy
authors.affiliation: Division of Hematology and Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
authors.forename: Binod
authors.initials: B
authors.lastname: Dhakal
authors.affiliation: Division of Hematology and Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
authors.forename: Parameswaran
authors.initials: P
authors.lastname: Hari