title: Herpesvirus: an underestimated virus.
abstract: Herpes simplex virus (HSV) infections are common and widespread; nevertheless, their outcome can be of unpredictable prognosis in neonates and in immunosuppressed patients. Anti-HSV therapy is effective, but the emergence of drug-resistant strains or the drug toxicity that hamper the treatment is of great concern. Vaccine has not yet shown relevant benefit; therefore, palliative prophylactic measures have been adopted to prevent diseases. This short review proposes to present concisely the history of HSV, its taxonomy, physical structure, and replication and to explore the pathogenesis of the infection, clinical manifestations, laboratory diagnosis, treatment, prophylaxis and epidemiology of the diseases.
authors.affiliation: Departamento de Microbiologia, Laboratório de Virologia, Centro de Ciências Biológicas, Universidade Estadual de Londrina, Campus Universitário, Rod. Celso Garcia Cid, (Pr 445), km 380, Bairro: Jardim Portal de Versalhes, Londrina, Paraná, CEP: 86051-970, Brazil. daniele_zr@hotmail.com.
authors.forename: Daniele Zendrini
authors.identifier: http://orcid.org/0000-0002-9361-8517
authors.initials: DZ
authors.lastname: Rechenchoski
authors.affiliation: Departamento de Microbiologia, Laboratório de Virologia, Centro de Ciências Biológicas, Universidade Estadual de Londrina, Campus Universitário, Rod. Celso Garcia Cid, (Pr 445), km 380, Bairro: Jardim Portal de Versalhes, Londrina, Paraná, CEP: 86051-970, Brazil.
authors.forename: Ligia Carla
authors.initials: LC
authors.lastname: Faccin-Galhardi
authors.affiliation: Departamento de Microbiologia, Laboratório de Virologia, Centro de Ciências Biológicas, Universidade Estadual de Londrina, Campus Universitário, Rod. Celso Garcia Cid, (Pr 445), km 380, Bairro: Jardim Portal de Versalhes, Londrina, Paraná, CEP: 86051-970, Brazil.
authors.forename: Rosa Elisa Carvalho
authors.initials: REC
authors.lastname: Linhares
authors.affiliation: Departamento de Microbiologia, Laboratório de Virologia, Centro de Ciências Biológicas, Universidade Estadual de Londrina, Campus Universitário, Rod. Celso Garcia Cid, (Pr 445), km 380, Bairro: Jardim Portal de Versalhes, Londrina, Paraná, CEP: 86051-970, Brazil.
authors.forename: Carlos
authors.initials: C
authors.lastname: Nozawa
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use*; D006558:Herpes Genitalis / Q000175:diagnosis / Q000188:drug therapy* / Q000453:epidemiology / Q000276:immunology; D006561:Herpes Simplex / Q000175:diagnosis / Q000188:drug therapy* / Q000453:epidemiology / Q000276:immunology; D018259:Herpesvirus 1, Human / Q000145:classification / Q000187:drug effects / Q000254:growth & development / Q000472:pathogenicity*; D018258:Herpesvirus 2, Human / Q000145:classification / Q000187:drug effects / Q000254:growth & development / Q000472:pathogenicity*; D006801:Humans; D016867:Immunocompromised Host; D007231:Infant, Newborn; D014779:Virus Replication / Q000187:drug effects / Q000235:genetics
chemical_list: D000998:Antiviral Agents