title: Sustained Lung Inflation: Physiology and Practice.
abstract: Lung aeration is the most critical task newborns must accomplish after birth. Almost all extremely preterm infants require respiratory support during this process, but the best method to promote lung aeration in preterm infants is unknown. The current standard practice is intermittent positive pressure ventilation with positive end-expiratory pressure. Sustained inflation is a promising alternative strategy for lung liquid clearance and aeration. Here we review the physiologic rationale for sustained inflation and the available clinical evidence for sustained inflation in preterm infants.
authors.affiliation: Division of Neonatology, The Children's Hospital of Philadelphia, The Hospital of the University of Pennsylvania, The University of Pennsylvania Perelman School of Medicine, 8th Floor Ravdin Building, 3400 Spruce Street, Philadelphia, PA 19104, USA. Electronic address: foglia@email.chop.edu.
authors.forename: Elizabeth E
authors.initials: EE
authors.lastname: Foglia
authors.affiliation: Division of Neonatology, Department of Pediatrics, Leiden University Medical Center, Albinusdreef 2, 2300 RC, Leiden, Netherlands.
authors.forename: Arjan B
authors.initials: AB
authors.lastname: Te Pas
mesh_terms: D001997:Bronchopulmonary Dysplasia / Q000453:epidemiology; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007385:Intermittent Positive-Pressure Ventilation / Q000379:methods*; D008168:Lung / Q000502:physiology* / Q000503:physiopathology; D011175:Positive-Pressure Respiration / Q000379:methods; D012127:Respiratory Distress Syndrome, Newborn / Q000628:therapy*; D012143:Respiratory Physiological Phenomena
keywords: Bronchopulmonary dysplasia; Lung aeration; Preterm; Sustained inflation