title: Identification of the stria medullaris thalami using diffusion tensor imaging.
abstract: Deep brain stimulation (DBS) via anatomical targeting of white matter tracts defined by diffusion tensor imaging (DTI) may be a useful tool in the treatment of pathologic neurophysiologic circuits implicated in certain disease states like treatment resistant depression (TRD). We sought to determine if DTI could be used to define the stria medullaris thalami (SM), the major afferent white matter pathway to the lateral habenula (LHb), a thalamic nucleus implicated in the pathophysiology of TRD.
  
  
  
  Probabilistic DTI was performed on ten cerebral hemispheres in five patients who underwent preoperative MRI for DBS surgery. Manual identification of the LHb on axial T1 weighted MRI was used for the initial seed region for tractography. Variations in tractography depending on chosen axial slice of the LHb and chosen voxel within the LHb were also assessed.
  
  
  
  In all hemispheres the SM was reliably visualized. Variations in chosen axial seed slice as well as variations in single seed placement did not lead to significant changes in SM tractography.
  
  
  
  Probabilistic DTI can be used to visualize the SM which may ultimately provide utility for direct anatomic targeting in DBS surgery.
authors.affiliation: Department of Neurosurgery, Rush University Medical Center, 1725 W. Harrison St, Suite 855, Chicago, IL 60612, United States.
authors.forename: Ryan B
authors.initials: RB
authors.lastname: Kochanski
authors.affiliation: Rush Alzheimer's Disease Center, 600 S Paulina St, Chicago, IL 60612, United States; Johnston R Bowman Health Center, 600 S Paulina St, Chicago, IL 60612, United States.
authors.forename: Robert
authors.initials: R
authors.lastname: Dawe
authors.affiliation: Department of Neurosurgery, Rush University Medical Center, 1725 W. Harrison St, Suite 855, Chicago, IL 60612, United States.
authors.forename: Daniel B
authors.initials: DB
authors.lastname: Eddelman
authors.affiliation: Department of Radiology, Rush University Medical Center, 1725 W. Harrison St, Suite 437, Chicago, IL 60612, United States.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Kocak
authors.affiliation: Department of Neurosurgery, Rush University Medical Center, 1725 W. Harrison St, Suite 855, Chicago, IL 60612, United States.
authors.forename: Sepehr
authors.initials: S
authors.lastname: Sani
mesh_terms: D000344:Afferent Pathways / Q000000981:diagnostic imaging*; D046690:Deep Brain Stimulation; D056324:Diffusion Tensor Imaging / Q000379:methods*; D019261:Epithalamus / Q000000981:diagnostic imaging*; D019262:Habenula / Q000000981:diagnostic imaging; D006801:Humans; D010300:Parkinson Disease / Q000000981:diagnostic imaging* / Q000628:therapy; D013788:Thalamus / Q000000981:diagnostic imaging*
keywords: Deep brain stimulation (DBS); Depression; Diffusion tensor imaging (DTI); Stria medullaris (SM)