title: Systemic Therapies for Late-stage Melanoma.
abstract: Late-stage melanoma is associated with high morbidity and mortality. Classic treatment methods relied on cytotoxic chemotherapy, which is limited by low response rates and significant adverse effects. Recent advances in immunogenetics have led to the advent of important new systemictreatments.Thisarticle reviews the latest therapy options for advanced melanoma.
authors.affiliation: Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York.
authors.forename: Peter W
authors.initials: PW
authors.lastname: Hashim
authors.affiliation: Division of Hematology and Oncology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai,New York, New York.
authors.forename: Philip
authors.initials: P
authors.lastname: Friedlander
authors.affiliation: Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York.
authors.forename: Gary
authors.initials: G
authors.lastname: Goldenberg