title: Hypertension in blacks: insights from Africa.
abstract: Although the consequences of hypertension are universal, blacks (African-Americans or indigenous Africans) have been the subject of a differential approach to causation, outcome, and treatment. Blacks have a greater propensity to salt sensitivity and suppressed plasma renin suggesting a predisposition to sodium retention. Target organ damage is more frequent and blood pressure is more difficult to control. We explore potential underlying causes, both genetic and environmental, particularly in the South African population, and propose a more physiological approach to the treatment of resistant hypertension in blacks.
authors.affiliation: aDivision of Nephrology and Hypertension, University of Cape Town, Cape Town, South Africa bStroke Prevention and Atherosclerosis Research Centre, Robarts Research Institute, Western University, London, Ontario, Canada.
authors.forename: Brian L
authors.initials: BL
authors.lastname: Rayner
authors.forename: J David
authors.initials: JD
authors.lastname: Spence
mesh_terms: D001741:Black or African American; D001794:Blood Pressure / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000208:ethnology* / Q000235:genetics* / Q000503:physiopathology; D012083:Renin / Q000097:blood*; D017673:Sodium Chloride, Dietary / Q000378:metabolism; D013019:South Africa; D044465:White People
chemical_list: D017673:Sodium Chloride, Dietary; D012083:Renin