title: T2 Fluid-Attenuated Inversion Recovery Imaging of Uveal Melanomas and Other Ocular Pathology.
abstract: OBJECTIVE
  This study describes patterns of intraocular lesions on T2 fluid-attenuated inversion recovery (FLAIR) imaging, exploring a prospective role of FLAIR imaging sequence in diagnosis and treatment.
  
  
  METHODS
  A retrospective study of orbital magnetic resonance imaging (MRI) studies from the years 2000 to 2015 was performed. MRI sequences included: pre-contrast T1-weighted, T2-weighted, T2 FLAIR, and postcontrast T1 and T2 imaging gadolinium, which were evaluated by a neuroradiologist. Two cases of melanoma were correlated to their pathology.
  
  
  RESULTS
  Twenty-four patients with intraocular pathology were evaluated. All lesions, regardless of pigmentation, revealed previously described melanotic patterns on T1- and T2-weighted images; 80% of 10 melanomas localized were hyperintense on T2 FLAIR, which better delineated lesion margins. All of the four inflammatory pathologies on T2 FLAIR were hyperintense, as were 80% of the amelanotic neoplasms. Pathology of two large uveal melanomas paralleled the findings seen on T2 FLAIR.
  
  
  CONCLUSIONS
  T2 FLAIR appears beneficial in the demarcation of pigmented ocular lesions and may aid in determining protein content or previous treatment. Data also promote previous assertions that blood flow impacts intensity of lesions on T2 FLAIR. Further research is warranted.
authors.affiliation: Department of Ophthalmology, Mayo Clinic, Rochester, Minn., USA.
authors.forename: Gena M
authors.initials: GM
authors.lastname: Damento
authors.affiliation: Department of Radiology, Mayo Clinic, Rochester, Minn., USA.
authors.forename: Kelly K
authors.initials: KK
authors.lastname: Koeller
authors.affiliation: Department of Anatomic Pathology, Mayo Clinic, Rochester, Minn., USA.
authors.forename: Diva R
authors.initials: DR
authors.lastname: Salomão
authors.affiliation: Department of Ophthalmology, Mayo Clinic, Rochester, Minn., USA; Department of Molecular Medicine, Mayo Clinic, Rochester, Minn., USA.
authors.forename: Jose S
authors.initials: JS
authors.lastname: Pulido
keywords: Choroidal hemangioma; Magnetic resonance imaging; Melanoma; Posttreatment changes; T2 fluid-attenuated inversion recovery; Uveal melanoma