title: Memory Upgrade: Insights into Primed Adaptation by CRISPR-Cas Immune Systems.
abstract: Recently, Künne et al. (2016) demonstrated that degradation products of Cas3 obtained during CRISPR interference fuel priming. In this issue of Molecular Cell, Xue et al. (2016) highlight the conformational changes in Cascade that underpin the priming process when interference is blocked.
authors.affiliation: Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.
authors.forename: Anita
authors.initials: A
authors.lastname: Ramachandran
authors.affiliation: Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA; Department of Biophysics and Biophysical Chemistry, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA. Electronic address: scott.bailey@jhu.edu.
authors.forename: Scott
authors.initials: S
authors.lastname: Bailey
mesh_terms: D000222:Adaptation, Physiological; D064130:CRISPR-Associated Proteins / Q000235:genetics*; D064113:CRISPR-Cas Systems; D064112:Clustered Regularly Interspaced Short Palindromic Repeats; D007107:Immune System
chemical_list: D064130:CRISPR-Associated Proteins