title: Patient-Oriented Eczema Measure (POEM), a core instrument to measure symptoms in clinical trials: a Harmonising Outcome Measures for Eczema (HOME) statement.
abstract: BACKGROUND
  The Harmonising Outcome Measures for Eczema (HOME) initiative has defined four core outcome domains for a core outcome set (COS) to be measured in all atopic eczema (AE) trials to ensure cross-trial comparison: clinical signs, symptoms, quality of life and long-term control.
  
  
  OBJECTIVE
  The aim of this paper is to report on the consensus process that was used to select the core instrument to consistently assess symptoms in all future AE trials.
  
  
  METHODS
  Following the HOME roadmap, two systematic reviews were performed which identified three instruments that had sufficient evidence of validity, reliability and feasibility to be considered for the final COS.
  
  
  RESULTS
  At the fourth international HOME meeting, there was broad consensus among all stakeholders that the Patient-Oriented Eczema Measure (POEM) should be used as the core instrument (87·5% agreed, 9·4% unsure, 3·1% disagreed).
  
  
  CONCLUSIONS
  All relevant stakeholders are encouraged to use POEM as the chosen instrument to measure the core domain of symptoms in all future AE clinical trials. Other instruments of interest can be used in addition to POEM.
authors.affiliation: Department of Dermatology, Academic Medical Centre, University of Amsterdam, Amsterdam, the Netherlands.
authors.forename: P I
authors.identifier: http://orcid.org/0000-0002-6035-2863
authors.initials: PI
authors.lastname: Spuls
authors.affiliation: Department of Dermatology, Academic Medical Centre, University of Amsterdam, Amsterdam, the Netherlands.
authors.forename: L A A
authors.identifier: http://orcid.org/0000-0002-5244-5058
authors.initials: LAA
authors.lastname: Gerbens
authors.affiliation: Department of Dermatology, Oregon Health & Sciences University, Portland, OR, U.S.A.
authors.forename: E
authors.initials: E
authors.lastname: Simpson
authors.affiliation: Medical Sociology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany.
authors.forename: C J
authors.identifier: http://orcid.org/0000-0003-3805-8219
authors.initials: CJ
authors.lastname: Apfelbacher
authors.affiliation: Centre of Evidence Based Dermatology, University of Nottingham, Nottingham, U.K.
authors.forename: J R
authors.initials: JR
authors.lastname: Chalmers
authors.affiliation: Centre of Evidence Based Dermatology, University of Nottingham, Nottingham, U.K.
authors.forename: K S
authors.identifier: http://orcid.org/0000-0001-7785-7465
authors.initials: KS
authors.lastname: Thomas
authors.affiliation: Department of Epidemiology and Biostatistics, EMGO+ Institute for Health and Care Research, VU University Medical Center, Amsterdam, the Netherlands.
authors.forename: C A C
authors.initials: CAC
authors.lastname: Prinsen
authors.affiliation: Institution for Clinical Science, Department of Dermatology, Lund University, Malmö, Sweden.
authors.forename: L B
authors.initials: LB
authors.lastname: von Kobyletzki
authors.affiliation: Department of Rheumatology and Division of Epidemiology, University of Alabama, Birmingham, AL, U.S.A.|Veterans Affairs Medical Center, Birmingham, AL, U.S.A.|Mayo Clinic College of Medicine, Rochester, MN, U.S.A.
authors.forename: J A
authors.initials: JA
authors.lastname: Singh
authors.affiliation: Centre of Evidence Based Dermatology, University of Nottingham, Nottingham, U.K.
authors.forename: H C
authors.initials: HC
authors.lastname: Williams
authors.affiliation: Centre for Evidence-based Healthcare, University Hospital Carl Gustav Carus, TU, Dresden, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Schmitt
mesh_terms: D002986:Clinical Trials as Topic; D032921:Consensus; D003876:Dermatitis, Atopic / Q000175:diagnosis*; D005240:Feasibility Studies; D005544:Forecasting; D006801:Humans; D000071066:Patient Reported Outcome Measures; D011537:Pruritus / Q000175:diagnosis; D015203:Reproducibility of Results; D012720:Severity of Illness Index