title: Construction and Validation of a Multi-Institutional Tissue Microarray of Invasive Ductal Carcinoma From Racially and Ethnically Diverse Populations.
abstract: BACKGROUND
  The scarcity of tissues from racial and ethnic minorities at biobanks poses a scientific constraint to research addressing health disparities in minority populations.
  
  
  METHODS
  To address this gap, the Minority Biospecimen/Biobanking Geographic Management Program for region 3 (BMaP-3) established a working infrastructure for a "biobanking" hub in the southeastern United States and Puerto Rico. Herein we describe the steps taken to build this infrastructure, evaluate the feasibility of collecting formalin-fixed, paraffin-embedded tissue blocks and associated data from a single cancer type (breast), and create a web-based database and tissue microarrays (TMAs).
  
  
  RESULTS
  Cancer registry data from 6 partner institutions were collected, representing 12,408 entries from 8,279 unique patients with breast cancer (years 2001-2011). Data were harmonized and merged, and deidentified information was made available online. A TMA was constructed from formalin-fixed, paraffin-embedded samples of invasive ductal carcinoma (IDC) representing 427 patients with breast cancer (147 African Americans, 168 Hispanics, and 112 non-Hispanic whites) and was annotated according to biomarker status and race/ethnicity. Biomarker analysis of the TMA was consistent with the literature.
  
  
  CONCLUSIONS
  Contributions from participating institutions have facilitated a robust research tool. TMAs of IDC have now been released for 5 projects at 5 different institutions.
authors.affiliation: Tumor Biology Program, Moffitt Cancer Center, Tampa, FL, USA. Teresita.Antonia@Moffitt.org.
authors.forename: Edward
authors.initials: E
authors.lastname: Seijo
authors.forename: Diana
authors.initials: D
authors.lastname: Lima
authors.forename: Egiebade
authors.initials: E
authors.lastname: Iriabho
authors.forename: Jonas
authors.initials: J
authors.lastname: Almeida
authors.forename: Jesus
authors.initials: J
authors.lastname: Monico
authors.forename: Margarita
authors.initials: M
authors.lastname: Echeverri
authors.forename: Sylvia
authors.initials: S
authors.lastname: Gutierrez
authors.forename: Idhaliz
authors.initials: I
authors.lastname: Flores
authors.forename: Ji-Hyun
authors.initials: JH
authors.lastname: Lee
authors.forename: Kate
authors.initials: K
authors.lastname: Fisher
authors.forename: William E
authors.initials: WE
authors.lastname: Grizzle
authors.forename: Gabriel L
authors.initials: GL
authors.lastname: Sica
authors.forename: Charles
authors.initials: C
authors.lastname: Butler
authors.forename: Chindo
authors.initials: C
authors.lastname: Hicks
authors.forename: Cathy D
authors.initials: CD
authors.lastname: Meade
authors.forename: Stephen Olufemi
authors.initials: SO
authors.lastname: Sodeke
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Moroz
authors.forename: Domenico
authors.initials: D
authors.lastname: Coppola
authors.forename: Teresita
authors.initials: T
authors.lastname: Munoz-Antonia
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018270:Carcinoma, Ductal, Breast / Q000453:epidemiology*; D005006:Ethnicity; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D046888:Tissue Array Analysis