title: Post-Stroke Fatigue May Be Associated with the Promoter Region of a Monoamine Oxidase A Gene Polymorphism.
abstract: Post-stroke fatigue (PSF) is a common sequela of stroke. Despite reports of serotonergic involvement in the etiology of PSF, the potential contribution of serotonergic genes in the development of PSF needs to be investigated.
  
  
  
  A total of 373 patients, who experienced ischemic stroke for PSF, were evaluated 3 months after the stroke. PSF was assessed using the Fatigue Severity Scale. The genomic DNA collected and stored in a -70°C freezer was genotyped for 6 polymorphisms in genes associated with serotonin synthesis (tryptophan hydroxylase 1 (TPH1) A218C, TPH2 rs10879355, and TPH2 rs4641528), transport (the promoter region of the serotonin transporter protein), and catabolism (the 30-bp functional variable number tandem repeat) polymorphism in the promoter region of monoamine oxidase A (MAO-A).
  
  
  
  Among the 373 patients, 164 (44%) had PSF. All patients were ethnic Koreans. Of the 6 polymorphisms examined, only one marker, that is, low-activity MAO-A was associated with PSF (p < 0.05) in female patients. Multiple logistic regression analyses showed that post-stroke depression (PSD; 95% CI 1.561-14.323, p = 0.006) and low MAO-A activity (95% CI 0.166-0.722, p = 0.005) were factors associated with PSF in female patients, whereas only PSD (95% CI 5.511-65.269, p = 0.000) was associated with PSF in male patients.
  
  
  
  Our findings suggest that PSF may be associated with a genetic polymorphism involving MAO-A, at least in female stroke patients.
authors.affiliation: College of Nursing, The Research Institute of Nursing Science, eoul National University, Seoul, South Korea.
authors.forename: Smi
authors.initials: S
authors.lastname: Choi-Kwon
authors.forename: Mihye
authors.initials: M
authors.lastname: Ko
authors.forename: Sang-Eun
authors.initials: SE
authors.lastname: Jun
authors.forename: Juhan
authors.initials: J
authors.lastname: Kim
authors.forename: Kyung-Hee
authors.initials: KH
authors.lastname: Cho
authors.forename: Hyun-Wook
authors.initials: HW
authors.lastname: Nah
authors.forename: Hasup
authors.initials: H
authors.lastname: Song
authors.forename: Jong S
authors.initials: JS
authors.lastname: Kim
mesh_terms: D016009:Chi-Square Distribution; D005221:Fatigue / Q000175:diagnosis / Q000201:enzymology / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D008995:Monoamine Oxidase / Q000235:genetics*; D015999:Multivariate Analysis; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D056910:Republic of Korea; D012307:Risk Factors; D012737:Sex Factors; D020521:Stroke / Q000150:complications* / Q000175:diagnosis
chemical_list: D008995:Monoamine Oxidase; C579458:monoamine oxidase A, human