title: Oxytocin Receptor(OXTR)Methylation and Cognition in Psychotic Disorders.
abstract: Previous reports have identified an association between cognitive impairment and genetic variation in psychotic disorders. In particular, this association may be related to abnormal regulation of genes responsible for broad cognitive functions such as the oxytocin receptor(OXTR). Within psychotic disorders, it is unknown ifOXTRmethylation, which can have important implications for gene regulation, is related to cognitive function. The current study examined peripheral bloodOXTRmethylation and general cognition in people with schizophrenia, schizoaffective disorder, and psychotic disorder not otherwise specified (N = 101). Using hierarchical multiple regression analysis, methylation at the Chr3:8767638 site was significantly associated with composite cognitive performance independent of demographic and medication factors while controlling for multiple testing in this combined diagnostic sample (adjusted p = 0.023).
authors.affiliation: Department of Psychology, University of Michigan, Ann Arbor, Mich., USA.
authors.forename: Tyler B
authors.initials: TB
authors.lastname: Grove
authors.affiliation: Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Mich., USA.
authors.forename: Kyle J
authors.initials: KJ
authors.lastname: Burghardt
authors.affiliation: Department of Psychology, University of Michigan, Ann Arbor, Mich., USA.
authors.forename: A Zarina
authors.initials: AZ
authors.lastname: Kraal
authors.affiliation: Luskin School of Public Affairs, University of California, Los Angeles, Los Angeles, Calif.,USA.
authors.forename: Ryan J
authors.initials: RJ
authors.lastname: Dougherty
authors.affiliation: Department of Psychology, University of Michigan, Ann Arbor, Mich., USA; Department of Psychiatry, University of Michigan, Ann Arbor, Mich., USA.
authors.forename: Stephan F
authors.initials: SF
authors.lastname: Taylor
authors.affiliation: Department of Psychology, University of Michigan, Ann Arbor, Mich., USA; Department of Psychiatry, University of Michigan, Ann Arbor, Mich., USA; College of Pharmacy, University of Michigan, Ann Arbor, Mich., USA.
authors.forename: Vicki L
authors.initials: VL
authors.lastname: Ellingrod
keywords: Cognition; Methylation; Oxytocin receptor; Psychosis