title: Central Neurocytoma: A Review of Clinical Management and Histopathologic Features.
abstract: Central neurocytoma (CN) is a rare, benign brain tumor often located in the lateral ventricles. CN may cause obstructive hydrocephalus and manifest as signs of increased intracranial pressure. The goal of treatment for CN is a gross total resection (GTR), which often yields excellent prognosis with a very high rate of tumor control and survival. Adjuvant radiosurgery and radiotherapy may be considered to improve tumor control when GTR cannot be achieved. Chemotherapy is also not considered a primary treatment, but has been used as a salvage therapy. The radiological features of CN are indistinguishable from those of other brain tumors; therefore, many histological markers, such as synaptophysin, can be very useful for diagnosing CNs. Furthermore, the MIB-1 Labeling Index seems to be correlated with the prognosis of CN. We also discuss oncogenes associated with these elusive tumors. Further studies may improve our ability to accurately diagnose CNs and to design the optimal treatment regimens for patients with CNs.
authors.affiliation: Department of Neurosurgery, University of California, Los Angeles, Los Angeles, CA, USA.
authors.forename: Seung J
authors.initials: SJ
authors.lastname: Lee
authors.affiliation: Department of Neurosurgery, University of California, Los Angeles, Los Angeles, CA, USA.
authors.forename: Timothy T
authors.initials: TT
authors.lastname: Bui
authors.affiliation: Department of Neurosurgery, University of California, Los Angeles, Los Angeles, CA, USA.
authors.forename: Cheng Hao Jacky
authors.initials: CH
authors.lastname: Chen
authors.affiliation: Department of Neurosurgery, University of California, Los Angeles, Los Angeles, CA, USA.
authors.forename: Carlito
authors.initials: C
authors.lastname: Lagman
authors.affiliation: Department of Neurosurgery, University of California, Los Angeles, Los Angeles, CA, USA.
authors.forename: Lawrance K
authors.initials: LK
authors.lastname: Chung
authors.affiliation: Department of Neurosurgery, University of California, Los Angeles, Los Angeles, CA, USA.
authors.forename: Sabrin
authors.initials: S
authors.lastname: Sidhu
authors.affiliation: Department of Neurosurgery, University of California, Los Angeles, Los Angeles, CA, USA.
authors.forename: David J
authors.initials: DJ
authors.lastname: Seo
authors.affiliation: Department of Pathology & Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
authors.forename: William H
authors.initials: WH
authors.lastname: Yong
authors.affiliation: Department of Radiology, Division of Neuroradiology, Cooper University Hospital, Camden, NJ, USA.
authors.forename: Todd L
authors.initials: TL
authors.lastname: Siegal
authors.affiliation: Department of Neurosurgery, Yeungnam University College of Medicine, Daegu, Korea.
authors.forename: Minsu
authors.initials: M
authors.lastname: Kim
authors.affiliation: Department of Neurosurgery, University of California, Los Angeles, Los Angeles, CA, USA.; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA, USA.
authors.forename: Isaac
authors.initials: I
authors.lastname: Yang
keywords: Central neurocytoma; Histopathology; Management