title: Effects of initial telomere length distribution on senescence onset and heterogeneity.
abstract: Replicative senescence, induced by telomere shortening, exhibits considerable asynchrony and heterogeneity, the origins of which remain unclear. Here, we formally study how telomere shortening mechanisms impact on senescence kinetics and define two regimes of senescence, depending on the initial telomere length variance. We provide analytical solutions to the model, highlighting a non-linear relationship between senescence onset and initial telomere length distribution. This study reveals the complexity of the collective behavior of telomeres as they shorten, leading to senescence heterogeneity.
authors.affiliation: Sorbonne Universités, UPMC Université Pierre et Marie Curie, UMR 7598, Laboratoire Jacques-Louis Lions, F-75005 Paris, France; INRIA Paris, 2 rue Simone Iff, F-75012 Paris, France. Electronic address: Sarah.Eugene@inria.fr.
authors.forename: Sarah
authors.initials: S
authors.lastname: Eugène
authors.affiliation: École Normale Supérieure de Lyon, UMR 5569, Unité de Mathématiques Pures et Appliquées, 69007 Lyon, France; INRIA Numed, 46 allée d'Italie, 69007 Lyon, France. Electronic address: thibault.bourgeron@ens-lyon.fr.
authors.forename: Thibault
authors.initials: T
authors.lastname: Bourgeron
authors.affiliation: Sorbonne Universités, UPMC Univ Paris 06, CNRS, UMR 8226, Laboratoire de Biologie Moléculaire et Cellulaire des Eucaryotes, Institut de Biologie Physico-Chimique, 75005 Paris, France. Electronic address: zhou.xu@ibpc.fr.
authors.forename: Zhou
authors.initials: Z
authors.lastname: Xu
mesh_terms: D016922:Cellular Senescence; D003198:Computer Simulation; D004261:DNA Replication; D019143:Evolution, Molecular; D009716:Numerical Analysis, Computer-Assisted; D019098:Telomerase / Q000378:metabolism; D016615:Telomere / Q000378:metabolism*; D059505:Telomere Homeostasis
chemical_list: D019098:Telomerase
keywords: Replicative senescence; Stochastic model; Telomerase; Telomere; Yeast