title: Efficacy of Nepeta Menthoides Boiss and Buhse Freeze-Dried Aqueous Extract on Anxiety of Patients with Depression: A Double-Blind Randomized Controlled Clinical Trial.
abstract: BACKGROUND
  The efficacy and safety of Nepeta menthoides freeze-dried aqueous extract were assessed on the anxiety of patients suffering from depression.
  
  
  METHODS
  Patients received either N. menthoides formulation (400 mg/BID) or Sertraline (50 mg/BID) for 4 weeks. The Beck Anxiety Inventory (BAI) scales were used to assess the anxiety in two-week intervals (2nd, 4th, and 6thweeks). Folin-Ciocalteu and Dowd methods were used to determine the formulation of total phenol and flavonoid contents.
  
  
  RESULTS
  Compared with Sertraline, N. menthoides showed a higher reduction in BAI scores in the 2nd(16.52±8.07 vs. 21.38±10.98, P<0.05) and 4thweek (11.55±6.74 vs. 20.47±11.53, P<0.05) along with a reduction in the recurrence rate and side effects. Total phenolic and flavonoid contents revealed in the presence of 127.09±0.43 mg GAE/g and 16.93±0.09 mg Q/g of extract.
  
  
  CONCLUSIONS
  N. menthoides could be effective in the control and introducing a delay in recurrence of anxiety in patients with depression.
authors.affiliation: Research Center for Psychiatry and Behavioural Sciences, Department of Psychiatry, School of Medicine, Hafiz Hospital, Shiraz, University of Medical Sciences, Shiraz, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Firoozabadi
authors.affiliation: Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; Department of Traditional Persian Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Sepideh
authors.initials: S
authors.lastname: Kolouri
authors.affiliation: Medicinal Plants Processing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; Department of Phytopharmaceuticals (Traditional Pharmacy), School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Mohammad M
authors.initials: MM
authors.lastname: Zarshenas
authors.affiliation: Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; Department of Traditional Persian Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Alireza
authors.initials: A
authors.lastname: Salehi
authors.affiliation: Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Seyed Hamdollah
authors.initials: SH
authors.lastname: Mosavat
authors.affiliation: Substance Abuse Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Seyed Ali
authors.initials: SA
authors.lastname: Dastgheib
keywords: Anxiety; Depression; Herbal medicine; Medicine; Traditional