title: The efficacy of intradermal injection of type A botulinum toxin for facial rejuvenation.
abstract: The aim of this study is to evaluate the efficacy for effectiveness of type A botulinum toxin intradermal injection for facial rejuvenation. Forty female subjects were randomly divided into two groups: BoNTA group and control group. In BoNTA group, each subject's facial skin was treated with intradermal injection of BoNTA, and subjects of the control group were treated with intradermal saline solution injection. Subjects receiving one session of treatment and evaluations were conducted at baseline, four weeks, and twelve weeks after treatment. The outcome assessments included subjective satisfaction scale; blinded clinical assessment; and the biophysical parameters of roughness, elasticity, skin hydration, transepidermal water loss (TEWL), erythema, and melanin index. BoNTA group showed higher physician's global assessment score, subject satisfaction score, roughness, skin hydration, skin elasticity, and lower TEWL compared to that of control group at 12 weeks post-treatment. No significant difference was found among erythema and melanin index at baseline, four, and twelve weeks after treatment among the two major groups. In conclusion, intradermal BoNTA injection can be considered as an effective method for facial rejuvenation.
authors.affiliation: Department of Dermatology, Affiliated Hospital of Nanjing University of TCM, Nanjing, Jiangsu, 210029, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Zhu
authors.affiliation: Department of Dermatology, Nanjing Maternal and Child Health Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu, 210029, China.
authors.forename: Xi
authors.initials: X
authors.lastname: Ji
authors.affiliation: Department of Dermatology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Department of Dermatology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Dermatology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
authors.forename: Ying-Ying
authors.initials: YY
authors.lastname: Miao
authors.affiliation: Department of Dermatology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
authors.forename: Jia-An
authors.initials: JA
authors.lastname: Zhang
authors.affiliation: Department of Dermatology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Luo
authors.affiliation: Department of Dermatology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
authors.forename: Bing-Rong
authors.initials: BR
authors.lastname: Zhou
mesh_terms: D065087:Acetylcholine Release Inhibitors / Q000008:administration & dosage* / Q000009:adverse effects; D000328:Adult; D000368:Aged; D019274:Botulinum Toxins, Type A / Q000008:administration & dosage* / Q000009:adverse effects; D002681:China; D003357:Cosmetic Techniques / Q000009:adverse effects; D005260:Female; D006801:Humans; D007271:Injections, Intradermal; D008875:Middle Aged; D017060:Patient Satisfaction; D010781:Photography; D012060:Rejuvenation; D015595:Skin Aging; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D065087:Acetylcholine Release Inhibitors; D019274:Botulinum Toxins, Type A
keywords: BoNTA; facial rejuvenation; intradermal injection