title: Sugammadex given for rocuronium-induced neuromuscular blockade in infants: a retrospectıve study.
abstract: OBJECTIVE
  To evaluate the efficacy and safety of sugammadex in reversing profound neuromuscular block induced by rocuronium in infant patients.
  
  
  METHODS
  Retrospective observational study.
  
  
  METHODS
  University teaching hospital.
  
  
  METHODS
  Twenty-six infants (2-12 months of age; 3-11 kg) with an American Society of Anesthesiologists classification I, II, or III who were scheduled to undergo neurosurgical procedures were included in the study.
  
  
  METHODS
  Anesthesia was induced with 5 mg/kg thiopental, 1 μg/kg fentanyl and 0.6 mg/kg rocuronium. Sevoflurane was administered to all patients after intubation.
  
  
  METHODS
  The neuromuscular block was monitored with acceleromyography using train-of-four (TOF) stimuli. Patients received additional doses of rocuronium to maintain a deep block during surgery. If profound neuromuscular block (TOF, 0) persisted at the end of the surgery, 3mg/kg sugammadex was administered.
  
  
  METHODS
  The demographic data, surgeries, and anesthetic agents were recorded. The time from sugammadex administration to recovery of neuromuscular function (TOF ratio, >0.9) and complications during and after extubation were also recorded.
  
  
  RESULTS
  Twenty-six infants who had a deep neuromuscular block (TOF, 0) at the end of surgery received 3 mg/kg sugammadex. The mean recovery time of the T4/T1 ratio of 0.9 was 112 seconds. No clinical evidence of recurarization or residual curarization was observed.
  
  
  CONCLUSIONS
  The efficacy and safety of sugammadex were confirmed in infant surgical patients for reversal of deep neuromuscular block induced by rocuronium.
authors.affiliation: Anesthesiology and Reanimation Department, Baskent University School of Medicine, Adana, Turkey. Electronic address: ozlemyilma@yahoo.com.
authors.forename: Ozlem
authors.initials: O
authors.lastname: Ozmete
authors.affiliation: Anesthesiology and Reanimation Department, Baskent University School of Medicine, Adana, Turkey. Electronic address: caglaetike@hotmail.com.
authors.forename: Cagla
authors.initials: C
authors.lastname: Bali
authors.affiliation: Anesthesiology and Reanimation Department, Baskent University School of Medicine, Adana, Turkey. Electronic address: oyacok01@yahoo.com.
authors.forename: Oya Yalcin
authors.initials: OY
authors.lastname: Cok
authors.affiliation: Anesthesiology and Reanimation Department, Baskent University School of Medicine, Adana, Turkey. Electronic address: evreneker@yahoo.com.
authors.forename: Hatice Evren Eker
authors.initials: HE
authors.lastname: Turk
authors.affiliation: Anesthesiology and Reanimation Department, Baskent University School of Medicine, Adana, Turkey. Electronic address: nesrinbozdogan@yahoo.com.
authors.forename: Nesrın Bozdogan
authors.initials: NB
authors.lastname: Ozyilkan
authors.affiliation: Neurosurgery Department, Baskent University School of Medicine, Adana, Turkey. Electronic address: sonercivi@yahoo.com.
authors.forename: Soner
authors.initials: S
authors.lastname: Civi
authors.affiliation: Anesthesiology and Reanimation Department, Baskent University School of Medicine, Adana, Turkey; Neurosurgery Department, Baskent University School of Medicine, Adana, Turkey. Electronic address: aaribogan@yahoo.com.
authors.forename: Anıs
authors.initials: A
authors.lastname: Aribogan
mesh_terms: D000732:Androstanols / Q000037:antagonists & inhibitors*; D000762:Anesthesia Recovery Period; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D019148:Neuromuscular Blockade; D003473:Neuromuscular Nondepolarizing Agents / Q000037:antagonists & inhibitors*; D012189:Retrospective Studies; D000077123:Rocuronium; D000077122:Sugammadex; D016896:Treatment Outcome; D047408:gamma-Cyclodextrins / Q000494:pharmacology*
chemical_list: D000732:Androstanols; D003473:Neuromuscular Nondepolarizing Agents; D047408:gamma-Cyclodextrins; D000077122:Sugammadex; D000077123:Rocuronium
keywords: Infant; Neurosurgery; Rocuronium; Sugammadex