title: Effects of T208E activating mutation on MARK2 protein structure and dynamics: Modeling and simulation.
abstract: Microtubule Affinity-Regulating Kinase 2 (MARK2) protein has a substantial role in regulation of vital cellular processes like induction of polarity, regulation of cell junctions, cytoskeleton structure and cell differentiation. The abnormal function of this protein has been associated with a number of pathological conditions like Alzheimer disease, autism, several carcinomas and development of virulent effects ofHelicobacter pyloriββαβββ.
authors.affiliation: Biophysics and Computational Biology Laboratory, Department of Biology, College of Sciences, Shiraz University, Shiraz, Iran.
authors.forename: Sajjad
authors.initials: S
authors.lastname: Ahrari
authors.affiliation: Biophysics and Computational Biology Laboratory, Department of Biology, College of Sciences, Shiraz University, Shiraz, Iran; Institute of Biotechnology, Shiraz University, Shiraz, Iran.
authors.forename: Navid
authors.initials: N
authors.lastname: Mogharrab
keywords: Auto-inhibition; Kinase protein regulation; MARK2; Molecular dynamics simulation; Molecular modeling; UBA domain