title: Bleeding Diatheses: Approach to the Patient Who Bleeds or Has Abnormal Coagulation.
abstract: Many complex elements contribute to normal hemostasis, and an imbalance of these elements may lead to abnormal bleeding. In addition to evaluating medication effects, the hematologist must evaluate for congenital or acquired deficiencies in coagulation factors and platelet disorders. This evaluation should include a thorough bleeding history with careful attention to prior hemostatic challenges and common laboratory testing, including coagulation studies and/or functional platelet assays. An accurate diagnosis of a bleeding diathesis and selection of appropriate treatment are greatly aided by a basic understanding of the mechanisms of disease and the tests used to diagnose them.
authors.affiliation: Department of Medicine, Division of Hematology and Medical Oncology, Weill Cornell Medicine and New York Presbyterian Hospital, 520 East 70th Street, Starr Pavilion, 3rd Floor, New York, NY 10065, USA. Electronic address: mnp9005@nyp.org.
authors.forename: Marcia
authors.initials: M
authors.lastname: Paddock
authors.affiliation: Department of Medicine, Division of Hematology and Medical Oncology, Weill Cornell Medicine and New York Presbyterian Hospital, 520 East 70th Street, Starr Pavilion, 3rd Floor, New York, NY 10065, USA.
authors.forename: John
authors.initials: J
authors.lastname: Chapin
mesh_terms: D001778:Blood Coagulation Disorders / Q000175:diagnosis* / Q000503:physiopathology / Q000628:therapy*; D003937:Diagnosis, Differential; D019468:Disease Management; D004198:Disease Susceptibility; D006403:Hematologic Tests; D006487:Hemostasis; D006801:Humans; D011320:Primary Health Care
keywords: Bleeding disorders; Coagulation; Hemophilia; Platelet defects; von Willebrand disease