title: The Reciprocal Principle of Selectand-Selector-Systems in Supramolecular Chromatography †.
abstract: In selective chromatography and electromigration methods, supramolecular recognition of selectands and selectors is due to the fast and reversible formation of association complexes governed by thermodynamics. Whereas the selectand molecules to be separated are always present in the mobile phase, the selector employed for the separation of the selectands is either part of the stationary phase or is added to the mobile phase. By thereciprocalprinciple, the roles of selector and selectand can be reversed. In this contribution in honor of Professor Stig Allenmark, the evolution of thereciprocalprinciple in chromatography is reviewed and its advantages and limitations are outlined. Variousreciprocalscenarios, including library approaches, are discussed in efforts to optimize selectivity in separation science.
authors.affiliation: Institute of Organic Chemistry, University of Tübingen, Auf der Morgenstelle 18, 72076 Tübingen, Germany. volker.schurig@uni-tuebingen.de.
authors.forename: Volker
authors.initials: V
authors.lastname: Schurig
mesh_terms: D002845:Chromatography / Q000379:methods*; D003505:Cyclodextrins / Q000737:chemistry; D055808:Drug Discovery / Q000379:methods; D037741:Fullerenes / Q000737:chemistry; D046911:Macromolecular Substances / Q000737:chemistry* / Q000302:isolation & purification*; D037742:Nanotubes, Carbon / Q000737:chemistry; D009930:Organic Chemicals / Q000737:chemistry / Q000302:isolation & purification; D013237:Stereoisomerism
chemical_list: D003505:Cyclodextrins; D037741:Fullerenes; D046911:Macromolecular Substances; D037742:Nanotubes, Carbon; D009930:Organic Chemicals
keywords: calixarenes; chiral recognition; chiral stationary phases; combinatorial libraries; congeners; cyclodextrins; cyclopeptides; electromigration methods; enantiomers; fullerenes; molecular recognition; reciprocal principle; selectand; selector; single-walled nanotubes (SWCNTs); supramolecular chromatography