title: Occurrence of Diverse Antimicrobial Resistance Determinants in Genetically Unrelated Biocide Tolerant Klebsiella pneumoniae.
abstract: Nosocomial infections due to Klebsiella pneumoniae is a significant problem in health care settings worldwide. In this study, we examined the antimicrobial susceptibility, genetic profiles and mechanisms of antibiotic resistance in K. pneumoniae isolates of Indian origin. To our knowledge this is the first report demonstrating the high prevalence of β-lactamases, aminoglycoside modifying enzymes, quinolone resistance genes besides demonstrating the involvement of active efflux in K. pneumoniae Indian isolates. This study has enabled us to correlate the phenotypic and genotypic characteristics in K. pneumoniae, providing an important base for continued monitoring and epidemiological studies of this emerging nosocomial pathogen in Indian hospitals.
authors.affiliation: Council of Scientific Industrial Research- Institute of Microbial Technology, Sector 39 A, Chandigarh, 160036, India.
authors.forename: Amitabha
authors.initials: A
authors.lastname: Mondal
authors.affiliation: Council of Scientific Industrial Research- Institute of Microbial Technology, Sector 39 A, Chandigarh, 160036, India.
authors.forename: Manjunath
authors.initials: M
authors.lastname: Venkataramaiah
authors.affiliation: Council of Scientific Industrial Research- Institute of Microbial Technology, Sector 39 A, Chandigarh, 160036, India.
authors.forename: Govindan
authors.initials: G
authors.lastname: Rajamohan
authors.affiliation: Council of Scientific Industrial Research- Institute of Microbial Technology, Sector 39 A, Chandigarh, 160036, India.
authors.forename: Vijaya Bharathi
authors.initials: VB
authors.lastname: Srinivasan
mesh_terms: D000617:Aminoglycosides / Q000378:metabolism; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003428:Cross Infection; D024881:Drug Resistance, Bacterial; D005838:Genotype; D006801:Humans; D007710:Klebsiella Infections / Q000382:microbiology; D007711:Klebsiella pneumoniae / Q000145:classification / Q000187:drug effects / Q000235:genetics*; D008826:Microbial Sensitivity Tests; D010802:Phylogeny; D015363:Quinolones / Q000494:pharmacology*; D001618:beta-Lactamases / Q000235:genetics
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D015363:Quinolones; D001618:beta-Lactamases