title: 1H-MRS metabolite's ratios show temporal alternation in temporal lobe seizure: Comparison between interictal and postictal phases.
abstract: To determine1H-MRSI metabolites changes in interictal and postictal phases of patients suffering from mesial temporal lobe epilepsy with hippocampal sclerosis and lateralization of seizure foci.
  
  
  
  MR spectroscopic imaging was performed in 5 adult patients with refractory temporal lobe epilepsy interictally and immediately after the seizure and in 4 adult control subjects. All patients underwent MR imaging and VideoEEG Monitoring.
  
  
  
  The results showed statistically significant decreases in N-acetylaspartate/Creatine, N-acetylaspartate/Choline and N-acetylaspartate/(creatine+choline) immediately after ictus in ipsilateral hippocampus as compared with control data and contralateral hippocampus of patients while no statistically significant difference was presented in interictal phase.
  
  
  
  The present study clearly indicates1H-MRS abnormalities following an ictus of temporal lobe epilepsy with metabolite recovery in interictal phase. This finding suggests postictal1H-MRS as a possible useful tool to assist in lateralizing and localizing of seizure foci in epileptic patients with structural lesions.
authors.affiliation: Comprehensive Epilepsy Program, Epilepsy Monitoring Unit, Pars Hospital, Tehran, Iran.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Fadaie
authors.affiliation: Quantitative MR Imaging and Spectroscopy Group, Research Center for Molecular and Cellular Imaging, Tehran, Iran; Department of Biomedical Engineering and Medical Physics, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Neda Mohammadi
authors.initials: NM
authors.lastname: Mobarakeh
authors.affiliation: Comprehensive Epilepsy Program, Epilepsy Monitoring Unit, Pars Hospital, Tehran, Iran.
authors.forename: Sayed Sohrab Hashemi
authors.initials: SS
authors.lastname: Fesharaki
authors.affiliation: Department of Neurology, School of Medicine, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Mohammad Hossein
authors.initials: MH
authors.lastname: Harirchian
authors.affiliation: Department of Radiology, Iran University of Medical Sciences, Tehran, Iran.
authors.forename: Homayoun Hadizadeh
authors.initials: HH
authors.lastname: Kharazi
authors.affiliation: Quantitative MR Imaging and Spectroscopy Group, Research Center for Molecular and Cellular Imaging, Tehran, Iran; Department of Biomedical Engineering and Medical Physics, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Hamidreza Saligheh
authors.initials: HS
authors.lastname: Rad
authors.affiliation: Isfahan Neurosciences Research Center, Neurology Department, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address: Mehvari@hotmail.com.
authors.forename: Jafar Mehvari
authors.initials: JM
authors.lastname: Habibabadi
mesh_terms: D000328:Adult; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D002794:Choline / Q000378:metabolism; D003404:Creatinine / Q000378:metabolism; D000069279:Drug Resistant Epilepsy / Q000000981:diagnostic imaging / Q000378:metabolism*; D004569:Electroencephalography; D004833:Epilepsy, Temporal Lobe / Q000000981:diagnostic imaging / Q000378:metabolism*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D066244:Proton Magnetic Resonance Spectroscopy; D012640:Seizures / Q000000981:diagnostic imaging / Q000378:metabolism*; D013702:Temporal Lobe / Q000000981:diagnostic imaging / Q000378:metabolism*; D013997:Time Factors; D014741:Video Recording; D055815:Young Adult
chemical_list: D001224:Aspartic Acid; C000179:N-acetylaspartate; D003404:Creatinine; D002794:Choline
keywords: Metabolites ratio; Proton MR spectroscopy imaging; Seizure; Temporal lobe epilepsy