title: Discrepancy between electroencephalography and hemodynamics in a patient with Cockayne syndrome during general anesthesia.
abstract: Cockayne syndrome is a kind of progeria with autosomal chromosome recessiveness described first by Cockayne in 1936. Patients with this syndrome were characterized by retarded growth, cerebral atrophy, and mental retardation. We experienced an anesthetic management of a patient with Cockayne syndrome, who underwent dental treatment twice. The primary concern was discrepancy between electroencephalography and hemodynamics. The values of bispectral index showed a sharp fall to 1 digit and suppression ratio more than 40, while hemodynamics was stable during induction of anesthesia with sevoflurane 8%. We should pay attention to anesthetic depth in the central nervous system in patients with Cockayne syndrome. Titration of anesthetics should be performed by the information from electroencephalography.
authors.affiliation: Department of Dental Anesthesiology, Kyushu University Hospital, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. Electronic address: tsukamoto@dent.kyushu-u.ac.jp.
authors.forename: Masanori
authors.initials: M
authors.lastname: Tsukamoto
authors.affiliation: Department of Dental Anesthesiology, Faculty of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. Electronic address: hitosugi@dent.kyushu-u.ac.jp.
authors.forename: Takashi
authors.initials: T
authors.lastname: Hitosugi
authors.affiliation: Department of Dental Anesthesiology, Faculty of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. Electronic address: yokoyama@dent.kyushu-u.ac.jp.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Yokoyama
mesh_terms: D000293:Adolescent; D000768:Anesthesia, General; D003057:Cockayne Syndrome / Q000601:surgery*; D004569:Electroencephalography / Q000187:drug effects*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans
keywords: Cokayne syndrome; Electroencephalograhpy; General anesthesia