title: The Value of Thromboelastography for Bleeding Risk Prediction in Hematologic Diseases.
abstract: BACKGROUND
  This study aimed to explore the correlations between thromboelastography (TEG) parameters with platelet (PLT) count and fibrinogen and to evaluate the value of the maximal amplitude (MA) for bleeding risk prediction.
  
  
  METHODS
  A total of 1,559 patients with hematologic diseases underwent PLT counting and TEG tests, and 1,201 of these patients underwent conventional coagulation tests. Patients were divided into a bleeding group and a nonbleeding group according to their clinical records.
  
  
  RESULTS
  Patients in the bleeding group had lower PLT counts, α-angle values, MA values and higher K values (all P < 0.05) than patients in the nonbleeding group. Low PLT counts (≤30 × 109/L) were found in 265 patients and bleeding episodes occurred in 109 patients (41.13%). A total of 99 patients had both low MA values and bleeding episodes in this subgroup. A total of 124 of the 265 patients (46.79%) had hematological malignancies. In the 2 different types of diseases, there was a similar tendency in bleeding risk prediction according to the receiver operating characteristic curves. The curves using both the PLT counts and MA values show a higher sensitivity and a slightly lower specificity than those of the PLT count or MA alone.
  
  
  CONCLUSIONS
  There are some correlations between the TEG parameters and the traditional hemostatic parameters. The combination of the PLT counts and MA values had greater predictive value for bleeding risk in hematological diseases when the PLT counts were at a low level (≤30 × 109/L).
authors.affiliation: Department of Hematology, and Clinical Labratory (NT), Tongji Hospital, Affiliated Huazhong University of Science and Technology, Wuhan, Hubei, China.
authors.forename: Yuzhu
authors.initials: Y
authors.lastname: He
authors.affiliation: Department of Hematology, and Clinical Labratory (NT), Tongji Hospital, Affiliated Huazhong University of Science and Technology, Wuhan, Hubei, China.
authors.forename: Xing
authors.initials: X
authors.lastname: Xin
authors.affiliation: Department of Hematology, and Clinical Labratory (NT), Tongji Hospital, Affiliated Huazhong University of Science and Technology, Wuhan, Hubei, China.
authors.forename: Yudi
authors.initials: Y
authors.lastname: Geng
authors.affiliation: Department of Hematology, and Clinical Labratory (NT), Tongji Hospital, Affiliated Huazhong University of Science and Technology, Wuhan, Hubei, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Tang
authors.affiliation: Department of Hematology, and Clinical Labratory (NT), Tongji Hospital, Affiliated Huazhong University of Science and Technology, Wuhan, Hubei, China.
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Zhou
authors.affiliation: Department of Hematology, and Clinical Labratory (NT), Tongji Hospital, Affiliated Huazhong University of Science and Technology, Wuhan, Hubei, China. Electronic address: lidengju@163.com.
authors.forename: Dengju
authors.initials: D
authors.lastname: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002681:China / Q000453:epidemiology; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D006402:Hematologic Diseases / Q000150:complications* / Q000175:diagnosis; D006470:Hemorrhage / Q000453:epidemiology / Q000209:etiology*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D012372:ROC Curve; D018570:Risk Assessment; D013916:Thrombelastography; D055815:Young Adult
chemical_list: D005340:Fibrinogen
keywords: Bleeding; Fibrinogen; Platelet; TEG; Thromboelastography