title: Simplexolides A-E and plakorfuran A, six butyrate derived polyketides from the marine spongePlakortis simplex.
abstract: Six new polyketides, simplexolides A-E (1-5) and a furan ester, plakorfuran A (6), together with four known furanylidenic methyl esters (7-10) were isolated from the marine spongePlakortis simplex. Compounds1-5feature a tetrahydrofuran ring openedseco-plakortoneskeleton. These new structures, including relative configurations, were determined on the basis of extensive analysis of spectroscopic data. The absolute configurations of1-6were established by the modified Mosher's method, and the CD exciton chirality method. However, configurations of the remote stereocenters at C-8 in compounds1-5were not determined. Antifungal, cytotoxicity, antileismanial, and antimalarial activities of these poly-ketides were evaluated.
authors.affiliation: Laboratory of Marine Drugs, Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai 200003, People's Republic of China; Department of Pharmacy, Shanghai Children's Hospital, Shanghai Jiao Tong University, 1400 West Beijing Road, Shanghai 200040, People's Republic of China.
authors.forename: Xiang-Fang
authors.initials: XF
authors.lastname: Liu
authors.affiliation: Department of Pharmacy, Shanghai Children's Hospital, Shanghai Jiao Tong University, 1400 West Beijing Road, Shanghai 200040, People's Republic of China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Shen
authors.affiliation: Laboratory of Marine Drugs, Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai 200003, People's Republic of China; Department of Pharmacognosy and the National Center for Natural Products Research (NCNPR), School of Pharmacy, The University of Mississippi, University, MS 38677, USA.
authors.forename: Fan
authors.initials: F
authors.lastname: Yang
authors.affiliation: Department of Pharmacognosy and the National Center for Natural Products Research (NCNPR), School of Pharmacy, The University of Mississippi, University, MS 38677, USA.
authors.forename: Mark T
authors.initials: MT
authors.lastname: Hamann
authors.affiliation: Laboratory of Marine Drugs, Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai 200003, People's Republic of China.
authors.forename: Wei-Hua
authors.initials: WH
authors.lastname: Jiao
authors.affiliation: Laboratory of Marine Drugs, Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai 200003, People's Republic of China.
authors.forename: Hong-Jun
authors.initials: HJ
authors.lastname: Zhang
authors.affiliation: Laboratory of Marine Drugs, Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai 200003, People's Republic of China.
authors.forename: Wan-Sheng
authors.initials: WS
authors.lastname: Chen
authors.affiliation: Laboratory of Marine Drugs, Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai 200003, People's Republic of China.
authors.forename: Hou-Wen
authors.initials: HW
authors.lastname: Lin
keywords: Absolute configuration; Antifungal; Antimalarial; Cytotoxicity; Mosher's method; Plakortis simplex; Simplexolide