title: Targeting of Tumor-Associated Glycoforms of MUC1 with CAR T Cells.
abstract: We read with interest the manuscript by June and colleagues published recently in Immunity in which they describe targeting of aberrantly glycosylated tumor-associated cell membrane mucin MUC1 using chimeric antigen receptor-engineered human T cells (Posey et al., 2016). In that study, the authors used a second generation 4-1BB costimulatory-molecule-based chimeric antigen receptor (CAR) (Imai et al., 2004) in which targeting was achieved using a single-chain variable fragment (scFv) derived from the 5E5 antibody. This CAR selectively binds MUC1 that carries the Tn or sialyl (S)Tn glycan. Both of these truncated glycans are aberrantly expressed on the MUC1 glycoprotein in a spectrum of malignancies and consequently represent attractive targets for immunotherapeutic exploitation.
authors.affiliation: King's College London, Division of Cancer Studies, Guy's Hospital, Great Maze Pond, London SE1 9RT, UK; Department of Clinical Immunology and Allergy, King's College Hospital NHS Foundation Trust, Denmark Hill, London SE5 9RS, UK; Department of Immunology, Eastbourne Hospital, Kings Drive, Eastbourne, East Sussex, BN21 2UD, UK. Electronic address: john.maher@kcl.ac.uk.
authors.forename: John
authors.initials: J
authors.lastname: Maher
authors.affiliation: King's College London, Division of Cancer Studies, Guy's Hospital, Great Maze Pond, London SE1 9RT, UK.
authors.forename: Scott
authors.initials: S
authors.lastname: Wilkie
authors.affiliation: King's College London, Division of Cancer Studies, Guy's Hospital, Great Maze Pond, London SE1 9RT, UK.
authors.forename: David M
authors.initials: DM
authors.lastname: Davies
authors.affiliation: Department of Immunobiology, King's College London, London SE1 9RT, UK.
authors.forename: Sefina
authors.initials: S
authors.lastname: Arif
authors.affiliation: King's College London, Division of Cancer Studies, Guy's Hospital, Great Maze Pond, London SE1 9RT, UK.
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Picco
authors.affiliation: Université Lille, 59650 Villeneuve-d'Ascq, France.
authors.forename: Sylvain
authors.initials: S
authors.lastname: Julien
authors.affiliation: Barts Cancer Institute, Queen Mary University of London, London EC1M 6BQ, UK.
authors.forename: Julie
authors.initials: J
authors.lastname: Foster
authors.affiliation: King's College London, Division of Cancer Studies, Guy's Hospital, Great Maze Pond, London SE1 9RT, UK.
authors.forename: Joy
authors.initials: J
authors.lastname: Burchell
authors.affiliation: King's College London, Division of Cancer Studies, Guy's Hospital, Great Maze Pond, London SE1 9RT, UK.
authors.forename: Joyce
authors.initials: J
authors.lastname: Taylor-Papadimitriou
mesh_terms: D000951:Antigens, Neoplasm; D006031:Glycosylation; D006801:Humans; D018396:Mucin-1 / Q000276:immunology*; D009369:Neoplasms / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D000951:Antigens, Neoplasm; D018396:Mucin-1