title: Enhancement of interaction of L-929 cells with functionalized graphene via COOH+ion implantation vs. chemical method.
abstract: Low hydrophilicity of graphene is one of the major obstacles for biomaterials application. To create some hydrophilic groups on graphene is addressed this issue. Herein, COOH+ion implantation modified graphene (COOH+/graphene) and COOH functionalized graphene were designed by physical ion implantation and chemical methods, respectively. The structure and surface properties of COOH+/graphene and COOH functionalized graphene were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), Raman spectroscopy, X-ray photoelectron spectroscopy (XPS), and contact angle measurement. Compared with graphene, COOH+/graphene and COOH functionalized graphene revealed improvement of cytocompatibility, including in vitro cell viability and morphology. More importantly, COOH+/graphene exhibited better improvement effects than functionalized graphene. For instance, COOH+/graphene with 1 × 1018ions/cm2showed the best cell-viability, proliferation and stretching. This study demonstrated that ion implantation can better improve the cytocompatibility of the graphene.
authors.affiliation: Energy &Materials Engineering Centre, College of Physics and Materials Science, Tianjin Normal University, Tianjin 300387, China.|Tianjin International Joint Research Centre of Surface Technology for Energy Storage Materials, Tianjin 300387, China.
authors.forename: Meng-Li
authors.initials: ML
authors.lastname: Zhao
authors.affiliation: Energy &Materials Engineering Centre, College of Physics and Materials Science, Tianjin Normal University, Tianjin 300387, China.|Tianjin International Joint Research Centre of Surface Technology for Energy Storage Materials, Tianjin 300387, China.
authors.forename: Xiao-Qi
authors.initials: XQ
authors.lastname: Liu
authors.affiliation: Energy &Materials Engineering Centre, College of Physics and Materials Science, Tianjin Normal University, Tianjin 300387, China.|Tianjin International Joint Research Centre of Surface Technology for Energy Storage Materials, Tianjin 300387, China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Cao
authors.affiliation: Energy &Materials Engineering Centre, College of Physics and Materials Science, Tianjin Normal University, Tianjin 300387, China.|Tianjin International Joint Research Centre of Surface Technology for Energy Storage Materials, Tianjin 300387, China.
authors.forename: Xi-Fei
authors.initials: XF
authors.lastname: Li
authors.affiliation: Energy &Materials Engineering Centre, College of Physics and Materials Science, Tianjin Normal University, Tianjin 300387, China.|Tianjin International Joint Research Centre of Surface Technology for Energy Storage Materials, Tianjin 300387, China.
authors.forename: De-Jun
authors.initials: DJ
authors.lastname: Li
authors.affiliation: Department of Mechanical &Materials Engineering, Western University, London, ON, Canada.
authors.forename: Xue-Liang
authors.initials: XL
authors.lastname: Sun
authors.affiliation: Tianjin Institute of Urological Surgery, Tianjin Medical University, Tianjin 300070, China.
authors.forename: Han-Qing
authors.initials: HQ
authors.lastname: Gu
authors.affiliation: Tianjin Institute of Urological Surgery, Tianjin Medical University, Tianjin 300070, China.
authors.forename: Rong-Xin
authors.initials: RX
authors.lastname: Wan
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D002448:Cell Adhesion; D002460:Cell Line; D049109:Cell Proliferation; D002470:Cell Survival; D006108:Graphite / Q000737:chemistry*; D051379:Mice
chemical_list: D001672:Biocompatible Materials; D006108:Graphite