title: Advances on plant-pathogen interactions from molecular toward systems biology perspectives.
abstract: In the past 2 decades, progress in molecular analyses of the plant immune system has revealed key elements of a complex response network. Current paradigms depict the interaction of pathogen-secreted molecules with host target molecules leading to the activation of multiple plant response pathways. Further research will be required to fully understand how these responses are integrated in space and time, and exploit this knowledge in agriculture. In this review, we highlight systems biology as a promising approach to reveal properties of molecular plant-pathogen interactions and predict the outcome of such interactions. We first illustrate a few key concepts in plant immunity with a network and systems biology perspective. Next, we present some basic principles of systems biology and show how they allow integrating multiomics data and predict cell phenotypes. We identify challenges for systems biology of plant-pathogen interactions, including the reconstruction of multiscale mechanistic models and the connection of host and pathogen models. Finally, we outline studies on resistance durability through the robustness of immune system networks, the identification of trade-offs between immunity and growth and in silico plant-pathogen co-evolution as exciting perspectives in the field. We conclude that the development of sophisticated models of plant diseases incorporating plant, pathogen and climate properties represent a major challenge for agriculture in the future.
authors.affiliation: LIPM, Université de Toulouse, INRA, CNRS, Castanet-Tolosan, France.
authors.forename: Rémi
authors.initials: R
authors.lastname: Peyraud
authors.affiliation: LIPM, Université de Toulouse, INRA, CNRS, Castanet-Tolosan, France.
authors.forename: Ullrich
authors.initials: U
authors.lastname: Dubiella
authors.affiliation: LIPM, Université de Toulouse, INRA, CNRS, Castanet-Tolosan, France.
authors.forename: Adelin
authors.initials: A
authors.lastname: Barbacci
authors.affiliation: LIPM, Université de Toulouse, INRA, CNRS, Castanet-Tolosan, France.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Genin
authors.affiliation: LIPM, Université de Toulouse, INRA, CNRS, Castanet-Tolosan, France.
authors.forename: Sylvain
authors.initials: S
authors.lastname: Raffaele
authors.affiliation: LIPM, Université de Toulouse, INRA, CNRS, Castanet-Tolosan, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Roby
mesh_terms: D054884:Host-Pathogen Interactions / Q000276:immunology; D010935:Plant Diseases / Q000276:immunology; D057865:Plant Immunity / Q000502:physiology; D049490:Systems Biology / Q000379:methods*
keywords: genome-scale metabolic network; immunity; modeling; network; plant-pathogen interactions; robustness; systems biology; trade-off