title: Association of BDNF Val66MET Polymorphism With Parkinson's Disease and Depression and Anxiety Symptoms.
abstract: An association between Parkinson's disease (PD) and brain-derived neurotrophic factor (BDNF) was suggested by several studies, with contradictory results. BDNF is necessary for the survival of dopaminergic neurons in substantia nigra. Val66Met is a common polymorphism of the BDNF gene that affects cognitive and motor processes. The authors studied 104 Brazilian patients with PD and 96 control participants. The G/G genotype was significantly associated with depression and anxiety symptoms and development of PD. This is the first study that associates this genotype with PD.
authors.affiliation: From the Physiology Department, Universidade Federal do Rio Grande do Norte, Natal, Brazil (FCC, CLCC); Campus Arapiraca, Universidade Federal de Alagoas, Arapiraca, Brazil (DGC, MRB, TGA); Integrated Medicine Department, Universidade Federal do Rio Grande do Norte, Natal, Brazil (LGOJ, ABSN, COGJ); Bioscience Department, Universidade Federal de São Paulo, Santos, Brazil and Pharmacology Department, Universidade Federal de São Paulo, São Paulo, Brazil (AMR, RHS).
authors.forename: Fernanda Carvalho
authors.initials: FC
authors.lastname: Cagni
authors.affiliation: From the Physiology Department, Universidade Federal do Rio Grande do Norte, Natal, Brazil (FCC, CLCC); Campus Arapiraca, Universidade Federal de Alagoas, Arapiraca, Brazil (DGC, MRB, TGA); Integrated Medicine Department, Universidade Federal do Rio Grande do Norte, Natal, Brazil (LGOJ, ABSN, COGJ); Bioscience Department, Universidade Federal de São Paulo, Santos, Brazil and Pharmacology Department, Universidade Federal de São Paulo, São Paulo, Brazil (AMR, RHS).
authors.forename: Clarissa Loureiro das Chagas
authors.initials: CLDC
authors.lastname: Campêlo
authors.affiliation: From the Physiology Department, Universidade Federal do Rio Grande do Norte, Natal, Brazil (FCC, CLCC); Campus Arapiraca, Universidade Federal de Alagoas, Arapiraca, Brazil (DGC, MRB, TGA); Integrated Medicine Department, Universidade Federal do Rio Grande do Norte, Natal, Brazil (LGOJ, ABSN, COGJ); Bioscience Department, Universidade Federal de São Paulo, Santos, Brazil and Pharmacology Department, Universidade Federal de São Paulo, São Paulo, Brazil (AMR, RHS).
authors.forename: Daniel Gomes
authors.initials: DG
authors.lastname: Coimbra
authors.affiliation: From the Physiology Department, Universidade Federal do Rio Grande do Norte, Natal, Brazil (FCC, CLCC); Campus Arapiraca, Universidade Federal de Alagoas, Arapiraca, Brazil (DGC, MRB, TGA); Integrated Medicine Department, Universidade Federal do Rio Grande do Norte, Natal, Brazil (LGOJ, ABSN, COGJ); Bioscience Department, Universidade Federal de São Paulo, Santos, Brazil and Pharmacology Department, Universidade Federal de São Paulo, São Paulo, Brazil (AMR, RHS).
authors.forename: Mayara Rodrigues
authors.initials: MR
authors.lastname: Barbosa
authors.affiliation: From the Physiology Department, Universidade Federal do Rio Grande do Norte, Natal, Brazil (FCC, CLCC); Campus Arapiraca, Universidade Federal de Alagoas, Arapiraca, Brazil (DGC, MRB, TGA); Integrated Medicine Department, Universidade Federal do Rio Grande do Norte, Natal, Brazil (LGOJ, ABSN, COGJ); Bioscience Department, Universidade Federal de São Paulo, Santos, Brazil and Pharmacology Department, Universidade Federal de São Paulo, São Paulo, Brazil (AMR, RHS).
authors.forename: Luiz Gonzaga Oliveira
authors.initials: LGO
authors.lastname: Júnior
authors.affiliation: From the Physiology Department, Universidade Federal do Rio Grande do Norte, Natal, Brazil (FCC, CLCC); Campus Arapiraca, Universidade Federal de Alagoas, Arapiraca, Brazil (DGC, MRB, TGA); Integrated Medicine Department, Universidade Federal do Rio Grande do Norte, Natal, Brazil (LGOJ, ABSN, COGJ); Bioscience Department, Universidade Federal de São Paulo, Santos, Brazil and Pharmacology Department, Universidade Federal de São Paulo, São Paulo, Brazil (AMR, RHS).
authors.forename: Antônio Braz Silva
authors.initials: ABS
authors.lastname: Neto
authors.affiliation: From the Physiology Department, Universidade Federal do Rio Grande do Norte, Natal, Brazil (FCC, CLCC); Campus Arapiraca, Universidade Federal de Alagoas, Arapiraca, Brazil (DGC, MRB, TGA); Integrated Medicine Department, Universidade Federal do Rio Grande do Norte, Natal, Brazil (LGOJ, ABSN, COGJ); Bioscience Department, Universidade Federal de São Paulo, Santos, Brazil and Pharmacology Department, Universidade Federal de São Paulo, São Paulo, Brazil (AMR, RHS).
authors.forename: Alessandra Mussi
authors.initials: AM
authors.lastname: Ribeiro
authors.affiliation: From the Physiology Department, Universidade Federal do Rio Grande do Norte, Natal, Brazil (FCC, CLCC); Campus Arapiraca, Universidade Federal de Alagoas, Arapiraca, Brazil (DGC, MRB, TGA); Integrated Medicine Department, Universidade Federal do Rio Grande do Norte, Natal, Brazil (LGOJ, ABSN, COGJ); Bioscience Department, Universidade Federal de São Paulo, Santos, Brazil and Pharmacology Department, Universidade Federal de São Paulo, São Paulo, Brazil (AMR, RHS).
authors.forename: Clécio de Oliveira Godeiro
authors.initials: COG
authors.lastname: Júnior
authors.affiliation: From the Physiology Department, Universidade Federal do Rio Grande do Norte, Natal, Brazil (FCC, CLCC); Campus Arapiraca, Universidade Federal de Alagoas, Arapiraca, Brazil (DGC, MRB, TGA); Integrated Medicine Department, Universidade Federal do Rio Grande do Norte, Natal, Brazil (LGOJ, ABSN, COGJ); Bioscience Department, Universidade Federal de São Paulo, Santos, Brazil and Pharmacology Department, Universidade Federal de São Paulo, São Paulo, Brazil (AMR, RHS).
authors.forename: Tiago
authors.initials: T
authors.lastname: Gomes de Andrade
authors.affiliation: From the Physiology Department, Universidade Federal do Rio Grande do Norte, Natal, Brazil (FCC, CLCC); Campus Arapiraca, Universidade Federal de Alagoas, Arapiraca, Brazil (DGC, MRB, TGA); Integrated Medicine Department, Universidade Federal do Rio Grande do Norte, Natal, Brazil (LGOJ, ABSN, COGJ); Bioscience Department, Universidade Federal de São Paulo, Santos, Brazil and Pharmacology Department, Universidade Federal de São Paulo, São Paulo, Brazil (AMR, RHS).
authors.forename: Regina Helena
authors.initials: RH
authors.lastname: Silva
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001007:Anxiety / Q000235:genetics*; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D003863:Depression / Q000235:genetics*; D018450:Disease Progression; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D008715:Methionine / Q000235:genetics; D008875:Middle Aged; D010300:Parkinson Disease / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D014633:Valine / Q000235:genetics
chemical_list: D019208:Brain-Derived Neurotrophic Factor; C579455:BDNF protein, human; D008715:Methionine; D014633:Valine
keywords: Anxiety Disorders (Neuropsychiatric Aspects); Depression; Genetics; Parkinson’s Disease