title: Two new monoterpenes from Sibiraea laevigata.
abstract: Two new monoterpenes, 3-(2-oxo-4-methyl-3-pentenyl)furan-5H-2-one (1) and 3-[(2E)-4-hydroxyl-4-methyl-2-pentenyl)]furan-5H-2-one (2), along with eight known compounds (3-10), were isolated from the stalks and infructescence of Sibiraea laevigata. Their structures were elucidated by spectroscopic methods including extensive 1D and 2D NMR techniques. In addition, all of these isolates were evaluated for their cytotoxic and antioxidant activities. The results showed that compounds 5-7 displayed cytotoxicity with IC50values ranging from 34.8 to 43.2 μg ml-1against tumor cell lines. Furthermore, 5 and 9 showed antioxidant activities.
authors.affiliation: a Animal Disease and Veterinary Pharmaceutical Institute, Chongqing Academy of Animal Sciences , Rongchang 402460 , China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Deng
authors.affiliation: b Key Laboratory of Tibetan Medicine Research of CAS and Key Laboratory for Tibetan Medicine of Qinghai Province , Northwest Institute of Plateau Biology, Chinese Academy of Sciences , Xining 810008 , China.|c University of Chinese Academy of Sciences , Beijing 100049 , China.
authors.forename: Jian-Qiang
authors.initials: JQ
authors.lastname: Zhao
authors.affiliation: b Key Laboratory of Tibetan Medicine Research of CAS and Key Laboratory for Tibetan Medicine of Qinghai Province , Northwest Institute of Plateau Biology, Chinese Academy of Sciences , Xining 810008 , China.
authors.forename: Li-Juan
authors.initials: LJ
authors.lastname: Mei
authors.affiliation: b Key Laboratory of Tibetan Medicine Research of CAS and Key Laboratory for Tibetan Medicine of Qinghai Province , Northwest Institute of Plateau Biology, Chinese Academy of Sciences , Xining 810008 , China.
authors.forename: Yan-Duo
authors.initials: YD
authors.lastname: Tao
mesh_terms: D000975:Antioxidants / Q000737:chemistry; D001713:Biphenyl Compounds / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D039821:Monoterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019906:Nuclear Magnetic Resonance, Biomolecular; D010851:Picrates / Q000494:pharmacology; D027824:Rosaceae / Q000737:chemistry*
chemical_list: C000622372:3-((2E)-4-hydroxyl-4-methyl-2-pentenyl))furan-5H-2-one; C000622371:3-(2-oxo-4-methyl-3-pentenyl)furan-5H-2-one; D000975:Antioxidants; D001713:Biphenyl Compounds; D004365:Drugs, Chinese Herbal; D039821:Monoterpenes; D010851:Picrates; C004931:1,1-diphenyl-2-picrylhydrazyl
keywords: Rosaceae; Sibiraea laevigata; antioxidant activity; cytotoxic activity; monoterpenes