title: Significance of Exhaled Breath Test in Clinical Diagnosis: A Special Focus on the Detection of Diabetes Mellitus.
abstract: Analysis of volatile organic compounds (VOCs) emanating from human exhaled breath can provide deep insight into the status of various biochemical processes in the human body. VOCs can serve as potential biomarkers of physiological and pathophysiological conditions related to several diseases. Breath VOC analysis, a noninvasive and quick biomonitoring approach, also has potential for the early detection and progress monitoring of several diseases. This paper gives an overview of the major VOCs present in human exhaled breath, possible biochemical pathways of breath VOC generation, diagnostic importance of their analysis, and analytical techniques used in the breath test. Breath analysis relating to diabetes mellitus and its characteristic breath biomarkers is focused on. Finally, some challenges and limitations of the breath test are discussed.
authors.affiliation: Department of Biomedical Engineering, JIS College of Engineering, Kalyani, West Bengal 741235 India.
authors.forename: Souvik
authors.initials: S
authors.lastname: Das
authors.affiliation: Department of Applied Physics, University of Calcutta, Kolkata, West Bengal 700009 India.
authors.forename: Saurabh
authors.initials: S
authors.lastname: Pal
authors.affiliation: Department of Applied Physics, University of Calcutta, Kolkata, West Bengal 700009 India.
authors.forename: Madhuchhanda
authors.initials: M
authors.lastname: Mitra
keywords: Breath analysis; Breath biomarkers; Diabetes mellitus; Disease diagnosis; Noninvasive method; Volatile organic compound