title: Does routine colonoscopy help diagnose familial adenomatous polyposis in patients presenting with desmoid tumors but no gastrointestinal symptoms?
abstract: OBJECTIVE
  Desmoid tumor (DT) is a rare myofibroblastic proliferative neoplasm, but can occur in up to 26% of patients with familial adenomatous polyposis (FAP). Therefore, DT may be an extraintestinal manifestation of FAP that precedes the development of advanced malignancies. The aim of this study was to identify the incidence of polyps in DT patients and investigate value of colonoscopy for diagnosis of FAP in DT patients without gastrointestinal symptoms.
  
  
  METHODS
  The records of patients diagnosed with DT were retrospectively reviewed using the clinical data warehouse (CDW) system. Clinical data, including location of tumor, type(s) of treatment, and colonoscopic findings, were collected.
  
  
  RESULTS
  Sixty-five patients were diagnosed with DT during the study period; 10 patients received colonoscopies before diagnosis of DT, and 20 patients received colonoscopies after diagnosis of DT. The mean age at diagnosis of DT was 41.9 ± 16.7 years old (range 17-74). Most tumors were extra-abdominal (n = 24, 80.0%), and fewer were intra-abdominal (n = 4, 13.3%) or in an abdominal wall (n = 2, 6.7%). The colonoscopy results revealed one or two tubular adenomas in 11 patients (36.6%), although none of the patients had colorectal polyposis or colorectal cancer.
  
  
  CONCLUSIONS
  None of the patients in our study population had colorectal polyposis. Routine colonoscopy of DT patients without gastrointestinal symptoms seems to have low diagnostic yield for detection of FAP.
authors.affiliation: Department of Surgery, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, South Korea.
authors.forename: Rumi
authors.initials: R
authors.lastname: Shin
authors.affiliation: Department of Orthopedic Surgery, Seoul National University Bundang Hospital, Seongnam, South Korea.
authors.forename: Hwan-Seong
authors.initials: HS
authors.lastname: Cho
authors.affiliation: Department of Surgery, Seoul National University Bundang Hospital, 82, Gumi-ro 173beon-gil, Bundang-gu, Seongnam, 13620, South Korea. kdw@snubh.org.|Korean Hereditary Tumor Registry, Seoul National University College of Medicine, Seoul, South Korea. kdw@snubh.org.
authors.forename: Duck-Woo
authors.initials: DW
authors.lastname: Kim
authors.affiliation: Medical Research Collaborating Center, Seoul National University Bundang Hospital, Seongnam, South Korea.
authors.forename: So Yeon
authors.initials: SY
authors.lastname: Ahn
authors.affiliation: Department of Surgery, Soonchunhyang University Gumi Hospital, Gumi, South Korea.
authors.forename: Myong Hoon
authors.initials: MH
authors.lastname: Ihn
authors.affiliation: Department of Pathology, Seoul National University Bundang Hospital, Seongnam, South Korea.
authors.forename: Hyo Jin
authors.initials: HJ
authors.lastname: Park
authors.affiliation: Department of Surgery, Seoul National University Bundang Hospital, 82, Gumi-ro 173beon-gil, Bundang-gu, Seongnam, 13620, South Korea.
authors.forename: Heung-Kwon
authors.initials: HK
authors.lastname: Oh
authors.affiliation: Department of Surgery, Seoul National University Bundang Hospital, 82, Gumi-ro 173beon-gil, Bundang-gu, Seongnam, 13620, South Korea.
authors.forename: Sung-Bum
authors.initials: SB
authors.lastname: Kang
mesh_terms: D011125:Adenomatous Polyposis Coli / Q000150:complications* / Q000175:diagnosis*; D000293:Adolescent; D000328:Adult; D000368:Aged; D003113:Colonoscopy; D005260:Female; D018222:Desmoid Tumors / Q000150:complications* / Q000175:diagnosis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D055815:Young Adult
keywords: Adenomatous polyposis coli; Colonoscopy; Desmoid disease