title: Edoxaban Was Effective for the Treatment of Deep Vein Thrombosis and Pulmonary Thromboembolism in a Cancer Patient with Antithrombin III Deficiency.
abstract: A 57-year-old man with antithrombin III deficiency with deep vein thrombosis and pulmonary thromboembolism after surgery for colon cancer was managed with warfarin and inferior vena cava filtration. After starting chemotherapy for liver metastasis, the control of his prothrombin time-international normalized ratio in response to warfarin began to fluctuate. Warfarin was changed to edoxaban (an oral direct Factor Xa inhibitor), and he had no recurrence of venous thromboembolism or bleeding for approximately 1 year. We conclude that edoxaban could be a useful treatment option for complicated patients with deep vein thrombosis.
authors.affiliation: Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Kawano
authors.forename: Koji
authors.initials: K
authors.lastname: Maemura
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000627:therapeutic use; D020152:Antithrombin III Deficiency / Q000150:complications*; D003110:Colonic Neoplasms / Q000473:pathology / Q000601:surgery; D006801:Humans; D019934:International Normalized Ratio; D008113:Liver Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000556:secondary; D008297:Male; D008875:Middle Aged; D011655:Pulmonary Embolism / Q000150:complications / Q000188:drug therapy*; D011725:Pyridines / Q000627:therapeutic use*; D013844:Thiazoles / Q000627:therapeutic use*; D020246:Venous Thrombosis / Q000150:complications / Q000188:drug therapy*; D014859:Warfarin / Q000627:therapeutic use
chemical_list: D000925:Anticoagulants; D000970:Antineoplastic Agents; D011725:Pyridines; D013844:Thiazoles; D014859:Warfarin; C552171:edoxaban