title: Mimicking the ocular environment for the study of inflammatory posterior eye disorders.
abstract: The common inflammatory posterior eye disorders, age-related degeneration and glaucoma often lead to irreversible vision loss. Current treatments do not target early stages or prevent disease progression. Consequently, the identification of biomarkers or early disease models that can accurately mimic the pathological processes involved is essential. Although none of the existing models can recapitulate all pathological aspects of these disorders, these models have revealed new therapeutic targets. Efforts to accurately phenotype eye disorders at various disease stages are warranted to generate a 'super' model that can replicate the microenvironment of the eye and associated pathological hallmarks effectively.
authors.affiliation: Discipline of Laboratory Medicine, School of Health and Biomedical Sciences, RMIT University, Bundoora, VIC 3083, Australia.
authors.forename: Nabeela K
authors.initials: NK
authors.lastname: Dulull
authors.affiliation: Discipline of Pharmacy, School of Health and Biomedical Sciences, RMIT University, Bundoora, VIC 3083, Australia.
authors.forename: Thilini R
authors.initials: TR
authors.lastname: Thrimawithana
authors.affiliation: Discipline of Laboratory Medicine, School of Health and Biomedical Sciences, RMIT University, Bundoora, VIC 3083, Australia. Electronic address: faith.kwa@rmit.edu.au.
authors.forename: Faith A A
authors.initials: FAA
authors.lastname: Kwa
mesh_terms: D000818:Animals; D005123:Eye; D005901:Glaucoma; D006801:Humans; D007249:Inflammation; D008268:Macular Degeneration; D008954:Models, Biological