title: Synthesis and characterization of Fe3O4-MPTMS-PLGA nanocomposites for anticancer drug loading and release studies.
abstract: Magnetic nanocomposites (Fe3O4-MPTMS-PLGA) were synthesized by single oil emulsion method and characterized by transmission electron microscopy (TEM), X-Ray diffraction (XRD), and vibrating sample magnetometer (VSM). Particle size of nanocomposites was between 117 nm and 246 nm. High performance liquid chromatography (HPLC) was used to investigate drug loading (paclitaxel, PTX) and release from Fe3O4-MPTMS-PLGA-PTX nanocomposites. The percentages of drug loading and encapsulation efficiency onto nanocomposites were found as 7.35 and 68.58, respectively. Cytotoxities of free anticancer drug and anticancer drug-loaded nanocomposites were determined by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. In vitro cell culture studies indicated that Fe3O4-MPTMS-PLGA-PTX had significant toxicity on MG-63 cancer cells.
authors.affiliation: a Department of Chemical Engineering , Ankara University , Ankara , Turkey.
authors.forename: Ceren
authors.initials: C
authors.lastname: Atila Dinçer
authors.affiliation: a Department of Chemical Engineering , Ankara University , Ankara , Turkey.
authors.forename: Nuray
authors.initials: N
authors.lastname: Yildiz
authors.affiliation: a Department of Chemical Engineering , Ankara University , Ankara , Turkey.
authors.forename: Ayşe
authors.initials: A
authors.lastname: Karakeçili
authors.affiliation: b Department of Chemical Engineering , Hacettepe University , Ankara , Turkey.
authors.forename: Nihal
authors.initials: N
authors.lastname: Aydoğan
authors.affiliation: a Department of Chemical Engineering , Ankara University , Ankara , Turkey.
authors.forename: Ayla
authors.initials: A
authors.lastname: Çalimli
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D045744:Cell Line, Tumor; D060326:Chemistry Techniques, Synthetic; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry*; D065546:Drug Liberation; D006801:Humans; D019344:Lactic Acid / Q000737:chemistry*; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D008689:Methacrylates / Q000737:chemistry*; D053761:Nanocomposites / Q000737:chemistry*; D017646:Organosilicon Compounds / Q000737:chemistry*; D017239:Paclitaxel / Q000737:chemistry / Q000494:pharmacology; D010316:Particle Size; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D058185:Magnetite Nanoparticles; D008689:Methacrylates; D017646:Organosilicon Compounds; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; C505504:3-(trimethoxysilyl)propyl methacrylate; D017239:Paclitaxel
keywords: Fe3O4 nanoparticles; anticancer drug; magnetic polymer nanocomposites; silane compounds