title: Ibuprofen delivery into and through the skin from novel oxidized cellulose-based gels and conventional topical formulations.
abstract: The delivery of ibuprofen into and through the skin from novel formulations containing TEMPO-oxidized cellulose nanofibril-based (TOCN) gels was compared to that from two conventional and commercially available products. The gels were evaluated in-vitro (using both silicone membranes, and pig skin) and in-vivo in human volunteers. All gels showed consistent behaviour in a standard in vitro release test. The stratum corneum (SC) uptake and skin penetration of ibuprofen in vitro from the novel gels and the marketed formulations were generally comparable even though the drug loading in the TOCN-based vehicles was only 20% of that in the 'reference' products. In vivo, the new gels appeared to enhance drug uptake into the SC following a relatively short application time, again matching the performance of the commercial formulations. Taken together, the results of this research provide proof-of-concept for the idea that the sustainable, oxidized cellulose gels may provide more efficient drug delivery into and through the skin, thereby improving drug utilisation and reducing potential adverse effects when such formulations are applied chronically over large skin areas.
authors.affiliation: Centre for Sustainable Chemical Technologies, and Department of Chemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK. Electronic address: duygu.celebi@unilever.com.
authors.forename: Duygu
authors.initials: D
authors.lastname: Celebi
authors.affiliation: Department of Pharmacy & Pharmacology, University of Bath, Claverton Down, Bath BA2 7AY, UK.
authors.forename: Richard H
authors.initials: RH
authors.lastname: Guy
authors.affiliation: Centre for Sustainable Chemical Technologies, and Department of Chemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK.
authors.forename: Karen J
authors.initials: KJ
authors.lastname: Edler
authors.affiliation: Centre for Sustainable Chemical Technologies, and Department of Chemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK.
authors.forename: Janet L
authors.initials: JL
authors.lastname: Scott
mesh_terms: D000279:Administration, Cutaneous; D000328:Adult; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000737:chemistry; D002483:Cellulose, Oxidized / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical / Q000379:methods; D016503:Drug Delivery Systems / Q000379:methods; D005079:Excipients / Q000737:chemistry; D005260:Female; D005782:Gels / Q000008:administration & dosage* / Q000737:chemistry*; D006801:Humans; D007052:Ibuprofen / Q000008:administration & dosage* / Q000378:metabolism*; D008297:Male; D057139:Nanofibers / Q000008:administration & dosage / Q000737:chemistry; D012867:Skin / Q000378:metabolism*; D012869:Skin Absorption; D013552:Swine; D055815:Young Adult
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D002483:Cellulose, Oxidized; D005079:Excipients; D005782:Gels; D007052:Ibuprofen
keywords: Ibuprofen; Oxidized cellulose gel; Skin absorption; Topical formulation; Transdermal delivery