title: Snakes and Hypertension.
abstract: Inhibition of Angiotensin Conversion in Experimental Renovascular Hypertension. By Miller ED Jr, Samuels A, Haber E, and Barger AC. Science 1972; 177:1108-9. Reprinted with permission from AAAS.Constriction of the renal artery and controlled reduction of renal perfusion pressure is followed by a prompt increase in systemic renin activity and a concomitant rise in blood pressure in trained, unanesthetized dogs. The elevated blood pressure induced by the renal artery stenosis can be prevented by prior treatment with the nonapeptide Pyr-Trp-Pro-Arg-Pro-Gln-Ile-Pro-Pro, which blocks conversion of angiotensin I to angiotensin II. Further, the nonapeptide can restore systemic pressure to normal in the early phase of renovascular hypertension. These results offer strong evidence that the renin- angiotensin system is responsible for the initiation of hypertension in the unilaterally nephrectomized dog with renal artery constriction.
authors.affiliation: From the Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medicine Emeritus, Baltimore, Maryland.
authors.forename: Edward D
authors.initials: ED
authors.lastname: Miller
mesh_terms: D000809:Angiotensins / Q000378:metabolism*; D000818:Animals; D004195:Disease Models, Animal; D004285:Dogs; D049673:History, 20th Century; D006973:Hypertension / Q000266:history* / Q000503:physiopathology*; D012078:Renal Artery Obstruction / Q000503:physiopathology*
chemical_list: D000809:Angiotensins