title: Rhesus monkey neural stem cell transplantation promotes neural regeneration in rats with hippocampal lesions.
abstract: Rhesus monkey neural stem cells are capable of differentiating into neurons and glial cells. Therefore, neural stem cell transplantation can be used to promote functional recovery of the nervous system. Rhesus monkey neural stem cells (1 × 105cells/μL) were injected into bilateral hippocampi of rats with hippocampal lesions. Confocal laser scanning microscopy demonstrated that green fluorescent protein-labeled transplanted cells survived and grew well. Transplanted cells were detected at the lesion site, but also in the nerve fiber-rich region of the cerebral cortex and corpus callosum. Some transplanted cells differentiated into neurons and glial cells clustering along the ventricular wall, and integrated into the recipient brain. Behavioral tests revealed that spatial learning and memory ability improved, indicating that rhesus monkey neural stem cells noticeably improve spatial learning and memory abilities in rats with hippocampal lesions.
authors.affiliation: Department of Pathology, Third Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China; Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan Province, China; Second Department of Neurosurgery, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China.
authors.forename: Li-Juan
authors.initials: LJ
authors.lastname: Ye
authors.affiliation: Department of Physiology, Kunming Medical University, Kunming, Yunnan Province, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Bian
authors.affiliation: Department of Pathology, Third Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China.
authors.forename: Yao-Dong
authors.initials: YD
authors.lastname: Fan
authors.affiliation: Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan Province, China.
authors.forename: Zheng-Bo
authors.initials: ZB
authors.lastname: Wang
authors.affiliation: Second Department of Neurosurgery, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China.
authors.forename: Hua-Lin
authors.identifier: 0000-0002-1105-3867
authors.initials: HL
authors.lastname: Yu
authors.affiliation: Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan Province, China.
authors.forename: Yuan-Ye
authors.identifier: 0000-0001-5291-9367
authors.initials: YY
authors.lastname: Ma
authors.affiliation: Department of Radiology, Hainan General Hospital, Haikou, Hainan Province, China.
authors.forename: Feng
authors.identifier: 0000-0002-9129-7895
authors.initials: F
authors.lastname: Chen
keywords: cell transplantation; hippocampal lesion; nerve regeneration; neural regeneration; neural stem cells; rhesus monkey; spatial learning and memory abilities