title: A graphene quantum dot@Fe3O4@SiO2based nanoprobe for drug delivery sensing and dual-modal fluorescence and MRI imaging in cancer cells.
abstract: A novel graphene quantum dot (GQD)@Fe3O4@SiO2based nanoprobe was reported for targeted drug delivery, sensing, dual-modal imaging and therapy. Carboxyl-terminated GQD (C-GQD) was firstly conjugated with Fe3O4@SiO2and then functionalized with cancer targeting molecule folic acid (FA). DOX drug molecules were then loaded on GQD surface of Fe3O4@SiO2@GQD-FA nanoprobe via pi-pi stacking, which resulted in Fe3O4@SiO2@GQD-FA/DOX conjugates based on a FRET mechanism with GQD as donor molecules and DOX as acceptor molecules. Meanwhile, we successfully performed in vitro MRI and fluorescence imaging of living Hela cells and monitored intracellular drug release process using this Fe3O4@SiO2@GQD-FA/DOX nanoprobe. Cell viability study demonstrated the low cytotoxicity of Fe3O4@SiO2@GQD-FA nanocarrier and the enhanced therapeutic efficacy of Fe3O4@SiO2@GQD-FA/DOX nanoprobe for cancer cells. This luminomagnetic nanoprobe will be a potential platform for cancer accurate diagnosis and therapy.
authors.affiliation: Interdisciplinary Division of Biomedical Engineering, the Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, PR China.
authors.forename: Xiaoqian
authors.initials: X
authors.lastname: Su
authors.affiliation: Interdisciplinary Division of Biomedical Engineering, the Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, PR China.
authors.forename: Chunyu
authors.initials: C
authors.lastname: Chan
authors.affiliation: Interdisciplinary Division of Biomedical Engineering, the Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, PR China.
authors.forename: Jingyu
authors.initials: J
authors.lastname: Shi
authors.affiliation: Department of Applied Physics, the Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, PR China.
authors.forename: Ming-Kiu
authors.initials: MK
authors.lastname: Tsang
authors.affiliation: Key Laboratory of Sensing Technology and Biomedical Instruments, Sun Yat-Sen University, Guangzhou, PR China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Pan
authors.affiliation: Interdisciplinary Division of Biomedical Engineering, the Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, PR China.
authors.forename: Changming
authors.initials: C
authors.lastname: Cheng
authors.affiliation: Interdisciplinary Division of Biomedical Engineering, the Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, PR China.
authors.forename: Oudeng
authors.initials: O
authors.lastname: Gerile
authors.affiliation: Interdisciplinary Division of Biomedical Engineering, the Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, PR China. Electronic address: Mo.Yang@polyu.edu.hk.
authors.forename: Mo
authors.initials: M
authors.lastname: Yang
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000493:pharmacokinetics* / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D004317:Doxorubicin / Q000493:pharmacokinetics* / Q000494:pharmacology; D065546:Drug Liberation; D016903:Drug Monitoring / Q000379:methods; D052203:Ferrosoferric Oxide / Q000737:chemistry*; D005453:Fluorescence; D031541:Fluorescence Resonance Energy Transfer / Q000379:methods; D006108:Graphite / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D053758:Nanoparticles / Q000737:chemistry / Q000648:ultrastructure; D009369:Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy*; D061848:Optical Imaging / Q000379:methods; D045663:Quantum Dots / Q000737:chemistry* / Q000648:ultrastructure; D012822:Silicon Dioxide / Q000737:chemistry*
chemical_list: D000903:Antibiotics, Antineoplastic; D012822:Silicon Dioxide; D006108:Graphite; D004317:Doxorubicin; D052203:Ferrosoferric Oxide
keywords: Cell imaging; Drug delivery sensing; Fluorescence resonance energy transfer (FRET); Graphene quantum dots (GQDs); Magnetic resonance imaging (MRI)