title: Antiplasmodial activity of the ethanolic root bark extract of Icacina senegalensis in mice infected by Plasmodium berghei.
abstract: BACKGROUND
  The root of Icacina senegalensis is used for the treatment of malaria and related conditions in southeastern Nigeria.
  
  
  METHODS
  To establish its efficacy, the ethanolic root bark extract was investigated as antiplasmodial agent against Plasmodium berghei in mice. A 4-day suppressive test and the curative effect against established infection models of antiplasmodial studies were used.
  
  
  RESULTS
  The root bark extract of I. senegalensis (50, 100, and 200 mg/kg) exhibited a significant (p<0.05) dose-dependent activity against the parasite based on suppressive and curative study. The antimalarial effect of I. senegalensis is compared with that of chloroquine (10 mg/kg), the standard drug. The ethanolic root bark extract also prolonged the survival time of infected mice.
  
  
  CONCLUSIONS
  The results showed that the root bark extract possesses a potential antiplasmodial activity, which can be exploited for the possible development of new antimalarial agent.
authors.forename: Godwin C
authors.initials: GC
authors.lastname: Akuodor
authors.forename: David-Oku
authors.initials: DO
authors.lastname: Essien
authors.forename: Julie A
authors.initials: JA
authors.lastname: Nkorroh
authors.forename: Augustine D
authors.initials: AD
authors.lastname: Essien
authors.forename: Effiong E
authors.initials: EE
authors.lastname: Nkanor
authors.forename: Mercy N
authors.initials: MN
authors.lastname: Ezeunala
authors.forename: Kingsley C
authors.initials: KC
authors.lastname: Chilaka
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D008288:Malaria / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D051379:Mice; D024301:Plant Bark; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D010962:Plasmodium berghei / Q000187:drug effects* / Q000502:physiology
chemical_list: D000962:Antimalarials; D010936:Plant Extracts; D000431:Ethanol