title: [Analysis of the influence of gender on the clinicopathological features and prognosis of pancreatic cystic neoplasms].
abstract: Objective:To compare the clinicopathological features and prognosis of pancreatic cystic neoplasms (PCN) between male and female patients.Methods:A total of 325 patients with histological confirmed PCN from January 2010 to October 2015 were enrolled. The clinicopathological features, laboratory examination, imaging features, treatment and prognosis were analyzed.Results:Of the 325 patients diagnosed as PCN, 104 were male and 221 were female. The average age of male patients was significantly higher than that of female patients (55.0±12.7 vs 47.9±13.4 years,P<0.001), however, the average tumor size of male patients was smaller than that of female patients (3.9±2.7 vs 4.9±3.0 cm,P=0.004). The location of PCN in male patients was predominantly located at pancreatic head and neck, and majority of male patients were mucinous cystic neoplasms. 1-year, 3-year and 5-year survival rates of patients with PCN were 98.5%, 92.6%, and 87.5%, respectively. 1-year, 3-year and 5-year survival rates of male patients were 97.8%, 84.9%, and 77.8%, however, those of female patients were 98.8%, 96.5%, and 92.2%, respectively. Female patients had better prognosis than male patients (χ2=5.543,P=0.019). Elevated CA19-9 (χ2=3.843,P=0.050), perineuronal invasion (χ2=6.250,P=0.012) and lymph node metastasis (χ2=4.529,P=0.033) were important prognostic factors for malignant mucinous cystic neoplasm.Conclusions:Male patients had low incidence of PCN, and were more common for mucinous cystic neoplasm. The long-term outcome of malignant PCN was poor. Even with complete resection, male patients still had worse prognosis. Close follow-up is recommended especially for male patients.
authors.affiliation: Department of Hepatobiliary Surgery, People's Liberation Army General Hospital, Beijing 100853, China.
authors.forename: M Y
authors.initials: MY
authors.lastname: Xu
authors.forename: X J
authors.initials: XJ
authors.lastname: Shi
authors.forename: L
authors.initials: L
authors.lastname: He
authors.forename: F
authors.initials: F
authors.lastname: Lu
authors.forename: M Y
authors.initials: MY
authors.lastname: Chen
authors.forename: H G
authors.initials: HG
authors.lastname: Wang
authors.forename: S C
authors.initials: SC
authors.lastname: Lu
mesh_terms: D018395:CA-19-9 Antigen; D005260:Female; D006801:Humans; D015994:Incidence; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009375:Neoplasms, Glandular and Epithelial; D010179:Pancreas; D010190:Pancreatic Neoplasms; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate
chemical_list: D018395:CA-19-9 Antigen