title: Hepatoprotective triterpenoids and lignans from the stems of Schisandra pubescens.
abstract: One new triterpenoid (1) and 13 known compounds (2-14) were isolated from Schisandra pubescens stems. The structure of the new compound was established on the basis of 1D/2D NMR and HRESIMS spectroscopic analyses. The isolated compounds were evaluated for their hepatoprotective activities against D-GalN-induced cell injury in QSG7701 cells. Compounds 1, 13 and 14 at 10 μM showed hepatoprotective activities, with survival rates of 60.5, 50.4 and 48.9%, respectively.
authors.affiliation: a College of Pharmaceutical Sciences, Key Laboratory of Luminescent and Real-Time Analytical Chemistry, Ministry of Education , Southwest University , Chongqing , P.R. China.
authors.forename: Guo-Wei
authors.initials: GW
authors.lastname: Wang
authors.affiliation: a College of Pharmaceutical Sciences, Key Laboratory of Luminescent and Real-Time Analytical Chemistry, Ministry of Education , Southwest University , Chongqing , P.R. China.
authors.forename: Li-Qing
authors.initials: LQ
authors.lastname: Deng
authors.affiliation: a College of Pharmaceutical Sciences, Key Laboratory of Luminescent and Real-Time Analytical Chemistry, Ministry of Education , Southwest University , Chongqing , P.R. China.
authors.forename: You-Ping
authors.initials: YP
authors.lastname: Luo
authors.affiliation: b School of Life Sciences , Southwest University , Chongqing , P.R. China.
authors.forename: Zhi-Hua
authors.initials: ZH
authors.lastname: Liao
authors.affiliation: a College of Pharmaceutical Sciences, Key Laboratory of Luminescent and Real-Time Analytical Chemistry, Ministry of Education , Southwest University , Chongqing , P.R. China.
authors.forename: Min
authors.initials: M
authors.lastname: Chen
mesh_terms: D002460:Cell Line; D004353:Drug Evaluation, Preclinical / Q000379:methods; D022781:Hepatocytes / Q000187:drug effects; D006801:Humans; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D018547:Plant Stems / Q000737:chemistry; D020011:Protective Agents / Q000737:chemistry* / Q000494:pharmacology*; D032141:Schisandra / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000494:pharmacology
chemical_list: C000625985:11beta-hydroxylkadsuphilactone A; D017705:Lignans; D020011:Protective Agents; D014315:Triterpenes
keywords: Schisandra pubescens; hepatoprotective activities; lignans; triterpenoids