title: Coordination-Induced Assembly of Intelligent Polysaccharide-Based Phototherapeutic Nanoparticles for Cancer Treatment.
abstract: Smart polysaccharide-based anticancer phototherapeutic nanoparticles are prepared via a coordination-induced assembly process. Upon irradiated with a near infrared laser, the nanoparticles are not only able to simultaneously generate reactive oxygen species and hyperthermia that ablate tumors, but also possess tumor microenvironment-responsive off/on near infrared fluorescence and enhancement in photothermal effect, making them promising theranostic platform of cancer.
authors.affiliation: State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai, 200433, P. R. China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Tian
authors.affiliation: State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai, 200433, P. R. China.
authors.forename: Ranran
authors.initials: R
authors.lastname: Guo
authors.affiliation: Department of Chemistry, Fudan University, Shanghai, 200433, P. R. China.
authors.forename: Yajun
authors.initials: Y
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai, 200433, P. R. China.
authors.forename: Wuli
authors.initials: W
authors.lastname: Yang
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry*; D045744:Cell Line, Tumor; D005334:Fever / Q000188:drug therapy; D005453:Fluorescence; D006801:Humans; D007259:Infrared Rays; D061986:MCF-7 Cells; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry*; D009369:Neoplasms / Q000188:drug therapy*; D010789:Phototherapy / Q000379:methods; D011134:Polysaccharides / Q000008:administration & dosage* / Q000737:chemistry*; D017382:Reactive Oxygen Species / Q000737:chemistry; D000068936:Theranostic Nanomedicine / Q000379:methods; D059016:Tumor Microenvironment / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D011134:Polysaccharides; D017382:Reactive Oxygen Species
keywords: hyaluronic acid; multimodal imaging; photodynamic therapy; photosensitizers; photothermal therapy