title: A Powerful CD8+T-Cell Stimulating D-Tetra-Peptide Hydrogel as a Very Promising Vaccine Adjuvant.
abstract: A novel vaccine adjuvant based on a supramolecular hydrogel of a D-tetra-peptide is reported. Antigens can be easily incorporated into the hydrogel by a vortex or by gently shaking before injection. The vaccines can stimulate strong CD8+ T-cell responses, which significantly inhibits tumor growth. This novel adjuvant is expected to enable a wide range of sub-unit vaccines and help the production of antibodies.
authors.affiliation: Institute of Biomaterials and Engineering, Wenzhou Medical University, Wenzhou Institute of Biomaterials and Engineering, CNITECH, CAS, Wenzhou, 325035, P. R. China.
authors.forename: Zichao
authors.initials: Z
authors.lastname: Luo
authors.affiliation: State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, 610041, P. R. China.
authors.forename: Qinjie
authors.initials: Q
authors.lastname: Wu
authors.affiliation: State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Key Laboratory of Bioactive Materials, Ministry of Education, Nankai University and Collaborative Innovation Center of Chemical Science and Engineering, Tianjin, 300071, P. R. China.
authors.forename: Chengbiao
authors.initials: C
authors.lastname: Yang
authors.affiliation: State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Key Laboratory of Bioactive Materials, Ministry of Education, Nankai University and Collaborative Innovation Center of Chemical Science and Engineering, Tianjin, 300071, P. R. China.
authors.forename: Huaimin
authors.initials: H
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, 610041, P. R. China.
authors.forename: Tao
authors.initials: T
authors.lastname: He
authors.affiliation: State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Key Laboratory of Bioactive Materials, Ministry of Education, Nankai University and Collaborative Innovation Center of Chemical Science and Engineering, Tianjin, 300071, P. R. China.
authors.forename: Youzhi
authors.initials: Y
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Key Laboratory of Bioactive Materials, Ministry of Education, Nankai University and Collaborative Innovation Center of Chemical Science and Engineering, Tianjin, 300071, P. R. China.
authors.forename: Zhongyan
authors.initials: Z
authors.lastname: Wang
authors.affiliation: School of Ophthalmology & Optometry and Eye hospital, Wenzhou Medical University, Wenzhou Institute of Biomaterials and Engineering, CNITECH, CAS, Wenzhou, 325035, P. R. China.
authors.forename: Hao
authors.initials: H
authors.lastname: Chen
authors.affiliation: School of Ophthalmology & Optometry and Eye hospital, Wenzhou Medical University, Wenzhou Institute of Biomaterials and Engineering, CNITECH, CAS, Wenzhou, 325035, P. R. China.
authors.forename: Xingyi
authors.initials: X
authors.lastname: Li
authors.affiliation: State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, 610041, P. R. China.
authors.forename: Changyang
authors.initials: C
authors.lastname: Gong
authors.affiliation: State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Key Laboratory of Bioactive Materials, Ministry of Education, Nankai University and Collaborative Innovation Center of Chemical Science and Engineering, Tianjin, 300071, P. R. China.
authors.forename: Zhimou
authors.initials: Z
authors.lastname: Yang
mesh_terms: D000276:Adjuvants, Immunologic; D018414:CD8-Positive T-Lymphocytes; D020100:Hydrogels; D010455:Peptides; D014612:Vaccines
chemical_list: D000276:Adjuvants, Immunologic; D020100:Hydrogels; D010455:Peptides; D014612:Vaccines
keywords: adjuvants; cancer therapy; hydrogels; peptides; vaccines