title: Nanobiomaterials for neural regeneration.
abstract: Diseases and disorders associated with nervous system such as injuries by trauma and neurodegeneration are shown to be one of the most serious problems in medicine, requiring innovative strategies to trigger and enhance the nerve regeneration. Tissue engineering aims to provide a highly biomimetic environment by using a combination of cells, materials and suitable biological cues, by which the lost body part may be regenerated or even fully rebuilt. Electrospinning, being able to produce extracellular matrix (ECM)-like nanostructures with great flexibility in design and choice of materials, have demonstrated their great potential for fabrication of nerve tissue engineered scaffolds. The review here begins with a brief description of the anatomy of native nervous system, which provides basic knowledge and ideas for the design of nerve tissue scaffolds, followed by five main parts in the design of electrospun nerve tissue engineered scaffolds including materials selection, structural design,in vitrobioreactor, functionalization and cellular support. Performances of biomimetic electrospun nanofibrous nerve implant devices are also reviewed. Finally, future directions for advanced electrospun nerve tissue engineered scaffolds are discussed.
authors.affiliation: Center for Nanofibers and Nanotechnology, Department of Mechanical Engineering, Faculty of Engineering, National University of Singapore, Singapore, Singapore.
authors.forename: Nuan
authors.initials: N
authors.lastname: Chen
authors.affiliation: Center for Nanofibers and Nanotechnology, Department of Mechanical Engineering, Faculty of Engineering, National University of Singapore, Singapore, Singapore.
authors.forename: Lingling
authors.initials: L
authors.lastname: Tian
authors.affiliation: Department of Biomedical Engineering, College of Life Science and Technology, Jinan University, Guangzhou, Guangdong Province, China.
authors.forename: Liumin
authors.initials: L
authors.lastname: He
authors.affiliation: Center for Nanofibers and Nanotechnology, Department of Mechanical Engineering, Faculty of Engineering, National University of Singapore, Singapore, Singapore; Guangdong-Hongkong-Macau Institute of CNS Regeneration (GHMICR), Jinan University, Guangzhou, Guangdong Province, China.
authors.forename: Seeram
authors.identifier: 0000-0001-8479-8686
authors.initials: S
authors.lastname: Ramakrishna
keywords: contact guidance; electrospun scaffold; nanofibers; nanostructured materials; nerve regeneration; tissue engineering