title: TLE1 function and therapeutic potential in cancer.
abstract: Groucho (Gro)/Transducin-like enhancer of split (TLE) family proteins act as co-repressors of many transcription factors, and are involved in key signaling pathways. TLE1 negatively regulates inflammation and has potential roles in various diseases, including cancer. Previous studies suggest TLE1 could be used as a diagnostic marker and is a possible therapeutic target in various malignancies. It is therefore important to elucidate the mechanisms underlying TLE1 function during cancer initiation and metastasis. In this review, we highlight the functions of TLE1 in cancer and explore targeted approaches for cancer diagnosis and treatment. In particular, we discuss the TLE1 function in pancreatic cancer.
authors.affiliation: Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Da
authors.initials: D
authors.lastname: Yuan
authors.affiliation: Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.
authors.forename: Xue
authors.initials: X
authors.lastname: Yang
authors.affiliation: Department of Pediatric Cardiac Surgery, Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Zhenpeng
authors.initials: Z
authors.lastname: Yuan
authors.affiliation: Institute of Medical Information, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.
authors.forename: Yanqing
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Junchao
authors.initials: J
authors.lastname: Guo
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D056970:Co-Repressor Proteins; D006801:Humans; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism; D012097:Repressor Proteins / Q000235:genetics* / Q000378:metabolism*
chemical_list: D056970:Co-Repressor Proteins; D012097:Repressor Proteins; C499043:TLE1 protein, human
keywords: pancreatic cancer; transducin-like enhancer of split 1; tumor