title: [Agomelatine (valdoxan) in treatment of endogenous depression in day patient department].
abstract: OBJECTIVE
  Naturalistic psychopharmacological study of efficacy and tolerability of agomelatine (valdoxan) in treatment of endogenous depressions (in the framework of schizophrenia, schizoaffective and bipolar disorder) in day patient department.
  
  
  METHODS
  Study sample consisted of 37 patient (59.4% female, mean age 41.6±3.7 years).
  
  
  CONCLUSIONS
  CDS total score significantly reduced after 8 weeks of treatment 44.9% compared to baseline (р<0.001); HAM-D total score decreased on 51.3% compared to baseline (р<0.001). The proportion of responders at the 8th week of treatment was 54.1%. Agomelatine (valdoxan) had favorable safety profile. Follow-up study (up to 24 months) showed stable antidepressive effect and good tolerability profile of agomelatine (valdoxan). There was no withdrawal syndrome after treatment discontinuation.
authors.affiliation: Psychiatric Hospital #13, Moscow, Russia.
authors.forename: E V
authors.initials: EV
authors.lastname: Chernova
authors.affiliation: Psychiatric Hospital #13, Moscow, Russia.
authors.forename: O V
authors.initials: OV
authors.lastname: Kozhechkina
authors.affiliation: Psychiatric Hospital #13, Moscow, Russia; People's Friendship University of Russia, Moscow, Russia.
authors.forename: A Yu
authors.initials: AY
authors.lastname: Ter-Israelyan
authors.affiliation: People's Friendship University of Russia, Moscow, Russia.
authors.forename: V E
authors.initials: VE
authors.lastname: Medvedev
mesh_terms: D000081:Acetamides / Q000627:therapeutic use*; D000328:Adult; D000928:Antidepressive Agents / Q000627:therapeutic use*; D001714:Bipolar Disorder / Q000150:complications*; D003866:Depressive Disorder / Q000188:drug therapy* / Q000209:etiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000150:complications*; D016896:Treatment Outcome; D009281:Naphthalenes
chemical_list: D000081:Acetamides; D000928:Antidepressive Agents; C084711:agomelatine; D009281:Naphthalenes