title: The BLUEPRINT Data Analysis Portal.
abstract: The impact of large and complex epigenomic datasets on biological insights or clinical applications is limited by the lack of accessibility by easy, intuitive, and fast tools. Here, we describe an epigenomics comparative cyber-infrastructure (EPICO), an open-access reference set of libraries to develop comparative epigenomic data portals. Using EPICO, large epigenome projects can make available their rich datasets to the community without requiring specific technical skills. As a first instance of EPICO, we implemented the BLUEPRINT Data Analysis Portal (BDAP). BDAP provides a desktop for the comparative analysis of epigenomes of hematopoietic cell types based on results, such as the position of epigenetic features, from basic analysis pipelines. The BDAP interface facilitates interactive exploration of genomic regions, genes, and pathways in the context of differentiation of hematopoietic lineages. This work represents initial steps toward broadly accessible integrative analysis of epigenomic data across international consortia. EPICO can be accessed at https://github.com/inab, and BDAP can be accessed at http://blueprint-data.bsc.es.
authors.affiliation: Structural Biology and BioComputing Programme, Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain; Spanish Bioinformatics Institute INB-ISCIII ES-ELIXIR, Madrid 28029, Spain.
authors.forename: José María
authors.initials: JM
authors.lastname: Fernández
authors.affiliation: Structural Biology and BioComputing Programme, Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain; Spanish Bioinformatics Institute INB-ISCIII ES-ELIXIR, Madrid 28029, Spain.
authors.forename: Victor
authors.initials: V
authors.lastname: de la Torre
authors.affiliation: European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
authors.forename: David
authors.initials: D
authors.lastname: Richardson
authors.affiliation: Spanish Bioinformatics Institute INB-ISCIII ES-ELIXIR, Madrid 28029, Spain; Barcelona Supercomputing Center (BSC), Joint BSC-CRG-IRB, Research Program in Computational Biology, BSC - CRG - IRB, Barcelona 08028, Spain.
authors.forename: Romina
authors.initials: R
authors.lastname: Royo
authors.affiliation: Barcelona Supercomputing Center (BSC), Joint BSC-CRG-IRB, Research Program in Computational Biology, BSC - CRG - IRB, Barcelona 08028, Spain.
authors.forename: Montserrat
authors.initials: M
authors.lastname: Puiggròs
authors.affiliation: Barcelona Supercomputing Center (BSC), Joint BSC-CRG-IRB, Research Program in Computational Biology, BSC - CRG - IRB, Barcelona 08028, Spain.
authors.forename: Valentí
authors.initials: V
authors.lastname: Moncunill
authors.affiliation: Barcelona Supercomputing Center (BSC), Joint BSC-CRG-IRB, Research Program in Computational Biology, BSC - CRG - IRB, Barcelona 08028, Spain.
authors.forename: Stamatina
authors.initials: S
authors.lastname: Fragkogianni
authors.affiliation: European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
authors.forename: Laura
authors.initials: L
authors.lastname: Clarke
authors.affiliation: http://www.blueprint-epigenome.eu/.
authors.affiliation: European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
authors.forename: Paul
authors.initials: P
authors.lastname: Flicek
authors.affiliation: Structural Biology and BioComputing Programme, Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain.
authors.forename: Daniel
authors.initials: D
authors.lastname: Rico
authors.affiliation: Barcelona Supercomputing Center (BSC), Joint BSC-CRG-IRB, Research Program in Computational Biology, BSC - CRG - IRB, Barcelona 08028, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona 08010, Spain.
authors.forename: David
authors.initials: D
authors.lastname: Torrents
authors.affiliation: Structural Biology and BioComputing Programme, Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain. Electronic address: ecarrillo@cnio.es.
authors.forename: Enrique
authors.initials: E
authors.lastname: Carrillo de Santa Pau
authors.affiliation: Structural Biology and BioComputing Programme, Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain; Spanish Bioinformatics Institute INB-ISCIII ES-ELIXIR, Madrid 28029, Spain. Electronic address: valencia@cnio.es.
authors.forename: Alfonso
authors.initials: A
authors.lastname: Valencia
mesh_terms: D002454:Cell Differentiation; D044127:Epigenesis, Genetic; D057890:Epigenomics; D016678:Genome; D020407:Internet; D012984:Software; D014584:User-Computer Interface
keywords: BLUEPRINT Data Analysis Portal; BLUEPRINT epigenomes; International Human Epigenomes Consortium; bioinformatics; cyber-infrastructure; epigenomic data mining tools; epigenomic data visualization; epigenomics; hematopoiesis; leukemia