title: Clinical outcomes of a cohort of patients with central nervous system metastases from thyroid cancer.
abstract: BACKGROUND
  Metastases to central nervous system (M1-CNS) are rarely reported in thyroid cancer (TC) patients. We aimed to characterize patients with M1-CNS from TC followed in our department.
  
  
  METHODS
  Review of the medical records of 27 patients with TC-related M1-CNS.
  
  
  RESULTS
  Mean age at TC diagnosis was 56.9 ± 19.1 years. Papillary TC (55.6%) was the commonest histological type, followed by poorly differentiated (18.5%), medullary (11.1%), follicular (7.4%) and Hürthle cell (7.4%) carcinomas. Angioinvasion and extrathyroidal extension were observed in a high number of patients. At M1-CNS diagnosis, other distant metastases were already present in 77.8% of the patients. Treatment directed to M1-CNS was offered to 20 (74%) patients: 1 was submitted to surgery, 18 to radiotherapy (either whole-brain radiotherapy or stereotaxic radiosurgery or both) and 4 to surgery and radiotherapy. Four patients received cytotoxic chemotherapy and one was submitted to131I. Median survival since M1-CNS detection was 5.0 months. The only factor associated with better survival was surgery to brain metastases (P = 0.012).
  
  
  CONCLUSIONS
  The management of these patients is very challenging given the inexistence of effective treatments, except for brain surgery in selected cases.
authors.affiliation: Endocrinology DepartmentInstituto Português de Oncologia de Lisboa, Francisco Gentil, Lisboa, Portugal joanasimoespereira@gmail.com.
authors.forename: Joana
authors.initials: J
authors.lastname: Simões-Pereira
authors.affiliation: Endocrinology DepartmentInstituto Português de Oncologia de Lisboa, Francisco Gentil, Lisboa, Portugal.
authors.forename: Daniel
authors.initials: D
authors.lastname: Macedo
authors.affiliation: Endocrinology DepartmentInstituto Português de Oncologia de Lisboa, Francisco Gentil, Lisboa, Portugal.
authors.forename: Maria João
authors.initials: MJ
authors.lastname: Bugalho
keywords: brain metastases; brain surgery; central nervous system; thyroid cancer