title: Effect of oxytocin infusion on reducing the blood loss during abdominal myomectomy: a double-blind randomised controlled trial.
abstract: To assess the effectiveness and safety of oxytocin to reduce blood loss during abdominal myomectomy.
  
  
  
  Double-blind randomised controlled trial.
  
  
  
  Obstetrics and Gynecologic University Medical Centre.
  
  
  
  Eighty healthy women candidates for abdominal myomectomy.
  
  
  
  Women were randomly assigned to two groups. In the study group (n = 40) oxytocin 30 IU in 500 ml normal saline; and in the placebo group (n = 40) pure normal saline was administered during myomectomy. The main outcome measures were peri-operative blood loss and rates of blood transfusion.
  
  
  
  Estimated intra-operative blood loss.
  
  
  
  Estimated intra-operative blood loss in the study group (189.5 ± 16.72 ml) was significantly lower than the placebo group (692.25 ± 89.93 ml) (95% CI 672.54-711.96; P < 0.0001).The need for blood transfusion was significantly lower in the study group. Blood transfusions were required for three (7.5%) women in the study group and 10 (25%) women in the placebo group (95% CI 15.5-34.5; P < 0.001).
  
  
  
  Intra-operative oxytocin infusion appears to be safe and effective in decreasing blood loss during abdominal myomectomy.
  
  
  
  Intra-operative oxytocin is effective in decreasing blood loss during abdominal myomectomy.
authors.affiliation: Women's Reproductive Health Research Center, Al-Zahra Hospital, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: S
authors.initials: S
authors.lastname: Atashkhoei
authors.affiliation: Women's Reproductive Health Research Center, Al-Zahra Hospital, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: S
authors.initials: S
authors.lastname: Fakhari
authors.affiliation: Women's Reproductive Health Research Center, Al-Zahra Hospital, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: H
authors.initials: H
authors.lastname: Pourfathi
authors.affiliation: Women's Reproductive Health Research Center, Al-Zahra Hospital, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: E
authors.initials: E
authors.lastname: Bilehjani
authors.affiliation: Women's Reproductive Health Research Center, Al-Zahra Hospital, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: P M
authors.initials: PM
authors.lastname: Garabaghi
authors.affiliation: Women's Reproductive Health Research Center, Al-Zahra Hospital, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: A
authors.initials: A
authors.lastname: Asiaei
mesh_terms: D000005:Abdomen / Q000601:surgery; D000328:Adult; D016063:Blood Loss, Surgical / Q000517:prevention & control*; D001803:Blood Transfusion / Q000706:statistics & numerical data; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007263:Infusions, Parenteral; D007889:Leiomyoma / Q000601:surgery; D010120:Oxytocics / Q000008:administration & dosage*; D010121:Oxytocin / Q000008:administration & dosage*; D016896:Treatment Outcome; D063186:Uterine Myomectomy / Q000009:adverse effects* / Q000379:methods; D014594:Uterine Neoplasms / Q000601:surgery
chemical_list: D010120:Oxytocics; D010121:Oxytocin
keywords: Abdominal myomectomy; blood transfusion; intra-operative blood loss; oxytocin