title: Paradoxical thinning of the retinal nerve fiber layer after reversal of cupping: A case report of primary infantile glaucoma.
abstract: The circumpapillary retinal nerve fiber layer (RNFL) thickness was assessed by spectral domain optical coherent tomography (SD-OCT) before and after surgical reduction of intraocular pressure in an eye with primary infantile glaucoma. In this case, a postoperative reduction of cupping and a subsequent increase in neuroretinal rim area is associated with a paradoxical thinning of the RNFL. This is the first-known characterization of cupping reversal using SD-OCT.
authors.affiliation: Vanderbilt Eye Institute, Nashville, TN, USA.
authors.forename: Ta Chen
authors.initials: TC
authors.lastname: Chang
authors.affiliation: Department of Ophthalmology, University of Minnesota, Minneapolis, MN; University of Miami, Bascom Palmer Eye Institute, Miami FL, USA.
authors.forename: Alana L
authors.initials: AL
authors.lastname: Grajewski
mesh_terms: D002675:Child, Preschool; D005260:Female; D005902:Glaucoma, Open-Angle / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D007429:Intraocular Pressure; D009412:Nerve Fibers / Q000473:pathology*; D009898:Optic Disk / Q000473:pathology*; D009901:Optic Nerve Diseases / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D012165:Retinal Ganglion Cells / Q000473:pathology*; D041623:Tomography, Optical Coherence; D014065:Tonometry, Ocular; D014130:Trabeculectomy / Q000009:adverse effects*