title: Genome editing: progress and challenges for medical applications.
abstract: The development of the CRISPR-Cas platform for genome editing has greatly simplified the process of making targeted genetic modifications. Applications of genome editing are expected to have a substantial impact on human therapies through the development of better animal models, new target discovery, and direct therapeutic intervention.
authors.affiliation: Department of Biochemistry, University of Utah School of Medicine, 15 N. Medical Drive East, Room 4100, Salt Lake City, UT, 84112-5650, USA. dana@biochem.utah.edu.
authors.forename: Dana
authors.identifier: 0000-0002-3241-3331
authors.initials: D
authors.lastname: Carroll
mesh_terms: D000818:Animals; D064113:CRISPR-Cas Systems / Q000235:genetics*; D004247:DNA / Q000032:analysis; D017353:Gene Deletion; D000072669:Gene Editing; D005818:Genetic Engineering; D015316:Genetic Therapy / Q000379:methods*; D016678:Genome; D006801:Humans; D009154:Mutation; D017393:RNA Editing
chemical_list: D004247:DNA