title: Pinus massoniana Bark Extract: Structure-Activity Relationship and Biomedical Potentials.
abstract: Proanthocyanidins (PAs) belong to the condensed tannin subfamily of natural flavonoids. Recent studies have shown that the main bioactive compounds of Pinus massoniana bark extract (PMBE) are PAs, especially the proanthocyanidins B series, which play important roles in cell cycle arrest, apoptosis induction and migration inhibition of cancer cells in vivo and in vitro. PA-Bs are mixtures of oligomers and polymers composed of flavan-3-ol, and the relationship between their structure and corresponding biomedical potentials is summarized in this paper. The hydroxyl at certain positions or the linkage between different carbon atoms of different rings determines or affects their anti-oxidant and free radical scavenging bioactivities. The degree of polymerization and the water solubility of the reaction system also influence their biomedical potential. Taken together, PMBE has a promising future in clinical drug development as a candidate anticancer drug and as a food additive to prevent tumorigenesis. We hope this review will encourage interested researchers to conduct further preclinical and clinical studies to evaluate the anticancer activities of PMBE, its active constituents and their derivatives.
authors.affiliation: ‡ Department of Regenerative Medicine, Tongji University School of Medicine, Shanghai 200092, P.R. China.
authors.forename: Jiao
authors.initials: J
authors.lastname: Feng
authors.affiliation: ‡ Department of Regenerative Medicine, Tongji University School of Medicine, Shanghai 200092, P.R. China.
authors.forename: Xiao-Lu
authors.initials: XL
authors.lastname: Zhang
authors.affiliation: ‡ Department of Regenerative Medicine, Tongji University School of Medicine, Shanghai 200092, P.R. China.
authors.forename: Ying-Ya
authors.initials: YY
authors.lastname: Li
authors.affiliation: * Key Laboratory of Arrhythmias, Ministry of Education (Tongji University), Shanghai 200120, P.R. China.|† Institute of Medical Genetics, Tongji University School of Medicine, Shanghai 200092, P.R. China.|‡ Department of Regenerative Medicine, Tongji University School of Medicine, Shanghai 200092, P.R. China.
authors.forename: Ying-Yu
authors.initials: YY
authors.lastname: Cui
authors.affiliation: * Key Laboratory of Arrhythmias, Ministry of Education (Tongji University), Shanghai 200120, P.R. China.|† Institute of Medical Genetics, Tongji University School of Medicine, Shanghai 200092, P.R. China.|§ Department of Pathology and Pathophysiology, Tongji University School of Medicine, Shanghai 200092, P.R. China.|¶ Department of Cardiology, East Hospital, Tongji University School of Medicine, Shanghai 200120, P.R. China.
authors.forename: Yi-Han
authors.initials: YH
authors.lastname: Chen
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D059447:Cell Cycle Checkpoints / Q000187:drug effects; D055598:Chemical Phenomena; D016166:Free Radical Scavengers; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000517:prevention & control; D008517:Phytotherapy; D028223:Pinus / Q000737:chemistry*; D024301:Plant Bark / Q000737:chemistry; D044945:Proanthocyanidins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D013329:Structure-Activity Relationship
chemical_list: D000890:Anti-Infective Agents; D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants; D016166:Free Radical Scavengers; D044945:Proanthocyanidins
keywords: Anti-oxidant; Anticancer Drug Lead; Pinus massoniana Bark Extract; Proanthocyanidins; Review; Structure–Activity Relationship