title: Does Local Ibandronate and/or Pamidronate Delivery Enhance Osseointegration? A Systematic Review.
abstract: OBJECTIVE
  To our knowledge from indexed literature, the present study is the first one to systematically review the influence of local delivery of pamidronate (PAM) and/or ibandronate (IBA) on osseointegration enhancement. The aim of the present systematic review was to assess the efficacy of IBA and/or PAM local delivery (topically or coating on implants surfaces) in promoting osseointegration.
  
  
  METHODS
  To address the focused question, "Does local IBA and/or PAM delivery enhances osseointegration?," indexed databases were searched without time or language restrictions up to and including May 2016 using various combinations of the following keywords: "pamidronate," "ibandronate," "bisphosphonates," "osseointegration," and "topical administration." Letters to the Editor, historic reviews, commentaries, case series, and case reports were excluded.
  
  
  RESULTS
  Fifteen studies were included. Fourteen studies were performed in animals and 2 were clinical trials. One study reported an experimental model and a clinical trial in the same publication. Results from 12 experimental studies and 2 clinical studies reported improved biomechanical properties and/or osseointegration around implants with PAM and/or IBA. Two experimental studies showed that PAM and/or IBA did not improve osseointegration.
  
  
  CONCLUSIONS
  On experimental grounds, local IBA and/or PAM delivery seems to enhance osseointegration; however, from a clinical perspective, further randomized control trials are needed to assess the effectiveness of IBA and PAM in promoting osseointegration around dental implants.
authors.affiliation: Department of General Dentistry, Eastman Institute for Oral Health, University of Rochester, Rochester, NY.
authors.forename: Sergio Varela
authors.initials: SV
authors.lastname: Kellesarian
authors.affiliation: Department of Prosthetic Dental Sciences, College of Dentistry, King Saud University, Riyadh, Saudi Arabia.
authors.forename: Tariq
authors.initials: T
authors.lastname: Abduljabbar
authors.affiliation: Department of Prosthetic Dental Sciences, College of Dentistry, King Saud University, Riyadh, Saudi Arabia.
authors.forename: Fahim
authors.initials: F
authors.lastname: Vohra
authors.affiliation: Department of Engineering, Capital College, Penn State University Harrisburg, Middletown, PA.
authors.forename: Elham
authors.initials: E
authors.lastname: Gholamiazizi
authors.affiliation: Department of General Dentistry, Eastman Institute for Oral Health, University of Rochester, Rochester, NY.
authors.forename: Hans
authors.initials: H
authors.lastname: Malmstrom
authors.affiliation: Department of Oral Surgery and Implant Dentistry, Dental School, Johann Wolfgang Goethe, University of Frankfurt, Germany.|Department of Periodontology, School of Dental Medicine, Stony Brook University, Stony Brook, NY.
authors.forename: Georgios E
authors.initials: GE
authors.lastname: Romanos
authors.affiliation: Department of General Dentistry, Eastman Institute for Oral Health, University of Rochester, Rochester, NY.
authors.forename: Fawad
authors.initials: F
authors.lastname: Javed
mesh_terms: D000287:Administration, Topical; D050071:Bone Density Conservation Agents / Q000008:administration & dosage*; D006801:Humans; D000077557:Ibandronic Acid / Q000008:administration & dosage*; D016348:Osseointegration / Q000187:drug effects*; D000077268:Pamidronate / Q000008:administration & dosage*
chemical_list: D050071:Bone Density Conservation Agents; D000077268:Pamidronate; D000077557:Ibandronic Acid
keywords: Osseointegration; bisphosphonates; ibandronate; implants; pamidronate; topical administration