title: Effect of solvents on forming poly(butyl-2-cyanoacrylate) encapsulated paeonol nanocapsules.
abstract: The effect of ethanol or acetone, as oil phase solvents, upon the form of paeonol-loaded poly(butyl-2-cyanoacrylate) encapsulated nanocapsules (Pae@PNCs) by interfacial spontaneously polymerization were investigated. Pae@PNCs characterizations including morphology, radius distribution, polydispersity index (PDI), particle size, zeta potential, entrapment efficiency (EE%), drug loading (DL%) and in vitro paeonol release kinetics were evaluated. Results show that 100% acetone have a significant effect on forming nanocapsules, which showed the smaller size (168.3 ± 6.76 nm) under scanning electron microscopy (SEM) and one radius distribution by the particle size analyser. The data showed that using 100% acetone to prepare Pae@PNCs was leading to smaller particle size and lower polydispersity index (PDI), higher zeta potential, better EE (%) and perfect DL (%), which is linear decrease in radius (r2= 0.939) and PDI (r2= 0.974) and linear increase EE% (r2= 0.9879) and DL% (r2= 0.9892) with the acetone concentration (range 10-100% v/v). Paeonol encapsulated into and adhered on PNCs were confirmed by UV-Visible spectra (UV-Vis), Fourier transform infrared spectroscopy (FTIR) and Differential scanning calorimetry (DSC). Drug release behavior in vitro showed that 100% acetone as solvents on developing Pae@PNCs have greater advantages in controlling and prolonging paeonol release. Results demonstrated that solvents have a significant influence on forming Pae@PNCs.
authors.affiliation: a School of Life Sciences, Anhui Agricultural University , Hefei , China.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Yao
authors.affiliation: a School of Life Sciences, Anhui Agricultural University , Hefei , China.
authors.forename: Decheng
authors.initials: D
authors.lastname: Zeng
authors.affiliation: a School of Life Sciences, Anhui Agricultural University , Hefei , China.
authors.forename: Yangxin
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: a School of Life Sciences, Anhui Agricultural University , Hefei , China.
authors.forename: Dongdong
authors.initials: D
authors.lastname: Sun
authors.affiliation: a School of Life Sciences, Anhui Agricultural University , Hefei , China.
authors.forename: Endong
authors.initials: E
authors.lastname: Yang
authors.affiliation: a School of Life Sciences, Anhui Agricultural University , Hefei , China.
authors.forename: Haiping
authors.initials: H
authors.lastname: Liu
authors.affiliation: a School of Life Sciences, Anhui Agricultural University , Hefei , China.
authors.forename: Feng
authors.initials: F
authors.lastname: Guo
authors.affiliation: a School of Life Sciences, Anhui Agricultural University , Hefei , China.
authors.forename: Weiyun
authors.initials: W
authors.lastname: Wang
mesh_terms: D000098:Acetophenones / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D004659:Enbucrilate / Q000737:chemistry*; D007700:Kinetics; D053769:Nanocapsules / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry*
chemical_list: D000098:Acetophenones; D004337:Drug Carriers; D053769:Nanocapsules; D012997:Solvents; C013638:paeonol; D004659:Enbucrilate
keywords: Solvents; characterization; nanocapsules; paeonol; poly(butyl-2-cyanoacrylate)