title: Retinol dehydrogenase 13 deficiency diminishes carbon tetrachloride-induced liver fibrosis in mice.
abstract: Retinol dehydrogenase 13 (RDH13) is a mitochondrion-localized member of the short-chain dehydrogenases/reductases (SDRs) superfamily that participates in metabolism of some compounds. Rdh13 mRNA is most highly expressed in mouse liver. Rdh13 deficiency reduces the extent of liver injury and fibrosis, reduces hepatic stellate cell (HSC) activation, attenuates collagen I (II), tissue inhibitor of metalloproteinase 1 (TIMP-1) and transforming growth factor beta 1 (Tgf-β1) expression. The results indicate an important role of Rdh13 and suggest RDH13 as a possible new therapeutic target for CCl4-induced fibrosis.
authors.affiliation: State Key Laboratory of Medical Genomics, Research Center for Experimental Medicine, Shanghai Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, 200025, China; Model Organism Division, E-Institutes of Shanghai Jiao Tong Universities School of Medicine (SJTUSM), Shanghai, 200025, China; Shanghai Research Center for Model Organisms, Shanghai, 201203, China.
authors.forename: Xiaofang
authors.initials: X
authors.lastname: Cui
authors.affiliation: State Key Laboratory of Medical Genomics, Research Center for Experimental Medicine, Shanghai Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, 200025, China; Shanghai Research Center for Model Organisms, Shanghai, 201203, China.
authors.forename: Suying
authors.initials: S
authors.lastname: Dang
authors.affiliation: Department of Gastroenterology, Shanghai First People's Hospital Affiliated to SJTUSM, Shanghai, 200080, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Medical Genomics, Research Center for Experimental Medicine, Shanghai Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, 200025, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Medical Genomics, Research Center for Experimental Medicine, Shanghai Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, 200025, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Zhou
authors.affiliation: State Key Laboratory of Medical Genomics, Research Center for Experimental Medicine, Shanghai Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, 200025, China; Shanghai Research Center for Model Organisms, Shanghai, 201203, China.
authors.forename: Chunling
authors.initials: C
authors.lastname: Shen
authors.affiliation: Shanghai Research Center for Model Organisms, Shanghai, 201203, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Kuang
authors.affiliation: Shanghai Research Center for Model Organisms, Shanghai, 201203, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Fei
authors.affiliation: Department of Gastroenterology, Shanghai First People's Hospital Affiliated to SJTUSM, Shanghai, 200080, China.
authors.forename: Lungen
authors.initials: L
authors.lastname: Lu
authors.affiliation: State Key Laboratory of Medical Genomics, Research Center for Experimental Medicine, Shanghai Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, 200025, China; Model Organism Division, E-Institutes of Shanghai Jiao Tong Universities School of Medicine (SJTUSM), Shanghai, 200025, China; Shanghai Research Center for Model Organisms, Shanghai, 201203, China. Electronic address: zhugangw@shsmu.edu.cn.
authors.forename: Zhugang
authors.initials: Z
authors.lastname: Wang
mesh_terms: D000429:Alcohol Oxidoreductases / Q000172:deficiency* / Q000235:genetics; D000818:Animals; D015153:Blotting, Western; D002251:Carbon Tetrachloride / Q000633:toxicity*; D056486:Chemical and Drug Induced Liver Injury / Q000201:enzymology* / Q000378:metabolism / Q000473:pathology; D003094:Collagen / Q000096:biosynthesis; D005260:Female; D055166:Hepatic Stellate Cells / Q000201:enzymology / Q000473:pathology; D007150:Immunohistochemistry; D008103:Liver Cirrhosis / Q000201:enzymology* / Q000378:metabolism / Q000473:pathology; D008297:Male; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D060888:Real-Time Polymerase Chain Reaction; D019715:Tissue Inhibitor of Metalloproteinase-1 / Q000235:genetics; D053773:Transforming Growth Factor beta1 / Q000235:genetics
chemical_list: C560825:Timp1 protein, mouse; D019715:Tissue Inhibitor of Metalloproteinase-1; D053773:Transforming Growth Factor beta1; D003094:Collagen; D002251:Carbon Tetrachloride; D000429:Alcohol Oxidoreductases; C000614143:retinol dehydrogenase 13, mouse
keywords: Carbon tetrachloride; Hepatic stellate cells; Knockout; Liver fibrosis; Retinol dehydrogenase 13