title: Effect of exercise intensity on postprandial lipemia, markers of oxidative stress, and endothelial function after a high-fat meal.
abstract: The aim of this study was to compare the effects of 2 different exercise intensities on postprandial lipemia, oxidative stress markers, and endothelial function after a high-fat meal (HFM). Eleven young men completed 2-day trials in 3 conditions: rest, moderate-intensity exercise (MI-Exercise) and heavy-intensity exercise (HI-Exercise). Subjects performed an exercise bout or no exercise (Rest) on the evening of day 1. On the morning of day 2, an HFM was provided. Blood was sampled at fasting (0 h) and every hour from 1 to 5 h during the postprandial period for triacylglycerol (TAG), thiobarbituric acid reactive substance (TBARS), and nitrite/nitrate (NOx) concentrations. Flow-mediated dilatation (FMD) was also analyzed. TAG concentrations were reduced in exercise conditions compared with Rest during the postprandial period (P < 0.004). TAG incremental area under the curve (iAUC) was smaller after HI-Exercise compared with Rest (P = 0.012). TBARS concentrations were reduced in MI-Exercise compared with Rest (P < 0.041). FMD was higher in exercise conditions than Rest at 0 h (P < 0.02) and NOx concentrations were enhanced in MI-Exercise compared with Rest at 0 h (P < 0.01). These results suggest that acute exercise can reduce lipemia after an HFM. However, HI-Exercise showed to be more effective in reducing iAUC TAG, which might suggest higher protection against postprandial TAG enhancement. Conversely, MI-Exercise can be beneficial to attenuate the susceptibility of oxidative damage induced by an HFM and to increase endothelial function in the fasted state compared with Rest.
authors.affiliation: a Program of Human Movement Sciences, Faculty of Physical Education, Physiotherapy and Dance (ESEFID), Federal University of Rio Grande do Sul (UFRGS), 750 Felizardo Street, Porto Alegre, Rio Grande do Sul 90690-200, Brazil.|b Faculty of Kinesiology, University of Calgary, 2500 University Drive NW, Calgary, AB T2N 1N4, Canada.
authors.forename: Renata
authors.initials: R
authors.lastname: Lopes Krüger
authors.affiliation: a Program of Human Movement Sciences, Faculty of Physical Education, Physiotherapy and Dance (ESEFID), Federal University of Rio Grande do Sul (UFRGS), 750 Felizardo Street, Porto Alegre, Rio Grande do Sul 90690-200, Brazil.|c Physical Education School, Universidade Regional Integrada do Alto Uruguai e das Missões, 3149 José Bonifácio Street, São Luiz Gonzaga, Rio Grande do Sul 97800-000, Brazil.
authors.forename: Bruno
authors.initials: B
authors.lastname: Costa Teixeira
authors.affiliation: a Program of Human Movement Sciences, Faculty of Physical Education, Physiotherapy and Dance (ESEFID), Federal University of Rio Grande do Sul (UFRGS), 750 Felizardo Street, Porto Alegre, Rio Grande do Sul 90690-200, Brazil.
authors.forename: Juliano
authors.initials: J
authors.lastname: Boufleur Farinha
authors.affiliation: a Program of Human Movement Sciences, Faculty of Physical Education, Physiotherapy and Dance (ESEFID), Federal University of Rio Grande do Sul (UFRGS), 750 Felizardo Street, Porto Alegre, Rio Grande do Sul 90690-200, Brazil.
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Cauduro Oliveira Macedo
authors.affiliation: a Program of Human Movement Sciences, Faculty of Physical Education, Physiotherapy and Dance (ESEFID), Federal University of Rio Grande do Sul (UFRGS), 750 Felizardo Street, Porto Alegre, Rio Grande do Sul 90690-200, Brazil.
authors.forename: Francesco
authors.initials: F
authors.lastname: Pinto Boeno
authors.affiliation: a Program of Human Movement Sciences, Faculty of Physical Education, Physiotherapy and Dance (ESEFID), Federal University of Rio Grande do Sul (UFRGS), 750 Felizardo Street, Porto Alegre, Rio Grande do Sul 90690-200, Brazil.
authors.forename: Anderson
authors.initials: A
authors.lastname: Rech
authors.affiliation: a Program of Human Movement Sciences, Faculty of Physical Education, Physiotherapy and Dance (ESEFID), Federal University of Rio Grande do Sul (UFRGS), 750 Felizardo Street, Porto Alegre, Rio Grande do Sul 90690-200, Brazil.
authors.forename: Pedro
authors.initials: P
authors.lastname: Lopez
authors.affiliation: a Program of Human Movement Sciences, Faculty of Physical Education, Physiotherapy and Dance (ESEFID), Federal University of Rio Grande do Sul (UFRGS), 750 Felizardo Street, Porto Alegre, Rio Grande do Sul 90690-200, Brazil.
authors.forename: Ronei
authors.initials: R
authors.lastname: Silveira Pinto
authors.affiliation: a Program of Human Movement Sciences, Faculty of Physical Education, Physiotherapy and Dance (ESEFID), Federal University of Rio Grande do Sul (UFRGS), 750 Felizardo Street, Porto Alegre, Rio Grande do Sul 90690-200, Brazil.
authors.forename: Alvaro
authors.initials: A
authors.lastname: Reischak-Oliveira
mesh_terms: D015415:Biomarkers / Q000097:blood; D001938:Brazil / Q000453:epidemiology; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000517:prevention & control; D059305:Diet, High-Fat / Q000009:adverse effects*; D004730:Endothelium, Vascular / Q000378:metabolism / Q000502:physiology* / Q000503:physiopathology; D015444:Exercise; D005080:Exercise Test; D006801:Humans; D006949:Hyperlipidemias / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control*; D015227:Lipid Peroxidation; D008297:Male; D009566:Nitrates / Q000097:blood; D009573:Nitrites / Q000097:blood; D018384:Oxidative Stress; D005082:Physical Exertion; D010809:Physical Fitness; D019518:Postprandial Period; D012306:Risk; D012420:Running; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis; D014280:Triglycerides / Q000097:blood; D014664:Vasodilation
chemical_list: D015415:Biomarkers; D009566:Nitrates; D009573:Nitrites; D017392:Thiobarbituric Acid Reactive Substances; D014280:Triglycerides
keywords: dilatation dépendante du flux sanguin; dommage oxydatif; flow-mediated dilatation; lipid peroxidation; nitrites/nitrates; oxidative damage; peroxydation lipidique; postprandial responses; réponses postprandiales