title: Fast versus slow weight loss: development process and rationale behind the dietary interventions for the TEMPO Diet Trial.
abstract: Finding effective solutions to curb the obesity epidemic is a great global public health challenge. The need for long-term follow-up necessitates weight loss trials conducted in real-world settings, outside the confines of tightly controlled laboratory or clinic conditions. Given the complexity of eating behaviour and the food supply, this makes the process of designing a practical dietary intervention that stands up to scientific rigor difficult. Detailed information about the dietary intervention itself, as well as theprocessof developing the final intervention and its underlying rationale, is rarely reported in scientific weight management publications but is valuable and essential for translating research into practice. Thus, this paper describes the designprocessand underlying rationale behind the dietary interventions in an exemplar weight loss trial - the TEMPO Diet Trial (Type of Energy Manipulation for Promoting optimal metabolic health and body composition in Obesity). This trial assesses the long-term effects of fast versus slow weight loss on adiposity, fat free mass, muscle strength and bone density in women with obesity (body mass index 30-40 kg m-2) that are 45-65 years of age, postmenopausal and sedentary.
  
  
  
  This paper is intended as a resource for researchers and/or clinicians to illustrate how theoretical values based on a hypothesis can be translated into a dietary weight loss intervention to be used in free-living women of varying sizes.
authors.affiliation: Boden Institute of Obesity, Nutrition, Exercise & Eating Disorders, Sydney Medical School, Charles Perkins Centre University of Sydney Sydney NSW Australia.
authors.forename: A A
authors.initials: AA
authors.lastname: Gibson
authors.affiliation: Boden Institute of Obesity, Nutrition, Exercise & Eating Disorders, Sydney Medical School, Charles Perkins Centre University of Sydney Sydney NSW Australia.
authors.forename: R V
authors.initials: RV
authors.lastname: Seimon
authors.affiliation: Boden Institute of Obesity, Nutrition, Exercise & Eating Disorders, Sydney Medical School, Charles Perkins Centre University of Sydney Sydney NSW Australia.
authors.forename: J
authors.initials: J
authors.lastname: Franklin
authors.affiliation: Boden Institute of Obesity, Nutrition, Exercise & Eating Disorders, Sydney Medical School, Charles Perkins Centre University of Sydney  Sydney NSW Australia; Metabolism & Obesity Services Royal Prince Alfred Hospital Camperdown NSW Australia.
authors.forename: T P
authors.initials: TP
authors.lastname: Markovic
authors.affiliation: Bond Institute of Health and Sport, Faculty of Health Sciences and Medicine Bond University Gold Coast Australia.
authors.forename: N M
authors.initials: NM
authors.lastname: Byrne
authors.affiliation: Metabolism & Obesity Services Royal Prince Alfred Hospital Camperdown NSW Australia.
authors.forename: E
authors.initials: E
authors.lastname: Manson
authors.affiliation: Boden Institute of Obesity, Nutrition, Exercise & Eating Disorders, Sydney Medical School, Charles Perkins Centre University of Sydney  Sydney NSW Australia; Metabolism & Obesity Services Royal Prince Alfred Hospital Camperdown NSW Australia.
authors.forename: I D
authors.initials: ID
authors.lastname: Caterson
authors.affiliation: Boden Institute of Obesity, Nutrition, Exercise & Eating Disorders, Sydney Medical School, Charles Perkins Centre University of Sydney Sydney NSW Australia.
authors.forename: A
authors.initials: A
authors.lastname: Sainsbury
keywords: Clinical protocol; dietary protein; diet‐reducing; energy intake