title: Extracorporeal Clearance of Levetiracetam During Continuous Venovenous Hemofiltration in a Critically Ill Patient and New Dosing Recommendation.
authors.affiliation: Department of Intensive Care, VieCuri Medical Center, Venlo, The Netherlands.|Department of Pharmacology and Toxicology, Maastricht University, Maastricht, The Netherlands.
authors.forename: Jos L M L
authors.initials: JL
authors.lastname: le Noble
authors.affiliation: Department of Intensive Care, VieCuri Medical Center, Venlo, The Netherlands.
authors.forename: Norbert A
authors.initials: NA
authors.lastname: Foudraine
authors.affiliation: Department of Neurology, VieCuri Medical Center, Venlo, The Netherlands.
authors.forename: Francois H M
authors.initials: FH
authors.lastname: Kornips
authors.affiliation: Department of Intensive Care, VieCuri Medical Center, Venlo, The Netherlands.
authors.forename: Davy G H A
authors.initials: DG
authors.lastname: van Dam
authors.affiliation: CAPHRI School of Public Health and Primary Care Maastricht University, Maastricht, The Netherlands.|Department of Clinical Pharmacy and Toxicology, Maastricht University Medical Center, Maastricht, The Netherlands.
authors.forename: Cees
authors.initials: C
authors.lastname: Neef
authors.affiliation: Department of Clinical Pharmacy and Toxicology, Maastricht University Medical Center, Maastricht, The Netherlands.|Department of Hospital Pharmacy, VieCuri Medical Center, Venlo, The Netherlands.
authors.forename: Paddy K C
authors.initials: PK
authors.lastname: Janssen
mesh_terms: D000368:Aged; D000927:Anticonvulsants / Q000008:administration & dosage / Q000378:metabolism*; D016638:Critical Illness / Q000628:therapy*; D004305:Dose-Response Relationship, Drug; D005112:Extracorporeal Circulation / Q000379:methods; D006440:Hemofiltration / Q000379:methods* / Q000639:trends; D006801:Humans; D000077287:Levetiracetam; D008297:Male; D008657:Metabolic Clearance Rate / Q000187:drug effects / Q000502:physiology*; D010889:Piracetam / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000378:metabolism
chemical_list: D000927:Anticonvulsants; D000077287:Levetiracetam; D010889:Piracetam
keywords: antiepileptic drugs; continuous venovenous hemofiltration; epilepsy; levetiracetam