title: A rare cause of acute coronary syndrome: Kounis syndrome.
abstract: Kounis syndrome is an acute coronary syndrome in the context of a hypersensitivity reaction. The main pathophysiological mechanism appears to be coronary vasospasm. We report the case of a patient with a history of allergy to quinolones, who was given ciprofloxacin before an elective surgical procedure and during drug administration developed symptoms and electrocardiographic changes suggestive of ST-segment elevation acute coronary syndrome. The drug was suspended and coronary angiography excluded epicardial coronary disease. Two hours after withdrawal of the drug the symptoms and ST elevation had resolved completely.
authors.affiliation: Serviço de Cardiologia, Centro Hospitalar Vila Nova de Gaia/Espinho, Vila Nova de Gaia, Portugal. Electronic address: joaotgalmeida@gmail.com.
authors.forename: João
authors.initials: J
authors.lastname: Almeida
authors.affiliation: Serviço de Cardiologia, Hospital Divino Espírito Santo, Ponta Delgada, Portugal.
authors.forename: Sara
authors.initials: S
authors.lastname: Ferreira
authors.affiliation: Serviço de Medicina Interna, Centro Hospitalar Vila Nova de Gaia/Espinho, Vila Nova de Gaia, Portugal.
authors.forename: Joana
authors.initials: J
authors.lastname: Malheiro
authors.affiliation: Serviço de Cardiologia, Centro Hospitalar Vila Nova de Gaia/Espinho, Vila Nova de Gaia, Portugal.
authors.forename: Paulo
authors.initials: P
authors.lastname: Fonseca
authors.affiliation: Serviço de Cardiologia, Centro Hospitalar Vila Nova de Gaia/Espinho, Vila Nova de Gaia, Portugal.
authors.forename: Daniel
authors.initials: D
authors.lastname: Caeiro
authors.affiliation: Serviço de Cardiologia, Centro Hospitalar Vila Nova de Gaia/Espinho, Vila Nova de Gaia, Portugal.
authors.forename: Adelaide
authors.initials: A
authors.lastname: Dias
authors.affiliation: Serviço de Cardiologia, Centro Hospitalar Vila Nova de Gaia/Espinho, Vila Nova de Gaia, Portugal.
authors.forename: José
authors.initials: J
authors.lastname: Ribeiro
authors.affiliation: Serviço de Cardiologia, Centro Hospitalar Vila Nova de Gaia/Espinho, Vila Nova de Gaia, Portugal.
authors.forename: Vasco
authors.initials: V
authors.lastname: Gama
mesh_terms: D054058:Acute Coronary Syndrome / Q000209:etiology*; D000369:Aged, 80 and over; D017023:Coronary Angiography; D003329:Coronary Vasospasm / Q000150:complications; D004562:Electrocardiography; D006801:Humans; D000074962:Kounis Syndrome / Q000150:complications*; D008297:Male
keywords: Acute coronary syndrome; Alergia; Allergy; Coronary vasospasm; Kounis syndrome; Síndrome coronária aguda; Síndrome de Kounis; Vasospasmo coronário