title: Improved Antiviral Activity of a Polyamide Against High-Risk Human PapillomavirusViaN-Terminal Guanidinium Substitution.
abstract: We report the synthesis of two novel pyrrole-imidazole polyamides with N-terminal guanidinium or tetramethylguanidinium groups and evaluate their antiviral activity against three cancer-causing human papillomavirus strains. Introduction of guanidinium improves antiviral activity when compared to an unsubstituted analog, especially in IC90values. These substitutions change DNA-binding preferences, while binding affinity remains unchanged.
authors.affiliation: Department of Chemistry & Biochemistry, University of Missouri-St. Louis, St. Louis, MO 63121, USA.
authors.forename: C H
authors.initials: CH
authors.lastname: Castaneda
authors.affiliation: Department of Chemistry & Biochemistry, University of Missouri-St. Louis, St. Louis, MO 63121, USA.
authors.forename: M J
authors.initials: MJ
authors.lastname: Scuderi
authors.affiliation: Department of Chemistry & Biochemistry, University of Missouri-St. Louis, St. Louis, MO 63121, USA.
authors.forename: T G
authors.initials: TG
authors.lastname: Edwards
authors.affiliation: Department of Chemistry & Biochemistry, University of Missouri-St. Louis, St. Louis, MO 63121, USA.
authors.forename: G D
authors.initials: GD
authors.lastname: Harris
authors.affiliation: Department of Chemistry & Biochemistry, University of Missouri-St. Louis, St. Louis, MO 63121, USA.
authors.forename: C M
authors.initials: CM
authors.lastname: Dupureur
authors.affiliation: Department of Chemistry & Biochemistry, University of Missouri-St. Louis, St. Louis, MO 63121, USA.
authors.forename: K J
authors.initials: KJ
authors.lastname: Koeller
authors.affiliation: NanoVir, LLC, Kalamazoo, MI 49008 (USA).
authors.forename: C
authors.initials: C
authors.lastname: Fisher
authors.affiliation: Department of Chemistry & Biochemistry, University of Missouri-St. Louis, St. Louis, MO 63121, USA; NanoVir, LLC, Kalamazoo, MI 49008 (USA).
authors.forename: J K
authors.initials: JK
authors.lastname: Bashkin