title: Parenchymal density changes in acute pulmonary embolism: Can quantitative CT be a diagnostic tool? A preliminary study.
abstract: OBJECTIVE
  Determine the ability of quantitative CT (QCT) in defining parenchymal density changes in acute pulmonary embolism (PE).
  
  
  METHODS
  Mean lung density (MLD) and percentage distribution values (PDV) were calculated in 34 patients suspected of PE using software application based on computerized volumetric anatomical segmentation.
  
  
  RESULTS
  Total, left, and right MLD differed significantly between emboli positive(n=23) and negative(n=11) groups(p<0.006, p<0.009, p<0.014). PDVs differed between groups (p<0.05) except for LUZ and RLZ. When PE was present in lobe &/segment branches, PDVs were significantly lower except RUZ.
  
  
  CONCLUSIONS
  QCT is a promising application for defining parenchymal density changes in PE revealing potential functional impact of emboli. This preliminary study suggests QCT could provide added value to CTPA in peripheral PE.
authors.affiliation: Marmara University Training and Research Hospital, Department of Radiology, Istanbul, Turkey. Electronic address: edda_ikram@hotmail.com.
authors.forename: Ikram Eda
authors.initials: IE
authors.lastname: Duman
authors.affiliation: Marmara University Training and Research Hospital, Department of Radiology, Istanbul, Turkey. Electronic address: canancimsit@gmail.com.
authors.forename: Canan
authors.initials: C
authors.lastname: Cimsit
authors.affiliation: Marmara University Training and Research Hospital, Department of Pulmonary Medicine and IntensiveCare, Istanbul, Turkey. Electronic address: drsehnazolgun@yahoo.com.
authors.forename: Sehnaz Olgun
authors.initials: SO
authors.lastname: Yildizeli
authors.affiliation: Marmara University Training and Research Hospital, Department of Radiology, Istanbul, Turkey. Electronic address: cagataycimsit@gmail.com.
authors.forename: Nuri Cagatay
authors.initials: NC
authors.lastname: Cimsit
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011651:Pulmonary Artery / Q000000981:diagnostic imaging; D011655:Pulmonary Embolism / Q000000981:diagnostic imaging*; D015203:Reproducibility of Results; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed
keywords: CTPA; Density mapping; Pulmonary embolism; Quantitative CT