title: Impact of Non-Invasive Ventilation on Sympathetic Nerve Activity in Chronic Obstructive Pulmonary Disease.
abstract: Chronic obstructive pulmonary disease (COPD) is associated with elevated sympathetic nerve activity, which is probably linked to an increased cardiovascular risk, and may contribute to muscle dysfunction by heightened muscle vasoconstrictor drive. We hypothesized that resistive unloading of respiratory muscles by intermittent non-invasive ventilation (NIV) reduces sympathetic tone at rest and during subsequent handgrip exercise in patients with COPD.
  
  
  
  Muscle sympathetic nerve activity (MSNA) in the peroneal nerve, heart rate, blood pressure, CO2, and SpO2were continuously recorded in 5 COPD patients with intermittent NIV and 11 control COPD patients without NIV. Static and dynamic handgrip exercises were performed before and after NIV.
  
  
  
  At baseline, heart rate-adjusted MSNA (bursts/100 heart beats) did not differ between groups. NIV did not significantly affect MSNA levels at rest. However, during handgrip exercises directly following NIV, MSNA was lower than before, which was significant for dynamic handgrip (67.00 ± 3.70 vs. 62.13 ± 4.50 bursts/100 heart beats; p = 0.035 in paired t test). In contrast, MSNA (non-significantly) increased in the control group during repeated dynamic or static handgrip. During dynamic handgrip, tCO2was lower after NIV than before (change by -5.04 ± 0.68 mmHg vs. -0.53 ± 0.64 in the control group; p = 0.021), while systolic and diastolic blood pressure did not change significantly.
  
  
  
  NIV reduces sympathetic activation during subsequent dynamic handgrip exercise and thereby may elicit positive effects on the cardiovascular system as well as on muscle function in patients with COPD.
authors.affiliation: Clinic for Cardiology and Pneumology, University Medical Center Göttingen, 37099, Göttingen, Germany.
authors.forename: Helge
authors.initials: H
authors.lastname: Haarmann
authors.affiliation: Clinic for Cardiology and Pneumology, University Medical Center Göttingen, 37099, Göttingen, Germany.
authors.forename: Jan
authors.initials: J
authors.lastname: Folle
authors.affiliation: Mannheim Biomedical Engineering Laboratories, Medical Faculty at Heidelberg University, Mannheim, Germany.
authors.forename: Xuan Phuc
authors.initials: XP
authors.lastname: Nguyen
authors.affiliation: Clinic for Anaesthesiology, University Medical Center Göttingen, Göttingen, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Herrmann
authors.affiliation: Institute of Clinical Pharmacology, Hannover Medical School, Hannover, Germany.
authors.forename: Karsten
authors.initials: K
authors.lastname: Heusser
authors.affiliation: Clinic for Cardiology and Pneumology, University Medical Center Göttingen, 37099, Göttingen, Germany.
authors.forename: Gerd
authors.initials: G
authors.lastname: Hasenfuß
authors.affiliation: Clinic for Cardiology and Pneumology, University Medical Center Göttingen, 37099, Göttingen, Germany.|Lung Clinic Immenhausen, Immenhausen, Krs. Kassel, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Andreas
authors.affiliation: Clinic for Cardiology and Pneumology, University Medical Center Göttingen, 37099, Göttingen, Germany. raupach@med.uni-goettingen.de.
authors.forename: Tobias
authors.initials: T
authors.lastname: Raupach
mesh_terms: D000368:Aged; D001794:Blood Pressure; D002245:Carbon Dioxide / Q000097:blood; D015444:Exercise / Q000502:physiology; D005080:Exercise Test; D005260:Female; D018737:Hand Strength / Q000502:physiology; D006339:Heart Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000503:physiopathology; D063087:Noninvasive Ventilation; D010100:Oxygen / Q000097:blood; D010543:Peroneal Nerve / Q000503:physiopathology*; D029424:Pulmonary Disease, Chronic Obstructive / Q000503:physiopathology / Q000628:therapy*; D012146:Rest / Q000502:physiology; D013564:Sympathetic Nervous System / Q000503:physiopathology*
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen
keywords: Autonomic nervous system; Chronic obstructive pulmonary disease; Exercise; Non-invasive ventilation; Sympathetic nerve activity