title: Automated macular choroidal thickness measurement by swept-source optical coherence tomography in pseudoxanthoma elasticum.
abstract: BACKGROUND
  Pseudoxanthoma elasticum (PXE) typically involves elastic fibers in blood vessels and Bruch membrane. Our purpose was to analyze retinal and choroidal macular thickness in patients with angioid streaks due PXE compared with a control group.
  
  
  METHODS
  Best-corrected visual acuity (BCVA), axial length (AL), and macular swept-source optical coherence tomography were obtained. Automated segmentations of the retina and the choroid were used to obtain the corresponding thickness values. An age, gender and AL matched control group was used to compare the thickness values.
  
  
  RESULTS
  Twelve eyes of 6 patients were included. The mean BCVA was 0.68 ± 0.29 versus 1.0 in controls (p < 0.001). The mean macular retinal thickness was thinner in eyes with PXE (p = 0.038). Only patients with choroidal neovascularization (NV) showed statistically significant differences in the mean macular choroidal thickness (p = 0.008).
  
  
  CONCLUSIONS
  The present study shows that choroidal thickness may be thinner in eyes with NV due to angioid streaks in PXE compared with healthy eyes analyzed by an automated segmentation of the choroid. Further studies are warranted in order to assess the importance of this choroidal changes in the pathogenesis of retinal disturbances related to PXE and its influence in long-term follow-up.
authors.affiliation: Unit of Macula, Department of Ophthalmology, University and Polytechnic Hospital La Fe, Bulevar Sur s/n, 46026 Valencia, Spain ; RETICS RD12/0034 Enfermedades oculares: «Prevención, detección precoz y tratamiento de la patología ocular prevalente degenerativa y crónica», Instituto de Salud Carlos III, Madrid, Spain.
authors.forename: Rosa
authors.initials: R
authors.lastname: Dolz-Marco
authors.affiliation: Unit of Macula, Department of Ophthalmology, University and Polytechnic Hospital La Fe, Bulevar Sur s/n, 46026 Valencia, Spain ; RETICS RD12/0034 Enfermedades oculares: «Prevención, detección precoz y tratamiento de la patología ocular prevalente degenerativa y crónica», Instituto de Salud Carlos III, Madrid, Spain.
authors.forename: María
authors.initials: M
authors.lastname: Andreu-Fenoll
authors.affiliation: Unit of Macula, Department of Ophthalmology, University and Polytechnic Hospital La Fe, Bulevar Sur s/n, 46026 Valencia, Spain.
authors.forename: Pablo
authors.initials: P
authors.lastname: Hernández-Martínez
authors.affiliation: RETICS RD12/0034 Enfermedades oculares: «Prevención, detección precoz y tratamiento de la patología ocular prevalente degenerativa y crónica», Instituto de Salud Carlos III, Madrid, Spain ; Ophthalmology Research Unit "Santiago Grisolía", University Hospital Doctor Peset, Valencia, Spain ; Department of Surgery, Faculty of Medicine, University of Valencia, Valencia, Spain.
authors.forename: M Dolores
authors.initials: MD
authors.lastname: Pinazo-Durán
authors.affiliation: Unit of Macula, Department of Ophthalmology, University and Polytechnic Hospital La Fe, Bulevar Sur s/n, 46026 Valencia, Spain ; RETICS RD12/0034 Enfermedades oculares: «Prevención, detección precoz y tratamiento de la patología ocular prevalente degenerativa y crónica», Instituto de Salud Carlos III, Madrid, Spain.
authors.forename: Roberto
authors.initials: R
authors.lastname: Gallego-Pinazo
keywords: Automated segmentation; Choroid; Neovascularization; PXE