title: A Microwave-Promoted/Assisted Method for Rapid Preparation of Biaryl Seven-membered Lactones.
abstract: BACKGROUND
  Biaryl seven-membered lactones (BSLs), the target compounds are a class of bioactive compounds with anti-arrhythmic activity, which also serve as a starting material or structural units for chemical synthesis.
  
  
  OBJECTIVE
  To report a simple and efficient procedure for the synthesis of biaryl seven-membered lactones.
  
  
  METHODS
  Under microwave, the umpolung reaction was promoted by N-heterocyclic carbenes under oxygen, with anhydrous potassium carbonate as base and with 1,4,7,10,13,16-Hexanoxacyclooctadecane (18-crown-6) as a phase-transfer catalyst.
  
  
  RESULTS
  The practical protocol was found to be compatible with different structurally diverse substrates and with moderate to excellent yields.
  
  
  CONCLUSIONS
  This synthesis method has the advantage of high efficacy and novelty, short reaction time, operation simplicity, mild condition and high yields, providing a useful and atom-economic approach to the synthesis of BSLs.
authors.affiliation: College of Chemistry & Chemical Engineering, Shaoxing University, Shaoxing 312000, China.
authors.forename: Chunqi
authors.initials: C
authors.lastname: Hu
authors.affiliation: Department of Pharmacy, Hangzhou Medical College, 481 Binwen Road, Hangzhou 310053, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Pharmacy, Hangzhou Medical College, 481 Binwen Road, Hangzhou 310053, China; Wenzhou Medical University, Wenzhou 325035, China.
authors.forename: Wenting
authors.initials: W
authors.lastname: Du
mesh_terms: D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry; D008872:Microwaves; D015394:Molecular Structure
chemical_list: D007783:Lactones
keywords: BSLs; N-heterocyclic carbine; carbene salt; lactones; microwave; umpolung reaction