title: Polycythemia and Thrombocytosis.
abstract: Myeloproliferative neoplasms (MPNs) are diseases of excess cell proliferation from bone marrow precursors. Two classic MPNs, polycythemia vera (PV) and essential thrombocytosis (ET), are conditions of excess proliferation of red blood cells and platelets, respectively. Although PV and ET involve different cells in the myeloid lineage, their clinical presentations have shared features, consistent with overlapping mutations in growth factor signaling. The management of both diseases involves minimizing the risk of thrombotic and hemorrhagic complications. Both PV and ET can progress to myelofibrosis or acute myeloid leukemia, portending a poor prognosis. MPNs can also present as primary myelofibrosis.
authors.affiliation: Division of Hematology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA; Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA. Electronic address: aparnes@partners.org.
authors.forename: Aric
authors.initials: A
authors.lastname: Parnes
authors.affiliation: Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA.
authors.forename: Arvind
authors.initials: A
authors.lastname: Ravi
mesh_terms: D003937:Diagnosis, Differential; D019468:Disease Management; D018450:Disease Progression; D006403:Hematologic Tests; D006801:Humans; D011086:Polycythemia / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy*; D011320:Primary Health Care; D011379:Prognosis; D013922:Thrombocytosis / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy*
keywords: Essential thrombocytosis; JAK2 mutation; Myelofibrosis; Myeloproliferative neoplasms; Polycythemia vera