title: Immune responses in perinatal brain injury.
abstract: The perinatal period has often been described as immune deficient. However, it has become clear that immune responses in the neonate following exposure to microbes or as a result of tissue injury may be substantial and play a role in perinatal brain injury. In this article we will review the immune cell composition under normal physiological conditions in the perinatal period, both in the human and rodent. We will summarize evidence of the inflammatory responses to stimuli and discuss how neonatal immune activation, both in the central nervous system and in the periphery, may contribute to perinatal hypoxic-ischemic brain injury.
authors.affiliation: Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Box 432, 405 30 Gothenburg, Sweden.
authors.forename: Jacqueline C Y
authors.initials: JCY
authors.lastname: Lai
authors.affiliation: Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Box 432, 405 30 Gothenburg, Sweden.
authors.forename: Eridan
authors.initials: E
authors.lastname: Rocha-Ferreira
authors.affiliation: Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Box 432, 405 30 Gothenburg, Sweden.
authors.forename: C Joakim
authors.initials: CJ
authors.lastname: Ek
authors.affiliation: Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Box 432, 405 30 Gothenburg, Sweden.
authors.forename: Xiaoyang
authors.initials: X
authors.lastname: Wang
authors.affiliation: Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Box 432, 405 30 Gothenburg, Sweden.
authors.forename: Henrik
authors.initials: H
authors.lastname: Hagberg
authors.affiliation: Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Box 432, 405 30 Gothenburg, Sweden. Electronic address: carina.mallard@neuro.gu.se.
authors.forename: Carina
authors.initials: C
authors.lastname: Mallard
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000276:immunology*; D001930:Brain Injuries / Q000276:immunology; D005260:Female; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000276:immunology*; D007112:Immunity, Maternally-Acquired / Q000276:immunology*; D007231:Infant, Newborn; D011247:Pregnancy; D012377:Rodentia
keywords: Brain injury; Hypoxia-ischemia; Inflammation; Neonatal; Peripheral immune