title: Analysis of adverse events following immunization in Minas Gerais, Brazil, 2011: a cross-sectional study.
abstract: to analyze the main adverse events occurring following immunization in Minas Gerais State, Brazil, in 2011.
  
  
  
  this is a cross-sectional study using secondary data from the Brazilian Information System on Adverse Events Following Immunization.
  
  
  
  1,449 adverse events were found; more than half occurred in children under one year of age (56.1%; OR=1.39; 95%CI: 1.08;1.78); the highest rates per 100,000 doses administered were found in the Southern Triangle (36.3), Northwest (25.7) and Southern (22.7) areas of the state; tetravalent vaccine had the highest reactogenicity (46.1%) and hypotonic-hyporesponsive episode was the most frequent event (15.9%); events were significantly associated with inactivated vaccines (OR=4.08; 95%CI: 3.51;4.75); most of the reported events were closed as 'undefined' (58.9%).
  
  
  
  events were found in all regions of Minas Gerais state and were most frequent following administration of inactivated vaccines and among children under one year of age.
authors.affiliation: Governo do Estado de Minas Gerais, Secretaria de Estado de Saúde, Divinópolis-MG, Brasil.
authors.forename: Suelem Santos
authors.initials: SS
authors.lastname: Silva
authors.affiliation: Universidade Federal de São João Del Rei, Faculdade de Enfermagem, Divinópolis-MG, Brasil.
authors.forename: Valéria Conceição de
authors.initials: VC
authors.lastname: Oliveira
authors.affiliation: Governo do Estado de Minas Gerais, Secretaria de Estado de Saúde, Divinópolis-MG, Brasil.|Universidade Federal de São João Del Rei, Faculdade de Enfermagem, Divinópolis-MG, Brasil.
authors.forename: Helen Cristiny Teodoro Couto
authors.initials: HC
authors.lastname: Ribeiro
authors.affiliation: Universidade Federal de São João Del Rei, Faculdade de Enfermagem, Divinópolis-MG, Brasil.
authors.forename: Tamara Gabriela Silva
authors.initials: TG
authors.lastname: Alves
authors.affiliation: Universidade Federal de São João Del Rei, Faculdade de Enfermagem, Divinópolis-MG, Brasil.
authors.forename: Ricardo Bezerra
authors.initials: RB
authors.lastname: Cavalcante
authors.affiliation: Governo do Estado de Minas Gerais, Secretaria de Estado de Saúde, Divinópolis-MG, Brasil.|Universidade Federal de São João Del Rei, Faculdade de Enfermagem, Divinópolis-MG, Brasil.
authors.forename: Eliete Albano de Azevedo
authors.initials: EA
authors.lastname: Guimarães
mesh_terms: D000293:Adolescent; D000328:Adult; D016907:Adverse Drug Reaction Reporting Systems; D017677:Age Distribution; D001938:Brazil; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D049308:Dioxygenases; D005260:Female; D056466:Histone Demethylases; D006801:Humans; D007114:Immunization; D017589:Immunization Programs; D007117:Immunization, Secondary; D007223:Infant; D008297:Male; D008875:Middle Aged; D009687:Nuclear Proteins; D017678:Sex Distribution; D014611:Vaccination / Q000009:adverse effects*; D014612:Vaccines / Q000009:adverse effects*; D055815:Young Adult
chemical_list: D009687:Nuclear Proteins; D014612:Vaccines; D049308:Dioxygenases; D056466:Histone Demethylases; C466777:RIOX2 protein, human