title: Regulation of gene expression and mitochondrial dynamics by SMAD.
abstract: Mothers against decapentaplegic homolog (SMAD) proteins exert a wide spectrum of transcriptional effects in different cell types and tissues in response to transforming growth factor-β (TGF-β). A recent study demonstrates what is thought to be the first distinct cytoplasmic function for SMAD2 in modulating mitochondrial dynamics and hence reveals new pathophysiological implications for TGF-β signaling.
authors.affiliation: Division of Pharmacology, College of Pharmacy , Columbus, OH, USA.
authors.forename: Nirav
authors.initials: N
authors.lastname: Shah
authors.affiliation: Division of Pharmacology, College of Pharmacy, Columbus, OH, USA; Davis Heart and Lung Research Institute, Columbus, OH, USA; James Comprehensive Cancer Center, Columbus, OH, USA.
authors.forename: Nam Y
authors.initials: NY
authors.lastname: Lee
keywords: MFN2; RIN1; SMAD; mitochondria; transforming growth factor beta