title: The influence of mortality rate from membrane flux for end-stage renal disease: A meta-analysis.
abstract: To evaluate the influence of the high-flux hemodialysis (HFHD) and the low-flux hemodialysis (LFHD) on mortality rate for end-stage renal disease (ESRD). Four electronic databases including PubMed, EMBASE, the Cochrane Library, and ClinicalTrails were searched to identify relevant randomized clinical trials up to 31 August 2015. Seven studies enrolling a total of 4412 patients were included in this meta-analysis. For all-cause mortality comparing with LFHD, the result showed that there were significant difference (RR=0.75; 95% CI [0.60-0.94]; I2=84%; P<0.00001). For death due to infection comparing with LFHD, the result showed that there was no significant difference (RR=0.92; 95% CI [0.75-1.13]; I2=0%; P=0.86). For cardiovascular mortality, the overall meta-analysis result showed that there was a significant difference between the HFHD versus the LFHD (RR=0.75; 95% CI [0.60-0.94]; I2=55%; P=0.11). Publication bias was not detected by funnel plot. Based on these results, our study suggests that the HFHD has superior effectiveness over LFHD for long-term survival in ESRD.
authors.affiliation: Department of blood transfusion medicine and nephrology, Linzi District People's Hospital, Binzhou Medical University, No. 139, Huangong Road, Linzi District, Zibo City 255400, Shandong Province, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Zhao
authors.affiliation: Department of urinary surgery, Linzi District People's Hospital, Binzhou Medical University, No. 139, Huangong Road, Linzi District, Zibo City 255400, Shandong Province, China.
authors.forename: Zhipeng
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Linzi District People's Hospital, Binzhou Medical University, No. 139, Huangong Road, Linzi District, Zibo City 255400, Shandong Province, China; Medical intensive care unit, PKUCare Luzhong Hospital, No. 65, Taigong Road, Linzi District, Zibo City 255400, Shandong Province, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Liu
authors.affiliation: Department of biotherapy, Linzi District People's Hospital, Binzhou Medical University, No. 139, Huangong Road, Linzi District, Zibo City 255400, Shandong Province, China. Electronic address: shengwangemail@163.com.
authors.forename: Sheng
authors.initials: S
authors.lastname: Wang
mesh_terms: D002318:Cardiovascular Diseases / Q000401:mortality; D006801:Humans; D007676:Kidney Failure, Chronic / Q000401:mortality* / Q000628:therapy*; D009894:Opportunistic Infections / Q000401:mortality; D006435:Renal Dialysis / Q000379:methods*
keywords: All-cause mortality; Cardiovascular mortality; End-stage renal; Hemodialysis; Meta-analysis