title: In vitro and in vivo MRI visualization of nanocomposite biodegradable microcapsules with tunable contrast.
abstract: Microcapsules, made of biodegradable polymers, containing magnetite nanoparticles with tunable contrast in both the T1 and T2 MRI modes, were successfully prepared using a layer-by-layer approach. The MRI contrast of the microcapsules was shown to depend on the distance between magnetite nanoparticles in the polymeric layers, which is controlled by their concentration in the microcapsule shell. A fivefold increase in the average distance between the nanoparticles in the microcapsule shell led to a change in the intensity of the MR signal of 100% for both the T1 and T2 modes. Enzyme treatment of biodegradable shells resulted in a change of the microcapsules' MRI contrast. In vivo degradation of nanocomposite microcapsules concentrated in the liver after intravenous injection was demonstrated by MRI. This method can be used for the creation of a new generation of drug delivery systems, including drug depot, with combined navigation, visualization and remote activated release of bioactive substances in vivo.
authors.affiliation: Saratov State University, 83 Astrakhanskaya Str., Saratov, 410012, Russia. gorinda@mail.ru.
authors.forename: Sergey V
authors.initials: SV
authors.lastname: German
authors.affiliation: Saratov State University, 83 Astrakhanskaya Str., Saratov, 410012, Russia. gorinda@mail.ru.
authors.forename: Daniil N
authors.initials: DN
authors.lastname: Bratashov
authors.affiliation: Saratov State University, 83 Astrakhanskaya Str., Saratov, 410012, Russia. gorinda@mail.ru and Saratov State Medical University, 112 Bolshaya Kazachia Str., Saratov, 410012, Russia.
authors.forename: Nikita A
authors.initials: NA
authors.lastname: Navolokin
authors.affiliation: Saratov State University, 83 Astrakhanskaya Str., Saratov, 410012, Russia. gorinda@mail.ru.
authors.forename: Anastasia A
authors.initials: AA
authors.lastname: Kozlova
authors.affiliation: Saratov State University, 83 Astrakhanskaya Str., Saratov, 410012, Russia. gorinda@mail.ru.
authors.forename: Maria V
authors.initials: MV
authors.lastname: Lomova
authors.affiliation: Saratov State University, 83 Astrakhanskaya Str., Saratov, 410012, Russia. gorinda@mail.ru.
authors.forename: Marina V
authors.initials: MV
authors.lastname: Novoselova
authors.affiliation: Alexander Butlerov Institute of Chemistry, Kazan Federal University, 18 Kremlyovskaya Str, Kazan, 420008, Republic of Tatarstan, Russia.
authors.forename: Evgeniya A
authors.initials: EA
authors.lastname: Burilova
authors.affiliation: Saratov State University, 83 Astrakhanskaya Str., Saratov, 410012, Russia. gorinda@mail.ru and Saratov State Medical University, 112 Bolshaya Kazachia Str., Saratov, 410012, Russia.
authors.forename: Victor V
authors.initials: VV
authors.lastname: Zyev
authors.affiliation: Saratov State University, 83 Astrakhanskaya Str., Saratov, 410012, Russia. gorinda@mail.ru and Institute of Biochemistry and Physiology of Plants and Microorganisms, 13 Prospekt Entuziastov, Saratov 410049, Russia.
authors.forename: Boris N
authors.initials: BN
authors.lastname: Khlebtsov
authors.affiliation: Saratov State Medical University, 112 Bolshaya Kazachia Str., Saratov, 410012, Russia.
authors.forename: Alla B
authors.initials: AB
authors.lastname: Bucharskaya
authors.affiliation: Saratov State Medical University, 112 Bolshaya Kazachia Str., Saratov, 410012, Russia.
authors.forename: Georgy S
authors.initials: GS
authors.lastname: Terentyuk
authors.affiliation: Alexander Butlerov Institute of Chemistry, Kazan Federal University, 18 Kremlyovskaya Str, Kazan, 420008, Republic of Tatarstan, Russia.
authors.forename: Rustem R
authors.initials: RR
authors.lastname: Amirov
authors.affiliation: Saratov State Medical University, 112 Bolshaya Kazachia Str., Saratov, 410012, Russia.
authors.forename: Galina N
authors.initials: GN
authors.lastname: Maslyakova
authors.affiliation: Saratov State University, 83 Astrakhanskaya Str., Saratov, 410012, Russia. gorinda@mail.ru and Queen Mary, University of London, Mile End Road, London, E1 4NS, UK.
authors.forename: Gleb B
authors.initials: GB
authors.lastname: Sukhorukov
authors.affiliation: Saratov State University, 83 Astrakhanskaya Str., Saratov, 410012, Russia. gorinda@mail.ru.
authors.forename: Dmitry A
authors.initials: DA
authors.lastname: Gorin
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D002214:Capsules; D016503:Drug Delivery Systems; D008279:Magnetic Resonance Imaging; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D053761:Nanocomposites / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D002214:Capsules; D058185:Magnetite Nanoparticles