title: Exosomes in immunoregulation of chronic lung diseases.
abstract: Exosomes are nano-sized, membrane-bound vesicles released from cells that transport cargo including DNA, RNA, and proteins, between cells as a form of intercellular communication. In addition to their role in intercellular communication, exosomes are beginning to be appreciated as agents of immunoregulation that can modulate antigen presentation, immune activation, suppression, and surveillance. This article summarizes how these multifaceted functions of exosomes may promote development and/or progression of chronic inflammatory lung diseases including asthma, chronic obstructive pulmonary disease, and pulmonary fibrosis. The potential of exosomes as a novel therapeutic is also discussed.
authors.affiliation: Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
authors.forename: K P
authors.initials: KP
authors.lastname: Hough
authors.affiliation: Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
authors.forename: D
authors.initials: D
authors.lastname: Chanda
authors.affiliation: Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
authors.forename: S R
authors.initials: SR
authors.lastname: Duncan
authors.affiliation: Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
authors.forename: V J
authors.initials: VJ
authors.lastname: Thannickal
authors.affiliation: Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
authors.forename: J S
authors.initials: JS
authors.lastname: Deshane
mesh_terms: D000818:Animals; D001692:Biological Transport; D015415:Biomarkers; D002908:Chronic Disease; D055354:Exosomes / Q000378:metabolism*; D005786:Gene Expression Regulation; D006706:Homeostasis; D006801:Humans; D056747:Immunomodulation; D008171:Lung Diseases / Q000209:etiology* / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D012140:Respiratory Tract Diseases / Q000209:etiology / Q000378:metabolism / Q000473:pathology / Q000628:therapy; D015398:Signal Transduction; D000068936:Theranostic Nanomedicine
chemical_list: D015415:Biomarkers
keywords: chronic lung diseases; exosomes; extracellular vesicles; immunoregulation; inflammation