title: High Mobility Group Box-1: A Missing Link between Diabetes and Its Complications.
abstract: High mobility group box-1 (HMGB-1), a damage-associated molecular pattern, can be actively or passively released from various cells under different conditions and plays a pivotal role in the pathogenesis of inflammation and angiogenesis-dependent diseases. More and more evidence suggests that inflammation, in addition to its role in progression of diabetes, also promotes initiation and development of diabetic complications. In this review, we focus on the role of HMGB-1 in diabetes-related complications and the therapeutic strategies targeting HMGB-1 in diabetic complications.
authors.affiliation: Department of Cardiology, Drum Tower Hospital, Nanjing University Medical School, Nanjing 210008, China.
authors.forename: Han
authors.initials: H
authors.lastname: Wu
authors.affiliation: Department of Cardiology, Drum Tower Hospital, Nanjing University Medical School, Nanjing 210008, China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Department of Cardiology, Drum Tower Hospital, Nanjing University Medical School, Nanjing 210008, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Xie
authors.affiliation: Department of Cardiology, Drum Tower Hospital, Nanjing University Medical School, Nanjing 210008, China.
authors.forename: Li-Na
authors.initials: LN
authors.lastname: Kang
authors.affiliation: Department of Cardiology, Drum Tower Hospital, Nanjing University Medical School, Nanjing 210008, China.
authors.forename: Lian
authors.identifier: 0000-0003-1088-7103
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Cardiology, Drum Tower Hospital, Nanjing University Medical School, Nanjing 210008, China.
authors.forename: Biao
authors.identifier: 0000-0001-7259-298X
authors.initials: B
authors.lastname: Xu
mesh_terms: D000818:Animals; D017209:Apoptosis; D002318:Cardiovascular Diseases / Q000378:metabolism; D048909:Diabetes Complications / Q000378:metabolism*; D003928:Diabetic Nephropathies / Q000473:pathology; D018450:Disease Progression; D024243:HMGB1 Protein / Q000378:metabolism*; D006801:Humans; D007249:Inflammation; D007328:Insulin / Q000172:deficiency; D007333:Insulin Resistance; D007515:Islets of Langerhans / Q000166:cytology; D018384:Oxidative Stress; D015398:Signal Transduction
chemical_list: D024243:HMGB1 Protein; C585491:HMGB1 protein, human; D007328:Insulin