title: The heart of epilepsy: Current views and future concepts.
abstract: Cardiovascular (CV) comorbidities are common in people with epilepsy. Several mechanisms explain why these conditions tend to co-exist including causal associations, shared risk factors and those resulting from epilepsy or its treatment. Various arrhythmias occurring during and after seizures have been described. Ictal asystole is the most common cause. The converse phenomenon, arrhythmias causing seizures, appears extremely rare and has only been reported in children following cardioinihibitory syncope. Arrhythmias in epilepsy may not only result from seizure activity but also from a shared genetic susceptibility. Various cardiac and epilepsy genes could be implicated but firm evidence is still lacking. Several antiepileptic drugs (AEDs) triggering conduction abnormalities can also explain the co-existence of arrhythmias in epilepsy. Epidemiological studies have consistently shown that people with epilepsy have a higher prevalence of structural cardiac disease and a poorer CV risk profile than those without epilepsy. Shared CV risk factors, genetics and etiological factors can account for a significant part of the relationship between epilepsy and structural cardiac disease. Seizure activity may cause transient myocardial ischaemia and the Takotsubo syndrome. Additionally, certain AEDs may themselves negatively affect CV risk profile in epilepsy. Here we discuss the fascinating borderland of epilepsy and cardiovascular conditions. The review focuses on epidemiology, clinical presentations and possible mechanisms for shared pathophysiology. It concludes with a discussion of future developments and a call for validated screening instruments and guidelines aiding the early identification and treatment of CV comorbidity in epilepsy.
authors.affiliation: Stichting Epilepsie Instellingen Nederland-SEIN, Heemstede, The Netherlands; NIHR University College London Hospitals Biomedical Research Centre, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK.
authors.forename: S
authors.initials: S
authors.lastname: Shmuely
authors.affiliation: Stichting Epilepsie Instellingen Nederland-SEIN, Heemstede, The Netherlands.
authors.forename: M
authors.initials: M
authors.lastname: van der Lende
authors.affiliation: Stichting Epilepsie Instellingen Nederland-SEIN, Heemstede, The Netherlands.
authors.forename: R J
authors.initials: RJ
authors.lastname: Lamberts
authors.affiliation: Stichting Epilepsie Instellingen Nederland-SEIN, Heemstede, The Netherlands; NIHR University College London Hospitals Biomedical Research Centre, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK.
authors.forename: J W
authors.initials: JW
authors.lastname: Sander
authors.affiliation: Stichting Epilepsie Instellingen Nederland-SEIN, Heemstede, The Netherlands; NIHR University College London Hospitals Biomedical Research Centre, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK; Department of Neurology, LUMC Leiden University Medical Centre, Leiden, The Netherlands. Electronic address: rthijs@sein.nl.
authors.forename: R D
authors.initials: RD
authors.lastname: Thijs
mesh_terms: D000927:Anticonvulsants / Q000627:therapeutic use; D004827:Epilepsy / Q000188:drug therapy / Q000453:epidemiology*; D006331:Heart Diseases / Q000453:epidemiology*; D006801:Humans; D012307:Risk Factors
chemical_list: D000927:Anticonvulsants
keywords: Arrhythmia; Cardiac; Cardiovascular; Comorbidity; Epilepsy; Seizures