title: Urinary arsenic, pesticides, heavy metals, phthalates, polyaromatic hydrocarbons, and polyfluoroalkyl compounds are associated with sleep troubles in adults: USA NHANES, 2005-2006.
abstract: Links between environmental chemicals and human health have emerged, but the effects on sleep health were less studied. Therefore, the aim of the present study was to investigate the relationships of different sets of environmental chemicals and common sleep troubles in a national and population-based setting. Data were retrieved from the United States National Health and Nutrition Examination Surveys, 2005-2006 including demographics, serum measurements, lifestyle factors, self-reported sleep troubles, and urinary environmental chemical concentrations. Statistical analyses including descriptive statistics, t-test, chi-square test, and survey-weighted logistic regression models were performed. Of all 5563 Americans aged 18-85, 2331 (42.0%) had wake-up at night, 2914 (52.5%) felt unrested during the day, 740 (13.4%) had leg jerks while sleeping, and 1059 (19.1%) had leg cramps for 2+ times a month. Higher levels of urinary arsenic, phthalates, and polyfluoroalkyl compounds were associated with wake-up at night. Higher levels of urinary 4-tert-octylphenol and polyfluoroalkyl compounds were associated with being unrested during the day. Higher levels of urinary arsenic, polyaromatic hydrocarbons, and polyfluoroalkyl compounds were associated with leg jerks while sleeping. Higher levels of urinary pesticides, heavy metals, phthalates, and polyaromatic hydrocarbons were associated with leg cramps while sleeping. However, there were no significant associations with other environmental chemicals such as parabens, bisphenol A, benzophenone-3, triclosan, perchlorate, nitrate, or thiocyanate. Eliminating arsenic, heavy metals, phthalate, pesticides, polyaromatic hydrocarbons, and polyfluoroalkyl compounds to improve sleep health might be considered while understanding the biological pathway with a longitudinal or experimental approach in future research would be suggested.
authors.affiliation: Faculty of Health and Life Sciences, Northumbria University, Benton, Newcastle upon Tyne, England, NE7 7XA, UK. ivy.shiue@northumbria.ac.uk.|Owens Institute for Behavioral Research, University of Georgia, Athens, GA, USA. ivy.shiue@northumbria.ac.uk.
authors.forename: Ivy
authors.initials: I
authors.lastname: Shiue
mesh_terms: D001151:Arsenic / Q000633:toxicity*; D001559:Benzhydryl Compounds / Q000032:analysis; D001577:Benzophenones / Q000032:analysis; D004781:Environmental Exposure / Q000032:analysis; D006801:Humans; D006841:Hydrocarbons, Aromatic / Q000633:toxicity*; D016015:Logistic Models; D019216:Metals, Heavy / Q000633:toxicity*; D009566:Nitrates / Q000032:analysis; D009749:Nutrition Surveys; D010226:Parabens / Q000378:metabolism; D010472:Perchlorates; D010575:Pesticides / Q000633:toxicity*; D010636:Phenols / Q000032:analysis; D010795:Phthalic Acids / Q000633:toxicity*; D057566:Self Report; D012893:Sleep Wake Disorders; D013861:Thiocyanates; D014481:United States; D000098826:Bisphenol A Compounds
chemical_list: D001151:Arsenic; D001559:Benzhydryl Compounds; D001577:Benzophenones; D006841:Hydrocarbons, Aromatic; D019216:Metals, Heavy; D009566:Nitrates; D010226:Parabens; D010472:Perchlorates; D010575:Pesticides; D010636:Phenols; D010795:Phthalic Acids; D013861:Thiocyanates; C474055:octylphenol; C005290:oxybenzone; C105260:4-tert-octylphenol; C006780:bisphenol A; D000098826:Bisphenol A Compounds; C031760:thiocyanate; C494474:perchlorate
keywords: Arsenic; Environmental chemical; Heavy metal; Hydrocarbon; Pesticide; Phenol; Phthalate; Polyfluoroalkyl; Sleep