title: [Comparison of FibroTouch and acoustic radiation force impulse in diagnosis of liver fibrosis in patients with chronic hepatitis B].
abstract: Objective:To compare transient elastorgaphy (FibroTouch) and acoustic radiation force impulse (ARFI) in diagnosis of liver fibrosis in patients with chronic hepatitis B.Methods:One hundred and forty five patients with chronic hepatitis B underwent FibroTouch and ARFI examinations in Xixi Hospital of Hangzhou from January to November 2015. The liver stiffness (LSM) was detected by FibroTouch and the liver shear wave velocity (VTQ) was detected by ARFI; liver biopsy was performed in all patients. With biopsy results as gold standards, the diagnostic values of FibroTouch and ARFI for liver fibrosis were analyzed with Spearman correlation analysis and receiver operating characteristic (ROC) curve.Results:The correlation coefficient of FibroTouch and ARFI was 0.746 (P<0.01). FibroTouch and ARFI were significantly correlated with pathological stage determined by liver biopsy(r=0.705 and 0.727, allP<0.01). When 8.4 kPa was taken as the cut-off value of LSM and 1.49 m/s was taken as the cut-off value of VTQ, the areas under ROC (AUCs) were 0.857 and 0.836 (P>0.05) in diagnosis of fibrosis S≥2 stage; when 10.8 kPa of LSM and 1.49 m/s of VTQ were used as cut-off values, the AUCs were 0.872 and 0.881 (P>0.05) in diagnosis of S≥3 stage; when 12.3 kPa of LSM and 1.81m/s of VTQ were used as cut-off values, the AUCs were 0.875 and 0.888 (P>0.05) in diagnosis of S=4 stage.Conclusion:Both FibroTouch and ARFI can be effectively used in evaluation of liver fibrosis in patients with chronic hepatitis B.
authors.affiliation: Department of Ultrasound, Xixi Hospital of Hangzhou, Hangzhou 310023, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Liu
authors.affiliation: Department of Ultrasound, Xixi Hospital of Hangzhou, Hangzhou 310023, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Wei
authors.affiliation: Department of Ultrasound, Xixi Hospital of Hangzhou, Hangzhou 310023, China.
authors.forename: Shanshan
authors.initials: S
authors.lastname: Wang
authors.affiliation: Department of Ultrasound, Xixi Hospital of Hangzhou, Hangzhou 310023, China. Hb2k@163.com.
authors.forename: Bin
authors.initials: B
authors.lastname: Huang
mesh_terms: D001706:Biopsy; D054459:Elasticity Imaging Techniques / Q000295:instrumentation* / Q000379:methods*; D019694:Hepatitis B, Chronic / Q000150:complications / Q000000981:diagnostic imaging*; D006801:Humans; D008103:Liver Cirrhosis / Q000000981:diagnostic imaging* / Q000209:etiology; D011237:Predictive Value of Tests; D012372:ROC Curve