title: [Expression of LncRNA AK09398 and Relationship with Prognosis in Patients with Small Cell Lung Cancer].
abstract: BACKGROUND
  Small cell lung cancer (SCLC) accounts for approximately 15% of lung cancer. The poor prognosis of SCLC patients is attributed to the early blood and lymph node metastasis. However, the mechanism of SCLC is still unclear. Recent studies show that LncRNA plays an important role in the development, metastasis, and apoptosis of tumor. Thus, the present study aimed to investigate the expression and clinical significance of LncRNA AK09398 in SCLC.
  
  
  METHODS
  Quantitative reverse transcription polymerase chain reaction (qRT-PCR) was used to detect the expression of LncRNA AK09398 in 118 cases of SCLC and non-cancerous tissues. qRT-PCR was also utilized to analyze the relationship between the expression and clinical pathological characteristics and prognosis of SCLC.
  
  
  RESULTS
  The expression of LncRNA AK09398 in lung cancer tissues was (7.813±0.373). This value was significantly increased in paracarcinoma tissues (1.782±0.116) and normal lung tissues (1.209±0.200). The difference was statistically significant (F=58.41, P<0.001). AK09398 expression was positively correlated with disease stage, lymph node and distant metastasis, chemosensitivity, and survival status (P<0.05). However, AK09398 expression was not associated with gender and age (P>0.05). Kaplan-Meier analysis demonstrated that high expression level of AK09398 contributed to poor overall survival (P<0.001) and progression-free survival (P<0.001). The multivariate survival analysis also indicated that AK09398 expression, disease stage, and distant metastasis could be independent prognostic markers.
  
  
  CONCLUSIONS
  LncRNA AK09398 is involved in the development of SCLC and can be used as a molecular marker to evaluate the prognosis of SCLC. .
authors.affiliation: Department of Pulmonary Tumor Ward, Sichuan Cancer Hospital, Chengdu 610041, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Liu
authors.affiliation: Department of Pulmonary Tumor Ward, Sichuan Cancer Hospital, Chengdu 610041, China.
authors.forename: Xiaoqin
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Pulmonary Tumor Ward, Sichuan Cancer Hospital, Chengdu 610041, China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Pulmonary Tumor Ward, Sichuan Cancer Hospital, Chengdu 610041, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Ge
authors.affiliation: the Second Outpatient Department, Sichuan Cancer Hospital, Chengdu 610041, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018450:Disease Progression; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism / Q000401:mortality; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D062085:RNA, Long Noncoding / Q000235:genetics* / Q000378:metabolism; D055752:Small Cell Lung Carcinoma / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism / Q000401:mortality
chemical_list: D062085:RNA, Long Noncoding