title: Network mechanisms of hippocampal laterality, place coding, and goal-directed navigation.
abstract: The hippocampus and associated structures are responsible for episodic memory in humans. In rodents, the most prominent behavioral correlate of hippocampal neural activity is place coding, which is thought to underlie spatial navigation. While episodic memory is considered to be unique to humans in a restricted context, it has been proposed that the same neural circuitry and algorithms that enable spatial coding and navigation also support episodic memory. Here we review the recent progress in neural circuit mechanisms of hippocampal activity by introducing several topics: (1) cooperation and specialization of the bilateral hippocampi, (2) the role of synaptic plasticity in gamma phase-locking of spikes and place cell formation, (3) impaired goal-related activity and oscillations in a mouse model of mental disorders, and (4) a prefrontal-thalamo-hippocampal circuit for goal-directed spatial navigation.
authors.affiliation: Department of Physiology, Osaka City University Graduate School of Medicine, Asahimachi 1-4-3, Abeno-ku, Osaka, 545-8585, Japan.|Center for Brain Science, Osaka City University Graduate School of Medicine, Asahimachi 1-4-3, Abeno-ku, Osaka, 545-8585, Japan.
authors.forename: Takuma
authors.initials: T
authors.lastname: Kitanishi
authors.affiliation: Max Planck Institute for Brain Research, 60438, Frankfurt am Main, Germany.
authors.forename: Hiroshi T
authors.initials: HT
authors.lastname: Ito
authors.affiliation: Frontier Research Center for Post-genome Science and Technology, Hokkaido University, Hokkaido, 001-0021, Japan.
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Hayashi
authors.affiliation: Laboratory for Neuron-Glia Circuitry, RIKEN Brain Science Institute, Saitama, 351-0198, Japan.
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Shinohara
authors.affiliation: Department of Physiology, Osaka City University Graduate School of Medicine, Asahimachi 1-4-3, Abeno-ku, Osaka, 545-8585, Japan. mizuseki.kenji@med.osaka-cu.ac.jp.|Center for Brain Science, Osaka City University Graduate School of Medicine, Asahimachi 1-4-3, Abeno-ku, Osaka, 545-8585, Japan. mizuseki.kenji@med.osaka-cu.ac.jp.
authors.forename: Kenji
authors.initials: K
authors.lastname: Mizuseki
authors.affiliation: Medical Innovation Center, Kyoto University Graduate School of Medicine, 53 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan. hikida@tk.med.kyoto-u.ac.jp.
authors.forename: Takatoshi
authors.initials: T
authors.lastname: Hikida
mesh_terms: D000818:Animals; D007839:Functional Laterality / Q000502:physiology*; D006624:Hippocampus / Q000502:physiology*; D006801:Humans; D001523:Mental Disorders / Q000503:physiopathology; D009473:Neuronal Plasticity / Q000502:physiology*; D009474:Neurons / Q000502:physiology*
keywords: Hippocampus; Left–right asymmetry; Navigation; Oscillations; Place cells; Synaptic plasticity