title: Xanthohumol from hop cones (Humulus lupulus L.) prevents ADP-induced platelet reactivity.
abstract: Hop cones (Humulus lupulus L.), very rich source of phenolic compounds, possessing anticancer, antioxidant and anti-inflammatory activities, are considered as beneficial diet ingredients improving human health. In this study, the antiplatelet action of xanthohumol (XN), the principal flavonoid in hop cones, was investigated. XN significantly attenuated ADP-induced blood platelet aggregation (97.2 ± 35.7 AU for 6 μg/ml of XN vs. 120.4 ± 30.1 AU for 0.17% dimethyl sulfoxide (DMSO), p < 0.001) and significantly reduced the expression of fibrinogen receptor (activated form of GPIIbIIIa) on platelets' surface (47.6 ± 15.8 for 1.5 μg/ml XN, 44.6 ± 17.3% for 3 μg/ml XN vs. 54.5 ± 19.2% for control or 43.3 ± 18.4% for 6 μg/ml XN vs. 49.7 ± 19.4% for 0.17% DMSO, p < 0.05 or less). These findings suggest that the phenolic compounds originating from hops (XN) have a novel role as antiplatelet agents and can likely be used as dietary supplements in prophylactic approaches.
authors.affiliation: a Department of Haemostasis and Haemostatic Disorders , Medical University of Lodz , Lodz , Poland and.
authors.forename: Boguslawa
authors.initials: B
authors.lastname: Luzak
authors.affiliation: a Department of Haemostasis and Haemostatic Disorders , Medical University of Lodz , Lodz , Poland and.
authors.forename: Hassan
authors.initials: H
authors.lastname: Kassassir
authors.affiliation: b New Chemical Syntheses Institute , Pulawy , Poland.
authors.forename: Edward
authors.initials: E
authors.lastname: Rój
authors.affiliation: a Department of Haemostasis and Haemostatic Disorders , Medical University of Lodz , Lodz , Poland and.
authors.forename: Lidia
authors.initials: L
authors.lastname: Stanczyk
authors.affiliation: a Department of Haemostasis and Haemostatic Disorders , Medical University of Lodz , Lodz , Poland and.
authors.forename: Cezary
authors.initials: C
authors.lastname: Watala
authors.affiliation: a Department of Haemostasis and Haemostatic Disorders , Medical University of Lodz , Lodz , Poland and.
authors.forename: Jacek
authors.initials: J
authors.lastname: Golanski
mesh_terms: D000328:Adult; D000818:Animals; D015415:Biomarkers / Q000097:blood / Q000378:metabolism; D019587:Dietary Supplements / Q000032:analysis / Q000191:economics; D005260:Female; D005419:Flavonoids / Q000191:economics / Q000302:isolation & purification / Q000378:metabolism*; D005525:Food-Processing Industry / Q000191:economics; D006801:Humans; D027582:Humulus / Q000737:chemistry*; D007220:Industrial Waste / Q000032:analysis* / Q000191:economics; D056626:Inflorescence / Q000737:chemistry*; D008297:Male; D008810:Mice, Inbred C57BL; D019007:P-Selectin / Q000097:blood / Q000378:metabolism; D010936:Plant Extracts / Q000737:chemistry / Q000191:economics / Q000302:isolation & purification / Q000378:metabolism; D015539:Platelet Activation; D010974:Platelet Aggregation; D010975:Platelet Aggregation Inhibitors / Q000191:economics / Q000302:isolation & purification / Q000378:metabolism*; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000037:antagonists & inhibitors / Q000378:metabolism; D011427:Propiophenones / Q000191:economics / Q000302:isolation & purification / Q000378:metabolism*; D013499:Surface Properties; D013929:Thromboxane B2 / Q000097:blood / Q000378:metabolism; D055815:Young Adult
chemical_list: D015415:Biomarkers; D005419:Flavonoids; D007220:Industrial Waste; D019007:P-Selectin; D010936:Plant Extracts; D010975:Platelet Aggregation Inhibitors; D019039:Platelet Glycoprotein GPIIb-IIIa Complex; D011427:Propiophenones; D013929:Thromboxane B2; C104536:xanthohumol
keywords: ADP-induced platelet activation; Humulus lupulus L.; Xanthohumol; blood platelet reactivity; cardiovascular diseases; spent hops