title: Vegas (Verruciform Genital-Associated) Xanthoma: A Comprehensive Literature Review.
abstract: BACKGROUND
  Verruciform xanthoma is a wart-like benign lesion. The classic histologic appearance consists of foamy histiocytes within elongated dermal papillae and epithelial acanthosis. The lesion most commonly occurs in the oral cavity, but has been reported in extra-oral sites such as the penis, scrotum, and vulva. The clinical and histologic characteristics of verruciform genital-associated (Vegas) xanthomas of the penis, scrotum, and vulva are reviewed.
  
  
  METHODS
  PubMed was used to search the following term: verruciform xanthoma. The relevant papers were obtained and reviewed.
  
  
  RESULTS
  There have been 193 cases of genital-associated verruciform xanthomas. There were 164 in men and 29 in women. Similar to verruciform xanthomas of the oral mucosa, they presented as asymptomatic lesions, demonstrated foam cells in the dermal papillae, and were typically managed successfully with surgical excision.
  
  
  CONCLUSIONS
  Verruciform xanthoma is a benign lesion characterized by a wart-like growth that is most commonly seen in the oral mucosa. Verruciform xanthomas of the genital region have been coined Vegas xanthomas. Vegas xanthomas have been reported in association with a variety of diseases, as well as in healthy individuals. Biopsy is required for diagnosis, and complete surgical excision is typically curative.
authors.affiliation: Northeast Ohio Medical University, Rootstown, OH, USA. katherinestiff@gmail.com.
authors.forename: Katherine M
authors.initials: KM
authors.lastname: Stiff
authors.affiliation: Department of Dermatology, University of California San Diego, La Jolla, CA, USA. mitehead@gmail.com.
authors.forename: Philip R
authors.initials: PR
authors.lastname: Cohen
keywords: VEGAS xanthoma; Verruciform xanthoma; Verruciform xanthoma of the penis; Verruciform xanthoma of the scrotum; Verruciform xanthoma of the vulva