title: How Wounding via Lasers Has Potential Photocarcinogenic Preventative Effects via Dermal Remodeling.
abstract: As the incidence of non-melanoma skin cancer (NMSC) is increasing, there is a growing need to identify effective preventive strategies. A recently proposed hypothesis states that NMSC photocarcinogenesis is tightly linked to insufficient insulin growth factor-1 expression by agglomerated senescent fibroblasts in geriatric dermis. This paucity of IGF-1 expression in senile skin allows basal keratinocytes to mitotically propagate their UVB-altered genome and potentially initiate an actinic neoplasm. Here we review the role of the dermal microenvironment in NMSC pathogenesis, describe the impact of fibroblast senescence on this process and discuss how laser-induced dermal wounding can be effectively used to prevent NMSC development in geriatric patients.
authors.affiliation: Department of Dermatology, Indiana University School of Medicine, 975 West Walnut Street, Rm 349, Indianapolis, IN 46202, 317-274-7115.
authors.forename: Aleksandar
authors.initials: A
authors.lastname: Krbanjevic
authors.affiliation: Department of Dermatology, Indiana University School of Medicine, 975 West Walnut Street, Rm 349, Indianapolis, IN 46202, 317-274-7115; Department of Pharmacology and Toxicology, Boonshoft School of Medicine, Wright State University, 3640 Colonel Glenn Highway, Health Sciences Bldg 207, Dayton, OH 45435-0001, 937-775-2463; Dayton Veteran Affairs Medical Center, Boonshoft School of Medicine, Wright State University, 3640 Colonel Glenn Highway, Health Sciences Bldg 207, Dayton, OH 45435-0001, 937-775-2463.
authors.forename: Jeffrey B
authors.initials: JB
authors.lastname: Travers
authors.affiliation: Department of Dermatology, Indiana University School of Medicine, 975 West Walnut Street, Rm 349, Indianapolis, IN 46202, 317-274-7115; Department of Biochemistry & Molecular Biology, Indiana University School of Medicine, 975 West Walnut Street, Rm 349, Indianapolis, IN 46202, 317-274-7115.
authors.forename: Dan F
authors.initials: DF
authors.lastname: Spandau
keywords: UVB; fibroblast senescence; fractionated laser resurfacing (FLR); insulin growth factor-1 receptor (IGF-1R); non-melanoma skin cancer (NMSC); squamous cell cancer (SCC)