title: A potentially protective role of IL-18 Binding Protein in HIV-infected Long-Term Non-Progressors.
abstract: An imbalance between IL-18 and its antagonist, IL-18 Binding Protein, occurs in the circulation of HIV-infected individuals. We show here for the first time that HIV-infected Long Term Non-Progressors (LTNPs) do not develop this imbalance, and maintain normal levels of IL-18BP in the circulation. Their circulating levels of the antagonist correlate negatively with viral loads and show a positive trend with CD4+ T cells counts. The maintenance of normal production of IL-18BP may contribute, at least in part, to the ability of LTNPs to delay AIDS progression.
authors.affiliation: Laboratory of Innate Immunity, Centre Hospitalier Universitaire (CHU) Ste-Justine Research Center/Department of Microbiology, Infectiology & Immunology, University of Montreal, Montreal, Quebec, Canada.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Iannello
authors.affiliation: Laboratory of Innate Immunity, Centre Hospitalier Universitaire (CHU) Ste-Justine Research Center/Department of Microbiology, Infectiology & Immunology, University of Montreal, Montreal, Quebec, Canada.
authors.forename: Suzanne
authors.initials: S
authors.lastname: Samarani
authors.affiliation: Laboratory of Innate Immunity, Centre Hospitalier Universitaire (CHU) Ste-Justine Research Center/Department of Microbiology, Infectiology & Immunology, University of Montreal, Montreal, Quebec, Canada.
authors.forename: Ossama
authors.initials: O
authors.lastname: Allam
authors.affiliation: Department of Biological Sciences UQAM, Montreal, Quebec, Canada.
authors.forename: Mohammad-Ali
authors.initials: MA
authors.lastname: Jenabian
authors.affiliation: Division of Hematology & Chronic Viral Service, McGill University, Montreal, Quebec, Canada.
authors.forename: Vikram
authors.initials: V
authors.lastname: Mehraj
authors.affiliation: CHU Ste-Justine Research Center/Department of Pediatrics, University of Montreal, Montreal, Quebec, Canada.
authors.forename: Devendra
authors.initials: D
authors.lastname: Amre
authors.affiliation: Division of Hematology & Chronic Viral Service, McGill University, Montreal, Quebec, Canada.
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Routy
authors.affiliation: CHUM/Department of Microbiology, Infectiology & Immunology, University of Montreal, Montreal, Quebec, Canada.
authors.forename: Cécile
authors.initials: C
authors.lastname: Tremblay
authors.affiliation: Laboratory of Innate Immunity, Centre Hospitalier Universitaire (CHU) Ste-Justine Research Center/Department of Microbiology, Infectiology & Immunology, University of Montreal, Montreal, Quebec, Canada. Electronic address: ali.ahmad@recherche-ste-justine.qc.ca.
authors.forename: Ali
authors.initials: A
authors.lastname: Ahmad
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000097:blood* / Q000276:immunology / Q000628:therapy; D018791:CD4 Lymphocyte Count; D005260:Female; D015497:HIV-1; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood* / Q000276:immunology; D008297:Male
chemical_list: D036341:Intercellular Signaling Peptides and Proteins; C118370:interleukin-18 binding protein
keywords: AIDS; HIV-1; IL-18; IL-18BP; Long-Term Non-Progressors