title: Study of serum syndecan-1 levels in a group of Egyptian juvenile systemic lupus erythematosus patients.
abstract: The aim of the study was to assess the serum levels of Syndecan-1 in a group of Egyptian juvenile systemic lupus erythematosus (JSLE) patients and to study any possible associations with disease activity, renal activity and organ damage. Serum level of Syndecan-1 was assessed in 60 Egyptian JSLE patients and 30 apparently healthy age and gender matched children using ELISA. SLE Disease Activity Index-2000 (SLEDAI-2K), renal SLEDAI-2K, renal activity score and the Systemic Lupus International Collaborating Clinics/American College of Rheumatology (SLICC/ACR) Damage Index were assessed for all patients. Serum SDC-1 levels were higher in patients with JSLE than in healthy controls (p<0.001) and were positively correlated with SLEDAI-2K (p<0.001), with renal SLEDAI score (p=0.008) and renal activity score (p=0.04). So, Syndecan-1 might be used as a marker for disease activity and renal activity in JSLE patients.
authors.affiliation: Department of Pediatrics, Kasr Al Ainy Hospital, Cairo University, Cairo, Egypt.
authors.forename: Naglaa Abd Elrahman
authors.initials: NA
authors.lastname: Mosaad
authors.affiliation: Department of Pediatrics, Kasr Al Ainy Hospital, Cairo University, Cairo, Egypt.
authors.forename: Hala Mohamed
authors.initials: HM
authors.lastname: Lotfy
authors.affiliation: Department of Pediatrics, Kasr Al Ainy Hospital, Cairo University, Cairo, Egypt.
authors.forename: Yomna Mohamed
authors.initials: YM
authors.lastname: Farag
authors.affiliation: Department of Pediatrics, Kasr Al Ainy Hospital, Cairo University, Cairo, Egypt.
authors.forename: Rasha Hossam El-Din
authors.initials: RH
authors.lastname: Mahfouz
authors.affiliation: Department of Clinical Pathology, Kasr Al Ainy Hospital, Cairo University, Cairo, Egypt. Electronic address: rasha.shaheen@kasralainy.edu.eg.
authors.forename: Rasha Mohamad Hosny
authors.initials: RM
authors.lastname: Shahin
mesh_terms: D000293:Adolescent; D000367:Age Factors; D015415:Biomarkers; D002648:Child; D002675:Child, Preschool; D018450:Disease Progression; D004534:Egypt; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood* / Q000175:diagnosis*; D008297:Male; D011379:Prognosis; D012720:Severity of Illness Index; D063189:Symptom Assessment; D053668:Syndecan-1 / Q000097:blood*
chemical_list: D015415:Biomarkers; D053668:Syndecan-1
keywords: Juvenile systemic lupus erythematosus; Lupus nephritis; Syndecan-1