title: Interplay between Hippocampal Sharp-Wave-Ripple Events and Vicarious Trial and Error Behaviors in Decision Making.
abstract: Current theories posit that memories encoded during experiences are subsequently consolidated into longer-term storage. Hippocampal sharp-wave-ripple (SWR) events have been linked to this consolidation process during sleep, but SWRs also occur during awake immobility, where their role remains unclear. We report that awake SWR rates at the reward site are inversely related to the prevalence of vicarious trial and error (VTE) behaviors, thought to be involved in deliberation processes. SWR rates were diminished immediately after VTE behaviors and an increase in the rate of SWR events at the reward site predicted a decrease in subsequent VTE behaviors at the choice point. Furthermore, SWR disruptions increased VTE behaviors. These results suggest an inverse relationship between SWRs and VTE behaviors and suggest that awake SWRs and associated planning and memory consolidation mechanisms are engaged specifically in the context of higher levels of behavioral certainty.
authors.affiliation: Graduate Program in Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA.
authors.forename: Andrew E
authors.initials: AE
authors.lastname: Papale
authors.affiliation: Graduate Program in Neuroscience, Brandeis University, Waltham, MA 02453, USA.
authors.forename: Mark C
authors.initials: MC
authors.lastname: Zielinski
authors.affiliation: HHMI, Kavli Institute for Fundamental Neuroscience, Department of Physiology and Center for Integrative Neuroscience, UCSF, San Francisco, CA 94158, USA.
authors.forename: Loren M
authors.initials: LM
authors.lastname: Frank
authors.affiliation: Neuroscience Program, Department of Psychology and Volen Center for Complex Systems, Brandeis University, Waltham, MA 02453, USA.
authors.forename: Shantanu P
authors.initials: SP
authors.lastname: Jadhav
authors.affiliation: Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address: redish@umn.edu.
authors.forename: A David
authors.initials: AD
authors.lastname: Redish
mesh_terms: D000818:Animals; D001522:Behavior, Animal; D058256:Brain Waves / Q000502:physiology*; D003657:Decision Making / Q000502:physiology*; D006624:Hippocampus / Q000502:physiology*; D051381:Rats; D012890:Sleep; D014851:Wakefulness