title: Phosphorus as predictive factor for erectile dysfunction in middle aged men: A cross sectional study in Korea.
abstract: High serum inorganic phosphorus level is related with atherosclerosis and an elevated risk of cardiovascular disease. At the same time, the association of phosphorus with erectile dysfunction (ED) is not well reported. We studied the effect of serum phosphorus on ED and the relationship with other clinical variables.
  
  
  
  From March to September 2013, 1,899 police men aged 40 to 59 years who entered in a prostate health screening were targeted. All subjects underwent a clinical checking using the International Index of Erectile Function-5 (IIEF-5) questionnaire translated into Korean. Serum prostate-specific antigen (PSA), testosterone, inorganic phosphorus, body mass index, metabolic syndrome (MetS), and prostate ultrasound were also examined.
  
  
  
  Serum inorganic phosphorus (r=-0.108, p<0.001) had the highest correlation coefficient with IIEF-5 score other than age, followed by prostate volume (PV) (r=-0.065, P<0.001). Using logistic regression analysis, age, phosphorus, and MetS were predictive factors for moderate to severe ED in univariate analysis. PSA, testosterone, body mass index, and PV could not predict ED. Age, MetS, and phosphorus were independent predictive factors of moderate to severe ED (p<0.001; odds ratio [OR], 1.119; 95% confidence interval [CI] 1.086-1.153; p=0.048; OR, 1.283; 95% CI, 1.003-1.641; and p=0.048; OR, 1.101; 95% CI, 1.076-1.131) in the multivariate analysis.
  
  
  
  In our study, phosphorus level is related with ED. Phosphorus is a significant predictor of ED and a strong factor that can be modified in the middle-age. Controlling phosphorus in men may have a particular meaning of preventing the occurrence of ED.
authors.affiliation: Department of Urology, National Police Hospital, Seoul, Korea.
authors.forename: Seung Ki
authors.initials: SK
authors.lastname: Min
authors.affiliation: Department of Urology, National Police Hospital, Seoul, Korea.
authors.forename: Kwibok
authors.initials: K
authors.lastname: Choi
authors.affiliation: Department of Urology, National Police Hospital, Seoul, Korea.
authors.forename: Soon Ki
authors.initials: SK
authors.lastname: Kim
authors.affiliation: Department of Laboratory Medicine, National Police Hospital, Seoul, Korea.
authors.forename: Gyeong In
authors.initials: GI
authors.lastname: Lee
authors.affiliation: Department of Urology, National Police Hospital, Seoul, Korea.
authors.forename: In-Chang
authors.initials: IC
authors.lastname: Cho
mesh_terms: D000328:Adult; D000367:Age Factors; D015415:Biomarkers / Q000097:blood; D003430:Cross-Sectional Studies; D007172:Erectile Dysfunction / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications; D008875:Middle Aged; D010758:Phosphorus / Q000097:blood*; D011237:Predictive Value of Tests; D011467:Prostate / Q000473:pathology; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers; D010758:Phosphorus
keywords: Erectile dysfunction; Men; Middle aged; Phosphorus