title: Association Between PAI-1 Activity Levels and t-PA Antigen with Glycemic Status in Prediabetic Population.
abstract: OBJECTIVE
  to evaluate an association between fibrinolysis defect and glycemic status in prediabetic population by assessing the levels of t-PA antigen and PAI-1 activity.
  
  
  METHODS
  it was an observational study with cross-sectional approach. There were 72 subjects aged 30-50 years who had met the inclusion criteria. The diagnosis of diabetes mellitus (DM) and glycemic index were determined based on the American Diabetes Association (ADA) criteria. The PAI-1 and t-PA antigen levels were measured quantitatively using enzyme-linked immunosorbent assay (ELISA). Analysis between the levels of t-PA antigen and PAI-1 activity was performed using ANOVA.
  
  
  RESULTS
  the t-PA antigen level was significantly higher in subjects with impaired glucose tolerance (IGT) and impaired fasting blood glucose (IFBG) as well as subject with impaired fasting blood glucose (IFBG) than those with normal glucose tolerance (NGT) (p=0.047). The PAI-1 activity was significantly higher in subjects with IGT, IFBG and subjects with IFBG than NGT (p=0.024). There was a significant association between glycemic status in prediabetic subjects and PAI-1 activity (p=0.04).
  
  
  CONCLUSIONS
  the level of t-PA antigen and PAI-1 activity were significantly higher in prediabetic subjects than those with NGT; and there was a significant association between glycemic status in prediabetic subjects and PAI-1 activity.
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia. andifach@yahoo.co.id.
authors.forename: Andi Fachruddin
authors.initials: AF
authors.lastname: Benyamin
authors.forename: Dimas
authors.initials: D
authors.lastname: Bayu
authors.forename: Rahmawati
authors.initials: R
authors.lastname: Minhajat
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D003430:Cross-Sectional Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017395:Plasminogen Activator Inhibitor 1 / Q000378:metabolism*; D011236:Prediabetic State / Q000378:metabolism*; D019396:Tissue Polypeptide Antigen / Q000378:metabolism*
chemical_list: D001786:Blood Glucose; D017395:Plasminogen Activator Inhibitor 1; D019396:Tissue Polypeptide Antigen
keywords: fibrinolytic defect; plasminogen activator inhibitor-1 (PAI-1); prediabetic; tissue-type plasminogen activator (t-PA) antigen