title: Exposing the Unique Connection between Metabolism and Virulence in Staphylococcus aureus.
abstract: In this issue of Cell Chemical Biology, Choby et al. (2016) use a small molecule inhibitor active against fermenting S. aureus to unravel a unique connection between virulence factor production and central metabolism. In so doing, the authors uncover Fe-S cluster assembly proteins as a novel antibacterial target, and deliver a first-in-class scaffold for optimization against anaerobically growing cells.
authors.affiliation: Department of Cell Biology, Microbiology, and Molecular Biology, University of South Florida, 4202 East Fowler Avenue, ISA 2015, Tampa, FL 33620, USA.
authors.forename: Andy
authors.initials: A
authors.lastname: Weiss
authors.affiliation: Department of Cell Biology, Microbiology, and Molecular Biology, University of South Florida, 4202 East Fowler Avenue, ISA 2015, Tampa, FL 33620, USA.
authors.forename: Renee M
authors.initials: RM
authors.lastname: Fleeman
authors.affiliation: Department of Cell Biology, Microbiology, and Molecular Biology, University of South Florida, 4202 East Fowler Avenue, ISA 2015, Tampa, FL 33620, USA. Electronic address: shaw@usf.edu.
authors.forename: Lindsey N
authors.initials: LN
authors.lastname: Shaw
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism*; D055808:Drug Discovery; D006801:Humans; D058990:Molecular Targeted Therapy; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000821:virology; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism*; D037521:Virulence Factors / Q000037:antagonists & inhibitors / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D037521:Virulence Factors