title: Correlation between Diastolic Function and Endothelial Function in Patients with Type 2 Diabetes and Hypertension.
abstract: BACKGROUND
  Endothelial dysfunction may be involved in the pathophysiology of cardiac abnormalities in patients with diabetes mellitus (DM). A correlation between endothelial dysfunction and diastolic dysfunction in patients with type 1 DM has been demonstrated, but this relationship has not been well investigated in type 2 DM.
  
  
  OBJECTIVE
  Compare groups of patients with type 2 DM and hypertension with and without diastolic dysfunction using endothelial function indexes, and to assess whether correlations exist between the diastolic function and the endothelial function indexes.
  
  
  METHODS
  This was a cross-sectional study of 34 men and women with type 2 DM and hypertension who were aged between 40 and 70 years and were categorized based on assessments of their Doppler echocardiographic parameters as having normal (14 patients) and abnormal (20 patients) diastolic function. Flow-mediated dilatation (FMD) assessments of the brachial artery evaluated the patients' endothelial function.
  
  
  RESULTS
  The mean maximum FMD was 7.15 ± 2.80% for the patients with diastolic dysfunction and it was 11.85 ± 4.77% for the patients with normal diastolic function (p = 0.004). Correlations existed between the maximum FMD and the E/e' ratio (p = 0.040, r = -0.354) and the early wave velocity (e') at the lateral mitral annulus (p = 0.002, r = 0.509).
  
  
  CONCLUSIONS
  The endothelial function assessed by FMD was worse in hypertensive diabetic patients with diastolic dysfunction. There were correlations between the diastolic function indexes and the endothelial function indexes in our sample.
authors.affiliation: Department of Clinical Medicine, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
authors.forename: Ricardo
authors.initials: R
authors.lastname: Bedirian
authors.affiliation: Department of Clinical Medicine, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
authors.forename: Mario Fritsch
authors.initials: MF
authors.lastname: Neves
authors.affiliation: Department of Clinical Medicine, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
authors.forename: Wille
authors.initials: W
authors.lastname: Oigman
authors.affiliation: Department of Clinical Medicine, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
authors.forename: Ronaldo Altenburg Odebrecht Curi
authors.initials: RA
authors.lastname: Gismondi
authors.affiliation: Department of Clinical Medicine, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
authors.forename: Cesar Romaro
authors.initials: CR
authors.lastname: Pozzobon
authors.affiliation: Department of Clinical Medicine, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
authors.forename: Marcia Cristina Boaventura
authors.initials: MC
authors.lastname: Ladeira
authors.affiliation: Department of Medical Specialties, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
authors.forename: Marcia Bueno
authors.initials: MB
authors.lastname: Castier
keywords: Arterial intima; Diabetes mellitus; Diastole; Doppler echocardiography; Doppler ultrasonography; Endothelium; Hypertension; Left ventricle