title: Structure-activity relationship studies for multitarget antithrombotic drugs.
abstract: Thrombosis is a complex process involving multiple pathways. Currently, therapy relies on the combination of two or more antithrombotic drugs, showing that inhibiting more than one target provides benefits in the prevention and treatment of thrombosis. This review focuses on structure-activity relationship studies of molecules possessing multiple actions against thrombosis, namely, dual inhibitors of coagulation, dual inhibitors of coagulation and platelet aggregation, and also dual inhibitors of platelet aggregation. EP217609 has just entered clinical trials, which raise the expectations on the multitarget strategy to prevent or treat thrombosis.
authors.affiliation: Organic Chemistry & Pharmaceutical Laboratory, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira 228, Porto 4050-313, Portugal.
authors.forename: Ana R
authors.initials: AR
authors.lastname: Neves
authors.affiliation: Organic Chemistry & Pharmaceutical Laboratory, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira 228, Porto 4050-313, Portugal.|Interdisciplinary Centre of Marine & Environmental Research (CIIMAR/CIMAR), University of Porto, Rua dos Bragas 289, Porto 4050-123, Portugal.
authors.forename: Marta
authors.initials: M
authors.lastname: Correia-da-Silva
authors.affiliation: Organic Chemistry & Pharmaceutical Laboratory, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira 228, Porto 4050-313, Portugal.|Interdisciplinary Centre of Marine & Environmental Research (CIIMAR/CIMAR), University of Porto, Rua dos Bragas 289, Porto 4050-123, Portugal.
authors.forename: Emília
authors.initials: E
authors.lastname: Sousa
authors.affiliation: Organic Chemistry & Pharmaceutical Laboratory, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira 228, Porto 4050-313, Portugal.|Interdisciplinary Centre of Marine & Environmental Research (CIIMAR/CIMAR), University of Porto, Rua dos Bragas 289, Porto 4050-123, Portugal.
authors.forename: Madalena
authors.initials: M
authors.lastname: Pinto
mesh_terms: D005343:Fibrinolytic Agents / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D010974:Platelet Aggregation / Q000187:drug effects; D013329:Structure-Activity Relationship; D013927:Thrombosis / Q000188:drug therapy*
chemical_list: D005343:Fibrinolytic Agents
keywords: anticoagulant; antiplatelet; multitarget; structure–activity relationships; thrombosis