title: Ultrasound assessment of thyroid gland volume in diabetic patients without overt thyroid disease.
abstract: BACKGROUND
  Diabetes mellitus and thyroid disease are known to mutually influence each other. Thyroid disease can worsen glycaemic control in diabetes, and patients with diabetes mellitus have increased incidence of thyroid disorders such as increase in size, compared to the normal population.
  
  
  OBJECTIVE
  The aim of the study was to sonographically assess thyroid gland volume in Nigerian adult diabetic patients and compare with apparently healthy adults (controls).
  
  
  METHODS
  The study setting was the Department of Radiology, University of Benin Teaching Hospital (UBTH) Nigeria. The thyroid gland in 120 diabetic subjects and equal number of apparently healthy controls was scanned with a 5-12 MHz linear transducer of a SONOACE X4 Machine. Thyroid gland volume was assessed. Statistical analysis was done with Statistical Package for the Social Sciences (SPSS) version 17 (SPSS Inc, Chicago, IL, USA).
  
  
  RESULTS
  Diabetics had significantly increased thyroid volume compared to age matched male and female control subjects (11.5 ± 5.2 cm3 vs 7.4 ± 1.9 cm3; P< 0.001 for males) and (9.9 ± 6.2 cm3 vs 7.1 ± 3.4 cm3; P< 0.001 for females) respectively. Gender did not significantly influence thyroid volume among diabetics.
  
  
  CONCLUSIONS
  Diabetics have higher thyroid gland dimensions, compared to apparently healthy subjects. Gland proliferation from circulating insulin may play a role. This is not influenced by gender.
authors.affiliation: Department of Radiology, University of Benin Teaching Hospital, Benin City, Nigeria.
authors.forename: Christopher C
authors.initials: CC
authors.lastname: Nduka
authors.affiliation: Department of Radiology, University of Benin Teaching Hospital, Benin City, Nigeria.
authors.forename: Ademola A
authors.initials: AA
authors.lastname: Adeyekun
mesh_terms: D000328:Adult; D000368:Aged; D015992:Body Mass Index; D001830:Body Surface Area; D016022:Case-Control Studies; D003920:Diabetes Mellitus / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D011446:Prospective Studies; D013961:Thyroid Gland / Q000000981:diagnostic imaging* / Q000473:pathology; D014463:Ultrasonography; D055815:Young Adult