title: Genetic diversity and haplotypic structure of Chinese Kazak ethnic group revealed by 19 STRs on the X chromosome.
abstract: X-chromosomal short tandem repeats (X-STRs) have been widely used in forensic practices involving complicated ties of kinship over the past years, and also play an increasingly important role in population genetics. To study the genetic polymorphisms of 19 STR loci on X chromosome in Chinese Kazak ethnic group, we investigated the allelic and haplotypic frequencies of the 19 loci in 300 (149 males and 151 females) unrelated healthy individuals from Ili Kazak Autonomous Prefecture, Xinjiang Uigur Autonomous Region of China after having evaluated the forensic application value of these loci in forensic sciences, and then compared the population distinctions between the Kazak group and other reference groups. We observed a total of 240 alleles at these X-STR loci with the corresponding allelic frequencies ranging from 0.0017 to 0.5917. In the study, the highest polymorphism was found at DXS10135 locus. The combined power of discrimination in females was 0.999999999999999999999985 and in males 0.999999999999968. The present study indicates that the 19 X-STR loci are very useful for both forensic identification cases and kinship analyses involving a female offspring.
authors.affiliation: Department of Forensic Genetics, School of Forensic Medicine, Southern Medical University, Guangzhou, Guangdong 510515, PR China; Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi 710004, PR China; Department of Biochemistry, Preclinical Medicine College, Xinjiang Medical University, Urumqi 830011, PR China.
authors.forename: Yao-Shun
authors.initials: YS
authors.lastname: Liu
authors.affiliation: Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi 710004, PR China.
authors.forename: Hao-Tian
authors.initials: HT
authors.lastname: Meng
authors.affiliation: Department of Biochemistry, Preclinical Medicine College, Xinjiang Medical University, Urumqi 830011, PR China.
authors.forename: Ting
authors.initials: T
authors.lastname: Mei
authors.affiliation: Department of Biochemistry, Preclinical Medicine College, Xinjiang Medical University, Urumqi 830011, PR China.
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Zhang
authors.affiliation: Department of Biochemistry, Preclinical Medicine College, Xinjiang Medical University, Urumqi 830011, PR China.
authors.forename: Jian-Gang
authors.initials: JG
authors.lastname: Chen
authors.affiliation: Anhui Public Security Bureau Evidence Identification Center, Anhui 518054, PR China.
authors.forename: Yu-Dang
authors.initials: YD
authors.lastname: Zhang
authors.affiliation: Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, PR China.
authors.forename: Jing
authors.initials: J
authors.lastname: Chen
authors.affiliation: Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi 710004, PR China.
authors.forename: Yu-Xin
authors.initials: YX
authors.lastname: Guo
authors.affiliation: Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi 710004, PR China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Dong
authors.affiliation: Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, PR China.
authors.forename: Jiang-Wei
authors.initials: JW
authors.lastname: Yan
authors.affiliation: Department of Forensic Genetics, School of Forensic Medicine, Southern Medical University, Guangzhou, Guangdong 510515, PR China. Electronic address: zhubofeng7372@126.com.
authors.forename: Bo-Feng
authors.initials: BF
authors.lastname: Zhu
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics*; D002681:China; D041321:Chromosomes, Human, X / Q000235:genetics*; D005006:Ethnicity / Q000235:genetics*; D005260:Female; D053803:Forensic Genetics; D005787:Gene Frequency; D005819:Genetic Markers; D014644:Genetic Variation; D005828:Genetics, Population; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D018895:Microsatellite Repeats; D010375:Pedigree; D010802:Phylogeny; D011110:Polymorphism, Genetic
chemical_list: D005819:Genetic Markers
keywords: Genetic polymorphisms; Haplotypic structure; Kazak ethnic group; X-STRs