title: Vitamin D3a new drug against Candida albicans.
abstract: OBJECTIVE
  In this study, we demonstrate that vitamin D3had fungicidal activity against Candida albicans.
  
  
  METHODS
  The susceptibility of the yeast strain to the vitamin D3was investigated by the antimicrobial screening using modified agar diffusion method, minimum fungistatic concentrations (MFCs) and minimum fungicide concentrations (MFCC) of the vitamin D3were determined by the broth dilution method.
  
  
  RESULTS
  The antifungal activity indicted that 100μg/ml of vitamin D3had a power inhibition in the growth of C. albicans with zone of inhibition 12.5mm and CMFCand CMFswere 1.58±0.0764μg/ml.
  
  
  CONCLUSIONS
  These values indicate that vitamin D3can be considered to have fungicide activity. This antifungal effect may be due to the large lipsolubility of vitamin D3changing the integrity of the cell membrane.
authors.affiliation: Laboratory of applied microbiology, faculty of nature and life sciences, university Ferhat Abbas Sétif 1, Sétif, Algeria. Electronic address: bouzid.djihane@yahoo.fr.
authors.forename: D
authors.initials: D
authors.lastname: Bouzid
authors.affiliation: Laboratory Bouchara Recordati, Alpha Consult, Algeria. Electronic address: drmerzouki_s@yahoo.fr.
authors.forename: S
authors.initials: S
authors.lastname: Merzouki
authors.affiliation: Laboratory of microbiology, faculty of sciences, university Mohamed boudiaf, M'sila, Algeria.
authors.forename: M
authors.initials: M
authors.lastname: Bachiri
authors.affiliation: Laboratory of microbiology, faculty of sciences, university Mohamed boudiaf, M'sila, Algeria.
authors.forename: S E
authors.initials: SE
authors.lastname: Ailane
authors.affiliation: Laboratory of applied microbiology, faculty of nature and life sciences, university Ferhat Abbas Sétif 1, Sétif, Algeria. Electronic address: med.zerroug@gmail.com.
authors.forename: M M
authors.initials: MM
authors.lastname: Zerroug
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects* / Q000254:growth & development; D002762:Cholecalciferol / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008826:Microbial Sensitivity Tests
chemical_list: D000935:Antifungal Agents; D002762:Cholecalciferol
keywords: Activité fongicide; Candida albicans; Concentrations minimales fongicide (MFC(c)); Concentrations minimales fongistatiques (MFC(s)); Fungicidal activity; Minimum fungicide concentrations (MFC(c)); Minimum fungistatic concentrations (MFC(s)); Vitamin D(3); Vitamine D(3)