title: A ComparativeIn SilicoStudy of the Antioxidant Defense Gene Repertoire of Distinct Lifestyle Trypanosomatid Species.
abstract: Kinetoplastids are an ancestral group of protists that contains free-living species and parasites with distinct mechanisms in response to stress. Here, we compared genes involved in antioxidant defense (AD), proposing an evolution model among trypanosomatids. All genes were identified inBodo saltans, suggesting that AD mechanisms have evolved prior to adaptation for parasitic lifestyles. While most of the monoxenous and dixenous parasites revealed minor differences fromB. saltans, the endosymbiont-bearing species have an increased number of genes. The absence of these genes was mainly observed in the extracellular parasites of the generaPhytomonasandTrypanosoma. In trypanosomes, a distinction was observed between stercorarian and salivarian parasites, except forTrypanosoma rangeli. Our analyses indicate that the variability of AD among trypanosomatids at the genomic level is not solely due to the geographical isolation, being mainly related to specific adaptations of their distinct biological cycles within insect vectors and to a parasitism of a wide range of hosts.
authors.affiliation: Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil.; Universidade do Sul de Santa Catarina, Palhoça, SC, Brazil.
authors.forename: Ingrid Thaís
authors.initials: IT
authors.lastname: Beltrame-Botelho
authors.affiliation: Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Carlos
authors.initials: C
authors.lastname: Talavera-López
authors.affiliation: Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Björn
authors.initials: B
authors.lastname: Andersson
authors.affiliation: Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil.
authors.forename: Edmundo Carlos
authors.initials: EC
authors.lastname: Grisard
authors.affiliation: Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil.
authors.forename: Patricia Hermes
authors.initials: PH
authors.lastname: Stoco
keywords: Kinetoplastea; antioxidant system; evolution; trypanosomatids