title: Cerebral small vessel disease and post-stroke cognitive impairment.
abstract: Cerebral small vessel disease (CSVD) refers to a group of pathological processes with multifarious etiologies that affect the small arteries, arterioles, venules, and capillaries of the brain. Features seen on neuroimaging include white matter hyperintensities, lacunar infarction, cerebral microbleeds, brain atrophy, microinfarcts and enlarged perivascular spaces (EPVS). CSVD gives rise to one in five strokes worldwide and is a leading cause of cognitive impairment and dementia, especially in the elderly. Post-stroke cognitive impairment (PSCI) is one of the most common subtypes of cognitive impairment. The underlying mechanisms of PSCI are not known in detail. A growing body of evidence has been suggesting that CSVD plays an important role in the pathogenesis of PSCI. This article reviews the advances in research on the relationship between CSVD and PSCI.
authors.affiliation: a Department of Neurology , Hebei General Hospital , Shijiazhuang , P. R. China.|b Graduate School , Hebei Medical University , Shijiazhuang , P. R. China.
authors.forename: Zhenjie
authors.initials: Z
authors.lastname: Teng
authors.affiliation: a Department of Neurology , Hebei General Hospital , Shijiazhuang , P. R. China.
authors.forename: Yanhong
authors.initials: Y
authors.lastname: Dong
authors.affiliation: a Department of Neurology , Hebei General Hospital , Shijiazhuang , P. R. China.|b Graduate School , Hebei Medical University , Shijiazhuang , P. R. China.
authors.forename: Dandan
authors.initials: D
authors.lastname: Zhang
authors.affiliation: a Department of Neurology , Hebei General Hospital , Shijiazhuang , P. R. China.
authors.forename: Jin
authors.initials: J
authors.lastname: An
authors.affiliation: a Department of Neurology , Hebei General Hospital , Shijiazhuang , P. R. China.|b Graduate School , Hebei Medical University , Shijiazhuang , P. R. China.
authors.forename: Peiyuan
authors.initials: P
authors.lastname: Lv
mesh_terms: D059345:Cerebral Small Vessel Diseases / Q000150:complications* / Q000000981:diagnostic imaging; D003072:Cognition Disorders / Q000000981:diagnostic imaging / Q000209:etiology*; D006801:Humans; D059906:Neuroimaging; D020521:Stroke / Q000150:complications* / Q000000981:diagnostic imaging
keywords: White matter hyperintensities; cerebral microbleeds; cognitive impairment; lacunar infarct; stroke