title: Newborn hearing screening in prematurity: fate of screening failures and auditory maturation.
abstract: OBJECTIVE
  The purpose of this study was to identify delayed auditory maturation and the fate of premature infants who failed the newborn hearing screening (NHS) in neonatal intensive care unit.
  
  
  METHODS
  A total of 1375 neonates underwent NHS using the transient evoked otoacoustic emission (TEOAE) in a tertiary hospital between 2007 and 2010 according to the Joint Committee on Infant Hearing guidelines. In addition, a structured telephone survey was given to caregivers of infants who were lost to follow-up NHS. Auditory steady-state response (ASSR) threshold and the threshold change in diagnostic test failures were analysed.
  
  
  RESULTS
  Among the 1375 NICU babies, 344 (25.0%) babies, 111 (9.7%) babies and 64 (4.6%) babies failed to pass the first TEOAE, second TEOAE and diagnostic ASSR, respectively. However, at the age of about 5 years, 12 (0.9%) infants showed permanent hearing loss (PHL). The ASSR threshold improved from 69.0 ± 19.7 dB to 52.9 ± 21.6 dB in <4 months (P < 0.001). Premature infants of <29 weeks of gestational age at birth showed higher referral (P = 0.003) rate at the first OAE test compared to the others, and the difference continued until the last follow-up. The odds ratio for the initial ASSR threshold >67.5 dB for PHL was 9.00 (95% confidence interval, 1.7-46.7).
  
  
  CONCLUSIONS
  Most of first TEOAE screening failures (91.3%) showed normal hearing and speech development. Hearing levels in premature infants can improve over time, particularly in neonates with initial ASSR threshold <67.5 dB.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Chonnam National University Medical School and Chonnam National University Hospital, Gwangju, Korea.
authors.forename: H C
authors.initials: HC
authors.lastname: Yang
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Chonnam National University Medical School and Chonnam National University Hospital, Gwangju, Korea.
authors.forename: C M
authors.initials: CM
authors.lastname: Sung
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Chonnam National University Medical School and Chonnam National University Hospital, Gwangju, Korea.
authors.forename: D J
authors.initials: DJ
authors.lastname: Shin
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Chonnam National University Medical School and Chonnam National University Hospital, Gwangju, Korea.
authors.forename: Y B
authors.initials: YB
authors.lastname: Cho
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Chonnam National University Medical School and Chonnam National University Hospital, Gwangju, Korea.
authors.forename: C H
authors.initials: CH
authors.lastname: Jang
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Chonnam National University Medical School and Chonnam National University Hospital, Gwangju, Korea.
authors.forename: H-H
authors.initials: HH
authors.lastname: Cho
mesh_terms: D001309:Auditory Threshold / Q000502:physiology*; D003638:Deafness / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology*; D005260:Female; D005865:Gestational Age; D006309:Hearing / Q000502:physiology*; D006320:Hearing Tests; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000175:diagnosis* / Q000453:epidemiology / Q000503:physiopathology; D008297:Male; D015997:Neonatal Screening / Q000379:methods*; D017084:Otoacoustic Emissions, Spontaneous / Q000502:physiology*; D056910:Republic of Korea / Q000453:epidemiology; D012189:Retrospective Studies