title: Inflammasome activators induce fibronectin expression and release in macrophages.
abstract: Extracellular fibronectin (Fn) can activate pro-inflammatory pathways and serves as an endogenous danger signalling molecule; thus, it has been suggested as a biomarker for several diseases. In the present study, we found that pathogen-derived activators of the inflammasomes induce the expression and secretion of Fn in macrophages through a mechanism involving adenosine triphosphate and caspase-1 activation. We also found that plasma Fn induces caspase-1 activation and cell death in macrophages, epithelial cells, and fibroblasts. Together, these results indicate that Fn plays a critical role in inflammasome-activated cells by amplifying caspase-1 activation and inducing inflammatory cell death.
authors.forename: Hye-Kyoung
authors.initials: HK
authors.lastname: Jun
authors.forename: Young-Jung
authors.initials: YJ
authors.lastname: Jung
authors.affiliation: Department of Oral Microbiology and Immunology, School of Dentistry, Seoul National University, Jongno-gu, Seoul, South Korea.|Dental Research Institute, School of Dentistry, Seoul National University, Jongno-gu, Seoul, South Korea.
authors.forename: Bong-Kyu
authors.initials: BK
authors.lastname: Choi
mesh_terms: D000255:Adenosine Triphosphate / Q000502:physiology; D020170:Caspase 1 / Q000378:metabolism; D016923:Cell Death; D002460:Cell Line; D004789:Enzyme Activation; D005353:Fibronectins / Q000235:genetics / Q000378:metabolism*; D005408:Flagellin / Q000276:immunology; D006801:Humans; D058847:Inflammasomes / Q000502:physiology*; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000276:immunology / Q000378:metabolism*; D018048:Receptors, Purinergic P2 / Q000378:metabolism; D012486:Salmonella typhimurium / Q000276:immunology; D015398:Signal Transduction; D015533:Transcriptional Activation / Q000276:immunology*
chemical_list: C067625:FN1 protein, human; D005353:Fibronectins; D058847:Inflammasomes; D008070:Lipopolysaccharides; D018048:Receptors, Purinergic P2; D005408:Flagellin; D000255:Adenosine Triphosphate; D020170:Caspase 1
keywords: ATP; caspase-1; cell death; fibronectin; inflammasome activators