title: Trends in the presentation, treatment, and survival of patients with medullary thyroid cancer over the past 30 years.
abstract: The impact of recent medical advances on disease presentation, extent of operation, and disease-specific survival for patients with medullary thyroid cancer is unclear.
  
  
  
  We used the Surveillance, Epidemiology, and End Results registry to compare trends over 3 time periods, 1983-1992, 1993-2002, and 2003-2012.
  
  
  
  There were 2,940 patients diagnosed with medullary thyroid cancer between 1983 and 2012. The incidence of medullary thyroid cancer increased during this time period from 0.14 to 0.21 per 100,000 population, and mean age at diagnosis increased from 49.8 to 53.8 (P < .001). The proportion of tumors ≤1 cm also increased from 11.4% in 1983-1992, 19.6% in 1993-2002, to 25.1% in 2003-2012 (P < .001), but stage at diagnosis remained constant (P = .57). In addition, the proportion of patients undergoing a total thyroidectomy and lymph node dissection increased from 58.2% to 76.5% during the study period (P < .001). In the most recent time interval, 5-year, disease-specific survival improved from 86% to 89% in all patients (P < .001) but especially for patients with regional (82% to 91%, P = .003) and distant (40% to 51%, P = .02) disease.
  
  
  
  These data demonstrate that the extent of operation is increasing for patients with medullary thyroid cancer. Disease-specific survival is also improving, primarily in patients with regional and distant disease.
authors.affiliation: Department of Surgery, University of Wisconsin, Madison, WI. Electronic address: randle@surgery.wisc.edu.
authors.forename: Reese W
authors.initials: RW
authors.lastname: Randle
authors.affiliation: Department of Surgery, University of Wisconsin, Madison, WI.
authors.forename: Courtney J
authors.initials: CJ
authors.lastname: Balentine
authors.affiliation: Department of Surgery, University of Wisconsin, Madison, WI.
authors.forename: Glen E
authors.initials: GE
authors.lastname: Leverson
authors.affiliation: Department of Surgery, University of Wisconsin, Madison, WI.
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Havlena
authors.affiliation: Department of Surgery, University of Wisconsin, Madison, WI.
authors.forename: Rebecca S
authors.initials: RS
authors.lastname: Sippel
authors.affiliation: Department of Surgery, University of Wisconsin, Madison, WI.
authors.forename: David F
authors.initials: DF
authors.lastname: Schneider
authors.affiliation: Department of Surgery, University of Wisconsin, Madison, WI.
authors.forename: Susan C
authors.initials: SC
authors.lastname: Pitt
mesh_terms: D000328:Adult; D000368:Aged; D018278:Carcinoma, Neuroendocrine / Q000401:mortality* / Q000473:pathology / Q000601:surgery*; D016022:Case-Control Studies; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D015994:Incidence; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000473:pathology; D009367:Neoplasm Staging; D011379:Prognosis; D012042:Registries; D012189:Retrospective Studies; D018570:Risk Assessment; D018426:SEER Program; D018709:Statistics, Nonparametric; D016019:Survival Analysis; D013964:Thyroid Neoplasms / Q000401:mortality* / Q000473:pathology / Q000601:surgery*; D013965:Thyroidectomy / Q000379:methods* / Q000401:mortality; D014481:United States