title: Restrictive cardiomyopathy : Delayed occurrence after radiotherapy of breast cancer.
abstract: A 74-year-old female patient was referred to our department in 2015 with dyspnea, cough and dysphagia. She had been diagnosed with adenocarcinoma of the right breast in 1986 and underwent mastectomy. When she presented with a local recurrence in 1988, she was receiving high-voltage radiation therapy. Transthoracic echocardiography and magnetic resonance imaging revealed tricuspid regurgitation grade III and unclear right heart failure with a massively dilated right atrium. Coronary heart disease could be ruled out. In summary, the patient's findings represented right ventricular myocardial restriction which we attributed to irradiation of the right anterior chest 17 years previously.
authors.affiliation: Department of Cardiology, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin, Hindenburgdamm 30, 12200, Berlin, Germany. barbara.bellmann@charite.de.
authors.forename: Barbara
authors.initials: B
authors.lastname: Bellmann
authors.affiliation: Department of Cardiology, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin, Hindenburgdamm 30, 12200, Berlin, Germany.
authors.forename: Brunilda
authors.initials: B
authors.lastname: Alushi
authors.affiliation: Department of Cardiology, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin, Hindenburgdamm 30, 12200, Berlin, Germany.
authors.forename: Boris
authors.initials: B
authors.lastname: Bigalke
authors.affiliation: Department of Cardiology, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin, Hindenburgdamm 30, 12200, Berlin, Germany.
authors.forename: Ulf
authors.initials: U
authors.lastname: Landmesser
authors.affiliation: Department of Cardiology, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin, Hindenburgdamm 30, 12200, Berlin, Germany.
authors.forename: Andreas J
authors.initials: AJ
authors.lastname: Morguet
mesh_terms: D000368:Aged; D001943:Breast Neoplasms / Q000453:epidemiology* / Q000532:radiotherapy*; D002313:Cardiomyopathy, Restrictive / Q000175:diagnosis / Q000209:etiology*; D015984:Causality; D015897:Comorbidity; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D015994:Incidence; D008137:Longitudinal Studies; D011832:Radiation Injuries / Q000175:diagnosis / Q000209:etiology*; D020266:Radiotherapy, Conformal / Q000009:adverse effects*; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome; D018497:Ventricular Dysfunction, Right / Q000175:diagnosis / Q000209:etiology*
keywords: Breast cancer; Radiotherapy; Restrictive cardiomyopathy; Right heart failure; Tricuspid regurgitation