title: Association of multiple genetic variants with breast cancer susceptibility in the Han Chinese population.
abstract: We selected 13 tag single nucleotide polymorphisms (tSNPs) to investigate whether they were associated with breast cancer risk in the Chinese Han population. Upon statistical analyses of clinical data from 551 patients and 577 controls, we found that six of the 13 SNPs were associated with breast cancer; namely, rs4973768(Odds ratio (OR) = 1.30, 95% confidence interval (CI) =1.01-1.67), rs981782(OR =1.30, 95% CI=1.01-1.66), rs1432679(OR =0.84, 95% CI=0.70-0.99), rs10759243(OR=1.30, 95%CI=1.09-1.55), rs10822013(OR =1.18, 95% CI=1.00-1.39) and rs704010(OR =1.63, 95% CI=1.04-2.56). When stratified based on breast cancer subtype, our analyses revealed that three SNPs (rs981782, rs10759243 and rs704010) correlated with ER+ breast cancer, while another three (rs4973768, rs1432679 and rs10822013) correlated with ER- breast cancer. We obtained similar results while investigating the correlation of SNPs with PR status or clinical stage. Our results suggest that associations identified between SNPs and breast cancer through genome-wide association studies (GWAS) may not always be generalizable across races.
authors.affiliation: Department of Oncology, First Affiliated Hospital, Xi'an Jiatong University, Xi'an, Shannxi 710061, China.|Department of The First of Internal Medicine, Tumor Hospital of Shaanxi Province Affiliated Hospital, Medical College of Xi'an Jiao Tong University, Xi'an, Shannxi 710061, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of The Fifth of Internal Medicine, Xi'an No5 Hospital, Xi'an, Shannxi 710082, China.
authors.forename: Wenjing
authors.initials: W
authors.lastname: Zou
authors.affiliation: Department of Obstetrics and Gynecology, Second Affiliated Hospital, Xi'an Jiatong University, Xi'an, Shannxi 710003, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Liu
authors.affiliation: Department of Oncological Surgery, Shaanxi Provincial People's Hospital, Xi'an 710068, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Cao
authors.affiliation: Department of Oncological Surgery, Weinan Central Hospital, Weinan, Shaanxi 714000, China.
authors.forename: Yonghong
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: Department of Oncology, Shaanxi Provincial People's Hospital, Xi'an 710068, China.
authors.forename: Gaili
authors.initials: G
authors.lastname: An
authors.affiliation: Department of The First of Internal Medicine, Tumor Hospital of Shaanxi Province Affiliated Hospital, Medical College of Xi'an Jiao Tong University, Xi'an, Shannxi 710061, China.
authors.forename: Yuzheng
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Oncology, First Affiliated Hospital, Xi'an Jiatong University, Xi'an, Shannxi 710061, China.
authors.forename: Shangke
authors.initials: S
authors.lastname: Huang
authors.affiliation: Department of Oncology, First Affiliated Hospital, Xi'an Jiatong University, Xi'an, Shannxi 710061, China.
authors.forename: Xinhan
authors.initials: X
authors.lastname: Zhao
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics; D014408:Biomarkers, Tumor / Q000032:analysis / Q000235:genetics*; D001943:Breast Neoplasms / Q000737:chemistry / Q000208:ethnology / Q000235:genetics* / Q000473:pathology; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002681:China; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D016015:Logistic Models; D008875:Middle Aged; D009367:Neoplasm Staging; D016017:Odds Ratio; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D011960:Receptors, Estrogen / Q000032:analysis; D011980:Receptors, Progesterone / Q000032:analysis; D018570:Risk Assessment; D012307:Risk Factors
chemical_list: D014408:Biomarkers, Tumor; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone
keywords: Chinese population; breast cancer; case-control study; single nucleotide polymorphism (SNP)