title: Retinal Nerve Fiber Layer Thickness Changes in Age-Related Macular Degeneration Treated with Multiple Intravitreal Ranibizumab.
abstract: The objective of this study was to investigate the effect of multiple intravitreal ranibizumab (IVR) injections on the retinal nerve fiber layer (RNFL) in neovascular age-related macular degeneration (nAMD).
  
  
  
  One hundred sixty-eight eyes of 168 patients with nAMD who received an IVR at least 3 times were included in this prospective interventional case series. The RNFL thickness data on 80 healthy eyes, used as the control group, were obtained. The patients were grouped as follows: 3-10 injections (group 1, 62 eyes, 37%), 10-20 injections (group 2, 62 eyes, 37%), and ≥20 injections (group 3, 44 eyes, 26%). The RNFL thickness was measured by spectral domain optical coherence tomography.
  
  
  
  The mean baseline measurement of the RNFL thickness was 97.4 ± 6.4 μm in the control group, 96.4 ± 5.6 μm in group 1, 93.8 ± 4.6 μm in group 2, and 93.2 ± 5.3 μm in group 3. At the last follow-up, it was 95.1 ± 2.4 μm in the control group, 93.4 ± 7.3 μm in group 1, 90.5 ± 3.6 μm in group 2, and 89.2 ± 4.9 μm in group 3 (all P values >0.050). A statistically significant difference was not found between the mean total RNFL thickness of the eyes that received injections and that of the eyes in the healthy control group (P value >0.050). A statistically significant difference was not found in all the treatment groups between the intraocular pressure level taken 1 day after the administration of the injections and that recorded preintervention (all P values >0.050).
  
  
  
  Repeated IVR did not lead to a significant change in RNFL thickness in patients with nAMD.
authors.affiliation: 1 Ophthalmology Department, Medical Faculty, T.C. Istanbul Bilim University , Istanbul, Turkey .
authors.forename: Elvan Alper
authors.initials: EA
authors.lastname: Sengul
authors.affiliation: 2 Ophthalmology Department, Istanbul Medicine Hospital , Istanbul, Turkey .
authors.forename: Ozgur
authors.initials: O
authors.lastname: Artunay
authors.affiliation: 3 Ophthalmology Department, Haydarpasa Numune Training and Research Hospital , Istanbul, Turkey .
authors.forename: Esra Turkseven
authors.initials: ET
authors.lastname: Kumral
authors.affiliation: 3 Ophthalmology Department, Haydarpasa Numune Training and Research Hospital , Istanbul, Turkey .
authors.forename: Melda
authors.initials: M
authors.lastname: Yenerel
authors.affiliation: 1 Ophthalmology Department, Medical Faculty, T.C. Istanbul Bilim University , Istanbul, Turkey .
authors.forename: Rifat
authors.initials: R
authors.lastname: Rasier
authors.affiliation: 1 Ophthalmology Department, Medical Faculty, T.C. Istanbul Bilim University , Istanbul, Turkey .
authors.forename: Alev
authors.initials: A
authors.lastname: Kockar
authors.affiliation: 1 Ophthalmology Department, Medical Faculty, T.C. Istanbul Bilim University , Istanbul, Turkey .
authors.forename: Erdal
authors.initials: E
authors.lastname: Yuzbasioglu
mesh_terms: D000367:Age Factors; D000368:Aged; D005260:Female; D006801:Humans; D058449:Intravitreal Injections; D008268:Macular Degeneration / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D009412:Nerve Fibers / Q000187:drug effects* / Q000473:pathology; D011446:Prospective Studies; D000069579:Ranibizumab / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D000069579:Ranibizumab
keywords: age-related macular degeneration; intravitreal ranibizumab; retinal nerve fiber layer