title: Receptor clustering and activation by multivalent interaction through recognition peptides presented on exosomes.
abstract: We demonstrate a novel system for inducing clustering of cell surface receptors via recognition peptide segments displayed on exosomes, leading to receptor activation. With this system, targeting of receptor-expressing cells and facilitation of the endocytic uptake of exosomes, which contained the anti-cancer protein saporin, were successfully achieved, leading to cell death.
authors.affiliation: Nanoscience and Nanotechnology Research Center, Research Organization for the 21st Century, Osaka Prefecture University, 1-2, Gakuen-cho, Naka-ku, Osaka 599-8570, Japan. i-nakase@21c.osakafu-u.ac.jp.
authors.forename: I
authors.initials: I
authors.lastname: Nakase
authors.affiliation: Nanoscience and Nanotechnology Research Center, Research Organization for the 21st Century, Osaka Prefecture University, 1-2, Gakuen-cho, Naka-ku, Osaka 599-8570, Japan. i-nakase@21c.osakafu-u.ac.jp and Graduate School of Science, Osaka Prefecture University, 1-1, Gakuen-cho, Naka-ku, Osaka 599-8531, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Ueno
authors.affiliation: Nanoscience and Nanotechnology Research Center, Research Organization for the 21st Century, Osaka Prefecture University, 1-2, Gakuen-cho, Naka-ku, Osaka 599-8570, Japan. i-nakase@21c.osakafu-u.ac.jp and Graduate School of Science, Osaka Prefecture University, 1-1, Gakuen-cho, Naka-ku, Osaka 599-8531, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Katayama
authors.affiliation: Nanoscience and Nanotechnology Research Center, Research Organization for the 21st Century, Osaka Prefecture University, 1-2, Gakuen-cho, Naka-ku, Osaka 599-8570, Japan. i-nakase@21c.osakafu-u.ac.jp and Graduate School of Science, Osaka Prefecture University, 1-1, Gakuen-cho, Naka-ku, Osaka 599-8531, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Noguchi
authors.affiliation: School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's University, 11-68, Koshien Kyuban-cho, Nishinomiya, Hyogo 663-8179, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Takatani-Nakase
authors.affiliation: Keio Advanced Research Centers (KARC), Keio University, 2, Okubo, Tsukuba, Ibaraki 300-2611, Japan and Institute for Advanced Sciences, Toagosei Co., Ltd, 2, Okubo, Tsukuba, Ibaraki 300-2611, Japan.
authors.forename: N B
authors.initials: NB
authors.lastname: Kobayashi
authors.affiliation: Keio Advanced Research Centers (KARC), Keio University, 2, Okubo, Tsukuba, Ibaraki 300-2611, Japan and Institute for Advanced Sciences, Toagosei Co., Ltd, 2, Okubo, Tsukuba, Ibaraki 300-2611, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Yoshida
authors.affiliation: Graduate School of Science, Osaka Prefecture University, 1-1, Gakuen-cho, Naka-ku, Osaka 599-8531, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Fujii
authors.affiliation: Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Futaki
mesh_terms: D000595:Amino Acid Sequence; D055354:Exosomes / Q000378:metabolism*; D006367:HeLa Cells; D006801:Humans; D010446:Peptide Fragments / Q000737:chemistry / Q000378:metabolism*; D021381:Protein Transport; D011956:Receptors, Cell Surface / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D010446:Peptide Fragments; D011956:Receptors, Cell Surface