title: Cost-effectiveness of a 23-valent pneumococcal polysaccharide vaccine immunization programme for the elderly in Shanghai, China.
abstract: To evaluate the cost-effectiveness of adding 23-valent pneumococcal polysaccharide vaccine (PPSV23) to the immunization schedule for the elderly population (age>60years) in Shanghai, China.
  
  
  
  A decision-tree model, with data and assumptions adapted from the societal perspective of Shanghai City, was developed to project the health outcomes of PPSV23 vaccination (compared with no vaccination) over a lifetime course. Sensitivity analysis was used to test the model's robustness. The clinical data, utility and treatment costs related to pneumococcal diseases were either cited from the literature or calculated from local sources.
  
  
  
  The incremental cost-effectiveness ratio of PPSV23 vaccination compared with no vaccination was $16,699/quality-adjusted life years gained, which was lower than the per capita GDP of Shanghai ($16,840). Sensitivity analyses showed that the model's outcome is robust.
  
  
  
  Routine vaccination of the elderly population with PPSV23 is cost-effective in Shanghai, China.
authors.affiliation: Hongkou CDC, Shanghai, China.
authors.forename: Daijun
authors.initials: D
authors.lastname: Zhao
authors.affiliation: Department of Health Policy, National Center for Child Health and Development, Tokyo, Japan.
authors.forename: Ruoyan
authors.initials: R
authors.lastname: Gai Tobe
authors.affiliation: Medical Decision and Economic Group, Department of Pharmacy, Ren Ji Hospital, South Campus, School of Medicine, Shanghai Jiaotong University, China.
authors.forename: Min
authors.initials: M
authors.lastname: Cui
authors.affiliation: Department of Otorhinolaryngology, Shanghai First People's Hospital, Affiliated with the School of Medicine, Shanghai Jiaotong University, China.
authors.forename: Jinchun
authors.initials: J
authors.lastname: He
authors.affiliation: Medical Decision and Economic Group, Department of Pharmacy, Ren Ji Hospital, South Campus, School of Medicine, Shanghai Jiaotong University, China. Electronic address: wbwithtg@hotmail.com.
authors.forename: Bin
authors.initials: B
authors.lastname: Wu
mesh_terms: D000368:Aged; D002681:China; D003362:Cost-Benefit Analysis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011008:Pneumococcal Infections / Q000191:economics* / Q000517:prevention & control*; D022242:Pneumococcal Vaccines / Q000008:administration & dosage / Q000191:economics*; D014611:Vaccination / Q000191:economics*
chemical_list: C414006:23-valent pneumococcal capsular polysaccharide vaccine; D022242:Pneumococcal Vaccines
keywords: Cost-effectiveness analysis; PPSV23; Pneumococcal disease; Vaccine