title: Comparison between submucosal tunneling endoscopic resection and endoscopic full-thickness resection for gastric stromal tumors originating from the muscularis propria layer.
abstract: Both submucosal tunneling endoscopic resection (STER) and endoscopic full-thickness resection (EFTR) are effective method for treating gastric gastrointestinal stromal tumors (GISTs); however, little is known about the comparison between STER and EFTR. The aim of the study was to compare the safety and efficacy of STER and EFTR for treating gastric GIST.
  
  
  
  We retrospectively collected the clinical data about patients with gastric GISTs who received STER or EFTR at our hospital from April 2011 to June 2016. Epidemiological data (gender, age), tumor size, procedure-related parameters, complications, length of stay, cost and follow-up data were compared between STER and EFTR.
  
  
  
  A total of 52 patients were enrolled, and 20 of them received STER, while the other 32 cases received EFTR. There was no significant difference between the two groups in terms of gender, age, concomitant diseases, tumor size, en bloc resection rate, operation time, complications, pathohistological grade of GIST, hospital stay and cost (P > 0.05). However, patients who received EFTR had a longer suture time and needed more clips to close the gastric-wall defect (STER vs EFTR, 291.5 ± 68.7 vs 380.6 ± 96.9s and 6.0 ± 1.2 vs 7.6 ± 1.6, P < 0.05). No recurrence was noted in the STER and EFTR groups during a mean follow-up of 10.9 and 23.8 months, respectively.
  
  
  
  The treatment efficacy between STER and EFTR for treating gastric GISTs was comparable, and a large-scale, randomized study is necessary for a more confirmed conclusion.
authors.affiliation: Department of Gastroenterology, The Second Xiangya Hospital of Central South University, NO.139 Middle Renmin Road, Changsha, 410011, Hunan, People's Republic of China.
authors.forename: Yuyong
authors.initials: Y
authors.lastname: Tan
authors.affiliation: Department of Gastroenterology, The Second Xiangya Hospital of Central South University, NO.139 Middle Renmin Road, Changsha, 410011, Hunan, People's Republic of China.
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Tang
authors.affiliation: Department of Gastroenterology, The Second Xiangya Hospital of Central South University, NO.139 Middle Renmin Road, Changsha, 410011, Hunan, People's Republic of China.
authors.forename: Ting
authors.initials: T
authors.lastname: Guo
authors.affiliation: Department of Gastroenterology, The Second Xiangya Hospital of Central South University, NO.139 Middle Renmin Road, Changsha, 410011, Hunan, People's Republic of China.
authors.forename: Dongzi
authors.initials: D
authors.lastname: Peng
authors.affiliation: Department of Gastroenterology, The Second Xiangya Hospital of Central South University, NO.139 Middle Renmin Road, Changsha, 410011, Hunan, People's Republic of China.
authors.forename: Yao
authors.initials: Y
authors.lastname: Tang
authors.affiliation: Department of Gastroenterology, The Second Xiangya Hospital of Central South University, NO.139 Middle Renmin Road, Changsha, 410011, Hunan, People's Republic of China.
authors.forename: Tianying
authors.initials: T
authors.lastname: Duan
authors.affiliation: Department of Gastroenterology, The Second Xiangya Hospital of Central South University, NO.139 Middle Renmin Road, Changsha, 410011, Hunan, People's Republic of China.
authors.forename: Xuehong
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Gastroenterology, The Second Xiangya Hospital of Central South University, NO.139 Middle Renmin Road, Changsha, 410011, Hunan, People's Republic of China.
authors.forename: Liang
authors.initials: L
authors.lastname: Lv
authors.affiliation: Department of Gastroenterology, The Second Xiangya Hospital of Central South University, NO.139 Middle Renmin Road, Changsha, 410011, Hunan, People's Republic of China.
authors.forename: Jirong
authors.initials: J
authors.lastname: Huo
authors.affiliation: Department of Gastroenterology, The Second Xiangya Hospital of Central South University, NO.139 Middle Renmin Road, Changsha, 410011, Hunan, People's Republic of China. liudeliang@medmail.com.cn.
authors.forename: Deliang
authors.initials: D
authors.lastname: Liu
mesh_terms: D000328:Adult; D000368:Aged; D002681:China; D005260:Female; D046152:Gastrointestinal Stromal Tumors / Q000601:surgery*; D005773:Gastroscopy / Q000379:methods*; D006801:Humans; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000601:surgery*; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000601:surgery*; D013525:Surgical Instruments; D016896:Treatment Outcome
keywords: Endoscopic full-thickness resection; Gastric submucosal tumor; Gastrointestinal stromal tumor; Submucosal tunneling endoscopic resection