title: RETINAL ANGIOMATOUS PROLIFERATION DIAGNOSIS: A Multiimaging Approach.
abstract: OBJECTIVE
  To identify signs occurring more frequently in retinal angiomatous proliferation (RAP) lesions compared with other types of choroidal neovascularization (CNV) in age-related macular degeneration.
  
  
  METHODS
  In this cross-sectional retrospective study, 30 patients were evaluated. These signs were correlated with the type of CNV: shunting of blood flow to the lesion by fluorescein angiography, late leakage by indocyanine green angiography, intraretinal cysts and retinal pigmented epithelium interruption along the retinal pigmented epithelium detachment with a hyperreflective oval area by spectral domain optical coherence tomography, and presence of reticular pseudodrusen by infrared light.
  
  
  RESULTS
  Shunting of blood flow was found in 56% of RAP, whereas it was absent in 100% of other CNVs. Late leakage in indocyanine green angiography occurred in all RAP cases, while it was found in 7% of other CNVs. Intraretinal cysts were detected in 100% of RAP cases and in 14% of other CNVs. Retinal pigmented epithelium interruption along the retinal pigmented epithelium detachment was evident in 93% of RAP cases and in 15% of other CNVs. Reticular pseudodrusen were present in 87% of RAP cases and in 21% of other CNVs.
  
  
  CONCLUSIONS
  All the signs investigated were strongly associated to RAP lesions. A multimodal imaging approach may help differentiating subtypes of neovascularization.
authors.affiliation: Eye Clinic, Department of Clinical Science "Luigi Sacco", Luigi Sacco Hospital, University of Milan, Milan, Italy.
authors.forename: Vittoria
authors.initials: V
authors.lastname: Ravera
authors.forename: Ferdinando
authors.initials: F
authors.lastname: Bottoni
authors.forename: Andrea
authors.initials: A
authors.lastname: Giani
authors.forename: Mario
authors.initials: M
authors.lastname: Cigada
authors.forename: Giovanni
authors.initials: G
authors.lastname: Staurenghi
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000798:Angiomatosis / Q000000981:diagnostic imaging*; D020256:Choroidal Neovascularization / Q000000981:diagnostic imaging*; D003430:Cross-Sectional Studies; D005260:Female; D005451:Fluorescein Angiography / Q000379:methods; D006801:Humans; D007208:Indocyanine Green; D008268:Macular Degeneration / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging; D012163:Retinal Detachment / Q000175:diagnosis; D015861:Retinal Neovascularization / Q000000981:diagnostic imaging*; D055213:Retinal Pigment Epithelium / Q000473:pathology; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence / Q000379:methods; D014792:Visual Acuity
chemical_list: D007208:Indocyanine Green