title: Tor-dependent post-transcriptional regulation of autophagy: Implications for cancer therapeutics.
abstract: Paradoxically, both anticancer immunosurveillance and tumor progression have been associated with intact autophagy, which is regulated by the target of rapamycin (Tor1). Here, we describe the potential impact on the design of cancer therapeutics of a newly described highly conserved post-transcriptional mechanism whereby Tor regulates autophagy.
authors.affiliation: Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD, USA.
authors.forename: Guowu
authors.initials: G
authors.lastname: Hu
authors.affiliation: Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD, USA.
authors.forename: Travis
authors.initials: T
authors.lastname: McQuiston
authors.affiliation: Life Sciences Institute, University of Michigan , Ann Arbor, MI, USA.
authors.forename: Amélie
authors.initials: A
authors.lastname: Bernard
authors.affiliation: Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD, USA.
authors.forename: Yoon-Dong
authors.initials: YD
authors.lastname: Park
authors.affiliation: Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD, USA.
authors.forename: Jin
authors.initials: J
authors.lastname: Qiu
authors.affiliation: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD, USA.
authors.forename: Ali
authors.initials: A
authors.lastname: Vural
authors.affiliation: Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD, USA.
authors.forename: Nannan
authors.initials: N
authors.lastname: Zhang
authors.affiliation: Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD, USA.
authors.forename: Scott R
authors.initials: SR
authors.lastname: Waterman
authors.affiliation: Intramural Research Program in Genomics of Differentiation, National Institute of Child Health and Human Development, National Institutes of Health , Bethesda , MD, USA.
authors.forename: Nathan H
authors.initials: NH
authors.lastname: Blewett
authors.affiliation: Genomic Technologies Section, Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health , MD, USA.
authors.forename: Timothy G
authors.initials: TG
authors.lastname: Myers
authors.affiliation: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD, USA.
authors.forename: John H
authors.initials: JH
authors.lastname: Kehrl
authors.affiliation: Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD, USA.
authors.forename: Gulbu
authors.initials: G
authors.lastname: Uzel
authors.affiliation: Life Sciences Institute, University of Michigan , Ann Arbor, MI, USA.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Klionsky
authors.affiliation: Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD, USA.
authors.forename: Peter R
authors.initials: PR
authors.lastname: Williamson
keywords: Autoimmunity; Tor; autophagy; oncology; pharmacology; phosphorylation; tumor immunology