title: Hospitalization for Anxiety and Mood Disorders in HIV-Infected and -Uninfected Gay and Bisexual Men.
abstract: BACKGROUND
  Prevalence of anxiety and mood disorders (AMDs) in HIV-infected individuals has varied widely because of the variety of measurements used and differences in risk factor profiles between different populations. We aimed to examine the relationship between HIV status and hospitalization for AMDs in gay and bisexual men (GBM).
  
  
  METHODS
  HIV-infected (n = 557) and HIV-uninfected (n = 1325) GBM recruited in Sydney, Australia were probabilistically linked to their hospital admissions and death notifications (2000-2012). Random-effects Poisson models were used to assess HIV risk factors for hospitalization. Cox regression methods were used to assess risk factors for mortality.
  
  
  RESULTS
  We observed 300 hospitalizations for AMDs in 15.3% of HIV-infected and 181 in 5.4% of HIV-uninfected participants. Being infected with HIV was associated with a 2.5-fold increase in risk of hospitalization for AMDs in GBM. Other risk factors in the HIV-infected cohort included previous hospitalization for HIV-related dementia, a more recent HIV diagnosis, and a CD4 T-cell count above 350 cells per cubic millimeter. Being hospitalized for an AMD was associated with a 5.5-fold increased risk of mortality; this association did not differ by HIV status. An association between substance use and mortality was observed in individuals hospitalized for AMDs.
  
  
  CONCLUSIONS
  There is a need to provide more effective strategies to identify and treat AMDs in HIV-infected GBM. This research highlights the importance of further examination of the effects of substance use, neurocognitive decline, and AMDs on the health of HIV-infected individuals.
authors.affiliation: *The Kirby Institute, University of New South Wales, Sydney, New South Wales, Australia; †Australian Research Centre in Sex, Health and Society, La Trobe University, Melbourne, Victoria, Australia; ‡School of Public Health and Community Medicine, University of New South Wales, Sydney, New South Wales, Australia; and §Centre for Social Research in Health, University of New South Wales, Sydney, New South Wales, Australia.
authors.forename: Cecilia L
authors.initials: CL
authors.lastname: Moore
authors.forename: Andrew E
authors.initials: AE
authors.lastname: Grulich
authors.forename: Garrett
authors.initials: G
authors.lastname: Prestage
authors.forename: Heather F
authors.initials: HF
authors.lastname: Gidding
authors.forename: Fengyi
authors.initials: F
authors.lastname: Jin
authors.forename: Kathy
authors.initials: K
authors.lastname: Petoumenos
authors.forename: Iryna B
authors.initials: IB
authors.lastname: Zablotska
authors.forename: I Mary
authors.initials: IM
authors.lastname: Poynten
authors.forename: Limin
authors.initials: L
authors.lastname: Mao
authors.forename: Matthew G
authors.initials: MG
authors.lastname: Law
authors.forename: Janaki
authors.initials: J
authors.lastname: Amin
mesh_terms: D000328:Adult; D001007:Anxiety / Q000150:complications / Q000453:epidemiology*; D001315:Australia / Q000453:epidemiology; D015331:Cohort Studies; D015658:HIV Infections / Q000150:complications* / Q000523:psychology; D006760:Hospitalization; D006801:Humans; D008297:Male; D008875:Middle Aged; D019964:Mood Disorders / Q000150:complications / Q000453:epidemiology*; D015995:Prevalence; D000072339:Sexual and Gender Minorities; D016019:Survival Analysis