title: Wnt Signaling as Master Regulator of T-Lymphocyte Responses: Implications for Transplant Therapy.
abstract: T cell-mediated immune responses to the grafted tissues are the major reason for failed organ transplantation. The regulation of T cell responses is complex and involves major histocompatibility complex molecules on transplanted organs, cytokines, regulatory cells, and antigen-presenting cells. The evolutionary conserved Wnt signal transduction pathway has long been known for its importance in development of stem cells and immature T cells in the thymus. Recent evidence indicates the Wnt pathway as a master regulator of T cell immune responses via governing the balance between T helper 17/regulatory T cells and by regulating the formation of effector and memory cytotoxic CD8 T cell responses. In doing so, Wnt signals influence the outcome of immune responses in transplantation settings.
authors.affiliation: 1 Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands.
authors.forename: Frank J T
authors.initials: FJ
authors.lastname: Staal
authors.forename: Ramon
authors.initials: R
authors.lastname: Arens
mesh_terms: D000818:Animals; D000938:Antigen-Presenting Cells / Q000166:cytology; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology; D003713:Dendritic Cells / Q000166:cytology; D006410:Hematopoiesis; D006801:Humans; D038041:Lymphopoiesis; D008285:Major Histocompatibility Complex / Q000276:immunology; D051379:Mice; D016377:Organ Transplantation; D013234:Stem Cells / Q000166:cytology; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology*; D013950:Thymus Gland / Q000276:immunology; D051153:Wnt Proteins / Q000378:metabolism*; D060449:Wnt Signaling Pathway
chemical_list: D051153:Wnt Proteins