title: Nitric oxide and hyperoxic acute lung injury.
abstract: Hyperoxic acute lung injury (HALI) refers to the damage to the lungs secondary to exposure to elevated oxygen partial pressure. HALI has been a concern in clinical practice with the development of deep diving and the use of normobaric as well as hyperbaric oxygen in clinical practice. Although the pathogenesis of HALI has been extensively studied, the findings are still controversial. Nitric oxide (NO) is an intercellular messenger and has been considered as a signaling molecule involved in many physiological and pathological processes. Although the role of NO in the occurrence and development of pulmonary diseases including HALI has been extensively studied, the findings on the role of NO in HALI are conflicting. Moreover, inhalation of NO has been approved as a therapeutic strategy for several diseases. In this paper, we briefly summarize the role of NO in the pathogenesis of HALI and the therapeutic potential of inhaled NO in HALI.
authors.affiliation: Department of Diving and Hyperbaric Medicine, Secondary Military Medical University, Shanghai, China.
authors.forename: Wen-Wu
authors.initials: WW
authors.lastname: Liu
authors.affiliation: Department of Pathology, the First Hospital of Jining City, Jining, Shandong Province, China.
authors.forename: Cui-Hong
authors.initials: CH
authors.lastname: Han
authors.affiliation: Department of Cardiothoracic Surgery, the First Hospital of Jining City, Jining, Shandong Province, China.
authors.forename: Pei-Xi
authors.initials: PX
authors.lastname: Zhang
authors.affiliation: Department of Diving and Hyperbaric Medicine, Secondary Military Medical University, Shanghai, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Zheng
authors.affiliation: Department of Diving and Hyperbaric Medicine, Secondary Military Medical University, Shanghai, China.
authors.forename: Kan
authors.initials: K
authors.lastname: Liu
authors.affiliation: Department of Diving and Hyperbaric Medicine, Secondary Military Medical University, Shanghai, China.
authors.forename: Xue-Jun
authors.identifier: 0000-0003-2387-5531
authors.initials: XJ
authors.lastname: Sun
keywords: hyperoxia; hyperoxic acute lung injury; inhaled nitric oxide; nitric oxide; nitric oxide synthase; nitro-L-arginine methyl ester; reactive nitrogen species; reactive oxygen species