title: HSP70: therapeutic potential in acute and chronic cardiac disease settings.
abstract: Heat shock proteins are a family of proteins that are produced by cells in response to exposure to stressful conditions. The best studied heat shock protein is HSP70, which is known to act as a molecular chaperone to maintain cellular homeostasis and inhibit protein aggregation in response to stress. While early animal studies suggested that increasing HSP70 in the heart (using a transgenic, gene transfer or pharmacological approach) provided cardiac protection against acute cardiac stress, recent studies have found no benefit of increasing HSP70 in mouse models of chronic cardiac stress. As HSP70 has been considered a potential therapeutic target, it is important to comprehensively assess HSP70 therapies in preclinical models of acute and chronic cardiac disease.
authors.affiliation: Baker IDI Heart & Diabetes Institute, Melbourne, 3004, Australia.
authors.forename: Bianca C
authors.initials: BC
authors.lastname: Bernardo
authors.affiliation: Baker IDI Heart & Diabetes Institute, Melbourne, 3004, Australia.
authors.forename: Kate L
authors.initials: KL
authors.lastname: Weeks
authors.affiliation: Baker IDI Heart & Diabetes Institute, Melbourne, 3004, Australia.
authors.forename: Natalie L
authors.initials: NL
authors.lastname: Patterson
authors.affiliation: Baker IDI Heart & Diabetes Institute, Melbourne, 3004, Australia.|Department of Physiology and Department of Medicine, Monash University, Clayton, Victoria 3800, Australia.
authors.forename: Julie R
authors.initials: JR
authors.lastname: McMullen
mesh_terms: D000208:Acute Disease; D000818:Animals; D002908:Chronic Disease; D018840:HSP70 Heat-Shock Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D006331:Heart Diseases / Q000188:drug therapy* / Q000378:metabolism*; D006801:Humans; D051379:Mice
chemical_list: D018840:HSP70 Heat-Shock Proteins
keywords: HSP70; heart; heart failure; heat shock proteins; stress; therapy