title: A CoIIcomplex for19F MRI-based detection of reactive oxygen species.
abstract: A fluorinated, air-stable cobalt(ii) complex serves as a turn-on19F magnetic resonance imaging (MRI) tracer for reactive oxygen species including H2O2. Upon oxidation with H2O2, the complex converts from paramagnetic high spin CoIIto diamagnetic low spin CoIIIresulting in a chemical shift change and enhancement in19F NMR signal. Further, the oxidation can be reversed in the presence of reductant Na2S2O4. The turn-on response is demonstrated by19F MRI, characterized by a ∼2-3 fold enhancement in signal.
authors.affiliation: Department of Chemistry, The University of Texas at Austin, 105 E. 24th St. Stop A5300, Austin, TX 78712, USA. emilyque@cm.utexas.edu.
authors.forename: Meng
authors.initials: M
authors.lastname: Yu
authors.forename: Da
authors.initials: D
authors.lastname: Xie
authors.forename: Khanh P
authors.initials: KP
authors.lastname: Phan
authors.forename: José S
authors.initials: JS
authors.lastname: Enriquez
authors.forename: Jeffrey J
authors.initials: JJ
authors.lastname: Luci
authors.forename: Emily L
authors.initials: EL
authors.lastname: Que
mesh_terms: D003035:Cobalt / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000737:chemistry*; D005462:Fluorine Radioisotopes; D008279:Magnetic Resonance Imaging; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D017382:Reactive Oxygen Species / Q000032:analysis*
chemical_list: D005456:Fluorescent Dyes; D005462:Fluorine Radioisotopes; D009942:Organometallic Compounds; D017382:Reactive Oxygen Species; D003035:Cobalt