title: Metabolic changes during B cell differentiation for the production of intestinal IgA antibody.
abstract: To sustain the bio-energetic demands of growth, proliferation, and effector functions, the metabolism of immune cells changes dramatically in response to immunologic stimuli. In this review, I focus on B cell metabolism, especially regarding the production of intestinal IgA antibody. Accumulating evidence has implicated not only host-derived factors (e.g., cytokines) but also gut environmental factors, including the possible involvement of commensal bacteria and diet, in the control of B cell metabolism during intestinal IgA antibody production. These findings yield new insights into the regulation of immunosurveillance and homeostasis in the gut.
authors.affiliation: Laboratory of Vaccine Materials, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), 7-6-8 Saito-Asagi, Ibaraki, Osaka, 567-0085, Japan. kunisawa@nibiohn.go.jp.|Division of Mucosal Immunology, Department of Microbiology and Immunology and International Research and Development Center for Mucosal Vaccines, The Institute of Medical Science, The University of Tokyo, Tokyo, 108-8639, Japan. kunisawa@nibiohn.go.jp.|Graduate School of Medicine, Graduate School of Pharmaceutical Sciences, Graduate School of Dentistry, Osaka University, Osaka, 565-0871, Japan. kunisawa@nibiohn.go.jp.|Department of Microbiology and Infectious Diseases, Kobe University Graduate School of Medicine, Kobe, 650-0017, Japan. kunisawa@nibiohn.go.jp.
authors.forename: Jun
authors.initials: J
authors.lastname: Kunisawa
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology* / Q000378:metabolism; D002454:Cell Differentiation; D004734:Energy Metabolism; D006801:Humans; D007111:Immunity, Cellular; D007070:Immunoglobulin A / Q000276:immunology* / Q000378:metabolism; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000276:immunology* / Q000382:microbiology*; D010581:Peyer's Patches / Q000276:immunology / Q000378:metabolism / Q000382:microbiology; D013831:Thiamine / Q000276:immunology / Q000378:metabolism
chemical_list: D007070:Immunoglobulin A; D013831:Thiamine
keywords: B cell; Commensal bacteria; Glycolysis; IgA antibody; Immunometabolism; Lipid; Mucosal vaccine; Signaling; TCA cycle; Vitamin B1