title: Use of Prothrombin Complex Concentrate for Warfarin Reversal Before the Performance of an Epidural Blood Patch in a Patient With Cortical Vein Thrombosis and Subdural Hematoma: A Case Report.
abstract: Compared to conventional therapy, several studies with prothrombin complex concentrate (PCC) have recently demonstrated its superior efficacy in rapidly replacing vitamin K-dependent factors for patients with life-threatening hemorrhage. We present a novel use of PCC in a patient with intracranial hypotension, who had received warfarin for treatment of cortical vein thrombosis. However, after anticoagulation, she proceeded to develop bilateral subdural hematomas with descent of cerebellar tonsils. Given the possibility of an occult dural puncture during labor analgesia, an epidural blood patch was performed after administration of PCC and normalization of coagulation parameters, with prompt improvement of the patient's headache.
authors.affiliation: From the *Department of Anesthesiology, Texas Tech University Health Sciences Center, Lubbock, Texas; and †UT Southwestern Department of Anesthesiology and Pain Management, Dallas, Texas.
authors.forename: Kallol
authors.initials: K
authors.lastname: Chaudhuri
authors.forename: Cooper W
authors.initials: CW
authors.lastname: Phillips
authors.forename: Swapna
authors.initials: S
authors.lastname: Chaudhuri
authors.forename: John
authors.initials: J
authors.lastname: Wasnick
mesh_terms: D001779:Blood Coagulation Factors / Q000008:administration & dosage*; D017217:Blood Patch, Epidural / Q000379:methods*; D005260:Female; D006408:Hematoma, Subdural / Q000188:drug therapy* / Q000209:etiology; D006490:Hemostatics; D006801:Humans; D020767:Intracranial Thrombosis / Q000188:drug therapy* / Q000209:etiology; D016896:Treatment Outcome; D014859:Warfarin / Q000009:adverse effects; D055815:Young Adult
chemical_list: D001779:Blood Coagulation Factors; D006490:Hemostatics; C025667:prothrombin complex concentrates; D014859:Warfarin