title: Increased lysyl oxidase-like 2 associates with a poor prognosis in non-small cell lung cancer.
abstract: BACKGROUND
  Lysyl oxidase-like 2 (LOXL2) is a member of the lysyl oxidase family and is associated with invasiveness and metastasis in breast cancer. However, its relevance in non-small cell lung cancer (NSCLC) remained largely unknown.
  
  
  METHODS
  LOXL2 protein levels in a cohort of NSCLC and adjacent normal lung tissues were evaluated and analyzed their clinicopathologic and prognostic significance.
  
  
  RESULTS
  It was found that cytoplasmic and nuclear LOXL2 levels were higher in lung adenocarcinoma (AD) and squamous cell carcinoma (SCC) tissues than in paired adjacent normal tissues. High LOXL2 levels were associated with p-TNM stage, and cytoplasmic, but not nuclear, LOXL2 levels were an independent prognostic factor in lung AD and SCC patients.
  
  
  CONCLUSIONS
  These results demonstrate that elevated LOXL2 levels are positively associated with poor prognosis in NSCLC patients. LOXL2 might, therefore, serve as a novel prognostic biomarker and potential therapeutic target in NSCLC patients.
authors.affiliation: Department of Respiratory Medicine, Nanjing Chest Hospital, Medical School of Southeast University, Nanjing, 210029, China.|Clinical Center of Nanjing Respiratory Diseases and Imaging, Nanjing, 210029, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Zhan
authors.affiliation: Department of Respiratory Medicine, Affiliated Jiangsu Province Hospital of Traditional Chinese Medicine, Nanjing University of Traditional Chinese Medicine, Nanjing, 210029, China.
authors.forename: Xiao-Jing
authors.initials: XJ
authors.lastname: Lv
authors.affiliation: Affiliated Jiangsu Province Hospital of Traditional Chinese Medicine, Nanjing University of Traditional Chinese Medicine, Nanjing, 210029, China.
authors.forename: Ya-Nan
authors.initials: YN
authors.lastname: Ji
authors.affiliation: Department of Respiratory Medicine, Nanjing Chest Hospital, Medical School of Southeast University, Nanjing, 210029, China.|Clinical Center of Nanjing Respiratory Diseases and Imaging, Nanjing, 210029, China.
authors.forename: Haiyan
authors.initials: H
authors.lastname: Xie
authors.affiliation: Department of Respiratory Medicine, Nanjing Chest Hospital, Medical School of Southeast University, Nanjing, 210029, China.|Clinical Center of Nanjing Respiratory Diseases and Imaging, Nanjing, 210029, China.
authors.forename: Li-Ke
authors.initials: LK
authors.lastname: Yu
mesh_terms: D000328:Adult; D000368:Aged; D000594:Amino Acid Oxidoreductases / Q000235:genetics*; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics* / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D016022:Case-Control Studies; D018572:Disease-Free Survival; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D053208:Kaplan-Meier Estimate; D008175:Lung Neoplasms / Q000235:genetics* / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D011013:Pneumonectomy / Q000379:methods / Q000401:mortality; D011379:Prognosis; D018570:Risk Assessment; D018709:Statistics, Nonparametric; D016019:Survival Analysis; D016896:Treatment Outcome; D015854:Up-Regulation
chemical_list: D000594:Amino Acid Oxidoreductases; C119091:LOXL2 protein, human
keywords: lysyl oxidase-like 2; metastasis; non-small cell lung cancer; prognosis