title: Spatial Ca2+profiling: decrypting the universal cytosolic Ca2+oscillation.
abstract: Stimulation of cell-surface receptors that couple to phospholipase C to generate the second messenger inositol trisphosphate often evokes repetitive oscillations in cytosolic Ca2+. Signalling information is encoded in both the amplitude and frequency of the Ca2+spikes. Recent studies have revealed that the spatial profile of the oscillation also imparts signalling power; Ca2+microdomains near store-operated CRAC channels in the plasma membrane and inositol trisphosphate-gated channels in the endoplasmic reticulum both signal to distinct downstream targets. Spatial profiling therefore increases the transduction power of the universal oscillatory cytosolic Ca2+signal.
authors.affiliation: Department of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, Oxford, OX1 3PT, UK.
authors.forename: Krishna
authors.initials: K
authors.lastname: Samanta
authors.affiliation: Department of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, Oxford, OX1 3PT, UK.
authors.forename: Anant B
authors.identifier: 0000-0002-4860-1644
authors.initials: AB
authors.lastname: Parekh
mesh_terms: D000818:Animals; D002118:Calcium / Q000502:physiology*; D000071739:Calcium Release Activated Calcium Channels / Q000502:physiology; D020013:Calcium Signaling; D003600:Cytosol / Q000502:physiology*; D004721:Endoplasmic Reticulum / Q000502:physiology; D006801:Humans; D008928:Mitochondria / Q000502:physiology
chemical_list: D000071739:Calcium Release Activated Calcium Channels; D002118:Calcium
keywords: calcium channel; cytosolic calcium; mitochondria