title: Vestibular cerebellum of thick-toed geckos (Chondrodactylus turnery GRAY, 1864) and C57/BL6N mice after the long-term space flight on the biosatellite BION-M1.
abstract: The aim of this study was to estimate the effects of long-term space flights on neuronal and glial cells of the vestibular cerebellum of C57/BL6N mice and thick-toed geckos (Chondrodactylus turnery GRAY, 1864). The cerebella from 26 mice and 13 geckos were used in this study. Ten mice and five geckos were flown aboard the BION-M1 biosatellite. The other animals were used as controls. We used immunohistochemical techniques and classical histological method to reveal cell types in the vestibular cerebellum. Nonspecific pathomorphological changes in the Purkinje cells (such as chromatolysis, vacuolization and hyperchromatosis) were observed in the flight groups. However, these changes are reversible and were also found in some neurons in the control groups. In addition, as the vestibular cerebellum is an evolutionarily stable structure, thick-toed geckos may be a useful model for space flight studies on the vertebrate cerebellum.
authors.affiliation: FSBSI Science Research Institute of Human Morphology, Moscow, Russia. Electronic address: proschina@mtu-net.ru.
authors.forename: Proshchina
authors.initials: P
authors.lastname: Alexandra
authors.affiliation: FSBSI Science Research Institute of Human Morphology, Moscow, Russia.
authors.forename: Kharlamova
authors.initials: K
authors.lastname: Anastasia
authors.affiliation: FSBSI Science Research Institute of Human Morphology, Moscow, Russia.
authors.forename: Barabanov
authors.initials: B
authors.lastname: Valeriy
authors.affiliation: FSBSI Science Research Institute of Human Morphology, Moscow, Russia.
authors.forename: Gulimova
authors.initials: G
authors.lastname: Victoria
authors.affiliation: FSBSI Science Research Institute of Human Morphology, Moscow, Russia.
authors.forename: Saveliev
authors.initials: S
authors.lastname: Sergey
mesh_terms: D000818:Animals; D002452:Cell Count / Q000379:methods; D002531:Cerebellum / Q000737:chemistry* / Q000166:cytology* / Q000473:pathology; D008116:Lizards; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D013026:Space Flight / Q000379:methods / Q000639:trends*; D018531:Spacecraft; D013997:Time Factors
keywords: Bergmann glia; Cerebellum; Mice; Purkinje cells; Space flight; Thick-toed geckos