title: A hierarchical polymer brush coating with dual-function antibacterial capability.
abstract: Bacterial infections are problematic in many healthcare-associated devices. Antibacterial surfaces integrating the strength of bacteria repellent and bactericidal functions exhibit an encouraging efficacy in tackling this problem. Herein, a hierarchical dual-function antibacterial polymer brush coating that integrates an antifouling bottom layer with a bactericidal top layer is facilely constructed via living photograft polymerization. Excellent resistance to bacterial attachment is correlated with the antifouling components, and good bactericidal activity is afforded by the bactericidal components, and therefore the hierarchical coating shows an excellent long-term antibacterial capability. In addition, due to the presence of the hydrophilic background layer, the hierarchical surface has the greatly improved biocompatibility, as shown by the suppression of platelet adhesion and activation, the inhibition of erythrocyte adhesion and damage, and low toxicity against mammalian cells. The hierarchical polymer brush system provides the basis for the development of long-term antibacterial and biocompatible surfaces.
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, People's Republic of China; University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China.
authors.forename: Shunjie
authors.initials: S
authors.lastname: Yan
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, People's Republic of China.
authors.forename: Lingjie
authors.initials: L
authors.lastname: Song
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, People's Republic of China. Electronic address: sfluan@ciac.ac.cn.
authors.forename: Shifang
authors.initials: S
authors.lastname: Luan
authors.affiliation: Department of Polymer, School of Chemistry and Chemical Engineering, Yantai University, Yantai 264005, People's Republic of China.
authors.forename: Zhirong
authors.initials: Z
authors.lastname: Xin
authors.affiliation: Department of Polymer, School of Chemistry and Chemical Engineering, Yantai University, Yantai 264005, People's Republic of China.
authors.forename: Shanshan
authors.initials: S
authors.lastname: Du
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, People's Republic of China. Electronic address: shihc@ciac.ac.cn.
authors.forename: Hengchong
authors.initials: H
authors.lastname: Shi
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, People's Republic of China.
authors.forename: Shuaishuai
authors.initials: S
authors.lastname: Yuan
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, People's Republic of China.
authors.forename: Yuming
authors.initials: Y
authors.lastname: Yang
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, People's Republic of China.
authors.forename: Jinghua
authors.initials: J
authors.lastname: Yin
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry*; D001422:Bacterial Adhesion / Q000187:drug effects; D001424:Bacterial Infections / Q000188:drug therapy*; D001672:Biocompatible Materials / Q000737:chemistry; D018441:Biofilms; D002448:Cell Adhesion; D002460:Cell Line; D020099:Coated Materials, Biocompatible; D004912:Erythrocytes / Q000166:cytology; D004926:Escherichia coli / Q000187:drug effects; D051379:Mice; D010973:Platelet Adhesiveness; D011092:Polyethylene Glycols / Q000737:chemistry; D058105:Polymerization; D011108:Polymers / Q000737:chemistry*; D011817:Rabbits; D013211:Staphylococcus aureus / Q000187:drug effects; D013499:Surface Properties
chemical_list: D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D020099:Coated Materials, Biocompatible; D011108:Polymers; D011092:Polyethylene Glycols
keywords: Cytotoxicity; Dual-function antibacterial; Hierarchical polymer brush; Long-term antibacterial; Surface-initiated photoiniferter-mediated polymerization