title: Correlation of FDG-PET hypometabolism and SEEG epileptogenicity mapping in patients with drug-resistant focal epilepsy.
abstract: Interictal [18F]fluorodeoxyglucose-positron emission tomography (FDG-PET) is used in the presurgical evaluation of patients with drug-resistant focal epilepsy. We aimed at clarifying its relationships with ictal high-frequency oscillations (iHFOs) shown to be a relevant marker of the seizure-onset zone.
  
  
  
  We studied the correlation between FDG-PET and epileptogenicity maps in an unselected series of 37 successive patients having been explored with stereo-electroencephalography (SEEG).
  
  
  
  At the group level, we found a significant correlation between iHFOs and FDG-PET interictal hypometabolism only in cases of temporal lobe epilepsy. This correlation was found with HFOs, and the same comparison between FDG-PET and ictal SEEG power of lower frequencies during the same epochs did not show the same significance.
  
  
  
  This finding suggests that interictal FDG-PET and ictal HFOs may share common underlying pathophysiologic mechanisms of ictogenesis in temporal lobe epilepsy, and combining both features may help to identify the seizure-onset zone.
authors.affiliation: Univ. Grenoble Alpes, Grenoble Institute of Neuroscience, GIN, Grenoble, France.|Inserm, U1216, Grenoble, France.
authors.forename: Florence
authors.initials: F
authors.lastname: Lamarche
authors.affiliation: Univ. Grenoble Alpes, Grenoble Institute of Neuroscience, GIN, Grenoble, France.|Inserm, U1216, Grenoble, France.|CHU Grenoble Alpes, Neurology Department, Grenoble, France.
authors.forename: Anne-Sophie
authors.initials: AS
authors.lastname: Job
authors.affiliation: Univ. Grenoble Alpes, Grenoble Institute of Neuroscience, GIN, Grenoble, France.|Inserm, U1216, Grenoble, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Deman
authors.affiliation: Univ. Grenoble Alpes, Grenoble Institute of Neuroscience, GIN, Grenoble, France.|Inserm, U1216, Grenoble, France.
authors.forename: Manik
authors.initials: M
authors.lastname: Bhattacharjee
authors.affiliation: CHU Grenoble Alpes, Neurosurgery Department, Grenoble, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Hoffmann
authors.affiliation: CHU Grenoble Alpes, Nuclear Medicine Department, Grenoble, France.
authors.forename: Céline
authors.initials: C
authors.lastname: Gallazzini-Crépin
authors.affiliation: CERMEP, Lyon, France.
authors.forename: Sandrine
authors.initials: S
authors.lastname: Bouvard
authors.affiliation: Univ. Grenoble Alpes, Grenoble Institute of Neuroscience, GIN, Grenoble, France.|Inserm, U1216, Grenoble, France.|CHU Grenoble Alpes, Neurology Department, Grenoble, France.
authors.forename: Lorella
authors.initials: L
authors.lastname: Minotti
authors.affiliation: Univ. Grenoble Alpes, Grenoble Institute of Neuroscience, GIN, Grenoble, France.|Inserm, U1216, Grenoble, France.|CHU Grenoble Alpes, Neurology Department, Grenoble, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Kahane
authors.affiliation: Univ. Grenoble Alpes, Grenoble Institute of Neuroscience, GIN, Grenoble, France.|Inserm, U1216, Grenoble, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: David
mesh_terms: D000293:Adolescent; D000328:Adult; D001931:Brain Mapping; D002648:Child; D004567:Electrodes, Implanted; D004569:Electroencephalography; D004828:Epilepsies, Partial / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000378:metabolism*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D013223:Statistics as Topic; D055815:Young Adult
chemical_list: D019788:Fluorodeoxyglucose F18
keywords: 
  SEEG
  ; Epileptogenicity map; FDG-PET; Focal epilepsy; Ictal HFO