title: Drug-target interaction kinetics: underutilized in drug optimization?
authors.affiliation: Research & Development, Epizyme, Inc., 400 Technology Square, Cambridge, MA 02139, USA.
authors.forename: Robert A
authors.initials: RA
authors.lastname: Copeland
mesh_terms: D000818:Animals; D055808:Drug Discovery / Q000379:methods*; D006801:Humans; D007700:Kinetics; D008954:Models, Biological; D058990:Molecular Targeted Therapy; D010599:Pharmacokinetics; D000069437:Pharmacological Phenomena
keywords: drug–target residence time; kinetics; lead optimization; pharmacodynamics; pharmacokinetic–pharmacodynamics relationship