title: Reactions of aquacobalamin and cob(II)alamin with chlorite and chlorine dioxide.
abstract: Reactions of aquacobalamin (H2O-Cbl(III)) and its one-electron reduced form (cob(II)alamin, Cbl(II)) with chlorite (ClO2-) and chlorine dioxide (ClO2•) were studied by conventional and stopped-flow UV-Vis spectroscopies and matrix-assisted laser desorption/ionization-mass spectrometry (MALDI-MS). ClO2-does not react with H2O-Cbl(III), but oxidizes Cbl(II) to H2O-Cbl(III) as a major product and corrin-modified species as minor products. The proposed mechanism of chlorite reduction involves formation of OCl-that modifies the corrin ring during the course of reaction with Cbl(II). H2O-Cbl(III) undergoes relatively slow destruction by ClO2•via transient formation of oxygenated species, whereas reaction between Cbl(II) and ClO2•proceeds extremely rapidly and leads to the oxidation of the Co(II)-center.
authors.affiliation: Institute of Macroheterocyclic Compounds, Ivanovo State University of Chemistry and Technology, Sheremetevskiy Str. 7, 153000, Ivanovo, Russian Federation. derevenkov@gmail.com.
authors.forename: Ilia A
authors.initials: IA
authors.lastname: Dereven'kov
authors.affiliation: Institute of Macroheterocyclic Compounds, Ivanovo State University of Chemistry and Technology, Sheremetevskiy Str. 7, 153000, Ivanovo, Russian Federation.
authors.forename: Nikita I
authors.initials: NI
authors.lastname: Shpagilev
authors.affiliation: Department of Inorganic Chemistry, University of Pécs, Ifjúság útja 6, 7624, Pécs, Hungary.
authors.forename: László
authors.initials: L
authors.lastname: Valkai
authors.affiliation: Institute of Macroheterocyclic Compounds, Ivanovo State University of Chemistry and Technology, Sheremetevskiy Str. 7, 153000, Ivanovo, Russian Federation.
authors.forename: Denis S
authors.initials: DS
authors.lastname: Salnikov
authors.affiliation: Department of Inorganic Chemistry, University of Pécs, Ifjúság útja 6, 7624, Pécs, Hungary.|János Szentágothai Research Center, Ifjúság útja 34, 7624, Pécs, Hungary.
authors.forename: Attila K
authors.initials: AK
authors.lastname: Horváth
authors.affiliation: Institute of Macroheterocyclic Compounds, Ivanovo State University of Chemistry and Technology, Sheremetevskiy Str. 7, 153000, Ivanovo, Russian Federation.
authors.forename: Sergei V
authors.initials: SV
authors.lastname: Makarov
mesh_terms: D002712:Chlorides / Q000737:chemistry*; D017606:Chlorine Compounds / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D008968:Molecular Conformation; D010087:Oxides / Q000737:chemistry*; D014805:Vitamin B 12 / Q000031:analogs & derivatives* / Q000737:chemistry
chemical_list: D002712:Chlorides; D017606:Chlorine Compounds; D010087:Oxides; C043960:aquacobalamin; C097751:cob(II)alamin; C025109:chlorine dioxide; D014805:Vitamin B 12; C001599:chlorite
keywords: Chlorine dioxide; Chlorite; Kinetics; Redox reactions; Vitamin B12