title: Fine tuning through valence bond tautomerization of ancillary ligands in ruthenium(ii) arene complexes for better anticancer activity and enzyme inhibition properties.
abstract: Four new ruthenium arene PTA type complexes have been synthesized using substituted picolinamide derivatives as ancillary ligands and characterized by spectroscopic methods. In one of the complexes, the ancillary ligand has shown an unprecedented valence-bond tautomerization in the presence of an ammonium salt to act as a polar neutral donor ligand making the ligand more prone towards substitution. The same compound has shown remarkable antiproliferative activity against three cancer cell lines with GI50values comparable to Adriamycin, a known therapeutic drug. Along with this it also strongly inhibits the action of thioredoxin reductase, which might be a probable reason for the enhanced proliferative action of the valence-bond tautomerized compound.
authors.affiliation: Department of Chemistry, School of Basic Sciences, Indian Institute of Technology Indore, Indore 453552, India. suman@iiti.ac.in.
authors.forename: Poulami
authors.initials: P
authors.lastname: Mandal
authors.affiliation: Department of Chemistry, School of Basic Sciences, Indian Institute of Technology Indore, Indore 453552, India. suman@iiti.ac.in.
authors.forename: Novina
authors.initials: N
authors.lastname: Malviya
authors.affiliation: Centro de Química Estrutural, Complexo I, Instituto Superior Técnico, Technical University of Lisbon, Avenida Rovisco Pais, 1049-001, Lisbon, Portugal.
authors.forename: M Fátima C
authors.identifier: http://orcid.org/0000-0003-4836-2409
authors.initials: MF
authors.lastname: Guedes da Silva
authors.affiliation: Department of Chemistry, Indian Institute of Technology Ropar, Rupnagar 140001, Punjab, India.
authors.forename: Sandeep Singh
authors.initials: SS
authors.lastname: Dhankhar
authors.affiliation: Department of Chemistry, Indian Institute of Technology Ropar, Rupnagar 140001, Punjab, India.
authors.forename: C M
authors.initials: CM
authors.lastname: Nagaraja
authors.affiliation: Department of Chemistry, School of Basic Sciences, Indian Institute of Technology Indore, Indore 453552, India. suman@iiti.ac.in and Centre for Bioscience and Biomedical Engineering (BSBE), Indian Institute of Technology Indore, Indore 453552, India.
authors.forename: Shaikh M
authors.initials: SM
authors.lastname: Mobin
authors.affiliation: Department of Chemistry, School of Basic Sciences, Indian Institute of Technology Indore, Indore 453552, India. suman@iiti.ac.in and Centre for Bioscience and Biomedical Engineering (BSBE), Indian Institute of Technology Indore, Indore 453552, India.
authors.forename: Suman
authors.initials: S
authors.lastname: Mukhopadhyay
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D056831:Coordination Complexes / Q000737:chemistry / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D007536:Isomerism; D008024:Ligands; D066244:Proton Magnetic Resonance Spectroscopy; D012428:Ruthenium / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D000970:Antineoplastic Agents; D056831:Coordination Complexes; D004791:Enzyme Inhibitors; D008024:Ligands; D012428:Ruthenium