title: Soluble vascular cell adhesion molecular-1 is a potential biological indicator of hemophilic arthropathy.
abstract: Hemophilic arthropathy is the most common chronic complication in patients with hemophilia. The pathogenesis of hemophilic arthropathy involves the inflammatory processes associated with rheumatoid arthritis (RA). Determining the severity and/or progression of joint damage is crucial when evaluating the effect of treatment modalities. Identifying reliable biomarkers in the peripheral blood of patients with hemophilic arthropathy may be beneficial in clinical practice. Circulating soluble vascular cell adhesion molecule-1 (sVCAM-1), E-selectin, and P-selectin levels are elevated in patients with RA. Our study investigated whether these soluble adhesion molecules can be used as biological indicators in the course of joint damage in patients with hemophilia A.Patients with hemophilia A (mild, moderate, and severe) were enrolled. The plasma levels of sVCAM-1, E-selectin, and P-selectin in patients with hemophilia A and control were measured using specific enzyme-linked immunosorbent assay kits. Joint damages were evaluated using Pettersson scores.No statistically significant differences were observed in E-selectin and P-selectin levels between patients and controls. The sVCAM-1 level was significantly higher in patients with hemophilia A than in controls. The differences remained significant in patients with severe hemophilia A but not in patients with mild or moderate hemophilia A. The degree of hemophilic arthropathy was evaluated using Pettersson scores, and a score higher than 5 indicated marked arthropathy. Patients with more than 1 joint with marked arthropathy showed significantly higher sVCAM-1 levels.sVCAM-1 levels in patients with hemophilia A are associated with the severity of hemophilic arthropathy.
authors.affiliation: Department of Pediatrics Division of Pediatric Hematology and Oncology, Department of Pediatrics, Kaohsiung Medical University Hospital Department of Pediatrics, School of Medicine, College of Medicine Graduate Institute of Clinical Medicine, Kaohsiung Medical University Department of Nursing Special Hematologic Disease Service Center, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
authors.forename: Yu-Hsin
authors.initials: YH
authors.lastname: Tseng
authors.forename: Shyh-Shin
authors.initials: SS
authors.lastname: Chiou
authors.forename: Yu-Sheng
authors.initials: YS
authors.lastname: Zeng
authors.forename: Shih-Pien
authors.initials: SP
authors.lastname: Tsai
authors.forename: Chun-Shih
authors.initials: CS
authors.lastname: Chen
authors.forename: Yu-Mei
authors.initials: YM
authors.lastname: Liao
authors.forename: Pei-Chin
authors.initials: PC
authors.lastname: Lin
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D019040:E-Selectin / Q000097:blood; D005260:Female; D006467:Hemophilia A / Q000150:complications*; D006801:Humans; D007592:Joint Diseases / Q000097:blood / Q000175:diagnosis / Q000209:etiology; D008297:Male; D008875:Middle Aged; D019007:P-Selectin / Q000097:blood; D011237:Predictive Value of Tests; D012720:Severity of Illness Index; D013223:Statistics as Topic; D013624:Taiwan; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood*
chemical_list: D015415:Biomarkers; D019040:E-Selectin; D019007:P-Selectin; D019010:Vascular Cell Adhesion Molecule-1