title: A Green Approach for Allylations of Aldehydes and Ketones: Combining Allylborate, Mechanochemistry and Lanthanide Catalyst.
abstract: Secondary and tertiary alcohols synthesized via allylation of aldehydes and ketones are important compounds in bioactive natural products and industry, including pharmaceuticals. Development of a mechanochemical method using potassium allyltrifluoroborate salt and water, to successfully perform the allylation of aromatic and aliphatic carbonyl compounds is reported for the first time. By controlling the grinding parameters, the methodology can be selective, namely, very efficient for aldehydes and ineffective for ketones, but by employing lanthanide catalysts, the reactions with ketones can become practically quantitative. The catalyzed reactions can also be performed under mild aqueous stirring conditions. Considering the allylation agent and its by-products, aqueous media, energy efficiency and use of catalyst, the methodology meets most of the green chemistry principles.
authors.affiliation: Departamento de Química Fundamental-Universidade Federal de Pernambuco, Av. Jornalista Aníbal Fernandes, s/n-Cidade Universitária, Recife-PE 50740-560, Brazil. psouza.viviane@gmail.com.
authors.forename: Viviane P
authors.initials: VP
authors.lastname: de Souza
authors.affiliation: Departamento de Química Fundamental-Universidade Federal de Pernambuco, Av. Jornalista Aníbal Fernandes, s/n-Cidade Universitária, Recife-PE 50740-560, Brazil. ckoliveira@gmail.com.
authors.forename: Cristiane K
authors.initials: CK
authors.lastname: Oliveira
authors.affiliation: Departamento de Química Fundamental-Universidade Federal de Pernambuco, Av. Jornalista Aníbal Fernandes, s/n-Cidade Universitária, Recife-PE 50740-560, Brazil. tmsmuniz@gmail.com.
authors.forename: Thiago M
authors.initials: TM
authors.lastname: de Souza
authors.affiliation: Departamento de Química Fundamental-Universidade Federal de Pernambuco, Av. Jornalista Aníbal Fernandes, s/n-Cidade Universitária, Recife-PE 50740-560, Brazil. pmenezes@ufpe.br.
authors.forename: Paulo H
authors.initials: PH
authors.lastname: Menezes
authors.affiliation: Departamento de Química Fundamental-Universidade Federal de Pernambuco, Av. Jornalista Aníbal Fernandes, s/n-Cidade Universitária, Recife-PE 50740-560, Brazil. salvesjr@ufpe.br.
authors.forename: Severino
authors.initials: S
authors.lastname: Alves
authors.affiliation: Departamento de Química Fundamental-Universidade Federal de Pernambuco, Av. Jornalista Aníbal Fernandes, s/n-Cidade Universitária, Recife-PE 50740-560, Brazil. longo@ufpe.br.
authors.forename: Ricardo L
authors.initials: RL
authors.lastname: Longo
authors.affiliation: Departamento de Química Fundamental-Universidade Federal de Pernambuco, Av. Jornalista Aníbal Fernandes, s/n-Cidade Universitária, Recife-PE 50740-560, Brazil. ivani@ufpe.br.
authors.forename: Ivani
authors.initials: I
authors.lastname: Malvestiti
mesh_terms: D000438:Alcohols / Q000737:chemistry; D000447:Aldehydes / Q000138:chemical synthesis / Q000737:chemistry*; D002384:Catalysis; D055772:Green Chemistry Technology; D007659:Ketones / Q000138:chemical synthesis / Q000737:chemistry*; D028581:Lanthanoid Series Elements; D012997:Solvents / Q000737:chemistry
chemical_list: D000438:Alcohols; D000447:Aldehydes; D007659:Ketones; D028581:Lanthanoid Series Elements; D012997:Solvents
keywords: alcohols; catalysis; lanthanide; mechanochemistry; potassium allyltrifluoroborate; selectivity