title: Branched Gold Nanoparticle Coating of Clostridium novyi-NT Spores for CT-Guided Intratumoral Injection.
abstract: Branched gold nanoparticle (BGNP)-coated Clostridium novyi-NT (C. novyi-NT) spores are developed for computed tomography (CT)-guided bacteriolytic tumor therapy. The BGNP-coated spores are successfully injected into a tumor site under CT image guidance. As a result, a strong antitumor effect is observed in a PC3 prostate tumor-bearing mouse model.
authors.affiliation: Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.
authors.forename: Wooram
authors.initials: W
authors.lastname: Park
authors.affiliation: Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.
authors.forename: Soojeong
authors.initials: S
authors.lastname: Cho
authors.affiliation: Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.
authors.forename: Xiaoke
authors.initials: X
authors.lastname: Huang
authors.affiliation: Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.|Robert H. Lurie Comprehensive Cancer Center, Chicago, IL, 60611, USA.|Department of Biomedical Engineering, Northwestern University, Evanston, IL, 60208, USA.|Department of Electrical Engineering and Computer Science, Northwestern University, Evanston, IL, 60208, USA.|International Institute of Nanotechnology (IIN), Northwestern University, Evanston, IL, 60208, USA.
authors.forename: Andrew C
authors.initials: AC
authors.lastname: Larson
authors.affiliation: Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.|Robert H. Lurie Comprehensive Cancer Center, Chicago, IL, 60611, USA.
authors.forename: Dong-Hyun
authors.initials: DH
authors.lastname: Kim
mesh_terms: D003013:Clostridium / Q000502:physiology; D003102:Colloids / Q000737:chemistry; D004563:Electrochemistry; D006046:Gold / Q000737:chemistry*; D015552:Injections, Intralesional; D053768:Metal Nanoparticles / Q000737:chemistry*; D013171:Spores, Bacterial / Q000737:chemistry*; D014465:Ultrasonics
chemical_list: D003102:Colloids; D006046:Gold
keywords: Clostridium novyi-NT; bacteriolytic tumor therapy; computed tomography image-guided therapy; gold nanoparticles