title: Hyperbaric oxygen therapy for traumatic brain injury: bench-to-bedside.
abstract: Traumatic brain injury (TBI) is a serious public health problem in the United States. Survivors of TBI are often left with significant cognitive, behavioral, and communicative disabilities. So far there is no effective treatment/intervention in the daily clinical practice for TBI patients. The protective effects of hyperbaric oxygen therapy (HBOT) have been proved in stroke; however, its efficiency in TBI remains controversial. In this review, we will summarize the results of HBOT in experimental and clinical TBI, elaborate the mechanisms, and bring out our current understanding and opinions for future studies.
authors.affiliation: Discipline of Neuroscience, Department of Anatomy, Histology and Embryology, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Departments of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, CA, USA.
authors.forename: Qin
authors.initials: Q
authors.lastname: Hu
authors.affiliation: Departments of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, CA, USA.
authors.forename: Anatol
authors.initials: A
authors.lastname: Manaenko
authors.affiliation: Departments of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, CA, USA.
authors.forename: Ting
authors.initials: T
authors.lastname: Xu
authors.affiliation: Departments of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, CA, USA.
authors.forename: Zhenni
authors.initials: Z
authors.lastname: Guo
authors.affiliation: Departments of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, CA, USA.
authors.forename: Jiping
authors.initials: J
authors.lastname: Tang
authors.affiliation: Departments of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, CA, USA; Department of Neurosurgery, Loma Linda University School of Medicine, Loma Linda, CA, USA.
authors.forename: John H
authors.identifier: 0000-0002-4319-4285
authors.initials: JH
authors.lastname: Zhang
keywords: apoptosis; hyperbaric oxygen therapy; inflammation; tissue oxygenation; traumatic brain injury