title: Five Years of Multidisciplinary Care in Hereditary Cancer: Our Experience in a Spanish University Hospital.
abstract: OBJECTIVE
  To analyse the evolution of a multidisciplinary heredofamilial cancer unit (HFCU) in a university hospital.
  
  
  METHODS
  This was a retrospective analysis of the activity of our HFCU in its first 5 years of existence.
  
  
  RESULTS
  Between July 2010 and July 2015, 1,518 patients from 1,318 families attended our HFCU. Genetic testing was offered to 862 patients. Of those, 833 (96.6%) accepted testing, with available results for 636 (76.4%). Pathogenic mutations in BRCA1 and BRCA2 were found in 175 patients. Lynch syndrome and adenomatous polyposis were the most frequent syndromes diagnosed (151/175, 86.3%) among 17 different syndromes studied. Of the 404 patients without a previous genetic diagnosis in the family, 62 (15.3%) were found to have mutations in disease-causing genes. Prophylactic surgery and follow-up (33.7%) or follow-up only (66.3%) was proposed for mutation carriers according to international guidelines and patients' preferences.
  
  
  CONCLUSIONS
  We have a high mutation detection rate, genetic test acceptance, and compliance with risk reduction strategies. However, there is room for improvement, especially in genetic testing timing, considering that an increase in the indications for genetic testing is expected.
authors.affiliation: Servicio de Oncología Médica, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.
authors.forename: I
authors.initials: I
authors.lastname: Márquez-Rodas
authors.forename: M
authors.initials: M
authors.lastname: Lobo
authors.forename: C
authors.initials: C
authors.lastname: Flores-Sanchez
authors.forename: M
authors.initials: M
authors.lastname: Sanz
authors.forename: S
authors.initials: S
authors.lastname: Luque
authors.forename: S
authors.initials: S
authors.lastname: Lizarraga
authors.forename: C
authors.initials: C
authors.lastname: González-Asanza
authors.forename: J A
authors.initials: JA
authors.lastname: Pajares
authors.forename: M I
authors.initials: MI
authors.lastname: Peligros
authors.forename: O
authors.initials: O
authors.lastname: Bueno
authors.forename: C
authors.initials: C
authors.lastname: Mata
authors.forename: C
authors.initials: C
authors.lastname: Lopez
authors.forename: S
authors.initials: S
authors.lastname: López-Tarruella
authors.forename: Y
authors.initials: Y
authors.lastname: Jerez
authors.forename: A
authors.initials: A
authors.lastname: Muñoz-Martin
authors.forename: M
authors.initials: M
authors.lastname: Blanco
authors.forename: M
authors.initials: M
authors.lastname: Die-Trill
authors.forename: J P
authors.initials: JP
authors.lastname: Justel
authors.forename: J
authors.initials: J
authors.lastname: Solera
authors.forename: M
authors.initials: M
authors.lastname: Martin
mesh_terms: D005260:Female; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D006785:Hospitals, University / Q000458:organization & administration*; D006801:Humans; D008297:Male; D009386:Neoplastic Syndromes, Hereditary / Q000145:classification / Q000235:genetics / Q000628:therapy*; D012189:Retrospective Studies; D013030:Spain