title: Malaria Parasites: The Great Escape.
abstract: Parasites of the genusPlasmodiumhave a complex life cycle. They alternate between their final mosquito host and their intermediate hosts. The parasite can be either extra- or intracellular, depending on the stage of development. By modifying their shape, motility, and metabolic requirements, the parasite adapts to the different environments in their different hosts. The parasite has evolved to escape the multiple immune mechanisms in the host that try to block parasite development at the different stages of their development. In this article, we describe the mechanisms reported thus far that allow thePlasmodiumparasite to evade innate and adaptive immune responses.
authors.affiliation: Singapore Immunology Network, Agency for Science, Technology and Research (ASTAR) , Singapore.
authors.forename: Laurent
authors.initials: L
authors.lastname: Rénia
authors.affiliation: Singapore Immunology Network, Agency for Science, Technology and Research (ASTAR) , Singapore.
authors.forename: Yun Shan
authors.initials: YS
authors.lastname: Goh
keywords: T cells; antibodies; antigenic polymorphism; antigenic variation; escape mechanism; immunosuppression; malaria; vaccine