title: Family association study of Transforming Growth Factor Beta1 gene polymorphisms in schizophrenia.
abstract: OBJECTIVE
  Schizophrenia is a serious mental illness with chronic symptoms and significant impairment in psychosocial functioning. An etiopathological role for immunologic abnormalities in schizophrenia was hypothesized. Inflammatory markers are well-known etiological factors for psychiatric disorders, including schizophrenia. Several studies have investigated the possible effects of antipsychotics on inflammation and neurogenesis. Additionally, antiinflammatory adjuvant therapy has been under investigation as a treatment option for schizophrenia. Transforming Growth Factor Beta 1 (TGFB1) signaling is critical for many biological processes, including proliferation, development, differentiation and regeneration. Multiple members of the TGFB1 superfamily play a role in the developing nervous system and are regulated by neuronal activity. We conducted family-based study to assess whether TGFB1 gene is associated with susceptibility to schizophrenia in Polish population.
  
  
  METHODS
  Two functional polymorphisms: rs1800469 (C-509T) and rs1800470 (T869C) of TGFB1 gene were analyzed within a group of 147 trios (patients diagnosed with schizophrenia and their healthy parents) using Transmission Disequilibrium Test (TDT).
  
  
  RESULTS
  No association of these polymorphisms with schizophrenia was found in Polish population.
  
  
  CONCLUSIONS
  Further studies on larger groups along with correlation with circulating protein levels are needed.
authors.affiliation: Zakład Genetyki w Psychiatrii Katedry Psychiatrii UM w Poznaniu.
authors.forename: Paweł
authors.initials: P
authors.lastname: Kapelski
authors.affiliation: Zakład Genetyki w Psychiatrii Katedry Psychiatrii UM w Poznaniu.
authors.forename: Maria
authors.initials: M
authors.lastname: Skibińska
authors.affiliation: Pharmacogenetics Research Clinic, Campbell Family Mental Health Research, Institute Centre for Addiction and Mental Health, Toronto, Canada.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Maciukiewicz
authors.affiliation: Zakład Genetyki w Psychiatrii Katedry Psychiatrii UM w Poznaniu.
authors.forename: Dorota
authors.initials: D
authors.lastname: Zaremba
authors.affiliation: Klinika Psychiatrii Dorosłych UM w Poznaniu.
authors.forename: Maria
authors.initials: M
authors.lastname: Jasiak
authors.affiliation: Zakład Genetyki w Psychiatrii Katedry Psychiatrii UM w Poznaniu.
authors.forename: Joanna
authors.initials: J
authors.lastname: Hauser
mesh_terms: D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000235:genetics*; D053773:Transforming Growth Factor beta1 / Q000235:genetics*; D044465:White People / Q000235:genetics*
chemical_list: D053773:Transforming Growth Factor beta1
keywords: Transforming Growth Factor Beta 1; polymorphism; schizophrenia