title: Multi-parametric study of temperature and thermal damage of tumor exposed to high-frequency nanosecond-pulsed electric fields based on finite element simulation.
abstract: High-frequency nanosecond-pulsed electric fields were recently introduced for tumor or abnormal tissue ablation to solve some problems of conventional electroporation. However, it is necessary to study the thermal effects of high-field-intensity nanosecond pulses inside tissues. The multi-parametric analysis performed here is based on a finite element model of liver tissue with a tumor that has been punctured by a pair of needle electrodes. The pulse voltage used in this study ranges from 1 to 4 kV, the pulse width ranges from 50 to 500 ns, and the repetition frequency is between 100 kHz and 1 MHz. The total pulse length is 100 μs, and the pulse burst repetition frequency is 1 Hz. Blood flow and metabolic heat generation have also been considered. Results indicate that the maximum instantaneous temperature at 100 µs can reach 49 °C, with a maximum instantaneous temperature at 1 s of 40 °C, and will not cause thermal damage during single pulse bursts. By parameter fitting, we can obtain maximum instantaneous temperature at 100 µs and 1 s for any parameter values. However, higher temperatures will be achieved and may cause thermal damage when multiple pulse bursts are applied. These results provide theoretical basis of pulse parameter selection for future experimental researches.
authors.affiliation: State Key Laboratory of Power Transmission Equipment & System Security and New Technology, School of Electrical Engineering, Chongqing University, No.174, Shazhengjie Street, Shapingba District, Chongqing, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Mi
authors.affiliation: State Key Laboratory of Power Transmission Equipment & System Security and New Technology, School of Electrical Engineering, Chongqing University, No.174, Shazhengjie Street, Shapingba District, Chongqing, China.|The State Grid Tianjin Power Maintenance Company, No.42, Nankou Street, Hebei District, Tianjin, China.
authors.forename: Shaoqin
authors.initials: S
authors.lastname: Rui
authors.affiliation: State Key Laboratory of Power Transmission Equipment & System Security and New Technology, School of Electrical Engineering, Chongqing University, No.174, Shazhengjie Street, Shapingba District, Chongqing, China. lichengxiang@cqu.edu.cn.
authors.forename: Chengxiang
authors.initials: C
authors.lastname: Li
authors.affiliation: State Key Laboratory of Power Transmission Equipment & System Security and New Technology, School of Electrical Engineering, Chongqing University, No.174, Shazhengjie Street, Shapingba District, Chongqing, China.
authors.forename: Chenguo
authors.initials: C
authors.lastname: Yao
authors.affiliation: State Key Laboratory of Power Transmission Equipment & System Security and New Technology, School of Electrical Engineering, Chongqing University, No.174, Shazhengjie Street, Shapingba District, Chongqing, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Xu
authors.affiliation: State Key Laboratory of Power Transmission Equipment & System Security and New Technology, School of Electrical Engineering, Chongqing University, No.174, Shazhengjie Street, Shapingba District, Chongqing, China.
authors.forename: Changhao
authors.initials: C
authors.lastname: Bian
authors.affiliation: State Key Laboratory of Power Transmission Equipment & System Security and New Technology, School of Electrical Engineering, Chongqing University, No.174, Shazhengjie Street, Shapingba District, Chongqing, China.
authors.forename: Xuefeng
authors.initials: X
authors.lastname: Tang
mesh_terms: D004560:Electricity; D018274:Electroporation; D020342:Finite Element Analysis; D013696:Temperature
keywords: Finite element method; High-frequency nanosecond-pulsed electric fields; Multi-parameters; Temperature; Thermal damage; Tumor