title: Diffuse Alveolar Hemorrhage Associated with Makyo-kanseki-to Administration.
abstract: We herein describe the first known case of diffuse alveolar hemorrhage (DAH) associated with the administration of Makyo-kanseki-to, a Chinese herbal drug. A 64-year-old man with bronchial asthma presented with persistent cough. Makyo-kanseki-to was prescribed as an adjunctive treatment for bronchial asthma. Immediately after drug ingestion, the patient expectorated bloody sputum. DAH was diagnosed based on the presence of bilateral ground-glass opacity which was identified on chest computed tomography and bloody bronchoalveolar lavage fluid. We diagnosed that the administration of Makyo-kanseki-to was the responsible medication because the hemorrhage developed immediately after drug ingestion and resolved after the cessation of such medication with no subsequent recurrence.
authors.affiliation: Division of Respiratory Medicine, Department of Internal Medicine, Nihon University School of Medicine, Japan.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Iida
authors.forename: Yuki
authors.initials: Y
authors.lastname: Takano
authors.forename: Yusaku
authors.initials: Y
authors.lastname: Ishiwatari
authors.forename: Akiko
authors.initials: A
authors.lastname: Yoshida
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Shimizu
authors.forename: Reiko
authors.initials: R
authors.lastname: Ito
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Hattori
authors.forename: Noriaki
authors.initials: N
authors.lastname: Takahashi
authors.forename: Shu
authors.initials: S
authors.lastname: Hashimoto
mesh_terms: D000678:Amygdalin / Q000009:adverse effects*; D001249:Asthma / Q000188:drug therapy*; D001992:Bronchoalveolar Lavage Fluid; D004365:Drugs, Chinese Herbal / Q000009:adverse effects*; D029789:Ephedra / Q000009:adverse effects*; D006469:Hemoptysis / Q000139:chemically induced*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011650:Pulmonary Alveoli
chemical_list: D004365:Drugs, Chinese Herbal; C049093:makyokansekito; D000678:Amygdalin