title: The effects of percutaneous transluminal coronary intervention on biomarkers of oxidative stress in the erythrocytes of elderly male patients.
abstract: OBJECTIVE
  Oxidative stress plays a key role in the pathogenesis of coronary artery disease. The aim of this study was to compare the effects of percutaneous transluminal coronary angioplasty (PTCA) and elective coronary angiography (EC) on erythrocytic antioxidant defense in elderly male patients.
  
  
  METHODS
  Twenty-three stable angina pectoris (SAP) patients undergoing PTCA and 18 patients with ischemic symptoms scheduled to undergo diagnostic EC were included in the study. The concentrations of malondialdehyde (MDA) and reduced glutathione (GSH) and the activities of Zn,Cu-superoxide dismutase (SOD-1), catalase (CAT), and cytosolic glutathione peroxidase (GSH-Px) were examined in the erythrocytes before, immediately after and 2 weeks following PTCA or EC.
  
  
  RESULTS
  The MDA concentrations were significantly higher and SOD-1, CAT, and GSH-Px activities were significantly lower in the PTCA group than in the EC group at baseline. Two weeks after treatment, the activities of the enzymes significantly increased in both groups, whereas the MDA concentrations decreased only in the PTCA patients.
  
  
  CONCLUSIONS
  The results confirm that an advanced state of atherosclerosis is related to greater levels of oxidative stress. The study indicates that both procedures may induce antioxidant defenses; however, PTCA exclusively induces a long-term reduction in lipid peroxidation.
authors.affiliation: a Chair of Medical Biology, Ludwik Rydygier Collegium Medicum in Bydgoszcz , Nicolaus Copernicus University in Toruń , Bydgoszcz , Poland.
authors.forename: Karolina
authors.identifier: http://orcid.org/0000-0001-8123-3882
authors.initials: K
authors.lastname: Szewczyk-Golec
authors.affiliation: b Clinic of Cardiology and Cardiac Surgery , 10. Military Training Hospital , Bydgoszcz , Poland.
authors.forename: Paweł
authors.initials: P
authors.lastname: Grzelakowski
authors.affiliation: b Clinic of Cardiology and Cardiac Surgery , 10. Military Training Hospital , Bydgoszcz , Poland.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Ługowski
authors.affiliation: c Department of Biochemistry, Ludwik Rydygier Collegium Medicum in Bydgoszcz , Nicolaus Copernicus University in Toruń , Bydgoszcz , Poland.
authors.forename: Józef
authors.initials: J
authors.lastname: Kędziora
mesh_terms: D000368:Aged; D000787:Angina Pectoris / Q000097:blood / Q000628:therapy; D015906:Angioplasty, Balloon, Coronary; D000975:Antioxidants / Q000378:metabolism; D002374:Catalase / Q000097:blood; D017023:Coronary Angiography; D005978:Glutathione / Q000097:blood; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood* / Q000628:therapy*; D018384:Oxidative Stress; D013482:Superoxide Dismutase / Q000097:blood
chemical_list: D000975:Antioxidants; D008315:Malondialdehyde; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005978:Glutathione
keywords: Antioxidant enzymes; coronary angiography; coronary angioplasty; ischemic heart disease; lipid peroxidation; oxidative stress