title: The Effect ofOliveria DecumbensandPelargonium Graveolenson Healing of Infected Skin Wounds in Mice.
abstract: BACKGROUND
  Staphylococcus aureusis one of the most causative organisms in the skin wound infections. Development of resistantS. aureusto current treatments in individuals with low immunity is a global concern. The aim of this study was to evaluate the efficacy of herbal formulation against skin wound infection.
  
  
  METHODS
  The efficacy of herbal formulation containingOliveria decumbensandPelargonium graveolensessential oils was evaluated in comparison to mupirocin against Methicillin ResistantS. aureus(MRSA) related skin wound infection in mice animal model.
  
  
  RESULTS
  The herbal cream and mupirocin decreased the log CFU by 2.5±0.26 and 2.46±0.32, respectively, while the log CFU ofS. aureusfrom wound skin were 5.9±0.26 and 5.65±0.23 for placebo and control groups, respectively. Moreover, the histological examinations showed that this cream improved the wound healing and increased the collagen deposition and wound contraction.
  
  
  CONCLUSIONS
  This natural new formulation withO. decumbensandP. graveolensessential oils could be recommended as a new candidate for wound healing.
authors.affiliation: Microbiology Department, Medicinal Plant Research Center of Barij, Kashan, Iran.
authors.forename: Mohaddese
authors.initials: M
authors.lastname: Mahboubi
authors.affiliation: Department of Microbiology, School of Medicine, Tehran University of Medical Science, Tehran, Iran.
authors.forename: Mohammad Mehdi
authors.initials: MM
authors.lastname: Feizabadi
authors.affiliation: Department of Pathology, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, Iran.
authors.forename: Tahereh
authors.initials: T
authors.lastname: Khamechian
authors.affiliation: Microbiology Department, Medicinal Plant Research Center of Barij, Kashan, Iran.
authors.forename: Nastaran
authors.initials: N
authors.lastname: Kazempour
authors.affiliation: Department of Gastroenterology, Beheshti Hospital, Kashan University of Medical Sciences, Kashan, Iran.
authors.forename: Mohsen
authors.initials: M
authors.lastname: Razavi Zadeh
authors.affiliation: Department of Pathology, Faculty of Veterinary Medicine, Tehran University, Tehran, Iran.
authors.forename: Farhang
authors.initials: F
authors.lastname: Sasani
authors.affiliation: Formulation Department, Medicinal Plant Research Center of Barij, Kashan, Iran.
authors.forename: Mohsen
authors.initials: M
authors.lastname: Bekhradi
keywords: Healing; Infected wound; Mouse; Oliveria decumbens; Pelargonium graveolens