title: [New century, new challenges: changes in the burden of disease profile in Brazil, 1990-2010].
abstract: to describe the burden of disease in Brazil from 1990 to 2010.
  
  
  
  analysis of the estimates of the Global Burden of Disease Study 2010 - Years of Life Lost due to premature mortality (YLL), Years Lost due to Disability (YLD), Disability-Adjusted Life Year (DALY=YLL+YLD) and risk factors.
  
  
  
  there was a decrease in deaths due to diarrhea and an increase in deaths due to diabetes and kidney disease, whilst deaths due to homicides and traffic accidents remained stable; cardiovascular diseases continued to be the leading cause of death despite a 30% reduction; the largest increases in DALY were due to diabetes and musculoskeletal diseases in women and alcohol abuse and low back pain in men; the main risk factors were poor diet and high blood pressure; smoking, domestic pollution and insufficient breastfeeding were found to have reduced.
  
  
  
  the rapid epidemiological transition highlights the need to control infectious diseases and invest in reducing violence and non-communicable diseases.
authors.affiliation: Ministério da Saúde, Secretaria de Vigilância em Saúde, Brasília-DF, Brasil.
authors.forename: Fatima
authors.initials: F
authors.lastname: Marinho
authors.affiliation: Universidade Federal de Minas Gerais, Programa de Pós-Graduação em Ciências Aplicadas à Saúde do Adulto, Belo Horizonte-MG, Brasil.
authors.forename: Valéria Maria de Azeredo
authors.initials: VM
authors.lastname: Passos
authors.affiliation: Universidade Federal de Minas Gerais, Programa de Pós-Graduação em Saúde Pública, Belo Horizonte-MG, Brasil.
authors.forename: Elisabeth Barboza
authors.initials: EB
authors.lastname: França
mesh_terms: D001938:Brazil / Q000453:epidemiology; D002423:Cause of Death / Q000639:trends; D006233:Persons with Disabilities / Q000706:statistics & numerical data; D004813:Epidemiology / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D008017:Life Expectancy / Q000639:trends; D008297:Male; D061213:Mortality, Premature / Q000639:trends*; D019057:Quality-Adjusted Life Years; D012307:Risk Factors