title: Effect of 1% Phenytoin Muco-Adhesive Paste on Improvement of Periodontal Status in Patients with Chronic Periodontitis: A Randomized Blinded Controlled Clinical Study.
abstract: BACKGROUND
  Phenytoin (PHT) has been known to promote wound healing in some medical conditions owing to its proliferative as well as anti-inflammatory effects. Yet, its application in oral lesions was less investigated.
  
  
  OBJECTIVE
  The aim of this study was to evaluate changes in periodontal indices following the topical use of phenytoin in chronic periodontitis.
  
  
  METHODS
  In this doubled-blind, randomized, split-mouth controlled clinical study, 20 patients with moderate to severe chronic periodontitis referred to Periodontology Department of Shahid Sadoughi Medical University of Yazd in 2014 were selected consecutively. After initial therapy (scaling and root planning and oral hygiene instructions), periodontal indices including bleeding on probing (BOP), periodontal pocket depth (PPD) and modified gingival index (MGI) were recorded. Gingival facial surface of two posterior sextants with at least two teeth with similar conditions, were selected randomly. Then one surface received PHT paste whereas the other side had placebo as control. Patients were received the mucoadhesive pastes under strict control by an examiner, twice a day for a week. Periodontal indices were measured 3 weeks after treatment. Data was analyzed with t-test and paired t-test by using SPSS 21 software.
  
  
  RESULTS
  It was observed that periodontal pocket depth was significantly more decreased in phenytoin side in comparison with placebo one (p< 0.05). In addition, inflammatory indices including bleeding on probing and modified gingival index declined more in the phenytoin group (p= 0.001 and p< 0.05 respectively).
  
  
  CONCLUSIONS
  These encouraging results support the use of 1% phenytoin mucoadhesive paste as an adjunctive in periodontal treatment.
authors.affiliation: Dept. of Periodontology, Dental Faculty, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
authors.forename: Fahimeh
authors.initials: F
authors.lastname: Rashidi Maybodi
authors.affiliation: Dept. of Periodontology, Dental Faculty, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
authors.forename: Ahmad
authors.initials: A
authors.lastname: Haerian-Ardakani
authors.affiliation: Faculty of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
authors.forename: Mohsen
authors.initials: M
authors.lastname: Nabi-Maybodi
authors.affiliation: Dept. of Periodontology, Dental Faculty, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Nahid
authors.initials: N
authors.lastname: Nasrabadi
keywords:  Chronic periodontitis ;  Mucoadhesive paste ;  Wound healing; Phenytoin 