title: The relationship of urocortin-2 with insulin resistance patients having PCOS.
abstract: In this study, we aimed to compare the serum urocortin-2 (UCN2) levels in women with polycystic ovary syndrome (PCOS) and healthy women. Thirty-eight patients with PCOS and 41 healthy women were included in the study whose age and BMI matched. The fasting serum glucose, insulin, free testosterone, hs-CRP and UCN2 levels of the all participants were examined. HOMA-IR formula was used in order to calculate the insulin resistance. Circulating UCN2 levels were significantly elevated in women with PCOS compared with controls (142.93 ± 59.48 versus 98.56 ± 65.01 pg/ml, p = 0.002). FBG, serum insulin, hs-CRP and HOMA-IR levels were found to be increased in women with PCOS. There was a positive correlation between UCN2 and free-testosterone in only PCOS group (r = 0.235, p = 0.027). Multivariate logistic regression analyses revealed that the odds ratio for PCOS was 2.31 for patients in the highest quartile of UCN2 compared with those in the lowest quartile (OR = 2.31, 95% CI = 1.88-2.83, p=0.021). Multiple linear regression analysis revealed that HOMA-IR, hs-CRP and free-testosterone independently predicted UCN2 levels (p < 0.05). UCN2 levels were significantly higher in PCOS cases when compared to control group. UCN2 is thought to be effective on pathophysiology of PCOS by paracrine and autocrine pathways.
authors.affiliation: a Department of Obstetrics and Gynecology , Manisa Merkezefendi Hospital , Manisa , Turkey.|b Department of Obstetrics and Gynecology , Sakarya University Faculty of Medicine , Sakarya , Turkey.
authors.forename: Muzaffer
authors.initials: M
authors.lastname: Temur
authors.affiliation: c Manisa Merkezefendi State Hospital Department of Obstetrics and Gynecology , Manisa , Turkey.
authors.forename: Özgür
authors.initials: Ö
authors.lastname: Yılmaz
authors.affiliation: d Department of Medical Biochemistry İzmir , İzmir Katipcelebi University Medical School , İzmir , Turkey.
authors.forename: Saliha
authors.initials: S
authors.lastname: Aksun
authors.affiliation: e Department of Endocrinology İzmir , İzmir Bozyaka Education and Research Hospital , İzmir , Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Calan
authors.affiliation: f Aydın Private Ege Liva Hospital Department of Obstetrics and Gynecology Aydın , Aydın , Turkey , and.
authors.forename: Pelin
authors.initials: P
authors.lastname: Özün Özbay
authors.affiliation: g Department of Obstetrics and Gynecology , Sakarya University School of Medicine, Sakarya Research and Education Hospital , Sakarya , Turkey.
authors.forename: Serkan
authors.initials: S
authors.lastname: Kumbasar
authors.affiliation: g Department of Obstetrics and Gynecology , Sakarya University School of Medicine, Sakarya Research and Education Hospital , Sakarya , Turkey.
authors.forename: Erman
authors.initials: E
authors.lastname: Sever
mesh_terms: D000328:Adult; D002097:C-Reactive Protein / Q000378:metabolism*; D003346:Corticotropin-Releasing Hormone / Q000097:blood*; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D011085:Polycystic Ovary Syndrome / Q000097:blood*; D013739:Testosterone / Q000097:blood*; D054832:Urocortins / Q000097:blood*; D055815:Young Adult
chemical_list: C426705:UCN2 protein, human; D054832:Urocortins; D013739:Testosterone; D002097:C-Reactive Protein; D003346:Corticotropin-Releasing Hormone
keywords: Insulin; PCOS; urocortin-2