title: Impact of Treatment-Related Beliefs on Medication Adherence in Immune-Mediated Inflammatory Diseases: Results of the Global ALIGN Study.
abstract: Medication adherence is critical in chronic immune-mediated inflammatory diseases (IMIDs) and could be affected by patients' treatment-related beliefs. The objective of this study was to determine beliefs about systemic medications in patients with IMIDs and to explore the association of those beliefs and other factors with adherence.
  
  
  
  This was a multi-country, cross-sectional, self-administered survey study. Included were adults diagnosed with one of six IMIDs receiving conventional systemic medications and/or tumor necrosis factor inhibitors (TNFi). Patients' necessity beliefs/concerns towards and adherence to treatments were assessed by the Beliefs about Medicines Questionnaire and four-item Morisky Medication Adherence Scale. Correlation of patients' beliefs about treatment and other factors with adherence were evaluated by multivariable regression analyses.
  
  
  
  Among studied patients (N = 7197), 32.0% received TNFi monotherapy, 27.7% received TNFi-conventional combination therapy, and 40.3% received conventional medications. Across IMIDs, high adherence to systemic treatment was more prevalent in TNFi groups (61.3-80.7%) versus corresponding conventional treatment groups (28.4-64.7%). In at least four IMIDs, greater perception of the illness continuing forever (P < 0.001), of the treatment helping (P < 0.001), and more concerns about the illness (P < 0.01), but not clinical parameters, were associated with higher treatment necessity beliefs. Higher treatment necessity beliefs, older age, Caucasian race, and TNFi therapy were associated with high medication adherence in at least four IMIDs.
  
  
  
  Treatment necessity beliefs were higher than concerns about current medication in patients with IMID. Illness perceptions had a greater impact on treatment necessity beliefs than clinical parameters. Older age, greater treatment necessity beliefs, and TNFi therapy were associated with high self-reported medication adherence in at least four IMIDs.
  
  
  
  ACTRN12612000977875.
  
  
  
  AbbVie.
authors.affiliation: Crohn and Colitis Centre, Gastro-entérologie La Source-Beaulieu and Division of Gastroenterology, Centre Hospitalier Universitaire Vaudois, 1004, Lausanne, Switzerland. pmichetti@gesb.ch.
authors.forename: Pierre
authors.initials: P
authors.lastname: Michetti
authors.affiliation: Institute of Pharmaceutical Sciences, King's College London, London, UK.
authors.forename: John
authors.initials: J
authors.lastname: Weinman
authors.affiliation: Psoriasis-Center at the Department of Dermatology, Venereology and Allergology, University Medical Center Schleswig-Holstein, Campus Kiel, Kiel, Germany.
authors.forename: Ulrich
authors.initials: U
authors.lastname: Mrowietz
authors.affiliation: Division of Rheumatology, Department of Medicine 3, Medical University of Vienna, Vienna, Austria.|2nd Department of Medicine, Center for Rheumatic Diseases, Hietzing Hospital, Vienna, Austria.
authors.forename: Josef
authors.initials: J
authors.lastname: Smolen
authors.affiliation: Inserm U954 and Department of Gastroenterology, Université de Lorraine, Vandoeuvre-les-Nancy, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Peyrin-Biroulet
authors.affiliation: CHU de Liège et Université de Liège, Liège, Belgium.
authors.forename: Edouard
authors.initials: E
authors.lastname: Louis
authors.affiliation: GKM Gesellschaft für Therapieforschung mbH, Munich, Germany.
authors.forename: Dieter
authors.initials: D
authors.lastname: Schremmer
authors.affiliation: AbbVie Inc., North Chicago, IL, USA.
authors.forename: Namita
authors.initials: N
authors.lastname: Tundia
authors.affiliation: Medical Department, AbbVie Deutschland GmbH & Co. KG, Wiesbaden, Germany.
authors.forename: Pascal
authors.initials: P
authors.lastname: Nurwakagari
authors.affiliation: Global Medical Affairs, AbbVie Inc., North Chicago, IL, USA.
authors.forename: Nicole
authors.initials: N
authors.lastname: Selenko-Gebauer
mesh_terms: D000328:Adult; D000367:Age Factors; D001327:Autoimmune Diseases / Q000188:drug therapy* / Q000523:psychology; D002908:Chronic Disease; D003431:Cross-Cultural Comparison; D003430:Cross-Sectional Studies; D005260:Female; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D008297:Male; D055118:Medication Adherence / Q000523:psychology*; D008875:Middle Aged; D057566:Self Report; D011795:Surveys and Questionnaires; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors*
chemical_list: D014409:Tumor Necrosis Factor-alpha
keywords: Crohn’s disease; Cross-sectional study; Illness perception; Medication beliefs; Rheumatoid arthritis; Ulcerative colitis