title: HMGA1 is a novel candidate gene for myocardial infarction susceptibility.
abstract: BACKGROUND
  Acute Myocardial infarction (AMI), a leading cause of morbidity and mortality worldwide, is a dreadful acute complication of coronary atherosclerosis. Type 2 diabetes mellitus (T2DM) is associated with an increased risk of developing AMI. The architectural transcription factor high-mobility-group AT-hook 1 (HMGA1) has been involved in atherosclerosis, plaque formation, inflammation, and in the pathogenesis of insulin resistance and T2DM. An association of the HMGA1 rs146052672 variant with T2DM has been recently reported. Thus, our aim was to evaluate whether this variant was also associated with AMI.
  
  
  RESULTS
  In a case-control study from Calabria (Southern Italy), we enrolled 254 consecutive, unrelated, patients with first diagnosis of AMI, and 508 age, sex-matched controls. Genotyping of the rs146052672 was performed using the TaqMan allelic discrimination method. We found that this variant was present in 7.9% of AMI patients and in 3.1% of controls (p=0.003). Multiple logistic regression confirmed that the rs146052672 was significantly associated with AMI (OR=2.54; p=0.002), and this association was independent of classical cardiovascular risk factors such as gender, hypertension, obesity and T2DM (for all, p<0.05).
  
  
  CONCLUSIONS
  Our findings demonstrate that a relationship exists between the HMGA1 rs146052672 variant and AMI, suggesting that defects at the HMGA1 locus may play a pathogenetic role in AMI, in the absence of T2DM and other cardiovascular risk factors.
authors.affiliation: Division of Cardiology, Department of Medical and Surgical Sciences, "Magna Graecia" University, Catanzaro, Italy.
authors.forename: Salvatore
authors.initials: S
authors.lastname: De Rosa
authors.affiliation: Department of Health Sciences, University "Magna Græcia" of Catanzaro, 88100 Catanzaro, Italy.
authors.forename: Eusebio
authors.initials: E
authors.lastname: Chiefari
authors.affiliation: Division of Cardiology, Department of Medical and Surgical Sciences, "Magna Graecia" University, Catanzaro, Italy.
authors.forename: Nadia
authors.initials: N
authors.lastname: Salerno
authors.affiliation: Department of Health Sciences, University "Magna Græcia" of Catanzaro, 88100 Catanzaro, Italy.
authors.forename: Valeria
authors.initials: V
authors.lastname: Ventura
authors.affiliation: Division of Cardiology, Department of Medical and Surgical Sciences, "Magna Graecia" University, Catanzaro, Italy.
authors.forename: Greta Luana
authors.initials: GL
authors.lastname: D'Ascoli
authors.affiliation: Department of Health Sciences, University "Magna Græcia" of Catanzaro, 88100 Catanzaro, Italy.
authors.forename: Biagio
authors.initials: B
authors.lastname: Arcidiacono
authors.affiliation: Division of Cardiology, Department of Medical and Surgical Sciences, "Magna Graecia" University, Catanzaro, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Ambrosio
authors.affiliation: Department of Health Sciences, University "Magna Græcia" of Catanzaro, 88100 Catanzaro, Italy.
authors.forename: Francesco Luciano
authors.initials: FL
authors.lastname: Bilotta
authors.affiliation: Division of Cardiology, Department of Medical and Surgical Sciences, "Magna Graecia" University, Catanzaro, Italy.
authors.forename: Daniele
authors.initials: D
authors.lastname: Torella
authors.affiliation: Department of Health Sciences, University "Magna Græcia" of Catanzaro, 88100 Catanzaro, Italy.
authors.forename: Daniela
authors.initials: D
authors.lastname: Foti
authors.affiliation: Division of Cardiology, Department of Medical and Surgical Sciences, "Magna Graecia" University, Catanzaro, Italy; URT-CNR, Department of Medicine, Consiglio Nazionale delle Ricerche of IFC, Catanzaro, Italy. Electronic address: indolfi@unicz.it.
authors.forename: Ciro
authors.initials: C
authors.lastname: Indolfi
authors.affiliation: Department of Health Sciences, University "Magna Græcia" of Catanzaro, 88100 Catanzaro, Italy. Electronic address: brunetti@unicz.it.
authors.forename: Antonio
authors.initials: A
authors.lastname: Brunetti
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D025741:HMGA1a Protein / Q000235:genetics*; D006801:Humans; D007558:Italy; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics
chemical_list: D025741:HMGA1a Protein
keywords: Acute myocardial infarction; Diabetes; Polymorphism; Risk factors