title: The effect of a liver-X-receptor ligand on bleomycin induced pulmonary fibrosis in mice.
abstract: The liver-X-receptors have shown anti-fibrosis ability in several animal models. Our purpose was to investigate the effect of LXRs in bleomycin induced lung fibrosis in mice. Bleomycin was intratracheally delivered to mice. Some mice were administered a LXR agonist, T0901317. Then mice were evaluated for the development of lung inflammation and fibrosis. T0901317 was able to attenuate the inflammation and fibrosis induced by bleomycin. T0901317 treatment evidently abolished the high level of TGF-β1 and inhibited NF-κB DNA-binding activity in lung. So LXRs may attenuate the progressing of lung fibrosis, providing a potential treatment of IPF.
authors.affiliation: Department of Respiratory Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Shi
authors.affiliation: Yancheng City No. 1 People's Hospital, Yan Cheng, China.
authors.forename: Qiongju
authors.initials: Q
authors.lastname: Chen
authors.affiliation: Department of Respiratory Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
authors.forename: Haijun
authors.initials: H
authors.lastname: Yan
authors.affiliation: Department of Respiratory Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Gu
mesh_terms: D064286:ATP Binding Cassette Transporter 1 / Q000235:genetics; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001761:Bleomycin; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry; D016207:Cytokines / Q000378:metabolism; D005260:Female; D005353:Fibronectins / Q000378:metabolism; D006845:Hydrocarbons, Fluorinated / Q000494:pharmacology / Q000627:therapeutic use*; D008024:Ligands; D000071518:Liver X Receptors / Q000378:metabolism; D008168:Lung / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008810:Mice, Inbred C57BL; D016328:NF-kappa B / Q000378:metabolism; D011658:Pulmonary Fibrosis / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D012333:RNA, Messenger / Q000378:metabolism; D058258:Serpin E2 / Q000378:metabolism; D013449:Sulfonamides / Q000494:pharmacology / Q000627:therapeutic use*; D005466:Fluorocarbons; D000096926:Benzenesulfonamides
chemical_list: D064286:ATP Binding Cassette Transporter 1; D000893:Anti-Inflammatory Agents; D001761:Bleomycin; D016207:Cytokines; D005353:Fibronectins; D006845:Hydrocarbons, Fluorinated; D008024:Ligands; D000071518:Liver X Receptors; D016328:NF-kappa B; D012333:RNA, Messenger; D058258:Serpin E2; D013449:Sulfonamides; C577833:Abca1 protein, mouse; C511869:Serpine2 protein, mouse; C423915:T0901317; D005466:Fluorocarbons; D000096926:Benzenesulfonamides
keywords: Bleomycin; Liver X receptors; Pulmonary fibrosis