title: Clomiphene Citrate versus Letrozole for Ovarian Stimulation in Therapeutic Donor Sperm Insemination.
abstract: OBJECTIVE
  To compare clomiphene citrate (CC) and letrozole for ovarian stimulation (OS) in therapeutic donor sperm insemination (TDI) cycles.
  
  
  METHODS
  Retrospective cohort study between January 2011 and June 2014 at a University-affiliated private IVF clinic in Montreal, Canada. 257 normo-ovulatory women ≤40 years of age with no history of infertility undergoing 590 TDI cycles in the absence of a male partner (single women and same-sex couples) or azoospermia were included. Patients received 100 mg CC daily (145 women, 321 cycles) or letrozole 5 mg daily (112 women, 269 cycles), from days 3 to 7. Only the first 3 cycles were included per patient. Our main outcome measure was cumulative live birth rates (LBR).
  
  
  RESULTS
  Baseline characteristics were comparable between the 2 groups. There were no differences in LBR per cycle (16.5% (53/321) vs. 11.5% (31/269), p = 0.08) and cumulative LBR (36.6% (53/145) vs. 27.7% (31/112), p = 0.13), between CC and letrozole, respectively. Multiple pregnancy rate (11.6% (8/69) vs. 8.7% (4/46), p = 0.6) and miscarriage rate (21.7 vs. 21.7%, p = 1) were also comparable between CC and letrozole, respectively.
  
  
  CONCLUSIONS
  In normo-ovulatory women undergoing TDI, OS with CC or letrozole resulted in similar live birth and twin pregnancy rates.
authors.affiliation: Department of Reproductive Medicine, Ovo Clinic, University of Montreal, Montreal, Que., Canada.
authors.forename: Hady
authors.initials: H
authors.lastname: El Hachem
authors.forename: Roland
authors.initials: R
authors.lastname: Antaki
authors.forename: Camille
authors.initials: C
authors.lastname: Sylvestre
authors.forename: Isaac-Jacques
authors.initials: IJ
authors.lastname: Kadoch
authors.forename: Louise
authors.initials: L
authors.lastname: Lapensée
authors.forename: Pierre Emmanuel
authors.initials: PE
authors.lastname: Bouet
mesh_terms: D000328:Adult; D047072:Aromatase Inhibitors; D002170:Canada; D002996:Clomiphene / Q000008:administration & dosage*; D005260:Female; D005300:Fertility Agents, Female; D006801:Humans; D007248:Infertility, Male / Q000628:therapy; D007316:Insemination, Artificial, Heterologous / Q000379:methods*; D000077289:Letrozole; D050498:Live Birth; D008297:Male; D009570:Nitriles / Q000008:administration & dosage*; D010062:Ovulation Induction / Q000379:methods*; D011247:Pregnancy; D011256:Pregnancy Outcome; D018873:Pregnancy Rate; D012189:Retrospective Studies; D014019:Tissue Donors; D014230:Triazoles / Q000008:administration & dosage*
chemical_list: D047072:Aromatase Inhibitors; D005300:Fertility Agents, Female; D009570:Nitriles; D014230:Triazoles; D002996:Clomiphene; D000077289:Letrozole
keywords: Clomiphene citrate; Letrozole; Live birth; Ovarian stimulation; Therapeutic donor sperm insemination