title: Cases with Refractory Ascites and a Delayed Response to Tolvaptan.
abstract: The patient was a 67-year-old female with liver cirrhosis due to hepatitis C. She was administered furosemide at 20 mg/day and spironolactone at 25 mg/day, but the ascites did not improve. Despite the additional administration of tolvaptan at 3.75 mg/day, the response to ascites was still poor. While the dose of tolvaptan was thereafter increased to 7.5 mg/day on the 7th hospital day, the ascites still persisted. However, she continued to receive tolvaptan (7.5 mg/day) because the worsening of her subjective symptoms was mild and she wished to do so. The ascites was later found to have almost completely disappeared on computed tomography (CT) at 6 months.
authors.affiliation: Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Japan.
authors.forename: Satoru
authors.initials: S
authors.lastname: Hagiwara
authors.forename: Naoshi
authors.initials: N
authors.lastname: Nishida
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Chishina
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ida
authors.forename: Toshiharu
authors.initials: T
authors.lastname: Sakurai
authors.forename: Yoriaki
authors.initials: Y
authors.lastname: Komeda
authors.forename: Masayuki
authors.initials: M
authors.lastname: Kitano
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Kudo
mesh_terms: D000368:Aged; D065092:Antidiuretic Hormone Receptor Antagonists / Q000627:therapeutic use*; D001201:Ascites / Q000000981:diagnostic imaging / Q000188:drug therapy*; D001552:Benzazepines / Q000627:therapeutic use*; D004232:Diuretics / Q000627:therapeutic use; D004334:Drug Administration Schedule; D005260:Female; D005665:Furosemide / Q000627:therapeutic use; D006526:Hepatitis C / Q000150:complications; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications; D013148:Spironolactone / Q000627:therapeutic use; D000077602:Tolvaptan; D014057:Tomography, X-Ray Computed
chemical_list: D065092:Antidiuretic Hormone Receptor Antagonists; D001552:Benzazepines; D004232:Diuretics; D000077602:Tolvaptan; D013148:Spironolactone; D005665:Furosemide