title: The rs4285184 polymorphism of the MGAT1 gene as a risk factor for obesity in the Mexican population.
abstract: OBJECTIVE
  Obesity is a factor that contributes to the morbidity of certain diseases and to worldwide mortality. MGAT1 is a glycosyltransferase involved in the synthesis of protein-bound and lipid-bound oligosaccharides and its polymorphisms are possibly involved in the etiology of obesity. We investigated the association of the rs4285184 polymorphism of the MGAT1 gene with obesity in adults in the State of Colima, Mexico.
  
  
  METHODS
  A case-control study was conducted that included 244 subjects. All of them were grouped according to their percentage of body fat, determined through bioelectrical impedance, and they were genotyped for the rs4285184 polymorphism of the MGAT1 gene through PCR-RFLP. The results were analyzed for their association with the percentage of body fat.
  
  
  RESULTS
  The G allele had a frequency of 49.19 and 38.75% for the cases and controls, respectively (P=.020) (OR 1.53; 95% CI 1.068-2.193). The frequency of the A/G+G/G genotype was 75% in the obese patients, which was significantly higher compared with the 57.5% of the control group (P=.004) (OR 2.217; 95% CI 1.287-3.821).
  
  
  CONCLUSIONS
  The presence of the rs4285184 polymorphism of the MGAT1 gene increased the risk for developing body fat associated with obesity in the Mexican population.
authors.affiliation: University Biomedical Research Center, Universidad de Colima, Colima, México; Centro Universitario del Sur, Universidad de Guadalajara, Guzmán, Jalisco, México.
authors.forename: José C
authors.initials: JC
authors.lastname: Tapia-Rivera
authors.affiliation: Faculty of Medicine, Universidad de Colima, Colima, México.
authors.forename: Luz M
authors.initials: LM
authors.lastname: Baltazar-Rodríguez
authors.affiliation: University Biomedical Research Center, Universidad de Colima, Colima, México; Clinical Epidemiology Research Unit, Hospital General de Zona UMF N.(o) 1 IMSS, Colima, México.
authors.forename: Martha I
authors.initials: MI
authors.lastname: Cárdenas-Rojas
authors.affiliation: Faculty of Medicine, Universidad de Colima, Colima, México.
authors.forename: Alan
authors.initials: A
authors.lastname: Álvarez
authors.affiliation: Centro Universitario del Sur, Universidad de Guadalajara, Guzmán, Jalisco, México.
authors.forename: Rafael
authors.initials: R
authors.lastname: Bustos-Saldaña
authors.affiliation: Faculty of Medicine, Universidad de Colima, Colima, México.
authors.forename: Iván
authors.initials: I
authors.lastname: Delgado-Enciso
authors.affiliation: Faculty of Chemical Sciences, Universidad de Colima, Colima, México.
authors.forename: Laura L
authors.initials: LL
authors.lastname: Valdez-Velázquez
authors.affiliation: Centro Universitario del Sur, Universidad de Guadalajara, Guzmán, Jalisco, México. Electronic address: pepeguzman_esquivel@outlook.com.
authors.forename: José
authors.initials: J
authors.lastname: Guzmán-Esquivel
authors.affiliation: University Biomedical Research Center, Universidad de Colima, Colima, México.
authors.forename: Mario
authors.initials: M
authors.lastname: Ramírez-Flores
mesh_terms: D000293:Adolescent; D000328:Adult; D054458:Amplified Fragment Length Polymorphism Analysis; D016022:Case-Control Studies; D005260:Female; D005819:Genetic Markers; D006801:Humans; D008297:Male; D008800:Mexico; D008875:Middle Aged; D017351:N-Acetylglucosaminyltransferases / Q000235:genetics*; D009765:Obesity / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D055815:Young Adult
chemical_list: D005819:Genetic Markers; C561128:MGAT1 protein, human; D017351:N-Acetylglucosaminyltransferases
keywords: Asociación; Association; Gen; Gene; Obesidad; Obesity; Polimorfismo; Polymorphism