title: Protective effect of tetrahydroxy stilbene glucoside on learning and memory by regulating synaptic plasticity.
abstract: Damage to synaptic plasticity induced by neurotoxicity of amyloid-beta is regarded to be one of the pathological mechanisms of learning and memory disabilities in Alzheimer's disease patients. This study assumed that the damage of amyloid-beta to learning and memory abilities was strongly associated with the changes in the Fyn/N-methyl-D-aspartate receptor 2B (NR2B) expression. An APP695V7171 transgenic mouse model of Alzheimer's disease was used and treatment with tetrahydroxy-stilbene glucoside was administered intragastrically. Results showed that intragastric administration of tetrahydroxy-stilbene glucoside improved the learning and memory abilities of the transgenic mice through increasing NR2B receptors and Fyn expression. It also reversed parameters for synaptic interface structure of gray type I. These findings indicate that tetrahydroxy stilbene glucoside has protective effects on the brain, and has prospects for its clinical application to improve the learning and memory abilities and treat Alzheimer's disease.
authors.affiliation: Department of Neurology, Lanzhou General Hospital, Lanzhou Military Area Command, Lanzhou, Gansu Province, China.
authors.forename: Hong-Bo
authors.initials: HB
authors.lastname: Luo
authors.affiliation: Department of Neurology, Lanzhou General Hospital, Lanzhou Military Area Command, Lanzhou, Gansu Province, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Neurology, China-Japan Friendship Hospital, Beijing, China.
authors.forename: Zun-Jing
authors.initials: ZJ
authors.lastname: Liu
authors.affiliation: Department of Neurology, Lanzhou General Hospital, Lanzhou Military Area Command, Lanzhou, Gansu Province, China.
authors.forename: Li
authors.initials: L
authors.lastname: Cao
authors.affiliation: Department of Neurology, Lanzhou General Hospital, Lanzhou Military Area Command, Lanzhou, Gansu Province, China.
authors.forename: Zhi-Qiang
authors.initials: ZQ
authors.lastname: Zhang
authors.affiliation: Department of Neurology, Lanzhou General Hospital, Lanzhou Military Area Command, Lanzhou, Gansu Province, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Neurology, Lanzhou General Hospital, Lanzhou Military Area Command, Lanzhou, Gansu Province, China.
authors.forename: Xiao-Yan
authors.initials: XY
authors.lastname: Zhang
authors.affiliation: Department of Neurology, Lanzhou General Hospital, Lanzhou Military Area Command, Lanzhou, Gansu Province, China.
authors.forename: Zhao
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Department of Neurology, Lanzhou General Hospital, Lanzhou Military Area Command, Lanzhou, Gansu Province, China.
authors.forename: Xiang-Qun
authors.identifier: 0000-0002-4567-2244
authors.initials: XQ
authors.lastname: Shi
keywords: Alzheimer's disease; Fyn/N-methyl-D-aspartate receptor 2B signaling pathway; amyloid-beta; cognitive impairment; learning and memory; nerve regeneration; neural regeneration; neuroprotection; synaptic plasticity; tetrahydroxy stilbene glucoside