title: Nanotechnology in Glycomics: Applications in Diagnostics, Therapy, Imaging, and Separation Processes.
abstract: This review comprehensively covers the most recent achievements (from 2013) in the successful integration of nanomaterials in the field of glycomics. The first part of the paper addresses the beneficial properties of nanomaterials for the construction of biosensors, bioanalytical devices, and protocols for the detection of various analytes, including viruses and whole cells, together with their key characteristics. The second part of the review focuses on the application of nanomaterials integrated with glycans for various biomedical applications, that is, vaccines against viral and bacterial infections and cancer cells, as therapeutic agents, for in vivo imaging and nuclear magnetic resonance imaging, and for selective drug delivery. The final part of the review describes various ways in which glycan enrichment can be effectively done using nanomaterials, molecularly imprinted polymers with polymer thickness controlled at the nanoscale, with a subsequent analysis of glycans by mass spectrometry. A short section describing an active glycoprofiling by microengines (microrockets) is covered as well.
authors.affiliation: Department of Glycobiotechnology, Institute of Chemistry, Slovak Academy of Sciences, Dubravska cesta 9, 845 38, Bratislava, Slovakia.
authors.forename: Erika
authors.initials: E
authors.lastname: Dosekova
authors.affiliation: Center for Advanced Materials, Qatar University, P.O. Box 2713, Doha, Qatar.
authors.forename: Jaroslav
authors.initials: J
authors.lastname: Filip
authors.affiliation: Department of Glycobiotechnology, Institute of Chemistry, Slovak Academy of Sciences, Dubravska cesta 9, 845 38, Bratislava, Slovakia.
authors.forename: Tomas
authors.initials: T
authors.lastname: Bertok
authors.affiliation: School of Chemistry, Manchester Institute of Biotechnology, The University of Manchester, 131 Princess Street, Manchester, M1 7DN, UK.
authors.forename: Peter
authors.initials: P
authors.lastname: Both
authors.affiliation: Center for Advanced Materials, Qatar University, P.O. Box 2713, Doha, Qatar.
authors.forename: Peter
authors.initials: P
authors.lastname: Kasak
authors.affiliation: Department of Glycobiotechnology, Institute of Chemistry, Slovak Academy of Sciences, Dubravska cesta 9, 845 38, Bratislava, Slovakia.
authors.forename: Jan
authors.initials: J
authors.lastname: Tkac
mesh_terms: D000818:Animals; D015374:Biosensing Techniques; D003952:Diagnostic Imaging / Q000379:methods*; D016503:Drug Delivery Systems; D054794:Glycomics / Q000379:methods*; D006801:Humans; D050997:Nanomedicine / Q000379:methods*; D036103:Nanotechnology / Q000379:methods*
keywords: cell tissue targeting/imaging and drug delivery; glycan enrichment and active glycoprofiling; glycan sensing; glycan-based vaccines/therapeutics; glycomics; nanomaterials; nanotechnology