title: SERPINE1 -844 and -675 polymorphisms and chronic obstructive pulmonary disease in a Chinese Han population.
abstract: Objective To investigate the association between serpin family E member 1 ( SERPINE1) -844 A/G and -675 4G/5G polymorphisms and chronic obstructive pulmonary disease (COPD) in a Chinese Han population. Method SERPINE1 -844 A/G and -675 4G/5G polymorphisms were assessed by polymerase chain reaction-restriction fragment length polymorphism sequencing of genomic DNA from patients with COPD and healthy smoking controls. Results Out of 140 patients with COPD and 100 controls, all SERPINE1 -844 and -675 polymorphisms were in Hardy-Weinberg equilibrium. Differences in SERPINE1 -675 4G and 5G allele frequencies were statistically significant between the COPD and control groups (odds ratio [OR] 1.45, 95% confidence interval [CI] 1.00, 2.09), but there was no significant between-group difference in SERPINE1 -844 A and G allele frequencies. The SERPINE1 -675 4G/4G genotype was associated with COPD (OR 1.87, 95% CI 1.06, 3.32 [binary logistic regression]). Haplotype analysis showed that COPD was associated with SERPINE1 -844G/4G (OR 2.11, 95% CI 1.32, 3.38) and SERPINE1 -844G/5G (OR 0.66, 95% CI 0.45, 0.95). Conclusion The SERPINE1 -675 polymorphism, but not SERPINE1 -844 polymorphism, was associated with susceptibility to COPD in a Chinese Han population.
authors.affiliation: 1 Department of Geriatrics, Qilu Hospital, Shandong University, Jinan, China.
authors.forename: Xia
authors.initials: X
authors.lastname: Xu
authors.affiliation: 2 Department of Pulmonary Medicine, Jinan Central Hospital, Shandong University, Jinan, China.
authors.forename: Hongchao
authors.initials: H
authors.lastname: Wang
authors.affiliation: 1 Department of Geriatrics, Qilu Hospital, Shandong University, Jinan, China.
authors.forename: Haijun
authors.initials: H
authors.lastname: Li
authors.affiliation: 1 Department of Geriatrics, Qilu Hospital, Shandong University, Jinan, China.
authors.forename: Xiaopei
authors.initials: X
authors.lastname: Cui
authors.affiliation: 1 Department of Geriatrics, Qilu Hospital, Shandong University, Jinan, China.
authors.forename: Hongyu
authors.initials: H
authors.lastname: Zhang
mesh_terms: D000368:Aged; D000483:Alleles; D044466:Asian People; D016022:Case-Control Studies; D005260:Female; D015870:Gene Expression; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D017395:Plasminogen Activator Inhibitor 1 / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D029424:Pulmonary Disease, Chronic Obstructive / Q000208:ethnology / Q000235:genetics* / Q000473:pathology
chemical_list: D017395:Plasminogen Activator Inhibitor 1; C051321:SERPINE1 protein, human
keywords: Chronic obstructive pulmonary disease; plasminogen activator inhibitor-1; single-nucleotide polymorphism