title: The effect of preoperative dexamethasone on pain 1 year after lumbar disc surgery: a follow-up study.
abstract: It has been hypothesized that dexamethasone can inhibit persistent postoperative pain, but data on humans is lacking and results from animal studies are conflicting. We explored the effect of 16 mg dexamethasone IV administered preoperatively on persistent pain 1 year after lumbar discectomy.
  
  
  
  This is a prospective 1-year follow-up on a single-centre, randomized, and blinded trial exploring the analgesic effect of 16 mg IV dexamethasone or placebo after lumbar discectomy. One year follow-up was a written questionnaire including back and leg pain (VAS 0-100 mm), Short Form 36 survey (SF-36), EuroQol 5D (EQ-5D), OSWESTRY Low Back Pain Questionnaire, duration of sick leave, working capability, contentment with surgical result.
  
  
  
  Response rate was 71% (55 patients) in the dexamethasone group, 58% (44 patients) in the placebo group. Leg pain (VAS) was significantly lower in the placebo group compared to the dexamethasone group: 17 (95% CI 10-26) vs 26 (95% CI 19-33) mm, respectively (mean difference 9 mm (95% CI -1 to 0), (P = 0.03). No difference regarding back pain. The placebo group reported significantly more improvement of leg pain and were significantly more satisfied with the surgical result. Patients in the dexamethasone group reported significantly higher pain levels in EQ-5D- and Oswestry questionnaires. No difference in the SF-36 survey or daily analgesic consumption.
  
  
  
  We found significantly higher pain levels in the dexamethasone group compared to placebo 1 year after lumbar disc surgery.
  
  
  
  Clinicaltrials.gov ( NCT01953978 ). Registered 26 Sep 2013.
authors.affiliation: Department of Neuroanaesthesiology, Rigshospitalet, Glostrup University Hospital, Nordre Ringvej 57, 2600, Glostrup, Denmark. rikkevibeke@gmail.com.
authors.forename: Rikke Vibeke
authors.initials: RV
authors.lastname: Nielsen
authors.affiliation: Department of Neuroanaesthesiology, Rigshospitalet, Glostrup University Hospital, Glostrup, Denmark.
authors.forename: Jonna
authors.initials: J
authors.lastname: Fomsgaard
authors.affiliation: Department of Anaesthesiology, University Hospital Zealand, Køge Hospital, Køge, Denmark.
authors.forename: Ole
authors.initials: O
authors.lastname: Mathiesen
authors.affiliation: Department of Anaesthesiology, Bispebjerg Hospital, Copenhagen University Hospital, København, Denmark.
authors.forename: Jørgen Berg
authors.initials: JB
authors.lastname: Dahl
mesh_terms: D059350:Chronic Pain / Q000453:epidemiology; D003907:Dexamethasone / Q000008:administration & dosage*; D017586:Diskectomy / Q000379:methods*; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D017116:Low Back Pain / Q000453:epidemiology; D008159:Lumbar Vertebrae / Q000601:surgery; D008297:Male; D010147:Pain Measurement; D010149:Postoperative Pain / Q000453:epidemiology*; D017060:Patient Satisfaction; D011300:Preoperative Care / Q000379:methods; D011446:Prospective Studies; D011795:Surveys and Questionnaires; D013997:Time Factors
chemical_list: D005938:Glucocorticoids; D003907:Dexamethasone
keywords: Dexamethasone; Glucocorticoids; Persistent postoperative pain; Preemptive medicine; Spine surgery