title: Review of developmental origins of health and disease publications in environmental epidemiology.
abstract: The Developmental Origins of Health and Disease (DOHaD) scientific field investigates the influence of early life environmental stressors on later life health outcomes. Environmental chemical exposures are a particular focus area within this field. Although the DOHaD hypothesis originated in the 1990s, the data evaluating this hypothesis in environmental epidemiology has not been comprehensively summarized. We conducted a scoping literature review to describe the human evidence for the DOHaD hypothesis and to identify, 1) where there may be reasonable data to draw conclusions, and 2) areas warranting further research. Using PubMed and Web of Science we identified 425 publications through 2014 that met our criteria for evaluating the DOHaD hypothesis in environmental epidemiology. These publications covered 60 different chemicals. The majority of publications focused on neurological/cognitive outcomes, followed by cancer, and respiratory outcomes. We note areas ready for more detailed review, those requiring more data and ideas for future directions.
authors.affiliation: Division of Extramural Research and Training, National Institute of Environmental Health Sciences, RTP NC 27709, United States. Electronic address: heindelj@niehs.nih.gov.
authors.forename: Jerrold J
authors.initials: JJ
authors.lastname: Heindel
authors.affiliation: MDB Inc. Durham NC, United States.
authors.forename: Lesley A
authors.initials: LA
authors.lastname: Skalla
authors.affiliation: Division of Extramural Research and Training, National Institute of Environmental Health Sciences, RTP NC 27709, United States.
authors.forename: Bonnie R
authors.initials: BR
authors.lastname: Joubert
authors.affiliation: Division of Extramural Research and Training, National Institute of Environmental Health Sciences, RTP NC 27709, United States.
authors.forename: Caroline H
authors.initials: CH
authors.lastname: Dilworth
authors.affiliation: Division of Extramural Research and Training, National Institute of Environmental Health Sciences, RTP NC 27709, United States.
authors.forename: Kimberly A
authors.initials: KA
authors.lastname: Gray
mesh_terms: D000818:Animals; D004781:Environmental Exposure / Q000009:adverse effects*; D004785:Environmental Pollutants / Q000633:toxicity*; D016021:Epidemiologic Studies; D005260:Female; D006801:Humans; D018811:Maternal Exposure / Q000009:adverse effects*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000453:epidemiology* / Q000209:etiology
chemical_list: D004785:Environmental Pollutants
keywords: Birth cohorts; Developmental origins of health and disease (DOHaD); Early life exposures; Endocrine disruptors; Environmental exposures; Epidemiology