title: Skin lesion in a patient with acute myeloid leukemia.
abstract: We present the case of a 51-year-old man with acute myeloid leukemia who developed fevers with a skin lesion following the first cycle of induction chemotherapy. Skin biopsy showed evidence of invasive fungal infection. Cultures remained negative, but polymerase chain reaction on tissue detected Rhizopus oryzae complex. The patient was started on liposomal amphotericin B and underwent surgical debridement. He was switched to posaconazole, with plans for allogeneic hematopoetic stem cell transplant in the future.
authors.affiliation: Division of Infectious Diseases, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
authors.forename: Atul
authors.initials: A
authors.lastname: Kothari
authors.affiliation: Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
authors.forename: Sara C
authors.initials: SC
authors.lastname: Shalin
authors.affiliation: Division of Infectious Diseases, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
authors.forename: Juan Carlos Rico
authors.initials: JC
authors.lastname: Crescencio
authors.affiliation: Division of Infectious Diseases, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
authors.forename: Mary J
authors.initials: MJ
authors.lastname: Burgess
mesh_terms: D000666:Amphotericin B / Q000008:administration & dosage / Q000627:therapeutic use; D019072:Antibiotic Prophylaxis / Q000009:adverse effects; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001706:Biopsy; D003646:Debridement; D003881:Dermatomycoses / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D064147:Febrile Neutropenia / Q000188:drug therapy* / Q000209:etiology / Q000382:microbiology; D005542:Forearm; D006801:Humans; D016867:Immunocompromised Host; D060828:Induction Chemotherapy / Q000009:adverse effects / Q000379:methods; D000072742:Invasive Fungal Infections / Q000382:microbiology / Q000473:pathology / Q000628:therapy*; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009091:Mucormycosis / Q000150:complications / Q000382:microbiology / Q000473:pathology / Q000628:therapy*; D016133:Polymerase Chain Reaction; D012331:RNA, Fungal / Q000302:isolation & purification*; D012233:Rhizopus / Q000302:isolation & purification*; D014230:Triazoles / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D000935:Antifungal Agents; D012331:RNA, Fungal; D014230:Triazoles; C068538:liposomal amphotericin B; C101425:posaconazole; D000666:Amphotericin B
keywords: acute myeloid leukemia; mucormycosis; skin lesion