title: Run-and-pause dynamics of cytoskeletal motor proteins.
abstract: Cytoskeletal motor proteins are involved in major intracellular transport processes which are vital for maintaining appropriate cellular function. When attached to cytoskeletal filaments, the motor exhibits distinct states of motility: active motion along the filaments, and pause phase in which it remains stationary for a finite time interval. The transition probabilities between motion and pause phases are asymmetric in general, and considerably affected by changes in environmental conditions which influences the efficiency of cargo delivery to specific targets. By considering the motion of individual non-interacting molecular motors on a single filament as well as a dynamic filamentous network, we present an analytical model for the dynamics of self-propelled particles which undergo frequent pause phases. The interplay between motor processivity, structural properties of filamentous network, and transition probabilities between the two states of motility drastically changes the dynamics: multiple transitions between different types of anomalous diffusive dynamics occur and the crossover time to the asymptotic diffusive or ballistic motion varies by several orders of magnitude. We map out the phase diagrams in the space of transition probabilities, and address the role of initial conditions of motion on the resulting dynamics.
authors.affiliation: Department of Theoretical Physics, Saarland University, 66041 Saarbrücken, Germany.
authors.forename: Anne E
authors.initials: AE
authors.lastname: Hafner
authors.affiliation: Department of Theoretical Physics, Saarland University, 66041 Saarbrücken, Germany.
authors.forename: Ludger
authors.initials: L
authors.lastname: Santen
authors.affiliation: Department of Theoretical Physics, Saarland University, 66041 Saarbrücken, Germany.
authors.forename: Heiko
authors.initials: H
authors.lastname: Rieger
authors.affiliation: Department of Theoretical Physics, Saarland University, 66041 Saarbrücken, Germany.
authors.forename: M Reza
authors.initials: MR
authors.lastname: Shaebani
mesh_terms: D003598:Cytoskeletal Proteins / Q000737:chemistry* / Q000378:metabolism; D008956:Models, Chemical; D056004:Molecular Dynamics Simulation; D020409:Molecular Motor Proteins / Q000737:chemistry* / Q000378:metabolism
chemical_list: D003598:Cytoskeletal Proteins; D020409:Molecular Motor Proteins