title: Challenges in the use of immunotherapy in metastatic melanoma.
abstract: A 65-year-old man with metastatic melanoma was started on immunotherapy, switched to alternative targeted therapy and developed disseminated intravascular coagulation. This case underscores the complexity of interpreting and managing side effects of novel therapies in cancer care, identification of progression versus pseudoprogression and challenges in sequencing treatments in metastatic melanoma.
authors.affiliation: Boston Medical Center, Boston, Massachusetts, USA.
authors.forename: Ashley
authors.initials: A
authors.lastname: Tran
authors.affiliation: Section of Hematology Oncology, Boston University School of Medicine, Boston, Massachusetts, USA.
authors.forename: Shayna
authors.initials: S
authors.lastname: Sarosiek
authors.affiliation: Section of Hematology Oncology, Boston University School of Medicine, Boston, Massachusetts, USA.
authors.forename: Naomi Y
authors.identifier: http://orcid.org/0000-0001-9689-9601
authors.initials: NY
authors.lastname: Ko
mesh_terms: D000368:Aged; D018450:Disease Progression; D004211:Disseminated Intravascular Coagulation / Q000209:etiology*; D006801:Humans; D007167:Immunotherapy / Q000009:adverse effects*; D008297:Male; D008545:Melanoma / Q000473:pathology / Q000628:therapy*