title: Analysis of morphine responses in mice reveals a QTL on Chromosome 7.
abstract: In this study we identified a quantitative trait locus (QTL) on mouse Chromosome 7 associated with locomotor activity and rearing post morphine treatment. This QTL was revealed after correcting for the effects of another QTL peak on Chromosome 10 using composite interval mapping. The positional candidate genes areSyt9andPpfibp2. Several other genes within the interval are linked to neural processes, locomotor activity, and the defensive response to harmful stimuli.
authors.affiliation: Institut de Neurosciences Cognitives et Intégratives d'Aquitaine, UMR 5287, University of Bordeaux, Pessac cedex, France; Institut de Neurosciences Cognitives et Intégratives d'Aquitaine, UMR 5287, CNRS, Pessac, France.
authors.forename: Wim E
authors.initials: WE
authors.lastname: Crusio
authors.affiliation: Lambert High School, Suwanee, USA; BioScience Project, Wakefield, USA.
authors.forename: Esha
authors.initials: E
authors.lastname: Dhawan
authors.affiliation: Jackson Laboratory, Bar Harbor, USA.
authors.forename: Elissa J
authors.initials: EJ
authors.lastname: Chesler
authors.affiliation: BioScience Project, Wakefield, USA.
authors.forename: Anna
authors.initials: A
authors.lastname: Delprato
keywords: Locomotor activity; Opioids; QTL analysis; Reward pathway