title: Lineage mapper: A versatile cell and particle tracker.
abstract: The ability to accurately track cells and particles from images is critical to many biomedical problems. To address this, we developed Lineage Mapper, an open-source tracker for time-lapse images of biological cells, colonies, and particles. Lineage Mapper tracks objects independently of the segmentation method, detects mitosis in confluence, separates cell clumps mistakenly segmented as a single cell, provides accuracy and scalability even on terabyte-sized datasets, and creates division and/or fusion lineages. Lineage Mapper has been tested and validated on multiple biological and simulated problems. The software is available in ImageJ and Matlab at isg.nist.gov.
authors.affiliation: Information Technology Laboratory, National Institute of Standards and Technology, 100 Bureau Drive, Gaithersburg MD, 20899, USA.
authors.forename: Joe
authors.initials: J
authors.lastname: Chalfoun
authors.affiliation: Information Technology Laboratory, National Institute of Standards and Technology, 100 Bureau Drive, Gaithersburg MD, 20899, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Majurski
authors.affiliation: Information Technology Laboratory, National Institute of Standards and Technology, 100 Bureau Drive, Gaithersburg MD, 20899, USA.
authors.forename: Alden
authors.initials: A
authors.lastname: Dima
authors.affiliation: Materials Measurement Laboratory, National Institute of Standards and Technology, 100 Bureau Drive, Gaithersburg MD, 20899, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Halter
authors.affiliation: Physical Measurement Laboratory, National Institute of Standards and Technology, 100 Bureau Drive, Gaithersburg MD, 20899, USA.|Fischell Department of Bioengineering, University of Maryland at College Park, College Park, MD, 20742, USA.
authors.forename: Kiran
authors.initials: K
authors.lastname: Bhadriraju
authors.affiliation: Information Technology Laboratory, National Institute of Standards and Technology, 100 Bureau Drive, Gaithersburg MD, 20899, USA.
authors.forename: Mary
authors.initials: M
authors.lastname: Brady
mesh_terms: D019070:Cell Lineage / Q000502:physiology*; D007091:Image Processing, Computer-Assisted; D008938:Mitosis / Q000502:physiology*; D012984:Software