title: Addition of cranberry to proton pump inhibitor-based triple therapy forHelicobacter pylorieradication.
abstract: OBJECTIVE
  Proton pump inhibitor-based triple therapy with two antibiotics forHelicobacter pylorieradication is widely accepted, but this combination fails in a considerable number of cases. Some studies have shown that cranberry inhibits the adhesion of a wide range of microbial pathogens, includingH. pylori. The aim of this study was to assess the effect of cranberry onH. pylorieradication with a standard therapy including lansoprazole, clarithromycin, and amoxicillin (LCA) in patients with peptic ulcer disease (PUD).
  
  
  METHODS
  In this study,H. pylori-positive patients with PUD were randomized into two groups: Group A: A 14-day LCA triple therapy with 30 mg lansoprazole bid, 1000 mg amoxicillin bid, and 500 mg clarithromycin bid; Group B: A 14-day 500 mg cranberry capsules bid plus LCA triple therapy. A13C-urea breath test was performed for eradication assessment 6 weeks after the completion of the treatment.
  
  
  RESULTS
  Two hundred patients (53.5% males, between 23 and 77 years, mean age ± standard deviation: 50.29 ± 17.79 years) continued treatment protocols and underwent13C-urea breath testing.H. pylorieradication was achieved in 74% in Group A (LCA without cranberry) and 89% in Group B (LCA with cranberry) (P= 0.042).
  
  
  CONCLUSIONS
  The addition of cranberry to LCA triple therapy forH. pylorihas a higher rate of eradication than the standard regimen alone (up to 89% and significant).
authors.affiliation: Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Golestan Province, Iran.
authors.forename: Mohammadreza
authors.initials: M
authors.lastname: Seyyedmajidi
authors.affiliation: Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Golestan Province, Iran.
authors.forename: Anahita
authors.initials: A
authors.lastname: Ahmadi
authors.affiliation: Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Golestan Province, Iran.
authors.forename: Shahin
authors.initials: S
authors.lastname: Hajiebrahimi
authors.affiliation: Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Golestan Province, Iran.
authors.forename: Seyedali
authors.initials: S
authors.lastname: Seyedmajidi
authors.affiliation: Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Golestan Province, Iran.
authors.forename: Majid
authors.initials: M
authors.lastname: Rajabikashani
authors.affiliation: Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Golestan Province, Iran.
authors.forename: Mona
authors.initials: M
authors.lastname: Firoozabadi
authors.affiliation: Qom Gastroenterology and Hepatology Research Center, Qom University of Medical Sciences, Qom, Iran; Gastrointestinal and Liver Diseases Research Center, Iran University of Medical Sciences, Tehran, Iran.
authors.forename: Jamshid
authors.initials: J
authors.lastname: Vafaeimanesh
keywords: Cranberry; Helicobacter pylori; eradication therapy