title: Role of ursodeoxycholic acid in the prevention of gallstone formation after laparoscopic sleeve gastrectomy.
abstract: OBJECTIVE
  Postoperative cholelithiasis (CL) is a latent complication of bariatric surgery. The aim of this study was to evaluate the role of ursodeoxycholic acid (UDCA) in the prevention of CL after laparoscopic sleeve gastrectomy (LSG).
  
  
  METHODS
  This was a retrospective analysis of the prospectively collected data of patients with morbid obesity who underwent LSG. Patients were subdivided into two groups: Group I, which did not receive prophylactic treatment with UCDA after LSG; and Group II, which received UCDA therapy for 6 months after LSG. Patients' characteristics, operation duration, weight loss data, and incidence of CL at 6 and 12 months postoperatively were collected.
  
  
  RESULTS
  A total of 406 patients (124 males, 282 females) with a mean age of 32.1 ± 9.4 years were included. The mean baseline body mass index (BMI) was 50.1 ± 8.3 kg/m2. Group I comprised 159 patients, and Group II comprised 247 patients. The two groups showed comparable demographics, % excess weight loss (EWL), and decrease in BMI at 6 and 12 months after LSG. Eight patients (5%) developed CL in Group I, whereas no patients in Group II did (P = 0.0005). Preoperative dyslipidemia and rapid loss of excess weight within the first 3 months after LSG were the risk factors that significantly predicted CL postoperatively.
  
  
  CONCLUSIONS
  The use of UCDA effectively reduced the incidence of CL after LSG in patients with morbid obesity. Dyslipidemia and rapid EWL in the first 3 months after LSG significantly predisposed patients to postoperative CL.
authors.affiliation: General Surgery Department, Mansoura Faculty of Medicine, Mansoura University Hospitals, Elgomhuoria Street, Mansoura, Egypt.
authors.forename: Emad
authors.initials: E
authors.lastname: Abdallah
authors.affiliation: General Surgery Department, Mansoura Faculty of Medicine, Mansoura University Hospitals, Elgomhuoria Street, Mansoura, Egypt. Sameh200@hotmail.com.
authors.forename: Sameh Hany
authors.initials: SH
authors.lastname: Emile
authors.affiliation: General Surgery Department, Mansoura Faculty of Medicine, Mansoura University Hospitals, Elgomhuoria Street, Mansoura, Egypt.
authors.forename: Hossam
authors.initials: H
authors.lastname: Elfeki
authors.affiliation: General Surgery Department, Mansoura Faculty of Medicine, Mansoura University Hospitals, Elgomhuoria Street, Mansoura, Egypt.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Fikry
authors.affiliation: General Surgery Department, Mansoura Faculty of Medicine, Mansoura University Hospitals, Elgomhuoria Street, Mansoura, Egypt.
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Abdelshafy
authors.affiliation: General Surgery Department, Mansoura Faculty of Medicine, Mansoura University Hospitals, Elgomhuoria Street, Mansoura, Egypt.
authors.forename: Ayman
authors.initials: A
authors.lastname: Elshobaky
authors.affiliation: General Surgery Department, Mansoura Faculty of Medicine, Mansoura University Hospitals, Elgomhuoria Street, Mansoura, Egypt.
authors.forename: Hesham
authors.initials: H
authors.lastname: Elgendy
authors.affiliation: General Surgery Department, Mansoura Faculty of Medicine, Mansoura University Hospitals, Elgomhuoria Street, Mansoura, Egypt.
authors.forename: Waleed
authors.initials: W
authors.lastname: Thabet
authors.affiliation: General Surgery Department, Mansoura Faculty of Medicine, Mansoura University Hospitals, Elgomhuoria Street, Mansoura, Egypt.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Youssef
authors.affiliation: General Surgery Department, Mansoura Faculty of Medicine, Mansoura University Hospitals, Elgomhuoria Street, Mansoura, Egypt.
authors.forename: Hosam
authors.initials: H
authors.lastname: Elghadban
authors.affiliation: General Surgery Department, Mansoura Faculty of Medicine, Mansoura University Hospitals, Elgomhuoria Street, Mansoura, Egypt.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Lotfy
mesh_terms: D000328:Adult; D050110:Bariatric Surgery / Q000379:methods*; D002769:Cholelithiasis / Q000517:prevention & control*; D005260:Female; D005743:Gastrectomy / Q000379:methods*; D006801:Humans; D010535:Laparoscopy / Q000379:methods*; D008297:Male; D009767:Obesity, Morbid / Q000601:surgery*; D011183:Postoperative Complications / Q000517:prevention & control*; D012189:Retrospective Studies; D012307:Risk Factors; D014580:Ursodeoxycholic Acid / Q000008:administration & dosage*; D055815:Young Adult
chemical_list: D014580:Ursodeoxycholic Acid
keywords: Cholelithiasis; Gallstones formation; Morbid obesity; Sleeve gastrectomy; UCDA; Ursodeoxycholic acid