title: Eukaryotic Ribosome as a Target for Cardiovascular Disease.
abstract: Cardiovascular diseases have been associated with genetic variants and increased plasma level of the secreted protein PCSK9. In this issue of Cell Chemical Biology, Petersen et al. (2016) describe an inhibitor of PCSK9 secretion in human cells that, surprisingly, targets the 80S ribosome.
authors.affiliation: Department of Integrated Structural Biology, Institute of Genetics and Molecular and Cellular Biology, 1 rue Laurent Fries, BP 10142, Illkirch 67404, France; Centre National de Recherche Scientifique (CNRS) UMR 7104, Illkirch 67404, France; Institut National de Santé et de Recherche Médicale (INSERM) U964, Illkirch 67404, France; Université de Strasbourg, Strasbourg 67081, France.
authors.forename: Simone
authors.initials: S
authors.lastname: Pellegrino
authors.affiliation: Department of Integrated Structural Biology, Institute of Genetics and Molecular and Cellular Biology, 1 rue Laurent Fries, BP 10142, Illkirch 67404, France; Centre National de Recherche Scientifique (CNRS) UMR 7104, Illkirch 67404, France; Institut National de Santé et de Recherche Médicale (INSERM) U964, Illkirch 67404, France; Université de Strasbourg, Strasbourg 67081, France. Electronic address: gula@igbmc.fr.
authors.forename: Gulnara
authors.initials: G
authors.lastname: Yusupova
mesh_terms: D002318:Cardiovascular Diseases; D056890:Eukaryota; D006801:Humans; D000071449:Proprotein Convertase 9; D014176:Protein Biosynthesis; D012270:Ribosomes; D000078604:Secretagogues
chemical_list: D000078604:Secretagogues; C472125:PCSK9 protein, human; D000071449:Proprotein Convertase 9