title: Evaluation of the in vivo anti-inflammatory activity of a flavone glycoside from Cancrinia discoidea (Ledeb.) Poljak.
abstract: The anti-inflammatory effect of selagin-7-O-(6″-O-Acetyl-)-β-D-glucoside, isolated from the medicinal herbCancrinia discoidea(Ledeb.) Poljak, was evaluated for its anti-inflammatory activity in the carrageenin- and serotonin-induced rat paw oedema models of acute inflammation and the cotton pellet-induced granuloma rat model of chronic inflammation. Flavone glycoside at doses of 5, 10, or 20 mg/kg, the clinical anti-inflammatory indomethacin at 10 mg/kg, or vehicle were administered orally before injection of the pro-inflammatory compound. The test compound showed significant anti-inflammatory activity against paw edema induced by carrageenin or serotonin, most notably at the highest test dose of 20 mg/kg. In the cotton pellet-induced granuloma model, the compound showed dose-dependent anti-inflammatory activity, with the highest effect at 20 mg/kg. In all three assays, the flavone glucoside compound was more active at 20 mg/kg than indomethacin at 10 mg/kg.
authors.affiliation: College of Food and Bioengineering, South China University of Technology, Wushan Road 381, Guangzhou 510641, China.
authors.forename: Jian-Yu
authors.initials: JY
authors.lastname: Su
authors.affiliation: College of Food and Bioengineering, South China University of Technology, Wushan Road 381, Guangzhou 510641, China.
authors.forename: Qing-Chan
authors.initials: QC
authors.lastname: Li
authors.affiliation: College of Food and Bioengineering, South China University of Technology, Wushan Road 381, Guangzhou 510641, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Zhu
keywords: Cancrinia discoidea (Ledeb.) Poljak; anti-inflammatory activity; selagin-7-O-(6"-O-Acetyl-)-beta-D-glucoside