title: Successful improvement of Buschke-Löwenstein tumour in an HIV-infected patient with antiretroviral therapy alone.
abstract: Buschke-Löwenstein tumour (BLT), also defined as giant condyloma acuminatum, is a rare exophytic tumour affecting the anogenital and perianal regions associated with human papillomavirus (HPV) infections, with a potential of malignant transformation and which is at a greater risk in T-cell mediated immunodeficient patients. Different therapeutic options, alone or in combination, have been reported for the treatment of BLT including local therapy but wide surgical local excision is however recommended as the most important therapeutic intervention. We report a case of a HIV-infected man who developed a voluminous pelvic BLT which disappeared progressively under antiretroviral therapy with no additional treatment, contemporary to an improvement of his immunity, highlighting the possible spontaneous reversibility of HPV-induced tumours in treated HIV infection.
authors.affiliation: Hopitaux Universitaires Henri Mondor, Creteil, France.
authors.forename: Camille
authors.initials: C
authors.lastname: Grodner
authors.affiliation: Hopitaux Universitaires Henri Mondor, Creteil, France.|Universite Paris-Est Creteil Val de Marne Faculte de medecine, Creteil, France.
authors.forename: Aurélia
authors.initials: A
authors.lastname: Henn
authors.affiliation: Hopitaux Universitaires Henri Mondor, Creteil, France.|Universite Paris-Est Creteil Val de Marne Faculte de medecine, Creteil, France.
authors.forename: Jean-Daniel
authors.initials: JD
authors.lastname: Lelièvre
authors.affiliation: Hopitaux Universitaires Henri Mondor, Creteil, France.|Universite Paris-Est Creteil Val de Marne Faculte de medecine, Creteil, France.
authors.forename: Sébastien
authors.identifier: http://orcid.org/0000-0002-8033-0936
authors.initials: S
authors.lastname: Gallien
mesh_terms: D044966:Anti-Retroviral Agents / Q000627:therapeutic use*; D062688:Buschke-Lowenstein Tumor / Q000188:drug therapy* / Q000473:pathology; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D027383:Papillomaviridae; D010386:Pelvic Neoplasms / Q000188:drug therapy* / Q000473:pathology
chemical_list: D044966:Anti-Retroviral Agents