title: Transmission of chromosomally integrated human herpesvirus 6 via cord blood transplantation.
abstract: Chromosomally integrated human herpesvirus 6 (ciHHV-6) can be transmitted via allogeneic hematopoietic cell transplantation. To date, only a few cases have been reported. Here, we report a case identified as transmission of ciHHV-6 via cord blood transplantation. Distinguishing transmission of ciHHV-6 from HHV-6 reactivation in cases with high titer of HHV-6 DNA load after transplantation is important to prevent unnecessary exposure to antiviral drugs that could be toxic.
authors.affiliation: Children's Cancer Center, National Center for Child Health and Development, Tokyo, Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Yamada
authors.affiliation: Children's Cancer Center, National Center for Child Health and Development, Tokyo, Japan.
authors.forename: Tomoo
authors.initials: T
authors.lastname: Osumi
authors.affiliation: Division of Advanced Medicine for Virus Infections, National Research Institute for Child Health and Development, Tokyo, Japan.
authors.forename: Ken-Ichi
authors.initials: KI
authors.lastname: Imadome
authors.affiliation: Division of Advanced Medicine for Virus Infections, National Research Institute for Child Health and Development, Tokyo, Japan.
authors.forename: Etsuko
authors.initials: E
authors.lastname: Takahashi
authors.affiliation: Department of Molecular Laboratory Medicine, Faculty of Medical Technology, School of Health Sciences, Fujita Health University, Toyoake, Japan.
authors.forename: Tamae
authors.initials: T
authors.lastname: Ohye
authors.affiliation: Department of Pediatrics, Fujita Health University, Toyoake, Japan.
authors.forename: Tetsushi
authors.initials: T
authors.lastname: Yoshikawa
authors.affiliation: Children's Cancer Center, National Center for Child Health and Development, Tokyo, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Tomizawa
authors.affiliation: Children's Cancer Center, National Center for Child Health and Development, Tokyo, Japan.
authors.forename: Motohiro
authors.initials: M
authors.lastname: Kato
authors.affiliation: Children's Cancer Center, National Center for Child Health and Development, Tokyo, Japan.
authors.forename: Kimikazu
authors.initials: K
authors.lastname: Matsumoto
mesh_terms: D000212:Acyclovir / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000627:therapeutic use; D019072:Antibiotic Prophylaxis; D000998:Antiviral Agents / Q000008:administration & dosage / Q000627:therapeutic use; D002066:Busulfan / Q000009:adverse effects / Q000627:therapeutic use; D002675:Child, Preschool; D002892:Chromosomes, Human, Pair 22 / Q000821:virology*; D036101:Cord Blood Stem Cell Transplantation / Q000009:adverse effects*; D004279:DNA, Viral / Q000302:isolation & purification; D005076:Exanthema / Q000097:blood / Q000821:virology; D005312:Fetal Blood / Q000821:virology*; D005334:Fever / Q000097:blood / Q000821:virology; D015654:Herpesvirus 6, Human / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D016867:Immunocompromised Host; D008297:Male; D008558:Melphalan / Q000009:adverse effects / Q000627:therapeutic use; D019653:Myeloablative Agonists / Q000009:adverse effects* / Q000627:therapeutic use; D019349:Roseolovirus Infections / Q000097:blood / Q000235:genetics / Q000635:transmission* / Q000821:virology; D019172:Transplantation Conditioning / Q000009:adverse effects*; D061349:Unrelated Donors; D000077483:Valacyclovir; D014633:Valine / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000627:therapeutic use; D019562:Viral Load; D016662:Virus Integration
chemical_list: D000998:Antiviral Agents; D004279:DNA, Viral; D019653:Myeloablative Agonists; D002066:Busulfan; D014633:Valine; D000077483:Valacyclovir; D008558:Melphalan; D000212:Acyclovir
keywords: chromosomally integrated HHV-6; cord blood transplantation; hematopoietic cell transplantation; human herpesvirus 6 (HHV-6); real-time quantitative polymerase chain reaction