title: Cloning and expression analysis of a novel tissue-specific dopa decarboxylase mRNA splicing variant in Bombyx mori.
abstract: Dopa decarboxylase (DDC) protein is involved in the synthesis of dopamine and serotonin. Here, we show that in the silkworm Bombyx mori, a novel DDC splicing variant is selectively expressed in the brain and subesophageal ganglia. In Drosophila melanogaster, a neuron-specific isoform of DDC is known to be alternatively spliced in a similar manner.
authors.affiliation: a Faculty of Science, Department of Biological Sciences , Kanagawa University , Hiratsuka , Japan.|b Department of Integrated Biosciences , Graduate School of Frontier Sciences, The University of Tokyo , Kashiwa , Japan.
authors.forename: Dai
authors.initials: D
authors.lastname: Tsukioka
authors.affiliation: a Faculty of Science, Department of Biological Sciences , Kanagawa University , Hiratsuka , Japan.
authors.forename: Susumu
authors.initials: S
authors.lastname: Izumi
authors.affiliation: a Faculty of Science, Department of Biological Sciences , Kanagawa University , Hiratsuka , Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Adachi
mesh_terms: D020121:5' Untranslated Regions; D017398:Alternative Splicing; D000818:Animals; D012831:Bombyx / Q000235:genetics*; D001921:Brain / Q000201:enzymology; D003001:Cloning, Molecular; D004296:Dopa Decarboxylase / Q000235:genetics* / Q000378:metabolism; D017952:Ganglia, Invertebrate / Q000201:enzymology; D015971:Gene Expression Regulation, Enzymologic; D019476:Insect Proteins / Q000235:genetics* / Q000378:metabolism; D009928:Organ Specificity; D020033:Protein Isoforms / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics
chemical_list: D020121:5' Untranslated Regions; D019476:Insect Proteins; D020033:Protein Isoforms; D012333:RNA, Messenger; D004296:Dopa Decarboxylase
keywords: Bombyx mori; alternative splicing; dopa decarboxylase