title: Nuclear subcompartments: an overview.
abstract: The advance in biochemical and microscopy techniques has revealed the complexity and intricate nucleoplasm structure. Several subcompartments were identified in nucleus and the importance of these subcompartments in processes crucial for normal nuclear activity has been demonstrated. In this mini-review, we will give an overview about the composition, function, and importance of the major nuclear subcompartments. Also, we will show the impact that perturbing these structures can cause in normal nuclear activity, and how these can contribute to the development of some human diseases.
authors.affiliation: Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de Sao Paulo, Sao Paulo, Brazil.|Departamento de Medicina, Faculdade Multivix, Vitória, Espirito Santo, Brazil.
authors.forename: Vinícius Santana
authors.initials: VS
authors.lastname: Nunes
authors.affiliation: Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de Sao Paulo, Sao Paulo, Brazil.
authors.forename: Nilmar Silvio
authors.initials: NS
authors.lastname: Moretti
mesh_terms: D000818:Animals; D002453:Cell Cycle; D002467:Cell Nucleus / Q000378:metabolism*; D004194:Disease; D006801:Humans; D012313:RNA / Q000378:metabolism; D012261:Ribonucleoproteins / Q000096:biosynthesis; D013347:Subcellular Fractions / Q000378:metabolism
chemical_list: D012261:Ribonucleoproteins; D012313:RNA
keywords: Cajal bodies; PML bodies; nuclear bodies; nucleolus; speckles; spinal muscular atrophy