title: Effect of peritoneal dialysis versus hemodialysis on renal anemia in renal in end-stage disease patients: a meta-analysis.
abstract: The aim of this meta-analysis was to evaluate the effect of peritoneal dialysis (PD) and hemodialysis (HD) on renal anemia (RA) in renal disease patients by a meta-analysis. Relevant studies published before June 2015 were searched. Pooled odds ratio (OR) with 95% confidence interval (CI) was used to evaluate the effect of HD and PD on RA based on five indexes: hemoglobin, ferritin, transferrin saturation index, serum albumin, and parathyroid hormone. Sensitivity analysis and publication bias assessment were conducted to evaluate the stability and reliability of our results. A total of fourteen eligible studies with 1103 cases underwent HD and 625 cases underwent PD were used for this meta-analysis. There were no significant difference for levels of hemoglobin (SMD = -0.23, 95% CI: -0.74 to 0.28), ferritin (SMD = 0.01, 95% CI: -0.59 to 0.62), parathyroid hormone (SMD = 0.11, 95% CI: -1.53 to 1.75) and transferrin saturation index (SMD = -0.06, 95% CI: -0.67 to 0.56) between HD and PD group. However, the content of serum albumin in HD group was much more than that in PD group (SMD = 1.58, 95% CI: 0.35 to 2.81). Neither of the included studies could reverse the pooled side effect and Egger's test demonstrated no publication bias. Both of the two dialysis strategies have a similar effect on RA in renal disease patients.
authors.affiliation: a Department of Nephrology , The First Hospital of Jilin University , Jilin Province , China.
authors.forename: Wan-Ning
authors.initials: WN
authors.lastname: Wang
authors.affiliation: b Department of Hematology and Oncology , China-Japan Union Hospital of Jilin University , Jilin Province , China.
authors.forename: Wen-Long
authors.initials: WL
authors.lastname: Zhang
authors.affiliation: a Department of Nephrology , The First Hospital of Jilin University , Jilin Province , China.
authors.forename: Tao
authors.initials: T
authors.lastname: Sun
authors.affiliation: a Department of Nephrology , The First Hospital of Jilin University , Jilin Province , China.
authors.forename: Fu-Zhe
authors.initials: FZ
authors.lastname: Ma
authors.affiliation: a Department of Nephrology , The First Hospital of Jilin University , Jilin Province , China.
authors.forename: Sensen
authors.initials: S
authors.lastname: Su
authors.affiliation: a Department of Nephrology , The First Hospital of Jilin University , Jilin Province , China.
authors.forename: Zhong-Gao
authors.initials: ZG
authors.lastname: Xu
mesh_terms: D000740:Anemia / Q000097:blood / Q000453:epidemiology*; D005293:Ferritins / Q000097:blood; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000628:therapy*; D010281:Parathyroid Hormone / Q000097:blood; D010530:Peritoneal Dialysis; D016032:Randomized Controlled Trials as Topic; D006435:Renal Dialysis; D012709:Serum Albumin / Q000032:analysis
chemical_list: D006454:Hemoglobins; D010281:Parathyroid Hormone; D012709:Serum Albumin; D005293:Ferritins
keywords: Peritoneal dialysis; hemodialysis; meta-analysis; renal anemia; renal in end-stage