title: [Distribution and compensation mechanism of aberrations between anterior and posterior surface of the cornea in myopia and myopic astigmatism eyes].
abstract: Objective:To study the compensation mechanism of aberrations between anterior and posterior corneal surface, and to investigate the correlations between corneal aberrations and K values, intraocular pressure and central corneal thickness.Methods:One hundred and sixty-one subjects (300 eyes) with myopia and myopic astigmatism were recruited randomly. Corneal aberrations (anterior, posterior and total) in three different optical zones (2 mm, 4 mm, and 6 mm) centered on the corneal vertex were assessed with a corneal topographer (Sirius). We also calculated compensation factors (CFs) as a measure of the relative efficiency of the aberration compensation mechanism. Astigmatism was divided into corneal astigmatism and non-corneal astigmatism. Mann-WhitneyUtest was utilized for the comparison of different aberrations and CFs between the two astigmatism groups. Spearman correlation was applied to analyze the correlations between corneal aberrations and K values, intraocular pressure and central corneal thickness.Results:As the order of the aberrations elevated from the second to the seventh, the RMS values decreased significantly. The larger the optical zone, the greater the values of aberrations and the lower the percentage of the compensation mechanism among all the Zernike terms. At the same time, as the order of the aberrations increased, the predominance of the compensation mechanism was increasingly obvious. Slight compensation of spherical aberration (Z40) was observed in the peripheral. In the center of the analyzing zones (2 mm), compensation mechanism represented in coma (Z3±1), and it disappeared in the peripheral. We detected slight compensation of the corneal astigmatism (Z2±2) in the surrounding zone, although the compensation factors were closed to zero in diverse optical zones. Superposition was found in trefoil (Z3±3) straightly. Nevertheless, a tendency towards compensation was discovered with the enlargement of the optical zones. And the secondary spherical aberration (Z60) behaved compensation continuously. However, similar compensation was discovered between the right eye and left eye in different analyzing optical zones. There were significant correlations between the flattest K values and Z2±2, Z3±3and Z40in the anterior, posterior and total cornea. It was similar with the steepest K values. When the optical zone expanded to 6 mm, Z3±1and Z40significantly decreased with intraocular pressure (rcoma=-0.188,P<0.05.rspherical=-0.147,P<0.05). No correlation was found between various aberrations and central corneal thickness (P>0.05).Conclusions:Compensation dominated in the corneal center, while the percentage decreased gradually as the optical zone extended. Slight compensation in astigmatism and spherical aberration between the anterior and posterior cornea may be benificial to the scotopic visual quality. Corneal aberrations were significantly related to K values and intraocular pressure.(Chin J Ophthalmol, 2016, 52: 840-849).
authors.affiliation: Clinical College of Ophthalmology Tianjin Medical University, Tianjin Eye Hospital, Tianjin Key Lab. of Ophthalmology and Visual Science, Tianjin Eye Institute, Tianjin 300020, China.
authors.forename: X J
authors.initials: XJ
authors.lastname: Li
authors.forename: Y
authors.initials: Y
authors.lastname: Wang
authors.forename: Y N
authors.initials: YN
authors.lastname: Wu
authors.forename: W J
authors.initials: WJ
authors.lastname: Wu
authors.forename: C J
authors.initials: CJ
authors.lastname: Yu
authors.forename: L L
authors.initials: LL
authors.lastname: Xu
mesh_terms: D000328:Adult; D001251:Astigmatism / Q000145:classification / Q000473:pathology / Q000503:physiopathology*; D003315:Cornea / Q000473:pathology / Q000503:physiopathology*; D019781:Corneal Topography; D005260:Female; D005654:Fundus Oculi; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D009216:Myopia / Q000473:pathology / Q000503:physiopathology*; D018709:Statistics, Nonparametric; D014065:Tonometry, Ocular