title: Platelet-rich fibrin may reduce the risk of delayed recovery in tooth-extracted patients undergoing oral bisphosphonate therapy: a trial study.
abstract: OBJECTIVE
  The aim of the present study was to evaluate the effectiveness of platelet-rich fibrin (PRF) as a wound-healing accelerator in patients undergoing oral bisphosphonate therapy and requiring tooth extractions.
  
  
  METHODS
  A total of 102 patients were divided into a PRF group and control group. The patients received oral bisphosphonate therapy for osteoporosis for an average of 32 months. Blood was collected and PRF was introduced into the socket of the PRF group only. Monitoring of mucosal healing was conducted for 3 months in both groups, and radiographic evaluation in the sockets was performed in the PRF group. Delayed recovery was defined as exposed bone and vulnerable granulation tissue without epithelization after 4 weeks and resolving by 8 weeks.
  
  
  RESULTS
  There were no intraoperative complications, and none of the patients exhibited onset of medication-related osteonecrosis of the jaw (MRONJ). Delayed recovery was observed in 9 out of 73 control patients (12%), whereas 29 PRF patients exhibited complete epithelialization of the socket within 1 month. The prevalence of delayed recovery was significantly higher in the control group than the PRF group (P < 0.05). Multivariate logistic regression analysis revealed that risk factors and use of PRF were independent significant factors to relate to delayed recovery (P = 0.02).
  
  
  CONCLUSIONS
  Early epithelization was confirmed in all PRF patients. Thus, PRF may reduce the risk of delayed recovery in patients undergoing oral bisphosphonate therapy.
  
  
  CONCLUSIONS
  PRF may be useful in preventing MRONJ in patients receiving oral bisphosphonate (BP).
authors.affiliation: Department of Oral Diagnosis and Medicine, Graduate School of Dental Medicine, Hokkaido University, Kita-13 Nishi-7 Kita-ku, Sapporo, Hokkaido, 060-8586, Japan. asakatakuya@den.hokudai.ac.jp.
authors.forename: Takuya
authors.identifier: http://orcid.org/0000-0001-8240-3441
authors.initials: T
authors.lastname: Asaka
authors.affiliation: Department of Oral Diagnosis and Medicine, Graduate School of Dental Medicine, Hokkaido University, Kita-13 Nishi-7 Kita-ku, Sapporo, Hokkaido, 060-8586, Japan.
authors.forename: Noritaka
authors.initials: N
authors.lastname: Ohga
authors.affiliation: Department of Gerodontology, Hokkaido University Graduate School of Dental Medicine, Sapporo, Japan.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Yamazaki
authors.affiliation: Department of Oral Diagnosis and Medicine, Graduate School of Dental Medicine, Hokkaido University, Kita-13 Nishi-7 Kita-ku, Sapporo, Hokkaido, 060-8586, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Sato
authors.affiliation: Department of Oral Diagnosis and Medicine, Graduate School of Dental Medicine, Hokkaido University, Kita-13 Nishi-7 Kita-ku, Sapporo, Hokkaido, 060-8586, Japan.
authors.forename: Chiharu
authors.initials: C
authors.lastname: Satoh
authors.affiliation: Department of Oral Diagnosis and Medicine, Graduate School of Dental Medicine, Hokkaido University, Kita-13 Nishi-7 Kita-ku, Sapporo, Hokkaido, 060-8586, Japan.
authors.forename: Yoshimasa
authors.initials: Y
authors.lastname: Kitagawa
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D050071:Bone Density Conservation Agents / Q000008:administration & dosage*; D004164:Diphosphonates / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000188:drug therapy*; D000073183:Platelet-Rich Fibrin / Q000502:physiology*; D014081:Tooth Extraction; D016896:Treatment Outcome; D014945:Wound Healing / Q000502:physiology*
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates
keywords: Epithelization; MRONJ; Oral bisphosphonates; PRF; Tooth extraction