title: The Prevalence of High-Risk HPV Types and Factors Determining Infection in Female Colombian Adolescents.
abstract: This study reports six HR-HPV types' infection prevalence discriminated by species and multiple infection in unvaccinated Colombian female adolescents, as well as some factors modulating the risk of infection. HPV DNA for six high-risk viral types was identified in cervical samples taken from 2,134 12-19 year-old females using conventional generic and type-specific PCR. Binomial logistical regression analysis was used for modelling HR-HPV infection and multiple infection risk. The interaction between variables in a stepwise model was also included in such analysis. Viral DNA was detected in 48.97% of the females; 28.52% of them had multiple infections, HPV-16 being the most frequently occurring type (37.44%). Cytological abnormality prevalence was 15.61%. Being over 16 years-old (1.66: 1.01-2.71 95%CI), white ethnicity (4.40: 1.16-16.73 95%CI), having had 3 or more sexual partners (1.77: 1.11-2.81 95%CI) and prior sexually-transmitted infections (STI) (1.65: 1.17-2.32 95%CI) were associated with a greater risk of HPV infection. Having given birth was related to a higher risk of infection by A7 species and antecedent of abortion to less risk of coinfection. Where the females in this study came from also influenced the risk of infection by A7 species as female adolescents from the Andean region had a lower risk of infection (0.42: 0.18-0.99 95%CI). The presence of factors related to risky sexual behaviour in the study population indicated that public health services should pay special attention to female adolescents to modify the risk of infection by high-risk HPV types and decrease their impact on this age group.
authors.affiliation: Molecular Biology and Immunology Department, Fundación Instituto de Inmunología de Colombia (FIDIC), Bogotá D.C., Colombia.|School of Medicine, Universidad Nacional de Colombia, Bogotá D.C., Colombia.
authors.forename: Luisa
authors.initials: L
authors.lastname: Del Río-Ospina
authors.affiliation: Molecular Biology and Immunology Department, Fundación Instituto de Inmunología de Colombia (FIDIC), Bogotá D.C., Colombia.|Universidad de Ciencias Aplicadas y Ambientales (UDCA), Bogotá D.C., Colombia.
authors.forename: Sara Cecilia
authors.initials: SC
authors.lastname: Soto-De León
authors.affiliation: Molecular Biology and Immunology Department, Fundación Instituto de Inmunología de Colombia (FIDIC), Bogotá D.C., Colombia.|PhD Programme in Biomedical and Biological Sciences, Universidad del Rosario, Bogotá D.C., Colombia.
authors.forename: Milena
authors.initials: M
authors.lastname: Camargo
authors.affiliation: Molecular Biology and Immunology Department, Fundación Instituto de Inmunología de Colombia (FIDIC), Bogotá D.C., Colombia.|School of Medicine, Universidad Nacional de Colombia, Bogotá D.C., Colombia.
authors.forename: Ricardo
authors.initials: R
authors.lastname: Sánchez
authors.affiliation: Molecular Biology and Immunology Department, Fundación Instituto de Inmunología de Colombia (FIDIC), Bogotá D.C., Colombia.
authors.forename: Cindy Lizeth
authors.initials: CL
authors.lastname: Mancilla
authors.affiliation: Molecular Biology and Immunology Department, Fundación Instituto de Inmunología de Colombia (FIDIC), Bogotá D.C., Colombia.|School of Medicine, Universidad Nacional de Colombia, Bogotá D.C., Colombia.
authors.forename: Manuel Elkin
authors.initials: ME
authors.lastname: Patarroyo
authors.affiliation: Molecular Biology and Immunology Department, Fundación Instituto de Inmunología de Colombia (FIDIC), Bogotá D.C., Colombia.|School of Medicine and Health Sciences, Universidad del Rosario, Bogotá D.C., Colombia.
authors.forename: Manuel Alfonso
authors.identifier: http://orcid.org/0000-0002-4751-2500
authors.initials: MA
authors.lastname: Patarroyo
mesh_terms: D000293:Adolescent; D002584:Cervix Uteri / Q000473:pathology / Q000821:virology; D002648:Child; D003105:Colombia / Q000453:epidemiology; D003430:Cross-Sectional Studies; D004279:DNA, Viral / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D015233:Models, Statistical; D027383:Papillomaviridae / Q000145:classification* / Q000235:genetics / Q000472:pathogenicity / Q000502:physiology; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000523:psychology / Q000635:transmission / Q000821:virology; D016133:Polymerase Chain Reaction; D015995:Prevalence; D012309:Risk-Taking; D012725:Sexual Behavior / Q000523:psychology*; D012747:Sexual Partners / Q000523:psychology
chemical_list: D004279:DNA, Viral