title: High-Frequency Ventilation as a Mode of Noninvasive Respiratory Support.
abstract: High-frequency ventilation (HFV) as a mode of noninvasive respiratory support (NRS) in preterm neonates is gaining popularity. Benefits may accrue from combining the ventilatory efficiency of HFV delivered through a noninvasive interface, enhancing respiratory support while potentially limiting lung injury. Current evidence suggests that noninvasive HFV (NIHFV) may be superior to other NRS modes in eliminating carbon dioxide and preventing endotracheal ventilation after failure of other NRS modes. Animal data suggest NIHFV may promote improved alveolar development compared to endotracheal ventilation. However, adequately powered large-scale controlled trials are required to evaluate efficacy and safety prior to widespread use of NIHFV.
authors.affiliation: Division of Neonatology, Department of Pediatrics, McMaster Children's Hospital, McMaster University, 1280 Main Street West, HSC-4F1E, Hamilton, Ontario L8S 4K1, Canada. Electronic address: mukerji@mcmaster.ca.
authors.forename: Amit
authors.initials: A
authors.lastname: Mukerji
authors.affiliation: Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada; Department of Newborn and Developmental Pediatrics, Sunnybrook Health Sciences Centre, Room M4-222, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada.
authors.forename: Michael
authors.initials: M
authors.lastname: Dunn
mesh_terms: D001997:Bronchopulmonary Dysplasia / Q000453:epidemiology; D006612:High-Frequency Ventilation / Q000379:methods*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D063087:Noninvasive Ventilation / Q000379:methods*; D012127:Respiratory Distress Syndrome, Newborn / Q000628:therapy*; D055397:Ventilator-Induced Lung Injury / Q000517:prevention & control
keywords: Alveolar development; Bronchopulmonary dysplasia; Nasal intermittent positive pressure ventilation; Noninvasive high-frequency ventilation; Postextubation prophylaxis; Ventilation efficacy; Ventilator-induced lung injury