title: Starch functionalized biodegradable semi-IPN as a pH-tunable controlled release platform for memantine.
abstract: Sequentially prepared semi-interpenetrating polymer network (semi-IPN) has been developed here via Michael type addition of acrylic acid (AA) and 2-acrylamido-2-methylpropane sulfonic acid (AMPS) on to starch. The semi-IPN hydrogel have proficiency in fast water imbibition towards gel network and swelling tunable character with pH alteration in ambient condition. The synthesized gel has been characterized by Fourier transformed infrared spectroscopy (FTIR) to confirm Michael type grafting of monomers on to starch. The surface morphology, observed from Scanning Electron Microscopy (SEM) exhibited corrugated rough surface on hydrogel which enhances the fast water uptake feature by anomalous Fickian case II diffusion mechanism. Grafting reaction also improves its thermal stability which has been confirmed by thermogravimetric analysis (TGA). Biodegradation study with hen egg lysozyme medium reveals the accelerated enzymatic scission of the starch backbone and progressive mass loss. Degradation of the hydrogel around 60% of its primary mass has been observed within 7days. The physicochemical characterizations of this hydrogel suggest this as a promising pH-tunable, biodegradable candidate for control drug delivery vehicle.
authors.affiliation: Rubber Technology Centre, Indian Institute of Technology, Kharagpur 721302, India.
authors.forename: Sayan
authors.initials: S
authors.lastname: Ganguly
authors.affiliation: Rubber Technology Centre, Indian Institute of Technology, Kharagpur 721302, India.
authors.forename: Tushar
authors.initials: T
authors.lastname: Maity
authors.affiliation: Rubber Technology Centre, Indian Institute of Technology, Kharagpur 721302, India.
authors.forename: Subhadip
authors.initials: S
authors.lastname: Mondal
authors.affiliation: School of Nanoscience and Technology, Indian Institute of Technology, Kharagpur 721302, India.
authors.forename: Poushali
authors.initials: P
authors.lastname: Das
authors.affiliation: Rubber Technology Centre, Indian Institute of Technology, Kharagpur 721302, India. Electronic address: ncdas@rtc.iitkgp.ernet.in.
authors.forename: Narayan C
authors.initials: NC
authors.lastname: Das
mesh_terms: D000818:Animals; D003692:Delayed-Action Preparations; D004058:Diffusion; D004337:Drug Carriers / Q000737:chemistry* / Q000378:metabolism*; D065546:Drug Liberation; D004355:Drug Stability; D020100:Hydrogels / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008559:Memantine / Q000737:chemistry*; D013213:Starch / Q000737:chemistry* / Q000378:metabolism*; D013696:Temperature; D014867:Water / Q000737:chemistry
chemical_list: D003692:Delayed-Action Preparations; D004337:Drug Carriers; D020100:Hydrogels; D014867:Water; D013213:Starch; D008559:Memantine
keywords: Biodegradation; Corrugated rough surface; Drug delivery; Semi interpenetrating polymer network; Water imbibition; pH-tunable