title: Plasma Level of Soluble Urokinase-type Plasminogen Activator Receptor Predicts the Severity of Acute Alcohol Pancreatitis.
abstract: Systemic levels of soluble urokinase-type plasminogen activator receptor (suPAR) are increased in various inflammatory and infectious diseases. We investigated the activation and prognostic value of plasma suPAR (P-suPAR) in patients experiencing their first acute alcohol pancreatitis (AAP).
  
  
  
  From prospectively collected data, we measured P-suPAR concentrations in 104 patients with AAP during hospitalization and again after discharge.
  
  
  
  According to the revised Atlanta classification, pancreatitis was moderately severe in 29 (28%) and severe in 6 (6%) patients and these severities were combined for further analysis (non-mild AAP, n = 35; 34%). Median P-suPAR levels were significantly higher in patients with AAP during hospitalization than after discharge (4.8 vs 3.1 ng/mL; P < 0.001) and in non-mild compared to mild AAP (6.2 vs 4.2 ng/mL; P < 0.001). When the analysis was made 1 to 4 days after admission (n = 68), the area under the curve was 0.81 (95% confidence interval, 0.70-0.92). P-suPAR was found to be a better prognostic marker in AAP than C-reactive protein, hematocrit, or creatinine.
  
  
  
  P-suPAR concentrations are elevated in AAP and correlate with the severity of the disease. These results suggest that P-suPAR may have potential to serve as a novel prognostic marker for AAP severity on admission.
authors.affiliation: From the *Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital; †University of Tampere, School of Medicine; ‡Fimlab Laboratories; and §Department of Internal Medicine, Tampere University Hospital, Tampere, Finland.
authors.forename: Anssi
authors.initials: A
authors.lastname: Nikkola
authors.forename: Janne
authors.initials: J
authors.lastname: Aittoniemi
authors.forename: Reetta
authors.initials: R
authors.lastname: Huttunen
authors.forename: Linnea
authors.initials: L
authors.lastname: Rajala
authors.forename: Isto
authors.initials: I
authors.lastname: Nordback
authors.forename: Juhani
authors.initials: J
authors.lastname: Sand
authors.forename: Johanna
authors.initials: J
authors.lastname: Laukkarinen
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019512:Pancreatitis, Alcoholic / Q000097:blood* / Q000175:diagnosis; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D012372:ROC Curve; D055293:Receptors, Urokinase Plasminogen Activator / Q000097:blood*; D012720:Severity of Illness Index; D055815:Young Adult
chemical_list: D015415:Biomarkers; D055293:Receptors, Urokinase Plasminogen Activator