title: Natural Killer Cells to the Attack: Combination Therapy against Neuroblastoma.
abstract: TGFβ in the tumor microenvironment diminishes natural killer (NK) cell-mediated anti-disialoganglioside (anti-GD2) mAb elimination of neuroblastoma cells. Consequently, blockade of TGFβ signaling with galunisertib in combination with the anti-GD2 mAb dinutuximab plus adoptively transferred NK cells is a promising tool for the treatment of neuroblastoma. Clin Cancer Res; 23(3); 615-7. ©2016 AACRSee related article by Tran et al., p. 804.
authors.affiliation: Immunopathology Group, BioCruces Health Research Institute, Barakaldo, Spain.
authors.forename: Olatz
authors.initials: O
authors.lastname: Zenarruzabeitia
authors.affiliation: Immunopathology Group, BioCruces Health Research Institute, Barakaldo, Spain.
authors.forename: Joana
authors.initials: J
authors.lastname: Vitallé
authors.affiliation: Pediatric Oncology Group, BioCruces Health Research Institute, Barakaldo, Spain.|Pediatrics Service, Cruces University Hospital, Barakaldo, Spain.|Department of Pediatrics, Faculty of Medicine and Dentistry, University of the Basque Country, Leioa, Spain.
authors.forename: Itziar
authors.initials: I
authors.lastname: Astigarraga
authors.affiliation: Immunopathology Group, BioCruces Health Research Institute, Barakaldo, Spain. francisco.borregorabasco@osakidetza.eus.|Immunotherapy Group, Center for Transfusion and Human Tissues, Galdakao, Spain.|Ikerbasque, Basque Foundation for Science, Bilbao, Spain.
authors.forename: Francisco
authors.initials: F
authors.lastname: Borrego
mesh_terms: D000911:Antibodies, Monoclonal; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology; D009447:Neuroblastoma / Q000276:immunology*; D011720:Pyrazoles; D011804:Quinolines; D059016:Tumor Microenvironment
chemical_list: D000911:Antibodies, Monoclonal; D011720:Pyrazoles; D011804:Quinolines; C557799:LY-2157299; C112746:dinutuximab