title: French consensus. Idiopathic hypersomnia: Investigations and follow-up.
abstract: Idiopathic hypersomnia is a rare, central hypersomnia, recently identified and to date of unknown physiopathology. It is characterised by a more or less permanent, excessive daytime sleepiness, associated with long and unrefreshing naps. Night-time sleep is of good quality, excessive in quantity, associated with sleep inertia in the subtype previously described as "with long sleep time". Diagnosis of idiopathic hypersomnia is complex due to the absence of a quantifiable biomarker, the heterogeneous symptoms, which overlap with the clinical picture of type 2 narcolepsy, and its variable evolution over time. Detailed evaluation enables other frequent causes of somnolence, such as depression or sleep deprivation, to be eliminated. Polysomnography and multiple sleep latency tests (MSLT) are essential to rule out other sleep pathologies and to objectify excessive daytime sleepiness. Sometimes the MSLT do not show excessive sleepiness, hence a continued sleep recording of at least 24hours is necessary to show prolonged sleep (>11h/24h). In this article, we propose recommendations for the work-up to be carried out during diagnosis and follow-up for patients suffering from idiopathic hypersomnia.
authors.affiliation: Centre de référence nationale narcolepsie et hypersomnie idiopathique, 34295 Montpellier cedex 5, France; Service de pathologies du sommeil, GH Pitié-Salpêtrière/Charles-Foix, AP-HP, 75013 Paris, France; Inserm U 1127, CNRS UMR 7225, centre de recherche de l'institut du cerveau et de la moelle épinière, UPMC-Paris 6, 75013 Paris, France.
authors.forename: S
authors.initials: S
authors.lastname: Leu-Semenescu
authors.affiliation: EA 4047, CIC 1429, AP-HP, unité des troubles du sommeil et de l'éveil, centre de référence narcolepsie-hypersomnies hôpital Raymond-Poincaré, 92380 Garches, France.
authors.forename: M-A
authors.initials: MA
authors.lastname: Quera-Salva
authors.affiliation: Centre de référence nationale narcolepsie et hypersomnie idiopathique, 34295 Montpellier cedex 5, France; Unité des troubles du sommeil et de l'éveil, service de neurologie, hôpital Gui-De-Chauliac, 80, avenue Augustin-Fliche, 34295 Montpellier cedex 5, France; Inserm U1061, 34295 Montpellier, France. Electronic address: ydauvilliers@yahoo.fr.
authors.forename: Y
authors.initials: Y
authors.lastname: Dauvilliers
mesh_terms: D000359:Aftercare / Q000379:methods; D003937:Diagnosis, Differential; D003943:Diagnostic Techniques, Neurological; D005500:Follow-Up Studies; D005602:France / Q000453:epidemiology; D006801:Humans; D020177:Idiopathic Hypersomnia / Q000175:diagnosis* / Q000453:epidemiology / Q000628:therapy*; D017286:Polysomnography
keywords: Biomarker; Continuous polysomnography; Diagnosis; Excessive sleepiness; GABA; Idiopathic hypersomnia