title: Taurolidine in Pediatric Home Parenteral Nutrition Patients.
abstract: To reduce the incidence of catheter-related bloodstream infections in home parenteral nutrition patients, the use of taurolidine was introduced in the Sophia Children's Hospital in 2011. This introduction led to a reduction in catheter-related bloodstream infections: 12.7/1000 catheter days before the use of taurolidine, compared with 4.3/1000 catheter days afterwards (n = 7) [relative risk = 0.36, 95% confidence interval: 0.20-0.65 (P = 0.018)].
authors.affiliation: From the *Department of Hospital Pharmacy, Erasmus MC, Sophia Children's Hospital, Rotterdam, the Netherlands; †Department of Dietetics, Erasmus MC, Sophia Children's Hospital, Rotterdam, the Netherlands; ‡Department of Paediatric Surgery, Erasmus MC, Sophia Children's Hospital, Rotterdam, the Netherlands; §Department of Infectious Disease and Immunology, Erasmus MC, Sophia Children's Hospital, Rotterdam, the Netherlands; and ¶Department of Paediatric Gastroenterology, Erasmus MC, Sophia Children's Hospital, Rotterdam, the Netherlands.
authors.forename: Emma Claire
authors.initials: EC
authors.lastname: Hulshof
authors.forename: Lidwien Marieke
authors.initials: LM
authors.lastname: Hanff
authors.forename: Joanne
authors.initials: J
authors.lastname: Olieman
authors.forename: Susanna
authors.initials: S
authors.lastname: de Vette
authors.forename: Gert-Jan
authors.initials: GJ
authors.lastname: Driessen
authors.forename: Conny
authors.initials: C
authors.lastname: Meeussen
authors.forename: Johanna Caroline
authors.initials: JC
authors.lastname: Escher
mesh_terms: D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D016470:Bacteremia / Q000188:drug therapy / Q000453:epidemiology / Q000517:prevention & control; D055499:Catheter-Related Infections / Q000188:drug therapy / Q000453:epidemiology / Q000517:prevention & control; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D016331:Parenteral Nutrition, Home / Q000009:adverse effects / Q000379:methods / Q000706:statistics & numerical data*; D012189:Retrospective Studies; D013654:Taurine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D013829:Thiadiazines / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D000890:Anti-Infective Agents; D013829:Thiadiazines; D013654:Taurine; C012566:taurolidine