title: Gold(i)-catalyzed addition of aldehydes to cyclopropylidene bearing 6-aryl-1,5-enynes.
abstract: A diastereoselective, gold-catalyzed cascading cycloisomerization of alkylidene cyclopropane bearing 1,5-enynes that terminates in a cyclo-addition of aldehydes has been developed. This diastereoselective reaction provides convergent access to novel polycyclic molecular structures (18 examples), and tolerates a diverse scope of aldehydes. Mechanistic studies reveal that the catalytic cycle rests at a digold off-cycle intermediate, one of which was isolated.
authors.affiliation: Department of Chemistry. University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3290, USA. mgagne@unc.edu.
authors.forename: Christina A
authors.initials: CA
authors.lastname: Roselli
authors.affiliation: Department of Chemistry. University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3290, USA. mgagne@unc.edu.
authors.forename: Michel R
authors.initials: MR
authors.lastname: Gagné