title: Thyroid metastasis from lung adenocarcinoma with EML4-ALK rearrangement.
abstract: Thyroid metastases from lung cancer are very rare. A woman aged 42 years with a tumour in the lower lobe of the right lung was diagnosed as having lung adenocarcinoma positive for echinoderm microtubule-associated proteinlike 4-anaplastic lymphoma kinase. Positron emission tomography demonstrated fluorodeoxyglucose accumulation in the lower lobe of the right lung, the right thyroid lobe and both adrenal glands. We performed fine-needle aspiration biopsy (FNAB) and used reverse transcriptase-PCR (RT-PCR) to diagnose the patient as having metastatic lung adenocarcinoma to the thyroid gland. We believe that FNAB combined with RT-PCR can be an effective method for diagnosing metastatic lung adenocarcinoma to the thyroid gland.
authors.affiliation: Department of Respiratory Medicine, Tokyo Jikeikai Ika Daigaku Fuzoku Daisan Byoin, Komae, Japan.|Department of Respiratory Medicine, Tokyo Jikeikai Ika Daigaku, Minato-ku, Japan.
authors.forename: Hironori
authors.initials: H
authors.lastname: Kawamoto
authors.affiliation: Division of Respiratory Diseases, Department of Internal Medicine, The Jikei University Daisan Hospital, Tokyo, Japan.
authors.forename: Yugo
authors.initials: Y
authors.lastname: Kaneko
authors.affiliation: Tokyo Jikeikai Ika Daigaku Fuzoku Daisan Byoin, Komae, Japan.
authors.forename: Kai
authors.initials: K
authors.lastname: Ryu
authors.affiliation: Department of Respiratory Medicine, Jikei University School of Medicine, Tokyo, Japan.
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Kuwano
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000473:pathology* / Q000556:secondary*; D000328:Adult; D044963:Biopsy, Fine-Needle; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013964:Thyroid Neoplasms / Q000175:diagnosis / Q000556:secondary*