title: The Role of Interleukin-17 in Lung Cancer.
abstract: Tumour-associated inflammation is a hallmark of malignant carcinomas, and lung cancer is a typical inflammation-associated carcinoma. Interleukin-17 (IL-17) is an important inflammatory cytokine that plays an important role in chronic inflammatory and autoimmune diseases and in inflammation-associated tumours. Numerous studies have shown that IL-17 directly or indirectly promotes tumour angiogenesis and cell proliferation and that it inhibits apoptosis via the activation of inflammatory signalling pathways. Therefore, IL-17 contributes to the metastasis and progression of lung cancer. Research advances with respect to the role of IL-17 in lung cancer will be presented as a review in this paper.
authors.affiliation: Key Laboratory of Respiratory Diseases, Ministry of Health, Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Wu
authors.affiliation: Key Laboratory of Respiratory Diseases, Ministry of Health, Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China.
authors.forename: Juanjuan
authors.identifier: 0000-0001-9874-3205
authors.initials: J
authors.lastname: Xu
authors.affiliation: Key Laboratory of Respiratory Diseases, Ministry of Health, Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Huang
authors.affiliation: Key Laboratory of Respiratory Diseases, Ministry of Health, Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China.
authors.forename: Jieli
authors.initials: J
authors.lastname: Han
authors.affiliation: Key Laboratory of Respiratory Diseases, Ministry of Health, Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China.
authors.forename: Limin
authors.initials: L
authors.lastname: Duan
authors.affiliation: Key Laboratory of Respiratory Diseases, Ministry of Health, Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China.
authors.forename: Jinshuo
authors.initials: J
authors.lastname: Fan
authors.affiliation: Key Laboratory of Respiratory Diseases, Ministry of Health, Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China.
authors.forename: Zhilei
authors.initials: Z
authors.lastname: Lv
authors.affiliation: Key Laboratory of Respiratory Diseases, Ministry of Health, Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China.
authors.forename: Mengfei
authors.initials: M
authors.lastname: Guo
authors.affiliation: Key Laboratory of Respiratory Diseases, Ministry of Health, Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China.
authors.forename: Guorong
authors.initials: G
authors.lastname: Hu
authors.affiliation: Key Laboratory of Respiratory Diseases, Ministry of Health, Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China.
authors.forename: Lian
authors.initials: L
authors.lastname: Chen
authors.affiliation: Key Laboratory of Respiratory Diseases, Ministry of Health, Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China.
authors.forename: Shuai
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Respiratory Diseases, Ministry of Health, Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China.
authors.forename: Xiaonan
authors.initials: X
authors.lastname: Tao
authors.affiliation: Key Laboratory of Respiratory Diseases, Ministry of Health, Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China.
authors.forename: Wanli
authors.initials: W
authors.lastname: Ma
authors.affiliation: Key Laboratory of Respiratory Diseases, Ministry of Health, Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China.
authors.forename: Yang
authors.identifier: 0000-0003-2409-7073
authors.initials: Y
authors.lastname: Jin
mesh_terms: D000818:Animals; D017209:Apoptosis; D063646:Carcinogenesis; D049109:Cell Proliferation; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007107:Immune System; D007249:Inflammation; D020381:Interleukin-17 / Q000378:metabolism*; D008175:Lung Neoplasms / Q000378:metabolism*; D042583:Lymphangiogenesis; D051379:Mice; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000378:metabolism / Q000503:physiopathology; D009389:Neovascularization, Pathologic; D011379:Prognosis; D015398:Signal Transduction
chemical_list: C508717:IL17A protein, human; D020381:Interleukin-17