title: Comparison of curative surgery and definitive chemoradiotherapy as initial treatment for patients with cervical esophageal cancer.
abstract: Esophagectomy and definitive chemoradiotherapy are recognized standard initial treatment modalities for cervical esophageal cancer. The goal of this study was to compare the treatment outcomes of curative surgery with those of chemoradiotherapy in patients who had potentially resectable tumor and who were candidates for surgery. We evaluated the data from 49 consecutive patients who were diagnosed with potentially resectable cervical esophageal cancer and who were deemed candidates for surgery. Thirteen patients were included in the surgery group, and 36 patients were included in chemoradiotherapy group. Baseline characteristics were balanced between the two groups. In the chemoradiotherapy group, the complete response rate was 58.3%. There was no significant difference in 5-year overall survival when comparing the surgery group and the chemoradiotherapy group (surgery, 60.6%; chemoradiotherapy, 51.4%; P = 0.89). In the chemoradiotherapy group, of the 15 patients who failed to respond to initial treatment, 11 patients subsequently underwent salvage surgery. In conclusion, curative surgery and chemoradiotherapy as initial treatment for cervical esophageal cancer have comparable survival outcomes. Chemoradiotherapy should be selected as the initial larynx-preserving treatment for patients with cervical esophageal cancer although chemoradiotherapy non-responders require additional treatment, including salvage surgery.
authors.affiliation: Divisions of Esophageal Surgery, Shizuoka Cancer Center, 1007 Shimonagakubo Nagaizumi-cho Sunto-gun, Shizuoka, Japan
authors.forename: Katsushi
authors.initials: K
authors.lastname: Takebayashi
authors.affiliation: Divisions of Esophageal Surgery, Shizuoka Cancer Center, 1007 Shimonagakubo Nagaizumi-cho Sunto-gun, Shizuoka, Japan
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Tsubosa
authors.affiliation: Divisions of Esophageal Surgery, Shizuoka Cancer Center, 1007 Shimonagakubo Nagaizumi-cho Sunto-gun, Shizuoka, Japan
authors.forename: Satoru
authors.initials: S
authors.lastname: Matsuda
authors.affiliation: Divisions of Esophageal Surgery, Shizuoka Cancer Center, 1007 Shimonagakubo Nagaizumi-cho Sunto-gun, Shizuoka, Japan
authors.forename: Keisuke
authors.initials: K
authors.lastname: Kawamorita
authors.affiliation: Divisions of Esophageal Surgery, Shizuoka Cancer Center, 1007 Shimonagakubo Nagaizumi-cho Sunto-gun, Shizuoka, Japan
authors.forename: Masahiro
authors.initials: M
authors.lastname: Niihara
authors.affiliation: Gastrointestinal Oncology, Shizuoka Cancer Center, 1007 Shimonagakubo Nagaizumi-cho Sunto-gun, Shizuoka, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Tsushima
authors.affiliation: Gastrointestinal Oncology, Shizuoka Cancer Center, 1007 Shimonagakubo Nagaizumi-cho Sunto-gun, Shizuoka, Japan.
authors.forename: Tomoya
authors.initials: T
authors.lastname: Yokota
authors.affiliation: Division of Gastrointestinal Surgery, Saitama Medical University International Medical Center, Saitama, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sato
authors.affiliation: Gastrointestinal Oncology, Shizuoka Cancer Center, 1007 Shimonagakubo Nagaizumi-cho Sunto-gun, Shizuoka, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Onozawa
authors.affiliation: Radiation Oncology, Shizuoka Cancer Center, 1007 Shimonagakubo, Nagaizumi-cho, Sunto-gun, Shizuoka, Japan.
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Ogawa
authors.affiliation: Head and Neck Surgery, Shizuoka Cancer Center, Nagaizumi, Shizuoka, Japan.
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Kamijo
authors.affiliation: Head and Neck Surgery, Shizuoka Cancer Center, Nagaizumi, Shizuoka, Japan.
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Onitsuka
authors.affiliation: Plastic and Reconstructive Surgery, Shizuoka Cancer Center, Shizuoka, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Nakagawa
authors.affiliation: Gastrointestinal Oncology, Shizuoka Cancer Center, 1007 Shimonagakubo Nagaizumi-cho Sunto-gun, Shizuoka, Japan.
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Yasui
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D059248:Chemoradiotherapy / Q000379:methods*; D018572:Disease-Free Survival; D004938:Esophageal Neoplasms / Q000628:therapy*; D016629:Esophagectomy / Q000379:methods*; D004947:Esophagus / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007830:Larynx / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009333:Neck / Q000601:surgery; D012189:Retrospective Studies; D016879:Salvage Therapy / Q000379:methods*; D016896:Treatment Outcome
keywords: cancer esophagus; cervical esophageal cancer; chemoradiotherapy; esophagectomy; esophagus surgery; salvage surgery