title: Elevated preoperative HMGB1 as predictor of myocardial injury post-percutaneous coronary intervention.
abstract: In this study, we evaluated the impact of preoperative high mobility group box 1 (HMGB1) on myocardial injury post-percutaneous coronary intervention.We evaluated 302 consecutive patients who underwent percutaneous coronary intervention. They were divided into equal tertiles based on their preoperative HMGB1 levels. Creatine kinase-MB and troponin I levels were measured at baseline, 8- and 24-hours after the procedure, while clinical outcomes were followed up for 1 year.The occurrence of post-procedural myocardial injury was significantly higher in the tertile comprising of patients with elevated HMGB1 levels. Moreover, these patients showed significantly higher post-procedural peak values of creatine kinase-MB and troponin I in comparison to patients with lower HMGB1 levels. Event-free survival was significantly associated with HMGB1 levels, with worst event-free survival in patients with elevated HMGB1 levels.Elevated preoperative HMGB1 was a predictor of myocardial injury after percutaneous coronary intervention, and was associated with the worst clinical outcomes during 1-year follow up.
authors.affiliation: Department of Cardiology, China National Petroleum Corporation Central Hospital, Langfang, Hebei, China Department of Cardiology, Affiliated Hospital of Hebei University, Baoding, Hebei, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Jin
authors.forename: Qi
authors.initials: Q
authors.lastname: Zhou
authors.forename: Shujiang
authors.initials: S
authors.lastname: Song
authors.forename: Jinpeng
authors.initials: J
authors.lastname: Xu
authors.forename: Minli
authors.initials: M
authors.lastname: Zhang
authors.forename: Ming
authors.initials: M
authors.lastname: Zhu
authors.forename: Meili
authors.initials: M
authors.lastname: Kang
authors.forename: Xiangming
authors.initials: X
authors.lastname: Shi
authors.forename: Junting
authors.initials: J
authors.lastname: Shi
authors.forename: Di
authors.initials: D
authors.lastname: Lu
authors.forename: Jing
authors.initials: J
authors.lastname: Li
mesh_terms: D009202:Cardiomyopathies / Q000097:blood / Q000209:etiology*; D005260:Female; D024243:HMGB1 Protein / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D062645:Percutaneous Coronary Intervention; D011183:Postoperative Complications / Q000097:blood / Q000209:etiology*; D011237:Predictive Value of Tests; D057234:Preoperative Period; D011446:Prospective Studies
chemical_list: D024243:HMGB1 Protein