title: Mechanisms of Drug-Induced Hepatotoxicity.
abstract: Drug-induced hepatotoxicity (DIH) is a significant cause of acute liver failure and liver transplantation. Diagnosis is challenging due to the idiosyncratic nature, its presentation in the form of other liver disease, and the lack of a definite diagnostic criteria. Generation of reactive metabolites, oxidative stress, and mitochondrial dysfunction are common mechanisms involved in DIH. Certain risk factors associated with a drug and within an individual further predispose patients to DIH.
authors.affiliation: Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, 3rd Floor Salk Pavillion, Pittsburgh, PA 15261, USA.
authors.forename: Amina Ibrahim
authors.initials: AI
authors.lastname: Shehu
authors.affiliation: Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, 3rd Floor Salk Pavillion, Pittsburgh, PA 15261, USA.
authors.forename: Xiaochao
authors.initials: X
authors.lastname: Ma
authors.affiliation: Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, 718 Salk Hall, 3501 Terrace Street, Pittsburgh, PA 15261, USA. Electronic address: RV@pitt.edu.
authors.forename: Raman
authors.initials: R
authors.lastname: Venkataramanan
mesh_terms: D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008099:Liver / Q000187:drug effects*; D017114:Liver Failure, Acute / Q000139:chemically induced* / Q000401:mortality* / Q000503:physiopathology; D008297:Male; D020380:Needs Assessment; D018384:Oxidative Stress; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D011379:Prognosis; D018570:Risk Assessment; D015996:Survival Rate
chemical_list: D004364:Pharmaceutical Preparations
keywords: Cholestasis; Hepatocellular; Hepatotoxicity; Mitochondria; Reactive metabolites