title: Unravelling the genomic architecture of bull fertility in Holstein cattle.
abstract: Fertility is considered an important economic trait in dairy cattle. Most studies have investigated cow fertility while bull fertility has received much less consideration. The main objective of this study was to perform a comprehensive genomic analysis in order to unravel the genomic architecture underlying sire fertility in Holstein dairy cattle. The analysis included the application of alternative genome-wide association mapping approaches and the subsequent use of diverse gene set enrichment tools.
  
  
  
  The association analyses identified at least eight genomic regions strongly associated with bull fertility. Most of these regions harbor genes, such as KAT8, CKB, TDRD9 and IGF1R, with functions related to sperm biology, including sperm development, motility and sperm-egg interaction. Moreover, the gene set analyses revealed many significant functional terms, including fertilization, sperm motility, calcium channel regulation, and SNARE proteins. Most of these terms are directly implicated in sperm physiology and male fertility.
  
  
  
  This study contributes to the identification of genetic variants and biological processes underlying sire fertility. These findings can provide opportunities for improving bull fertility via marker-assisted selection.
authors.affiliation: Department of Animal Sciences, University of Florida, 2250 Shealy Drive, Gainesville, FL, 32611, USA.|University of Florida Genetics Institute, University of Florida, Gainesville, FL, 32610, USA.
authors.forename: Yi
authors.initials: Y
authors.lastname: Han
authors.affiliation: Department of Animal Sciences, University of Florida, 2250 Shealy Drive, Gainesville, FL, 32611, USA. fpenagaricano@ufl.edu.|University of Florida Genetics Institute, University of Florida, Gainesville, FL, 32610, USA. fpenagaricano@ufl.edu.
authors.forename: Francisco
authors.identifier: 0000-0001-6661-3991
authors.initials: F
authors.lastname: Peñagaricano
mesh_terms: D000818:Animals; D002417:Cattle / Q000235:genetics* / Q000502:physiology*; D005306:Fertilization / Q000235:genetics*; D005819:Genetic Markers / Q000235:genetics; D023281:Genomics; D008297:Male; D013094:Spermatozoa / Q000502:physiology
chemical_list: D005819:Genetic Markers
keywords: Bovine sperm; Conception rate; Gene set analysis; Whole-genome scan