title: Uncovering Metabolic Effects of Anti-angiogenic Therapy in Tumors by Induced Metabolic Bioluminescence Imaging.
abstract: Induced metabolic bioluminescence imaging (imBI) is an imaging technique which enables detection of various metabolites associated with glycolysis in tumor sections. Signals captured by imBI can be used to chart the topographic distribution of lactate, glucose, pyruvate, and ATP and quantify their absolute amount. ImBi can enable us to perform metabolic classification of tumors as well as to detect metabolic changes in the glycolytic pathway associated with certain therapies, such as anti-angiogenic drugs.
authors.affiliation: Istituto Oncologico Veneto - IRCCS, Via Gattamelata, 64, 35128, Padova, Italy. stefano.indraccolo@unipd.it.
authors.forename: Stefano
authors.initials: S
authors.lastname: Indraccolo
authors.affiliation: Institute of Pathophysiology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Walenta
authors.affiliation: Institute of Pathophysiology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Mueller-Klieser
mesh_terms: D020533:Angiogenesis Inhibitors / Q000008:administration & dosage* / Q000494:pharmacology; D000818:Animals; D000068258:Bevacizumab / Q000008:administration & dosage* / Q000494:pharmacology; D045744:Cell Line, Tumor; D005260:Female; D006019:Glycolysis / Q000187:drug effects; D006801:Humans; D008163:Luminescent Measurements / Q000379:methods*; D051379:Mice; D016513:Mice, SCID; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D023041:Xenograft Model Antitumor Assays
chemical_list: D020533:Angiogenesis Inhibitors; D000068258:Bevacizumab
keywords: Angiogenesis; Bioluminescence; Glycolysis; Imaging; Tumor xenografts