title: Peroxisome proliferator-activated receptor α ligands and modulators from dietary compounds: Types, screening methods and functions.
abstract: Peroxisome proliferator-activated receptor α (PPARα) plays a key role in lipid metabolism and glucose homeostasis and a crucial role in the prevention and treatment of metabolic diseases. Natural dietary compounds, including nutrients and phytochemicals, are PPARα ligands or modulators. High-throughput screening assays have been developed to screen for PPARα ligands and modulators in our diet. In the present review, we discuss recent advances in our knowledge of PPARα, including its structure, function, and ligand and modulator screening assays, and summarize the different types of dietary PPARα ligands and modulators.
authors.affiliation: Cardiovascular Research Center, Xi'an Jiaotong University, Xi'an, China.|Department of Nutrition and Food Safety, School of Public Health, Xi'an Jiaotong University, Xi'an, China.
authors.forename: Haixia
authors.initials: H
authors.lastname: Yang
authors.affiliation: Cardiovascular Research Center, Xi'an Jiaotong University, Xi'an, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Xiao
authors.affiliation: The Advanced Institute for Medical Sciences, Dalian Medical University, Dalian, China.
authors.forename: Nanping
authors.initials: N
authors.lastname: Wang
mesh_terms: D000818:Animals; D001688:Biological Products / Q000378:metabolism / Q000494:pharmacology; D005786:Gene Expression Regulation / Q000187:drug effects; D057166:High-Throughput Screening Assays / Q000379:methods*; D006801:Humans; D008024:Ligands; D047493:PPAR alpha / Q000819:agonists* / Q000235:genetics / Q000378:metabolism*; D064209:Phytochemicals / Q000378:metabolism / Q000494:pharmacology; D011485:Protein Binding; D020798:Two-Hybrid System Techniques
chemical_list: D001688:Biological Products; D008024:Ligands; D047493:PPAR alpha; D064209:Phytochemicals
keywords: diet; ligand; modulator; peroxisome proliferator-activated receptor α; screening methods; 筛选方法; 调节剂; 过氧化物酶体增殖物活化受体α; 配体; 饮食