title: Mass Forming Eosinophilic Cystitis in Pediatric Patients.
abstract: Eosinophilic cystitis (EC) is an uncommon inflammatory disorder of uncertain etiology that has been described in adult and pediatric populations. We describe 3 recent cases of EC that presented as a mass lesion in pediatric patients from the New England region of the United States. All patients were initially suspected to have a malignancy, and biopsy was performed, which ultimately led to the diagnosis of EC. We propose the use of eosinophil density of >25 eosinophils per high-power field and myocyte degeneration as supportive histopathologic features to make this diagnosis. It is of utmost importance to consider EC in the differential diagnosis when approaching a pediatric patient with a bladder mass.
authors.affiliation: Department of Pathology, University of Massachusetts Medical School, Worcester, MA. Electronic address: amy.zhou@umassmemorial.org.
authors.forename: Amy G
authors.initials: AG
authors.lastname: Zhou
authors.affiliation: Department of Pathology and Laboratory Medicine, Warren Alpert Medical School of Brown University and The Miriam Hospital, Providence, RI.
authors.forename: Ali
authors.initials: A
authors.lastname: Amin
authors.affiliation: Department of Urology, University of Massachusetts Medical School, Worcester, MA.
authors.forename: Jennifer K
authors.initials: JK
authors.lastname: Yates
authors.affiliation: Department of Urology, Boston Children's Hospital, Boston, MA.
authors.forename: David A
authors.initials: DA
authors.lastname: Diamond
authors.affiliation: Department of Radiology, University of Massachusetts Medical School, Worcester, MA.
authors.forename: Monique M
authors.initials: MM
authors.lastname: Tyminski
authors.affiliation: Department of Urology, Boston Children's Hospital, Boston, MA.
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Badway
authors.affiliation: Department of Urology, University of Massachusetts Medical School, Worcester, MA.
authors.forename: Pamela I
authors.initials: PI
authors.lastname: Ellsworth
authors.affiliation: Department of Surgery, University of Massachusetts Medical School, Worcester, MA.
authors.forename: Jeremy T
authors.initials: JT
authors.lastname: Aidlen
authors.affiliation: Department of Pathology, University of Massachusetts Medical School, Worcester, MA.
authors.forename: Christopher L
authors.initials: CL
authors.lastname: Owens
mesh_terms: D000293:Adolescent; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D001706:Biopsy; D002675:Child, Preschool; D003556:Cystitis / Q000175:diagnosis* / Q000628:therapy; D003937:Diagnosis, Differential; D004802:Eosinophilia / Q000175:diagnosis* / Q000628:therapy; D004804:Eosinophils / Q000473:pathology*; D006801:Humans; D006854:Hydrocortisone / Q000008:administration & dosage; D007958:Leukocyte Count; D008279:Magnetic Resonance Imaging; D008297:Male; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography; D001743:Urinary Bladder / Q000000981:diagnostic imaging*; D013521:Urologic Surgical Procedures, Male / Q000379:methods; D019459:Urothelium / Q000473:pathology
chemical_list: D000893:Anti-Inflammatory Agents; D006854:Hydrocortisone