title: Hepatoprotective effects of pantothenic acid on carbon tetrachloride-induced toxicity in rats.
abstract: The present study was undertaken to investigate the hepatoprotective effect of pantothenic acid on CCl4-induced liver damage. Male Wistar rats were orally treated with pantothenic acid (0.005, 0.01, 0.025, 0.05 and 0.1 g/kg) daily, with administration of CCl4(1 mL/kg, 50 % CCl4in olive oil) twice a week for 28 days. The effect of pantothenic acid on serum markers (alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and γ-glutamyltransferase) was measured in CCl4-induced hepatotoxicity in rat. Further, the effects on enzymatic antioxidant (superoxide dismutase) were estimated in the liver samples. CCl4challenge not only elevated the serum marker enzyme activities but also suppressed hepatic antioxidative defense system including superoxide dismutase. The biochemical observations were supplemented with histopathological examination of rat liver sections. Histopathological examination of livers showed that pantothenic acid reduced fatty degeneration, cytoplasmic vacuolization and necrosis in CCl4-treated rats. Therefore, pantothenic acid may be an effective hepatoprotective agent and viable candidate for treating hepatic disorders and other oxidative stress-related diseases.
authors.affiliation: Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran.
authors.forename: Akram
authors.initials: A
authors.lastname: Eidi
authors.affiliation: Department of Pathology, Faculty of Specialized Veterinary Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran.
authors.forename: Pejman
authors.initials: P
authors.lastname: Mortazavi
authors.affiliation: Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran.
authors.forename: Masoud Ebrahim
authors.initials: ME
authors.lastname: Tehrani
authors.affiliation: Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran.
authors.forename: Ali Haeri
authors.initials: AH
authors.lastname: Rohani
authors.affiliation: Department of Clinical Pathology, Faculty of Specialized Veterinary Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran.
authors.forename: Shahabaldin
authors.initials: S
authors.lastname: Safi
keywords: antioxidant; carbon tetrachloride; hepatoprotective effects; pantothenic acid; rats