title: Renoprotective effect of low-molecular-weight sulfated polysaccharide from the seaweed Laminaria japonica on glycerol-induced acute kidney injury in rats.
abstract: We investigated the renal protective effect of low-molecular-weight sulfated polysaccharide (LMWSP) fractions extracted from Laminaria japonica on glycerol-induced acute kidney injury (AKI) in rats. Glycerol treatment significantly increased serum creatinine (SCr) and blood urea nitrogen (BUN) levels. Intraperitoneal injection of LMWSP fractions markedly decreased SCr and BUN levels and reduced renal swelling. The fraction of 1.0M NaCl displayed the best renal protective effect of all fractions in attenuating AKI and maintaining blood glucose.
authors.affiliation: Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, China; University of the Chinese Academy of Sciences, Beijing 100049, China.
authors.forename: Xinpeng
authors.initials: X
authors.lastname: Li
authors.affiliation: Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, China; Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.affiliation: Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, China; Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, China; Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao, China. Electronic address: qbzhang@qdio.ac.cn.
authors.forename: Quanbin
authors.initials: Q
authors.lastname: Zhang
mesh_terms: D058186:Acute Kidney Injury / Q000097:blood / Q000139:chemically induced / Q000473:pathology*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D019610:Cytoprotection / Q000187:drug effects; D005990:Glycerol / Q000494:pharmacology*; D017665:Hydroxyl Radical / Q000737:chemistry; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D007795:Laminaria / Q000737:chemistry*; D008970:Molecular Weight; D009929:Organ Size / Q000187:drug effects; D011134:Polysaccharides / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D012624:Seaweed / Q000737:chemistry*; D013431:Sulfates / Q000737:chemistry*; D013481:Superoxides / Q000737:chemistry
chemical_list: D011134:Polysaccharides; D013431:Sulfates; D013481:Superoxides; D017665:Hydroxyl Radical; D005990:Glycerol
keywords: Acute kidney injury; Low-molecular-weight sulfated polysaccharide; Renal protective effect