title: Pattern of adhesive molecules expression in placenta of non-complicated ART pregnancies.
abstract: To investigate changes occurring in the morphometric parameters of chorionic villi and their vessels as well as in adhesive molecules expression in placenta of ART pregnancies.
  
  
  
  Case-control study including a total of 52 placentas of non-complicated pregnancies of women delivered by spontaneous conception (SC) (n = 26) compared with those of ART (n = 26). Histological and morphometric assessment of fetal chorionic villi as well as the expression of various adhesive molecules (ICAM-1, VCAM-1 and PECAM-1) were performed in fetal plasma and placenta.
  
  
  
  Although we did not observe any obvious changes in the histological structure of placenta of ART pregnancies, it showed a significant (p < 0.05) decrease in the syncytiotrophoblast cytoplasmic area accompanied with a significant increase (p < 0.05) in the vessel area and syncytiotrophoblast nuclear area without remarkable change in the total villous area or total syncytiotrophoblast % area. In addition, almost all levels of the assayed adhesive molecules were significantly increased (p < 0.05) in placenta as well as in fetal plasma of ART pregnancies compared with SC.
  
  
  
  We suggested in the current study that the altered adhesive molecules expression accompanying the increased vessel area and decreased syncytial cytoplasm area may indicate a subclinical endothelial stress in placenta of non-complicated ART pregnancies.
authors.affiliation: Department of Histology and Cell Biology, Faculty of Medicine, Mansoura University, Egypt. Electronic address: profahmadpasha@mans.edu.eg.
authors.forename: Ahmed A M
authors.initials: AA
authors.lastname: Abdel-Hamid
authors.affiliation: Department of Histology and Cell Biology, Faculty of Medicine, Mansoura University, Egypt.
authors.forename: Alaa El-Din L
authors.initials: AE
authors.lastname: Firgany
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, Mansoura University, Egypt.
authors.forename: Yaser
authors.initials: Y
authors.lastname: Mesbah
authors.affiliation: Department of Histology and Cell Biology, Faculty of Medicine, Mansoura University, Egypt.
authors.forename: Mona F M
authors.initials: MF
authors.lastname: Soliman
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002824:Chorionic Villi / Q000033:anatomy & histology / Q000378:metabolism*; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism*; D010920:Placenta / Q000033:anatomy & histology / Q000378:metabolism*; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000378:metabolism*; D011247:Pregnancy; D027724:Reproductive Techniques, Assisted; D014327:Trophoblasts / Q000378:metabolism; D019010:Vascular Cell Adhesion Molecule-1 / Q000378:metabolism*
chemical_list: C573420:ICAM1 protein, human; D019408:Platelet Endothelial Cell Adhesion Molecule-1; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1
keywords: ART; ICAM-1; Non-complicated pregnancy; PECAM; Placenta; VCAM-1