title: Eosinophilic meningomyelitis associated with T-cell lymphoma in a cat.
abstract: A 12-year-old cat was presented for evaluation of progressive tetraparesis. Magnetic resonance imaging of the cervical spine demonstrated T2-hyperintensity, and contrast enhancement within the C4-C7 spinal cord, with marked meningeal contrast enhancement and segmental nerve root thickening. Lumbar cerebrospinal fluid contained 407 total nucleated cells/μL, with 99% eosinophils. The cat transiently improved with prednisolone, clindamycin, and ivermectin therapy, but subsequently worsened and was euthanized. Necropsy revealed an asymmetric infiltration predominantly of the white matter, meninges, and nerve roots of the C4-C6 spinal cord segments by an unencapsulated, poorly demarcated neoplasm composed of atypical lymphocytes admixed with eosinophils, causing perivascular hemorrhage and lytic necrosis. The neoplastic cells were immunoreactive for CD3, ultimately confirming T-cell lymphoma.
authors.affiliation: Department of Clinical Sciences, North Carolina State University, Raleigh, NC, USA.
authors.forename: Kathryn Y
authors.initials: KY
authors.lastname: Bray
authors.affiliation: Department of Clinical Sciences, North Carolina State University, Raleigh, NC, USA.
authors.forename: Karen R
authors.initials: KR
authors.lastname: Muñana
authors.affiliation: Department of Population Health and Pathobiology, North Carolina State University, Raleigh, NC, USA.
authors.forename: Kristina
authors.initials: K
authors.lastname: Meichner
authors.affiliation: Department of Population Health and Pathobiology, North Carolina State University, Raleigh, NC, USA.
authors.forename: Laura A
authors.initials: LA
authors.lastname: White
authors.affiliation: Department of Clinical Sciences, North Carolina State University, Raleigh, NC, USA.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Seiler
mesh_terms: D000818:Animals; D017252:CD3 Complex / Q000276:immunology*; D002371:Cat Diseases / Q000134:cerebrospinal fluid / Q000000981:diagnostic imaging / Q000473:pathology; D002415:Cats; D066193:Cervical Cord / Q000000981:diagnostic imaging / Q000473:pathology; D004804:Eosinophils / Q000473:pathology; D007249:Inflammation / Q000662:veterinary; D007964:Leukocytosis / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D016399:Lymphoma, T-Cell / Q000134:cerebrospinal fluid / Q000000981:diagnostic imaging / Q000473:pathology / Q000662:veterinary*; D008279:Magnetic Resonance Imaging / Q000662:veterinary; D008297:Male
chemical_list: D017252:CD3 Complex
keywords: Cerebrospinal fluid; eosinophilic pleocytosis; feline; neoplasia; tetraparesis