title: Hemicrania Continua: Beneficial Effect of Non-Invasive Vagus Nerve Stimulation in a Patient With a Contraindication for Indomethacin.
abstract: Hemicrania continua (HC) is a primary chronic headache disorder, characterized by a continuous and strictly unilateral headache, with possible cranial autonomic symptoms during episodes of pain exacerbation. The unilateral headache generally responds well to indomethacin; however, continuous indomethacin intake is often not tolerated due to severe adverse effects, like hypertension, gastrointestinal discomfort (especially if combined with aspirin), slightly increased risk of vascular events, and bronchial spasms. Therefore, alternative treatment options are desperately needed. Non-invasive vagus nerve stimulation (nVNS) has been shown to be effective in patients with cluster headache, another trigeminal autonomic cephalalgia (TAC), with cranial parasympathetic autonomic activation during the attacks.
authors.affiliation: Klinikum der Universität München - Neurologische Klinik und Poliklinik & Deutsches Schwindel- und Gleichgewichtszentrum DSGZ, Munich, Germany.
authors.forename: Ozan
authors.identifier: http://orcid.org/0000-0002-5299-388X
authors.initials: O
authors.lastname: Eren
authors.affiliation: Klinikum der Universität München - Neurologische Klinik und Poliklinik & Deutsches Schwindel- und Gleichgewichtszentrum DSGZ, Munich, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Straube
authors.affiliation: Klinikum der Universität München - Neurologische Klinik und Poliklinik & Deutsches Schwindel- und Gleichgewichtszentrum DSGZ, Munich, Germany.
authors.forename: Florian
authors.initials: F
authors.lastname: Schöberl
authors.affiliation: Klinikum der Universität München - Neurologische Klinik und Poliklinik & Deutsches Schwindel- und Gleichgewichtszentrum DSGZ, Munich, Germany.|Department of Neurology, University of Bern, Inselspital, Bern, Switzerland.
authors.forename: Christoph
authors.initials: C
authors.lastname: Schankin
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000627:therapeutic use; D051270:Headache Disorders, Primary / Q000150:complications / Q000628:therapy*; D006801:Humans; D007213:Indomethacin / Q000009:adverse effects / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications; D055536:Vagus Nerve Stimulation
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D007213:Indomethacin
keywords: gammaCore; hemicrania continua; indomethacin contraindication; neuromodulation; non-invasive vagus nerve stimulation; treatment