title: Genetic polymorphisms of glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) and susceptibility to pre-eclampsia: a case-control study and a meta-analysis.
abstract: The objective of the present hospital-based case-control study was to assess the association between glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) genetic polymorphisms and susceptibility to pre-eclampsia (PE) in Shiraz (Fars province, southern Iran). A total of 200 healthy pregnant women and 151 pre-eclamptic women were included. The healthy control group was frequency matched with the age of the pre-eclamptic women. Control women had neither PE in current pregnancy nor history of pregnancies with PE previously. The genotypes ofGSTT1andGSTM1polymorphisms were determined using a PCR-based method. NeitherGSTM1null genotype (OR=1.07, 95 % CI: 0.70-1.64, P=0.736) norGSTT1null genotype (OR=0.73, 95 % CI: 0.44-1.21, P=0.233) was associated with risk of PE. Association between combination genotypes and risk of PE was not significant. When family history was entered as a covariate in analysis, adjusted ORs revealed that neitherGSTM1norGSTT1polymorphisms was associated with risk of PE. For meta-analysis, we identified 5 eligible studies, including 1217 subjects (515 patients, and 702 healthy controls) in relation to the study polymorphisms and risk of PE. Our present meta-analysis indicated that there neitherGSTM1(OR=0.99, 95 % CI: 0.78-1.25, P=0.955) norGSTT1polymorphisms (OR=0.85, 95 % CI: 0.66-1.10, P=0.223) was associated with susceptibility to PE. Taken together it seems that the polymorphisms ofGSTM1andGSTT1are not risk factors for PE. Further investigations adjusting for confounding factors are needed to confirm the present findings.
authors.affiliation: Department of Biology, College of Sciences, Shiraz University, Shiraz 71454, Iran.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Anvar
authors.affiliation: Department of Biology, College of Sciences, Shiraz University, Shiraz 71454, Iran.
authors.forename: Iraj
authors.initials: I
authors.lastname: Saadat
authors.affiliation: Department of OB-GYN, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Bahia
authors.initials: B
authors.lastname: Namavar-Jahromi
authors.affiliation: Department of Biology, College of Sciences, Shiraz University, Shiraz 71454, Iran.
authors.forename: Mostafa
authors.initials: M
authors.lastname: Saadat
keywords: GSTM1; GSTT1; meta-analysis; polymorphism; pre-eclampsia