title: Macular function in preterm children at school age.
abstract: OBJECTIVE
  Macular development is a complex process that starts by mid-gestation and continues several years after birth. A preterm birth could affect this development, causing increased thickness in the central macula, but the effect of the macular function remains uncertain. The aim of this study was to investigate the macular function measured with multifocal electroretinography (mfERG), in former preterm children and compare with healthy controls. A second aim was to correlate central macular function with central macular thickness measured with optical coherent tomography (OCT), in the preterm group.
  
  
  METHODS
  Fifteen former preterm children born before 32 weeks of gestation were included in the study. MfERG results from 12 children acted as controls. Visual acuity, refraction in cycloplegia and mfERG were carried out in all children, and optical coherent tomography (OCT) was performed in the preterm children. Main outcomes were P1 amplitudes and implicit times for Rings 1-5 and "sum of groups" of the mfERG, and central macula thickness in area A1 measured with OCT.
  
  
  RESULTS
  The P1 amplitudes were reduced in Rings 1-5 and "Sum of groups" in the preterm children compared to controls. There were no significant correlation between P1 amplitude or implicit times in Ring 1 and central macular thickness in the preterm group.
  
  
  CONCLUSIONS
  Macular function is reduced in former preterm children compared to children born at term. This suggests that the structural changes with a thicker central retina can have an effect on function and may be one, of probably several, explanations for visual dysfunction in preterm children at school age.
authors.affiliation: Department of Neuroscience/Ophthalmology, Uppsala University, 751 24, Uppsala, Sweden. hannamcarlsson@hotmail.com.
authors.forename: Hanna
authors.identifier: http://orcid.org/0000-0002-4041-8482
authors.initials: H
authors.lastname: Åkerblom
authors.affiliation: Department of Ophthalmology, Lund University Hospital, 221 85, Lund, Sweden.
authors.forename: Sten
authors.initials: S
authors.lastname: Andreasson
authors.affiliation: Department of Neuroscience/Ophthalmology, Uppsala University, 751 24, Uppsala, Sweden.
authors.forename: Gerd
authors.initials: G
authors.lastname: Holmström
mesh_terms: D000293:Adolescent; D002648:Child; D004596:Electroretinography / Q000379:methods*; D005260:Female; D005865:Gestational Age; D006801:Humans; D007234:Infant, Premature / Q000502:physiology*; D008266:Macula Lutea / Q000502:physiology* / Q000503:physiopathology; D008297:Male; D041623:Tomography, Optical Coherence / Q000379:methods; D014792:Visual Acuity / Q000502:physiology
keywords: Macula; Multifocal electroretinogram (mfERG); Optical coherent tomography (OCT); Preterm children