title: Magneto-Plasmonic Janus Vesicles for Magnetic Field-Enhanced Photoacoustic and Magnetic Resonance Imaging of Tumors.
abstract: Magneto-plasmonic Janus vesicles (JVs) integrated with gold nanoparticles (AuNPs) and magnetic NPs (MNPs) were prepared asymmetrically in the membrane for in vivo cancer imaging. The hybrid JVs were produced by coassembling a mixture of hydrophobic MNPs, free amphiphilic block copolymers (BCPs), and AuNPs tethered with amphiphilic BCPs. Depending on the size and content of NPs, the JVs acquired spherical or hemispherical shapes. Among them, hemispherical JVs containing 50 nm AuNPs and 15 nm MNPs showed a strong absorption in the near-infrared (NIR) window and enhanced the transverse relaxation (T2) contrast effect, as a result of the ordering and dense packing of AuNPs and MNPs in the membrane. The magneto-plasmonic JVs were used as drug delivery vehicles, from which the release of a payload can be triggered by NIR light and the release rate can be modulated by a magnetic field. Moreover, the JVs were applied as imaging agents for in vivo bimodal photoacoustic (PA) and magnetic resonance (MR) imaging of tumors by intravenous injection. With an external magnetic field, the accumulation of the JVs in tumors was significantly increased, leading to a signal enhancement of approximately 2-3 times in the PA and MR imaging, compared with control groups without a magnetic field.
authors.affiliation: Department of Chemistry and Biochemistry, University of Maryland, College Park, MD, 20742, USA.|Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health, USA.|Trans-NIH Shared Resource on Biomedical Engineering and Physical Science (BEPS), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health, USA.
authors.forename: Yijing
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health, USA.|Trans-NIH Shared Resource on Biomedical Engineering and Physical Science (BEPS), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health, USA.
authors.forename: Xiangyu
authors.initials: X
authors.lastname: Yang
authors.affiliation: Department of Chemistry and Biochemistry, University of Maryland, College Park, MD, 20742, USA.
authors.forename: Zhiqi
authors.initials: Z
authors.lastname: Huang
authors.affiliation: Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Shenzhen University, Shenzhen, 518060, P.R. China.
authors.forename: Peng
authors.initials: P
authors.lastname: Huang
authors.affiliation: Smart Hybrid Materials (SHMs) Lab, Department of Chemical Sciences and Engineering, Advanced Membranes and Porous Materials Center, King Abdullah University of Science and Technology (KAUST), Thuwal, 23955-6900, Kingdom of Saudi Arabia.
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Smart Hybrid Materials (SHMs) Lab, Department of Chemical Sciences and Engineering, Advanced Membranes and Porous Materials Center, King Abdullah University of Science and Technology (KAUST), Thuwal, 23955-6900, Kingdom of Saudi Arabia.
authors.forename: Lin
authors.initials: L
authors.lastname: Deng
authors.affiliation: Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health, USA.|Trans-NIH Shared Resource on Biomedical Engineering and Physical Science (BEPS), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health, USA.
authors.forename: Zhantong
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health, USA.|Trans-NIH Shared Resource on Biomedical Engineering and Physical Science (BEPS), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health, USA.
authors.forename: Zijian
authors.initials: Z
authors.lastname: Zhou
authors.affiliation: Department of Chemistry and Biochemistry, University of Maryland, College Park, MD, 20742, USA.
authors.forename: Yi
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health, USA.|Trans-NIH Shared Resource on Biomedical Engineering and Physical Science (BEPS), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health, USA.
authors.forename: Heather
authors.initials: H
authors.lastname: Kalish
authors.affiliation: Smart Hybrid Materials (SHMs) Lab, Department of Chemical Sciences and Engineering, Advanced Membranes and Porous Materials Center, King Abdullah University of Science and Technology (KAUST), Thuwal, 23955-6900, Kingdom of Saudi Arabia.
authors.forename: Niveen M
authors.initials: NM
authors.lastname: Khachab
authors.affiliation: Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health, USA.|Trans-NIH Shared Resource on Biomedical Engineering and Physical Science (BEPS), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health, USA.
authors.forename: Xiaoyuan
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Chemistry and Biochemistry, University of Maryland, College Park, MD, 20742, USA.
authors.forename: Zhihong
authors.identifier: 0000-0001-9639-905X
authors.initials: Z
authors.lastname: Nie
mesh_terms: D000818:Animals; D006046:Gold / Q000737:chemistry*; D006801:Humans; D060526:Magnetic Fields; D008279:Magnetic Resonance Imaging; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry*; D009369:Neoplasms / Q000000981:diagnostic imaging*; D010316:Particle Size; D055668:Photochemical Processes; D011092:Polyethylene Glycols / Q000737:chemistry; D011137:Polystyrenes / Q000737:chemistry
chemical_list: D058185:Magnetite Nanoparticles; D011137:Polystyrenes; C541965:polystyrene-b-poly(ethylene oxide); D011092:Polyethylene Glycols; D006046:Gold
keywords: Janus vesicles; magnetic resonance imaging; nanoparticles; photoacoustic imaging; self-assembly