title: Value of MR elastography for the preoperative estimation of liver regeneration capacity in patients with hepatocellular carcinoma.
abstract: To demonstrate the negative relationship between liver stiffness (LS) values measured at preoperative magnetic resonance elastography (MRE) and the regeneration capacity of the remnant liver after major hepatectomy, in patients with hepatocellular carcinoma (HCC).
  
  
  
  Thirty-eight patients with HCC (mean age, 57.1) who had undergone liver computed tomography (CT) and 1.5T MRE prior to right hepatectomy were included in this retrospective study. CT volumetric analysis of total functional liver (calculated by subtracting tumor volume from total liver volume), future liver remnant (FLR), and postoperative liver remnant (LR) were performed using a semiautomatic analysis program. The regeneration index was expressed as [(VLR-VFLR)/VFLR] × 100, where VLRis the volume of the liver remnant and VFLRis the volume of the FLR. The relationship between degree of LS measured at MRE and the regeneration index was assessed using the Spearman correlation test.
  
  
  
  Average LS value at MRE increased along with hepatic fibrosis (HF) stage (r = 0.604, P < 0.001). At MRE, a cutoff value greater than 2.46 kPa yielded 90.0% sensitivity and 100% specificity in identifying HF stage 2 or greater (area under the curve [AUC], 0.95). Mean VFLRand VLRwere 477.1 ± 147.5 mL and 911.9 ± 188.8 mL, respectively. The regeneration index of the liver remnant was 102.1 ± 58.2%. LS values at MRE and calculated regeneration index after right hepatectomy showed moderate negative correlation (r = -0.361, P = 0.026).
  
  
  
  LS values measured at MRE may serve as a postoperative predictor of liver regeneration in patients with liver cirrhosis and HCC.
  
  
  
  4 Technical Efficacy: Stage 2 J. MAGN. RESON. IMAGING 2017;45:1627-1636.
authors.affiliation: Department of Radiology, Seoul National University Hospital and Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Siwon
authors.identifier: 0000-0002-6980-431X
authors.initials: S
authors.lastname: Jang
authors.affiliation: Department of Radiology, Seoul National University Hospital and Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Jeong Min
authors.initials: JM
authors.lastname: Lee
authors.affiliation: Department of Radiology, Seoul National University Hospital and Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Dong Ho
authors.initials: DH
authors.lastname: Lee
authors.affiliation: Department of Radiology, Seoul National University Hospital and Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Ijin
authors.initials: I
authors.lastname: Joo
authors.affiliation: Department of Radiology, Seoul National University Hospital and Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Jeong Hee
authors.initials: JH
authors.lastname: Yoon
authors.affiliation: Department of Radiology, Seoul National University Hospital and Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Won
authors.initials: W
authors.lastname: Chang
authors.affiliation: Department of Radiology, Seoul National University Hospital and Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Joon Koo
authors.initials: JK
authors.lastname: Han
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000150:complications / Q000000981:diagnostic imaging* / Q000601:surgery*; D054459:Elasticity Imaging Techniques / Q000379:methods*; D005260:Female; D006498:Hepatectomy; D006801:Humans; D008103:Liver Cirrhosis / Q000000981:diagnostic imaging / Q000209:etiology / Q000601:surgery; D008113:Liver Neoplasms / Q000150:complications / Q000000981:diagnostic imaging* / Q000601:surgery*; D008115:Liver Regeneration; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011300:Preoperative Care / Q000379:methods; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D016896:Treatment Outcome
keywords: MR elastography; hepatocellular carcinoma; liver stiffness; postoperative liver regeneration