title: Parathyroidectomy for primary hyperparathyroidism improves sleep quality: A prospective study.
abstract: This prospective survey study assessed changes in sleep quality in patients with primary hyperparathyroidism after parathyroidectomy.
  
  
  
  Patients undergoing parathyroidectomy for primary hyperparathyroidism (n = 110) or thyroidectomy for benign euthyroid disease (control group; n = 45) were recruited between June 2013 and June 2015 and completed the Pittsburgh Sleep Quality Index preoperatively and at 1- and 6 months postoperatively. "Poor" sleep quality was defined as a score >5; a clinically important and relevant improvement was a ≥3-point decrease.
  
  
  
  Preoperatively, parathyroid patients had worse sleep quality than thyroid patients (mean 8.1 vs 5.3; P < .001); 76 (69%) parathyroid and 23 (51%) thyroid patients reported poor sleep quality (P = .03). Postoperatively, only parathyroid patients demonstrated improvement in sleep quality; mean scores did not differ between the parathyroid and thyroid groups at 1 month (6.3 vs 5.3; P = .12) or 6 months (5.8 vs 4.6; P = .11). The proportion of patients with a clinically important improvement in sleep quality was greater in the parathyroid group at 1 month (37% vs 10%; P < .001) and 6 months (40% vs 17%; P = .01). Importantly, there was no difference in the proportion of patients with poor sleep quality between the 2 groups at 1 month (50% vs 40%; P = .32) and 6 months (40% vs 29%; P = .22).
  
  
  
  More than two-thirds of patients with primary hyperparathyroidism report poor sleep quality. After parathyroidectomy, over one-third experienced improvement, typically within the first month postoperatively.
authors.affiliation: Department of Surgery, Medical College of Wisconsin, Milwaukee, WI.
authors.forename: Justin
authors.initials: J
authors.lastname: La
authors.affiliation: Department of Surgery, Medical College of Wisconsin, Milwaukee, WI.
authors.forename: Tracy S
authors.initials: TS
authors.lastname: Wang
authors.affiliation: Department of Surgery, Medical College of Wisconsin, Milwaukee, WI.
authors.forename: Abdulrahman Y
authors.initials: AY
authors.lastname: Hammad
authors.affiliation: Department of Surgery, Medical College of Wisconsin, Milwaukee, WI.
authors.forename: Laura
authors.initials: L
authors.lastname: Burgardt
authors.affiliation: Department of Surgery, Medical College of Wisconsin, Milwaukee, WI.
authors.forename: Kara
authors.initials: K
authors.lastname: Doffek
authors.affiliation: Department of Surgery, Medical College of Wisconsin, Milwaukee, WI.
authors.forename: Azadeh A
authors.initials: AA
authors.lastname: Carr
authors.affiliation: Department of Medicine, Medical College of Wisconsin, Milwaukee, WI.
authors.forename: Joseph L
authors.initials: JL
authors.lastname: Shaker
authors.affiliation: Department of Medicine, Medical College of Wisconsin, Milwaukee, WI.
authors.forename: Ty B
authors.initials: TB
authors.lastname: Carroll
authors.affiliation: Department of Surgery, Medical College of Wisconsin, Milwaukee, WI.
authors.forename: Douglas B
authors.initials: DB
authors.lastname: Evans
authors.affiliation: Department of Surgery, Medical College of Wisconsin, Milwaukee, WI. Electronic address: tyen@mcw.edu.
authors.forename: Tina W F
authors.initials: TW
authors.lastname: Yen
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D049950:Hyperparathyroidism, Primary / Q000150:complications / Q000175:diagnosis / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D016105:Parathyroidectomy / Q000379:methods*; D017286:Polysomnography / Q000379:methods; D011184:Postoperative Period; D011446:Prospective Studies; D011788:Quality of Life; D012016:Reference Values; D012720:Severity of Illness Index; D012890:Sleep / Q000502:physiology*; D012893:Sleep Wake Disorders / Q000209:etiology / Q000517:prevention & control*; D013965:Thyroidectomy / Q000379:methods