title: Novel approaches toward the generation of bioscaffolds as a potential therapy in cardiovascular tissue engineering.
abstract: Cardiovascular disease associated with myocardial infarction (MI) is among the leading causes of mortality worldwide, in part, due to the limited regenerative capacity of tissues. Although various approaches have been employed to generate bioartificial myocardial tissues, including surgical reconstruction and the use of biosynthetic or biological cell-free grafts, many challenges still remain. Natural biomaterials based on decellularization have made significant inroads into the development of favorable biomatrices for myocardial tissue regeneration. This process occurs with the concept of removing whole cellular contents, while preserving the extracellular matrix components and all the necessary features of native tissues. Furthermore, acellular-derived matrices serve to stimulate proliferation and recruitment of endothelial cells by providing proliferation signals to cells. This review highlights a novel approach to generate natural three dimensional myocardial scaffolds for clinical applications.
authors.affiliation: National Cell Bank of Iran, Pasteur Institute of Iran, Tehran, Iran; Department of Medical Biotechnology, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Fahimeh
authors.initials: F
authors.lastname: Shahabipour
authors.affiliation: Department of Hypertension, WAM University Hospital in Lodz, Medical University of Lodz, Zeromskiego 113, Lodz, Poland.
authors.forename: Maciej
authors.initials: M
authors.lastname: Banach
authors.affiliation: Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, Kansas City, MO, USA.
authors.forename: Thomas P
authors.initials: TP
authors.lastname: Johnston
authors.affiliation: Unit of Internal Medicine, Angiology and Arteriosclerosis Diseases, Department of Medicine, University of Perugia, Perugia, Italy.
authors.forename: Matteo
authors.initials: M
authors.lastname: Pirro
authors.affiliation: Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad 9177948564, Iran; Metabolic Research Centre, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Australia. Electronic address: sahebkara@mums.ac.ir.
authors.forename: Amirhossein
authors.initials: A
authors.lastname: Sahebkar
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000627:therapeutic use*; D002318:Cardiovascular Diseases / Q000601:surgery*; D005544:Forecasting; D006801:Humans; D012680:Sensitivity and Specificity; D013552:Swine; D023822:Tissue Engineering / Q000379:methods* / Q000639:trends; D054457:Tissue Scaffolds
chemical_list: D001672:Biocompatible Materials
keywords: Bioscaffold; Cardiovascular disease; Decellularized matrix; Myocardial infarction; Tissue engineering