title: Visceral adiposity index levels in overweight and/or obese, and non-obese patients with polycystic ovary syndrome and its relationship with metabolic and inflammatory parameters.
abstract: BACKGROUND
  Visceral adiposity index (VAI) is a proposed parameter to evaluate visceral obesity instead of waist circumference (WC) in patients with polycystic ovary syndrome (PCOS). We aimed to evaluate VAI levels in overweight and/or obese, and non-obese PCOS patients and investigate the association between metabolic and inflammatory parameters.
  
  
  METHODS
  Seventy-six PCOS patients between 18 and 40, and 38 age- and BMI-matched controls were enrolled into the study. Both PCOS groups and controls were classified into two subgroups according to body mass index (BMI) <25 and ≥25 kg/m2.
  
  
  RESULTS
  In PCOS patients, waist/hip ratio (WHR) (p = 0.023), diastolic blood pressure (DBP) (p = 0.001), insulin (p = 0.011), homeostasis of model assessment (HOMA-IR) (p = 0.006) and uric acid (UA) (p = 0.002) were higher than controls. In overweight and/or obese PCOS group, DBP (p < 0.001), insulin (p = 0.002), HOMA-IR (p = 0.001), triglyceride (p = 0.015) and VAI (p = 0.031) were higher than overweight and/or obese controls. In non-obese PCOS group, WHR (p = 0.016), WC (p = 0.030), DBP (p = 0.010) and UA (p < 0.001) were higher than non-obese controls. Similar VAI levels were found in all PCOS and non-obese PCOS subgroups than peer controls. Overweight and/or obese PCOS group had higher VAI levels than non-obese PCOS group (p < 0.001). VAI levels were positively correlated with WHR, glucose, HOMA-IR, high-sensitive CRP and UA in PCOS group. In controls, VAI levels were positively correlated with WHR, insulin and HOMA-IR.
  
  
  CONCLUSIONS
  We found that VAI levels were higher in overweight and/or obese PCOS patients compared to peer controls and non-obese PCOS patients, and associated with some metabolic and inflammatory parameters.
authors.affiliation: Department of Internal Medicine, Konya Health Application and Research Center, University of Health Sciences, Meram Yeniyol, Meram, 42100, Konya, Turkey.
authors.forename: U
authors.initials: U
authors.lastname: Durmus
authors.affiliation: Division of Endocrinology and Internal Medicine, Konya Health Application and Research Center, University of Health Sciences, Meram Yeniyol, Meram, 42100, Konya, Turkey. drcduran@gmail.com.
authors.forename: C
authors.initials: C
authors.lastname: Duran
authors.affiliation: Department of Internal Medicine, Konya Health Application and Research Center, University of Health Sciences, Meram Yeniyol, Meram, 42100, Konya, Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Ecirli
mesh_terms: D050154:Adiposity; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007249:Inflammation / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D018836:Inflammation Mediators / Q000378:metabolism; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008297:Male; D056128:Obesity, Abdominal / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D050177:Overweight / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D011379:Prognosis; D011446:Prospective Studies; D055105:Waist Circumference; D049629:Waist-Hip Ratio; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D018836:Inflammation Mediators; D007328:Insulin
keywords: High-sensitive CRP; Insulin resistance; Polycystic ovary syndrome; Uric acid; Visceral adiposity index; Waist circumference