title: [ANMCO position paper: Use of new oral anticoagulants for the treatment and prevention of pulmonary thromboembolism].
abstract: The new oral anticoagulants (NOACs) have radically changed the approach to the treatment and prevention of thromboembolic pulmonary embolism. The authors of this position paper face, in succession, issues concerning NOACs, including 1) their mechanism of action, pharmacodynamics and pharmacokinetics; 2) the use in the acute phase with the "double drug single dose" approach or with "single drug double dose"; 3) the use in the extended phase with demonstrated efficacy and with low incidence of bleeding events; 4) the encouraging use of NOACs in particular subgroups of patients such as those with cancer, the ones under- or overweight, with renal insufficiency (creatinine clearance >30 ml/min), the elderly (>75 years); 5) they propose a possible laboratory clinical pathway for follow-up; 6) carry out an examination on the main drug interactions, their potential bleeding risk, and the way to deal with some bleeding complications. The authors conclude that the use of NOACs both in the acute phase and in the extended phase is equally effective to conventional therapy and associated with fewer major bleeding events, which make their use in patients at higher risk of recurrences safer.
authors.affiliation: U.O.C. Medicina d'Urgenza, A.O.R.N. S. Anna e S. Sebastiano, Caserta.
authors.forename: Iolanda
authors.initials: I
authors.lastname: Enea
authors.affiliation: U.O.C. Cardiologia, Ospedale S. Maria della Misericordia, Rovigo.
authors.forename: Loris
authors.initials: L
authors.lastname: Roncon
authors.affiliation: U.O.C. Cardiologia, Ospedale Garibaldi-Nesima, Azienda di Rilievo Nazionale e Alta Specializzazione "Garibaldi", Catania.
authors.forename: Michele Massimo
authors.initials: MM
authors.lastname: Gulizia
authors.affiliation: Servizio di Cardiologia, Ospedale San Carlo di Nancy, Roma.
authors.forename: Michele
authors.initials: M
authors.lastname: Azzarito
authors.affiliation: Medicina Interna e Vascolare, Azienda Ospedaliera di Perugia, Perugia.
authors.forename: Cecilia
authors.initials: C
authors.lastname: Becattini
authors.affiliation: U.O.C. Cardiologia, Ospedale San Carlo Borromeo, Milano.
authors.forename: Amedeo
authors.initials: A
authors.lastname: Bongarzoni
authors.affiliation: Fondazione Moscati, Buccinasco (MI).
authors.forename: Franco
authors.initials: F
authors.lastname: Casazza
authors.affiliation: U.O. Cardiologia, Istituto Ospedaliero Fondazione Poliambulanza, Brescia.
authors.forename: Claudio
authors.initials: C
authors.lastname: Cuccia
authors.affiliation: U.O.C. Cardiologia Ospedaliera, Azienda Ospedaliero-Universitaria Policlinico, Bari.
authors.forename: Carlo
authors.initials: C
authors.lastname: D'Agostino
authors.affiliation: U.O.C. Cardiologia, Ospedale Ca' Foncello, Treviso.
authors.forename: Matteo
authors.initials: M
authors.lastname: Rugolotto
authors.affiliation: UTIC-Emodinamica e Cardiologia Interventistica, Ospedale Civile Pugliese, Catanzaro.
authors.forename: Marco
authors.initials: M
authors.lastname: Vatrano
authors.affiliation: U.O.C. Cardiologia-UTIC, Ospedale Umberto I, Siracusa.
authors.forename: Eugenio
authors.initials: E
authors.lastname: Vinci
authors.affiliation: U.O. Nefrologia e Dialisi, IRCCS Fondazione Salvatore Maugeri, Università degli Studi, Pavia.
authors.forename: Paride
authors.initials: P
authors.lastname: Fenaroli
authors.affiliation: Cardiologia Interventistica-UTIC, A.O. G. Rummo, Benevento.
authors.forename: Dario
authors.initials: D
authors.lastname: Formigli
authors.affiliation: Cardiologia Interventistica-UTIC, A.O. G. Rummo, Benevento.
authors.forename: Paolo
authors.initials: P
authors.lastname: Silvestri
authors.affiliation: S.O.C. Cardiologia, Ospedale Castelli, Verbania.
authors.forename: Federico
authors.initials: F
authors.lastname: Nardi
authors.affiliation: Medicina Interna e Vascolare, Ospedale S. Maria della Misericordia, Università degli Studi, Perugia.
authors.forename: Maria Cristina
authors.initials: MC
authors.lastname: Vedovati
authors.affiliation: Cardiologia Interventistica-UTIC, A.O. G. Rummo, Benevento.
authors.forename: Marino
authors.initials: M
authors.lastname: Scherillo
mesh_terms: D000284:Administration, Oral; D000368:Aged; D000925:Anticoagulants / Q000008:administration & dosage*; D006470:Hemorrhage; D006801:Humans; D011655:Pulmonary Embolism; D013923:Thromboembolism / Q000188:drug therapy / Q000517:prevention & control*; D054556:Venous Thromboembolism
chemical_list: D000925:Anticoagulants