title: UNRelenting Translation UNRestrains Melanoma Migration.
abstract: The cytoplasmic RNA-binding protein UNR influences key developmental processes by controlling mRNA turnover and translation initiation. In this issue of Cancer Cell, Wurth et al. report that UNR is highly expressed in melanoma and enhances invasion and metastasis at least partly by inducing translation elongation of VIM and RAC1 mRNAs.
authors.affiliation: Tumor Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, PA 19104, USA.
authors.forename: Ashani T
authors.initials: AT
authors.lastname: Weeraratna
authors.affiliation: Laboratory of Genetics and Genomics, National Institute on Aging-IRP, National Institutes of Health, Baltimore, MD 21224, USA. Electronic address: myriam-gorospe@nih.gov.
authors.forename: Myriam
authors.initials: M
authors.lastname: Gorospe
mesh_terms: D004268:DNA-Binding Proteins / Q000235:genetics*; D006801:Humans; D008545:Melanoma; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000378:metabolism; D016601:RNA-Binding Proteins / Q000235:genetics*
chemical_list: D004268:DNA-Binding Proteins; D012333:RNA, Messenger; D016601:RNA-Binding Proteins