title: Ethanol induced antidepressant-like effect in the mouse forced swimming test: modulation by serotonergic system.
abstract: The present investigation explored the modulatory role of serotonergic transmission in the acute ethanol-induced effects on immobility time in the mouse forced swim test (FST).
  
  
  
  Acute i.p. administration of ethanol (20% w/v, 2 or 2.5 g/kg, i.p.) decreased the immobility time in FST of mice, indicating its antidepressant-like effect while lower doses of ethanol (1, 1.5 g/kg, i.p.) were devoid of any effect in the FST. The mice pre-treated with a sub-effective dose of 5-HT2Aagonist, DOI (10 μg/mouse, i.c.v.) or 5-HT1Areceptor antagonist, WAY 100635 (0.1 μg/mouse, i.c.v.) but not with the 5-HT2A/2Cantagonist, ketanserin (1.5 μg/mouse, i.c.v.) exhibited a synergistic reduction in the immobility time induced by sub-effective dose of ethanol (1.5 g/kg, i.p.). On the other hand, ethanol (2.5 g/kg, i.p.) failed to decrease the immobility time in mice, pre-treated with 5-HT1Aagonist, 8-OH-DPAT (0.1 μg/mouse, i.c.v.) or ketanserin (1.5 μg/mouse, i.c.v.). In addition, pre-treatment with a 5-HT neuronal synthesis inhibitor, p-CPA (300 mg/kg, i.p. × 3 days) attenuated the anti-immobility effect ethanol (2.5 g/kg, i.p.) in mouse FST.
  
  
  
  Thus, the results of the present study points towards the essentiality of the central 5-HT transmission at the synapse for the ethanol-induced antidepressant-like effect in the FST wherein the regulatory role of the 5-HT1Areceptor or contributory role of the 5-HT2A/2Creceptor-mediated mechanism is proposed in the anti-immobility effect of acute ethanol in mouse FST.
authors.affiliation: Department of Pharmacology, Institute of Pharmaceutical Sciences, Guru Ghasidas University (A Central University), Koni, Bilaspur, 495009, Chhattisgarh, India. nishant.s.jain@hotmail.com.
authors.forename: Nishant S
authors.initials: NS
authors.lastname: Jain
authors.affiliation: Department of Pharmacology, J. L. Chaturvedi College of Pharmacy, Higna Road, MIDC, Nagpur, Maharashtra, India.
authors.forename: Uday
authors.initials: U
authors.lastname: Kannamwar
authors.affiliation: Department of Pharmacology, Institute of Pharmaceutical Sciences, Guru Ghasidas University (A Central University), Koni, Bilaspur, 495009, Chhattisgarh, India.
authors.forename: Lokesh
authors.initials: L
authors.lastname: Verma
mesh_terms: D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000494:pharmacology; D000662:Amphetamines / Q000494:pharmacology; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects*; D002492:Central Nervous System Depressants / Q000494:pharmacology*; D003863:Depression; D004357:Drug Synergism; D000431:Ethanol / Q000494:pharmacology*; D007650:Ketanserin / Q000494:pharmacology; D008297:Male; D051379:Mice; D044282:Receptor, Serotonin, 5-HT1A / Q000187:drug effects; D058825:Serotonin 5-HT1 Receptor Agonists / Q000494:pharmacology; D058829:Serotonin 5-HT1 Receptor Antagonists / Q000494:pharmacology; D058826:Serotonin 5-HT2 Receptor Agonists / Q000494:pharmacology; D058830:Serotonin 5-HT2 Receptor Antagonists / Q000494:pharmacology; D013550:Swimming
chemical_list: D000662:Amphetamines; D000928:Antidepressive Agents; D002492:Central Nervous System Depressants; D058825:Serotonin 5-HT1 Receptor Agonists; D058829:Serotonin 5-HT1 Receptor Antagonists; D058826:Serotonin 5-HT2 Receptor Agonists; D058830:Serotonin 5-HT2 Receptor Antagonists; D044282:Receptor, Serotonin, 5-HT1A; D000431:Ethanol; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D007650:Ketanserin; C015952:4-iodo-2,5-dimethoxyphenylisopropylamine
keywords: 5-HT; 5-HT1A receptor; 5-HT2A/2C receptor; Antidepressant-like effect; Ethanol; Forced swim test