title: Combinatorial nanodiamond in pharmaceutical and biomedical applications.
abstract: One of the newly emerging carbon materials, nanodiamond (ND), has been exploited for use in traditional electric materials and this has extended into biomedical and pharmaceutical applications. Recently, NDs have attained significant interests as a multifunctional and combinational drug delivery system. ND studies have provided insights into granting new potentials with their wide ranging surface chemistry, complex formation with biopolymers, and combination with biomolecules. The studies that have proved ND inertness, biocompatibility, and low toxicity have made NDs much more feasible for use in real in vivo applications. This review gives an understanding of NDs in biomedical engineering and pharmaceuticals, focusing on the classified introduction of ND/drug complexes. In addition, the diverse potential applications that can be obtained with chemical modification are presented.
authors.affiliation: College of Pharmacy, Dongguk University-Seoul, Gyeonggi, Republic of Korea.
authors.forename: Dae Gon
authors.initials: DG
authors.lastname: Lim
authors.affiliation: College of Pharmacy, Dongguk University-Seoul, Gyeonggi, Republic of Korea.
authors.forename: Racelly Ena
authors.initials: RE
authors.lastname: Prim
authors.affiliation: College of Pharmacy, Dongguk University-Seoul, Gyeonggi, Republic of Korea.
authors.forename: Ki Hyun
authors.initials: KH
authors.lastname: Kim
authors.affiliation: School of Chemical Engineering and Material Science, Chung-Ang University, 221 Heukseok-Dong, Dongjak-Gu, Seoul, Republic of Korea. Electronic address: eakangek@cau.ac.kr.
authors.forename: Eunah
authors.initials: E
authors.lastname: Kang
authors.affiliation: Departments of Pharmaceutics and Biomedical Engineering, Purdue University, West Lafayette, IN 47907, United States.
authors.forename: Kinam
authors.initials: K
authors.lastname: Park
authors.affiliation: College of Pharmacy, Dongguk University-Seoul, Gyeonggi, Republic of Korea. Electronic address: shjeong@dongguk.edu.
authors.forename: Seong Hoon
authors.initials: SH
authors.lastname: Jeong
mesh_terms: D001698:Biomedical Engineering / Q000379:methods; D002244:Carbon / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods*; D058612:Nanodiamonds / Q000737:chemistry*; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D058612:Nanodiamonds; D004364:Pharmaceutical Preparations; D002244:Carbon
keywords: Complex formation; Drug delivery; Nanodiamond; Surface