title: Cancer stem cell-targeted therapeutics and delivery strategies.
abstract: Cancer initiating or stem cells (CSCs) are a small population of cells in the tumor mass, which have been reported to be present in different types of cancers. CSCs usually reside within the tumor and are responsible for reoccurrence of cancer. The imprecise, inaccessible nature and increased efflux of conventional therapeutic drugs make these cells resistant to drugs. We discuss the specific markers for identification of these cells, role of CSCs in chemotherapy resistance and use of different therapeutic means to target them, including elucidation of specific cell markers, exploitation of different signaling pathways and use of nanotechnology. Area covered: This review covers cancer stem cell signaling which are used by these cells to maintain their quiescence, stemness and resistant phenotype, distinct cell surface markers, contribution of these cells in drug resistance, inevitability to cure cancer and use of nanotechnology to overcome this hurdle. Expert opinion: Cancer stem cells are the main culprit of our failure to cure cancer. In order to cure cancer along with other cells types in cancer, cancer stem cells need to be targeted in the tumor bed. Nanotechnology solutions can facilitate clinical translation of the therapeutics along with other emerging technologies to cure cancer.
authors.affiliation: a Department of Pharmaceutical Sciences, School of Pharmacy , Northeastern University , Boston , MA , USA.
authors.forename: Gulzar
authors.initials: G
authors.lastname: Ahmad
authors.affiliation: a Department of Pharmaceutical Sciences, School of Pharmacy , Northeastern University , Boston , MA , USA.|b Faculty of Pharmacy , King Abdulaziz University , Jeddah , Saudi Arabia.
authors.forename: Mansoor M
authors.initials: MM
authors.lastname: Amiji
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D016503:Drug Delivery Systems; D019008:Drug Resistance, Neoplasm / Q000187:drug effects; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy; D014411:Neoplastic Stem Cells / Q000187:drug effects* / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D000970:Antineoplastic Agents
keywords: Cancer stem cells; nanotechnology; targeted delivery; therapeutic targets; tumor resistance