title: Evaluation of the open and laparoscopic appendectomy operations with respect to their effect on serum IL-6 levels.
abstract: BACKGROUND
  Postoperative serum inflammatory cytokine levels are thought to reflect the magnitude of surgical stress. Cytokine interleukin-6 (IL-6) is an early marker of systemic inflammatory response and tissue damage. This study evaluated levels of IL-6 after open and laparoscopic appendectomy to compare the degree of surgical stress associated with these procedures.
  
  
  METHODS
  IL-6 levels were measured pre- and postoperatively in the plasma of 200 consecutive patients with a diagnosis of acute appendicitis. After preoperative randomization, 100 patients underwent open appendectomy, and 100 patients underwent laparoscopic appendectomy.
  
  
  RESULTS
  Preoperative concentrations of IL-6 were 65.22±4.76 pg/mL in the open appendectomy group and 65.73±6.34 pg/mL in the laparoscopic appendectomy group (p=0.752). Postoperative levels were 105.28±16.14 pg/mL and 76.11±16.18 pg/mL, respectively (p<0.05).
  
  
  CONCLUSIONS
  Lower postoperative serum IL-6 levels suggest that laparoscopic surgery is associated with lower degree of surgical stress. Laparoscopic appendectomy has significant advantage over open appendectomy due to more rapid postoperative recovery.
authors.affiliation: Department of General Surgery, Van Training and Research Hospital, Van-Turkey.
authors.forename: Mehmet Kadir
authors.initials: MK
authors.lastname: Bartın
authors.affiliation: Department of General Surgery, Yüzüncü Yıl University Faculty of Medicine, Van-Turkey.
authors.forename: Özgür
authors.initials: Ö
authors.lastname: Kemik
authors.affiliation: Department of General Surgery, Dışkapı Yıldırım Beyazıd Training and Research Hospital, Ankara-Turkey.
authors.forename: Mehmet Ali
authors.initials: MA
authors.lastname: Çaparlar
authors.affiliation: Department of General Surgery, Dışkapı Yıldırım Beyazıd Training and Research Hospital, Ankara-Turkey. mtanerbostanci@gmail.com.
authors.forename: Mustafa Taner
authors.initials: MT
authors.lastname: Bostancı
authors.affiliation: Department of General Surgery, Van Training and Research Hospital, Van-Turkey.
authors.forename: Muzaffer Önder
authors.initials: MÖ
authors.lastname: Öner
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D001062:Appendectomy; D001064:Appendicitis / Q000097:blood / Q000601:surgery*; D015415:Biomarkers / Q000097:blood*; D016207:Cytokines / Q000097:blood; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D010535:Laparoscopy; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D014421:Turkey; D055815:Young Adult
chemical_list: D015415:Biomarkers; D016207:Cytokines; D015850:Interleukin-6