title: Review of seasonal influenza in Canada: Burden of disease and the cost-effectiveness of quadrivalent inactivated influenza vaccines.
abstract: In the 2015/16 influenza season, the Canadian National Advisory Committee on Immunization (NACI) recommended vaccination with quadrivalent inactivated influenza vaccine (QIV) for infants aged 6-23 months and trivalent inactivated influenza vaccines (TIVs) or QIVs in adults. The objective of this review (GSK study identifier: HO-13-14054) is to examine the epidemiology and disease burden of influenza in Canada and the economic benefits of vaccination. To inform this review, we performed a systematic literature search of relevant Canadian literature and National surveillance data. Influenza B viruses from phylogenetically-distinct lineages (B/Yamagata and B/Victoria) co-circulate in Canada, and are an important cause of influenza complications. Modeling studies, including those postdating the search suggest that switching from TIV to QIV in Canada reduces the burden of influenza and would likely be cost-effective. However, more robust real-world outcomes data is required to inform health policy decision makers on appropriate influenza vaccination strategies for Canada.
authors.affiliation: a GSK, Health Economics and Outcomes Research , Mississauga , Ontario , Canada.|b Department of Mathematics and Statistics , University of Guelph , Guelph , Ontario , Canada.
authors.forename: Edward W
authors.initials: EW
authors.lastname: Thommes
authors.affiliation: c Optum, Health Economics and Outcomes Research , San Jose , CA , USA.
authors.forename: Morgan
authors.initials: M
authors.lastname: Kruse
authors.affiliation: d Optum, Health Economics and Outcomes Research , Burlington , Ontario , Canada.
authors.forename: Michele
authors.initials: M
authors.lastname: Kohli
authors.affiliation: e GSK, Medical Affairs , Mississauga , Ontario , Canada.
authors.forename: Rohita
authors.initials: R
authors.lastname: Sharma
authors.affiliation: f GSK, Health Economics and Outcomes Research , Mississauga , Ontario , Canada.
authors.forename: Stephen G
authors.initials: SG
authors.lastname: Noorduyn
mesh_terms: D002170:Canada / Q000453:epidemiology; D017281:Cost of Illness; D003362:Cost-Benefit Analysis; D006801:Humans; D007252:Influenza Vaccines / Q000008:administration & dosage / Q000191:economics* / Q000276:immunology*; D007251:Influenza, Human / Q000191:economics / Q000453:epidemiology* / Q000517:prevention & control*; D015233:Models, Statistical; D014611:Vaccination / Q000191:economics*; D015164:Vaccines, Inactivated / Q000008:administration & dosage / Q000191:economics / Q000276:immunology; D014739:Victoria
chemical_list: D007252:Influenza Vaccines; D015164:Vaccines, Inactivated
keywords: burden; costs; epidemiology; hospitalization; influenza; influenza vaccine; lineage-mismatch; quadrivalent