title: Single CT for attenuation correction of rest/stress cardiac SPECT perfusion imaging.
abstract: Common practice is to use separate CT scans acquired during rest and stress for attenuation correction of SPECT myocardial perfusion imaging (MPI). We evaluated using a single CT scan to correct both rest and stress SPECT scans. Studies from 154 patients were reprocessed using one CT acquired at stress to correct both rest and stress scans (1CT) and compared to correction of each scan with its own CT (2CT). Two expert readers independently read the images and determined summed stress (SSS), rest (SRS), and difference (SDS) scores. The correlation in SRS between 2CT and 1CT was r ≥ 0.88. The concordance in SDS was ≥0.84 (kappa ≥ 0.62). The mean SDS difference between 2CT and 1CT for the averaged observer was not significantly different from zero (p > 0.31). 1CT images had a small but significant increase in SRS and an increase in SDS variability. However, the mean SDS difference was similar to the mean inter-observer SDS difference for the 2CT approach (-0.08 vs -0.23, p = 0.46) and had less uncertainty (1.02 vs 2.05, p < 0.001). Thus, the differences between 1CT and 2CT are unlikely to be clinically significant, and the 1CT approach is feasible for SPECT MPI.
authors.affiliation: Division of Cardiology, University of Ottawa Heart Institute, Ottawa, ON, Canada. gwells@ottawaheart.ca.
authors.forename: R Glenn
authors.initials: RG
authors.lastname: Wells
authors.affiliation: Division of Cardiology, University of Ottawa Heart Institute, Ottawa, ON, Canada.
authors.forename: Mikael
authors.initials: M
authors.lastname: Trottier
authors.affiliation: Frankston Hospital, Frankston, Australia.|Monash University, Clayton, VIC, Australia.
authors.forename: Manuja
authors.initials: M
authors.lastname: Premaratne
authors.affiliation: Division of Cardiology, University of Ottawa Heart Institute, Ottawa, ON, Canada.
authors.forename: Karen
authors.initials: K
authors.lastname: Vanderwerf
authors.affiliation: Division of Cardiology, University of Ottawa Heart Institute, Ottawa, ON, Canada.|Division of Nuclear Medicine, Ottawa Hospital, Ottawa, ON, Canada.
authors.forename: Terrence D
authors.initials: TD
authors.lastname: Ruddy
mesh_terms: D000368:Aged; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging; D005080:Exercise Test; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging; D017202:Myocardial Ischemia; D055414:Myocardial Perfusion Imaging; D015588:Observer Variation; D019275:Radiopharmaceuticals; D012189:Retrospective Studies; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed
chemical_list: D019275:Radiopharmaceuticals
keywords: SPECT; attenuation correction; myocardial perfusion imaging; radiation dose