title: The Evolution of Thyroid Function after Presenting with Hashimoto Thyroiditis Is Different between Initially Euthyroid Girls with and Those without Turner Syndrome.
abstract: OBJECTIVE
  To prospectively investigate, during a 5-year follow-up, whether the prognosis of thyroid function with Hashimoto thyroiditis (HT) is different in euthyroid girls with Turner syndrome (TS) than in euthyroid girls without TS.
  
  
  METHODS
  In 66 TS girls and 132 non-TS girls with euthyroid HT and similar thyroid functional test results at HT diagnosis, we followed up the evolution of thyroid status over time.
  
  
  RESULTS
  At the end of follow-up, the TS girls exhibited higher TSH levels, lower fT4 levels, and lower prevalence rates of both euthyroidism and subclinical hypothyroidism, but higher prevalence rates of both overt hypothyroidism and hyperthyroidism, irrespective of the karyotype.
  
  
  CONCLUSIONS
  An association with TS is able to impair the long-term prognosis of thyroid function in girls with HT. Such an effect occurs irrespective of thyroid functional test results at HT diagnosis and is not necessarily linked with a specific karyotype.
authors.affiliation: Department of Adult and Developmental Human Pathology "Gaetano Barresi," University of Messina, Messina, Italy.
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Wasniewska
authors.forename: Mariacarolina
authors.initials: M
authors.lastname: Salerno
authors.forename: Andrea
authors.initials: A
authors.lastname: Corrias
authors.forename: Laura
authors.initials: L
authors.lastname: Mazzanti
authors.forename: Patrizia
authors.initials: P
authors.lastname: Matarazzo
authors.forename: Domenico
authors.initials: D
authors.lastname: Corica
authors.forename: Tommaso
authors.initials: T
authors.lastname: Aversa
authors.forename: Maria Francesca
authors.initials: MF
authors.lastname: Messina
authors.forename: Filippo
authors.initials: F
authors.lastname: De Luca
authors.forename: Mariella
authors.initials: M
authors.lastname: Valenzise
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006044:Goiter, Nodular / Q000097:blood*; D050031:Hashimoto Disease / Q000097:blood*; D006801:Humans; D011446:Prospective Studies; D013961:Thyroid Gland / Q000378:metabolism*; D013972:Thyrotropin / Q000097:blood*; D013974:Thyroxine / Q000097:blood*; D014424:Turner Syndrome / Q000097:blood*
chemical_list: D013972:Thyrotropin; D013974:Thyroxine