title: Electrospun mupirocin loaded polyurethane fiber mats for anti-infection burn wound dressing application.
abstract: Wound care treatment is a serious issue faced by the medical staffs due to its variety and complexity. Wound dressings are typically used to manage the various types of wounds. In this study, polyurethane (PU) fibers containing mupirocin (Mu), a commonly used antibiotic in wound care, were fabricated via electrospinning technique. The aim of this study was to develop biomedical electrospun fiber scaffolds for preventing wound infections with good compatibility and to demonstrate their applications as anti-infective burn wound dressings. The surface morphology of fibers was obtained by scanning electron microscopy. FT-IR spectra, water vapor transmission rate, and drug release study in vitro were tested to demonstrate the fiber scaffold characteristic. The prepared PU/Mu composite scaffolds had satisfactory antibacterial activity especially against Staphylococcus aureus. The cell studies revealed that the scaffolds were biocompatible and safe for cell attachment. Histological and immunohistochemical examinations were performed in rats, and the results indicated the histological analysis of tissue stained with H&E showed no obvious inflammation reaction. The results indicated that the electrospun scaffolds were capable of loading and delivering drugs, and could be potentially used as novel antibacterial burn wound dressings.
authors.affiliation: a Department of Burns and Plastic Surgery , The First Hospital of Jilin University , Changchun , PR China.
authors.forename: Xinxin
authors.initials: X
authors.lastname: Chen
authors.affiliation: b Alan G. MacDiarmid Institute , Jilin University , Changchun , PR China.
authors.forename: Rui
authors.initials: R
authors.lastname: Zhao
authors.affiliation: a Department of Burns and Plastic Surgery , The First Hospital of Jilin University , Changchun , PR China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Wang
authors.affiliation: b Alan G. MacDiarmid Institute , Jilin University , Changchun , PR China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Li
authors.affiliation: a Department of Burns and Plastic Surgery , The First Hospital of Jilin University , Changchun , PR China.
authors.forename: Fei
authors.initials: F
authors.lastname: Peng
authors.affiliation: a Department of Burns and Plastic Surgery , The First Hospital of Jilin University , Changchun , PR China.
authors.forename: Zhenghua
authors.initials: Z
authors.lastname: Jin
authors.affiliation: a Department of Burns and Plastic Surgery , The First Hospital of Jilin University , Changchun , PR China.
authors.forename: Xinxin
authors.initials: X
authors.lastname: Gao
authors.affiliation: a Department of Burns and Plastic Surgery , The First Hospital of Jilin University , Changchun , PR China.
authors.forename: Jiaao
authors.initials: J
authors.lastname: Yu
authors.affiliation: b Alan G. MacDiarmid Institute , Jilin University , Changchun , PR China.
authors.forename: Ce
authors.initials: C
authors.lastname: Wang
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D001458:Bandages / Q000382:microbiology*; D002056:Burns / Q000628:therapy*; D002460:Cell Line; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D004560:Electricity; D016712:Mupirocin / Q000737:chemistry* / Q000494:pharmacology*; D011140:Polyurethanes / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D004337:Drug Carriers; D011140:Polyurethanes; D016712:Mupirocin
keywords: Electrospinning; anti-infection; burn wound dressing; mupirocin