title: The expression of Smad signaling pathway in myocardium and potential therapeutic effects.
abstract: Myocardial infarction (MI) is a life-threatening disease. The expression of Smad proteins in the ischemic myocardium changes significantly following myocardial infarction, suggesting a close relationship between Smad proteins and heart remodeling. Moreover, it is known that the expression of Smads is regulated by transforming growth factor-β (TGF-β) and bone morphogenetic proteins (BMP). Based on these findings, regulating the expression of Smad proteins by targeting TGF-β and BMP in the ischemic myocardium may be considered to be a possible therapeutic strategy for the treatment of myocardial infarction.
authors.affiliation: School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, P.R. China.|Department of Pathology and Laboratory Medicine, University of Cincinnati Medical Center, Cincinnati, OH, USA.
authors.forename: Yuping
authors.initials: Y
authors.lastname: Duan
authors.affiliation: School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, P.R. China. zhuwei@ujs.edu.cn.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhu
authors.affiliation: Department of Pathology and Laboratory Medicine, University of Cincinnati Medical Center, Cincinnati, OH, USA.
authors.forename: Min
authors.initials: M
authors.lastname: Liu
authors.affiliation: Department of Pathology and Laboratory Medicine, University of Cincinnati Medical Center, Cincinnati, OH, USA.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Ashraf
authors.affiliation: Department of Pathology and Laboratory Medicine, University of Cincinnati Medical Center, Cincinnati, OH, USA. meifeng.xu@uc.edu.
authors.forename: Meifeng
authors.initials: M
authors.lastname: Xu
mesh_terms: D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000378:metabolism; D006321:Heart / Q000503:physiopathology*; D006801:Humans; D009203:Myocardial Infarction / Q000235:genetics / Q000503:physiopathology*; D009206:Myocardium / Q000378:metabolism*; D015398:Signal Transduction / Q000235:genetics*; D051785:Smad Proteins / Q000235:genetics*; D016212:Transforming Growth Factor beta / Q000502:physiology
chemical_list: D019485:Bone Morphogenetic Proteins; D051785:Smad Proteins; D016212:Transforming Growth Factor beta