title: [Correlation of Treg and IL-15 expression in the peripheral blood of patients with oral lichen planus].
abstract: OBJECTIVE
  To investigate the expression of Treg and IL-15 in the peripheral blood of patients with oral lichen planus (OLP).
  
  
  METHODS
  The peripheral blood was obtained from 36 OLP patients and 20 healthy controls. Flow cytometry was used to evaluate the proportion of Treg cells, and the level of IL-15 was measured by ELISA. The data were analyzed by SPSS 16.0 software package.
  
  
  RESULTS
  In the peripheral blood of OLP patients, the proportion of CD4+CD25+Foxp3+Treg cells and IL-15 content were significantly higher than those of the healthy controls (P<0.05), but there were no significantly difference between two clinical subtypes of OLP(P>0.05). The proportion of CD4+CD25+Foxp3+Treg cells was positively correlated with the level of IL-15(r=0.70,P<0.05).
  
  
  CONCLUSIONS
  The high expression of Treg cells and IL-15 in the perpheral blood of OLP patients may be responsible for the pathogenesis of OLP.
authors.affiliation: Department of Oral Medicine, Affiliated Hospital of Binzhou Medical University. Binzhou 256603, China. E-mail:wangcuijie126@126.com.
authors.forename: Cui-Jie
authors.initials: CJ
authors.lastname: Wang
authors.forename: Yan-Jun
authors.initials: YJ
authors.lastname: Li
authors.forename: Jiang-Nan
authors.initials: JN
authors.lastname: Xue
authors.forename: Hao-Su
authors.initials: HS
authors.lastname: Ci
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Li
authors.forename: Ling
authors.initials: L
authors.lastname: Li
mesh_terms: D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005434:Flow Cytometry; D006801:Humans; D019409:Interleukin-15; D017676:Lichen Planus, Oral; D015398:Signal Transduction; D050378:T-Lymphocytes, Regulatory
chemical_list: D019409:Interleukin-15