title: The Utility of the Systemic Inflammatory Respsonse Syndrome Score on Admission in Children With Acute Pancreatitis.
abstract: Pediatric patients with acute pancreatitis (AP) may meet criteria at admission for the systemic inflammatory response syndrome (SIRS). Early SIRS in adults with AP is associated with severe disease. Our aim was to evaluate the importance of SIRS in children presenting with AP on various outcomes.
  
  
  
  This is a retrospective cohort study of children hospitalized with AP at Boston Children's Hospital in 2010. Increased length of stay (LOS) and/or admission to the intensive care unit (ICU) served as the primary outcomes. Statistical analyses of measures studied included the presence of SIRS, demographic, and clinical information present on admission.
  
  
  
  Fifty encounters, in which AP was the primary admitting diagnosis, were documented. Patients had a median LOS of 4.5 (interquartile range, 2-9) days. Systemic inflammatory response syndrome was present in 22 (44%) of 50 patients at admission. Systemic inflammatory response syndrome at admission was an independent predictor of increased LOS (odds ratio, 7.99; P = 0.045) as well as admission to the ICU (odds ratio, 12.06; P = 0.027).
  
  
  
  The presence of SIRS criteria on admission serves as a useful and easy-to-calculate predictor of increased LOS and admission to ICU in children with AP.
authors.affiliation: From the *Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA; †Division of Gastroenterology, Center for Pancreatic Disease, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; ‡Division of Gastroenterology, Hepatology and Nutrition, Ohio State University, Columbus, OH; and §Department of Gastroenterology, Hepatology and Nutrition, University of Massachusetts Memorial Children's Medical Center, Boston, MA.
authors.forename: Amit S
authors.initials: AS
authors.lastname: Grover
authors.forename: Vivek
authors.initials: V
authors.lastname: Kadiyala
authors.forename: Peter A
authors.initials: PA
authors.lastname: Banks
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Grand
authors.forename: Darwin L
authors.initials: DL
authors.lastname: Conwell
authors.forename: Jenifer R
authors.initials: JR
authors.lastname: Lightdale
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006760:Hospitalization / Q000706:statistics & numerical data*; D006801:Humans; D007902:Length of Stay / Q000706:statistics & numerical data; D016015:Logistic Models; D008297:Male; D015999:Multivariate Analysis; D010195:Pancreatitis / Q000150:complications; D010343:Patient Admission / Q000706:statistics & numerical data*; D012189:Retrospective Studies; D018746:Systemic Inflammatory Response Syndrome / Q000150:complications / Q000175:diagnosis*