title: When the Wedding March becomes sad: Semantic memory impairment for music in the semantic variant of primary progressive aphasia.
abstract: Music can induce particular emotions and activate semantic knowledge. In the semantic variant of primary progressive aphasia (svPPA), semantic memory is impaired as a result of anterior temporal lobe (ATL) atrophy. Semantics is responsible for the encoding and retrieval of factual knowledge about music, including associative and emotional attributes. In the present study, we report the performance of two individuals with svPPA in three experiments. NG with bilateral ATL atrophy and ND with atrophy largely restricted to the left ATL. Experiment 1 assessed the recognition of musical excerpts and both patients were unimpaired. Experiment 2 studied the emotions conveyed by music and only NG showed impaired performance. Experiment 3 tested the association of semantic concepts to musical excerpts and both patients were impaired. These results suggest that the right ATL seems essential for the recognition of emotions conveyed by music and that the left ATL is involved in binding music to semantics. They are in line with the notion that the ATLs are devoted to the binding of different modality-specific properties and suggest that they are also differentially involved in the processing of factual and emotional knowledge associated with music.
authors.affiliation: a Faculté de médecine, Département de réadaptation , Université Laval , Québec , Canada.|b Centre de recherche de l'Institut universitaire en santé mentale de Québec , Québec , Canada.
authors.forename: Joël
authors.initials: J
authors.lastname: Macoir
authors.affiliation: a Faculté de médecine, Département de réadaptation , Université Laval , Québec , Canada.
authors.forename: Sarah
authors.initials: S
authors.lastname: Berubé-Lalancette
authors.affiliation: a Faculté de médecine, Département de réadaptation , Université Laval , Québec , Canada.|b Centre de recherche de l'Institut universitaire en santé mentale de Québec , Québec , Canada.
authors.forename: Maximiliano A
authors.initials: MA
authors.lastname: Wilson
authors.affiliation: c Clinique Interdisciplinaire de Mémoire , CHU de Québec - Hôpital de l'Enfant-Jésus , Québec , Canada.|d Département de médecine , Faculté de médecine , Québec , Canada.
authors.forename: Robert
authors.initials: R
authors.lastname: Laforce
authors.affiliation: b Centre de recherche de l'Institut universitaire en santé mentale de Québec , Québec , Canada.|e Faculté des Sciences sociales, École de psychologie , Université Laval , Québec , Canada.
authors.forename: Carol
authors.initials: C
authors.lastname: Hudon
authors.affiliation: b Centre de recherche de l'Institut universitaire en santé mentale de Québec , Québec , Canada.
authors.forename: Pierre
authors.initials: P
authors.lastname: Gravel
authors.affiliation: b Centre de recherche de l'Institut universitaire en santé mentale de Québec , Québec , Canada.
authors.forename: Olivier
authors.initials: O
authors.lastname: Potvin
authors.affiliation: b Centre de recherche de l'Institut universitaire en santé mentale de Québec , Québec , Canada.|f Faculté de médecine, Département de radiologie , Université Laval , Québec , Canada.
authors.forename: Simon
authors.initials: S
authors.lastname: Duchesne
authors.affiliation: a Faculté de médecine, Département de réadaptation , Université Laval , Québec , Canada.|b Centre de recherche de l'Institut universitaire en santé mentale de Québec , Québec , Canada.
authors.forename: Laura
authors.initials: L
authors.lastname: Monetta
mesh_terms: D000161:Acoustic Stimulation; D000368:Aged; D018888:Aphasia, Primary Progressive / Q000150:complications* / Q000000981:diagnostic imaging; D001284:Atrophy / Q000209:etiology / Q000473:pathology; D004644:Emotions / Q000502:physiology*; D005260:Female; D006801:Humans; D007600:Judgment / Q000502:physiology; D007807:Language Tests; D008279:Magnetic Resonance Imaging; D008297:Male; D008569:Memory Disorders / Q000209:etiology*; D008609:Mental Status Schedule; D008875:Middle Aged; D009146:Music; D009483:Neuropsychological Tests; D021641:Recognition, Psychology; D012660:Semantics; D013702:Temporal Lobe / Q000473:pathology
keywords: Cognition; models; semantic memory; semantic variant of primary progressive aphasia; temporal lobe