title: NEOPLASM study: Real-life use of lacosamide in patients with brain tumor-related epilepsy.
abstract: The choice of antiepileptic drug (AED) therapy in patients with brain tumor-related epilepsy (BTRE) is complicated, and there are a lack of robust clinical trial data to date.
  
  
  
  The NEOPLASM (Neuroncologic Patients treated with LAcoSaMide) study was a 6-month, multicenter, retrospective, observational study in patients with BTRE treated with lacosamide. Patients were started on lacosamide because of a lack of efficacy or adverse events (AEs) with prior AEDs or suitability versus other AEDs, according to clinical practice. The primary efficacy variable was the seizure-free rate at 6months. Safety variables included the proportion of patients with an AE and the proportion with an AE that led to discontinuation.
  
  
  
  Overall, 105 patients from 14 hospital centers were included in the analysis. Treatment with lacosamide for 6months resulted in a 30.8% seizure-free rate, and 66.3% of patients had a ≥50% seizure reduction (responders). In the subset of patients included because of a lack of efficacy with prior AEDs, seizure-free rates were 28.0%, and 66.7% of patients were responders. No statistically significant differences in efficacy were observed according to the mechanism of action or enzyme-inducing properties of concomitant AEDs. Adverse events were reported by 41.9% of patients at 6months, and 4.7% of them led to discontinuation. The most common AEs were somnolence/fatigue and dizziness. Notably, 57.1% of the patients who were switched to lacosamide because of AEs with their previous therapy did not report any AE at 6-month follow-up.
  
  
  
  In this open-label, observational study, lacosamide appeared to be effective and well tolerated in a large population of patients with BTRE. Lacosamide may therefore be a promising option for the treatment of patients with BTRE.
authors.affiliation: Hospital Universitario y Politécnico La Fe, Bulevard Sur, s/n, Carretera de Malilla, 46026 Valencia, Spain. Electronic address: vevillanuevah@yahoo.es.
authors.forename: Vicente
authors.initials: V
authors.lastname: Villanueva
authors.affiliation: Hospital Universitario 12 de Octubre, Avda de Córdoba, s/n, 28041 Madrid, Spain.
authors.forename: Rosana
authors.initials: R
authors.lastname: Saiz-Diaz
authors.affiliation: Hospital Universitario Vall d'Hebron, Passeig de la Vall d'Hebron, 119-129, 08035 Barcelona, Spain.
authors.forename: Manuel
authors.initials: M
authors.lastname: Toledo
authors.affiliation: Hospital Clínico Universitario Valencia, Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: Piera
authors.affiliation: Hospital Clínico Universitario Lozano Blesa, Calle de San Juan Bosco, 15, 50009 Zaragoza, Spain.
authors.forename: Jose Angel
authors.initials: JA
authors.lastname: Mauri
authors.affiliation: Instituto de Especialidades Neurológicas, Hospital Quirón, Av Manuel Siurot, 57, 41013 Sevilla, Spain.
authors.forename: Juan Jesús
authors.initials: JJ
authors.lastname: Rodriguez-Uranga
authors.affiliation: Hospital Clínico Universitario Santiago, Spain.
authors.forename: Francisco Javier
authors.initials: FJ
authors.lastname: López-González
authors.affiliation: Hospital Universitario y Politécnico La Fe, Bulevard Sur, s/n, Carretera de Malilla, 46026 Valencia, Spain.
authors.forename: Asier
authors.initials: A
authors.lastname: Gómez-Ibáñez
authors.affiliation: Hospital Universitario y Politécnico La Fe, Bulevard Sur, s/n, Carretera de Malilla, 46026 Valencia, Spain.
authors.forename: Mercedes
authors.initials: M
authors.lastname: Garcés
authors.affiliation: Hospital Universitario 12 de Octubre, Avda de Córdoba, s/n, 28041 Madrid, Spain.
authors.forename: Jesús
authors.initials: J
authors.lastname: González de la Aleja
authors.affiliation: Hospital Clínico Universitario Santiago, Spain.
authors.forename: Xiana
authors.initials: X
authors.lastname: Rodríguez-Osorio
authors.affiliation: Hospital General Universitario Alicante, Spain.
authors.forename: Susana
authors.initials: S
authors.lastname: Palao-Duarte
authors.affiliation: Consorcio Hospital General Universitario de Valencia, Av Tres Cruces, 2, 46014, Valencia, Spain.
authors.forename: Ascensión
authors.initials: A
authors.lastname: Castillo
authors.affiliation: Hospital Arnau de Vilanova, Calle San Clemente, 12, 46015, Valencia, Spain.
authors.forename: Macarena
authors.initials: M
authors.lastname: Bonet
authors.affiliation: Hospital Universitario Virgen de las Nieves, Avenida de las Fuerzas Armadas, 2, 18014 Granada, Spain.
authors.forename: Jesús
authors.initials: J
authors.lastname: Ruiz-Giménez
authors.affiliation: Hospital Manises Avenidad Generalitat Valenciana, 46940 Manises, Spain.
authors.forename: Juan
authors.initials: J
authors.lastname: Palau
authors.affiliation: Hospital Universitario Guadalajara, Guadalajara, Spain.
authors.forename: Alberto
authors.initials: A
authors.lastname: Arcediano
authors.affiliation: Hospital Universitario La Princesa Madrid, Calle Diego de León, Madrid, Spain.
authors.forename: Maria
authors.initials: M
authors.lastname: Toledo
authors.affiliation: Hospital Universitario La Princesa Madrid, Calle Diego de León, Madrid, Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: Gago
mesh_terms: D000081:Acetamides / Q000627:therapeutic use*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000927:Anticonvulsants / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy*; D004827:Epilepsy / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D000078334:Lacosamide; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012640:Seizures / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000081:Acetamides; D000927:Anticonvulsants; D000078334:Lacosamide
keywords: Antiepileptic drugs; Brain tumor; Epilepsy; Lacosamide