title: Identification of patients at risk for preeclampsia with the use of uterine artery Doppler velocimetry and copeptin.
abstract: OBJECTIVE
  To investigate the relationship between maternal copeptin levels and uterine artery Doppler examination and progress of preeclampsia.
  
  
  METHODS
  A cross-sectional study was designed with women those were screened at 20 + 0 - 24+  6 weeks' gestation between May 2014 and August 2014. The obstetric records of all normotensive women were examined. Uterine artery Doppler velocimetry results and serum copeptin levels were measured. The patients were divided into two groups according to normal (n = 67) and abnormal uterine artery Doppler (n = 21) findings.
  
  
  RESULTS
  Maternal age was significantly lower in group 1 (n = 21, 23.9%) than in group 2 (n= 67, 76.1%) (p < 0.05). We found no differences in maternal characteristics, birth weight, gestational age at delivery and copeptin levels between the two groups. Maternal serum copeptin levels were higher in women who subsequently developed preeclampsia. There was also a significant correlation between copeptin levels and the presence of preeclampsia. (p = 0.002).
  
  
  CONCLUSIONS
  Copeptin levels are significantly higher in patients who develop preeclampsia.
authors.affiliation: a Department of Obstetrics and Gynecology , Erzurum Nenehatun Maternity and Children's Disease Hospital , Erzurum , Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Yeşil
authors.affiliation: b Department of Obstetrics and Gynecology , Bakirkoy Dr Sadi Konuk Training and Research Hospital , Istanbul , Turkey.
authors.forename: Ammar
authors.initials: A
authors.lastname: Kanawati
authors.affiliation: b Department of Obstetrics and Gynecology , Bakirkoy Dr Sadi Konuk Training and Research Hospital , Istanbul , Turkey.
authors.forename: Çağlar
authors.initials: Ç
authors.lastname: Helvacıoğlu
authors.affiliation: b Department of Obstetrics and Gynecology , Bakirkoy Dr Sadi Konuk Training and Research Hospital , Istanbul , Turkey.
authors.forename: Cihan
authors.initials: C
authors.lastname: Kaya
authors.affiliation: b Department of Obstetrics and Gynecology , Bakirkoy Dr Sadi Konuk Training and Research Hospital , Istanbul , Turkey.
authors.forename: Çağseli Göksu
authors.initials: ÇG
authors.lastname: Özgün
authors.affiliation: b Department of Obstetrics and Gynecology , Bakirkoy Dr Sadi Konuk Training and Research Hospital , Istanbul , Turkey.
authors.forename: Hüseyin
authors.initials: H
authors.lastname: Cengiz
mesh_terms: D000293:Adolescent; D000328:Adult; D003430:Cross-Sectional Studies; D005260:Female; D005865:Gestational Age; D006020:Glycopeptides / Q000032:analysis / Q000097:blood*; D006801:Humans; D008423:Maternal Age; D008875:Middle Aged; D011225:Pre-Eclampsia / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D011237:Predictive Value of Tests; D011247:Pregnancy; D011296:Prenatal Diagnosis / Q000379:methods*; D012307:Risk Factors; D018608:Ultrasonography, Doppler; D016216:Ultrasonography, Prenatal; D055988:Uterine Artery / Q000000981:diagnostic imaging*; D055815:Young Adult
chemical_list: D006020:Glycopeptides; C048197:copeptins
keywords: Copeptin; Doppler ultrasonography; preeclampsia; pregnancy; uterine artery