title: Immunogenicity of a Live Attenuated Chimeric Japanese Encephalitis Vaccine as a Booster Dose After Primary Vaccination With Live Attenuated SA14-14-2 Vaccine: A Phase IV Study in Thai Children.
abstract: This single-group study investigated the immunogenicity and safety of a booster dose of the recently licensed live attenuated chimeric Japanese encephalitis vaccine in 50 healthy children (1-5 years old) who were primed with the live attenuated SA14-14-2 vaccine. A strong anamnestic response was induced 28 days postbooster: geometric mean titer, 9144 (95% confidence interval: 7365-11353); and seroprotection rate, 49 of 49 (100%) children.
authors.affiliation: From the *Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand; †Sanofi Pasteur, Bangkok, Thailand; and ‡Clinical Sciences, Sanofi Pasteur, Singapore.
authors.forename: Sirintip
authors.initials: S
authors.lastname: Sricharoenchai
authors.forename: Keswadee
authors.initials: K
authors.lastname: Lapphra
authors.forename: Sunate
authors.initials: S
authors.lastname: Chuenkitmongkol
authors.forename: Wanatpreeya
authors.initials: W
authors.lastname: Phongsamart
authors.forename: Alain
authors.initials: A
authors.lastname: Bouckenooghe
authors.forename: Orasri
authors.initials: O
authors.lastname: Wittawatmongkol
authors.forename: Supattra
authors.initials: S
authors.lastname: Rungmaitree
authors.forename: Kulkanya
authors.initials: K
authors.lastname: Chokephaibulkit
mesh_terms: D057134:Antibodies, Neutralizing / Q000097:blood; D000914:Antibodies, Viral / Q000097:blood*; D002675:Child, Preschool; D018349:Encephalitis Viruses, Japanese / Q000276:immunology*; D004672:Encephalitis, Japanese / Q000517:prevention & control; D006801:Humans; D007117:Immunization, Secondary; D007223:Infant; D022321:Japanese Encephalitis Vaccines / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology*; D013785:Thailand; D014613:Vaccines, Attenuated / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology*
chemical_list: D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral; D022321:Japanese Encephalitis Vaccines; D014613:Vaccines, Attenuated