title: Current trends in clinical genetics of colorectal cancer.
abstract: Recent innovations in molecular biology and colorectal cancer (CRC) genetics have facilitated the understanding of the pathogenesis of sporadic and hereditary CRC syndromes. The development of technology has enabled data collection for a number of genetic factors, which lead to understanding of the molecular mechanisms underlying CRC. The incidence and the nature of CRC is a mixture of genetic and environmental factors. The current field of interest is to understand how molecular basis could shape predisposition for developing CRC, disease progression and response to chemotherapy. In this article, we summarize new and developing genetic markers, and assess their clinical value for inherited and sporadic CRC.
authors.affiliation: Department for Gastroenterology and Hepatology, University City Hospital, Belgrade, Serbia.
authors.forename: Srdjan
authors.initials: S
authors.lastname: Markovic
authors.forename: Ivan
authors.initials: I
authors.lastname: Dimitrijevic
authors.forename: Branimir
authors.initials: B
authors.lastname: Zogovic
authors.forename: Velimir
authors.initials: V
authors.lastname: Markovic
authors.forename: Goran
authors.initials: G
authors.lastname: Barisic
authors.forename: Zoran
authors.initials: Z
authors.lastname: Krivokapic
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000235:genetics*; D015179:Colorectal Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D019008:Drug Resistance, Neoplasm / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing / Q000639:trends; D005826:Genetics, Medical / Q000639:trends*; D006801:Humans; D009386:Neoplastic Syndromes, Hereditary / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D010641:Phenotype; D057285:Precision Medicine / Q000639:trends; D011237:Predictive Value of Tests
chemical_list: D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor