title: [Prostate biopsy results and clinicopathological characteristics of the 55 years or younger patients].
abstract: Objective:To explore the clinical features, biopsy results and risk factors of patients underwent prostate biopsy with age≤55, and to help make the proper treatment strategies of this cohort of patients.Methods:The data of patients with age≤55 underwent prostate biopsy between Jan 2011 and Nov 2013 was retrospectively reviewed. Clinical factors including prostate-specific antigen, digital rectal examination, ultrasonography and magnetic resonance imaging were recorded. Biopsy positive results were defined as the presence of prostate cancer and high-grade prostate cancer (Gleason score≥7).Results:There were all together 82 patients in this cohort, with the median age of 51 years old and median prostate-specific antigen of 8.62 μg/L. Among them 71 patients (86.6%) underwent pre-biopsy magnetic resonance imaging test, with 25 positive (35.2%), 18 suspicious (25.4%) and 28 negative results (39.4%). Pathology confirmed prostate cancer in 26 patients (31.7%), including 23 (28.0%) high-grade prostate cancer. Higher prostate-specific antigen, positive ultrasonography and positive magnetic resonance imaging were risk factors for prostate cancer and high-grade prostate cancer. For patients with prostate-specific antigen between 4 and 10 μg/L, 15.0% were diagnosed with prostate cancer, and positive ultrasound and magnetic resonance imaging were predictive for biopsy results.Conclusions:The positive rate of prostate biopsy in men younger than 55 years old is 31.7%, and the risk for prostate cancer of this cohort of patients shouldn't be neglected. Prostate-specific antigen value, ultrasonography and magnetic resonance imaging could help predict biopsy results.
authors.affiliation: Department of Urology, Peking University First Hospital, Institute of Urology, Peking University, National Urological Cancer Center, Beijing 100034, China.
authors.forename: G
authors.initials: G
authors.lastname: Song
authors.forename: D
authors.initials: D
authors.lastname: Fang
authors.forename: G J
authors.initials: GJ
authors.lastname: Ji
authors.forename: W
authors.initials: W
authors.lastname: Yu
authors.forename: C L
authors.initials: CL
authors.lastname: Zhao
authors.forename: X S
authors.initials: XS
authors.lastname: Li
authors.forename: G Z
authors.initials: GZ
authors.lastname: Shan
authors.forename: S Q
authors.initials: SQ
authors.lastname: Li
authors.forename: Q
authors.initials: Q
authors.lastname: He
authors.forename: Z C
authors.initials: ZC
authors.lastname: Xin
authors.forename: X Y
authors.initials: XY
authors.lastname: Wang
authors.forename: L Q
authors.initials: LQ
authors.lastname: Zhou
mesh_terms: D001706:Biopsy; D051517:Digital Rectal Examination; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D011467:Prostate / Q000473:pathology*; D017430:Prostate-Specific Antigen; D011471:Prostatic Neoplasms; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D017430:Prostate-Specific Antigen