title: The Association between Arrhythmia and Helicobacter pylori Infection: A Meta-Analysis of Case-Control Studies.
abstract: Arrhythmia is a common disease around the world andHelicobacter pylori(H. pylori) is a bacterium infecting 28% to 84% of subjects, depending on the population tested. However, the implication ofH. pyloriin cardiac arrhythmia is poorly understood. We performed this meta-analysis with an aim to identify the association between arrhythmia andH. pylori. We searched PubMed, Embase, Web of Science, and the Cochrane library databases to select studies on the association between arrhythmia andH. pylori. In the arrhythmia group, 392 (58.1%) wereH. pylori-positive and in the control group 640 (47.8%) wereH. pylori-positive. Compared to the controls, the infection rate ofH. pyloriwas higher in patients with arrhythmia than in controls (odds ratio (OR) = 1.797, 95% confidence interval (CI): 1.081-2.988,p< 0.05). Subgroup analysis indicated thatH. pyloriinfection was a risk factor for atrial fibrillation in Asia and Africa. Therefore, a correlation betweenH. pyloriinfection and arrhythmia may exist andH. pylorieradication may decrease the occurrence of arrhythmia, especially in Asia and Africa.
authors.affiliation: Department of Gastroenterology, The First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, China. yanjinnmu@163.com.|The First Clinical Medical College, Nanjing Medical University, Nanjing 210029, China. yanjinnmu@163.com.
authors.forename: Jin
authors.initials: J
authors.lastname: Yan
authors.affiliation: The First Clinical Medical College, Nanjing Medical University, Nanjing 210029, China. sheqiangyanjin@sina.com.|Department of Gastroenterology, Yangzhou NO.1 People's Hospital, Yangzhou 225001, China. sheqiangyanjin@sina.com.
authors.forename: Qiang
authors.initials: Q
authors.lastname: She
authors.affiliation: Department of Gastroenterology, The First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, China. zhangyifengyj@sina.com.|The First Clinical Medical College, Nanjing Medical University, Nanjing 210029, China. zhangyifengyj@sina.com.
authors.forename: Yifeng
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: The First Clinical Medical College, Nanjing Medical University, Nanjing 210029, China. cuichangyanjin@sina.com.|Department of Cardiology, The First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, China. cuichangyanjin@sina.com.
authors.forename: Chang
authors.initials: C
authors.lastname: Cui
authors.affiliation: Department of Gastroenterology, The First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, China. guoxinz@njmu.edu.cn.|The First Clinical Medical College, Nanjing Medical University, Nanjing 210029, China. guoxinz@njmu.edu.cn.
authors.forename: Guoxin
authors.initials: G
authors.lastname: Zhang
mesh_terms: D000349:Africa; D001145:Arrhythmias, Cardiac / Q000209:etiology* / Q000382:microbiology*; D001208:Asia; D016022:Case-Control Studies; D016481:Helicobacter Infections / Q000150:complications*; D016480:Helicobacter pylori / Q000472:pathogenicity*; D006801:Humans; D016017:Odds Ratio; D012307:Risk Factors
keywords: Helicobacter pylori; arrhythmia; meta-analysis