title: Implementation of a Simplified Regional Citrate Anticoagulation Protocol for Post-Dilution Continuous Hemofiltration Using a Bicarbonate Buffered, Calcium Containing Replacement Solution.
abstract: Recent updates to the Nikkiso Aquarius continuous renal replacement therapy (CRRT) platform allowed us to develop a post-dilution protocol for regional citrate anticoagulation (RCA) using standard bicarbonate buffered, calcium containing replacement solution with acid citrate dextrose formula-A as a citrate source. Our objective was to demonstrate that the protocol was safe and effective.
  
  
  
  Prospective audit of consecutive patients receiving RCA for CRRT within intensive care unit, who were either contraindicated to heparin or had poor filter lifespan (<12 h for 2 consecutive filters) on heparin.
  
  
  
  We present the first 29 patients who used 98 filters. After excluding 'non-clot' filter loss, 50% had a duration of >27 h. Calcium supplementation was required for 30 (30%) filter circuits, in 17 of 29 (58%) patients. One patient discontinued the treatment due to metabolic alkalosis, but there were no adverse bleeding events.
  
  
  
  Post-dilution RCA system is effective and simple to use on the Aquarius platform and results in comparable filter life for patients relatively contraindicated to heparin.
authors.affiliation: Critical Care and Perioperative Medicine Research Group, William Harvey Research Institute, Queen Mary University of London, London, UK.
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Kirwan
authors.forename: Ross
authors.initials: R
authors.lastname: Hutchison
authors.forename: Sherif
authors.initials: S
authors.lastname: Ghabina
authors.forename: Stephanie
authors.initials: S
authors.lastname: Schwarze
authors.forename: Abigail
authors.initials: A
authors.lastname: Beane
authors.forename: Susan
authors.initials: S
authors.lastname: Ramsay
authors.forename: Edward
authors.initials: E
authors.lastname: Thompson
authors.forename: John R
authors.initials: JR
authors.lastname: Prowle
mesh_terms: D000925:Anticoagulants / Q000008:administration & dosage*; D001639:Bicarbonates / Q000737:chemistry; D002021:Buffers; D019343:Citric Acid / Q000008:administration & dosage*; D015314:Dialysis Solutions / Q000008:administration & dosage / Q000737:chemistry; D004573:Electrolytes / Q000737:chemistry; D005260:Female; D006440:Hemofiltration / Q000379:methods; D006801:Humans; D008297:Male; D016896:Treatment Outcome
chemical_list: D000925:Anticoagulants; D001639:Bicarbonates; D002021:Buffers; D015314:Dialysis Solutions; D004573:Electrolytes; D019343:Citric Acid