title: One Pot Single Step Synthesis and Biological Evaluation of Some Novel Bis(1,3,4-thiadiazole) Derivatives as Potential Cytotoxic Agents.
abstract: A novel series ofbis(1,3,4-thiadiazole) derivatives were synthesized in one step methodology with good yields by condensation reaction betweenbis-hydrazonoyl chloride1and various reagents. The structures of the prepared compounds were confirmed by spectral data (IR, NMR, and MS), and elemental analysis. The anticancer activity against human breast carcinoma (MCF-7) cancer cell lines was evaluated in MTT assay. The results revealed that thebis-thiadiazole derivatives5c,d,7b,cand9chad higher antitumor activity than the standard drug Imatinib.
authors.affiliation: Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt. s.m.gomha@gmail.com.
authors.forename: Sobhi M
authors.initials: SM
authors.lastname: Gomha
authors.affiliation: Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt. nabila.abdelshafy@gmail.com.|Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Khalid University, Abha 61441, Saudi Arabia. nabila.abdelshafy@gmail.com.
authors.forename: Nabila A
authors.initials: NA
authors.lastname: Kheder
authors.affiliation: Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt. abdelhamid45@gmail.com.
authors.forename: Abdou O
authors.initials: AO
authors.lastname: Abdelhamid
authors.affiliation: Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia. yahia@ksu.edu.sa.
authors.forename: Yahia N
authors.initials: YN
authors.lastname: Mabkhot
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D060326:Chemistry Techniques, Synthetic; D003603:Cytotoxins / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D013830:Thiadiazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D003603:Cytotoxins; D013830:Thiadiazoles; C058949:1,3,4-thiadiazole
keywords: anticancer activity; bis(1,3,4-thiadiazole); bis-hydrazonoyl chlorides; dipolar cycloaddition reaction; methyl arylidene dithiocarbamate