title: Circulating CLA+T cells in atopic dermatitis and their possible role as peripheral biomarkers.
abstract: Cutaneous lymphocyte-associated antigen (CLA+) T cells are specialized for skin homing and represent the main T-cell population in atopic dermatitis (AD) lesions. CLA+is expressed on the surface of circulating CD45RO+memory T cells and most skin-infiltrating T cells. Mechanistic studies and thus treatment advancements are limited by the need of large number of skin biopsies. Circulating CLA+T cells may be a reliable surrogate marker of the inflammatory events occurring in the skin, and thus, the evaluation of CLA+T cells in the blood may eliminate the need for skin biopsies. Preliminary work in AD has established that disease-associated T-cell abnormalities can be approached by either a study of skin lesions or activated CLA+T-cell subsets in peripheral blood. Future studies in adults and children, across different skin disorders, correlating blood and skin phenotypes and determining skin-homing T-cell functional properties are needed to establish whether CLA+memory subsets can be used as biomarkers and a substitute for skin biopsies. This review summarizes the latest advancements reached on circulating CLA+in AD and the great potential they harbor in understanding AD mechanisms.
authors.affiliation: Department of Dermatology and the Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.|Laboratory for Investigative Dermatology, The Rockefeller University, New York, NY, USA.
authors.forename: T
authors.initials: T
authors.lastname: Czarnowicki
authors.affiliation: Translational Immunology, Department of Cellular Biology, Physiology, and Immunology, Universitat de Barcelona, Barcelona, Spain.
authors.forename: L F
authors.initials: LF
authors.lastname: Santamaria-Babí
authors.affiliation: Department of Dermatology and the Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.|Laboratory for Investigative Dermatology, The Rockefeller University, New York, NY, USA.
authors.forename: E
authors.initials: E
authors.lastname: Guttman-Yassky
mesh_terms: D000367:Age Factors; D000945:Antigens, Differentiation, T-Lymphocyte / Q000378:metabolism*; D015415:Biomarkers; D003876:Dermatitis, Atopic / Q000097:blood / Q000276:immunology* / Q000378:metabolism*; D006801:Humans; D016130:Immunophenotyping; D018655:Lymphocyte Count; D016169:Lymphocyte Function-Associated Antigen-1 / Q000378:metabolism; D008562:Membrane Glycoproteins / Q000378:metabolism*; D010641:Phenotype; D012867:Skin / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D016176:T-Lymphocyte Subsets / Q000276:immunology* / Q000378:metabolism*
chemical_list: D000945:Antigens, Differentiation, T-Lymphocyte; D015415:Biomarkers; C063419:CTAGE1 protein, human; D016169:Lymphocyte Function-Associated Antigen-1; D008562:Membrane Glycoproteins
keywords: 
  CLA
  ; T cells; atopic dermatitis