title: Thiol/disulfide homeostasis in postmenopausal osteoporosis.
abstract: OBJECTIVE
  To evaluate the impact of postmenopausal osteoporosis on thiol/disulfide homeostasis.
  
  
  METHODS
  A total of 75 participants were divided into two groups: Group 1 (n = 40) was composed of healthy postmenopausal women, and group 2 (n = 35) was composed of women with postmenopausal osteoporosis. Clinical findings and thiol/disulfide homeostasis were compared between the two groups.
  
  
  RESULTS
  The disulfide/native thiol ratio was 8.6% ± 3.6 in group 1 and 12.7% ± 8.4 in group 2 (p = 0.04). The disulfide/native thiol percent ratio was significantly higher in group 2 after adjustment for the years since menopause and age (p < 0.05). The native thiol/total thiol percent ratio was 85.6% ± 4.8 in group 1 and 73.8% ± 24.9 in group 2 (p = 0.01). The native thiol/total thiol percent ratio was significantly lower in group 2 after adjustment for the years since menopause and age (p < 0.05).
  
  
  CONCLUSIONS
  Thiol/disulfide homeostasis shifted to the disulfide side independent of age and years since menopause in postmenopausal osteoporosis.
authors.affiliation: Department of Obstetrics and Gynecology, Ankara Training and Research Hospital, Ankara, Turkey. korkmazvakkas@gmail.com.
authors.forename: V
authors.initials: V
authors.lastname: Korkmaz
authors.affiliation: Department of Obstetrics and Gynecology, Ankara Training and Research Hospital, Ankara, Turkey.
authors.forename: Z
authors.initials: Z
authors.lastname: Kurdoglu
authors.affiliation: Department of Biochemistry, Yıldırım Beyazıt University, Ankara, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Alisik
authors.affiliation: Department of Obstetrics and Gynecology, Ankara Training and Research Hospital, Ankara, Turkey.
authors.forename: E
authors.initials: E
authors.lastname: Turgut
authors.affiliation: Department of Biochemistry, Ankara Training and Research Hospital, Ankara, Turkey.
authors.forename: O O
authors.initials: OO
authors.lastname: Sezgın
authors.affiliation: Department of Physiology, Hacettepe University, Ankara, Turkey.
authors.forename: H
authors.initials: H
authors.lastname: Korkmaz
authors.affiliation: Department of Obstetrics and Gynecology, Ankara Training and Research Hospital, Ankara, Turkey.
authors.forename: Y
authors.initials: Y
authors.lastname: Ergun
authors.affiliation: Department of Biochemistry, Yıldırım Beyazıt University, Ankara, Turkey.
authors.forename: O
authors.initials: O
authors.lastname: Erel
mesh_terms: D016022:Case-Control Studies; D004220:Disulfides / Q000097:blood*; D005260:Female; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000097:blood*; D011379:Prognosis; D013438:Sulfhydryl Compounds / Q000097:blood*
chemical_list: D004220:Disulfides; D013438:Sulfhydryl Compounds
keywords: Disulfide; Postmenopausal osteoporosis; Thiol