title: Crossover comparison of ferumoxytol and gadobenate dimeglumine for abdominal MR-angiography at 3.0 tesla: Effects of contrast bolus length and flip angle.
abstract: Ferumoxytol (FE) has gained interest as an alternative to gadolinium-based contrast agents (GBCAs). The purpose of this study was to evaluate and optimize ferumoxytol dose and T1 weighting, in comparison to a conventional GBCA.
  
  
  
  Twelve healthy volunteers (six women / six men, mean age 44.3 years) were recruited for this study. Scanning was performed on a clinical 3 Tesla (T) MRI system. Gadobenate dimeglumine (GD)-enhanced MRA was performed followed by FE-enhanced MRA 1 month later. Volunteers were randomly assigned to a diluted (n = 6) or undiluted (n = 6) dose of GD (0.1 mmol/kg), and to FE doses of 4 mg/kg (n = 6) or 2 mg/kg (n = 6). First pass and steady-state MRA were performed for GD- and FE-enhanced MRA. Flip-angle optimization was performed after FE administration. Quantitative analysis included relative contrast-to-noise ratio (relCNR) measurements for all acquisitions. First pass GD- and FE-enhanced MRA images were evaluated qualitatively.
  
  
  
  RelCNR was significantly higher with undiluted GD (31.8, 95% confidence interval [CI], 27.7-35.9) compared with diluted GD (16.2; 95% CI, 12.2-20.3; P = 0.001) and both 4 mg/kg FE (12.5; 95% CI, 8.5-16.4; P < 0.001) and 2 mg/kg FE (9.1; 95% CI, 5.1-13.2; P < 0.001) during first pass. Relative CNR did not decrease with FE 5 min postinjection compared with GD. Flip-angle analysis revealed relative CNR-peaks at 30° for FE 4 mg/kg and at 20° for FE 2 mg/kg. Diluted GD (P = 0.013) and FE 4 mg/kg (P = 0.01) revealed significantly higher image quality scores compared with undiluted GD during first pass.
  
  
  
  This study shows an equivalent image quality of FE and GD for first pass MRA even though GD showed significantly higher relative CNR.
  
  
  
  1 Technical Efficacy: Stage 2 J. MAGN. RESON. IMAGING 2017;45:1617-1626.
authors.affiliation: Department of Radiology, University of Wisconsin-Madison, Madison, Wisconsin, USA.|Clinic of Radiology and Nuclear Medicine, Basel University Hospital, Basel, Switzerland.
authors.forename: Tilman
authors.initials: T
authors.lastname: Schubert
authors.affiliation: Department of Radiology, University of Wisconsin-Madison, Madison, Wisconsin, USA.|Department of Radiology, University of Yamanashi, Yamanashi, Japan.
authors.forename: Utaroh
authors.initials: U
authors.lastname: Motosugi
authors.affiliation: Department of Radiology, University of Wisconsin-Madison, Madison, Wisconsin, USA.|Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Germany.
authors.forename: Sonja
authors.initials: S
authors.lastname: Kinner
authors.affiliation: Department of Radiology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Colgan
authors.affiliation: Department of Radiology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
authors.forename: Samir D
authors.initials: SD
authors.lastname: Sharma
authors.affiliation: Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, Wisconsin, USA.
authors.forename: Scott
authors.initials: S
authors.lastname: Hetzel
authors.affiliation: Department of Radiology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
authors.forename: Shane
authors.initials: S
authors.lastname: Wells
authors.affiliation: Department of Radiology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
authors.forename: Camilo A
authors.identifier: 0000-0001-7506-4509
authors.initials: CA
authors.lastname: Campo
authors.affiliation: Department of Radiology, University of Wisconsin-Madison, Madison, Wisconsin, USA.|Department of Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin, USA.|Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.|Department of Emergency Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.|Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, Wisconsin, USA.
authors.forename: Scott B
authors.initials: SB
authors.lastname: Reeder
mesh_terms: D000005:Abdomen / Q000098:blood supply* / Q000000981:diagnostic imaging*; D000328:Adult; D003287:Contrast Media / Q000008:administration & dosage; D018592:Cross-Over Studies; D004305:Dose-Response Relationship, Drug; D005260:Female; D052203:Ferrosoferric Oxide / Q000008:administration & dosage*; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male; D008536:Meglumine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D009942:Organometallic Compounds / Q000008:administration & dosage*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D059629:Signal-To-Noise Ratio
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; C064572:gadobenic acid; D008536:Meglumine; D052203:Ferrosoferric Oxide
keywords: contrast dilution; contrast dose; ferumoxytol; gadobenate dimeglumine