title: Chronic inflammatory demyelinating polyradiculoneuropathy: A new animal model for new therapeutic targets.
abstract: Animal models are fundamental to advance knowledge of disease pathogenesis and to test/develop new therapeutic strategies. Most of the current knowledge about the pathogenic mechanisms underpinning autoimmune demyelination processes implicating autoantigens has been obtained using the Experimental Autoimmune Neuritis (EAN) animal model. The most widely used EAN model is obtained by active immunization of Lewis rats using a peptide, P0 (180-199), issuing from the major peripheral nervous system myelin protein. But this model mimics only the classical monophasic acute form of demyelinating polyradiculoneuropathy, i.e. Guillain-Barré syndrome (GBS). We developed a new model by immunizing Lewis rats using the same immunodominant neuritogenic peptide P0 (180-199) but this time with its S-palmitoyl derivative, S-palm P0 (180-199). All of the animals immunized with the S-palm P0 (180-199) peptide developed a chronic relapsing-remitting form of the disease corresponding to the electrophysiological criteria of demyelination (slow sensory nerve conduction velocity, prolonged motor nerve latency, partial motor nerve conduction blocks) with axon degeneration. These findings were confirmed by immunohistopathology study and thus, appear to mimic human chronic inflammatory demyelinating polyradiculopathy (CIDP). This new model opens up new avenues of research for testing new anti-inflammatory and neuroprotective therapeutic strategies.
authors.affiliation: Biopathologie de la myéline, neuroprotection et stratégies thérapeutiques, UMRS, Inserm U1119, université de Strasbourg, fédération de médecine translationnelle de Strasbourg (FMTS), faculté de médecine, 11, rue Humann, 67000 Strasbourg, France. Electronic address: jerome.de.seze@chru-strasbourg.fr.
authors.forename: J
authors.initials: J
authors.lastname: de Sèze
authors.affiliation: Biopathologie de la myéline, neuroprotection et stratégies thérapeutiques, UMRS, Inserm U1119, université de Strasbourg, fédération de médecine translationnelle de Strasbourg (FMTS), faculté de médecine, 11, rue Humann, 67000 Strasbourg, France.
authors.forename: L
authors.initials: L
authors.lastname: Kremer
authors.affiliation: Biopathologie de la myéline, neuroprotection et stratégies thérapeutiques, UMRS, Inserm U1119, université de Strasbourg, fédération de médecine translationnelle de Strasbourg (FMTS), faculté de médecine, 11, rue Humann, 67000 Strasbourg, France.
authors.forename: C
authors.initials: C
authors.lastname: Alves do Rego
authors.affiliation: Biopathologie de la myéline, neuroprotection et stratégies thérapeutiques, UMRS, Inserm U1119, université de Strasbourg, fédération de médecine translationnelle de Strasbourg (FMTS), faculté de médecine, 11, rue Humann, 67000 Strasbourg, France.
authors.forename: O
authors.initials: O
authors.lastname: Taleb
authors.affiliation: Biopathologie de la myéline, neuroprotection et stratégies thérapeutiques, UMRS, Inserm U1119, université de Strasbourg, fédération de médecine translationnelle de Strasbourg (FMTS), faculté de médecine, 11, rue Humann, 67000 Strasbourg, France.
authors.forename: D
authors.initials: D
authors.lastname: Lam
authors.affiliation: Biopathologie de la myéline, neuroprotection et stratégies thérapeutiques, UMRS, Inserm U1119, université de Strasbourg, fédération de médecine translationnelle de Strasbourg (FMTS), faculté de médecine, 11, rue Humann, 67000 Strasbourg, France.
authors.forename: W
authors.initials: W
authors.lastname: Beiano
authors.affiliation: Biopathologie de la myéline, neuroprotection et stratégies thérapeutiques, UMRS, Inserm U1119, université de Strasbourg, fédération de médecine translationnelle de Strasbourg (FMTS), faculté de médecine, 11, rue Humann, 67000 Strasbourg, France.
authors.forename: G
authors.initials: G
authors.lastname: Mensah-Nyagan
authors.affiliation: Biopathologie de la myéline, neuroprotection et stratégies thérapeutiques, UMRS, Inserm U1119, université de Strasbourg, fédération de médecine translationnelle de Strasbourg (FMTS), faculté de médecine, 11, rue Humann, 67000 Strasbourg, France.
authors.forename: E
authors.initials: E
authors.lastname: Trifilieff
authors.affiliation: Biopathologie de la myéline, neuroprotection et stratégies thérapeutiques, UMRS, Inserm U1119, université de Strasbourg, fédération de médecine translationnelle de Strasbourg (FMTS), faculté de médecine, 11, rue Humann, 67000 Strasbourg, France.
authors.forename: S
authors.initials: S
authors.lastname: Brun
mesh_terms: D000818:Animals; D003711:Demyelinating Diseases / Q000139:chemically induced / Q000188:drug therapy / Q000503:physiopathology; D004195:Disease Models, Animal; D007150:Immunohistochemistry; D009046:Motor Neurons; D009431:Neural Conduction; D009444:Neuritis, Autoimmune, Experimental; D019308:Palmitic Acid / Q000737:chemistry; D020277:Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / Q000139:chemically induced* / Q000188:drug therapy* / Q000503:physiopathology; D051381:Rats; D011917:Rats, Inbred Lew
chemical_list: D019308:Palmitic Acid
keywords: Animal models; Autoimmune; CIDP; Treatment