title: Humoral immunity to tetanus, measles and rubella in children with acute lymphoblastic leukemia after chemotherapy.
abstract: Chemotherapy regimens and clinical support advances have improved survival in children with acute lymphoblastic leukemia. The after-effects of treatment are a reason for concern, including damage to the immune system induced by immunosuppressive therapy which is reflected in the loss of antibody protection provided by prior immunizations. Our goal was to assess the presence of measles, rubella, and tetanus protective antibody titers among patients with acute lymphoblastic leukemia after completing chemotherapy. Sixty-one children with acute lymphoblastic leukemia seen at the Hospital Garrahan were included; patients had finished their chemotherapy at least 6 months earlier and had a complete immunization schedule before diagnosis. The rates of protective antibodies were 46% (CI: 32-59) for measles, 53% (CI 40-67) for tetanus, and 60% (CI 47-63) for rubella. These results strengthen the need to reconsider revaccination in this group of patients.
authors.affiliation: Hospital de Pediatría SAMIC "Prof. Dr. Juan P. Garrahan", Ciudad Autónoma de Buenos Aires, Argentina. noratelli@yahoo.com.ar.
authors.forename: Myriam
authors.initials: M
authors.lastname: Onorateli
authors.affiliation: Hospital de Pediatría SAMIC "Prof. Dr. Juan P. Garrahan", Ciudad Autónoma de Buenos Aires, Argentina.
authors.forename: Claudia
authors.initials: C
authors.lastname: Botana
authors.affiliation: Hospital de Pediatría SAMIC "Prof. Dr. Juan P. Garrahan", Ciudad Autónoma de Buenos Aires, Argentina.
authors.forename: Laura
authors.initials: L
authors.lastname: Peralta
authors.affiliation: Hospital de Pediatría SAMIC "Prof. Dr. Juan P. Garrahan", Ciudad Autónoma de Buenos Aires, Argentina.
authors.forename: Magali
authors.initials: M
authors.lastname: Rebollo
authors.affiliation: Hospital de Pediatría SAMIC "Prof. Dr. Juan P. Garrahan", Ciudad Autónoma de Buenos Aires, Argentina.
authors.forename: Silvina
authors.initials: S
authors.lastname: Ruvinsky
authors.affiliation: Hospital de Pediatría SAMIC "Prof. Dr. Juan P. Garrahan", Ciudad Autónoma de Buenos Aires, Argentina.
authors.forename: Myriam
authors.initials: M
authors.lastname: Guitter
authors.affiliation: Hospital de Pediatría SAMIC "Prof. Dr. Juan P. Garrahan", Ciudad Autónoma de Buenos Aires, Argentina.
authors.forename: Maria S
authors.initials: MS
authors.lastname: Felice
authors.affiliation: Hospital de Pediatría SAMIC "Prof. Dr. Juan P. Garrahan", Ciudad Autónoma de Buenos Aires, Argentina.
authors.forename: Mercedes
authors.initials: M
authors.lastname: Posadas
authors.affiliation: Hospital de Pediatría SAMIC "Prof. Dr. Juan P. Garrahan", Ciudad Autónoma de Buenos Aires, Argentina.
authors.forename: Silvina
authors.initials: S
authors.lastname: Evangelista
authors.affiliation: Hospital de Pediatría SAMIC "Prof. Dr. Juan P. Garrahan", Ciudad Autónoma de Buenos Aires, Argentina.
authors.forename: Maria V
authors.initials: MV
authors.lastname: Villar
authors.affiliation: Hospital de Pediatría SAMIC "Prof. Dr. Juan P. Garrahan", Ciudad Autónoma de Buenos Aires, Argentina.
authors.forename: Mariana
authors.initials: M
authors.lastname: Golluscio
authors.affiliation: Hospital de Pediatría SAMIC "Prof. Dr. Juan P. Garrahan", Ciudad Autónoma de Buenos Aires, Argentina.
authors.forename: Agustina
authors.initials: A
authors.lastname: Molina
authors.affiliation: Hospital de Pediatría SAMIC "Prof. Dr. Juan P. Garrahan", Ciudad Autónoma de Buenos Aires, Argentina.
authors.forename: Lidia
authors.initials: L
authors.lastname: Fraquelli
mesh_terms: D000293:Adolescent; D000906:Antibodies / Q000097:blood; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D056724:Immunity, Humoral; D008297:Male; D008457:Measles / Q000097:blood / Q000276:immunology*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood / Q000188:drug therapy* / Q000276:immunology*; D012409:Rubella / Q000097:blood / Q000276:immunology*; D013742:Tetanus / Q000097:blood / Q000276:immunology*; D055815:Young Adult
chemical_list: D000906:Antibodies
keywords: Acute lymphoblastic leukemia; Antibodies; Chemotherapy; Humoral immunity; Immunizations