title: Hepatitis C-related cirrhosis. Current status.
abstract: Chronic hepatitis C virus (HCV) infection affects around 150 million people. It is a leading cause of liver related morbidity and mortality through its predisposition to liver fibrosis, cirrhosis and end-stage liver complications. New treatments based on direct-acting antivirals have opened a new era in the management of HCV cirrhosis. They allow for HCV eradication without substantial side effects in almost all cirrhotic patients, reducing the risk of hepatocellular carcinoma, liver decompensation and mortality. This review provides an update on HCV cirrhosis. The paper focuses on the disease burden and major progresses in the diagnosis, follow-up and treatment of this patient subgroup.
authors.affiliation: Unidad de Hepatología y Trasplante Hepático, Servicio de Medicina Digestiva, Hospital Universitario La Fe, Valencia, España; Instituto de Investigación Sanitaria del Hospital Universitario La Fe, Valencia, España. Electronic address: conde_isa@gva.es.
authors.forename: Isabel
authors.initials: I
authors.lastname: Conde
authors.affiliation: Unidad de Hepatología y Trasplante Hepático, Servicio de Medicina Digestiva, Hospital Universitario La Fe, Valencia, España; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid, España.
authors.forename: Carmen
authors.initials: C
authors.lastname: Vinaixa
authors.affiliation: Unidad de Hepatología y Trasplante Hepático, Servicio de Medicina Digestiva, Hospital Universitario La Fe, Valencia, España; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid, España; Facultad de Medicina, Universidad de Valencia, Valencia, España.
authors.forename: Marina
authors.initials: M
authors.lastname: Berenguer
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use; D003131:Combined Modality Therapy; D004359:Drug Therapy, Combination; D014943:Global Health; D019698:Hepatitis C, Chronic / Q000150:complications* / Q000188:drug therapy / Q000453:epidemiology; D006801:Humans; D008103:Liver Cirrhosis / Q000175:diagnosis / Q000628:therapy / Q000821:virology*; D016031:Liver Transplantation; D013030:Spain / Q000453:epidemiology
chemical_list: D000998:Antiviral Agents
keywords: Antivirales de acción directa; Chronic hepatitis C; Cirrosis hepática; Direct-acting antivirals; Hepatitis crónica C; Liver cirrhosis; Liver transplantation; Respuesta viral sostenida; Sustained virological response; Trasplante hepático