title: Astrocytes in Migration.
abstract: Cell migration is a fundamental phenomenon that underlies tissue morphogenesis, wound healing, immune response, and cancer metastasis. Great progresses have been made in research methodologies, with cell migration identified as a highly orchestrated process. Brain is considered the most complex organ in the human body, containing many types of neural cells with astrocytes playing crucial roles in monitoring normal functions of the central nervous system. Astrocytes are mostly quiescent under normal physiological conditions in the adult brain but become migratory after injury. Under most known pathological conditions in the brain, spinal cord and retina, astrocytes are activated and become hypertrophic, hyperplastic, and up-regulating GFAP based on the grades of severity. These three observations are the hallmark in glia scar formation-astrogliosis. The reactivation process is initiated with structural changes involving cell process migration and ended with cell migration. Detailed mechanisms in astrocyte migration have not been studied extensively and remain largely unknown. Here, we therefore attempt to review the mechanisms in migration of astrocytes.
authors.affiliation: Laboratory for Functional Study of Astrocytes, Neuroscience Research Institute, Peking University, 38 Xue Yuan Road, Beijing, 100191, China.|Department of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing, 100191, China.|Key Laboratory for Neuroscience, Ministry of Education, National Health and Family Planning Commission, Peking University Health Science Center, Beijing, 100191, China.
authors.forename: Jiang Shan
authors.initials: JS
authors.lastname: Zhan
authors.affiliation: Laboratory for Functional Study of Astrocytes, Neuroscience Research Institute, Peking University, 38 Xue Yuan Road, Beijing, 100191, China.|Department of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing, 100191, China.|Key Laboratory for Neuroscience, Ministry of Education, National Health and Family Planning Commission, Peking University Health Science Center, Beijing, 100191, China.|Department of Pediatrics, Peking University First Hospital, Beijing, 100034, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Gao
authors.affiliation: Laboratory for Functional Study of Astrocytes, Neuroscience Research Institute, Peking University, 38 Xue Yuan Road, Beijing, 100191, China.|Department of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing, 100191, China.|Key Laboratory for Neuroscience, Ministry of Education, National Health and Family Planning Commission, Peking University Health Science Center, Beijing, 100191, China.|Hai Kang Life (Beijing) Corporation Ltd., Sino-I Campus No.1, Beijing Economic-Technological Development Area, Beijing, 100176, China.
authors.forename: Rui Chao
authors.initials: RC
authors.lastname: Chai
authors.affiliation: Laboratory for Functional Study of Astrocytes, Neuroscience Research Institute, Peking University, 38 Xue Yuan Road, Beijing, 100191, China.|Department of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing, 100191, China.|Key Laboratory for Neuroscience, Ministry of Education, National Health and Family Planning Commission, Peking University Health Science Center, Beijing, 100191, China.|Hai Kang Life (Beijing) Corporation Ltd., Sino-I Campus No.1, Beijing Economic-Technological Development Area, Beijing, 100176, China.
authors.forename: Xi Hua
authors.initials: XH
authors.lastname: Jia
authors.affiliation: Laboratory for Functional Study of Astrocytes, Neuroscience Research Institute, Peking University, 38 Xue Yuan Road, Beijing, 100191, China.|Department of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing, 100191, China.|Key Laboratory for Neuroscience, Ministry of Education, National Health and Family Planning Commission, Peking University Health Science Center, Beijing, 100191, China.|Department of Human Anatomy, Guizhou Medical University, Guian New Area, Guiyang, 550025, Guizhou, China.
authors.forename: Dao Peng
authors.initials: DP
authors.lastname: Luo
authors.affiliation: Laboratory for Functional Study of Astrocytes, Neuroscience Research Institute, Peking University, 38 Xue Yuan Road, Beijing, 100191, China.|Department of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing, 100191, China.|Key Laboratory for Neuroscience, Ministry of Education, National Health and Family Planning Commission, Peking University Health Science Center, Beijing, 100191, China.|Department of Human Anatomy, Guizhou Medical University, Guian New Area, Guiyang, 550025, Guizhou, China.
authors.forename: Guo
authors.initials: G
authors.lastname: Ge
authors.affiliation: Department of Pediatrics, Peking University First Hospital, Beijing, 100034, China.
authors.forename: Yu Wu
authors.initials: YW
authors.lastname: Jiang
authors.affiliation: Laboratory for Functional Study of Astrocytes, Neuroscience Research Institute, Peking University, 38 Xue Yuan Road, Beijing, 100191, China.|Department of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing, 100191, China.|Key Laboratory for Neuroscience, Ministry of Education, National Health and Family Planning Commission, Peking University Health Science Center, Beijing, 100191, China.|Hai Kang Life (Beijing) Corporation Ltd., Sino-I Campus No.1, Beijing Economic-Technological Development Area, Beijing, 100176, China.
authors.forename: Yin-Wan Wendy
authors.initials: YW
authors.lastname: Fung
authors.affiliation: Laboratory for Functional Study of Astrocytes, Neuroscience Research Institute, Peking University, 38 Xue Yuan Road, Beijing, 100191, China. lilina_glia@163.com.|Department of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing, 100191, China. lilina_glia@163.com.|Key Laboratory for Neuroscience, Ministry of Education, National Health and Family Planning Commission, Peking University Health Science Center, Beijing, 100191, China. lilina_glia@163.com.|Hai Kang Life (Beijing) Corporation Ltd., Sino-I Campus No.1, Beijing Economic-Technological Development Area, Beijing, 100176, China. lilina_glia@163.com.
authors.forename: Lina
authors.initials: L
authors.lastname: Li
authors.affiliation: Laboratory for Functional Study of Astrocytes, Neuroscience Research Institute, Peking University, 38 Xue Yuan Road, Beijing, 100191, China. achy@hsc.pku.edu.cn.|Department of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing, 100191, China. achy@hsc.pku.edu.cn.|Key Laboratory for Neuroscience, Ministry of Education, National Health and Family Planning Commission, Peking University Health Science Center, Beijing, 100191, China. achy@hsc.pku.edu.cn.|Laboratory of Translational Medicine, Institute of Systems Biomedicine, Peking University, Beijing, 100191, China. achy@hsc.pku.edu.cn.|Hai Kang Life (Beijing) Corporation Ltd., Sino-I Campus No.1, Beijing Economic-Technological Development Area, Beijing, 100176, China. achy@hsc.pku.edu.cn.
authors.forename: Albert Cheung Hoi
authors.identifier: http://orcid.org/0000-0003-1512-4877
authors.initials: AC
authors.lastname: Yu
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000378:metabolism*; D001921:Brain / Q000166:cytology / Q000378:metabolism; D002448:Cell Adhesion / Q000502:physiology; D002465:Cell Movement / Q000502:physiology*; D002478:Cells, Cultured; D006801:Humans; D013116:Spinal Cord / Q000166:cytology / Q000378:metabolism
keywords: Astrocytes; Cell migration; Injury; Pathological; Physiological; Reactivation