title: A pair of taxifolin-3-O-arabinofuranoside isomers from Juglans regia L.
abstract: Diaphragma juglandis Fructus has been known for its effect on tonifying kidney in traditional Uighur medicine. During our ongoing studies on the discovery of biologically active compounds from folk medicine, a pair of flavanonol glycoside isomers named (2S,3S)-taxifolin-3-O-α-d-arabinofuranoside (1) and (2S,3S)-taxifolin-3-O-α-l-arabinofuranoside (2) were isolated, among them, 1 was a new compound. It is the first report of taxifolin-3-O-arabinofuranosides in both α-d and α-l configuration forms in genus Juglans. Their structures were determined on the basis of spectroscopic analysis and chemical evidence, in combination with circular dichroism.
authors.affiliation: a College of Pharmacy , Shandong University of Traditional Chinese Medicine , Jinan , China.|b Institute of Materia Medica , Shandong Academy of Medical Sciences , Jinan , China.
authors.forename: Huanxin
authors.initials: H
authors.lastname: Zhao
authors.affiliation: c College of Life Science and Technology , Huazhong University of Science and Technology , Wu han , China.
authors.forename: Hong
authors.initials: H
authors.lastname: Bai
authors.affiliation: b Institute of Materia Medica , Shandong Academy of Medical Sciences , Jinan , China.|d School of Medicine and Life Sciences , University of Jinan-Shandong Academy of Medical Sciences , Jinan , China.
authors.forename: Yuanchao
authors.initials: Y
authors.lastname: Jing
authors.affiliation: e Faculty of Pharmaceutical Sciences , Toho University , Funabashi , Japan.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.affiliation: b Institute of Materia Medica , Shandong Academy of Medical Sciences , Jinan , China.|d School of Medicine and Life Sciences , University of Jinan-Shandong Academy of Medical Sciences , Jinan , China.
authors.forename: Shujun
authors.initials: S
authors.lastname: Yin
authors.affiliation: a College of Pharmacy , Shandong University of Traditional Chinese Medicine , Jinan , China.
authors.forename: Honglei
authors.initials: H
authors.lastname: Zhou
mesh_terms: D002942:Circular Dichroism; D005960:Glucosides / Q000737:chemistry* / Q000302:isolation & purification; D006027:Glycosides / Q000737:chemistry; D007536:Isomerism; D031324:Juglans / Q000737:chemistry*; D008519:Medicine, Traditional; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry; D011794:Quercetin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification; D013056:Spectrophotometry, Ultraviolet
chemical_list: C000619975:(2S,3S)-taxifolin-3-O-alpha-D-arabinofuranoside; D005960:Glucosides; D006027:Glycosides; D011794:Quercetin
keywords: Juglans regia L; flavanonol glycoside; isomer