title: Quality of life of patients with recurrent respiratory papillomatosis.
abstract: Recurrent respiratory papillomatosis (RRP) is a disease with a high disease burden. Few studies have assessed quality of life (QoL) of RRP patients. This study compares QoL of these patients with controls. Associations between QoL and sociodemographic and illness-related factors are examined, as is uptake of psychosocial care and speech therapy.
  
  
  
  Prospective cross-sectional questionnaire research.
  
  
  
  Ninety-one RRP patients (response = 67%) from two university hospitals in the Netherlands and Finland completed the following patient reported outcome measures: (HADS), 15-dimensional health-related quality-of-life scale (15D), Voice Handicap Index (VHI) and the RAND 36-item health-related quality-of-life survey instrument (RAND-36) assessing health-related QoL and voice handicap, and they provided sociodemographic, illness-related, and allied healthcare use. Descriptive analyses, χ2tests, t tests, analysis of variance tests, and Pearson correlations were computed to describe the study population and to examine differences between groups.
  
  
  
  RRP patients had significantly higher mean scores on depression, health-related QoL (15D) and on voice problems (VHI), and significantly lower mean scores on anxiety than controls. Dutch patients had more pain and a decreased general health perception (RAND-36) than controls. Dutch patients and older patients were more depressed, women were more anxious, older patients had lower health-related QoL, and smoking was significantly associated with voice handicap. Patients who had received psychosocial care had significantly higher HADS-depression mean scores than patients who did not receive psychosocial care.
  
  
  
  Having RRP has significant effect on voice-related QoL and depression, but has no negative effect on anxiety and health-related QoL. Risk factors for decreased functioning are different than previously hypothesized by many authors. Prevention should be aimed at these risk factors.
  
  
  
  4. Laryngoscope, 127:1826-1831, 2017.
authors.affiliation: Department of Otorhinolaryngology/Head and Neck Surgery, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.|Cancer Research Center, University of Groningen, Groningen, the Netherlands.|Groningen Papilloma Studies, University of Groningen, the Netherlands.
authors.forename: Michel R M
authors.initials: MRM
authors.lastname: San Giorgi
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, University of Helsinki, Helsinki University Hospital, Helsinki, Finland.
authors.forename: Leena-Maija
authors.initials: LM
authors.lastname: Aaltonen
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, University of Helsinki, Helsinki University Hospital, Helsinki, Finland.
authors.forename: Heikki
authors.initials: H
authors.lastname: Rihkanen
authors.affiliation: Department of Otorhinolaryngology/Head and Neck Surgery, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.|Cancer Research Center, University of Groningen, Groningen, the Netherlands.|Groningen Papilloma Studies, University of Groningen, the Netherlands.
authors.forename: Robin E A
authors.initials: REA
authors.lastname: Tjon Pian Gi
authors.affiliation: Department of Otorhinolaryngology/Head and Neck Surgery, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.|Cancer Research Center, University of Groningen, Groningen, the Netherlands.
authors.forename: Bernard F A M
authors.initials: BFAM
authors.lastname: van der Laan
authors.affiliation: Wenckebach Institute, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
authors.forename: Josette E H M
authors.initials: JEHM
authors.lastname: Hoekstra-Weebers
authors.affiliation: Department of Otorhinolaryngology/Head and Neck Surgery, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.|Cancer Research Center, University of Groningen, Groningen, the Netherlands.|Groningen Papilloma Studies, University of Groningen, the Netherlands.
authors.forename: Frederik G
authors.initials: FG
authors.lastname: Dikkers
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D030361:Papillomavirus Infections / Q000150:complications / Q000175:diagnosis / Q000628:therapy; D011446:Prospective Studies; D011788:Quality of Life; D012141:Respiratory Tract Infections / Q000150:complications / Q000175:diagnosis / Q000628:therapy; D057566:Self Report
keywords: Recurrent respiratory papillomatosis; psychosocial distress; quality of life; recurrent respiratory papillomatosis