title: Not all elevated hormones are toxic: A case of thyroid hormone resistance.
abstract: Resistance to thyroid hormone syndrome (RTH) is a rare disorder and is usually inherited as dominantly negative autosomal trait. RTH is caused by mutations in the thyroid hormone receptor beta. Patients with RTH usually do not have signs and symptoms of thyrotoxicosis, but the thyroid function test shows an elevated T3 and T4, which get misinterpreted as hyperthyroidism, resulting in unnecessary treatment.
authors.affiliation: Department of Endocrinology, PIMS, Thiruvalla, Kerala, India.
authors.forename: Rajeev
authors.initials: R
authors.lastname: Philip
authors.affiliation: Department of Family Medicine, PIMS, Thiruvalla, Kerala, India.
authors.forename: Mohan Krishnakumar
authors.initials: MK
authors.lastname: Padikal
authors.affiliation: Department of Medicine, PIMS, Thiruvalla, Kerala, India.
authors.forename: Altaf
authors.initials: A
authors.lastname: Alinausad
authors.affiliation: Department of Medicine, PIMS, Thiruvalla, Kerala, India.
authors.forename: Charamelsankaran
authors.initials: C
authors.lastname: Keshavan
keywords: Neurophysiologic abnormalities; resistance to thyroid hormone syndrome; thyroid hormone receptor beta