title: Light-controllable toxicity recovery from selenium-based amphiphiles.
abstract: A selenium-containing anticancer compound DSeMTTG was prepared, which could be self-assembled into a unimolecular amphiphilic drug nanoassembly (UADN) with good biocompatibility. The resulting UADN was sensitive to singlet oxygen produced by encapsulated porphyrin photosensitizers. Thus, the toxicity of DSeMTTG could be retrieved after visible light irradiation, which significantly inhibited the proliferation of A549 cells without using extra chemotherapeutic drugs.
authors.affiliation: Shanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, 200237, P. R. China. wazhang@ecust.edu.cn.
authors.forename: Hang
authors.initials: H
authors.lastname: Pan
authors.affiliation: Shanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, 200237, P. R. China. wazhang@ecust.edu.cn.
authors.forename: Shangfeng
authors.initials: S
authors.lastname: Wang
authors.affiliation: Shanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, 200237, P. R. China. wazhang@ecust.edu.cn.
authors.forename: Yudong
authors.initials: Y
authors.lastname: Xue
authors.affiliation: Shanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, 200237, P. R. China. wazhang@ecust.edu.cn.
authors.forename: Hongliang
authors.initials: H
authors.lastname: Cao
authors.affiliation: Shanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, 200237, P. R. China. wazhang@ecust.edu.cn.
authors.forename: Weian
authors.initials: W
authors.lastname: Zhang
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008027:Light; D015394:Molecular Structure; D010316:Particle Size; D018036:Selenium Compounds / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013501:Surface-Active Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D018036:Selenium Compounds; D013501:Surface-Active Agents