title: Intra-myocardial growth hormone administration ameliorates arrhythmogenesis during ischemia-reperfusion in rats.
abstract: Growth hormone, currently under evaluation for the prevention of left ventricular remodeling post-myocardial infarction, displays antiarrhythmic properties in the acute setting. However, it is uncertain whether these actions are retained after ischemia/reperfusion. Using implanted telemetry transmitters, we examined the effects of prolonged, intra-myocardial growth hormone administration in conscious rats. During a 24-h observation period, ventricular tachyarrhythmias and sympathetic activation were attenuated in treated rats, whereas infarct-size was unchanged. These findings call for further study on the antiarrhythmic effects of growth hormone and on the underlying mechanisms.
authors.affiliation: Department of Cardiology, Medical School, University of Ioannina, Greece; Cardiovascular Research Institute, Ioannina, Greece.
authors.forename: Marianthi
authors.initials: M
authors.lastname: Kontonika
authors.affiliation: Cardiovascular Research Institute, Ioannina, Greece; Ceramics and Composites Laboratory, Department of Materials Science and Engineering, University of Ioannina, Greece.
authors.forename: Eleonora
authors.initials: E
authors.lastname: Barka
authors.affiliation: Cardiovascular Research Institute, Ioannina, Greece; Ceramics and Composites Laboratory, Department of Materials Science and Engineering, University of Ioannina, Greece.
authors.forename: Maria
authors.initials: M
authors.lastname: Roumpi
authors.affiliation: Department of Cardiology, Medical School, University of Ioannina, Greece.
authors.forename: Agapi D
authors.initials: AD
authors.lastname: Vilaeti
authors.affiliation: Cardiovascular Research Institute, Ioannina, Greece.
authors.forename: Giannis G
authors.initials: GG
authors.lastname: Baltogiannis
authors.affiliation: Pediatric Cardiology, Sector of Child Health, Medical School, University of Ioannina, Greece.
authors.forename: Antonios P
authors.initials: AP
authors.lastname: Vlahos
authors.affiliation: Cardiovascular Research Institute, Ioannina, Greece.
authors.forename: Simeon
authors.initials: S
authors.lastname: Agathopoulos
authors.affiliation: Department of Cardiology, Medical School, University of Ioannina, Greece; Cardiovascular Research Institute, Ioannina, Greece. Electronic address: theofilos.m.kolettis@gmail.com.
authors.forename: Theofilos M
authors.initials: TM
authors.lastname: Kolettis
mesh_terms: D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage; D013006:Growth Hormone / Q000008:administration & dosage*; D015428:Myocardial Reperfusion Injury / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy*; D051381:Rats; D017208:Rats, Wistar; D017180:Tachycardia, Ventricular / Q000150:complications* / Q000175:diagnosis / Q000517:prevention & control*; D016896:Treatment Outcome
chemical_list: D000889:Anti-Arrhythmia Agents; D013006:Growth Hormone
keywords: Growth hormone; Ischemia; Reperfusion; Scaffold; Sympathetic activation; Ventricular arrhythmias