title: Postprandial dysmetabolism: Too early or too late?
abstract: Postprandial dysmetabolism is a postprandial state characterized by abnormal metabolism of glucose and lipids and, more specifically, of elevated levels of glucose and triglyceride (TG) containing lipoproteins. Since there is evidence that postprandial dysmetabolism is associated with increased cardiovascular mortality and morbidity, due to macro- and microvascular complications, as well as with conditions such as polycystic ovary syndrome (PCOS) and non-alcoholic fatty liver disease (NAFLD), it is recommended that clinicians be alert for early detection and management of this condition. Management consists of a holistic approach including dietary modification, exercise and use of hypoglycemic and hypolipidemic medication aiming to decrease the postprandial values of circulating glucose and triglycerides. This review aims to explain glucose and lipid homeostasis and the impact of postprandial dysmetabolism on the cardiovascular system as well as to offer suggestions with regard to the therapeutic approach for this entity. However, more trials are required to prevent or reverse early and not too late the actual tissue damage due to postprandial dysmetabolism.
authors.affiliation: Department of Endocrinology and Diabetes Center of Excellence, EUROCLINIC, Athens, Greece.
authors.forename: Christos
authors.initials: C
authors.lastname: Pappas
authors.affiliation: Endocrine Unit 3rd Department of Medicine, University of Athens Medical School, Athens, Greece.
authors.forename: Eleni A
authors.initials: EA
authors.lastname: Kandaraki
authors.affiliation: Department of Endocrinology and Diabetes Center of Excellence, EUROCLINIC, Athens, Greece.
authors.forename: Sofia
authors.initials: S
authors.lastname: Tsirona
authors.affiliation: Department of Medicine Hepatology Unit, Hygeia Hospital, Athens, Greece.
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Kountouras
authors.affiliation: Endocrine Unit 3rd Department of Medicine, University of Athens Medical School, Athens, Greece.
authors.forename: Georgia
authors.initials: G
authors.lastname: Kassi
authors.affiliation: Department of Endocrinology and Diabetes Center of Excellence, EUROCLINIC, Athens, Greece. e.diamanti.kandarakis@gmail.com.
authors.forename: Evanthia
authors.initials: E
authors.lastname: Diamanti-Kandarakis
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism*; D002318:Cardiovascular Diseases / Q000209:etiology; D006801:Humans; D006943:Hyperglycemia / Q000097:blood* / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D015228:Hypertriglyceridemia / Q000097:blood* / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D008074:Lipoproteins / Q000097:blood; D019518:Postprandial Period; D011237:Predictive Value of Tests; D011379:Prognosis; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood*
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D008074:Lipoproteins; D014280:Triglycerides