title: [ANMCO/ELAS/SIBioC Consensus document: Recommendations for the use of cardiac biomarkers in heart failure patients].
abstract: Biomarkers have dramatically impacted the way heart failure (HF) patients are evaluated and managed. A biomarker is a characteristic that is objectively measured and evaluated as an indicator of normal biological or pathogenic processes, or pharmacological responses to a therapeutic intervention. Natriuretic peptides (B-type natriuretic peptide [BNP] and N-terminal proBNP) are the gold standard biomarkers in determining the diagnosis and prognosis of HF, and a natriuretic peptide-guided HF management looks promising. In the last few years, an array of additional biomarkers has emerged, each reflecting different pathophysiological processes in the development and progression of HF: myocardial insult, inflammation, fibrosis and remodeling, but their role in the clinical care of the patient is still partially defined and more studies are needed before to be well validated. Moreover, several new biomarkers have the potential to identify patients with early renal dysfunction and appear to have promise to help the management cardio-renal syndrome.With different biomarkers reflecting HF presence, the various pathways involved in its progression, as well as identifying unique treatment options for HF management, a closer cardiologist-laboratory link, with a multi-biomarker approach to the HF patient, is not far ahead, allowing the unique opportunity for specifically tailoring care to the individual pathological phenotype.
authors.affiliation: U.O.C. Cardiologia-UTIC, Presidio Ospedaliero San Filippo Neri, Roma.
authors.forename: Nadia
authors.initials: N
authors.lastname: Aspromonte
authors.affiliation: U.O.C. Cardiologia, Ospedale Garibaldi-Nesima, Azienda di Rilievo Nazionale e Alta Specializzazione "Garibaldi", Catania.
authors.forename: Michele Massimo
authors.initials: MM
authors.lastname: Gulizia
authors.affiliation: Laboratorio di Endocrinologia Cardiovascolare e Biologia Cellulare, Fondazione Toscana G. Monasterio-CNR, Scuola Superiore Sant'Anna, Pisa.
authors.forename: Aldo
authors.initials: A
authors.lastname: Clerico
authors.affiliation: U.O. Cardiologia, Istituti Ospitalieri, Cremona.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Di Tano
authors.affiliation: Cardiologia e Medicina Cardiovascolare, Fondazione Toscana G. Monasterio, Pisa.
authors.forename: Michele
authors.initials: M
authors.lastname: Emdin
authors.affiliation: Riabilitazione Cardiologica - Unità Scompenso Cardiaco, Ospedale Maggiore SS. Trinità, Fossano (CN).
authors.forename: Mauro
authors.initials: M
authors.lastname: Feola
authors.affiliation: U.O. Cardiologia Universitaria, Ospedale Policlinico, Bari.
authors.forename: Massimo
authors.initials: M
authors.lastname: Iacoviello
authors.affiliation: Dipartimento di Ricerca Cardiovascolare, Istituto Mario Negri, Milano.
authors.forename: Roberto
authors.initials: R
authors.lastname: Latini
authors.affiliation: U.O. Cardiologia Clinica e Scompenso Cardiaco, Policlinico di Monza, Monza (MB).
authors.forename: Andrea
authors.initials: A
authors.lastname: Mortara
authors.affiliation: U.O.C. Cardiologia, Ospedale Civile, Chioggia (VE).
authors.forename: Roberto
authors.initials: R
authors.lastname: Valle
authors.affiliation: U.O.C. Cardiologia, Ospedale SS. Annunziata, Cosenza.
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Misuraca
authors.affiliation: Cardiologia e Medicina Cardiovascolare, Fondazione Toscana G. Monasterio, Pisa.
authors.forename: Claudio
authors.initials: C
authors.lastname: Passino
authors.affiliation: Dipartimento di Ricerca Cardiovascolare, Istituto Mario Negri, Milano.
authors.forename: Serge
authors.initials: S
authors.lastname: Masson
authors.affiliation: Cardiologia e Medicina Cardiovascolare, Fondazione Toscana G. Monasterio, Pisa.
authors.forename: Alberto
authors.initials: A
authors.lastname: Aimo
authors.affiliation: Sezione Biochimica Clinica e Medicina Molecolare Clinica, Dipartimento di Biopatologia e Biotecnologie Mediche, Università degli Studi, Palermo.
authors.forename: Marcello
authors.initials: M
authors.lastname: Ciaccio
authors.affiliation: S.C. Laboratorio Analisi, A.O. Ordine Mauriziano, Torino.
authors.forename: Marco
authors.initials: M
authors.lastname: Migliardi
mesh_terms: D015415:Biomarkers / Q000097:blood; D001774:Blood Chemical Analysis / Q000379:methods; D006333:Heart Failure / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D006439:Hemodynamics; D006801:Humans; D045265:Natriuretic Peptides / Q000097:blood; D011379:Prognosis; D013312:Stress, Physiological
chemical_list: D015415:Biomarkers; D045265:Natriuretic Peptides