title: Lack of Associations betweenXPCGene Polymorphisms and Neuroblastoma Susceptibility in a Chinese Population.
abstract: Neuroblastoma is one of the most malignant solid tumors in infants and young children. No more than 40% of neuroblastoma patients can survive for longer than five years after it has been diagnosed. XPC protein is a pivotal factor that recognizes DNA damage and starts up the nucleotide excision repair (NER) in mammalian cells. This makes up the first group to defend against the cancer. Previous studies have identified thatXPCgene polymorphisms were associated with various types of cancer. However, the associations betweenXPCgene polymorphisms and neuroblastoma risk have not yet been studied. We investigated the associations between threeXPCgene polymorphisms (rs2228001 A>C, rs2228000 C>T, and rs2229090 G>C) and neuroblastoma risk with 256 neuroblastoma patients and 531 healthy controls in a Chinese Han population. Odds ratios and 95% confidence intervals were used to access the association between these three polymorphisms and neuroblastoma risk. No significant association was detected between these three polymorphisms and neuroblastoma risk in the overall analysis as well as in the stratification analysis. These results suggest that none of these three polymorphisms may be associated with the risk of neuroblastoma in the Chinese Han population.
authors.affiliation: Department of Pediatric Surgery, Foshan Maternity and Children's Healthcare Hospital Affiliated to Southern Medical University, Foshan, China; Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong 510623, China.
authors.forename: Jintao
authors.initials: J
authors.lastname: Zheng
authors.affiliation: Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong 510623, China.
authors.forename: Ruizhong
authors.initials: R
authors.lastname: Zhang
authors.affiliation: Molecular Epidemiology Laboratory and Department of Laboratory Medicine, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang 150040, China.
authors.forename: Jinhong
authors.initials: J
authors.lastname: Zhu
authors.affiliation: Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong 510623, China.
authors.forename: Fenghua
authors.initials: F
authors.lastname: Wang
authors.affiliation: Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong 510623, China.
authors.forename: Tianyou
authors.initials: T
authors.lastname: Yang
authors.affiliation: Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong 510623, China.
authors.forename: Jing
authors.identifier: 0000-0002-1954-2892
authors.initials: J
authors.lastname: He
authors.affiliation: Department of Pediatric Surgery, Foshan Maternity and Children's Healthcare Hospital Affiliated to Southern Medical University, Foshan, China; Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong 510623, China.
authors.forename: Huimin
authors.identifier: 0000-0002-0103-1672
authors.initials: H
authors.lastname: Xia
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D009447:Neuroblastoma / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D018570:Risk Assessment
chemical_list: D004268:DNA-Binding Proteins; C086984:XPC protein, human