title: Systemic Toxicity of Intraperitoneal Vancomycin.
abstract: Intraperitoneal vancomycin is used for empiric treatment of peritoneal dialysis peritonitis. It is dosed intermittently and a high systemic concentration is often achieved. Despite this, there are very few reports of systemic toxicity from intraperitoneal vancomycin. We report the course of a patient who developed a drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome after three weeks of intraperitoneal vancomycin. We review the literature and conclude that this is the first ever reported case of DRESS syndrome from intraperitoneal vancomycin.
authors.affiliation: Division of Nephrology, Department of Medicine, University of Ottawa and The Ottawa Hospital, Ottawa, ON, Canada; Kidney Research Centre, University of Ottawa, Ottawa, ON, Canada.
authors.forename: Teerath
authors.initials: T
authors.lastname: Kumar
authors.affiliation: Department of Pathology, University of Ottawa and The Ottawa Hospital, Ottawa, ON, Canada.
authors.forename: Iris
authors.initials: I
authors.lastname: Teo
authors.affiliation: Division of Nephrology, Department of Medicine, University of Ottawa and The Ottawa Hospital, Ottawa, ON, Canada; Kidney Research Centre, University of Ottawa, Ottawa, ON, Canada.
authors.forename: Brendan B
authors.identifier: 0000-0003-1307-9654
authors.initials: BB
authors.lastname: McCormick