title: Role of Recombinant Human Bone Morphogenetic Protein-2 on Hindfoot Arthrodesis.
abstract: Despite advances in understanding bone healing physiology and surgical techniques, delayed union and nonunion still occur after the treatment of hindfoot arthrodesis. There is increasing appeal of bone morphogenetic proteins (BMPs) owing to the innate osteoinductive abilities of BMPs. Effective treatment with BMPs has been shown in animal studies. Human clinical studies have also shown success. The only study investigating the use of recombinant human BMP (rhBMP)-2 in hindfoot arthrodesis found a significant increase in fusion rate. Treatment cost effective. Complications from their use remain low. rhBMP-2 is a safe and effective bone-healing adjunct in hindfoot arthrodesis surgery.
authors.affiliation: Department of Orthopaedics, Rutgers New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA.
authors.forename: Jeremy
authors.initials: J
authors.lastname: Hreha
authors.affiliation: Department of Orthopaedics, Rutgers New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA.
authors.forename: Ethan S
authors.initials: ES
authors.lastname: Krell
authors.affiliation: Department of Orthopaedics, The Rubin Institute for Advanced Orthopaedics at Sinai Hospital, 2401 West Belvedere Avenue, Baltimore, MD 21215, USA. Electronic address: drchrisbibbo@gmail.com.
authors.forename: Christopher
authors.initials: C
authors.lastname: Bibbo
mesh_terms: D000818:Animals; D001174:Arthrodesis / Q000009:adverse effects / Q000379:methods*; D050071:Bone Density Conservation Agents / Q000494:pharmacology / Q000627:therapeutic use*; D055396:Bone Morphogenetic Protein 2 / Q000494:pharmacology / Q000627:therapeutic use*; D019485:Bone Morphogenetic Proteins / Q000494:pharmacology / Q000627:therapeutic use; D016025:Bone Transplantation; D005528:Foot / Q000601:surgery*; D017102:Fracture Healing / Q000187:drug effects*; D005599:Fractures, Ununited / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D023421:Models, Animal; D011994:Recombinant Proteins / Q000494:pharmacology / Q000627:therapeutic use; D016212:Transforming Growth Factor beta / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D050071:Bone Density Conservation Agents; D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins; D011994:Recombinant Proteins; D016212:Transforming Growth Factor beta; C499469:recombinant human bone morphogenetic protein-2
keywords: Arthrodesis; Fusion; Hindfoot; Orthobiologics; rhBMP-2