title: Benefits, Potential Harms, and Optimal Use of Nutritional Supplementation for Preventing Progression of Age-Related Macular Degeneration.
abstract: OBJECTIVE
  To briefly review age-related macular degeneration (AMD), the main findings from the Age Related Eye Disease Study (AREDS) report number 8 on the use of nutritional supplements for AMD, and to focus on data suggesting that supplement use should be guided using genetic testing of AMD risk genes.
  
  
  METHODS
  A literature search (January 2001 through October 26, 2016) was conducted using MEDLINE and the following MeSH terms: Antioxidants/therapeutic use, Genotype, Macular Degeneration/drug therapy, Macular degeneration/genetics, Dietary Supplements, Proteins/genetics, and Zinc Compounds/therapeutic use. Bibliographies of publications identified were also reviewed.
  
  
  METHODS
  English-language studies assessing AREDS supplement response in patients with AMD in relation to complement factor H gene ( CFH) and age-related maculopathy susceptibility 2 gene ( ARMS2) risk alleles were evaluated.
  
  
  RESULTS
  Three of the 4 studies demonstrated a treatment interaction between ARMS2 and CFH genotypes and a differential response to supplements. The fourth study documented an interaction for the CFH genotype only. Reported response interactions included attenuated response, no response, and good response, whereas a subset showed increased progression of AMD. Conversely, one study reported no interactions between CFH and ARMS2 risk alleles and response to supplements.
  
  
  CONCLUSIONS
  The weight of the evidence supports using genetic testing to guide selection of ocular vitamin use. This approach will avoid using supplements that could speed the progression of AMD in vulnerable patients, avoid using supplements that will have little to no effect in others, and result in appropriately using supplements in those that are likely to derive meaningful benefits.
authors.affiliation: 1 CRF Consulting, Waterloo, ON, Canada.|2 McMaster University, Hamilton, ON, Canada.
authors.forename: Carlos H
authors.initials: CH
authors.lastname: Rojas-Fernandez
authors.affiliation: 3 Optometrist, Ajax, ON, Canada.
authors.forename: Kevin
authors.initials: K
authors.lastname: Tyber
mesh_terms: D000483:Alleles; D000975:Antioxidants / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D017242:Complement Factor H / Q000235:genetics; D019587:Dietary Supplements; D018450:Disease Progression; D004305:Dose-Response Relationship, Drug; D005260:Female; D005838:Genotype; D006801:Humans; D008268:Macular Degeneration / Q000188:drug therapy* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011506:Proteins / Q000235:genetics*; D012307:Risk Factors; D016896:Treatment Outcome; D014815:Vitamins / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: C514392:ARMS2 protein, human; D000975:Antioxidants; C493495:CFH protein, human; D011506:Proteins; D014815:Vitamins; D017242:Complement Factor H
keywords: Aging; Drug Safety; Nutrition; Opthalmology; Pharmacogenetics and Pharmacogenomics