title: A Power Calculator for the Classical Twin Design.
abstract: Power is a ubiquitous, though often overlooked, component of any statistical analyses. Almost every funding agency and institutional review board requires that some sort of power analysis is conducted prior to data collection. While there are several excellent on line power calculators for independent observations, twin studies pose unique challenges that are not incorporated into these algorithms. The goal of the current manuscript is to outline a general method for calculating power in twin studies, and to provide functions to allow researchers to easily conduct power analyses for a range of common twin models. Several scenarios are discussed to demonstrate the importance of various factors that influence the power within the classical twin design and to serve as examples for the provided functions.
authors.affiliation: Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA. brad.verhulst@gmail.com.
authors.forename: Brad
authors.identifier: 0000-0001-5369-9757
authors.initials: B
authors.lastname: Verhulst
mesh_terms: D000465:Algorithms; D006801:Humans; D008957:Models, Genetic; D013223:Statistics as Topic / Q000379:methods*; D014427:Twins / Q000706:statistics & numerical data*
keywords: Biometrical genetics; Power; Twin study; Variance components