title: Molecular Imaging and Precision Medicine in Prostate Cancer.
abstract: The aim of the present review is to discuss about the role of new probes for molecular imaging in the evaluation of prostate cancer (PCa). This review focuses particularly on the role of new promising radiotracers for the molecular imaging with PET/computed tomography in the detection of PCa recurrence. The role of these new imaging techniques to guide lesion-target therapies and the potential application of these molecular probes as theranostics agents is discussed. Finally, the molecular mechanisms underlying resistance to castration in PCa and the maintenance of active androgen receptor are discussed.
authors.affiliation: Service of Nuclear Medicine, S. Orsola-Malpighi University Hospital, University of Bologna, Via Massarenti 9, Bologna 40138, Italy. Electronic address: francesco.ceci@studio.unibo.it.
authors.forename: Francesco
authors.initials: F
authors.lastname: Ceci
authors.affiliation: Department of Pathology, S. Orsola-Malpighi University Hospital, University of Bologna, Via Massarenti 9, Bologna 40138, Italy.
authors.forename: Michelangelo
authors.initials: M
authors.lastname: Fiorentino
authors.affiliation: Service of Nuclear Medicine, S. Orsola-Malpighi University Hospital, University of Bologna, Via Massarenti 9, Bologna 40138, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Castellucci
authors.affiliation: Service of Nuclear Medicine, S. Orsola-Malpighi University Hospital, University of Bologna, Via Massarenti 9, Bologna 40138, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Fanti
mesh_terms: D014408:Biomarkers, Tumor; D006801:Humans; D008297:Male; D057054:Molecular Imaging; D058990:Molecular Targeted Therapy; D000072078:Positron Emission Tomography Computed Tomography / Q000379:methods*; D057285:Precision Medicine; D011237:Predictive Value of Tests; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging* / Q000628:therapy*; D019275:Radiopharmaceuticals; D011944:Receptors, Androgen / Q000502:physiology
chemical_list: D014408:Biomarkers, Tumor; D019275:Radiopharmaceuticals; D011944:Receptors, Androgen
keywords: (68)Ga-PSMA PET/CT; Androgen receptor; Biochemical relapse; Castrate resistant prostate cancer; Prostate cancer