title: Changes in the Dose-Response Relationship of One Toxicant Under Simultaneous Exposure to Another Toxicant.
abstract: We considered, in general form for a 22full factorial experiment, linear approximations of the organism's dose-response relationship for some factors operating alone and modification of this relationship by another factor operating in the background. A typological classification of such modifications is suggested. An analysis of the outcomes obtained in a number of subchronic animal experiments on rats in which this response was assessed by changes in a large number of biomedical indices revealed that all theoretically possible variants (types) of the modification under consideration are actually observed depending on a specific index and specific harmful exposure. Statistical significance estimation procedures are formulated for each of them.
authors.affiliation: The Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, Ekaterinburg, Russia.
authors.forename: B A
authors.initials: BA
authors.lastname: Katsnelson
authors.affiliation: Institute of Industrial Ecology, The Urals Branch of the Russian Academy of Sciences, Ekaterinburg, Russia.
authors.forename: V G
authors.initials: VG
authors.lastname: Panov
authors.affiliation: Institute of Industrial Ecology, The Urals Branch of the Russian Academy of Sciences, Ekaterinburg, Russia.
authors.forename: A N
authors.initials: AN
authors.lastname: Varaksin
authors.affiliation: The Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, Ekaterinburg, Russia.
authors.forename: I A
authors.initials: IA
authors.lastname: Minigalieva
authors.affiliation: The Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, Ekaterinburg, Russia.
authors.forename: L I
authors.initials: LI
authors.lastname: Privalova
authors.affiliation: The Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, Ekaterinburg, Russia.
authors.forename: M P
authors.initials: MP
authors.lastname: Sutunkova
keywords: animal experiments; combined toxicity; interaction plots; toxic metals