title: Therapeutic drug monitoring in the past 40 years of the Journal of Antimicrobial Chemotherapy.
abstract: Since the Journal of Antimicrobial Chemotherapy was first published in 1975, papers addressing therapeutic drug monitoring (TDM) have been a regular feature. Initially they focused on laboratory aspects of drug concentration measurement then they changed more to the application of TDM in a clinical setting. Over its history, the Journal has provided its readership with the latest technological and scientific advances in TDM and has helped to drive changes in TDM that have directly impacted on patient care. These have varied from improvement in the quality of antimicrobial measurements through better identification of dosage regimens and TDM targets that help predict outcome and adverse events. Despite these advances in our understanding of the science and practice of TDM, there remain many areas of uncertainty. As we move into the next 40 years, it is clear that the Journal will continue to provide the readership with the latest science and opinion in this important area.
authors.affiliation: Antimicrobial Reference Laboratory, Severn Infection Sciences Partnership, Southmead Hospital, Bristol BS10 5NB, UK.
authors.forename: David
authors.initials: D
authors.lastname: Reeves
authors.affiliation: Antimicrobial Reference Laboratory, Severn Infection Sciences Partnership, Southmead Hospital, Bristol BS10 5NB, UK andrew.lovering@nbt.nhs.uk.
authors.forename: Andrew
authors.initials: A
authors.lastname: Lovering
authors.affiliation: Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow G4 0RE, UK.
authors.forename: Alison
authors.initials: A
authors.lastname: Thomson
mesh_terms: D000890:Anti-Infective Agents / Q000627:therapeutic use*; D003141:Communicable Diseases / Q000188:drug therapy*; D016903:Drug Monitoring / Q000379:methods* / Q000639:trends*; D006801:Humans
chemical_list: D000890:Anti-Infective Agents