title: Predicting the physiological response of Tivela stultorum hearts with digoxin from cardiac parameters using artificial neural networks.
abstract: Multi-layer perceptron artificial neural networks (MLP-ANNs) were used to predict the concentration of digoxin needed to obtain a cardio-activity of specific biophysical parameters in Tivela stultorum hearts. The inputs of the neural networks were the minimum and maximum values of heart contraction force, the time of ventricular filling, the volume used for dilution, heart rate and weight, volume, length and width of the heart, while the output was the digoxin concentration in dilution necessary to obtain a desired physiological response. ANNs were trained, validated and tested with the dataset of the in vivo experiment results. To select the optimal network, predictions for all the dataset for each configuration of ANNs were made, a maximum 5% relative error for the digoxin concentration was set and the diagnostic accuracy of the predictions made was evaluated. The double-layer perceptron had a barely higher performance than the single-layer perceptron; therefore, both had a good predictive ability. The double-layer perceptron was able to obtain the most accurate predictions of digoxin concentration required in the hearts of T. stultorum using MLP-ANNs.
authors.affiliation: Autonomous University of Baja California, Ensenada, Baja California 22860, Mexico. Electronic address: dflores@uabc.edu.mx.
authors.forename: Dora-Luz
authors.initials: DL
authors.lastname: Flores
authors.affiliation: Autonomous University of Baja California, Ensenada, Baja California 22860, Mexico.
authors.forename: Claudia
authors.initials: C
authors.lastname: Gómez
authors.affiliation: Autonomous University of Baja California, Ensenada, Baja California 22860, Mexico.
authors.forename: David
authors.initials: D
authors.lastname: Cervantes
authors.affiliation: Autonomous University of Baja California, Ensenada, Baja California 22860, Mexico.
authors.forename: Alberto
authors.initials: A
authors.lastname: Abaroa
authors.affiliation: Autonomous University of Baja California, Ensenada, Baja California 22860, Mexico.
authors.forename: Carlos
authors.initials: C
authors.lastname: Castro
authors.affiliation: Autonomous University of Baja California, Ensenada, Baja California 22860, Mexico.
authors.forename: Rubén A
authors.initials: RA
authors.lastname: Castañeda-Martínez
mesh_terms: D000465:Algorithms; D000818:Animals; D049872:Bivalvia / Q000187:drug effects* / Q000502:physiology; D002316:Cardiotonic Agents / Q000494:pharmacology; D004077:Digoxin / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D008955:Models, Cardiovascular; D009200:Myocardial Contraction / Q000187:drug effects / Q000502:physiology; D016571:Neural Networks, Computer; D012815:Signal Processing, Computer-Assisted
chemical_list: D002316:Cardiotonic Agents; D004077:Digoxin
keywords: Artificial neural networks; Cardio-activity; Digitalis; Digoxin; Drug response; Tivela stultorum