title: Survival prediction of anxious emotion in advanced cancer patients receiving palliative care.
abstract: BACKGROUND
  This study was carried out to investigate the prognostic value of baseline and dynamic changes in anxious emotion in advanced cancer patients undergoing palliative care.
  
  
  METHODS
  The association between anxious emotion and survival was investigated in a retrospective sample of 377 consecutive advanced cancer patients receiving palliative care from August 2013 to October 2015 and in an extended follow-up study of 106 of those patients.
  
  
  RESULTS
  The prevalence of anxious emotion was 24.93% (94/377) overall, 22.48% (47/209) in men and 27.97% (47/168) in women. Significant associations between baseline anxious emotion and overall survival (OS) were not found in the whole sample or in women. However, univariate and multivariate analyses showed that anxious emotion was an independent prognostic indicator of OS in men (hazard ratio [HR]: 1.811, P = .003). Moreover, findings showed that newly developed anxious emotion was significantly associated with poor OS in all readmitted patients (HR: 5.568, P < .001), in men (HR: 5.104, P = .006) and women (HR: 5.820, P = .004).
  
  
  CONCLUSIONS
  Our study suggests that anxious emotion, especially dynamic changes in anxious emotion, needs to be monitored in advanced cancer patients; whether targeted interventions would prolong survival requires further studies.
authors.affiliation: Department of Integrated Therapy, Fudan University Shanghai Cancer Center, Shanghai, China.|Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
authors.forename: Weiwei
authors.initials: W
authors.lastname: Zhao
authors.affiliation: Department of Biostatistics, School of Public Health, Key Laboratory of Public Health Safety, Ministry of Education, Fudan University, Shanghai, China.
authors.forename: Zhenyu
authors.initials: Z
authors.lastname: Wu
authors.affiliation: Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Jianhua
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
authors.forename: Huixun
authors.initials: H
authors.lastname: Jia
authors.affiliation: Department of Integrated Therapy, Fudan University Shanghai Cancer Center, Shanghai, China.
authors.forename: Zhe
authors.initials: Z
authors.lastname: Huang
authors.affiliation: Department of Integrated Therapy, Fudan University Shanghai Cancer Center, Shanghai, China.
authors.forename: Menglei
authors.initials: M
authors.lastname: Chen
authors.affiliation: Department of Integrated Therapy, Fudan University Shanghai Cancer Center, Shanghai, China.
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Gu
authors.affiliation: Department of Integrated Therapy, Fudan University Shanghai Cancer Center, Shanghai, China.
authors.forename: Minghui
authors.initials: M
authors.lastname: Liu
authors.affiliation: Department of Integrated Therapy, Fudan University Shanghai Cancer Center, Shanghai, China.
authors.forename: Zhe
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Integrated Therapy, Fudan University Shanghai Cancer Center, Shanghai, China.
authors.forename: Huaping
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.|Department of Integrative Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Wang
authors.affiliation: Department of Integrated Therapy, Fudan University Shanghai Cancer Center, Shanghai, China.|Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
authors.forename: Wenwu
authors.initials: W
authors.lastname: Cheng
mesh_terms: D000328:Adult; D000368:Aged; D001007:Anxiety / Q000175:diagnosis / Q000523:psychology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009369:Neoplasms / Q000188:drug therapy* / Q000401:mortality; D010166:Palliative Care; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies
keywords: advanced cancer; anxious emotion; oncology; palliative care; prognostic value