title: [Neural basis of social cognition in bipolar disorder].
abstract: OBJECTIVE
  This article review studies social and interpersonal functioning in patients with bipolar disorder (BD), and reports on the neurobiological underpinnings of the dysfunctions in emotion recognition, i.e. one of the main domains of social cognition.
  
  
  METHODS
  A bibliographical research of controlled studies from 1967 to 2015 was completed in PubMed and PsycINFO using the keywords: "fMRI", "emotion comprehension", "emotion perception", "affect comprehension", "affect perception", "facial expression", "prosody", "theory of mind", "mentalizing", "attributional style", "social perception", "empathy" and "bipolar disorder" or "unipolar depression".
  
  
  RESULTS
  Limbic hyperactivity, with a lack of appropriate cortical control, has been reported in subjects with BD during social interactions. This is particularly evident during the acute affective episodes but may persist during the euthymic phases.
  
  
  CONCLUSIONS
  Deficits in emotion regulation, including neural systems implicated both in voluntary and automatic emotion regulatory subprocesses, are present in DB, particularly for what pertains to social interactions and interpersonal functioning.
  
  
  CONCLUSIONS
  Patients with bipolar disorder may present a dysfunction in the cortical ability to modulate the limbic system, which may show hyperactivity during social interactions. More studies are needed, including studies to evaluate treatment implications.
authors.affiliation: Scuola Cognitiva, Firenze.
authors.forename: Filippo
authors.initials: F
authors.lastname: Turchi
authors.affiliation: Dipartimento di Medicina Molecolare, Università di Siena.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Amodeo
authors.affiliation: Servizio Psichiatrico, Bressanone (Bolzano).
authors.forename: Ettore
authors.initials: E
authors.lastname: Favaretto
authors.affiliation: Scuola Cognitiva, Firenze.
authors.forename: Stefania
authors.initials: S
authors.lastname: Righini
authors.affiliation: Scuola Cognitiva, Firenze.
authors.forename: Eugenia
authors.initials: E
authors.lastname: Mellina
authors.affiliation: Scuola Cognitiva, Firenze.
authors.forename: Carmelo
authors.initials: C
authors.lastname: La Mela
authors.affiliation: Dipartimento di Medicina Molecolare, Università di Siena.
authors.forename: Andrea
authors.initials: A
authors.lastname: Fagiolini
mesh_terms: D000293:Adolescent; D001714:Bipolar Disorder / Q000188:drug therapy / Q000453:epidemiology / Q000523:psychology*; D002540:Cerebral Cortex / Q000503:physiopathology*; D002648:Child; D015897:Comorbidity; D004644:Emotions; D000066499:Facial Recognition / Q000187:drug effects / Q000502:physiology; D006801:Humans; D007398:Interpersonal Relations; D008032:Limbic System / Q000503:physiopathology*; D008279:Magnetic Resonance Imaging; D001523:Mental Disorders / Q000453:epidemiology / Q000523:psychology; D009434:Neural Pathways; D011619:Psychotropic Drugs / Q000494:pharmacology / Q000627:therapeutic use; D012938:Social Perception
chemical_list: D011619:Psychotropic Drugs