title: Correlation between maternal serum-amniotic fluid anti-angiogenic factors and uterine artery Doppler indices.
abstract: OBJECTIVE
  Elevated sFlt-1 and sEng is usually a clue for impending preeclampsia and intrauterine growth restriction. Likewise, uterine artery Doppler ultrasound is being investigated for prediction of similar conditions. In this study, we aimed to explore the possible relations of these two proteins in different body compartments with uterine artery Doppler indices (UtAD) in a healthy second trimester obstetric population.
  
  
  METHODS
  Levels of sFlt-1 and sEng were measured in serum and amniotic fluid samples of 43 patients. UtAD were measured on the days of sample collections. Findings were then analyzed for possible correlation.
  
  
  RESULTS
  There was a positive correlation between the levels of maternal serum sFlt-1 (MSsFlt-1) and sEng levels (MSsEng) (r= 0.516, p< 0.001). The negative correlation between MSsFlt-1 and UtAD was disappeared after elimination of poor obstetric outcome pregnancies (r= -0.371, p= 0.016). No correlation was found between UtAD and studied protein levels in amniotic fluid. Mean MSsFlt-1 level was 305.2 ± 220.1 pg/ml and mean AFsFlt-1 was 48.9 ± 11.8 ng/ml. Mean MSsEng level was 4.5 ± 1.3 ng/ml, mean AFsEng level was found 0.7 ± 0.3 ng/ml. Mean values for UtAD were 1.3 ± 0.4, 0.6 ± 0.1 and 3.5 ± 1.3 for PI, RI, and S/D, respectively.
  
  
  CONCLUSIONS
  In normal second trimester pregnancies, there is a positive correlation between serum levels of sFlt-1 and sEng levels. Amniotic fluid levels of sEng and sFlt-1 are not correlated with UtAD in uncomplicated pregnancies.
authors.affiliation: a Department of Obstetrics and Gynecology , Adnan Menderes University Hospital , Aydin , Turkey.
authors.forename: Emre
authors.initials: E
authors.lastname: Zafer
authors.affiliation: a Department of Obstetrics and Gynecology , Adnan Menderes University Hospital , Aydin , Turkey.
authors.forename: Selda
authors.initials: S
authors.lastname: Demircan Sezer
authors.affiliation: a Department of Obstetrics and Gynecology , Adnan Menderes University Hospital , Aydin , Turkey.
authors.forename: Sumeyra
authors.initials: S
authors.lastname: Nergiz Avcioglu
authors.affiliation: a Department of Obstetrics and Gynecology , Adnan Menderes University Hospital , Aydin , Turkey.
authors.forename: Tolga
authors.initials: T
authors.lastname: Atakul
authors.affiliation: b Department of Biostatistics , Adnan Menderes University Faculty of Medicine , Aydin , Turkey.
authors.forename: Imran
authors.initials: I
authors.lastname: Kurt Omurlu
authors.affiliation: a Department of Obstetrics and Gynecology , Adnan Menderes University Hospital , Aydin , Turkey.
authors.forename: Hasan
authors.initials: H
authors.lastname: Yuksel
mesh_terms: D000328:Adult; D000653:Amniotic Fluid / Q000737:chemistry / Q000378:metabolism*; D020533:Angiogenesis Inhibitors / Q000097:blood* / Q000378:metabolism; D015415:Biomarkers / Q000032:analysis / Q000097:blood / Q000378:metabolism; D001774:Blood Chemical Analysis; D003430:Cross-Sectional Studies; D000071063:Endoglin / Q000032:analysis / Q000097:blood / Q000378:metabolism; D005260:Female; D005317:Fetal Growth Retardation / Q000175:diagnosis / Q000378:metabolism / Q000503:physiopathology; D006305:Health Status Indicators; D006801:Humans; D009035:Mothers; D011225:Pre-Eclampsia / Q000175:diagnosis / Q000378:metabolism / Q000503:physiopathology; D011247:Pregnancy; D011262:Pregnancy Trimester, Second / Q000378:metabolism / Q000502:physiology; D018615:Ultrasonography, Doppler, Color; D016216:Ultrasonography, Prenatal; D055988:Uterine Artery / Q000000981:diagnostic imaging* / Q000502:physiology; D040281:Vascular Endothelial Growth Factor Receptor-1 / Q000032:analysis / Q000097:blood / Q000378:metabolism; D055815:Young Adult
chemical_list: D020533:Angiogenesis Inhibitors; D015415:Biomarkers; C064206:ENG protein, human; D000071063:Endoglin; C501162:FLT1 protein, human; D040281:Vascular Endothelial Growth Factor Receptor-1
keywords: amniotic fluid sEng; amniotic fluid sFlt-1; sEng; sFlt-1; uterine artery Doppler