title: Outcomes of Acute Myocardial Infarction Patients Implanted With Biodegradable Polymer Biolimus-Eluting Stents Versus New-Generation Durable Polymer Drug-Eluting Stents: A Retrospective Analysis.
abstract: We compared outcomes between biodegradable polymer biolimus-eluting stent (BP-BES) and new-generation durable polymer drug-eluting stent (DP-DES) implantations in patients with acute myocardial infarction (MI). Among 13472 patients with acute MI in a nationwide registry, 557 (64.8%) were in the BP-BES and 303 (35.2%) in the new-generation DP-DES group following coronary reperfusion. The occurrence of major adverse cardiac events (MACE; death, MI, revascularization) and stent thrombosis was compared. Major adverse cardiac events occurred in 53 (6.2%) patients and showed similar rates between the BP-BES and new-generation DP-DES groups (all: 6.6% vs 5.9%, P = .652; propensity score [PS] matched: n = 380, 6.3% vs 5.3%, P = .623). Stent thrombosis did not differ between groups (all: 0.3% vs 0.4%, P = .892; PS matched: 0.5% vs 0.5%, P = 1.000). Major adverse cardiac event-free survival was comparable between groups (all: 93.4% vs 94.1%, log-rank P = .357; PS matched: 93.7% vs 94.7%, log-rank P = .445). Biodegradable polymer biolimus-eluting stent was not associated with MACE (all: hazard ratio [HR], 1.67; 95% confidence interval [CI], 0.75-3.74; P = 0.212; PS matched: HR, 1.05; 95% CI, 0.40-2.75; P = .915). In conclusion, in patients with acute MI, BP-BES was equivalent to the new-generation DP-DES in terms of outcomes.
authors.affiliation: 1 Department of Cardiology and Medical Research Institute, Pusan National University Hospital, Busan, South Korea.
authors.forename: Jeong Cheon
authors.initials: JC
authors.lastname: Choe
authors.affiliation: 1 Department of Cardiology and Medical Research Institute, Pusan National University Hospital, Busan, South Korea.
authors.forename: Kwang Soo
authors.initials: KS
authors.lastname: Cha
authors.affiliation: 1 Department of Cardiology and Medical Research Institute, Pusan National University Hospital, Busan, South Korea.
authors.forename: Hye Yoon
authors.initials: HY
authors.lastname: Jang
authors.affiliation: 1 Department of Cardiology and Medical Research Institute, Pusan National University Hospital, Busan, South Korea.
authors.forename: Jong Hyun
authors.initials: JH
authors.lastname: Choi
authors.affiliation: 1 Department of Cardiology and Medical Research Institute, Pusan National University Hospital, Busan, South Korea.
authors.forename: Bo Won
authors.initials: BW
authors.lastname: Kim
authors.affiliation: 1 Department of Cardiology and Medical Research Institute, Pusan National University Hospital, Busan, South Korea.
authors.forename: Jinhee
authors.initials: J
authors.lastname: Ahn
authors.affiliation: 1 Department of Cardiology and Medical Research Institute, Pusan National University Hospital, Busan, South Korea.
authors.forename: Jin Sup
authors.initials: JS
authors.lastname: Park
authors.affiliation: 1 Department of Cardiology and Medical Research Institute, Pusan National University Hospital, Busan, South Korea.
authors.forename: Hye Won
authors.initials: HW
authors.lastname: Lee
authors.affiliation: 1 Department of Cardiology and Medical Research Institute, Pusan National University Hospital, Busan, South Korea.
authors.forename: Jun-Hyok
authors.initials: JH
authors.lastname: Oh
authors.affiliation: 1 Department of Cardiology and Medical Research Institute, Pusan National University Hospital, Busan, South Korea.
authors.forename: Jung Hyun
authors.initials: JH
authors.lastname: Choi
authors.affiliation: 1 Department of Cardiology and Medical Research Institute, Pusan National University Hospital, Busan, South Korea.
authors.forename: Han Cheol
authors.initials: HC
authors.lastname: Lee
authors.affiliation: 1 Department of Cardiology and Medical Research Institute, Pusan National University Hospital, Busan, South Korea.
authors.forename: Taek Jong
authors.initials: TJ
authors.lastname: Hong
authors.affiliation: 2 Department of Cardiology, Chonnam National University Hospital, Gwangju, South Korea.
authors.forename: Youngkeun
authors.initials: Y
authors.lastname: Ahn
authors.affiliation: 2 Department of Cardiology, Chonnam National University Hospital, Gwangju, South Korea.
authors.forename: Myung Ho
authors.initials: MH
authors.lastname: Jeong
mesh_terms: D000368:Aged; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001672:Biocompatible Materials; D054855:Drug-Eluting Stents; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy*; D062645:Percutaneous Coronary Intervention; D011108:Polymers; D057216:Propensity Score; D012042:Registries; D056910:Republic of Korea; D012189:Retrospective Studies; D020123:Sirolimus / Q000031:analogs & derivatives* / Q000627:therapeutic use; D015996:Survival Rate; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D001672:Biocompatible Materials; D011108:Polymers; C518022:umirolimus; D020123:Sirolimus
keywords: acute myocardial infarction; biodegradable polymer biolimus-eluting stent; durable polymer drug-eluting stent; outcomes; stent thrombosis