title: Aza-bridged bisphenanthrolinyl Pt(II) complexes: Efficient stabilization and topological selectivity on telomeric G-quadruplexes.
abstract: Two platinum complexes with an aza-bridged bis(1,10-phenanthrolin-2-yl)amine (bpa) were synthesized. The two phenanthrolines in bpa entered a flat plane prior to binding of nucleic acids, which bestowed on the two Pt complexes a significantly high stabilizing ability on both DNA and RNA G-quadruplexes. Further extending alkyl tail from aromatic coordination core enabled the complexes to distinguish GQ sequence based upon the topological folding structures and enhanced the selectivity of the complex against duplex DNA. This study paved the way to develop Pt complexes as GQ stabilizers for specific folding topology and the applications to disease and/or personalized anticancer medicine/therapy.
authors.affiliation: Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 637371, Singapore.
authors.forename: Lei
authors.initials: L
authors.lastname: He
authors.affiliation: Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 637371, Singapore.
authors.forename: Zhenyu
authors.initials: Z
authors.lastname: Meng
authors.affiliation: Department of Breast Surgery, Shanghai Huangpu Center Hospital, Shanghai 200002, China.
authors.forename: Yi-Qun
authors.initials: YQ
authors.lastname: Xie
authors.affiliation: Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 637371, Singapore.
authors.forename: Xiang
authors.initials: X
authors.lastname: Chen
authors.affiliation: Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 637371, Singapore.
authors.forename: Tianhu
authors.initials: T
authors.lastname: Li
authors.affiliation: Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 637371, Singapore. Electronic address: fwshao@ntu.edu.sg.
authors.forename: Fangwei
authors.initials: F
authors.lastname: Shao
mesh_terms: D056831:Coordination Complexes / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D054856:G-Quadruplexes; D007555:Isoxazoles / Q000737:chemistry*; D009944:Organoplatinum Compounds / Q000737:chemistry*; D010984:Platinum / Q000737:chemistry*; D012313:RNA / Q000737:chemistry*
chemical_list: D056831:Coordination Complexes; D007555:Isoxazoles; D009944:Organoplatinum Compounds; C033962:anthranil; D010984:Platinum; D012313:RNA; D004247:DNA
keywords: Anti-cancer activity; Folding topology; G-quadruplex; Pt complex; RNA; Telomere