title: Maternal endothelial damage as a disorder shared by early preeclampsia, late preeclampsia and intrauterine growth restriction.
abstract: BACKGROUND
  Preeclampsia (PE) and intrauterine growth restriction (IUGR) are separate disease entities that have frequently been reported as sharing the same pathogenesis. In both of them, angiogenesis disorders and generalized endothelial damage with an accompanying inflammation are the dominant symptoms. In this study, we attempted to prove that both these processes demonstrate the same profile in early PE, late PE and IUGR patients, while the only difference is in the degree of exacerbation of the lesions.
  
  
  METHODS
  In 167 patients divided into four groups, three of those with early PE, late PE and IUGR and one control group, fms-like tyrosine kinase-1 (sFlt-1), placental growth factor (PlGF), high sensitive c-reactive protein (hsCRP) and fibronectin were determined. The behavior of these parameters in each of the groups was studied, and correlations between them were sought for.
  
  
  RESULTS
  Higher concentrations of sFlt-1, hsCRP and fibronectin and a lower concentration of PlGF were found in the study groups compared to the control group. Significant correlations were observed between the factors concerned.
  
  
  CONCLUSIONS
  The higher values of disordered angiogenesis markers, endothelial damage markers and inflammatory markers both in the PE and the intrauterine growth restriction (IUGR) groups suggest the existence of shared disorders in the development of these pathologies. The correlations between disordered angiogenesis markers and endothelial damage markers argue in favor of a mutual relationship between these two processes in the development of pathologies evolving as secondary to placental ischemia. The results obtained confirm that the lesion profiles are the same in both PE and IUGR patients, which can be utilized in developing common diagnostic criteria.
authors.affiliation: .
authors.forename: Sebastian
authors.initials: S
authors.lastname: Kwiatkowski
authors.affiliation: .
authors.forename: Barbara
authors.initials: B
authors.lastname: Dołegowska
authors.affiliation: .
authors.forename: Ewa
authors.initials: E
authors.lastname: Kwiatkowska
authors.affiliation: .
authors.forename: Rafał
authors.initials: R
authors.lastname: Rzepka
authors.affiliation: .
authors.forename: Natalia
authors.initials: N
authors.lastname: Marczuk
authors.affiliation: .
authors.forename: Beata
authors.initials: B
authors.lastname: Loj
authors.affiliation: .
authors.forename: Andrzej
authors.initials: A
authors.lastname: Torbè
mesh_terms: D000293:Adolescent; D000328:Adult; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D004730:Endothelium, Vascular / Q000503:physiopathology; D005260:Female; D005317:Fetal Growth Retardation / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D005353:Fibronectins / Q000097:blood*; D006801:Humans; D000072483:Placenta Growth Factor / Q000097:blood*; D011225:Pre-Eclampsia / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D011247:Pregnancy; D040281:Vascular Endothelial Growth Factor Receptor-1 / Q000097:blood*; D055815:Young Adult
chemical_list: D005353:Fibronectins; D000072483:Placenta Growth Factor; D002097:C-Reactive Protein; C501162:FLT1 protein, human; D040281:Vascular Endothelial Growth Factor Receptor-1
keywords: Fibronectin; IUGR; PlGF; preeclampsia; sFlt-1