title: Presentation and Management of Inguinal Lymphadenopathy in Ovarian Cancer.
abstract: The symptoms in ovarian cancer are often missed leading to dubious diagnosis and staging. Inguinal lymphadenopathy (ILAP) is reported to be rare and occurring via lymphatic or hematogenous route. The paucity of studies on ILAP in ovarian cancer indicates a scope of refining its staging and management. The present study aims to document the presentation and management of ILAP in ovarian cancer, which may also reflect its incidence and mechanism of spread. All patients of ovarian cancer with inguinal lymphadenopathy presenting to our institute from 1 January 2015 to 31 December 2015 were included. All clinical, treatment, and pathological details were analyzed. Seven patients of ovarian cancer presented with ILAP. The mean age and BMI were 53.29 +/- 8.38 years and 26.23 +/- 3.03 kg/m2. Presentation varied from advanced disease (adnexal, omental, peritoneal, and nodal) to isolated ILAP even without adnexal mass (n= 4). Mean CA 125 was 229.64 +/- 322 (20-924) and ovarian primary was confirmed on microscopy or immunohistochemistry. Six patients underwent surgery with (n= 4) or without neoadjuvant chemotherapy (n= 2). Complete cytoreduction could be achieved in all patients with acceptable operative and perioperative outcomes. Peritoneal surface spread, along hernia track to the groin, was seen in two patients. Histopathology showed advanced disease, isolated ILAP and no residual disease in 3, 2, and 1 patient, respectively. ILAP has diverse clinical presentation in ovarian cancers and is not that uncommon. ILAP may also occur by peritoneal surface spread and shows good results with cytoreductive surgery and chemotherapy.
authors.affiliation: Department of Surgical Oncology, Rajiv Gandhi Cancer Institute and Research Centre, Sector 5, Rohini, New Delhi 110085 India.
authors.forename: Shveta
authors.initials: S
authors.lastname: Giri
authors.affiliation: Department of Surgical Oncology, Rajiv Gandhi Cancer Institute and Research Centre, Sector 5, Rohini, New Delhi 110085 India.
authors.forename: Swati H
authors.initials: SH
authors.lastname: Shah
authors.affiliation: Department of Surgical Oncology, Rajiv Gandhi Cancer Institute and Research Centre, Sector 5, Rohini, New Delhi 110085 India.
authors.forename: Kanika
authors.initials: K
authors.lastname: Batra
authors.affiliation: Department of Surgical Oncology, Rajiv Gandhi Cancer Institute and Research Centre, Sector 5, Rohini, New Delhi 110085 India.
authors.lastname: Anu-Bajracharya
authors.affiliation: Department of Surgical Oncology, Rajiv Gandhi Cancer Institute and Research Centre, Sector 5, Rohini, New Delhi 110085 India.
authors.forename: Vandana
authors.initials: V
authors.lastname: Jain
authors.affiliation: Department of Surgical Oncology, Rajiv Gandhi Cancer Institute and Research Centre, Sector 5, Rohini, New Delhi 110085 India.
authors.forename: Himanshu
authors.initials: H
authors.lastname: Shukla
authors.affiliation: Department of Surgical Oncology, Rajiv Gandhi Cancer Institute and Research Centre, Sector 5, Rohini, New Delhi 110085 India.
authors.forename: Rupinder
authors.initials: R
authors.lastname: Sekhon
authors.affiliation: Department of Surgical Oncology, Rajiv Gandhi Cancer Institute and Research Centre, Sector 5, Rohini, New Delhi 110085 India.
authors.forename: Sudhir
authors.initials: S
authors.lastname: Rawal
keywords: Inguinal; Lymphadenopathy; Ovarian cancer