title: The Discovery of Tumor Angiogenesis Factors: A Historical Overview.
abstract: Starting with the hypothesis formulated by Judah Folkman that tumor growth is angiogenesis-dependent, this area of research has a solid scientific foundation, and inhibition of angiogenesis is a major area of therapeutic development for the treatment of cancer. This chapter offers an account of the most relevant discoveries in this field of biomedical research.
authors.affiliation: Department of Basic Medical Sciences, Neurosciences and Sensory Organs, University of Bari Medical School, Piazza Giulio Cesare, 11, 70124, Bari, Italy. domenico.ribatti@uniba.it.|National Cancer Institute "Giovanni Paolo II", Bari, Italy. domenico.ribatti@uniba.it.
authors.forename: Domenico
authors.initials: D
authors.lastname: Ribatti
mesh_terms: D020533:Angiogenesis Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D042501:Angiogenic Proteins / Q000378:metabolism*; D000818:Animals; D035843:Biomedical Research; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D049673:History, 20th Century; D006801:Humans; D008495:Medical Oncology / Q000266:history*; D009389:Neovascularization, Pathologic / Q000188:drug therapy / Q000378:metabolism*
chemical_list: D020533:Angiogenesis Inhibitors; D042501:Angiogenic Proteins
keywords: Angiogenesis; Anti-angiogenesis; History of medicine; Tumor growth