title: Caveolin-3 is aberrantly expressed in skeletal muscle cells in myasthenia gravis.
abstract: Caveolin-3 is a muscle-specific membrane protein that localizes to the sarcolemma and T-tubule system. Caveolin-3 is needed for muscle repair and skeletal muscle development. The objective of this study was to compare caveolin-3 expression in myasthenia gravis (MG) and control muscles. Caveolin-3 was abnormally expressed in the MG muscle membrane, with partial loss of expression and overexpression in 5/15 and 10/15 patients, respectively. Caveolin-3 mRNA and protein levels were higher in MG than in control muscles, suggesting that partial deficiency of caveolin-3 is occasionally detected in MG muscle and that caveolin-3 overexpression may be required after MG muscle damage.
authors.affiliation: Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science, 13-1 Takara-machi, Kanazawa 920-8640, Japan. Electronic address: neuiwasa@med.kanazawa-u.ac.jp.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Iwasa
authors.affiliation: Department of Neurology, National Hospital Organization Ishikawa Hospital, sa-150 Teduka-machi, Kaga 922-0405, Japan. Electronic address: furukawa@med.kanazawa-u.ac.jp.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Furukawa
authors.affiliation: Health Service Center, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan. Electronic address: hiroaki@staff.kanazawa-u.ac.jp.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Yoshikawa
authors.affiliation: Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science, 13-1 Takara-machi, Kanazawa 920-8640, Japan. Electronic address: m-yamada@med.kanazawa-u.ac.jp.
authors.forename: Masahito
authors.initials: M
authors.lastname: Yamada
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D051244:Caveolin 3 / Q000235:genetics / Q000378:metabolism*; D005260:Female; D015395:Histocompatibility Antigens Class I / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008285:Major Histocompatibility Complex; D008297:Male; D008875:Middle Aged; D018485:Muscle Fibers, Skeletal / Q000378:metabolism*; D018482:Muscle, Skeletal / Q000378:metabolism*; D009157:Myasthenia Gravis / Q000473:pathology*; D012333:RNA, Messenger / Q000378:metabolism; D055815:Young Adult
chemical_list: D051244:Caveolin 3; D015395:Histocompatibility Antigens Class I; D012333:RNA, Messenger
keywords: Caveolin-3; Myasthenia gravis; Skeletal muscle; qRT-PCR