title: Biparametric 3T Magnetic Resonance Imaging for prostatic cancer detection in a biopsy-naïve patient population: a further improvement of PI-RADS v2?
abstract: To prospectively determine the diagnostic accuracy of a biparametric 3T magnetic resonance imaging protocol (BP-MRI) for prostatic cancer detection, compared to a multiparametric MRI protocol (MP-MRI), in a biopsy naïve patient population.
  
  
  
  Eighty-two untreated patients (mean age 65±7.6years) with clinical suspicion of prostate cancer and/or altered prostate-specific antigen (PSA) levels underwent a MP-MRI, including T2-weighted imaging, diffusion-weighted imaging (with the correspondent apparent diffusion coefficient maps) and dynamic contrast enhanced sequence, followed by prostate biopsy. Two radiologists reviewed both the BP-MRI and the MP-MRI protocols to establish a radiological diagnosis. Receiver operating characteristics curves were obtained to determine the diagnostic performance of the two protocols.
  
  
  
  The mean PSA level was 8.8±8.1ng/ml. A total of 34 prostatic tumors were identified, with a Gleason score that ranged from 3+3 to 5+4. Of these 34 tumors, 29 were located within the peripheral zone and 5 in the transitional zone. BP-MRI and MP-MRI showed a similar performance in terms of overall diagnostic accuracy, with an area under the curve of 0.91 and 0.93, respectively (p=n.s.).
  
  
  
  BP-MRI prostate protocol is feasible for prostatic cancer detection compared to a standard MP-MRI protocol, requiring a shorter acquisition and interpretation time, with comparable diagnostic accuracy to the conventional protocol, without the administration of gadolinium-based contrast agent.
authors.affiliation: Department of Advanced Biomedical Sciences, University "Federico II", Naples, Italy.
authors.forename: Arnaldo
authors.initials: A
authors.lastname: Stanzione
authors.affiliation: Department of Advanced Biomedical Sciences, University "Federico II", Naples, Italy. Electronic address: mimbriaco@hotmail.com.
authors.forename: Massimo
authors.initials: M
authors.lastname: Imbriaco
authors.affiliation: Department of Advanced Biomedical Sciences, University "Federico II", Naples, Italy.
authors.forename: Sirio
authors.initials: S
authors.lastname: Cocozza
authors.affiliation: Department of Neurosciences, Reproductive Sciences and Odontostomatology, University "Federico II", Naples, Italy.
authors.forename: Ferdinando
authors.initials: F
authors.lastname: Fusco
authors.affiliation: Department of Advanced Biomedical Sciences, University "Federico II", Naples, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Rusconi
authors.affiliation: Department of Advanced Biomedical Sciences, University "Federico II", Naples, Italy.
authors.forename: Carmela
authors.initials: C
authors.lastname: Nappi
authors.affiliation: Department of Neurosciences, Reproductive Sciences and Odontostomatology, University "Federico II", Naples, Italy.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Mirone
authors.affiliation: Department of Neurosciences, Reproductive Sciences and Odontostomatology, University "Federico II", Naples, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Mangiapia
authors.affiliation: Department of Advanced Biomedical Sciences, University "Federico II", Naples, Italy.
authors.forename: Arturo
authors.initials: A
authors.lastname: Brunetti
authors.affiliation: Department of Radiology, Ospedale S. Maria delle Grazie, Pozzuoli, Italy.
authors.forename: Alfonso
authors.initials: A
authors.lastname: Ragozzino
authors.affiliation: Department of Neurosciences, Reproductive Sciences and Odontostomatology, University "Federico II", Naples, Italy.
authors.forename: Nicola
authors.initials: N
authors.lastname: Longo
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019540:Area Under Curve; D003287:Contrast Media; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods / Q000706:statistics & numerical data; D005240:Feasibility Studies; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007091:Image Processing, Computer-Assisted / Q000379:methods; D061705:Image-Guided Biopsy / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods* / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D011446:Prospective Studies; D017430:Prostate-Specific Antigen / Q000032:analysis; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging*; D012372:ROC Curve; D018084:Ultrasonography, Interventional / Q000379:methods
chemical_list: D003287:Contrast Media; D017430:Prostate-Specific Antigen
keywords: MRI; Medical oncology; PI-RADS; Prostate cancer; Urologic diseases