title: Plants Producing Ribosome-Inactivating Proteins in Traditional Medicine.
abstract: Ribosome-inactivating proteins (RIPs) are enzymes that deadenylate nucleic acids and are broadly distributed in the plant kingdom. Many plants that contain RIPs are listed in the pharmacopoeias of folk medicine all over the world, mostly because of their toxicity. This review analyses the position occupied in traditional medicine by plants from which RIPs have been isolated. The overview starts from the antique age of the Mediterranean area with ancient Egypt, followed by the Greek and Roman classic period. Then, the ancient oriental civilizations of China and India are evaluated. More recently, Unani medicine and European folk medicine are examined. Finally, the African and American folk medicines are taken into consideration. In conclusion, a list of RIP-expressing plants, which have been used in folk medicine, is provided with the geographical distribution and the prescriptions that are recommended by traditional healers. Some final considerations are provided on the present utilization of such herbal treatments, both in developing and developed countries, often in the absence of scientific validation. The most promising prospect for the medicinal use of RIP-expressing plants is the conjugation of purified RIPs to antibodies that recognise tumour antigens for cancer therapy.
authors.affiliation: Department of Experimental, Diagnostic and Specialty Medicine-DIMES, Alma Mater Studiorum, University of Bologna, Via San Giacomo 14, 40126 Bologna, Italy. letizia.polito@unibo.it.
authors.forename: Letizia
authors.initials: L
authors.lastname: Polito
authors.affiliation: Department of Experimental, Diagnostic and Specialty Medicine-DIMES, Alma Mater Studiorum, University of Bologna, Via San Giacomo 14, 40126 Bologna, Italy. massimo.bortolotti2@unibo.it.
authors.forename: Massimo
authors.initials: M
authors.lastname: Bortolotti
authors.affiliation: Department of Experimental, Diagnostic and Specialty Medicine-DIMES, Alma Mater Studiorum, University of Bologna, Via San Giacomo 14, 40126 Bologna, Italy. stefania.maiello2@unibo.it.
authors.forename: Stefania
authors.initials: S
authors.lastname: Maiello
authors.affiliation: Department of Experimental, Diagnostic and Specialty Medicine-DIMES, Alma Mater Studiorum, University of Bologna, Via San Giacomo 14, 40126 Bologna, Italy. mariagiulia.battelli@unibo.it.
authors.forename: Maria Giulia
authors.initials: MG
authors.lastname: Battelli
authors.affiliation: Department of Experimental, Diagnostic and Specialty Medicine-DIMES, Alma Mater Studiorum, University of Bologna, Via San Giacomo 14, 40126 Bologna, Italy. andrea.bolognesi@unibo.it.
authors.forename: Andrea
authors.initials: A
authors.lastname: Bolognesi
mesh_terms: D000818:Animals; D006801:Humans; D008516:Medicine, Chinese Traditional; D010602:Pharmacopoeias as Topic; D008517:Phytotherapy; D010940:Plant Proteins / Q000378:metabolism / Q000627:therapeutic use*; D010946:Plants, Medicinal / Q000737:chemistry* / Q000378:metabolism; D054788:Ribosome Inactivating Proteins / Q000378:metabolism / Q000627:therapeutic use*
chemical_list: D010940:Plant Proteins; D054788:Ribosome Inactivating Proteins
keywords: Ayurveda medicine; Unani medicine; ancient Egypt medicine; anticancer drugs; classic age medicine; ethnopharmacology; folk medicine; plant toxins; ribosome-inactivating proteins; traditional Chinese medicine