title: Patients' outcome after rescue plerixafor administration for autologous stem cell mobilization: a single-center retrospective analysis.
abstract: Plerixafor is predominantly used for patients mobilizing inadequate stem cell numbers for autologous transplantation after stimulation with granulocyte-colony-stimulating factor (G-CSF).
  
  
  
  We here report on 300 patients undergoing stem cell mobilization with G-CSF, among them 36 poor mobilizers (CD34+ cell counts < 50 × 106/L blood) receiving G-CSF alone and 49 receiving G-CSF in combination with plerixafor for rescue intervention. Mobilization efficacy and short-time outcome after autologous stem cell transplantation were analyzed and compared in the respective subgroups.
  
  
  
  Out of 49 patients treated with plerixafor and G-CSF, 46 (94%) collected sufficient hematopoietic stem cell numbers although the number was clearly inferior in poor mobilizers. Compared to good mobilizers, viability of CD34+ cells analyzed after collection was slightly reduced in poor mobilizers independent of the application of plerixafor. A total of 232 patients underwent autologous stem cell transplantation, among them 26 poor mobilizers who received only G-CSF and 31 patients who received G-CSF in combination with plerixafor. Time until neutrophil engraftment was in median 1 day later in poor mobilizers irrespective of the application of plerixafor. Platelet engraftment was in median 2 days delayed in patients mobilized with G-CSF and plerixafor compared to 1 day in poor mobilizers treated with G-CSF only. Frequency of detected CD38+ CD138+ CD45- CD56+ plasma cells in the apheresis products of myeloma patients was comparable for all groups.
  
  
  
  Our data demonstrate that plerixafor is highly effective as rescue measurement after mobilization failure with G-CSF alone and short-term clinical outcome after stem cell transplantation is comparable.
authors.affiliation: III. Medical Department, Hematology and Oncology, Klinikum rechts der Isar, Technische Universität München, München, Germany.
authors.forename: Silvia
authors.initials: S
authors.lastname: Spoerl
authors.affiliation: III. Medical Department, Hematology and Oncology, Klinikum rechts der Isar, Technische Universität München, München, Germany.
authors.forename: Robert
authors.initials: R
authors.lastname: Peter
authors.affiliation: III. Medical Department, Hematology and Oncology, Klinikum rechts der Isar, Technische Universität München, München, Germany.
authors.forename: Dagmar
authors.initials: D
authors.lastname: Wäscher
authors.affiliation: III. Medical Department, Hematology and Oncology, Klinikum rechts der Isar, Technische Universität München, München, Germany.
authors.forename: Katharina
authors.initials: K
authors.lastname: Götze
authors.affiliation: III. Medical Department, Hematology and Oncology, Klinikum rechts der Isar, Technische Universität München, München, Germany.
authors.forename: Mareike
authors.initials: M
authors.lastname: Verbeek
authors.affiliation: III. Medical Department, Hematology and Oncology, Klinikum rechts der Isar, Technische Universität München, München, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Peschel
authors.affiliation: III. Medical Department, Hematology and Oncology, Klinikum rechts der Isar, Technische Universität München, München, Germany.
authors.forename: Angela M
authors.initials: AM
authors.lastname: Krackhardt
mesh_terms: D064592:Autografts; D001596:Benzylamines; D001781:Blood Component Removal; D000080027:Cyclams; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage; D019650:Hematopoietic Stem Cell Mobilization / Q000379:methods*; D006571:Heterocyclic Compounds / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D009101:Multiple Myeloma / Q000097:blood / Q000628:therapy*; D036102:Peripheral Blood Stem Cell Transplantation; D000072916:Peripheral Blood Stem Cells; D010950:Plasma Cells / Q000378:metabolism; D012189:Retrospective Studies
chemical_list: D001596:Benzylamines; D000080027:Cyclams; D006571:Heterocyclic Compounds; D016179:Granulocyte Colony-Stimulating Factor; C088327:plerixafor