title: Pancreatic duct stenosis: Differential diagnosis between malignant and benign conditions at secretin-enhanced MRCP.
abstract: OBJECTIVE
  To define imaging criteria of benign and malignant nature in patients with main pancreatic duct (MPD) stenosis.
  
  
  METHODS
  S-MRCPs of 35 patients with pancreatitis and 14 with adenocarcinoma were evaluated.
  
  
  RESULTS
  Adenocarcinoma caused higher prevalence of complete stenosis (14/14-100% vs 17/35-49%), dilated side-branches (14/14-100% vs 18/35-51%) and lower prevalence of duct-penetrating sign (0/14-0% vs 31/35-89%). The number of stenoses was higher in benign conditions (mean 1.4 Vs 1). Upstream MPD diameter was higher in cancer-induced stenoses (4.5 vs 2.9mm).
  
  
  CONCLUSIONS
  Single complete stenosis with dilated side branches, increased MPD caliber and absent duct-penetrating sign are suggestive of malignancy.
authors.affiliation: Department of Radiology, Policlinico G.B. Rossi, University of Verona, Italy. Electronic address: boninsegnae@gmail.com.
authors.forename: Enrico
authors.initials: E
authors.lastname: Boninsegna
authors.affiliation: Department of Radiology, Policlinico G.B. Rossi, University of Verona, Italy.
authors.forename: Riccardo
authors.initials: R
authors.lastname: Manfredi
authors.affiliation: Department of Radiology, Policlinico G.B. Rossi, University of Verona, Italy.
authors.forename: Riccardo
authors.initials: R
authors.lastname: Negrelli
authors.affiliation: Department of Radiology, Policlinico G.B. Rossi, University of Verona, Italy.
authors.forename: Giacomo
authors.initials: G
authors.lastname: Avesani
authors.affiliation: Department of Radiology, Policlinico G.B. Rossi, University of Verona, Italy.
authors.forename: Sara
authors.initials: S
authors.lastname: Mehrabi
authors.affiliation: Department of Radiology, Policlinico G.B. Rossi, University of Verona, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Pozzi Mucelli
mesh_terms: D000328:Adult; D000368:Aged; D049448:Cholangiopancreatography, Magnetic Resonance / Q000379:methods*; D003251:Constriction, Pathologic / Q000000981:diagnostic imaging; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010183:Pancreatic Ducts / Q000000981:diagnostic imaging* / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012633:Secretin
chemical_list: D012633:Secretin
keywords: Cancer; MRCP; Magnetic resonance imaging; Pancreas; Pancreatic stenosis; Secretin