title: Meta-analysis of the association between asthma and serum levels of high-density lipoprotein cholesterol and low-density lipoprotein cholesterol.
abstract: The reported associations of blood lipid profiles with asthma are ambiguous.
  
  
  
  To explore the association between asthma and the serum levels of high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C).
  
  
  
  A systematic search was performed in the PubMed, MEDLINE, Cochrane Library, and Chinese Biomedical Literature databases. Ten studies were identified. We divided these studies into 2 subgroups according to age: children (<18 years old) and adults (≥18 years old).
  
  
  
  In children, the asthma group had lower HDL-C levels (weighted mean difference, -3.44; 95% confidence interval [CI], -5.83 to -1.04; P = .005) compared with the nonasthma group, whereas the serum levels of LDL-C in these 2 groups were not statistically different. In contrary, in adults, the asthma group had higher LDL-C levels (weighted mean difference, 8.95; 95% confidence interval, 3.55-14.35; P = .001) compared with the nonasthma group, whereas the HDL-C levels were not statistically different.
  
  
  
  There is a significant association between asthma and the serum levels of HDL-C and LDL-C. Moreover, this association differs in children and adults.
authors.affiliation: Department of Respiratory Medicine, Children's Hospital of Chongqing Medical University, Chongqing, China.
authors.forename: Jiayu
authors.initials: J
authors.lastname: Peng
authors.affiliation: Department of Respiratory Medicine, Children's Hospital of Chongqing Medical University, Chongqing, China. Electronic address: huangying126163@126.com.
authors.forename: Ying
authors.initials: Y
authors.lastname: Huang
mesh_terms: D000367:Age Factors; D001249:Asthma / Q000097:blood* / Q000209:etiology*; D016022:Case-Control Studies; D008076:Cholesterol, HDL / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL