title: Human gut microbiota: the links with dementia development.
abstract: Dementia is a comprehensive category of brain diseases that is great enough to affect a person's daily functioning. The most common type of dementia is Alzheimer's disease, which makes most of cases. New researches indicate that gastrointestinal tract microbiota are directly linked to dementia pathogenesis through triggering metabolic diseases and low-grade inflammation progress. A novel strategy is proposed for the management of these disorders and as an adjuvant for psychiatric treatment of dementia and other related diseases through modulation of the microbiota (e.g. with the use of probiotics).
authors.affiliation: Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China.
authors.forename: Rashad
authors.initials: R
authors.lastname: Alkasir
authors.affiliation: Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.affiliation: China-Japan Friendship Hospital, Beijing, 100029, China.
authors.forename: Xudong
authors.initials: X
authors.lastname: Li
authors.affiliation: China-Japan Friendship Hospital, Beijing, 100029, China.
authors.forename: Miao
authors.initials: M
authors.lastname: Jin
authors.affiliation: Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China. zhubaoli@im.ac.cn.|Collaborative Innovation Centre for Diagnosis and Treatment of Infectious Diseases, The First Attainted Hospital College of Medicine, Zhejiang University, Hangzhou, 310058, China. zhubaoli@im.ac.cn.
authors.forename: Baoli
authors.initials: B
authors.lastname: Zhu
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism / Q000382:microbiology / Q000503:physiopathology / Q000628:therapy; D000069196:Gastrointestinal Microbiome; D006801:Humans
keywords: alzheimer’s disease; dementia; gut microbiota; inflammation; probiotics