title: Protein Feeding in Pediatric Acute Kidney Injury Is Not Associated With a Delay in Renal Recovery.
abstract: Critically ill children with acute kidney injury (AKI) are at high risk of underfeeding. Newer guidelines for nutrition support recommend higher protein intake. Therefore, the study evaluated the effects of protein feeding on the resolution of AKI and compared energy and protein intake in patients with and without AKI after implementation of Nutrition Support guidelines.
  
  
  
  Retrospective study.
  
  
  
  Five hundred twenty critically ill children from October 2012 to June 2013 and October to December 2013.
  
  
  
  Energy and protein intake in patients with no AKI, resolved, or persistent AKI. Energy and protein intake was documented for days 1-8 of Pediatric Intensive Care Unit stay and in the postimplementation versus preimplementation period of nutrition support guidelines. AKI was defined by modified pRIFLE. Persistent AKI was defined as patients who did not resolve their AKI during the study period.
  
  
  
  A higher percentage of patients with resolved and persistent AKI met ≥ 80% of protein needs versus no AKI. After adjustment for Pediatric Risk of Mortality Score, the odds ratio for protein intake of ≥ 80% compared to <80% of estimated protein needs was not significant, which suggests that higher protein intake was not associated with nonresolution of AKI. There were significant improvements in the cumulative protein gap in patients with no AKI in the postimplementation (-1.0 [-1.7 to -0.6] g/kg/day) compared to preimplementation period (-1.3 [-1.7 to -0.9] g/kg/day, P = .001) and persistent AKI in the postimplementation (-0.8 [-1.4 to -0.1] g/kg/day) compared to preimplementation (-1.3 [-1.7 to -0.9] g/kg/day, P = .03).
  
  
  
  Higher protein intake was not associated with a delay in renal recovery in patients with AKI after adjustment for severity of illness. Protein intake was improved in critically ill children with no AKI, resolved, and persistent AKI after implementation of Nutrition Support Guidelines, but underfeeding persisted in these patients.
authors.affiliation: Section of Critical Care Medicine, Department of Pediatrics, Baylor College of Medicine/Texas Children's Hospital, Houston, Texas.
authors.forename: Ursula G
authors.initials: UG
authors.lastname: Kyle
authors.affiliation: Section of Critical Care Medicine, Department of Pediatrics, Baylor College of Medicine/Texas Children's Hospital, Houston, Texas; Section of Nephrology, Department of Pediatrics, Baylor College of Medicine/Texas Children's Hospital, Houston, Texas.
authors.forename: Ayse
authors.initials: A
authors.lastname: Akcan-Arikan
authors.affiliation: Section of Critical Care Medicine, Department of Pediatrics, Baylor College of Medicine/Texas Children's Hospital, Houston, Texas.
authors.forename: Jaime C
authors.initials: JC
authors.lastname: Silva
authors.affiliation: Section of Critical Care Medicine, Department of Pediatrics, Baylor College of Medicine/Texas Children's Hospital, Houston, Texas.
authors.forename: Michelle
authors.initials: M
authors.lastname: Goldsworthy
authors.affiliation: Section of Critical Care Medicine, Department of Pediatrics, Baylor College of Medicine/Texas Children's Hospital, Houston, Texas.
authors.forename: Lara S
authors.initials: LS
authors.lastname: Shekerdemian
authors.affiliation: Section of Critical Care Medicine, Department of Pediatrics, Baylor College of Medicine/Texas Children's Hospital, Houston, Texas. Electronic address: jorgec@bcm.edu.
authors.forename: Jorge A
authors.initials: JA
authors.lastname: Coss-Bu
mesh_terms: D058186:Acute Kidney Injury / Q000150:complications / Q000628:therapy*; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D016638:Critical Illness; D004044:Dietary Proteins / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007223:Infant; D015278:Intensive Care Units, Pediatric; D007668:Kidney / Q000503:physiopathology; D008297:Male; D044342:Malnutrition / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D018529:Nutritional Support / Q000379:methods*; D017410:Practice Guidelines as Topic; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D004044:Dietary Proteins