title: A New Path through the Nuclear Pore.
abstract: Knowing the configuration of the nuclear pore is essential for appreciating the underlying mechanisms of nucleo-cytoplasmic communication. Now, Fernandez-Martinez et al. present a high-resolution structure of the cytoplasmic nuclear pore-mRNA export holo-complex, challenging our textbook depiction of this massive membrane-embedded complex.
authors.affiliation: Department of Cell and Developmental Biology, Epigenetics Program, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Gozalo
authors.affiliation: Department of Cell and Developmental Biology, Epigenetics Program, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: capelson@mail.med.upenn.edu.
authors.forename: Maya
authors.initials: M
authors.lastname: Capelson
mesh_terms: D021581:Active Transport, Cell Nucleus; D003593:Cytoplasm / Q000378:metabolism; D022022:Nuclear Pore / Q000378:metabolism*; D028861:Nuclear Pore Complex Proteins / Q000737:chemistry; D009687:Nuclear Proteins / Q000235:genetics; D029543:Nucleocytoplasmic Transport Proteins / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism*
chemical_list: D028861:Nuclear Pore Complex Proteins; D009687:Nuclear Proteins; D029543:Nucleocytoplasmic Transport Proteins; D012333:RNA, Messenger