title: Diseases having an influence on inhibition of angiogenesis as risk factors of osteonecrosis of the jaw.
abstract: OBJECTIVE
  The objective of this study was to retrospectively investigate the association of diseases having an influence on inhibition of angiogenesis such as hypertension, diabetes mellitus type II, hypercholesterolemia, and rheumatoid arthritis (RA) with the development of osteonecrosis of the jaws.
  
  
  METHODS
  The 135 patients were allocated into 4 groups of bisphosphonate-related osteonecrosis of the jaw (BRONJ) group (1A); non-BRONJ group (1B); osteonecrosis of the jaw (ONJ) group (2A); and control group (2B), according to histologic results and use of bisphosphonate. This retrospective study was conducted with patients who were treated in one institute from 2012 to 2013. Fisher's exact test and logistic regression analysis were used to analyze the odds ratios of diseases having an influence on inhibition of angiogenesis for development of ONJ.
  
  
  RESULTS
  The effects of diabetes and hypertension were not statistically significant on development of ONJ. When not considering bisphosphonate use, RA exhibited a high odds ratio of 3.23 (P=0.094), while hyperlipidemia showed an odds ratio of 2.10 (P=0.144) for development of ONJ. More than one disease that had an influence on inhibition of angiogenesis showed a statistically significant odds ratio of 2.54 (P=0.012) for development of ONJ.
  
  
  CONCLUSIONS
  Patients without diseases having an influence on inhibition of angiogenesis were at less risk for developing ONJ.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Wonkwang University Dental Hospital, Wonkwang University, Iksan, Korea.
authors.forename: Seung Jae
authors.identifier: 0000-0002-5095-7543
authors.initials: SJ
authors.lastname: Paek
authors.affiliation: Department of Oral and Maxillofacial Surgery, College of Dentistry, Wonkwang University, Iksan, Korea.
authors.forename: Won-Jong
authors.identifier: 0000-0001-6687-5043
authors.initials: WJ
authors.lastname: Park
authors.affiliation: Department of Society Dentistry, College of Dentistry, Wonkwang University, Iksan, Korea.
authors.forename: Ho-Sung
authors.identifier: 0000-0002-9406-5870
authors.initials: HS
authors.lastname: Shin
authors.affiliation: Department of Oral and Maxillofacial Surgery, College of Dentistry, Wonkwang University, Iksan, Korea.
authors.forename: Moon-Gi
authors.identifier: 0000-0003-3502-7652
authors.initials: MG
authors.lastname: Choi
authors.affiliation: Department of Oral and Maxillofacial Surgery, College of Dentistry, Wonkwang University, Iksan, Korea.
authors.forename: Kyung-Hwan
authors.identifier: 0000-0002-5257-8440
authors.initials: KH
authors.lastname: Kwon
authors.affiliation: Department of Oral and Maxillofacial Surgery, College of Dentistry, Wonkwang University, Iksan, Korea.
authors.forename: Eun Joo
authors.identifier: 0000-0001-5377-8893
authors.initials: EJ
authors.lastname: Choi
keywords: Angiogenesis inhibitors; Bisphosphonate-associated osteonecrosis of the jaw; Hypercholesterolemia; Rheumatoid arthritis