title: MEG May Reveal Hidden Population of Spikes in Epilepsy With Porencephalic Cyst/Encephalomalacia.
abstract: Porencephalic cyst/encephalomalacia is often associated with intractable epilepsy. A limited number of studies reported magnetoencephalography's (MEG's) potential to help construct treatment strategy for epilepsies associated with porencephalic cyst/encephalomalacia. The authors present here simultaneous electroencephalography (EEG) and MEG findings in three adult patients with pediatric-onset epilepsy due to porencephalic cyst/encephalomalacia. There were two types of spikes: one type was detected by MEG only (EEG-/MEG+), and the other detected by both EEG and MEG (EEG+/MEG+). Both types were seen in all three cases. The EEG-/MEG+ spikes all formed tight clusters; in contrast, the majority of EEG+/MEG+ spikes formed loose clusters. These data suggest that MEG may be helpful to better identify spike populations in epilepsy patients with porencephalic cyst/encephalomalacia. If hidden spike populations were to be found by MEG, this information would affect the interpretation of patient's pathophysiology and planning of intracranial electrode placement.
authors.affiliation: *Epilepsy Center, Department of Neurology, Cleveland Clinic, Cleveland, Ohio, U.S.A.; and †Department of Epileptology, Tohoku University School of Medicine, Sendai, Japan.
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Kakisaka
authors.forename: Zhong I
authors.initials: ZI
authors.lastname: Wang
authors.forename: Sumiya
authors.initials: S
authors.lastname: Shibata
authors.forename: Yoko
authors.initials: Y
authors.lastname: Takahashi
authors.forename: John C
authors.initials: JC
authors.lastname: Mosher
authors.forename: Andreas V
authors.initials: AV
authors.lastname: Alexopoulos
authors.forename: Richard C
authors.initials: RC
authors.lastname: Burgess
mesh_terms: D001921:Brain / Q000503:physiopathology*; D004569:Electroencephalography; D004678:Encephalomalacia / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D004827:Epilepsy / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D005260:Female; D006801:Humans; D015225:Magnetoencephalography; D008297:Male; D008875:Middle Aged; D065708:Porencephaly / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D055815:Young Adult