title: Adult Acute Lymphoblastic Leukemia: A Genetic Overview and Application to Clinical Practice.
abstract: BACKGROUND
  Cytogenetic and molecular features of diseases, such as B-cell precursor acute lymphoblastic leukemia (BCP-ALL), are increasingly used for diagnostic, prognostic, and treatment decisions in health care.
  
  
  OBJECTIVE
  This review provides information on the current recommendations for evaluating genetic aberrations in patients with BCP-ALL and details how the results are incorporated to determine risk stratification. It also offers a brief overview of developing research on newly found genetic features that may play a role in prognostic and treatment decisions.
  
  
  METHODS
  Databases were reviewed using search terms relevant to BCP-ALL genetics, as well as to the prognostic significance of genetic changes commonly seen in BCP-ALL. Because of the scope of this review, studies identified as having outcomes with implications for clinical practice were included.
  
  
  RESULTS
  Cytogenetic and molecular aberrations in BCP-ALL are important not only for risk stratification but also for treatment decisions. To provide efficient and effective care for patients with BCP-ALL, clinical practitioners need to be aware of current recommendations and the state of prevailing research.
authors.affiliation: Augusta University Georgia Cancer Center.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Jacobson
authors.affiliation: Clemson University.
authors.forename: Matthew
authors.initials: M
authors.lastname: Tedder
authors.affiliation: Clemson University.
authors.forename: Julie
authors.initials: J
authors.lastname: Eggert
mesh_terms: D000328:Adult; D000367:Age Factors; D018572:Disease-Free Survival; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology*; D055106:Genome-Wide Association Study; D006801:Humans; D015994:Incidence; D008297:Male; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics* / Q000401:mortality / Q000628:therapy*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000453:epidemiology / Q000235:genetics* / Q000628:therapy*; D011379:Prognosis; D018570:Risk Assessment; D012720:Severity of Illness Index; D012737:Sex Factors; D016019:Survival Analysis
keywords: B-cell precursor acute lymphoblastic leukemia; cytogenetics of ALL; genetics; risk stratification of ALL