title: Phenotypes and Pathology of Drug-Induced Liver Disease.
abstract: Drug hepatotoxicity can simulate nearly any clinical syndrome or pathologic lesion that may occur in the liver, so clinical and histopathologic diagnosis of drug-induced liver injury may be difficult. Nevertheless, most drugs that are known to idiosyncratic liver injury tend to cause patterns of injury that produce characteristic phenotypes. Recognition of these patterns or phenotypes in liver biopsy material is helpful in evaluation of clinical cases of suspected drug-induced liver injury.
authors.affiliation: Liver Pathology Research and Consultation, Center for Liver Diseases, Inova Fairfax Hospital, 3300 Gallows Road, Falls Church, VA 22042, USA. Electronic address: zachary.goodman@inova.org.
authors.forename: Zachary D
authors.initials: ZD
authors.lastname: Goodman
mesh_terms: D001707:Biopsy, Needle; D056486:Chemical and Drug Induced Liver Injury / Q000235:genetics* / Q000473:pathology*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D010641:Phenotype; D011237:Predictive Value of Tests
chemical_list: D004364:Pharmaceutical Preparations
keywords: Drug-induced liver injury; Hepatotoxicity; Histopathology; Liver biopsy