title: Iron Deficiency Is a Determinant of Functional Capacity and Health-related Quality of Life 30 Days After an Acute Coronary Syndrome.
abstract: OBJECTIVE
  Iron deficiency (ID) is a prevalent condition in patients with ischemic heart disease and heart failure. Little is known about the impact of ID on exercise capacity and quality of life (QoL) in the recovery phase after an acute coronary syndrome (ACS).
  
  
  METHODS
  Iron status and its impact on exercise capacity and QoL were prospectively evaluated in 244 patients 30 days after the ACS. QoL was assessed by the standard EuroQoL-5 dimensions, EuroQoL visual analogue scale, and Heart-QoL questionnaires. Exercise capacity was analyzed by treadmill/6-minute walk tests. The effect of ID on cardiovascular mortality and readmission rate was also investigated.
  
  
  RESULTS
  A total of 46% of the patients had ID. These patients had lower exercise times (366±162 vs 462±155seconds; P<.001), metabolic consumption rates (7.9±2.9 vs 9.3±2.6 METS; P=.003), and EuroQoL-5 dimensions (0.76±0.25 vs 0.84±0.16), visual analogue scale (66±16 vs 72±17), and Heart-QoL (1.9±0.6 vs 2.2±0.6) scores (P<.05). ID independently predicted lower exercise times (OR, 2.9; 95%CI, 1.1-7.6; P=.023) and worse QoL (OR, 1.9; 95%CI, 1.1-3.3; P<.001) but had no effect on cardiovascular morbidity or mortality.
  
  
  CONCLUSIONS
  ID, a prevalent condition in ACS patients, results in a poorer mid-term functional recovery, as measured by exercise capacity and QoL.
authors.affiliation: Departamento de Cardiología, Hospital del Mar, Grupo de Investigación Biomédica en Enfermedades del Corazón, IMIM (Instituto Hospital del Mar de Investigaciones Médicas), Universitat Autònoma de Barcelona, Barcelona, Spain. Electronic address: 98605@parcdesalutmar.cat.
authors.forename: Oona
authors.initials: O
authors.lastname: Meroño
authors.affiliation: Departamento de Cardiología, Hospital del Mar, Grupo de Investigación Biomédica en Enfermedades del Corazón, IMIM (Instituto Hospital del Mar de Investigaciones Médicas), Universitat Autònoma de Barcelona, Barcelona, Spain.
authors.forename: Mercè
authors.initials: M
authors.lastname: Cladellas
authors.affiliation: Departamento de Cardiología, Hospital del Mar, Grupo de Investigación Biomédica en Enfermedades del Corazón, IMIM (Instituto Hospital del Mar de Investigaciones Médicas), Universitat Autònoma de Barcelona, Barcelona, Spain.
authors.forename: Núria
authors.initials: N
authors.lastname: Ribas-Barquet
authors.affiliation: Departamento de Cardiología, Hospital del Mar, Barcelona, Spain.
authors.forename: Paula
authors.initials: P
authors.lastname: Poveda
authors.affiliation: Departamento de Cardiología, Hospital del Mar, Grupo de Investigación Biomédica en Enfermedades del Corazón, IMIM (Instituto Hospital del Mar de Investigaciones Médicas), Universitat Autònoma de Barcelona, Barcelona, Spain.
authors.forename: Lluis
authors.initials: L
authors.lastname: Recasens
authors.affiliation: Departamento de Cardiología, Hospital del Mar, Barcelona, Spain.
authors.forename: Víctor
authors.initials: V
authors.lastname: Bazán
authors.affiliation: Departamento de Cardiología, Hospital del Mar, Barcelona, Spain.
authors.forename: Cosme
authors.initials: C
authors.lastname: García-García
authors.affiliation: Departamento de Cardiología, Hospital del Mar, Grupo de Investigación Biomédica en Enfermedades del Corazón, IMIM (Instituto Hospital del Mar de Investigaciones Médicas), Universitat Autònoma de Barcelona, Barcelona, Spain.
authors.forename: Consol
authors.initials: C
authors.lastname: Ivern
authors.affiliation: Departamento de Cardiología, Hospital del Mar, Grupo de Investigación Biomédica en Enfermedades del Corazón, IMIM (Instituto Hospital del Mar de Investigaciones Médicas), Universitat Autònoma de Barcelona, Barcelona, Spain.
authors.forename: Cristina
authors.initials: C
authors.lastname: Enjuanes
authors.affiliation: Laboratorio de Referencia de Catalunya, El Prat de Llobregat, Barcelona, Spain.
authors.forename: Salvador
authors.initials: S
authors.lastname: Orient
authors.affiliation: Grupo de Investigación en Genética y Epidemiología Cardiovascular, Programa de Investigación en Procesos Inflamatorios y Cardiovasculares, IMIM (Instituto Hospital del Mar de Investigaciones Médicas)-Hospital del Mar, Barcelona, Spain.
authors.forename: Joan
authors.initials: J
authors.lastname: Vila
authors.affiliation: Departamento de Cardiología, Hospital del Mar, Grupo de Investigación Biomédica en Enfermedades del Corazón, IMIM (Instituto Hospital del Mar de Investigaciones Médicas), Universitat Autònoma de Barcelona, Barcelona, Spain.
authors.forename: Josep
authors.initials: J
authors.lastname: Comín-Colet
mesh_terms: D054058:Acute Coronary Syndrome / Q000150:complications* / Q000401:mortality / Q000503:physiopathology*; D000368:Aged; D000369:Aged, 80 and over; D017079:Exercise Tolerance; D005260:Female; D006801:Humans; D000090463:Iron Deficiencies; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011788:Quality of Life; D020127:Recovery of Function; D013997:Time Factors
keywords: Acute coronary syndrome; Calidad de vida; Capacidad de esfuerzo; Capacidad funcional; Déficit de hierro; Exercise capacity; Functional capacity; Inflamación; Inflammation; Iron deficiency; Quality of life; Síndrome coronario agudo