title: A new method for evaluation of the autonomic nervous system in patients with idiopathic hyperhidrosis: systolic blood pressure and heart rate recovery after graded exercise.
abstract: BACKGROUND
  Idiopathic hyperhidrosis (IH) is characterized by excessive and uncontrolled production of sweat, mainly localized to the soles, palms, axillae and craniofacial area. Although IH is a disease concerning the autonomic nervous system, it is not clear yet whether this dysfunction is local or systemic.
  
  
  OBJECTIVE
  To evaluate the autonomic control of cardiovascular system by measuring values of heart rate recovery (HRR) and systolic blood pressure recovery (SBPR) obtained at various time intervals after maximal graded exercise treadmill testing in patients with IH compared with controls.
  
  
  METHODS
  The study population comprised 36 patients with IH (20 men, 16 women; mean age 25 ± 7 years) and 36 healthy controls (HCs) (12 men, 24 women; mean age 27 ± 5 years). All patients were selected from young, nonobese and healthy sedentary individuals.
  
  
  RESULTS
  Peak HR values reached in patients with IH were significantly higher compared with the HC group (P < 0.001). The obtained HRR values at minutes 3, 4 and 5 were significantly lower in the IH than the HC group [57 ± 16 vs. 64 ± 9 (P = 0.03); 61 ± 14 vs. 68 ± 9 (P = 0.03); 64 ± 12 vs. 70 ± 7 (P < 0.01)]. In addition, calculated mean values for SBPR1 and SBPR2 were > 1 in patients with IH (1.04 ± 0.15 vs. 0.98 ± 0.08 and 1.0 ± 0.12 vs. 0.94 ± 0.06, respectively) and these were statistically significant compared with the HC group (P = 0.04 and P = 0.03, respectively).
  
  
  CONCLUSIONS
  The significantly impaired SBPR and decreased HRR values we observed in patients with IH may indicate that the autonomic dysfunction in IH is a systemic disorder with cardiovascular effects, rather than a merely local disease. Both HRR and SBPR values may provide additional information about predicting adverse cardiovascular events in the future even in apparently healthy young patients with IH.
authors.affiliation: Department of Cardiology, Medical Faculty, Pamukkale University, Denizli, Turkey.
authors.forename: Y I
authors.initials: YI
authors.lastname: Alihanoglu
authors.affiliation: Department of Cardiology, Medical Faculty, Pamukkale University, Denizli, Turkey.
authors.forename: B S
authors.initials: BS
authors.lastname: Yildiz
authors.affiliation: Department of Cardiology, Medical Faculty, Pamukkale University, Denizli, Turkey.
authors.forename: I D
authors.initials: ID
authors.lastname: Kilic
authors.affiliation: Department of Cardiology, Medical Faculty, Pamukkale University, Denizli, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Saricopur
authors.affiliation: Department of Dermatology, Medical Faculty, Pamukkale University, Denizli, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Oncu
authors.affiliation: Department of Cardiology, Medical Faculty, Pamukkale University, Denizli, Turkey.
authors.forename: I
authors.initials: I
authors.lastname: Buber
authors.affiliation: Department of Dermatology, Medical Faculty, Pamukkale University, Denizli, Turkey.
authors.forename: L
authors.initials: L
authors.lastname: Tasli
authors.affiliation: Department of Cardiology, Medical Faculty, Pamukkale University, Denizli, Turkey.
authors.forename: H
authors.initials: H
authors.lastname: Evrengul
mesh_terms: D000293:Adolescent; D000328:Adult; D001341:Autonomic Nervous System / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology*; D016022:Case-Control Studies; D015444:Exercise / Q000502:physiology; D005080:Exercise Test / Q000379:methods*; D005260:Female; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D006945:Hyperhidrosis / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D055815:Young Adult