title: How and Why Study Posttraumatic Epileptogenesis in Animal Models?
abstract: Traumatic brain injury (TBI) greatly increases the risk of medically intractable epilepsy. Several models of TBI have been developed to investigate the relationship between TBI and posttraumatic epileptogenesis. Because the incident that precipitates development of epilepsy is known, studying mechanisms of epileptogenesis, identifying biomarkers to predict PTE, and developing treatments to prevent epilepsy after TBI are attainable research goals.
authors.affiliation: Department of Physiology, Spinal Cord and Brain Injury Research Center, and Epilepsy Center, University of Kentucky, Lexington, KY.
authors.forename: Bret N
authors.initials: BN
authors.lastname: Smith