title: 3D bioengineered tissues: From advancements in in vitro safety to new horizons in disease modeling.
abstract: Research aimed at more fully emulating human biology in vitro has rapidly progressed in recent years with advancements in 3D tissue engineering and microphysiological systems. The initial target of such systems has been directed towards drug and chemical safety assessment, with the goal of improving sensitivity and predictive capabilities. Here we discuss recent developments of in vitro organ culture systems, and their future applications in modeling human disease.
authors.affiliation: Organovo Holdings Inc, San Diego, California, USA.
authors.forename: R N
authors.initials: RN
authors.lastname: Hardwick
authors.affiliation: Organovo Holdings Inc, San Diego, California, USA.
authors.forename: C
authors.initials: C
authors.lastname: Viergever
authors.affiliation: Organovo Holdings Inc, San Diego, California, USA.
authors.forename: A E
authors.initials: AE
authors.lastname: Chen
authors.affiliation: Organovo Holdings Inc, San Diego, California, USA.
authors.forename: D G
authors.initials: DG
authors.lastname: Nguyen
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D021621:Imaging, Three-Dimensional; D010829:Physiological Phenomena; D023822:Tissue Engineering / Q000639:trends*