title: Preoperative neutrophil-to-lymphocyte ratio and plateletto- lymphocyte ratio as new prognostic factors for patients with colorectal cancer.
abstract: OBJECTIVE
  The objective of this study was to preoperatively evaluate blood platelet to lymphocyte ratio (PLR) and neutrophil to lymphocyte ratio (NLR) for their prognostic value in patients with colorectal cancer (CRC).
  
  
  METHODS
  We retrospectively reviewed 347 patients who underwent colorectal surgery for CRC in the Istanbul Education and Research Hospital and the Antalya Education and Research Hospital. The prognostic value of preoperative PLR, NLR, and other clinical and laboratory parameters was assessed with univariate and multivariate analysis.
  
  
  RESULTS
  Median overall survival (OS) was 61.8 months [95% CI for hazard ratio (HR) 46.24-77.14]. Significant parameters in univariate analysis, which were the preoperative levels of carcinoembryonic antigen (CEA) (p=0.055), albumin (p=0.003), hemoglobin (p=0.012), PLR (p=0.004), and NLR (p=0.054) were assessed by multivariate analysis which showed that only albumin retained its significance (p=0.008). Median OS was 70.1 vs 44.8 months with PLR ? 180 vs PLR > 180 (log rank; p=0.005). Median OS was "Not reached" (NR) vs 43.5 months with NLR ? 3 vs NLR > 3 (log rank; p=0.012).
  
  
  CONCLUSIONS
  This study showed that preoperative levels of CEA, albumin, PLR, and NLR have significant prognostic value for patients with CRC.
authors.affiliation: Istanbul Education and Research Hospital, Department of General Surgery, Istanbul, Turkey.
authors.forename: Mert
authors.initials: M
authors.lastname: Mahsuni Sevinc
authors.forename: Umut
authors.initials: U
authors.lastname: Riza Gunduz
authors.forename: Erdem
authors.initials: E
authors.lastname: Kinaci
authors.forename: Asim
authors.initials: A
authors.lastname: Armagan Aydin
authors.forename: Savas
authors.initials: S
authors.lastname: Bayrak
authors.forename: Riza
authors.initials: R
authors.lastname: Umar Gursu
authors.forename: Seyda
authors.initials: S
authors.lastname: Gunduz
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood; D001792:Blood Platelets; D002272:Carcinoembryonic Antigen / Q000097:blood; D015179:Colorectal Neoplasms / Q000097:blood* / Q000401:mortality / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D018655:Lymphocyte Count; D008214:Lymphocytes; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009504:Neutrophils; D010976:Platelet Count; D011237:Predictive Value of Tests; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012307:Risk Factors; D012709:Serum Albumin / Q000032:analysis; D000075462:Serum Albumin, Human; D013997:Time Factors; D014421:Turkey
chemical_list: C422455:ALB protein, human; D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D012709:Serum Albumin; D000075462:Serum Albumin, Human