title: Importance of Both Early Reperfusion and Therapeutic Hypothermia in Limiting Myocardial Infarct Size Post-Cardiac Arrest in a Porcine Model.
abstract: The aim of this study was to test the hypothesis that hypothermia and early reperfusion are synergistic for limiting infarct size when an acutely occluded coronary is associated with cardiac arrest.
  
  
  
  Cohort studies have shown that 1 in 4 post-cardiac arrest patients without ST-segment elevation has an acutely occluded coronary artery. However, many interventional cardiologists remain unconvinced that immediate coronary angiography is needed in these patients.
  
  
  
  Thirty-two swine (mean weight 35 ± 5 kg) were randomly assigned to 1 of the following 4 treatment groups: group A, hypothermia and reperfusion; group B, hypothermia and no reperfusion; group C, no hypothermia and reperfusion; and group D, no hypothermia and no reperfusion. The left anterior descending coronary artery was occluded with an intracoronary balloon, and ventricular fibrillation was electrically induced. Cardiopulmonary resuscitation was begun after 4 min of cardiac arrest. Defibrillation was attempted after 2 min of cardiopulmonary resuscitation. Resuscitated animals randomized to hypothermia were rapidly cooled to 34°C, whereas those randomized to reperfusion had such after 45 min of left anterior descending coronary artery occlusion.
  
  
  
  At 4 h, myocardial infarct size was calculated. Group A had the smallest infarct size at 16.1 ± 19.6% (p < 0.05). Group C had an intermediate infarct size at 29.5 ± 20.2%, whereas groups B and D had the largest infarct sizes at 41.5 ± 15.5% and 41.1 ± 15.0%, respectively.
  
  
  
  Acute coronary occlusion is often associated with cardiac arrest, so treatment of resuscitated patients should include early coronary angiography for potential emergent reperfusion, while providing hypothermia for both brain and myocardial protection. Providing only early hypothermia, while delaying coronary angiography, is not optimal.
authors.affiliation: University of Arizona Sarver Heart Center, Tucson, Arizona. Electronic address: kernk@email.arizona.edu.
authors.forename: Karl B
authors.initials: KB
authors.lastname: Kern
authors.affiliation: University of Arizona Sarver Heart Center, Tucson, Arizona.
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Hanna
authors.affiliation: University of Arizona Sarver Heart Center, Tucson, Arizona.
authors.forename: Hayley N
authors.initials: HN
authors.lastname: Young
authors.affiliation: University of Arizona Sarver Heart Center, Tucson, Arizona.
authors.forename: Carl J
authors.initials: CJ
authors.lastname: Ellingson
authors.affiliation: University of Arizona Sarver Heart Center, Tucson, Arizona.
authors.forename: Joshua J
authors.initials: JJ
authors.lastname: White
authors.affiliation: University of Arizona Sarver Heart Center, Tucson, Arizona.
authors.forename: Brian
authors.initials: B
authors.lastname: Heller
authors.affiliation: Zoll Circulation, San Jose, California.
authors.forename: Uday
authors.initials: U
authors.lastname: Illindala
authors.affiliation: University of Arizona Sarver Heart Center, Tucson, Arizona.
authors.forename: Chiu-Hsieh
authors.initials: CH
authors.lastname: Hsu
authors.affiliation: University of Arizona Sarver Heart Center, Tucson, Arizona; University of Basel, Basel, Switzerland.
authors.forename: Mathias
authors.initials: M
authors.lastname: Zuercher
mesh_terms: D000818:Animals; D016887:Cardiopulmonary Resuscitation; D003131:Combined Modality Therapy; D054059:Coronary Occlusion / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D004195:Disease Models, Animal; D006323:Heart Arrest / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D007036:Hypothermia, Induced / Q000009:adverse effects; D009203:Myocardial Infarction / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D015425:Myocardial Reperfusion / Q000009:adverse effects; D009206:Myocardium / Q000473:pathology*; D034421:Sus scrofa; D013997:Time Factors; D061665:Time-to-Treatment; D014693:Ventricular Fibrillation / Q000503:physiopathology / Q000628:therapy
keywords: cardiac arrest; coronary angiography; hypothermia; myocardial infarction; reperfusion; resuscitation