title: Histopathologic Diagnosis of Atypical Primary Vitreoretinal Lymphoma following Enucleation.
abstract: BACKGROUND
  Primary vitreoretinal lymphoma (PVRL) is a rare but potentially fatal malignancy. The diagnosis of PVRL remains challenging. Here, we present a case of PVRL with a diagnostic enucleation required to establish the diagnosis.
  A 58-year-old otherwise healthy woman was referred for evaluation of panuveitis with persistent blurred vision in the left eye. Extensive laboratory work-up was negative. On initial evaluation, the patient had visual acuity of no light perception in the left eye. Examination of the left eye revealed diffuse neovascularization of the iris, moderate vitreous debris and no view of the posterior pole. A B-scan ultrasound showed a retinal detachment and extensive subretinal fluid. Enucleation was performed.
  
  
  RESULTS
  On gross examination, a white mass was noted under the RPE. Histologic examination showed a mass of large CD20+ lymphocytes under the RPE.
  
  
  CONCLUSIONS
  The histopathologic findings confirmed a diagnosis of large B-cell lymphoma (PVRL).
  
  
  CONCLUSIONS
  PVRL may masquerade as uveitis, thus leading to a delay in diagnosis and management. A diagnostic enucleation may be useful in blind painful eyes of unknown etiology.
authors.affiliation: Department of Ophthalmology, Emory University, Ga., USA; Department of Emory Eye Center, Atlanta, Ga., USA.
authors.forename: Arjun B
authors.initials: AB
authors.lastname: Sood
authors.affiliation: Department of Ophthalmology, Emory University, Ga., USA; Department of Emory Eye Center, Atlanta, Ga., USA.
authors.forename: Steven
authors.initials: S
authors.lastname: Yeh
authors.affiliation: Department of Ophthalmology, Emory University, Ga., USA; Department of Pathology, Emory University, Ga., USA; Department of Emory Eye Center, Atlanta, Ga., USA.
authors.forename: Pia
authors.initials: P
authors.lastname: Mendoza
authors.affiliation: Department of Ophthalmology, Emory University, Ga., USA; Department of Emory Eye Center, Atlanta, Ga., USA.
authors.forename: Hans E
authors.initials: HE
authors.lastname: Grossniklaus
keywords: Histopathology; Primary vitreoretinal lymphoma