title: Association between pulmonary fibrosis and osteoporosis in the elderly people: A case-control study.
abstract: In this case-control study, we evaluated the association between osteoporosis and pulmonary fibrosis in the elderly. Participants were divided into a test group and a control group depending on bone mineral density and grid pattern changes of pulmonary fibrosis. We measured general conditions, related risk factors, serum biochemical index, grid pattern changes of double lungs, pulmonary function, arterial oxygen pressure (PO2), and bone mineral density of participates, and investigated the data through statistical analysis on SPSS 17.0 (SPSS Inc, Chicago, Illinois, USA). Significant differences were observed between groups in all collected indices except PO4. The ratio of pulmonary function disorder was higher in the test group versus the control group (12.0% vs 4.3%). Logistic regression shows that pulmonary fibrosis is a risk factor of osteoporosis, independent of age, sex, body mass index, smoking status, diabetes mellitus, alkaline phosphatase, glycosylated hemoglobin, Ca, PO4, tumor necrosis factor-α, vitamin D total, ventilation disorder, diffusive dysfunction, and hypoxemia. Senile osteoporosis is closely associated with pulmonary fibrosis, diabetes mellitus, smoking, sexuality, age, and body mass index. Pulmonary fibrosis modestly affects the incidence of osteoporosis and thus is a more promising predictor of osteoporosis.
authors.affiliation: Department of Spine Surgery, the First Affiliated Hospital of University of South China, Heangyang, Hunan Province Center of bone trauma diagnostic and treatment, Henan Province Hospital of Traditional Chinese Medicine, Zhengzhou, Henan Province Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
authors.forename: Zhong
authors.initials: Z
authors.lastname: Xie
authors.forename: Yanhong
authors.initials: Y
authors.lastname: He
authors.forename: Yongqiang
authors.initials: Y
authors.lastname: Sun
authors.forename: Zhanzhan
authors.initials: Z
authors.lastname: Lin
authors.forename: Mingzhi
authors.initials: M
authors.lastname: Yang
authors.forename: Qian
authors.initials: Q
authors.lastname: Liu
authors.forename: Sihai
authors.initials: S
authors.lastname: Liu
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D010024:Osteoporosis / Q000150:complications* / Q000453:epidemiology; D011658:Pulmonary Fibrosis / Q000150:complications*; D012307:Risk Factors