title: Sensory-motor axonal polyneuropathy involving cranial nerves: An uncommon manifestation of disulfiram toxicity.
abstract: Disulfiram (tetraethylthiuram disulfide) has been used for the treatment of alcohol dependence. An axonal sensory-motor polyneuropathy with involvement of cranial pairs due to disulfiram is exceedingly rare. The authors report a unique case of an extremely severe axonal polyneuropathy involving cranial nerves that developed within weeks after a regular dosage of 500mg/day disulfiram. To the authors best knowledge, such a severe and rapidly-progressive course has never been described with disulfiram dosages of only 500mg/day.
authors.affiliation: Neurology Department, Centro Hospitalar Vila Nova de Gaia/Espinho, Porto, Portugal. Electronic address: telma.cristiana.santos@gmail.com.
authors.forename: Telma
authors.initials: T
authors.lastname: Santos
authors.affiliation: Neurology Department, Centro Hospitalar Vila Nova de Gaia/Espinho, Porto, Portugal.
authors.forename: António
authors.initials: A
authors.lastname: Martins Campos
authors.affiliation: Neurology Department, Centro Hospitalar Vila Nova de Gaia/Espinho, Porto, Portugal.
authors.forename: Hugo
authors.initials: H
authors.lastname: Morais
mesh_terms: D000328:Adult; D000427:Alcohol Deterrents / Q000008:administration & dosage / Q000633:toxicity*; D000437:Alcoholism / Q000188:drug therapy*; D003391:Cranial Nerves / Q000187:drug effects*; D004221:Disulfiram / Q000008:administration & dosage / Q000633:toxicity*; D006801:Humans; D008297:Male; D011115:Polyneuropathies / Q000139:chemically induced*
chemical_list: D000427:Alcohol Deterrents; D004221:Disulfiram
keywords: Alcohol; Disulfiram; Neuropathy