title: [Preoperative therapy switch before glaucoma filtration surgery : Influence of the systemic antiglaucomatous and local antiphlogistic therapy on the intraocular pressure].
abstract: BACKGROUND
  The preoperative switch from local to systemic antiglaucomatous therapy and the additional application of local antiphlogistic drugs represents an important component of perioperative wound healing modulation within the framework of glaucoma filtration surgery.
  
  
  OBJECTIVE
  The aim of the present study was to compare the intraocular pressure (IOP) under a maximum local and oral antiglaucomatous therapy with or without additional application of local steroids.
  
  
  METHODS
  A retrospective clinical analysis of 121 consecutive patients who underwent primary trabeculectomy for open-angle glaucoma in 2013 and who attended the outpatient clinic at least 3 weeks before surgery was carried out. The patients were set on preoperative therapy as follows: continuation of the maximum local antiglaucomatous therapy (with or without local dexamethasone 1 mg/ml 3 times daily) or administration of 750 mg acetazolamide orally per day (with or without local steroids).
  
  
  RESULTS
  The switch to oral antiglaucomatous therapy led to a mean IOP rise of 3.14 mm Hg which was short of statistical significance (p = 0.052). The additional administration of local steroids did not significantly influence the IOP (p = 0.218). Some patients with oral acetazolamide therapy and local steroid application showed large increases in IOP up to 30 mm Hg.
  
  
  CONCLUSIONS
  The mean IOP rise of 3.14 mm Hg 3 weeks after replacement of antiglaucomatous eye drops by acetazolamide was short of missing statistical significance and seems to be clinically negligible for this relatively short period. The advantages of a lower postoperative fibrotic activity have to be weighed up against this change in IOP. Surprisingly, the effect of administration of local steroids for 3 weeks was minor compared to the effect of the switch from local to oral antiglaucomatous medication. Individual major IOP increases under the preoperative therapy change should be taken into consideration.
authors.affiliation: Klinik und Poliklinik für Augenheilkunde, Klinikum der Universität Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Deutschland. isabel.oberacher@gmx.de.
authors.forename: I
authors.initials: I
authors.lastname: Oberacher-Velten
authors.affiliation: Zentrum für klinische Studien, Klinikum der Universität Regensburg, Regensburg, Deutschland.
authors.forename: F
authors.initials: F
authors.lastname: Zeman
authors.affiliation: Klinik und Poliklinik für Augenheilkunde, Klinikum der Universität Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Deutschland.
authors.forename: F
authors.initials: F
authors.lastname: Lehmann
authors.affiliation: Klinik und Poliklinik für Augenheilkunde, Klinikum der Universität Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Deutschland.
authors.forename: T
authors.initials: T
authors.lastname: Barth
authors.affiliation: Klinik und Poliklinik für Augenheilkunde, Klinikum der Universität Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Deutschland.
authors.forename: P
authors.initials: P
authors.lastname: Peters
authors.affiliation: Klinik und Poliklinik für Augenheilkunde, Klinikum der Universität Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Deutschland.
authors.forename: H
authors.initials: H
authors.lastname: Helbig
authors.affiliation: Klinik und Poliklinik für Augenheilkunde, Klinikum der Universität Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Deutschland.
authors.forename: R
authors.initials: R
authors.lastname: Greslechner
mesh_terms: D000086:Acetazolamide / Q000494:pharmacology* / Q000627:therapeutic use*; D000284:Administration, Oral; D000368:Aged; D000369:Aged, 80 and over; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000627:therapeutic use; D003907:Dexamethasone / Q000494:pharmacology* / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005260:Female; D005901:Glaucoma / Q000188:drug therapy*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions; D011300:Preoperative Care; D012189:Retrospective Studies; D014130:Trabeculectomy
chemical_list: D000893:Anti-Inflammatory Agents; D000959:Antihypertensive Agents; D009883:Ophthalmic Solutions; D003907:Dexamethasone; D000086:Acetazolamide
keywords: Acetazolamide; Local steroids; Oral antiglaucomatous therapy; Preoperative therapy; Trabeculectomy