title: A new spectinabilin derivative with cytotoxic activity from ant-derived Streptomyces sp. 1H-GS5.
abstract: A new spectinabilin derivative (1) was isolated from the fermentation broth of the ant-derived Streptomyces sp. 1H-GS5, and the structure was elucidated by extensive spectroscopic analysis. Compound 1 showed cytotoxicity against human tumor cell lines A549, HCT-116, and HepG2 with IC50values of 9.7, 12.8, and 9.1 μg/ml, respectively, which was relative higher than that of spectinabilin.
authors.affiliation: a Life Science and Biotechnology Research Center , School of Life Science, Northeast Agricultural University , Harbin 150030 , China.
authors.forename: Chong-Xi
authors.initials: CX
authors.lastname: Liu
authors.affiliation: a Life Science and Biotechnology Research Center , School of Life Science, Northeast Agricultural University , Harbin 150030 , China.|b Department of New Drug Screening , Zhejiang Hisun Pharmaceutical Co., Ltd , Taizhou 318000 , China.
authors.forename: Shuang-He
authors.initials: SH
authors.lastname: Liu
authors.affiliation: a Life Science and Biotechnology Research Center , School of Life Science, Northeast Agricultural University , Harbin 150030 , China.
authors.forename: Jun-Wei
authors.initials: JW
authors.lastname: Zhao
authors.affiliation: a Life Science and Biotechnology Research Center , School of Life Science, Northeast Agricultural University , Harbin 150030 , China.
authors.forename: Ji
authors.initials: J
authors.lastname: Zhang
authors.affiliation: a Life Science and Biotechnology Research Center , School of Life Science, Northeast Agricultural University , Harbin 150030 , China.
authors.forename: Xiang-Jing
authors.initials: XJ
authors.lastname: Wang
authors.affiliation: a Life Science and Biotechnology Research Center , School of Life Science, Northeast Agricultural University , Harbin 150030 , China.|b Department of New Drug Screening , Zhejiang Hisun Pharmaceutical Co., Ltd , Taizhou 318000 , China.
authors.forename: Jian-Song
authors.initials: JS
authors.lastname: Li
authors.affiliation: b Department of New Drug Screening , Zhejiang Hisun Pharmaceutical Co., Ltd , Taizhou 318000 , China.
authors.forename: Ji-Dong
authors.initials: JD
authors.lastname: Wang
authors.affiliation: a Life Science and Biotechnology Research Center , School of Life Science, Northeast Agricultural University , Harbin 150030 , China.
authors.forename: Wen-Sheng
authors.initials: WS
authors.lastname: Xiang
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001000:Ants / Q000382:microbiology*; D004354:Drug Screening Assays, Antitumor; D045325:HCT116 Cells; D056945:Hep G2 Cells; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010446:Peptide Fragments / Q000737:chemistry; D011753:Pyrones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D013302:Streptomyces / Q000737:chemistry*; D013373:Substance P / Q000031:analogs & derivatives / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D010446:Peptide Fragments; D011753:Pyrones; C508401:spectinabilin; C046958:substance P (6-11), Arg(6)-Trp(7,9)-Me-Phe(8)-; D013373:Substance P
keywords: Spectinabilin derivative; Streptomyces sp. 1H-GS5; ant-derived strain; cytotoxicity