title: Chemokine receptors in allergic diseases.
abstract: Under homeostatic conditions, as well as in various diseases, leukocyte migration is a crucial issue for the immune system that is mainly organized through the activation of bone marrow-derived cells in various tissues. Immune cell trafficking is orchestrated by a family of small proteins called chemokines. Leukocytes express cell-surface receptors that bind to chemokines and trigger transendothelial migration. Most allergic diseases, such as asthma, rhinitis, food allergies, and atopic dermatitis, are generally classified by the tissue rather than the type of inflammation, making the chemokine/chemokine receptor system a key point of the immune response. Moreover, because small antagonists can easily block such receptors, various molecules have been developed to suppress the recruitment of immune cells during allergic reactions, representing potential new drugs for allergies. We review the chemokines and chemokine receptors that are important in asthma, food allergies, and atopic dermatitis and their respectively developed antagonists.
authors.affiliation: INRA, UR1268 BIA, Nantes, France.|INSERM, UMR1087, lnstitut du thorax, Nantes, France.|CNRS, UMR6291, Nantes, France.|Université de Nantes, Nantes, France.
authors.forename: L
authors.initials: L
authors.lastname: Castan
authors.affiliation: INSERM, UMR1087, lnstitut du thorax, Nantes, France.|CNRS, UMR6291, Nantes, France.|CHU de Nantes, Service de Pneumologie, Institut du thorax, Nantes, France.
authors.forename: A
authors.initials: A
authors.lastname: Magnan
authors.affiliation: INRA, UR1268 BIA, Nantes, France.
authors.forename: G
authors.initials: G
authors.lastname: Bouchaud
mesh_terms: D000818:Animals; D018927:Anti-Asthmatic Agents / Q000494:pharmacology / Q000627:therapeutic use; D001249:Asthma / Q000188:drug therapy / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D018925:Chemokines / Q000235:genetics / Q000378:metabolism; D003876:Dermatitis, Atopic / Q000188:drug therapy / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D005512:Food Hypersensitivity / Q000188:drug therapy / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D006801:Humans; D006967:Hypersensitivity / Q000188:drug therapy / Q000235:genetics / Q000276:immunology* / Q000378:metabolism*; D007107:Immune System / Q000166:cytology / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D019707:Receptors, Chemokine / Q000037:antagonists & inhibitors / Q000378:metabolism*
chemical_list: D018927:Anti-Asthmatic Agents; D018925:Chemokines; D019707:Receptors, Chemokine
keywords: asthma; atopic dermatitis; chemokine; chemokine receptor; food allergy