title: Cycloartane-type triterpenoids from Astragalus hoantchy French.
abstract: A new cycloartane-type triterpenoid, 3β-acetoxy-9β,19-cyclolanost-24E-ene-1α,16β-diol-27-O-β-d-glucopyranoside (1), together with three known ones (2-4) were isolated from the aerial parts of Astragalus hoantchy. The structure of compound 1 was elucidated by detailed spectroscopic analyses including 1D and 2D NMR, HRESIMS, and IR experiments. All of the four compounds were isolated from A. hoantchy for the first time. The antifungal activities of compounds 1-4 against a phytopathogenic fungus (Alternaria solani) were evaluated with the result that compound 3 exhibited a moderate activity with an IC50value of 284 μg/mL.
authors.affiliation: a Key Laboratory of Chemistry of Northwestern Plant Resources of CAS and Key Laboratory for Natural Medicine of Gansu Province , Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences , Lanzhou , P.R. China.
authors.forename: Kai
authors.initials: K
authors.lastname: Guo
authors.affiliation: a Key Laboratory of Chemistry of Northwestern Plant Resources of CAS and Key Laboratory for Natural Medicine of Gansu Province , Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences , Lanzhou , P.R. China.
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: He
authors.affiliation: b Institute of Biology , Gansu Academy of Sciences , Lanzhou , P.R. China.
authors.forename: Dengxue
authors.initials: D
authors.lastname: Lu
authors.affiliation: c Fisheries Research Institute of Gansu Province , Lanzhou , P.R. China.
authors.forename: Yanping
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: a Key Laboratory of Chemistry of Northwestern Plant Resources of CAS and Key Laboratory for Natural Medicine of Gansu Province , Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences , Lanzhou , P.R. China.
authors.forename: Xiuzhuang
authors.initials: X
authors.lastname: Li
authors.affiliation: a Key Laboratory of Chemistry of Northwestern Plant Resources of CAS and Key Laboratory for Natural Medicine of Gansu Province , Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences , Lanzhou , P.R. China.
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Yan
authors.affiliation: a Key Laboratory of Chemistry of Northwestern Plant Resources of CAS and Key Laboratory for Natural Medicine of Gansu Province , Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences , Lanzhou , P.R. China.
authors.forename: Bo
authors.initials: B
authors.lastname: Qin
mesh_terms: D000528:Alternaria / Q000187:drug effects; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D027883:Astragalus Plant / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D013057:Spectrum Analysis; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D000935:Antifungal Agents; D014315:Triterpenes; C085352:cycloartane
keywords: Astragalus hoantchy; Leguminosae; antifungal activity; cycloartane triterpenoid