title: Molecular design of cytocompatible amphiphilic redox-active polymers for efficient extracellular electron transfer.
abstract: For electrochemical regulations of the intracellular metabolisms, lipophilic electron mediators with cell membrane permeability have been conventionally used. We have recently developed amphiphilic, cell-membrane permeable polymer composed of hydrophilic 2-methacryloyloxyethyl phosphorylcholine and hydrophobic redox-active units as a new category of electron mediator. The advantage of the redox active polymer is that we can obtain appropriate molecules in a synthetic bottom-up manner. Here we report that the rate of the extracellular electron transfer (EET) through the redox active polymer can be regulated by sophisticated molecular design of the polymers. It was also shown that the cellular metabolism of yeast Saccharomyces cerevisiae was regulated by using the polymer with the highest EET rate.
authors.affiliation: Department of Applied Chemistry, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kaneko
authors.affiliation: Research Center for Advanced Science and Technology, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8904, Japan.
authors.forename: Masahito
authors.initials: M
authors.lastname: Ishikawa
authors.affiliation: Department of Applied Chemistry, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan. Electronic address: hashimoto@light.t.u-tokyo.ac.jp.
authors.forename: Kazuhito
authors.initials: K
authors.lastname: Hashimoto
authors.affiliation: Research Center for Solar Energy Chemistry, Osaka University, 1-3, Machikaneyama, Toyonaka, Osaka 560-8531, Japan. Electronic address: nakanishi@chem.es.osaka-u.ac.jp.
authors.forename: Shuji
authors.initials: S
authors.lastname: Nakanishi
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry / Q000494:pharmacology; D015195:Drug Design; D004579:Electron Transport / Q000187:drug effects; D048168:Escherichia coli K12 / Q000166:cytology; D005110:Extracellular Space / Q000187:drug effects* / Q000378:metabolism*; D057927:Hydrophobic and Hydrophilic Interactions; D010767:Phosphorylcholine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D011109:Polymethacrylic Acids / Q000737:chemistry* / Q000494:pharmacology*; D012441:Saccharomyces cerevisiae / Q000166:cytology
chemical_list: D001672:Biocompatible Materials; D011109:Polymethacrylic Acids; C115766:poly(2-methacryloyloxyethyl-phosphorylcholine); D010767:Phosphorylcholine
keywords: Electron mediator; Extracellular electron transfer; Metabolism; Polymer