title: Chasing dizzy chimera: Diagnosis of combined peripheral and central vestibulopathy.
abstract: Diagnosis of combined peripheral and central vestibulopathy remains a challenge since the findings from peripheral vestibular involvements may overshadow those from central vestibular disorders or vice versa. The aim of this study was to enhance detection of these intriguing disorders by characterizing the clinical features and underlying etiologies. We had recruited 55 patients with combined peripheral and central vestibulopathy at the Dizziness Clinic of Seoul National University Bundang Hospital from 2003 to 2013. Peripheral vestibular involvement was determined by decreased caloric responses in either ear, and central vestibulopathy was diagnosed with obvious central vestibular signs or the lesions documented on MRIs to involve the central vestibular structures. Combined peripheral and central vestibulopathy could be classified into four types according to the patterns of vestibular presentation. Infarctions were the most common cause of acute unilateral cases while cerebellopontine angle tumors were mostly found in chronic unilateral ones. Wernicke encephalopathy and degenerative disorders were common in acute and chronic bilateral disorders. Twenty five (45.5%) patients showed only vestibular findings with or without auditory involvements, but association with gaze-evoked nystagmus, impaired smooth pursuit or central types of head shaking nystagmus indicated a central vestibular involvement in most of them (23/25, 92.0%). Given the requirements for urgent treatments and potentially grave prognosis of combined vestibulopathy, central signs should be sought even in patients with clinical or laboratory features of peripheral vestibulopathy. Scrutinized bedside evaluation, however, secured the diagnosis in almost all the patients with combined vestibulopathy.
authors.affiliation: Department of Neurology, Pusan National University Hospital, Pusan National University School of Medicine and Medical Research Institute, Pusan, Republic of Korea.
authors.forename: Seo-Young
authors.initials: SY
authors.lastname: Choi
authors.affiliation: Department of Biomedical Laboratory Science, Kyungdong University, Goseong, Republic of Korea.
authors.forename: Hyo-Jung
authors.initials: HJ
authors.lastname: Kim
authors.affiliation: Department of Neurology, Seoul National University College Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea. Electronic address: jisookim@snu.ac.kr.
authors.forename: Ji-Soo
authors.initials: JS
authors.lastname: Kim
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000000981:diagnostic imaging; D002493:Central Nervous System Diseases / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010523:Peripheral Nervous System Diseases / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology; D015837:Vestibular Diseases / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology*; D014724:Vestibular Function Tests
keywords: Head impulse test; Infarction; Tumor; Vertigo; Vestibular disorder; Vestibulopathy; Wernicke's encephalopathy