title: Association Between Oxytocin Receptor Genotype, Maternal Care, and Eating Disorder Behaviours in a Community Sample of Women.
abstract: This study aimed to investigate associations between oxytocin receptor gene (OXT-R) polymorphisms (rs53576 and rs2254298), their interaction with maternal care (GxE), and ED behaviours in a community sample. We studied 3698 women from the Avon Longitudinal Study of Parents and Children (ALSPAC) who participated in a two-phase prevalence study of lifetime ED and had genotype data. The GG rs53576 genotype was associated with binge eating and purging, and the rs2254298 AG/AA genotype with restrictive eating lifetime. In addition, the rs2254298 AG/AA genotype interacted with poor maternal care to increase the odds of binge eating and purging (odds ratio = 4.40 (95% confidence intervals: 1.11-17.4)). This study replicates previous findings of an association between OXT-R polymorphisms and ED, and it is the first to show an interaction between OXT-R genotype and poor maternal care. As such, these findings highlight the important role of oxytocin in understanding the pathophysiology of ED. © 2016 The Authors European Eating Disorders Review published by Eating Disorders Association and John Wiley & Sons Ltd.
authors.affiliation: Eating and Weight Disorders Program, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.|Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.|Institute of Child Health, University College London, London, UK.
authors.forename: Nadia
authors.initials: N
authors.lastname: Micali
authors.affiliation: Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.|Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
authors.forename: Marta
authors.initials: M
authors.lastname: Crous-Bou
authors.affiliation: Eating Disorders Research Unit, Psychological Medicine, Institute of Psychiatry, King's College London, London, UK.
authors.forename: Janet
authors.initials: J
authors.lastname: Treasure
authors.affiliation: Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Lawson
mesh_terms: D000328:Adult; D002648:Child; D001068:Feeding and Eating Disorders / Q000235:genetics* / Q000523:psychology; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008137:Longitudinal Studies; D008425:Maternal Behavior; D011110:Polymorphism, Genetic; D018045:Receptors, Oxytocin / Q000235:genetics*; D006113:United Kingdom
chemical_list: D018045:Receptors, Oxytocin
keywords: ALSPAC; eating disorders; gene-environment interaction; oxytocin