title: A Correlative Classification Study of Schizophrenic Patients with Results of Clinical Evaluation and Structural Magnetic Resonance Images.
abstract: Patients with schizophrenia suffer from symptoms such as hallucination and delusion. There are currently a number of publications that discuss the treatment, diagnosis, prognosis, and damage in schizophrenia. This study utilized joint independent component analysis to process the images of GMV and WMV and incorporated the Wisconsin card sorting test (WCST) and the positive and negative syndrome scale (PANSS) to examine the correlation of obtained brain characteristics. We also used PANSS score to classify schizophrenic patients into acute and subacute cases, to analyze the brain structure differences. Finally, we used brain structure images and the error rate of the WCST as eigenvalues in support vector machine learning and classification. The results of this study showed that the frontal and temporal lobes of a normal brain are more apparent than those of a schizophrenia brain. The highest level of classification recognition reached 91.575%, indicating that the WCST error rate and characteristic changes in brain structure volume can be used to effectively distinguish schizophrenia and normal brains. Similarly, this result confirmed that the WCST and brain structure volume are correlated with the differences between schizophrenia and normal participants.
authors.affiliation: Institute of Biomedical Engineering, National Cheng Kung University, Tainan 701, Taiwan.
authors.forename: Wen-Lin
authors.initials: WL
authors.lastname: Chu
authors.affiliation: Institute of Biomedical Engineering, National Cheng Kung University, Tainan 701, Taiwan; Department of Psychiatry, Taichung Veterans General Hospital, Chiayi Branch, Chiayi 600, Taiwan.
authors.forename: Min-Wei
authors.identifier: 0000-0003-0457-0804
authors.initials: MW
authors.lastname: Huang
authors.affiliation: Department of Aeronautics and Astronautics, National Cheng Kung University, Tainan 701, Taiwan.
authors.forename: Bo-Lin
authors.initials: BL
authors.lastname: Jian
authors.affiliation: Institute of Biomedical Engineering, National Cheng Kung University, Tainan 701, Taiwan.
authors.forename: Chih-Yao
authors.initials: CY
authors.lastname: Hsu
authors.affiliation: Institute of Biomedical Engineering, National Cheng Kung University, Tainan 701, Taiwan.
authors.forename: Kuo-Sheng
authors.identifier: 0000-0002-0913-246X
authors.initials: KS
authors.lastname: Cheng
mesh_terms: D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D001523:Mental Disorders; D008875:Middle Aged; D009483:Neuropsychological Tests; D012559:Schizophrenia / Q000145:classification* / Q000175:diagnosis / Q000000981:diagnostic imaging*; D012565:Schizophrenic Psychology; D013702:Temporal Lobe / Q000000981:diagnostic imaging