title: Transperitoneal Enucleation of a Kidney Transplant Allograft Renal Cell Carcinoma.
abstract: Development of malignancy after solid-organ trans?lant is a well-known long-term complication of immunosuppressive therapy. Thus far, there are no specific oncologic recommendations regarding management of de novo tumors in transplanted kidneys. Here, we present the case of a 63-year-old male patient who developed a de novo renal cell carcinoma 6 years after the transplant procedure. The patient underwent nephron-sparing surgery with transperitoneal enucleation of the tumor. We discuss the decision-making process and the operative challenges that we faced. We conclude that this technique should be considered as a therapeutic strategy for selected patients so that transplant nephrectomy can be avoided.
authors.affiliation: From the Department of Renal and Pancreas Transplantation, Manchester Royal Infirmary, Manchester, United Kingdom.
authors.forename: Ioannis
authors.initials: I
authors.lastname: Sarantitis
authors.forename: Ravi
authors.initials: R
authors.lastname: Pararajasingam
authors.forename: Bence
authors.initials: B
authors.lastname: Forgacs
authors.forename: Helen
authors.initials: H
authors.lastname: Denley
authors.forename: Grahame
authors.initials: G
authors.lastname: Wood
authors.forename: Titus
authors.initials: T
authors.lastname: Augustine
mesh_terms: D064591:Allografts; D002292:Carcinoma, Renal Cell / Q000139:chemically induced / Q000276:immunology / Q000473:pathology / Q000601:surgery*; D000066491:Clinical Decision-Making; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D007676:Kidney Failure, Chronic / Q000175:diagnosis / Q000601:surgery*; D007680:Kidney Neoplasms / Q000139:chemically induced / Q000276:immunology / Q000473:pathology / Q000601:surgery*; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D059351:Organ Sparing Treatments; D012307:Risk Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents