title: Coding and Plasticity in the Mammalian Thermosensory System.
abstract: Perception of the thermal environment begins with the activation of peripheral thermosensory neurons innervating the body surface. To understand how temperature is represented in vivo, we used genetically encoded calcium indicators to measure temperature-evoked responses in hundreds of neurons across the trigeminal ganglion. Our results show how warm, hot, and cold stimuli are represented by distinct population responses, uncover unique functional classes of thermosensory neurons mediating heat and cold sensing, and reveal the molecular logic for peripheral warmth sensing. Next, we examined how the peripheral somatosensory system is functionally reorganized to produce altered perception of the thermal environment after injury. We identify fundamental transformations in sensory coding, including the silencing and recruitment of large ensembles of neurons, providing a cellular basis for perceptual changes in temperature sensing, including heat hypersensitivity, persistence of heat perception, cold hyperalgesia, and cold analgesia.
authors.affiliation: Howard Hughes Medical Institute and Departments of Biochemistry and Molecular Biophysics and Neuroscience, Columbia College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
authors.forename: David A
authors.initials: DA
authors.lastname: Yarmolinsky
authors.affiliation: Howard Hughes Medical Institute and Departments of Biochemistry and Molecular Biophysics and Neuroscience, Columbia College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
authors.forename: Yueqing
authors.initials: Y
authors.lastname: Peng
authors.affiliation: National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.
authors.forename: Leah A
authors.initials: LA
authors.lastname: Pogorzala
authors.affiliation: Howard Hughes Medical Institute and Departments of Biochemistry and Molecular Biophysics and Neuroscience, Columbia College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Rutlin
authors.affiliation: National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.
authors.forename: Mark A
authors.initials: MA
authors.lastname: Hoon
authors.affiliation: Howard Hughes Medical Institute and Departments of Biochemistry and Molecular Biophysics and Neuroscience, Columbia College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA. Electronic address: cz2195@columbia.edu.
authors.forename: Charles S
authors.initials: CS
authors.lastname: Zuker
mesh_terms: D000818:Animals; D002056:Burns / Q000378:metabolism* / Q000503:physiopathology; D003080:Cold Temperature; D006358:Hot Temperature; D006930:Hyperalgesia / Q000378:metabolism* / Q000503:physiopathology; D006941:Hyperesthesia / Q000378:metabolism* / Q000503:physiopathology; D051379:Mice; D018345:Mice, Knockout; D008822:Mice, Transgenic; D009473:Neuronal Plasticity; D009474:Neurons / Q000378:metabolism* / Q000502:physiology; D000074025:TRPA1 Cation Channel; D050053:TRPM Cation Channels / Q000235:genetics / Q000378:metabolism; D050916:TRPV Cation Channels / Q000235:genetics / Q000378:metabolism*; D013697:Thermosensing / Q000502:physiology*; D050051:Transient Receptor Potential Channels / Q000235:genetics / Q000378:metabolism; D012668:Trigeminal Ganglion / Q000166:cytology* / Q000378:metabolism / Q000502:physiology
chemical_list: D000074025:TRPA1 Cation Channel; D050053:TRPM Cation Channels; C492297:TRPM8 protein, mouse; D050916:TRPV Cation Channels; C493921:TRPV1 protein, mouse; D050051:Transient Receptor Potential Channels; C475685:Trpa1 protein, mouse
keywords: TRP channels; changes in peripheral coding; injury; sensory coding; temperature representation; warmth sensing