title: Nontraditional Methods to Evaluate Wound Healing.
abstract: BACKGROUND
  Traditional evaluation of wound healing is sometimes subjective. It is necessary to develop qualitative and quantitative methods to enable more efficient and accurate evaluation of wounds. Recently, new techniques have been introduced and the correspondence between these techniques and clinician judgment is critical.
  
  
  OBJECTIVE
  Some nontraditional techniques that analyze wound healing were reviewed, which include measurements of the wound area, tissue color, skin barrier function, skin humidity, and keratinocyte morphology.
  
  
  METHODS
  This review article is based on medical research that focuses on the evaluation of wound healing.
  
  
  RESULTS
  Software-based and advanced device-based techniques generally provide more accurate and precise results than traditional ones, such as the ruler-based technique. Measurement of tissue color can also help to identify the type of tissue. Evaluation of skin barrier function can assist clinicians to analyze functional restoration of skin, whereas skin humidity demonstrates the exudate production status of the wound. In addition, keratinocyte morphology in the wound bed indicates quality of wound healing and side effects of treatment.
  
  
  CONCLUSIONS
  There is no gold standard method for qualitative and quantitative evaluation of wound healing. It is important to understand the type of wound, sample size, results obtained, advantages, and limitations of each technique.
authors.affiliation: *All authors are affiliated with the Bioactive Resources for Innovative Clinical Applications Research Unit and Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand.
authors.forename: Sukhontha
authors.initials: S
authors.lastname: Hasatsri
authors.forename: Pornanong
authors.initials: P
authors.lastname: Aramwit
mesh_terms: D019317:Evidence-Based Medicine; D017408:Guidelines as Topic; D006801:Humans; D010146:Pain / Q000209:etiology; D010780:Photogrammetry / Q000379:methods; D000068997:Smartphone; D012984:Software; D016896:Treatment Outcome; D064232:Visual Analog Scale; D014945:Wound Healing; D014947:Wounds and Injuries / Q000150:complications / Q000473:pathology*