title: Crizotinib for ROS1 patients: One small step in biomarker testing, one giant leap for advanced NSCLC patients.
authors.affiliation: Department of Medical Oncology, Hospital Universitari i Politècnic La FE, Av. Fernando Abril Martorell 106, 46026 Valencia, Spain. Electronic address: juan_osc@gva.es.
authors.forename: Oscar
authors.initials: O
authors.lastname: Juan
authors.affiliation: Lung Unit, Royal Marsden Hospital, London SW3 6JJ, UK; National Heart & Lung Institute, Faculty of Medicine, Imperial College London, Guy Scadding Building, Cale Street, London SW3 6LY, UK; The Institute of Cancer Research, 123 Old Brompton Road, London SW7 3RP, UK.
authors.forename: Sanjay
authors.initials: S
authors.lastname: Popat
mesh_terms: D014408:Biomarkers, Tumor; D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis* / Q000188:drug therapy* / Q000401:mortality; D000077547:Crizotinib; D005820:Genetic Testing; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000188:drug therapy* / Q000401:mortality; D058990:Molecular Targeted Therapy; D009367:Neoplasm Staging; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use*; D011505:Protein-Tyrosine Kinases / Q000235:genetics* / Q000378:metabolism; D011518:Proto-Oncogene Proteins / Q000235:genetics* / Q000378:metabolism; D011720:Pyrazoles / Q000627:therapeutic use*; D011725:Pyridines / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor; D047428:Protein Kinase Inhibitors; D011518:Proto-Oncogene Proteins; D011720:Pyrazoles; D011725:Pyridines; D000077547:Crizotinib; D011505:Protein-Tyrosine Kinases; C062333:ROS1 protein, human
keywords: Crizotinib; Non-small cell lung cancer; ROS1 fusions; Targeted therapy