title: Unexpected Diffuse 18F-NaF Uptake in the Lung Parenchyma in a Patient With Severe Hypercalcemia Due to Myelomatosis.
abstract: An 84-year-old man was admitted to the intensive care unit because of hypercalcemic crisis leading to acute renal failure needing dialysis. The patient had no other history of illness. However, because prostate-specific antigen levels were increased, the patient was referred to F-NaF PET/CT on suspicion of active skeletal metastases. The patient was finally diagnosed with myelomatosis. Although the skeletal uptake of F-NaF was without signs of focal metastasis, the F-NaF PET/CT scanning surprisingly revealed diffuse high accumulation of F-NaF in the lung parenchyma, possibly because of calcium deposition in the lung parenchyma associated to amyloidosis seen in patients with myelomatosis.
authors.affiliation: From the Departments of *Clinical Physiology and Nuclear Medicine, and †Radiology, Bispebjerg University Hospital, Copenhagen; and ‡Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Ali
authors.initials: A
authors.lastname: Asmar
authors.forename: Lene
authors.initials: L
authors.lastname: Simonsen
authors.forename: Birgitte
authors.initials: B
authors.lastname: Svolgaard
authors.forename: Jens
authors.initials: J
authors.lastname: Bülow
mesh_terms: D000369:Aged, 80 and over; D000686:Amyloidosis / Q000000981:diagnostic imaging* / Q000209:etiology; D001842:Bone and Bones / Q000000981:diagnostic imaging*; D002114:Calcinosis / Q000000981:diagnostic imaging* / Q000209:etiology; D003937:Diagnosis, Differential; D005462:Fluorine Radioisotopes; D006801:Humans; D006934:Hypercalcemia / Q000175:diagnosis* / Q000209:etiology; D008171:Lung Diseases / Q000000981:diagnostic imaging* / Q000209:etiology; D008297:Male; D009101:Multiple Myeloma / Q000150:complications / Q000000981:diagnostic imaging*; D000072078:Positron Emission Tomography Computed Tomography; D049268:Positron-Emission Tomography; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000097:blood / Q000175:diagnosis; D012720:Severity of Illness Index; D012969:Sodium Fluoride; D014057:Tomography, X-Ray Computed
chemical_list: D005462:Fluorine Radioisotopes; D012969:Sodium Fluoride; D017430:Prostate-Specific Antigen