title: Polyarteritis nodosa presenting as peripheral vascular disease and acute limb ischemia.
abstract: Acute limb ischemia and peripheral vascular disease (PVD) are unusual presentations of polyarteritis nodosa (PAN). Here, we present a case with PVD of both lower limbs leading to foot claudication. Digital subtraction angiography showed narrowing, irregularity, and occlusion of both lower limb arteries with no involvement of the abdomen visceral arteries. Based on significant weight loss, diastolic blood pressure >90 mmHg, myalgia, testicular pain, and angiographic abnormalities in medium-sized arteries, he was diagnosed as having PAN. He was treated with corticosteroid and bolus intravenous cyclophosphamide following which he had prompt and near-complete recovery of the symptoms without any tissue loss.
authors.affiliation: Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
authors.forename: A
authors.initials: A
authors.lastname: Shukla
authors.affiliation: Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
authors.forename: A
authors.initials: A
authors.lastname: Aggarwal
mesh_terms: D015746:Abdominal Pain / Q000209:etiology; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000783:Aneurysm / Q000000981:diagnostic imaging*; D015901:Angiography, Digital Subtraction / Q000379:methods*; D003520:Cyclophosphamide / Q000627:therapeutic use; D006801:Humans; D007383:Intermittent Claudication / Q000209:etiology*; D007511:Ischemia / Q000209:etiology*; D008775:Methylprednisolone; D016491:Peripheral Vascular Diseases / Q000000981:diagnostic imaging*; D010488:Polyarteritis Nodosa / Q000150:complications / Q000000981:diagnostic imaging* / Q000188:drug therapy; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000305:Adrenal Cortex Hormones; D003520:Cyclophosphamide; D008775:Methylprednisolone