title: Optic disc pit maculopathy: when and how to treat? A review of the pathogenesis and treatment options.
abstract: Optic disc pit (ODP) is a rare congenital anomaly of the optic disc, which can be complicated by a maculopathy associated with progressive visual loss. Optic disc pits are usually unilateral and sporadic in occurrence, and the development of maculopathy is unpredictable with no known triggers. Optic disc pit maculopathy (ODP-M) is characterized by intraretinal and subretinal fluid at the macula, causing visual deterioration. The source of this fluid is still unclear, and several competing theories have suggested it may be vitreous fluid, cerebrospinal fluid, leakage from blood vessels at the base of the pit or leakage from the choroid. The mechanism of pathogenesis of ODP-M has not been fully elucidated, but vitreous liquefaction and traction and pressure gradients within the eye have been implicated to be involved. There are no clear guidelines on the management of patients with ODP-M, and numerous techniques have been described, including laser photocoagulation, intravitreal gas injection, macular buckling and pars plana vitrectomy with many different modifications. The majority of reports describe small series, and as there are no comparative studies there is no consensus regarding the optimal treatment for ODP-M. This review discusses the literature on the possible sources of fluid and mechanisms of pathogenesis in ODP-M, as well as the wide array of treatment modalities and their results. Based on these, a set of recommended key concepts for the timing and choice of treatment for these challenging are presented.
authors.affiliation: grid.413449.f0000000105186922Department of Ophthalmology, Tel Aviv Sourasky Medical Center, 6 Weitzman st., Tel Aviv, 64239 Israel ; grid.12136.370000000419370546Affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel ; grid.413079.80000000097528549Department of Ophthalmology and Visual Science, UC Davis Medical Center, Sacramento, CA USA.
authors.forename: Elad
authors.initials: E
authors.lastname: Moisseiev
authors.affiliation: grid.413795.d0000000121072845Department of Ophthalmology, Sheba Medical Center, Ramat Gan, Israel ; grid.12136.370000000419370546Affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Joseph
authors.initials: J
authors.lastname: Moisseiev
authors.affiliation: grid.413449.f0000000105186922Department of Ophthalmology, Tel Aviv Sourasky Medical Center, 6 Weitzman st., Tel Aviv, 64239 Israel ; grid.12136.370000000419370546Affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Anat
authors.initials: A
authors.lastname: Loewenstein
keywords: Optic disc pit maculopathy; Review; Treatment; Vitrectomy