title: [Autoantibody-associated autoimmune encephalitis and cerebellitis : Clinical presentation, diagnostic work-up and treatment].
abstract: There is no other field of neurology where clinically relevant serological biomarkers have witnessed a surge in importance over the past decade resembling that in autoimmune encephalitis and cerebellitis. A multitude of newly discovered neuronal autoantibodies facilitate early diagnosis, estimation of prognosis, and therapeutic decision-making. However, this has led to growing uncertainty with regard to meaningful patient selection, the appropriate extent of testing, and management of seronegative cases. This review summarizes the essential aspects of the clinical presentation, diagnostic work-up, pathophysiology, and treatment of autoimmune encephalitis and cerebellitis.
authors.affiliation: Neurologische Universitätsklinik, Universität Ulm und Universitäts- und Rehabilitationskliniken Ulm, Ulm, Deutschland.
authors.forename: J
authors.initials: J
authors.lastname: Lewerenz
authors.affiliation: AG Molekulare Neuroimmunologie, Neurologische Klinik, Universität Heidelberg, Heidelberg, Deutschland.
authors.forename: S
authors.initials: S
authors.lastname: Jarius
authors.affiliation: AG Molekulare Neuroimmunologie, Neurologische Klinik, Universität Heidelberg, Heidelberg, Deutschland.
authors.forename: B
authors.initials: B
authors.lastname: Wildemann
authors.affiliation: Bereich Neuroimmunologie, Institut für Klinische Chemie, Universitätsklinikum Schleswig-Holstein, Kiel/Lübeck, Deutschland.|Klinik für Neurologie, Universitätsklinikum Schleswig-Holstein, Lübeck, Deutschland.
authors.forename: K-P
authors.initials: KP
authors.lastname: Wandinger
authors.affiliation: Bereich Neuroimmunologie, Institut für Klinische Chemie, Universitätsklinikum Schleswig-Holstein, Kiel/Lübeck, Deutschland. Frank.Leypoldt@uksh.de.|Klinik für Neurologie, Universitätsklinikum Schleswig-Holstein, Kiel, Deutschland. Frank.Leypoldt@uksh.de.
authors.forename: F
authors.initials: F
authors.lastname: Leypoldt
mesh_terms: D001323:Autoantibodies / Q000097:blood*; D015415:Biomarkers / Q000097:blood*; D002526:Cerebellar Diseases / Q000097:blood / Q000175:diagnosis* / Q000628:therapy*; D003937:Diagnosis, Differential; D004660:Encephalitis / Q000097:blood / Q000175:diagnosis* / Q000628:therapy*; D019317:Evidence-Based Medicine; D050031:Hashimoto Disease / Q000097:blood / Q000175:diagnosis* / Q000628:therapy*
chemical_list: D001323:Autoantibodies; D015415:Biomarkers
keywords: Autoimmune encephalitis; Biomarkers; Limbic encephalitis; Neuronal auto-antibody; Serology