title: Root bark of Morus alba ameliorates the depressive-like behaviors in diabetic rats.
abstract: Diabetes-induced depression is one of the severe chronic complications of diabetes mellitus. Up to now, there are only a few effective medicines to prevent or manage the co-morbidity of diabetes and depression. The present study was to investigate the effect of root bark of Morus alba (RBM) on depressive-like behaviors in the diabetic rats established by a high fat diet and a low dose of streptozotocin. Depressive-like behaviors were measured by the open field test, locomotor activity test and forced swimming test. Plasma glucose and lipid parameters were also measured. Expression of Brain-derived neurotrophic factor (BDNF) and phosphorylation of extracellular signal-regulated kinase (ERK) and Akt in the prefrontal cortex (PFC) were assessed. The results showed that a 4-week administration of RBM (10g/kg, ig) significantly reversed the depressive-like behaviors. BDNF expression and phosphorylation of ERK and Akt were increased in the PFC following RBM treatment in the diabetic rats. The data demonstrated that RBM could improve the depressive-like behaviors induced by diabetes, suggesting a therapeutic potential of RBM for the diabetes-associated depression.
authors.affiliation: Runliang Diabetes Laboratory, Diabetes Research Center, Ningbo University, 818 Fenghua Road, 315211 Ningbo, Zhejiang, PR China.
authors.forename: Mei
authors.initials: M
authors.lastname: Ye
authors.affiliation: Runliang Diabetes Laboratory, Diabetes Research Center, Ningbo University, 818 Fenghua Road, 315211 Ningbo, Zhejiang, PR China.
authors.forename: Yuting
authors.initials: Y
authors.lastname: Ke
authors.affiliation: Runliang Diabetes Laboratory, Diabetes Research Center, Ningbo University, 818 Fenghua Road, 315211 Ningbo, Zhejiang, PR China.
authors.forename: Bingyang
authors.initials: B
authors.lastname: Liu
authors.affiliation: Runliang Diabetes Laboratory, Diabetes Research Center, Ningbo University, 818 Fenghua Road, 315211 Ningbo, Zhejiang, PR China.
authors.forename: Yanyan
authors.initials: Y
authors.lastname: Yuan
authors.affiliation: Runliang Diabetes Laboratory, Diabetes Research Center, Ningbo University, 818 Fenghua Road, 315211 Ningbo, Zhejiang, PR China.
authors.forename: Fuyan
authors.initials: F
authors.lastname: Wang
authors.affiliation: Runliang Diabetes Laboratory, Diabetes Research Center, Ningbo University, 818 Fenghua Road, 315211 Ningbo, Zhejiang, PR China.
authors.forename: Shizhong
authors.initials: S
authors.lastname: Bu
authors.affiliation: Department of Gynaecology and Obstetrics, Ningbo Medical Center, Lihuili Eastern Hospital, 1111 Jiangnan Road, 315040 Ningbo, Zhejiang, PR China. Electronic address: doctorzhangys@139.com.
authors.forename: Yisheng
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000818:Animals; D001522:Behavior, Animal; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism; D003863:Depression / Q000139:chemically induced* / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental; D048049:Extracellular Signal-Regulated MAP Kinases / Q000378:metabolism; D006624:Hippocampus / Q000378:metabolism; D008297:Male; D031625:Morus / Q000737:chemistry*; D010766:Phosphorylation; D024301:Plant Bark / Q000737:chemistry*; D017207:Rats, Sprague-Dawley
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D048049:Extracellular Signal-Regulated MAP Kinases
keywords: BDNF; Depression; Diabetes; PFC; Root bark of Morus alba; Streptozocin