title: Feminizing Adrenocortical Carcinoma with Distinct Histopathological Findings.
abstract: We herein present a 60-year-old man with adrenocortical carcinoma who had gynecomastia. An endocrinological examination revealed increased levels of serum estradiol and dehydroepiandrosterone-sulfate (DHEA-S) and reduced levels of free testosterone. Magnetic resonance imaging showed an adrenal tumor with heterogeneous intensity. Iodine-131 adosterol scintigraphy showed an increased uptake at the same site. Because feminizing adrenocortical carcinoma was suspected, right adrenalectomy was performed; the pathological diagnosis was adrenocortical carcinoma. The results of immunostaining indicated a virilizing tumor. Aromatase activity was identified on RT-PCR. As disorganized steroidogenesis is pathologically present in adrenocortical carcinoma, this diagnosis should be made with caution.
authors.affiliation: Department of Endocrinology and Diabetes, Saitama Medical University, Japan.
authors.forename: Masako
authors.initials: M
authors.lastname: Hatano
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Takenaka
authors.forename: Ikuo
authors.initials: I
authors.lastname: Inoue
authors.forename: Keiko
authors.initials: K
authors.lastname: Homma
authors.forename: Tomonobu
authors.initials: T
authors.lastname: Hasegawa
authors.forename: Hisanobu
authors.initials: H
authors.lastname: Sasano
authors.forename: Takuya
authors.initials: T
authors.lastname: Awata
authors.forename: Shigehiro
authors.initials: S
authors.lastname: Katayama
mesh_terms: D000306:Adrenal Cortex Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D000315:Adrenalectomy; D018268:Adrenocortical Carcinoma / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood; D005262:Feminization / Q000209:etiology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging
chemical_list: D019314:Dehydroepiandrosterone Sulfate