title: Can body mass index predict the outcome of diffuse large B-cell lymphoma? A single-center retrospective study in China.
abstract: We carried out a single-center retrospective study to assess the predictive value of body mass index (BMI) in the outcome of Chinese patients with diffuse large B-cell lymphoma (DLBCL). 143 eligible patients were enrolled between January 2008 and May 2015. These patients were stratified into two groups, 74 patients in low BMI group (BMI <23.0 kg/m2) and 69 patients in high BMI group (BMI ≥23.0 kg/m2). We compared the baseline characteristics, primary response, and survival outcome in two groups. Well-known influence factors were similar between the two groups, while gender was not (p = .023) but did not act as a risk factor. No association between BMI and primary response was observed. Patients with high BMI were inclined to have better overall survival (OS) (p = .018), but we didn't find an association in progression-free survival (PFS) (p = .067). We also found a sex-dependent effect of BMI on OS, with high BMI increased OS in female patients (p = .027) but showed no correlation in male patients (p = .310).
authors.affiliation: a Department of Hematology , Shengjing Hospital of China Medical University , Shenyang , China.
authors.forename: Tong
authors.initials: T
authors.lastname: Li
authors.affiliation: a Department of Hematology , Shengjing Hospital of China Medical University , Shenyang , China.
authors.forename: Zhuo-Gang
authors.initials: ZG
authors.lastname: Liu
authors.affiliation: a Department of Hematology , Shengjing Hospital of China Medical University , Shenyang , China.
authors.forename: Pei-Qi
authors.initials: PQ
authors.lastname: Liang
authors.affiliation: a Department of Hematology , Shengjing Hospital of China Medical University , Shenyang , China.
authors.forename: Hong-Tao
authors.initials: HT
authors.lastname: Wang
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D015415:Biomarkers; D015992:Body Mass Index; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D016403:Lymphoma, Large B-Cell, Diffuse / Q000188:drug therapy / Q000453:epidemiology* / Q000401:mortality; D008297:Male; D011159:Population Surveillance; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers
keywords: Body mass index; clinical outcome; diffuse large B-cell lymphoma