title: Prognostic role of histological regression in cutaneous melanoma.
abstract: Histological regression in primary cutaneous melanoma occurs in 10-35% of cases. Although there is a large body of literature on histological regression and prognosis in melanoma patients, not clear data concerning this feature has been reported. In the current review, a comprehensive overview of the main aspects of regression will be provided. The clinical utility of regression as a prognostic factor has been challenged recently. Nowadays evidences reported that this feature is protective on SLN metastases. Despite its association with poor prognostic factors, it maintained a favourable prognostic role in many different survival studies.
authors.affiliation: Section of Dermatology, Department of Medical Sciences, University of Turin, Turin, Italy - simone.ribero@unito.it.|Section of Dermatologic Surgery, Department of Oncology, University Hospital &quot;Città della Salute e della Scienza di Torino&quot;, Turin, Italy - simone.ribero@unito.it.
authors.forename: Simone
authors.initials: S
authors.lastname: Ribero
authors.affiliation: Section of Surgical Pathology, Department of Medical Sciences, University of Turin, Turin, Italy.
authors.forename: Simona
authors.initials: S
authors.lastname: Osella-Abate
authors.affiliation: Unit of Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.
authors.forename: Emi
authors.initials: E
authors.lastname: Dika
authors.affiliation: Section of Dermatologic Surgery, Department of Oncology, University Hospital &quot;Città della Salute e della Scienza di Torino&quot;, Turin, Italy.
authors.forename: Eugenio
authors.initials: E
authors.lastname: Sportoletti Baduel
authors.affiliation: Section of Dermatology, Department of Medical Sciences, University of Turin, Turin, Italy.
authors.forename: Elena
authors.initials: E
authors.lastname: Marra
authors.affiliation: Section of Dermatologic Surgery, Department of Oncology, University Hospital &quot;Città della Salute e della Scienza di Torino&quot;, Turin, Italy.
authors.forename: Franco
authors.initials: F
authors.lastname: Picciotto
authors.affiliation: Section of Dermatologic Surgery, Department of Oncology, University Hospital &quot;Città della Salute e della Scienza di Torino&quot;, Turin, Italy.
authors.forename: Virginia
authors.initials: V
authors.lastname: Caliendo
authors.affiliation: Section of Dermatology, Department of Medical Sciences, University of Turin, Turin, Italy.
authors.forename: Maria T
authors.initials: MT
authors.lastname: Fierro
authors.affiliation: Section of Dermatology, Department of Medical Sciences, University of Turin, Turin, Italy.
authors.forename: Pietro
authors.initials: P
authors.lastname: Quaglino
mesh_terms: D006801:Humans; D008545:Melanoma / Q000175:diagnosis / Q000473:pathology*; D011379:Prognosis; D012878:Skin Neoplasms / Q000175:diagnosis / Q000473:pathology*