title: Deletion of 18q is a strong and independent prognostic feature in prostate cancer.
abstract: Deletion of 18q recurrently occurs in prostate cancer. To evaluate its clinical relevance, dual labeling fluorescence in-situ hybridization (FISH) using probes for 18q21 and centromere 18 was performed on a prostate cancer tissue microarray (TMA). An 18q deletion was found in 517 of 6,881 successfully analyzed cancers (7.5%). 18q deletion was linked to unfavorable tumor phenotype. An 18q deletion was seen in 6.4% of 4,360 pT2, 8.0% of 1,559 pT3a and 11.8% of 930 pT3b-pT4 cancers (P < 0.0001). Deletions of 18q were detected in 6.9% of 1,636 Gleason ≤ 3 + 3, 6.8% of 3,804 Gleason 3 + 4, 10.1% of 1,058 Gleason 4+3, and 9.9% of 344 Gleason ≥ 4 + 4 tumors (P = 0.0013). Deletions of 18q were slightly more frequent in ERG-fusion negative (8.2%) than in ERG-fusion positive cancers (6.4%, P = 0.0063). 18q deletions were also linked to biochemical recurrence (BCR, P < 0.0001). This was independent from established pre- and postoperative prognostic factors (P ≤ 0.0004). In summary, the results of our study identify 18q deletion as an independent prognostic parameter in prostate cancer. As it is easy to measure, 18q deletion may be a suitable component for multiparametric molecular prostate cancer prognosis tests.
authors.affiliation: Institute of Pathology, Prostate Cancer Center at University Medical Center Hamburg-Eppendorf, Germany.
authors.forename: Martina
authors.initials: M
authors.lastname: Kluth
authors.affiliation: Institute of Pathology, Prostate Cancer Center at University Medical Center Hamburg-Eppendorf, Germany.
authors.forename: Maximilian
authors.initials: M
authors.lastname: Graunke
authors.affiliation: Institute of Pathology, Prostate Cancer Center at University Medical Center Hamburg-Eppendorf, Germany.
authors.forename: Christina
authors.initials: C
authors.lastname: Möller-Koop
authors.affiliation: Institute of Pathology, Prostate Cancer Center at University Medical Center Hamburg-Eppendorf, Germany.
authors.forename: Claudia
authors.initials: C
authors.lastname: Hube-Magg
authors.affiliation: Institute of Pathology, Prostate Cancer Center at University Medical Center Hamburg-Eppendorf, Germany.
authors.forename: Sarah
authors.initials: S
authors.lastname: Minner
authors.affiliation: Martini-Clinic, Prostate Cancer Center at University Medical Center Hamburg-Eppendorf, Germany.
authors.forename: Uwe
authors.initials: U
authors.lastname: Michl
authors.affiliation: Martini-Clinic, Prostate Cancer Center at University Medical Center Hamburg-Eppendorf, Germany.
authors.forename: Markus
authors.initials: M
authors.lastname: Graefen
authors.affiliation: Martini-Clinic, Prostate Cancer Center at University Medical Center Hamburg-Eppendorf, Germany.
authors.forename: Hartwig
authors.initials: H
authors.lastname: Huland
authors.affiliation: Martini-Clinic, Prostate Cancer Center at University Medical Center Hamburg-Eppendorf, Germany.
authors.forename: Raisa
authors.initials: R
authors.lastname: Pompe
authors.affiliation: Institute of Pathology, Prostate Cancer Center at University Medical Center Hamburg-Eppendorf, Germany.
authors.forename: Frank
authors.initials: F
authors.lastname: Jacobsen
authors.affiliation: Institute of Pathology, Prostate Cancer Center at University Medical Center Hamburg-Eppendorf, Germany.
authors.forename: Andrea
authors.initials: A
authors.lastname: Hinsch
authors.affiliation: Institute of Pathology, Prostate Cancer Center at University Medical Center Hamburg-Eppendorf, Germany.
authors.forename: Corinna
authors.initials: C
authors.lastname: Wittmer
authors.affiliation: Institute of Pathology, Prostate Cancer Center at University Medical Center Hamburg-Eppendorf, Germany.
authors.forename: Patrick
authors.initials: P
authors.lastname: Lebok
authors.affiliation: Institute of Pathology, Prostate Cancer Center at University Medical Center Hamburg-Eppendorf, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Steurer
authors.affiliation: Institute of Pathology, Prostate Cancer Center at University Medical Center Hamburg-Eppendorf, Germany.
authors.forename: Franziska
authors.initials: F
authors.lastname: Büscheck
authors.affiliation: Institute of Pathology, Prostate Cancer Center at University Medical Center Hamburg-Eppendorf, Germany.
authors.forename: Till
authors.initials: T
authors.lastname: Clauditz
authors.affiliation: Institute of Pathology, Prostate Cancer Center at University Medical Center Hamburg-Eppendorf, Germany.
authors.forename: Waldemar
authors.initials: W
authors.lastname: Wilczak
authors.affiliation: Institute of Pathology, Prostate Cancer Center at University Medical Center Hamburg-Eppendorf, Germany.
authors.forename: Guido
authors.initials: G
authors.lastname: Sauter
authors.affiliation: Martini-Clinic, Prostate Cancer Center at University Medical Center Hamburg-Eppendorf, Germany.|Department of Urology, Section for prostate cancer research, University Medical Center Hamburg-Eppendorf, Germany.
authors.forename: Thorsten
authors.initials: T
authors.lastname: Schlomm
authors.affiliation: Institute of Pathology, Prostate Cancer Center at University Medical Center Hamburg-Eppendorf, Germany.
authors.forename: Ronald
authors.initials: R
authors.lastname: Simon
mesh_terms: D000328:Adult; D000368:Aged; D002872:Chromosome Deletion; D002887:Chromosomes, Human, Pair 18; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D000071230:Transcriptional Regulator ERG / Q000235:genetics
chemical_list: C072312:ERG protein, human; D000071230:Transcriptional Regulator ERG; D017430:Prostate-Specific Antigen
keywords: 18q deletion; prognosis; prostate cancer; tissue microarray