title: The XIIIth Banff Conference on Allograft Pathology: The Banff 2015 Heart Meeting Report: Improving Antibody-Mediated Rejection Diagnostics: Strengths, Unmet Needs, and Future Directions.
abstract: The 13th Banff Conference on Allograft Pathology was held in Vancouver, British Columbia, Canada from October 5 to 10, 2015. The cardiac session was devoted to current diagnostic issues in heart transplantation with a focus on antibody-mediated rejection (AMR) and small vessel arteriopathy. Specific topics included the strengths and limitations of the current rejection grading system, the central role of microvascular injury in AMR and approaches to semiquantitative assessment of histopathologic and immunophenotypic indicators, the role of AMR in the development of cardiac allograft vasculopathy, the important role of serologic antibody detection in the management of transplant recipients, and the potential application of new molecular approaches to the elucidation of the pathophysiology of AMR and potential for improving the current diagnostic system. Herein we summarize the key points from the presentations, the comprehensive, open and wide-ranging multidisciplinary discussion that was generated, and considerations for future endeavors.
authors.affiliation: Paris Translational Research Center for Organ Transplantation & Department of Pathology, Hôpital Européen Georges Pompidou, Université Paris Descartes Médecine, Paris, France.
authors.forename: P
authors.initials: P
authors.lastname: Bruneval
authors.affiliation: Department of Cardiac Thoracic and Vascular Sciences, University of Padua Medical School, Padua, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Angelini
authors.affiliation: Intermountain Medical Center, University of Utah, Salt Lake City, UT.
authors.forename: D
authors.initials: D
authors.lastname: Miller
authors.affiliation: Heart and Lung Transplant Program, University of Bologna, Academic Hospital S, Orsola-Malpighi, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Potena
authors.affiliation: Paris Translational Research Center for Organ Transplantation INSERM U970, Necker Hospital University Paris Descartes, Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Loupy
authors.affiliation: University of Pittsburgh Medical Center, Pittsburgh, PA.
authors.forename: A
authors.initials: A
authors.lastname: Zeevi
authors.affiliation: Department of Pathology and Laboratory Medicine, University of California, Los Angeles, CA.
authors.forename: E F
authors.initials: EF
authors.lastname: Reed
authors.affiliation: Berlin Institute of Health and Department of Nephrology and Critical Care Medicine, Charité Universitätsmedizin, Berlin, Germany.
authors.forename: D
authors.initials: D
authors.lastname: Dragun
authors.affiliation: Cedars-Sinai Medical Center, Los Angeles, CA.
authors.forename: N
authors.initials: N
authors.lastname: Reinsmoen
authors.affiliation: Pathology Department, Massachusetts General Hospital, Boston, MA.
authors.forename: R N
authors.initials: RN
authors.lastname: Smith
authors.affiliation: Alberta Transplant Institute and University of Alberta, Edmonton, Canada.
authors.forename: L
authors.initials: L
authors.lastname: West
authors.affiliation: Centre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, BC, Canada.
authors.forename: S
authors.initials: S
authors.lastname: Tebutt
authors.affiliation: IFB, Molecular and Translational Therapeutic Strategies, Hannover Medical School, Hannover, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Thum
authors.affiliation: Department of Pathology & Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA.
authors.forename: M
authors.initials: M
authors.lastname: Haas
authors.affiliation: Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Canada.
authors.forename: M
authors.initials: M
authors.lastname: Mengel
authors.affiliation: Intermountain Medical Center, University of Utah, Salt Lake City, UT.
authors.forename: P
authors.initials: P
authors.lastname: Revelo
authors.affiliation: Department of Cardiac Thoracic and Vascular Sciences, University of Padua Medical School, Padua, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Fedrigo
authors.affiliation: Paris Translational Research Center for Organ Transplantation INSERM U970, Necker Hospital University Paris Descartes, Paris, France.
authors.forename: J P
authors.initials: JP
authors.lastname: Duong Van Huyen
authors.affiliation: Department of Pathology, Stanford University, Stanford, CA.
authors.forename: G J
authors.initials: GJ
authors.lastname: Berry
mesh_terms: D006084:Graft Rejection / Q000209:etiology / Q000473:pathology*; D006801:Humans; D007518:Isoantibodies / Q000097:blood / Q000276:immunology*; D016377:Organ Transplantation / Q000009:adverse effects*; D017410:Practice Guidelines as Topic / Q000592:standards*; D058028:Research Report; D014184:Transplantation, Homologous
chemical_list: D007518:Isoantibodies
keywords: clinical research/practice; heart transplantation/cardiology; rejection; rejection: antibody-mediated (ABMR); rejection: subclinical; translational research/science