title: New mono-ether of glycerol and triterpenes with DPPH radical scavenging activity from Cameroonian propolis.
abstract: The extracts of some propolis samples were analysed by GC-MS and then purified by column chromatography. The latter led to the isolation of a new mono-ether of glycerol, 1'-O-eicosanyl glycerol and a new triterpene, methyl-3β,27-dihydroxycycloart-24-en-26-oate together with known triterpenoids namely betulin, 3β-hydroxylanostan-9,24-dien-21-oic acid, mangiferonic acid, a mixture of ambolic acid and β-sitosterol, 3β-hydroxycycloartan-12,24(25)-diene and 27-hydroxymangiferonic acid. The DPPH radical scavenging potential of some extracts and compounds were measured. The radical scavenging activity varied from Hexane extract of Foumban propolis (IC50= 5.6 mg/mL) to Methanol extract of Foumban propolis (IC50= 1.07 mg/mL) for the extracts and from 3β-hydroxylanostan-9,24-dien-21-oic acid (IC50= 1.22 mg/mL) to 1'-O-eicosanyl glycerol (IC50= 0.93 mg/mL) for the compounds. Activities of samples were moderate as they remained closer to those of the standard antioxidants Gallic acid (IC50= 0.30 mg/mL) and vitamin C (IC50= 0.80 mg/mL), especially 1'-O-eicosanyl glycerol, the most active compound.
authors.affiliation: b Faculty of Science, Department of Chemistry , University of Ngaoundéré , Ngaoundéré , Cameroon.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Talla
authors.affiliation: a Faculty of Science, Department of Organic Chemistry , University of Yaoundé I , Yaoundé , Cameroon.
authors.forename: Alfred Ngenge
authors.initials: AN
authors.lastname: Tamfu
authors.affiliation: b Faculty of Science, Department of Chemistry , University of Ngaoundéré , Ngaoundéré , Cameroon.
authors.forename: Isaac Sylvère
authors.initials: IS
authors.lastname: Gade
authors.affiliation: b Faculty of Science, Department of Chemistry , University of Ngaoundéré , Ngaoundéré , Cameroon.
authors.forename: Lambert
authors.initials: L
authors.lastname: Yanda
authors.affiliation: a Faculty of Science, Department of Organic Chemistry , University of Yaoundé I , Yaoundé , Cameroon.
authors.forename: Joseph Tanyi
authors.initials: JT
authors.lastname: Mbafor
authors.affiliation: c Faculty of Medicine and Pharmacy, Department of General, Organic and Biomedical Chemistry , University of Mons, NMR and Molecular Imaging Laboratory , Mons , Belgium.
authors.forename: Sophie
authors.initials: S
authors.lastname: Laurent
authors.affiliation: c Faculty of Medicine and Pharmacy, Department of General, Organic and Biomedical Chemistry , University of Mons, NMR and Molecular Imaging Laboratory , Mons , Belgium.
authors.forename: Luce Vander
authors.initials: LV
authors.lastname: Elst
authors.affiliation: d Institute of Organic Chemistry with Centre of Phytochemistry , Bulgarian Academy of Sciences , Sofia , Bulgaria.
authors.forename: Milena
authors.initials: M
authors.lastname: Popova
authors.affiliation: d Institute of Organic Chemistry with Centre of Phytochemistry , Bulgarian Academy of Sciences , Sofia , Bulgaria.
authors.forename: Vassya
authors.initials: V
authors.lastname: Bankova
mesh_terms: D016166:Free Radical Scavengers / Q000302:isolation & purification*; D005990:Glycerol / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D011429:Propolis / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D016166:Free Radical Scavengers; D014315:Triterpenes; D011429:Propolis; D005990:Glycerol
keywords: 1′-O-eicosanyl glycerol; DPPH· radical scavenging activity; GC-MS profiles; NMR analysis; Propolis; triterpenes