title: Cytological findings and BCL10 expression in pancreatic acinar cell carcinoma: A Case Report.
abstract: BCL10 was recently demonstrated to be a biomarker for pancreatic acinar cell carcinoma, but whether altered BCL10 expression can be detected in cell block specimens is unclear. Here, we report a pancreatic acinar cell carcinoma with cytological findings that showed BCL10 expression in a cell block. A 72-year-old man presented with a pancreatic tumor and underwent endoscopic ultrasound-fine needle aspiration (EUS-FNA) with additional passes performed for cell block preparation. The EUS-FNA cytology showed loose cohesive clusters with focal acinar- or gland-like-structures and prominent nucleoli. The preoperative diagnosis was well differentiated adenocarcinoma, and he underwent a pancreaticoduodenectomy. Histological examination revealed an acinar tumor structure with tumor cells staining positive for BCL10 and trypsin. The cell block specimen also demonstrated strong and diffuse BCL10-positive staining. Based on these findings, this tumor was diagnosed as acinar cell carcinoma of the pancreas. This case demonstrates that BCL10 expression within cell blocks facilitates a differential diagnosis of acinar cell carcinoma. Diagn. Cytopathol. 2017;45:247-251. © 2016 Wiley Periodicals, Inc.
authors.affiliation: Division of Pathology, University of Miyazaki Hospital, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
authors.forename: Akinobu
authors.initials: A
authors.lastname: Ohno
authors.affiliation: Division of Pathology, University of Miyazaki Hospital, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.|Department of Diagnostic Pathology, University of Miyazaki Hospital, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Sato
authors.affiliation: Department of Diagnostic Pathology, University of Miyazaki Hospital, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.|Department of Pathology, University of Miyazaki, Miyazaki, Japan, Faculty of Medicine, Miyazaki, Japan.
authors.forename: Eriko
authors.initials: E
authors.lastname: Nakamura
authors.affiliation: Division of Pathology, University of Miyazaki Hospital, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Noguchi
authors.affiliation: Division of Pathology, University of Miyazaki Hospital, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
authors.forename: Takako
authors.initials: T
authors.lastname: Tokumitsu
authors.affiliation: Division of Hepato-Biliary-Pancreas Surgery, Department of Surgery, University of Miyazaki, Miyazaki, Japan, Faculty of Medicine, Miyazaki, Japan.
authors.forename: Masahide
authors.initials: M
authors.lastname: Hiyoshi
authors.affiliation: Division of Hepato-Biliary-Pancreas Surgery, Department of Surgery, University of Miyazaki, Miyazaki, Japan, Faculty of Medicine, Miyazaki, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Nanashima
authors.affiliation: Department of Diagnostic Pathology, University of Miyazaki Hospital, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.|Department of Pathology, University of Miyazaki, Miyazaki, Japan, Faculty of Medicine, Miyazaki, Japan.
authors.forename: Yujiro
authors.initials: Y
authors.lastname: Asada
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism*; D000368:Aged; D000074018:B-Cell CLL-Lymphoma 10 Protein; D018267:Carcinoma, Acinar Cell / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008297:Male; D010179:Pancreas / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D000074018:B-Cell CLL-Lymphoma 10 Protein; C118591:BCL10 protein, human
keywords: BCL10; acinar cell carcinoma; cell block; endoscopic ultrasound-fine needle aspiration; pancreas