title: Influence of surfactants on depsipeptide submicron particle formation.
abstract: Surfactants are required for the formation and stabilization of hydrophobic polymeric particles in aqueous environment. In order to form submicron particles of varying sizes from oligo[3-(S)-sec-butylmorpholine-2,5-dione]diols ((OBMD)-diol), different surfactants were investigated. As new surfactants, four-armed star-shaped oligo(ethylene glycol)s of molecular weights of 5-20kDa functionalized with desamino-tyrosine (sOEG-DAT) resulted in smaller particles with lower PDI than with desaminotyrosyl tyrosine (sOEG-DATT) in an emulsion/solvent evaporation method. In a second set of experiments, sOEG-DAT of Mn=10kDa was compared with the commonly employed emulsifiers polyvinylalcohol (PVA), polyoxyethylene (20) sorbitan monolaurate (Tween 20), and D-α-tocopherol polyethylene glycol succinate (VIT E-TPGS) for OBMD particle preparation. sOEG-DAT allowed to systematically change sizes in a range of 300 up to 900nm with narrow polydispersity, while in the other cases, a lower size range (250-400nm, PVA; ∼300nm, Tween 20) or no effective particle formation was observed. The ability of tailoring particle size in a broad range makes sOEG-DAT of particular interest for the formation of oligodepsipeptide particles, which can further be investigated as drug carriers for controlled delivery.
authors.affiliation: Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany; Institute of Chemistry, University of Potsdam, Potsdam, Germany.
authors.forename: Nadia
authors.initials: N
authors.lastname: Brunacci
authors.affiliation: Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Wischke
authors.affiliation: Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany.
authors.forename: Toufik
authors.initials: T
authors.lastname: Naolou
authors.affiliation: Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany; Institute of Chemistry, University of Potsdam, Potsdam, Germany. Electronic address: axel.neffe@hzg.de.
authors.forename: Axel T
authors.initials: AT
authors.lastname: Neffe
authors.affiliation: Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany; Institute of Chemistry, University of Potsdam, Potsdam, Germany. Electronic address: andreas.lendlein@hzg.de.
authors.forename: Andreas
authors.initials: A
authors.lastname: Lendlein
mesh_terms: D047630:Depsipeptides / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry; D045703:Emulsifying Agents / Q000737:chemistry; D004655:Emulsions / Q000737:chemistry; D008970:Molecular Weight; D053758:Nanoparticles / Q000737:chemistry; D010316:Particle Size; D011092:Polyethylene Glycols / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D011136:Polysorbates / Q000737:chemistry; D011142:Polyvinyl Alcohol / Q000737:chemistry; D012997:Solvents / Q000737:chemistry; D013501:Surface-Active Agents / Q000737:chemistry*; D014443:Tyrosine / Q000737:chemistry; D024502:alpha-Tocopherol / Q000031:analogs & derivatives / Q000737:chemistry
chemical_list: D047630:Depsipeptides; D004337:Drug Carriers; D045703:Emulsifying Agents; D004655:Emulsions; D011108:Polymers; D011136:Polysorbates; D012997:Solvents; D013501:Surface-Active Agents; D011092:Polyethylene Glycols; D014443:Tyrosine; D011142:Polyvinyl Alcohol; D024502:alpha-Tocopherol
keywords: Depsipeptide; Particle size; Submicron particles; Surfactants