title: Biofabrication of polyphenols stabilized reduced graphene oxide and its anti-tuberculosis activity.
abstract: A facile one step eco-friendly method for the reduction graphene oxide by Cinnamomumverum (C. verum) bark extract is reported in this work. This approach avoids the utilization of hazardous chemical reagents. The characterization results of various spectroscopic and microscopic techniques for the prepared graphene oxide (GO) and reduced graphene oxide (RGO) afford a strong indication of the removal of oxygen functionalities of GO after reduction and following stabilization by the oxidised polyphenols. Fourier transform infrared spectral results showed the capping of oxidised polyphenols onto the surface of reduced graphene oxide which further prevent their aggregation. Additionally, the prepared graphene nanosheets were tested for their antituberculosis activity against standard strain such as M. tuberculosis H37Ra. The obtained results suggested that the synthesized graphene acts as an effective growth inhibitors against M. tuberculosis H37Ra making it applicable for targeted drug delivery by combining with other chemical drugs as a therapeutic index.
authors.affiliation: Department II of Tuberculosis Medicine, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan 453100, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Han
authors.affiliation: Department IV of Tuberculosis Medicine, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan 453100, China.
authors.forename: Wen-Yi
authors.initials: WY
authors.lastname: Niu
authors.affiliation: Department II of Tuberculosis Medicine, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan 453100, China.
authors.forename: Bing
authors.initials: B
authors.lastname: Sun
authors.affiliation: Department III of Tuberculosis Medicine, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan 453100, China.
authors.forename: Guang-Can
authors.initials: GC
authors.lastname: Shi
authors.affiliation: Department II of Tuberculosis Medicine, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan 453100, China. Electronic address: cuixiuqin123@hotmail.com.
authors.forename: Xiu-Qin
authors.initials: XQ
authors.lastname: Cui
mesh_terms: D000995:Antitubercular Agents / Q000737:chemistry*; D006108:Graphite / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission; D010087:Oxides / Q000737:chemistry*; D059808:Polyphenols / Q000737:chemistry*
chemical_list: D000995:Antitubercular Agents; D010087:Oxides; D059808:Polyphenols; D006108:Graphite
keywords: Oxidised polyphenols; Reduced graphene oxide; Tuberculosis