title: Sexually Dimorphic Expression of Reelin in the Brain of a Mouse Model of Alzheimer Disease.
abstract: Recent evidence highlights the protective role of reelin against amyloid β (Aβ)-induced synaptic dysfunction and cognitive impairment in Alzheimer disease (AD). In this study, exploiting TgCRND8 mice that overexpress a mutant form of amyloid β precursor protein (AβPP) and display an early onset of AD neuropathological signs, we addressed the question whether changes of reelin expression eventually precede the appearance of Aβ-plaques in a sex-dependent manner. We show that sex-associated and brain region-specific differences in reelin expression appear long before Aβ-plaque formation. However, in spite of a downregulation of reelin expression compared to males, TgCRND8 females display fewer Aβ-plaques, suggesting that additional factors, other than sex and reelin level, influence amyloidosis in this mouse model.
authors.affiliation: Department of Psychology, Section of Neuroscience and "Daniel Bovet" Neurobiology Research Center, Sapienza University of Rome, 00185, Rome, Italy.
authors.forename: Giampiero
authors.initials: G
authors.lastname: Palladino
authors.affiliation: Department of Surgery "P. Valdoni", Sapienza University of Rome, 00185, Rome, Italy.
authors.forename: Vincenzina
authors.initials: V
authors.lastname: Nicolia
authors.affiliation: Institute of Neurology Medical University of Vienna, Vienna, Austria.
authors.forename: Gabor G
authors.initials: GG
authors.lastname: Kovacs
authors.affiliation: Department of Psychology, Section of Neuroscience and "Daniel Bovet" Neurobiology Research Center, Sapienza University of Rome, 00185, Rome, Italy.
authors.forename: Sonia
authors.initials: S
authors.lastname: Canterini
authors.affiliation: Department of Surgery "P. Valdoni", Sapienza University of Rome, 00185, Rome, Italy.
authors.forename: Viviana
authors.initials: V
authors.lastname: Ciraci
authors.affiliation: Department of Psychology, Section of Neuroscience and "Daniel Bovet" Neurobiology Research Center, Sapienza University of Rome, 00185, Rome, Italy.|European Center for Brain Research (CERC)/IRCCS Santa Lucia Foundation, Via del Fosso di Fiorano 64-65, 00143, Rome, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Fuso
authors.affiliation: Department of Psychology, Section of Neuroscience and "Daniel Bovet" Neurobiology Research Center, Sapienza University of Rome, 00185, Rome, Italy.
authors.forename: Franco
authors.initials: F
authors.lastname: Mangia
authors.affiliation: Department of Surgery "P. Valdoni", Sapienza University of Rome, 00185, Rome, Italy.
authors.forename: Sigfrido
authors.initials: S
authors.lastname: Scarpa
authors.affiliation: Department of Psychology, Section of Neuroscience and "Daniel Bovet" Neurobiology Research Center, Sapienza University of Rome, 00185, Rome, Italy. mariateresa.fiorenza@uniroma1.it.
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Fiorenza
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics / Q000378:metabolism*; D016564:Amyloid beta-Protein Precursor / Q000235:genetics; D000818:Animals; D001921:Brain / Q000378:metabolism*; D015816:Cell Adhesion Molecules, Neuronal / Q000235:genetics / Q000378:metabolism*; D015536:Down-Regulation; D016326:Extracellular Matrix Proteins / Q000235:genetics / Q000378:metabolism*; D005260:Female; D008297:Male; D051379:Mice; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism*; D009928:Organ Specificity; D000091042:Reelin Protein; D012697:Serine Endopeptidases / Q000235:genetics / Q000378:metabolism*; D012737:Sex Factors
chemical_list: D016564:Amyloid beta-Protein Precursor; D015816:Cell Adhesion Molecules, Neuronal; D016326:Extracellular Matrix Proteins; D009419:Nerve Tissue Proteins; D000091042:Reelin Protein; C000717128:Reln protein, mouse; D012697:Serine Endopeptidases
keywords: Aβ-plaques; Mouse models of AD; Sex-influenced gene expression patterns; TgCRND8