title: Quantitative T2 mapping for detection and quantification of thrombophlebitis in a rabbit model.
abstract: Short peripheral catheter thrombophlebitis (SPCT), a sterile inflammation of the vein wall, is the most common complication associated with short peripheral catheters (SPCs) and affects up to 80% of hospitalized patients receiving IV therapy. Extensive research efforts have been devoted for improvement and optimization of the catheter material, but means for examination of any novel design are limited, inaccurate and require costly comprehensive pre-clinical and clinical trials. Therefore, there is a conclusive need for a reliable quantitative method for evaluation of SPCT, in particular for research purposes examining the thrombophlebitis-related symptoms of any novel catheter design. In this study, we developed for the first time a quantitative MRI based tool for evaluation of SPCT. The extent and severity of SPCT caused by two different commercially available SPCs with known predisposition for thrombophlebitis, were studied in a rabbit model. MRI analysis was consistent with the standardized pathology evaluation and showed remarkable difference in the percent of edema between the experimental groups. These differences were in line with previous studies and provide evidence that this type of analysis may be useful for future assessment of SPCT in vivo. As a non-invasive method, it may constitute a cost effective solution for examination of new catheters and other medical devices, thereby reducing the need for animal sacrifice.
authors.affiliation: Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv 69978, Israel. Electronic address: darweiss@gmail.com.
authors.forename: Dar
authors.initials: D
authors.lastname: Weiss
authors.affiliation: Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY 11794, USA.
authors.forename: Oren M
authors.initials: OM
authors.lastname: Rotman
authors.affiliation: Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv 69978, Israel; Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY 11794, USA.
authors.forename: Shmuel
authors.initials: S
authors.lastname: Einav
mesh_terms: D000818:Animals; D002406:Catheterization, Peripheral / Q000009:adverse effects*; D057785:Catheters / Q000009:adverse effects; D004195:Disease Models, Animal; D005260:Female; D008279:Magnetic Resonance Imaging; D011817:Rabbits; D013924:Thrombophlebitis / Q000000981:diagnostic imaging* / Q000209:etiology* / Q000473:pathology; D014680:Veins / Q000000981:diagnostic imaging* / Q000473:pathology
keywords: Edema; Inflammation; MRI; Peripheral catheter; Thrombophlebitis