title: Convergence of The Nobel Fields of Telomere Biology and DNA Repair.
abstract: The fields of telomere biology and DNA repair have enjoyed a great deal of cross-fertilization and convergence in recent years. Telomeres function at chromosome ends to prevent them from being falsely recognized as chromosome breaks by the DNA damage response and repair machineries. Conversely, both canonical and nonconical functions of numerous DNA repair proteins have been found to be critical for preserving telomere structure and function. In 2009, Elizabeth Blackburn, Carol Greider and Jack Szostak were awarded the Nobel prize in Physiology or Medicine for the discovery of telomeres and telomerase. Four years later, pioneers in the field of DNA repair, Aziz Sancar, Tomas Lindahl and Paul Modrich were recognized for their seminal contributions by being awarded the Nobel Prize in Chemistry. This review is part of a special issue meant to celebrate this amazing achievement, and will focus in particular on the convergence of nucleotide excision repair and telomere biology, and will discuss the profound implications for human health.
authors.affiliation: Department of Environmental and Occupational Health, University of Pittsburgh Graduate School of Public Health, University of Pittsburgh Cancer Institute Research Pavilion, University of Pittsburgh, Pittsburgh, PA.
authors.forename: Elise
authors.initials: E
authors.lastname: Fouquerel
authors.affiliation: Department of Environmental and Occupational Health, University of Pittsburgh Graduate School of Public Health, University of Pittsburgh Cancer Institute Research Pavilion, University of Pittsburgh, Pittsburgh, PA.
authors.forename: Patricia L
authors.identifier: 0000-0002-6470-2189
authors.initials: PL
authors.lastname: Opresko
mesh_terms: D002869:Chromosome Aberrations; D004249:DNA Damage; D004260:DNA Repair; D004255:Deoxyribodipyrimidine Photo-Lyase / Q000378:metabolism; D006801:Humans; D009613:Nobel Prize; D011740:Pyrimidine Dimers / Q000378:metabolism; D019098:Telomerase / Q000378:metabolism; D016615:Telomere; D014466:Ultraviolet Rays
chemical_list: D011740:Pyrimidine Dimers; D019098:Telomerase; C098727:pyrimidine(6-4)pyrimidone photolyase; D004255:Deoxyribodipyrimidine Photo-Lyase