title: The effects of olanzapine treatment on brain regional glucose metabolism in neuroleptic-naive first-episode schizophrenic patients.
abstract: The current study examined metabolic alterations associated with a positive response to olanzapine and identified brain regions associated with treatment-related improvement of symptoms in neuroleptic-naive first-episode schizophrenic patients using [18F]fluoro-deoxy-glucose positron emission tomography analysis.
  
  
  
  Neuroleptic-naive first-episode schizophrenic patients who showed good or poor clinical responses to olanzapine were assessed using the Positive and Negative Syndrome Scale. Data were analyzed using statistical nonparametric mapping.
  
  
  
  Before treatment, responders showed significantly increased metabolism in the superior temporal gyrus and cerebellum compared with healthy controls. Glucose metabolism in responders was significantly increased after treatment in the left precentral gyrus, left postcentral gyrus, and left paracentral lobule, and significantly decreased in the left hypothalamus. An analysis of the Positive and Negative Syndrome Scale symptoms associated with olanzapine treatment revealed that "suspiciousness/persecution" scores were positively correlated with metabolic changes in the right superior frontal gyrus.
  
  
  
  These findings provide evidence of the neural mechanisms underlying the effects of olanzapine on metabolism in the early stages of schizophrenia.
authors.affiliation: Department of Psychiatry, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.|Fujimoto Hospital, Fujimoto Medical System, Japan.
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Yoshimuta
authors.affiliation: Department of Psychiatry, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Nakamura
authors.affiliation: Department of Psychiatry, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.|Fujimoto Hospital, Fujimoto Medical System, Japan.
authors.forename: Eisuke
authors.initials: E
authors.lastname: Kanda
authors.affiliation: Fujimoto General Hospital, Fujimoto Medical System, Japan.
authors.forename: Seigo
authors.initials: S
authors.lastname: Fujita
authors.affiliation: Fujimoto Hospital, Fujimoto Medical System, Japan.
authors.forename: Kouzou
authors.initials: K
authors.lastname: Takeuchi
authors.affiliation: Fujimoto Hospital, Fujimoto Medical System, Japan.|Fujimoto General Hospital, Fujimoto Medical System, Japan.
authors.forename: Toshiro
authors.initials: T
authors.lastname: Fujimoto
authors.affiliation: Department of Radiology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Nakabeppu
authors.affiliation: Department of Psychiatry, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.|Department of Clinical Occupational Therapy, School of Health Sciences, Faculty of Medicine, Kagoshima University, Kagoshima, Japan.
authors.forename: Yasuaki
authors.initials: Y
authors.lastname: Akasaki
authors.affiliation: Department of Psychiatry, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Sano
mesh_terms: D000293:Adolescent; D000328:Adult; D014150:Antipsychotic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001569:Benzodiazepines / Q000494:pharmacology / Q000627:therapeutic use*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D016022:Case-Control Studies; D005260:Female; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D008297:Male; D000077152:Olanzapine; D049268:Positron-Emission Tomography; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000188:drug therapy* / Q000503:physiopathology; D012720:Severity of Illness Index; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D014150:Antipsychotic Agents; D001569:Benzodiazepines; D005947:Glucose; D000077152:Olanzapine
keywords: PANSS; first-episode schizophrenia; fluoro-deoxy-glucose positron emission tomography; olanzapine; treatment response