title: Molecular Imaging and Precision Medicine in Head and Neck Cancer.
abstract: The concept of using tumor genomic profiling information has revolutionized personalized cancer treatment. Head and neck (HN) cancer management is being influenced by recent discoveries of activating mutations in epidermal growth factor receptor and related targeted therapies with tyrosine kinase inhibitors, targeted therapies for Kristen Rat Sarcoma, and MET proto-oncogenes. Molecular imaging using PET plays an important role in assessing the biologic behavior of HN cancer with the goal of delivering individualized cancer treatment. This review summarizes recent genomic discoveries in HN cancer and their implications for functional PET imaging in assessing response to targeted therapies, and drug resistance mechanisms.
authors.affiliation: Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins School of Medicine, Johns Hopkins University, 601 North Caroline Street, Baltimore, MD 21287, USA.
authors.forename: Esther
authors.initials: E
authors.lastname: Mena
authors.affiliation: Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins School of Medicine, Johns Hopkins University, 601 North Caroline Street, Baltimore, MD 21287, USA.
authors.forename: Shwetha
authors.initials: S
authors.lastname: Thippsandra
authors.affiliation: Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins School of Medicine, Johns Hopkins University, 601 North Caroline Street, Baltimore, MD 21287, USA.
authors.forename: Anusha
authors.initials: A
authors.lastname: Yanamadala
authors.affiliation: Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins School of Medicine, Johns Hopkins University, 601 North Caroline Street, Baltimore, MD 21287, USA.
authors.forename: Siddaling
authors.initials: S
authors.lastname: Redy
authors.affiliation: Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins School of Medicine, Johns Hopkins University, 601 North Caroline Street, Baltimore, MD 21287, USA.
authors.forename: Puskar
authors.initials: P
authors.lastname: Pattanayak
authors.affiliation: Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins School of Medicine, Johns Hopkins University, 601 North Caroline Street, Baltimore, MD 21287, USA; Department of Radiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-8896, USA; Department of Clinical Sciences, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9096, USA; Department of Biomedical Engineering, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX, 75390-8896, USA; Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX, 75390-8896, USA. Electronic address: rathan.subramaniam@UTsouthwestern.edu.
authors.forename: Rathan M
authors.initials: RM
authors.lastname: Subramaniam
mesh_terms: D014408:Biomarkers, Tumor; D019008:Drug Resistance, Neoplasm; D019788:Fluorodeoxyglucose F18; D023281:Genomics; D006258:Head and Neck Neoplasms / Q000000981:diagnostic imaging* / Q000235:genetics / Q000628:therapy*; D006801:Humans; D057054:Molecular Imaging; D058990:Molecular Targeted Therapy; D000072078:Positron Emission Tomography Computed Tomography; D049268:Positron-Emission Tomography; D057285:Precision Medicine; D011379:Prognosis; D019275:Radiopharmaceuticals
chemical_list: D014408:Biomarkers, Tumor; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
keywords: Head and neck cancer; Molecular imaging; Targeted therapy; Tumor genetic profiling