title: Biomonitoring of 29 trace elements in whole blood from inhabitants of Cotonou (Benin) by ICP-MS.
abstract: This study aimed to investigate the blood concentration of 29 trace elements, metals or metalloids, in a healthy population of Cotonou not directly exposed to metals in order to propose reference values. Blood samples from 70 blood donors were collected in K2 EDTA tubes for trace elements during September 2015 and a questionnaire was used to assess lifestyle exposure. Blood metal concentrations were determined by inductively coupled plasma mass spectrometry (ICP-MS) equipped with a quadrupole-based reaction cell. Among the selected blood donors 51.4% were aged from 18 to 36 years and 49.6% from 37 to 65 years. Among the 29 elements analyzed As, Pb, Mn, Pd, Sb, Co, Se, Sr showed blood concentrations higher than the reference values found in the literature for non-exposed healthy European populations and their geometric means were respectively 5.81; 47.39; 19.71; 1.91; 7.50; 0.66; 163.01; 30.53μg/L. This study provides the first reference value (5th-95th percentiles) for each element in Cotonou, which enables us to carry out further investigations on environmental and occupational exposure.
authors.affiliation: INSERM, U1094, Tropical Neuroepidemiology, Limoges, France; Unit of Teaching and Research in Occupational and Environmental Health, University of Abomey-Calavi, 01 BP 188 Cotonou, Benin. Electronic address: briceyedomon@yahoo.fr.
authors.forename: Brice
authors.initials: B
authors.lastname: Yedomon
authors.affiliation: University hospital of Limoges, Department of Pharmacology and Toxicology, F-87000 Limoges, France. Electronic address: alain.menudier@unilim.fr.
authors.forename: Alain
authors.initials: A
authors.lastname: Menudier
authors.affiliation: University hospital of Limoges, Department of Pharmacology and Toxicology, F-87000 Limoges, France. Electronic address: Florence.LECAVELIER@chu-limoges.fr.
authors.forename: Florence Lecavelier Des
authors.initials: FLD
authors.lastname: Etangs
authors.affiliation: National Agency for Blood Transfusion of Benin, BP 386 Cotonou, Benin. Electronic address: ananily2002@yahoo.fr.
authors.forename: Ludovic
authors.initials: L
authors.lastname: Anani
authors.affiliation: Unit of Teaching and Research in Occupational and Environmental Health, University of Abomey-Calavi, 01 BP 188 Cotonou, Benin. Electronic address: bfayomi2@yahoo.fr.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Fayomi
authors.affiliation: INSERM, U1094, Tropical Neuroepidemiology, Limoges, France. Electronic address: michel.druet-cabanac@unilim.fr.
authors.forename: Michel
authors.initials: M
authors.lastname: Druet-Cabanac
authors.affiliation: INSERM, U1094, Tropical Neuroepidemiology, Limoges, France; University hospital of Limoges, Department of Pharmacology and Toxicology, F-87000 Limoges, France. Electronic address: christian.moesch@unilim.fr.
authors.forename: Christian
authors.initials: C
authors.lastname: Moesch
mesh_terms: D000293:Adolescent; D000328:Adult; D001541:Benin; D004784:Environmental Monitoring / Q000379:methods*; D005060:Europe; D005260:Female; D006801:Humans; D008297:Male; D013058:Mass Spectrometry / Q000379:methods*; D014131:Trace Elements / Q000097:blood*; D055815:Young Adult
chemical_list: D014131:Trace Elements
keywords: Benin; Biomonitoring; Blood donors; ICP-MS; Trace elements; Whole blood