title: The prognostic value of T Lymphoma Invasion and Metastasis 1 (TIAM1) expression in oral squamous cell carcinoma.
abstract: Oral squamous cell carcinoma (OSCC) is the most common malignant neoplasm with high rate of lymph node metastasis and recurrence. The aim of this study is to evaluate the expression profile of T Lymphoma Invasion and Metastasis 1 (TIAM1) in OSCC and its correlation with clinical outcomes including lymph node metastasis and recurrence. Detection of TIAM1 expression in tumor samples from 56 OSCC patients and oral mucosa samples from 20 healthy people was performed by immunohistochemistry. Then immunostaining score of each patient was calculated. The results revealed that TIAM1 was aberrantly expressed in the OSCC group compared with the normal group. Furthermore, high expression of TIAM1 was significantly correlated with lymph node metastasis and the timing of recurrence. Assessment of TIAM1 expression might represent a valid tool in clinical practice for prediction of metastasis, recurrence, and prognosis of OSCC.
authors.affiliation: Department of Stomatology, Beijing YouAn Hospital, Capital Medical University, Beijing, 100069, People's Republic of China.
authors.forename: Lu
authors.initials: L
authors.lastname: Lin
authors.affiliation: Department of Stomatology, The First People's Hospital of Changde, Changde, 415003, People's Republic of China.
authors.forename: Jingmin
authors.initials: J
authors.lastname: You
authors.affiliation: Department of Oral and Maxillofacial Surgery, Xiangya Hospital, Central-South University, Changsha, 410008, People's Republic of China.
authors.forename: Yunmei
authors.initials: Y
authors.lastname: Qian
authors.affiliation: Department of Oral and Maxillofacial Surgery, Xiangya Hospital, Central-South University, Changsha, 410008, People's Republic of China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Han
authors.affiliation: Department of Oral and Maxillofacial Surgery, Xiangya Hospital, Central-South University, Changsha, 410008, People's Republic of China.
authors.forename: Haofeng
authors.initials: H
authors.lastname: Xiong
authors.affiliation: State Key Laboratory of Medical Genetics, Central South University, Changsha, 410078, People's Republic of China.
authors.forename: Tengfei
authors.initials: T
authors.lastname: Zhu
authors.affiliation: State Key Laboratory of Medical Genetics, Central South University, Changsha, 410078, People's Republic of China.
authors.forename: Kun
authors.initials: K
authors.lastname: Xia
authors.affiliation: Department of Oral and Maxillofacial Surgery, Xiangya Hospital, Central-South University, Changsha, 410008, People's Republic of China.
authors.forename: Tong
authors.initials: T
authors.lastname: Su
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D015972:Gene Expression Regulation, Neoplastic; D020662:Guanine Nucleotide Exchange Factors / Q000235:genetics*; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D009062:Mouth Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D009364:Neoplasm Recurrence, Local; D011379:Prognosis; D000075684:T-Lymphoma Invasion and Metastasis-inducing Protein 1
chemical_list: D020662:Guanine Nucleotide Exchange Factors; D000075684:T-Lymphoma Invasion and Metastasis-inducing Protein 1; C087334:TIAM1 protein, human
keywords: OSCC s; TIAM1; metastasi; recurrence