title: Role of Membrane Lipids in the Regulation of Erythrocytic Oxygen-Transport Function in Cardiovascular Diseases.
abstract: The composition and condition of membrane lipids, the morphology of erythrocytes, and hemoglobin distribution were explored with the help of laser interference microscopy (LIM) and Raman spectroscopy. It is shown that patients with cardiovascular diseases (CVD) have significant changes in the composition of their phospholipids and the fatty acids of membrane lipids. Furthermore, the microviscosity of the membranes and morphology of the erythrocytes are altered causing disordered oxygen transport by hemoglobin. Basic therapy carried out with the use of antiaggregants, statins, antianginals, beta-blockers, and calcium antagonists does not help to recover the morphofunctional properties of erythrocytes. Based on the results the authors assume that, for the relief of the ischemic crisis and further therapeutic treatment, it is necessary to include, in addition to cardiovascular disease medicines, medication that increases the ability of erythrocytes' hemoglobin to transport oxygen to the tissues. We assume that the use of LIM and Raman spectroscopy is advisable for early diagnosis of changes in the structure and functional state of erythrocytes when cardiovascular diseases develop.
authors.affiliation: Federal State-Financed Academic Institution of Higher Education "National Research Ogarev Mordovia State University", Saransk 430005, Russia.
authors.forename: Victor V
authors.initials: VV
authors.lastname: Revin
authors.affiliation: Federal State-Financed Academic Institution of Higher Education "National Research Ogarev Mordovia State University", Saransk 430005, Russia.
authors.forename: Natalia V
authors.identifier: 0000-0001-6714-746X
authors.initials: NV
authors.lastname: Gromova
authors.affiliation: Federal State-Financed Academic Institution of Higher Education "National Research Ogarev Mordovia State University", Saransk 430005, Russia.
authors.forename: Elvira S
authors.initials: ES
authors.lastname: Revina
authors.affiliation: Federal State-Financed Academic Institution of Higher Education "National Research Ogarev Mordovia State University", Saransk 430005, Russia.
authors.forename: Maria I
authors.initials: MI
authors.lastname: Martynova
authors.affiliation: Federal State-Financed Academic Institution of Higher Education "National Research Ogarev Mordovia State University", Saransk 430005, Russia.
authors.forename: Angelina I
authors.initials: AI
authors.lastname: Seikina
authors.affiliation: Federal State-Financed Academic Institution of Higher Education "National Research Ogarev Mordovia State University", Saransk 430005, Russia.
authors.forename: Nadezhda V
authors.initials: NV
authors.lastname: Revina
authors.affiliation: GBUZ RM "National Hospital for War Veterans", Saransk 430005, Russia.
authors.forename: Oksana G
authors.initials: OG
authors.lastname: Imarova
authors.affiliation: Federal State-Financed Academic Institution of Higher Education "National Research Ogarev Mordovia State University", Saransk 430005, Russia.
authors.forename: Ilia N
authors.initials: IN
authors.lastname: Solomadin
authors.affiliation: Federal State-Financed Academic Institution of Higher Education "National Research Ogarev Mordovia State University", Saransk 430005, Russia.
authors.forename: Alexander Yu
authors.initials: AY
authors.lastname: Tychkov
authors.affiliation: CMCBR, Abertay University, Dundee DD1 1HG, UK.
authors.forename: Nikolai
authors.initials: N
authors.lastname: Zhelev
mesh_terms: D000787:Angina Pectoris / Q000150:complications / Q000503:physiopathology; D001158:Arteries / Q000503:physiopathology; D002318:Cardiovascular Diseases / Q000378:metabolism*; D004910:Erythrocyte Membrane / Q000737:chemistry; D004912:Erythrocytes / Q000166:cytology / Q000378:metabolism*; D006454:Hemoglobins / Q000737:chemistry; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000503:physiopathology; D000860:Hypoxia / Q000503:physiopathology; D008051:Lipid Bilayers / Q000737:chemistry; D008055:Lipids / Q000737:chemistry*; D008246:Lysophospholipids / Q000737:chemistry; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000737:chemistry*; D013059:Spectrum Analysis, Raman
chemical_list: D006454:Hemoglobins; D008051:Lipid Bilayers; D008055:Lipids; D008246:Lysophospholipids; D010100:Oxygen