title: Transcranial Magnetic Stimulation Modulates Resting EEG Functional Connectivity Between the Left Dorsolateral Prefrontal Cortex and Limbic Regions in Medicated Patients With Treatment-Resistant Depression.
abstract: High-frequency left prefrontal repetitive transcranial magnetic stimulation (rTMS) has been shown to have efficacy in treatment-resistant depression. However, the effects of rTMS on functional connectivity are still not clear. To examine changes in functional connectivity before and after rTMS, resting EEG of 14 patients with treatment-resistant depression was recorded twice at baseline and at week 4, respectively. The EEG data were analyzed using the standardized low-resolution brain electromagnetic tomography (sLORETA). The results reveal that high-frequency left prefrontal rTMS modulates resting EEG functional connectivity between the left dorsolateral prefrontal cortex and limbic regions, including the subgenual cingulate cortex and parahippocampal gyrus.
authors.affiliation: From the Department of Psychiatry and Advanced Medical Technology, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan (SK); the Department of Neuropsychiatry, Kyorin University School of Medicine, Tokyo, Japan (SK, TH, YK); the Department of Psychiatry, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan (TN); the Clinical Optic Imaging Section, Department of Clinical Neuroimaging, Integrative Brain Imaging Center, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan, (TN); the National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan, (KN); and the National Center of Neurology and Psychiatry, Tokyo, Japan (TH).
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Kito
authors.affiliation: From the Department of Psychiatry and Advanced Medical Technology, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan (SK); the Department of Neuropsychiatry, Kyorin University School of Medicine, Tokyo, Japan (SK, TH, YK); the Department of Psychiatry, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan (TN); the Clinical Optic Imaging Section, Department of Clinical Neuroimaging, Integrative Brain Imaging Center, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan, (TN); the National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan, (KN); and the National Center of Neurology and Psychiatry, Tokyo, Japan (TH).
authors.forename: Takashi
authors.initials: T
authors.lastname: Hasegawa
authors.affiliation: From the Department of Psychiatry and Advanced Medical Technology, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan (SK); the Department of Neuropsychiatry, Kyorin University School of Medicine, Tokyo, Japan (SK, TH, YK); the Department of Psychiatry, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan (TN); the Clinical Optic Imaging Section, Department of Clinical Neuroimaging, Integrative Brain Imaging Center, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan, (TN); the National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan, (KN); and the National Center of Neurology and Psychiatry, Tokyo, Japan (TH).
authors.forename: Akihiro
authors.initials: A
authors.lastname: Takamiya
authors.affiliation: From the Department of Psychiatry and Advanced Medical Technology, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan (SK); the Department of Neuropsychiatry, Kyorin University School of Medicine, Tokyo, Japan (SK, TH, YK); the Department of Psychiatry, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan (TN); the Clinical Optic Imaging Section, Department of Clinical Neuroimaging, Integrative Brain Imaging Center, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan, (TN); the National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan, (KN); and the National Center of Neurology and Psychiatry, Tokyo, Japan (TH).
authors.forename: Takamasa
authors.initials: T
authors.lastname: Noda
authors.affiliation: From the Department of Psychiatry and Advanced Medical Technology, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan (SK); the Department of Neuropsychiatry, Kyorin University School of Medicine, Tokyo, Japan (SK, TH, YK); the Department of Psychiatry, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan (TN); the Clinical Optic Imaging Section, Department of Clinical Neuroimaging, Integrative Brain Imaging Center, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan, (TN); the National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan, (KN); and the National Center of Neurology and Psychiatry, Tokyo, Japan (TH).
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Nakagome
authors.affiliation: From the Department of Psychiatry and Advanced Medical Technology, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan (SK); the Department of Neuropsychiatry, Kyorin University School of Medicine, Tokyo, Japan (SK, TH, YK); the Department of Psychiatry, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan (TN); the Clinical Optic Imaging Section, Department of Clinical Neuroimaging, Integrative Brain Imaging Center, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan, (TN); the National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan, (KN); and the National Center of Neurology and Psychiatry, Tokyo, Japan (TH).
authors.forename: Teruhiko
authors.initials: T
authors.lastname: Higuchi
authors.affiliation: From the Department of Psychiatry and Advanced Medical Technology, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan (SK); the Department of Neuropsychiatry, Kyorin University School of Medicine, Tokyo, Japan (SK, TH, YK); the Department of Psychiatry, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan (TN); the Clinical Optic Imaging Section, Department of Clinical Neuroimaging, Integrative Brain Imaging Center, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan, (TN); the National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan, (KN); and the National Center of Neurology and Psychiatry, Tokyo, Japan (TH).
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Koga
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001611:Beta Rhythm / Q000502:physiology; D061218:Depressive Disorder, Treatment-Resistant / Q000628:therapy*; D004569:Electroencephalography; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017397:Prefrontal Cortex / Q000502:physiology*; D011569:Psychiatric Status Rating Scales; D012146:Rest; D050781:Transcranial Magnetic Stimulation / Q000379:methods*
keywords: Depression; Mood Disorders (Neuropsychiatric Aspects); Neurophysiology