title: Correlations of VDR and VDBP genetic polymorphisms with susceptibility to adolescent idiopathic scoliosis and efficacy of brace treatment.
abstract: This paper aimed to elucidate the correlations of VDR and VDBP polymorphisms with susceptibility to adolescent idiopathic scoliosis (AIS) and efficacy of brace treatment.
  
  
  
  AIS patients and healthy controls were enrolled. Lumbar spine bone mineral density (LSBMD) and femoral neck bone mineral density (FNBMD) were detected by dual energy X-ray absorptiometry. VDR and VDBP polymorphisms were detected by PCR-RFLP. Efficacy of brace treatment was evaluated by Cobb measurement.
  
  
  
  The frequencies of Bsm I Bb genotype and B allele, and rs222020 CC genotype and C allele in the AIS patients were higher than in the controls. After treatment, the correction rates of average Cobb angle, AVT, AVR and TS in patients with Bsm I Bb and VDBP rs222020 CC genotypes were relatively low.
  
  
  
  VDR Bsm I and VDBP rs222020 C>T polymorphisms may be predisposition factors of AIS and the efficacy of brace treatment in AIS patients.
authors.affiliation: Department of Orthopaedics, Peking University First Hospital, Beijing 100034, PR China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Orthopaedics, Tsinghua University Second Hospital, Beijing 100049, PR China. Electronic address: zhiqiang_czq@163.com.
authors.forename: Zhi-Qiang
authors.initials: ZQ
authors.lastname: Cui
authors.affiliation: Department of Orthopaedics, Tsinghua University Second Hospital, Beijing 100049, PR China.
authors.forename: Tian-Bao
authors.initials: TB
authors.lastname: Luo
authors.affiliation: Department of Orthopaedics, Peking University First Hospital, Beijing 100034, PR China.
authors.forename: Long
authors.initials: L
authors.lastname: Liu
mesh_terms: D000293:Adolescent; D000483:Alleles; D001915:Braces; D016022:Case-Control Studies; D005260:Female; D005838:Genotype; D006801:Humans; D019637:Orthopedic Procedures; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D018167:Receptors, Calcitriol / Q000235:genetics*; D012600:Scoliosis / Q000235:genetics* / Q000628:therapy; D016896:Treatment Outcome; D014809:Vitamin D-Binding Protein / Q000235:genetics*
chemical_list: D018167:Receptors, Calcitriol; C579457:VDR protein, human; D014809:Vitamin D-Binding Protein
keywords: Adolescent idiopathic scoliosis; Brace treatment; Efficacy; Polymorphism; VDBP; VDR