title: [CCAFU french national guidelines 2016-2018 on prostate cancer].
abstract: OBJECTIVE
  The purpose of the guidelines national committee CCAFU was to propose updated french guidelines for localized and metastatic prostate cancer (PCa).
  
  
  METHODS
  A Medline search was achieved between 2013 and 2016, as regards diagnosis, options of treatment and follow-up of PCa, to evaluate different references with levels of evidence.
  
  
  RESULTS
  Epidemiology, classification, staging systems, diagnostic evaluation are reported. Disease management options are detailed. Recommandations are reported according to the different clinical situations. Active surveillance is a major option in low risk PCa. Radical prostatectomy remains a standard of care of localized PCa. The three-dimensional conformal radiotherapy is the technical standard. A dose of > 74Gy is recommended. Moderate hypofractionation provides short-term biochemical control comparable to conventional fractionation. In case of intermediate risk PCa, radiotherapy can be combined with short-term androgen deprivation therapy (ADT). In case of high risk disease, long-term ADT remains the standard of care. ADT is the backbone therapy of metastatic disease. In men with metastases at first presentation, upfront chemotherapy combined with ADT should be considered as a new standard. In case of metastatic castration-resistant PCa (mCRPC), new hormonal treatments and chemotherapy provide a better control of tumor progression and increase survival.
  
  
  CONCLUSIONS
  These updated french guidelines will contribute to increase the level of urological care for the diagnosis and treatment for prostate cancer. © 2016 Elsevier Masson SAS. All rights reserved.
authors.affiliation: Comité de cancérologie de l'Association française d'urologie, groupe prostate, maison de l'urologie, 11 rue Viète, 75017 Paris, France.
authors.forename: F
authors.initials: F
authors.lastname: Rozet
authors.affiliation: Comité de cancérologie de l'Association française d'urologie, groupe prostate, maison de l'urologie, 11 rue Viète, 75017 Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Hennequin
authors.affiliation: Comité de cancérologie de l'Association française d'urologie, groupe prostate, maison de l'urologie, 11 rue Viète, 75017 Paris, France.
authors.forename: J-B
authors.initials: JB
authors.lastname: Beauval
authors.affiliation: Comité de cancérologie de l'Association française d'urologie, groupe prostate, maison de l'urologie, 11 rue Viète, 75017 Paris, France.
authors.forename: P
authors.initials: P
authors.lastname: Beuzeboc
authors.affiliation: Comité de cancérologie de l'Association française d'urologie, groupe prostate, maison de l'urologie, 11 rue Viète, 75017 Paris, France.
authors.forename: L
authors.initials: L
authors.lastname: Cormier
authors.affiliation: Comité de cancérologie de l'Association française d'urologie, groupe prostate, maison de l'urologie, 11 rue Viète, 75017 Paris, France.
authors.forename: G
authors.initials: G
authors.lastname: Fromont
authors.affiliation: Comité de cancérologie de l'Association française d'urologie, groupe prostate, maison de l'urologie, 11 rue Viète, 75017 Paris, France.
authors.forename: P
authors.initials: P
authors.lastname: Mongiat-Artus
authors.affiliation: Comité de cancérologie de l'Association française d'urologie, groupe prostate, maison de l'urologie, 11 rue Viète, 75017 Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Ouzzane
authors.affiliation: Comité de cancérologie de l'Association française d'urologie, groupe prostate, maison de l'urologie, 11 rue Viète, 75017 Paris, France.
authors.forename: G
authors.initials: G
authors.lastname: Ploussard
authors.affiliation: Comité de cancérologie de l'Association française d'urologie, groupe prostate, maison de l'urologie, 11 rue Viète, 75017 Paris, France.
authors.forename: D
authors.initials: D
authors.lastname: Azria
authors.affiliation: Comité de cancérologie de l'Association française d'urologie, groupe prostate, maison de l'urologie, 11 rue Viète, 75017 Paris, France.
authors.forename: I
authors.initials: I
authors.lastname: Brenot-Rossi
authors.affiliation: Comité de cancérologie de l'Association française d'urologie, groupe prostate, maison de l'urologie, 11 rue Viète, 75017 Paris, France.
authors.forename: G
authors.initials: G
authors.lastname: Cancel-Tassin
authors.affiliation: Comité de cancérologie de l'Association française d'urologie, groupe prostate, maison de l'urologie, 11 rue Viète, 75017 Paris, France.
authors.forename: O
authors.initials: O
authors.lastname: Cussenot
authors.affiliation: Comité de cancérologie de l'Association française d'urologie, groupe prostate, maison de l'urologie, 11 rue Viète, 75017 Paris, France.
authors.forename: T
authors.initials: T
authors.lastname: Lebret
authors.affiliation: Comité de cancérologie de l'Association française d'urologie, groupe prostate, maison de l'urologie, 11 rue Viète, 75017 Paris, France.
authors.forename: X
authors.initials: X
authors.lastname: Rebillard
authors.affiliation: Comité de cancérologie de l'Association française d'urologie, groupe prostate, maison de l'urologie, 11 rue Viète, 75017 Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Soulié
authors.affiliation: Comité de cancérologie de l'Association française d'urologie, groupe prostate, maison de l'urologie, 11 rue Viète, 75017 Paris, France.
authors.forename: R
authors.initials: R
authors.lastname: Renard-Penna
authors.affiliation: Comité de cancérologie de l'Association française d'urologie, groupe prostate, maison de l'urologie, 11 rue Viète, 75017 Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Méjean
mesh_terms: D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000628:therapy*
keywords: (MeSH) Cancer de la prostate; (MeSH) Prostate; Diagnosis; Diagnostic; Guidelines; Recommandations; Traitement; Treatment; cancer