title: Preoperative platelet to lymphocyte and neutrophil to lymphocyte ratios are independent prognostic factors for patients undergoing lung cancer radical surgery: A single institutional cohort study.
abstract: BACKGROUND
  The aim of this study was to assess the prognostic value for NSCLC patients who were scheduled to receive lung cancer radical resection.
  
  
  METHODS
  In this cohort study (Dec.2014-Feb.2016), patients with non-small cell lung cancer (NSCLC) who underwent radical lung cancer thoracotomy were enrolled and accessed at postoperative complications, one-year overall survival (OS) and relapse-free survival (RFS). The preoperative PLR and NLR of all patients were calculated based on preoperative complete blood counts. Univariate and multivariate Cox regression analyses were performed to determine the associations of PLR and NLR with OS and RFS.
  
  
  RESULTS
  A total of 174 NSCLC patients were studied. The results indicated that both high PLR (>148.6) and NLR (>2.9) were related to a high rate of postoperative pulmonary complications significantly (49.3%vs.29.1%, P = 0.007; 50.7% vs. 28.6%, P = 0.003). Moreover, NSCLC patients with a high PLR level (> 148.6) was significantly associated with a lower one-year OS (90.3% vs. 77.5%, P = 0.034).
  
  
  CONCLUSIONS
  Preoperative PLR and NLR were good prognostic factors for postoperative pulmonary complications and OS in NSCLC patients undergoing radical lung cancer surgery. Thus, blood PLR and NLR would be helpful as a prognostic tool before radical lung cancer surgery.
authors.affiliation: Department of Anesthesiology, West China Hospital of Sichuan University, Chengdu, Sichuan, China, Guo Xue Xiang, Chengdu, Sichuan, P.R. of China.
authors.forename: Haidan
authors.initials: H
authors.lastname: Lan
authors.affiliation: Department of Anesthesiology, West China Hospital of Sichuan University, Chengdu, Sichuan, China, Guo Xue Xiang, Chengdu, Sichuan, P.R. of China.
authors.forename: Leng
authors.initials: L
authors.lastname: Zhou
authors.affiliation: Department of Anesthesiology, West China Hospital of Sichuan University, Chengdu, Sichuan, China, Guo Xue Xiang, Chengdu, Sichuan, P.R. of China.
authors.forename: Dongmei
authors.initials: D
authors.lastname: Chi
authors.affiliation: The lung cancer center, West China Hospital of Sichuan University, Chengdu, Sichuan, China, Guo Xue Xiang, Chengdu, Sichuan, P.R. of China.
authors.forename: Qinghua
authors.initials: Q
authors.lastname: Zhou
authors.affiliation: The lung cancer center, West China Hospital of Sichuan University, Chengdu, Sichuan, China, Guo Xue Xiang, Chengdu, Sichuan, P.R. of China.
authors.forename: XiaoJun
authors.initials: X
authors.lastname: Tang
authors.affiliation: The lung cancer center, West China Hospital of Sichuan University, Chengdu, Sichuan, China, Guo Xue Xiang, Chengdu, Sichuan, P.R. of China.
authors.forename: Daxing
authors.initials: D
authors.lastname: Zhu
authors.affiliation: Department of Anesthesiology, West China Hospital of Sichuan University, Chengdu, Sichuan, China, Guo Xue Xiang, Chengdu, Sichuan, P.R. of China.
authors.forename: Jianmin
authors.initials: J
authors.lastname: Yue
authors.affiliation: Department of Anesthesiology, West China Hospital of Sichuan University, Chengdu, Sichuan, China, Guo Xue Xiang, Chengdu, Sichuan, P.R. of China.
authors.forename: Bin
authors.initials: B
authors.lastname: Liu
mesh_terms: D000368:Aged; D001772:Blood Cell Count; D002289:Carcinoma, Non-Small-Cell Lung / Q000097:blood* / Q000601:surgery*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood* / Q000601:surgery*; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D057234:Preoperative Period; D011379:Prognosis; D012189:Retrospective Studies; D013908:Thoracotomy; D016896:Treatment Outcome
keywords: neutrophil to lymphocyte ratio; non small cell lung cancer; overall survival; platelet to lymphocyte ratio; postoperative pulmonary complications