title: Acanthopanax senticosus: Photochemistry and Anticancer Potential.
abstract: Acanthopanax senticosus (previously classified as Eleutherococcus senticosus), commonly known as Ciwujia or Siberian Ginseng, is a traditional Chinese medicine (TCM), widely used for its high medicinal value, such as antifatigue, anti-inflammation, antistress, anti-ulcer and cardiovascular functions, in China, Korea, Japan and Russia. In the past decades, researchers worldwide have conducted systematic investigations on this herb, from chemistry to pharmacology, and a large number of chemical components have been characterized for their significant pharmacological effects. However, reports about the anticancer effects of this plant had been rare until recently, when considerable pharmacological experiments both in vitro and in vivo were conducted to study the anticancer effects of this herb. A. senticosus has been found to have inhibitory effects on malignant tumors, such as those in the lung and liver, suggesting that A. senticosus has potential to be developed as an effective anticancer drug. This paper reviews recent findings on the pharmacological properties of A. senticosus, with a focus on its anticancer effects.
authors.affiliation: * Systemomics Center, College of Pharmacy, and Genomics Research Center, (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin Medical University, Harbin, 150081, P.R. China.
authors.forename: Ting
authors.initials: T
authors.lastname: Li
authors.affiliation: * Systemomics Center, College of Pharmacy, and Genomics Research Center, (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin Medical University, Harbin, 150081, P.R. China.|§ Department of Biology, University of British Columbia, Vancouver, Canada.
authors.forename: Kelsey
authors.initials: K
authors.lastname: Ferns
authors.affiliation: * Systemomics Center, College of Pharmacy, and Genomics Research Center, (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin Medical University, Harbin, 150081, P.R. China.
authors.forename: Zi-Qiao
authors.initials: ZQ
authors.lastname: Yan
authors.affiliation: * Systemomics Center, College of Pharmacy, and Genomics Research Center, (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin Medical University, Harbin, 150081, P.R. China.
authors.forename: Si-Yuan
authors.initials: SY
authors.lastname: Yin
authors.affiliation: * Systemomics Center, College of Pharmacy, and Genomics Research Center, (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin Medical University, Harbin, 150081, P.R. China.
authors.forename: Jun-Jie
authors.initials: JJ
authors.lastname: Kou
authors.affiliation: * Systemomics Center, College of Pharmacy, and Genomics Research Center, (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin Medical University, Harbin, 150081, P.R. China.
authors.forename: Dongsheng
authors.initials: D
authors.lastname: Li
authors.affiliation: * Systemomics Center, College of Pharmacy, and Genomics Research Center, (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin Medical University, Harbin, 150081, P.R. China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Zeng
authors.affiliation: * Systemomics Center, College of Pharmacy, and Genomics Research Center, (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin Medical University, Harbin, 150081, P.R. China.
authors.forename: Lin
authors.initials: L
authors.lastname: Yin
authors.affiliation: * Systemomics Center, College of Pharmacy, and Genomics Research Center, (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin Medical University, Harbin, 150081, P.R. China.
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Wang
authors.affiliation: * Systemomics Center, College of Pharmacy, and Genomics Research Center, (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin Medical University, Harbin, 150081, P.R. China.
authors.forename: Hong-Xia
authors.initials: HX
authors.lastname: Bao
authors.affiliation: * Systemomics Center, College of Pharmacy, and Genomics Research Center, (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin Medical University, Harbin, 150081, P.R. China.
authors.forename: Yu-Jie
authors.initials: YJ
authors.lastname: Zhou
authors.affiliation: * Systemomics Center, College of Pharmacy, and Genomics Research Center, (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin Medical University, Harbin, 150081, P.R. China.
authors.forename: Qing-Hai
authors.initials: QH
authors.lastname: Li
authors.affiliation: * Systemomics Center, College of Pharmacy, and Genomics Research Center, (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin Medical University, Harbin, 150081, P.R. China.
authors.forename: Zhan-Yi
authors.initials: ZY
authors.lastname: Zhao
authors.affiliation: * Systemomics Center, College of Pharmacy, and Genomics Research Center, (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin Medical University, Harbin, 150081, P.R. China.|† HMU-UCFM Centre for Infection and Genomics, Harbin, P.R. China.|‡ Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Canada.
authors.forename: Huidi
authors.initials: H
authors.lastname: Liu
authors.affiliation: * Systemomics Center, College of Pharmacy, and Genomics Research Center, (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin Medical University, Harbin, 150081, P.R. China.|† HMU-UCFM Centre for Infection and Genomics, Harbin, P.R. China.|¶ Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, Canada.
authors.forename: Shu-Lin
authors.initials: SL
authors.lastname: Liu
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use*; D000975:Antioxidants; D003374:Coumarins / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use*; D004149:Dioxoles / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D028001:Eleutherococcus / Q000737:chemistry*; D005960:Glucosides / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use*; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use; D017705:Lignans / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use*; D008516:Medicine, Chinese Traditional; D051379:Mice; D010666:Phenylpropionates / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use*; D008517:Phytotherapy; D051381:Rats
chemical_list: D000893:Anti-Inflammatory Agents; D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants; D003374:Coumarins; D004149:Dioxoles; D005960:Glucosides; D007155:Immunologic Factors; D017705:Lignans; D010666:Phenylpropionates; C008182:isofraxidin; C028305:syringin; C054125:sesamin
keywords: Acanthopanax senticosus; Anticancer; Ciwujia; Pharmacological Effects; Phytochemistry; Review; Siberian Ginseng; Traditional Chinese Medicine