title: Building Compound Archives for the Future.
abstract: Will the targets of the future be covered by the compound libraries of today? This communication will cover a critical review of past strategies before turning to a new measure of diversity, protein pockets. A fingerprint descriptor for pockets will be described.
authors.affiliation: Novartis Pharma AG, Basel, Switzerland.
authors.forename: Richard
authors.initials: R
authors.lastname: Lewis
authors.affiliation: Novartis Pharma AG, Basel, Switzerland.
authors.forename: Joakim
authors.initials: J
authors.lastname: Deheuvels
authors.affiliation: Novartis Pharma AG, Basel, Switzerland.
authors.forename: Peter
authors.initials: P
authors.lastname: Ertl
authors.affiliation: Novartis Pharma AG, Basel, Switzerland.
authors.forename: Bernard
authors.initials: B
authors.lastname: Pirard
authors.affiliation: Novartis Pharma AG, Basel, Switzerland.
authors.forename: Finton
authors.initials: F
authors.lastname: Sirockin
mesh_terms: D001109:Archives; D055808:Drug Discovery / Q000379:methods; D008024:Ligands; D008958:Models, Molecular; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D011485:Protein Binding / Q000502:physiology; D011506:Proteins / Q000378:metabolism
chemical_list: D008024:Ligands; D004364:Pharmaceutical Preparations; D011506:Proteins
keywords: Diversity; Physicochemical properties; Protein pocket analysis