title: Synthesis of axially chiral heterobiaryl alkynes via dynamic kinetic asymmetric alkynylation.
abstract: The dynamic kinetic Pd0-catalyzed alkynylation of racemic heterobiaryl sulfonates was used for the asymmetric synthesis of axially chiral heterobiaryl alkynes with a broad scope. The use of Pd(OAc)2/(S)-QUINAP as the precatalyst provides products in excellent yields and enantioselectivities under mild conditions (DMSO, 40 °C). Semireduction, 1,3-dipolar cycladdition or N-oxidation served to illustrate the synthetic potential of the methodology.
authors.affiliation: Instituto Investigaciones Químicas (CSIC-US), C/Américo Vespucio, 49, 41092 Sevilla, Spain. vhornillos@iiq.csic.es jmlassa@iiq.csic.es.
authors.forename: Valentín
authors.initials: V
authors.lastname: Hornillos
authors.affiliation: Instituto Investigaciones Químicas (CSIC-US), C/Américo Vespucio, 49, 41092 Sevilla, Spain. vhornillos@iiq.csic.es jmlassa@iiq.csic.es and Departamento de Química Orgánica, Universidad de Sevilla, C/Prof. García González, 1, 41012 Sevilla, Spain. ffernan@us.es.
authors.forename: Abel
authors.initials: A
authors.lastname: Ros
authors.affiliation: Instituto Investigaciones Químicas (CSIC-US), C/Américo Vespucio, 49, 41092 Sevilla, Spain. vhornillos@iiq.csic.es jmlassa@iiq.csic.es.
authors.forename: Pedro
authors.initials: P
authors.lastname: Ramírez-López
authors.affiliation: Departamento de Química Orgánica, Universidad de Sevilla, C/Prof. García González, 1, 41012 Sevilla, Spain. ffernan@us.es.
authors.forename: Javier
authors.identifier: http://orcid.org/0000-0001-8846-2303
authors.initials: J
authors.lastname: Iglesias-Sigüenza
authors.affiliation: Departamento de Química Orgánica, Universidad de Sevilla, C/Prof. García González, 1, 41012 Sevilla, Spain. ffernan@us.es.
authors.forename: Rosario
authors.initials: R
authors.lastname: Fernández
authors.affiliation: Instituto Investigaciones Químicas (CSIC-US), C/Américo Vespucio, 49, 41092 Sevilla, Spain. vhornillos@iiq.csic.es jmlassa@iiq.csic.es.
authors.forename: José M
authors.identifier: http://orcid.org/0000-0003-1772-2723
authors.initials: JM
authors.lastname: Lassaletta