title: Hypoglycemic Activity of Polysaccharides from Sweet Corncob on Streptozotocin-Induced Diabetic Rats.
abstract: A water-soluble polysaccharide (SCP-80-I) was isolated from sweet corncob using microwave-assisted compound-enzyme extraction and column chromatography. SCP-80-I is composed mainly of arabinose, mannose, glucose, and galactose in a molar ratio of 0.369:0.824:10.759:0.333, and has a molecular mass of 18350 Da and β-glycosides linkages in its molecular structure. The preliminary hypoglycemic and hypolipidemic activity in streptozotocin-induced diabetic rats was investigated. Rats were administered daily with 100, 200, and 400 mg/kg SCP-80-I for 21 d. The SCP-80-I increased the rat body mass significantly and reduced the blood glucose level in a dose-dependent manner. The SCP-80-I reduced liver swelling; kidney and pancreas hypertrophy; and total cholesterol, triglyceride, and low-density lipoprotein-C levels significantly; and increased the level of high-density lipoproteins in streptozotocin-induced diabetic rats. These results indicate that SCP-80-I exerts a potential hypoglycemic effect in streptozotocin-induced diabetic rats.
authors.affiliation: Key Laboratory Food Science and Engineering, School of Food Engineering, Harbin, Univ. of Commerce, No. 138 Tongda Street, Daoli District, Harbin City, Hei Longjiang, Province China.
authors.forename: Yong Qiang
authors.initials: YQ
authors.lastname: Ma
authors.affiliation: Key Laboratory Food Science and Engineering, School of Food Engineering, Harbin, Univ. of Commerce, No. 138 Tongda Street, Daoli District, Harbin City, Hei Longjiang, Province China.
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.affiliation: Key Laboratory Food Science and Engineering, School of Food Engineering, Harbin, Univ. of Commerce, No. 138 Tongda Street, Daoli District, Harbin City, Hei Longjiang, Province China.
authors.forename: Shuang
authors.initials: S
authors.lastname: Gao
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism*; D002784:Cholesterol / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000097:blood* / Q000188:drug therapy / Q000473:pathology; D005690:Galactose / Q000032:analysis; D007004:Hypoglycemic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008297:Male; D008358:Mannose / Q000032:analysis; D010179:Pancreas / Q000473:pathology; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D018514:Plant Structures / Q000737:chemistry; D011134:Polysaccharides / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology*; D017208:Rats, Wistar; D013311:Streptozocin; D014280:Triglycerides / Q000097:blood; D003313:Zea mays / Q000737:chemistry*
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D010936:Plant Extracts; D011134:Polysaccharides; D014280:Triglycerides; D013311:Streptozocin; D002784:Cholesterol; D008358:Mannose; D005690:Galactose
keywords: hypoglycemic; polysaccharides; sweet corncob