title: Stem Cells as a Promising Tool for the Restoration of Brain Neurovascular Unit and Angiogenic Orientation.
abstract: Establishing systemic therapeutics for neuro-inflammatory diseases is a main objective of regenerative medicine, certainly focusing on restoration of BBB dysfunction and neurovascular reconstitution. In this context, the regenerative capacity and therapeutic effects of different stem cells have been recently found to bring hopeful outcomes through trans-differentiation, paracrine interactions, and molecular cross-talk of transplanted stem cells with resident cells of blood-brain barrier. Here, we highlight some of the most recent scientific breakthroughs and discoveries by different authorities. Potency of different types of stem cells on the regulation and maintenance of endothelial and perivascular cells via various microRNAs was also studied.
authors.affiliation: Neuroscience Research Center, Imam Reza Medical Center, Tabriz University of Medical Sciences, Golgasht St., Azadi Ave, Tabriz, 5166614756, Iran.|Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.|Department of Physiology, Tabriz Branch, Islamic Azad University, Tabriz, Iran.
authors.forename: Mohammad Hossein
authors.initials: MH
authors.lastname: Geranmayeh
authors.affiliation: Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.|Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Alireza
authors.initials: A
authors.lastname: Nourazarian
authors.affiliation: Department of Medical Biology, Faculty of Medicine, Ege University, Izmir, Turkey.
authors.forename: Çığır Biray
authors.initials: ÇB
authors.lastname: Avci
authors.affiliation: Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Rezarahbardvm@gmail.com.|Department of Applied Cell Sciences, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Imam Reza St., Golgasht St, Tabriz, 5166614756, Iran. Rezarahbardvm@gmail.com.
authors.forename: Reza
authors.initials: R
authors.lastname: Rahbarghazi
authors.affiliation: Neuroscience Research Center, Imam Reza Medical Center, Tabriz University of Medical Sciences, Golgasht St., Azadi Ave, Tabriz, 5166614756, Iran. farhoudi_m@yahoo.com.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Farhoudi
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier / Q000502:physiology*; D001921:Brain / Q000098:blood supply* / Q000166:cytology / Q000502:physiology*; D002454:Cell Differentiation / Q000502:physiology; D006801:Humans; D018919:Neovascularization, Physiologic / Q000502:physiology*; D012038:Regeneration / Q000502:physiology; D033581:Stem Cell Transplantation / Q000639:trends; D013234:Stem Cells / Q000502:physiology*
keywords: Brain neurovascular unit; MicroRNAs; Paracrine behavior; Stem cell; Trans-differentiation