title: Perinatal outcomes and cost-effectivity of the assisted reproduction pregnancies with advanced age: A retrospective analysis.
abstract: We demonstrated the IVF-ICSI results, perinatal outcomes and cost-effectivity of the patients with advanced age at a tertiary centre. A total of 456 patients categorised into two groups according to age: group 1 (n = 158) (≥39years) and group 2 (n = 298) (<39years) were analysed retrospectively. In addition, subgroup analysis was performed according to the 40 years cut-off. Clinical pregnancy rate was significantly different between the groups (p< .001). Preterm delivery (< 37 gestational week) and low birth weight (< 2500 g) were significantly higher in advanced aged women than youngsters (p< .001). Mean expense per cycle for hormonal stimulation of IVF-ICSI was 1058.9 and 723.5 USD in groups 1 and 2, respectively (p< .001). Mean expense per pregnancy was 9294.7 and 1874.8 USD in groups 1 and 2, respectively (p< .001). Our study showed that perinatal outcomes and cost-effectivity might be adversely affected with increasing age.
authors.affiliation: a Department of Obstetrics and Gynecology , Zekai Tahir Burak Women's Health Education and Research Hospital , Ankara , Turkey.
authors.forename: Nafiye
authors.initials: N
authors.lastname: Yilmaz
authors.affiliation: b Department of Obstetrics and Gynecology, School of Medicine , Bozok University , Yozgat , Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Kara
authors.affiliation: a Department of Obstetrics and Gynecology , Zekai Tahir Burak Women's Health Education and Research Hospital , Ankara , Turkey.
authors.forename: Bugra
authors.initials: B
authors.lastname: Coskun
authors.affiliation: c Department of Obstetrics and Gynecology, School of Medicine , Akdeniz University , Antalya , Turkey.
authors.forename: Metin
authors.initials: M
authors.lastname: Kaba
authors.affiliation: a Department of Obstetrics and Gynecology , Zekai Tahir Burak Women's Health Education and Research Hospital , Ankara , Turkey.
authors.forename: Selçuk
authors.initials: S
authors.lastname: Erkilinc
authors.affiliation: a Department of Obstetrics and Gynecology , Zekai Tahir Burak Women's Health Education and Research Hospital , Ankara , Turkey.
authors.forename: Okan
authors.initials: O
authors.lastname: Yenicesu
authors.affiliation: a Department of Obstetrics and Gynecology , Zekai Tahir Burak Women's Health Education and Research Hospital , Ankara , Turkey.
authors.forename: Salim
authors.initials: S
authors.lastname: Erkaya
mesh_terms: D000328:Adult; D000367:Age Factors; D001724:Birth Weight / Q000502:physiology*; D003362:Cost-Benefit Analysis; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008423:Maternal Age; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000191:economics; D018873:Pregnancy Rate; D012189:Retrospective Studies; D020554:Sperm Injections, Intracytoplasmic / Q000191:economics* / Q000706:statistics & numerical data
keywords: Advanced age; IVF-ICSI; cost-effectivity; infertility; perinatal outcomes