title: Injectable Recombinant Human Platelet-derived Growth Factor in Collagen Carrier for Hindfoot Fusion.
abstract: Arthrodesis of the hindfoot is a common procedure for degenerative joint disease and/or severe deformity. Nonunion is a common complication from this procedure, causing an increased burden to the patient and health care system, often resulting in the need for revision surgery. Recombinant human platelet-derived growth factor (rhPDGF) has been shown to be a safe and effective tool to enhance arthrodesis rates in hindfoot surgery while avoiding the potential morbidity of bone grafting. This article provides a review of the role of rhPDGF in hindfoot fusions, and the surgical technique for performing an rhPDGF enhanced double-arthrodesis through a medial approach.
authors.affiliation: Division of Orthopaedic Surgery, St. Michael's Hospital, University of Toronto, 800-55 Queen Street East, Toronto, Ontario M5C 1R6, Canada.
authors.forename: Andrew
authors.initials: A
authors.lastname: Dodd
authors.affiliation: Division of Orthopaedic Surgery, St. Michael's Hospital, University of Toronto, 800-55 Queen Street East, Toronto, Ontario M5C 1R6, Canada. Electronic address: DanielsT@smh.ca.
authors.forename: Timothy R
authors.initials: TR
authors.lastname: Daniels
mesh_terms: D000843:Ankle Joint / Q000187:drug effects / Q000601:surgery*; D001174:Arthrodesis / Q000009:adverse effects / Q000379:methods*; D000077214:Becaplermin; D016025:Bone Transplantation; D003094:Collagen / Q000008:administration & dosage*; D005528:Foot / Q000601:surgery*; D005599:Fractures, Ununited / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D007267:Injections; D020574:Proto-Oncogene Proteins c-sis / Q000008:administration & dosage*
chemical_list: D020574:Proto-Oncogene Proteins c-sis; D000077214:Becaplermin; D003094:Collagen
keywords: Hindfoot arthrodesis; Medial approach; Surgical technique; rh-PDGF