title: The debate: Treatment after the first seizure - The CONTRA.
abstract: In many instances antiepileptic drug (AED) treatment of epilepsy patients is sustained for a long time and is even a lifelong therapy. Chronic drug treatment naturally means the potential burden of adverse effects. The prognosis to remain seizure-free is good after a first seizure even without AEDs. Therefore one has to consider the possibility that freedom from seizures when AED treatment has been initiated after the first seizure may not in fact be the result of the AED treatment. On the other hand seizure-free patients without severe side effects most probably will not consider discontinuing AEDs. Therefore in these cases it will not be possible to discover whether AEDs are really necessary to maintain freedom from seizures. Furthermore it has been shown that the long-term prognosis is independent of whether AED treatment started after the first or a following seizure. Therefore in most instances AED treatment after a first seizure should be avoided.
authors.affiliation: Kork Epilepsy Centre, Kehl-Kork, Germany. Electronic address: bsteinhoff@epilepsiezentrum.de.
authors.forename: Bernhard J
authors.initials: BJ
authors.lastname: Steinhoff
mesh_terms: D000927:Anticonvulsants / Q000627:therapeutic use*; D006801:Humans; D012008:Recurrence; D012640:Seizures / Q000175:diagnosis / Q000188:drug therapy*
chemical_list: D000927:Anticonvulsants
keywords: Contra; Epilepsy; First seizure; Treatment