title: Cationic gemini pyrrolidinium surfactants based sweeping-micellar electrokinetic chromatography for simultaneous detection of nine organic pollutants in environmental water.
abstract: A series of novel cationic gemini surfactants with pyrrolidinium head groups, 1,1'-(butane-1,s-alkyl) bis (1-alkylpyrrolidinium) (Cn-4-CnPB, n=12, 14, 16), were employed as carriers in sweeping-micellar electrokinetic chromatography (sweeping-MEKC) for simultaneous detection of nine organic water pollutants, including polycyclic aromatic hydrocarbons, sulfonamides and steroids. The sweeping and separation conditions were optimized. Cn-4-CnPB (n=12, 14, 16) were compared with cetyltrimethylammonium bromide (CTAB) in terms of their abilities to preconcentrate and separate the nine analytes. Under the optimized conditions, the sensitivity enhancement factors based on the peak height (SEFsHeight) were ca. 310-580 of C16-4-C16PB, which were higher than those of C14-4-C14PB (120-290) and C12-4-C12PB (110-160). Meanwhile, the SEFsHeightof C16-4-C16PB were higher than those of 30% (v/v) methanol-modified CTAB (140-320). The C16-4-C16PB based sweeping-MEKC, coupled with offline solid phase extraction and UV detection (228nm), was used to analyze spiked environmental water samples. The nine analytes were successfully separated and detected. The limit of detection (S/N=3) was in range of 2.79-3.76ng/mL, and the recovery ranged from 70.8% to 95.5% with the RSDs less than 9.89%. This study confirms that the C16-4-C16PB based sweeping-MEKC has significant advantages over the CTAB based sweeping-MEKC and it is a promising method for sensitive and simultaneous detection of polycyclic aromatic hydrocarbons, sulfonamides and steroids in environmental water samples.
authors.affiliation: Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Ministry of Education), and School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Tian
authors.affiliation: Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Ministry of Education), and School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China.
authors.forename: Ran
authors.initials: R
authors.lastname: Wei
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Cai
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, China.
authors.forename: Jinfeng
authors.initials: J
authors.lastname: Dong
authors.affiliation: Chemistry Department, York University, 4700 Keele Street, Toronto, ON, M3J1P3, Canada.
authors.forename: Bin
authors.initials: B
authors.lastname: Deng
authors.affiliation: Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Ministry of Education), and School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China. Electronic address: yuxiuxiao2011@whu.edu.cn.
authors.forename: Yuxiu
authors.initials: Y
authors.lastname: Xiao
mesh_terms: D002412:Cations; D000077286:Cetrimonium; D002593:Cetrimonium Compounds / Q000737:chemistry; D020374:Chromatography, Micellar Electrokinetic Capillary / Q000379:methods*; D011759:Pyrrolidines / Q000737:chemistry*; D052616:Solid Phase Extraction; D013501:Surface-Active Agents / Q000737:chemistry*; D014874:Water Pollutants, Chemical / Q000032:analysis* / Q000302:isolation & purification
chemical_list: D002412:Cations; D002593:Cetrimonium Compounds; D011759:Pyrrolidines; D013501:Surface-Active Agents; D014874:Water Pollutants, Chemical; D000077286:Cetrimonium
keywords: Environmental water; Micellar electrokinetic chromatography; Organic pollutant; Pyrrolidinium gemini surfactant; Sweeping