title: Safety and Efficacy of Granulocyte Colony-Stimulating Factor Monotherapy for Peripheral Blood Stem Cell Collection in POEMS Syndrome.
abstract: Although autologous stem cell transplantation can achieve excellent responses in patients with POEMS syndrome, the optimal regimen for peripheral blood stem cell (PBSC) collection is still controversial. We retrospectively investigated the safety and efficacy of 41 PBSC collecting procedures in 37 patients with POEMS syndrome. PBSC mobilization was performed using cyclophosphamide + granulocyte colony-stimulating factor (G-CSF) (CG, n = 14) or G-CSF alone (G, n = 27). Twelve (85.7%) patients in the CG group and all (100%) patients in the G group received induction chemotherapy before PBSC collection. The proportions of good mobilizers (≥2.0 × 106CD34+cells/kg) were comparable between the 2 groups (CG versus G: 78.6% versus 70.4%, P = .71). Two (14.3%) patients in the CG group developed severe capillary leak symptoms during the PBSC mobilization period, whereas no patient in the G group experienced severe adverse events. Appropriate induction therapies followed by the G-CSF monotherapy compose an optimal strategy for PBSC collection.
authors.affiliation: Department of Hematology, Chiba University Hospital, Chiba, Japan.
authors.forename: Tomoya
authors.initials: T
authors.lastname: Muto
authors.affiliation: Department of Hematology, Chiba University Hospital, Chiba, Japan. Electronic address: chikako_ohwada@faculty.chiba-u.jp.
authors.forename: Chikako
authors.initials: C
authors.lastname: Ohwada
authors.affiliation: Department of Hematology, Chiba University Hospital, Chiba, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Takaishi
authors.affiliation: Department of Hematology, Chiba University Hospital, Chiba, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Isshiki
authors.affiliation: Department of Hematology, Chiba University Hospital, Chiba, Japan.
authors.forename: Yuhei
authors.initials: Y
authors.lastname: Nagao
authors.affiliation: Department of Hematology, Chiba University Hospital, Chiba, Japan.
authors.forename: Nagisa
authors.initials: N
authors.lastname: Hasegawa
authors.affiliation: Department of Hematology, Chiba University Hospital, Chiba, Japan.
authors.forename: Chika
authors.initials: C
authors.lastname: Kawajiri-Manako
authors.affiliation: Department of Hematology, Chiba University Hospital, Chiba, Japan.
authors.forename: Emi
authors.initials: E
authors.lastname: Togasaki
authors.affiliation: Department of Hematology, Chiba University Hospital, Chiba, Japan.
authors.forename: Ryoh
authors.initials: R
authors.lastname: Shimizu
authors.affiliation: Department of Hematology, Chiba University Hospital, Chiba, Japan.
authors.forename: Shokichi
authors.initials: S
authors.lastname: Tsukamoto
authors.affiliation: Department of Hematology, Chiba University Hospital, Chiba, Japan; Department of Transfusion Medicine and Cell Therapy, Chiba University Hospital, Chiba, Japan.
authors.forename: Shio
authors.initials: S
authors.lastname: Sakai
authors.affiliation: Department of Hematology, Chiba University Hospital, Chiba, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Takeda
authors.affiliation: Department of Hematology, Chiba University Hospital, Chiba, Japan; Department of Transfusion Medicine and Cell Therapy, Chiba University Hospital, Chiba, Japan.
authors.forename: Naoya
authors.initials: N
authors.lastname: Mimura
authors.affiliation: Department of Hematology, Chiba University Hospital, Chiba, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Takeuchi
authors.affiliation: Department of Hematology, Chiba University Hospital, Chiba, Japan.
authors.forename: Emiko
authors.initials: E
authors.lastname: Sakaida
authors.affiliation: Department of Neurology, Chiba University Graduate School of Medicine, Chiba, Japan.
authors.forename: Sonoko
authors.initials: S
authors.lastname: Misawa
authors.affiliation: Department of Blood Transfusion, Toho University Medical Center Sakura Hospital, Chiba, Japan.
authors.forename: Naomi
authors.initials: N
authors.lastname: Shimizu
authors.affiliation: Department of Hematology, Chiba University Hospital, Chiba, Japan; Department of Transfusion Medicine and Cell Therapy, Chiba University Hospital, Chiba, Japan.
authors.forename: Tohru
authors.initials: T
authors.lastname: Iseki
authors.affiliation: Department of Neurology, Chiba University Graduate School of Medicine, Chiba, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kuwabara
authors.affiliation: Department of Hematology, Chiba University Hospital, Chiba, Japan.
authors.forename: Chiaki
authors.initials: C
authors.lastname: Nakaseko
mesh_terms: D000328:Adult; D000368:Aged; D001201:Ascites / Q000139:chemically induced; D001772:Blood Cell Count; D004341:Drug Evaluation; D005260:Female; D005334:Fever / Q000139:chemically induced; D016179:Granulocyte Colony-Stimulating Factor / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D019650:Hematopoietic Stem Cell Mobilization; D006801:Humans; D008297:Male; D008875:Middle Aged; D016878:POEMS Syndrome / Q000628:therapy*; D036102:Peripheral Blood Stem Cell Transplantation; D010996:Pleural Effusion / Q000139:chemically induced; D012189:Retrospective Studies
chemical_list: D016179:Granulocyte Colony-Stimulating Factor
keywords: Granulocyte colony–stimulating factor; POEMS syndrome; Stem cell mobilization; Stem cell transplantation