title: Palladium nanoparticles enzyme aggregate (PANEA) as efficient catalyst for Suzuki-Miyaura reaction in aqueous media.
abstract: Palladium nanoparticles enzyme aggregate (PANEA) were prepared from Candida antarctica B lipase and palladium salt by precipitation and subsequent in situ Pd nanoparticle formation. This heterogeneous catalyst was successfully used for the Suzuki-Miyaura cross-coupling reaction between bromobenzene with different phenylboronic acid derivatives under mild reaction conditions and using low Pd amount. The nanocatalyst exhibited the highest catalytic activity in a mixture of methanol/water (1:1), obtaining good to excellent product yields from the cross-coupling reaction. A variety of functional groups were accepted and the catalyst was recycled 4 times without activity loss.
authors.affiliation: Departamento de Biocatálisis, Instituto de Catálisis (CSIC), c/Marie Curie 2, Cantoblanco, Campus UAM, 28049 Madrid, Spain.
authors.forename: Teresa
authors.initials: T
authors.lastname: Cuenca
authors.affiliation: Departamento de Biocatálisis, Instituto de Catálisis (CSIC), c/Marie Curie 2, Cantoblanco, Campus UAM, 28049 Madrid, Spain. Electronic address: marco.filice1@gmail.com.
authors.forename: Marco
authors.initials: M
authors.lastname: Filice
authors.affiliation: Departamento de Biocatálisis, Instituto de Catálisis (CSIC), c/Marie Curie 2, Cantoblanco, Campus UAM, 28049 Madrid, Spain. Electronic address: josempalomo@icp.csic.es.
authors.forename: Jose M
authors.initials: JM
authors.lastname: Palomo
mesh_terms: D055162:Biocatalysis; D001709:Biotechnology; D002175:Candida / Q000201:enzymology; D005656:Fungal Proteins / Q000737:chemistry* / Q000378:metabolism* / Q000648:ultrastructure; D055772:Green Chemistry Technology / Q000379:methods; D008049:Lipase / Q000737:chemistry* / Q000378:metabolism* / Q000648:ultrastructure; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D008958:Models, Molecular; D036103:Nanotechnology; D010165:Palladium / Q000737:chemistry* / Q000378:metabolism*; D066329:Protein Aggregates; D011487:Protein Conformation
chemical_list: D005656:Fungal Proteins; D066329:Protein Aggregates; D010165:Palladium; D008049:Lipase; C431349:lipase B, Candida antarctica
keywords: Aqueous media; Artificial enzyme; Heterogeneous catalysis; Nanocatalysis; Palladium; Suzuki–Miyaura