title: Prediction of Motor Recovery Using Quantitative Parameters of Motor Evoked Potential in Patients With Stroke.
abstract: OBJECTIVE
  To investigate the clinical significance of quantitative parameters in transcranial magnetic stimulation (TMS)-induced motor evoked potentials (MEP) which can be adopted to predict functional recovery of the upper limb in stroke patients in the early subacute phase.
  
  
  METHODS
  One hundred thirteen patients (61 men, 52 women; mean age 57.8±12.2 years) who suffered faiarst-ever stroke were included in this study. All participants underwent TMS-induced MEP session to assess the corticospinal excitability of both hand motor cortices within 3 weeks after stroke onset. After the resting motor threshold (rMT) was assessed, five sweeps of MEP were performed, and the mean amplitude of the MEP was measured. Latency of MEP, volume of the MEP output curve, recruitment ratios, and intracortical inhibition and facilitation were also measured. Motor function was assessed using the Fugl-Meyer Assessment scale (FMA) within 3 weeks and at 3 months after stroke onset. Correlation analysis was performed between TMS-induced MEP derived measures and FMA scores.
  
  
  RESULTS
  In the MEP response group, rMT and rMT ratio measures within 3 weeks after stroke onset showed a significant negative correlation with the total and upper limb FMA scores at 3 months after stroke (p<0.001). Multiple regression analysis revealed that FMA score and rMT ratio, but not rMT within 3 weeks were independent prognostic factors for FMA scores at 3 months after stroke.
  
  
  CONCLUSIONS
  These results indicated that the quantitative parameter of TMS-induced MEP, especially rMT ratio in the early subacute phase, could be used as a parameter to predict motor function in patients with stroke.
authors.affiliation: Department of Physical and Rehabilitation Medicine, Center for Prevention and Rehabilitation, Heart Vascular and Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Jae Yong
authors.identifier: 0000-0002-0878-6779
authors.initials: JY
authors.lastname: Jo
authors.affiliation: Department of Health Science and Technology, Department of Medical Device Management & Research, SAIHST, Sungkyunkwan University, Seoul, Korea.
authors.forename: Ahee
authors.identifier: 0000-0002-8150-2170
authors.initials: A
authors.lastname: Lee
authors.affiliation: Department of Rehabilitation Medicine, Wonkwang University School of Medicine, Iksan, Korea.
authors.forename: Min Su
authors.identifier: 0000-0001-9954-1445
authors.initials: MS
authors.lastname: Kim
authors.affiliation: Department of Physical and Rehabilitation Medicine, Center for Prevention and Rehabilitation, Heart Vascular and Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Eunhee
authors.identifier: 0000-0001-6553-2321
authors.initials: E
authors.lastname: Park
authors.affiliation: Department of Physical and Rehabilitation Medicine, Center for Prevention and Rehabilitation, Heart Vascular and Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Won Hyuk
authors.identifier: 0000-0002-4969-7895
authors.initials: WH
authors.lastname: Chang
authors.affiliation: Department of Rehabilitation Medicine, Pusan National University School of Medicine & Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Korea.
authors.forename: Yong-Il
authors.identifier: 0000-0001-7894-0930
authors.initials: YI
authors.lastname: Shin
authors.affiliation: Department of Physical and Rehabilitation Medicine, Center for Prevention and Rehabilitation, Heart Vascular and Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.; Department of Health Science and Technology, Department of Medical Device Management & Research, SAIHST, Sungkyunkwan University, Seoul, Korea.
authors.forename: Yun-Hee
authors.identifier: 0000-0001-6101-8851
authors.initials: YH
authors.lastname: Kim
keywords: Motor evoked potentials (MEP); Motor recovery; Prognosis; Stroke; Transcranial magnetic stimulation