title: The cryptic IRF2BP2-RARA fusion transforms hematopoietic stem/progenitor cells and induces retinoid-sensitive acute promyelocytic leukemia.
authors.affiliation: King's College London, Faculty of Life Sciences and Medicine, Cancer Genetics Laboratory, Department of Medical and Molecular Genetics, London, UK.
authors.forename: J V
authors.initials: JV
authors.lastname: Jovanovic
authors.affiliation: Hospital Universitario de Salamanca, Instituto de Investigación Biomédica de Salamanca (IBSAL), Centro de Investigación del Cáncer-IBMCC, (USAL-CSIC) Salamanca, Spain.
authors.forename: M C
authors.initials: MC
authors.lastname: Chillón
authors.affiliation: Centre de Recherche en Cancérologie de Marseille U1068 INSERM, UMR 7258 CNRS, Aix-Marseille Université, Marseille, France.
authors.forename: C
authors.initials: C
authors.lastname: Vincent-Fabert
authors.affiliation: King's College London, Faculty of Life Sciences and Medicine, Cancer Genetics Laboratory, Department of Medical and Molecular Genetics, London, UK.
authors.forename: R
authors.initials: R
authors.lastname: Dillon
authors.affiliation: King's College London, Faculty of Life Sciences and Medicine, Cancer Genetics Laboratory, Department of Medical and Molecular Genetics, London, UK.
authors.forename: E
authors.initials: E
authors.lastname: Voisset
authors.affiliation: Hospital Universitario de Salamanca, Instituto de Investigación Biomédica de Salamanca (IBSAL), Centro de Investigación del Cáncer-IBMCC, (USAL-CSIC) Salamanca, Spain.
authors.forename: N C
authors.initials: NC
authors.lastname: Gutiérrez
authors.affiliation: Hospital Universitario de Salamanca, Instituto de Investigación Biomédica de Salamanca (IBSAL), Centro de Investigación del Cáncer-IBMCC, (USAL-CSIC) Salamanca, Spain.
authors.forename: R G
authors.initials: RG
authors.lastname: Sanz
authors.affiliation: Hospital Universitario de Salamanca, Instituto de Investigación Biomédica de Salamanca (IBSAL), Centro de Investigación del Cáncer-IBMCC, (USAL-CSIC) Salamanca, Spain.
authors.forename: A A M
authors.initials: AA
authors.lastname: Lopez
authors.affiliation: Molecular Oncology Section, Cancer Genetics, Viapath, Guy's Hospital, London, UK.
authors.forename: Y G
authors.initials: YG
authors.lastname: Morgan
authors.affiliation: Molecular Oncology Section, Cancer Genetics, Viapath, Guy's Hospital, London, UK.
authors.forename: J
authors.initials: J
authors.lastname: Lok
authors.affiliation: King's College London, Faculty of Life Sciences and Medicine, Cancer Genetics Laboratory, Department of Medical and Molecular Genetics, London, UK.
authors.forename: E
authors.initials: E
authors.lastname: Solomon
authors.affiliation: Centre de Recherche en Cancérologie de Marseille U1068 INSERM, UMR 7258 CNRS, Aix-Marseille Université, Marseille, France.
authors.forename: E
authors.initials: E
authors.lastname: Duprez
authors.affiliation: Hospital Universitario de Salamanca, Instituto de Investigación Biomédica de Salamanca (IBSAL), Centro de Investigación del Cáncer-IBMCC, (USAL-CSIC) Salamanca, Spain.
authors.forename: M G
authors.initials: MG
authors.lastname: Díaz
authors.affiliation: King's College London, Faculty of Life Sciences and Medicine, Cancer Genetics Laboratory, Department of Medical and Molecular Genetics, London, UK.
authors.forename: D
authors.initials: D
authors.lastname: Grimwade
mesh_terms: D000328:Adult; D002352:Carrier Proteins / Q000378:metabolism*; D002884:Chromosomes, Human, Pair 15 / Q000378:metabolism; D002886:Chromosomes, Human, Pair 17 / Q000378:metabolism; D004268:DNA-Binding Proteins; D006412:Hematopoietic Stem Cells / Q000378:metabolism*; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000378:metabolism*; D008297:Male; D009687:Nuclear Proteins / Q000378:metabolism*; D015514:Oncogene Proteins, Fusion / Q000378:metabolism*; D000072482:Retinoic Acid Receptor alpha / Q000378:metabolism*; D012176:Retinoids / Q000378:metabolism*; D013234:Stem Cells / Q000378:metabolism*; D014157:Transcription Factors; D014178:Translocation, Genetic / Q000502:physiology
chemical_list: D002352:Carrier Proteins; D004268:DNA-Binding Proteins; C475082:IRF2BP2 protein, human; D009687:Nuclear Proteins; D015514:Oncogene Proteins, Fusion; C000607071:RARA protein, human; D000072482:Retinoic Acid Receptor alpha; D012176:Retinoids; D014157:Transcription Factors