title: Cyclodextrins: A promising drug delivery vehicle for bisphosphonate.
abstract: Bisphosphonates are well established pharmaceutical drugs with wide applications in medicine. Nevertheless, the side chain and the nature of phosphorous groups could induce a poor aqueous solubility and act on their bioavailability. At the same time, cyclodextrins are cage molecules that facilitate transport of hydrophobic molecules to enhance the intestinal drug absorption of these molecules by forming inclusion complexes. Here we demonstrate that cyclodextrins could be used as a bisphosphonate carrier. The formation of cyclodextrins-bisphosphonate complexes was characterized by 1D and 2D NMR spectroscopy, Isothermal Titration Calorimetry and UV-vis spectroscopy. The results revealed that only the side chain of bisphosphonate was involved in the inclusion phenomenon and its length was a crucial parameter in the control of affinity. Findings from this study suggest that cyclodextrin will be a useful carrier for bisphosphonates.
authors.affiliation: Université Paris 13, CSPBAT UMR 7244 CNRS, F-93017 Bobigny, France.
authors.forename: Maelle
authors.initials: M
authors.lastname: Monteil
authors.affiliation: Université Paris 13, CSPBAT UMR 7244 CNRS, F-93017 Bobigny, France.
authors.forename: Marc
authors.initials: M
authors.lastname: Lecouvey
authors.affiliation: ULCO, UCEIV EA 4492, F-59140 Dunkerque, France.
authors.forename: David
authors.initials: D
authors.lastname: Landy
authors.affiliation: ULCO, UCEIV EA 4492, F-59140 Dunkerque, France.
authors.forename: Steven
authors.initials: S
authors.lastname: Ruellan
authors.affiliation: ULCO, UCEIV EA 4492, F-59140 Dunkerque, France. Electronic address: isabelle.mallard@univ-littoral.fr.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Mallard
mesh_terms: D003505:Cyclodextrins / Q000737:chemistry*; D004164:Diphosphonates / Q000008:administration & dosage / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D012995:Solubility
chemical_list: D003505:Cyclodextrins; D004164:Diphosphonates; D004337:Drug Carriers
keywords: Bisphosphonates; Cyclodextrins; Formation constant; Host-guest complex