title: Recombinant azurin-CdSe/ZnS hybrid structures for nanoscale resistive random access memory device.
abstract: In the present study, we developed a biohybrid material composed of recombinant azurin and CdSe-ZnS quantum dot to perform as a resistive random access memory (ReRAM) device. Site specific amino acid sequences were introduced in azurin to bind with the surface of CdSe-ZnS nanoparticle allowing the formation of a hybrid and voltage-driven switching enabled to develop a resistive random access memory (ReRAM) device. The analytical measurements confirmed that the azurin and CdSe-ZnS nanoparticles were well conjugated and formed into a single hybrid. Further, reversible, bistable switching along with repeatable writing-reading-erasing processes on individual azurin/CdSe-ZnS hybrid at nanoscale was achieved on the hybrid device. The device was programmed tested for 50 cycles with an ON/OFF ratio and measured to be of three orders of magnitude. The developed device shown good stability and repeatability and operates at low voltages thus makes it promising candidate for future memory device applications.
authors.affiliation: Department of Biomedical Engineering, Sogang University, Seoul, 04107, Republic of Korea; Department of Biomedical Engineering, Gachon University, Incheon, 21936, Republic of Korea.
authors.forename: Ajay Kumar
authors.initials: AK
authors.lastname: Yagati
authors.affiliation: Department of Biomedical Engineering, Sogang University, Seoul, 04107, Republic of Korea.
authors.forename: Sang-Uk
authors.initials: SU
authors.lastname: Kim
authors.affiliation: Institute of Integrated Biotechnology, Sogang University, Seoul, 06974, Republic of Korea.
authors.forename: Taek
authors.initials: T
authors.lastname: Lee
authors.affiliation: School of Integrative Engineering, Chung-Ang University, Seoul, 06974, Republic of Korea.
authors.forename: Junhong
authors.initials: J
authors.lastname: Min
authors.affiliation: Department of Biomedical Engineering, Sogang University, Seoul, 04107, Republic of Korea; Department of Chemical & Biomolecular Engineering, Sogang University, Seoul, 04107, Republic of Korea. Electronic address: jwchoi@sogang.ac.kr.
authors.forename: Jeong-Woo
authors.initials: JW
authors.lastname: Choi
mesh_terms: D000595:Amino Acid Sequence / Q000235:genetics; D001400:Azurin / Q000737:chemistry* / Q000235:genetics; D015374:Biosensing Techniques / Q000295:instrumentation* / Q000379:methods; D019187:Cadmium Compounds / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology / Q000295:instrumentation* / Q000379:methods; D045663:Quantum Dots / Q000737:chemistry; D018036:Selenium Compounds / Q000737:chemistry; D012815:Signal Processing, Computer-Assisted; D015032:Zinc / Q000737:chemistry
chemical_list: D019187:Cadmium Compounds; D018036:Selenium Compounds; D001400:Azurin; C058667:cadmium selenide; D015032:Zinc
keywords: Bioelectronic device; Biohybrid; Electrical bistability; Random access memory; Recombinant technology