title: Inflammation Shapes Stem Cells and Stemness during Infection and Beyond.
abstract: The outcome of an inflammatory incident can hang in the balance between restoring health and tissue integrity on the one hand, and promoting aberrant tissue homeostasis and adverse outcomes on the other. Both microbial-related and sterile inflammation is a complex response characterized by a range of innate immune cell types, which produce and respond to cytokine mediators and other inflammatory signals. In turn, cells native to the tissue in question can sense these mediators and respond by migrating, proliferating and regenerating the tissue. In this review we will discuss how the specific outcomes of inflammatory incidents are affected by the direct regulation of stem cells and cellular plasticity. While less well appreciated than the effects of inflammatory signals on immune cells and other differentiated cells, the effects are crucial in understanding inflammation and appropriately managing therapeutic interventions.
authors.affiliation: Department of Biological Sciences, University of Cyprus Nicosia, Cyprus.
authors.forename: Stella
authors.initials: S
authors.lastname: Michael
authors.affiliation: Department of Biological Sciences, University of Cyprus Nicosia, Cyprus.
authors.forename: Charis
authors.initials: C
authors.lastname: Achilleos
authors.affiliation: Department of Biological Sciences, University of Cyprus Nicosia, Cyprus.
authors.forename: Theofano
authors.initials: T
authors.lastname: Panayiotou
authors.affiliation: Department of Biological Sciences, University of Cyprus Nicosia, Cyprus.
authors.forename: Katerina
authors.initials: K
authors.lastname: Strati
keywords: inflammation; stem cells; stem cells and microbes; stem cells and sterile inflammation; stemness