title: Therapeutic potential of Mesenchymal Stem Cells for the treatment of diabetic peripheral neuropathy.
abstract: Type-1 Diabetes is generally treated with exogenous insulin administration. Despite treatment, a very common long term consequence of diabetes is the development of a disabling and painful peripheral neuropathy. The transplantation of pancreatic islets is an advanced alternative therapeutic approach, but its clinical application is still very limited, mainly because of the great number of islets required to complete the procedure and of their short-term survival. An intriguing method to improve the performance of pancreatic islets transplantation is the co-transplantation of Mesenchymal Stem Cells (MSCs), adult stem cells already known to support the survival of different cellular populations. In this proof-of-concept study, we demonstrated using an in vivo model of diabetes, the ability of allogenic MSCs to reduce the number of pancreatic islets necessary to achieve glycemic control in diabetic rats, and overall their positive effect on diabetic neuropathy, with the reduction of all the neuropathic signs showed after disease induction. The cutback of the pancreatic islet number required to control glycemia and the regression of the painful neuropathy make MSC co-transplantation a very promising tool to improve the clinical feasibility of pancreatic islet transplantation for diabetes treatment.
authors.affiliation: Experimental Neurology Unit and Milan Center for Neuroscience, School of Medicine and Surgery, University Milano-Bicocca, Via Cadore 48, 20900 Monza, Italy; PhD Neuroscience Program, University Milano-Bicocca, via Cadore 48, 20900 Monza, Italy.
authors.forename: Marianna
authors.initials: M
authors.lastname: Monfrini
authors.affiliation: Experimental Neurology Unit and Milan Center for Neuroscience, School of Medicine and Surgery, University Milano-Bicocca, Via Cadore 48, 20900 Monza, Italy.
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Donzelli
authors.affiliation: Experimental Neurology Unit and Milan Center for Neuroscience, School of Medicine and Surgery, University Milano-Bicocca, Via Cadore 48, 20900 Monza, Italy.
authors.forename: Virginia
authors.initials: V
authors.lastname: Rodriguez-Menendez
authors.affiliation: Experimental Neurology Unit and Milan Center for Neuroscience, School of Medicine and Surgery, University Milano-Bicocca, Via Cadore 48, 20900 Monza, Italy.
authors.forename: Elisa
authors.initials: E
authors.lastname: Ballarini
authors.affiliation: Experimental Neurology Unit and Milan Center for Neuroscience, School of Medicine and Surgery, University Milano-Bicocca, Via Cadore 48, 20900 Monza, Italy.
authors.forename: Valentina Alda
authors.initials: VA
authors.lastname: Carozzi
authors.affiliation: Experimental Neurology Unit and Milan Center for Neuroscience, School of Medicine and Surgery, University Milano-Bicocca, Via Cadore 48, 20900 Monza, Italy.
authors.forename: Alessia
authors.initials: A
authors.lastname: Chiorazzi
authors.affiliation: Experimental Neurology Unit and Milan Center for Neuroscience, School of Medicine and Surgery, University Milano-Bicocca, Via Cadore 48, 20900 Monza, Italy.
authors.forename: Cristina
authors.initials: C
authors.lastname: Meregalli
authors.affiliation: Experimental Neurology Unit and Milan Center for Neuroscience, School of Medicine and Surgery, University Milano-Bicocca, Via Cadore 48, 20900 Monza, Italy.
authors.forename: Annalisa
authors.initials: A
authors.lastname: Canta
authors.affiliation: Experimental Neurology Unit and Milan Center for Neuroscience, School of Medicine and Surgery, University Milano-Bicocca, Via Cadore 48, 20900 Monza, Italy.
authors.forename: Norberto
authors.initials: N
authors.lastname: Oggioni
authors.affiliation: Istovet, Laboratorio di Analisi Istopatologiche Veterinarie e Servizi per la Ricerca Scientifica, Besana Brianza (MB), Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Crippa
authors.affiliation: Experimental Neurology Unit and Milan Center for Neuroscience, School of Medicine and Surgery, University Milano-Bicocca, Via Cadore 48, 20900 Monza, Italy.
authors.forename: Federica
authors.initials: F
authors.lastname: Avezza
authors.affiliation: Department of Biomedical Engineering, IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, 24126 Bergamo, Italy.
authors.forename: Sara
authors.initials: S
authors.lastname: Silvani
authors.affiliation: Department of Biomedical Engineering, IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, 24126 Bergamo, Italy.
authors.forename: Barbara
authors.initials: B
authors.lastname: Bonandrini
authors.affiliation: Department of Biomedical Engineering, IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, 24126 Bergamo, Italy.
authors.forename: Marina
authors.initials: M
authors.lastname: Figliuzzi
authors.affiliation: Department of Biomedical Engineering, IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, 24126 Bergamo, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Remuzzi
authors.affiliation: Neuroalgology and Headache Unit, IRCCS Foundation, Carlo Besta Neurological Institute, Milan, Italy.
authors.forename: Carla
authors.initials: C
authors.lastname: Porretta-Serapiglia
authors.affiliation: Neuroalgology and Headache Unit, IRCCS Foundation, Carlo Besta Neurological Institute, Milan, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Bianchi
authors.affiliation: Neuroalgology and Headache Unit, IRCCS Foundation, Carlo Besta Neurological Institute, Milan, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Lauria
authors.affiliation: Experimental Neurology Unit and Milan Center for Neuroscience, School of Medicine and Surgery, University Milano-Bicocca, Via Cadore 48, 20900 Monza, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Tredici
authors.affiliation: Experimental Neurology Unit and Milan Center for Neuroscience, School of Medicine and Surgery, University Milano-Bicocca, Via Cadore 48, 20900 Monza, Italy.
authors.forename: Guido
authors.initials: G
authors.lastname: Cavaletti
authors.affiliation: Experimental Neurology Unit and Milan Center for Neuroscience, School of Medicine and Surgery, University Milano-Bicocca, Via Cadore 48, 20900 Monza, Italy. Electronic address: arianna.scuteri@unimib.it.
authors.forename: Arianna
authors.initials: A
authors.lastname: Scuteri
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D003929:Diabetic Neuropathies / Q000097:blood / Q000503:physiopathology / Q000601:surgery* / Q000628:therapy*; D004195:Disease Models, Animal; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000502:physiology*; D009413:Nerve Fibers, Myelinated / Q000473:pathology; D009431:Neural Conduction / Q000187:drug effects; D017288:Pain Threshold / Q000187:drug effects; D010179:Pancreas / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D017208:Rats, Wistar; D013311:Streptozocin / Q000494:pharmacology; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
chemical_list: D000903:Antibiotics, Antineoplastic; D001786:Blood Glucose; D017392:Thiobarbituric Acid Reactive Substances; D013311:Streptozocin
keywords: Diabetes; Diabetic neuropathy; Mesenchymal stem cell; Pancreatic islet transplantation