title: Monocyte-derived dendritic cells enhance protection against secondary influenza challenge by controlling the switch in CD8+T-cell immunodominance.
abstract: Influenza virus infection triggers an increase in the number of monocyte-derived dendritic cells (moDCs) in the respiratory tract, but the role of these cells during antiviral immunity is still unclear. Here we show that during influenza infection, moDCs dominate the late activation of CD8+T cells and trigger the switch in immunodominance of the CD8+T-cell response from acidic polymerase specificity to nucleoprotein specificity. Abrogation of monocyte recruitment or depletion of moDCs strongly compromised host resistance to secondary influenza challenge. These findings underscore a novel function of moDCs in the antiviral response to influenza virus, and have important implications for vaccine design.
authors.affiliation: Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany.
authors.forename: Jazmina L G
authors.initials: JL
authors.lastname: Cruz
authors.affiliation: Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany.
authors.forename: José V
authors.initials: JV
authors.lastname: Pérez-Girón
authors.affiliation: Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany.|Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.|German Center for Infection Research (DZIF), Partner Site Hamburg, Hamburg, Germany.
authors.forename: Anja
authors.initials: A
authors.lastname: Lüdtke
authors.affiliation: Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany.
authors.forename: Sergio
authors.initials: S
authors.lastname: Gómez-Medina
authors.affiliation: Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany.|Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.|German Center for Infection Research (DZIF), Partner Site Hamburg, Hamburg, Germany.
authors.forename: Paula
authors.initials: P
authors.lastname: Ruibal
authors.affiliation: Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA.
authors.forename: Juliana
authors.initials: J
authors.lastname: Idoyaga
authors.affiliation: Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany.|Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.|German Center for Infection Research (DZIF), Partner Site Hamburg, Hamburg, Germany.
authors.forename: César
authors.initials: C
authors.lastname: Muñoz-Fontela
mesh_terms: D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D002478:Cells, Cultured; D003713:Dendritic Cells / Q000276:immunology* / Q000821:virology; D016056:Immunodominant Epitopes / Q000276:immunology; D007156:Immunologic Memory; D053118:Influenza A Virus, H1N1 Subtype / Q000276:immunology*; D008168:Lung / Q000276:immunology* / Q000821:virology; D008213:Lymphocyte Activation; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D008822:Mice, Transgenic; D009000:Monocytes / Q000276:immunology*; D009976:Orthomyxoviridae Infections / Q000276:immunology*; D037182:T-Cell Antigen Receptor Specificity; D014758:Viral Core Proteins / Q000276:immunology
chemical_list: D016056:Immunodominant Epitopes; D014758:Viral Core Proteins
keywords: CD8+ T cell · Dendritic cell · Immunodominance · Influenza virus · Monocyte