title: Development of a platelet adhesion transport equation for a computational thrombosis model.
abstract: Thrombosis is a significant issue for cardiovascular device development and use. While thrombosis models are available, very few are device-related and none have been thoroughly validated experimentally. Here, we introduce a surface adherent platelet transport equation into a continuum model to account for the biomaterial interface/blood interaction. Using a rotating disc system and polyurethane-urea material, we characterize steady and pulsatile flow fields using laser Doppler velocimetry. In vitro measurements of platelet adhesion are used in combination with the LDV data to provide further experimental validation. The rotating disc system is computationally studied using the device-induced thrombosis model with the surface platelet adherent transport equation. The results indicate that the flow field is in excellent agreement to the experimental LDV data and that the platelet adhesion simulations are in good agreement with the in vitro platelet data. These results provide good evidence that this transport equation can be used to express the relationship between blood and a biomaterial if the correct platelet adhesion characteristics are known for the biomaterial. Further validation is necessary with other materials.
authors.affiliation: Department of Biomedical Engineering, The Pennsylvania State University, University Park, PA, USA; Applied Research Laboratory, The Pennsylvania State University, State College, PA, USA.
authors.forename: Joshua O
authors.initials: JO
authors.lastname: Taylor
authors.affiliation: Department of Biomedical Engineering, The Pennsylvania State University, University Park, PA, USA.
authors.forename: Ling
authors.initials: L
authors.lastname: Yang
authors.affiliation: Applied Research Laboratory, The Pennsylvania State University, State College, PA, USA.
authors.forename: Steven
authors.initials: S
authors.lastname: Deutsch
authors.affiliation: Department of Biomedical Engineering, The Pennsylvania State University, University Park, PA, USA; Department of Surgery, Penn State Hershey Medical Center, Hershey, PA, USA. Electronic address: kbm10@psu.edu.
authors.forename: Keefe B
authors.initials: KB
authors.lastname: Manning
mesh_terms: D000465:Algorithms; D001792:Blood Platelets / Q000502:physiology*; D002448:Cell Adhesion; D003198:Computer Simulation; D006801:Humans; D017078:Laser-Doppler Flowmetry; D008955:Models, Cardiovascular; D010973:Platelet Adhesiveness; D011673:Pulsatile Flow; D013927:Thrombosis / Q000473:pathology*
keywords: Adhesion; Computations; Laser Doppler velocimetry; Modeling; Platelets; Thrombosis