title: Thyroid Langerhans cell histiocytosis and papillary thyroid carcinoma.
abstract: A 27-year-old female, married with two children, presented to our clinic with a 1-year history of thyroid swelling and pressure symptoms on lying backward and bilateral cervical lymphadenopathy. The patient was a known case of panhypopituitarism for 5 years. Comprehensive patient evaluation including FNAC with papillary thyroid cancer result then she underwent total thyroidectomy and bilateral neck dissection and final histologic examination confirmed papillary thyroid carcinoma in the background of lymphocytic thyroiditis, associated with Langerhans cell histiocytosis (LCH). The draining cervical lymph nodes were also involved by LCH and metastatic papillary thyroid carcinoma. Although the association of LCH with papillary thyroid carcinoma in the thyroid has been reported, their co-existence with LCH in the draining lymph nodes is very uncommon.
authors.affiliation: Department of Surgery, Otolaryngology Head and Neck Division, Faculty of Medicine, Al-Baha University, Al-Baha, Saudi Arabia.
authors.forename: Rajab
authors.initials: R
authors.lastname: AlZahrani
authors.affiliation: Department of Otolaryngology, Head & Neck, King Saud Ibn AbullAziz University for Health Science, & King AbdulAziz Medical City, National Guard Hospital, Jeddah, Saudi Arabia.
authors.forename: Mohammed
authors.initials: M
authors.lastname: Algarni
authors.affiliation: Department of Otolaryngology, Head & Neck, King Saud Ibn AbullAziz University for Health Science, & King AbdulAziz Medical City, National Guard Hospital, Jeddah, Saudi Arabia.
authors.forename: Hadi
authors.initials: H
authors.lastname: Alhakami
authors.affiliation: Otolaryngology Department, National Gaurd Hospital, King AbullAziz Medical City, Jeddah, Saudi Arabia.
authors.forename: Haia
authors.initials: H
authors.lastname: AlSubayea
authors.affiliation: Otolaryngology Department, National Gaurd Hospital, King AbullAziz Medical City, Jeddah, Saudi Arabia.
authors.forename: Naif
authors.initials: N
authors.lastname: Alfattani
authors.affiliation: Histopathology Department, National Gaurd Hospital, King AbullAziz Medical City, Jeddah, Saudi Arabia.
authors.forename: Mohammet
authors.initials: M
authors.lastname: Guler
authors.affiliation: Histopathology Department, National Gaurd Hospital, King AbullAziz Medical City, Jeddah, Saudi Arabia.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Satti
keywords: Langerhans cell histiocytosis (LCH); panhypopituitarism; papillary thyroid carcinoma (PTC)