title: Management of Acute Hepatotoxicity Including Medical Agents and Liver Support Systems.
abstract: Drug-induced liver injury (DILI) can be predictable or idiosyncratic and has an estimated incidence of approximately 20 cases per 100,000 persons per year. DILI is a common cause of acute liver failure in the United States. No accurate tests for diagnosing DILI exist, and its diagnosis is based on exclusion of other conditions. Managing DILI includes discontinuing the suspected causative agent and in selected cases administering an antidote. Liver support systems are used for long-term support or as a bridge to transplantation and are effective for improving encephalopathy, hyperbilirubinemia, and other liver-related conditions, but whether they improve survival remains uncertain.
authors.affiliation: Department of Transplant Surgery/Center of Advanced Liver Disease, Methodist University Hospital, University of Tennessee Health Science Center, 1211 Union Avenue, Suite 340, Memphis, TN 38104, USA.
authors.forename: Humberto C
authors.initials: HC
authors.lastname: Gonzalez
authors.affiliation: Division of Gastroenterology and Hepatology, Henry Ford Health System, 2799 West Grand Boulevard, Detroit, MI 48202, USA.
authors.forename: Syed-Mohammed
authors.initials: SM
authors.lastname: Jafri
authors.affiliation: Division of Gastroenterology and Hepatology, Henry Ford Health System, 2799 West Grand Boulevard, Detroit, MI 48202, USA. Electronic address: sgordon3@hfhs.org.
authors.forename: Stuart C
authors.initials: SC
authors.lastname: Gordon
mesh_terms: D000931:Antidotes / Q000008:administration & dosage*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology / Q000401:mortality / Q000503:physiopathology / Q000628:therapy*; D018450:Disease Progression; D005260:Female; D006440:Hemofiltration / Q000379:methods; D006801:Humans; D017114:Liver Failure, Acute / Q000401:mortality* / Q000503:physiopathology / Q000628:therapy*; D019164:Liver, Artificial; D008297:Male; D011379:Prognosis; D018570:Risk Assessment; D012720:Severity of Illness Index; D016019:Survival Analysis; D016896:Treatment Outcome; D028761:Withholding Treatment
chemical_list: D000931:Antidotes
keywords: Acute liver failure; Artificial liver support systems; Bioartificial liver support systems; Drug-induced liver injury; Liver support systems