title: 1,5-Diazacyclooctanes, as Exclusive Oxidative Polyamine Metabolites, Inhibit Amyloid-β(1-40) Fibrillization.
abstract: Biologically relevant 1,5-diazacyclooctanesderived from polyamines and acrolein, inhibit Aβ40 peptide fibrillization and significantly suppress cell cytotoxicity. Formal [4+4] cycloaddition reaction of imines is thus involved in modulating oxidative stress processes associated with neural diseases.
authors.affiliation: Biofunctional Synthetic Chemistry Laboratory RIKEN Hirosawa, Wako-shi Saitama 351-0198 Japan.
authors.forename: Ayumi
authors.initials: A
authors.lastname: Tsutsui
authors.affiliation: Bioengineering Laboratory RIKEN Hirosawa, Wako-shi Saitama 351-0198 Japan.
authors.forename: Tamotsu
authors.initials: T
authors.lastname: Zako
authors.affiliation: Bioengineering Laboratory RIKEN Hirosawa, Wako-shi Saitama 351-0198 Japan.
authors.forename: Tong
authors.initials: T
authors.lastname: Bu
authors.affiliation: Systems Glycobiology Research Group RIKEN-Max Plank Joint Research Center for Systems Chemical Biology RIKEN Global Research Cluster RIKEN Hirosawa, Wako-shi Saitama 351-0198 Japan.
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Yamaguchi
authors.affiliation: Bioengineering Laboratory RIKEN Hirosawa, Wako-shi Saitama 351-0198 Japan.
authors.forename: Mizuo
authors.initials: M
authors.lastname: Maeda
authors.affiliation: Biofunctional Synthetic Chemistry Laboratory RIKEN Hirosawa, Wako-shi Saitama 351-0198 Japan; Biofunctional Chemistry Laboratory A. Butlerov Institute of Chemistry Kazan Federal University 18  Kremlyovskaya Street Kazan 420008 Russia; JST-PRESTO Hirosawa, Wako-shi Saitama 351-0198 Japan.
authors.forename: Katsunori
authors.initials: K
authors.lastname: Tanaka
keywords: acrolein; amyloid; cycloaddition; oxidative stress; polyamine