title: Induction chemotherapy with docetaxel, cisplatin and fluorouracil followed by concurrent chemoradiotherapy or chemoradiotherapy alone in locally advanced non-endemic nasopharyngeal carcinoma.
abstract: To evaluate the efficacy of induction chemotherapy with docetaxel, cisplatin and fluorouracil (TPF) followed by concurrent chemoradiotherapy (IC+CCRT) or CCRT alone in non-endemic locally advanced nasopharyngeal carcinoma (NPC) patients.
  
  
  
  Data of 106 patients with NPC treated from January 1999 to June 2012 with IC+CCRT (n=58) or CCRT alone (n=48) were retrospectively reviewed.
  
  
  
  Median follow-up was 6.4years. Distribution of age, performance status, stage and concurrent chemotherapy regimen were imbalanced between the two groups. The 5-year overall survival (OS) and progression-free survival (PFS) were not significantly different between IC+CCRT and CCRT groups (OS: 78.3% vs. 82.7%, p=0.77; PFS: 72.5% vs. 68.2%, p=0.81, respectively). There were less total cumulative incidence of grade 3-4 late radiation morbidity in the IC+CCRT group (44.8% vs. 70.8%, p=0.01). Five-year OS for patients with post-IC complete response (CR), partial response (PR) and stable disease (SD) sub-groups were 100%, 79.4% and 60%, respectively.
  
  
  
  Compared with CCRT alone, IC (TPF regimen)+CCRT did not improve OS or PFS in patients with NPC, but less grade 3-4 late toxicities were observed. Responsiveness of IC may provide additional prognostic information.
authors.affiliation: Department of Radiation Oncology, Gustave Roussy, Paris-Saclay University, Villejuif, France; Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Ou
authors.affiliation: Department of Radiation Oncology, Gustave Roussy, Paris-Saclay University, Villejuif, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Blanchard
authors.affiliation: Department of Radiation Oncology, Gustave Roussy, Paris-Saclay University, Villejuif, France.
authors.forename: Clément
authors.initials: C
authors.lastname: El Khoury
authors.affiliation: Department of Radiation Oncology, Gustave Roussy, Paris-Saclay University, Villejuif, France.
authors.forename: Francesca
authors.initials: F
authors.lastname: De Felice
authors.affiliation: Department of Head and Neck Oncology, Gustave Roussy, Paris-Saclay University, Villejuif, France.
authors.forename: Caroline
authors.initials: C
authors.lastname: Even
authors.affiliation: Department of Radiation Oncology, Gustave Roussy, Paris-Saclay University, Villejuif, France.
authors.forename: Antonin
authors.initials: A
authors.lastname: Levy
authors.affiliation: Department of Radiation Oncology, Gustave Roussy, Paris-Saclay University, Villejuif, France.
authors.forename: France
authors.initials: F
authors.lastname: Nguyen
authors.affiliation: Department of Head and Neck Oncology, Gustave Roussy, Paris-Saclay University, Villejuif, France.
authors.forename: François
authors.initials: F
authors.lastname: Janot
authors.affiliation: Department of Head and Neck Oncology, Gustave Roussy, Paris-Saclay University, Villejuif, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Gorphe
authors.affiliation: Department of Radiation Oncology, Gustave Roussy, Paris-Saclay University, Villejuif, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Deutsch
authors.affiliation: Department of Head and Neck Oncology, Gustave Roussy, Paris-Saclay University, Villejuif, France.
authors.forename: Stephane
authors.initials: S
authors.lastname: Temam
authors.affiliation: Department of Radiation Oncology, Gustave Roussy, Paris-Saclay University, Villejuif, France. Electronic address: yungan.tao@gustaveroussy.fr.
authors.forename: Yungan
authors.initials: Y
authors.lastname: Tao
mesh_terms: D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002277:Carcinoma / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D059248:Chemoradiotherapy; D002945:Cisplatin / Q000008:administration & dosage; D000077143:Docetaxel; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008875:Middle Aged; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D011379:Prognosis; D043823:Taxoids / Q000008:administration & dosage
chemical_list: D043823:Taxoids; D000077143:Docetaxel; D002945:Cisplatin; D005472:Fluorouracil
keywords: Concurrent chemoradiotherapy; Induction chemotherapy; Nasopharyngeal carcinoma