title: Gut hormones and gut microbiota: implications for kidney function and hypertension.
abstract: Increased blood pressure (BP) and chronic kidney disease are two leading risk factors for cardiovascular disease. Increased sodium intake is one of the most important risk factors for development of hypertension. Recent data have shown that gut influences kidney function and BP by variety of mechanisms. Various hormones and peptides secreted from gut such as gastrin, glucocorticoids, Glucagon-like peptide-1 impact on kidney function and BP especially influencing sodium absorption from gut. These findings stimulate scientist to find new therapeutic options such as tenapanor for treatment of hypertension by blocking sodium absorption from gut. The gastrointestinal tract is also occupied by a huge community of microbes (microbiome) that under normal condition has a symbiotic relationship with the host. Alterations in the structure and function of the gut microbiota have been shown to play a key role in the pathogenesis and complications of numerous diseases including hypertension. Based on these data, in this review, we provide a summary of the available data on the role of gut and gut microbiota in regulation of BP and kidney function.
authors.affiliation: Division of Nephrology, Department of Medicine, Konya Numune State Hospital, Konya, Turkey.
authors.forename: Baris
authors.initials: B
authors.lastname: Afsar
authors.affiliation: Division of Nephrology and Hypertension, Department of Medicine, Schools of Medicine and Biological Science, University of California, Irvine, CA, USA.
authors.forename: Nosratola D
authors.initials: ND
authors.lastname: Vaziri
authors.affiliation: Department of Cardiology, Koc University School of Medicine, Istanbul, Turkey.
authors.forename: Gamze
authors.initials: G
authors.lastname: Aslan
authors.affiliation: Department of Medicine, Koc University School of Medicine, Istanbul, Turkey.
authors.forename: Kayhan
authors.initials: K
authors.lastname: Tarim
authors.affiliation: Division of Nephrology, Department of Medicine, Koc University School of Medicine, Istanbul, Turkey. Electronic address: mkanbay@ku.edu.tr.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Kanbay
mesh_terms: D001794:Blood Pressure; D002318:Cardiovascular Diseases / Q000209:etiology; D005768:Gastrointestinal Hormones / Q000378:metabolism*; D000069196:Gastrointestinal Microbiome; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology*; D007408:Intestinal Absorption / Q000187:drug effects; D007422:Intestines / Q000187:drug effects / Q000382:microbiology / Q000502:physiology*; D007546:Isoquinolines / Q000627:therapeutic use; D051436:Renal Insufficiency, Chronic / Q000150:complications / Q000503:physiopathology*; D012982:Sodium, Dietary / Q000009:adverse effects / Q000378:metabolism*; D013449:Sulfonamides / Q000627:therapeutic use
chemical_list: D005768:Gastrointestinal Hormones; D007546:Isoquinolines; D012982:Sodium, Dietary; D013449:Sulfonamides; C000599417:tenapanor
keywords: Intestinal hormones; Na+/H+ exchanger-3; kidney disease; microbiota