title: Mechanisms of action of Rab proteins, key regulators of intracellular vesicular transport.
abstract: Our understanding of the manner in which Rab proteins regulate intracellular vesicular transport has progressed remarkably in the last one or two decades by application of a wide spectrum of biochemical, biophysical and cell biological methods, augmented by the methods of chemical biology. Important additional insights have arisen from examination of the manner in which certain bacteria can manipulate vesicular transport mechanisms. The progress in these areas is summarized here.
authors.affiliation: Department of Structural Biochemistry, Max Planck Institute of Molecular Physiology, Otto-Hahn-Straße 11, D-44227 Dortmund.
authors.forename: Roger Sidney
authors.initials: RS
authors.lastname: Goody
authors.affiliation: Department of Structural Biochemistry, Max Planck Institute of Molecular Physiology, Otto-Hahn-Straße 11, D-44227 Dortmund.
authors.forename: Matthias Philipp
authors.initials: MP
authors.lastname: Müller
authors.affiliation: Chemical Genomics Centre of the Max Planck Society, D-44227 Dortmund.
authors.forename: Yao-Wen
authors.initials: YW
authors.lastname: Wu
mesh_terms: D001419:Bacteria / Q000166:cytology / Q000378:metabolism; D006801:Humans; D022161:Transport Vesicles / Q000378:metabolism*; D020691:rab GTP-Binding Proteins / Q000737:chemistry / Q000378:metabolism*
chemical_list: D020691:rab GTP-Binding Proteins
keywords: GAPs; GEFs; GTPases; Legionella; Rabs; effectors; targeting