title: Rhinophototherapy in persistent allergic rhinitis.
abstract: Previous published results have revealed that Rhinolight®intranasal phototherapy is safe and effective in intermittent allergic rhinitis. The present objective was to assess whether phototherapy is also safe and effective in persistent allergic rhinitis. Thirty-four patients with persistent allergic rhinitis were randomized into two groups; twenty-five subjects completed the study. The Rhinolight®group was treated with a combination of UV-B, UV-A, and high-intensity visible light, while the placebo group received low-intensity visible white light intranasal phototherapy on a total of 13 occasions in 6 weeks. The assessment was based on the diary of symptoms, nasal inspiratory peak flow, quantitative smell threshold, mucociliary transport function, and ICAM-1 expression of the epithelial cells. All nasal symptom scores and nasal inspiratory peak flow measurements improved significantly in the Rhinolight®group relative to the placebo group and this finding persisted after 4 weeks of follow-up. The smell and mucociliary functions did not change significantly in either group. The number of ICAM-1 positive cells decreased non-significantly in the Rhinolight®group. No severe side-effects were reported during the treatment period. These results suggest that Rhinolight®treatment is safe and effective in persistent allergic rhinitis.
authors.affiliation: Department of Otorhinolarygology and Head and Neck Surgery, Faculty of Medicine, University of Szeged, Tisza Lajos krt 111, Szeged, 6725, Hungary. dr.bella.zsolt@gmail.com.
authors.forename: Zsolt
authors.initials: Z
authors.lastname: Bella
authors.affiliation: Department of Otorhinolarygology and Head and Neck Surgery, Faculty of Medicine, University of Szeged, Tisza Lajos krt 111, Szeged, 6725, Hungary.
authors.forename: Ágnes
authors.initials: Á
authors.lastname: Kiricsi
authors.affiliation: Department of Dermatology and Allergology, Faculty of Medicine, University of Szeged, Korányi fasor 6, Szeged, 6720, Hungary.
authors.forename: Éva Dósa-Rácz
authors.initials: ÉD
authors.lastname: Viharosné
authors.affiliation: Department of Dermatology and Allergology, Faculty of Medicine, University of Szeged, Korányi fasor 6, Szeged, 6720, Hungary.
authors.forename: Attila
authors.initials: A
authors.lastname: Dallos
authors.affiliation: Department of Otorhinolarygology and Head and Neck Surgery, Faculty of Medicine, University of Szeged, Tisza Lajos krt 111, Szeged, 6725, Hungary.
authors.forename: Ádám
authors.initials: Á
authors.lastname: Perényi
authors.affiliation: Department of Dermatology and Allergology, Faculty of Medicine, University of Szeged, Korányi fasor 6, Szeged, 6720, Hungary.
authors.forename: Mária
authors.initials: M
authors.lastname: Kiss
authors.affiliation: Department of Dermatology and Allergology, Faculty of Medicine, University of Szeged, Korányi fasor 6, Szeged, 6720, Hungary.
authors.forename: Andrea
authors.initials: A
authors.lastname: Koreck
authors.affiliation: Department of Dermatology and Allergology, Faculty of Medicine, University of Szeged, Korányi fasor 6, Szeged, 6720, Hungary.
authors.forename: Lajos
authors.initials: L
authors.lastname: Kemény
authors.affiliation: Department of Otorhinolarygology and Head and Neck Surgery, Faculty of Medicine, University of Szeged, Tisza Lajos krt 111, Szeged, 6725, Hungary.
authors.forename: József
authors.initials: J
authors.lastname: Jóri
authors.affiliation: Department of Otorhinolarygology and Head and Neck Surgery, Faculty of Medicine, University of Szeged, Tisza Lajos krt 111, Szeged, 6725, Hungary.
authors.forename: László
authors.initials: L
authors.lastname: Rovó
authors.affiliation: Department of Otorhinolarygology and Head and Neck Surgery, Faculty of Medicine, University of Szeged, Tisza Lajos krt 111, Szeged, 6725, Hungary.
authors.forename: Edit
authors.initials: E
authors.lastname: Kadocsa
mesh_terms: D000281:Administration, Intranasal; D000328:Adult; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009079:Mucociliary Clearance; D009297:Nasal Mucosa / Q000378:metabolism; D010789:Phototherapy / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods; D012129:Respiratory Function Tests / Q000379:methods; D065631:Rhinitis, Allergic / Q000175:diagnosis / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy; D063189:Symptom Assessment / Q000379:methods; D016896:Treatment Outcome
chemical_list: D018799:Intercellular Adhesion Molecule-1
keywords: Intercellular adhesion molecule-1 expression; Intranasal phototherapy; Mucociliary clearance; Nasal inspiratory peak flow; Persistent allergic rhinitis; Rhinolight®