title: [The expression and clinical significance of IL-35 in periodontitis and oral lichen planus].
abstract: OBJECTIVE
  To investigate the influence of IL-35 in the pathogenesis of periodontitis and oral lichen planus, and the correlation between periodontitis and oral lichen planus patients.
  
  
  METHODS
  The gingival crevicular fluid（GCF） and serum were collected from patients with oral lichen planus (n=20), periodontitis (n=20), periodontitis and oral lichen planus (n=20) and healthy controls (n=12). The patients' basic information, probing depth, clinical attachment loss, gingival index, sulcus bleeding index were measured and collected. The expression of IL-35 in GCF and serum was detected by ELISA. SPSS19.0 software package was used for statistical analysis.
  
  
  RESULTS
  The concentration of IL-35 in patients with periodontitis and oral lichen planus was significantly higher than that of other groups(P<0.05). There was significantly positive correlation between IL-35 level and periodontal clinical parameters.
  
  
  CONCLUSIONS
  Periodontitis and oral lichen planus may increase the concentration of IL-35 both in serum and GCF. The expression of IL-35 was positively correlated with periodontitis and oral lichen planus.
authors.affiliation: Department of Stomatology, Shengjing Hospital of China Medical University. Shenyang 110004, Liaoning Province, China. E-mail:wangyu995887101@126.com.
authors.forename: Yu
authors.initials: Y
authors.lastname: Wang
authors.forename: Ying
authors.initials: Y
authors.lastname: Jin
authors.forename: Yi-Yue
authors.initials: YY
authors.lastname: Wang
authors.forename: Dan-Ni
authors.initials: DN
authors.lastname: Xu
authors.forename: Xiao-Ping
authors.initials: XP
authors.lastname: Lin
mesh_terms: D004797:Enzyme-Linked Immunosorbent Assay; D005883:Gingival Crevicular Fluid; D006801:Humans; D007378:Interleukins; D017676:Lichen Planus, Oral; D010512:Periodontal Index; D010518:Periodontitis
chemical_list: D007378:Interleukins; C532417:interleukin-35, human