title: Abnormal visuomotor processing in schizophrenia.
abstract: Subtle disturbances of visual and motor function are known features of schizophrenia and can greatly impact quality of life; however, few studies investigate these abnormalities using simple visuomotor stimuli. In healthy people, electrophysiological data show that beta band oscillations in sensorimotor cortex decrease during movement execution (event-related beta desynchronisation (ERBD)), then increase above baseline for a short time after the movement (post-movement beta rebound (PMBR)); whilst in visual cortex, gamma oscillations are increased throughout stimulus presentation. In this study, we used a self-paced visuomotor paradigm and magnetoencephalography (MEG) to contrast these responses in patients with schizophrenia and control volunteers. We found significant reductions in the peak-to-peak change in amplitude from ERBD to PMBR in schizophrenia compared with controls. This effect was strongest in patients who made fewer movements, whereas beta was not modulated by movement in controls. There was no significant difference in the amplitude of visual gamma between patients and controls. These data demonstrate that clear abnormalities in basic sensorimotor processing in schizophrenia can be observed using a very simple MEG paradigm.
authors.affiliation: Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, University Park, Nottingham NG7 2RD, UK.
authors.forename: Siân E
authors.initials: SE
authors.lastname: Robson
authors.affiliation: Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, University Park, Nottingham NG7 2RD, UK.
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Brookes
authors.affiliation: Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, University Park, Nottingham NG7 2RD, UK.
authors.forename: Emma L
authors.initials: EL
authors.lastname: Hall
authors.affiliation: Centre for Translational Neuroimaging in Mental Health, Institute of Mental Health, School of Medicine, University of Nottingham, Jubilee Campus, Triumph Road, Nottingham NG7 2TU, UK.
authors.forename: Lena
authors.initials: L
authors.lastname: Palaniyappan
authors.affiliation: Centre for Translational Neuroimaging in Mental Health, Institute of Mental Health, School of Medicine, University of Nottingham, Jubilee Campus, Triumph Road, Nottingham NG7 2TU, UK.
authors.forename: Jyothika
authors.initials: J
authors.lastname: Kumar
authors.affiliation: Centre for Translational Neuroimaging in Mental Health, Institute of Mental Health, School of Medicine, University of Nottingham, Jubilee Campus, Triumph Road, Nottingham NG7 2TU, UK.
authors.forename: Michael
authors.initials: M
authors.lastname: Skelton
authors.affiliation: Centre for Translational Neuroimaging in Mental Health, Institute of Mental Health, School of Medicine, University of Nottingham, Jubilee Campus, Triumph Road, Nottingham NG7 2TU, UK.
authors.forename: Nikolaos G
authors.initials: NG
authors.lastname: Christodoulou
authors.affiliation: Kevin White Unit, Smithdown Health Park, Smithdown Road, Liverpool L15 2HE, UK.
authors.forename: Ayaz
authors.initials: A
authors.lastname: Qureshi
authors.affiliation: Herschel Prins Centre, Glenfield Hospital, Leicestershire Partnership NHS Trust, Groby Road, Leicester LE3 9QP, UK.
authors.forename: Fiesal
authors.initials: F
authors.lastname: Jan
authors.affiliation: Centre for Translational Neuroimaging in Mental Health, Institute of Mental Health, School of Medicine, University of Nottingham, Jubilee Campus, Triumph Road, Nottingham NG7 2TU, UK.
authors.forename: Mohammad Z
authors.initials: MZ
authors.lastname: Katshu
authors.affiliation: Centre for Translational Neuroimaging in Mental Health, Institute of Mental Health, School of Medicine, University of Nottingham, Jubilee Campus, Triumph Road, Nottingham NG7 2TU, UK.
authors.forename: Elizabeth B
authors.initials: EB
authors.lastname: Liddle
authors.affiliation: Centre for Translational Neuroimaging in Mental Health, Institute of Mental Health, School of Medicine, University of Nottingham, Jubilee Campus, Triumph Road, Nottingham NG7 2TU, UK.
authors.forename: Peter F
authors.initials: PF
authors.lastname: Liddle
authors.affiliation: Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, University Park, Nottingham NG7 2RD, UK.
authors.forename: Peter G
authors.initials: PG
authors.lastname: Morris
mesh_terms: D000328:Adult; D058256:Brain Waves; D002540:Cerebral Cortex / Q000503:physiopathology*; D005260:Female; D006801:Humans; D015225:Magnetoencephalography; D008297:Male; D010775:Photic Stimulation; D011597:Psychomotor Performance; D012559:Schizophrenia / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D014796:Visual Perception / Q000502:physiology; D055815:Young Adult
keywords: Electrophysiological processes; Magnetoencephalography; Motor cortex; Schizophrenia; Visual cortex