title: [Clinical significance of calcitonin gene-related peptide level before and after treatment in patients with chronic periodontitis].
abstract: OBJECTIVE
  To explore the clinical significance of calcitonin gene-related peptide (CGRP) levels in patients with chronic periodontitis before and after treatment, and to detect the calcitonin gene-related peptide content in human venous blood.
  
  
  METHODS
  Thirty healthy controls and thirty patients with mild, moderate, severe periodontitis were enrolled from August 2014 to June 2015.CGRP level in the patients' peripheral blood was detected by ELISA. Three months after periodontal treatment, CGRP level in mild, moderate, severe periodontitis patients' peripheral blood was re-examined by ELISA. Then the correlation between calcitonin gene-related peptide and inflammation of chronic periodontitis was analyzed with SPSS 22.0 software package.
  
  
  RESULTS
  The content of CGRP in healthy controls was significantly higher than that in patients with periodontitis. With the aggravation of periodontal inflammation, blood level of CGRP decreased gradually, and the lowest was in patients with severe periodontitis (P<0.01). Three months after periodontal treatment, CGRP content was significantly higher compared with that before treatment (P<0.05), but no significant difference was found in patients with different degree of periodontitis (P>0.05).
  
  
  CONCLUSIONS
  The level of CGRP in venous blood decreased with the increasing severity of chronic periodontitis, and CGRP was negatively correlated with the degree of inflammation of chronic periodontitis. CGRP may be involved in the occurrence and development of chronic periodontitis. CGRP content in serum of patients with chronic periodontitis after treatment was significantly increased, CGRP may be used as the basis for clinical detection of chronic periodontitis.
authors.affiliation: Department of Periodontology, Stomatological Hospital of Chongqing Medical University. Chongqing 401147, China. E-mail:1436997194@qq.com.
authors.forename: Ying
authors.initials: Y
authors.lastname: Yan
authors.forename: Xue-Rong
authors.initials: XR
authors.lastname: Xiang
authors.forename: Chun
authors.initials: C
authors.lastname: Wang
authors.forename: Guo
authors.initials: G
authors.lastname: Ye
authors.forename: Xiao-Ping
authors.initials: XP
authors.lastname: Fan
mesh_terms: D002116:Calcitonin; D015740:Calcitonin Gene-Related Peptide; D016022:Case-Control Studies; D055113:Chronic Periodontitis; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans
chemical_list: D002116:Calcitonin; D015740:Calcitonin Gene-Related Peptide