title: The role of steroids in the prediction of affective disorders in adult men.
abstract: Anxiety and mood disorders (AMD) are the most frequent mental disorders in the human population. They have recently shown increasing prevalence, and commonly disrupt personal and working lives. The aim of our study was to analyze the spectrum of circulating steroids in order to discover differences that could potentially be markers of affective depression or anxiety, and identify which steroids could be a predictive component for these diseases.
  
  
  
  We studied the steroid metabolome including 47 analytes in 20 men with depression (group D), 20 men with anxiety (group AN) and 30 healthy controls. OPLS and multivariate regression models were used for statistical analysis.
  
  
  
  Discrimination of group D from controls by the OPLS method was absolute, as was group AN from controls (sensitivity=1.000 (0.839, 1.000), specificity=1.000 (0.887, 1.000)). Relatively good predictivity was also found for discrimination between group D from AN (sensitivity=0.850 (0.640, 0.948), specificity=0.900 (0.699, 0.972)).
  
  
  
  Selected circulating steroids, including those that are neuroactive and neuroprotective, can be useful tools for discriminating between these affective diseases in adult men.
authors.affiliation: Institute of Endocrinology, Prague, Czech Republic.
authors.forename: Monika
authors.initials: M
authors.lastname: Šrámková
authors.affiliation: Institute of Endocrinology, Prague, Czech Republic. Electronic address: mduskova@endo.cz.
authors.forename: Michaela
authors.initials: M
authors.lastname: Dušková
authors.affiliation: Institute of Endocrinology, Prague, Czech Republic.
authors.forename: Martin
authors.initials: M
authors.lastname: Hill
authors.affiliation: Institute of Endocrinology, Prague, Czech Republic.
authors.forename: Marie
authors.initials: M
authors.lastname: Bičíková
authors.affiliation: National Institute of Mental Health, Klecany, Czech Republic.
authors.forename: Daniela
authors.initials: D
authors.lastname: Řípová
authors.affiliation: National Institute of Mental Health, Klecany, Czech Republic.
authors.forename: Pavel
authors.initials: P
authors.lastname: Mohr
authors.affiliation: Institute of Endocrinology, Prague, Czech Republic.
authors.forename: Luboslav
authors.initials: L
authors.lastname: Stárka
mesh_terms: D000328:Adult; D001007:Anxiety / Q000097:blood; D003687:Dehydroepiandrosterone / Q000097:blood; D003863:Depression / Q000097:blood; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D008297:Male; D019964:Mood Disorders / Q000097:blood* / Q000175:diagnosis*; D015999:Multivariate Analysis; D011280:Pregnanolone / Q000097:blood; D011863:Radioimmunoassay; D013256:Steroids / Q000097:blood*; D055815:Young Adult
chemical_list: D013256:Steroids; D003687:Dehydroepiandrosterone; D011280:Pregnanolone
keywords: Affective depression; Allopregnanolone; Anxiety; Dehydroepiandrosterone; Multivariate analysis