title: Patents on Therapeutic and Cosmetic Applications of Bioactives of Crocus Sativus L. and their Production through Synthetic Biology Methods: A Review.
abstract: BACKGROUND
  Saffron (Crocus sativus L.) has a long history of use as a food additive and a traditional medicine for treating a number of disorders. Prominent bioactives of saffron are crocin, crocetin and safranal.
  
  
  OBJECTIVE
  The aim of this study was to carry out an extensive patent search to collect information on saffron bioactives and their derivatives as therapeutic and cosmeceutical agents. All patents related to the area of interest published globally till date have been reviewed. Moreover, a recent synthetic biology approach to cost effective and consistent production of saffron bioactives has been highlighted.
  
  
  METHODS
  A patent search strategy was designed based on keywords and concepts related to Crocus sativus L. and its bioactives- safranal, crocin and crocetin in combination with different patent classification codes relevant to the technology areas. This search strategy was employed to retrieve patents from various patent databases. The patents which focused on therapeutic or cosmetic applications and claimed compositions comprising crocin, crocetin or safranal as the main active component were selected and analysed.
  
  
  RESULTS
  Maximum patenting activity was noticed towards the use of these bioactives in the treatment of neurological disorders followed by multiple uses of the same compound, use in treatment of metabolic disorders and use as cosmeceuticals. Interestingly, there were no patent records related to use of these bioactives in treating infectious disorders.
  
  
  CONCLUSIONS
  Our patent analysis points out the populous and less explored uses of saffron bioactives and areas where there is further scope for research and growth. Recently developed synthetic biology approach is contributory in improving availability, consistency and cost effectiveness of saffron bioactives.
authors.affiliation: CSIR-Unit for Research and Development of Information Products, (CSIR-URDIP), Pune 411008, Maharashtra. India.
authors.forename: Mitali
authors.initials: M
authors.lastname: Dawalbhakta
authors.affiliation: CSIR-URDIP, Tapovan, S.No.113, 114, NCL Campus, Pashan, Pune 411008, Maharashtra. India.
authors.forename: Manasi
authors.initials: M
authors.lastname: Telang
mesh_terms: D000818:Animals; D001685:Biological Factors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002338:Carotenoids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D000068937:Cosmeceuticals / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D027622:Crocus / Q000737:chemistry*; D053138:Cyclohexenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D016208:Databases, Factual; D006801:Humans; D008659:Metabolic Diseases / Q000188:drug therapy*; D009422:Nervous System Diseases / Q000188:drug therapy*; D010330:Patents as Topic; D010936:Plant Extracts / Q000737:chemistry; D058615:Synthetic Biology / Q000379:methods; D013729:Terpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D014801:Vitamin A / Q000031:analogs & derivatives
chemical_list: D001685:Biological Factors; D000068937:Cosmeceuticals; D053138:Cyclohexenes; D010936:Plant Extracts; D013729:Terpenes; C487773:trans-sodium crocetinate; D014801:Vitamin A; D002338:Carotenoids; C087963:safranal; C029036:crocin
keywords: Saffron; anticancer; bioactives; metabolic disorder; neurological disorder; synthetic biology