title: Lipids and Adipokines in Cord Blood and at 72 h in Discordant Dichorionic Twins.
abstract: BACKGROUND
  Intrauterine growth restriction (IUGR) is a risk factor for developing metabolic syndrome later in life. We explored whether adipokine concentrations in cord blood (CB) and on day 3 (D3) were related to impaired fetal growth and lipids in IUGR twins.
  
  
  METHODS
  Thirty-six discordant (birth weight [BW] discordance ≥20% calculated in relation to the heavier co-twins) and 42 concordant (BW discordance ≤ 10%) twin pairs were included.
  
  
  RESULTS
  In IUGR twins, both adiponectin/BW and triglyceride (TG) levels were significantly higher, while total cholesterol, high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol were lower in CB. On D3, both leptin and HDL-C levels were significantly lower and TG levels were significantly higher in IUGR twins. In the discordant group, the alterations in lipids were not related to any adipokine.
  
  
  CONCLUSIONS
  IUGR is related to lower leptin level and proatherogenic lipid profile (higher TG and lower HDL-C), which are not influenced by adipokine at birth.
authors.affiliation: a Clinic for Gynecology and Obstetrics , Neonatology, Clinical Center of Serbia , Belgrade , Serbia.
authors.forename: Svetlana
authors.initials: S
authors.lastname: Milenković
authors.affiliation: b Institute for Mother and Child Health "Dr Vukan Čupić ," Belgrade , Serbia.|c School of Medicine , University of Belgrade , Belgrade , Serbia.
authors.forename: Borisav
authors.initials: B
authors.lastname: Jankovic
authors.affiliation: c School of Medicine , University of Belgrade , Belgrade , Serbia.|d Clinic for Gynecology and Obstetrics , Perinatology, School of Medicine, Clinical Center of Serbia , Belgrade , University of Belgrade.
authors.forename: Ljiljana
authors.initials: L
authors.lastname: Mirković
authors.affiliation: a Clinic for Gynecology and Obstetrics , Neonatology, Clinical Center of Serbia , Belgrade , Serbia.
authors.forename: Miljana Z
authors.initials: MZ
authors.lastname: Jovandaric
authors.affiliation: e Center for Anesthesia and Resuscitation , Clinical Center of Serbia , Belgrade , Serbia.
authors.forename: Dušan
authors.initials: D
authors.lastname: Milenković
authors.affiliation: a Clinic for Gynecology and Obstetrics , Neonatology, Clinical Center of Serbia , Belgrade , Serbia.
authors.forename: Biljana
authors.initials: B
authors.lastname: Otašević
mesh_terms: D054392:Adipokines / Q000378:metabolism*; D000328:Adult; D001724:Birth Weight / Q000502:physiology; D004200:Diseases in Twins / Q000097:blood / Q000175:diagnosis*; D005260:Female; D005312:Fetal Blood / Q000378:metabolism*; D047109:Fetal Development / Q000502:physiology; D005317:Fetal Growth Retardation / Q000097:blood; D006801:Humans; D020738:Leptin / Q000378:metabolism; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011247:Pregnancy; D059285:Pregnancy, Twin / Q000502:physiology*
chemical_list: D054392:Adipokines; D020738:Leptin; D008055:Lipids
keywords: Cord blood; IUGR; adiponectin; fetal programming; leptin; lipids