title: Antimicrobial Activity of Zabofloxacin against Clinically Isolated Streptococcus pneumoniae.
abstract: Zabofloxacin is a novel fluoroquinolone agent that has potent activity against gram-positive pathogens. In this study, we confirmed that zabofloxacin showed the most potent in vitro and in vivo activities against drug-resistantStreptococcus pneumoniae. Among the fluoroquinolone compounds, zabofloxacin showed the most potent in vitro activity against clinical isolates of penicillin-sensitiveS. pneumoniae(minimum inhibitory concentration, MIC90: 0.03 mg/L) and penicillin-resistantS. pneumoniae(MIC90: 0.03 mg/L). Against quinolone-resistantS. pneumoniae,zabofloxacin (MIC90: 1 mg/L) was more active than ciprofloxacin, sparfloxacin, and moxifloxacin; however, its activity was the same as that of gemifloxacin. The in vivo activity of zabofloxacin was most potent among the quinolone compounds tested against the systemic infection and respiratory tract infection models in mice.
authors.affiliation: School of Food Science and Biotechnology, Kyungpook National University, Daegu 41566, Korea. phsoo97@knu.ac.kr.
authors.forename: Hee-Soo
authors.initials: HS
authors.lastname: Park
authors.affiliation: School of Life Science, Handong Global University, 558 Handong-ro, Buk-gu, Pohang 37554, Korea. osh8755@naver.com.
authors.forename: Sang-Hun
authors.initials: SH
authors.lastname: Oh
authors.affiliation: School of Life Science, Handong Global University, 558 Handong-ro, Buk-gu, Pohang 37554, Korea. momobile217@gmail.com.
authors.forename: Hye-Shin
authors.initials: HS
authors.lastname: Kim
authors.affiliation: Dong Wha Pharm., Ind. Co. Ltd., Anyang 31041, Korea. dongrack.choi@dong-wha.co.kr.
authors.forename: Dong-Rack
authors.initials: DR
authors.lastname: Choi
authors.affiliation: School of Life Science, Handong Global University, 558 Handong-ro, Buk-gu, Pohang 37554, Korea. jhkwak@handong.edu.
authors.forename: Jin-Hwan
authors.initials: JH
authors.lastname: Kwak
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D024841:Fluoroquinolones / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D008813:Mice, Inbred ICR; D008826:Microbial Sensitivity Tests; D011008:Pneumococcal Infections / Q000188:drug therapy*; D012141:Respiratory Tract Infections / Q000188:drug therapy* / Q000382:microbiology; D013296:Streptococcus pneumoniae / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; C480202:zabofloxacin
keywords: Streptococcus pneumoniae; in vivo; minimum inhibitory concentration; zabofloxacin