title: Effect of magnesium sulfate on morphine activity retention to control pain after herniorrhaphy.
abstract: OBJECTIVE
  This research was carried out to compare magnesium sulfate (MgSO4) with isotonic saline in terms of pain control after herniorrhaphy.
  
  
  METHODS
  A randomized double-blind study, in which the patients were blind to all. A total of 100 patients who were candidates of herniorrhaphy were randomized into two groups: experimental and control (50 patients in each). Anesthesia was induced with 20% of 4 cc of morphine. The experimental and control group received postoperative 20% of 2 cc MgSO4in 2 cc of isotonic saline and 4 cc of isotonic saline, respectively.
  
  
  RESULTS
  The administration of postoperative morphine in control group 0.79 ± 1.48 mg was significantly higher to the experimental group 0.17 ± 0.63 mg during the first 24 h (p = 0.01).
  
  
  CONCLUSIONS
  MgSO4increased the potency of morphine thereby reducing the amount of postoperative pain killer needed.
authors.affiliation: Department of Anesthesiology, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.
authors.forename: Sedigheh
authors.initials: S
authors.lastname: Nadri
authors.affiliation: Department of Surgery, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.
authors.forename: Hormoz
authors.initials: H
authors.lastname: Mahmoudvand
authors.affiliation: Department of Anesthesiology, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.
authors.forename: Sepideh
authors.initials: S
authors.lastname: Vahabi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000701:Analgesics, Opioid / Q000627:therapeutic use*; D004311:Double-Blind Method; D059685:Herniorrhaphy / Q000009:adverse effects*; D006801:Humans; D008278:Magnesium Sulfate / Q000627:therapeutic use*; D008875:Middle Aged; D009020:Morphine / Q000627:therapeutic use*; D010147:Pain Measurement; D010149:Postoperative Pain / Q000188:drug therapy* / Q000209:etiology; D055815:Young Adult
chemical_list: D000701:Analgesics, Opioid; D008278:Magnesium Sulfate; D009020:Morphine
keywords: herniorrhaphy; magnesium sulfate; morphine; pain