title: T7 Phage Display Library a Promising Strategy to Detect Tuberculosis Specific Biomarkers.
abstract: One-third of the world's population is infected with tuberculosis, only 10% will develop active disease and the remaining 90% is considered to have latent TB (LTB). While active TB is contagious and can be lethal, the LTB can evolve to active TB. The diagnosis of TB can be challenging, especially in the early stages, due to the variability in presentation and nonspecific signs and symptoms. Currently, we have limited tools available to diagnose active TB, predict treatment efficacy and cure of active tuberculosis, the reactivation of latent tuberculosis infection, and the induction of protective immune responses through vaccination. Therefore, the identification of robust and accurate tuberculosis-specific biomarkers is crucial for the successful eradication of TB. In this commentary, we summarized the available methods for diagnosis and differentiation of active TB from LTB and their limitations. Additionally, we present a novel peptide microarray platform as promising strategy to identify TB biomarkers.
authors.affiliation: Department of Internal Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Wayne State University School of Medicine and Detroit Medical Center, Detroit, MI.
authors.forename: Harvinder
authors.initials: H
authors.lastname: Talwar
authors.affiliation: Department of Internal Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Wayne State University School of Medicine and Detroit Medical Center, Detroit, MI.
authors.forename: Jaya
authors.initials: J
authors.lastname: Talreja
authors.affiliation: Department of Internal Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Wayne State University School of Medicine and Detroit Medical Center, Detroit, MI; Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, E. Canfield, Detroit, MI, USA.
authors.forename: Lobelia
authors.initials: L
authors.lastname: Samavati
keywords: Biomarker; Latent TB; Peptide microarray; Serum antibody; T7 phage display; TB; Tuberculosis