title: Thr105Ile (rs11558538) polymorphism in the histamine-1-methyl-transferase (HNMT) gene and risk for restless legs syndrome.
abstract: A recent meta-analysis suggests an association between the rs11558538 single nucleotide polymorphism in the histamine-N-methyl-transferase (HNMT) gene and the risk for Parkinson's disease. Based on the possible relationship between PD and restless legs syndrome (RLS), we tried to establish whether rs11558538 SNP is associated with the risk for RLS. We studied the genotype and allelic variant frequencies of HNMT rs11558538 SNP 205 RLS patients and 410 healthy controls using a TaqMan assay. The frequencies of the HNMT rs11558538 genotypes allelic variants were similar between RLS patients and controls, and were not influenced by gender, family history of RLS, or RLS severity. RLS patients carrying the genotype rs11558538TT had an earlier age at onset, but this finding was based on three subjects only. These results suggest a lack of major association between HNMT rs11558538 SNP and the risk for RLS.
authors.affiliation: Section of Neurology, Hospital Universitario del Sureste, C/Marroquina 14, 3º B, 28030, Arganda del Rey, Madrid, Spain. fjavier.jimenez@salud.madrid.org.|Department of Medicine-Neurology, Hospital "Príncipe de Asturias", Universidad de Alcalá, Alcalá de Henares, Madrid, Spain. fjavier.jimenez@salud.madrid.org.
authors.forename: Félix Javier
authors.initials: FJ
authors.lastname: Jiménez-Jiménez
authors.affiliation: Department of Pharmacology, Universidad de Extremadura, Cáceres, Spain.
authors.forename: Elena
authors.initials: E
authors.lastname: García-Martín
authors.affiliation: Section of Neurology, Hospital Universitario del Sureste, C/Marroquina 14, 3º B, 28030, Arganda del Rey, Madrid, Spain.|Department of Medicine-Neurology, Hospital "Príncipe de Asturias", Universidad de Alcalá, Alcalá de Henares, Madrid, Spain.
authors.forename: Hortensia
authors.initials: H
authors.lastname: Alonso-Navarro
authors.affiliation: Department of Pharmacology, University of Extremadura, Badajoz, Spain.
authors.forename: Carmen
authors.initials: C
authors.lastname: Martínez
authors.affiliation: Section of Neurology, Hospital Virgen del Puerto, Plasencia, Cáceres, Spain.
authors.forename: Martín
authors.initials: M
authors.lastname: Zurdo
authors.affiliation: Section of Neurology, Hospital La Mancha-Centro, Alcázar de San Juan, Ciudad Real, Spain.
authors.forename: Laura
authors.initials: L
authors.lastname: Turpín-Fenoll
authors.affiliation: Section of Neurology, Hospital La Mancha-Centro, Alcázar de San Juan, Ciudad Real, Spain.
authors.forename: Jorge
authors.initials: J
authors.lastname: Millán-Pascual
authors.affiliation: Unit of Neurology, Clínica Recoletas, Zamora, Spain.
authors.forename: Teresa
authors.initials: T
authors.lastname: Adeva-Bartolomé
authors.affiliation: Section of Neurology, Hospital Universitario de Burgos, Burgos, Spain.
authors.forename: Esther
authors.initials: E
authors.lastname: Cubo
authors.affiliation: Section of Neurology, Hospital Universitario del Sureste, C/Marroquina 14, 3º B, 28030, Arganda del Rey, Madrid, Spain.
authors.forename: Francisco
authors.initials: F
authors.lastname: Navacerrada
authors.affiliation: Department of Medicine-Neurology, Hospital "Príncipe de Asturias", Universidad de Alcalá, Alcalá de Henares, Madrid, Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: Rojo-Sebastián
authors.affiliation: Department of Medicine-Neurology, Hospital "Príncipe de Asturias", Universidad de Alcalá, Alcalá de Henares, Madrid, Spain.
authors.forename: Lluisa
authors.initials: L
authors.lastname: Rubio
authors.affiliation: CIBERNED, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Monforte de Lemos Street, Madrid, Spain.|Neurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research, Universidad de Navarra, Pamplona, Spain.|Department of Neurology, Clínica Universidad de Navarra, University of Navarra School of Medicine, Pamplona, Spain.
authors.forename: Sara
authors.initials: S
authors.lastname: Ortega-Cubero
authors.affiliation: CIBERNED, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Monforte de Lemos Street, Madrid, Spain.|Neurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research, Universidad de Navarra, Pamplona, Spain.|Department of Neurology, Clínica Universidad de Navarra, University of Navarra School of Medicine, Pamplona, Spain.|Department of Neurology, Hospital Universitari Mutua de Terrassa, Terrassa, Barcelona, Spain.
authors.forename: Pau
authors.initials: P
authors.lastname: Pastor
authors.affiliation: Section of Neurology, Hospital Universitario del Sureste, C/Marroquina 14, 3º B, 28030, Arganda del Rey, Madrid, Spain.
authors.forename: Marisol
authors.initials: M
authors.lastname: Calleja
authors.affiliation: Section of Neurology, Hospital Universitario del Sureste, C/Marroquina 14, 3º B, 28030, Arganda del Rey, Madrid, Spain.
authors.forename: José Francisco
authors.initials: JF
authors.lastname: Plaza-Nieto
authors.affiliation: Section of Neurology, Hospital Universitario del Sureste, C/Marroquina 14, 3º B, 28030, Arganda del Rey, Madrid, Spain.
authors.forename: Belén
authors.initials: B
authors.lastname: Pilo-de-la-Fuente
authors.affiliation: Section of Neurology, Hospital Universitario del Sureste, C/Marroquina 14, 3º B, 28030, Arganda del Rey, Madrid, Spain.
authors.forename: Margarita
authors.initials: M
authors.lastname: Arroyo-Solera
authors.affiliation: Department of Medicine-Neurology, Hospital "Príncipe de Asturias", Universidad de Alcalá, Alcalá de Henares, Madrid, Spain.
authors.forename: Esteban
authors.initials: E
authors.lastname: García-Albea
authors.affiliation: Department of Pharmacology, Universidad de Extremadura, Cáceres, Spain.
authors.forename: José A G
authors.initials: JA
authors.lastname: Agúndez
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D006637:Histamine N-Methyltransferase / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012148:Restless Legs Syndrome / Q000453:epidemiology / Q000235:genetics*; D012307:Risk Factors; D012720:Severity of Illness Index; D012737:Sex Factors; D055815:Young Adult
chemical_list: D006637:Histamine N-Methyltransferase
keywords: Genetics; HNMT gene; Polymorphisms; Restless legs syndrome; Risk factors