title: Impact of transient period of metabolic adaptation on perinatal asphyxia in neonates with intrauterine growth retardation.
abstract: BACKGROUND
  Temperature, glycemia and respiration make neonatal energy triangle (NET). In growth retardation (IUGR) neonates pathological metabolic adaptation exists in transient neonatal period.
  
  
  OBJECTIVE
  The of this study was to examine the occurrence of pathological NET and check its impact on perinatal asphyxia during the transient period in IUGR neonates.
  
  
  METHODS
  One hundred and fifty-nine neonates with IUGR were classified into - early preterm, late preterm and term neonates. By the presence of hypothermia, hypoglycemia and hypoxia in the first hour after birth neonates were classified into: group of pathological NET, group of unstable NET and group of stable NET. We analyzed distribution per body mass, gestational age, type of IUGR, gender and the frequency of perinatal asphyxia between the groups.
  
  
  RESULTS
  The late preterm neonates were the most frequent in the group of pathological NET. Perinatal asphyxia was diagnosed in 52 (32.7%) neonates, with highest frequency in the group of pathological NET. Univariate binary logistic regression analysis showed that pathological NET in neonates with IUGR is significant predictor for perinatal asphyxia occurrence (OR = 8.57; CI = 4.05-18.12; p < 0.001 R2= 0.27).
  
  
  CONCLUSIONS
  Poor metabolic adaptation in neonates with IUGR in the first hour after birth is significant risk factor for the perinatal asphyxia.
authors.affiliation: a Department of Neonatology , University Clinic for Gynecology and Obstetrics "Narodni Front" , Belgrade , Serbia.
authors.forename: Tanja
authors.initials: T
authors.lastname: Lazic Mitrovic
authors.affiliation: b Department of High-risk Pregnancies , University Clinic for Gynecology and Obstetrics "Narodni Front", School of Medicine, University of Belgrade , Belgrade , Serbia.
authors.forename: Zeljko
authors.initials: Z
authors.lastname: Mikovic
authors.affiliation: b Department of High-risk Pregnancies , University Clinic for Gynecology and Obstetrics "Narodni Front", School of Medicine, University of Belgrade , Belgrade , Serbia.
authors.forename: Vesna
authors.initials: V
authors.lastname: Mandic Markovic
authors.affiliation: c School of Medicine , University of Belgrade , Belgrade , Serbia.
authors.forename: Smiljana
authors.initials: S
authors.lastname: Mihailovic
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology*; D001238:Asphyxia Neonatorum / Q000150:complications* / Q000378:metabolism*; D004734:Energy Metabolism / Q000502:physiology*; D005260:Female; D005317:Fetal Growth Retardation / Q000378:metabolism*; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000378:metabolism; D008297:Male; D011247:Pregnancy; D012189:Retrospective Studies; D013997:Time Factors
keywords: Fetal growth retardation; neonatal energy triangle; perinatal asphyxia