title: Building confidence in quantitative systems pharmacology models: An engineer's guide to exploring the rationale in model design and development.
abstract: This tutorial promotes good practice for exploring the rationale of systems pharmacology models. A safety systems engineering inspired notation approach provides much needed rigor and transparency in development and application of models for therapeutic discovery and design of intervention strategies. Structured arguments over a model's development, underpinning biological knowledge, and analyses of model behaviors are constructed to determine the confidence that a model is fit for the purpose for which it will be applied.
authors.affiliation: Department of Electronics, The University of York, York, UK.|SimOmics Limited, York, UK.
authors.forename: J
authors.initials: J
authors.lastname: Timmis
authors.affiliation: Department of Electronics, The University of York, York, UK.
authors.forename: K
authors.initials: K
authors.lastname: Alden
authors.affiliation: SimOmics Limited, York, UK.
authors.forename: P
authors.initials: P
authors.lastname: Andrews
authors.affiliation: SimOmics Limited, York, UK.
authors.forename: E
authors.initials: E
authors.lastname: Clark
authors.affiliation: SimOmics Limited, York, UK.
authors.forename: A
authors.initials: A
authors.lastname: Nellis
authors.affiliation: Department of Electronics, The University of York, York, UK.|SimOmics Limited, York, UK.
authors.forename: B
authors.initials: B
authors.lastname: Naylor
authors.affiliation: Centre for Immunology and Infection, Hull York Medical School/University of York, York, UK.
authors.forename: M
authors.initials: M
authors.lastname: Coles
authors.affiliation: Centre for Immunology and Infection, Hull York Medical School/University of York, York, UK.
authors.forename: P
authors.initials: P
authors.lastname: Kaye
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000276:immunology / Q000627:therapeutic use; D001698:Biomedical Engineering / Q000379:methods* / Q000639:trends; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects / Q000276:immunology; D007898:Leishmaniasis, Visceral / Q000276:immunology / Q000628:therapy; D008954:Models, Biological; D049490:Systems Biology / Q000379:methods* / Q000639:trends
chemical_list: D000981:Antiprotozoal Agents