title: Trigeminal star-like platinum complexes induce cancer cell senescence through quadruplex-mediated telomere dysfunction.
abstract: Two trigeminal star-like platinum complexes were synthesized to induce the formation of human telomere G-quadruplex (hTel G4) with extremely high selectivity and affinity. The induced hTel G4 activates strong telomeric DNA damage response (TDDR), resulting in telomere dysfunction and cell senescence.
authors.affiliation: MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China. cesmzw@mail.sysu.edu.cn and School of Life Sciences, SunYat-Sen University, Guangzhou 510006, China.
authors.forename: Xiao-Hui
authors.initials: XH
authors.lastname: Zheng
authors.affiliation: MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China. cesmzw@mail.sysu.edu.cn.
authors.forename: Ge
authors.initials: G
authors.lastname: Mu
authors.affiliation: MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China. cesmzw@mail.sysu.edu.cn.
authors.forename: Yi-Fang
authors.initials: YF
authors.lastname: Zhong
authors.affiliation: School of Life Sciences, SunYat-Sen University, Guangzhou 510006, China.
authors.forename: Tian-Peng
authors.initials: TP
authors.lastname: Zhang
authors.affiliation: MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China. cesmzw@mail.sysu.edu.cn.
authors.forename: Qian
authors.initials: Q
authors.lastname: Cao
authors.affiliation: MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China. cesmzw@mail.sysu.edu.cn.
authors.forename: Liang-Nian
authors.initials: LN
authors.lastname: Ji
authors.affiliation: School of Life Sciences, SunYat-Sen University, Guangzhou 510006, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China. cesmzw@mail.sysu.edu.cn.
authors.forename: Zong-Wan
authors.initials: ZW
authors.lastname: Mao
mesh_terms: D045744:Cell Line, Tumor; D016922:Cellular Senescence / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D031541:Fluorescence Resonance Energy Transfer; D054856:G-Quadruplexes / Q000187:drug effects*; D006801:Humans; D015394:Molecular Structure; D009944:Organoplatinum Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D016615:Telomere / Q000187:drug effects* / Q000378:metabolism
chemical_list: D009944:Organoplatinum Compounds