title: Population structure of Haemonchus contortus from seven geographical regions in China, determined on the basis of microsatellite markers.
abstract: Studying genetic variation within and among Haemonchus contortus populations can inform some aspects of this parasite's population genetics and epidemiology. However, almost nothing is known about such variation in China.
  
  
  
  Adult males of H. contortus (n = 184) representing seven distinct populations in China were collected, and genetic variation within and among these populations was explored using eight distinct microsatellite markers.
  
  
  
  Genetic parameters, such as heterozygosity and inbreeding coefficient (FIS) indicated that all eight microsatellites were highly polymorphic. Various analyses (AMOVA, FST, phylogenetic, structure, mantel test and population dynamics) revealed high within-population variation, low population genetic differentiation and high gene flow for H. contortus in China.
  
  
  
  This study provides a first snapshot of the genetic substructuring of H. contortus populations in China using polymorphic markers, and might provide a starting point for assessing genetic changes over space and time during or following the implementation of particular treatment or control strategies, or changes as a consequence of environmental, management and climatic factors.
authors.affiliation: State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, Hubei Province, People's Republic of China.|State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Science, Lanzhou, 730046, Gansu Province, People's Republic of China.
authors.forename: Fangyuan
authors.initials: F
authors.lastname: Yin
authors.affiliation: State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, Hubei Province, People's Republic of China.|Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Victoria, 3010, Australia.
authors.forename: Robin B
authors.initials: RB
authors.lastname: Gasser
authors.affiliation: State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, Hubei Province, People's Republic of China.|State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Science, Lanzhou, 730046, Gansu Province, People's Republic of China.
authors.forename: Facai
authors.initials: F
authors.lastname: Li
authors.affiliation: College of Animal Sciences and Veterinary Medicine, Liaoling Medical College, Jingzhou, 121000, Liaoling Province, People's Republic of China.
authors.forename: Min
authors.initials: M
authors.lastname: Bao
authors.affiliation: Department of Veterinary Medicine, College of Animal Science and Technology, Guangxi University, Nanning, 530004, Guangxi Zhuang Nationality Autonomous Region, People's Republic of China.
authors.forename: Weiyi
authors.initials: W
authors.lastname: Huang
authors.affiliation: College of Animal Science and Technology, Yunnan Agricultural University, Kunming, 650201, Yunnan Province, People's Republic of China.
authors.forename: Fengcai
authors.initials: F
authors.lastname: Zou
authors.affiliation: College of Veterinary Medicine, Northwest A&F University, Yangling, 712100, Shaanxi Province, People's Republic of China.
authors.forename: Guanghui
authors.initials: G
authors.lastname: Zhao
authors.affiliation: College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing, 163319, Heilongjiang Province, People's Republic of China.
authors.forename: Chunren
authors.initials: C
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, Hubei Province, People's Republic of China.
authors.forename: Xin
authors.initials: X
authors.lastname: Yang
authors.affiliation: State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, Hubei Province, People's Republic of China.
authors.forename: Yanqin
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, Hubei Province, People's Republic of China.
authors.forename: Junlong
authors.initials: J
authors.lastname: Zhao
authors.affiliation: State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, Hubei Province, People's Republic of China.
authors.forename: Rui
authors.initials: R
authors.lastname: Fang
authors.affiliation: State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, Hubei Province, People's Republic of China. mhu@mail.hzau.edu.cn.
authors.forename: Min
authors.initials: M
authors.lastname: Hu
mesh_terms: D000818:Animals; D002681:China; D005260:Female; D051456:Gene Flow; D014644:Genetic Variation; D006188:Haemonchiasis / Q000469:parasitology*; D006189:Haemonchus / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats; D010802:Phylogeny
keywords: China; Genetic diversity; Haemonchus contortus; Microsatellites