title: Adalimumab Induced or Provoked MS in Patient with Autoimmune Uveitis: A Case Report and Review of the Literature.
abstract: Anti-tumor necrosis factorα(anti-TNF-α) agents have been widely used in the field of autoimmune diseases and have proved decisive efficacy and relative safety. Data concerning their adverse effects has been lately describing central nervous system (CNS) demyelination process at escalating basis.Case Presentation. A 23-year-old male with autoimmune uveitis and a family history of multiple sclerosis (MS) developed two neurological attacks, after Adalimumab infusion, simultaneously with several cerebral lesions on magnetic resonance imaging (MRI). Hence the diagnosis of Adalimumab induced MS was suspected.Conclusion. This case is reported to tell physicians to be cautious when using anti-TNF-αin patients with family history of MS and to reconsider the risk of MS in patients with autoimmune diseases.
authors.affiliation: Division of Neurology, Department of Internal Medicine, Aleppo University Hospital, Aleppo, Syria.
authors.forename: Rana
authors.identifier: 0000-0002-1737-9577
authors.initials: R
authors.lastname: Alnasser Alsukhni
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Aleppo University Hospital, Aleppo, Syria.
authors.forename: Ziena
authors.initials: Z
authors.lastname: Jriekh
authors.affiliation: Division of Neurology, Department of Internal Medicine, Aleppo University Hospital, Aleppo, Syria.
authors.forename: Yasmin
authors.initials: Y
authors.lastname: Aboras