title: Anti-cancerous triterpenoid saponins fromLecaniodiscus cupanioides.
abstract: From the ethanol extract of the stem ofLecaniodiscus cupanioidesPlanch, two known compounds1and2were isolated and identified as triterpenoid saponins 3-O-[α-L-arabinofuranosyl- (1→3)-α-L-rhamnopyranosyl- (1→2)-α-L-arabinopyranosyl-]-hederagenin and 3-O- [α-L-arabinopyranosyl- (1→3)-α-L-rhamnopyranosyl (1→2)-α-L-arabinopyranosyl-]-hederagenin. The structures were established by physicochemical and spectroscopic investigations (MS and NMR) as well as comparison of literature data. The compound1exhibited anticancer activity against human colon carcinoma H-116, human lung carcinoma A-549 and human lung carcinoma HT-29 cell lines with IC505.0, 2.5 and 2.5μg/ml respectively and compound2exhibited similar activities with IC505.0, 5.0 and 2.5μg/ml respectively. This suggests that the isolated triterpenoid saponins may be considered as potential anticancer leads for further studies.
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, University of Lagos, PMB 12003, Lagos, Nigeria.
authors.forename: S A
authors.initials: SA
authors.lastname: Adesegun
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Lagos, PMB 12003, Lagos, Nigeria.
authors.forename: H A B
authors.initials: HA
authors.lastname: Coker
authors.affiliation: Department of Pharmacognosy and National Center for Natural Products Research, School of Pharmacy, University of Mississippi, MS 38677 USA.
authors.forename: M T
authors.initials: MT
authors.lastname: Hamann
keywords: Anticancer; Cell lines; Lecaniodiscus cupanioides; Triperpenoid saponins