title: Recent advances onCandida albicansbiology and virulence.
abstract: Candida albicansis an important human fungal pathogen, in terms of both its clinical significance and its use as an experimental model for scientific investigation. Although this opportunistic pathogen is a natural component of the human flora, it can cause life-threatening infections in immunosuppressed patients. There are currently a limited number of antifungal molecules and drug targets, and increasing resistance to the front-line therapeutics, demonstrating a clear need for new antifungal drugs. Understanding the biology of this pathogen is an important prerequisite for identifying new drug targets for antifungal therapeutics. In this review, we highlight some recent developments that help us to understand how virulence traits are regulated at the molecular level, in addition to technical advances that improve the ability of genome editing inC. albicans.
authors.affiliation: Infectious Diseases Research Centre-CRI, CHU de Québec Research Center (CHUQ), Université Laval, Quebec City, Quebec, Canada; Department of Microbiology, Infectious Disease and Immunology, Faculty of Medicine, Université Laval, Quebec City, Quebec, Canada.
authors.forename: Adnane
authors.initials: A
authors.lastname: Sellam
authors.affiliation: Department of Biology, Concordia University, Montreal, Quebec, Canada.
authors.forename: Malcolm
authors.initials: M
authors.lastname: Whiteway
keywords: C. albicans; Candida albicans; antifungal drugs; genome editing; virulence