title: An Unexpected Chink in the Transcriptional Armor of Plasmacytoid Dendritic Neoplasms.
abstract: In this issue of Cancer Cell, Ceribelli et al. use functional genomic and chemical screening to reveal the existence of a TCF4/BRD4-dependent oncogenic regulatory network in blastic plasmacytoid dendritic cell neoplasm (BPDCN) and demonstrate that BPDCN cells are highly sensitive to therapeutic targeting of this novel dependency.
authors.affiliation: Human Oncology and Pathogenesis Program, Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 20, New York, NY 10065, USA.
authors.forename: Maria
authors.initials: M
authors.lastname: Kleppe
authors.affiliation: Human Oncology and Pathogenesis Program, Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 20, New York, NY 10065, USA. Electronic address: leviner@mskcc.org.
authors.forename: Ross L
authors.initials: RL
authors.lastname: Levine
mesh_terms: D003713:Dendritic Cells; D019337:Hematologic Neoplasms / Q000188:drug therapy*; D006801:Humans; D009196:Myeloproliferative Disorders; D012878:Skin Neoplasms