title: Preparation of DRV Liposomes.
abstract: Dried reconstituted vesicles (DRV) are liposomes that are formulated under mild conditions and have the capability to entrap substantially high amounts of hydrophilic solutes (compared to other types of liposomes). These characteristics make this liposome type ideal for entrapment of labile substances, as peptide, protein, or DNA vaccines, or in general biopharmaceuticals and sensitive drugs. In this chapter, all possible types of DRV liposomes (with respect to the encapsulated molecule characteristics and/or their applications in therapeutics) are introduced, and preparation methodologies (for each type) are described in detail.
authors.affiliation: Laboratory of Pharmaceutical Technology, Department of Pharmacy, University of Patras, 26510, Rio, Patras, Greece. santimis@upatras.gr.|FORTH/ICE-HT, 26510, Rio, Patras, Greece. santimis@upatras.gr.
authors.forename: Sophia G
authors.initials: SG
authors.lastname: Antimisiaris
mesh_terms: D001419:Bacteria / Q000737:chemistry; D001671:Biochemistry / Q000379:methods*; D003890:Desiccation; D057927:Hydrophobic and Hydrophilic Interactions; D008081:Liposomes / Q000737:chemistry*; D019444:Vaccines, DNA / Q000378:metabolism; D014780:Viruses / Q000737:chemistry
chemical_list: D008081:Liposomes; D019444:Vaccines, DNA
keywords: Bacteria; Biopharmaceuticals; Cyclodextrin; DNA; DRV; Encapsulation efficiency; Hydrophilic drug; Particulate; Peptide; Protein; Vaccine