title: Comparison of neutrophil-lymphocyte ratio (NLR) in Parkinson's disease subtypes.
abstract: It has been hypothesized that chronic inflammation may play an important role in the development and progression of the neurodegeneration of Idiopathic Parkinson's disease (IPD). Neutrophil-lymphocyte ratio (NLR) is a marker that indicates the peripheral inflammation. There is only one study regarding NLR and IPD. In this study, we assessed to investigate NLR in patients with IPD, comparing the results with controls and to determine whether there is a difference in NLR levels in subgroups of IPD (akinetic-rigid and tremor-dominant) differ in their levels of NLR. Medical records of 200 IPD patients and 60 controls reviewed retrospectively. Forty-six IPD patients met the inclusion criteria. NLR was calculated by dividing neutrophil count to lymphocyte count. Thirteen akinetic-rigid (AR-IPD) and thirty-three tremor-dominant (TD-IPD) patients' and controls results were compared. There was not a statistically difference between the NLR levels of IPD patients, controls, and AR-IPD and TD-IPD patients. This result suggests that cerebral inflammation is in the forefront in the development of neurodegeneration in IPD, and that more evidence is needed for the role of peripheral inflammation in the development progression of disease.
authors.affiliation: Department of Neurology, Ankara Training and Research Hospital, Ankara, Turkey. ceykubi@yahoo.com.
authors.forename: Ceyla
authors.identifier: http://orcid.org/0000-0002-3810-2526
authors.initials: C
authors.lastname: Ataç Uçar
authors.affiliation: Department of Neurology, Ankara Training and Research Hospital, Ankara, Turkey.
authors.forename: Burcu
authors.initials: B
authors.lastname: Gökçe Çokal
authors.affiliation: Department of Neurology, Ankara Training and Research Hospital, Ankara, Turkey.
authors.forename: Hanzade Aybüke
authors.initials: HA
authors.lastname: Ünal Artık
authors.affiliation: Department of Neurology, Bozok University Medical School, Yozgat, Turkey.
authors.forename: Levent Ertuğrul
authors.initials: LE
authors.lastname: İnan
authors.affiliation: Department of Neurology, Ankara Training and Research Hospital, Ankara, Turkey.
authors.forename: Tahir Kurtuluş
authors.initials: TK
authors.lastname: Yoldaş
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood*; D007958:Leukocyte Count; D008214:Lymphocytes; D008297:Male; D008875:Middle Aged; D009504:Neutrophils; D010300:Parkinson Disease / Q000097:blood* / Q000145:classification; D012189:Retrospective Studies
chemical_list: D015415:Biomarkers
keywords: Idiopathic Parkinson’s disease; Inflammation; Neurodegeneration; Parkinson’s disease subtypes