title: Outcome of Patients With Cardiac Sarcoidosis Who Received Cardiac Resynchronization Therapy: Comparison With Dilated Cardiomyopathy Patients.
abstract: Cardiac resynchronization therapy (CRT) has been shown to be effective for patients with chronic heart failure; however, the efficacy of CRT in patients with cardiac sarcoidosis (CS) has not been established.
  
  
  
  We compared the outcomes of patients with CS who received CRT to patients with dilated cardiomyopathy (DCM). The incidence of major adverse cerebral and cardiovascular events (MACCE) in 11 consecutive CS patients (8 females; mean age, 66 ± 8.0 years) who received CRT were compared with 29 DCM patients (9 females; mean age, 70 ± 8.9 years).
  
  
  
  Females and patients with previous right ventricular pacing were largely included in the comparison of CS and DCM patients (P < 0.05 and P < 0.0001, respectively). During the mean follow-up period (465 ± 383 days for CS and 729 ± 393 days for DCM), MACCE were evident in 9 patients (23%); specifically, 5 CS and 4 DCM patients developed MACCE (45% vs. 14%, P < 0.05), respectively. Kaplan-Meier survival analysis demonstrated that CS patients had a higher prevalence of MACCE than DCM patients (log rank = 6.306, P = 0.0120; and Wilcoxon = 7.1333, P = 0.0076). Based on univariate analysis, the etiology of CS was associated with MACCE.
  
  
  
  Our results suggest that the long-term outcome of CRT in patients with CS was very poor compared with DCM patients. Thus, caution should be exercised regarding the indication of CRT in patients with CS.
authors.affiliation: Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University, Yufu-city, Oita, Japan.
authors.forename: Kunio
authors.initials: K
authors.lastname: Yufu
authors.affiliation: Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University, Yufu-city, Oita, Japan.
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Kondo
authors.affiliation: Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University, Yufu-city, Oita, Japan.
authors.forename: Tetsuji
authors.initials: T
authors.lastname: Shinohara
authors.affiliation: Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University, Yufu-city, Oita, Japan.
authors.forename: Kyoko
authors.initials: K
authors.lastname: Kawano
authors.affiliation: Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University, Yufu-city, Oita, Japan.
authors.forename: Yumi
authors.initials: Y
authors.lastname: Ishii
authors.affiliation: Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University, Yufu-city, Oita, Japan.
authors.forename: Miho
authors.initials: M
authors.lastname: Miyoshi
authors.affiliation: Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University, Yufu-city, Oita, Japan.
authors.forename: Takaaki
authors.initials: T
authors.lastname: Imamura
authors.affiliation: Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University, Yufu-city, Oita, Japan.
authors.forename: Shotaro
authors.initials: S
authors.lastname: Saito
authors.affiliation: Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University, Yufu-city, Oita, Japan.
authors.forename: Norihiro
authors.initials: N
authors.lastname: Okada
authors.affiliation: Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University, Yufu-city, Oita, Japan.
authors.forename: Hidefumi
authors.initials: H
authors.lastname: Akioka
authors.affiliation: Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University, Yufu-city, Oita, Japan.
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Teshima
authors.affiliation: Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University, Yufu-city, Oita, Japan.
authors.forename: Mikiko
authors.initials: M
authors.lastname: Nakagawa
authors.affiliation: Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University, Yufu-city, Oita, Japan.
authors.forename: Naohiko
authors.initials: N
authors.lastname: Takahashi
mesh_terms: D000368:Aged; D058406:Cardiac Resynchronization Therapy / Q000009:adverse effects; D009202:Cardiomyopathies / Q000175:diagnosis / Q000401:mortality / Q000503:physiopathology / Q000628:therapy*; D002311:Cardiomyopathy, Dilated / Q000175:diagnosis / Q000401:mortality / Q000503:physiopathology / Q000628:therapy*; D002561:Cerebrovascular Disorders / Q000209:etiology; D018572:Disease-Free Survival; D005260:Female; D006333:Heart Failure / Q000209:etiology; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D018579:Patient Selection; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D012507:Sarcoidosis / Q000175:diagnosis / Q000401:mortality / Q000503:physiopathology / Q000628:therapy*; D013997:Time Factors; D016896:Treatment Outcome
keywords: cardiac resynchronization therapy; cardiac sarcoidosis; dilated cardiomyopathy; long-term outcome