title: MitraClip Therapy for Mitral Regurgitation: Secondary Mitral Regurgitation.
abstract: Therapy for mitral regurgitation (MR) has been synonymous with mitral valve surgery. Operative approaches for degenerative MR repair have been associated with excellent results, with durable long term outcomes. Surgery for functional MR has been less successful. MitraClip has shown promise for functional MR, especiall in patinets who are high risk for surgery. The aggregate of nonrandomized global experience with MitraClip in functional MR has been consistent in showing improvements in symptoms and left ventricular remodeling. It remains to be seen how MitraClip therapy will compare with best medical therapy. The COAPT trial will clarify this question.
authors.affiliation: NorthShore University HealthSystem, Evanston, IL, USA. Electronic address: tfeldman@tfeldman.org.
authors.forename: Ted
authors.initials: T
authors.lastname: Feldman
authors.affiliation: NorthShore University HealthSystem, Evanston, IL, USA.
authors.forename: Arjun
authors.initials: A
authors.lastname: Mehta
authors.affiliation: NorthShore University HealthSystem, Evanston, IL, USA.
authors.forename: Mayra
authors.initials: M
authors.lastname: Guerrero
authors.affiliation: NorthShore University HealthSystem, Evanston, IL, USA.
authors.forename: Justin P
authors.initials: JP
authors.lastname: Levisay
authors.affiliation: NorthShore University HealthSystem, Evanston, IL, USA.
authors.forename: Michael H
authors.initials: MH
authors.lastname: Salinger
mesh_terms: D006348:Cardiac Surgical Procedures; D019918:Heart Valve Prosthesis Implantation; D006801:Humans; D008944:Mitral Valve Insufficiency / Q000601:surgery*; D016896:Treatment Outcome; D020257:Ventricular Remodeling
keywords: COAPT; Functional mitral regurgitation; MitraClip; Mitral regurgitation