title: Diagnosing necrotic meningioma: a distinctive imaging pattern in diffusion MRI and MR spectroscopy.
abstract: The differential diagnosis of necrotic meningiomas includes brain abscess and malignant neoplasms. We report and discuss hereby the work-up of two patients diagnosed with necrotic meningioma using diffusion-weighted imaging, magnetic resonance spectroscopy, resective surgery, and histopathology. The purpose of the present article is to add to the scant literature on the use of advanced imaging modalities in the routine investigation of brain lesions and their utility in arriving at the final diagnosis.
authors.affiliation: 1 Department of Radiology, Soroka Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
authors.forename: Gal
authors.initials: G
authors.lastname: Ben-Arie
authors.affiliation: 2 Department of Physiology and Cell Biology, Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
authors.forename: Yonatan
authors.initials: Y
authors.lastname: Serlin
authors.affiliation: 3 Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Germany.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Ivens
authors.affiliation: 4 Department of Neurosurgery, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
authors.forename: Mony
authors.initials: M
authors.lastname: Benifla
authors.affiliation: 5 Department of Pathology, Tel Aviv Medical Center, affiliated with the Sackler School of Medicine, Israel.
authors.forename: Emanuela
authors.initials: E
authors.lastname: Cagnano
authors.affiliation: 6 Department of Neurosurgery, Soroka Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
authors.forename: Israel
authors.initials: I
authors.lastname: Melamed
authors.affiliation: 6 Department of Neurosurgery, Soroka Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
authors.forename: Vladimir
authors.initials: V
authors.lastname: Merkin
authors.affiliation: 1 Department of Radiology, Soroka Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
authors.forename: Ilan
authors.initials: I
authors.lastname: Shelef
mesh_terms: D002794:Choline / Q000378:metabolism; D003937:Diagnosis, Differential; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D018698:Glutamic Acid / Q000378:metabolism; D005973:Glutamine / Q000378:metabolism; D006801:Humans; D019344:Lactic Acid / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008577:Meningeal Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism*; D008579:Meningioma / Q000000981:diagnostic imaging* / Q000378:metabolism*; D008875:Middle Aged; D009336:Necrosis / Q000000981:diagnostic imaging; D014316:Tritium / Q000378:metabolism
chemical_list: D005973:Glutamine; D014316:Tritium; D019344:Lactic Acid; D018698:Glutamic Acid; D002794:Choline
keywords: Diffusion-weighted imaging; magnetic resonance spectroscopy; necrotic meningioma