title: Epidemiology for primary brain tumors: a nationwide population-based study.
abstract: Primary central nervous system tumors (PCNST) are rare tumors responsible for high mortality and morbidity. Their epidemiology is poorly known, and clinical data are scarcely analyzed at a national level. In this study, we aimed at providing descriptive epidemiological data and incidence rates for all histological subtypes of PCNST according to the WHO classification. We conducted a nationwide population-based study of all newly diagnosed and histologically confirmed PCNST in France, between 2006 and 2011. A total of 57,816 patients were included: male 46.4%, median age at diagnosis 56 years old (range 0-99). For all newly diagnosed PCNST with histological confirmation the crude incidence rate was 15.5/105per 100,000 person-years. To enable international comparisons, standardized rates were calculated: 14.1/105(population of reference: USA), 14.5/105(population of reference: Europe), and 12.0/105(population of reference: world). 23.4% of samples were cryopreserved. Resection was performed in 79.1% of cases. Results are detailed (incidence rate, sex ratio, median age at diagnosis, number of cryopreserved samples, and type of surgery) for each of the 143 histological subtypes of PCNST, including all rare tumors. For example, incidence rates (population of reference: USA) were 0.018/105for anaplastic gangliogliomas, 0.054/105for malignant meningiomas, and 0.036/105for hemangiopericytomas. Our study is the first to describe incidence rates and epidemiological data for all histological subtypes of PCNST, including rare tumors, at a national level. Its methodology ensures the exhaustiveness of the data collection for histologically-proven cases. Histological population-based studies have many perspectives in the field of clinical epidemiology and research.
authors.affiliation: Department of Medical Oncology, Institut Régional du Cancer de Montpellier (ICM)-Val d'Aurelle, 208 rue des Apothicaires, 34298, Montpellier, France. amelie.darlix@icm.unicancer.fr.|INSERM U1051, 80 avenue Augustin Fliche, 34091, Montpellier, France. amelie.darlix@icm.unicancer.fr.
authors.forename: Amélie
authors.identifier: 0000-0003-1384-1709
authors.initials: A
authors.lastname: Darlix
authors.affiliation: Department of Epidemiology, French brain tumor database, GNOLR, Registre des Tumeurs de l'Hérault, Institut Régional du Cancer de Montpellier (ICM)-Val d'Aurelle, 208 rue des Apothicaires, 34298, Montpellier, France.|Department of Neurosurgery, Gui de Chauliac Hospital, 80 avenue Augustin Fliche, 34090, Montpellier, France.
authors.forename: Sonia
authors.initials: S
authors.lastname: Zouaoui
authors.affiliation: Department of Pathology, Gui de Chauliac Hospital, 80 avenue Augustin Fliche, 34090, Montpellier, France.
authors.forename: Valérie
authors.initials: V
authors.lastname: Rigau
authors.affiliation: Department of Epidemiology, French brain tumor database, GNOLR, Registre des Tumeurs de l'Hérault, Institut Régional du Cancer de Montpellier (ICM)-Val d'Aurelle, 208 rue des Apothicaires, 34298, Montpellier, France.
authors.forename: Faiza
authors.initials: F
authors.lastname: Bessaoud
authors.affiliation: Department of Neuropathology and INSERM U911, Timone Hospital, Université de la Méditerranée, 40 rue Ste Baume, 13010, Marseille, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Figarella-Branger
authors.affiliation: Department of Epidemiology, French brain tumor database, GNOLR, Registre des Tumeurs de l'Hérault, Institut Régional du Cancer de Montpellier (ICM)-Val d'Aurelle, 208 rue des Apothicaires, 34298, Montpellier, France.
authors.forename: Hélène
authors.initials: H
authors.lastname: Mathieu-Daudé
authors.affiliation: Department of Epidemiology, French brain tumor database, GNOLR, Registre des Tumeurs de l'Hérault, Institut Régional du Cancer de Montpellier (ICM)-Val d'Aurelle, 208 rue des Apothicaires, 34298, Montpellier, France.
authors.forename: Brigitte
authors.initials: B
authors.lastname: Trétarre
authors.affiliation: Department of Epidemiology, French brain tumor database, GNOLR, Registre des Tumeurs de l'Hérault, Institut Régional du Cancer de Montpellier (ICM)-Val d'Aurelle, 208 rue des Apothicaires, 34298, Montpellier, France.
authors.forename: Fabienne
authors.initials: F
authors.lastname: Bauchet
authors.affiliation: INSERM U1051, 80 avenue Augustin Fliche, 34091, Montpellier, France.|Department of Neurosurgery, Gui de Chauliac Hospital, 80 avenue Augustin Fliche, 34090, Montpellier, France.
authors.forename: Hugues
authors.initials: H
authors.lastname: Duffau
authors.affiliation: Neuro-oncology Unit, University Hospital, 29 avenue du Maréchal de Lattre de Tassigny, Nancy, France.
authors.forename: Luc
authors.initials: L
authors.lastname: Taillandier
authors.affiliation: INSERM U1051, 80 avenue Augustin Fliche, 34091, Montpellier, France.|Department of Neurosurgery, Gui de Chauliac Hospital, 80 avenue Augustin Fliche, 34090, Montpellier, France.
authors.forename: Luc
authors.initials: L
authors.lastname: Bauchet
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001932:Brain Neoplasms / Q000453:epidemiology*; D002648:Child; D002675:Child, Preschool; D016208:Databases, Factual; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D055815:Young Adult
keywords: Brain tumor; Database; Epidemiology; Incidence; Neuro-oncology; Neuropathology