title: Making the diagnosis, the tools, and risk stratification: More than just BCR-ABL.
abstract: The implementation of cytogenetic and molecular techniques into standard clinical practice has improved our ability to more accurately diagnose and monitor CML. Routine peripheral blood BCR-ABL transcript testing can help monitor response, predict outcome, and detect early resistance or poor adherence to TKI therapy. The widely-used Sokal, Hasford and EUTOS clinical risk stratification scores were developed in patients receiving chemotherapy, interferon and imatinib, respectively; their predictive ability in patients receiving next-generation tyrosine kinase inhibitors (TKIs) remains to be established. Newer more sensitive molecular techniques are being developed that may aid in the expanding emphasis on discontinuing therapy in patients with a deep and consistent molecular response.
authors.affiliation: Clinical Research Division, Fred Hutchinson Cancer Research Center, United States. Electronic address: degan@fredhutch.org.
authors.forename: Daniel
authors.initials: D
authors.lastname: Egan
authors.affiliation: Clinical Research Division, Fred Hutchinson Cancer Research Center, United States. Electronic address: jradich@fredhutch.org.
authors.forename: Jerald
authors.initials: J
authors.lastname: Radich
mesh_terms: D002986:Clinical Trials as Topic; D016044:Fusion Proteins, bcr-abl / Q000235:genetics / Q000378:metabolism; D006801:Humans; D000068877:Imatinib Mesylate / Q000627:therapeutic use*; D007372:Interferons / Q000627:therapeutic use*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000175:diagnosis / Q000188:drug therapy / Q000201:enzymology / Q000235:genetics; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use*; D018570:Risk Assessment
chemical_list: D047428:Protein Kinase Inhibitors; D000068877:Imatinib Mesylate; D007372:Interferons; D016044:Fusion Proteins, bcr-abl
keywords: BCR-ABL tyrosine kinase; Chronic; Cytogenetic techniques; Diagnoses and examinations; Fluorescent in situ hybridization; Leukemia; Myeloid; PCR; Philadelphia chromosome