title: Alcohol use disorder and its impact on chronic hepatitis C virus and human immunodeficiency virus infections.
abstract: Alcohol use disorder (AUD) and hepatitis C virus (HCV) infection frequently co-occur. AUD is associated with greater exposure to HCV infection, increased HCV infection persistence, and more extensive liver damage due to interactions between AUD and HCV on immune responses, cytotoxicity, and oxidative stress. Although AUD and HCV infection are associated with increased morbidity and mortality, HCV antiviral therapy is less commonly prescribed in individuals with both conditions. AUD is also common in human immunodeficiency virus (HIV) infection, which negatively impacts proper HIV care and adherence to antiretroviral therapy, and liver disease. In addition, AUD and HCV infection are also frequent within a proportion of patients with HIV infection, which negatively impacts liver disease. This review summarizes the current knowledge regarding pathological interactions of AUD with hepatitis C infection, HIV infection, and HCV/HIV co-infection, as well as relating to AUD treatment interventions in these individuals.
authors.affiliation: Daniel Fuster, Arantza Sanvisens, Jordi Tor, Robert Muga, Department of Internal Medicine, Addiction Unit, Hospital Universitari Germans Trias i Pujol, 08916 Badalona, Spain.
authors.forename: Daniel
authors.initials: D
authors.lastname: Fuster
authors.affiliation: Daniel Fuster, Arantza Sanvisens, Jordi Tor, Robert Muga, Department of Internal Medicine, Addiction Unit, Hospital Universitari Germans Trias i Pujol, 08916 Badalona, Spain.
authors.forename: Arantza
authors.initials: A
authors.lastname: Sanvisens
authors.affiliation: Daniel Fuster, Arantza Sanvisens, Jordi Tor, Robert Muga, Department of Internal Medicine, Addiction Unit, Hospital Universitari Germans Trias i Pujol, 08916 Badalona, Spain.
authors.forename: Ferran
authors.initials: F
authors.lastname: Bolao
authors.affiliation: Daniel Fuster, Arantza Sanvisens, Jordi Tor, Robert Muga, Department of Internal Medicine, Addiction Unit, Hospital Universitari Germans Trias i Pujol, 08916 Badalona, Spain.
authors.forename: Inmaculada
authors.initials: I
authors.lastname: Rivas
authors.affiliation: Daniel Fuster, Arantza Sanvisens, Jordi Tor, Robert Muga, Department of Internal Medicine, Addiction Unit, Hospital Universitari Germans Trias i Pujol, 08916 Badalona, Spain.
authors.forename: Jordi
authors.initials: J
authors.lastname: Tor
authors.affiliation: Daniel Fuster, Arantza Sanvisens, Jordi Tor, Robert Muga, Department of Internal Medicine, Addiction Unit, Hospital Universitari Germans Trias i Pujol, 08916 Badalona, Spain.
authors.forename: Robert
authors.initials: R
authors.lastname: Muga
keywords: Alcohol; Hepatitis C virus; Hepatitis C virus/human immunodeficiency virus co-infection; Human immunodeficiency virus; Liver