title: Noncoding RNAs as novel biomarkers in pancreatic cancer: what do we know?
abstract: Pancreatic cancer is an aggressive cancer of the digestive system, which is becoming a serious health problem worldwide. Overall survival for patients with pancreatic cancer is poor, mainly due to a lack of biomarkers to enable early diagnosis and a lack of prognostic markers that can inform decision-making, facilitating personalized treatment and an optimal clinical outcome. ncRNAs play an important role in pancreatic carcinogenesis. Here we review the literature on the role of ncRNAs as biomarkers in pancreatic cancer. We focus on the significance of ncRNAs as markers for early diagnosis, as prognostic biomarkers able to inform clinical management and as targets for novel therapeutics for patients with pancreatic cancer.
authors.affiliation: Division of Cancer Therapeutics, The Institute of Cancer Research, 15 Cotswold Rd, Sutton, SM2 5NG, UK.
authors.forename: Maria C
authors.initials: MC
authors.lastname: Previdi
authors.affiliation: Division of Cancer Therapeutics, The Institute of Cancer Research, 15 Cotswold Rd, Sutton, SM2 5NG, UK.
authors.forename: Pietro
authors.initials: P
authors.lastname: Carotenuto
authors.affiliation: Division of Cancer Therapeutics, The Institute of Cancer Research, 15 Cotswold Rd, Sutton, SM2 5NG, UK.
authors.forename: Domenico
authors.initials: D
authors.lastname: Zito
authors.affiliation: Division of Cancer Therapeutics, The Institute of Cancer Research, 15 Cotswold Rd, Sutton, SM2 5NG, UK.
authors.forename: Rosantony
authors.initials: R
authors.lastname: Pandolfo
authors.affiliation: Division of Cancer Therapeutics, The Institute of Cancer Research, 15 Cotswold Rd, Sutton, SM2 5NG, UK.|The Royal Marsden NHS Trust London & Surrey, Downs Rd, Sutton, SM2 5NG, UK.
authors.forename: Chiara
authors.initials: C
authors.lastname: Braconi
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics; D014408:Biomarkers, Tumor; D015972:Gene Expression Regulation, Neoplastic; D015316:Genetic Therapy; D006801:Humans; D035683:MicroRNAs / Q000235:genetics; D010190:Pancreatic Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000401:mortality / Q000628:therapy; D011379:Prognosis; D062085:RNA, Long Noncoding; D012333:RNA, Messenger; D022661:RNA, Untranslated
chemical_list: D014408:Biomarkers, Tumor; D035683:MicroRNAs; D062085:RNA, Long Noncoding; D012333:RNA, Messenger; D022661:RNA, Untranslated
keywords: biomarker; lncRNA; miRNA; ncRNA; pancreatic cancer