title: Mechanical Circulatory Support Devices for Pediatric Patients With Congenital Heart Disease.
abstract: The use of mechanical circulatory support (MCS) devices is a viable therapeutic treatment option for patients with congestive heart failure. Ventricular assist devices, cavopulmonary assist devices, and total artificial heart pumps continue to gain acceptance as viable treatment strategies for both adults and pediatric patients as bridge-to-transplant, bridge-to-recovery, and longer-term circulatory support alternatives. We present a review of the current and future MCS devices for patients having congenital heart disease (CHD) with biventricular or univentricular circulations. Several devices that are specifically designed for patients with complex CHD are in the development pipeline undergoing rigorous animal testing as readiness experiments in preparation for future clinical trials. These advances in the development of new blood pumps for patients with CHD will address a significant unmet clinical need, as well as generally improve innovation of the current state of the art in MCS technology.
authors.affiliation: BioCirc Research Laboratory, School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA.
authors.forename: Steven G
authors.initials: SG
authors.lastname: Chopski
authors.affiliation: Division of Pediatric Cardiology, Children's Hospital of Richmond and School of Medicine, Virginia Commonwealth University, Richmond, VA.
authors.forename: William B
authors.initials: WB
authors.lastname: Moskowitz
authors.affiliation: St. Christopher's Hospital for Children, Tenet Healthcare Corporation, Philadelphia, PA, USA.
authors.forename: Randy M
authors.initials: RM
authors.lastname: Stevens
authors.affiliation: BioCirc Research Laboratory, School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA.
authors.forename: Amy L
authors.initials: AL
authors.lastname: Throckmorton
mesh_terms: D000818:Animals; D001243:Assisted Circulation / Q000295:instrumentation / Q000379:methods; D002648:Child; D004867:Equipment Design; D015199:Extracorporeal Membrane Oxygenation / Q000295:instrumentation / Q000379:methods; D006330:Heart Defects, Congenital / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D006352:Heart Ventricles / Q000473:pathology / Q000601:surgery; D006354:Heart, Artificial; D006801:Humans; D010372:Pediatrics / Q000295:instrumentation / Q000379:methods; D016276:Ventricular Function
keywords: -Blood pump; -Congenital heart disease; -Pediatric circulatory support; -Ventricular assist device; Mechanical circulatory assistance