title: Effectiveness of an exercise programme on physical function in patients discharged from hospital following critical illness: a randomised controlled trial (the REVIVE trial).
abstract: To investigate the effectiveness of a 6-week exercise programme in patients discharged home following critical illness compared with standard care.
  
  
  
  Multicentre prospective phase II randomised controlled trial, with blinded outcome assessment after hospital discharge, following the 6-week intervention and at 6 months.
  
  
  
  60 patients (30 per group) aged ≥18 years, mechanically ventilated >96 hours, and not in other rehabilitation, that is, cardiac or pulmonary rehabilitation programmes. Participants in the intervention group completed an individually tailored (personalised) exercise programme.
  
  
  
  Primary outcome measure was SF-36 physical functioning following the intervention. Secondary outcomes included a range of performance-based and patient-reported measures.
  
  
  
  Improvements in the primary outcome did not differ significantly between groups (mean difference (95% CI) 3.0 (-2.2 to 8.2), p=0.26). The intervention group showed significant improvement compared with the control group (mean difference (95% CI)) in SF-36 role physical (6.6 (0.73 to 12.5), p=0.03); incremental shuttle walk test (83.1 m (8.3 to 157.9), p=0.03); functional limitations profile (-4.8 (-8.7 to -0.9), p=0.02); self-efficacy to exercise (2.2 (0.8 to 3.7), p=0.01) and readiness to exercise (1.3 (0.8 to 1.9), p<0.001). These improvements were not sustained at 6 months except readiness to exercise. Improvements in all other secondary outcome measures were not significant.
  
  
  
  There was no statistically significant difference in the primary outcome measure of self-reported physical function following this 6-week exercise programme. Secondary outcome results will help inform future studies.
  
  
  
  NCT01463579. (results), https://clinicaltrials.gov/.
authors.affiliation: Centre for Health and Rehabilitation Technologies, Ulster University, Newtownabbey, UK.
authors.forename: Kathryn
authors.initials: K
authors.lastname: McDowell
authors.affiliation: Centre for Health and Rehabilitation Technologies, Ulster University, Newtownabbey, UK.
authors.forename: Brenda
authors.initials: B
authors.lastname: O'Neill
authors.affiliation: Centre Experimental Medicine, School of Medicine, Dentistry & Biomedical Sciences, Queen's University Belfast, Northern Ireland, UK.
authors.forename: Bronagh
authors.initials: B
authors.lastname: Blackwood
authors.affiliation: Intensive Care Unit, Craigavon Area Hospital, Craigavon, UK.
authors.forename: Chris
authors.initials: C
authors.lastname: Clarke
authors.affiliation: Northern Ireland Clinical Trials Unit, Belfast, UK.
authors.forename: Evie
authors.initials: E
authors.lastname: Gardner
authors.affiliation: Intensive Care Unit, Antrim Area Hospital, Antrim, UK.
authors.forename: Paul
authors.initials: P
authors.lastname: Johnston
authors.affiliation: Intensive Care Unit, Altnagelvin Area Hospital, Londonderry, UK.
authors.forename: Michaeline
authors.initials: M
authors.lastname: Kelly
authors.affiliation: Intensive Care Unit, Belfast City Hospital, Belfast, UK.
authors.forename: John
authors.initials: J
authors.lastname: McCaffrey
authors.affiliation: Regional Intensive Care Unit, Royal Victoria Hospital, Belfast, UK.
authors.forename: Brian
authors.initials: B
authors.lastname: Mullan
authors.affiliation: Regional Intensive Care Unit, Royal Victoria Hospital, Belfast, UK.
authors.forename: Sally
authors.initials: S
authors.lastname: Murphy
authors.affiliation: Intensive Care Unit, Ulster Hospital, Dundonald, UK.
authors.forename: T John
authors.initials: TJ
authors.lastname: Trinder
authors.affiliation: Regional Intensive Care Unit, Royal Victoria Hospital, Belfast, UK.
authors.forename: Gavin
authors.initials: G
authors.lastname: Lavery
authors.affiliation: Centre Experimental Medicine, School of Medicine, Dentistry & Biomedical Sciences, Queen's University Belfast, Northern Ireland, UK.|Northern Ireland Clinical Trials Unit, Belfast, UK.|Regional Intensive Care Unit, Royal Victoria Hospital, Belfast, UK.
authors.forename: Daniel F
authors.initials: DF
authors.lastname: McAuley
authors.affiliation: Centre Experimental Medicine, School of Medicine, Dentistry & Biomedical Sciences, Queen's University Belfast, Northern Ireland, UK.
authors.forename: Judy M
authors.initials: JM
authors.lastname: Bradley
mesh_terms: D000328:Adult; D000368:Aged; D016638:Critical Illness / Q000534:rehabilitation*; D015444:Exercise / Q000502:physiology* / Q000523:psychology; D005081:Exercise Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010351:Patient Discharge; D011446:Prospective Studies; D020377:Self Efficacy; D016037:Single-Blind Method; D011795:Surveys and Questionnaires; D013997:Time Factors; D000070857:Walk Test
keywords: Exercise