title: The Ties That Bind: Mapping the Dynamic Enhancer-Promoter Interactome.
abstract: Coupling chromosome conformation capture to molecular enrichment for promoter-containing DNA fragments enables the systematic mapping of interactions between individual distal regulatory sequences and their target genes. In this Minireview, we describe recent progress in the application of this technique and related complementary approaches to gain insight into the lineage- and cell-type-specific dynamics of interactions between regulators and gene promoters.
authors.affiliation: MS 84-171, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
authors.forename: Cailyn H
authors.initials: CH
authors.lastname: Spurrell
authors.affiliation: MS 84-171, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
authors.forename: Diane E
authors.initials: DE
authors.lastname: Dickel
authors.affiliation: MS 84-171, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA; U.S. Department of Energy Joint Genome Institute, Walnut Creek, CA 94598, USA; School of Natural Sciences, University of California, Merced, CA 95343, USA. Electronic address: avisel@lbl.gov.
authors.forename: Axel
authors.initials: A
authors.lastname: Visel
mesh_terms: D004194:Disease / Q000235:genetics; D004742:Enhancer Elements, Genetic; D057890:Epigenomics; D005786:Gene Expression Regulation; D006801:Humans; D009928:Organ Specificity; D011401:Promoter Regions, Genetic