title: The Ly6C(lo)-Down: Targeting Developmental Enhancers for Cell Subset Depletion.
abstract: The diversity of mononuclear phagocytes has made it difficult to ascribe cellular functions to sub-populations using conventional loss-of-function approaches. In this issue of Immunity, Thomas et al. (2016) highlight the value of excising enhancer domains, effectively depleting defined lineages without altering other cellular physiology.
authors.affiliation: Department of Microbiology, Immunology, and Molecular Genetics, and Molecular Biology Institute, University of California, Los Angeles, CA 90095, USA.
authors.forename: Brandon J
authors.initials: BJ
authors.lastname: Thomas
authors.affiliation: Department of Microbiology, Immunology, and Molecular Genetics, and Molecular Biology Institute, University of California, Los Angeles, CA 90095, USA. Electronic address: smale@mednet.ucla.edu.
authors.forename: Stephen T
authors.initials: ST
authors.lastname: Smale
mesh_terms: D006801:Humans; D009000:Monocytes / Q000276:immunology*; D012045:Regulatory Sequences, Nucleic Acid