title: Cognitive 'Omics': Pattern-Based Validation of Potential Drug Targets.
abstract: Despite the abundance of cognitive enhancer mechanisms identified in basic research, drugs approved for cognitive disorders are scarce and of limited efficacy. Although the so-called 'gold-standard' animal assays are well suited to the study of fundamental learning processes, they fail to predict clinical efficacy against complex and robust cognitive defects. Preclinical validation of potential drug targets requires new approaches with higher translational value. Here I propose a rodent cognitive test system that encompasses several learning paradigms each modeling a certain human cognitive domain. Cognitive deficits are brought about by several impairing methods and a particular mechanism of action is tested on each defective cognitive function. The outcome is a cognitive efficacy pattern that should then be matched to the cognitive deficit patterns of the clinical disorders. The best fit will highlight the clinical indication with the greatest chance for success.
authors.affiliation: MTA-SE NAP B Cognitive Translational Behavioural Pharmacology Group, Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary; Institute of Cognitive Neuroscience and Psychology, Research Center for Natural Sciences, MTA, Budapest, Hungary. Electronic address: gyertyan.istvan@med.semmelweis-univ.hu.
authors.forename: István
authors.initials: I
authors.lastname: Gyertyán
mesh_terms: D000818:Animals; D003071:Cognition / Q000187:drug effects; D003072:Cognition Disorders / Q000188:drug therapy*; D055808:Drug Discovery; D006801:Humans; D007858:Learning / Q000187:drug effects; D023421:Models, Animal; D018579:Patient Selection
keywords: animal models; cognitive enhancers; memory and cognitive disorders; translational validity