title: Evaluation of Role of Myofibroblasts in Oral Cancer: A Systematic Review.
abstract: OBJECTIVE
  To conduct a systematic review on the role of myofibroblasts in progression of oral cancer. The myofibroblast is essential for the integrity of the mammalian body by virtue of its role in wound healing, but it also plays a negative role due to their role in promoting tumor development.
  
  
  METHODS
  Systematic review.
  
  
  METHODS
  Bibliographic searches were conducted in several electronic databases using all publications in PubMed, PubMed central, EMBASE, CancerLit, Google scholar, and Cochrane CCTR between 1990 and June 2015.
  
  
  RESULTS
  The search of all publications from various electronic databases revealed 1,371 citations. The total number of studies considered for systematic review was 43. The total number of patients included in the studies was 990.
  
  
  CONCLUSIONS
  Myofibroblasts are a significant component in stroma of oral cancer cases, though not identified in all cases. This systematic review shows that clinical, pathological, and immunohistochemistry tests have correlated the presence of high myofibroblast count in oral cancer cell stroma.
  
  
  CONCLUSIONS
  Myofibroblasts play a significant role in oral cancer invasion and progression. Various studies have demonstrated their association with oral cancer. This review tends to highlight their role in the pathogenesis of oral cancer over the decade.
  Sekhon HK, Sircar K, Kaur G, Marwah M. Evaluation of Role of Myofibroblasts in Oral Cancer: A Systematic Review. Int J Clin Pediatr Dent 2016;9(3):233-239.
authors.affiliation: Senior Lecturer, Department of Oral Pathology and Microbiology, D.J. College of Dental Sciences & Research, Modinagar, Uttar Pradesh, India.
authors.forename: Harjeet K
authors.initials: HK
authors.lastname: Sekhon
authors.affiliation: Head, Department of Oral Pathology and Microbiology, Faculty of Dentistry, Jamia Millia Islamia, New Delhi, India.
authors.forename: Keya
authors.initials: K
authors.lastname: Sircar
authors.affiliation: Ex-post Graduate Student, Department of Periodontology, Dr. D.Y. Patil Dental College and Hospital, Dr. D.Y. Patil Vidyapeeth, Pune, Maharashtra, India.
authors.forename: Gurbani
authors.initials: G
authors.lastname: Kaur
authors.affiliation: Postgraduate, Department of Prosthodontics, Government Dental College Thiruvananthapuram, Kerala, India.
authors.forename: Muneet
authors.initials: M
authors.lastname: Marwah
keywords: Myofibroblast; Oral cancer; Precancer.