title: Efficacy of micellized vs. fat-soluble vitamin D3 supplementation in healthy school children from Northern India.
abstract: BACKGROUND
  Vitamin D deficiency is a widely recognized public health problem. Efficacy of a recently developed micellized form of vitamin D3 has not been studied. Hence, we undertook this study to compare its efficacy with the conventionally used fat-soluble vitamin D3.
  
  
  METHODS
  In this open-labeled nonrandomized pilot study, we recruited 180 healthy children, aged 13-14 years in two groups and supplemented Group A (60 children) with 60,000 IU of fat-soluble vitamin D3/month with milk and Group B (120 children) with 60,000 IU/month of water miscible vitamin D3 under supervision for 6 months. Serum 25(OD)D, parathyroid hormone (PTH), calcium, phosphate, and alkaline phosphatase (ALP) levels were evaluated before and after supplementation in 156 children (54 in Group A and 102 in Group B) who completed the study.
  
  
  RESULTS
  We observed a significantly greater increase in the serum 25(OH)D levels in group B as compared to group A (31.8±9.1 ng/mL vs. 23.7±10.4 ng/mL; p<0.001). All children in group B achieved adequate levels of serum 25(OH)D (>20 ng/mL) as against 83.3% children in group A. Serum PTH and ALP levels declined considerably in both the groups following supplementation.
  
  
  CONCLUSIONS
  Vitamin D supplementation significantly increased the serum 25(OH)D levels in both groups. Miscible form of vitamin D3 appears to be better in achieving higher levels of serum 25(OH)D than that observed with a similar dose of fat-soluble vitamin D3. Further studies with different dose regimens are required to establish its efficacy over the conventionally used fat-soluble vitamin D3.
authors.forename: Raman K
authors.initials: RK
authors.lastname: Marwaha
authors.forename: Vamsi K
authors.initials: VK
authors.lastname: Yenamandra
authors.forename: Mohammed Asraf
authors.initials: MA
authors.lastname: Ganie
authors.forename: Gomathy
authors.initials: G
authors.lastname: Sethuraman
authors.forename: Vishnubhatla
authors.initials: V
authors.lastname: Sreenivas
authors.forename: Lakshmy
authors.initials: L
authors.lastname: Ramakrishnan
authors.forename: Sathish K
authors.initials: SK
authors.lastname: Mathur
authors.forename: Vinod K
authors.initials: VK
authors.lastname: Sharma
authors.forename: Ambrish
authors.initials: A
authors.lastname: Mithal
mesh_terms: D000293:Adolescent; D002648:Child; D002762:Cholecalciferol / Q000008:administration & dosage*; D019587:Dietary Supplements; D005227:Fatty Acids / Q000737:chemistry*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007194:India; D008297:Male; D008823:Micelles; D010865:Pilot Projects; D011379:Prognosis; D014807:Vitamin D / Q000008:administration & dosage*; D014808:Vitamin D Deficiency / Q000517:prevention & control*
chemical_list: D005227:Fatty Acids; D008823:Micelles; D014807:Vitamin D; D002762:Cholecalciferol