title: White blood cell subtypes and risk of type 2 diabetes.
abstract: It is reported that total white blood cell is associated with risk of diabetes mellitus. The present study is to investigate the relationship of white blood cell subsets with incidence of type 2 diabetes at baseline and 3year follow-up.
  
  
  
  We chose individuals without diabetes history as our study population; 8991 individuals were included at baseline. All of the participants underwent a 75-g OGTT at baseline. White blood cell count including all the subsets were measured along with all the other laboratory indices. The participants who were not diagnosed with type 2 diabetes according to the WHO 1999 diagnostic criteria underwent another 75-g OGTT at 3year follow-up.
  
  
  
  The total WBC count, neutrophil count, and lymphocyte count were significantly increased in subjects newly diagnosed with diabetes mellitus compared to non-DM subjects at baseline (all p<0.001). The ORs for DM were increased from the 1st to the 4th quartiles at both baseline and follow-up (both p<0.001 for trend). At baseline, in the highest WBC quartile, the adjusted OR of DM was 2.51 (95% confidence interval [CI] 2.09 to 3.02). In the highest neutrophils quartile, the adjusted OR of DM was 2.11 (95% confidence interval [CI] 1.78 to 2.51). In the highest lymphocytes quartile, the adjusted OR of DM was 1.85 (95% confidence interval [CI] 1.56 to 2.18). At follow-up, in the highest WBC quartile, the adjusted OR of DM was 1.79 (95% confidence interval [CI] 1.38 to 2.33). In the highest neutrophils quartile, the adjusted OR of DM was 1.58 (95% confidence interval [CI] 1.23 to 2.03). In the highest lymphocytes quartile, the adjusted OR of DM was 1.74 (95% confidence interval [CI] 1.37 to 2.22). HOMA-IR and HbA1c correlated to elevated levels of WBC count, neutrophils and lymphocytes significantly (all p<0.001).
  
  
  
  Increased levels of WBC count, neutrophils and lymphocytes are all predictors for incidence of type 2 diabetes.
authors.affiliation: Department of Endocrinology, Xinhua Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China.
authors.forename: Hongmei
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Endocrinology, Xinhua Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Yang
authors.affiliation: Department of Endocrinology, Xinhua Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China.
authors.forename: Weiwei
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Department of Endocrinology, Xinhua Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China.
authors.forename: Yixin
authors.initials: Y
authors.lastname: Niu
authors.affiliation: Department of Endocrinology, Xinhua Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China.
authors.forename: Xiaoyong
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Endocrinology, Xinhua Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China. Electronic address: qinli@medmail.com.cn.
authors.forename: Li
authors.initials: L
authors.lastname: Qin
authors.affiliation: Department of Endocrinology, Xinhua Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China. Electronic address: suqingxinhua@163.com.
authors.forename: Qing
authors.initials: Q
authors.lastname: Su
mesh_terms: D000328:Adult; D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D015994:Incidence; D007958:Leukocyte Count; D007962:Leukocytes / Q000145:classification / Q000473:pathology*; D008214:Lymphocytes / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000473:pathology; D012307:Risk Factors
chemical_list: D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human
keywords: Diabetes; Lymphocytes; Neutrophil:lymphocyte ratio; Neutrophils; White blood cell count