title: Synchronous Malignant Peripheral Nerve Sheath Tumor and Adenocarcinoma of the Prostate: Case Report and Literature Review.
abstract: Malignant Peripheral Nerve Sheath Tumors (MPNSTs) of the prostate are extremely rare. A very unusual case of simultaneous adenocarcinoma and MPNST of the prostate is reported. A 60-year-old Caucasian male presented for annual urologic examination. Digital rectal examination revealed a painless, toughish, and asymmetrically enlarged prostate. Serum prostate-specific antigen was 1 ng/mL. Radiologic examinations demonstrated a large mass, which was arising from the left peripheral lobe of the prostate. The patient underwent transrectal ultrasound-guided biopsy of the prostate which revealed a smooth muscle tumor of uncertain malignant potential. Radical retropubic prostatectomy with en bloc removal of the mass and the seminal vesicles was performed and histology demonstrated low-grade MPNST and adenocarcinoma of the prostate. To the best of our knowledge, this is the first report of simultaneous prostatic adenocarcinoma and MPNST in the English literature.
authors.affiliation: Department of Urology, Korgialenio-Benakio Hellenic Red Cross Hospital, Athanasaki 1, 115 26 Athens, Greece.
authors.forename: Nikolaos
authors.identifier: 0000-0002-5730-7308
authors.initials: N
authors.lastname: Ferakis
authors.affiliation: Department of Urology, Korgialenio-Benakio Hellenic Red Cross Hospital, Athanasaki 1, 115 26 Athens, Greece.
authors.forename: Antonios
authors.identifier: 0000-0003-4695-7724
authors.initials: A
authors.lastname: Katsimantas
authors.affiliation: Department of Urology, Korgialenio-Benakio Hellenic Red Cross Hospital, Athanasaki 1, 115 26 Athens, Greece.
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Bouropoulos
authors.affiliation: Department of Urology, Korgialenio-Benakio Hellenic Red Cross Hospital, Athanasaki 1, 115 26 Athens, Greece.
authors.forename: Antonios
authors.initials: A
authors.lastname: Farmakis