title: Optical weak measurement system with common path implementation for label-free biomolecule sensing.
abstract: A reflection-type phase-sensitive weak measurement for biosensing and chemical label-free sensing is presented. The phase difference between p and s polarizations in total internal reflection caused by biomolecular recognition is measured by weak value amplification. The system with p and s polarizations in a common path is stable and robust. The sensing process occurring on the silicon dioxide surface is achieved with a resolution of 3.6×10-6refractive index units. The applicability is demonstrated by real-time monitoring biomolecular interaction of IgG and protein A.
authors.forename: Yilong
authors.initials: Y
authors.lastname: Zhang
authors.forename: Dongmei
authors.initials: D
authors.lastname: Li
authors.forename: Yonghong
authors.initials: Y
authors.lastname: He
authors.forename: Zhiyuan
authors.initials: Z
authors.lastname: Shen
authors.forename: Qinghua
authors.initials: Q
authors.lastname: He
mesh_terms: D015374:Biosensing Techniques; D004867:Equipment Design; D055096:Optical Devices; D055095:Optics and Photonics; D012031:Refractometry; D012825:Silicon / Q000737:chemistry; D012822:Silicon Dioxide
chemical_list: D012822:Silicon Dioxide; D012825:Silicon