title: Accelerating MRI fat quantification using a signal model-based dictionary to assess gastric fat volume and distribution of fat fraction.
abstract: To quantify intragastric fat volume and distribution with accelerated magnetic resonance (MR) imaging using signal model-based dictionaries (DICT) in comparison to conventional parallel imaging (CG-SENSE). This study was approved by the local ethics committee and written informed consent was obtained. Seven healthy subjects were imaged after intake of a lipid emulsion and data at three different time points during the gastric emptying process was acquired in order to cover a range of fat fractions. Fully sampled and prospectively undersampled image data at a reduction factor of 4 were acquired using a multi gradient echo sequence at 1.5T. Retrospectively and prospectively undersampled data were reconstructed with DICT and CG-SENSE. Image quality of the retrospectively undersampled data was assessed relative to the fully sampled reference using the root mean square error (RMSE). In order to assess the agreement of fat volumes and intragastric fat distribution, Bland-Altman analysis and linear regression were performed on the data. The RMSE in intragastric content (ΔRMSE=0.10±0.01, P<0.001) decreased significantly with DICT relative to CG-SENSE. CG-SENSE overestimated fat volumes (bias 2.1±1.3mL; confidence limits 5.4 and -1.1mL) in comparison to the prospective DICT reconstruction (bias -0.1±0.7mL; confidence limits 1.8 and -2.0mL). There was a good agreement in fat distribution between the images reconstructed by retrospective DICT and the reference images (regression slope: 1.01, R2=0.961). Accelerating gastric MRI by integrating a dictionary-based signal model allows for improved image quality and increases accuracy of fat quantification during breathholds.
authors.affiliation: Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland.
authors.forename: Dian
authors.initials: D
authors.lastname: Liu
authors.affiliation: Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland; Division of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland.
authors.forename: Andreas
authors.initials: A
authors.lastname: Steingoetter
authors.affiliation: Division of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland.
authors.forename: Helen L
authors.initials: HL
authors.lastname: Parker
authors.affiliation: Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland; Division of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland.
authors.forename: Jelena
authors.initials: J
authors.lastname: Curcic
authors.affiliation: Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland. Electronic address: kozerke@biomed.ee.ethz.ch.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Kozerke
mesh_terms: D000328:Adult; D005260:Female; D005746:Gastric Emptying / Q000502:physiology*; D005766:Gastrointestinal Contents / Q000000981:diagnostic imaging*; D041981:Gastrointestinal Tract / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000502:physiology; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D016014:Linear Models; D050356:Lipid Metabolism / Q000502:physiology*; D008055:Lipids / Q000008:administration & dosage; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D011446:Prospective Studies; D012016:Reference Values; D012189:Retrospective Studies; D012815:Signal Processing, Computer-Assisted; D055815:Young Adult
chemical_list: D008055:Lipids
keywords: Compressed sensing; Fat digestion; Fat quantification; Gastric emptying; Parallel imaging; Water-fat separation