title: Diagnosis of del(5q) MDS, 14 Years after JAK-2 Positive PV Appearance: Complete Remission of both Diseases with Lenalidomide Monotherapy.
abstract: This is the report of the clinical case of a patient who presents the association of a JAK-2 positive chronic myeloproliferative neoplasia to a subsequent 5q- myelodysplastic syndrome, developed after about 14 years from the first diagnosis. Patient's symptoms had rapidly worsened, and she became transfusion-dependent. Therapy with low-dose Lenalidomide quickly reduced the splenomegaly and completely brought white cells counts, haemoglobin, and platelets back to normal. After more than one year from the start, blood cell count is still normal. As far as we know, this is the first case of an effective treatment with Lenalidomide reported in this clinical setting.
authors.affiliation: Rare Diseases, Immunology, Immunohaematology and Haematology Department, San Giovanni Bosco Hospital, Turin, Italy.
authors.forename: Antonella
authors.initials: A
authors.lastname: Vaccarino
authors.affiliation: Rare Diseases, Immunology, Immunohaematology and Haematology Department, San Giovanni Bosco Hospital, Turin, Italy.
authors.forename: Irene
authors.initials: I
authors.lastname: Dogliotti
authors.affiliation: Rare Diseases, Immunology, Immunohaematology and Haematology Department, San Giovanni Bosco Hospital, Turin, Italy.
authors.forename: Fabio
authors.initials: F
authors.lastname: Marletto
authors.affiliation: Pathology Unit, San Giovanni Bosco Hospital, Turin, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Demarchi
authors.affiliation: Rare Diseases, Immunology, Immunohaematology and Haematology Department, San Giovanni Bosco Hospital, Turin, Italy.
authors.forename: Mario
authors.initials: M
authors.lastname: Bazzan