title: Magnesium alloy covered stent for treatment of a lateral aneurysm model in rabbit common carotid artery: An in vivo study.
abstract: Magnesium alloy covered stents have rarely been used in the common carotid artery (CCA). We evaluated the long-term efficacy of magnesium alloy covered stents in a lateral aneurysm model in rabbit CCA. Magnesium alloy covered stents (group A, n = 7) or Willis covered stents (group B, n = 5) were inserted in 12 New Zealand White rabbits and they were followed up for 12 months. The long-term feasibility for aneurysm occlusion was studied through angiograms; the changes in vessel area and lumen area were assessed with IVUS. Complete aneurysmal occlusion was achieved in all aneurysms. Angiography showed that the diameter of the stented CCA in group A at 6 and 12 months was significantly greater than the diameter immediately after stent placement. On intravascular ultrasound (IVUS) examination, the mean lumen area of the stented CCA in group A was significantly greater at 6 and 12 months than that immediately after stent placement; the mean lumen area was also significantly greater in group A than in group B at the same time points. The magnesium alloy covered stents proved to be an effective approach for occlusion of lateral aneurysm in the rabbit CCA; it provides distinct advantages that are comparable to that obtained with the Willis covered stent.
authors.affiliation: Institute of Diagnostic and Interventional Radiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China.
authors.forename: Wu
authors.initials: W
authors.lastname: Wang
authors.affiliation: Department of Interventional Radiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, (Fengxian Hospital), Shanghai, China.
authors.forename: Yong-Li
authors.initials: YL
authors.lastname: Wang
authors.affiliation: Institute of Diagnostic and Interventional Radiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China.
authors.forename: Mo
authors.initials: M
authors.lastname: Chen
authors.affiliation: Department of Interventional Radiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, (Fengxian Hospital), Shanghai, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Chen
authors.affiliation: National Engineering Research Center of Light Alloy Net Forming and State Key Laboratory of Metal Matrix Composite, Shanghai Jiao Tong University, Shanghai 200240, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Institute of Diagnostic and Interventional Radiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China.
authors.forename: Yong-Dong
authors.initials: YD
authors.lastname: Li
authors.affiliation: Institute of Diagnostic and Interventional Radiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China.
authors.forename: Ming-Hua
authors.initials: MH
authors.lastname: Li
authors.affiliation: National Engineering Research Center of Light Alloy Net Forming and State Key Laboratory of Metal Matrix Composite, Shanghai Jiao Tong University, Shanghai 200240, China.
authors.forename: Guang-Yin
authors.initials: GY
authors.lastname: Yuan
mesh_terms: D000497:Alloys / Q000494:pharmacology*; D000783:Aneurysm / Q000473:pathology / Q000628:therapy*; D000818:Animals; D017536:Carotid Artery, Common / Q000000981:diagnostic imaging / Q000473:pathology*; D004195:Disease Models, Animal; D005260:Female; D005500:Follow-Up Studies; D020007:Implants, Experimental; D008274:Magnesium / Q000494:pharmacology*; D018810:Magnetic Resonance Angiography; D008297:Male; D008982:Molybdenum / Q000494:pharmacology; D011817:Rabbits; D015607:Stents; D018084:Ultrasonography, Interventional
chemical_list: D000497:Alloys; D008982:Molybdenum; D008274:Magnesium