title: Comparison of Two Diagnostic Scores of Disseminated Intravascular Coagulation in Pregnant Women Admitted to the ICU.
abstract: OBJECTIVE
  To compare the validity of two previously published diagnostic scores of disseminated intravascular coagulation (DIC) in pregnant women admitted to ICU for an acute thrombotic or hemorrhagic complication of delivery and postpartum.
  
  
  METHODS
  This was a population based retrospective study of 154 patients admitted to ICU for severe delivery and postpartum complications in a University Hospital. A recently published score (adapted to physiological changes of pregnancy and based on three components: platelet count, prothrombin time difference and fibrinogen) was compared to the International Society for Thrombosis and Hemostasis (ISTH) score (based on four components: platelet count, fibrinogen, prothrombin time, and fibrin related marker). Both scores were calculated at delivery, ICU admission (day 0), day 1 and day 2 during the postpartum ICU stay. The validity of both scores was assessed by comparison with the consensual and blinded analysis of two experts. The sensitivity, specificity, and area under the curve (AUC) of each score were calculated at each time and overall by generalized linear mixed model. The agreement between the two scores was evaluated by the Kappa coefficient.
  
  
  RESULTS
  The new score had a sensitivity of 0.78, a specificity of 0.97 (p <0.01) and a global AUC of 96% while the ISTH score had a sensitivity of 0.31, a specificity of 0.99 and an AUC of 94% (p <0.01). The Kappa coefficient of correlation between both scores was 0.35. The lower sensitivity of the ISTH score was mainly explained by the lack of fibrinogen and fibrin-related peptides thresholds adapted to the physiological changes of coagulation induced by pregnancy.
  
  
  CONCLUSIONS
  The new DIC score seem highly discriminant in the subset of patients admitted to the ICU after delivery for an acute specific complication. The ISTH score is not recommended in pregnant women because of its poor sensitivity.
authors.affiliation: Department of Intensive Care Unit, Centre Hospitalier du Dr. Schaffner, Lens and Centre hospitalier Roger Salengro, Centre Hospitalier Regional Universitaire, Lille, France.
authors.forename: Marie
authors.initials: M
authors.lastname: Jonard
authors.affiliation: Department of Obstetric Anesthesia, Centre Hospitalier Regional Universitaire, Lille, France.
authors.forename: Anne Sophie
authors.initials: AS
authors.lastname: Ducloy-Bouthors
authors.affiliation: Department of Intensive Care Unit, Centre hospitalier Roger Salengro, Centre Hospitalier Regional Universitaire, Lille, France.
authors.forename: François
authors.initials: F
authors.lastname: Fourrier
mesh_terms: D000328:Adult; D001780:Blood Coagulation Tests; D004211:Disseminated Intravascular Coagulation / Q000175:diagnosis* / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D006760:Hospitalization; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D011159:Population Surveillance; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000175:diagnosis* / Q000453:epidemiology*; D012372:ROC Curve; D012016:Reference Values; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index