title: 13-Methyltetradecanoic acid mitigates cerebral ischemia/reperfusion injury.
abstract: 13-Methyltetradecanoic acid can stabilize cell membrane and have anti-inflammatory, antioxidant and anti-apoptotic effects. Previous studies mainly focused on peripheral nerve injury, but seldom on the central nervous system. We investigated whether these properties of 13-methyltetradecanoic acid have a neuroprotective effect on focal cerebral ischemia/reperfusion injury, and detected the expression of basic fibroblast growth factor and vascular endothelial growth factor. This study established rat models of middle cerebral artery occlusion/reperfusion injury by ischemia for 2 hours and reperfusion for 24 hours. At the beginning of reperfusion, 13-methyltetradecanoic acid 10, 40 or 80 mg/kg was injected into the tail vein. Results found that various doses of 13-methyltetradecanoic acid effectively reduced infarct volume, mitigate cerebral edema, and increased the mRNA and protein expression of basic fibroblast growth factor and vascular endothelial growth factor at 24 hours of reperfusion. The effect was most significant in the 13-methyltetradecanoic acid 40 and 80 mg/kg groups. The findings suggest that 13-methyltetradecanoic acid can relieve focal ischemia/reperfusion injury immediately after reperfusion, stimulate the upregulation of basic fibroblast growth factor and vascular endothelial growth factor to exert neuroprotective effects.
authors.affiliation: Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, Fujian Province, China.
authors.forename: Juan
authors.identifier: 0000-0002-7264-6463
authors.initials: J
authors.lastname: Yu
authors.affiliation: Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, Fujian Province, China.
authors.forename: Li-Nan
authors.initials: LN
authors.lastname: Yang
authors.affiliation: Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, Fujian Province, China.
authors.forename: Yan-Yun
authors.initials: YY
authors.lastname: Wu
authors.affiliation: Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, Fujian Province, China.
authors.forename: Bao-Hua
authors.initials: BH
authors.lastname: Li
authors.affiliation: Department of Pharmacology, School of Pharmacy, Fujian Medical University, Fuzhou, Fujian Province, China.
authors.forename: Sheng-Mei
authors.initials: SM
authors.lastname: Weng
authors.affiliation: Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, Fujian Province, China.
authors.forename: Chun-Lan
authors.initials: CL
authors.lastname: Hu
authors.affiliation: Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, Fujian Province, China.
authors.forename: Yong-Ling
authors.initials: YL
authors.lastname: Han
keywords: 13-methyltetradecanoic acid; basic fibroblast growth factor; brain injury; cerebral infarction; cerebral edema; cerebral ischemia/reperfusion injury; nerve regeneration; neural regeneration; vascular endothelial growth factor