title: The Role of Caffeine in Noninvasive Respiratory Support.
abstract: Caffeine is one of the most commonly prescribed medications in preterm neonates and is widely used to treat or prevent apnea of prematurity. Caffeine therapy is safe, effectively decreases apnea, and improves short- and long-term outcomes in preterm infants. In this review, the authors summarize the role of caffeine therapy for preterm infants receiving noninvasive respiratory support. As caffeine is already widely used, recent data are summarized that may guide clinicians in optimizing the use of caffeine therapy, with a review of the timing of initiation, dose, and duration of therapy.
authors.affiliation: Department of Pediatrics, Uniformed Services University of Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA.
authors.forename: Nicole R
authors.initials: NR
authors.lastname: Dobson
authors.affiliation: Division of Neonatal-Perinatal Medicine, Department of Pediatrics, Emory University School of Medicine, Children's Healthcare of Atlanta, 2015 Uppergate Drive Northeast, 3rd Floor, Atlanta, GA 30322, USA. Electronic address: rmpatel@emory.edu.
authors.forename: Ravi Mangal
authors.initials: RM
authors.lastname: Patel
mesh_terms: D001049:Apnea / Q000188:drug therapy*; D001997:Bronchopulmonary Dysplasia / Q000453:epidemiology; D002110:Caffeine / Q000627:therapeutic use*; D000697:Central Nervous System Stimulants / Q000627:therapeutic use*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D063087:Noninvasive Ventilation / Q000379:methods*; D012127:Respiratory Distress Syndrome, Newborn / Q000628:therapy*
chemical_list: D000697:Central Nervous System Stimulants; D002110:Caffeine
keywords: Apnea; Bronchopulmonary dysplasia; Caffeine; Noninvasive ventilation; Premature infant