title: A retrospective analysis of cardiovascular outcomes in patients treated with ASV.
abstract: OBJECTIVE
  The effect of long-term adaptive servo-ventilation (ASV) on cardiovascular mortality and admission rates in patients with chronic heart failure (CHF) and Cheyne-Stokes respiration (CSR) has not been much studied. The aim of this study was primarily to investigate whether ASV therapy significantly reduced these parameters.
  
  
  METHODS
  We included 75 CHF patients on optimal medication and CSR ≥25% of sleeping time, in New York Heart Association (NYHA) classes II-IV and left ventricular ejection fraction (LVEF) ≤ 45%. Thirty-one patients were treated with ASV for >3-18 months and 44 patients served as a control group.
  
  
  RESULTS
  Seven deaths (16%) in the control group and one death (3%) in the ASV treatment group had cardiovascular etiology. There was no significant difference between the two groups regarding cardiovascular death (log rank p = 0.07; HR 0.18 (95% CI 0.02-1.44), p = 0.11) and combined cardiovascular death or readmissions, but there was a trend toward better outcome regarding cardiovascular event-free survival (log rank p = 0.06; HR 0.53 (95% CI 0.27-1.05).
  
  
  CONCLUSIONS
  In CHF patients with CSR, 18 months ASV treatment did not significantly affect cardiovascular death or combined cardiovascular death or hospital admissions. But there was a trend toward better combined outcome.
authors.affiliation: a The Hospital of Østfold , Fredrikstad , Norway.|b University of Oslo , Oslo , Norway.
authors.forename: Arild
authors.initials: A
authors.lastname: Hetland
authors.affiliation: b University of Oslo , Oslo , Norway.|c Department of Cardiology and Center for Cardiological Innovation, Oslo University Hospital Rikshospitalet , Oslo , Norway.
authors.forename: Kristina H
authors.initials: KH
authors.lastname: Haugaa
authors.affiliation: a The Hospital of Østfold , Fredrikstad , Norway.|d Department of Internal Medicine , Diakonhjemmet Hospital , Oslo , Norway.
authors.forename: Maria
authors.initials: M
authors.lastname: Vistnes
authors.affiliation: e Department of Chemistry, Biotechnology and Food Sciences, Norwegian University of Life Sciences , Ås , Norway.
authors.forename: Kristian Hovde
authors.initials: KH
authors.lastname: Liland
authors.affiliation: a The Hospital of Østfold , Fredrikstad , Norway.
authors.forename: Margareth
authors.initials: M
authors.lastname: Olseng
authors.affiliation: a The Hospital of Østfold , Fredrikstad , Norway.|b University of Oslo , Oslo , Norway.
authors.forename: Morten B
authors.initials: MB
authors.lastname: Jacobsen
authors.affiliation: b University of Oslo , Oslo , Norway.|c Department of Cardiology and Center for Cardiological Innovation, Oslo University Hospital Rikshospitalet , Oslo , Norway.
authors.forename: Thor
authors.initials: T
authors.lastname: Edvardsen
mesh_terms: D000368:Aged; D002423:Cause of Death; D002639:Cheyne-Stokes Respiration / Q000175:diagnosis / Q000401:mortality / Q000503:physiopathology / Q000628:therapy*; D002908:Chronic Disease; D018450:Disease Progression; D018572:Disease-Free Survival; D005260:Female; D006333:Heart Failure / Q000175:diagnosis / Q000401:mortality / Q000503:physiopathology / Q000628:therapy*; D006439:Hemodynamics; D006801:Humans; D053208:Kaplan-Meier Estimate; D008168:Lung / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010343:Patient Admission; D016016:Proportional Hazards Models; D012121:Respiration, Artificial / Q000009:adverse effects / Q000379:methods* / Q000401:mortality; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome
keywords: Heart failure; adaptive servo-ventilation; mortality