title: Cerebellum-from J. E. Purkyně up to Contemporary Research.
abstract: Jan. Evangelista Purkyně, the most famous among Czech physiologists, was the first who identified and described the largest nerve cells in the cerebellum. The most distinguished researchers of the nervous system then recommended naming these neurons Purkinje cells in his honor. Through experiments by Purkinje and his followers, the function of the cerebellum was properly attributed to the precision of motor movements and skills. This traditional concept was valid until early 1990s, when it was readjusted and replenished with new and important findings. It was discovered that the cerebellar cortex contains more neurons than the cerebral cortex and shortly thereafter was gradually revealed that such enormous numbers of neural cells are not without impact on brain functions. It was shown that the cerebellum, in addition to its traditional role, also participates in higher nervous activity. These new findings were obtained thanks to the introduction of modern methods of examination into the clinical praxis, and experimental procedures using animal models of cerebellar disorders described in this work.
authors.affiliation: Department of Pathophysiology, Faculty of Medicine in Pilsen, Charles University, alej Svobody 1655/76, 323 00, Pilsen, Czech Republic. frantisek.vozeh@lfp.cuni.cz.|Laboratory of Neurodegenerative Disorders, Biomedical Centre, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic. frantisek.vozeh@lfp.cuni.cz.
authors.forename: František
authors.initials: F
authors.lastname: Vožeh
mesh_terms: D000818:Animals; D002525:Cerebellar Cortex / Q000503:physiopathology*; D002526:Cerebellar Diseases / Q000503:physiopathology*; D002531:Cerebellum / Q000503:physiopathology*; D006801:Humans; D023421:Models, Animal; D011689:Purkinje Cells / Q000502:physiology*; D012106:Research
keywords: Animal models; Ataxia; Cerebellar degeneration; Cerebellum; Neurodegeneration; Purkinje cells; SCA models