title: Salt metathesis for developing injectable supramolecular metallohydrogelators as a multi-drug-self-delivery system.
abstract: Salt metathesis has been exploited to generate a series of non-steroidal anti-inflammatory drug (NSAID) based Zn(ii) metallohydrogels displaying both anti-inflammatory and anti-bacterial properties. Relatively low cytotoxicity, rheoreversibility and injectibility of one of these hydrogels make it suitable for multi-drug-self-delivery application.
authors.affiliation: Department of Organic Chemistry, Indian Association for the Cultivation of Science (IACS), 2A and 2B, Raja S. C. Mullick Road, Jadavpur, Kolkata - 700032, West Bengal, India. ocpd@iacs.res.in.
authors.forename: Rajdip
authors.initials: R
authors.lastname: Roy
authors.forename: Meduri
authors.initials: M
authors.lastname: Bhagyalalitha
authors.forename: Pritam
authors.initials: P
authors.lastname: Choudhury
authors.forename: Parthasarathi
authors.initials: P
authors.lastname: Dastidar
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D016503:Drug Delivery Systems; D020100:Hydrogels / Q000138:chemical synthesis / Q000737:chemistry*; D007249:Inflammation / Q000188:drug therapy; D046911:Macromolecular Substances / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology; D051379:Mice; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D000067996:RAW 264.7 Cells; D012492:Salts / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology; D015032:Zinc / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D020100:Hydrogels; D046911:Macromolecular Substances; D009942:Organometallic Compounds; D012492:Salts; D015032:Zinc