title: Intrinsically Disordered Side of the Zika Virus Proteome.
abstract: Over the last few decades, concepts of protein intrinsic disorder have been implicated in different biological processes. Recent studies have suggested that intrinsically disordered proteins (IDPs) provide structural plasticity and functional diversity to viral proteins that are involved in rapid replication and immune evasion in host cells. In case of Zika virus, the roles of protein intrinsic disorder in mechanisms of pathogenesis are not completely understood. In this study, we have analyzed the prevalence of intrinsic disorder in Zika virus proteome (strain MR 766). Our analyses revealed that Zika virus polyprotein is enriched with intrinsically disordered protein regions (IDPRs) and this finding is consistent with previous reports on the involvement of IDPs in shell formation and virulence of theFlaviviridaefamily. We found abundant IDPRs in Capsid, NS2B, NS3, NS4A, and NS5 proteins that are involved in mature particle formation and replication. In our view, the intrinsic disorder-focused analysis of ZIKV proteins could be important for the development of disorder-based drugs.
authors.affiliation: School of Basic Sciences, Indian Institute of Technology Mandi Mandi, India.
authors.forename: Rajanish
authors.initials: R
authors.lastname: Giri
authors.affiliation: School of Basic Sciences, Indian Institute of Technology Mandi Mandi, India.
authors.forename: Deepak
authors.initials: D
authors.lastname: Kumar
authors.affiliation: School of Basic Sciences, Indian Institute of Technology Mandi Mandi, India.
authors.forename: Nitin
authors.initials: N
authors.lastname: Sharma
authors.affiliation: Department of Molecular Medicine and Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South FloridaTampa, FL, USA; Laboratory of Structural Dynamics, Stability and Folding of Proteins, Institute of Cytology, Russian Academy of SciencesSaint Petersburg, Russia.
authors.forename: Vladimir N
authors.initials: VN
authors.lastname: Uversky
mesh_terms: D019295:Computational Biology; D008958:Models, Molecular; D020815:Polyproteins / Q000737:chemistry*; D011487:Protein Conformation; D014764:Viral Proteins / Q000737:chemistry*; D000071244:Zika Virus / Q000737:chemistry*
chemical_list: D020815:Polyproteins; D014764:Viral Proteins
keywords: Zika virus; cellular proteome; intrinsically disordered protein regions (IDPRs); intrinsically disordered proteins (IDPs); molecular machinery; viral proteome