title: Cerebral Amyloid Deposition Is Associated with Gait Parameters in the Mayo Clinic Study of Aging.
abstract: OBJECTIVE
  To determine the cross-sectional association between cerebral amyloid-beta (Aβ) deposition and gait.
  
  
  METHODS
  Cross-sectional.
  
  
  METHODS
  Population-based cohort study in Olmsted County, MN.
  
  
  METHODS
  Cognitively normal individuals (n = 611), aged 50 to 69 years, enrolled in the Mayo Clinic Study of Aging with concurrent PiB-PET imaging and gait assessment. Participants with a history of stroke, alcoholism, Parkinson's disease, subdural hematoma, traumatic brain injury, or normal pressure hydrocephalus were excluded.
  
  
  METHODS
  PiB-PET SUVR was measured in prefrontal, orbitofrontal, parietal, temporal, anterior cingulate, posterior cingulate, and motor-specific regions of interest (ROIs). Gait parameters (speed, cadence, stride length, double support time, and intra-individual stance time variability) were measured using GAITRite®instrumentation. Linear regression models were adjusted for age, sex, body mass index, education, APOE ε4 allele, Charlson comorbidity index, and depression. In secondary analyses, we additionally adjusted for neurodegeneration (hippocampal volume, FDG PET SUVR, and cortical thickness) in AD-associated regions.
  
  
  RESULTS
  In fully adjusted models including neuroimaging measures of neurodegeneration, higher PiB-PET SUVR across all ROIs was associated with slower gait speed (P < .05 except for the parietal ROI), lower cadence and longer double support time (P ≤ .05 except for the motor ROI), and greater stance time variability (P < .05). In sex-stratified analyses, the association between higher PiB-PET SUVR across all ROIs and measures of gait was only present among women.
  
  
  CONCLUSIONS
  PiB-PET SUVR across ROIs, independent of general measures of AD-associated neurodegeneration, is associated with poorer performance on multiple gait parameters among cognitively normal women, aged 50 to 69 years. Longitudinal studies are needed to determine whether Aβ predicts gait decline in both women and men.
authors.affiliation: Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota.
authors.forename: Alexandra M V
authors.initials: AMV
authors.lastname: Wennberg
authors.affiliation: Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota.|Department of Neurology, Mayo Clinic, Rochester, Minnesota.
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Savica
authors.affiliation: Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota.
authors.forename: Clinton E
authors.initials: CE
authors.lastname: Hagen
authors.affiliation: Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota.|Department of Neurology, Mayo Clinic, Rochester, Minnesota.
authors.forename: Rosebud O
authors.initials: RO
authors.lastname: Roberts
authors.affiliation: Department of Neurology, Mayo Clinic, Rochester, Minnesota.
authors.forename: David S
authors.initials: DS
authors.lastname: Knopman
authors.affiliation: Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, Minnesota.
authors.forename: John H
authors.initials: JH
authors.lastname: Hollman
authors.affiliation: Department of Radiology, Mayo Clinic, Rochester, Minnesota.
authors.forename: Prashanthi
authors.initials: P
authors.lastname: Vemuri
authors.affiliation: Department of Radiology, Mayo Clinic, Rochester, Minnesota.
authors.forename: Clifford R
authors.initials: CR
authors.lastname: Jack
authors.affiliation: Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota.|Department of Neurology, Mayo Clinic, Rochester, Minnesota.
authors.forename: Ronald C
authors.initials: RC
authors.lastname: Petersen
authors.affiliation: Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota.|Department of Neurology, Mayo Clinic, Rochester, Minnesota.
authors.forename: Michelle M
authors.initials: MM
authors.lastname: Mielke
mesh_terms: D000368:Aged; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D003430:Cross-Sectional Studies; D005260:Female; D020233:Gait Disorders, Neurologic / Q000453:epidemiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008910:Minnesota / Q000453:epidemiology; D059906:Neuroimaging; D049268:Positron-Emission Tomography
chemical_list: D016229:Amyloid beta-Peptides
keywords: amyloid-beta; cohort; epidemiology; gait; neuroimaging