title: FUT2 non-secretor status is associated with Type 1 diabetes susceptibility in Japanese children.
abstract: To examine the contribution of the FUT2 gene and ABO blood type to the development of Type 1 diabetes in Japanese children.
  
  
  
  We analysed FUT2 variants and ABO genotypes in a total of 531 Japanese children diagnosed with Type 1 diabetes and 448 control subjects. The possible association of FUT2 variants and ABO genotypes with the onset of Type 1 diabetes was statistically examined.
  
  
  
  The se2 genotype (c.385A>T) of the FUT2 gene was found to confer susceptibility to Type 1A diabetes in a recessive effects model [odds ratio for se2/se2, 1.68 (95% CI 1.20-2.35); corrected P value = 0.0075].
  
  
  
  The FUT2 gene contributed to the development of Type 1 diabetes in the present cohort of Japanese children.
authors.affiliation: Department of Paediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.|Department of Paediatrics, Oita University School of Medicine, Yufu, Japan.
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authors.lastname: Ihara
authors.affiliation: Department of Paediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: C
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authors.lastname: Fukano
authors.affiliation: Department of Molecular Endocrinology, National Research Institute for Child Health and Development, Tokyo, Japan.
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authors.lastname: Ayabe
authors.affiliation: Department of Molecular Endocrinology, National Research Institute for Child Health and Development, Tokyo, Japan.
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authors.affiliation: Department of Molecular Endocrinology, National Research Institute for Child Health and Development, Tokyo, Japan.|Department of Paediatrics, Hamamatsu University School of Medicine, Hamamatsu, Japan.
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authors.lastname: Ogata
authors.affiliation: Department of Paediatrics, Osaka City University Hospital, Osaka, Japan.
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authors.lastname: Kawamura
authors.affiliation: Department of Paediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan.
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authors.lastname: Urakami
authors.affiliation: Department of Paediatrics, Yokohama City Minato Red Cross Hospital, Yokohama, Japan.
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authors.lastname: Kikuchi
authors.affiliation: Department of Clinical Laboratory, Shikoku Medical Center for Children and Adults, Zentsuji, Japan.|Department of Paediatrics, Graduate School of Medical Sciences Tokushima University, Tokushima, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Yokota
authors.affiliation: Department of Paediatrics, Ehime University Hospital, Toon, Japan.|Department of Paediatrics, Sumitomo Besshi Hospital, Niihama, Japan.
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authors.lastname: Takemoto
authors.affiliation: Department of Paediatrics, Asahikawa Medical University Hospital, Asahikawa, Japan.|Department of Paediatrics, Asahikawa-Kosei General Hospital, Asahikawa, Japan.
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authors.lastname: Mukai
authors.affiliation: Department of Paediatrics, JR Sendai Hospital, Sendai, Japan.
authors.forename: A
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authors.affiliation: Department of Paediatrics, Saitama Medical University Hospital, Saitama, Japan.|Department of Paediatrics, Niigata University Medical and Dental Hospital, Niigata, Japan.
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authors.lastname: Kikuchi
authors.affiliation: Department of Paediatrics, Nagano Red Cross Hospital, Nagano, Japan.|Department of Paediatrics, Shinshu Ueda Medical Centre, Ueda, Japan.
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authors.affiliation: Department of Paediatrics, Dokkyo Medical University Hospital, Shimotsuga, Japan.
authors.forename: N
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authors.affiliation: Department of Paediatrics, Tokyo Dental College Ichikawa General Hospital, Ichikawa, Japan.
authors.forename: G
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authors.lastname: Sasaki
authors.affiliation: Department of Paediatrics, Yokosuka Kyosai Hospital, Yokosuka, Japan.
authors.forename: R
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authors.affiliation: Department of Pediatrics, Kitasato University Hospital, Sagamihara, Japan.|Department of Paediatrics and Adolescent Medicine, Juntendo University School of Medicine, Tokyo, Japan.
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authors.lastname: Takubo
authors.affiliation: Department of Paediatrics, St Marianna University School of Medicine, Kawasaki, Japan.
authors.forename: S
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authors.affiliation: Department of Paediatrics, National Mie Hospital, Tsu, Japan.
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authors.affiliation: Department of Paediatrics, Osaka Medical College, Takatsuki, Japan.
authors.forename: R
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authors.affiliation: Department of Paediatrics, Japanese Red Cross Kyoto Daiichi Hospital, Kyoto, Japan.
authors.forename: Z
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authors.lastname: Kizaki
authors.affiliation: Department of Paediatrics, Tottori University Faculty of Medicine, Yonago, Japan.
authors.forename: S
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authors.affiliation: Department of Paediatrics, Tottori Prefectural Kousei Hospital, Kurayoshi, Japan.
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authors.affiliation: Department of Paediatrics, Teine Keijinkai Hospital, Sapporo, Japan.|Department of Early Childhood Care and Education, Seitoku University Junior College, Matsudo, Japan.
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authors.lastname: Matsuura
authors.affiliation: Department of Paediatrics, Kanazawa University, Kanazawa, Japan.
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authors.affiliation: Department of Paediatrics, University Hospital, Kyoto Prefectural University of Medicine, Kyoto, Japan.
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authors.lastname: Kosaka
authors.affiliation: Takahashi Clinic, Kobe, Japan.
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authors.affiliation: Department of Paediatrics, Teikyo University Chiba Medical Center, Ichihara, Japan.
authors.forename: K
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authors.lastname: Minamitani
authors.affiliation: Matsuo Kodomo Clinic, Kyoto, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Matsuo
authors.affiliation: Department of Metabolism and Endocrinology, Saitama Children's Medical Centre, Saitama, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Mochizuki
authors.affiliation: Department of Paediatrics, University of Yamanashi Hospital, Chuo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Kobayashi
authors.affiliation: Miyanosawa Koike Child Clinic, Sapporo, Japan.
authors.forename: A
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authors.lastname: Koike
authors.affiliation: Division of Endocrinology and Metabolism, Department of Medical Subspecialties, National Medical Centre for Children and Mothers, Tokyo, Japan.
authors.forename: R
authors.initials: R
authors.lastname: Horikawa
authors.affiliation: Teno Clinic, Izumo, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Teno
authors.affiliation: Department of Paediatrics, Chuno Kosei Hospital, Seki, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Tsubouchi
authors.affiliation: Department of Paediatrics, Osaka City General Hospital, Osaka, Japan.|Department of Paediatrics, Osaka Police Hospital, Osaka, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Mochizuki
authors.affiliation: Igarashi Children's Clinic, Sendai, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Igarashi
authors.affiliation: Department of Paediatrics, Saitama Medical University Hospital, Saitama, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Amemiya
authors.affiliation: Department of Paediatrics, Tokyo Women's Medical University Medical Centre East, Tokyo, Japan.
authors.forename: S
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mesh_terms: D000017:ABO Blood-Group System / Q000235:genetics; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics*; D005647:Fucosyltransferases / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D007564:Japan; D000097631:Galactoside 2-alpha-L-fucosyltransferase
chemical_list: D000017:ABO Blood-Group System; D005647:Fucosyltransferases; D000097631:Galactoside 2-alpha-L-fucosyltransferase