title: Acute Effects of Near Infrared Light Therapy on Brain State in Healthy Subjects as Quantified by qEEG Measures.
abstract: OBJECTIVE
  Recent investigation suggests that near infrared (NIR) light may improve symptoms from mild traumatic brain injury. In addition, quantitative electroencephalography (qEEG) has shown measures correlating with concussion: P300, reaction time, and amplitude. The objective of this study was to determine whether NIR light treatment has an acute effect on brain state in healthy patients as measured by EEG.
  
  
  METHODS
  A total of 31 healthy volunteers, between the ages of 14 and 65, underwent qEEG event-related response tests before and after a 20-min NIR light head treatment. The treatment device is composed of 784 NIR GaAIAs LEDs covering 360 cm2on the head in a cap covering occipital, left temporal, right temporal frontal, and parietal lobes. The fluence rate was 1 J/cm2·min for a power density of 16.67 mW/cm2. Peak spectral wavelength at steady-state temperature (42.2°C) is 903 nm. The device delivered a total dose of 20 J/cm2. Two to four months later, 18 subjects returned for a second round of qEEG measurements, with a 20-min rest period in place of the NIR light treatment as a control arm.
  
  
  RESULTS
  Change in reaction time significantly differed between treated and control, with a mean of 23.8 msec improvement compared with controls (p = 0.035). Amplitude increased an average of 0.81 μV in treatment versus 0.22 μV in controls and did not reach significance. However, subanalysis of 14 treated subjects and 8 controls displaying initially low amplitude showed a mean increase in amplitude of 1.83 μV (30%) in treated subjects versus 0 μV in controls (p = 0.08). P300 measures did not show significant differences between groups.
  
  
  CONCLUSIONS
  The data suggest that NIR light may have an acute effect on reaction time and amplitude in certain subject subsets. There were no adverse events registered across the 31 subjects in the treatment group, nor in the 18 evaluable control group subjects.
authors.affiliation: 1 University of Colorado , Revolutionary MD, Denver, Colorado.
authors.forename: Fred
authors.initials: F
authors.lastname: Grover
authors.affiliation: 2 BioCare Systems, Inc. , Parker, Colorado.
authors.forename: Jon
authors.initials: J
authors.lastname: Weston
authors.affiliation: 3 BioCare Systems, Inc., Northwestern University , Evanston, Illinois.
authors.forename: Michael
authors.initials: M
authors.lastname: Weston
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001921:Brain / Q000528:radiation effects*; D001924:Brain Concussion / Q000628:therapy; D004569:Electroencephalography; D006801:Humans; D007259:Infrared Rays / Q000627:therapeutic use*; D008875:Middle Aged
keywords: LED light therapy; brain stimulation; concussion; light therapy; near infrared light; traumatic brain injury