title: Mean Daily Dosage of Aspirin and the Risk of Incident Alzheimer's Dementia in Patients with Type 2 Diabetes Mellitus: A Nationwide Retrospective Cohort Study in Taiwan.
abstract: Background. Type 2 diabetes mellitus patients are known to have higher risk of developing dementia while aspirin use has been shown to prevent incident dementia. This study was conducted to evaluate the potential benefits of aspirin use on dementia in patients with type 2 diabetes mellitus and identify the appropriate dosage of aspirin that provides the most benefit.Method. A Taiwan nationwide, population-based retrospective 8-year study was employed to analyze the association between the use of aspirin and incidence of dementia including Alzheimer's disease and non-Alzheimer's dementia using multivariate Cox-proportional hazards regression model and adjusting for several potential confounders.Results. Regular aspirin use in mean daily dosage of within 40 mg was associated with a decreased risk of developing incident Alzheimer's dementia in patients with type 2 diabetes mellitus (adjusted HR of 0.51 with 95% CI of 0.27-0.97,pvalue 0.041).Conclusion. A mean daily dosage of aspirin use within 40 mg might decrease the risk of developing Alzheimer's disease in patients with type 2 diabetes mellitus.
authors.affiliation: Department of Endocrinology and Metabolism, Tungs' Taichung MetroHarbor Hospital, Taichung 435, Taiwan; Department of Information Management, Hsing Wu University, New Taipei City, Taiwan.
authors.forename: Cheng-Wei
authors.identifier: 0000-0002-8103-4995
authors.initials: CW
authors.lastname: Chang
authors.affiliation: Department of Biomedical Informatics, Asia University, Taichung 413, Taiwan; Department of Computer Science and Information Engineering, National Central University, Chungli, Taiwan.
authors.forename: Jorng-Tzong
authors.initials: JT
authors.lastname: Horng
authors.affiliation: Department of Computer Science and Information Engineering, National Central University, Chungli, Taiwan.
authors.forename: Chi-Chang
authors.initials: CC
authors.lastname: Hsu
authors.affiliation: Department of Endocrinology and Metabolism, Tungs' Taichung MetroHarbor Hospital, Taichung 435, Taiwan; Department of Biomedical Informatics, Asia University, Taichung 413, Taiwan.
authors.forename: Jui-Ming
authors.identifier: 0000-0003-4198-4192
authors.initials: JM
authors.lastname: Chen
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000453:epidemiology* / Q000209:etiology / Q000517:prevention & control; D001241:Aspirin / Q000008:administration & dosage* / Q000627:therapeutic use; D016208:Databases, Factual; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D020011:Protective Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D012189:Retrospective Studies; D012306:Risk; D013624:Taiwan / Q000453:epidemiology
chemical_list: D020011:Protective Agents; D001241:Aspirin