title: Treating hepatocellular carcinoma with90Y-bearing microspheres: a review.
abstract: Hepatocellular carcinoma (HCC) is a disease usually diagnosed in its advanced-stage, and is frequently not amenable to curative surgical treatment. Also, HCC is resistant to chemotherapy and less vulnerable to radiation therapy compared to normal hepatic parenchyma. Both of these facts render the efficacy of adjuvant and palliative treatments problematic. Selective internal radiation therapy (SIRT) with90Y-bearing microspheres is characterized by preferentially delivering substantially high doses of radiation to a liver tumor dose simultaneously limiting the damage to its non-tumorous cells, providing an opportunity for effective local tumor control and even tumor regression therapy. The current article reviews the specific characters, dosimetry, possible applications, and special considerations toward the pre-existing radiation therapy of90Y microsphere SIRT in treating HCC.
authors.affiliation: Department of Nuclear Medicine and PET Center, China Medical University Hospital, No. 2, Yuh-Der Rd., North Dist., Taichung, 404, Taiwan.|Department of Biomedical Imaging and Radiological Science, China Medical University, 404, Taichung, Taiwan.
authors.forename: Te-Chun
authors.initials: TC
authors.lastname: Hsieh
authors.affiliation: Department of Nuclear Medicine, National Taiwan University Hospital Hsin-Chu Branch, Hsin-Chu Branch, No. 25, Ln. 442. Sec. 1, Jingguo Rd., East Dist.,, Hsinchu City, 300, Taiwan. kubler0514@gmail.com.
authors.forename: Yu-Chin
authors.initials: YC
authors.lastname: Wu
authors.affiliation: Department of Nuclear Medicine and PET Center, China Medical University Hospital, No. 2, Yuh-Der Rd., North Dist., Taichung, 404, Taiwan.|Department of Biomedical Imaging and Radiological Science, China Medical University, 404, Taichung, Taiwan.
authors.forename: Shung-Shung
authors.initials: SS
authors.lastname: Sun
authors.affiliation: Department of Nuclear Medicine and PET Center, China Medical University Hospital, No. 2, Yuh-Der Rd., North Dist., Taichung, 404, Taiwan.|Department of Biomedical Imaging and Radiological Science, China Medical University, 404, Taichung, Taiwan.
authors.forename: Kuo-Yang
authors.initials: KY
authors.lastname: Yen
authors.affiliation: Department of Nuclear Medicine and PET Center, China Medical University Hospital, No. 2, Yuh-Der Rd., North Dist., Taichung, 404, Taiwan. d10040@mail.cmuh.org.tw.|School of Medicine, China Medical University, 404, Taichung, Taiwan. d10040@mail.cmuh.org.tw.
authors.forename: Chia-Hung
authors.initials: CH
authors.lastname: Kao
keywords: 90Y microspheres; 99mTc macroaggregated albumin; External beam radiation therapy; Hepatocellular carcinoma; Radiation lobectomy; Selective internal radiation therapy; Transarterial chemoembolization