title: PATTERNS OF SENSITIZATION BY FOOD AND INHALANT COMPONENTS IN GEORGIAN PATIENTS.
abstract: Molecular-based allergy (MA) diagnostics is a novel approach used to map the allergen sensitization of a patient at a molecular level, using purified natural or recombinant allergen components instead of allergen extracts. The aim of our study was to: 1) investigate sensitization patterns to food and inhalant allergen components in different age groups of Georgian allergic patients 2) evaluate patient's potential risk of systemic reaction and manage dietary modifications. 3) Study food and inhalant components in different age groups in correlation with clinical manifestations of allergic disease. Allergic patient's sera samples were tested by ImmunoCap ISAC and specific IgE levels against 112 different allergen components were detected. The study population was comprising 81 allergic patients, included 26 adults (mean age 36.2±10.9) and 55 children (mean age 6.1±4.58). Results revealed that nGal d 1 (11.3%), nGal d 2 (10.1%) and nBos d 8 (10.1%) were more prevalent among food components. Cyn d 1 (35.4%), nCup a 1 (26.5%), n Amb a 1 (21.5%), rAlt a 1 (10.1%), rFel d1 (12.6%), rDer f 2 (26.50%), nDer p 2 (24%) were more prevalent among inhalant components. PR-10 reactivity was detected in 45%, Profilin - 43% and LTP - 29%. CRD food and inhalant pattern changes associated with age of children were correlating with the development of atopic march in Georgian population. Sensitization to most prevalent food components (Bos d 8 and Gal d 1) are predictors of allergy persistence in later life, in case of emergency individual action plan against anaphylaxis should be fulfilled.
authors.affiliation: Center of Allergy and Immunology; Tbilisi State Medical University, Georgia.
authors.forename: N
authors.initials: N
authors.lastname: Lomidze
authors.affiliation: Center of Allergy and Immunology; Tbilisi State Medical University, Georgia.
authors.forename: M
authors.initials: M
authors.lastname: Gotua
mesh_terms: D000328:Adult; D000485:Allergens / Q000032:analysis / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D005504:Food Analysis; D005512:Food Hypersensitivity / Q000276:immunology / Q000503:physiopathology*; D005846:Georgia (Republic); D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D001239:Inhalation; D011058:Pollen / Q000737:chemistry / Q000276:immunology*; D018570:Risk Assessment
chemical_list: D000485:Allergens; D007073:Immunoglobulin E