title: MCM7 polymorphisms associated with the AML relapse and overall survival.
abstract: The minichromosome maintenance complex component 7 (MCM7) encodes a member of MCM complex, which plays a critical role in the initiation of gene replication. Due to the importance of MCM complex, MCM7 gene has been regarded as a candidate gene for cancer development. In the present study, seven MCM7 polymorphisms were genotyped in 344 subjects composed of 103 acute myeloid leukemia (AML) patients and 241 normal controls to examine the possible associations between MCM7 polymorphisms and the risk of AML. MCM7 polymorphisms were not associated with the risk of AML (P > 0.05). However, MCM7 polymorphisms were significantly related to the relapse of AML and overall survival. The rs2070215 (N144S) showed a protective effect to the risk of AML relapse (OR = 0.37; Pcorr= 0.02). In haplotype analyses, the ht1 and ht2 showed significant associations with the risk of AML relapse (Pcorr= 0.02-0.03). In addition, rs1534309 showed an association with the overall survival of AML patients. Patients with major homozygote genotype (CC) of rs1534309 showed a higher survival rate than the patients with other genotypes (CG and GG). The results of the present study indicate that MCM7 polymorphisms may be able to predict the prognosis of AML patients.
authors.affiliation: Research Institute for Basic Science, Sogang University, Seoul, 121-742, Republic of Korea.|Department of Life Science, Sogang University, Seoul, 121-742, Republic of Korea.
authors.forename: Jin Sol
authors.initials: JS
authors.lastname: Lee
authors.affiliation: Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea.|Department of Genetic Epidemiology, SNP Genetics Inc., Seoul, South Korea.
authors.forename: Hyun Sub
authors.initials: HS
authors.lastname: Cheong
authors.affiliation: Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, 101 Daehang-ro, Jongno-gu, Seoul, 110-744, South Korea.
authors.forename: Youngil
authors.initials: Y
authors.lastname: Koh
authors.affiliation: Functional Genome Institute, PDXen Biosystem Inc., Seoul, South Korea.
authors.forename: Kwang-Sung
authors.initials: KS
authors.lastname: Ahn
authors.affiliation: Department of Life Science, Sogang University, Seoul, 121-742, Republic of Korea.|Department of Genetic Epidemiology, SNP Genetics Inc., Seoul, South Korea.
authors.forename: Hyoung Doo
authors.initials: HD
authors.lastname: Shin
authors.affiliation: Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea. ssysmc@snu.ac.kr.|Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, 101 Daehang-ro, Jongno-gu, Seoul, 110-744, South Korea. ssysmc@snu.ac.kr.|Clinical Research Institute, Seoul National University Hospital, Seoul, South Korea. ssysmc@snu.ac.kr.
authors.forename: Sung-Soo
authors.initials: SS
authors.lastname: Yoon
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis / Q000235:genetics* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D064168:Minichromosome Maintenance Complex Component 7 / Q000235:genetics*; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000235:genetics* / Q000401:mortality; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D015996:Survival Rate / Q000639:trends; D055815:Young Adult
chemical_list: C101624:MCM7 protein, human; D064168:Minichromosome Maintenance Complex Component 7
keywords: AML; MCM7; Overall survival; Relapse; SNP