title: Association of PTP1B with Outcomes of Breast Cancer Patients Who Underwent Neoadjuvant Chemotherapy.
abstract: PTP1B is involved in the oncogenesis of breast cancer. In addition, neoadjuvant therapy has been widely used in breast cancer; thus, a measurement to assess survival improvement could be pathological complete response (pCR). Our objective was to associate PTP1B overexpression with outcomes of breast cancer patients who underwent neoadjuvant chemotherapy. Forty-six specimens were included. Diagnostic biopsies were immunostained using anti-PTP1B antibody. Expression was categorized as negative (<5%) and overexpression (≥5%). Patients' responses were graded according to the Miller-Payne system. Sixty-three percent of patients overexpressed PTP1B. There was no significant association between PTP1B overexpression and pCR (P= 0.2). However, when associated with intrinsic subtypes, overexpression was higher in human epidermal growth factor receptor 2-positive-enriched specimens (P= 0.02). Ten-year progression-free survival showed no differences. Our preliminary results do not show an association between PTP1B over-expression and pCR; however, given the limited sample and heterogeneous treatment in our cohort, this hypothesis cannot be excluded.
authors.affiliation: Postgraduate and Research Department, Medical Faculty, National Polytechnic Institute, Mexico City, Mexico.
authors.forename: Monica M
authors.initials: MM
authors.lastname: Rivera Franco
authors.affiliation: Hematology and Oncology Department, National Institute of Medical Science and Nutrition Salvador Zubiran, Mexico City, Mexico.
authors.forename: Eucario
authors.initials: E
authors.lastname: Leon Rodriguez
authors.affiliation: Antomical Pathology Deparment, National Institute of Medical Science and Nutrition Salvador Zubiran, Mexico City, Mexico.
authors.forename: Braulio
authors.initials: B
authors.lastname: Martinez Benitez
authors.affiliation: Endocrinology Department, National Institute of Medical Science and Nutrition Salvador Zubiran, Mexico City, Mexico.
authors.forename: Luisa G
authors.initials: LG
authors.lastname: Villanueva Rodriguez
authors.affiliation: Postgraduate and Research Department, Medical Faculty, National Polytechnic Institute, Mexico City, Mexico.
authors.forename: Maria
authors.initials: M
authors.lastname: de la Luz Sevilla Gonzalez
authors.affiliation: Hematology and Oncology Department, National Institute of Medical Science and Nutrition Salvador Zubiran, Mexico City, Mexico.
authors.forename: Alejandra
authors.initials: A
authors.lastname: Armengol Alonso
keywords: PTP1B protein; breast cancer; neoadjuvant therapy