title: Relationship between the LHPP Gene Polymorphism and Resting-State Brain Activity in Major Depressive Disorder.
abstract: A single-nucleotide polymorphism at the LHPP gene (rs35936514) has been reported in genome-wide association studies to be associated with major depressive disorder (MDD). However, the neural system effects of rs35936514 that mediate the association are unknown. The present work explores whether the LHPP rs35936514 polymorphism moderates brain regional activity in MDD. A total of 160 subjects were studied: a CC group homozygous for the C allele (23 individuals with MDD and 57 controls) and a T-carrier group carrying the high risk T allele (CT/TT genotypes; 22 MDD and 58 controls). All participants underwent resting-state functional magnetic resonance imaging (rs-fMRI) scanning. Brain activity was assessed using the amplitudes of low-frequency fluctuations (ALFF). MDD patients showed a significant increased ALFF in the left middle temporal gyrus and occipital cortex. The T-carrier group showed increased ALFF in the left superior temporal gyrus. Significant diagnosis × genotype interaction was noted in the bilateral lingual gyri, bilateral dorsal lateral prefrontal cortex (dlPFC), and left medial prefrontal cortex (mPFC) (P< 0.05, corrected). Results demonstrated that MDD patients with LHPP rs35936514 CT/TT genotype may influence the regional brain activity. These findings implicate the effects of the rs35936514 variation on the neural system in MDD.
authors.affiliation: Department of Radiology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.
authors.forename: Lingling
authors.initials: L
authors.lastname: Cui
authors.affiliation: State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China.
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Gong
authors.affiliation: Department of Psychiatry, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.
authors.forename: Yanqing
authors.initials: Y
authors.lastname: Tang
authors.affiliation: Department of Psychiatry, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.
authors.forename: Lingtao
authors.initials: L
authors.lastname: Kong
authors.affiliation: Department of Radiology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.
authors.forename: Miao
authors.initials: M
authors.lastname: Chang
authors.affiliation: Department of Radiology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.
authors.forename: Haiyang
authors.initials: H
authors.lastname: Geng
authors.affiliation: Department of Radiology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.
authors.forename: Ke
authors.identifier: 0000-0002-4207-330X
authors.initials: K
authors.lastname: Xu
authors.affiliation: Department of Radiology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China; Department of Psychiatry, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA; The Research Institute for Brain Functional Imaging, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.
authors.forename: Fei
authors.identifier: 0000-0002-5982-2303
authors.initials: F
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging* / Q000502:physiology; D003865:Major Depressive Disorder / Q000000981:diagnostic imaging* / Q000235:genetics*; D005260:Female; D055106:Genome-Wide Association Study / Q000379:methods; D006801:Humans; D043564:Inorganic Pyrophosphatase / Q000235:genetics*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D012146:Rest / Q000502:physiology; D055815:Young Adult
chemical_list: D043564:Inorganic Pyrophosphatase; C543154:phospholysine phosphohistidine inorganic pyrophosphate phosphatase, human