title: Resveratrol prevents endothelial progenitor cells from senescence and reduces the oxidative reaction via PPAR‑γ/HO‑1 pathways.
abstract: Increasing evidence suggests endothelial progenitor cells (EPCs) improve neovascularization and endothelium regeneration. Resveratrol (RSV) is a natural polyphenolic compound, which has been demonstrated to exert multiple protective effects on the cardiovascular system, including inhibition of platelet adhesion and aggregation, reduction of myocardial ischemia‑reperfusion injury, and suppression of neointimal hyperplasia of injured vascular tissue. The present study investigated the role of RSV on levels of oxidative stress and senescence of EPCs, and the effects of RSV on vascular‑promoting and/or vascular‑healing capacity of EPCs. It was demonstrated that EPCs could promote the repair of endothelium of the injured artery. RSV reduced the oxidative reaction of EPCs and inhibited EPC senescence, and these effects may occur via the peroxisome proliferator‑activated receptor‑γ/heme oxygenase‑1 signaling pathways.
authors.affiliation: Department of Cardiology, Biomedical Research (Therapy) Center, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310058, P.R. China.
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Shen
authors.affiliation: Department of Cardiology, Biomedical Research (Therapy) Center, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310058, P.R. China.
authors.forename: Meihui
authors.initials: M
authors.lastname: Wang
authors.affiliation: Department of Cardiology, Biomedical Research (Therapy) Center, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310058, P.R. China.
authors.forename: Xukun
authors.initials: X
authors.lastname: Bi
authors.affiliation: Department of Cardiology, Biomedical Research (Therapy) Center, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310058, P.R. China.
authors.forename: Jiefang
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Cardiology, Biomedical Research (Therapy) Center, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310058, P.R. China.
authors.forename: Shaoxiang
authors.initials: S
authors.lastname: Wen
authors.affiliation: Department of Cardiology, Biomedical Research (Therapy) Center, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310058, P.R. China.
authors.forename: Guosheng
authors.initials: G
authors.lastname: Fu
authors.affiliation: Department of Cardiology, Biomedical Research (Therapy) Center, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310058, P.R. China.
authors.forename: Liang
authors.initials: L
authors.lastname: Xia
mesh_terms: D000328:Adult; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002478:Cells, Cultured; D016922:Cellular Senescence; D066026:Endothelial Progenitor Cells / Q000187:drug effects* / Q000378:metabolism*; D005260:Female; D015870:Gene Expression; D051547:Heme Oxygenase-1 / Q000378:metabolism*; D006801:Humans; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects*; D047495:PPAR gamma / Q000378:metabolism*; D011817:Rabbits; D017382:Reactive Oxygen Species / Q000378:metabolism; D000077185:Resveratrol; D015398:Signal Transduction / Q000187:drug effects; D013267:Stilbenes / Q000494:pharmacology*; D019098:Telomerase / Q000235:genetics / Q000378:metabolism
chemical_list: D000975:Antioxidants; D047495:PPAR gamma; D017382:Reactive Oxygen Species; D013267:Stilbenes; D009569:Nitric Oxide; D051547:Heme Oxygenase-1; C509186:TERT protein, human; D019098:Telomerase; D000077185:Resveratrol