title: The full genome sequences of 8 equine herpesvirus type 4 isolates from horses in Japan.
abstract: Equine herpesvirus type 4 (EHV-4) is one of the most important pathogens in horses. To clarify the key genes of the EHV-4 genome that cause abortion in female horses, we determined the whole genome sequences of a laboratory strain and 7 Japanese EHV-4 isolates that were isolated from 2 aborted fetuses and nasal swabs of 5 horses with respiratory disease. The full genome sequences and predicted amino acid sequences of each gene of these isolates were compared with of the reference EHV-4 strain NS80567 and Australian isolates that were reported in 2015. The EHV-4 isolates clustered in 2 groups which did not reflect their pathogenicity. A comparison of the predicted amino acid sequences of the genes did not reveal any genes that were associated with EHV-4-induced abortion.
authors.affiliation: Department of Applied Veterinary Sciences, United Graduate School of Veterinary Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.
authors.forename: Satoko
authors.initials: S
authors.lastname: Izume
authors.forename: Rikio
authors.initials: R
authors.lastname: Kirisawa
authors.forename: Kenji
authors.initials: K
authors.lastname: Ohya
authors.forename: Aiko
authors.initials: A
authors.lastname: Ohnuma
authors.forename: Takashi
authors.initials: T
authors.lastname: Kimura
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Omatsu
authors.forename: Yukie
authors.initials: Y
authors.lastname: Katayama
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Mizutani
authors.forename: Hideto
authors.initials: H
authors.lastname: Fukushi
mesh_terms: D000818:Animals; D005260:Female; D016679:Genome, Viral / Q000235:genetics*; D006566:Herpesviridae Infections / Q000453:epidemiology / Q000662:veterinary* / Q000821:virology; D023141:Herpesvirus 4, Equid / Q000235:genetics* / Q000302:isolation & purification; D006734:Horse Diseases / Q000453:epidemiology / Q000821:virology*; D006736:Horses / Q000821:virology; D007564:Japan / Q000453:epidemiology; D017422:Sequence Analysis, DNA / Q000662:veterinary