title: Comparison of Optical Coherence Tomography Angiography and Fluorescein Angiography for the Identification of Retinal Vascular Changes in Eyes With Diabetic Macular Edema.
abstract: To compare the visualization of microaneurysms (MA) and the foveal avascular zone (FAZ) area using optical coherence tomography angiography (OCTA) versus fluorescein angiography (FA) in patients with diabetic macular edema (DME).
  
  
  
  Patients were prospectively recruited for same-day imaging on spectral-domain OCTA and FA. OCTA images were automatically segmented into superficial (sOCTA) and deep (dOCTA) capillary plexuses. The number of visible MAs and the FAZ area were compared between the two imaging modalities.
  
  
  
  Nineteen eyes of 10 patients were included. There was a statistically significant difference between MA counts for FA, sOCTA, and dOCTA (P = .002), and median MA counts were 14.5 (range: 2-43), 9.75 (range: 0-37.5), and 22.5 (range: 5.5-46.5), respectively. dOCTA showed significantly more MAs than sOCTA (P < .001). Although not significant statistically, dOCTA revealed more MAs than FA (P = .06). There was a statistically significant difference between FAZ area for FA, sOCTA, and dOCTA (P = .046), and median FAZ areas were 0.444 (range: 0.1-0.689), 0.224 (range: 0.335-0.806), and 0.345 (range: 0.106-0.881), respectively. FA showed a significantly larger FAZ area than sOCTA (P = .04).
  
  
  
  Deep plexus OCTA can better identify microaneurysms compared to either sOCTA or FA. The FAZ area appears larger on FA in contrast to OCTA of both plexuses. [Ophthalmic Surg Lasers Imaging Retina. 2016;47:1013-1019.].
authors.forename: Murilo Bertazzo
authors.initials: MB
authors.lastname: Peres
authors.forename: Renata Tiemi
authors.initials: RT
authors.lastname: Kato
authors.forename: Vinicius F
authors.initials: VF
authors.lastname: Kniggendorf
authors.forename: Emily D
authors.initials: ED
authors.lastname: Cole
authors.forename: Sumru
authors.initials: S
authors.lastname: Onal
authors.forename: Elmar
authors.initials: E
authors.lastname: Torres
authors.forename: Ricardo
authors.initials: R
authors.lastname: Louzada
authors.forename: Rubens
authors.initials: R
authors.lastname: Belfort
authors.forename: Jay S
authors.initials: JS
authors.lastname: Duker
authors.forename: Eduardo A
authors.initials: EA
authors.lastname: Novais
authors.forename: Caio V
authors.initials: CV
authors.lastname: Regatieri
mesh_terms: D000368:Aged; D003430:Cross-Sectional Studies; D003930:Diabetic Retinopathy / Q000000981:diagnostic imaging*; D005260:Female; D005451:Fluorescein Angiography; D005584:Fovea Centralis / Q000098:blood supply*; D006801:Humans; D008266:Macula Lutea / Q000503:physiopathology; D008269:Macular Edema / Q000000981:diagnostic imaging*; D008297:Male; D000071071:Microaneurysm / Q000000981:diagnostic imaging; D008875:Middle Aged; D011446:Prospective Studies; D012171:Retinal Vessels / Q000000981:diagnostic imaging / Q000473:pathology; D041623:Tomography, Optical Coherence / Q000379:methods*; D014792:Visual Acuity