title: Nanofibers containing tetracycline/β-cyclodextrin: Physico-chemical characterization and antimicrobial evaluation.
abstract: This study aimed to compare two nanofiber drug delivery systems that were prepared with an electrospun process and have the potential to serve as adjuvants for the treatment of periodontal disease. The first system was composed of polycaprolactone loaded with tetracycline (TCN) and the second was composed of polycaprolactone loaded with tetracycline/β-cyclodextrin (TCN:BCD). An antimicrobial diffusion test was performed for each of these sets of nanofibers with the microorganisms, Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis, both of which contribute to periodontal disease. In vitro release profiles were also obtained, and the nanofibers were characterized by thermal analysis, x-ray powder diffraction, infrared absorption spectroscopy, and scanning electron microscopy. Profiles of the TCN and TCN:BCD nanofibers showed that drug release occurred for up to 14days. However, the TCN:BCD nanofibers appeared to better protect and enhance the biological absorption of TCN due to the formation of a TCN:BCD inclusion complex.
authors.affiliation: Chemistry Department, Universidade Federal de Minas Gerais, Av. Presidente Antônio Carlos 6627, Belo Horizonte, MG, CEP 31270-901, Brazil.
authors.forename: Ana P F
authors.initials: AP
authors.lastname: Monteiro
authors.affiliation: Restorative Dentistry Department, Faculty of Dentistry, Universidade Federal de Minas Gerais, Av. Presidente Antônio Carlos 6627, Belo Horizonte, MG, CEP 31270-901, Brazil.
authors.forename: Cíntia M S L
authors.initials: CM
authors.lastname: Rocha
authors.affiliation: Chemistry Department, Universidade Federal de Minas Gerais, Av. Presidente Antônio Carlos 6627, Belo Horizonte, MG, CEP 31270-901, Brazil.
authors.forename: Michele F
authors.initials: MF
authors.lastname: Oliveira
authors.affiliation: Restorative Dentistry Department, Faculty of Dentistry, Universidade Federal de Minas Gerais, Av. Presidente Antônio Carlos 6627, Belo Horizonte, MG, CEP 31270-901, Brazil.
authors.forename: Sávio M L
authors.initials: SM
authors.lastname: Gontijo
authors.affiliation: Chemistry Department, Universidade Federal de Minas Gerais, Av. Presidente Antônio Carlos 6627, Belo Horizonte, MG, CEP 31270-901, Brazil.
authors.forename: Ricardo R
authors.initials: RR
authors.lastname: Agudelo
authors.affiliation: Chemistry Department, Universidade Federal de Minas Gerais, Av. Presidente Antônio Carlos 6627, Belo Horizonte, MG, CEP 31270-901, Brazil.
authors.forename: Rubén D
authors.initials: RD
authors.lastname: Sinisterra
authors.affiliation: Restorative Dentistry Department, Faculty of Dentistry, Universidade Federal de Minas Gerais, Av. Presidente Antônio Carlos 6627, Belo Horizonte, MG, CEP 31270-901, Brazil. Electronic address: mecortes@yahoo.com.
authors.forename: Maria E
authors.initials: ME
authors.lastname: Cortés
mesh_terms: D064206:Aggregatibacter / Q000187:drug effects*; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D057139:Nanofibers / Q000737:chemistry*; D017861:Porphyromonas / Q000187:drug effects*; D013752:Tetracycline / Q000737:chemistry* / Q000494:pharmacology*; D047392:beta-Cyclodextrins / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000890:Anti-Infective Agents; D047392:beta-Cyclodextrins; D013752:Tetracycline
keywords: Antimicrobial activity; Cyclodextrin; Electrospun; Inclusion compound; Nanofibers; Tetracycline