title: SNAP23 promotes the malignant process of ovarian cancer.
abstract: BACKGROUND
  Ovarian cancer (OC) was the primary malignant gynecological cancer and SNARE protein is closely related with tumor progression. Here, we identified SNAP23, a member of SNARE complex, as a potential oncogene in OC.
  
  
  METHODS
  We determined the expression of SNAP23 in OC tissues and explored the clinical significance through bioinformatics analysis. The effects of SNAP23 on OC cell proliferation, migration, invasion, cell cycle and apoptosis were then evaluated in vitro.
  
  
  RESULTS
  SNAP23 is hyper-expressed in OC tumor tissues compared to normal tissues, and increased expression of SNAP23 is associated with a poor progression free survival (HR = 1.24, 95% CI = 1.07-1.44, p = 0.0042). SNAP23 knock down increases cell apoptosis and inhibits cell proliferation, migration and invasion of OC cells. GO analysis reveals that most genes correlated highly with SNAP23 were enriched in metabolic process.
  
  
  CONCLUSIONS
  Our data suggest that SNAP23 may serve as an oncogene promoting tumorigenicity of OC cells by decreasing apoptotic process.
authors.affiliation: Department of Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Cancer Institute of Jiangsu Province, Nanjing, Jiangsu, China, 210009.|Department of Cardiothoracic Surgery, Jinling Hospital, Southern Medical University, East Zhongshan Road 305, Xuanwu District, Nanjing, Jiangsu, 210002, People's Republic of China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Sun
authors.affiliation: Department of Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Cancer Institute of Jiangsu Province, Nanjing, Jiangsu, China, 210009.|Department of Pathology, Jiangsu Cancer Hospital, Baiziting 42, Nanjing, 210009, People's Republic of China.
authors.forename: Xing
authors.initials: X
authors.lastname: Huang
authors.affiliation: Department of Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Cancer Institute of Jiangsu Province, Nanjing, Jiangsu, China, 210009.|Department of Gynecologic oncology, Jiangsu Cancer Hospital, Baiziting 42, Nanjing, 210009, People's Republic of China.
authors.forename: Quanli
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Department of Gynecologic oncology, Jiangsu Cancer Hospital, Baiziting 42, Nanjing, 210009, People's Republic of China.
authors.forename: Junwei
authors.initials: J
authors.lastname: Qu
authors.affiliation: Department of Gynecologic oncology, Jiangsu Cancer Hospital, Baiziting 42, Nanjing, 210009, People's Republic of China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Shen
authors.affiliation: Department of Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Cancer Institute of Jiangsu Province, Nanjing, Jiangsu, China, 210009.|Department of Thoracic Surgery, Jiangsu Cancer Hospital, Baiziting 42, Nanjing, 210009, People's Republic of China.
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Cancer Institute of Jiangsu Province, Nanjing, Jiangsu, China, 210009.|Department of Thoracic Surgery, Jiangsu Cancer Hospital, Baiziting 42, Nanjing, 210009, People's Republic of China.
authors.forename: Haijun
authors.initials: H
authors.lastname: Sun
authors.affiliation: Department of Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Cancer Institute of Jiangsu Province, Nanjing, Jiangsu, China, 210009.|Department of Thoracic Surgery, Jiangsu Cancer Hospital, Baiziting 42, Nanjing, 210009, People's Republic of China.
authors.forename: Jie
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Cancer Institute of Jiangsu Province, Nanjing, Jiangsu, China, 210009. xulin83cn@outlook.com.|Department of Thoracic Surgery, Jiangsu Cancer Hospital, Baiziting 42, Nanjing, 210009, People's Republic of China. xulin83cn@outlook.com.
authors.forename: Lin
authors.initials: L
authors.lastname: Xu
authors.affiliation: Department of Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Cancer Institute of Jiangsu Province, Nanjing, Jiangsu, China, 210009. cxxxxcyd@163.com.|Department of Gynecologic oncology, Jiangsu Cancer Hospital, Baiziting 42, Nanjing, 210009, People's Republic of China. cxxxxcyd@163.com.
authors.forename: Xiaoxiang
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Cancer Institute of Jiangsu Province, Nanjing, Jiangsu, China, 210009. Robbishren@163.com.|Department of Thoracic Surgery, Jiangsu Cancer Hospital, Baiziting 42, Nanjing, 210009, People's Republic of China. Robbishren@163.com.
authors.forename: Binhui
authors.initials: B
authors.lastname: Ren
mesh_terms: D045744:Cell Line, Tumor; D002465:Cell Movement; D049109:Cell Proliferation; D018450:Disease Progression; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009361:Neoplasm Invasiveness; D010051:Ovarian Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D011379:Prognosis; D050766:Qb-SNARE Proteins / Q000235:genetics* / Q000378:metabolism*; D050767:Qc-SNARE Proteins / Q000235:genetics* / Q000378:metabolism*; D015854:Up-Regulation
chemical_list: D050766:Qb-SNARE Proteins; D050767:Qc-SNARE Proteins; C100493:SNAP23 protein, human
keywords: Apoptosis; Ovarian cancer; SNAP23; SNARE