title: Prevalence and severity by age and other clinical correlates of haemophilic arthropathy of the elbow, knee and ankle among Taiwanese patients with haemophilia.
abstract: OBJECTIVE
  Haemophilic arthropathy (HA) is a major complication in patients with haemophilia (PWH), but the study of age-specific prevalence and severity of HA is very limited in Asian countries.
  
  
  METHODS
  This study retrospectively reviewed 146 severe- and moderate-type Taiwanese PWH aged 4-73 years, with roentgenograms of elbows, knees and ankles and calculated Pettersson scores.
  
  
  RESULTS
  The prevalence of HA, mean number of HAs per patient and mean Pettersson scores of all the joints were 42.8%, 1.3 and 1.9 points in PWH aged 4-10 years; 64.3%, 1.4 and 4.1 points in PWH aged 11-19 years; 97.1%, 2.9 and 15.6 points in PWH aged 20-29 years; 93.1%, 4.4 and 33.1 points in PWH aged 30-39 years; 100%, 5.1 and 46.1 points in PWH aged 40-49 years and 100%, 5 and 49.6 points in PWH aged ≥50 years, respectively. There was a high prevalence of HA for PWH aged ≥20 years. Among PWH aged <20 years, prevalence of HA was low and mild ankle arthropathy was the most common. Besides, in the four age groups aged <40 years, the prevalence of ankle arthropathy was the highest, followed by elbow arthropathy and then knee arthropathy.
  
  
  CONCLUSIONS
  Although severe arthropathy of the six major joints was rare in PWH aged <30 years, it increased rapidly in PWH after 30 years. Analysis of clinical correlates suggested that age, severity of haemophilia, absence of prophylaxis and presence of HCV infection correlated positively with Pettersson scores.
authors.affiliation: Graduate Institute of Clinical Medicine, School of Medicine, Taipei Medical University, Taipei, Taiwan.|Division of Pediatric Hematology/Oncology, Taipei Medical University Hospital, Taipei, Taiwan.|Hemophilia Center, Taipei Medical University Hospital, Taipei, Taiwan.
authors.forename: C-Y
authors.initials: CY
authors.lastname: Chang
authors.affiliation: Department of Rehabilitation, Tri-Service General Hospital, Taipei, Taiwan.|Hemophilia Care and Research Center, Tri-Service General Hospital, Taipei, Taiwan.
authors.forename: T-Y
authors.initials: TY
authors.lastname: Li
authors.affiliation: Department of Pediatrics, Tungs' Taichung MetroHarbor Hospital, Taipei, Taiwan.|Department of Pediatrics, National Defense Medical Center, Taipei, Taiwan.
authors.forename: S-N
authors.initials: SN
authors.lastname: Cheng
authors.affiliation: Hemophilia Care and Research Center, Tri-Service General Hospital, Taipei, Taiwan.|Department of Orthopedics, Tri-Service General Hospital, Taipei, Taiwan.
authors.forename: R-Y
authors.initials: RY
authors.lastname: Pan
authors.affiliation: Hemophilia Center, Taipei Medical University Hospital, Taipei, Taiwan.|Department of Medical Imaging, Taipei Medical University Hospital, Taipei, Taiwan.
authors.forename: H-J
authors.initials: HJ
authors.lastname: Wang
authors.affiliation: Graduate Institute of Clinical Medicine, School of Medicine, Taipei Medical University, Taipei, Taiwan.|Hemophilia Center, Taipei Medical University Hospital, Taipei, Taiwan.|Department of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan.
authors.forename: S-Y
authors.initials: SY
authors.lastname: Lin
authors.affiliation: Hemophilia Care and Research Center, Tri-Service General Hospital, Taipei, Taiwan.|Division of Hematology/Oncology, Department of Internal Medicine, National Defense Medical Center, Tri-Service General Hospital, Taipei, Taiwan.
authors.forename: Y-C
authors.initials: YC
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000843:Ankle Joint / Q000473:pathology*; D002648:Child; D004551:Elbow Joint / Q000473:pathology*; D005260:Female; D006395:Hemarthrosis / Q000453:epidemiology* / Q000209:etiology; D006467:Hemophilia A / Q000188:drug therapy*; D006801:Humans; D007719:Knee Joint / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D013624:Taiwan; D055815:Young Adult
keywords: Pettersson score; Taiwan; haemophilia; haemophilic arthropathy; prevalence; severity