title: Drug-Induced Liver Disease: Clinical Course.
abstract: Drug-induced liver injury (DILI) is a term used to describe a spectrum of clinical presentations and severity that ranges from mild elevation of liver enzymes on routine blood work to acute liver failure and death. Approximately 10% of all patients with DILI develop acute liver failure resulting in death or liver transplantation. DILI may be prolonged with persistence of elevated liver enzymes for longer than 6 months in approximately 5% to 20% of cases. Cirrhosis and long-term liver-related morbidity and mortality have also been described but are rare, occurring in 1% to 3% of cases.
authors.affiliation: Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh Medical Center, University of Pittsburgh School of Medicine, 200 Lothrop Street, Pittsburgh, PA 15213, USA.
authors.forename: Hemamala
authors.initials: H
authors.lastname: Saithanyamurthi
authors.affiliation: Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh Medical Center, University of Pittsburgh School of Medicine, 200 Lothrop Street, Pittsburgh, PA 15213, USA. Electronic address: jazwinskiab@upmc.edu.
authors.forename: Alison Jazwinski
authors.initials: AJ
authors.lastname: Faust
mesh_terms: D056486:Chemical and Drug Induced Liver Injury / Q000453:epidemiology* / Q000209:etiology / Q000628:therapy; D018450:Disease Progression; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D017114:Liver Failure, Acute / Q000453:epidemiology* / Q000209:etiology / Q000628:therapy; D008111:Liver Function Tests; D016031:Liver Transplantation / Q000379:methods; D008297:Male; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D011379:Prognosis; D018570:Risk Assessment; D012720:Severity of Illness Index; D016019:Survival Analysis; D028761:Withholding Treatment
chemical_list: D004364:Pharmaceutical Preparations
keywords: Acute liver failure; Chronic drug-induced liver injury; Drug-induced liver injury