title: Retrospective analysis of laser vs other therapeutic modalities for laryngeal papillomatosis: European multicenter study.
abstract: Laryngeal papillomatosis can be an aggressive and potentially life-threatening disease, affecting both children and adults. Local excision is the gold standard of treatment, but recurrences are frequently inevitable. The purpose of this study was to present the experience of three institutions with different therapeutic modalities and discuss them in relation with the relevant literature.
  
  
  
  Sixty patients underwent papilloma resection during the last decade in three institutions (Homburg/Saar and Marburg, Germany and Athens,Greece). Patient data were retrospectively analyzed for therapeutic modalities applied, rate of complications and synechia formation, necessary operations and need for tracheostomy.
  
  
  
  Carbon dioxide laser therapy was the most common modality applied alone or combined with other treatment modalities. No major complication was observed, while glottic synechia was the most common minor complication in 5 (8.3%) patients. Of the patient cohort 55.6% required reoperation, while no patient required tracheostomy.
  
  
  
  Surgical debulking with or without adjuvant treatment remains the mainstay of treatment, which mainly aims to reduce the number and frequency of recurrences since no definitive curative therapy is known so far.
authors.affiliation: Department of Otorhinolaryngology, University Medical Centre Homburg/Saar, Homburg, Germany.
authors.forename: Giorgos
authors.initials: G
authors.lastname: Papaspyrou
authors.forename: Bernhard
authors.initials: B
authors.lastname: Schick
authors.forename: Spyros
authors.initials: S
authors.lastname: Papaspyrou
authors.forename: Behfar
authors.initials: B
authors.lastname: Eivazi
authors.forename: Basel
authors.initials: B
authors.lastname: Al Kadah
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000890:Anti-Infective Agents / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery*; D007828:Laryngoscopy; D053685:Laser Therapy / Q000009:adverse effects / Q000295:instrumentation; D054020:Lasers, Gas; D008297:Male; D008875:Middle Aged; D010212:Papilloma / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery*; D053918:Papillomavirus Vaccines / Q000627:therapeutic use; D010778:Photochemotherapy; D011183:Postoperative Complications / Q000209:etiology / Q000601:surgery; D012008:Recurrence; D012086:Reoperation; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000890:Anti-Infective Agents; D053918:Papillomavirus Vaccines