title: Biomarkers and Genetics in Peripheral Artery Disease.
abstract: BACKGROUND
  Peripheral artery disease (PAD) is highly prevalent and there is considerable diversity in the initial clinical manifestation and disease progression among individuals. Currently, there is no ideal biomarker to screen for PAD, to risk stratify patients with PAD, or to monitor therapeutic response to revascularization procedures. Advances in human genetics have markedly enhanced the ability to develop novel diagnostic and therapeutic approaches across a host of human diseases, but such developments in the field of PAD are lagging.
  
  
  BACKGROUND
  In this article, we will discuss the epidemiology, traditional risk factors for, and clinical presentations of PAD. We will discuss the possible role of genetic factors and gene-environment interactions in the development and/or progression of PAD. We will further explore future avenues through which genetic advances can be used to better our understanding of the pathophysiology of PAD and potentially find newer therapeutic targets. We will discuss the potential role of biomarkers in identifying patients at risk for PAD and for risk stratifying patients with PAD, and novel approaches to identification of reliable biomarkers in PAD.
  
  
  CONCLUSIONS
  The exponential growth of genetic tools and newer technologies provides opportunities to investigate and identify newer pathways in the development and progression of PAD, and thereby in the identification of newer biomarkers and therapies.
authors.affiliation: Division of Cardiovascular Medicine and Robert Bernie Cardiovascular Research Center, University of Virginia, Charlottesville, VA.
authors.forename: Surovi
authors.initials: S
authors.lastname: Hazarika
authors.affiliation: Division of Cardiovascular Medicine and Robert Bernie Cardiovascular Research Center, University of Virginia, Charlottesville, VA. bha4n@hscmail.mcc.virginia.edu.
authors.forename: Brian H
authors.initials: BH
authors.lastname: Annex
mesh_terms: D015415:Biomarkers / Q000032:analysis*; D006801:Humans; D058729:Peripheral Arterial Disease / Q000188:drug therapy / Q000453:epidemiology / Q000235:genetics*; D012307:Risk Factors
chemical_list: D015415:Biomarkers