title: [Is CAPRA-S score a valid tool in our environment to predict biochemical recurrence, metastasis and death after radical prostatectomy?]
abstract: OBJECTIVE
  To perform an external validation of CAPRA-S Score to determine prediction of biochemical recurrence, metastasis and death by PCa after RP in Argentinian population.
  
  
  METHODS
  216 patients were studied. The probability of the score to predict biochemical recurrence after RP was analyzed by the Cox proportional method. Biochemical recurrence, metastasis and cancer specific free survivals were determined by Kaplan method. The accuracy of CAPRA-S score to predict biochemical recurrence, metastasis and death by PCa was made in accordance with Harrells concordance index.
  
  
  RESULTS
  Median follow up was 74 months. Biochemical recurrence index increased proportionally with the increment of CAPRA-S score. In the stratification of patients in low, intermediate or high risk, biochemical recurrence free rates were 85%, 54% and 4% respectively. Concordance index (C-Index) for biochemical progression, metastasis and death by PCa were 0.85, 0.90 and 0.90 respectively.
  
  
  CONCLUSIONS
  CAPRA-S score is an easily applicable tool and has high predictive accuracy to determine biochemical recurrence, metastasis and death by PCa probabilities in our population. Concordance Index in these variables was higher than 0.85.
authors.affiliation: Centro Urológico Profesor Bengió. Córdoba. Argentina.
authors.forename: Rubén G
authors.initials: RG
authors.lastname: Bengió
authors.affiliation: Centro Urológico Profesor Bengió. Córdoba. Argentina.
authors.forename: Leandro
authors.initials: L
authors.lastname: Arribillaga
authors.affiliation: Centro Urológico Profesor Bengió. Córdoba. Argentina.
authors.forename: Verónica
authors.initials: V
authors.lastname: Bengió
authors.affiliation: Centro Urológico Profesor Bengió. Córdoba. Argentina.
authors.forename: Ariel
authors.initials: A
authors.lastname: Montedoro
authors.affiliation: Centro Urológico Profesor Bengió. Córdoba. Argentina.
authors.forename: H
authors.initials: H
authors.lastname: García Önto
authors.affiliation: Centro Urológico Profesor Bengió. Córdoba. Argentina.
authors.forename: Javier
authors.initials: J
authors.lastname: Epelde
authors.affiliation: Centro Urológico Profesor Bengió. Córdoba. Argentina.
authors.forename: Esteban
authors.initials: E
authors.lastname: Cordero
authors.affiliation: Centro Urológico Profesor Bengió. Córdoba. Argentina.
authors.forename: Guillermo
authors.initials: G
authors.lastname: Oulton
authors.affiliation: Centro Urológico Profesor Bengió. Córdoba. Argentina.
authors.forename: Rubén H
authors.initials: RH
authors.lastname: Bengió
mesh_terms: D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local / Q000097:blood / Q000175:diagnosis; D011379:Prognosis; D017430:Prostate-Specific Antigen / Q000097:blood; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000097:blood / Q000401:mortality* / Q000473:pathology* / Q000601:surgery; D012189:Retrospective Studies
chemical_list: D017430:Prostate-Specific Antigen