title: Brachial-ankle pulse wave velocity and metabolic syndrome in general population: the APAC study.
abstract: Metabolic syndrome (MetS) is correlated with arterial stiffness and can be evaluated by brachial-ankle pulse wave velocity (baPWV). We investigated potential associations between MetS and baPWV in a Chinese community population.
  
  
  
  The community-based Asymptomatic Polyvascular Abnormalities in Community study examined asymptomatic polyvascular abnormalities in a Chinese population aged ≥40 years. The relationship between MetS and its components and baPWV was analyzed by multivariate logistic and linear regression models.
  
  
  
  Out of 5181 study participants, 1271 subjects (24.53%) had MetS. Mean values of baPWV in subjects with 0, 1, 2,3, 4, and 5 components of MetS were 1430, 1526, 1647, 1676,1740, and 1860 cm/s, respectively (p < 0.001 for trend). After adjusting for confounding risk factors, MetS was significantly associated with baPWV (odds ratio [OR]: 2.74; 95% CI: 2.28, 3.30). Among the five components of MetS, elevated blood pressure was the most important factor for baPWV. All models of multivariate linear regression analysis showed a significant positive correlation between the increasing numbers of MetS components and baPWV (p < 0.0001).
  
  
  
  baPWV was associated with MetS and was greater with increasing numbers of MetS components. Elevated blood pressure was the most important factor for baPWV.
authors.affiliation: Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, No. 6 Tiantanxili, Dongcheng District, Beijing, 100050, People's Republic of China.|China National Clinical Research Center for Neurological Diseases, Beijing, People's Republic of China.|Center of Stroke, Beijing Institute for Brain Disorders, Beijing, People's Republic of China.|Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, People's Republic of China.|Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, 100069, People's Republic of China.
authors.forename: Anxin
authors.initials: A
authors.lastname: Wang
authors.affiliation: Department of Epidemiology and Health Statistics, Academy of public health and management, Weifang Medical University, No. 7166 Baotongxijie, Weicheng District, Weifang, 261053, People's Republic of China.
authors.forename: Zhaoping
authors.initials: Z
authors.lastname: Su
authors.affiliation: Department of Cardiology, Tangshan People's Hospital, Tangshan, People's Republic of China.
authors.forename: Xiaoxue
authors.initials: X
authors.lastname: Liu
authors.affiliation: Graduate School, North China University of Science and Technology, Tangshan, People's Republic of China.
authors.forename: Yuling
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Cardiology, Kailuan Hospital, North China University of Science and Technology, No. 57 Xinhua Road, Lubei District, Tangshan, 063000, People's Republic of China.
authors.forename: Shuohua
authors.initials: S
authors.lastname: Chen
authors.affiliation: Department of Epidemiology and Health Statistics, Academy of public health and management, Weifang Medical University, No. 7166 Baotongxijie, Weicheng District, Weifang, 261053, People's Republic of China.
authors.forename: Suzhen
authors.initials: S
authors.lastname: Wang
authors.affiliation: Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, 100069, People's Republic of China.
authors.forename: Yanxia
authors.initials: Y
authors.lastname: Luo
authors.affiliation: Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, 100069, People's Republic of China. statguo@ccmu.edu.cn.
authors.forename: Xiuhua
authors.initials: X
authors.lastname: Guo
authors.affiliation: Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, No. 6 Tiantanxili, Dongcheng District, Beijing, 100050, People's Republic of China. zxq@vip.163.com.|China National Clinical Research Center for Neurological Diseases, Beijing, People's Republic of China. zxq@vip.163.com.|Center of Stroke, Beijing Institute for Brain Disorders, Beijing, People's Republic of China. zxq@vip.163.com.|Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, People's Republic of China. zxq@vip.163.com.
authors.forename: Xingquan
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Department of Cardiology, Kailuan Hospital, North China University of Science and Technology, No. 57 Xinhua Road, Lubei District, Tangshan, 063000, People's Republic of China. drwusl@163.com.
authors.forename: Shouling
authors.initials: S
authors.lastname: Wu
mesh_terms: D000328:Adult; D000368:Aged; D055109:Ankle Brachial Index; D058070:Asymptomatic Diseases; D050197:Atherosclerosis / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology*; D001794:Blood Pressure; D016009:Chi-Square Distribution; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology; D016014:Linear Models; D016015:Logistic Models; D008297:Male; D024821:Metabolic Syndrome / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology*; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012307:Risk Factors; D059289:Vascular Stiffness
keywords: Arterial stiffnes; Brachial-ankle pulse wave velocity; Cardio-cerebrovascular diseases; Metabolic syndrome