title: Circulating biomarkers of oxidative stress in chronic obstructive pulmonary disease: a systematic review.
abstract: Chronic obstructive pulmonary disease (COPD) is a progressive condition characterized by airflow limitation associated with an abnormal inflammatory response of the lungs to noxious particles and gases, caused primarily by cigarette smoking. Increased oxidative burden plays an important role in the pathogenesis of COPD. There is a delicate balance between the toxicity of oxidants and the protective function of the intracellular and extracellular antioxidant defense systems, which is critically important for the maintenance of normal pulmonary functions. Several biomarkers of oxidative stress are available and have been evaluated in COPD. In this review, we summarize the main literature findings about circulating oxidative stress biomarkers, grouped according to their method of detection, measured in COPD subjects.
authors.affiliation: Department of Respiratory Diseases, Azienda Ospedaliero Universitaria di Sassari, Sassari, Italy.
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Zinellu
authors.affiliation: Department of Biomedical Sciences, University of Sassari, Sassari, Italy.
authors.forename: Angelo
authors.initials: A
authors.lastname: Zinellu
authors.affiliation: Department of Respiratory Diseases, Azienda Ospedaliero Universitaria di Sassari, Sassari, Italy.
authors.forename: Alessandro Giuseppe
authors.initials: AG
authors.lastname: Fois
authors.affiliation: Quality Control Unit, University Hospital of Sassari (AOU SS); Department of Biomedical Sciences, University of Sassari, Sassari, Italy.
authors.forename: Ciriaco
authors.initials: C
authors.lastname: Carru
authors.affiliation: Department of Respiratory Diseases, Azienda Ospedaliero Universitaria di Sassari, Sassari, Italy. pirina@uniss.it.
authors.forename: Pietro
authors.identifier: 0000-0003-1457-8025
authors.initials: P
authors.lastname: Pirina
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood*; D000073888:Cell-Free Nucleic Acids / Q000097:blood; D004247:DNA / Q000097:blood; D004249:DNA Damage; D006801:Humans; D015227:Lipid Peroxidation; D008054:Lipid Peroxides / Q000097:blood; D018384:Oxidative Stress; D011237:Predictive Value of Tests; D011379:Prognosis; D050050:Protein Carbonylation; D029424:Pulmonary Disease, Chronic Obstructive / Q000097:blood* / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D017382:Reactive Oxygen Species / Q000097:blood; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects / Q000097:blood
chemical_list: D015415:Biomarkers; D000073888:Cell-Free Nucleic Acids; D008054:Lipid Peroxides; D017382:Reactive Oxygen Species; D004247:DNA
keywords: Biomarkers; Chronic obstructive pulmonary disease; Oxidative stress; Peripheral blood