title: Contributions of triggering-receptor-expressed-on-myeloid-cells-2 to neurological diseases.
abstract: Recent laboratory and gene sequencing data suggest that variations in receptors called the "triggering-receptors-expressed-on-myeloid-cells" (TREMs) are implicated in Alzheimer's disease, Parkinson's disease, multiple sclerosis, and frontotemporal lobar degeneration. TREM receptors are thought to play a critical role in regulating the immune system, inflammation, and certain cellular functions. One TREM, in particular, TREM2, is highly expressed on cells of the myeloid lineage. The binding of TREM2 to the adapter protein, DNAX activating protein of 12 kD (DAP12), in microglial cells has been shown to modulate phagocytosis within the nervous system. This review highlights the role of TREM2 in neurological diseases. Moreover, here we consider potential contributions of TREM2 and mechanisms underlying TREM2 activity as contributing to neurodegeneration. These findings may provide novel insights and opportunities to consider, especially for clinicians, as they diagnose and treat certain neurological diseases.
authors.affiliation: a Department of Pharmacology , School of Medicine, Shandong University , Jinan 250012 , China.|b Department of Radiation Oncology , Shandong Cancer Hospital and Institute affiliated to Shandong University , Jinan 250012 , China.
authors.forename: Jie
authors.initials: J
authors.lastname: Han
authors.affiliation: c Department of Hematology , Qilu Hospital, Shandong University , Jinan 250012 , China.
authors.forename: Miaomiao
authors.initials: M
authors.lastname: Wang
authors.affiliation: a Department of Pharmacology , School of Medicine, Shandong University , Jinan 250012 , China.
authors.forename: Manru
authors.initials: M
authors.lastname: Ren
authors.affiliation: a Department of Pharmacology , School of Medicine, Shandong University , Jinan 250012 , China.
authors.forename: Haiyan
authors.initials: H
authors.lastname: Lou
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism; D006801:Humans; D008562:Membrane Glycoproteins / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism; D017628:Microglia / Q000378:metabolism; D009422:Nervous System Diseases / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology; D011971:Receptors, Immunologic / Q000378:metabolism*
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D011971:Receptors, Immunologic; C498715:TREM2 protein, human; C110546:TYROBP protein, human
keywords: DAP12; TREM2; microglia; neurological diseases