title: [Comparison of the prognosis after hepatic resection for patients with Barcelona Clinical Liver Cancer Stage B hepatocellular carcinoma].
abstract: Objective:To compare the efficacy of hepatic resection (HR) in patients with Barcelona Clinical Liver Cancer (BCLC) Stage B hepatocellular carcinoma (HCC) and examine how that efficacy has changed over time in a large medical center.Methods:A consecutive sample of 918 patients with preserved liver function and large and/or multinodular HCC who were treated by initial HR were divided into three groups: those with a single tumor ≥5 cm in diameter (n=582), 2-3 tumors with a maximum diameter>3 cm (n=223), or>3 tumors of any diameter (n=113). Hospital mortality and overall survival (OS) in each group were compared for the years 2001-2007 and 2008-2013.Results:Patients with >3 tumors showed the highest incidence of hospital mortality of all groups (P<0.05). Kaplan-Meier survival analysis showed that OS varied across the three groups as follows: single tumor>2-3 tumors >3+ tumors (allP<0.05). OS rate at 5 years ranged from 24% to 41% in all three groups for the period 2001-2007, and from 35% to 46% for the period 2008-2013. OS was significantly higher during the more recent 6-year period in the entire patient population, those with single tumor, and those with 3+ tumors (allP<0.05). However, in patients with 2-3 tumors, OS was only slightly higher during the more recent 6-year period (P=0.084).Conclusions:Prognosis of three types of HCC was different. Patients with >3 tumors show the highest hospital mortality and lowest OS after HR. OS has been improving for all three types of HCC at our medical center as a consequence of improvements in surgical technique and perioperative management.
authors.affiliation: Hepatobiliary Surgery Department, Affiliated Tumor Hospital of Guangxi Medical University, Guangxi Liver Cancer Diagnosis and Treatment Engineering and Technology Research Center, Nanning 530021, China.
authors.forename: H G
authors.initials: HG
authors.lastname: Qin
authors.forename: J H
authors.initials: JH
authors.lastname: Zhong
authors.forename: B D
authors.initials: BD
authors.lastname: Xiang
authors.forename: F X
authors.initials: FX
authors.lastname: Wu
authors.forename: N F
authors.initials: NF
authors.lastname: Peng
authors.forename: X M
authors.initials: XM
authors.lastname: You
authors.forename: W P
authors.initials: WP
authors.lastname: Yuan
authors.forename: W F
authors.initials: WF
authors.lastname: Gong
authors.forename: L
authors.initials: L
authors.lastname: Ma
authors.forename: L Q
authors.initials: LQ
authors.lastname: Li
mesh_terms: D006528:Carcinoma, Hepatocellular; D017052:Hospital Mortality; D006801:Humans; D053208:Kaplan-Meier Estimate; D008113:Liver Neoplasms; D011379:Prognosis; D015996:Survival Rate