title: Chromatin-bound MDM2, a new player in metabolism.
abstract: The oncoprotein MDM2 is recognized as a major negative regulator of the p53 tumor suppressor but growing evidence indicates that its oncogenic activities extend beyond p53. We show that MDM2 is recruited to chromatin independently of p53 to regulate a transcriptional program implicated in amino acid metabolism and redox homeostasis.
authors.affiliation: IRCM, Institut de Recherche en Cancérologie de Montpellier, Montpellier, F-34298, France; INSERM, U1194, Montpellier, F-34298, France; Université Montpellier, Montpellier, F-34298, France; Institut régional du Cancer Montpellier, Montpellier, F-34298, France.
authors.forename: Romain
authors.initials: R
authors.lastname: Riscal
authors.affiliation: IRCM, Institut de Recherche en Cancérologie de Montpellier, Montpellier, F-34298, France; INSERM, U1194, Montpellier, F-34298, France; Université Montpellier, Montpellier, F-34298, France; Institut régional du Cancer Montpellier, Montpellier, F-34298, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Le Cam
authors.affiliation: IRCM, Institut de Recherche en Cancérologie de Montpellier, Montpellier, F-34298, France; INSERM, U1194, Montpellier, F-34298, France; Université Montpellier, Montpellier, F-34298, France; Institut régional du Cancer Montpellier, Montpellier, F-34298, France.
authors.forename: Laetitia K
authors.initials: LK
authors.lastname: Linares
keywords: Cancer; Mdm2; chromatin; metabolism; redox