title: The validity of suspected blood indicator software in capsule endoscopy: a systematic review and meta-analysis.
abstract: Software tools have been developed as capsule endoscopy (CE) reading aids. The suspected blood indicator (SBI) tags possible areas of haemorrhage in the gastrointestinal (GI) tract. This meta-analysis aims to investigate the diagnostic accuracy of SBI in CE. Areas covered: A systematic literature search was conducted for studies on the use of SBI in CE. Sensitivity, specificity and diagnostic odds ratio (DOR) of SBI in diagnosing GI bleeding was evaluated. 2040 patients from 16 studies underwent 2049 CE examinations. The overall sensitivity of SBI for bleeding or potentially bleeding lesions was 0.553, specificity 0.578, DOR 12.354. The sensitivity of SBI for active bleeding was 0.988, specificity 0.646, DOR 229.89. Expert commentary: Currently, SBI has limited validity in CE reading. However, in active GI bleeding, it has good sensitivity, supporting its use in the acute setting.
authors.affiliation: a Centre for Liver & Digestive Disorders , The Royal Infirmary of Edinburgh , Edinburgh , UK.
authors.forename: Diana E
authors.initials: DE
authors.lastname: Yung
authors.affiliation: a Centre for Liver & Digestive Disorders , The Royal Infirmary of Edinburgh , Edinburgh , UK.
authors.forename: Catherine
authors.initials: C
authors.lastname: Sykes
authors.affiliation: a Centre for Liver & Digestive Disorders , The Royal Infirmary of Edinburgh , Edinburgh , UK.
authors.forename: Anastasios
authors.initials: A
authors.lastname: Koulaouzidis
mesh_terms: D019540:Area Under Curve; D053704:Capsule Endoscopy / Q000379:methods*; D006471:Gastrointestinal Hemorrhage / Q000000981:diagnostic imaging* / Q000209:etiology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D016017:Odds Ratio; D011237:Predictive Value of Tests; D012372:ROC Curve; D015203:Reproducibility of Results; D012307:Risk Factors; D012984:Software
keywords: Capsule endoscopy; meta-analysis; obscure gastrointestinal bleeding; small bowel bleeding; suspected blood indicator; systematic review