title: Papillomavirus assembly: An overview and perspectives.
abstract: Papillomavirus life cycle is tightly coupled to epithelial cell differentiation, which has hindered the investigation of many aspects of papillomavirus biology, including virion assembly. The development of in vitro production methods of papillomavirus pseudoviruses, and the production of "native" virus in raft cultures have facilitated the study of some aspects of the assembly process. In this paper we review the current knowledge of papillomavirus assembly, directions for future research, and the implications of these studies on new therapeutic interventions.
authors.affiliation: Laboratory of Cellular Oncology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
authors.forename: Carla
authors.initials: C
authors.lastname: Cerqueira
authors.affiliation: Laboratory of Cellular Oncology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: schillej@mail.nih.gov.
authors.forename: John T
authors.initials: JT
authors.lastname: Schiller
mesh_terms: D036022:Capsid Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D002454:Cell Differentiation; D016679:Genome, Viral; D054884:Host-Pathogen Interactions; D006801:Humans; D015603:Keratinocytes / Q000378:metabolism / Q000821:virology; D027383:Papillomaviridae / Q000235:genetics* / Q000254:growth & development / Q000472:pathogenicity / Q000648:ultrastructure; D030361:Papillomavirus Infections / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000821:virology; D014771:Virion / Q000235:genetics* / Q000254:growth & development / Q000472:pathogenicity / Q000648:ultrastructure; D019065:Virus Assembly; D014779:Virus Replication
chemical_list: D036022:Capsid Proteins
keywords: Papillomavirus; Pseudovirus; Virion assembly