title: A novel electrochemical biomimetic sensor based on poly(Cu-AMT) with reduced graphene oxide for ultrasensitive detection of dopamine.
abstract: A polymerized film of copper-2-amino-5-mercapto-1,3,4-thiadiazole (Cu(II)-AMT) complex (poly(Cu-AMT)) was successfully achieved via a simple and low-cost electrochemical methodology. Subsequently, a noncovalent nanohybrid of poly(Cu-AMT) with reduced graphene oxide (rGO) (rGO-poly(Cu-AMT)) was prepared through π-π stacking interaction as an efficient mimetic enzyme for the ultrasensitive and selective detection of dopamine (DA). The rGO-poly(Cu-AMT) nanocomposites showed considerable mimetic enzyme catalytic activity, which may be attributed to the significant promotion of the electron transfer between the substrate and graphene-based carbon materials, and also the synergistic electrocatalytic effect in mimetic enzyme between rGO sheet and poly(Cu-AMT). The electrocatalytic and sensing performances of the biomimetic sensor based on the rGO-poly(Cu-AMT) nanocomposites were evaluated in detail. The biomimetic sensor enables a reliable and sensitive determination of DA with a linear range of 0.01-40μM and a detection limit of 3.48nM at a signal-to-noise ratio of 3. In addition, we applied the proposed method to detect DA in real sample with satisfactory results. Accordingly, the rGO-poly(Cu-AMT) is one of the promising mimetic enzyme for electrocatalysis and biosensing.
authors.affiliation: College of Chemistry, Jilin University, Changchun 130012, China.
authors.forename: Yaru
authors.initials: Y
authors.lastname: Li
authors.affiliation: College of Chemistry, Jilin University, Changchun 130012, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Gu
authors.affiliation: College of Chemistry, Jilin University, Changchun 130012, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Zheng
authors.affiliation: College of Chemistry, Jilin University, Changchun 130012, China.
authors.forename: Lan
authors.initials: L
authors.lastname: Luo
authors.affiliation: College of Chemistry, Jilin University, Changchun 130012, China.
authors.forename: Cong
authors.initials: C
authors.lastname: Li
authors.affiliation: College of Chemistry, Jilin University, Changchun 130012, China.
authors.forename: Xiaoyi
authors.initials: X
authors.lastname: Yan
authors.affiliation: College of Chemistry, Jilin University, Changchun 130012, China.
authors.forename: Tingting
authors.initials: T
authors.lastname: Zhang
authors.affiliation: College of Chemistry, Jilin University, Changchun 130012, China.
authors.forename: Nannan
authors.initials: N
authors.lastname: Lu
authors.affiliation: College of Chemistry, Jilin University, Changchun 130012, China. Electronic address: zzq@jlu.edu.cn.
authors.forename: Zhiquan
authors.initials: Z
authors.lastname: Zhang
mesh_terms: D032701:Biomimetics / Q000379:methods; D015374:Biosensing Techniques / Q000379:methods*; D003300:Copper / Q000737:chemistry; D004298:Dopamine / Q000032:analysis*; D055664:Electrochemical Techniques / Q000379:methods*; D006108:Graphite / Q000737:chemistry*; D053761:Nanocomposites / Q000737:chemistry / Q000648:ultrastructure; D009942:Organometallic Compounds / Q000737:chemistry*; D010087:Oxides / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D015203:Reproducibility of Results; D017550:Spectroscopy, Fourier Transform Infrared; D013830:Thiadiazoles / Q000737:chemistry; D014961:X-Ray Diffraction
chemical_list: D009942:Organometallic Compounds; D010087:Oxides; D011108:Polymers; D013830:Thiadiazoles; D006108:Graphite; D003300:Copper; C000592181:2-amino-5-mercapto-1,3,4-thiadiazole; D004298:Dopamine
keywords: Biomimetic sensor; Copper; Dopamine; Electrochemistry; Reduced graphene oxide