title: The Efficacy of Platelet-Derived Growth Factor as a Bone-Stimulating Agent.
abstract: Nonunion remains the most impactful complication following ankle and hindfoot arthrodesis. Historically, surgeons have relied on autologous bone graft (ABG) to combat nonunion risk. Although effective, ABG remains limited in quantity, varies in quality, and can be associated with harvest site pain and morbidity. Use of alternative bone-stimulating agents, however, avoids harvesting an autograft, and provides a more predictable dose-response efficacy. This article highlights findings from basic science, animal, and human clinical research that led to the approval of Augment Bone Graft. We present an adaptation of the surgical techniques described for investigators participating in the pivotal trial.
authors.affiliation: Department of Orthopaedics, Rutgers New Jersey Medical School, Newark, NJ, USA.
authors.forename: Ethan S
authors.initials: ES
authors.lastname: Krell
authors.affiliation: Division of Foot and Ankle Surgery, Department of Orthopaedic Surgery, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA. Electronic address: CWDiGiovanni@MGH.Harvard.edu.
authors.forename: Christopher W
authors.initials: CW
authors.lastname: DiGiovanni
mesh_terms: D000818:Animals; D000842:Ankle / Q000601:surgery; D001174:Arthrodesis; D000077214:Becaplermin; D050071:Bone Density Conservation Agents / Q000494:pharmacology / Q000627:therapeutic use*; D016025:Bone Transplantation; D002130:Calcium Phosphates / Q000494:pharmacology* / Q000627:therapeutic use; D005528:Foot / Q000601:surgery; D017102:Fracture Healing / Q000187:drug effects* / Q000502:physiology; D005599:Fractures, Ununited / Q000188:drug therapy* / Q000601:surgery; D006801:Humans; D020574:Proto-Oncogene Proteins c-sis / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D014945:Wound Healing / Q000187:drug effects / Q000502:physiology
chemical_list: D050071:Bone Density Conservation Agents; D002130:Calcium Phosphates; D020574:Proto-Oncogene Proteins c-sis; C485817:beta-tricalcium phosphate; D000077214:Becaplermin
keywords: Bone graft substitute; Foot and ankle arthrodesis; Fusion; Platelet-derived growth factor; rhPDGF-BB