title: Thermo-sensitive injectable hydrogel based on the physical mixing of hyaluronic acid and Pluronic F-127 for sustained NSAID delivery.
abstract: The aim of this research is the development of a new type of intra-articularly injectable thermo-sensitive hydrogels for the long-term delivery of Piroxicam (PX). The thermo-sensitive hydrogel was prepared by the simple physical mixing of HA and Pluronic F-127 (HP) in aqueous solution. The addition of high-molecular-weight HA not only enhanced the mechanical strength of the hydrogel but also elicited a sustained drug release. This result could be attributed to the high-molecular-weight HA-assisted inter-micellar packing in the hydrogel inner structure. The critical gelation temperature value of HP hydrogel was considerably lower than native Pluronic F-127. To evaluate the bioavailability, pharmacokinetic parameters were analyzed after articular-cavity injection of the HP hydrogel in beagle dogs. The HP hydrogel exhibits both sustained drug release behavior and superior bioavailability in physiological conditions. Thus, we believe that the NSAID PX-loaded HP hydrogel could be a promising hydrogel-based drug delivery platform for the treatment of arthritis.
authors.affiliation: Department of Biotechnology, The Catholic University of Korea, 43 Jibong-Ro, Wonmi-Gu, Bucheon-Si, Gyeonggi-Do 14662, Republic of Korea.
authors.forename: Young-Seok
authors.initials: YS
authors.lastname: Jung
authors.affiliation: Department of Biotechnology, The Catholic University of Korea, 43 Jibong-Ro, Wonmi-Gu, Bucheon-Si, Gyeonggi-Do 14662, Republic of Korea.
authors.forename: Wooram
authors.initials: W
authors.lastname: Park
authors.affiliation: Department of Biotechnology, The Catholic University of Korea, 43 Jibong-Ro, Wonmi-Gu, Bucheon-Si, Gyeonggi-Do 14662, Republic of Korea.
authors.forename: Hyejin
authors.initials: H
authors.lastname: Park
authors.affiliation: Dongkook Pharm. Co., Gyeonggi Bio-Center, 147, Gwanggyo-Ro, Yeongtong-Gu, Suwon-Si, Gyeonggi-Do 16229, Republic of Korea.
authors.forename: Deok-Keun
authors.initials: DK
authors.lastname: Lee
authors.affiliation: Department of Biotechnology, The Catholic University of Korea, 43 Jibong-Ro, Wonmi-Gu, Bucheon-Si, Gyeonggi-Do 14662, Republic of Korea. Electronic address: kna6997@catholic.ac.kr.
authors.forename: Kun
authors.initials: K
authors.lastname: Na
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage; D004337:Drug Carriers / Q000737:chemistry*; D006820:Hyaluronic Acid / Q000737:chemistry*; D020100:Hydrogels / Q000138:chemical synthesis / Q000737:chemistry*; D020442:Poloxamer / Q000737:chemistry*; D013696:Temperature
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004337:Drug Carriers; D020100:Hydrogels; D020442:Poloxamer; D006820:Hyaluronic Acid
keywords: Arthritis; Hyaluronic acid (HA); NSAID; Pluronic F-127; Thermo-sensitive hydrogel