title: A Case of Complete Abscopal Response in High-Grade Pleiomorphic Sarcoma Treated with Radiotherapy Alone.
abstract: BACKGROUND
  "Abscopal response" refers to the spontaneous involution of untreated metastatic disease following local primary tumor-directed therapy. We report a case of an abscopal response of untreated lung metastasis in a man with pleomorphic sarcoma of the head and neck treated with hypofractionated radiotherapy.
  
  
  METHODS
  An inoperable pleomorphic sarcoma of the postauricular soft tissue was treated with 40 Gy of radiation in eight fractions. Untreated disease in the lungs was followed with CT scans.
  
  
  RESULTS
  At the two-month post-treatment follow-up, clinical exam and restaging CT demonstrated complete primary tumor involution. Additionally, CT chest images showed a dramatic disease response in the untreated pulmonary disease, which progressed to complete and persistent clinical response at one-year post-treatment follow-up.
  
  
  CONCLUSIONS
  We report the first described case of a complete abscopal resolution of untreated lung metastases in a patient with a primary pleomorphic sarcoma of the head and neck treated with hypofractionated radiotherapy.
authors.affiliation: Radiation Oncology, University of Utah School of Medicine, Huntsman Cancer Institute.
authors.forename: Andrew
authors.initials: A
authors.lastname: Orton
authors.affiliation: Medical Oncology, University of Utah School of Medicine, Huntsman Cancer Institute.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Wright
authors.affiliation: Department of Otolaryngology, University of Utah School of Medicine, Huntsman Cancer Institute.
authors.forename: Luke
authors.initials: L
authors.lastname: Buchmann
authors.affiliation: Department of Orthopaedic Surgery/Sarcoma, University of Utah School of Medicine, Huntsman Cancer Institute.
authors.forename: Lor
authors.initials: L
authors.lastname: Randall
authors.affiliation: Radiation Oncology, University of Utah School of Medicine, Huntsman Cancer Institute.
authors.forename: Ying J
authors.initials: YJ
authors.lastname: Hitchcock
keywords: abscopal; head and neck cancer; radiotherapy; sarcoma