title: Dysarthria in individuals with Parkinson's disease: a protocol for a binational, cross-sectional, case-controlled study in French and European Portuguese (FraLusoPark).
abstract: Individuals with Parkinson's disease (PD) have to deal with several aspects of voice and speech decline and thus alteration of communication ability during the course of the disease. Among these communication impairments, 3 major challenges include: (1) dysarthria, consisting of orofacial motor dysfunction and dysprosody, which is linked to the neurodegenerative processes; (2) effects of the pharmacological treatment, which vary according to the disease stage; and (3) particular speech modifications that may be language-specific, that is, dependent on the language spoken by the patients. The main objective of the FraLusoPark project is to provide a thorough evaluation of changes in PD speech as a result of pharmacological treatment and disease duration in 2 different languages (French vs European Portuguese).
  
  
  
  Individuals with PD are enrolled in the study in France (N=60) and Portugal (N=60). Their global motor disability and orofacial motor functions is assessed with specific clinical rating scales, without (OFF) and with (ON) pharmacological treatment. 2 groups of 60 healthy age-matched volunteers provide the reference for between-group comparisons. Along with the clinical examinations, several speech tasks are recorded to obtain acoustic and perceptual measures. Patient-reported outcome measures are used to assess the psychosocial impact of dysarthria on quality of life.
  
  
  
  The study has been approved by the local responsible committees on human experimentation and is conducted in accordance with the ethical standards. A valuable large-scale database of speech recordings and metadata from patients with PD in France and Portugal will be constructed. Results will be disseminated in several articles in peer-reviewed journals and in conference presentations. Recommendations on how to assess speech and voice disorders in individuals with PD to monitor the progression and management of symptoms will be provided.
  
  
  
  NCT02753192, Pre-results.
authors.affiliation: Aix Marseille Université, Centre National de la Recherche Scientifique (CNRS), Laboratoire Parole et Langage (LPL), Aix-en-Provence, France.|Brain and Language Research Institute, Aix-en-Provence, France.
authors.forename: Serge
authors.identifier: 0000-0002-3375-4787
authors.initials: S
authors.lastname: Pinto
authors.affiliation: Campus Neurológico Sénior (CNS), Torres Vedras, Portugal.|Faculty of Medicine, Instituto de Medicina Molecular (IMM), University of Lisbon, Lisbon, Portugal.
authors.forename: Rita
authors.initials: R
authors.lastname: Cardoso
authors.affiliation: Aix Marseille Université, Centre National de la Recherche Scientifique (CNRS), Laboratoire Parole et Langage (LPL), Aix-en-Provence, France.|Brain and Language Research Institute, Aix-en-Provence, France.
authors.forename: Jasmin
authors.identifier: 0000-0002-3398-606X
authors.initials: J
authors.lastname: Sadat
authors.affiliation: Faculty of Medicine, Instituto de Medicina Molecular (IMM), University of Lisbon, Lisbon, Portugal.|Speech Therapy Department, Escola Superior de Saude do Alcoitão, Alcabideche, Portugal.
authors.forename: Isabel
authors.identifier: 0000-0001-8524-8731
authors.initials: I
authors.lastname: Guimarães
authors.affiliation: Aix Marseille Université, Centre National de la Recherche Scientifique (CNRS), Laboratoire Parole et Langage (LPL), Aix-en-Provence, France.|Neurology Department, Centre Hospitalier du Pays d'Aix, Aix-en-Provence, France.
authors.forename: Céline
authors.initials: C
authors.lastname: Mercier
authors.affiliation: Campus Neurológico Sénior (CNS), Torres Vedras, Portugal.
authors.forename: Helena
authors.initials: H
authors.lastname: Santos
authors.affiliation: Aix Marseille Université, Centre National de la Recherche Scientifique (CNRS), Laboratoire Parole et Langage (LPL), Aix-en-Provence, France.|Brain and Language Research Institute, Aix-en-Provence, France.
authors.forename: Cyril
authors.initials: C
authors.lastname: Atkinson-Clement
authors.affiliation: Campus Neurológico Sénior (CNS), Torres Vedras, Portugal.
authors.forename: Joana
authors.initials: J
authors.lastname: Carvalho
authors.affiliation: Aix Marseille Université, Centre National de la Recherche Scientifique (CNRS), Laboratoire Parole et Langage (LPL), Aix-en-Provence, France.|Brain and Language Research Institute, Aix-en-Provence, France.
authors.forename: Pauline
authors.initials: P
authors.lastname: Welby
authors.affiliation: Faculty of Medicine, Instituto de Medicina Molecular (IMM), University of Lisbon, Lisbon, Portugal.|Centre of Linguistics, School of Arts and Humanities, University of Lisbon, Lisbon, Portugal.
authors.forename: Pedro
authors.initials: P
authors.lastname: Oliveira
authors.affiliation: Aix Marseille Université, Centre National de la Recherche Scientifique (CNRS), Laboratoire Parole et Langage (LPL), Aix-en-Provence, France.|Brain and Language Research Institute, Aix-en-Provence, France.
authors.forename: Mariapaola
authors.initials: M
authors.lastname: D'Imperio
authors.affiliation: Centre of Linguistics, School of Arts and Humanities, University of Lisbon, Lisbon, Portugal.
authors.forename: Sónia
authors.initials: S
authors.lastname: Frota
authors.affiliation: Aix Marseille Université, Centre National de la Recherche Scientifique (CNRS), Laboratoire Parole et Langage (LPL), Aix-en-Provence, France.
authors.forename: Alban
authors.initials: A
authors.lastname: Letanneux
authors.affiliation: Centre of Linguistics, School of Arts and Humanities, University of Lisbon, Lisbon, Portugal.
authors.forename: Marina
authors.initials: M
authors.lastname: Vigario
authors.affiliation: Centre of Linguistics, School of Arts and Humanities, University of Lisbon, Lisbon, Portugal.
authors.forename: Marisa
authors.initials: M
authors.lastname: Cruz
authors.affiliation: Neurology Department, Faculty of Medicine, Language Research Laboratory, University of Lisbon, Lisbon, Portugal.
authors.forename: Isabel Pavão
authors.initials: IP
authors.lastname: Martins
authors.affiliation: Aix Marseille Université, Centre National de la Recherche Scientifique (CNRS), Laboratoire Parole et Langage (LPL), Aix-en-Provence, France.|Brain and Language Research Institute, Aix-en-Provence, France.|Neurology Department, Centre Hospitalier du Pays d'Aix, Aix-en-Provence, France.
authors.forename: François
authors.initials: F
authors.lastname: Viallet
authors.affiliation: Campus Neurológico Sénior (CNS), Torres Vedras, Portugal.|Faculty of Medicine, Instituto de Medicina Molecular (IMM), University of Lisbon, Lisbon, Portugal.
authors.forename: Joaquim J
authors.identifier: 0000-0003-3950-5113
authors.initials: JJ
authors.lastname: Ferreira
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D018450:Disease Progression; D004401:Dysarthria / Q000188:drug therapy*; D005260:Female; D005602:France; D006801:Humans; D007802:Language; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications* / Q000503:physiopathology*; D011174:Portugal; D011788:Quality of Life; D012107:Research Design; D013060:Speech / Q000187:drug effects
keywords: Cross-language; Disease progression; Dysarthria; Parkinson’s disease; Pharmacological treatment; Speech