title: Triterpene glycosides from the aerial parts of Gouania longipetala.
abstract: Six previously undescribed triterpenoid saponins, gouaniaside I-VI, were isolated from the aerial parts of Gouania longipetala Hemsl. (Rhamnaceae), in addition to four known triterpenes. The structure elucidation of these compounds was based on analyses of spectroscopic data including 1D- and 2D-NMR and HR-ESI-MS techniques. The inhibitory activity of isolated compounds against promyelocytic leukemia HL60 and human erythromyeloblastoid leukemia K562 cell lines was evaluated and jujuboside I exhibited moderate cytotoxicity, with IC50values of 13.5 and 21.0 μM, respectively. Among the isolated triterpenes, alphitolic acid exhibited moderate antibacterial activity against Staphylococcus aureus, Enterococcus faecalis and Escherichia coli (MICs 32, 64 and 128 μg/mL, respectively).
authors.affiliation: ICMR-UMR CNRS 7312, Groupe Isolement et Structure, Campus Sciences, Bât. 18, BP 1039, 51687 Reims, France; Laboratoire de Chimie Organique et de Substances Naturelles, Université Félix-Houphouët Boigny d'Abidjan-Cocody, 22 BP 582 Abidjan 22, Cote d'Ivoire.
authors.forename: Diane Patricia Apie
authors.initials: DP
authors.lastname: Gossan
authors.affiliation: ICMR-UMR CNRS 7312, Groupe Isolement et Structure, Campus Sciences, Bât. 18, BP 1039, 51687 Reims, France. Electronic address: abdulmagid.alabdulmagid@univ-reims.fr.
authors.forename: Abdulmagid
authors.initials: A
authors.lastname: Alabdul Magid
authors.affiliation: Laboratoire de Chimie Organique et de Substances Naturelles, Université Félix-Houphouët Boigny d'Abidjan-Cocody, 22 BP 582 Abidjan 22, Cote d'Ivoire.
authors.forename: Philomène Akoua
authors.initials: PA
authors.lastname: Yao-Kouassi
authors.affiliation: Laboratoire de Chimie Organique et de Substances Naturelles, Université Félix-Houphouët Boigny d'Abidjan-Cocody, 22 BP 582 Abidjan 22, Cote d'Ivoire.
authors.forename: Antoine
authors.initials: A
authors.lastname: Ahibo Coffy
authors.affiliation: EA 4691, «Biomatériaux et inflammation en site osseux», Laboratoire de microbiologie, UFR de pharmacie, 1, rue du Maréchal-Juin, 51096 Reims, France.
authors.forename: Jérome
authors.initials: J
authors.lastname: Josse
authors.affiliation: EA 4691, «Biomatériaux et inflammation en site osseux», Laboratoire de microbiologie, UFR de pharmacie, 1, rue du Maréchal-Juin, 51096 Reims, France.
authors.forename: Sophie C
authors.initials: SC
authors.lastname: Gangloff
authors.affiliation: MEDyC UMR CNRS 7369, URCA, Faculté de Pharmacie, SFR CAP Santé, 1, rue du Maréchal-Juin, 51096 Reims, France.
authors.forename: Hamid
authors.initials: H
authors.lastname: Morjani
authors.affiliation: ICMR-UMR CNRS 7312, Groupe Isolement et Structure, Campus Sciences, Bât. 18, BP 1039, 51687 Reims, France.
authors.forename: Laurence
authors.initials: L
authors.lastname: Voutquenne-Nazabadioko
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D013293:Enterococcus faecalis / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018922:HL-60 Cells; D006801:Humans; D020014:K562 Cells; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D035261:Plant Components, Aerial / Q000737:chemistry*; D027823:Rhamnaceae / Q000737:chemistry*; D012503:Saponins; D013211:Staphylococcus aureus / Q000187:drug effects; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D000972:Antineoplastic Agents, Phytogenic; D006027:Glycosides; D012503:Saponins; D014315:Triterpenes; C000614552:alphitolic acid; C000614553:jujuboside I; C087808:jujuboside A
keywords: Antibacterial activity; Cytotoxic activity; Gouania longipetala; Rhamnaceae; Triterpenoids