title: Ultrasound elastography: is there a shear wave speed cutoff for pediatric liver fibrosis and inflammation?
abstract: OBJECTIVE
  The objective was to identify a shear wave speed (SWS) cutoff in pediatric liver disease to detect fibrosis and inflammation.
  
  
  METHODS
  We performed an institutional-review-board-approved prospective study of liver SWS in 41 children undergoing liver biopsy.
  
  
  RESULTS
  In patients without inflammation, SWS was higher when fibrosis was present compared to when fibrosis was not present (average SWS 1.8 vs. 1.4 m/s, respectively, P=.02). A SWS cutoff of 1.7 m/s had 100% positive predictive value and 24% negative predictive value for detecting fibrosis or inflammation.
  
  
  CONCLUSIONS
  Point shear wave elastography is an insufficient stand-alone screening tool for liver fibrosis and inflammation in a heterogeneous patient population.
authors.affiliation: UCSF Benioff Children's Hospital, University of California, San Francisco, San Francisco, CA, 94158. Electronic address: Andrew.Phelps@ucsf.edu.
authors.forename: Andrew
authors.initials: A
authors.lastname: Phelps
authors.affiliation: UCSF Benioff Children's Hospital, University of California, San Francisco, San Francisco, CA, 94158. Electronic address: Raga.Ramachandran@ucsf.edu.
authors.forename: Raga
authors.initials: R
authors.lastname: Ramachandran
authors.affiliation: UCSF Benioff Children's Hospital, University of California, San Francisco, San Francisco, CA, 94158. Electronic address: Jesse.Courtier@ucsf.edu.
authors.forename: Jesse
authors.initials: J
authors.lastname: Courtier
authors.affiliation: UCSF Benioff Children's Hospital, University of California, San Francisco, San Francisco, CA, 94158. Electronic address: Emily.Perito@ucsf.edu.
authors.forename: Emily
authors.initials: E
authors.lastname: Perito
authors.affiliation: UCSF Benioff Children's Hospital, University of California, San Francisco, San Francisco, CA, 94158. Electronic address: PRosenth@ucsf.edu.
authors.forename: Philip
authors.initials: P
authors.lastname: Rosenthal
authors.affiliation: UCSF Benioff Children's Hospital, University of California, San Francisco, San Francisco, CA, 94158. Electronic address: John.MacKenzie@ucsf.edu.
authors.forename: John D
authors.initials: JD
authors.lastname: MacKenzie
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D054459:Elasticity Imaging Techniques / Q000379:methods*; D005260:Female; D006801:Humans; D007223:Infant; D007249:Inflammation / Q000000981:diagnostic imaging* / Q000473:pathology; D008103:Liver Cirrhosis / Q000000981:diagnostic imaging* / Q000473:pathology; D008107:Liver Diseases / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D011446:Prospective Studies; D055815:Young Adult
keywords: ARFI; Elastography; Shear wave speed; pSWE