title: [Geographic distribution of perinatal mortality due to congenital malformations in Colombia, 1999-2008: An analysis of vital statistics data].
abstract: BACKGROUND
  During 2012, 13% of the deaths worldwide in children under the age of 28 days were due to congenital malformations. In Colombia, congenital malformations are the second leading cause of infant mortality. Objective: To determine the geographical distribution of extended perinatal mortality due to congenital malformations in Colombia between 1999 and 2008. Materials and methods: We conducted a cross-sectional study. We revised all death certificates issued between 1999 and 2008. We defined perinatal mortality as fetal or non-fetal deaths within the first 28 days after delivery in children with body weight ≥500 grams, and congenital malformations according to ICD-10 diagnostic codes Q000 - Q999. The annual birth projection was used as the denominator. We defined high mortality areas due to congenital malformations as those in the 90th percentile. Results: We recorded 22,361 perinatal deaths due to congenital malformations. The following provinces exceeded the 90th perinatal mortality percentile: Antioquia, Caldas, Risaralda, Huila, Quindío, Bogotá, Valle del Cauca and Guainía. Among the municipalities, the highest perinatal mortality rates were found in Giraldo, Ciudad Bolívar, Riosucio, Liborina, Supía, Alejandría, Sopetrán, San Jerónimo, Santa Fe de Antioquia and Marmato (205.81 and 74.18 per 10.000 live births).The perinatal mortality rate due to malformations of the circulatory system was 28.1 per 10.000 live births, whereas the rates for central nervous system defects and chromosomal abnormalities were 13.7 and 7.0, respectively.
  
  
  CONCLUSIONS
  The Andean region showed high perinatal mortality rates due to congenital malformations. There is an urgent need to identify possible risk factors of perinatal mortality and implement successive prevention programs in that particular region.
authors.affiliation: Programa de Entrenamiento en Epidemiología de Campo, Colombia, Grupo de Investigación en Epidemiología Aplicada, Instituto Nacional de Salud, Bogotá, D.C., Colombia. sandramisnaza@yahoo.com.
authors.forename: Sandra Patricia
authors.initials: SP
authors.lastname: Misnaza
authors.forename: Claudia Patricia
authors.initials: CP
authors.lastname: Roncancio
authors.forename: Isabel Cristina
authors.initials: IC
authors.lastname: Peña
authors.forename: Franklin Edwin
authors.initials: FE
authors.lastname: Prieto
mesh_terms: D003105:Colombia; D000013:Congenital Abnormalities / Q000401:mortality*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007223:Infant; D007226:Infant Mortality; D007231:Infant, Newborn; D008297:Male; D054238:Perinatal Mortality; D011247:Pregnancy; D011295:Prenatal Care
keywords: Colombia; Congenital abnormalities; fetal mortality; infant mortality; mortality; vital statistics