title: β-Catenin Expression Negatively Correlates with WIF1 and Predicts Poor Clinical Outcomes in Patients with Cervical Cancer.
abstract: Aberrant activation of the canonical Wnt pathway plays a significant role in cervical cancer (CC). However, limited data show the correlation between the cancer clinicopathological characteristics and the key molecules such asβ-catenin and Wnt inhibitory factor 1 (WIF1). In this study,β-cateninandWIF1expression were analyzed by immunohistochemistry for 196 patients with CC, 39 with cervical intraepithelial neoplasia (CIN), and 41 with normal cervical epithelium (NCE). Significant overexpression ofβ-cateninwas detected in CC (67.9%) when compared to CIN (43.6%) or NCE (34.1%),p< 0.01, while lowWIF1expression was detected in CC (24.0%) when compared to CIN (59.0%) or NCE (58.5%),p< 0.001. Negative correlation was shown betweenβ-cateninandWIF1expression (r= -0.637,p< 0.001). In addition, multivariate analysis revealed that both lymph node metastasis andβ-cateninexpression were the independent prognostic factors not only for disease-free survival (HR = 5.029,p< 0.001; HR = 2.588,p= 0.035, resp.), but also for overall survival (HR = 5.058,p< 0.001; HR = 2.873,p= 0.031, resp.). Our findings indicate that, besides lymph node metastasis,β-catenin expression may also be a poor prognostic factor for CC while WIF1 could be a potential drug target for treatment of advanced CC.
authors.affiliation: Department of Gynecologic Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China; Key Laboratory of Malignant Tumor Gene Regulation and Target Therapy of Guangdong Higher Education Institutes, Sun Yat-Sen University, Guangzhou, China.
authors.forename: Jinxiao
authors.initials: J
authors.lastname: Liang
authors.affiliation: Department of Gynecologic Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Zhou
authors.affiliation: Department of Gynecologic Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
authors.forename: Yongpai
authors.initials: Y
authors.lastname: Peng
authors.affiliation: Department of Gynecologic Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
authors.forename: Xiaofei
authors.initials: X
authors.lastname: Xie
authors.affiliation: Department of Gynecologic Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
authors.forename: Ruixin
authors.initials: R
authors.lastname: Li
authors.affiliation: Department of Gynecologic Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
authors.forename: Yunyun
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Gynecologic Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China; Key Laboratory of Malignant Tumor Gene Regulation and Target Therapy of Guangdong Higher Education Institutes, Sun Yat-Sen University, Guangzhou, China.
authors.forename: Qingsheng
authors.identifier: 0000-0002-5079-9143
authors.initials: Q
authors.lastname: Xie
authors.affiliation: Department of Gynecologic Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
authors.forename: Zhongqiu
authors.identifier: 0000-0002-9891-2854
authors.initials: Z
authors.lastname: Lin
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism*; D000328:Adult; D018572:Disease-Free Survival; D005260:Female; D058685:Genetic Pleiotropy; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008938:Mitosis; D015999:Multivariate Analysis; D011379:Prognosis; D012097:Repressor Proteins / Q000378:metabolism*; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000378:metabolism* / Q000473:pathology*; D051176:beta Catenin / Q000378:metabolism*
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D012097:Repressor Proteins; C485569:WIF1 protein, human; D051176:beta Catenin