title: Virus inactivation under the photodynamic effect of phthalocyanine zinc(II) complexes.
abstract: Various metal phthalocyanines have been studied for their capacity for photodynamic effects on viruses. Two newly synthesized water-soluble phthalocyanine Zn(II) complexes with different charges, cationic methylpyridyloxy-substituted Zn(II)- phthalocyanine (ZnPcMe) and anionic sulfophenoxy-substituted Zn(II)-phthalocyanine (ZnPcS), were used for photoinactivation of two DNA-containing enveloped viruses (herpes simplex virus type 1 and vaccinia virus), two RNA-containing enveloped viruses (bovine viral diarrhea virus and Newcastle disease virus) and two nude viruses (the enterovirus Coxsackie B1, a RNA-containing virus, and human adenovirus 5, a DNA virus). These two differently charged phthalocyanine complexes showed an identical marked virucidal effect against herpes simplex virus type 1, which was one and the same at an irradiation lasting 5 or 20 min (Δlog=3.0 and 4.0, respectively). Towards vaccinia virus this effect was lower, Δlog=1.8 under the effect of ZnPcMe and 2.0 for ZnPcS. Bovine viral diarrhea virus manifested a moderate sensitivity to ZnPcMe (Δlog=1.8) and a pronounced one to ZnPcS at 5- and 20-min irradiation (Δlog=5.8 and 5.3, respectively). The complexes were unable to inactivate Newcastle disease virus, Coxsackievirus B1 and human adenovirus type 5.
authors.affiliation: The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, Sofia, Bulgaria.
authors.forename: Mimi
authors.initials: M
authors.lastname: Remichkova
authors.affiliation: The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, Sofia, Bulgaria.
authors.forename: Luchia
authors.initials: L
authors.lastname: Mukova
authors.affiliation: The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, Sofia, Bulgaria.
authors.forename: Lubomira
authors.initials: L
authors.lastname: Nikolaeva-Glomb
authors.affiliation: The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, Sofia, Bulgaria.
authors.forename: Nadya
authors.initials: N
authors.lastname: Nikolova
authors.affiliation: The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, Sofia, Bulgaria.
authors.forename: Lubka
authors.initials: L
authors.lastname: Doumanova
authors.affiliation: Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Sofia, Bulgaria.
authors.forename: Vanya
authors.initials: V
authors.lastname: Mantareva
authors.affiliation: Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Sofia, Bulgaria.
authors.forename: Ivan
authors.initials: I
authors.lastname: Angelov
authors.affiliation: The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, Sofia, Bulgaria.
authors.forename: Veselin
authors.initials: V
authors.lastname: Kussovski
authors.affiliation: Department of Virology, The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, Acad. Georgi Bonchev Str. 26, 1113 Sofia, Bulgaria, Phone: +359-2-870-0108, Fax: +359-2-870-0109.
authors.forename: Angel S
authors.initials: AS
authors.lastname: Galabov
mesh_terms: D000260:Adenoviruses, Human / Q000187:drug effects / Q000254:growth & development / Q000528:radiation effects; D000838:Anions; D002412:Cations; D056831:Coordination Complexes / Q000138:chemical synthesis* / Q000494:pharmacology; D030241:Diarrhea Virus 1, Bovine Viral / Q000187:drug effects / Q000254:growth & development / Q000528:radiation effects; D029822:Enterovirus B, Human / Q000187:drug effects / Q000254:growth & development / Q000528:radiation effects; D018259:Herpesvirus 1, Human / Q000187:drug effects / Q000254:growth & development / Q000528:radiation effects; D007211:Indoles / Q000138:chemical synthesis* / Q000494:pharmacology; D054833:Isoindoles; D054023:Lasers, Semiconductor; D008027:Light; D009522:Newcastle disease virus / Q000187:drug effects / Q000254:growth & development / Q000528:radiation effects; D017319:Photosensitizing Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D011836:Radiation Tolerance / Q000502:physiology*; D013045:Species Specificity; D055672:Static Electricity; D014616:Vaccinia virus / Q000187:drug effects / Q000254:growth & development / Q000528:radiation effects; D038301:Virus Inactivation; D015032:Zinc / Q000737:chemistry*
chemical_list: D000838:Anions; D002412:Cations; D056831:Coordination Complexes; D007211:Indoles; D054833:Isoindoles; D017319:Photosensitizing Agents; D015032:Zinc; C013647:phthalocyanine