title: The Efficacy of Prophylactic Antibiotics on Post-Stroke Infections: An Updated Systematic Review and Meta-Analysis.
abstract: Post-stroke infections are common complications in acute stroke patients and are associated with an unfavorable functional outcome. However, reports on the effects of prophylactic antibiotics treatment on post-stroke infections are conflicting, especially those on post-stroke pneumonia and outcomes. We searched the PubMed, Embase, and Web of Knowledge databases up through March 11th, 2016. Seven randomized controlled trials including 4261 patients were analyzed among this systematic review and meta-analysis. We found preventive antibiotics treatment at the time of stroke onset did reduce the incidence of infections in adults with acute stroke (OR = 0.57, 95% CI: 0.38-0.85, P = 0.005), including reducing the number of urinary tract infections (OR = 0.34, 95% CI: 0.26-0.46, P < 0.001), but did not significantly decrease the rate of post-stroke pneumonia (OR = 0.91, 95% CI: 0.73-1.13, P = 0.385). Importantly, antibiotics treatment also showed no significant effect on the number of fatalities among stroke patients (OR = 1.07, 95% CI: 0.90-1.26, P = 0.743) and functional outcome scores on the modified Rankin Scale (OR = 1.76, 95% CI: 0.86-3.63, p = 0.124). Our study indicated that preventive antibiotics treatment not reduced the rate of post-stroke pneumonia or mortality, even though decreased the risk of infections, especially urinary tract infections. Thus, preventive antibiotics treatment may not be recommended for acute stroke patients.
authors.affiliation: Department of Neurology, Xinqiao Hospital, The Third Military Medical University, No. 183, Xinqiao Main street, Shapingba District, Chongqing 400037, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Liu
authors.affiliation: Department of Neurology, Xinqiao Hospital, The Third Military Medical University, No. 183, Xinqiao Main street, Shapingba District, Chongqing 400037, China.
authors.forename: Xiao-Yi
authors.initials: XY
authors.lastname: Xiong
authors.affiliation: Department of Neurology, Xinqiao Hospital, The Third Military Medical University, No. 183, Xinqiao Main street, Shapingba District, Chongqing 400037, China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Department of Developmental Neuropsychology, School of Psychology, Third Military Medical University, Chongqing 400037, China.
authors.forename: Xiao-Tang
authors.initials: XT
authors.lastname: Fan
authors.affiliation: Department of Neurology, Xinqiao Hospital, The Third Military Medical University, No. 183, Xinqiao Main street, Shapingba District, Chongqing 400037, China.
authors.forename: Qing-Wu
authors.initials: QW
authors.lastname: Yang
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D011014:Pneumonia / Q000209:etiology / Q000401:mortality / Q000517:prevention & control*; D016032:Randomized Controlled Trials as Topic; D020521:Stroke / Q000150:complications / Q000188:drug therapy* / Q000401:mortality; D014552:Urinary Tract Infections / Q000188:drug therapy / Q000401:mortality / Q000517:prevention & control*
chemical_list: D000900:Anti-Bacterial Agents