title: [Relationship between the level of maternal glycated hemoglobin and fetal hypertrophic cardiomyopathy].
abstract: BACKGROUND
  Diabetes mellitus is a metabolic disorder commonly associated with pregnancy. It is shown that as the management of diabetes during pregnancy is optimized, decreases the frequency and severity of fetal and neonatal complications. The aim of this paper is to identify the relation between the level of maternal glycated hemoglobin and fetal hypertrophic cardiomyopathy.
  
  
  METHODS
  An analitytic cross-sectional study was conducted. It included patients with single pregnancy of 28-37 weeks diagnosed with gestational or preconception diabetes mellitus. A fetal echocardiogram were performed, likewise measuring of glycated hemoglobin.
  
  
  RESULTS
  104 diabetic pregnant patients were included in the study, 83 patients in the group with normal glycated hemoglobin and 21 in the group with altered glycated hemoglobin. Of the 104 patients, 12 had fetal hypertrophic cardiomyopathy; 5 of the group with normal glycated hemoglobin and 7 with altered glycated hemoglobin. There is a clear association previously reported between the level maternal metabolic control and the presence of fetal and neonatal complications.
  
  
  CONCLUSIONS
  A positive correlation between the values of high maternal glycated hemoglobin and increased thickness of the fetal ventricular septum was observed. Fetal echocardiographic assessment is recommended for all pregnant women with gestational and pre-pregnancy diabetes mellitus in order to early detection of fetal hypertrophic cardiomyopathy.
authors.affiliation: Departamento de Medicina Fetal e Imagenología, Hospital de Ginecoobstetricia, Centro Médico Nacional de Occidente, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, México. popositos@hotmail.com.mx.
authors.forename: Karla Lucía
authors.initials: KL
authors.lastname: Sánchez-Martínez
authors.forename: Luis Fernando
authors.initials: LF
authors.lastname: Oseguera-Torres
authors.forename: Joel
authors.initials: J
authors.lastname: Ávalos-Nuño
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D002312:Cardiomyopathy, Hypertrophic / Q000000981:diagnostic imaging / Q000209:etiology*; D003430:Cross-Sectional Studies; D016640:Diabetes, Gestational / Q000097:blood*; D004452:Echocardiography; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism*; D006801:Humans; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000097:blood*; D012307:Risk Factors; D016216:Ultrasonography, Prenatal
chemical_list: D015415:Biomarkers; D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human
keywords: Diabetes mellitus; Gestational diabetes; Hypertrophic cardiomyopathy; Prediabetic state; Pregnancy