title: Validating Metal-Organic Framework Nanoparticles for Their Nanosafety in Diverse Biomedical Applications.
abstract: Metal-organic frameworks (MOFs) are promising platforms for the synthesis of nanoparticles for diverse medical applications. Their fundamental design principles allow for significant control of the framework architecture and pore chemistry, enabling directed functionalization for nanomedical applications. However, before applying novel nanomaterials to patients, it is imperative to understand their potential health risks. In this study, the nanosafety of different MOF nanoparticles is analyzed comprehensively for diverse medical applications. The authors first evaluate the effects of MOFs on human endothelial and mouse lung cells, which constitute a first line of defense upon systemic blood-mediated and local lung-specific applications of nanoparticles. Second, we validated these MOFs for multifunctional surface coatings of dental implants using human gingiva fibroblasts. Moreover, biocompatibility of MOFs is assessed for surface coating of nerve guidance tubes using human Schwann cells and rat dorsal root ganglion cultures. The main finding of this study is that the nanosafety and principal suitability of our MOF nanoparticles as novel agents for drug delivery and implant coatings strongly varies with the effector cell type. We conclude that it is therefore necessary to carefully evaluate the nanosafety of MOF nanomaterials with respect to their particular medical application and their interacting primary cell types, respectively.
authors.affiliation: Department of Chemistry and Center for NanoScience (CeNS), University of Munich (LMU), 81377, Munich, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Wuttke
authors.affiliation: Department of Chemistry and Center for NanoScience (CeNS), University of Munich (LMU), 81377, Munich, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Zimpel
authors.affiliation: Department of Chemistry and Center for NanoScience (CeNS), University of Munich (LMU), 81377, Munich, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Bein
authors.affiliation: Department of Pharmacy, University of Munich (LMU), 81377, Munich, Germany.
authors.forename: Simone
authors.initials: S
authors.lastname: Braig
authors.affiliation: Department of Pharmacy, University of Munich (LMU), 81377, Munich, Germany.
authors.forename: Katharina
authors.initials: K
authors.lastname: Stoiber
authors.affiliation: Department of Pharmacy, University of Munich (LMU), 81377, Munich, Germany.
authors.forename: Angelika
authors.initials: A
authors.lastname: Vollmar
authors.affiliation: Institute of Neuroanatomy, Hannover Medical School, Hannover, 30625, Germany.
authors.forename: Dominik
authors.initials: D
authors.lastname: Müller
authors.affiliation: Institute of Neuroanatomy, Hannover Medical School, Hannover, 30625, Germany.|Center for Systems Neurosciences (ZSN) Hannover, 30625, Hannover, Germany.
authors.forename: Kirsten
authors.initials: K
authors.lastname: Haastert-Talini
authors.affiliation: Department of Prosthetic Dentistry and Biomedical Materials Science, Hannover Medical School, Hannover, 30625, Germany.
authors.forename: Jörn
authors.initials: J
authors.lastname: Schaeske
authors.affiliation: Department of Prosthetic Dentistry and Biomedical Materials Science, Hannover Medical School, Hannover, 30625, Germany.
authors.forename: Meike
authors.initials: M
authors.lastname: Stiesch
authors.affiliation: Institute for Inorganic Chemistry, Leibniz University Hannover, Hannover, 30167, Germany.
authors.forename: Gesa
authors.initials: G
authors.lastname: Zahn
authors.affiliation: Institute for Inorganic Chemistry, Leibniz University Hannover, Hannover, 30167, Germany.
authors.forename: Alexander
authors.initials: A
authors.lastname: Mohmeyer
authors.affiliation: Institute for Inorganic Chemistry, Leibniz University Hannover, Hannover, 30167, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Behrens
authors.affiliation: Comprehensive Pneumology Center (CPC), University Hospital, University of Munich (LMU), Member of the German Center for Lung Research (DZL), 81377, Munich, Germany.
authors.forename: Oliver
authors.initials: O
authors.lastname: Eickelberg
authors.affiliation: Comprehensive Pneumology Center (CPC), University Hospital, University of Munich (LMU), Member of the German Center for Lung Research (DZL), 81377, Munich, Germany.
authors.forename: Deniz A
authors.initials: DA
authors.lastname: Bölükbas
authors.affiliation: Comprehensive Pneumology Center (CPC), University Hospital, University of Munich (LMU), Member of the German Center for Lung Research (DZL), 81377, Munich, Germany.
authors.forename: Silke
authors.initials: S
authors.lastname: Meiners
mesh_terms: D000818:Animals; D004337:Drug Carriers / Q000009:adverse effects / Q000737:chemistry*; D042783:Endothelial Cells / Q000166:cytology / Q000378:metabolism*; D005347:Fibroblasts / Q000166:cytology / Q000378:metabolism*; D005881:Gingiva / Q000166:cytology / Q000378:metabolism*; D006801:Humans; D051379:Mice; D053758:Nanoparticles / Q000009:adverse effects / Q000737:chemistry*
chemical_list: D004337:Drug Carriers
keywords: drug delivery; metal-organic frameworks; nanomedicine; nanoparticles; nanosafety