title: Altered Motor-Striatal Plasticity and Cortical Functioning in Patients with Schizophrenia.
abstract: Patients with schizophrenia undergo changes in brain plasticity. In the present study, we characterized motor cortical-striatal plasticity in such patients. Compared with the potentiation following high-frequency repetitive transcranial magnetic stimulation in the control group, the patients demonstrated impaired plasticity of corticostriatal motor-evoked potentials recorded from hand muscles. Notably, the loss of cortical plasticity was correlated with impaired motor learning in a rotary pursuit task. Moreover, the loss of plasticity was correlated with the symptoms of schizophrenia. The results suggest that the progression of schizophrenia is accompanied by altered cortical plasticity and functioning.
authors.affiliation: Ningbo Kangning Hospital, Ningbo Key Laboratory of Behavioral Neuroscience, Ningbo, 315201, China.
authors.forename: Dongsheng
authors.initials: D
authors.lastname: Zhou
authors.affiliation: School of Psychology, Nanjing Normal University, Nanjing, 210097, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Pang
authors.affiliation: Ningbo Kangning Hospital, Ningbo Key Laboratory of Behavioral Neuroscience, Ningbo, 315201, China.
authors.forename: Shiyan
authors.initials: S
authors.lastname: Liu
authors.affiliation: Rehabilitation Medicine Center, First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Shen
authors.affiliation: Ningbo Kangning Hospital, Ningbo Key Laboratory of Behavioral Neuroscience, Ningbo, 315201, China.
authors.forename: Lingjiang
authors.initials: L
authors.lastname: Liu
authors.affiliation: Ningbo Kangning Hospital, Ningbo Key Laboratory of Behavioral Neuroscience, Ningbo, 315201, China.
authors.forename: Zezhong
authors.initials: Z
authors.lastname: Fang
authors.affiliation: Ningbo Key Laboratory of Behavioral Neuroscience, Ningbo University School of Medicine, Ningbo, 315211, China. wangchuang@nbu.edu.cn.
authors.forename: Chuang
authors.initials: C
authors.lastname: Wang
authors.affiliation: Ningbo Kangning Hospital, Ningbo Key Laboratory of Behavioral Neuroscience, Ningbo, 315201, China. hzy86690952@163.com.
authors.forename: Zhenyu
authors.initials: Z
authors.lastname: Hu
authors.affiliation: School of Psychology, Nanjing Normal University, Nanjing, 210097, China. ytf0707@126.com.
authors.forename: Ti-Fei
authors.initials: TF
authors.lastname: Yuan
mesh_terms: D000293:Adolescent; D000328:Adult; D019054:Evoked Potentials, Motor / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009044:Motor Cortex / Q000503:physiopathology*; D017072:Neostriatum / Q000503:physiopathology*; D009473:Neuronal Plasticity / Q000502:physiology*; D011597:Psychomotor Performance / Q000502:physiology*; D012559:Schizophrenia / Q000503:physiopathology*; D050781:Transcranial Magnetic Stimulation / Q000379:methods*; D055815:Young Adult
keywords: Cortical plasticity; Motor learning; Schizophrenia; human