title: A promoter polymorphism in APJ gene is significantly associated with blood pressure changes and hypertension risk in Chinese women.
abstract: The aim of this study was to interrogate the gender-specific association of 5 well-defined polymorphisms in apelin/APJ system with both blood pressure changes and hypertension risk in a northeastern Chinese population. This is a population-based case-control study, including 650 hypertensive patients and 645 normotensive controls. Data were analyzed by STATA and Haplo.Stats. The genotype distributions of 5 study polymorphisms were in Hardy-Weinberg equilibrium in both genders. The rs7119375 and rs10501367 were completely linked. The genotypes (P = 0.001) and alleles (P < 0.001) of rs7119375 differed significantly between patients and controls in women. Carriers of rs7119375-AA genotype had significant higher systolic blood pressure (SBP) than carriers of rs7119375-GG genotype in both patients and controls of female gender (P < 0.01). Moreover, carriers of rs7119375-A allele were 1.80 times more likely to develop hypertension relative to carriers of rs7119375-GG genotype after adjusting for age, body mass index and glucose (odds ratio: 1.80; 95% confidence interval: 1.03-3.16; P= 0.040). Further allele combination analysis supported the leading contribution of rs7119375 to hypertension risk. Our findings demonstrated that the mutation of promoter polymorphism rs7119375 in APJ gene was significantly associated with elevated SBP and increased hypertension risk in Chinese women.
authors.affiliation: Department of Human Anatomy, School of Basic Medicine, Qiqihar Medical University, Qiqihar, Heilongjiang, China.
authors.forename: Guofeng
authors.initials: G
authors.lastname: Li
authors.affiliation: Department of Neurology, The Third Affiliated Hospital of Qiqihar Medical University, Qiqihar, Heilongjiang, China.
authors.forename: Xingyuan
authors.initials: X
authors.lastname: Sun
authors.affiliation: Clinical Laboratory, Qiqihar Jianhua Hospital, Qiqihar, Heilongjiang, China.
authors.forename: Dalong
authors.initials: D
authors.lastname: Zhao
authors.affiliation: Department of Advanced Mathematics, School of Basic Medicine, Qiqihar Medical University, Qiqihar, Heilongjiang, China.
authors.forename: Lan
authors.initials: L
authors.lastname: He
authors.affiliation: Department of Biogenetics, School of Basic Medicine, Qiqihar Medical University, Qiqihar, Heilongjiang, China.
authors.forename: Lihong
authors.initials: L
authors.lastname: Zheng
authors.affiliation: Department of Immunology, School of Medical Technolog, Qiqihar Medical University, Qiqihar, Heilongjiang, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Xue
authors.affiliation: Department of Physiology, School of Basic Medicine, Qiqihar Medical University, Qiqihar, Heilongjiang, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Wang
authors.affiliation: Department of Biochemistry, School of Basic Medicine, Qiqihar Medical University, Qiqihar, Heilongjiang, China.
authors.forename: Hongming
authors.initials: H
authors.lastname: Pan
mesh_terms: D000368:Aged; D000075244:Apelin Receptors / Q000235:genetics*; D044466:Asian People / Q000235:genetics*; D001794:Blood Pressure / Q000502:physiology*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000209:etiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic
chemical_list: C104575:APLNR protein, human; D000075244:Apelin Receptors
keywords: apelin/APJ system; association; blood pressure; essential hypertension; polymorphism