title: Ghost Cell Tumors.
abstract: Ghost cell tumors are a family of lesions that range in presentation from cyst to solid neoplasm and in behavior from benign to locally aggressive or metastatic. All are characterized by the presence of ameloblastic epithelium, ghost cells, and calcifications. This report presents the cases of a 14-year-old girl with a calcifying cystic odontogenic tumor (CCOT) and a 65-year-old woman with a peripheral dentinogenic ghost cell tumor (DGCT) with dysplastic changes, a rare locally invasive tumor of odontogenic epithelium. The first patient presented with a 1-year history of slowly progressing pain and swelling at the left body of the mandible. Initial panoramic radiograph displayed a mixed radiolucent and radiopaque lesion. An incisional biopsy yielded a diagnosis of CCOT. Decompression of the mass was completed; after 3 months, it was enucleated and immediately grafted with bone harvested from the anterior iliac crest. The second patient presented with a 3-month history of slowly progressing pain and swelling at the left body of the mandible. Initial panoramic radiograph depicted a mixed radiolucent and radiopaque lesion with saucerization of the buccal mandibular cortex. An incisional biopsy examination suggested a diagnosis of DGCT because of the presence of ghost cells, dentinoid, and islands of ameloblastic epithelium. Excision of the mass with peripheral ostectomy was completed. At 6 and 12 months of follow-up, no evidence of recurrence was noted.
authors.affiliation: Former Resident, Mount Sinai Medical Center, New York, NY; Fellow, Cleft and Craniomaxillofacial Surgery, Charleston Area Medical Center, Charleston, WV. Electronic address: jasonosheikh@gmail.com.
authors.forename: Jason
authors.initials: J
authors.lastname: Sheikh
authors.affiliation: Chief Resident, Department of Oral and Maxillofacial Pathology, Mount Sinai Medical Center, New York, NY.
authors.forename: Molly D
authors.initials: MD
authors.lastname: Cohen
authors.affiliation: Director, Oral and Maxillofacial Pathology Residency Program, Mount Sinai Medical Center, New York, NY.
authors.forename: Naomi
authors.initials: N
authors.lastname: Ramer
authors.affiliation: Attending, Department of Oral and Maxillofacial Surgery, Mount Sinai Medical Center, New York, NY.
authors.forename: Ali
authors.initials: A
authors.lastname: Payami
mesh_terms: D000293:Adolescent; D000368:Aged; D001706:Biopsy; D019299:Decompression, Surgical; D003937:Diagnosis, Differential; D018450:Disease Progression; D005260:Female; D006801:Humans; D008339:Mandibular Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D009361:Neoplasm Invasiveness; D018333:Odontogenic Cyst, Calcifying / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D011862:Radiography, Panoramic