title: Low-grade epilepsy-associated neuroepithelial tumours - the 2016 WHO classification.
abstract: Rapid developments in molecular genetic technology and research have swiftly advanced our understanding of neuro-oncology. As a consequence, the WHO invited their expert panels to revise the current classification system of brain tumours and to introduce, for the first time, a molecular genetic approach for selected tumour entities, thus setting a new gold standard in histopathology. The revised 5th edition of the 'blue book' was released in May 2016 and will have a major impact in stratifying diagnosis and treatment. However, low-grade neuroepithelial tumours that present with early-onset focal epilepsy and are mostly seen in children and young adults (previously designated as long-term epilepsy-associated neuroepithelial tumours, LEAT) lack such innovative clinicopathological and molecular genetic tools. The Neuropathology Task Force of the International League against Epilepsy will critically discuss this issue, and will offer perspectives on how to decipher and validate clinically meaningful LEAT entities using the current WHO approach that integrates clinicopathological and genetic classification systems.
authors.affiliation: Department of Neuropathology, University Hospital Erlangen, Schwabachanlage 6, D-91054 Erlangen, Germany.
authors.forename: Ingmar
authors.initials: I
authors.lastname: Blümcke
authors.affiliation: Department of NeuroPathology, Academic Medisch Centrum, Meibergdreef 9, 1105AZ Amsterdam, Netherlands.
authors.forename: Eleonora
authors.initials: E
authors.lastname: Aronica
authors.affiliation: Department of Neuropathology, University of Bonn Medical Centre, Sigmund-Freud Str. 25, D - 53105 Bonn, Germany.
authors.forename: Albert
authors.initials: A
authors.lastname: Becker
authors.affiliation: Department of Neuropathology, Institute of Pathology, Im Neuenheimer Feld 224, 69120 Heidelberg, Ruprecht-Karls-University Heidelberg, Heidelberg, Germany.
authors.forename: David
authors.initials: D
authors.lastname: Capper
authors.affiliation: Department of Neuropathology, University Hospital Erlangen, Schwabachanlage 6, D-91054 Erlangen, Germany.
authors.forename: Roland
authors.initials: R
authors.lastname: Coras
authors.affiliation: Department of Anatomic Pathology, Hospital Pedro Hispano, Rua Dr Eduardo Torres, 4460-504 Matosinhos, Portugal.
authors.forename: Mrinalini
authors.initials: M
authors.lastname: Honavar
authors.affiliation: Developmental Biology and Cancer Programme, UCL Great Ormond Street Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK.
authors.forename: Thomas S
authors.initials: TS
authors.lastname: Jacques
authors.affiliation: Department of Neuropathology, University Hospital Erlangen, Schwabachanlage 6, D-91054 Erlangen, Germany.
authors.forename: Katja
authors.initials: K
authors.lastname: Kobow
authors.affiliation: Department of Neuropathology, Research Institute for Brain and Blood Vessels - AKITA, 6-10 Senshu-Kubota-Machi, Akita City, Akita 010-0874, Japan.
authors.forename: Hajime
authors.initials: H
authors.lastname: Miyata
authors.affiliation: Department of NeuroPathology, Academic Medisch Centrum, Meibergdreef 9, 1105AZ Amsterdam, Netherlands.
authors.forename: Angelika
authors.initials: A
authors.lastname: Mühlebner
authors.affiliation: Laboratory of Neuropathology, Hospital de Santa Maria, (CHLN), Av. Prof. Egas Moniz, 1649-036, Lisbon, Portugal.
authors.forename: José
authors.initials: J
authors.lastname: Pimentel
authors.affiliation: Department of Pathology, Hacettepe University Faculty of Medicine, Sihhiye, Ankara, TR-06100 Turkey.
authors.forename: Figen
authors.initials: F
authors.lastname: Söylemezoğlu
authors.affiliation: Department of Neuropathology, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK.
authors.forename: Maria
authors.initials: M
authors.lastname: Thom
mesh_terms: D001932:Brain Neoplasms / Q000145:classification* / Q000150:complications* / Q000235:genetics / Q000473:pathology; D004827:Epilepsy / Q000209:etiology*; D006801:Humans; D018302:Neoplasms, Neuroepithelial / Q000145:classification* / Q000150:complications* / Q000235:genetics / Q000473:pathology; D014944:World Health Organization