title: The Effect of Salt-ProcessedPsoralea corylifoliaon Generative Organ Targeting.
abstract: Psoralen and isopsoralen are two isomers and main effective components withinPsoralea corylifolia. In order to investigate the salt-processing effect on tissue distribution characters of psoralen and isopsoralen, a sensitive and accurate ultrahigh pressure liquid chromatographic tandem mass spectrometric (UHPLC-MS/MS) method has been developed and validated for simultaneous determination of the 2 components in rats' tissues after administration of the extracts that came from either crude or salt-processedPsoralea corylifoliaL. Data displayed that both areas under the curve (AUC) of psoralen and isopsoralen from salt-processed scurfpea fruit group were significantly increased compared with that of the crude herb group, especially in heart (p< 0.05), ovary, and testes (p< 0.001). Though the RE and RCmaxof psoralen and isopsoralen in all of the investigated organs were over 1.0, generative organs kept the maximum value. The experiment manifested that salt-processing of scurfpea fruit can increase the distribution of psoralen and isopsoralen to generative organs, heart and spleen, and the distribution of psoralen and isopsoralen to generative organs is significantly higher compared to heart and spleen (p< 0.01). Results indicate that salt-processing of scurfpea fruit can significantly increase the distribution of psoralen and isopsoralen to generative organs.
authors.affiliation: College of Pharmacy, Nanjing University of Chinese Medicine, 138 Xianlin Avenue, Nanjing 210023, China.
authors.forename: Gen-Hua
authors.initials: GH
authors.lastname: Zhao
authors.affiliation: Jiangsu Jumpcan Pharmaceutical Group Co., Ltd., Taizhou 225441, China.
authors.forename: Cui-Ping
authors.initials: CP
authors.lastname: Yan
authors.affiliation: Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong.
authors.forename: Zi-Sheng
authors.identifier: 0000-0002-4242-4878
authors.initials: ZS
authors.lastname: Xu
authors.affiliation: College of Pharmacy, Nanjing University of Chinese Medicine, 138 Xianlin Avenue, Nanjing 210023, China.
authors.forename: Qian-Qian
authors.initials: QQ
authors.lastname: Gao
authors.affiliation: College of Pharmacy, Nanjing University of Chinese Medicine, 138 Xianlin Avenue, Nanjing 210023, China; Engineering Center of State Ministry of Education for Standardization of Chinese Medicine Processing, Nanjing University of Chinese Medicine, Nanjing 210023, China.
authors.forename: Zhi-Peng
authors.initials: ZP
authors.lastname: Chen
authors.affiliation: College of Pharmacy, Nanjing University of Chinese Medicine, 138 Xianlin Avenue, Nanjing 210023, China; Engineering Center of State Ministry of Education for Standardization of Chinese Medicine Processing, Nanjing University of Chinese Medicine, Nanjing 210023, China.
authors.forename: Wei-Dong
authors.identifier: 0000-0002-7664-1512
authors.initials: WD
authors.lastname: Li