title: Aptamers: novel diagnostic and therapeutic tools for diabetes mellitus and metabolic diseases.
abstract: Diabetes mellitus is one of the most common chronic diseases that threatens human health in worldwide populations. Despite enormous efforts invested in the study of diabetes mellitus, the development of precise diagnoses and treatments for this disease remains difficult due to the limitations of current techniques. Therefore, new methods are currently being developed. Aptamers are oligonucleotides that bind to specific target molecules and have been widely applied as diagnostic and therapeutic tools. In recent years, aptamers have been utilized in the study of diabetes mellitus and metabolic diseases. In this review, we highlight recent developments and new perspectives on aptamers in the field of diabetes mellitus and other metabolic diseases. Aptamers could potentially provide the means for efficient diagnoses and therapies against diabetes mellitus.
authors.affiliation: Department of Metabolism & Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China.|Key Laboratory of Diabetes Immunology (Central South University), Ministry of Education; National Clinical Research Center for Metabolic Diseases, Changsha, Hunan, 410011, China.
authors.forename: Jingping
authors.initials: J
authors.lastname: Hu
authors.affiliation: Molecular Science & Biomedicine Laboratory; State Key Laboratory of Chemo/Biosensing & Chemometrics, College of Chemistry & Chemical Engineering; College of Biology, Collaborative Innovation Center for Molecular Engineering for Theranostics, Hunan University, Changsha, Hunan, 410082, China.
authors.forename: Mao
authors.initials: M
authors.lastname: Ye
authors.affiliation: Department of Metabolism & Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China. zhouzg@hotmail.com.|Key Laboratory of Diabetes Immunology (Central South University), Ministry of Education; National Clinical Research Center for Metabolic Diseases, Changsha, Hunan, 410011, China. zhouzg@hotmail.com.
authors.forename: Zhiguang
authors.initials: Z
authors.lastname: Zhou
mesh_terms: D000818:Animals; D052157:Aptamers, Nucleotide / Q000032:analysis / Q000627:therapeutic use*; D003920:Diabetes Mellitus / Q000175:diagnosis* / Q000188:drug therapy*; D006801:Humans; D008659:Metabolic Diseases / Q000175:diagnosis* / Q000188:drug therapy*; D058990:Molecular Targeted Therapy / Q000379:methods; D052156:SELEX Aptamer Technique / Q000379:methods*
chemical_list: D052157:Aptamers, Nucleotide
keywords: Aptamers; Diabetes mellitus; Oligonucleotides