title: Assessment of systemic inflammatory response after total extraperitoneal repair and Lichtenstein repair for inguinal hernia.
abstract: The aim of the study was assessment of the systemic inflammatory response (SIR) intensity by measuring the blood serum levels of high sensitivity C-reactive protein (hsCRP), Interleukin-6 (IL-6) and Total Leukocyte Counts of patients. The estimations were done before and after the patient underwent either open Lichtenstein or endoscopic TEP inguinal hernia repair. This is a prospective observational type of study.
  
  
  
  Sixty patients with a diagnosis of unilateral uncomplicated inguinal hernia were included in the study. Patients were divided into two groups. In the first group, endoscopic total extraperitoneal repair (TEP) was done, while the other group underwent Lichtenstein repair. The patient selection was random. Serum markers for SIR were measured prior to and 24 h post-surgery.
  
  
  
  Total extraperitoneal repair (TEP) and open Lichtenstein inguinal hernia repair both cause a significant Systemic Inflammatory Response in the body. The rise in serum markers for SIR post-surgery was statistically significant in both the groups. The rise in serum hsCRP and IL-6 concentrations was observed to be equivocal among the two groups. Statistically significant difference was observed in serum TLC rise: Lichtenstein repair group having a higher value.
  
  
  
  Both, open and endoscopic surgical techniques incite a systemic inflammatory response in the body. However, it cannot be conclusively stated that TEP is associated with lesser SIR compared to the Lichtenstein repair on the basis of this study.
authors.affiliation: Department of Surgery, Lady Hardinge Medical College and Associated Smt. Sucheta Kriplani Hospital, C-702, Panchsheel Apartments, Plot No. 24, Sector 4, Dwarka, New Delhi, Delhi, 110078, India. vatsmanu@gmail.com.
authors.forename: M
authors.identifier: 0000-0001-7492-8475
authors.initials: M
authors.lastname: Vats
authors.affiliation: Department of Surgery, Lady Hardinge Medical College and Associated Smt. Sucheta Kriplani Hospital, C-604, Shaheed Bhagat Singh Road, Diz Area, Connaught Place, New Delhi, Delhi, 110001, India.
authors.forename: D
authors.initials: D
authors.lastname: Pandey
authors.affiliation: Department of Surgery, Lady Hardinge Medical College and Associated Smt. Sucheta Kriplani Hospital, C-604, Shaheed Bhagat Singh Road, Diz Area, Connaught Place, New Delhi, Delhi, 110001, India.
authors.forename: S
authors.initials: S
authors.lastname: Saha
authors.affiliation: Department of Surgery, Lady Hardinge Medical College and Associated Smt. Sucheta Kriplani Hospital, C-604, Shaheed Bhagat Singh Road, Diz Area, Connaught Place, New Delhi, Delhi, 110001, India.
authors.forename: N
authors.initials: N
authors.lastname: Talwar
authors.affiliation: Department of Surgery, Lady Hardinge Medical College and Associated Smt. Sucheta Kriplani Hospital, C-604, Shaheed Bhagat Singh Road, Diz Area, Connaught Place, New Delhi, Delhi, 110001, India.
authors.forename: G
authors.initials: G
authors.lastname: Saurabh
authors.affiliation: Department of Surgery, Lady Hardinge Medical College and Associated Smt. Sucheta Kriplani Hospital, C-604, Shaheed Bhagat Singh Road, Diz Area, Connaught Place, New Delhi, Delhi, 110001, India.
authors.forename: M
authors.initials: M
authors.lastname: Andley
authors.affiliation: Department of Surgery, Lady Hardinge Medical College and Associated Smt. Sucheta Kriplani Hospital, C-604, Shaheed Bhagat Singh Road, Diz Area, Connaught Place, New Delhi, Delhi, 110001, India.
authors.forename: A
authors.initials: A
authors.lastname: Kumar
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D055815:Young Adult; D002097:C-Reactive Protein / Q000032:analysis; D006552:Hernia, Inguinal / Q000601:surgery; D059685:Herniorrhaphy / Q000009:adverse effects / Q000379:methods; D015850:Interleukin-6 / Q000097:blood; D010535:Laparoscopy / Q000009:adverse effects; D007813:Laparotomy; D007958:Leukocyte Count; D010149:Postoperative Pain / Q000601:surgery; D010537:Peritoneum / Q000601:surgery; D011446:Prospective Studies; D013526:Surgical Mesh; D018746:Systemic Inflammatory Response Syndrome / Q000097:blood / Q000209:etiology / Q000276:immunology
chemical_list: D002097:C-Reactive Protein; C508600:IL6 protein, human; D015850:Interleukin-6
keywords: CRP; Endoscopy; Inguinal hernia; Interleukin-6; Systemic inflammatory response