title: Axon degeneration: Linking axonal bioenergetics to myelin.
abstract: The mechanisms by which axonal degeneration occurs, even in the presence of apparently normal myelin sheaths, remain unknown. In this issue, Yin et al. (2016. J. Cell Biol. https://doi.org/10.1083/jcb.201607099) study mutant mice in which proteolipid protein is replaced by the peripheral myelin protein P0and describe a number of early axonal abnormalities, which together suggest that aberrant mitochondrial energy metabolism precedes axonal degeneration.
authors.affiliation: Hunter James Kelly Research Institute, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY 14203.
authors.forename: Bogdan
authors.initials: B
authors.lastname: Beirowski
authors.affiliation: Hunter James Kelly Research Institute, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY 14203.
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Babetto
authors.affiliation: Hunter James Kelly Research Institute, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY 14203 bogdanbe@buffalo.edu lwrabetz@buffalo.edu.
authors.forename: Lawrence
authors.initials: L
authors.lastname: Wrabetz
mesh_terms: D000818:Animals; D001370:Axonal Transport; D001369:Axons / Q000378:metabolism*; D004734:Energy Metabolism; D008817:Mice, Mutant Strains; D008928:Mitochondria / Q000378:metabolism; D063154:Mitochondrial Dynamics; D008954:Models, Biological; D009186:Myelin Sheath / Q000378:metabolism*; D009410:Nerve Degeneration / Q000378:metabolism*; D009836:Oligodendroglia / Q000378:metabolism