title: Early Complications After Percutaneous Closure of Atrial Septal Defect in Infants with Procedural Weight Less than 15 kg.
abstract: Atrial septal defect (ASD) is the most common congenital cardiac lesion accounting for 10-15% of all cardiac malformations. In the majority of cases, the secundum type of the ASD is closed percutaneously in the catheterization laboratory. Although transcatheter closure of ASD is considered safe and effective in pediatric patients, there are limited data regarding the efficacy and safety of device ASD closure in smaller infants. The aim of this study was to determine risk of complications within 72 h following device closure of ASD in children of body weight <15 kg compared to larger children. Overall 252 children who underwent transcatheter closure of ASD at Children's Heart Centre in Lund, Sweden, between 1998 and 2015 were included. Data regarding demographics, comorbidity and complications occurring during and after device procedure until discharge were retrieved from the hospital's databases. Echocardiographic data were obtained from the digital and videotape recordings. Nearly half of the study cohort (n = 112; 44%) had a procedural weight <15 (median 11.3) kg with a median procedural age of 2.02 years. Among this study group, 22 (9%) children had post-procedural in-hospital complications, of which 16 (7%) were considered as major and six (2%) considered as minor. No deaths occurred. There was no significant difference in of the occurrence of major or minor complications between the two groups (p = 0.32). Larger ASD was more often associated with minor complications, OR 1.37 (95% CI 0.99-1.89), which most often consisted of transient arrhythmias during or after the procedure. Percutaneous ASD device closure can be performed safely in low-weight infants with a risk of post-procedural in-hospital complications comparable to larger/older children. Nevertheless, careful considerations of the indications to device closure is needed, particularly in children with larger ASD, as recommended by the current international guidelines for ASD closure.
authors.affiliation: Department of Clinical Science Paediatrics, Umeå University, Umeå, Sweden. gustaf.tanghoj@regionjh.se.|Unit of Research Education and Development, Östersund Hospital, Östersund, Sweden. gustaf.tanghoj@regionjh.se.
authors.forename: Gustaf
authors.identifier: http://orcid.org/0000-0002-8785-3318
authors.initials: G
authors.lastname: Tanghöj
authors.affiliation: Department of Cardiology, Pediatric Heart Center, Skåne University Hospital Lund, Lund University, Lund, Sweden.|Department of Paediatrics, Blekinge Hospital, Karlskrona, Sweden.
authors.forename: Michal
authors.initials: M
authors.lastname: Odermarsky
authors.affiliation: Department of Clinical Science Paediatrics, Umeå University, Umeå, Sweden.|Unit of Research Education and Development, Östersund Hospital, Östersund, Sweden.
authors.forename: Estelle
authors.initials: E
authors.lastname: Naumburg
authors.affiliation: Department of Cardiology, Pediatric Heart Center, Skåne University Hospital Lund, Lund University, Lund, Sweden.
authors.forename: Petru
authors.initials: P
authors.lastname: Liuba
mesh_terms: D000293:Adolescent; D001145:Arrhythmias, Cardiac / Q000209:etiology*; D001835:Body Weight; D006328:Cardiac Catheterization / Q000009:adverse effects / Q000379:methods*; D002648:Child; D002675:Child, Preschool; D015897:Comorbidity; D017548:Echocardiography, Transesophageal; D005260:Female; D005500:Follow-Up Studies; D006344:Heart Septal Defects, Atrial / Q000150:complications* / Q000601:surgery; D006801:Humans; D007223:Infant; D016015:Logistic Models; D011183:Postoperative Complications / Q000453:epidemiology*; D012189:Retrospective Studies; D012307:Risk Factors; D055989:Septal Occluder Device / Q000009:adverse effects*; D013548:Sweden; D016896:Treatment Outcome
keywords: Atrial septal defect; Follow-up; Infant; Post-interventional complications; Septal device