title: [Study of Medullary Thyroid Carcinoma from a proband].
abstract: Thyroid cancer is an uncommon type of cancer, accounting less than 1% of all cancers in adults, and 0.5-3% of all cancers in children. There are four different types: papillary carcinoma (80-90% of cases), follicular (5-10%), medullary (5%) and anaplastic cell (2-3%). Eighty per cent of cases of medullary thyroid cancer are sporadic, but 20% are associated with an inherited syndrome that is divided into three groups: multiple endocrine neoplasia type 1, multiple endocrine neoplasia type 2 and familial medullary thyroid carcinoma. The inherited forms are caused by a disruption in the RET oncogene, which is located in the long arm of chromosome 10. A hereditary case of medullary thyroid carcinoma is presented. It was detected because of a familial genetic study. The purpose of the paper is emphasize the importance of the early diagnosis and the intervention of multidisciplinary teams of experts.
authors.affiliation: Hospital Universitario Miguel Servet, Servicio de Endocrinología Pediátrica, Zaragoza, España.
authors.forename: Laura
authors.initials: L
authors.lastname: Morlán Herrador
authors.affiliation: Hospital Universitario Miguel Servet, Servicio de Endocrinología Pediátrica, Zaragoza, España. adearriba@salud.aragon.es.
authors.forename: Antonio
authors.initials: A
authors.lastname: de Arriba
authors.affiliation: Hospital Universitario Miguel Servet, Servicio de Endocrinología Pediátrica, Zaragoza, España.
authors.forename: Gloria
authors.initials: G
authors.lastname: Miguel
authors.affiliation: Hospital Universitario Miguel Servet, Servicio de Endocrinología Pediátrica, Zaragoza, España.
authors.forename: Marta
authors.initials: M
authors.lastname: Ferrera
authors.affiliation: Hospital Universitario Miguel Servet, Servicio de Endocrinología Pediátrica, Zaragoza, España.
authors.forename: José I
authors.initials: JI
authors.lastname: Labarta
mesh_terms: D018278:Carcinoma, Neuroendocrine / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D002675:Child, Preschool; D005260:Female; D006801:Humans; D010375:Pedigree; D013964:Thyroid Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy
keywords: Early diagnosis; Genetic techniques; Interdisciplinary health team; Medullary thyroid cancer