title: Indications for antiviral therapy for chronic hepatitis B in pregnant mothers.
abstract: The use of antiviral therapy for chronic hepatitis B virus (HBV) infection in the setting of pregnancy needs to be individualised based on limited data. We report a case of a 34-year-old Korean-American woman with a history of pregnancy with emergent caesarean section due to prolonged labour in the setting of HBV e-antigen (HBeAg) positive chronic HBV with a pretreatment baseline HBV DNA level of 110000 000 million copies per mL. Her first delivery was complicated by mother-to-child transmission (MTCT) of HBV infection to her daughter despite standard active and passive immunoprophylaxis. Our case report highlights an important clinical decision-making step regarding the timing of antiviral therapy in the management of chronic HBV in pregnant women with high risk of MTCT.
authors.affiliation: Department of Medicine, University of Illinois at Chicago College of Medicine, Chicago, Illinois, USA.
authors.forename: Eric Raeyoon
authors.initials: ER
authors.lastname: Yoo
authors.affiliation: Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Palo Alto, California, USA.
authors.forename: Ryan Babu
authors.initials: RB
authors.lastname: Perumpail
authors.affiliation: Division of Gastroenterology and Hepatology, University of Tennessee Health Science Center College of Medicine, Memphis, Tennessee, USA.
authors.forename: George
authors.initials: G
authors.lastname: Cholankeril
authors.affiliation: Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Palo Alto, California, USA.
authors.forename: Aijaz
authors.identifier: http://orcid.org/0000-0002-3609-8586
authors.initials: A
authors.lastname: Ahmed
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use*; D002585:Cesarean Section; D004279:DNA, Viral; D003657:Decision Making; D005260:Female; D006514:Hepatitis B Surface Antigens; D006513:Hepatitis B e Antigens; D006515:Hepatitis B virus; D019694:Hepatitis B, Chronic / Q000150:complications / Q000188:drug therapy* / Q000821:virology; D006801:Humans; D007116:Immunization, Passive; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy* / Q000821:virology
chemical_list: D000998:Antiviral Agents; D004279:DNA, Viral; D006514:Hepatitis B Surface Antigens; D006513:Hepatitis B e Antigens