title: Adipose tissue macrophage in immune regulation of metabolism.
abstract: The prevalence of obesity and type 2 diabetes is escalating to an epidemic proportion worldwide. Obesity is known to be associated with a state of chronic, low-grade inflammation. Emerging lines of evidence have shown that both innate and adaptive immune responses play crucial roles in the control of metabolic homeostasis. Macrophages in adipose tissues are the essential effector cells in orchestrating metabolic inflammation, which is thought to promote the pathogenic progression of obesity and obesity-related disorders. Here we discuss our current understanding of the distinct modes of activation of adipose tissue macrophages, which can sense the metabolic cues and exert profound effects upon adipose homeostasis. Targeting macrophages in adipose tissues may provide new avenues for developing immunomodulation-based therapeutics against obesity and obesity-associated metabolic diseases.
authors.affiliation: Institute of Molecular Medicine, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, 100871, China. yifu.qiu@pku.edu.cn.
authors.forename: Yifu
authors.initials: Y
authors.lastname: Qiu
authors.affiliation: Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences; University of the Chinese Academy of Sciences, Shanghai, 200031, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Shan
authors.affiliation: Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences; University of the Chinese Academy of Sciences, Shanghai, 200031, China.
authors.forename: Liu
authors.initials: L
authors.lastname: Yang
authors.affiliation: Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, the Institute for Advanced Studies, Wuhan University, Wuhan, 430072, China. liuyong31279@whu.edu.cn.
authors.forename: Yong
authors.initials: Y
authors.lastname: Liu
mesh_terms: D017667:Adipocytes / Q000276:immunology; D000273:Adipose Tissue / Q000276:immunology* / Q000378:metabolism; D000818:Animals; D006706:Homeostasis / Q000276:immunology*; D006801:Humans; D007249:Inflammation / Q000276:immunology* / Q000378:metabolism; D008262:Macrophage Activation / Q000276:immunology; D008264:Macrophages / Q000276:immunology*; D018448:Models, Immunological; D009765:Obesity / Q000276:immunology / Q000378:metabolism
keywords: adipose tissue; inflammation; macrophage; metabolic disease; obesity