title: The Association between Alcohol Consumption and β-Cell Function and Insulin Sensitivity in Korean Population.
abstract: This cross-sectional study was performed to examine the association between alcohol consumption and insulin secretion and sensitivity using the Korean Genome and Epidemiology Study. Alcohol consumption levels were categorized into four groups: (i) abstainers, (ii) low (<5 g/day), (iii) intermediate (<30 g/day), and (iv) high (≥30 g/day) alcohol consumption. β-cell function and insulin sensitivity were estimated using the insulinogenic index (IGI60), and Matsuda insulin sensitivity index (ISI), respectively. IGI60and ISI were dichotomized into high and low groups using median cut-off values and four groups were defined (G-I: high IGI60/high ISI; G-II: high IGI60/low ISI; G-III: low IGI60/high ISI; and G-IV: low IGI60/low ISI). Men consumed 26.5 g alcohol per day on average, whereas women only consumed 5.7 g/day, so women were excluded from subsequent analyses due to their low drinking levels. Alcohol consumption was positively associated with high-density lipoprotein (HDL) cholesterol, aspartate aminotransferase (AST), and triglycerides (TG) in men, but was negatively associated with IGI60(p< 0.05). TG levels were only increased in individuals with decreased insulin sensitivity (G-II) or decreased β-cell function (G-III) with high alcohol consumption. In addition, alcohol consumption increased HDL cholesterol in the four groups (p< 0.001). In subjects with decreased insulin sensitivity (G-II), intermediate and high alcohol consumption increased the risk of high cholesterol and TG. In individuals with decreased β-cell function (G-III), alcohol consumption increased the risk of high TG and high AST levels. High alcohol consumption was significantly associated with reduced insulin secretion. In addition, alcohol consumption was related to some metabolic risk factors depending on insulin secretion or sensitivity.
authors.affiliation: Center for Biomedical Sciences, Korea National Institute of Health, Cheongju 28159, Korea. yoomingku@korea.kr.
authors.forename: Min-Gyu
authors.initials: MG
authors.lastname: Yoo
authors.affiliation: Center for Biomedical Sciences, Korea National Institute of Health, Cheongju 28159, Korea. yo2412@korea.kr.
authors.forename: Hyo-Jin
authors.initials: HJ
authors.lastname: Kim
authors.affiliation: Center for Biomedical Sciences, Korea National Institute of Health, Cheongju 28159, Korea. greatstar@korea.kr.
authors.forename: Han Byul
authors.initials: HB
authors.lastname: Jang
authors.affiliation: Center for Biomedical Sciences, Korea National Institute of Health, Cheongju 28159, Korea. hyejalee@korea.kr.
authors.forename: Hye-Ja
authors.initials: HJ
authors.lastname: Lee
authors.affiliation: Center for Biomedical Sciences, Korea National Institute of Health, Cheongju 28159, Korea. parksi@nih.go.kr.
authors.forename: Sang Ick
authors.initials: SI
authors.lastname: Park
mesh_terms: D000328:Adult; D000368:Aged; D000428:Alcohol Drinking / Q000009:adverse effects* / Q000503:physiopathology; D015415:Biomarkers / Q000378:metabolism; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism; D005260:Female; D006801:Humans; D007328:Insulin / Q000378:metabolism; D007333:Insulin Resistance; D050417:Insulin-Secreting Cells / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D056910:Republic of Korea; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D007328:Insulin
keywords: alcohol consumption; hypertriglyceridemia; insulin sensitivity; β-cell function