title: N-[11CH3]Dimethylaminoparthenolide (DMAPT) uptake into orthotopic 9LSF glioblastoma tumors in the rat.
abstract: The aim of this study was to determine the uptake of intravenously administered N-[11CH3]-dimethylaminoparthenolide (DMAPT) into orthotopic 9LSF glioblastoma brain tumors in Fisher 344 rats from positron emission tomography (PET) imaging studies. [11C]methyl iodide (11CH3I) was utilized as a [11C]-labeling reagent to label the precursor methylaminoparthenolide (MAPT) intermediate. From PET imaging studies it was found that brain uptake of N-[11CH3]DMAPT into brain tumor tissue was rapid (30min), and considerably higher than that in the normal brain tissue.
authors.affiliation: Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, AR 72205-7199, USA.
authors.forename: Narsimha Reddy
authors.initials: NR
authors.lastname: Penthala
authors.affiliation: Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, AR 72205-7199, USA.
authors.forename: Venumadhav
authors.initials: V
authors.lastname: Janganati
authors.affiliation: College of Medicine, Department of Radiology, University of Arkansas for Medical Sciences, Little Rock, AR 72205-7199, USA.
authors.forename: Terri L
authors.initials: TL
authors.lastname: Alpe
authors.affiliation: 3D Imaging, LLC, Maumelle, AR 72113, USA.
authors.forename: Scott M
authors.initials: SM
authors.lastname: Apana
authors.affiliation: 3D Imaging, LLC, Maumelle, AR 72113, USA.
authors.forename: Marc S
authors.initials: MS
authors.lastname: Berridge
authors.affiliation: Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, AR 72205-7199, USA. Electronic address: pacrooks@uams.edu.
authors.forename: Peter A
authors.initials: PA
authors.lastname: Crooks
authors.affiliation: Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, AR 72205-7199, USA; College of Medicine, Department of Radiology, University of Arkansas for Medical Sciences, Little Rock, AR 72205-7199, USA. Electronic address: MJBorrelli@uams.edu.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Borrelli
mesh_terms: D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005909:Glioblastoma / Q000000981:diagnostic imaging* / Q000473:pathology; D015394:Molecular Structure; D049268:Positron-Emission Tomography; D051381:Rats; D011916:Rats, Inbred F344; D012717:Sesquiterpenes / Q000737:chemistry / Q000493:pharmacokinetics*; D013329:Structure-Activity Relationship
chemical_list: C524858:LC-1 compound; D012717:Sesquiterpenes
keywords: Dimethylaminoparthenolide (DMAPT); PET-imaging; Uptake into brain; [(11)C]-labeled DMAPT