title: Efficient DBU accelerated synthesis of18F-labelled trifluoroacetamides.
abstract: Nucleophilic18F-fluorination of bromodifluoromethyl derivatives was performed using [18F]Bu4NF in the presence of DBU (1,8-diazabicyclo[5.4.0]undec-7-ene). This novel procedure provided a diverse set of [18F]trifluoroacetamides in good to excellent radiochemical conversions. A mechanism where DBU acts as organomediator in this transformation is proposed.
authors.affiliation: AstraZeneca Personalised Healthcare and Biomarkers, PET Centre at Karolinska Institutet, Karolinska Universitetssjukhuset Solna, R5:02, SE-171 76 Stockholm, Sweden. Magnus.Schou@astrazeneca.com and Department of Organic Chemistry, Stockholm University, Arrhenius Laboratory, SE-106 91 Stockholm, Sweden and Stockholm Brain Institute, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
authors.forename: Antonio Bermejo
authors.identifier: http://orcid.org/0000-0002-1333-7740
authors.initials: AB
authors.lastname: Gómez
authors.affiliation: Department of Organic Chemistry, Stockholm University, Arrhenius Laboratory, SE-106 91 Stockholm, Sweden and Stockholm Brain Institute, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
authors.forename: Miguel A
authors.identifier: http://orcid.org/0000-0003-4299-8860
authors.initials: MA
authors.lastname: Cortés González
authors.affiliation: Department of Organic Chemistry, Stockholm University, Arrhenius Laboratory, SE-106 91 Stockholm, Sweden and Stockholm Brain Institute, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
authors.forename: Marvin
authors.initials: M
authors.lastname: Lübcke
authors.affiliation: CVMD iMed, Medicinal Chemistry AstraZeneca R&D, Mölndal, SE-431 83, Sweden.
authors.forename: Magnus J
authors.initials: MJ
authors.lastname: Johansson
authors.affiliation: Stockholm Brain Institute, Karolinska Institutet, SE-171 77 Stockholm, Sweden and Department of Clinical Neuroscience, Karolinska Institutet, S-17176 Stockholm, Sweden.
authors.forename: Christer
authors.initials: C
authors.lastname: Halldin
authors.affiliation: Department of Organic Chemistry, Stockholm University, Arrhenius Laboratory, SE-106 91 Stockholm, Sweden and Stockholm Brain Institute, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
authors.forename: Kálmán J
authors.initials: KJ
authors.lastname: Szabó
authors.affiliation: AstraZeneca Personalised Healthcare and Biomarkers, PET Centre at Karolinska Institutet, Karolinska Universitetssjukhuset Solna, R5:02, SE-171 76 Stockholm, Sweden. Magnus.Schou@astrazeneca.com and Stockholm Brain Institute, Karolinska Institutet, SE-171 77 Stockholm, Sweden and Department of Clinical Neuroscience, Karolinska Institutet, S-17176 Stockholm, Sweden.
authors.forename: Magnus
authors.initials: M
authors.lastname: Schou