title: Effects of a Novel Nutritional Formula Enriched With Eicosapentaenoic Acid and Docosahexaenoic Acid Specially Developed for Tube-Fed Hemodialysis Patients.
abstract: To evaluate the effects of a nutritional formula enriched with eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in tube-fed bedridden hemodialysis patients.
  
  
  
  A prospective, multicenter, single-arm study.
  
  
  
  Koyukai Memorial Hospital, Orimoto Hospital, and Chofu Hospital, Japan.
  
  
  
  Eleven tube-fed bedridden hemodialysis patients.
  
  
  
  Patients were fed a nutritional formula enriched with EPA and DHA for 12 weeks.
  
  
  
  Body weight; body mass index (BMI); serum levels of total protein, albumin, prealbumin, total cholesterol, triglyceride, and C-reactive protein (CRP); serum fatty acid composition.
  
  
  
  Body weight; BMI; and serum levels of total protein, albumin, total cholesterol, triglyceride, and CRP at 12 weeks were not significantly different from baseline levels. Serum prealbumin, EPA, and DHA levels significantly increased after 12 weeks of treatment.
  
  
  
  A nutritional formula enriched with EPA and DHA may be beneficial for nutritional management in tube-fed bedridden hemodialysis patients.
authors.affiliation: Koyukai Memorial Hospital, Chiba, Japan.
authors.forename: Shinga
authors.initials: S
authors.lastname: Esaki
authors.affiliation: Koyukai Memorial Hospital, Chiba, Japan.
authors.forename: Motokazu-Tohru
authors.initials: MT
authors.lastname: Iwahori
authors.affiliation: Orimoto Hospital, Kiyose, Japan.
authors.forename: Yuri
authors.initials: Y
authors.lastname: Takagi
authors.affiliation: Hemodialysis Unit, Chofu Hospital, Tokyo, Japan; Department of Nephrology, Tokyo Medical University, Tokyo, Japan.
authors.forename: Toshikazu
authors.initials: T
authors.lastname: Wada
authors.affiliation: Wellness & Nutrition Science Institute, R&D Division, Morinaga Milk Industry Co., Ltd., Zama, Japan.
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Morita
authors.affiliation: Wellness & Nutrition Science Institute, R&D Division, Morinaga Milk Industry Co., Ltd., Zama, Japan.
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Sonoki
authors.affiliation: Organization for Kidney and Metabolic Disease Treatment, Tokyo, Japan. Electronic address: t-nakao@tokyo-med.ac.jp.
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Nakao
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D001835:Body Weight; D002097:C-Reactive Protein / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D004032:Diet; D004281:Docosahexaenoic Acids / Q000008:administration & dosage* / Q000097:blood; D015118:Eicosapentaenoic Acid / Q000008:administration & dosage* / Q000097:blood; D004750:Enteral Nutrition; D005260:Female; D005526:Food, Formulated / Q000032:analysis*; D006801:Humans; D007564:Japan; D008297:Male; D009753:Nutritive Value; D011446:Prospective Studies; D006435:Renal Dialysis; D012709:Serum Albumin / Q000378:metabolism; D016896:Treatment Outcome; D014280:Triglycerides / Q000097:blood
chemical_list: D012709:Serum Albumin; D014280:Triglycerides; D004281:Docosahexaenoic Acids; D002097:C-Reactive Protein; D002784:Cholesterol; D015118:Eicosapentaenoic Acid