title: [Association of single nucleotide polymorphism in exon of transient receptor potential melastatin 2 gene with sepsis].
abstract: Objective:To investigate the association between single nucleotide polymorphism (SNP) in the 11th exon of transient receptor potential melastatin 2 (TRPM2) gene with the susceptibility and outcome of sepsis.Methods:A total of 119 septic patients and 112 normal subjects were enrolled from the First Affiliated Hospital, Zhejiang University School of Medicine. Among 119 septic patients, 62 died (fatal group) and 57 survived (survival group) within 28 days of disease onset. The genotypes of these individuals were detected using TaqMan allelic discrimination assays, and its correlations with susceptibility and outcome of sepsis were analyzed.Results:There was no significant difference in genotype frequencies and allelic frequencies of TRPM2 SNP rs1556314 between septic patients and the controls (allP>0.05). And no significant difference in genotype frequencies and allelic frequencies of TRPM2 SNP rs1556314 was observed between the survivors and fatal cases of septic patients (allP>0.05).Conclusion:The TRPM2 SNP rs1556314 does not have significant association with sepsis, but this result need to be confirmed by large scale studies.
authors.affiliation: Department of Anesthesiology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China;Department of Anesthesiology, Ningbo Medical Treatment Center Lihuili Hospital, Ningbo 315000, China.
authors.forename: Minbo
authors.initials: M
authors.lastname: Fang
authors.affiliation: Clinical Research Center, the Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310052, China.
authors.forename: Qixing
authors.initials: Q
authors.lastname: Chen
authors.affiliation: Department of Anesthesiology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
authors.forename: Shuijing
authors.initials: S
authors.lastname: Wu
authors.affiliation: Department of Anesthesiology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China. xiangming_fang@163.com.
authors.forename: Xiangming
authors.initials: X
authors.lastname: Fang
mesh_terms: D005091:Exons / Q000235:genetics / Q000502:physiology; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics / Q000502:physiology; D018805:Sepsis / Q000235:genetics* / Q000401:mortality; D050053:TRPM Cation Channels / Q000235:genetics*
chemical_list: D050053:TRPM Cation Channels; C121934:TRPM2 protein, human