title: Disrupted Topological Patterns of Large-Scale Network in Conduct Disorder.
abstract: Regional abnormalities in brain structure and function, as well as disrupted connectivity, have been found repeatedly in adolescents with conduct disorder (CD). Yet, the large-scale brain topology associated with CD is not well characterized, and little is known about the systematic neural mechanisms of CD. We employed graphic theory to investigate systematically the structural connectivity derived from cortical thickness correlation in a group of patients with CD (N = 43) and healthy controls (HCs, N = 73). Nonparametric permutation tests were applied for between-group comparisons of graphical metrics. Compared with HCs, network measures including global/local efficiency and modularity all pointed to hypo-functioning in CD, despite of preserved small-world organization in both groups. The hubs distribution is only partially overlapped with each other. These results indicate that CD is accompanied by both impaired integration and segregation patterns of brain networks, and the distribution of highly connected neural network 'hubs' is also distinct between groups. Such misconfiguration extends our understanding regarding how structural neural network disruptions may underlie behavioral disturbances in adolescents with CD, and potentially, implicates an aberrant cytoarchitectonic profiles in the brain of CD patients.
authors.affiliation: Medical Psychological Institute, the Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
authors.forename: Yali
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: School of Biomedical Engineering, Health Science Centre, Shenzhen University, Shenzhen, Guangdong, People's Republic of China.|Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, Shenzhen University, Shenzhen, Guangdong, People's Republic of China.
authors.forename: Weixiang
authors.initials: W
authors.lastname: Liu
authors.affiliation: Medical Psychological Institute, the Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
authors.forename: Qingsen
authors.initials: Q
authors.lastname: Ming
authors.affiliation: Medical Psychological Institute, the Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
authors.forename: Yidian
authors.initials: Y
authors.lastname: Gao
authors.affiliation: Medical Psychological Institute, the Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
authors.forename: Ren
authors.initials: R
authors.lastname: Ma
authors.affiliation: Medical Psychological Institute, the Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
authors.forename: Xiaocui
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Radiology, the Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
authors.forename: Weijun
authors.initials: W
authors.lastname: Situ
authors.affiliation: Medical Psychological Institute, the Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.|National Technology Institute of Psychiatry, Central South University, Changsha, Hunan, People's Republic of China.|Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha, Hunan, People's Republic of China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Wang
authors.affiliation: Medical Psychological Institute, the Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.|National Technology Institute of Psychiatry, Central South University, Changsha, Hunan, People's Republic of China.|Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha, Hunan, People's Republic of China.
authors.forename: Shuqiao
authors.initials: S
authors.lastname: Yao
authors.affiliation: Medical Psychological Institute, the Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.|Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, Shenzhen University, Shenzhen, Guangdong, People's Republic of China.|Shenzhen Institute of Research and Innovation, University of Hong Kong, Shenzhen, Guangdong, People's Republic of China.
authors.forename: Bingsheng
authors.initials: B
authors.lastname: Huang
mesh_terms: D019955:Conduct Disorder / Q000473:pathology / Q000503:physiopathology; D063132:Connectome; D005260:Female; D006801:Humans; D008297:Male; D008568:Memory; D009415:Nerve Net / Q000473:pathology / Q000503:physiopathology