title: [Improving adverse drug reaction reporting by general practitioners through clinical research assistants visits].
abstract: The main limitation of adverse drug reactions (ADRs) reporting, particularly by general practitioners (GP), to the regional pharmacovigilance centers is under-reporting. The Midi-Pyrénées Regional Pharmacovigilance Center (South western, France) sets up regular visits by a clinical research assistant (CRA) to GP in order to increase the number of ADR reports. The aim of this pilot study was to assess the effect of regular visits of a CRA in GPs offices on the rate of ADR reporting. After one year, CRA visits permit a two-fold increase in ADR reporting.
authors.affiliation: Service de pharmacologie médicale et clinique, centre Midi-Pyrénées de pharmacovigilance, pharmacoépidémiologie et informations sur le médicament, pharmacopôle Midi-Pyrénées, faculté de médecine, CHU de Toulouse, 37, allées Jules-Guesde, 31000 Toulouse, France. Electronic address: genevieve.durrieu@univ-tlse3.fr.
authors.forename: Geneviève
authors.initials: G
authors.lastname: Durrieu
authors.affiliation: Service de pharmacologie médicale et clinique, centre Midi-Pyrénées de pharmacovigilance, pharmacoépidémiologie et informations sur le médicament, pharmacopôle Midi-Pyrénées, faculté de médecine, CHU de Toulouse, 37, allées Jules-Guesde, 31000 Toulouse, France.
authors.forename: Julien
authors.initials: J
authors.lastname: Jacquot
authors.affiliation: Agence régionale de santé Midi-Pyrénées, 31000 Toulouse, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Baudrin
authors.affiliation: Service de pharmacologie médicale et clinique, centre Midi-Pyrénées de pharmacovigilance, pharmacoépidémiologie et informations sur le médicament, pharmacopôle Midi-Pyrénées, faculté de médecine, CHU de Toulouse, 37, allées Jules-Guesde, 31000 Toulouse, France.
authors.forename: Mathilde
authors.initials: M
authors.lastname: Mège
authors.affiliation: Service de pharmacologie médicale et clinique, centre Midi-Pyrénées de pharmacovigilance, pharmacoépidémiologie et informations sur le médicament, pharmacopôle Midi-Pyrénées, faculté de médecine, CHU de Toulouse, 37, allées Jules-Guesde, 31000 Toulouse, France.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Rousseau
authors.affiliation: Service de pharmacologie médicale et clinique, centre Midi-Pyrénées de pharmacovigilance, pharmacoépidémiologie et informations sur le médicament, pharmacopôle Midi-Pyrénées, faculté de médecine, CHU de Toulouse, 37, allées Jules-Guesde, 31000 Toulouse, France.
authors.forename: Haleh
authors.initials: H
authors.lastname: Bagheri
authors.affiliation: Service de pharmacologie médicale et clinique, centre Midi-Pyrénées de pharmacovigilance, pharmacoépidémiologie et informations sur le médicament, pharmacopôle Midi-Pyrénées, faculté de médecine, CHU de Toulouse, 37, allées Jules-Guesde, 31000 Toulouse, France.
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Bondon-Guitton
authors.affiliation: Service de pharmacologie médicale et clinique, centre Midi-Pyrénées de pharmacovigilance, pharmacoépidémiologie et informations sur le médicament, pharmacopôle Midi-Pyrénées, faculté de médecine, CHU de Toulouse, 37, allées Jules-Guesde, 31000 Toulouse, France.
authors.forename: Delphine
authors.initials: D
authors.lastname: Abadie
authors.affiliation: Service de pharmacologie médicale et clinique, centre Midi-Pyrénées de pharmacovigilance, pharmacoépidémiologie et informations sur le médicament, pharmacopôle Midi-Pyrénées, faculté de médecine, CHU de Toulouse, 37, allées Jules-Guesde, 31000 Toulouse, France.
authors.forename: François
authors.initials: F
authors.lastname: Montastruc
authors.affiliation: Département universitaire de médecine générale, faculté de médecine, 31000 Toulouse, France.
authors.forename: Michel
authors.initials: M
authors.lastname: Bismuth
authors.affiliation: Département universitaire de médecine générale, faculté de médecine, 31000 Toulouse, France.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Oustric
authors.affiliation: Service de pharmacologie médicale et clinique, centre Midi-Pyrénées de pharmacovigilance, pharmacoépidémiologie et informations sur le médicament, pharmacopôle Midi-Pyrénées, faculté de médecine, CHU de Toulouse, 37, allées Jules-Guesde, 31000 Toulouse, France.
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Montastruc
mesh_terms: D000293:Adolescent; D000328:Adult; D016907:Adverse Drug Reaction Reporting Systems; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D005602:France; D058005:General Practitioners; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D060735:Pharmacovigilance; D010865:Pilot Projects; D012108:Research Personnel; D055815:Young Adult
keywords: Adverse drug reaction; Effet indésirable médicamenteux; General practitionners; Médecine générale; Pharmacovigilance; Pharmacovigilance network; Pharmacovigilance réseau; Sous-notification; Under-reporting