title: Effect of modifiable lifestyle factors and antioxidant treatment on semen parameters of men with severe oligoasthenoteratozoospermia.
abstract: Severe oligoasthenoteratozoospermia (OAT) refers to impaired count, motility and abnormal sperm morphology of infertile men associated with high chromosomal abnormalities. The objective of the present study was to define a management protocol for severe OAT cases and discover new routes to improve their basic semen parameters. We have applied a therapeutic treatment protocol in a cohort of 210 infertile men diagnosed with extreme severe idiopathic OAT. This therapeutic treatment based on modifying the lifestyle factors combined with antioxidant treatment for 6 months in severe OAT to study its effect on basic semen parameter. Basic semen parameters were assessed before and after applying the therapeutic treatment strategy. Sperm concentration, percentage of total motility and progressive motility were significantly increased after applying the therapeutic treatment (p = .006, p = .001 and p = .001 respectively). On the other hand, abnormal sperm morphology was significantly reduced after therapy (p < .01). In conclusion, the present results suggested that antioxidative supplement in combination with modifying the lifestyle factors in a cumulative treatment period significantly improves the basic semen parameters.
authors.affiliation: Dar Almaraa Fertility and Gynecology Center, Cairo, Egypt.
authors.forename: Y
authors.identifier: http://orcid.org/0000-0003-4804-6879
authors.initials: Y
authors.lastname: Magdi
authors.affiliation: TobLap Company for Laboratories Consultations and Training, Cairo, Egypt.
authors.forename: E
authors.initials: E
authors.lastname: Darwish
authors.affiliation: Department of Urology, Faculty of Medicine, Benha University, Benha, Egypt.
authors.forename: S
authors.initials: S
authors.lastname: Elbashir
authors.affiliation: Department of Urology, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH, USA.
authors.forename: A
authors.initials: A
authors.lastname: Majzoub
authors.affiliation: American Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA.
authors.forename: A
authors.initials: A
authors.lastname: Agarwal
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000627:therapeutic use*; D001205:Ascorbic Acid / Q000008:administration & dosage; D015992:Body Mass Index; D002331:Carnitine / Q000008:administration & dosage; D019587:Dietary Supplements; D004534:Egypt; D006801:Humans; D008019:Life Style; D008297:Male; D009845:Oligospermia / Q000503:physiopathology / Q000628:therapy*; D011446:Prospective Studies; D055101:Semen Analysis; D013076:Sperm Count; D013081:Sperm Motility; D013094:Spermatozoa / Q000002:abnormalities / Q000502:physiology; D014810:Vitamin E / Q000008:administration & dosage
chemical_list: D000975:Antioxidants; D014810:Vitamin E; D001205:Ascorbic Acid; D002331:Carnitine
keywords: antioxidant treatment; lifestyle factors modification; male factor infertility; oligoasthenoteratozoospermia