title: Tumor Blood Vessel Visualization.
abstract: Noninvasive multimodal imaging of tumor blood vessels allows the qualitative and quantitative assessment of morphological, functional, and molecular features of tumor angiogenesis longitudinally in a living organism. In this chapter we focus on the application of magnetic resonance imaging (MRI), computed tomography (CT), ultrasound (US), and positron emission tomography (PET) in tumor blood vessel visualization on the example of breast cancer bone metastasis in a nude rat model. Thereby, materials and methods are described that are needed to obtain complementary data on tumor vascularization from these imaging techniques.
authors.affiliation: Institute of Radiology, University Medical Center Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Palmsanlage 5, 91054, Erlangen, Germany.
authors.forename: Clarissa
authors.initials: C
authors.lastname: Gillmann
authors.affiliation: Institute of Radiology, University Medical Center Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Palmsanlage 5, 91054, Erlangen, Germany. Tobias.Baeurle@uk-erlangen.de.
authors.forename: Tobias
authors.initials: T
authors.lastname: Bäuerle
mesh_terms: D000818:Animals; D001859:Bone Neoplasms / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000556:secondary*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008325:Mammary Neoplasms, Experimental / Q000098:blood supply / Q000000981:diagnostic imaging*; D008819:Mice, Nude; D009389:Neovascularization, Pathologic / Q000000981:diagnostic imaging*; D049268:Positron-Emission Tomography; D051381:Rats; D014057:Tomography, X-Ray Computed; D016217:Ultrasonography, Mammary
keywords: Angiogenesis; Angiography; Computed tomography; Dynamic-contrast-enhanced imaging; Magnetic resonance imaging; Positron emission tomography; Tumor vessels; Ultrasound