title: Retinal oximetry during treatment of retinal vein occlusion by ranibizumab in patients with high blood pressure and dyslipidemia.
abstract: BACKGROUND
  In the present study, we examined retinal vascular oxygen saturation in patients with retinal vein occlusion (RVO), high blood pressure (HBP) and dyslipidemia, before and during intravitreal vascular endothelial growth factor (VEGF) injection (ranibizumab).
  
  
  METHODS
  We retrospectively reviewed the medical records of six patients with visual acuity (VA) reduced by macular edema (ME) secondary to RVO with HBP and dyslipidemia, who underwent intravitreal anti-VEGF injection between October 2014 and February 2015 in the department of ophthalmology of François-Quesnay Hospital at Mantes-la-Jolie (France). The main inclusion criterion was the presence of RVO with ME and decreased VA. The primary endpoint was improvement of retinal venous oxygen saturation in patients with RVO before and 3 months after intravitreal ranibizumab injection. Secondary outcomes were improvement of retinal arterial oxygen saturation, improvement of best-corrected visual acuity (BCVA) on the Early Treatment Diabetic Retinopathy Study (ETDRS) scale, regression of ME measured by the central macular thickness (CMT) in nm and studying the correlation between blood pressure (BP) and retinal venous oxygen saturation before and after ranibizumab.
  
  
  RESULTS
  Six eyes of six patients were included. Before treatment, the mean (standard deviation [SD]) of the retinal venous saturation (%) was 38.1±14.2. Three months after the injections, the mean (SD) of the retinal venous saturation (%) increased statistically significantly 49.2±11 (P=0.03).
  
  
  CONCLUSIONS
  In this study, retinal venous oxygen saturation in patients with RVO, HBP and dyslipidemia was partially normalized during intravitreal ranibizumab treatment.
authors.affiliation: Department of vascular neurology, faculty of medicine, hôpital universitaire de la Pitié-Salpêtrière, Pierre-et-Marie-Curie (Paris VI), 47-83, boulevard de l'Hôpital, 75013 Paris, France. Electronic address: chafik.keilani@aphp.fr.
authors.forename: C
authors.initials: C
authors.lastname: Keilani
authors.affiliation: Department of ophthalmology, hôpital François-Quesnay, 2, boulevard Sully, 78201 Mantes-la-Jolie cedex, France.
authors.forename: A
authors.initials: A
authors.lastname: Halalchi
authors.affiliation: Department of ophthalmology, hôpital François-Quesnay, 2, boulevard Sully, 78201 Mantes-la-Jolie cedex, France.
authors.forename: D
authors.initials: D
authors.lastname: Wakpi Djeugue
authors.affiliation: Department of ophthalmology, hôpital François-Quesnay, 2, boulevard Sully, 78201 Mantes-la-Jolie cedex, France.
authors.forename: A
authors.initials: A
authors.lastname: Regis
authors.affiliation: Department of ophthalmology, hôpital François-Quesnay, 2, boulevard Sully, 78201 Mantes-la-Jolie cedex, France.
authors.forename: S
authors.initials: S
authors.lastname: Abada
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D020533:Angiogenesis Inhibitors / Q000008:administration & dosage*; D050171:Dyslipidemias / Q000150:complications* / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000378:metabolism; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000378:metabolism; D058449:Intravitreal Injections; D008297:Male; D010092:Oximetry; D010100:Oxygen / Q000032:analysis* / Q000378:metabolism; D000069579:Ranibizumab / Q000008:administration & dosage*; D012160:Retina / Q000737:chemistry* / Q000187:drug effects / Q000378:metabolism; D012170:Retinal Vein Occlusion / Q000150:complications* / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000378:metabolism; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence; D016896:Treatment Outcome; D014792:Visual Acuity
chemical_list: D020533:Angiogenesis Inhibitors; D010100:Oxygen; D000069579:Ranibizumab
keywords: Macular edema; Occlusion veineuse rétinienne; Optical coherence tomography; Oxymétrie de la rétine; Ranibizumab; Retinal oximetry; Retinal vein occlusion; Retinal venous oxygen saturation; Saturation veineuse rétinienne en oxygène; Tomographie par cohérence optique; Œdème maculaire