title: Emergence of Colistin Resistance Gene mcr-1 in Cronobacter sakazakii Producing NDM-9 and in Escherichia coli from the Same Animal.
abstract: We report the presence of mcr-1 in Escherichia coli and carbapenem-resistant Cronobacter sakazakii from the same diseased chicken. The mcr-1 gene linked with ISApl1 was located on two different IncI2 plasmids, including one multidrug plasmid in E. coli, whereas fosA3-blaNDM-9was on an IncB/O plasmid in C. sakazakii The development of the fosA3-blaNDM-9resistance region was mediated by IS26 The colocation of mcr-1 or blaNDM-9with other resistance genes will accelerate the dissemination of the two genes.
authors.affiliation: College of Animal Science and Veterinary Medicine, Qingdao Agricultural University, Qingdao, China liubaotao-1986@163.com hush@qau.edu.cn.
authors.forename: Bao-Tao
authors.initials: BT
authors.lastname: Liu
authors.affiliation: Qingdao Academy of Agricultural Sciences, Qingdao, China.
authors.forename: Feng-Jing
authors.initials: FJ
authors.lastname: Song
authors.affiliation: College of Animal Science and Veterinary Medicine, Qingdao Agricultural University, Qingdao, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Zou
authors.affiliation: College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao, China.
authors.forename: Zhi-Hui
authors.initials: ZH
authors.lastname: Hao
authors.affiliation: College of Animal Science and Veterinary Medicine, Qingdao Agricultural University, Qingdao, China liubaotao-1986@163.com hush@qau.edu.cn.
authors.forename: Hu
authors.initials: H
authors.lastname: Shan
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002645:Chickens / Q000382:microbiology; D002681:China; D003091:Colistin / Q000494:pharmacology*; D044083:Cronobacter sakazakii / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D024881:Drug Resistance, Bacterial / Q000187:drug effects / Q000235:genetics*; D004756:Enterobacteriaceae Infections / Q000382:microbiology / Q000662:veterinary; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics*; D004927:Escherichia coli Infections / Q000382:microbiology / Q000662:veterinary; D029968:Escherichia coli Proteins / Q000235:genetics*; D008826:Microbial Sensitivity Tests; D010957:Plasmids / Q000187:drug effects / Q000235:genetics; D001618:beta-Lactamases / Q000235:genetics
chemical_list: D000900:Anti-Bacterial Agents; D029968:Escherichia coli Proteins; C000614037:MCR-1 protein, E coli; D001618:beta-Lactamases; D003091:Colistin
keywords: Cronobacter sakazakii; NDM-9; chicken; insertion sequences; mcr-1