title: Neurogenesis: Regulation by Alternative Splicing and Related Posttranscriptional Processes.
abstract: The complexity of the mammalian brain requires highly specialized protein function and diversity. As neurons differentiate and the neuronal circuitry is established, several mRNAs undergo alternative splicing and other posttranscriptional changes that expand the variety of protein isoforms produced. Recent advances are beginning to shed light on the molecular mechanisms that regulate isoform switching during neurogenesis and the role played by specific RNA binding proteins in this process. Neurogenesis and neuronal wiring were recently shown to also be regulated by RNA degradation through nonsense-mediated decay. An additional layer of regulatory complexity in these biological processes is the interplay between alternative splicing and long noncoding RNAs. Dysregulation of posttranscriptional regulation results in defective neuronal differentiation and/or synaptic connections that lead to neurodevelopmental and psychiatric disorders.
authors.affiliation: 1 Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain.|2 National Heart and Lung Institute, Imperial College London, London, UK.
authors.forename: Enrique
authors.initials: E
authors.lastname: Lara-Pezzi
authors.affiliation: 3 Departamento de Bioingeniería e Ingeniería Aeroespacial, Universidad Carlos III, Madrid, Spain.|4 Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.
authors.forename: Manuel
authors.initials: M
authors.lastname: Desco
authors.affiliation: 1 Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain.
authors.forename: Alberto
authors.initials: A
authors.lastname: Gatto
authors.affiliation: 3 Departamento de Bioingeniería e Ingeniería Aeroespacial, Universidad Carlos III, Madrid, Spain.|4 Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.
authors.forename: María Victoria
authors.initials: MV
authors.lastname: Gómez-Gaviro
mesh_terms: D017398:Alternative Splicing / Q000502:physiology*; D000818:Animals; D001921:Brain / Q000166:cytology / Q000502:physiology*; D015870:Gene Expression / Q000502:physiology; D006801:Humans; D055495:Neurogenesis / Q000502:physiology*; D009474:Neurons / Q000502:physiology; D012323:RNA Processing, Post-Transcriptional / Q000502:physiology*
keywords: alternative splicing; molecular neurology; molecular psychiatry; neurogenesis; noncoding RNAs; nonsense-mediated decay