title: Diagnostic and prognostic value of serum vitronectin levels in human glioma.
abstract: OBJECTIVE
  Vitronectin is an extracellular matrix protein, the synthesis of which by glioma cells correlates with tumor grade. The current study was designed to investigate the relationship between serum vitronectin levels and clinicopathological characteristics, diagnosis and prognosis in glioma patients.
  
  
  METHODS
  In a prospective observatory study, a total of 98 glioma patients, 98 healthy controls, 98 other non-glioma brain tumors, and 98 other non-tumor neurological diseases were recruited. Following univariate analyses, multivariate analyses were performed to explore the associations of serum vitronectin levels with survival and clinicopathological parameters. Receiver operating characteristic curve analysis was done to assess its diagnostic and prognostic predictive value.
  
  
  RESULTS
  Serum vitronectin levels were significantly elevated in glioma patients as compared with other groups. High Wealth Health Organization grade was independently associated with high vitronectin levels. Serum vitronectin levels could significantly distinguish glioma patients from other groups and discriminate high-grade glioma from low-grade glioma. Vitronectin levels markedly predicted 5-year progression and 5-year mortality. Moreover, serum vitronectin was identified as an independent predictor for 5-year overall survival and 5-year progression-free survival as well as 5-year mortality and 5-year progression.
  
  
  CONCLUSIONS
  Serum vitronectin may be a promising diagnostic and prognostic biomarker that can be detected in the peripheral blood of patients with glioma.
authors.affiliation: Department of Neurosurgery, The Central Hospital of Wenzhou City, Wenzhou Medical University Dingli Clinical College, 32 Dajian Lane, Wenzhou 325000, Zhejiang Province, China.
authors.forename: Mao-Hua
authors.initials: MH
authors.lastname: Chen
authors.affiliation: Department of Neurosurgery, The Central Hospital of Wenzhou City, Wenzhou Medical University Dingli Clinical College, 32 Dajian Lane, Wenzhou 325000, Zhejiang Province, China.
authors.forename: Chuan
authors.initials: C
authors.lastname: Lu
authors.affiliation: Department of Neurosurgery, The Central Hospital of Wenzhou City, Wenzhou Medical University Dingli Clinical College, 32 Dajian Lane, Wenzhou 325000, Zhejiang Province, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Sun
authors.affiliation: Department of Neurosurgery, The Central Hospital of Wenzhou City, Wenzhou Medical University Dingli Clinical College, 32 Dajian Lane, Wenzhou 325000, Zhejiang Province, China.
authors.forename: Xian-Dong
authors.initials: XD
authors.lastname: Chen
authors.affiliation: Department of Neurosurgery, The Central Hospital of Wenzhou City, Wenzhou Medical University Dingli Clinical College, 32 Dajian Lane, Wenzhou 325000, Zhejiang Province, China.
authors.forename: Jun-Xia
authors.initials: JX
authors.lastname: Dai
authors.affiliation: Department of Neurosurgery, The Central Hospital of Wenzhou City, Wenzhou Medical University Dingli Clinical College, 32 Dajian Lane, Wenzhou 325000, Zhejiang Province, China.
authors.forename: Jian-Yong
authors.initials: JY
authors.lastname: Cai
authors.affiliation: Department of Cerebrovessel, The People's Hospital of Qingyuan, The Sixth Affiliated Hospital of Guangzhou Medical University, B24 Xinchengyinquan Road, Qingcheng District, Qingyuan 511518, Guangdong Province, China. Electronic address: Jianchina2008@yeah.net.
authors.forename: Xiang-Lin
authors.initials: XL
authors.lastname: Chen
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood; D001932:Brain Neoplasms / Q000097:blood* / Q000401:mortality / Q000473:pathology / Q000628:therapy; D018450:Disease Progression; D005260:Female; D005910:Glioma / Q000097:blood* / Q000401:mortality / Q000473:pathology / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D011379:Prognosis; D011446:Prospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome; D047368:Tumor Burden; D019096:Vitronectin / Q000097:blood*
chemical_list: D014408:Biomarkers, Tumor; D019096:Vitronectin
keywords: Diagnosis; Glioma; Prognosis; Serum vitronectin