title: Radical scavenging and antibacterial activity of caffemides against gram positive, gram negative and clinical drug resistance bacteria.
abstract: A new series of caffemide were synthesized and their antioxidant and antibacterial activities were explored. Antioxidant and antibacterial activities were measured of different structures of caffemide containing different functional groups. Anti-oxidative caffemides 1b and 1g showed significantly higher activity against different bacteria with MIC values less than 50μg/ml. These anti-oxidative and antibacterial properties of caffemides might be helpful for the treatment of secondary infections and discovery of new antibiotics.
authors.affiliation: Department of Chemistry, IIT-Kharagpur 721302, West Bengal, India.
authors.forename: Kaushik
authors.initials: K
authors.lastname: Misra
authors.affiliation: Department of Chemistry, IIT-Kharagpur 721302, West Bengal, India.
authors.forename: Himadri Sekhar
authors.initials: HS
authors.lastname: Maity
authors.affiliation: Department of Chemistry, IIT-Kharagpur 721302, West Bengal, India. Electronic address: ahinnag@chem.iitkgp.ernet.in.
authors.forename: Ahindra
authors.initials: A
authors.lastname: Nag
authors.affiliation: School of Biotechnology, KIIT University, Bhubaneswar 751024, Odisha, India.
authors.forename: Avinash
authors.initials: A
authors.lastname: Sonawane
mesh_terms: D000627:Aminophenols / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002109:Caffeic Acids / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D024881:Drug Resistance, Bacterial / Q000187:drug effects*; D016166:Free Radical Scavengers / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: D000627:Aminophenols; D000900:Anti-Bacterial Agents; D002109:Caffeic Acids; D016166:Free Radical Scavengers
keywords: Caffemide; DPPH; M. smegmatis; P. aeruginosa; S. aureus