title: Increased levels of soluble corin in pre-eclampsia and fetal growth restriction.
abstract: Atrial natriuretic peptide is biologically activated by the atrial natriuretic peptide-converting enzyme, corin, and has an important role in regulating blood pressure. We detected elevated serum corin levels in women with pre-eclampsia. Interestingly, the serum corin levels were also found to be elevated in pregnancies with a related disorder, unexplained fetal growth restriction (FGR) without hypertension, suggesting that this phenomenon is not simply a response to maternal hypertension. CORIN mRNA levels were not elevated in placentas from pre-eclampsia or unexplained FGR cases. Likewise, similar signal intensities were found for corin in placental syncytiotrophoblast cells by immunostaining. In contrast, corin signals were higher in maternal decidua cells from pre-eclampsia and unexplained FGR cases. These data suggest that corin may be upregulated in maternal decidua in response to an etiologic pathway that is common to pre-eclampsia and FGR.
authors.affiliation: Department of Obstetrics and Gynecology, Fujita Health University School of Medicine, Toyoake, Japan; Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Miyazaki
authors.affiliation: Department of Obstetrics and Gynecology, Fujita Health University School of Medicine, Toyoake, Japan. Electronic address: nharuki@fujita-hu.ac.jp.
authors.forename: Haruki
authors.initials: H
authors.lastname: Nishizawa
authors.affiliation: Department of Obstetrics and Gynecology, Fujita Health University School of Medicine, Toyoake, Japan.
authors.forename: Asuka
authors.initials: A
authors.lastname: Kambayashi
authors.affiliation: Department of Obstetrics and Gynecology, Fujita Health University School of Medicine, Toyoake, Japan; Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Japan.
authors.forename: Mayuko
authors.initials: M
authors.lastname: Ito
authors.affiliation: Department of Obstetrics and Gynecology, Fujita Health University School of Medicine, Toyoake, Japan; Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Japan.
authors.forename: Yoshiteru
authors.initials: Y
authors.lastname: Noda
authors.affiliation: Department of Obstetrics and Gynecology, Fujita Health University School of Medicine, Toyoake, Japan; Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Japan.
authors.forename: Sumire
authors.initials: S
authors.lastname: Terasawa
authors.affiliation: Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Japan.
authors.forename: Takema
authors.initials: T
authors.lastname: Kato
authors.affiliation: Department of Obstetrics and Gynecology, Fujita Health University School of Medicine, Toyoake, Japan.
authors.forename: Hironori
authors.initials: H
authors.lastname: Miyamura
authors.affiliation: Department of Pathology, Fujita Health University School of Medicine, Toyoake, Japan.
authors.forename: Kazuya
authors.initials: K
authors.lastname: Shiogama
authors.affiliation: Department of Obstetrics and Gynecology, Fujita Health University School of Medicine, Toyoake, Japan.
authors.forename: Takao
authors.initials: T
authors.lastname: Sekiya
authors.affiliation: Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Kurahashi
authors.affiliation: Department of Obstetrics and Gynecology, Fujita Health University School of Medicine, Toyoake, Japan.
authors.forename: Takuma
authors.initials: T
authors.lastname: Fujii
mesh_terms: D000328:Adult; D003656:Decidua / Q000378:metabolism; D005260:Female; D005317:Fetal Growth Retardation / Q000097:blood* / Q000378:metabolism; D006801:Humans; D010920:Placenta / Q000378:metabolism; D011225:Pre-Eclampsia / Q000097:blood* / Q000378:metabolism; D011247:Pregnancy; D012697:Serine Endopeptidases / Q000097:blood* / Q000378:metabolism; D014327:Trophoblasts / Q000378:metabolism
chemical_list: C119812:CORIN protein, human; D012697:Serine Endopeptidases
keywords: Corin; Fetal growth restriction; Pre-eclampsia