title: Targeted Magnetic Liposomes Loaded with Doxorubicin.
abstract: Targeted delivery systems for anticancer drugs are urgently needed to achieve maximum therapeutic efficacy by site-specific accumulation and thereby minimizing adverse effects resulting from systemic distribution of many potent anticancer drugs. We have prepared folate receptor-targeted magnetic liposomes loaded with doxorubicin, which are designed for tumor targeting through a combination of magnetic and biological targeting. Furthermore, these liposomes are designed for hyperthermia-induced drug release to be mediated by an alternating magnetic field and to be traceable by magnetic resonance imaging (MRI). Here, detailed preparation and relevant characterization techniques of targeted magnetic liposomes encapsulating doxorubicin are described.
authors.affiliation: Department of Biosciences and Bioengineering, IIT Bombay, Mumbai, India. pallab.pradhan@bme.gatech.edu.|Institute of Molecular Immunology & Experimental Oncology, Technische Universität München, Munich, Germany. pallab.pradhan@bme.gatech.edu.|Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 315 Ferst Drive, Atlanta, GA, 30332-0535, USA. pallab.pradhan@bme.gatech.edu.
authors.forename: Pallab
authors.initials: P
authors.lastname: Pradhan
authors.affiliation: Department of Biosciences and Bioengineering, IIT Bombay, Mumbai, India.
authors.forename: Rinti
authors.initials: R
authors.lastname: Banerjee
authors.affiliation: Department of Metallurgical Engineering and Materials Science, IIT Bombay, Mumbai, India.
authors.forename: Dhirendra
authors.initials: D
authors.lastname: Bahadur
authors.affiliation: Institute of Molecular Immunology & Experimental Oncology, Technische Universität München, Munich, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Koch
authors.affiliation: Institute of Molecular Immunology & Experimental Oncology, Technische Universität München, Munich, Germany.
authors.forename: Olga
authors.initials: O
authors.lastname: Mykhaylyk
authors.affiliation: Institute of Molecular Immunology & Experimental Oncology, Technische Universität München, Munich, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Plank
mesh_terms: D016923:Cell Death; D004317:Doxorubicin / Q000494:pharmacology*; D005434:Flow Cytometry; D058973:Folate Receptors, GPI-Anchored / Q000378:metabolism; D005492:Folic Acid / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D008081:Liposomes / Q000737:chemistry*; D008280:Magnetics; D008856:Microscopy, Fluorescence; D053758:Nanoparticles / Q000737:chemistry; D010714:Phosphatidylethanolamines / Q000737:chemistry; D010743:Phospholipids / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry
chemical_list: D058973:Folate Receptors, GPI-Anchored; D008081:Liposomes; D010714:Phosphatidylethanolamines; D010743:Phospholipids; C038089:1,2-distearoylphosphatidylethanolamine; D011092:Polyethylene Glycols; D004317:Doxorubicin; D005492:Folic Acid
keywords: Doxorubicin; Folate; Magnetic liposomes; Magnetic nanoparticles; Targeted