title: Intrathecal/Intraventricular Linezolid in Multidrug-ResistantEnterococcus faecalisVentriculitis.
abstract: BackgroundThe use of intrathecal antibiotic therapy for the treatment of ventriculitis and/or meningitis has demonstrated efficacy especially when sterilization of the cerebrospinal fluid is not possible with intravenous antibiotics alone.Case DescriptionWe describe the successful treatment ofEnterococcus faecalisventriculitis utilizing intrathecal linezolid in a 32-year-old female patient with severe allergy to vancomycin, prohibitive bacterial susceptibilities, and failure of previous attempts to sterilize the cerebrospinal fluid despite multimodal treatment.ConclusionIntrathecal linezolid is a useful treatment in the setting of multidrug-resistant bacterial ventriculitis. We present a useful dosing regimen for the administration of intrathecal linezolid.
authors.affiliation: Department of Internal Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States.
authors.forename: Brian F
authors.initials: BF
authors.lastname: Lich
authors.affiliation: Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States.
authors.forename: Andrew K
authors.initials: AK
authors.lastname: Conner
authors.affiliation: Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States.
authors.forename: Joshua D
authors.initials: JD
authors.lastname: Burks
authors.affiliation: Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States.
authors.forename: Chad A
authors.initials: CA
authors.lastname: Glenn
authors.affiliation: Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States.
authors.forename: Michael E
authors.initials: ME
authors.lastname: Sughrue
keywords: external ventricular drain; intrathecal; linezolid; ventriculitis