title: Intramolecular radical non-reductive alkylation of ketones via transient enamines.
abstract: Radical cyclization of dichloroacetamide-tethered ketones using pyrrolidine, AIBN and TTMSS under microwave activation gave 2-azabicyclo[3.3.1]nonan-3,6-diones. In a five-minute one-pot process, after the generation of an enamine, intramolecular addition of a carbamoylchloromethyl radical, and oxidation of the α-aminoalkyl radical intermediate, the resulting iminium salt evolved to the corresponding enamine and, after a workup, to the alkylated ketone.
authors.affiliation: Laboratori de Química Orgànica, Facultat de Farmàcia, IBUB, Universitat de Barcelona, Av. Joan XXIII s/n, 08028-Barcelona, Spain. faiza.diaba@ub.edu josep.bonjoch@ub.edu.
authors.forename: Faïza
authors.initials: F
authors.lastname: Diaba
authors.affiliation: Laboratori de Química Orgànica, Facultat de Farmàcia, IBUB, Universitat de Barcelona, Av. Joan XXIII s/n, 08028-Barcelona, Spain. faiza.diaba@ub.edu josep.bonjoch@ub.edu.
authors.forename: Juan A
authors.initials: JA
authors.lastname: Montiel
authors.affiliation: Laboratori de Química Orgànica, Facultat de Farmàcia, IBUB, Universitat de Barcelona, Av. Joan XXIII s/n, 08028-Barcelona, Spain. faiza.diaba@ub.edu josep.bonjoch@ub.edu.
authors.forename: Josep
authors.identifier: http://orcid.org/0000-0002-5551-6720
authors.initials: J
authors.lastname: Bonjoch