title: Adiponectin and end-stage renal disease.
abstract: Adiponectin (ADPN) is an adipokine with significant anti-inflammatory, insulin-sensitizing and anti-atherogenic properties, which is generally associated with a beneficial cardiometabolic profile. Paradoxically, end-stage renal disease (ESRD) is characterized by markedly increased plasma ADPN levels and increased cardiovascular risk. In spite of the cardioprotective properties attributed to adiponectin, cardiovascular complications remain the main cause of mortality in the ESRD population. Furthermore, these patients have enhanced chronic inflammation, increased insulin resistance and persistent protein-energy wasting. Studies of the impact of ADPN on clinical outcomes among ESRD patients have so far yielded contradictory results. This review article summarizes the current knowledge on ADPN functions and explores the role of ADPN in ESRD patients, with specific focus on inflammation, insulin resistance, cardiovascular disease and wasting.
authors.affiliation: Department of Nutrition and Dietetics, Technological Educational Institute of Crete, Crete, Greece. anmarkaki@staff.teicrete.gr.
authors.forename: Anastasia
authors.initials: A
authors.lastname: Markaki
authors.affiliation: Department of Nutrition and Dietetics, Technological Educational Institute of Crete, Crete, Greece.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Psylinakis
authors.affiliation: Department of Nutrition and Dietetics, Technological Educational Institute of Crete, Crete, Greece.
authors.forename: Aspasia
authors.initials: A
authors.lastname: Spyridaki
mesh_terms: D052242:Adiponectin / Q000378:metabolism*; D000818:Animals; D002318:Cardiovascular Diseases / Q000209:etiology / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000378:metabolism; D007333:Insulin Resistance; D007676:Kidney Failure, Chronic / Q000150:complications / Q000378:metabolism* / Q000401:mortality; D011379:Prognosis; D011502:Protein-Energy Malnutrition / Q000209:etiology / Q000378:metabolism; D054419:Receptors, Adiponectin / Q000378:metabolism; D012307:Risk Factors; D015398:Signal Transduction
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D054419:Receptors, Adiponectin