title: Quantification in time-domain diffuse optical tomography using Mellin-Laplace transforms.
abstract: Simulations and phantom measurements are used to evaluate the ability of time-domain diffuse optical tomography using Mellin-Laplace transforms to quantify the absorption perturbation of centimetric objects immersed at depth 1-2 cm in turbid media. We find that the estimated absorption coefficient varies almost linearly with the absorption change in the range of 0-0.15 cm-1but is underestimated by a factor that depends on the inclusion depth (~2, 3 and 6 for depths of 1.0, 1.5 and 2.0 cm respectively). For larger absorption changes, the variation is sublinear with ~20% decrease for δμa= 0.37 cm-1. By contrast, constraining the absorption change to the actual volume of the inclusion may considerably improve the accuracy and linearity of the reconstructed absorption.
authors.affiliation: Univ. Grenoble Alpes, F-38000 Grenoble, France CEA, LETI, MINATEC Campus, F-38054 Grenoble, France.
authors.forename: Judy
authors.initials: J
authors.lastname: Zouaoui
authors.affiliation: Politecnico di Milano, Dipartimento di Fisica, Piazza Leonardo da Vinci 32, Milano I-20133, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Di Sieno
authors.affiliation: Univ. Grenoble Alpes, F-38000 Grenoble, France CEA, LETI, MINATEC Campus, F-38054 Grenoble, France.
authors.forename: Lionel
authors.initials: L
authors.lastname: Hervé
authors.affiliation: Politecnico di Milano, Dipartimento di Fisica, Piazza Leonardo da Vinci 32, Milano I-20133, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Pifferi
authors.affiliation: Politecnico di Milano, Dipartimento di Fisica, Piazza Leonardo da Vinci 32, Milano I-20133, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Farina
authors.affiliation: Politecnico di Milano, Dipartimento di Fisica, Piazza Leonardo da Vinci 32, Milano I-20133, Italy.
authors.forename: Alberto Dalla
authors.initials: AD
authors.lastname: Mora
authors.affiliation: Univ. Grenoble Alpes, LIPhy, F-38000 Grenoble, France.
authors.forename: Jacques
authors.initials: J
authors.lastname: Derouard
authors.affiliation: Univ. Grenoble Alpes, F-38000 Grenoble, France CEA, LETI, MINATEC Campus, F-38054 Grenoble, France.
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Dinten
keywords: (030.5260) Photon counting; (100.3010) Image reconstruction techniques; (110.0113) Imaging through turbid media; (110.6960) Tomography; (170.6920) Time-resolved imaging; (230.5160) Photodetectors