title: Cerebral Venous Sinus Thrombosis in A Patient with Sjögren's Syndrome with Atypical Antibodies: A Case Report.
abstract: BACKGROUND
  Although Sjögren's syndrome has been known to complicate with white matter lesions, encephalopathy, or stroke, reports of cerebral venous sinus thrombosis due to Sjögren's syndrome with atypical antibodies are rare.
  
  
  METHODS
  A 50-year-old woman was admitted to our neurological ward with nausea and vomiting following acute onset of severe headache in the left occipital region. Brain computed tomography revealed no abnormalities. The patient was fully conscious, with normal cognitive functioning, but exhibited unsteady tandem gait. Both magnetic resonance venography and computed tomography venography suggested left transverse sinus blockage. Intravenous enoxaparin, followed by oral warfarin, was initiated as treatment for cerebral venous sinus thrombosis. After investigation, Sjögren's syndrome was diagnosed and lupus anticoagulant antibody test was positive. The patient was treated with hydroxychloroquine, and appeared fully recovered at the 6-month follow-up, with no clinical or radiological signs of relapse.
  
  
  CONCLUSIONS
  This case reports the relationship between cerebral venous sinus thrombosis and Sjögren's syndrome. It is necessary to screen autoimmune disorders in patients with cerebral venous sinus thrombosis that present with no common risk factors of venous thrombosis in order to prevent inappropriate management, and potentially adverse outcomes.
authors.affiliation: Department of Neurology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
authors.forename: Tsung-Han
authors.initials: TH
authors.lastname: Ho
authors.affiliation: Department of Neurology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
authors.forename: Yu-Wei
authors.initials: YW
authors.lastname: Hsu
authors.affiliation: Department of Radiology, Tri-Service General Hospital, National Defense Medical Center.
authors.forename: Chih-Wei
authors.initials: CW
authors.lastname: Wang
authors.affiliation: Department of Neurology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
authors.forename: Jiunn-Tay
authors.initials: JT
authors.lastname: Lee
authors.affiliation: Department of Neurology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
authors.forename: Chi-Hsin
authors.initials: CH
authors.lastname: Ting
authors.affiliation: Department of Neurology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
authors.forename: Fu-Chi
authors.initials: FC
authors.lastname: Yang
mesh_terms: D005260:Female; D006801:Humans; D016682:Lupus Coagulation Inhibitor / Q000276:immunology*; D008875:Middle Aged; D012851:Sinus Thrombosis, Intracranial / Q000175:diagnosis / Q000209:etiology / Q000276:immunology; D012859:Sjogren's Syndrome / Q000150:complications / Q000175:diagnosis / Q000276:immunology
chemical_list: D016682:Lupus Coagulation Inhibitor