title: Evaluation of Veterinary-Specific Interpretive Criteria for Susceptibility Testing of Streptococcus equi Subspecies with Trimethoprim-Sulfamethoxazole and Trimethoprim-Sulfadiazine.
abstract: Antimicrobial susceptibility test results for trimethoprim-sulfadiazine with Streptococcus equi subspecies are interpreted based on human data for trimethoprim-sulfamethoxazole. The veterinary-specific data generated in this study support a single breakpoint for testing trimethoprim-sulfamethoxazole and/or trimethoprim-sulfadiazine with S. equi This study indicates trimethoprim-sulfamethoxazole as an acceptable surrogate for trimethoprim-sulfadiazine with S. equi.
authors.affiliation: Zoetis Global Therapeutics Research, Kalamazoo, Michigan, USA carmen.sdk@hotmail.com jeffrey.l.watts@zoetis.com.|Zoetis Inc., Paris, France.|Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, Denmark.
authors.forename: Carmen
authors.initials: C
authors.lastname: Sadaka
authors.affiliation: Zoetis Inc., Paris, France.
authors.forename: Theo
authors.initials: T
authors.lastname: Kanellos
authors.affiliation: Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, Denmark.|Department of Biomedical Sciences, Ross University School of Veterinary Medicine, Basseterre, St. Kitts and Nevis, West Indies.
authors.forename: Luca
authors.initials: L
authors.lastname: Guardabassi
authors.affiliation: Zoetis Global Therapeutics Research, Kalamazoo, Michigan, USA.
authors.forename: Joseph
authors.initials: J
authors.lastname: Boucher
authors.affiliation: Zoetis Global Therapeutics Research, Kalamazoo, Michigan, USA carmen.sdk@hotmail.com jeffrey.l.watts@zoetis.com.
authors.forename: Jeffrey L
authors.initials: JL
authors.lastname: Watts
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004338:Drug Combinations; D008826:Microbial Sensitivity Tests / Q000379:methods / Q000592:standards*; D018502:Streptococcus equi / Q000187:drug effects*; D013411:Sulfadiazine / Q000494:pharmacology*; D014295:Trimethoprim / Q000494:pharmacology*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000494:pharmacology*; D014730:Veterinary Medicine / Q000379:methods / Q000592:standards*; D000096926:Benzenesulfonamides
chemical_list: D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D013411:Sulfadiazine; D014295:Trimethoprim; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; C024873:sulfadiazine, trimethoprim drug combination; D000096926:Benzenesulfonamides
keywords: breakpoints; horses; interpretive criteria; potentiated sulfonamides; strangles; veterinary microbiology