title: Interferon-induced transmembrane protein 1 (IFITM1) is required for the progression of colorectal cancer.
abstract: Interferon-induced transmembrane protein 1 (IFITM1) has been shown to be implicated in multiple cancers, yet little is known about biological significance of IFITM1 in colorectal cancer. Here, we show that IFITM1 is highly expressed in metastatic colorectal cancer cell lines as well as colorectal patient-derived tumor samples, and its expression is associated with a poor prognosis of the disease. Also, IFITM1 depletion resulted in a significant reduction in the mobility of cancer cell lines, whereas ectopic expression of IFITM1 promoted the migration of cancer cells. Epithelial-mesenchymal transition (EMT) signature was dysregulated by both loss and gain of function of IFITM1, which was partially reverted by Caveolin-1 (CAV1). Therefore, these results suggest that IFITM1 may be a prognostic marker and an attractive target to achieve better therapeutic outcomes in colorectal cancer.
authors.affiliation: Soonchunhyang Institute of Medi-bio Science (SIMS), Soonchunhyang University, Republic of Korea.
authors.forename: Ita Novita
authors.initials: IN
authors.lastname: Sari
authors.affiliation: Soonchunhyang Institute of Medi-bio Science (SIMS), Soonchunhyang University, Republic of Korea.
authors.forename: Ying-Gui
authors.initials: YG
authors.lastname: Yang
authors.affiliation: Soonchunhyang Institute of Medi-bio Science (SIMS), Soonchunhyang University, Republic of Korea.
authors.forename: Lan Thi Hanh
authors.initials: LT
authors.lastname: Phi
authors.affiliation: Soonchunhyang Medical Science Research Institute, College of Medicine, Soonchunhyang University, Republic of Korea.
authors.forename: Hyungjoo
authors.initials: H
authors.lastname: Kim
authors.affiliation: Department of Surgery, Department of Pathology, College of Medicine, Soonchunhyang University, Republic of Korea.
authors.forename: Moo Jun
authors.initials: MJ
authors.lastname: Baek
authors.affiliation: Soonchunhyang Medical Science Research Institute, College of Medicine, Soonchunhyang University, Republic of Korea.
authors.forename: Dongjun
authors.initials: D
authors.lastname: Jeong
authors.affiliation: Soonchunhyang Institute of Medi-bio Science (SIMS), Soonchunhyang University, Republic of Korea.
authors.forename: Hyog Young
authors.initials: HY
authors.lastname: Kwon
mesh_terms: D000328:Adult; D000368:Aged; D000943:Antigens, Differentiation / Q000502:physiology*; D051242:Caveolin 1 / Q000502:physiology; D045744:Cell Line, Tumor; D002465:Cell Movement; D049109:Cell Proliferation; D015179:Colorectal Neoplasms / Q000209:etiology* / Q000473:pathology; D018450:Disease Progression; D058750:Epithelial-Mesenchymal Transition; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D034741:RNA, Small Interfering / Q000235:genetics
chemical_list: D000943:Antigens, Differentiation; D051242:Caveolin 1; D034741:RNA, Small Interfering; C062010:leu-13 antigen
keywords: IFITM1; colorectal cancer; metastasis; prognosis