title: Analysis ofIL-33gene polymorphism (rs11792633 C/T) and risk of schizophrenia.
abstract: Recently, inflammation has been found to be a significant factor in the development of Schizophrenia (SCZ). The aim of the present research was to investigate whether interleukin-33 (IL-33, OMIM: 608678) gene polymorphism (rs11792633, C/T) is associated with the development of SCZ or not. DNA was isolated from the serum of 70 patients with SCZ and 70 healthy controls. The PCR based method was used for detection of theIL-33polymorphism. The CT (OR=0.05, 95% CI: 0.003-0.057, P<0.001) and TT (OR=0.12, 95% CI: 0.028-0.46, P<0.001) genotypes significantly decreased the risk of SCZ. Our present findings indicate that theIL-33polymorphism associated with the risk of SCZ.
authors.affiliation: Department of Biology, University of Sistan and Baluchestan, Zahedan, Iran.
authors.forename: Dor Mohammad
authors.initials: DM
authors.lastname: Kordi-Tamandani
authors.affiliation: Department of Biology, Ferdowssi University of Mashhad, Mashhad, Iran.
authors.forename: Ahmad Reza
authors.initials: AR
authors.lastname: Bahrami
authors.affiliation: Department of Biology, Ferdowssi University of Mashhad, Mashhad, Iran.
authors.forename: Raziye
authors.initials: R
authors.lastname: Sabbaghi-Ghale-No
authors.affiliation: Department of Biology, University of Sistan and Baluchestan, Zahedan, Iran.
authors.forename: Hanieh
authors.initials: H
authors.lastname: Soleimani
authors.affiliation: Department of Biology, University of Sistan and Baluchestan, Zahedan, Iran.
authors.forename: Tayebe
authors.initials: T
authors.lastname: Baranzehi
keywords: IL-33; Polymorphism; Schizophrenia