title: Naphthoquinones from Onosma paniculatum with Potential Anti-inflammatory Activity.
abstract: Four new naphthoquinones (1-4), including a dimeric one, shikometabolin G (1), together with six known ones (6-10), were isolated from the methanol extract ofOnosma paniculatum. Their structures were established based on the analysis of NMR and MS spectroscopic data. All of the compounds were evaluated for inhibitory effects on NO production in murine macrophage RAW 264.7 cells. Compounds2, 3, 5, 6, 7, 8, and10displayed good activity on the inhibition of NO production (IC50= 0.4-16.5 µM), suggesting the potential property of anti-inflammation.
authors.affiliation: Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming, China.
authors.forename: Miao
authors.initials: M
authors.lastname: Dong
authors.affiliation: Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Liu
authors.affiliation: Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, China.
authors.forename: Yan-Hong
authors.initials: YH
authors.lastname: Li
authors.affiliation: Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, China.
authors.forename: Xuan-Qin
authors.initials: XQ
authors.lastname: Chen
authors.affiliation: Paris School of Business, Management and Strategy Department, Paris, France.
authors.forename: Kai
authors.initials: K
authors.lastname: Luo
authors.affiliation: Université Pierre et Marie Curie-Paris 6, Institute Parisien de Chimie Moléculaire, Paris, France.
authors.forename: Yong-Min
authors.initials: YM
authors.lastname: Zhang
authors.affiliation: Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, China.
authors.forename: Rong-Tao
authors.initials: RT
authors.lastname: Li
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000302:isolation & purification* / Q000494:pharmacology; D028082:Boraginaceae / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D051379:Mice; D009285:Naphthoquinones / Q000302:isolation & purification* / Q000494:pharmacology; D009569:Nitric Oxide / Q000096:biosynthesis; D018517:Plant Roots / Q000737:chemistry; D000067996:RAW 264.7 Cells
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004365:Drugs, Chinese Herbal; D009285:Naphthoquinones; D009569:Nitric Oxide