title: Minimal Change Nephrotic Syndrome Sequentially Complicated by Acute Kidney Injury and Painful Skin Ulcers due to Calciphylaxis.
abstract: Calciphylaxis is rare cutaneous manifestation associated with painful skin ulceration and necrosis. It primarily occurs in patients with end-stage chronic kidney disease. In this report, we would like to show our experience with a male patient presenting with minimal change nephrotic syndrome that was sequentially complicated by acute kidney injury and painful ulcerative cutaneous lesions due to calciphylaxis. There seemed to be several contributing factors, including a disturbance of the patient's mineral metabolism and the systemic use of glucocorticoids and warfarin. Various concerns regarding the diagnostic and therapeutic conundrums that were encountered in the present case are also discussed.
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Japan.
authors.forename: Ryuta
authors.initials: R
authors.lastname: Sato
authors.forename: Tetsu
authors.initials: T
authors.lastname: Akimoto
authors.forename: Toshimi
authors.initials: T
authors.lastname: Imai
authors.forename: Saki
authors.initials: S
authors.lastname: Nakagawa
authors.forename: Mari
authors.initials: M
authors.lastname: Okada
authors.forename: Atsushi
authors.initials: A
authors.lastname: Miki
authors.forename: Shinichi
authors.initials: S
authors.lastname: Takeda
authors.forename: Hisashi
authors.initials: H
authors.lastname: Yamamoto
authors.forename: Osamu
authors.initials: O
authors.lastname: Saito
authors.forename: Shigeaki
authors.initials: S
authors.lastname: Muto
authors.forename: Eiji
authors.initials: E
authors.lastname: Kusano
authors.forename: Daisuke
authors.initials: D
authors.lastname: Nagata
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D000328:Adult; D002115:Calciphylaxis / Q000150:complications* / Q000473:pathology / Q000628:therapy; D006801:Humans; D008297:Male; D009402:Nephrosis, Lipoid / Q000150:complications* / Q000473:pathology / Q000628:therapy; D012883:Skin Ulcer / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D014859:Warfarin / Q000627:therapeutic use
chemical_list: D014859:Warfarin