title: Immune Correlates of Resistance toTrichinella spiralisReinfection in Mice.
abstract: The immune correlate of host resistance induced by reinfection ofTrichinella spiralisremains unclear. In this study, we investigated immune correlates between the resistance and serum IgG antibody level, CD23+IgM+B cells, and eosinophil responses induced byT. spiralisreinfection. Mice were primarily infected with 10 or 100T. spiralislarvae (10 TS, 100 TS), respectively, and after 4 weeks, they were challenge infected with 100T. spiralislarvae (10-100 TS, 100-100 TS). Upon challenge infections, 10-100 TS mice induced significantly higher levels ofT. spiralis-specific total IgG antibody responses in sera and antibody secreting cell responses in spleens compared to 100-100 TS mice, resulting in significantly reduced worm burdens in 10-100 TS mice (60% and 70% reductions for adult and larvae, respectively). Higher levels of eosinophils were found in mice primarily infected with 10 TS compared to those of 100 TS at week 8 upon challenge. CD23+IgM+B cells were found to be increased significantly in mice primarily infected with 10 TS. These results indicate that primary infection of 10 larvae ofT. spiralis, rather than 100 larvae, induces significant resistance against reinfection which closely correlated withT. spiralis-specific IgG, eosinophil, and CD23+IgM+B cell responses.
authors.affiliation: Department of Biomedical Science, Graduate School, Kyung Hee University, Seoul 02447, Korea.|Department of Medical Zoology, Kyung Hee University School of Medicine, Seoul 02447, Korea.
authors.forename: Ki-Back
authors.initials: KB
authors.lastname: Chu
authors.affiliation: Department of Medical Zoology, Kyung Hee University School of Medicine, Seoul 02447, Korea.
authors.forename: Sang-Soo
authors.initials: SS
authors.lastname: Kim
authors.affiliation: Department of Biomedical Science, Graduate School, Kyung Hee University, Seoul 02447, Korea.|Department of Medical Zoology, Kyung Hee University School of Medicine, Seoul 02447, Korea.
authors.forename: Su-Hwa
authors.initials: SH
authors.lastname: Lee
authors.affiliation: Department of Biomedical Science, Graduate School, Kyung Hee University, Seoul 02447, Korea.|Department of Medical Zoology, Kyung Hee University School of Medicine, Seoul 02447, Korea.
authors.forename: Dong-Hun
authors.initials: DH
authors.lastname: Lee
authors.affiliation: Department of Biomedical Science, Graduate School, Kyung Hee University, Seoul 02447, Korea.|Department of Medical Zoology, Kyung Hee University School of Medicine, Seoul 02447, Korea.
authors.forename: Ah-Ra
authors.initials: AR
authors.lastname: Kim
authors.affiliation: Department of Medical Zoology, Kyung Hee University School of Medicine, Seoul 02447, Korea.
authors.forename: Fu-Shi
authors.initials: FS
authors.lastname: Quan
mesh_terms: D000818:Animals; D000909:Antibodies, Helminth / Q000097:blood; D004195:Disease Models, Animal; D060467:Disease Resistance; D004804:Eosinophils / Q000276:immunology; D005260:Female; D007074:Immunoglobulin G / Q000097:blood; D008807:Mice, Inbred BALB C; D059208:Parasite Load; D017160:Trichinella spiralis / Q000276:immunology*; D014235:Trichinellosis / Q000276:immunology* / Q000517:prevention & control*
chemical_list: D000909:Antibodies, Helminth; D007074:Immunoglobulin G
keywords: CD23+ B cell; IgG; IgM+ B cell; Trichinella spiralis; eosinophil; resistance