title: Characterization of autism spectrum disorder with spontaneous hemodynamic activity.
abstract: Functional near-infrared spectroscopy (fNIRS) was used to investigate spontaneous hemodynamic activity in the temporal cortex for typically developing (TD) children and children with autism spectrum disorder (ASD). Forty-seven children participated in the experiments including twenty-five with ASD. Compared with TD children, children with ASD showed weaker bilateral resting-state functional connectivity (RSFC), but much stronger fluctuation magnitude in terms of oxy-hemoglobin (HbO2) and deoxy-hemoglobin (Hb). Differentiating between ASD and TD based on a support vector machine (SVM) model including bilateral RSFC and the fluctuation power of HbO2and Hb as variables could achieve high accurate classification with sensitivity of 81.6% and specificity of 94.6%. This study demonstrates optical brain imaging has the potential for screening children with risk of ASD.
authors.affiliation: South China Academy of Advanced Optoelectronics, South China Normal University, Guangzhou, 510006, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.affiliation: South China Academy of Advanced Optoelectronics, South China Normal University, Guangzhou, 510006, China; Dipartimento di Fisica, Politecnico di Milano, Milan, Italy.
authors.forename: Lina
authors.initials: L
authors.lastname: Qiu
authors.affiliation: School of Computer Engineering & Science, Shanghai University, Shanghai, 200072, China.
authors.forename: Lingyu
authors.initials: L
authors.lastname: Xu
authors.affiliation: Division of Child and Adolescent Psychiatry, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
authors.forename: Ernest V
authors.initials: EV
authors.lastname: Pedapati
authors.affiliation: Division of Child and Adolescent Psychiatry, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
authors.forename: Craig A
authors.initials: CA
authors.lastname: Erickson
authors.affiliation: Department of Biomedical, Industrial and Human Factors Engineering, Wright State University, Dayton, OH 45435, USA.
authors.forename: Ulas
authors.initials: U
authors.lastname: Sunar
keywords: (170.2655) Functional monitoring and imaging; (170.3880) Medical and biological imaging; (170.4580) Optical diagnostics for medicine