title: Chronic Alcohol Abuse Leads to Low Bone Mass with No General Loss of Bone Structure or Bone Mechanical Strength<sup/>.
abstract: Chronic alcohol abuse (CAA) has deleterious effects on skeletal health. This study examined the impact of CAA on bone with regard to bone density, structure, and strength. Bone specimens from 42 individuals with CAA and 42 individuals without alcohol abuse were obtained at autopsy. Dual-energy X-ray absorptiometry (DEXA), compression testing, ashing, and bone histomorphometry were performed. Individuals with CAA had significantly lower bone mineral density (BMD) in the femoral neck and significantly lower bone volume demonstrated by thinner trabeculae, decreased extent of osteoid surfaces, and lower mean wall thickness of trabecular osteons compared to individuals without alcohol abuse. No significant difference was found for bone strength and structure.
  
  
  
  CAA leads to low bone mass due to a decrease in bone formation but with no destruction of bone architecture nor a decrease in bone strength. It is questionable whether this per se increases fracture risk.
authors.affiliation: Department of Forensic Medicine, University of Aarhus, Palle Juul-Jensens Boulevard 99, DK-8200, Arhus N, Denmark.
authors.forename: Maiken Parm
authors.initials: MP
authors.lastname: Ulhøi
authors.affiliation: Department of Internal Medicine, Regional Hospital West Jutland, Gl. Landevej 61, DK-7400, Herning, Denmark.
authors.forename: Karoline
authors.initials: K
authors.lastname: Meldgaard
authors.affiliation: Institute of Pathology, Aarhus University Hospital, Noerrebrogade 44, DK-8000, Aarhus, Denmark.
authors.forename: Torben
authors.initials: T
authors.lastname: Steiniche
authors.affiliation: Department of Orthopaedics, Copenhagen University Hospital Gentofte, Kildegaardsvej 28, DK-2900, Hellerup, Denmark.
authors.forename: Anders
authors.initials: A
authors.lastname: Odgaard
authors.affiliation: Department of Forensic Medicine, University of Aarhus, Palle Juul-Jensens Boulevard 99, DK-8200, Arhus N, Denmark.
authors.forename: Annie
authors.initials: A
authors.lastname: Vesterby
mesh_terms: D015502:Absorptiometry, Photon; D000328:Adult; D000368:Aged; D000437:Alcoholism / Q000150:complications*; D015519:Bone Density; D016022:Case-Control Studies; D005260:Female; D005272:Femur Neck / Q000000981:diagnostic imaging / Q000473:pathology; D006253:Haversian System / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D007085:Ilium / Q000000981:diagnostic imaging / Q000473:pathology; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D008875:Middle Aged; D013314:Stress, Mechanical
keywords: bone histomorphometry; bone strength; bone structure; chronic alcohol abuse; forensic science; fracture risk; osteopenia; skeletal health