title: Statins and risk of breast cancer recurrence.
abstract: BACKGROUND
  The primary end point of our study was to test whether the concurrent use of a statin is related to a lower risk of recurrence and increased relapse-free survival in patients with early breast cancer.
  
  
  METHODS
  We reviewed 610 female patients with stage I, II, or III breast cancer who had been surgically treated and who had subsequently received at least adjuvant chemotherapy in order to prevent recurrence.
  
  
  RESULTS
  Among the 610 patients with breast cancer, 83 (13.6%) were receiving a statin on a chronic basis for other medical purposes. Overall, statin users displayed longer mean relapse-free survival (16.6 vs 10.2 years,P=0.028). After data had been adjusted for patient and disease characteristics, statin users maintained a lower risk of recurrence. This favorable outcome in statin users was particularly evident when we included only younger patients in the analysis (20 vs 10 years,P=0.006).
  
  
  CONCLUSIONS
  Statins may be linked to a favorable outcome in early breast cancer patients, especially in younger age-groups.
authors.affiliation: Department of Medicine, Division of Oncology, University Hospital, Patras Medical School, Patras.
authors.forename: Minas
authors.initials: M
authors.lastname: Sakellakis
authors.affiliation: Department of Medicine, Division of Oncology, University Hospital, Patras Medical School, Patras.
authors.forename: Karolina
authors.initials: K
authors.lastname: Akinosoglou
authors.affiliation: Department of Statistics, Athens University of Economics and Business, Athens, Greece.
authors.forename: Anastasia
authors.initials: A
authors.lastname: Kostaki
authors.affiliation: Department of Medicine, Division of Oncology, University Hospital, Patras Medical School, Patras.
authors.forename: Despina
authors.initials: D
authors.lastname: Spyropoulou
authors.affiliation: Department of Medicine, Division of Oncology, University Hospital, Patras Medical School, Patras.
authors.forename: Angelos
authors.initials: A
authors.lastname: Koutras
keywords: adjuvant; breast; cancer; recurrence; statins