title: A new cycloartane-type triterpenoid from the roots of Dianella ensifolia (L.) DC.
abstract: A new cycloartane-type triterpenoid, named 22-hydroxy-cyclolaudenol (1), together with two known cycloartane-type triterpenoids were isolated from the roots of Dianella ensifolia. Their structures were determined based on spectroscopic methods, including UV, IR, HR-ESI-MS, NMR and X-ray diffraction. Compound 1 displayed cytotoxic effects against cancer cell lines B16-F10, A549 and MDA-MB-231.
authors.affiliation: a Department of Medical Science , Shunde Polytechnic College , Shunde , China.
authors.forename: Ben-Qin
authors.initials: BQ
authors.lastname: Tang
authors.affiliation: b State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences , University of Macau , Macau SAR , China.
authors.forename: Chu-Wen
authors.initials: CW
authors.lastname: Li
authors.affiliation: c Department of Natural Medicinal Chemistry , China Pharmaceutical University , Nanjing , China.
authors.forename: Jian-Bo
authors.initials: JB
authors.lastname: Sun
authors.affiliation: b State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences , University of Macau , Macau SAR , China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Chang
authors.affiliation: b State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences , University of Macau , Macau SAR , China.
authors.forename: Judy Yuet-Wa
authors.initials: JY
authors.lastname: Chan
authors.affiliation: b State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences , University of Macau , Macau SAR , China.
authors.forename: Simon Ming-Yuan
authors.initials: SM
authors.lastname: Lee
authors.affiliation: a Department of Medical Science , Shunde Polytechnic College , Shunde , China.
authors.forename: Bao
authors.initials: B
authors.lastname: Zeng
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D056945:Hep G2 Cells / Q000187:drug effects; D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry; D006801:Humans; D020128:Inhibitory Concentration 50; D061986:MCF-7 Cells / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D019684:Magnoliopsida / Q000737:chemistry*; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet; D013256:Steroids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification; D014961:X-Ray Diffraction
chemical_list: C000619551:22-hydroxy-cyclolaudenol; D000972:Antineoplastic Agents, Phytogenic; D006576:Heterocyclic Compounds, 4 or More Rings; D013256:Steroids; D014315:Triterpenes; C504155:cycloneolitsol; C540480:pholidonone; C085352:cycloartane
keywords: Cycloartane-type triterpenoids; Dianella ensifolia; cytotoxicity