title: Assessment of macrovascular endothelial function using pulse wave analysis and its association with microvascular reactivity in healthy subjects.
abstract: BACKGROUND
  Pulse wave analysis (PWA) and laser Doppler fluximetry (LDF) are non-invasive methods of assessing macrovascular endothelial function and microvascular reactivity respectively. The aim of this study was to assess the correlation between macrovascular endothelial function assessed by PWA and microvascular reactivity assessed by LDF.
  
  
  METHODS
  297 healthy and non-smoking subjects (159 females, mean age (±SD) 23.56 ± 4.54 years) underwent microvascular reactivity assessment using LDF followed by macrovascular endothelial function assessments using PWA.
  
  
  RESULTS
  Pearson's correlation showed no correlation between macrovascular endothelial function and microvascular reactivity (r = -0.10, P = 0.12).
  
  
  CONCLUSIONS
  There was no significant correlation between macrovascular endothelial function assessed by PWA and microvascular reactivity assessed by LDF in healthy subjects.
authors.affiliation: Department of Pharmacology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Malaysia.
authors.forename: N N I N
authors.identifier: http://orcid.org/0000-0002-9817-1574
authors.initials: NNIN
authors.lastname: Ibrahim
authors.affiliation: Department of Pharmacology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Malaysia.
authors.forename: A H G
authors.initials: AHG
authors.lastname: Rasool
mesh_terms: D058666:Adrenergic beta-2 Receptor Agonists / Q000494:pharmacology; D000328:Adult; D000420:Albuterol / Q000494:pharmacology; D003430:Cross-Sectional Studies; D004730:Endothelium, Vascular / Q000000981:diagnostic imaging* / Q000187:drug effects / Q000503:physiopathology; D005260:Female; D005542:Forearm / Q000098:blood supply* / Q000503:physiopathology; D006801:Humans; D006940:Hyperemia / Q000503:physiopathology; D017078:Laser-Doppler Flowmetry / Q000379:methods; D008297:Male; D055806:Microvessels / Q000000981:diagnostic imaging* / Q000187:drug effects / Q000503:physiopathology; D063177:Pulse Wave Analysis / Q000379:methods*; D012867:Skin / Q000098:blood supply* / Q000503:physiopathology
chemical_list: D058666:Adrenergic beta-2 Receptor Agonists; D000420:Albuterol
keywords: endothelial function; macrovascular; microvascular; post occlusive forearm skin reactive hyperemia; pulse wave analysis