title: Mitochondria-targeted nutraceuticals in sports medicine: a new perspective.
abstract: Since mitochondria have been recognized as the cells' key organelles involved in the energy utilization during exercise, targeting the organelle with specifically designed compounds (mitochondria-targeted nutraceuticals, MTNs) may have a great promise in the prevention and treatment of heavy exercise-related mitochondrial dysfunction. In vitro studies suggested that MTNs have antioxidant effects at the molecular level, and might boost mitochondrial biogenesis and organelle bioenergetics, with both processes are known to positively affect exercise performance and recovery. However, while there are a number of different MTNs evaluated for a potential benefit as a therapy for mitochondria-related diseases and conditions, only few human studies evaluated the possible impact of novel MTNs in the field of sports medicine. This mini review summarizes recent research findings regarding the efficacy of different mitochondria-targeted nutritional agents, emphasizing their roles in sports medicine.
authors.affiliation: a Faculty of Sport and Physical Education , University of Novi Sad , Novi Sad , Serbia.|b University of Belgrade School of Medicine , Belgrade , Serbia.
authors.forename: Sergej M
authors.initials: SM
authors.lastname: Ostojic
mesh_terms: D000975:Antioxidants / Q000494:pharmacology*; D054874:Athletic Performance / Q000502:physiology; D019587:Dietary Supplements; D015444:Exercise / Q000502:physiology*; D006801:Humans; D008928:Mitochondria / Q000187:drug effects* / Q000502:physiology; D058573:Performance-Enhancing Substances / Q000494:pharmacology*; D013177:Sports / Q000502:physiology*; D013178:Sports Medicine
chemical_list: D000975:Antioxidants; D058573:Performance-Enhancing Substances
keywords: Mitochondrial dysfunction; exercise; quercetin; resveratrol; small molecule antioxidants