title: Characteristics of primary Sjögren's syndrome patients with IgG4 positive plasma cells infiltration in the labial salivary glands.
abstract: The purpose of this study was to investigate the characteristics of primary Sjögren's syndrome (pSS) patients with IgG4 positive (IgG4+) plasma cell infiltration in labial salivary glands (LSGs). Paraffin sections of LSGs from 336 pSS patients were stained with IgG4 and IgG monoclonal antibodies. According to the infiltration of IgG4+plasma cells, patients were divided and clinical and serological characteristics were analyzed and compared. Based on the infiltration of IgG4+plasma cells in the LSGs, patients were divided into three subgroups, low IgG4, moderate IgG4, and high IgG4 groups. A negative association between the number of infiltrated IgG4+plasma cells and the disease characteristics was observed. We found that the higher the IgG4+expression in plasma cells, the lower the positive rates of serum anti-SSA antibodies, anti-SSB antibodies, antinuclear antibodies (ANA), and rheumatoid factor (RF). Besides, patients from the high IgG4 group had the highest frequency of interstitial lung disease (ILD, 30.6%) and tubulointerstitial nephritis (TIN, 13.9%), but the lowest frequency of leucopenia (13.9%), thrombocytopenia (11.1%), and abnormal thyroidal function (0%). PSS patients with different IgG4+plasma cells infiltration in the LSGs had distinctive clinical and laboratory characteristics. It may help us to further understand the role of IgG4+plasma cells in pSS.
authors.affiliation: Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing Medical University, Nanjing, 210008, China.|Department of Rheumatology and Immunology, Dalian Municipal Central Hospital, Dalian, China.
authors.forename: Chang
authors.initials: C
authors.lastname: Liu
authors.affiliation: Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing Medical University, Nanjing, 210008, China.
authors.forename: Huayong
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing Medical University, Nanjing, 210008, China.
authors.forename: Genhong
authors.initials: G
authors.lastname: Yao
authors.affiliation: Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing Medical University, Nanjing, 210008, China.
authors.forename: Yunxia
authors.initials: Y
authors.lastname: Hu
authors.affiliation: Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing Medical University, Nanjing, 210008, China.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Qi
authors.affiliation: Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing Medical University, Nanjing, 210008, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing Medical University, Nanjing, 210008, China.
authors.forename: Weiwei
authors.initials: W
authors.lastname: Chen
authors.affiliation: Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing Medical University, Nanjing, 210008, China.
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Tang
authors.affiliation: Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing Medical University, Nanjing, 210008, China.
authors.forename: Wenchao
authors.initials: W
authors.lastname: Li
authors.affiliation: Department of Pathology and Center of Infection and Immunology, The University of Hong Kong, Hong Kong, China.
authors.forename: Liwei
authors.initials: L
authors.lastname: Lu
authors.affiliation: Department of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing, Jiangsu, 210029, China. lgu@njmu.edu.cn.
authors.forename: Luo
authors.initials: L
authors.lastname: Gu
authors.affiliation: Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing Medical University, Nanjing, 210008, China. lingyunsun@nju.edu.cn.
authors.forename: Lingyun
authors.initials: L
authors.lastname: Sun
mesh_terms: D000328:Adult; D000974:Antibodies, Antinuclear / Q000097:blood; D001327:Autoimmune Diseases; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000737:chemistry*; D007150:Immunohistochemistry; D007249:Inflammation; D008297:Male; D008875:Middle Aged; D010950:Plasma Cells / Q000166:cytology*; D012189:Retrospective Studies; D012217:Rheumatoid Factor / Q000097:blood; D012470:Salivary Glands, Minor / Q000166:cytology*; D012859:Sjogren's Syndrome / Q000276:immunology*
chemical_list: D000974:Antibodies, Antinuclear; D007074:Immunoglobulin G; D012217:Rheumatoid Factor
keywords: IgG4-positive plasma cells; IgG4-related diseases; Primary Sjögren’s syndrome