title: [Research Progress of Exosomes in Lung Cancer Diagnosis and Treatment].
abstract: As the leading cause of morbidity and cancer related-death worldwide, lung cancer has a serious threat to human health. Exosomes are nanoscale lipid membrane vesicles derived from multivesicles, which containing active biomolecules including proteins, lipids, nucleic acids and etc. Exosomes play important roles in lung cancer initiation and progression by promoting the formation of tumor microenvironment, enhancing tumor invasive and metastasis capability, leading to immunosuppression and resistance to chemoradiotherapy, and also have the application value in early diagnosis and treatment. This review summarizes the research progress of exosomes in tumor initiation and progression, and its roles in diagnosis and treatment of lung cancer.
authors.affiliation: The Affiliated Hospital of Southwest Medical University, Luzhou 646000, China;Department of Oncology, Chengdu Military  General Hospital, Chengdu 610083, China.
authors.forename: Hongbo
authors.initials: H
authors.lastname: Zou
authors.affiliation: The Affiliated Hospital of Southwest Medical University, Luzhou 646000, China;Guangxi Medical University, Nanning 530021, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Wu
authors.affiliation: The Affiliated Hospital of Southwest Medical University, Luzhou 646000, China;Department of Oncology, Chengdu Military  General Hospital, Chengdu 610083, China.
authors.forename: Chuan
authors.initials: C
authors.lastname: Xu
mesh_terms: D018450:Disease Progression; D055354:Exosomes / Q000378:metabolism*; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000628:therapy; D059016:Tumor Microenvironment