title: Expression of IL-1α and IL-6 is Associated with Progression and Prognosis of Human Cervical Cancer.
abstract: BACKGROUND IL-1α and IL-6 are associated with the prognosis of a wide range of cancers, but their value in cervical cancer remains controversial. The aim of this study was to investigate the expression of IL-1α and IL-6 in cervical cancer and their significance in clinical prognosis. MATERIAL AND METHODS The expression of IL-1α and IL-6 in 105 formalin-fixed, paraffin-embedded cervical cancer tissues and adjacent non-tumor tissues was examined by immunohistochemistry. The results were semi-quantitatively scored and analyzed by chi-square test. Patient overall survival (OS) data was collected by follow-up and analyzed by Kaplan-Meier analysis. RESULTS The expression level of both IL-1α and IL-6 in cervical cancer tissue was higher than in adjacent non-tumor tissues (p<0.05). IL-1α expression was shown to be correlated with tumor size, FIGO histology grade, lymph node metastasis, stromal invasion, and tumor differentiation (p<0.05). IL-6 expression was shown to be correlated with tumor size, FIGO histology grade, and tumor differentiation (p<0.05). Patients with positive expression of IL-1α or IL-6 tended to have much shorter survival times than patients with negative expression. In addition, a multivariate Cox regression analysis demonstrated that IL-1α expression and lymph node metastasis were independent predictors of OS in cervical cancer patients. CONCLUSIONS The expression of IL-1α was significantly associated with tumor size, FIGO histology grade, lymph node metastasis, stromal invasion, and tumor differentiation. The expression of IL-6 was significantly associated with tumor size, FIGO histology grade, and tumor differentiation. Positive IL-1α and IL-6 expression was significantly correlated with poor prognosis. They may be considered valuable biomarkers for prognosis and potential therapeutic targets for cervical cancer.
authors.affiliation: Breast Cancer Center, Shanghai East Hospital, Tongji University, Shanghai, China (mainland).
authors.forename: Zhiwang
authors.initials: Z
authors.lastname: Song
authors.affiliation: Breast Cancer Center, Shanghai East Hospital, Tongji University, Shanghai, China (mainland).
authors.forename: Yun
authors.initials: Y
authors.lastname: Lin
authors.affiliation: Breast Cancer Center, Shanghai East Hospital, Tongji University, Shanghai, China (mainland).
authors.forename: Xiaojuan
authors.initials: X
authors.lastname: Ye
authors.affiliation: Breast Cancer Center, Shanghai East Hospital, Tongji University, Shanghai, China (mainland).
authors.forename: Chan
authors.initials: C
authors.lastname: Feng
authors.affiliation: Breast Cancer Center, Shanghai East Hospital, Tongji University, Shanghai, China (mainland).
authors.forename: Yonglin
authors.initials: Y
authors.lastname: Lu
authors.affiliation: Breast Cancer Center, Shanghai East Hospital, Tongji University, Shanghai, China (mainland).
authors.forename: Guang
authors.initials: G
authors.lastname: Yang
authors.affiliation: Breast Cancer Center, Shanghai East Hospital, Tongji University, Shanghai, China (mainland).
authors.forename: Chunyan
authors.initials: C
authors.lastname: Dong
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000096:biosynthesis* / Q000235:genetics; D018450:Disease Progression; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053582:Interleukin-1alpha / Q000096:biosynthesis* / Q000235:genetics; D015850:Interleukin-6 / Q000096:biosynthesis* / Q000235:genetics; D053208:Kaplan-Meier Estimate; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D002583:Uterine Cervical Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; C508584:IL1A protein, human; C508600:IL6 protein, human; D053582:Interleukin-1alpha; D015850:Interleukin-6