title: Mortality markers in nosocomialKlebsiella pneumoniaebloodstream infection.
abstract: OBJECTIVE
  Klebsiella pneumoniaeis the most common endogen agent for nosocomial infections. In this study, mortality markers were investigated in patients with nosocomialK. pneumoniaeblood stream infection (NKp BSI).
  
  
  METHODS
  The characteristics of patients >16 years who had NKp BSI diagnosis by daily active surveillance between January 2012 and January 2016 were retrospectively evaluated. Patients who died until 28th day of the clinical follow up and those who survived until this time were statistically compared in terms of various risk factors.
  
  
  RESULTS
  One hundred ninety patients were included into the study. Mortality rate was 47.9%, carbapenem resistance was 43.2%. Statistical analysis have shown that in presence of post-NKp BSI sepsis, septic shock, following in intensive care unit (ICU), meropenem resistance, kidney failure, NKp BSI secondary to pneumonia, use of invasive instruments such as central venous catheter (CVC), urinary catheter (UC) and mechanical ventilator (MV), colostomy, transfusion and hemodialysis mortality was significantly higher. In patients admitted into the hospital for neurological disorders, pancreaticobiliary tract (PBT) diseases and patients who have undergone endoscopic retrograde cholangiopancreatography (ERCP) and patients in whom NKp BSI secondary to PBT infection mortality rate was lower.
  
  
  CONCLUSIONS
  Sepsis, septic shock, clinical conditions requiring ICU treatment and meropenem resistance increase mortality rates in NKp BSI significantly. Mortality was higher also in patients with NKp BSI secondary to pneumonia, in kidney failure and when invasive instruments were used. On the other hand, in patients who were admitted to the hospital for neurological disorders and PBT diseases mortality rate was lower.
authors.affiliation: Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Bezmialem Vakif University, Adnan Menderes Boulevard, Fatih, 34093 Istanbul, Turkey.
authors.forename: Bulent
authors.initials: B
authors.lastname: Durdu
authors.affiliation: Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Bezmialem Vakif University, Adnan Menderes Boulevard, Fatih, 34093 Istanbul, Turkey.
authors.forename: Ismail Necati
authors.initials: IN
authors.lastname: Hakyemez
authors.affiliation: Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Bezmialem Vakif University, Adnan Menderes Boulevard, Fatih, 34093 Istanbul, Turkey.
authors.forename: Sibel
authors.initials: S
authors.lastname: Bolukcu
authors.affiliation: Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Bezmialem Vakif University, Adnan Menderes Boulevard, Fatih, 34093 Istanbul, Turkey.
authors.forename: Gulay
authors.initials: G
authors.lastname: Okay
authors.affiliation: Department of Microbiology and Clinical Microbiology, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey.
authors.forename: Bilge
authors.initials: B
authors.lastname: Gultepe
authors.affiliation: Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Bezmialem Vakif University, Adnan Menderes Boulevard, Fatih, 34093 Istanbul, Turkey.
authors.forename: Turan
authors.initials: T
authors.lastname: Aslan