title: Possible antioxidant effect of Lycium barbarum polysaccharides on hepatic cadmium-induced oxidative stress in rats.
abstract: The aim of this study was to investigate the potential protective effect of Lycium barbarum polysaccharides (LBP) pretreatment against cadmium (Cd)-induced hepatotoxicity in rats. Wistar rats were divided into control group, LBP group (300 mg/kg orally, once a day, for 30 days), Cd group (CdCl24 mg/kg i.p. once), and LBP + Cd group (LBP 300 mg/kg orally, once a day, for 30 days + CdCl24 mg/kg i.p. 24 h after the last treatment). Cd liver injury was examined by morphological/histological changes, transaminases, total protein concentration, and oxidative stress evaluated by MDA, 3NT, GSH, SOD, and TEAC activities. Cd intoxication caused gross morphological changes with hyperemia of the parenchyma, increased volume, and disappearance of the anatomical limits of the lobes associated with an increase of ALT, GSH, and TEAC in plasma and a decrease of MDA, GSH, and TEAC in liver, SOD, and total proteins in plasma. LBP pretreatment caused a slight improvement in the histological architecture and in the 3NT amount together with a significant improvement of hematic parameters. On the basis of the obtained results, we can affirm that LBP pretreatment can ameliorate liver conditions, but further studies are needed to better evaluate the protective antioxidant effects of LBP against Cd-induced toxicity.
authors.affiliation: Department of Veterinary Medicine, University of Sassari, via Vienna 2, 07100, Sassari, Italy.
authors.forename: Maria Vittoria
authors.initials: MV
authors.lastname: Varoni
authors.affiliation: Department of Veterinary Medicine, University of Sassari, via Vienna 2, 07100, Sassari, Italy.
authors.forename: Valeria
authors.initials: V
authors.lastname: Pasciu
authors.affiliation: Department of Veterinary Medicine, University of Sassari, via Vienna 2, 07100, Sassari, Italy.
authors.forename: Sergio Domenico
authors.initials: SD
authors.lastname: Gadau
authors.affiliation: Department of Veterinary Medicine, University of Sassari, via Vienna 2, 07100, Sassari, Italy. ebaralla@uniss.it.
authors.forename: Elena
authors.initials: E
authors.lastname: Baralla
authors.affiliation: Department of Veterinary Medicine, University of Sassari, via Vienna 2, 07100, Sassari, Italy.
authors.forename: Elisa
authors.initials: E
authors.lastname: Serra
authors.affiliation: Department of Veterinary Medicine, University of Sassari, via Vienna 2, 07100, Sassari, Italy.
authors.forename: Domenico
authors.initials: D
authors.lastname: Palomba
authors.affiliation: Department of Veterinary Medicine, University of Sassari, via Vienna 2, 07100, Sassari, Italy.
authors.forename: Maria Piera
authors.initials: MP
authors.lastname: Demontis
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002104:Cadmium; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D008099:Liver / Q000378:metabolism; D032305:Lycium; D008297:Male; D018384:Oxidative Stress; D011134:Polysaccharides / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000975:Antioxidants; D004365:Drugs, Chinese Herbal; D011134:Polysaccharides; C500223:lycium barbarum polysaccharide; D002104:Cadmium
keywords: 3-Nitro-L-tyrosine; Cadmium; Liver; Lycium barbarum polysaccharides; Oxidative stress