title: Protein tyrosine phosphatase nonreceptor type 22 (PTPN22) gene polymorphism in pulmonary tuberculosis in the Indian population.
abstract: A variant of the protein tyrosine phosphatase nonreceptor type 22 (PTPN22) gene is known to be associated with susceptibility to autoimmune diseases and bacterial infections as it acts as an important regulator of T-cell activation. The objective of this study was to evaluate whether PTPN22-C1858T polymorphism is associated with the resistance to pulmonary tuberculosis (PTB). Single-nucleotide polymorphism of PTPN22-C1858T (rs2476601) was genotyped in 124 patients with PTB and 130 healthy controls from India using restriction fragment length polymorphism and direct sequencing of the amplified DNA. The frequencies of genotypes CC, CT, and TT were 100%, 0%, and 0%, respectively, in PTB; and 99.2%, 0.8% and 0%, respectively, in healthy control individuals. These values did not differ significantly between the patients and controls. The mutant allele C1858T was found to be a rare allele in Indian population.
authors.affiliation: Department of Zoology, Yogi Vemana University, Kadapa, Andhra Pradesh, India.
authors.forename: Vydyanath R
authors.initials: VR
authors.lastname: Narasimha
authors.affiliation: Department of Biotechnology, Government College for Men, Kadapa, Andhra Pradesh, India.
authors.forename: Kalpana
authors.initials: K
authors.lastname: Panati
authors.affiliation: Jayalakshmi Memorial Chest Hospital, Kadapa, Andhra Pradesh, India.
authors.forename: M Gangadhara
authors.initials: MG
authors.lastname: Reddy
authors.affiliation: Department of Zoology, Yogi Vemana University, Kadapa, Andhra Pradesh, India. Electronic address: nvramireddy@gmail.com.
authors.forename: Venkata Ramireddy
authors.initials: VR
authors.lastname: Narala
mesh_terms: D000328:Adult; D060467:Disease Resistance; D005260:Female; D005787:Gene Frequency; D060005:Genotyping Techniques; D006801:Humans; D007194:India; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D054596:Protein Tyrosine Phosphatase, Non-Receptor Type 22 / Q000235:genetics*; D017422:Sequence Analysis, DNA; D014397:Tuberculosis, Pulmonary / Q000235:genetics*
chemical_list: C516765:PTPN22 protein, human; D054596:Protein Tyrosine Phosphatase, Non-Receptor Type 22
keywords: PTPN22; Pulmonary tuberculosis; Single-nucleotide polymorphism