title: Lower Bmi-1 Expression May Predict Longer Survival of Colon Cancer Patients.
abstract: BACKGROUND
  This study aimed to investigate the Bmi-1 expression and the clinical significance in colon cancer (CC).
  
  
  METHODS
  Bmi-1 expression in tumor tissue and the corresponding normal tissue was detected using immunohistological staining. The correlations between Bmi-1 expression and clinicopathological characteristics and the overall survival (OS) time were analyzed.
  
  
  RESULTS
  The median H-scores of Bmi-1 in CC tissues and the corresponding tissues were 80.0 (0-270) and 5.0 (0-90), with no statistically significant difference (Z=-13.7, P<0.001). Bmi-1 expression in CC tissues was not statistically correlated with any characteristics. The median OS times for CC patients with high or low Bmi-1 expression were 53.7 months and 44.9 months, respectively, with no statistically significant difference (P = 0.123). The survival rates of patients with low Bmi-1 expression were higher than those of patients with high Bmi-1 expression but the differences were not statistically significant.
  
  
  CONCLUSIONS
  Bmi-1 expression in CC tissue is significantly higher than that in corresponding normal tissue. While there may be a trend towards improved survival, this is not statistically significant.
authors.affiliation: Department of Oncology, The Third Affiliated Hospital of Soochow University, Changzhou, (P. R. China).
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Li
authors.forename: Xiao
authors.initials: X
authors.lastname: Zheng
authors.forename: Bin
authors.initials: B
authors.lastname: Xu
authors.forename: Dachuan
authors.initials: D
authors.lastname: Zhang
authors.forename: Yun
authors.initials: Y
authors.lastname: Xu
authors.forename: Quanqin
authors.initials: Q
authors.lastname: Xie
authors.forename: Wenwei
authors.initials: W
authors.lastname: Hu
authors.forename: Zhuojun
authors.initials: Z
authors.lastname: Zheng
authors.forename: Yingjie
authors.initials: Y
authors.lastname: Shao
authors.forename: Jun
authors.initials: J
authors.lastname: Wu
authors.forename: Mei
authors.initials: M
authors.lastname: Ji
authors.forename: Jingting
authors.initials: J
authors.lastname: Jiang
authors.forename: Changping
authors.initials: C
authors.lastname: Wu
mesh_terms: D000368:Aged; D003110:Colonic Neoplasms / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D063150:Polycomb Repressive Complex 1 / Q000378:metabolism*; D016019:Survival Analysis; D015996:Survival Rate
chemical_list: C069077:BMI1 protein, human; D063150:Polycomb Repressive Complex 1