title: The Janus face of p21.
abstract: Accumulating data support the bimodal action of several key cellular factors in cancer. The dogma of p21WAF1/Cip1as a tumor suppressor has been recently challenged since new data support its tumor promoting features depending on the tumor environment. Here we discuss the Janus face of p21WAF1/Cip1.
authors.affiliation: Molecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National and Kapodistrian University of Athens , Athens, Greece.
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Evangelou
authors.affiliation: Molecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National and Kapodistrian University of Athens , Athens, Greece.
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Galanos
authors.affiliation: Molecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National and Kapodistrian University of Athens, Athens, Greece; Faculty Institute for Cancer Sciences, Manchester Academic Health Sciences Center, University of Manchester, Manchester, UK; Biomedical Research Foundation, Academy of Athens, Athens, Greece.
authors.forename: Vassilis G
authors.initials: VG
authors.lastname: Gorgoulis
keywords: Genomic instability; PCNA; p21WAF1/Cip1; p53; replication stress; tumor heterogeneity 