title: The assessment of mucosal surgical margins in head and neck cancer surgery with narrow band imaging.
abstract: The diagnostic gain of narrow band imaging in the definition of surgical margins in the treatment of head and neck cancer was evaluated.
  
  
  
  A prospective study, blinded to the pathologist, with historical comparison.
  
  
  
  The study group included 45 patients subjected to the intraoperative definition of margins by narrow band imaging. The control group included 55 patients who had undergone standard definition of margins. All patients underwent resection of the tumor and frozen section analysis of superficial margins. The rate of initial R0resection and the ratio of histologically negative margins for both groups were statistically compared.
  
  
  
  The rate of initial R0resection in the study group and in the control group was 88.9% and 70.9% (P = .047), and the ratio of histologically negative margins was 95.9% and 88.4% (P = .017), respectively.
  
  
  
  Narrow band imaging reveals a microscopic extension of the tumor that could be effectively used to better define superficial margins and to achieve a higher rate of initial R0resections.
  
  
  
  4 Laryngoscope, 127:1577-1582, 2017.
authors.affiliation: Department of Otorhinolaryngology and Cervicofacial Surgery, University Medical Center Ljubljana, Ljubljana, Slovenia.
authors.forename: Robert
authors.initials: R
authors.lastname: Šifrer
authors.affiliation: Department of Otorhinolaryngology and Cervicofacial Surgery, University Medical Center Ljubljana, Ljubljana, Slovenia.
authors.forename: Jure
authors.initials: J
authors.lastname: Urbančič
authors.affiliation: Institute of Oncology, Ljubljana, Slovenia.
authors.forename: Primož
authors.initials: P
authors.lastname: Strojan
authors.affiliation: Department of Otorhinolaryngology and Cervicofacial Surgery, University Medical Center Ljubljana, Ljubljana, Slovenia.
authors.forename: Aleksandar
authors.initials: A
authors.lastname: Aničin
authors.affiliation: Department of Otorhinolaryngology and Cervicofacial Surgery, University Medical Center Ljubljana, Ljubljana, Slovenia.
authors.forename: Miha
authors.initials: M
authors.lastname: Žargi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005629:Frozen Sections; D006801:Humans; D008297:Male; D000072662:Margins of Excision; D008875:Middle Aged; D009092:Mucous Membrane / Q000473:pathology*; D062048:Narrow Band Imaging; D010039:Otorhinolaryngologic Neoplasms / Q000473:pathology* / Q000601:surgery*; D011446:Prospective Studies; D012680:Sensitivity and Specificity
keywords: Surgical margins; frozen section; head and neck cancer; narrow band imaging