title: Different Supplementation Regimes to Treat Perioperative Vitamin B12 Deficiencies in Bariatric Surgery: a Systematic Review.
abstract: Vitamin B12 dosage in multivitamin supplementation in the current literature is quite variable. There is no consensus about the optimal treatment of vitamin B12 deficiency. A systematic literature search on different supplementation regimes to treat perioperative vitamin B12 deficiencies in bariatric surgery was performed. The methodological quality of ten included studies was rated using the Newcastle Ottawa scale and ranged from moderate to good. The agreement between the reviewers was assessed with a Cohen's kappa (0.69). The current literature suggests that 350 μg oral vitamin B12 is the appropriate dose to correct low vitamin B12 levels in many patients. Further research must focus on a better diagnosis of a vitamin B12 deficiency, the optimal dose vitamin B12 supplementation, and clinical relevance next to biochemical data.
authors.affiliation: Department of Nutrition, Catharina Hospital, Eindhoven, The Netherlands. marieke.smelt@catharinaziekenhuis.nl.|Obesity Center, Catharina Hospital, Eindhoven, The Netherlands. marieke.smelt@catharinaziekenhuis.nl.
authors.forename: H J M
authors.initials: HJ
authors.lastname: Smelt
authors.affiliation: Department of Surgery, Catharina Hospital, Eindhoven, The Netherlands.|Obesity Center, Catharina Hospital, Eindhoven, The Netherlands.
authors.forename: S
authors.initials: S
authors.lastname: Pouwels
authors.affiliation: Department of Surgery, Catharina Hospital, Eindhoven, The Netherlands.|Obesity Center, Catharina Hospital, Eindhoven, The Netherlands.
authors.forename: J F
authors.initials: JF
authors.lastname: Smulders
mesh_terms: D050110:Bariatric Surgery; D019587:Dietary Supplements; D006801:Humans; D009767:Obesity, Morbid / Q000150:complications / Q000178:diet therapy* / Q000453:epidemiology / Q000601:surgery*; D019990:Perioperative Care / Q000379:methods*; D059035:Perioperative Period; D014805:Vitamin B 12 / Q000008:administration & dosage*; D014806:Vitamin B 12 Deficiency / Q000150:complications / Q000178:diet therapy* / Q000453:epidemiology / Q000601:surgery*
chemical_list: D014805:Vitamin B 12
keywords: Bariatric surgery; Methylmalonic acid; Vitamin B12 deficiency; Vitamin B12 supplementation