title: [Analysis of minocycline hydrochloride combined with Vitapex in treating senile chronic periodontal-endodontic combined lesions].
abstract: OBJECTIVE
  To investigate the effect of minocycline hydrochloride combined with Vitapex in treating senile chronic periodontal-endodontic combined lesions.
  
  
  METHODS
  One hundred twenty patients with senile chronic periodontitis and endodontic lesions patients treated in our hospital between Jun.2012 to Jun.2014 were selected. They were divided into experimental group (n=60) and control group (n=60). Patients in the control group were given conventional root canal therapy, while patients in the experimental group were given Vitapex and minocycline hydrochloride. The clinical effect between two groups was compared. SPSS18.0 software package was used for statistical analysis.
  
  
  RESULTS
  Compared with pre-treatment, the levels of IL-17, TNF-α and CRP in serum were decreased in two groups, but the levels in the experimental group were significantly lower than those in the control group(P<0.05). Compared with pre-treatment, PD, GI, BI, PLI were decreased in two groups, but the levels in the experimental group were significantly lower than those in the control group(P<0.05). The effective rate of experimental group was 83.33% and the control group was 68.33%, the difference was statistically significant (P<0.05).
  
  
  CONCLUSIONS
  For chronic periodontitis and endodontic lesions, besides conventional root canal therapy, Vitapex combined with minocycline hydrochloride can significantly improve the clinical effect.
authors.affiliation: Department of Stomatology, The Affilated 81 Hospital of Nanjing University of Chinese Medicine. Nanjing 210002, Jiangsu Province, China. E-mail:285704914@qq.com.
authors.forename: Zhen-Yu
authors.initials: ZY
authors.lastname: Liu
authors.forename: Jing-Dong
authors.initials: JD
authors.lastname: Zhang
authors.forename: Lin
authors.initials: L
authors.lastname: Zhang
authors.forename: Jian
authors.initials: J
authors.lastname: Yang
authors.forename: Xiang-Hui
authors.initials: XH
authors.lastname: Liu
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002126:Calcium Hydroxide / Q000627:therapeutic use*; D055113:Chronic Periodontitis / Q000628:therapy*; D012534:Dental Scaling; D006801:Humans; D020381:Interleukin-17; D008911:Minocycline / Q000627:therapeutic use*; D012387:Root Canal Filling Materials / Q000627:therapeutic use; D012390:Root Canal Therapy; D012828:Silicones / Q000627:therapeutic use*; D014409:Tumor Necrosis Factor-alpha
chemical_list: D000900:Anti-Bacterial Agents; C508717:IL17A protein, human; D020381:Interleukin-17; D012387:Root Canal Filling Materials; D012828:Silicones; D014409:Tumor Necrosis Factor-alpha; C029584:calcium hydroxide, iodoform, silicone oil drug combination; D008911:Minocycline; D002126:Calcium Hydroxide