title: Mechanical Stress Regulates Bone Metabolism Through MicroRNAs.
abstract: There are many lines of evidence indicating that mechanical stress regulates bone metabolism and promotes bone growth. BMP, Wnt, ERK1/2, and OPG/RANKL are the main molecules thought to regulate the effects of mechanical loading on bone formation. Recently, microRNAs were found to be involved in bone cell proliferation and differentiation, regulating the balance of bone formation and bone resorption. Emerging evidence indicates that microRNAs also participate in mechanical stress-mediated bone metabolism, and is associated with disuse induced osteoporosis or osteopenia. Mechanical stress is able to induce expression of microRNAs that modulate the expression of osteogenic and bone resorption factors, leading to the positive impact of mechanical stress on bone. This review discusses the emerging evidence implicating an important role for microRNAs in the mechanical stress response in bone cells, as well as the challenges of translating microRNA research into potential treatment. J. Cell. Physiol. 232: 1239-1245, 2017. © 2016 Wiley Periodicals, Inc.
authors.affiliation: School of Kinesiology, Shanghai University of Sport, Shanghai, P. R. China.|School of Pathology and Laboratory Medicine, the University of Western Australia, Perth, Western Australia, Australia.
authors.forename: Yu
authors.initials: Y
authors.lastname: Yuan
authors.affiliation: School of Kinesiology, Shanghai University of Sport, Shanghai, P. R. China.
authors.forename: Lingli
authors.initials: L
authors.lastname: Zhang
authors.affiliation: School of Kinesiology, Shanghai University of Sport, Shanghai, P. R. China.
authors.forename: Xiaoyang
authors.initials: X
authors.lastname: Tong
authors.affiliation: School of Kinesiology, Shanghai University of Sport, Shanghai, P. R. China.
authors.forename: Miao
authors.initials: M
authors.lastname: Zhang
authors.affiliation: School of Kinesiology, Shanghai University of Sport, Shanghai, P. R. China.
authors.forename: Yilong
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: School of Kinesiology, Shanghai University of Sport, Shanghai, P. R. China.
authors.forename: Jianming
authors.initials: J
authors.lastname: Guo
authors.affiliation: School of Kinesiology, Shanghai University of Sport, Shanghai, P. R. China.
authors.forename: Le
authors.initials: L
authors.lastname: Lei
authors.affiliation: School of Kinesiology, Shanghai University of Sport, Shanghai, P. R. China.|School of Sports Science, Wenzhou Medical University, Wenzhou, China.
authors.forename: Xi
authors.initials: X
authors.lastname: Chen
authors.affiliation: School of Pathology and Laboratory Medicine, the University of Western Australia, Perth, Western Australia, Australia.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Tickner
authors.affiliation: School of Kinesiology, Shanghai University of Sport, Shanghai, P. R. China.|School of Pathology and Laboratory Medicine, the University of Western Australia, Perth, Western Australia, Australia.
authors.forename: Jiake
authors.initials: J
authors.lastname: Xu
authors.affiliation: School of Kinesiology, Shanghai University of Sport, Shanghai, P. R. China.
authors.forename: Jun
authors.initials: J
authors.lastname: Zou
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000378:metabolism*; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*; D008954:Models, Biological; D010012:Osteogenesis / Q000235:genetics; D015398:Signal Transduction / Q000235:genetics; D013314:Stress, Mechanical
chemical_list: D035683:MicroRNAs