title: Two different "tales" of ATG7: Clinical relevance to myelodysplastic syndromes.
abstract: Somatic mutations in U2 Small Nuclear RNA Auxiliary Factor 1 (U2AF1) are associated with various cancers including myelodysplastic syndrome (MDS). Mutant U2AF1 promotes malignant transformation by inhibiting autophagy, partly as a result of alterations in the 3' tail ofATG7. This results in altered mitochondrial function, increased reactive oxygen species production, and genomic instability.
authors.affiliation: Department of Medicine, Columbia University Medical Center, Columbia University , New York, USA.
authors.forename: Abdullah M
authors.initials: AM
authors.lastname: Ali
authors.affiliation: Department of Medicine, Columbia University Medical Center, Columbia University, New York, USA; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, Columbia University, New York, USA.
authors.forename: Azra
authors.initials: A
authors.lastname: Raza
keywords: 3′UTR; ATG7; U2AF1; autophagy; cancer; mechanism; myelodysplastic syndrome; splicing