title: Modular Polymer Biosensors by Solvent Immersion Imprint Lithography.
abstract: We recently demonstrated Solvent Immersion Imprint Lithography (SIIL), a rapid benchtop microsystem prototyping technique, including polymer functionalization, imprinting and bonding. Here, we focus on the realization of planar polymer sensors using SIIL through simple solvent immersion without imprinting. We describe SIIL's impregnation characteristics, including an inherent mechanism that not only achieves practical doping concentrations, but their unexpected 2-fold enhancement compared to the immersion solution. Subsequently, we developed and characterized optical sensors for detecting molecular O2. To this end, a substantially high dynamic range is reported, including its control through the immersion duration, a manifestation of SIIL's modularity. Overall, SIIL exhibits the potential of improving the operating characteristics of polymer sensors, while significantly accelerating their prototyping, as it requires a few seconds of processing and no need for substrates or dedicated instrumentation. These are critical for O2sensing as probed by way of example here, as well as any polymer permeable reactant.
authors.affiliation: Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, WA, 99352, USA.
authors.forename: J S
authors.initials: JS
authors.lastname: Moore
authors.affiliation: Physical Sciences Division, Pacific Northwest National Laboratory, PO Box 999, Richland, WA, 99352, USA.
authors.forename: S S
authors.initials: SS
authors.lastname: Xantheas
authors.affiliation: Physical Sciences Division, Pacific Northwest National Laboratory, PO Box 999, Richland, WA, 99352, USA.
authors.forename: J W
authors.initials: JW
authors.lastname: Grate
authors.affiliation: Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, WA, 99352, USA.
authors.forename: T W
authors.initials: TW
authors.lastname: Wietsma
authors.affiliation: Laboratory of Fluorescence Dynamics, Biomedical Engineering Department, University of California, Irvine, CA 92697, USA.
authors.forename: E
authors.initials: E
authors.lastname: Gratton
authors.affiliation: Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, WA, 99352, USA.; Department of Physics, University of Idaho, Moscow, ID, 83844, USA.
authors.forename: A E
authors.initials: AE
authors.lastname: Vasdekis