title: Analysis of a genotype G3P[9] rotavirus a strain that shows evidence of multiple reassortment events between animal and human rotaviruses.
abstract: The species A rotaviruses (RVA) are important gastroenteric pathogens that infect humans and animals. RVA genotype G3P[9] has been described in human-animal reassortment events, and the complexity of its hosts motivates the genetic investigation of this strain. Therefore, the aim of this study is to analyse a G3P[9] sample that was detected in a child with acute gastroenteritis. The 1A3739 sample featured the constellation G3P[9]-I18-R3-C3-Mx-A19-N3-T3-E3-H6. The sequence for VP3 gene was not obtained. The phylogeny showed a closer relationship among genes VP7, VP1, NSP3, NSP4, and NSP5 with genes of animal origin, such as chiropter, alpaca, equine, and simian. In addition, the genes VP6 and NSP1 belong to the new genotypes I18 and A19, respectively. The emergence of strains such as these can interfere with the effectiveness of the RVA vaccine, and continuous monitoring is therefore important. Additional studies are needed to determine the evolutionary source and to identify a possible reservoir of RVA in nature.
authors.affiliation: Postgraduate Program in Virology, Evandro Chagas Institute, Ananindeua, Pará, Brazil.|Virology Section, Evandro Chagas Institute, Health Surveillance Secretariat, Brazilian Ministry of Health, Ananindeua, Pará, Brazil.
authors.forename: Delana A M
authors.initials: DA
authors.lastname: Bezerra
authors.affiliation: Postgraduate Program in Virology, Evandro Chagas Institute, Ananindeua, Pará, Brazil.
authors.forename: Sylvia F S
authors.initials: SF
authors.lastname: Guerra
authors.affiliation: Postgraduate Program in Virology, Evandro Chagas Institute, Ananindeua, Pará, Brazil.
authors.forename: Ana C S
authors.initials: AC
authors.lastname: Serra
authors.affiliation: Postgraduate Program in Virology, Evandro Chagas Institute, Ananindeua, Pará, Brazil.
authors.forename: Priscylla C M S
authors.initials: PC
authors.lastname: Fecury
authors.affiliation: Postgraduate Program in Virology, Evandro Chagas Institute, Ananindeua, Pará, Brazil.|Virology Section, Evandro Chagas Institute, Health Surveillance Secretariat, Brazilian Ministry of Health, Ananindeua, Pará, Brazil.
authors.forename: Renato S
authors.initials: RS
authors.lastname: Bandeira
authors.affiliation: Postgraduate Program in Virology, Evandro Chagas Institute, Ananindeua, Pará, Brazil.
authors.forename: Edvaldo T
authors.initials: ET
authors.lastname: Penha
authors.affiliation: Postgraduate Program in Virology, Evandro Chagas Institute, Ananindeua, Pará, Brazil.|Virology Section, Evandro Chagas Institute, Health Surveillance Secretariat, Brazilian Ministry of Health, Ananindeua, Pará, Brazil.
authors.forename: Patrícia S
authors.initials: PS
authors.lastname: Lobo
authors.affiliation: Postgraduate Program in Virology, Evandro Chagas Institute, Ananindeua, Pará, Brazil.|Virology Section, Evandro Chagas Institute, Health Surveillance Secretariat, Brazilian Ministry of Health, Ananindeua, Pará, Brazil.
authors.forename: Edivaldo C
authors.initials: EC
authors.lastname: Sousa
authors.affiliation: Postgraduate Program in Virology, Evandro Chagas Institute, Ananindeua, Pará, Brazil.
authors.forename: Alexandre C
authors.initials: AC
authors.lastname: Linhares
authors.affiliation: Postgraduate Program in Virology, Evandro Chagas Institute, Ananindeua, Pará, Brazil.
authors.forename: Luana S
authors.initials: LS
authors.lastname: Soares
authors.affiliation: Postgraduate Program in Virology, Evandro Chagas Institute, Ananindeua, Pará, Brazil.
authors.forename: Joana D P
authors.initials: JD
authors.lastname: Mascarenhas
mesh_terms: D002675:Child, Preschool; D019143:Evolution, Molecular; D005260:Female; D005759:Gastroenteritis / Q000821:virology*; D005838:Genotype; D006801:Humans; D010802:Phylogeny; D016865:Reassortant Viruses / Q000235:genetics*; D011995:Recombination, Genetic; D012401:Rotavirus / Q000235:genetics* / Q000302:isolation & purification; D012400:Rotavirus Infections / Q000821:virology*; D017422:Sequence Analysis, DNA
keywords: G3P[9]; human rotavirus; interspecies transmission; rotavirus; sequence analysis