title: [Development of cerebral infarcts in a 17-year-old male treated with sertraline and lisdexamfetamine].
abstract: A 17-year-old male with ADHD who was treated with sertraline and lisdexamfetamine presented with transient episodes of speech impairment and right-sided hemiparesis preceded by headaches. Magnetic resonance imaging revealed three cerebral ischaemic lesions. Treatment was initiated with aspirin and discontinued with lisdexamfetamine. In the literature a causal relationship between treatment with central stimulants and the development of cerebrovascular events has not been substantiated. Vasospasm and paroxystic tachycardia may be associated with the event, but lisdexamfetamine and sertraline cannot be ruled out as risk factors.
authors.affiliation: malenemar@gmail.com.
authors.forename: Malene
authors.initials: M
authors.lastname: Martinussen
authors.forename: Nanette Mol
authors.initials: NM
authors.lastname: Debes
authors.forename: Catrine
authors.initials: C
authors.lastname: Christensen
authors.forename: Gabriele
authors.initials: G
authors.lastname: Leth
authors.forename: Anne Katrine
authors.initials: AK
authors.lastname: Pagsberg
authors.forename: Christina
authors.initials: C
authors.lastname: Kruuse
mesh_terms: D000293:Adolescent; D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy; D000697:Central Nervous System Stimulants / Q000009:adverse effects* / Q000627:therapeutic use; D002544:Cerebral Infarction / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000188:drug therapy; D003866:Depressive Disorder / Q000188:drug therapy; D038524:Diffusion Magnetic Resonance Imaging; D006801:Humans; D000069478:Lisdexamfetamine Dimesylate / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D020280:Sertraline / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D000697:Central Nervous System Stimulants; D000069478:Lisdexamfetamine Dimesylate; D017367:Selective Serotonin Reuptake Inhibitors; D020280:Sertraline