title: Branched and ionic β-Cyclodextrins multilayer assembling onto polyacrylonitrile membranes for removal and controlled release of triclosan.
abstract: The present study summarizes the formation and characterization of multilayers of polyacrylonitrile (PAN) membranes with β-cyclodextrin derivatives in order to be potentially interesting for triclosan (TR) controlled delivery with antibacterial purposes, as well as, for the removal of TR from wastewater. With this object, cationic and anionic branched β-cyclodextrins (bβCDs) were incorporated by layer-by-layer (LbL) process onto previously synthesized and hydrolyzed PAN membranes. FTIR, XPS and labelling with fluoresceinamine (FA) let to study the formation and stability of the prepared multilayered systems. TR is a widely used antibacterial and antifungal agent with proven ability to inhibit bacterial growth that, however, recently has shown a potential toxicity. The ability of obtained bβCDs/PAN multilayered membranes to retain TR in water was evaluated by two different loading procedures. The delivery kinetic profile of TR from loaded membranes was also analyzed showing the maximum release in the first 24h.
authors.affiliation: Departamento de Química Física (Laboratorio de Química Macromolecular), Universidad del País Vasco (UPV/EHU), B∘Sarriena s/n, 48940 Leioa, Vizcaya, Spain; BCMaterials, Bizkaia Science and Technology Park, Building 500-1st Floor, 48160 Derio, Spain. Electronic address: leyre.perez@ehu.es.
authors.forename: Leyre
authors.initials: L
authors.lastname: Pérez-Álvarez
authors.affiliation: Departamento de Química Física (Laboratorio de Química Macromolecular), Universidad del País Vasco (UPV/EHU), B∘Sarriena s/n, 48940 Leioa, Vizcaya, Spain.
authors.forename: Janire
authors.initials: J
authors.lastname: Matas
authors.affiliation: Departamento de Química Física (Laboratorio de Química Macromolecular), Universidad del País Vasco (UPV/EHU), B∘Sarriena s/n, 48940 Leioa, Vizcaya, Spain.
authors.forename: Flor
authors.initials: F
authors.lastname: Gómez-Galván
authors.affiliation: Departamento de Química Física (Laboratorio de Química Macromolecular), Universidad del País Vasco (UPV/EHU), B∘Sarriena s/n, 48940 Leioa, Vizcaya, Spain.
authors.forename: Leire
authors.initials: L
authors.lastname: Ruiz-Rubio
authors.affiliation: Departamento de Química Física (Laboratorio de Química Macromolecular), Universidad del País Vasco (UPV/EHU), B∘Sarriena s/n, 48940 Leioa, Vizcaya, Spain.
authors.forename: Luis M
authors.initials: LM
authors.lastname: León
authors.affiliation: Departamento de Química Física (Laboratorio de Química Macromolecular), Universidad del País Vasco (UPV/EHU), B∘Sarriena s/n, 48940 Leioa, Vizcaya, Spain.
authors.forename: Jose Luis
authors.initials: JL
authors.lastname: Vilas-Vilela
mesh_terms: D000180:Acrylic Resins; D003692:Delayed-Action Preparations; D014260:Triclosan / Q000737:chemistry*; D047392:beta-Cyclodextrins
chemical_list: D000180:Acrylic Resins; D003692:Delayed-Action Preparations; D047392:beta-Cyclodextrins; C010504:polyacrylonitrile; D014260:Triclosan
keywords: Ionic β-cyclodextrins; Layer by layer assembling; Multilayers; Polyacrylonitryle; Triclosan