title: Adipose tissue dysfunction increases fatty liver association with pre diabetes and newly diagnosed type 2 diabetes mellitus.
abstract: BACKGROUND
  To evaluate the role of adipose tissue function on the association of fatty liver (FL) with impaired fasting glucose (IFG) or newly diagnosed type 2 diabetes mellitus (nT2D).
  
  
  METHODS
  In 1264 subjects, computed tomography was used to evaluate FL and elevated visceral adipose tissue (VAT). Fasting plasma glucose, <5.6, 5.6-6.9 and ≥7 mmol/l, were used to defined normoglycemic (NG), IFG or nT2D, respectively. Elevated free fatty acids, low serum adiponectin levels and adipose tissue insulin resistance (Adipo-IR), were used as markers of adipose tissue dysfunction.
  
  
  RESULTS
  Compared to NG subjects, those with IFG or nT2D had higher prevalence of FL and elevated VAT. FL was found to be independently associated with IFG and nT2D. Adipo-IR increased the association between FL and IFG [OR: 2.46 (95% I.C.: 1.73-3.49) to 5.42 (3.11-9.41)], whereas low adiponectin levels had a higher effect on the FL and nT2D association [OR: 4.26 (2.18-8.34) to 8.53 (2.96-24.55)].
  
  
  CONCLUSIONS
  Fatty liver was independently associated with IFG and nT2D. Our results indicate for the first time, that adipose tissue dysfunction increases these associations.
authors.affiliation: Endocrinology Department, National Institute of Cardiology "Ignacio Chávez", Juan Badiano No. 1, Col Sección XVI, Tlalpan, 14080 Mexico, Mexico.
authors.forename: Esteban
authors.initials: E
authors.lastname: Jorge-Galarza
authors.affiliation: Endocrinology Department, National Institute of Cardiology "Ignacio Chávez", Juan Badiano No. 1, Col Sección XVI, Tlalpan, 14080 Mexico, Mexico.
authors.forename: Aida
authors.initials: A
authors.lastname: Medina-Urrutia
authors.affiliation: Endocrinology Department, National Institute of Cardiology "Ignacio Chávez", Juan Badiano No. 1, Col Sección XVI, Tlalpan, 14080 Mexico, Mexico.
authors.forename: Rosalinda
authors.initials: R
authors.lastname: Posadas-Sánchez
authors.affiliation: Endocrinology Department, National Institute of Cardiology "Ignacio Chávez", Juan Badiano No. 1, Col Sección XVI, Tlalpan, 14080 Mexico, Mexico.
authors.forename: Carlos
authors.initials: C
authors.lastname: Posadas-Romero
authors.affiliation: Endocrinology Department, National Institute of Cardiology "Ignacio Chávez", Juan Badiano No. 1, Col Sección XVI, Tlalpan, 14080 Mexico, Mexico.
authors.forename: Guillermo
authors.initials: G
authors.lastname: Cardoso-Saldaña
authors.affiliation: Molecular Biology Department, National Institute of Cardiology "Ignacio Chávez", Mexico, Mexico.
authors.forename: Gilberto
authors.initials: G
authors.lastname: Vargas-Alarcón
authors.affiliation: Endocrinology Department, National Institute of Cardiology "Ignacio Chávez", Juan Badiano No. 1, Col Sección XVI, Tlalpan, 14080 Mexico, Mexico.
authors.forename: Nacú
authors.initials: N
authors.lastname: Caracas-Portilla
authors.affiliation: Endocrinology Department, National Institute of Cardiology "Ignacio Chávez", Juan Badiano No. 1, Col Sección XVI, Tlalpan, 14080 Mexico, Mexico.
authors.forename: Carmen
authors.initials: C
authors.lastname: González-Salazar
authors.affiliation: Endocrinology Department, National Institute of Cardiology "Ignacio Chávez", Juan Badiano No. 1, Col Sección XVI, Tlalpan, 14080 Mexico, Mexico.
authors.forename: Margarita
authors.initials: M
authors.lastname: Torres-Tamayo
authors.affiliation: Endocrinology Department, National Institute of Cardiology "Ignacio Chávez", Juan Badiano No. 1, Col Sección XVI, Tlalpan, 14080 Mexico, Mexico.
authors.forename: Juan Gabriel
authors.initials: JG
authors.lastname: Juárez-Rojas
keywords: Impaired fasting glucose; Insulin resistance; Liver fat; Type 2 diabetes mellitus; Visceral fat