title: Extract of Ferula foetida regel reverses gentamicin-induced nephrotoxicity in rats.
abstract: Natural products and dietary components have earlier been proven as potential chemoprotective agents, and continuous efforts are in progress to search for such new products. Gentamicin, an aminoglycoside antibiotic, is widely used for treating the infections caused by many gram negative bacteria. However, besides other unwanted effects, the drug causes tubular cell necrosis in the proximal convoluted tubules of nephrons. Unavailability of any remedial measures in the modern medicine for such ailments therefore makes it imperative to screen for natural products that are nephroprotective against such renal impairment. Here in the undertaken study, we have tested nephroprotective effects of Hing (Ferula foetida) extracts on gentamicin-treated rats. As expected, subcutaneous administration of rats with Gentamicin (100 mg/kg) showed significant increase in blood urea nitrogen (BUN), serum creatinine and thiobarbituric acid reacting substances (TBARS), as an indication of renal disorder. However, co-administration of methanol soluble and insoluble fractions ofFerula foetida(Hing), to the Gentamicin-treated rats almost showed a complete reversal of the above effects, indicating nephroprotective properties of the herbal drug. This may be an important addition to the list of studies where natural products have been discovered to be chemoprotective.
authors.affiliation: Department of Ilmul Advia (Pharmacology), Faculty of Medicine (U), Jamia Hamdard, New Delhi, India.
authors.forename: Rasikh
authors.initials: R
authors.lastname: Javaid
authors.affiliation: Department of Ilmul Advia (Pharmacology), Faculty of Medicine (U), Jamia Hamdard, New Delhi, India.
authors.forename: Mohd
authors.initials: M
authors.lastname: Aslam
authors.affiliation: Department of Moalijat, Faculty of Medicine (U), Jamia Hamdard, New Delhi, India.
authors.forename: Raheela
authors.initials: R
authors.lastname: Javaid
authors.affiliation: Department of Ilmul Advia (Pharmacology), Faculty of Medicine (U), Jamia Hamdard, New Delhi, India.
authors.forename: Qudsia
authors.initials: Q
authors.lastname: Nizami
authors.affiliation: Department of Chemistry, Faculty of Science, Hamdard University, New Delhi, India.
authors.forename: Kalim
authors.initials: K
authors.lastname: Javed
authors.affiliation: Research Officer (Scientist II), Central Council of Research in Unani Medicine, Janakpuri, New Delhi, India.
authors.forename: M U
authors.initials: MU
authors.lastname: Azhar
keywords: Ferula foetida; blood urea nitrogen; gentamicin; nephrotoxicity; serum creatinine