title: Safflower (Catharmus tinctorius L.) oil supplementation in overnourished rats during early neonatal development: effects on heart and liver function in the adult.
abstract: Carthamus tinctorius L. (common name: safflower) is an herb whose extracted oil (safflower oil) has been employed in both alternative and conventional medicine in the treatment of disease. Overnutrition during early postnatal life can increase the lifetime risk of obesity and metabolic syndrome. Here we investigate the effect of safflower oil supplementation given during a critical early developmental stage on the eventual occurrence of metabolic disease in overnourished rats. Groups of overnourished or adequately nourished rats were randomly assigned into 2 additional groups for supplementation with either safflower oil (SF) or vehicle for 7 to 30 days. Murinometric data and weights were examined. Serum was collected for measurement of glucose, cholesterol, high-density lipoprotein cholesterol, and triglycerides. Heart and liver oxidative status were also measured. Overnutrition for 7-30 days induced a significant increase in body weight and in values for abdominal circumference, thoracic circumference, body length, and body mass index. SF supplementation did not attenuate the effect of overnutrition on any of these parameters. In addition, overnutrition increased levels of glucose, triglycerides, and very low-density lipid compared with normal controls, but SF supplementation had no effect on these parameters. Measures of oxidative status in heart or liver were not influenced by overnutrition. However, oxidative measures were altered by SF supplementation in both of these organs. The present study reveals that nutritional manipulation during early development induces detrimental effects on metabolism in the adult that are not ameliorated by supplemental SF.
authors.affiliation: a Department of Nutrition/Centro de Ciencias da Saude (CCS). Federal University of Pernambuco, Campus of Recife, Recife, PE 55608-680, Brazil.
authors.forename: Laís Ribeiro
authors.initials: LR
authors.lastname: Costa
authors.affiliation: a Department of Nutrition/Centro de Ciencias da Saude (CCS). Federal University of Pernambuco, Campus of Recife, Recife, PE 55608-680, Brazil.
authors.forename: Patrícia Cavalcanti
authors.initials: PC
authors.lastname: Macêdo
authors.affiliation: a Department of Nutrition/Centro de Ciencias da Saude (CCS). Federal University of Pernambuco, Campus of Recife, Recife, PE 55608-680, Brazil.
authors.forename: Janatar Stella Vasconcelos
authors.initials: JS
authors.lastname: de Melo
authors.affiliation: b Laboratory of Biochemistry and Exercise Biochemistry, Federal University of Pernambuco, Campus of Vitoria de Santo Antao, Vitoria de Santo Antao, PE, Brazil.
authors.forename: Cristiane Moura
authors.initials: CM
authors.lastname: Freitas
authors.affiliation: b Laboratory of Biochemistry and Exercise Biochemistry, Federal University of Pernambuco, Campus of Vitoria de Santo Antao, Vitoria de Santo Antao, PE, Brazil.
authors.forename: Aiany Simoes
authors.initials: AS
authors.lastname: Alves
authors.affiliation: c Department of Physiology and Pharmacology/Centro de Ciências Biológicas (CCB), Federal University of Pernambuco, Campus of Recife, Recife, PE, Brazil.
authors.forename: Humberto de Moura
authors.initials: HM
authors.lastname: Barbosa
authors.affiliation: c Department of Physiology and Pharmacology/Centro de Ciências Biológicas (CCB), Federal University of Pernambuco, Campus of Recife, Recife, PE, Brazil.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Lira
authors.affiliation: b Laboratory of Biochemistry and Exercise Biochemistry, Federal University of Pernambuco, Campus of Vitoria de Santo Antao, Vitoria de Santo Antao, PE, Brazil.
authors.forename: Mariana Pinheiro
authors.initials: MP
authors.lastname: Fernandes
authors.affiliation: a Department of Nutrition/Centro de Ciencias da Saude (CCS). Federal University of Pernambuco, Campus of Recife, Recife, PE 55608-680, Brazil.
authors.forename: Manuella
authors.initials: M
authors.lastname: Batista-de-Oliveira-Hornsby
authors.affiliation: b Laboratory of Biochemistry and Exercise Biochemistry, Federal University of Pernambuco, Campus of Vitoria de Santo Antao, Vitoria de Santo Antao, PE, Brazil.
authors.forename: Claudia
authors.initials: C
authors.lastname: Lagranha
mesh_terms: D000818:Animals; D031187:Carthamus tinctorius / Q000737:chemistry*; D019587:Dietary Supplements / Q000009:adverse effects; D043371:Fatty Acids, Omega-6 / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006943:Hyperglycemia / Q000209:etiology; D006949:Hyperlipidemias / Q000209:etiology; D007774:Lactation; D008099:Liver / Q000378:metabolism*; D008297:Male; D039382:Maternal Nutritional Physiological Phenomena; D009206:Myocardium / Q000378:metabolism*; D009765:Obesity / Q000209:etiology / Q000517:prevention & control; D044343:Overnutrition / Q000097:blood / Q000178:diet therapy* / Q000378:metabolism / Q000503:physiopathology; D018384:Oxidative Stress; D028321:Plant Preparations / Q000009:adverse effects / Q000627:therapeutic use; D011247:Pregnancy; D011897:Random Allocation; D017208:Rats, Wistar; D012450:Safflower Oil / Q000009:adverse effects / Q000627:therapeutic use*; D014886:Weaning; D015430:Weight Gain
chemical_list: D043371:Fatty Acids, Omega-6; D028321:Plant Preparations; D012450:Safflower Oil
keywords: Carthamus tinctorius L. oil; heart; liver; overnourishment; oxidative status; statut oxydatif, cœur, foie; suralimentation, huile de carthamus tinctorius