title: Hormones in pain modulation and their clinical implications for pain control: a critical review.
abstract: Recently, more and more studies have found that pain generation, transmission and modulation are under hormonal regulation. Indeed, hormonal dysregulation is a common component of chronic pain syndromes. Studies have attempted to determine whether the relationship between the pain and its perception and hormones is a causative relationship and how these processes interrelate. This review summarizes and analyzes the current experimental data and provides an overview of the studies addressing these questions. The relationship between pain perception and endocrine effects suggests that hormones can be used as important biomarkers of chronic pain syndromes and/or be developed into therapeutic agents in the fight against pain.
authors.affiliation: Department of Pain Management, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 1630 Dongfang Road, Shanghai, 200127, China.
authors.forename: Xueyin
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Pain Management, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 1630 Dongfang Road, Shanghai, 200127, China.
authors.forename: Jinyuan
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Pain Management, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 1630 Dongfang Road, Shanghai, 200127, China. xiangrui68@163.com.
authors.forename: Xiangrui
authors.initials: X
authors.lastname: Wang
mesh_terms: D000700:Analgesics / Q000627:therapeutic use*; D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D006728:Hormones / Q000378:metabolism*; D006801:Humans; D010146:Pain / Q000378:metabolism* / Q000503:physiopathology / Q000517:prevention & control* / Q000523:psychology; D058748:Pain Perception / Q000187:drug effects*; D017288:Pain Threshold / Q000187:drug effects*; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D000700:Analgesics; D015415:Biomarkers; D006728:Hormones