title: A study of enhanced ion formation from metal-semiconductor complexes in atmospheric pressure laser desorption/ionization mass spectrometry.
abstract: The study of the key parameters impacted surface-assisted laser desorption/ionization-mass spectrometry is of broad interest. In previous studies, it has been shown that surface-assisted laser desorption/ionization-mass spectrometry is a complex process depending on multiple factors. In the presented study, we showed that neither porosity, light absorbance nor surface hydrophobicity alone influence the enhancement phenomena observed from the hybrid metal-semiconductor complexes versus individual targets, but small changes in the analyte attaching to the target significantly affect laser desorption ionization-efficiency. By means of Raman spectroscopy and scanning electron microscopy, it was revealed that the formation of an amorphous analyte layer after drying on a solid substrate was essential for the enhanced laser desorption ionization-signal observed from the hybrid metal-semiconductor targets, and the crystallization properties of the analyte appeared as a function of the substrate. Obtained results were used for the screening of regular and lactose-free milk samples through the hybrid metal-semiconductor target. Copyright © 2016 John Wiley & Sons, Ltd.
authors.affiliation: INM-Leibniz Institute for New Materials, Campus D2 2, Saarbrücken, 66123, Germany.
authors.forename: Yuliya E
authors.initials: YE
authors.lastname: Silina
authors.affiliation: INM-Leibniz Institute for New Materials, Campus D2 2, Saarbrücken, 66123, Germany.
authors.forename: Petra
authors.initials: P
authors.lastname: Herbeck-Engel
authors.affiliation: INM-Leibniz Institute for New Materials, Campus D2 2, Saarbrücken, 66123, Germany.
authors.forename: Marcus
authors.initials: M
authors.lastname: Koch
keywords: SALDI-MS; analyte attachment; hybrid metal-semiconductor target; milk screening; polymorphism