title: Molecular, Spatial, and Field Epidemiology Suggesting TB Transmission in Community, Not Hospital, Gaborone, Botswana.
abstract: During 2012-2015, 10 of 24 patients infected with matching genotypes of Mycobacterium tuberculosis received care at the same hospital in Gaborone, Botswana. Nosocomial transmission was initially suspected, but we discovered plausible sites of community transmission for 20 (95%) of 21 interviewed patients. Active case-finding at these sites could halt ongoing transmission.
authors.forename: Diya
authors.initials: D
authors.lastname: Surie
authors.forename: Othusitse
authors.initials: O
authors.lastname: Fane
authors.forename: Alyssa
authors.initials: A
authors.lastname: Finlay
authors.forename: Matsiri
authors.initials: M
authors.lastname: Ogopotse
authors.forename: James L
authors.initials: JL
authors.lastname: Tobias
authors.forename: Eleanor S
authors.initials: ES
authors.lastname: Click
authors.forename: Chawangwa
authors.initials: C
authors.lastname: Modongo
authors.forename: Nicola M
authors.initials: NM
authors.lastname: Zetola
authors.forename: Patrick K
authors.initials: PK
authors.lastname: Moonan
authors.forename: John E
authors.initials: JE
authors.lastname: Oeltmann
mesh_terms: D000293:Adolescent; D000328:Adult; D001902:Botswana / Q000453:epidemiology; D016000:Cluster Analysis; D017714:Community-Acquired Infections / Q000453:epidemiology / Q000382:microbiology* / Q000635:transmission*; D004196:Disease Outbreaks; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D017720:Molecular Epidemiology; D009169:Mycobacterium tuberculosis / Q000235:genetics* / Q000302:isolation & purification; D014376:Tuberculosis / Q000453:epidemiology / Q000382:microbiology* / Q000635:transmission*; D055815:Young Adult
keywords: Africa; Botswana; GIS; Gaborone; Mycobacterium tuberculosis; TB; bacteria; cluster; community transmission; epidemiology; genotyping; geographic information system; mapping; nosocomial transmission; outbreak; transmission; transmission dynamics; tuberculosis; tuberculosis and other mycobacteria