title: Furostanol Saponins from the Bulbs of Welsh Onion, Allium fistulosum L.
abstract: An extensive phytochemical analysis of the polar extracts from bulbs of Welsh onionAllium fistulosumL. led to the isolation of nine saponins, four of them, named fistulosaponins G (1a/1b), H (2), I (3a/3b), and J (4), have never been reported previously. Fistulosaponins G and I were isolated as a couple of isomers in equilibrium. On the basis of 2D NMR and mass spectrometry data, the structure of the novel compounds were elucidated as (25R)-26-[(β-D-glucopyranosyl)oxy]-3β,22β-dihydroxyfurost-5-en-1β-yl O-α-L-rhamnopyranosyl-(1 → 4)-O-α-L-rhamnopyranosyl-(1 → 4)-β-D-glucopyranoside (1a) with its 22αepimer (1b), (25R)-26-[(β-D-glucopyranosyl)oxy]-3β-hydroxyfurost-5,20-dien-1β-yl O-α-L-rhamnopyranosyl-(1 → 4)-O-α-L-rhamnopyranosyl-(1 → 4)-β-D-glucopyranoside (2), (25R)-26-[(β-D-glucopyranosyl)oxy]-3β,22β-dihydroxyfurost-5-en-1β-yl O-α-L-rhamnopyranosyl-(1 → 4)-β-D-glucopyranoside (3a) with its 22αepimer (3b), and (25R)-26-[(β-D-glucopyranosyl)oxy]-3β-hydroxyfurost-5,20-dien-1β-yl O-α-L-rhamnopyranosyl-(1 → 4)-β-D-glucopyranoside (4). This is the first report of furostanol saponins inA. fistulosumbulbs. In addition, data on the antibacterial tests of the isolated saponins againstEscherichia coliandEnterococcus faecalisare reported.
authors.affiliation: Department of Pharmacognosy, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Behzad
authors.initials: B
authors.lastname: Zolfaghari
authors.affiliation: Department of Pharmacognosy, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Zeinab
authors.initials: Z
authors.lastname: Yazdiniapour
authors.affiliation: Department of Pharmacognosy, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Masoud
authors.initials: M
authors.lastname: Sadeghi
authors.affiliation: Department of Agricultural Sciences, University of Naples Federico II, Portici, Naples, Italy.
authors.forename: Raffaele
authors.initials: R
authors.lastname: Troiano
authors.affiliation: Department of Agricultural Sciences, University of Naples Federico II, Portici, Naples, Italy.
authors.forename: Virginia
authors.initials: V
authors.lastname: Lanzotti
mesh_terms: D000490:Allium / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D013293:Enterococcus faecalis / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000737:chemistry; D012503:Saponins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D010936:Plant Extracts; D012503:Saponins