title: Single injection protocol for coronary and lower extremity CT angiographies in patients suspected for peripheral arterial disease.
abstract: To evaluate the feasibility of a single injection protocol for coronary CT angiography (CTA) and lower extremity CTA in patients suspected for peripheral arterial disease (PAD).This prospective observational study included a total of 103 patients who showed an ankle brachial index ≤0.9 and underwent the single injection protocol for coronary and lower extremity CTA. All CTAs used iodinated contrast (weight × 0.06 mL/s × 20 seconds). A prospective Electrocardiogram (ECG)-gated coronary CTA was performed, followed by helical lower extremity CTA beginning 9 seconds after coronary CTA. Using catheter angiography as reference standard, diagnostic ability of CTA was evaluated.The mean total volume of iodinated contrast used was 70 ± 14 mL. Contrast opacification in the superficial femoral artery was adequate (408 ± 97  Hounsfield Units [HU]) and PAD was detected in 72.8% (75/103). The estimated radiation doses for lower extremity and coronary CTA were 3.6 ± 1.2 and 5.5 ± 4.5 mSv. A significant coronary stenosis was detected in 47 patients (45.6%). Coronary CT image quality was recorded as excellent in 86.4%, acceptable in 11.7%, and unacceptable for 1.9%. Contrast opacification within the superficial femoral artery was adequate in all cases while 27.2% needed an additional scan below the calf to capture the contrast bolus arrival in the smaller lower extremity vessels. Segment based sensitivity, specificity, positive, and negative predictive values were 57.9%, 97.9%, 73.8%, and 95.9% for the coronary CTA, and 63.4%, 91.5%, 76.3%, and 85.3% for peripheral CTA.A single injection protocol for coronary CTA and lower extremity CTA is feasible with a relatively small volume of iodinated contrast.
authors.affiliation: Department of Radiology, Applied Imaging Science Laboratory, Brigham and Women's Hospital & Harvard Medical School, Boston, Massachusetts Department of Cardiology Department of Radiology, Takase Clinic, Takasaki Department of Radiology, UT Southwestern Medical Center, Dallas, Texas Department of Radiology, The Ottawa Hospital and Ottawa University, Ottawa, Ontario, Canada Department of Radiology, Juntendo University, Tokyo, Japan.
authors.forename: Ashish
authors.initials: A
authors.lastname: Khandelwal
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kondo
authors.forename: Makoto
authors.initials: M
authors.lastname: Amanuma
authors.forename: Akitsugu
authors.initials: A
authors.lastname: Oida
authors.forename: Tomonari
authors.initials: T
authors.lastname: Sano
authors.forename: Saboo S
authors.initials: SS
authors.lastname: Sachin
authors.forename: Shinichi
authors.initials: S
authors.lastname: Takase
authors.forename: Frank J
authors.initials: FJ
authors.lastname: Rybicki
authors.forename: Kanako K
authors.initials: KK
authors.lastname: Kumamaru
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000072226:Computed Tomography Angiography / Q000379:methods*; D003287:Contrast Media / Q000627:therapeutic use; D003324:Coronary Artery Disease / Q000175:diagnosis*; D003331:Coronary Vessels / Q000000981:diagnostic imaging / Q000473:pathology; D004562:Electrocardiography / Q000379:methods; D005240:Feasibility Studies; D005260:Female; D005263:Femoral Artery / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D035002:Lower Extremity / Q000098:blood supply; D008297:Male; D058729:Peripheral Arterial Disease / Q000175:diagnosis*; D011829:Radiation Dosage; D011857:Radiographic Image Interpretation, Computer-Assisted; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media