title: Role of Wnt5a in the Pathogenesis of Inflammatory Diseases.
abstract: Wnt5a initiates pro-inflammatory responses through activation of non-canonical Wnt signaling pathway. Pro-inflammatory functions of Wnt5a trigger pro-inflammatory signaling cascades and increase secretion of pro-inflammatory cytokines and chemokines. Wnt5a as a potent signaling molecule is strongly implicated in a number of diseases including cancer, diabetes, metabolic disorders, and of special interest in this review, inflammatory diseases. This review summarizes the role of Wnt5a in the pathogenesis of inflammatory diseases including atherosclerosis, rheumatoid arthritis, psoriasis vulgaris and sepsis, promoting greater understanding, and clinical management of these diseases. J. Cell. Physiol. 232: 1611-1616, 2017. © 2016 Wiley Periodicals, Inc.
authors.affiliation: Department of Medical Biochemistry, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Mehran
authors.initials: M
authors.lastname: Pashirzad
authors.affiliation: Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Mojtaba
authors.initials: M
authors.lastname: Shafiee
authors.affiliation: Department of Medical Biochemistry, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Farzad
authors.initials: F
authors.lastname: Rahmani
authors.affiliation: Department of Biology, Tehran North Branch, Islamic Azad University, Tehran, Iran.
authors.forename: Reihane
authors.initials: R
authors.lastname: Behnam-Rassouli
authors.affiliation: Department of Medical Biochemistry, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Hoseinkhani
authors.affiliation: Department of Biochemistry and Molecular Biology, St. Louis University School of Medicine, Saint Louis, Missouri.
authors.forename: Mikhail
authors.initials: M
authors.lastname: Ryzhikov
authors.affiliation: Department of Medical Biochemistry, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Moradi Binabaj
authors.affiliation: Department of Medical Biochemistry, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Parizadeh
authors.affiliation: Molecular Medicine Group, Department of Modern Sciences and Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.|Departments of Medical Oncology and Neurology, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: Amir
authors.initials: A
authors.lastname: Avan
authors.affiliation: Department of Medical Biochemistry, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.|Department of Biochemistry and Molecular Biology, St. Louis University School of Medicine, Saint Louis, Missouri.|Microanatomy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.|Metabolic Syndrome Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Seyed Mahdi
authors.initials: SM
authors.lastname: Hassanian
mesh_terms: D006801:Humans; D007249:Inflammation / Q000378:metabolism* / Q000473:pathology*; D008954:Models, Biological; D051153:Wnt Proteins / Q000378:metabolism*; D060449:Wnt Signaling Pathway
chemical_list: D051153:Wnt Proteins