title: Immune Cell-Supplemented Human Skin Model for Studying Fungal Infections.
abstract: Human skin is a niche for various fungal species which either colonize the surface of this tissue as commensals or, primarily under conditions of immunosuppression, invade the skin and cause infection. Here we present a method for generation of a human in vitro skin model supplemented with immune cells of choice. This model represents a complex yet amenable tool to study molecular mechanisms of host-fungi interactions at human skin.
authors.affiliation: Fraunhofer Institute for Interfacial Engineering and Biotechnology, Nobelstrasse 12, Stuttgart, 70569, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Kühbacher
authors.affiliation: Fraunhofer Institute for Interfacial Engineering and Biotechnology, Nobelstrasse 12, Stuttgart, 70569, Germany.|Institute of Interfacial Process Engineering and Plasma Technology, University of Stuttgart, Nobelstrasse. 12, Stuttgart, 70569, Germany.
authors.forename: Kai
authors.initials: K
authors.lastname: Sohn
authors.affiliation: Fraunhofer Institute for Interfacial Engineering and Biotechnology, Nobelstrasse 12, Stuttgart, 70569, Germany.
authors.forename: Anke
authors.initials: A
authors.lastname: Burger-Kentischer
authors.affiliation: Fraunhofer Institut für Grenzflächenund Bioverfahrenstechnik, Nobelstr. 12, Stuttgart, 70569, Germany. Steffen.Rupp@igb.fraunhofer.de.|Institut für Grenzflächenverfahrenstechnik undPlasmatechnologie, Universität Stuttgart, Nobelstr. 12, Stuttgart, 70569, Germany. Steffen.Rupp@igb.fraunhofer.de.
authors.forename: Steffen
authors.initials: S
authors.lastname: Rupp
mesh_terms: D000818:Animals; D002176:Candida albicans / Q000502:physiology; D002177:Candidiasis / Q000276:immunology / Q000382:microbiology*; D018929:Cell Culture Techniques; D054884:Host-Pathogen Interactions; D006801:Humans; D019169:Jurkat Cells; D008954:Models, Biological; D012867:Skin / Q000276:immunology / Q000382:microbiology* / Q000473:pathology
keywords: 3D skin model; Host–fungi interaction; Immune reaction to fungi; Infection model