title: Tagging polymorphisms of methyl-CpG binding domain 4 and gastric cardiac adenocarcinoma risk in a Chinese population.
abstract: Potential effects of genetic factors on carcinogenesis of gastric cardiac adenocarcinoma (GCA) may exist. The present experiment specifically evaluated the genetic influence of single nucleotide in methyl-CpG binding domain 4 (MBD4) on GCA tumorigenesis. A case-control experiment based on hospital recruited 330 GCA patients and 608 non-cancer patients was carried out. We employed ligation detection reaction method to detect the genotypes. The results revealed that MBD4 rs3138373, rs2005618, and rs3138355 mutations had no significant association with the risk of GCA. However, a lower risk of GCA presented in male patients who carried the MBD4 rs3138355 G>A polymorphic loci by the stratified analyses. In general, The MBD4 gene polymorphism could not influence GCA hereditary predisposition. Nevertheless, whether the finding learned from our experiment could apply to other ethnic groups will remain vague until future multicenter studies further test and verify our conclusions.
authors.affiliation: Department of Cardiovascular Surgery of the First Affiliated Hospital, Institute for Cardiovascular Science of Soochow University, Soochow.
authors.forename: Xu
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Cardiovascular Surgery of the First Affiliated Hospital, Institute for Cardiovascular Science of Soochow University, Soochow.
authors.forename: Changqing
authors.initials: C
authors.lastname: Dong
authors.affiliation: Department of Cardiothoracic Surgery of Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Yin
authors.affiliation: Department of Cardiothoracic Surgery of Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu, China.
authors.forename: Weifeng
authors.initials: W
authors.lastname: Tang
authors.affiliation: Department of Cardiovascular Surgery of the First Affiliated Hospital, Institute for Cardiovascular Science of Soochow University, Soochow.
authors.forename: Zhenya
authors.initials: Z
authors.lastname: Shen
mesh_terms: D000230:Adenocarcinoma / Q000208:ethnology / Q000235:genetics*; D000368:Aged; D044466:Asian People / Q000235:genetics*; D002299:Cardia; D016022:Case-Control Studies; D002681:China; D004706:Endodeoxyribonucleases / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000208:ethnology; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D012737:Sex Factors; D013274:Stomach Neoplasms / Q000208:ethnology / Q000235:genetics*
chemical_list: D004706:Endodeoxyribonucleases; C118712:MBD4 protein, human
keywords: MBD4; adenocarcinoma; gastric cardiac; molecular epidemiology; polymorphisms