title: Design of chalcogen-containing norepinephrines: efficient GPx mimics and strong cytotoxic agents against HeLa cells.
abstract: Numerous chronic diseases exhibit multifactorial etiologies, so focusing on a single therapeutic target is usually an inadequate treatment; instead, multi-target drugs are preferred. Herein, a panel of phenolic thioureas and selenoureas were designed as new prototypes against multifactorial diseases concerning antioxidation and cytotoxicity, as a pro-oxidant environment is usually found in such diseases.
  
  
  
  Selenoureas were excellent antiradical agents and biomimetic catalysts of glutathione peroxidase for the scavenging of H2O2. They were also potent and selective cytotoxic agents against cancer cells, in particular HeLa (IC502.77-6.13 μM), apoptosis being involved. Selenoureas also reduced oxidative stress in HeLa cells (IC50= 3.76 μM).
  
  
  
  Phenolic selenoureas are promising lead structures for the development of drugs targeting multifactorial diseases like cancer.
authors.affiliation: Departamento de Química Orgánica, Facultad de Química, Universidad de Sevilla, Apartado 1203, 41071, Seville, Spain.
authors.forename: Azucena
authors.initials: A
authors.lastname: Marset
authors.affiliation: Departamento de Química Orgánica, Facultad de Química, Universidad de Sevilla, Apartado 1203, 41071, Seville, Spain.
authors.forename: Paloma
authors.initials: P
authors.lastname: Begines
authors.affiliation: Departamento de Química Orgánica, Facultad de Química, Universidad de Sevilla, Apartado 1203, 41071, Seville, Spain.
authors.forename: Óscar
authors.initials: Ó
authors.lastname: López
authors.affiliation: Departamento de Química Orgánica, Facultad de Química, Universidad de Sevilla, Apartado 1203, 41071, Seville, Spain.
authors.forename: Inés
authors.initials: I
authors.lastname: Maya
authors.affiliation: Functinal Validation & Preclinical Research (FVPR), CIBBIM-Nanomedicine, Hospital Universitari Vall d'Hebroón & Vall d'Hebrón Institut de Recerca, Universitat Autònoma de Barcelona, 08035 Barcelona, Spain.|Centro de Investigación Biomédica en Red - Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), 28029 Madrid, Spain.
authors.forename: Natalia
authors.initials: N
authors.lastname: García-Aranda
authors.affiliation: Functinal Validation & Preclinical Research (FVPR), CIBBIM-Nanomedicine, Hospital Universitari Vall d'Hebroón & Vall d'Hebrón Institut de Recerca, Universitat Autònoma de Barcelona, 08035 Barcelona, Spain.|Centro de Investigación Biomédica en Red - Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), 28029 Madrid, Spain.
authors.forename: Simó
authors.initials: S
authors.lastname: Schwartz
authors.affiliation: Functinal Validation & Preclinical Research (FVPR), CIBBIM-Nanomedicine, Hospital Universitari Vall d'Hebroón & Vall d'Hebrón Institut de Recerca, Universitat Autònoma de Barcelona, 08035 Barcelona, Spain.|Centro de Investigación Biomédica en Red - Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), 28029 Madrid, Spain.
authors.forename: Ibane
authors.initials: I
authors.lastname: Abasolo
authors.affiliation: Departamento de Química Orgánica, Facultad de Química, Universidad de Sevilla, Apartado 1203, 41071, Seville, Spain.
authors.forename: José G
authors.initials: JG
authors.lastname: Fernández-Bolaños
mesh_terms: D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D018011:Chalcogens / Q000737:chemistry / Q000494:pharmacology*; D003603:Cytotoxins / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D015195:Drug Design; D006367:HeLa Cells; D006801:Humans; D009638:Norepinephrine / Q000737:chemistry / Q000494:pharmacology*; D016566:Organoselenium Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D018384:Oxidative Stress / Q000187:drug effects
chemical_list: D000975:Antioxidants; D018011:Chalcogens; D003603:Cytotoxins; D016566:Organoselenium Compounds; D009638:Norepinephrine
keywords: GPx mimics; antioxidants; catechol; cytotoxic agents; selenoureas