title: Readily Accessible and Highly Efficient Ferrocene-Based Amino-Phosphine-Alcohol (f-Amphol) Ligands for Iridium-Catalyzed Asymmetric Hydrogenation of Simple Ketones.
abstract: We have successfully developed a series of novel and modular ferrorence-based amino-phosphine-alcohol (f-Amphol) ligands, and applied them to iridium-catalyzed asymmetric hydrogenation of various simple ketones to afford the corresponding chiral alcohols with excellent enantioselectivities and conversions (98-99.9 % ee, >99 % conversion, turnover number up to 200 000). Control experiments and density functional theory (DFT) calculations have shown that the hydroxyl group of our f-Amphol ligands played a key role in this asymmetric hydrogenation.
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei, 430072, P.R. China.
authors.forename: Jianfei
authors.initials: J
authors.lastname: Yu
authors.affiliation: School of Chemistry and Chemical Engineering, Chongqing University, Chongqing, 400030, P.R. China.
authors.forename: Meng
authors.initials: M
authors.lastname: Duan
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei, 430072, P.R. China.
authors.forename: Weilong
authors.initials: W
authors.lastname: Wu
authors.affiliation: School of Chemistry and Chemical Engineering, Chongqing University, Chongqing, 400030, P.R. China.
authors.forename: Xiaotian
authors.initials: X
authors.lastname: Qi
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei, 430072, P.R. China.
authors.forename: Peng
authors.initials: P
authors.lastname: Xue
authors.affiliation: School of Chemistry and Chemical Engineering, Chongqing University, Chongqing, 400030, P.R. China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Lan
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei, 430072, P.R. China.
authors.forename: Xiu-Qin
authors.initials: XQ
authors.lastname: Dong
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei, 430072, P.R. China.|Department of Chemistry, South University of Science and Technology of China, Shenzhen, Guangdong, 518055, P. R. China.
authors.forename: Xumu
authors.initials: X
authors.lastname: Zhang
keywords: asymmetric catalysis; chiral alcohols; ferrocenyl; ketones; ligands