title: Involvement of serum glucocorticoid-regulated kinase 1 in reproductive success.
abstract: Reproductive processes, in particular events that concern pregnancy, are fine-tuned to produce offspring. Reproductive success is of prime importance for the survival of every species. The highly conserved and ubiquitously expressed serum glucocorticoid-regulated kinase 1 (SGK1) was first implicated in infertility as a regulator of a Na+channel. In this review, we emphasize the prominent role of SGK1 during early pregnancy: 1) balancing uterine luminal fluid secretion and reabsorption to aid blastocyst adhesion and to import nutrients and energy; 2) transducing signals from the blastocyst to the receptive endometrium; 3) inducing multiple genes that are involved in uterine receptivity and trophoblast invasion; 4) regulating cell differentiation and antioxidant defenses at the fetomaternal interface; and 5) contributing to the proliferation and survival of decidual stromal cells. Accordingly, SGK1 coordinates many cellular processes that are crucial to reproductive activities. Aberrant expression or function of SGK1 results in implantation failure and early pregnancy loss. Further investigation of the molecular mechanisms of the function of SGK1 might provide novel diagnostic tools and interventions for reproductive complications.-Lou, Y., Hu, M., Mao, L., Zheng, Y., Jin, F. Involvement of serum glucocorticoid-regulated kinase 1 in reproductive success.
authors.affiliation: Department of Reproductive Endocrinology, Women's Hospital, Zhejiang University School of Medicine, Zhejiang, China.|Department of Gynaecology, Hangzhou Hospital of Traditional Chinese Medicine, Zhejiang, China.
authors.forename: Yiyun
authors.initials: Y
authors.lastname: Lou
authors.affiliation: Department of Reproductive Endocrinology, Women's Hospital, Zhejiang University School of Medicine, Zhejiang, China.
authors.forename: Minhao
authors.initials: M
authors.lastname: Hu
authors.affiliation: Department of Reproductive Endocrinology, Women's Hospital, Zhejiang University School of Medicine, Zhejiang, China.
authors.forename: Luna
authors.initials: L
authors.lastname: Mao
authors.affiliation: Department of Reproductive Endocrinology, Women's Hospital, Zhejiang University School of Medicine, Zhejiang, China.
authors.forename: Yingming
authors.initials: Y
authors.lastname: Zheng
authors.affiliation: Department of Reproductive Endocrinology, Women's Hospital, Zhejiang University School of Medicine, Zhejiang, China; jinfan@zju.edu.cn.|Department of Biochemistry and Genetics, Zhejiang University School of Medicine, Zhejiang, China.|Key Laboratory of Reproductive Genetics, National Ministry of Education, Zhejiang University, Zhejiang, China.|Women's Reproductive Health Laboratory of Zhejiang Province, National Ministry of Education, Zhejiang University, Zhejiang, China.
authors.forename: Fan
authors.initials: F
authors.lastname: Jin
mesh_terms: D005260:Female; D015971:Gene Expression Regulation, Enzymologic / Q000502:physiology*; D006801:Humans; D017874:Immediate-Early Proteins / Q000235:genetics / Q000378:metabolism*; D007246:Infertility / Q000201:enzymology* / Q000235:genetics / Q000378:metabolism*; D011247:Pregnancy; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000378:metabolism*; D015222:Sodium Channels; D000099184:Serum-Glucocorticoid Regulated Kinases
chemical_list: D017874:Immediate-Early Proteins; D017346:Protein Serine-Threonine Kinases; D015222:Sodium Channels; D000099184:Serum-Glucocorticoid Regulated Kinases
keywords: SGK1; embryo implantation; endometriosis; infertility; spontaneous abortion