title: An individualised signature for predicting response with concordant survival benefit for lung adenocarcinoma patients receiving platinum-based chemotherapy.
abstract: BACKGROUND
  For lung adenocarcinoma (LUAD) patients receiving platinum-based adjuvant chemotherapy (ACT), predictive signatures extracted from survival data solely are not directly associated with platinum response. Another limitation of reported signatures, commonly based on risk scores summarised from gene expressions, is that they could not be applied directly to samples measured by different laboratories due to experimental batch effects.
  
  
  METHODS
  Using 60 samples of LUAD patients receiving platinum-based ACT in TCGA, we pre-selected gene pairs whose within-samples relative expression orderings (REOs) were significantly associated with both pathological response and 5-year survival, from which we selected an optimal signature whose within-samples REOs could identify responders with improved 5-year survival rate.
  
  
  RESULTS
  A predictive signature consisting of three gene pairs was developed. In an independent data set integrated from five small data sets, the predicted responders had a significantly higher 5-year survival rate than the predicted non-responders if and only if they received platinum-based ACT (log-rank P=0.0006). The predicted responders showed a 22% absolute benefit of platinum-based ACT in 5-year survival rate compared with untreated patients (log-rank P=0.0019).
  
  
  CONCLUSIONS
  The REO-based signature can individually predict response to platinum-based ACT with concordant survival benefit directly for LUAD samples measured by different laboratories.
authors.affiliation: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150086, China.
authors.forename: Lishuang
authors.initials: L
authors.lastname: Qi
authors.affiliation: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150086, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Li
authors.affiliation: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150086, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Qin
authors.affiliation: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150086, China.
authors.forename: Gengen
authors.initials: G
authors.lastname: Shi
authors.affiliation: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150086, China.
authors.forename: Tianhao
authors.initials: T
authors.lastname: Li
authors.affiliation: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150086, China.
authors.forename: Jiasheng
authors.initials: J
authors.lastname: Wang
authors.affiliation: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150086, China.
authors.forename: Libin
authors.initials: L
authors.lastname: Chen
authors.affiliation: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150086, China.
authors.forename: Yunyan
authors.initials: Y
authors.lastname: Gu
authors.affiliation: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150086, China.
authors.forename: Wenyuan
authors.initials: W
authors.lastname: Zhao
authors.affiliation: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150086, China.|Key Laboratory of Ministry of Education for Gastrointestinal Cancer, Department of Bioinformatics, Fujian Medical University, Fuzhou 350001, China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Guo
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000235:genetics; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D020869:Gene Expression Profiling; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000235:genetics; D009944:Organoplatinum Compounds / Q000627:therapeutic use*; D015996:Survival Rate
chemical_list: D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds