title: How a High-Gradient Magnetic Field Could Affect Cell Life.
abstract: The biological effects of high-gradient magnetic fields (HGMFs) have steadily gained the increased attention of researchers from different disciplines, such as cell biology, cell therapy, targeted stem cell delivery and nanomedicine. We present a theoretical framework towards a fundamental understanding of the effects of HGMFs on intracellular processes, highlighting new directions for the study of living cell machinery: changing the probability of ion-channel on/off switching events by membrane magneto-mechanical stress, suppression of cell growth by magnetic pressure, magnetically induced cell division and cell reprograming, and forced migration of membrane receptor proteins. By deriving a generalized form for the Nernst equation, we find that a relatively small magnetic field (approximately 1 T) with a large gradient (up to 1 GT/m) can significantly change the membrane potential of the cell and thus have a significant impact on not only the properties and biological functionality of cells but also cell fate.
authors.affiliation: Department of Optical and Biophysical Systems, Institute of Physics of the Academy of Sciences of the Czech Republic, Prague, 18221, Czech Republic.
authors.forename: Vitalii
authors.initials: V
authors.lastname: Zablotskii
authors.affiliation: Department of Optical and Biophysical Systems, Institute of Physics of the Academy of Sciences of the Czech Republic, Prague, 18221, Czech Republic.
authors.forename: Tatyana
authors.initials: T
authors.lastname: Polyakova
authors.affiliation: Department of Optical and Biophysical Systems, Institute of Physics of the Academy of Sciences of the Czech Republic, Prague, 18221, Czech Republic.
authors.forename: Oleg
authors.initials: O
authors.lastname: Lunov
authors.affiliation: Department of Optical and Biophysical Systems, Institute of Physics of the Academy of Sciences of the Czech Republic, Prague, 18221, Czech Republic.
authors.forename: Alexandr
authors.initials: A
authors.lastname: Dejneka
mesh_terms: D004574:Electromagnetic Fields; D006801:Humans; D055909:Magnetic Field Therapy; D008564:Membrane Potentials / Q000528:radiation effects; D008962:Models, Theoretical; D050997:Nanomedicine; D013234:Stem Cells / Q000528:radiation effects*