title: Codon usage pattern and prediction of gene expression level in Bungarus species.
abstract: Codon bias study in an organism gains significance in understanding the molecular mechanism as well as the functional conservation of gene expression during the course of evolution. The prime focus in this study is to compare the codon usage patterns among the four species belonging to the genus Bungarus (B. multicinctus, B. fasciatus, B. candidus and B. flaviceps) using several codon bias parameters. Our results suggested that relatively low codon bias exists in the coding sequences of the selected species. The compositional constraints together with gene expression level might influence the patterns of codon usage among the genes of Bungarus species. Both natural selection and mutation pressure affect the codon usage pattern in Bungarus species as evident from correspondence analysis. Neutrality plot indicates that natural selection played a major role while mutation pressure played a minor role in codon usage pattern of the genes in Bungarus species.
authors.affiliation: Department of Biotechnology, Assam University, Silchar, Assam 788011, India. Electronic address: supriyoch_2008@rediffmail.com.
authors.forename: Supriyo
authors.initials: S
authors.lastname: Chakraborty
authors.affiliation: Department of Biotechnology, Assam University, Silchar, Assam 788011, India.
authors.forename: Debojyoti
authors.initials: D
authors.lastname: Nag
authors.affiliation: Department of Biotechnology, Assam University, Silchar, Assam 788011, India.
authors.forename: Tarikul Huda
authors.initials: TH
authors.lastname: Mazumder
authors.affiliation: Department of Biotechnology, Assam University, Silchar, Assam 788011, India; Moinul Hoque Choudhury Memorial Science College, Algapur, HailaKandi, Assam 788150, India.
authors.forename: Arif
authors.initials: A
authors.lastname: Uddin
mesh_terms: D000818:Animals; D005075:Biological Evolution; D017838:Bungarus / Q000145:classification / Q000235:genetics*; D003062:Codon / Q000737:chemistry / Q000378:metabolism*; D005786:Gene Expression Regulation; D059014:High-Throughput Nucleotide Sequencing; D008957:Models, Genetic; D009154:Mutation; D010802:Phylogeny; D011506:Proteins / Q000235:genetics* / Q000378:metabolism; D012641:Selection, Genetic
chemical_list: D003062:Codon; D011506:Proteins
keywords: Bungarus; Codon adaptation index; Codon usage; Effective number of codon; Relative synonymous codon usage; Synonymous codon