title: WRNIP1: A new guardian of genome integrity at stalled replication forks.
abstract: Failure to protect and/or restart stalled replication forks contributes to genomic instability. Radiation-sensitive 51 (RAD51) recombinase defends stalled forks from nucleolytic attack, which otherwise can threaten their integrity. Recently, we have uncovered a novel and key function of Werner helicase interacting protein 1 (WRNIP1) as a fork-protective factor working in conjunction with RAD51 in response to replication stress.
authors.affiliation: Section of Molecular Epidemiology, Istituto Superiore di Sanità , Rome, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Leuzzi
authors.affiliation: Section of Molecular Epidemiology, Istituto Superiore di Sanità , Rome, Italy.
authors.forename: Veronica
authors.initials: V
authors.lastname: Marabitti
authors.affiliation: Department of Environment and Primary Prevention, Section of Experimental and Computational Carcinogenesis, Istituto Superiore di Sanità , Rome, Italy.
authors.forename: Pietro
authors.initials: P
authors.lastname: Pichierri
authors.affiliation: Section of Molecular Epidemiology, Istituto Superiore di Sanità , Rome, Italy.
authors.forename: Annapaola
authors.initials: A
authors.lastname: Franchitto
keywords: Genome instability; WRNIP1; replication fork stalling; replication stress