title: Phylogenetic and Functional Classification of the Photolyase/Cryptochrome Family.
abstract: The photolyase/cryptochrome (PHR/CRY) family is a large group of proteins with similar structure but very diverge functions such as DNA repair, circadian clock resetting and regulation of transcription. As a result of advances in the biochemistry of the CRY/PHR family and identification of new members, several adjustments have been made to the classification of this protein family. For example, a new class of PHRs, Class III, has been proposed. Furthermore, CRYs have been suggested to function as photosensory proteins in the primordial eye of sponge larvae. Additionally, a magnetosensory function has been attributed to certain CRYs. Recent advances in the field enabled us to propose a comprehensive classification scheme and nomenclatural system for this family. This review focuses on the computational and biochemical classifications of the PHR/CRY family. Several examples show that computational analysis can give a hinge about the function of newly discovered members before performing any biochemical study.
authors.affiliation: Department of Molecular Biology and Genetics, Gebze Technical University, Gebze, Kocaeli, Turkey.
authors.forename: Nuri
authors.identifier: 0000-0001-5206-4127
authors.initials: N
authors.lastname: Ozturk
mesh_terms: D000818:Animals; D002940:Circadian Rhythm; D056931:Cryptochromes / Q000737:chemistry* / Q000145:classification; D004255:Deoxyribodipyrimidine Photo-Lyase / Q000737:chemistry* / Q000145:classification; D007814:Larva / Q000254:growth & development; D010802:Phylogeny; D011161:Porifera / Q000254:growth & development / Q000502:physiology
chemical_list: D056931:Cryptochromes; D004255:Deoxyribodipyrimidine Photo-Lyase