title: Mapping the 3D genome: Aiming for consilience.
abstract: The spatial organization of genomes is studied using microscopy- and chromosome conformation capture (3C)-based methods. The two types of methods produce data that are often consistent, but there are cases where they appear discordant. These cases provide opportunities to derive better models of chromatin folding, which can reconcile the datasets.
authors.affiliation: Howard Hughes Medical Institute, Program in Systems Biology, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 368 Plantation Street, Worcester, Massachusetts 01605-0103, USA.
authors.forename: Job
authors.initials: J
authors.lastname: Dekker
mesh_terms: D002874:Chromosome Mapping; D002875:Chromosomes / Q000648:ultrastructure*; D056426:Genetic Loci; D015894:Genome, Human; D006801:Humans; D009690:Nucleic Acid Conformation