title: Altered resting-state regional homogeneity after 13 weeks of paliperidone injection treatment in schizophrenia patients.
abstract: This study aimed to explore the effects of the long-acting antipsychotic drug palmitate paliperidone in resting-state brain activity of schizophrenia patients. Seventeen schizophrenia outpatients were included and received palmitate paliperidone injection (PAL) treatment for 13 weeks. These patients were compared to seventeen matched healthy controls. All subjects underwent two scan sessions of resting-state magnetic resonance imaging (baseline and the 13th week) and regional homogeneity (ReHo) at resting-state where compared. After 13 weeks of treatment, PAL increased ReHo of the prefrontal cortex, anterior cingulate gyrus and orbital frontal gyrus, while PAL decreased ReHo of the thalamus, parahippocampal gyrus and superior temporal gyrus. Furthermore, improvement of psychiatric symptoms correlated with changing amplitude of ReHo: positively correlated with postcentral gyrus and negatively correlated with the occipital cortex. Baseline ReHo values of the middle occipital gyrus were positively correlated with the rate of reduction of psychiatric symptoms and improvement of social function. These results suggested that PAL might achieve its clinical effect in schizophrenia by influencing the resting-state function of the occipital cortex, lateral prefrontal cortex and temporal lobe. Baseline function of the inferior occipital gyrus might potentially predict the short-term effect of PAL in schizophrenia.
authors.affiliation: Department of Psychiatry, First Affiliated Hospital of Kunming Medical University, Kunming, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Bai
authors.affiliation: Department of Psychiatry, First Affiliated Hospital of Kunming Medical University, Kunming, China.
authors.forename: Weixin
authors.initials: W
authors.lastname: Wang
authors.affiliation: Department of Internal Medicine, First Affiliated Hospital of Kunming Medical University, Kunming, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Xu
authors.affiliation: Magnetic Resonance Imaging Center, First Affiliated Hospital of Kunming Medical University, Kunming, China.
authors.forename: Fengrui
authors.initials: F
authors.lastname: Zhang
authors.affiliation: Magnetic Resonance Imaging Center, First Hospital of Kunming City, Kunming, China.
authors.forename: Hongjun
authors.initials: H
authors.lastname: Yu
authors.affiliation: Magnetic Resonance Imaging Center, First Hospital of Kunming City, Kunming, China.
authors.forename: Chunrong
authors.initials: C
authors.lastname: Luo
authors.affiliation: School of Life Sciences, Tsinghua University, Beijing, China.
authors.forename: Lianzhang
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Psychiatry, First Affiliated Hospital of Kunming Medical University, Kunming, China.
authors.forename: Xianyu
authors.initials: X
authors.lastname: Chen
authors.affiliation: Key Laboratory of Nuclear Analysis Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, China.
authors.forename: Baoci
authors.initials: B
authors.lastname: Shan
authors.affiliation: Key Laboratory of Animal Models and Human Disease Mechanisms, Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Xu
authors.affiliation: Department of Psychiatry, First Affiliated Hospital of Kunming Medical University, Kunming, China.
authors.forename: Xiufeng
authors.initials: X
authors.lastname: Xu
authors.affiliation: Department of Psychiatry, First Affiliated Hospital of Kunming Medical University, Kunming, China. Electronic address: yuqich@163.com.
authors.forename: Yuqi
authors.initials: Y
authors.lastname: Cheng
mesh_terms: D000293:Adolescent; D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001921:Brain / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D000068882:Paliperidone Palmitate / Q000627:therapeutic use*; D012559:Schizophrenia / Q000188:drug therapy / Q000503:physiopathology*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D014150:Antipsychotic Agents; D000068882:Paliperidone Palmitate
keywords: Antipsychotics; Paliperidone palmitate; ReHo; Resting state fMRI; Schizophrenia