title: Evaluation of salivary oxidate stress biomarkers, nitric oxide and C-reactive protein in patients with oral lichen planus and burning mouth syndrome.
abstract: OBJECTIVE
  The aim of this study was to evaluate oxidative stress factors and C-reactive protein in the saliva of patients with oral lichen planus (OLP) and burning mouth syndrome (BMS).
  
  
  METHODS
  This consecutive, cross-sectional study included 20 patients with OLP, 19 with burning mouth syndrome (BMS), and 31 control subjects. The oral cavity of each patient was examined and patients responded to a quality of life questionnaire (OHIP-14) and the xerostomia inventory. The following parameters were measured in whole non-stimulated saliva: trolox equivalent antioxidant capacity (TEAC); total antioxidant capacity (TAC); cupric reducing antioxidant capacity (CUPRAC); ferric reducing ability of plasma (FRAP); C-reactive protein (CRP); nitric oxide; nitrates; and nitrites.
  
  
  RESULTS
  The OLP group presented statistically significant differences in reactive oxygen species (ROS) (29 600 cps) in comparison with the control group (39 679 cps) (P < 0.05). In the BMS group, ROS was 29 707 cps with significant difference in comparison with the control group (P < 0.05). Significantly higher salivary nitric oxide (145.7 μmol) and nitrite (141.0 μmol) levels were found in OLP patients in comparison with control group (P < 0.05).
  
  
  CONCLUSIONS
  Increases in nitric oxide and C-reactive protein were found in the saliva of OLP patients in comparison with BMS and control patients. Further studies are required to confirm these findings.
authors.affiliation: Interdisciplinary Laboratory of Clinical Analysis Interlab-UMU, Faculty of Veterinary Medicine, Regional Campus of International Excellence Campus Mare Nostrum, University of Murcia, Espinardo, Murcia, Spain.|Department of Animal Medicine and Surgery, Veterinary School, the Autonomous University of Barcelona, Barcelona, Spain.
authors.forename: Asta
authors.initials: A
authors.lastname: Tvarijonaviciute
authors.affiliation: Department of Oral Medicine, Faculty of Medicine, University of Murcia, Espinardo, Murcia, Spain.
authors.forename: Cristina
authors.initials: C
authors.lastname: Aznar-Cayuela
authors.affiliation: Interdisciplinary Laboratory of Clinical Analysis Interlab-UMU, Faculty of Veterinary Medicine, Regional Campus of International Excellence Campus Mare Nostrum, University of Murcia, Espinardo, Murcia, Spain.
authors.forename: Camila P
authors.initials: CP
authors.lastname: Rubio
authors.affiliation: Interdisciplinary Laboratory of Clinical Analysis Interlab-UMU, Faculty of Veterinary Medicine, Regional Campus of International Excellence Campus Mare Nostrum, University of Murcia, Espinardo, Murcia, Spain.
authors.forename: José J
authors.initials: JJ
authors.lastname: Ceron
authors.affiliation: Department of Oral Medicine, Faculty of Medicine, University of Murcia, Espinardo, Murcia, Spain.
authors.forename: Pia
authors.initials: P
authors.lastname: López-Jornet
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000032:analysis; D002054:Burning Mouth Syndrome / Q000378:metabolism*; D002097:C-Reactive Protein / Q000032:analysis*; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D017676:Lichen Planus, Oral / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000032:analysis*; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000032:analysis; D012463:Saliva / Q000737:chemistry*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D017382:Reactive Oxygen Species; D009569:Nitric Oxide; D002097:C-Reactive Protein
keywords: antioxidant capacity; burning mouth syndrome; markers of oxidative stress; oral lichen planus; saliva