title: Biodegradable polymeric nanoparticles containing gold nanoparticles and Paclitaxel for cancer imaging and drug delivery using photoacoustic methods.
abstract: In this study, optical-triggered multifunctional theranostic agents for photoacoustic/fluorescent imaging and cancer therapy have been developed. This system consists of a perfluorohexane liquid and gold nanoparticles (GNPs) in the core, stabilized by a Poly (lactide-co-glycolic acid) (PLGA) polymer shell. When cancer cells containing PLGA-GNPs were exposed to laser pulses, cell viability decreased due to the vaporization of the particles in and around the cells. The particle chemo drug loading and delivery capacity was also investigated in vitro experiments. These particles show potential as photoacoustic imaging and therapy agents for future clinical translation in cancer therapy.
authors.affiliation: Physics Department, Ryerson University, 350 Victoria St., Toronto, Ontario M5B 2K3, Canada; Institute for Biomedical Engineering, Science and Technology (iBEST), a partnership between Ryerson University and St. Michael's Hospital, 30 Bond St., Toronto, Ontario, M5B 1T8, Canada; Keenan Research Centre for Biomedical Science of St. Michael's Hospital, 30 Bond St., Toronto, Ontario, M5B 1T8, Canada.
authors.forename: Yanjie
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Physics Department, Ryerson University, 350 Victoria St., Toronto, Ontario M5B 2K3, Canada; Institute for Biomedical Engineering, Science and Technology (iBEST), a partnership between Ryerson University and St. Michael's Hospital, 30 Bond St., Toronto, Ontario, M5B 1T8, Canada; Keenan Research Centre for Biomedical Science of St. Michael's Hospital, 30 Bond St., Toronto, Ontario, M5B 1T8, Canada.
authors.forename: Eric M
authors.initials: EM
authors.lastname: Strohm
authors.affiliation: Institute of Ultrasound Imaging, Second Affiliated Hospital, Chongqing Medical University, 76 Linjiang Rd., Chongqing, 400010, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Department of Ultrasound, Children's Hospital, Affiliated to Chongqing Medical University, No.136, Zhongshan No.2 Rd., Yuzhong District, Chongqing 400014, China.
authors.forename: Zhaoxia
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Ultrasound Department, Sixth affiliated hospital of Shanghai Jiaotong University, 600 Yishan Rd., Xuhui District, Shanghai, 200133, China.
authors.forename: Yuanyi
authors.initials: Y
authors.lastname: Zheng
authors.affiliation: Institute of Ultrasound Imaging, Second Affiliated Hospital, Chongqing Medical University, 76 Linjiang Rd., Chongqing, 400010, China.
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Physics Department, Ryerson University, 350 Victoria St., Toronto, Ontario M5B 2K3, Canada; Institute for Biomedical Engineering, Science and Technology (iBEST), a partnership between Ryerson University and St. Michael's Hospital, 30 Bond St., Toronto, Ontario, M5B 1T8, Canada; Keenan Research Centre for Biomedical Science of St. Michael's Hospital, 30 Bond St., Toronto, Ontario, M5B 1T8, Canada.
authors.forename: Michael C
authors.initials: MC
authors.lastname: Kolios
keywords: (160.1435) Biomaterials; (160.4236) Nanomaterials; (170.2520) Fluorescence microscopy; (170.3880) Medical and biological imaging; (170.5120) Photoacoustic imaging