title: Pentraxin 3 and other inflammatory biomarkers related to atrial fibrillation in cardiac surgery.
abstract: OBJECTIVE
  The aim was to evaluate the association between perioperative inflammatory biomarkers and atrial fibrillation (AF) in cardiac surgical patients.
  
  
  METHODS
  Forty-two patients undergoing cardiac surgery were divided into three groups according to the occurrence of AF: Group A (n = 22) - patients with no AF, Group B (n = 11) - patients with new onset AF postoperatively and Group C (n = 9) - patients with preoperative history of atrial fibrillation. The serum levels of PTX3, CRP, TLR2, IL-8, IL-18, sFas, MMP-7 and MMP-8 were measured at the following time points: before surgery, immediately and 6 h after surgery and on the 1st, 3rdand 7thpostoperative days (POD).
  
  
  RESULTS
  Serum levels of PTX3 showed a significant difference between Groups A and C on the 3rdPOD (p<0.05) and on the 7thPOD (p<0.0001). IL-8 levels were different between Groups A and C immediately after surgery (p<0.05), 6 hours after surgery (p<0.05) and on the 3rdPOD (p<0.05). There was a difference between Groups B and C on the 1stPOD in IL-8 levels (p<0.05). The sFas levels differed between Groups A and C on the 3rdPOD (p<0.01) and the 7thPOD (p<0.05). There was also a difference on the 7thPOD (p<0.05) between the Groups B and C. No significant differences between the groups was seen for other biomarkers.
  
  
  CONCLUSIONS
  This study demonstrates significantly different dynamics of PTX3, IL-8 and sFas levels after cardiac surgery in relation to AF.
authors.affiliation: 1 Department of Cardiac Surgery, Charles University in Prague, Faculty of Medicine and University Hospital Hradec Kralove, Hradec Kralove, Czech Republic.|2 Department of Cardiac Surgery, Kerckhoff Heart and Lung Centre, Bad Nauheim, Germany.
authors.forename: Zdenka
authors.initials: Z
authors.lastname: Holubcova
authors.affiliation: 1 Department of Cardiac Surgery, Charles University in Prague, Faculty of Medicine and University Hospital Hradec Kralove, Hradec Kralove, Czech Republic.
authors.forename: Pavel
authors.initials: P
authors.lastname: Kunes
authors.affiliation: 1 Department of Cardiac Surgery, Charles University in Prague, Faculty of Medicine and University Hospital Hradec Kralove, Hradec Kralove, Czech Republic.
authors.forename: Jiri
authors.initials: J
authors.lastname: Mandak
authors.affiliation: 1 Department of Cardiac Surgery, Charles University in Prague, Faculty of Medicine and University Hospital Hradec Kralove, Hradec Kralove, Czech Republic.
authors.forename: Dana
authors.initials: D
authors.lastname: Vlaskova
authors.affiliation: 3 Department of Clinical Immunology and Allergology, Charles University in Prague, Faculty of Medicine and University Hospital Hradec Kralove, Hradec Kralove, Czech Republic.
authors.forename: Martina
authors.initials: M
authors.lastname: Kolackova
authors.affiliation: 3 Department of Clinical Immunology and Allergology, Charles University in Prague, Faculty of Medicine and University Hospital Hradec Kralove, Hradec Kralove, Czech Republic.
authors.forename: Drahomira
authors.initials: D
authors.lastname: Holmannova
authors.affiliation: 3 Department of Clinical Immunology and Allergology, Charles University in Prague, Faculty of Medicine and University Hospital Hradec Kralove, Hradec Kralove, Czech Republic.
authors.forename: Ctirad
authors.initials: C
authors.lastname: Andrys
authors.affiliation: 3 Department of Clinical Immunology and Allergology, Charles University in Prague, Faculty of Medicine and University Hospital Hradec Kralove, Hradec Kralove, Czech Republic.
authors.forename: Jan
authors.initials: J
authors.lastname: Krejsek
authors.affiliation: 1 Department of Cardiac Surgery, Charles University in Prague, Faculty of Medicine and University Hospital Hradec Kralove, Hradec Kralove, Czech Republic.|2 Department of Cardiac Surgery, Kerckhoff Heart and Lung Centre, Bad Nauheim, Germany.
authors.forename: Tomas
authors.initials: T
authors.lastname: Holubec
mesh_terms: D000368:Aged; D001281:Atrial Fibrillation / Q000097:blood* / Q000601:surgery; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism*; D006348:Cardiac Surgical Procedures; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000683:Serum Amyloid P-Component / Q000378:metabolism*; D000099153:Pentraxins
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein; D000683:Serum Amyloid P-Component; D000099153:Pentraxins
keywords: atrial fibrillation; biomarker; cardiac surgery; inflammation; pentraxin 3