title: Pharmacokinetics and Safety of Defibrotide in Healthy Japanese Subjects.
authors.affiliation: Department of Pharmacology, Hamamatsu University School of Medicine, Hamamatsu, Japan.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Umemura
authors.affiliation: Department of Pharmacology, Hamamatsu University School of Medicine, Hamamatsu, Japan.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Iwaki
authors.affiliation: Department of Pharmacy, Tokyo Women's Medical University Hospital, Tokyo, Japan.
authors.forename: Toshimi
authors.initials: T
authors.lastname: Kimura
authors.affiliation: Department of Pediatric Oncology, National Cancer Center Hospital, Tokyo, Japan.
authors.forename: Chitose
authors.initials: C
authors.lastname: Ogawa
authors.affiliation: Department of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Fukuda
authors.affiliation: Department of Hematology, Toranomon Hospital, Tokyo, Japan.
authors.forename: Shuichi
authors.initials: S
authors.lastname: Taniguchi
authors.affiliation: Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya, Japan.
authors.forename: Keizo
authors.initials: K
authors.lastname: Horibe
authors.affiliation: Division of Hemato-Oncology/Regenerative Medicine, Kanagawa Children's Medical Center, Yokohama, Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Goto
authors.affiliation: Innovative Clinical Research Center, Kanazawa University, Kanazawa, Japan.
authors.forename: Kenichi
authors.initials: K
authors.lastname: Yoshimura
authors.affiliation: Clinical Trial Support Center, National Cancer Center Hospital East, Tokyo, Japan.
authors.forename: Yasutaka
authors.initials: Y
authors.lastname: Watanabe
authors.affiliation: Department of Pediatric Oncology, National Cancer Center Hospital, Tokyo, Japan.
authors.forename: Chika
authors.initials: C
authors.lastname: Nitani
authors.affiliation: Department of Pediatric Oncology, Fukushima Medical University, Fukushima, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kikuta
mesh_terms: D000328:Adult; D005342:Fibrinolysis; D005343:Fibrinolytic Agents; D064368:Healthy Volunteers; D006801:Humans; D008297:Male; D011089:Polydeoxyribonucleotides / Q000493:pharmacokinetics*; D055815:Young Adult
chemical_list: D005343:Fibrinolytic Agents; D011089:Polydeoxyribonucleotides; C036901:defibrotide
keywords: coagulation; defibrotide; drug safety; fibrinolysis; pharmacokinetics