title: A Philosophical Framework for Integrating Systems Pharmacology Models Into Pharmacometrics.
abstract: The framework for systems pharmacology style models does not naturally sit with the usual scientific dogma of parsimony and falsifiability based on deductive reasoning. This does not invalidate the importance or need for overarching models based on pharmacology to describe and understand complicated biological systems. However, it does require some consideration on how systems pharmacology fits into the overall scientific approach.
authors.affiliation: Otago Pharmacometrics Group, School of Pharmacy, University of Otago, Dunedin, New Zealand.
authors.forename: S B
authors.initials: SB
authors.lastname: Duffull
mesh_terms: D003198:Computer Simulation; D006801:Humans; D008962:Models, Theoretical; D010601:Pharmacology, Clinical / Q000379:methods*; D013597:Systems Analysis; D049490:Systems Biology; D018511:Systems Integration