title: Wide-field optical coherence micro-elastography for intraoperative assessment of human breast cancer margins.
abstract: Incomplete excision of malignant tissue is a major issue in breast-conserving surgery, with typically 20 - 30% of cases requiring a second surgical procedure arising from postoperative detection of an involved margin. We report advances in the development of a new intraoperative tool, optical coherence micro-elastography, for the assessment of tumor margins on the micro-scale. We demonstrate an important step by conducting whole specimen imaging in intraoperative time frames with a wide-field scanning system acquiring mosaicked elastograms with overall dimensions of ~50 × 50 mm, large enough to image an entire face of most lumpectomy specimens. This capability is enabled by a wide-aperture annular actuator with an internal diameter of 65 mm. We demonstrate feasibility by presenting elastograms recorded from freshly excised human breast tissue, including from a mastectomy, lumpectomies and a cavity shaving.
authors.affiliation: Optical + Biomedical Engineering Laboratory, School of Electrical, Electronic & Computer Engineering, The University of Western Australia, 35 Stirling Highway, Perth, WA 6009, Australia; BRITElab, Harry Perkins Institute of Medical Research, QEII Medical Centre, 6 Verdun Street, Nedlands, WA 6009, Australia.
authors.forename: Wes M
authors.initials: WM
authors.lastname: Allen
authors.affiliation: Optical + Biomedical Engineering Laboratory, School of Electrical, Electronic & Computer Engineering, The University of Western Australia, 35 Stirling Highway, Perth, WA 6009, Australia; BRITElab, Harry Perkins Institute of Medical Research, QEII Medical Centre, 6 Verdun Street, Nedlands, WA 6009, Australia.
authors.forename: Lixin
authors.initials: L
authors.lastname: Chin
authors.affiliation: Optical + Biomedical Engineering Laboratory, School of Electrical, Electronic & Computer Engineering, The University of Western Australia, 35 Stirling Highway, Perth, WA 6009, Australia.
authors.forename: Philip
authors.initials: P
authors.lastname: Wijesinghe
authors.affiliation: Optical + Biomedical Engineering Laboratory, School of Electrical, Electronic & Computer Engineering, The University of Western Australia, 35 Stirling Highway, Perth, WA 6009, Australia; Centre for Nanoscale BioPhotonics, Faculty of Health Science, University of Adelaide, Adelaide, SA 5005, Australia.
authors.forename: Rodney W
authors.initials: RW
authors.lastname: Kirk
authors.affiliation: PathWest, Fiona Stanley Hospital, 11 Robin Warren Drive, Murdoch, WA 6150, Australia.
authors.forename: Bruce
authors.initials: B
authors.lastname: Latham
authors.affiliation: Optical + Biomedical Engineering Laboratory, School of Electrical, Electronic & Computer Engineering, The University of Western Australia, 35 Stirling Highway, Perth, WA 6009, Australia; Centre for Microscopy, Characterisation & Analysis, The University of Western Australia, 35 Stirling Highway, Perth, WA 6009, Australia.
authors.forename: David D
authors.initials: DD
authors.lastname: Sampson
authors.affiliation: School of Surgery, The University of Western Australia, 35 Stirling Highway, Perth, WA 6009, Australia; Breast Centre, Fiona Stanley Hospital, 11 Robin Warren Drive, Murdoch, WA 6150, Australia; Breast Clinic, Royal Perth Hospital, 197 Wellington Street, Perth, WA 6000, Australia.
authors.forename: Christobel M
authors.initials: CM
authors.lastname: Saunders
authors.affiliation: Optical + Biomedical Engineering Laboratory, School of Electrical, Electronic & Computer Engineering, The University of Western Australia, 35 Stirling Highway, Perth, WA 6009, Australia; BRITElab, Harry Perkins Institute of Medical Research, QEII Medical Centre, 6 Verdun Street, Nedlands, WA 6009, Australia.
authors.forename: Brendan F
authors.initials: BF
authors.lastname: Kennedy
keywords: (110.4500) Optical coherence tomography; (170.0170) Medical optics and biotechnology