title: Critical Material Attributes of Strip Films Loaded With Poorly Water-Soluble Drug Nanoparticles: II. Impact of Polymer Molecular Weight.
abstract: Recent work established polymer strip films as a robust platform for delivery of poorly water-soluble drug particles. However, a simple means of manipulating rate of drug release from films with minimal impact on film mechanical properties has yet to be demonstrated. This study explores the impact of film-forming polymer molecular weight (MW) and concentration on properties of polymer films loaded with poorly water-soluble drug nanoparticles. Nanoparticles of griseofulvin, a model Biopharmaceutics Classification System class II drug, were prepared in aqueous suspension via wet stirred media milling. Aqueous solutions of 3 viscosity grades of hydroxypropyl methylcellulose (14, 21, and 88 kDa) at 3 viscosity levels (∼9500, ∼12,000, and ∼22,000 cP) were mixed with drug suspension, cast, and dried to produce films containing griseofulvin nanoparticles. Few differences in film tensile strength or elongation at break were observed between films within each viscosity level regardless of polymer MW despite requiring up to double the time to achieve 100% drug release. This suggests film-forming polymer MW can be used to manipulate drug release with little impact on film mechanical properties by matching polymer solution viscosity. In addition, changing polymer MW and concentration had no negative impact on drug content uniformity or nanoparticle redispersibility.
authors.affiliation: Otto H. York Department of Chemical, Biological, and Pharmaceutical Engineering, New Jersey Institute of Technology, Newark, New Jersey 07102.
authors.forename: Scott M
authors.initials: SM
authors.lastname: Krull
authors.affiliation: Otto H. York Department of Chemical, Biological, and Pharmaceutical Engineering, New Jersey Institute of Technology, Newark, New Jersey 07102.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Ammirata
authors.affiliation: Otto H. York Department of Chemical, Biological, and Pharmaceutical Engineering, New Jersey Institute of Technology, Newark, New Jersey 07102.
authors.forename: Sonia
authors.initials: S
authors.lastname: Bawa
authors.affiliation: Otto H. York Department of Chemical, Biological, and Pharmaceutical Engineering, New Jersey Institute of Technology, Newark, New Jersey 07102.
authors.forename: Meng
authors.initials: M
authors.lastname: Li
authors.affiliation: Otto H. York Department of Chemical, Biological, and Pharmaceutical Engineering, New Jersey Institute of Technology, Newark, New Jersey 07102.
authors.forename: Ecevit
authors.initials: E
authors.lastname: Bilgili
authors.affiliation: Otto H. York Department of Chemical, Biological, and Pharmaceutical Engineering, New Jersey Institute of Technology, Newark, New Jersey 07102. Electronic address: dave@njit.edu.
authors.forename: Rajesh N
authors.initials: RN
authors.lastname: Davé
mesh_terms: D000935:Antifungal Agents / Q000008:administration & dosage / Q000737:chemistry*; D065546:Drug Liberation; D006118:Griseofulvin / Q000008:administration & dosage / Q000737:chemistry*; D065347:Hypromellose Derivatives / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D012995:Solubility; D013718:Tensile Strength; D014783:Viscosity; D014867:Water / Q000737:chemistry
chemical_list: D000935:Antifungal Agents; D014867:Water; D006118:Griseofulvin; D065347:Hypromellose Derivatives
keywords: UV/vis spectroscopy; biodegradable polymers; content uniformity; controlled release/delivery; dissolution rate; formulation; nanoparticles; particle sizing; polymeric drug delivery systems; thermogravimetric analysis