title: Effect of Training Exercise on Urinary Brain-derived Neurotrophic Factor Levels and Cognitive Performances in Overweight and Obese Subjects.
abstract: Exercise-mediated, brain-derived neurotrophic factor induction benefits health and cognitive functions. The multifaceted interplay between physical activity, urinary brain-derived neurotrophic factor levels and cognitive functioning has been largely neglected in previous literature. In this pilot study, two bouts of training exercise (65% and 70% of heart rate reserve) influenced urinary brain-derived neurotrophic factor levels and cognitive performances in 12 overweight and obese participants. Percent heart rate reserve, expenditure energy, brain-derived neurotrophic factor urinary levels and cognitive performances were measured before and after the exercise. No significant variations in energy expenditure were observed, while differences of heart rate reserve between two groups were maintained. Both bouts of training exercise induced a similar reduction in urinary brain-derived neurotrophic factor levels. Only visuo-spatial working memory capacity at 65% of heart rate reserve showed a significant increase. These findings indicate a consistent effect of training exercise on urinary brain-derived neurotrophic factor levels and cognitive factors in overweight and obese participants.
authors.affiliation: Healthy Lifestyle Institute, Centro Universitario Ricerca Interdipartimentale Attivita Motoria (C.U.R.I.A.MO.), University of Perugia, Perugia, Italy.
authors.forename: Angelo
authors.initials: A
authors.lastname: Russo
authors.affiliation: Department of Philosophy, Social, University of Perugia, Perugia, Italy.
authors.forename: Livia
authors.initials: L
authors.lastname: Buratta
authors.affiliation: Healthy Lifestyle Institute, Centro Universitario Ricerca Interdipartimentale Attivita Motoria (C.U.R.I.A.MO.), University of Perugia, Perugia, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Pippi
authors.affiliation: Healthy Lifestyle Institute, Centro Universitario Ricerca Interdipartimentale Attivita Motoria (C.U.R.I.A.MO.), University of Perugia, Perugia, Italy.
authors.forename: Cristina
authors.initials: C
authors.lastname: Aiello
authors.affiliation: Healthy Lifestyle Institute, Centro Universitario Ricerca Interdipartimentale Attivita Motoria (C.U.R.I.A.MO.), University of Perugia, Perugia, Italy.
authors.forename: Claudia
authors.initials: C
authors.lastname: Ranucci
authors.affiliation: Healthy Lifestyle Institute, Centro Universitario Ricerca Interdipartimentale Attivita Motoria (C.U.R.I.A.MO.), University of Perugia, Perugia, Italy.
authors.forename: Elisa
authors.initials: E
authors.lastname: Reginato
authors.affiliation: Department of Philosophy, Social, University of Perugia, Perugia, Italy.
authors.forename: Valerio
authors.initials: V
authors.lastname: Santangelo
authors.affiliation: Healthy Lifestyle Institute, Centro Universitario Ricerca Interdipartimentale Attivita Motoria (C.U.R.I.A.MO.), University of Perugia, Perugia, Italy.
authors.forename: Pierpaolo
authors.initials: P
authors.lastname: DeFeo
authors.affiliation: Department of Philosophy, Social, University of Perugia, Perugia, Italy.
authors.forename: Claudia
authors.initials: C
authors.lastname: Mazzeschi
mesh_terms: D000328:Adult; D000368:Aged; D019208:Brain-Derived Neurotrophic Factor / Q000652:urine*; D003071:Cognition / Q000502:physiology*; D004734:Energy Metabolism / Q000502:physiology; D005081:Exercise Therapy; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology; D008875:Middle Aged; D009483:Neuropsychological Tests; D009765:Obesity / Q000523:psychology / Q000628:therapy* / Q000652:urine; D050177:Overweight / Q000523:psychology / Q000628:therapy* / Q000652:urine; D010865:Pilot Projects; D016896:Treatment Outcome
chemical_list: D019208:Brain-Derived Neurotrophic Factor
keywords: Brain-derived neurotrophic factor; cognitive functioning; physical activity; working memory