title: Taurine Treatment Modulates Circadian Rhythms in Mice Fed A High Fat Diet.
abstract: Close ties have been made among certain nutrients, obesity, type 2 diabetes and circadian clocks. Among nutrients, taurine has been documented as being effective against obesity and type 2 diabetes. However, the impact of taurine on circadian clocks has not been elucidated. We investigated whether taurine can modulate or correct disturbances in daily rhythms caused by a high-fat diet in mice. Male C57BL/6 mice were divided in four groups: control (C), control + taurine (C+T), high-fat diet (HFD) and HFD + taurine (HFD+T). They were administered 2% taurine in their drinking water for 10 weeks. Mice were euthanized at 6:00, 12:00, 18:00, and 24:00. HFD mice increased body weight, visceral fat and food intake, as well as higher levels of glucose, insulin and leptin, throughout the 24 h. Taurine prevented increments in food intake, body weight and visceral fat, improved glucose tolerance and insulin sensitivity and reduced disturbances in the 24 h patterns of plasma insulin and leptin. HFD downregulated the expression of clock genes Rev-erbα, Bmal1, and Per1 in pancreatic islets. Taurine normalized the gene and protein expression of PER1 in beta-cells, which suggests that it could be beneficial for the correction of daily rhythms and the amelioration of obesity and diabetes.
authors.affiliation: Diabetes and Obesity Research Laboratory, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
authors.forename: Ana Lucia C
authors.initials: AL
authors.lastname: Figueroa
authors.affiliation: Diabetes and Obesity Research Laboratory, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
authors.forename: Hugo
authors.initials: H
authors.lastname: Figueiredo
authors.affiliation: Diabetes and Obesity Research Laboratory, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.|CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Spain.
authors.forename: Sandra A
authors.initials: SA
authors.lastname: Rebuffat
authors.affiliation: CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Spain.|Postgraduate Program on Physical Education, Universidade Católica de Brasília-UCB, DF, Brazil.
authors.forename: Elaine
authors.initials: E
authors.lastname: Vieira
authors.affiliation: Diabetes and Obesity Research Laboratory, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.|CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Spain.|University of Barcelona, Faculty of Medicine, University of Barcelona, Barcelona, Spain.
authors.forename: Ramon
authors.initials: R
authors.lastname: Gomis
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002940:Circadian Rhythm / Q000187:drug effects*; D059305:Diet, High-Fat; D020869:Gene Expression Profiling; D050417:Insulin-Secreting Cells / Q000187:drug effects / Q000502:physiology; D008297:Male; D008810:Mice, Inbred C57BL; D056950:Period Circadian Proteins / Q000096:biosynthesis; D013654:Taurine / Q000008:administration & dosage*
chemical_list: C539023:Per1 protein, mouse; D056950:Period Circadian Proteins; D013654:Taurine