title: The advantageous role of annexin A1 in cardiovascular disease.
abstract: The inflammatory response protects the human body against infection and injury. However, uncontrolled and unresolved inflammation can lead to tissue damage and chronic inflammatory diseases. Therefore, active resolution of inflammation is essential to restore tissue homeostasis. This review focuses on the pro-resolving molecule annexin A1 (ANXA1) and its derived peptides. Mechanisms instructed by ANXA1 are multidisciplinary and affect leukocytes as well as endothelial cells and tissue resident cells like macrophages and mast cells. ANXA1 has an outstanding role in limiting leukocyte recruitment and different aspects of ANXA1 as modulator of the leukocyte adhesion cascade are discussed here. Additionally, this review details the therapeutic relevance of ANXA1 and its derived peptides in cardiovascular diseases since atherosclerosis stands out as a chronic inflammatory disease with impaired resolution and continuous leukocyte recruitment.
authors.affiliation: a Institute for Cardiovascular Prevention , Ludwig-Maximilians University , Munich , Germany.|b Department of Pathology , Academic Medical Center, Amsterdam University , Amsterdam , the Netherlands.
authors.forename: Renske
authors.initials: R
authors.lastname: de Jong
authors.affiliation: a Institute for Cardiovascular Prevention , Ludwig-Maximilians University , Munich , Germany.|b Department of Pathology , Academic Medical Center, Amsterdam University , Amsterdam , the Netherlands.
authors.forename: Giovanna
authors.initials: G
authors.lastname: Leoni
authors.affiliation: a Institute for Cardiovascular Prevention , Ludwig-Maximilians University , Munich , Germany.|b Department of Pathology , Academic Medical Center, Amsterdam University , Amsterdam , the Netherlands.|c DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance , Munich , Germany.
authors.forename: Maik
authors.initials: M
authors.lastname: Drechsler
authors.affiliation: a Institute for Cardiovascular Prevention , Ludwig-Maximilians University , Munich , Germany.|b Department of Pathology , Academic Medical Center, Amsterdam University , Amsterdam , the Netherlands.|c DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance , Munich , Germany.
authors.forename: Oliver
authors.initials: O
authors.lastname: Soehnlein
mesh_terms: D017305:Annexin A1 / Q000097:blood / Q000235:genetics*; D002318:Cardiovascular Diseases / Q000097:blood / Q000235:genetics* / Q000473:pathology; D002448:Cell Adhesion / Q000235:genetics*; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000235:genetics* / Q000473:pathology; D007962:Leukocytes / Q000473:pathology; D008264:Macrophages / Q000378:metabolism / Q000473:pathology; D010455:Peptides / Q000235:genetics
chemical_list: D017305:Annexin A1; D010455:Peptides
keywords: Ac2–26; annexin A1; atherosclerosis; cardiovascular diseases; leukocyte recruitment; myocardial infarction; resolution of inflammation; stroke