title: Socket preservation using freeze-dried bone allograft with and without plasma rich in growth factors in dogs.
abstract: BACKGROUND
  Plasma rich in growth factors (PRGF) and freeze-dried bone allograft (FDBA) are shown to promote bone healing. This study was aimed to histologically and histomorphometrically investigate the effect of combined use of PRGF and FDBA on bone formation, and compare it to FDBA alone and control group.
  
  
  METHODS
  The distal roots of the lower premolars were extracted bilaterally in four female dogs. Sockets were randomly divided into FDBA + PRGF, FDBA, and control groups. Two dogs were sacrificed after 2 weeks and two dogs were sacrificed after 4 weeks. Sockets were assessed histologically and histomorphometrically. Data were analyzed by Kruskal-Wallis test followed by Mann-Whitney U-tests utilizing the SPSS software version 20.P< 0.05 was considered statistically significant.
  
  
  RESULTS
  While the difference in density of fibrous tissue in three groups was not statistically significant (P= 0.343), the bone density in grafted groups was significantly higher than the control group (P= 0.021). The least decrease in all socket dimensions was observed in the FDBA group. However, these differences were only significant in coronal portion at week 4. Regarding socket dimensions and bone density, the difference between FDBA and FDBA+PRGF groups was not significant in middle and apical portions.
  
  
  CONCLUSIONS
  The superiority of PRGF+FDBA overFDBA in socket preservation cannot be concluded from this experiment.
authors.affiliation: Dental Implant Research Center and Department of Oral and Maxillofacial Surgery, School of Dentistry, Isfahan University of Medical Sciences, Sari, Mazandaran, Iran.
authors.forename: Mohammad Hasan
authors.initials: MH
authors.lastname: Samandari
authors.affiliation: Dental Implant Research Center and Department of Oral and Maxillofacial Surgery, School of Dentistry, Isfahan University of Medical Sciences, Sari, Mazandaran, Iran.
authors.forename: Abbas
authors.initials: A
authors.lastname: Haghighat
authors.affiliation: Dental Materials Research Center and Department of Oral Pathology, School of Dentistry, Isfahan University of Medical Sciences, Sari, Mazandaran, Iran.
authors.forename: Nakisa
authors.initials: N
authors.lastname: Torabinia
authors.affiliation: Department of Oral and Maxillofacial Surgery, School of Dentistry, Mazandaran University of Medical Sciences, Sari, Mazandaran, Iran.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Taghian
authors.affiliation: Dental Research Center and Department of Pediatric Dentistry, Students Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Leyli
authors.initials: L
authors.lastname: Sadri
authors.affiliation: Department of Oral and Maxillofacial Surgery, Golestan University of Medical Sciences, Gorgan, Iran.
authors.forename: Vahid
authors.initials: V
authors.lastname: Naemy
keywords: Allografts; platelet-rich plasma; socket graft