title: Contribution of Maternal Immunity to Decreased Rotavirus Vaccine Performance in Low- and Middle-Income Countries.
abstract: The role of maternal immunity, received by infants either transplacentally or orally from breast milk, in rotavirus vaccine (RV) performance is evaluated here. Breastfeeding withholding has no effect on vaccine responses, but higher levels of transplacental rotavirus-specific IgG antibody contribute to reduced vaccine seroconversion. The gaps in knowledge on the factors associated with low RV efficacy in low- and middle-income countries (LMIC) remain, and further research is needed to shed more light on these issues.
authors.affiliation: Centre for Infectious Disease Research in Zambia, Lusaka, Zambia.
authors.forename: Katayi
authors.initials: K
authors.lastname: Mwila
authors.affiliation: Centre for Infectious Disease Research in Zambia, Lusaka, Zambia Roma.Chilengi@cidrz.org sbd@unc.edu.|Department of Family Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
authors.forename: Roma
authors.initials: R
authors.lastname: Chilengi
authors.affiliation: Centre for Infectious Disease Research in Zambia, Lusaka, Zambia.
authors.forename: Michelo
authors.initials: M
authors.lastname: Simuyandi
authors.affiliation: Department of Pediatrics, Human Vaccine Institute, Duke University, Durham, North Carolina, USA.
authors.forename: Sallie R
authors.initials: SR
authors.lastname: Permar
authors.affiliation: Department of Family Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA Roma.Chilengi@cidrz.org sbd@unc.edu.
authors.forename: Sylvia
authors.initials: S
authors.lastname: Becker-Dreps
mesh_terms: D000914:Antibodies, Viral / Q000097:blood; D003906:Developing Countries; D006801:Humans; D007112:Immunity, Maternally-Acquired; D007074:Immunoglobulin G / Q000097:blood; D012400:Rotavirus Infections / Q000276:immunology / Q000517:prevention & control*; D022243:Rotavirus Vaccines / Q000008:administration & dosage* / Q000276:immunology*; D016896:Treatment Outcome
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G; D022243:Rotavirus Vaccines
keywords: immunization; low- and middle-income countries; maternal; rotavirus