title: The roles of ebolavirus glycoproteins in viral pathogenesis.
abstract: Ebolaviruses are highly dangerous pathogens exhibiting extreme virulence in humans and nonhuman primates. The majority of ebolavirus species, most notably Zaire ebolavirus, can cause Ebola virus disease (EVD), formerly known as Ebola hemorrhagic fever, in humans. EVD is associated with case-fatality rates as high as 90%, and there is currently no specific treatment or licensed vaccine available against EVD. Understanding the molecular biology and pathogenesis of ebolaviruses is important for the development of antiviral therapeutics. Ebolavirus encodes several forms of glycoproteins (GPs), which have some interesting characteristics, including the transcriptional editing coding strategy and extensive O-glycosylation modification, clustered in the mucin-like domain of GP1, full-length GP (GP1,2), and shed GP. In addition to the canonical role of the spike protein, GP1,2, in viral entry, ebolavirus GPs appear to have multiple additional functions, likely contributing to the complex pathogenesis of the virus. Here, we review the roles of ebolavirus GPs in viral pathogenesis.
authors.affiliation: State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China.
authors.forename: Yun-Jia
authors.initials: YJ
authors.lastname: Ning
authors.affiliation: State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Deng
authors.affiliation: State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China.
authors.forename: Zhihong
authors.initials: Z
authors.lastname: Hu
authors.affiliation: State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China. h.wang@wh.iov.cn.
authors.forename: Hualin
authors.initials: H
authors.lastname: Wang
mesh_terms: D000818:Animals; D029043:Ebolavirus / Q000502:physiology*; D006023:Glycoproteins / Q000378:metabolism*; D019142:Hemorrhagic Fever, Ebola / Q000473:pathology* / Q000821:virology*; D054884:Host-Pathogen Interactions; D006801:Humans; D015678:Viral Structural Proteins / Q000378:metabolism*; D053586:Virus Internalization; D014779:Virus Replication
chemical_list: D006023:Glycoproteins; D015678:Viral Structural Proteins
keywords: cytotoxicity; ebolavirus; glycoprotein (GP); immune evasion; inflammation; mucin-like domain (MLD); pathogenesis