title: Bioactive 4-hydroxycinnamide and bioactivities of Polyalthia cerasoides.
abstract: Constituents fromPolyalthia cerasoides, stem bark methanol extract, were previously documented. This study reports the first isolation of bioactiveN-(4-hydroxy-β-phenethyl)-4-hydroxycinnamide (1) from ethyl acetate extract of the plant species including stigmasterol and a mixture of triterpenes from hexane and dichloromethane extracts. Trace essential elements were found in the hexane extract in ppm level. The plant extracts were evaluated for their antimicrobial and antioxidative activities. The dichloromethane extract displayed the highest activity againstCorynebacterium diphtheriaeNCTC 10356 with MIC of 32µg/mL, as well as, the highest SOD activity with an IC50of 4.51µg/mL.
authors.affiliation: Center for Innovation Development and Technology Transfer, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand; Department of Parasitology and Community Health, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand.
authors.forename: Lertyot
authors.initials: L
authors.lastname: Treeratanapiboon
authors.affiliation: Center of Data Mining and Biomedical Informatics, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand.
authors.forename: Apilak
authors.initials: A
authors.lastname: Worachartcheewan
authors.affiliation: Center of Data Mining and Biomedical Informatics, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand; Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand.
authors.forename: Thummaruk
authors.initials: T
authors.lastname: Suksrichavalit
authors.affiliation: Department of Parasitology and Community Health, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand.
authors.forename: Rachada
authors.initials: R
authors.lastname: Kiatfuengfoo
authors.affiliation: Department of Chemistry, Faculty of Science, Srinakharinwirot University, Bangkok 10110, Thailand.
authors.forename: Supaluk
authors.initials: S
authors.lastname: Prachayasittikul
authors.affiliation: Chulabhorn Research Institute and Chulabhorn Graduate Institute, Bangkok 10210, Thailand.
authors.forename: Somsak
authors.initials: S
authors.lastname: Ruchirawat
authors.affiliation: Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand.
authors.forename: Virapong
authors.initials: V
authors.lastname: Prachayasittikul
keywords: 4-hydroxycinnamide; Polyalthia cerasoides; antimicrobials; antioxidants; trace elements