title: Assessment of in vivo systemic toxicity and biodistribution of iron-doped silica nanoshells.
abstract: Silica nanoparticles are an emerging class of biomaterials which may be used as diagnostic and therapeutic tools for biomedical applications. In particular, hollow silica nanoshells are attractive due to their hollow core. Approximately 70% of a 500 nm nanoshell is hollow, therefore more particles can be administered on a mg/kg basis compared to solid nanoparticles. Additionally, their nanoporous shell permits influx/efflux of gases and small molecules. Since the size, shape, and composition of a nanoparticle can dramatically alter its toxicity and biodistribution, the toxicology of these nanomaterials was assessed. A single dose toxicity study was performed in vivo to assess the toxicity of 500 nm iron-doped silica nanoshells at clinically relevant doses of 10-20 mg/kg. This study showed that only a trace amount of silica was detected in the body 10 weeks post-administration. The hematology, biochemistry and pathological results show that the nanoshells exhibit no acute or chronic toxicity in mice.
authors.affiliation: Department of Materials Science and Engineering, Nanoengineering, and Chemical Engineering, University of California, San Diego, CA, USA.
authors.forename: Natalie
authors.initials: N
authors.lastname: Mendez
authors.affiliation: Department of Materials Science and Engineering, Nanoengineering, and Chemical Engineering, University of California, San Diego, CA, USA.
authors.forename: Alexander
authors.initials: A
authors.lastname: Liberman
authors.affiliation: Department of Radiology, University of California, San Diego, CA, USA.
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Corbeil
authors.affiliation: Department of Radiology, University of California, San Diego, CA, USA.
authors.forename: Christopher
authors.initials: C
authors.lastname: Barback
authors.affiliation: Department of Materials Science and Engineering, Nanoengineering, and Chemical Engineering, University of California, San Diego, CA, USA.
authors.forename: Robert
authors.initials: R
authors.lastname: Viveros
authors.affiliation: Department of Materials Science and Engineering, Nanoengineering, and Chemical Engineering, University of California, San Diego, CA, USA.
authors.forename: James
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Pathology, University of California, San Diego, CA, USA.
authors.forename: Jessica
authors.initials: J
authors.lastname: Wang-Rodriguez
authors.affiliation: Department of Surgery, University of California, San Diego, CA, USA.
authors.forename: Sarah L
authors.initials: SL
authors.lastname: Blair
authors.affiliation: Department of Radiology, University of California, San Diego, CA, USA.
authors.forename: Robert
authors.initials: R
authors.lastname: Mattrey
authors.affiliation: Department of Radiology, University of California, San Diego, CA, USA.
authors.forename: David
authors.initials: D
authors.lastname: Vera
authors.affiliation: Department of Chemistry and Biochemistry, University of California, San Diego, CA, USA.
authors.forename: William
authors.initials: W
authors.lastname: Trogler
authors.affiliation: Department of Chemistry and Biochemistry, University of California, San Diego, CA, USA. Electronic address: akummel@ucsd.edu.
authors.forename: Andrew C
authors.initials: AC
authors.lastname: Kummel
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics / Q000633:toxicity; D005260:Female; D007501:Iron / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics* / Q000633:toxicity*; D051379:Mice; D057145:Nanoshells / Q000008:administration & dosage / Q000032:analysis* / Q000633:toxicity* / Q000648:ultrastructure; D010316:Particle Size; D012822:Silicon Dioxide / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics* / Q000633:toxicity*; D014018:Tissue Distribution
chemical_list: D001672:Biocompatible Materials; D012822:Silicon Dioxide; D007501:Iron
keywords: Biodistribution; Biomaterials; Nanomaterials; Silica nanoparticles; Toxicity; Toxicology