title: Cognitive Deficits Associated with Sleep Apnea in Myotonic Dystrophy Type 1.
abstract: Although sleep-disordered breathing and cognitive impairment are common features of patients with myotonic dystrophy type 1 (DM1), little is known about their relationship. Forty-three adult DM1 patients underwent 2 sequential polysomnographic sessions and a neuropsychological test battery (intellectual functioning, attention, language, memory, and executive functions). Lower scores in attention, vigilance, and executive functioning tests were associated with higher number of apneic/hypopneic episodes per hour of sleep and longer total sleep time at an oxyhemoglobin saturation of less than 90%. Results suggest a potential role for nighttime breathing problems in the cognitive impairment often observed in DM1 patients.
authors.affiliation: Groupe de Recherche Interdisciplinaire sur les Maladies Neuromusculaires (GRIMN), Jonquière, QC, Canada.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Gallais
authors.affiliation: Groupe de Recherche Interdisciplinaire sur les Maladies Neuromusculaires (GRIMN), Jonquière, QC, Canada.
authors.forename: Cynthia
authors.initials: C
authors.lastname: Gagnon
authors.affiliation: Groupe de Recherche Interdisciplinaire sur les Maladies Neuromusculaires (GRIMN), Jonquière, QC, Canada.
authors.forename: Jean
authors.initials: J
authors.lastname: Mathieu
authors.affiliation: Département des Sciences de la Santé, Université du Québec à Chicoutimi, Chicoutimi, QC, Canada.
authors.forename: Louis
authors.initials: L
authors.lastname: Richer
authors.affiliation: Groupe de Recherche Interdisciplinaire sur les Maladies Neuromusculaires (GRIMN), Jonquière, QC, Canada.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Jean
authors.affiliation: Groupe de Recherche Interdisciplinaire sur les Maladies Neuromusculaires (GRIMN), Jonquière, QC, Canada.
authors.forename: Luc
authors.initials: L
authors.lastname: Laberge