title: Drug Metabolism, Drug Interactions, and Drug-Induced Liver Injury in Living Donor Liver Transplant Patients.
abstract: Living donor liver transplant (LDLT) fills a critically needed gap in the number of livers available for transplant. However, little is known about the functional recovery of the liver in the donor and in the recipient after surgery. Given that both donor and recipients are treated with several drugs, it is important to characterize the time course of recovery of hepatic synthetic, metabolic, and excretory function in these patients. In the absence of data from LDLT, information on the effect of liver disease on the pharmacokinetics of medications can be used as guidance for drug dosing in LDLT patients.
authors.affiliation: Thomas Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA. Electronic address: ganesx@upmc.edu.
authors.forename: Swaytha
authors.initials: S
authors.lastname: Ganesh
authors.affiliation: Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, 731 Salk Hall, 3501 Terrace Street, Pittsburgh, PA 15261, USA.
authors.forename: Omar Abdulhameed
authors.initials: OA
authors.lastname: Almazroo
authors.affiliation: Thomas Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA.
authors.forename: Amit
authors.initials: A
authors.lastname: Tevar
authors.affiliation: Thomas Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA. Electronic address: humara2@upmc.edu.
authors.forename: Abhinav
authors.initials: A
authors.lastname: Humar
authors.affiliation: Thomas Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA; Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, 718 Salk Hall, 3501 Terrace Street, Pittsburgh, PA 15261, USA; Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
authors.forename: Raman
authors.initials: R
authors.lastname: Venkataramanan
mesh_terms: D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000401:mortality / Q000503:physiopathology; D004347:Drug Interactions; D005260:Female; D006084:Graft Rejection; D006085:Graft Survival; D006801:Humans; D008099:Liver / Q000187:drug effects*; D016031:Liver Transplantation; D019520:Living Donors; D008297:Male; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D011379:Prognosis; D015996:Survival Rate; D066027:Transplant Recipients
chemical_list: D004364:Pharmaceutical Preparations
keywords: Cytochrome P450; Drug metabolism; Hepatic regeneration; Hepatotoxicity; Living donor liver transplantation; Pharmacokinetics