title: New antimicrobial anthraquinone 6,61-bis (1,5,7-trihydroxy-3-hydroxymethylanthraquinone) isolated fromStreptomycessp. isolate ERI-26.
abstract: The present report is aboutStreptomycessp. isolate ERI-26 isolated from the soil sample of Nilgiri forest, Western Ghats. The methanol extract of ERI-26 showed good antimicrobial activity against tested microbes. The antimicrobial novel anthraquinones were purified by bioactivity-guided fractionation using a silica gel column and preparative HPLC. The compound was characterized and identified by UV, IR, NMR and MASS spectral data. The compound named as 6,61-bis (1,5,7-trihydroxy-3-hydroxymethylanthraquinone), showed significant antimicrobial activities against tested microbes. The isolated compound inhibited the tested bacterial growth,Staphylococcus aureusat 62.5 μg/ml,Staphylococcus epidermidisat 15.62 μg/m,Bacillus subtilisat 62.5 μg/ml, fungi;Trichophyton mentagrophytesat 15.62 μg/mTrichophyton simiiat 15.62 μg/ml,Aspergillus nigerat. 7.81 μg/ml,Aspergiller flavusat 3.90 μg/ml,Trichophyton rubrum296 at 62.5 μg/ml,T. rubrum57/01 at 7.81 μg/ml,Magnaporthe griseaat 15.62 μg/ml. andBotrytis cinereaat 3.90 μg/ml. Isolated anthraquinone compound and its antimicrobial activity were newly reported.
authors.affiliation: Department of Botany and Microbiology, Addiriyah Chair for Environmental Studies, College of Science, King Saud University, P.O. Box. 24551, Riyadh 11451, Saudi Arabia; Division of Microbiology, Entomology Research Institute, Loyola College, Chennai 600034, India.
authors.forename: V
authors.initials: V
authors.lastname: Duraipandiyan
authors.affiliation: Department of Botany and Microbiology, Addiriyah Chair for Environmental Studies, College of Science, King Saud University, P.O. Box. 24551, Riyadh 11451, Saudi Arabia.
authors.forename: Naif Abdullah
authors.initials: NA
authors.lastname: Al-Dhabi
authors.affiliation: Division of Microbiology, Entomology Research Institute, Loyola College, Chennai 600034, India; Visiting Professor Programme, Deanship of Scientific Research, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.
authors.forename: S
authors.initials: S
authors.lastname: Ignacimuthu
keywords: 16s rRNA; Anthraquinones; Antimicrobial; HPLC; NMR; Streptomyces sp.