title: Biosynthetic approaches to creating bioactive fungal metabolites: Pathway engineering and activation of secondary metabolism.
abstract: The diversity of natural products is greater than that of combinatorial chemistry compounds and is similar to that of drugs. Compounds rich in sp3carbons, such as natural products, typically exhibit high structural complexity and high specificity to molecular targets. Microorganisms can synthesize such sp3carbon-rich compounds and can be used as excellent factories for making bioactive compounds. Here, we mainly focus on pathway engineering of two sp3carbon-rich bioactive indole alkaloids, fumitremorgin C and terpendole E. We also demonstrate the importance of activation of secondary metabolism by focusing on tenuazonic acid, a bioactive tetramic acid compound, as an example.
authors.affiliation: RIKEN CSRS, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Motoyama
authors.affiliation: RIKEN CSRS, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan. Electronic address: hisyo@riken.jp.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Osada
mesh_terms: D001688:Biological Products / Q000737:chemistry / Q000378:metabolism*; D004224:Diterpenes / Q000737:chemistry / Q000378:metabolism*; D005658:Fungi / Q000378:metabolism*; D026121:Indole Alkaloids / Q000737:chemistry / Q000378:metabolism*; D007211:Indoles / Q000737:chemistry / Q000378:metabolism*; D015394:Molecular Structure; D064210:Secondary Metabolism; D013720:Tenuazonic Acid / Q000737:chemistry / Q000378:metabolism*
chemical_list: D001688:Biological Products; D004224:Diterpenes; D026121:Indole Alkaloids; D007211:Indoles; C477863:terpendole E; D013720:Tenuazonic Acid; C010522:tryptoquivaline
keywords: Fumitremorgin C; Indole-diterpene; Mycotoxin; Nonribosomal peptide; Pathway engineering; Terpendole E