title: Primary Breast Lymphoma: Analysis of 55 Cases of the Spanish Lymphoma Oncology Group.
abstract: Primary breast lymphoma is a rare form of localized extranodal lymphoma, which affects the mammary glands unilaterally or bilaterally, and can also affect the regional lymph nodes.
  
  
  
  We reviewed 55 patients, with disease stages IE and IIE, diagnosed in 16 Spanish institutions between 1989 and 2016. A serial of clinical variables and treatment were collected, and overall survival (OS) and progression-free survival (PFS) were calculated.
  
  
  
  Of the 55 patients, 96.4% were women with an average age of 69 years. A total of 53 patients corresponded to non-Hodgkin lymphoma (NHL), of whom 36.3% had lymph node involvement upon diagnosis. Of the patients, 58.2% were stage IE, and 41.8% were stage IIE. Treatments received included radiotherapy (36.3%), chemotherapy (85.5%), and rituximab (in 38 of the 45 patients with NHL treated with chemotherapy). In all, 82.2% of complete responses were achieved. OS and progression-free survival at 5 years in NHL patients was 76% and 73%, respectively.
  
  
  
  Current treatments (chemotherapy, immunotherapy, and radiotherapy) achieve good control of the disease, with an OS of 5 years in 80% of the patients, although there is no consensus in treatment, given the scarce incidence of these lymphomas.
authors.affiliation: Department of Medical Oncology, Hospital Universitario Puerta de Hierro, Majadahonda, Spain. Electronic address: f3franc@gmail.com.
authors.forename: Fernando
authors.initials: F
authors.lastname: Franco Pérez
authors.affiliation: Department of Medical Oncology, Instituto Valenciano de Oncología, Valencia, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Lavernia
authors.affiliation: Department of Medical Oncology, Hospital Universitario de Gran Canaria Doctor Negrín, Las Palmas de Gran Canarias, Spain.
authors.forename: David
authors.initials: D
authors.lastname: Aguiar-Bujanda
authors.affiliation: Department of Medical Oncology, Hospital Serranía de Ronda, Málaga, Spain.
authors.forename: José
authors.initials: J
authors.lastname: Miramón
authors.affiliation: Department of Medical Oncology, Hospital Universitari Sant Joan de Reus, Reus, Spain.
authors.forename: Josep
authors.initials: J
authors.lastname: Gumá
authors.affiliation: Department of Medical Oncology, Hospital Universitario Virgen de la Salud, Toledo, Spain.
authors.forename: Rut
authors.initials: R
authors.lastname: Álvarez
authors.affiliation: Department of Medical Oncology, Hospital Universitari i Politècnic La Fe, Valencia, Spain.
authors.forename: José
authors.initials: J
authors.lastname: Gómez-Codina
authors.affiliation: Department of Medical Oncology, Complejo Hospitalario de Pontevedra, Pontevedra, Spain.
authors.forename: Francisco García
authors.initials: FG
authors.lastname: Arroyo
authors.affiliation: Department of Medical Oncology, Hospital Universitario de Canarias, San Cristóbal de La Laguna, Spain.
authors.forename: Marta
authors.initials: M
authors.lastname: Llanos
authors.affiliation: Department of Medical Oncology, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain.
authors.forename: Miguel
authors.initials: M
authors.lastname: Marin
authors.affiliation: Department of Medical Oncology, Instituto Oncológico de Kutxa, Donistia, Spain.
authors.forename: Jesus
authors.initials: J
authors.lastname: Alfaro
authors.affiliation: Department of Medical Oncology, Hospital Universitario Virgen de la Victoria, Málaga, Spain.
authors.forename: Cristina
authors.initials: C
authors.lastname: Quero
authors.affiliation: Department of Medical Oncology, Hospital Universitario San Cecilio, Granada, Spain.
authors.forename: Mayte
authors.initials: M
authors.lastname: Delgado
authors.affiliation: Department of Medical Oncology, Hospital Universitario Virgen de la Macarena, Sevilla, Spain.
authors.forename: Esteban
authors.initials: E
authors.lastname: Nogales
authors.affiliation: Department of Medical Oncology, Hospital General Universitario de Elche, Alicante, Spain.
authors.forename: Francisco
authors.initials: F
authors.lastname: Menarguez
authors.affiliation: Department of Medical Oncology, Hospital General Universitario de Elche, Alicante, Spain.
authors.forename: Natividad
authors.initials: N
authors.lastname: Martinez
authors.affiliation: Department of Medical Oncology, Hospital Universitario Puerta de Hierro, Majadahonda, Spain.
authors.forename: Maria
authors.initials: M
authors.lastname: Torrente
authors.affiliation: Department of Biostatistics, Hospital Universitario Puerta de Hierro, Majadahonda, Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: Royuela
authors.affiliation: Department of Medical Oncology, Hospital Universitario Insular de Gran Canaria, Las Palmas de Gran Canarias, Spain.
authors.forename: Delvys
authors.initials: D
authors.lastname: Abreu
authors.affiliation: Department of Medical Oncology, Hospital Universitario Puerta de Hierro, Majadahonda, Spain.
authors.forename: Mariano
authors.initials: M
authors.lastname: Provencio
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D018567:Breast Neoplasms, Male / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008223:Lymphoma / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy / Q000401:mortality; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents
keywords: Chemotherapy; Extranodal lymphoma; Immunotherapy; Lumpectomy; Neoplasms of the breast