title: In utero exposure to LPS alters the postnatal acute-phase response in beef heifers.
abstract: The potential effect of prenatal LPS exposure on the postnatal acute phase response (APR) to an LPS challenge in heifers was determined. Pregnant crossbred cows were separated into prenatal immune stimulation (PIS) and saline groups (Control). From these treatments, heifer calves were identified at weaning to subsequently receive an exogenous LPS challenge. Sickness behavior scores (SBS) were recorded and blood samples were collected at 30-min intervals from -2 to 8 h and again at 24 h relative to the LPS challenge. There was a treatment × time interaction for the change in vaginal temperature (VT) such that the change in VT was greater in Control than PIS from 150 to 250 min, yet it was greater in PIS than Control from 355 to 440 min and from 570 to 1145 min. There was also a treatment × time interaction for SBS such that scores were greater in Control than PIS at 0.5 h, yet were greater in PIS than Control from 2.5 to 4 h post-LPS. There was a tendency for a treatment × time interaction for serum concentrations of IL-6, which were greater in PIS than Control heifers from 5.5 to 6 h and from 7 to 8 h post-challenge. Thus, a single exposure to LPS during gestation can alter the postnatal APR to LPS in heifer calves.
authors.affiliation: 1 USDA-ARS, Livestock Issues Research Unit, Lubbock, TX, USA.
authors.forename: Jeffery A
authors.initials: JA
authors.lastname: Carroll
authors.affiliation: 1 USDA-ARS, Livestock Issues Research Unit, Lubbock, TX, USA.
authors.forename: Nicole C
authors.initials: NC
authors.lastname: Burdick Sanchez
authors.affiliation: 2 University of Florida, Range Cattle Research and Education Center, Ona, FL, USA.
authors.forename: John D
authors.initials: JD
authors.lastname: Arthingon
authors.affiliation: 3 University of Florida, Department of Animal Sciences, Gainesville, FL, USA.
authors.forename: Corwin D
authors.initials: CD
authors.lastname: Nelson
authors.affiliation: 4 University of Florida, Range Cattle Research and Education Center, Ona, FL, USA.
authors.forename: Aimee L
authors.initials: AL
authors.lastname: Benjamin
authors.affiliation: 4 University of Florida, Range Cattle Research and Education Center, Ona, FL, USA.
authors.forename: Filiz T
authors.initials: FT
authors.lastname: Korkmaz
authors.affiliation: 4 University of Florida, Range Cattle Research and Education Center, Ona, FL, USA.
authors.forename: David E
authors.initials: DE
authors.lastname: Kerr
authors.affiliation: 2 University of Florida, Range Cattle Research and Education Center, Ona, FL, USA.
authors.forename: Phillip A
authors.initials: PA
authors.lastname: Lancaster
mesh_terms: D000210:Acute-Phase Reaction / Q000276:immunology / Q000662:veterinary*; D000818:Animals; D001947:Breeding; D002417:Cattle; D005260:Female; D005333:Fetus / Q000276:immunology*; D007109:Immunity; D015850:Interleukin-6 / Q000097:blood; D008070:Lipopolysaccharides / Q000276:immunology*; D009504:Neutrophils / Q000276:immunology; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000276:immunology / Q000662:veterinary*; D014599:Uterus / Q000276:immunology*; D014886:Weaning
chemical_list: D015850:Interleukin-6; D008070:Lipopolysaccharides
keywords: Acute phase response; cattle; lipopolysaccharide; neutrophils; prenatal stress