title: Perforating the nuclear boundary - how nuclear pore complexes assemble.
abstract: The nucleus is enclosed by the nuclear envelope, a double membrane which creates a selective barrier between the cytoplasm and the nuclear interior. Its barrier and transport characteristics are determined by nuclear pore complexes (NPCs) that are embedded within the nuclear envelope, and control molecular exchange between the cytoplasm and nucleoplasm. In this Commentary, we discuss the biogenesis of these huge protein assemblies from approximately one thousand individual proteins. We will summarize current knowledge about distinct assembly modes in animal cells that are characteristic for different cell cycle phases and their regulation.
authors.affiliation: Friedrich Miescher Laboratory of the Max Planck Society, Spemannstraße 39, Tübingen 72076, Germany.
authors.forename: Marion
authors.initials: M
authors.lastname: Weberruss
authors.affiliation: Friedrich Miescher Laboratory of the Max Planck Society, Spemannstraße 39, Tübingen 72076, Germany wolfram.antonin@tuebingen.mpg.de.
authors.forename: Wolfram
authors.identifier: 0000-0003-4669-379X
authors.initials: W
authors.lastname: Antonin
mesh_terms: D000818:Animals; D006801:Humans; D008954:Models, Biological; D022022:Nuclear Pore / Q000378:metabolism*; D028861:Nuclear Pore Complex Proteins / Q000378:metabolism*; D021381:Protein Transport
chemical_list: D028861:Nuclear Pore Complex Proteins
keywords: Annulate lamellae; Nuclear envelope; Nuclear pore complex; Nuclear transport