title: Roles of Notch Signaling in Adipocyte Progenitor Cells and Mature Adipocytes.
abstract: Adipose tissues, composed with mature adipocytes and preadipocytic stromal/stem cells, play crucial roles in whole body energy metabolism and regenerative medicine. Mature adipocytes are derived and differentiated from mesenchymal stem cells (MSCs) or preadipocytes. This differentiation process, also called adipogenesis, is regulated by several signaling pathways and transcription factors. Notch1 signaling is a highly conserved pathway that is indispensable for stem cell hemostasis and tissue development. In adipocyte progenitor cells, Notch1 signaling regulates the adipogenesis process including proliferation and differentiation of the adipocyte progenitor cells in vitro. Notably, the roles of Notch1 signaling in beige adipocytes formation, adipose development, and function, and the whole body energy metabolism have been recently reported. Here, we mainly review and discuss the roles of Notch1 signaling in adipogenesis in vitro as well as in beige adipocytes formation, adipocytes dedifferentiation, and function in vivo. J. Cell. Physiol. 232: 1258-1261, 2017. © 2016 Wiley Periodicals, Inc.
authors.affiliation: The Key Laboratory of Molecular Animal Nutrition, Ministry of Education, Zhejiang Provincial Laboratory of Feed and Animal Nutrition, College of Animal Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, P. R. China.
authors.forename: Tizhong
authors.initials: T
authors.lastname: Shan
authors.affiliation: The Key Laboratory of Molecular Animal Nutrition, Ministry of Education, Zhejiang Provincial Laboratory of Feed and Animal Nutrition, College of Animal Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, P. R. China.
authors.forename: Jiaqi
authors.initials: J
authors.lastname: Liu
authors.affiliation: The Key Laboratory of Molecular Animal Nutrition, Ministry of Education, Zhejiang Provincial Laboratory of Feed and Animal Nutrition, College of Animal Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, P. R. China.
authors.forename: Weiche
authors.initials: W
authors.lastname: Wu
authors.affiliation: The Key Laboratory of Molecular Animal Nutrition, Ministry of Education, Zhejiang Provincial Laboratory of Feed and Animal Nutrition, College of Animal Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, P. R. China.
authors.forename: Ziye
authors.initials: Z
authors.lastname: Xu
authors.affiliation: The Key Laboratory of Molecular Animal Nutrition, Ministry of Education, Zhejiang Provincial Laboratory of Feed and Animal Nutrition, College of Animal Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, P. R. China.
authors.forename: Yizhen
authors.initials: Y
authors.lastname: Wang
mesh_terms: D017667:Adipocytes / Q000166:cytology*; D000818:Animals; D002454:Cell Differentiation; D006801:Humans; D008954:Models, Biological; D051880:Receptors, Notch / Q000378:metabolism*; D015398:Signal Transduction; D013234:Stem Cells / Q000378:metabolism*
chemical_list: D051880:Receptors, Notch