title: The Crosstalk between Myeloid Derived Suppressor Cells and Immune Cells: To Establish Immune Tolerance in Transplantation.
abstract: Myeloid derived suppressor cells (MDSCs) are a heterogeneous population of myeloid precursor and progenitor cells and endowed with a robust immunosuppressive activity in multiple pathophysiological conditions. Recent studies have uncovered the crosstalk between MDSCs and immune cells (i.e., natural killer cells, dendritic cells, macrophages, natural killer T cells, and regulatory T cells) and its role in the establishment and maintenance of immune tolerant microenvironment in transplantation. Considering their strong immunosuppressive capability, MDSCs could become a prospective clinical regimen during transplantation tolerance induction, resulting in long-term graft survival with decreased or without immunosuppressive drugs. The review summarized recent research advances in this field and looked ahead at the research directions in the future.
authors.affiliation: Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China; Shanghai Key Laboratory of Organ Transplantation, Shanghai, China.
authors.forename: Chao
authors.identifier: 0000-0001-9672-0720
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China; Shanghai Key Laboratory of Organ Transplantation, Shanghai, China.
authors.forename: Shuo
authors.initials: S
authors.lastname: Wang
authors.affiliation: Shanghai Key Laboratory of Organ Transplantation, Shanghai, China; Department of Plastic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Yang
authors.affiliation: Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China; Shanghai Key Laboratory of Organ Transplantation, Shanghai, China; Department of Transfusion, Zhongshan Hospital, Fudan University, Shanghai, China.
authors.forename: Ruiming
authors.identifier: 0000-0003-0537-7045
authors.initials: R
authors.lastname: Rong
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D003713:Dendritic Cells / Q000276:immunology; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology; D008264:Macrophages / Q000276:immunology; D051379:Mice; D000072737:Myeloid-Derived Suppressor Cells / Q000276:immunology*; D055611:Natural Killer T-Cells / Q000276:immunology; D020239:Receptor Cross-Talk / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D023001:Transplantation Tolerance