title: Applicability of Isolates and Fractions of Plant Extracts in Murine Models in Type II Diabetes: A Systematic Review.
abstract: Type II diabetes mellitus is one of the most common public health problems worldwide. Its increasing prevalence in several countries and the difficult metabolic control of individuals with the disease justify studying strategies for primary prevention. The population has sought alternative and cheaper ways to treat the disease, including the use of plants considered medicinal by the population. In this study, we carried out a systematic review on the applicability of isolates and fractions of plant extracts in animal models in type II diabetes. A literature search was performed in MEDLINE/PubMed and Scopus databases. Studies using other experimental animals (horses, rabbits, and monkeys) and humans as well as articles in Chinese, German, and Russian were excluded. We assessed the quality of the studies included by using the criteria described in the ARRIVE guidelines. In general, the animals that received fractions or isolates presented reduced blood glucose levels, normalization of body weight and plasma insulin levels, and reduced total triglycerides and cholesterol. In addition, we observed wide variation among the analyzed parameters, which hindered comparison between the studies found. In further studies, standardized reports and experimental design would help to establish comparable study groups and advance the overall knowledge, thus facilitating translatability from animal data to human clinical conditions.
authors.affiliation: Department of Medicine and Nursing, Federal University of Viçosa, Viçosa, MG, Brazil.
authors.forename: Gabriela Diniz Pinto
authors.identifier: 0000-0002-0044-3579
authors.initials: GD
authors.lastname: Coelho
authors.affiliation: Department of Medicine and Nursing, Federal University of Viçosa, Viçosa, MG, Brazil.
authors.forename: Vanessa Soares
authors.initials: VS
authors.lastname: Martins
authors.affiliation: Department of Medicine and Nursing, Federal University of Viçosa, Viçosa, MG, Brazil.
authors.forename: Laura Vieira
authors.initials: LV
authors.lastname: do Amaral
authors.affiliation: Institute of Biomedical Science, Department of Structural Biology, Federal University of Alfenas, Alfenas, MG, Brazil.
authors.forename: Rômulo Dias
authors.initials: RD
authors.lastname: Novaes
authors.affiliation: Department of General Biology, Federal University of Viçosa, Viçosa, MG, Brazil.
authors.forename: Mariáurea Matias
authors.identifier: 0000-0003-1313-7877
authors.initials: MM
authors.lastname: Sarandy
authors.affiliation: Department of Animal Biology, Federal University of Viçosa, MG, Brazil.
authors.forename: Reggiani Vilela
authors.identifier: 0000-0002-5831-3590
authors.initials: RV
authors.lastname: Gonçalves