title: Computational properties of mitochondria in T cell activation and fate.
abstract: In this article, we review how mitochondrial Ca2+transport (mitochondrial Ca2+uptake and Na+/Ca2+exchange) is involved in T cell biology, including activation and differentiation through shaping cellular Ca2+signals. Based on recent observations, we propose that the Ca2+crosstalk between mitochondria, endoplasmic reticulum and cytoplasm may form a proportional-integral-derivative (PID) controller. This PID mechanism (which is well known in engineering) could be responsible for computing cellular decisions. In addition, we point out the importance of analogue and digital signal processing in T cell life and implication of mitochondrial Ca2+transport in this process.
authors.affiliation: Department of Biochemistry and Cancer Biology, School of Medicine, Meharry Medical College, Nashville, TN, USA.
authors.forename: Roman
authors.identifier: 0000-0002-5566-0810
authors.initials: R
authors.lastname: Uzhachenko
authors.affiliation: Department of Biochemistry and Cancer Biology, School of Medicine, Meharry Medical College, Nashville, TN, USA ashanker@mmc.edu.|Host-Tumor Interactions Research Program, Vanderbilt-Ingram Cancer Center, and the Center for Immunobiology, Vanderbilt University, Nashville, TN, USA.
authors.forename: Anil
authors.identifier: 0000-0001-6372-3669
authors.initials: A
authors.lastname: Shanker
authors.affiliation: Unité de Chronobiologie Théorique, Université Libre de Bruxelles, CP231, Boulevard du Triomphe, 1050 Brussels, Belgium gdupont@ulb.ac.be.
authors.forename: Geneviève
authors.initials: G
authors.lastname: Dupont
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D003593:Cytoplasm / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000378:metabolism; D006801:Humans; D008213:Lymphocyte Activation; D008928:Mitochondria / Q000378:metabolism*; D012964:Sodium / Q000378:metabolism; D013601:T-Lymphocytes / Q000378:metabolism / Q000473:pathology*
chemical_list: D012964:Sodium; D002118:Calcium
keywords: Ca2+ signalling; PID controller; T lymphocytes; digital and analogue signals; mitochondria; systems biology