title: Evaluation of a new modified QuEChERS method for the monitoring of carbamate residues in high-fat cheeses by using UHPLC-MS/MS.
abstract: A simple and efficient method for the determination of 28 carbamates in high-fat cheeses is proposed. The methodology is based on a modified quick, easy, cheap, effective, rugged, and safe procedure as sample treatment using a new sorbent (Z-Sep+) followed by ultra-high performance liquid chromatography with tandem mass spectrometry determination. The method has been validated in different kinds of cheese (Gorgonzola, Roquefort, and Camembert), achieving recoveries of 70-115%, relative standard deviations lower than 13% and limits of quantification lower than 5.4 μg/kg, below the maximum residue levels tolerated for these compounds by the European legislation. The matrix effect was lower than ±30% for all the studied pesticides. The combination of ultra-high performance liquid chromatography and tandem mass spectrometry with this modified quick, easy, cheap, effective, rugged, and safe procedure using Z-Sep+allowed a high sample throughput and an efficient cleaning of extracts for the control of these residues in cheeses with a high fat content.
authors.affiliation: Department of Analytical Chemistry, Faculty of Sciences, University of Granada, Granada, Spain.|Department of Dairy Science, Faculty of Agriculture, Cairo University, Giza, Egypt.
authors.forename: Ahmed M
authors.initials: AM
authors.lastname: Hamed
authors.affiliation: Department of Analytical Chemistry, Faculty of Sciences, University of Granada, Granada, Spain.|Department of Physical and Analytical Chemistry, University of Jaén, Jaén, Spain.
authors.forename: David
authors.initials: D
authors.lastname: Moreno-González
authors.affiliation: Department of Analytical Chemistry, Faculty of Sciences, University of Granada, Granada, Spain.
authors.forename: Laura
authors.initials: L
authors.lastname: Gámiz-Gracia
authors.affiliation: Department of Analytical Chemistry, Faculty of Sciences, University of Granada, Granada, Spain.
authors.forename: Ana M
authors.initials: AM
authors.lastname: García-Campaña
mesh_terms: D002219:Carbamates / Q000032:analysis*; D002611:Cheese / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid; D005504:Food Analysis / Q000191:economics / Q000379:methods*; D010573:Pesticide Residues / Q000032:analysis*; D053719:Tandem Mass Spectrometry
chemical_list: D002219:Carbamates; D010573:Pesticide Residues
keywords: carbamates; cheese; dispersive solid-phase extraction; tandem mass spectrometry; ultra-high performance liquid chromatography