title: Functional imaging of the human brain using a modular, fibre-less, high-density diffuse optical tomography system.
abstract: We present the first three-dimensional, functional images of the human brain to be obtained using a fibre-less, high-density diffuse optical tomography system. Our technology consists of independent, miniaturized, silicone-encapsulated DOT modules that can be placed directly on the scalp. Four of these modules were arranged to provide up to 128, dual-wavelength measurement channels over a scalp area of approximately 60 × 65 mm2. Using a series of motor-cortex stimulation experiments, we demonstrate that this system can obtain high-quality, continuous-wave measurements at source-detector separations ranging from 14 to 55 mm in adults, in the presence of hair. We identify robust haemodynamic response functions in 5 out of 5 subjects, and present diffuse optical tomography images that depict functional haemodynamic responses that are well-localized in all three dimensions at both the individual and group levels. This prototype modular system paves the way for a new generation of wearable, wireless, high-density optical neuroimaging technologies.
authors.affiliation: Biomedical Optics Research Laboratory, Department of Medical Physics and Biomedical Engineering, University College London, London, WC1E 6BT, UK.
authors.forename: Danial
authors.initials: D
authors.lastname: Chitnis
authors.affiliation: Biomedical Optics Research Laboratory, Department of Medical Physics and Biomedical Engineering, University College London, London, WC1E 6BT, UK.
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Cooper
authors.affiliation: Biomedical Optics Research Laboratory, Department of Medical Physics and Biomedical Engineering, University College London, London, WC1E 6BT, UK.
authors.forename: Laura
authors.initials: L
authors.lastname: Dempsey
authors.affiliation: Biomedical Optics Research Laboratory, Department of Medical Physics and Biomedical Engineering, University College London, London, WC1E 6BT, UK.
authors.forename: Samuel
authors.initials: S
authors.lastname: Powell
authors.affiliation: Biomedical Optics Research Laboratory, Department of Medical Physics and Biomedical Engineering, University College London, London, WC1E 6BT, UK.
authors.forename: Simone
authors.initials: S
authors.lastname: Quaggia
authors.affiliation: Biomedical Optics Research Laboratory, Department of Medical Physics and Biomedical Engineering, University College London, London, WC1E 6BT, UK.
authors.forename: David
authors.initials: D
authors.lastname: Highton
authors.affiliation: Biomedical Optics Research Laboratory, Department of Medical Physics and Biomedical Engineering, University College London, London, WC1E 6BT, UK.
authors.forename: Clare
authors.initials: C
authors.lastname: Elwell
authors.affiliation: Biomedical Optics Research Laboratory, Department of Medical Physics and Biomedical Engineering, University College London, London, WC1E 6BT, UK.
authors.forename: Jeremy C
authors.initials: JC
authors.lastname: Hebden
authors.affiliation: Biomedical Optics Research Laboratory, Department of Medical Physics and Biomedical Engineering, University College London, London, WC1E 6BT, UK.
authors.forename: Nicholas L
authors.initials: NL
authors.lastname: Everdell
keywords: (170.0110) Imaging systems; (170.6960) Tomography; (230.0250) Optoelectronics