title: Mitochondrial Dynamics as a Therapeutic Target for Treating Cardiac Diseases.
abstract: Mitochondria are dynamic in nature and are able to shift their morphology between elongated interconnected mitochondrial networks and a fragmented disconnected arrangement by the processes of mitochondrial fusion and fission, respectively. Changes in mitochondrial morphology are regulated by the mitochondrial fusion proteins - mitofusins 1 and 2 (Mfn1 and 2), and optic atrophy 1 (Opa1) as well as the mitochondrial fission proteins - dynamin-related peptide 1 (Drp1) and fission protein 1 (Fis1). Despite having a unique spatial arrangement, cardiac mitochondria have been implicated in a variety of disorders including ischemia-reperfusion injury (IRI), heart failure, diabetes, and pulmonary hypertension. In this chapter, we review the influence of mitochondrial dynamics in these cardiac disorders as well as their potential as therapeutic targets in tackling cardiovascular disease.
authors.affiliation: Cardiovascular and Metabolic Disorders (CVMD) Program, Duke-NUS Medical School, 8 College Road, Singapore, 169857, Singapore. ongsangbing@duke-nus.edu.sg.|National Heart Research Institute Singapore, National Heart Centre Singapore, 5 Hospital Drive, Singapore, 169609, Singapore. ongsangbing@duke-nus.edu.sg.
authors.forename: Sang-Bing
authors.initials: SB
authors.lastname: Ong
authors.affiliation: Cardiovascular and Metabolic Disorders (CVMD) Program, Duke-NUS Medical School, 8 College Road, Singapore, 169857, Singapore.|National Heart Research Institute Singapore, National Heart Centre Singapore, 5 Hospital Drive, Singapore, 169609, Singapore.|The Hatter Cardiovascular Institute, University College London Hospitals and Medical School, London, UK.
authors.forename: Derek J
authors.initials: DJ
authors.lastname: Hausenloy
mesh_terms: D000818:Animals; D017209:Apoptosis; D003920:Diabetes Mellitus / Q000188:drug therapy / Q000503:physiopathology; D006331:Heart Diseases / Q000188:drug therapy* / Q000503:physiopathology; D006333:Heart Failure / Q000188:drug therapy / Q000503:physiopathology; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy / Q000503:physiopathology; D008929:Mitochondria, Heart / Q000502:physiology; D063154:Mitochondrial Dynamics / Q000187:drug effects* / Q000502:physiology; D015428:Myocardial Reperfusion Injury / Q000188:drug therapy / Q000503:physiopathology
keywords: Cardiac diseases; Cardiac disorders; Drp1; Mfn1; Mfn2; Mitochondrial dynamics; Mitochondrial morphology; Opa1