title: Apolipoprotein E Gene Variants and Risk of Coronary Heart Disease: A Meta-Analysis.
abstract: Objectives.Apo Egenes involved in lipoprotein synthesis and metabolism are considered one of the candidates to CHD. However, the results remain conflicting.Methods. We performed this meta-analysis based on 30 published studies including 11,804 CHD patients and 17,713 controls.Results. Compared with the wild genotype E3/3, the variant genotypesApoEE3/4 and E4/4 were associated with 22% and 45% increased risk of CHD, respectively (E3/4 versus E3/3: OR = 1.22, 95% CI = 1.15-1.29; E4/4 versus E3/3: OR = 1.45, 95% CI = 1.23-1.71). Besides, compared withε3 allele, carriers with theε4 allele had a 46% increased risk of CHD (OR = 1.46, 95% CI = 1.28-1.66), while theε2 had no significantly decreased risk of CHD. In the subgroup analysis by ethnicity,ε4 had a 25% increased risk of CHD in Caucasians (OR = 1.25, 95% CI = 1.11-1.41), and the effects were more evident in Mongolians (OR = 2.29, 95% CI = 1.89-2.77). Theε2 allele had a decreased risk of CHD in Caucasians (OR = 0.84, 95% CI = 0.74-0.96), but not in Mongolians.Conclusions. The analysis suggested thatApoEε4 mutation was associated with the increased risk of CHD, whileApoEε2 allele had a decreased risk of CHD just in Caucasians.
authors.affiliation: Key Laboratory of Environmental Medicine Engineering, Ministry of Education, Department of Epidemiology and Biostatistics, School of Public Health, Southeast University, Nanjing, China.
authors.forename: Min
authors.identifier: 0000-0002-5265-3711
authors.initials: M
authors.lastname: Xu
authors.affiliation: Graduate School of Peking Union Medical College, Beijing, China; National Research Institute for Family Planning, Beijing, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Centers for Disease Control and Prevention, Zhejiang, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Graduate School of Peking Union Medical College, Beijing, China; National Research Institute for Family Planning, Beijing, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Ma
authors.affiliation: National Research Institute for Family Planning, Beijing, China.
authors.forename: Qiaoyun
authors.initials: Q
authors.lastname: Dai
authors.affiliation: Department of Cardiology, ZhongDa Hospital, Southeast University, Nanjing, Jiangsu, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Zhi
authors.affiliation: Key Laboratory of Environmental Medicine Engineering, Ministry of Education, Department of Epidemiology and Biostatistics, School of Public Health, Southeast University, Nanjing, China.
authors.forename: Bei
authors.initials: B
authors.lastname: Wang
authors.affiliation: Key Laboratory of Environmental Medicine Engineering, Ministry of Education, Department of Epidemiology and Biostatistics, School of Public Health, Southeast University, Nanjing, China.
authors.forename: Lina
authors.identifier: 0000-0003-3665-5706
authors.initials: L
authors.lastname: Wang
mesh_terms: D001057:Apolipoproteins E / Q000235:genetics*; D003324:Coronary Artery Disease / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics*; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000453:epidemiology* / Q000235:genetics*; D014644:Genetic Variation / Q000235:genetics; D006801:Humans; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D015995:Prevalence; D012307:Risk Factors
chemical_list: D001057:Apolipoproteins E; D005819:Genetic Markers