title: EFFECTS OF SELECTIVE CHOLINERGIC AND GABAERGIC LESIONS OF THE NUCLEUS BASALIS MAGNOCELLULARIS ON PLACE OR RESPONCE LEARNING IN PLUS-SHAPED MAZE.
abstract: In the present study we evaluated effects of selective cholinergic or GABAergic lesions of the nucleus basalis magnocellularis (NBM) using immunotxins 192 IgG-saporin and GAT1-SAP on place and response learning in plus-shaped maze. In current behavioral paradigm rats learned food-rewarded mazes that were efficiently learned using either place or turning strategies. A histological evaluation indicated that 192 IgG-saporin lesions specifically depleted cholinergic neurons but did not result in noticeable damage to the GABAergic cells within NBM. GAT1-SAP lesions resulted extensive damage of GABAergic and a mild reduction of cholinergic NBM neurons. The results of present behavioral experiments showed, that selective lesions of cholinergic or GABAergic neurons in the NBM impair, but do not abolish, the animal's ability to learn location of rewarded arm of maze (place learning) or a skilled motor behavior (response learning). Our findings suggest the role of NBM cholinergic and GABAergic cortical projection neurons in processing of cognitive information. We suggested that lesions of NBM projections to the cortex modulate learning-mediated plasticity and impair both place and response learning.
authors.affiliation: I. Beritashvili Center of Experimental Biomedicine, Tbilisi, Georgia.
authors.forename: L
authors.initials: L
authors.lastname: Kruashvili
authors.affiliation: I. Beritashvili Center of Experimental Biomedicine, Tbilisi, Georgia.
authors.forename: M
authors.initials: M
authors.lastname: Demurishvili
authors.affiliation: I. Beritashvili Center of Experimental Biomedicine, Tbilisi, Georgia.
authors.forename: M
authors.initials: M
authors.lastname: Burjanadze
authors.affiliation: I. Beritashvili Center of Experimental Biomedicine, Tbilisi, Georgia.
authors.forename: M
authors.initials: M
authors.lastname: Dashniani
authors.affiliation: I. Beritashvili Center of Experimental Biomedicine, Tbilisi, Georgia.
authors.forename: G
authors.initials: G
authors.lastname: Beselia
mesh_terms: D000818:Animals; D000906:Antibodies / Q000633:toxicity; D000911:Antibodies, Monoclonal / Q000633:toxicity; D020532:Basal Nucleus of Meynert / Q000502:physiology*; D059329:Cholinergic Neurons / Q000502:physiology*; D050485:GABA Plasma Membrane Transport Proteins / Q000276:immunology / Q000378:metabolism; D059330:GABAergic Neurons / Q000502:physiology*; D000922:Immunotoxins / Q000633:toxicity; D008297:Male; D018782:Maze Learning; D051381:Rats; D012201:Reward; D054789:Ribosome Inactivating Proteins, Type 1 / Q000633:toxicity; D000076985:Saporins; D065853:Spatial Learning
chemical_list: C085696:192 IgG-saporin; D000906:Antibodies; D000911:Antibodies, Monoclonal; D050485:GABA Plasma Membrane Transport Proteins; D000922:Immunotoxins; D054789:Ribosome Inactivating Proteins, Type 1; D000076985:Saporins