title: Diagnostic Value of 68Ga PSMA-11 PET/CT Imaging of Brain Tumors-Preliminary Analysis.
abstract: OBJECTIVE
  To evaluate the feasibility of using Ga PSMA-11 PET/CT for imaging brain lesions and its comparison with F-FDG.
  
  
  METHODS
  Ten patients with brain lesions were included in the study. Five patients were treated cases of glioblastoma with suspected recurrence. F-FDG and Ga PSMA-11 brain scans were done for these patients. Five patients were sent for assessing the nature (primary lesion/metastasis) of space occupying lesion in brain. They underwent whole body F-FDG PET/CT scan and a primary site elsewhere in the body was ruled out. Subsequently they underwent Ga PSMA-11 brain PET/CT imaging. Target to background ratios (TBR) for the brain lesions were calculated using contralateral cerebellar uptake as background.
  
  
  RESULTS
  In five treated cases of glioblastoma with suspected recurrence the findings of Ga PSMA-11 PET/CT showed good correlation with that of F-FDG PET/CT scan. Compared to the F-FDG, Ga PSMA-11 PET/CT showed better visualization of the recurrent lesion (presence/absence) owing to its significantly high TBR. Among the five cases evaluated for lesion characterization glioma and atypical meningioma patients showed higher SUVmax in the lesion with Ga PSMA-11 than with F-FDG and converse in cases of lymphoma. TBR was better with Ga PSMA PET/CT in all cases.
  
  
  CONCLUSIONS
  Ga PSMA-11 PET/CT brain imaging is a potentially useful imaging tool in the evaluation of brain lesions. Absence of physiological uptake of Ga PSMA-11 in the normal brain parenchyma results in high TBR values and consequently better visualization of metabolically active disease in brain.
authors.affiliation: From the *Department of Nuclear Medicine and PET/CT KIMS-DDNMRC, Trivandrum, Kerala; †Molecular Group of Companies, Puthuvype, Ernakulam, Kerala; ‡Department of Radiation Oncology, Regional Cancer Centre, Trivandrum, Kerala; §Department of Radiation Oncology, KIMS Cancer Centre, Trivandrum, Kerala; and ∥Department of Neurosurgery, Sree Chitra Tirunal Institute of Medical Sciences and Technology, Trivandrum, Kerala, India.
authors.forename: Arun
authors.initials: A
authors.lastname: Sasikumar
authors.forename: Ajith
authors.initials: A
authors.lastname: Joy
authors.forename: M R A
authors.initials: MR
authors.lastname: Pillai
authors.forename: Raviteja
authors.initials: R
authors.lastname: Nanabala
authors.forename: Muhammed
authors.initials: M
authors.lastname: Anees K
authors.forename: P G
authors.initials: PG
authors.lastname: Jayaprakash
authors.forename: Jayaprakash
authors.initials: J
authors.lastname: Madhavan
authors.forename: Suresh
authors.initials: S
authors.lastname: Nair
mesh_terms: D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000000981:diagnostic imaging*; D002648:Child; D004492:Edetic Acid / Q000031:analogs & derivatives; D005260:Female; D019788:Fluorodeoxyglucose F18; D005709:Gallium Isotopes; D005710:Gallium Radioisotopes; D005909:Glioblastoma / Q000000981:diagnostic imaging*; D005910:Glioma / Q000000981:diagnostic imaging; D006801:Humans; D008223:Lymphoma / Q000000981:diagnostic imaging*; D008297:Male; D008577:Meningeal Neoplasms / Q000000981:diagnostic imaging*; D008579:Meningioma / Q000000981:diagnostic imaging*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging*; D009842:Oligopeptides; D000072078:Positron Emission Tomography Computed Tomography; D019275:Radiopharmaceuticals; D051598:Whole Body Imaging; D055815:Young Adult
chemical_list: D005709:Gallium Isotopes; D005710:Gallium Radioisotopes; D009842:Oligopeptides; D019275:Radiopharmaceuticals; C000718244:gallium 68 PSMA-11; D019788:Fluorodeoxyglucose F18; D004492:Edetic Acid