title: Activity limitations in myasthenia gravis and relation to clinical variables.
abstract: It is unknown how fluctuations in muscle weakness affect activity limitations in myasthenia gravis patients and how the severity of these limitations compares with published data on other neuromuscular disorders (NMD).
  
  
  
  In this study we analyzed ACTIVLIM (acronym of "ACTIVity LIMitations") and quantitative myasthenia gravis (QMG) scores. We assessed the impact of QMG and other clinical variables on ACTIVLIM, using B coefficients.
  
  
  
  The mean ACTIVLIM score in 118 MG patients was 3.3. There was a correlation between QMG and ACTIVLIM (B coefficient = -0.206, P < 0.001) and between changes in both scores (B coefficient = -0.175, P = 0.002). Men and patients without another autoimmune disease had a better ACTIVLIM score (B coefficient = 0.785, P = 0.015 and B coefficient = 0.998, P = 0.008, respectively).
  
  
  
  The ACTIVLIM score in MG is higher than in other NMD. Fluctuations in QMG correlated significantly with changes in ACTIVLIM. Muscle Nerve 56: 64-70, 2017.
authors.affiliation: Department of Neurology, Leiden University Medical Center, J3-166, P.O. Box 9600, 2300, RC Leiden, The Netherlands.
authors.forename: Robert H P
authors.initials: RHP
authors.lastname: De Meel
authors.affiliation: Department of Neurology, Leiden University Medical Center, J3-166, P.O. Box 9600, 2300, RC Leiden, The Netherlands.
authors.forename: Alexander F
authors.initials: AF
authors.lastname: Lipka
authors.affiliation: Department of Neurology, Leiden University Medical Center, J3-166, P.O. Box 9600, 2300, RC Leiden, The Netherlands.
authors.forename: Marije
authors.initials: M
authors.lastname: Van Der Lende
authors.affiliation: Department of Biostatistics, Leiden University Medical Center, Leiden, The Netherlands.
authors.forename: Erik W
authors.initials: EW
authors.lastname: Van Zwet
authors.affiliation: Department of Neurology, Leiden University Medical Center, J3-166, P.O. Box 9600, 2300, RC Leiden, The Netherlands.
authors.forename: Martijn R
authors.initials: MR
authors.lastname: Tannemaat
authors.affiliation: Department of Neurology, Leiden University Medical Center, J3-166, P.O. Box 9600, 2300, RC Leiden, The Netherlands.
authors.forename: Jan J G M
authors.initials: JJGM
authors.lastname: Verschuuren
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D001323:Autoantibodies / Q000097:blood; D004185:Disability Evaluation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018908:Muscle Weakness / Q000175:diagnosis / Q000209:etiology*; D009157:Myasthenia Gravis / Q000097:blood / Q000150:complications* / Q000276:immunology; D020794:Receptor Protein-Tyrosine Kinases / Q000276:immunology; D011950:Receptors, Cholinergic / Q000276:immunology; D012189:Retrospective Studies; D013223:Statistics as Topic
chemical_list: D001323:Autoantibodies; D011950:Receptors, Cholinergic; D020794:Receptor Protein-Tyrosine Kinases