title: FPA-FTIR Microspectroscopy for Monitoring Chemotherapy Efficacy in Triple-Negative Breast Cancer.
abstract: Triple-negative breast cancer is the most aggressive breast cancer subtype with limited treatment options and a poor prognosis. Approximately 70% of triple-negative breast cancer patients fail to achieve a pathologic complete response (pCR) after chemotherapy due to the lack of targeted therapies for this subtype. We report here the development of a focal-plane-array Fourier transform infrared (FPA-FTIR) microspectroscopic technique combined with principal component analysis (PCA) for monitoring chemotherapy effects in triple-negative breast cancer patients. The PCA results obtained using the FPA-FTIR spectral data collected from the same patients before and after the chemotherapy revealed discriminatory features that were consistent with the pathologic and clinical responses to chemotherapy, indicating the potential of the technique as a monitoring tool for observing chemotherapy efficacy.
authors.affiliation: Laboratory of Molecular Biology, Centre for Innovative Research in Medical and Natural Sciences, Faculty of Medicine, University of Rzeszow, Warzywna 1a, 35-959 Rzeszow, Poland.|Department of Genetics, Chair of Molecular Medicine, Faculty of Medicine, University of Rzeszow, Kopisto 2a, 35-959 Rzeszow, Poland.
authors.forename: Izabela
authors.initials: I
authors.lastname: Zawlik
authors.affiliation: Laboratory of Molecular Biology, Centre for Innovative Research in Medical and Natural Sciences, Faculty of Medicine, University of Rzeszow, Warzywna 1a, 35-959 Rzeszow, Poland.|Department of Human Histology, Chair of Morphological Sciences, Faculty of Medicine, University of Rzeszow, Kopisto 2a, 35-959 Rzeszow, Poland.
authors.forename: Ewa
authors.initials: E
authors.lastname: Kaznowska
authors.affiliation: Centre for Innovation and Transfer of Natural Sciences and Engineering Knowledge, University of Rzeszow, Pigonia 1, 35-959 Rzeszow, Poland.
authors.forename: Jozef
authors.initials: J
authors.lastname: Cebulski
authors.affiliation: Institute of Nursing and Health Sciences, Faculty of Medicine, University of Rzeszow, Kopisto 2a, 35-959 Rzeszow, Poland.|Monash Biomedical Imaging, Monash University, Clayton, Victoria 3800, Australia.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Kolodziej
authors.affiliation: Institute of Nuclear Physics Polish Academy of Sciences, PL-31342 Krakow, Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Depciuch
authors.affiliation: Australian Synchrotron, 800 Blackburn Road, Clayton, Victoria 3168, Australia.
authors.forename: Jitraporn
authors.initials: J
authors.lastname: Vongsvivut
authors.affiliation: Centre for Innovation and Transfer of Natural Sciences and Engineering Knowledge, University of Rzeszow, Pigonia 1, 35-959 Rzeszow, Poland.
authors.forename: Marian
authors.initials: M
authors.lastname: Cholewa
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D018270:Carcinoma, Ductal, Breast / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D025341:Principal Component Analysis; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods*; D016896:Treatment Outcome; D064726:Triple Negative Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology