title: Herbal and Dietary Supplement-Induced Liver Injury.
abstract: The increase in the use of herbal and dietary supplements (HDSs) over the last decades has been accompanied by an increase in the reports of HDS-associated hepatotoxicity. The spectrum of HDS-induced liver injury is diverse and the outcome may vary from transient liver test increases to fulminant hepatic failure resulting in death or requiring liver transplant. There are no validated standardized tools to establish the diagnosis, but some HDS products have a typical clinical signature that may help to identify HDS-induced liver injury.
authors.affiliation: Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 10 Center Drive, Bethesda, MD 20814, USA; Department of Gastroenterology and Hepatology, VU University Medical Center, De Boelelaan 1117, Amsterdam 1081 HV, The Netherlands.
authors.forename: Ynto S
authors.initials: YS
authors.lastname: de Boer
authors.affiliation: Liver Diseases Research Branch, Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 6707 Democracy Boulevard, Room 6003, Bethesda, MD 20892-5450, USA. Electronic address: averell.sherker@nih.gov.
authors.forename: Averell H
authors.initials: AH
authors.lastname: Sherker
mesh_terms: D056486:Chemical and Drug Induced Liver Injury / Q000453:epidemiology* / Q000209:etiology* / Q000503:physiopathology; D019587:Dietary Supplements / Q000009:adverse effects*; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D028321:Plant Preparations / Q000009:adverse effects*; D018570:Risk Assessment; D014481:United States / Q000453:epidemiology
chemical_list: D028321:Plant Preparations
keywords: Dietary supplements; Drug-induced liver injury; Herbals; Liver; Toxicity