title: Explicating the Conditions Under Which Multilevel Multiple Imputation Mitigates Bias Resulting from Random Coefficient-Dependent Missing Longitudinal Data.
abstract: Random coefficient-dependent (RCD) missingness is a non-ignorable mechanism through which missing data can arise in longitudinal designs. RCD, for which we cannot test, is a problematic form of missingness that occurs if subject-specific random effects correlate with propensity for missingness or dropout. Particularly when covariate missingness is a problem, investigators typically handle missing longitudinal data by using single-level multiple imputation procedures implemented with long-format data, which ignores within-person dependency entirely, or implemented with wide-format (i.e., multivariate) data, which ignores some aspects of within-person dependency. When either of these standard approaches to handling missing longitudinal data is used, RCD missingness leads to parameter bias and incorrect inference. We explain why multilevel multiple imputation (MMI) should alleviate bias induced by a RCD missing data mechanism under conditions that contribute to stronger determinacy of random coefficients. We evaluate our hypothesis with a simulation study. Three design factors are considered: intraclass correlation (ICC; ranging from .25 to .75), number of waves (ranging from 4 to 8), and percent of missing data (ranging from 20 to 50%). We find that MMI greatly outperforms the single-level wide-format (multivariate) method for imputation under a RCD mechanism. For the MMI analyses, bias was most alleviated when the ICC is high, there were more waves of data, and when there was less missing data. Practical recommendations for handling longitudinal missing data are suggested.
authors.affiliation: Department of Health Behavior, University of North Carolina at Chapel Hill, Campus Box 7440, 135 Dauer Drive, Chapel Hill, NC, 27599-7440, USA. gottfredson@unc.edu.
authors.forename: Nisha C
authors.initials: NC
authors.lastname: Gottfredson
authors.affiliation: Vanderbilt University, Nashville, TN, USA.
authors.forename: Sonya K
authors.initials: SK
authors.lastname: Sterba
authors.affiliation: Brown University, Providence, RI, USA.
authors.forename: Kristina M
authors.initials: KM
authors.lastname: Jackson
mesh_terms: D015982:Bias; D003627:Data Interpretation, Statistical; D008137:Longitudinal Studies; D015233:Models, Statistical; D012107:Research Design
keywords: Determinacy; Longitudinal missing data; Multilevel multiple imputation; Random coefficient dependent