title: Differential Pattern of Cerebellar Atrophy in Tremor-Predominant and Akinetic/Rigidity-Predominant Parkinson's Disease.
abstract: Parkinson's disease (PD) is an akinetic-rigid disorder characterized by basal ganglia dysfunction and a possible cerebello-thalamo-cortical circuit involvement. This study aims to investigate the pattern of cerebellar involvement in PD and to assess whether it correlates with clinical parameters. MRI scans were acquired from 50 healthy controls (HC) and 63 patients; 44 were classified as tremor-predominant-PD (PDT) and 19 as akinetic/rigidity-predominant-PD (PDAR). We designed an analysis of covariance including the three groups and contrasted as follows: (1) all 63 PD vs HC, (2) PDT vs HC, (3) PDAR vs HC, and (4) PDT vs PDAR. For a precise evaluation of the cerebellum, we used the SUIT tool for voxel-based morphometry. Applying p = 0.001 and extent threshold = 20 voxels, the overall PD group vs HC showed decreased gray matter (GM) in the left lobules VI and crus I. The PDT group showed decreased cerebellar GM when compared with HC at left lobules VI, VIIb, and VIIIa; at right lobules Crus I, VIIb, and VIIIb; and vermal lobules VI and VIIIa. When compared with PDAR, PDT also showed a decrease in the left lobules VIIIa (p < 0.001). There were small clusters of both positive and negative correlation between disease duration and PDT group. The PDAR group showed no cerebellar changes. Our findings support the growing evidence of cerebellar involvement in the pathogenesis of the resting tremor.
authors.affiliation: Neuroimaging Laboratory, School of Medical Sciences, University of Campinas, Rua Vital Brasil, 251, Cidade Universitária, Campinas, SP, 13083-887, Brazil. camila.piccinin@gmail.com.
authors.forename: Camila Callegari
authors.initials: CC
authors.lastname: Piccinin
authors.affiliation: Department of Neurology, University of Campinas, Cidade Universitária, Campinas, SP, Brazil.
authors.forename: Lidiane Soares
authors.initials: LS
authors.lastname: Campos
authors.affiliation: Neuroimaging Laboratory, School of Medical Sciences, University of Campinas, Rua Vital Brasil, 251, Cidade Universitária, Campinas, SP, 13083-887, Brazil.
authors.forename: Rachel Paes
authors.initials: RP
authors.lastname: Guimarães
authors.affiliation: Department of Neurology, University of Campinas, Cidade Universitária, Campinas, SP, Brazil.
authors.forename: Luiza Gonzaga
authors.initials: LG
authors.lastname: Piovesana
authors.affiliation: Neuroimaging Laboratory, School of Medical Sciences, University of Campinas, Rua Vital Brasil, 251, Cidade Universitária, Campinas, SP, 13083-887, Brazil.
authors.forename: Maria Cristina Arci
authors.initials: MCA
authors.lastname: Dos Santos
authors.affiliation: Department of Neurology, University of Campinas, Cidade Universitária, Campinas, SP, Brazil.
authors.forename: Paula Christina
authors.initials: PC
authors.lastname: Azevedo
authors.affiliation: Neuroimaging Laboratory, School of Medical Sciences, University of Campinas, Rua Vital Brasil, 251, Cidade Universitária, Campinas, SP, 13083-887, Brazil.
authors.forename: Brunno Machado
authors.initials: BM
authors.lastname: Campos
authors.affiliation: Neuroimaging Laboratory, School of Medical Sciences, University of Campinas, Rua Vital Brasil, 251, Cidade Universitária, Campinas, SP, 13083-887, Brazil.
authors.forename: Thiago Junqueira Ribeiro
authors.initials: TJR
authors.lastname: de Rezende
authors.affiliation: Department of Radiology, University of Campinas, Cidade Universitária, Campinas, SP, Brazil.
authors.forename: Augusto
authors.initials: A
authors.lastname: Amato-Filho
authors.affiliation: Neuroimaging Laboratory, School of Medical Sciences, University of Campinas, Rua Vital Brasil, 251, Cidade Universitária, Campinas, SP, 13083-887, Brazil.|Department of Neurology, University of Campinas, Cidade Universitária, Campinas, SP, Brazil.
authors.forename: Fernando
authors.initials: F
authors.lastname: Cendes
authors.affiliation: Neuroimaging Laboratory, School of Medical Sciences, University of Campinas, Rua Vital Brasil, 251, Cidade Universitária, Campinas, SP, 13083-887, Brazil.|Department of Neurology, University of Campinas, Cidade Universitária, Campinas, SP, Brazil.
authors.forename: Anelyssa
authors.initials: A
authors.lastname: D'Abreu
mesh_terms: D000328:Adult; D000368:Aged; D001284:Atrophy; D001931:Brain Mapping; D002526:Cerebellar Diseases / Q000473:pathology; D002531:Cerebellum / Q000473:pathology; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D009434:Neural Pathways / Q000473:pathology* / Q000503:physiopathology; D010300:Parkinson Disease / Q000473:pathology* / Q000503:physiopathology; D014202:Tremor / Q000473:pathology* / Q000503:physiopathology
keywords: Cerebellum; Parkinson’s disease; Resting tremor; Suit; Voxel-based morphometry