title: Evaluation of glutathione-binding protein A of Haemophilus parasuis as a vaccine candidate in a mouse model.
abstract: The virulent strains of Haemophilus parasuis are the causative agents of Glässer's disease, which can cause systemic infection and result in polyserositis, meningitis and arthritis. The development of novel, effective vaccines would be beneficial to preventing H. parasuis infections. Here, we report a novel immunogenic protein, glutathione-binding protein A (GbpA), which can elicit a significant humoral antibody response and confer significant protection against challenge with a lethal dose of a highly virulent H. parasuis strain. The H. parasuis strain can be fully eliminated in the immunized mice. The results indicate that GbpA has the potential to be used as an effective component of a new vaccine against H. parasuis.
authors.affiliation: Division of Bacterial Diseases, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences, Harbin, People's Republic of China.
authors.forename: Yanhe
authors.initials: Y
authors.lastname: Zhang
authors.forename: Gang
authors.initials: G
authors.lastname: Li
authors.forename: Fang
authors.initials: F
authors.lastname: Xie
authors.forename: Siguo
authors.initials: S
authors.lastname: Liu
authors.forename: Chunlai
authors.initials: C
authors.lastname: Wang
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000276:immunology* / Q000302:isolation & purification; D015153:Blotting, Western / Q000662:veterinary; D004195:Disease Models, Animal; D004591:Electrophoresis, Polyacrylamide Gel / Q000662:veterinary; D005260:Female; D006192:Haemophilus Infections / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary*; D018073:Haemophilus Vaccines / Q000276:immunology* / Q000627:therapeutic use; D044137:Haemophilus parasuis / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D013552:Swine; D013553:Swine Diseases / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control
chemical_list: D001426:Bacterial Proteins; D018073:Haemophilus Vaccines