title: How Subclonal Modeling Is Changing the Metastatic Paradigm.
abstract: A concerted effort to sequence matched primary and metastatic tumors is vastly improving our ability to understand metastasis in humans. Compelling evidence has emerged that supports the existence of diverse and surprising metastatic patterns. Enhancing these efforts is a new class of algorithms that facilitate high-resolution subclonal modeling of metastatic spread. Here we summarize how subclonal models of metastasis are influencing the metastatic paradigm. Clin Cancer Res; 23(3); 630-5. ©2016 AACR.
authors.affiliation: Cancer Research UK Cambridge Institute, University of Cambridge, United Kingdom.
authors.forename: Geoff
authors.initials: G
authors.lastname: Macintyre
authors.affiliation: The Francis Crick Institute, London, United Kingdom.|Department of Human Genetics, University of Leuven, Leuven, Belgium.
authors.forename: Peter
authors.initials: P
authors.lastname: Van Loo
authors.affiliation: Department of Surgery, The University of Melbourne, The Royal Melbourne Hospital, Parkville, Australia.|Australian Prostate Cancer Research Centre at Epworth Hospital, Australia.
authors.forename: Niall M
authors.initials: NM
authors.lastname: Corcoran
authors.affiliation: Oxford Big Data Institute, Wellcome Trust Centre for Human Genetics, Oxford, United Kingdom.
authors.forename: David C
authors.initials: DC
authors.lastname: Wedge
authors.affiliation: Cancer Research UK Cambridge Institute, University of Cambridge, United Kingdom. chovens@unimelb.edu.au florian.markowetz@cruk.cam.ac.uk.
authors.forename: Florian
authors.initials: F
authors.lastname: Markowetz
authors.affiliation: Department of Surgery, The University of Melbourne, The Royal Melbourne Hospital, Parkville, Australia. chovens@unimelb.edu.au florian.markowetz@cruk.cam.ac.uk.|Australian Prostate Cancer Research Centre at Epworth Hospital, Australia.
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Hovens
mesh_terms: D000465:Algorithms; D000818:Animals; D002450:Cell Communication; D019070:Cell Lineage; D002999:Clone Cells / Q000473:pathology; D004252:DNA Mutational Analysis; D004273:DNA, Neoplasm / Q000235:genetics; D018450:Disease Progression; D006801:Humans; D051379:Mice; D008954:Models, Biological; D009154:Mutation; D009362:Neoplasm Metastasis / Q000235:genetics / Q000473:pathology* / Q000503:physiopathology; D009360:Neoplastic Cells, Circulating; D014411:Neoplastic Stem Cells / Q000473:pathology*; D017422:Sequence Analysis, DNA; D013997:Time Factors; D000073336:Whole Genome Sequencing
chemical_list: D004273:DNA, Neoplasm