title: Altered local spontaneous activity in frontal lobe epilepsy: a resting-state functional magnetic resonance imaging study.
abstract: The purpose of this study was to investigate the local spatiotemporal consistency of spontaneous brain activity in patients with frontal lobe epilepsy (FLE).
  
  
  
  Eyes closed resting-state functional magnetic resonance imaging (fMRI) data were collected from 19 FLE patients and 19 age- and gender-matched healthy controls. A novel measure, named FOur-dimensional (spatiotemporal) Consistency of local neural Activities (FOCA) was used to assess the spatiotemporal consistency of local spontaneous activity (emphasizing both local temporal homogeneity and regional stability of brain activity states). Then, two-samplettest was performed to detect the FOCA differences between two groups. Partial correlations between the FOCA values and durations of epilepsy were further analyzed.
  
  
  
  Compared with controls, FLE patients demonstrated increased FOCA in distant brain regions including the frontal and parietal cortices, as well as the basal ganglia. The decreased FOCA was located in the temporal cortex, posterior default model regions, and cerebellum. In addition, the FOCA measure was linked to the duration of epilepsy in basal ganglia.
  
  
  
  Our study suggested that alterations of local spontaneous activity in frontoparietal cortex and basal ganglia was associated with the pathophysiology of FLE; and the abnormality in frontal and default model regions might account for the potential cognitive impairment in FLE. We also presumed that the FOCA measure had potential to provide important insights into understanding epilepsy such as FLE.
authors.affiliation: Key Laboratory for NeuroInformation of Ministry of Education Center for Information in Medicine, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province School of Life Science and Technology University of Electronic Science and Technology of China Chengdu China.
authors.forename: Li
authors.identifier: 0000-0002-2059-8842
authors.initials: L
authors.lastname: Dong
authors.affiliation: Key Laboratory for NeuroInformation of Ministry of Education Center for Information in Medicine, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province School of Life Science and Technology University of Electronic Science and Technology of China Chengdu China.
authors.forename: Hechun
authors.initials: H
authors.lastname: Li
authors.affiliation: Key Laboratory for NeuroInformation of Ministry of Education Center for Information in Medicine, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province School of Life Science and Technology University of Electronic Science and Technology of China Chengdu China.
authors.forename: Zhongqiong
authors.initials: Z
authors.lastname: He
authors.affiliation: Key Laboratory for NeuroInformation of Ministry of Education Center for Information in Medicine, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province School of Life Science and Technology University of Electronic Science and Technology of China Chengdu China.
authors.forename: Sisi
authors.initials: S
authors.lastname: Jiang
authors.affiliation: Key Laboratory for NeuroInformation of Ministry of Education Center for Information in Medicine, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province School of Life Science and Technology University of Electronic Science and Technology of China Chengdu China.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Klugah-Brown
authors.affiliation: Key Laboratory for NeuroInformation of Ministry of Education Center for Information in Medicine, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province School of Life Science and Technology University of Electronic Science and Technology of China Chengdu China.
authors.forename: Lin
authors.initials: L
authors.lastname: Chen
authors.affiliation: Key Laboratory for NeuroInformation of Ministry of Education Center for Information in Medicine, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province School of Life Science and Technology University of Electronic Science and Technology of China Chengdu China.
authors.forename: Pu
authors.initials: P
authors.lastname: Wang
authors.affiliation: Key Laboratory for NeuroInformation of Ministry of Education Center for Information in Medicine, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province School of Life Science and Technology University of Electronic Science and Technology of China Chengdu China.
authors.forename: Song
authors.initials: S
authors.lastname: Tan
authors.affiliation: Key Laboratory for NeuroInformation of Ministry of Education Center for Information in Medicine, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province School of Life Science and Technology University of Electronic Science and Technology of China Chengdu China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Luo
authors.affiliation: Key Laboratory for NeuroInformation of Ministry of Education Center for Information in Medicine, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province School of Life Science and Technology University of Electronic Science and Technology of China Chengdu China.
authors.forename: Dezhong
authors.initials: D
authors.lastname: Yao
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D017034:Epilepsy, Frontal Lobe / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D005260:Female; D005625:Frontal Lobe / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D055815:Young Adult
keywords: FOur‐dimensional (spatiotemporal) Consistency of local neural Activities; frontal lobe epilepsy; functional magnetic resonance imaging; resting‐state