title: Normalized resistance interpretation, the NRI method: Review of NRI disc test applications and guide to calculations.
abstract: The normalized resistance interpretation (NRI) method was developed in response to a call for a method to calibrate disc diffusion test results making inter-laboratory comparisons possible. The main use of NRI so far has been in individual laboratories, in medical and veterinary medicine and in the field of marine microbiology. The applications of NRI for disc diffusion tests are reviewed and, in addition, a detailed description of the calculation procedure is presented. NRI provides a fully objective method for ECOFF calculations of disc diffusion antimicrobial susceptibility test results.
authors.affiliation: Department of Laboratory Medicine, Karolinska Institute, Stockholm, Sweden.
authors.forename: Göran
authors.initials: G
authors.lastname: Kronvall
authors.affiliation: Department of Microbiology, School of Natural Sciences, National University of Ireland, Galway, Ireland.
authors.forename: Peter
authors.initials: P
authors.lastname: Smith
mesh_terms: D001419:Bacteria / Q000145:classification / Q000187:drug effects*; D052978:Disk Diffusion Antimicrobial Tests / Q000379:methods* / Q000592:standards*; D024881:Drug Resistance, Bacterial
keywords: Normalized resistance interpretation; antimicrobial susceptibility testing; disc test calibration; epidemiological cut-off value