title: Thromboembolism in Dogs with Protein-Losing Enteropathy with Non-Neoplastic Chronic Small Intestinal Disease.
abstract: Dogs with protein-losing enteropathy (PLE) are suggested to be at increased risk of developing thromboembolic events. However, with some exceptions, there are very few reports of thromboembolism in such dogs. This multicentre retrospective observational study describes a case series of thromboembolism (TE) in eight dogs with PLE secondary to non-neoplastic, chronic small intestinal disease. Seven dogs had poorly controlled PLE when the thromboembolic event occurred. Pulmonary thromboembolism (PTE) occurred in six dogs, while one dog developed splenic vein thrombosis and another had concurrent splenic vein and aortic TE. Six dogs died, all with PTE. Antithrombin activity was decreased in one of two dogs in which it was measured. Serum cobalamin and folate concentrations were measured in three dogs and cobalamin was subnormal in all three. Serum magnesium, measured in two dogs, was low in both. Dogs with uncontrolled chronic small intestinal disease and PLE are at risk for developing serious life-threatening TE, mostly PTE.
authors.forename: Ana M L
authors.initials: AML
authors.lastname: Jacinto
authors.affiliation: From the Division of Veterinary Clinical Sciences (A.M.L.J., A.E.R., M.L.C.) and Easter Bush Pathology (L.R.M.), Royal (Dick) School of Veterinary Studies and the Roslin Institute, University of Edinburgh, Edinburgh, Scotland, United Kingdom; Koret School of Veterinary Medicine, the Robert H. Smith Faculty of Agricultural, the Hebrew University of Jerusalem, Rehovot, Israel (S.K., I.A.); and the Queen's Veterinary School Hospital, University of Cambridge, Cambridge, England, United Kingdom (P.J.W.).
authors.forename: Alison E
authors.initials: AE
authors.lastname: Ridyard
authors.forename: Itamar
authors.initials: I
authors.lastname: Aroch
authors.affiliation: From the Division of Veterinary Clinical Sciences (A.M.L.J., A.E.R., M.L.C.) and Easter Bush Pathology (L.R.M.), Royal (Dick) School of Veterinary Studies and the Roslin Institute, University of Edinburgh, Edinburgh, Scotland, United Kingdom; Koret School of Veterinary Medicine, the Robert H. Smith Faculty of Agricultural, the Hebrew University of Jerusalem, Rehovot, Israel (S.K., I.A.); and the Queen's Veterinary School Hospital, University of Cambridge, Cambridge, England, United Kingdom (P.J.W.).
authors.forename: Penny J
authors.initials: PJ
authors.lastname: Watson
authors.affiliation: From the Division of Veterinary Clinical Sciences (A.M.L.J., A.E.R., M.L.C.) and Easter Bush Pathology (L.R.M.), Royal (Dick) School of Veterinary Studies and the Roslin Institute, University of Edinburgh, Edinburgh, Scotland, United Kingdom; Koret School of Veterinary Medicine, the Robert H. Smith Faculty of Agricultural, the Hebrew University of Jerusalem, Rehovot, Israel (S.K., I.A.); and the Queen's Veterinary School Hospital, University of Cambridge, Cambridge, England, United Kingdom (P.J.W.).
authors.forename: Linda R
authors.initials: LR
authors.lastname: Morrison
authors.affiliation: From the Division of Veterinary Clinical Sciences (A.M.L.J., A.E.R., M.L.C.) and Easter Bush Pathology (L.R.M.), Royal (Dick) School of Veterinary Studies and the Roslin Institute, University of Edinburgh, Edinburgh, Scotland, United Kingdom; Koret School of Veterinary Medicine, the Robert H. Smith Faculty of Agricultural, the Hebrew University of Jerusalem, Rehovot, Israel (S.K., I.A.); and the Queen's Veterinary School Hospital, University of Cambridge, Cambridge, England, United Kingdom (P.J.W.).
authors.forename: Marge L
authors.initials: ML
authors.lastname: Chandler
authors.affiliation: From the Division of Veterinary Clinical Sciences (A.M.L.J., A.E.R., M.L.C.) and Easter Bush Pathology (L.R.M.), Royal (Dick) School of Veterinary Studies and the Roslin Institute, University of Edinburgh, Edinburgh, Scotland, United Kingdom; Koret School of Veterinary Medicine, the Robert H. Smith Faculty of Agricultural, the Hebrew University of Jerusalem, Rehovot, Israel (S.K., I.A.); and the Queen's Veterinary School Hospital, University of Cambridge, Cambridge, England, United Kingdom (P.J.W.).
authors.forename: Sharon
authors.initials: S
authors.lastname: Kuzi
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000209:etiology* / Q000473:pathology; D004285:Dogs; D005260:Female; D007421:Intestine, Small / Q000473:pathology*; D008297:Male; D064887:Observational Studies as Topic; D011504:Protein-Losing Enteropathies / Q000150:complications / Q000662:veterinary*; D012189:Retrospective Studies; D013923:Thromboembolism / Q000150:complications / Q000662:veterinary*