title: Effect of O-methylated and glucuronosylated flavonoids from Tamarix gallica on α-glucosidase inhibitory activity: structure-activity relationship and synergistic potential.
abstract: O-Methylated and glucuronosylated flavonoids were isolated from Tamarix gallica as α-glucosidase inhibitors. Structure-activity relationship of these flavonoids suggests that catechol moiety and glucuronic acid at C-3 are factors in the increase in α-glucosidase inhibitory activity. Furthermore, rhamnetin, tamarixetin, rhamnazin, KGlcA, KGlcA-Me, QGlcA, and QGlcA-Me exhibit synergistic potential when applied with a very low concentration of acarbose to α-glucosidase from rat intestine.
authors.affiliation: a Graduate School of Life and Environmental Sciences , University of Tsukuba , Tsukuba , Japan.
authors.forename: Asma
authors.initials: A
authors.lastname: Ben Hmidene
authors.affiliation: b Laboratoire des Plantes Extrêmophiles , Centre de Biotechnologie à la Technopole de BorjCêdria (CBBC) , Hammam-Lif , Tunisia.
authors.forename: Abderrazak
authors.initials: A
authors.lastname: Smaoui
authors.affiliation: b Laboratoire des Plantes Extrêmophiles , Centre de Biotechnologie à la Technopole de BorjCêdria (CBBC) , Hammam-Lif , Tunisia.
authors.forename: Chedly
authors.initials: C
authors.lastname: Abdelly
authors.affiliation: c Alliance for Research on North Africa (ARENA), University of Tsukuba , Tsukuba , Japan.|d Faculty of Life and Environmental Sciences , University of Tsukuba , Tsukuba , Japan.
authors.forename: Hiroko
authors.initials: H
authors.lastname: Isoda
authors.affiliation: d Faculty of Life and Environmental Sciences , University of Tsukuba , Tsukuba , Japan.
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Shigemori
mesh_terms: D004305:Dose-Response Relationship, Drug; D005419:Flavonoids / Q000737:chemistry* / Q000494:pharmacology*; D065089:Glycoside Hydrolase Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D032363:Tamaricaceae / Q000737:chemistry*; D000520:alpha-Glucosidases / Q000378:metabolism
chemical_list: D005419:Flavonoids; D065089:Glycoside Hydrolase Inhibitors; D000520:alpha-Glucosidases
keywords: O-methylated and glucuronosylated flavonoids; Tamarix gallica; structure–activity relationship and synergistic potential; α-glucosidase inhibitors