title: The effect of vitamin D supplementation on hypertension in non-CKD populations: A systemic review and meta-analysis.
abstract: OBJECTIVE
  To investigate the vitamin D supplementation on blood pressure control by a systemic review and meta-analysis.
  
  
  METHODS
  Randomized controlled clinical trials were analyzed, which date from eight studies in databases including MEDLINE, EMBASE, Clinical trials, China Integrated Knowledge Resources Database and the Cochrane library.
  
  
  RESULTS
  Total 917 patients from eight randomized controlled trials (RCTs), treatment with vitamin D for more than 3months were analyzed. Meta-analysis showed that vitamin D supplementation slightly reduced the systolic blood pressure (SBP) by 1.964mmHg (95% CI, 0.362-3.566; P=0.016), but not lowered diastolic blood pressure (SMD: -0.087, 95% CI, -0.208-0.033; P=0.155). Subgroup analysis also showed that sBP lowering by vitamin D supplementation was not dose-dependent. Comparison to placebo, there is also no statistical difference in SBP lowering by vitamin D supplementation.
  
  
  CONCLUSIONS
  This meta-analysis indicated that vitamin D is not an antihypertensive agent although it has a moderate SBP lowering effect. More RCTs are required to observe the role of vitamin D plus other antihypertensive drugs in blood pressure control, and define the optimum dose, dosing interval, and type of vitamin D to administer.
authors.affiliation: Hypertension Center, Fuwai Hospital, State Key Laboratory of Cardiovascular Disease of China, National Center for Cardiovascular Diseases of China, Chinese Academy of Medical Sciences and Peking Union Medical College, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Qi
authors.affiliation: Hypertension Center, Fuwai Hospital, State Key Laboratory of Cardiovascular Disease of China, National Center for Cardiovascular Diseases of China, Chinese Academy of Medical Sciences and Peking Union Medical College, China.
authors.forename: Xiaolu
authors.initials: X
authors.lastname: Nie
authors.affiliation: Hypertension Center, Fuwai Hospital, State Key Laboratory of Cardiovascular Disease of China, National Center for Cardiovascular Diseases of China, Chinese Academy of Medical Sciences and Peking Union Medical College, China. Electronic address: caijun@fuwaihospital.org.
authors.forename: Jun
authors.initials: J
authors.lastname: Cai
mesh_terms: D001794:Blood Pressure / Q000187:drug effects; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000517:prevention & control; D008297:Male; D016032:Randomized Controlled Trials as Topic; D012680:Sensitivity and Specificity; D014807:Vitamin D / Q000008:administration & dosage*
chemical_list: D014807:Vitamin D
keywords: Hypertension; Meta-analysis; Systemic review; Vitamin D