title: Slow-Growing Mediastinal Grey Zone Lymphoma Originating From a Formerly Resected Multilocular Thymic Cyst.
abstract: We report a unique case of mediastinal grey zone lymphoma that was considered to originate from CD20+CD30+Hodgkin cell-like cells associated with a multilocular thymic cyst that had been completely removed 4 years previously. In the formerly resected thymus, irregular-shaped cysts were observed, and large CD20+CD30+Hodgkin cell-like cells proliferated in close association with the proliferating thymic epithelial cells. This case suggests the important role of thymic columnar epithelial cells in the proliferation of thymic B cells and the tumorigenesis of mediastinal grey zone lymphoma. Also, it suggests that mediastinal grey zone lymphoma can proliferate slowly in the very early stage.
authors.affiliation: Department of Hematology and Oncology, Hyogo Prefectural Tsukaguchi Hospital, Hyogo, Japan. Electronic address: rita0248@yahoo.co.jp.
authors.forename: Rie
authors.initials: R
authors.lastname: Tabata
authors.affiliation: Cancer Center, Hyogo College of Medicine, Hyogo, Japan.
authors.forename: Chiharu
authors.initials: C
authors.lastname: Tabata
authors.affiliation: Department of Surgical Pathology, Hyogo College of Medicine, Hyogo, Japan.
authors.forename: Yoshitane
authors.initials: Y
authors.lastname: Tsukamoto
authors.affiliation: Department of Thoracic Surgery, Hyogo College of Medicine, Hyogo, Japan.
authors.forename: Masaki
authors.initials: M
authors.lastname: Hashimoto
authors.affiliation: Department of Pathology, Hyogo Prefectural Tsukaguchi Hospital, Hyogo, Japan.
authors.forename: Ryoji
authors.initials: R
authors.lastname: Yasumizu
authors.affiliation: Department of Anatomic and Diagnostic Pathology, Dokkyo Medical University School of Medicine, Tochigi, Japan.
authors.forename: Masaru
authors.initials: M
authors.lastname: Kojima
mesh_terms: D006801:Humans; D008223:Lymphoma / Q000000981:diagnostic imaging / Q000473:pathology*; D008476:Mediastinal Cyst / Q000150:complications / Q000601:surgery*; D008479:Mediastinal Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D008875:Middle Aged; D011183:Postoperative Complications; D014057:Tomography, X-Ray Computed