title: Synthesis, Photophysical and Photochemical Properties of a Set of Silicon Phthalocyanines Bearing Anti-Inflammatory Groups.
abstract: In this study, a series of novel silicon (IV) phthalocyanines conjugated axially with anti-inflammatory (sulindac) and triethylene glycol groups has been synthesized. Different synthetic strategies were attempted to obtain the targeted molecules in high yield. The compounds were fully characterized by using different analyses techniques. Our objectives were to generate a system with sulindac group which enhances the singlet oxygen generation and exhibits anti-cancer effect. Therefore, photophysical and photochemical properties of these compounds were investigated in different solvents. The substituent effect on fluorescence quantum yield and singlet oxygen generation was evaluated for efficiency in photodynamic therapy (PDT) as photosensitizer. The molecules exhibited no aggregation tendency, solubility in common organic solvents, high singlet oxygen quantum yield and high photostability in DMSO so these favourable properties make them good candidates as photosensitizer for PDT. In addition, their stabilities were investigated in DMSO, THF, acetonitrile and DMF.
authors.affiliation: Department of Chemistry, Gebze Technical University, Gebze, 41400, Kocaeli, Turkey.
authors.forename: Belgin
authors.initials: B
authors.lastname: Şahin
authors.affiliation: Department of Chemistry, Gebze Technical University, Gebze, 41400, Kocaeli, Turkey.
authors.forename: Sevinc Zehra
authors.initials: SZ
authors.lastname: Topal
authors.affiliation: Department of Chemistry, Gebze Technical University, Gebze, 41400, Kocaeli, Turkey. datilla@gtu.edu.tr.
authors.forename: Devrim
authors.initials: D
authors.lastname: Atilla
mesh_terms: D000893:Anti-Inflammatory Agents / Q000737:chemistry*; D005453:Fluorescence; D006801:Humans; D007211:Indoles / Q000737:chemistry*; D017646:Organosilicon Compounds / Q000737:chemistry*; D010778:Photochemotherapy; D010782:Photolysis; D017319:Photosensitizing Agents / Q000737:chemistry*; D026082:Singlet Oxygen / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry*
chemical_list: D000893:Anti-Inflammatory Agents; D007211:Indoles; D017646:Organosilicon Compounds; D017319:Photosensitizing Agents; D012997:Solvents; C082854:silicon phthalocyanine; D026082:Singlet Oxygen
keywords: Anti-inflammatory; Photochemical; Photophysical; Phthalocyanine; Silicon; Singlet oxygen