title: Adequate Vitamin D Intake but Low Serum Levels in Pediatric Asthma Patients: A Pilot Study, Alberta Children's Hospital.
abstract: Background. We assessed vitamin D intakes and serum 25(OH) vitamin D levels in pediatric asthma patients on moderate-to-high dose inhaled steroids and compared them to published findings of healthy children in our city.Methods. Parents and/or patients were interviewed to estimate the children's vitamin D intakes from foods and supplements (using an adapted validated food frequency questionnaire) and asthma duration and management. Vitamin D status: serum 25-hyroxy vitamin D (25(OH)D) was obtained from the medical records.Results. Vitamin D intakes from food and supplements of the asthma patients (n= 20, 742 ± 185 IU/day) were significantly higher compared to healthy Canadian children (n= 1442, 229 ± 121 IU/day). Despite higher vitamin D intakes, the children had nonsignificantly lower serum 25(OH) vitamin D levels compared to the comparison group. Serum 25(OH)D levels increased by 3.6 nmol/L with each 100 IU of vitamin D intake (95% Confidence interval = 2.0-4.0,R2= 0.931, andp= 0.001).Conclusion. Since adequate vitamin D status in asthma patients is necessary to support bone mineral accretion, it is important to achieve adequate vitamin D status by checking serum 25(OH)D status and supplement accordingly.
authors.affiliation: Alberta Children's Hospital, 2888 Shaganappi Trail NW, Calgary, AB, Canada T3B 6A8; Nutrition Services, Alberta Health Services, Calgary, AB, Canada.
authors.forename: Sarah
authors.identifier: 0000-0002-6340-7583
authors.initials: S
authors.lastname: Howe McKenna
authors.affiliation: Nutrition Services, Alberta Health Services, Calgary, AB, Canada; Alberta Children's Hospital Research Institute, O'Brien Institute of Public Health and Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
authors.forename: Tanis R
authors.identifier: 0000-0001-9585-9149
authors.initials: TR
authors.lastname: Fenton
authors.affiliation: Respirology, Alberta Children's Hospital, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
authors.forename: Mary
authors.initials: M
authors.lastname: Noseworthy
authors.affiliation: Respirology, Alberta Children's Hospital, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
authors.forename: Mark
authors.initials: M
authors.lastname: Anselmo
mesh_terms: D000280:Administration, Inhalation; D000293:Adolescent; D000416:Alberta / Q000453:epidemiology; D001249:Asthma / Q000097:blood* / Q000188:drug therapy / Q000453:epidemiology; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D004032:Diet; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006776:Hospitals, Pediatric; D006801:Humans; D008297:Male; D010865:Pilot Projects; D011446:Prospective Studies; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood* / Q000453:epidemiology
chemical_list: D005938:Glucocorticoids; D014807:Vitamin D; C104450:25-hydroxyvitamin D