title: E-cadherin-160 C/A genotypes and cervical intraepithelial neoplasia.
abstract: OBJECTIVE
  E-cadherin is a transmembrane glycoprotein with important roles in the maintenance of cervical squamous epithelium integrity. The purpose of this study was to investigate the relationship between E-cadherin-160 C/A polymorphism and cervical intraepithelial neoplasia (CIN).
  
  
  METHODS
  A case-control study was performed enrolling 70 CIN cases and 107 age-matched healthy controls. Each patient was examined colposcopically, having a cervical specimen. All patients and controls have been genotyped for E-cadherin-160. Data were analysed using odds ratios (OR) and chi-square test at a significance level of p<0.005.
  
  
  RESULTS
  The presence of E-cadherin-160 C/A was significantly associated with high-grade squamous intraepithelial lesion (HSIL) (OR=2.7916, 95% CI 1.1495,6.9345, x2=6.33, p=0.0118) and carcinoma in situ (CIS) (OR=2.5617, 95% CI 1.1676,5.6705, x2=6.63, p=0.0100). The detection of either CA or AA genotype was also significantly associated with HSIL and CIS.
  
  
  CONCLUSIONS
  E-cadherin-160 genotype represents a valid risk factor for HSIL and CIS.
authors.affiliation: 1st Clinic of Obstetrics and Gynecology, University of Medicine and Pharmacy "Iuliu Hatieganu", Cluj-Napoca, Romania.
authors.forename: Ioana
authors.initials: I
authors.lastname: Cristina Rotar
authors.forename: Daniel
authors.initials: D
authors.lastname: Muresan
authors.forename: Diana
authors.initials: D
authors.lastname: Elena Dumitras
authors.forename: Anghel
authors.initials: A
authors.lastname: Popp Radu
authors.forename: Felicia
authors.initials: F
authors.lastname: Maria Petrisor
authors.forename: Florin
authors.initials: F
authors.lastname: Stamatian
mesh_terms: D000328:Adult; D015703:Antigens, CD; D014408:Biomarkers, Tumor / Q000235:genetics*; D015820:Cadherins / Q000235:genetics*; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D003127:Colposcopy; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D008875:Middle Aged; D016017:Odds Ratio; D010641:Phenotype; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D012307:Risk Factors; D012383:Romania; D065310:Squamous Intraepithelial Lesions of the Cervix / Q000235:genetics* / Q000473:pathology; D002583:Uterine Cervical Neoplasms / Q000235:genetics* / Q000473:pathology; D002578:Uterine Cervical Dysplasia / Q000235:genetics* / Q000473:pathology
chemical_list: D015703:Antigens, CD; D014408:Biomarkers, Tumor; C513384:CDH1 protein, human; D015820:Cadherins