title: Glioblastoma Secondary to Meningioma: A Case Report and Literature Review.
abstract: BACKGROUND
  The pathophysiologies underlying meningioma and glioma are distinct. The coexistence of those 2 lesions in the same patient is rare, and at the same location, it is even more exceptional.
  
  
  METHODS
  We report a case of a 79-year-old man initially presenting with a meningioma that was treated by complete excision of the lesion. The patient had 2 relapses at the same site, in which glioblastoma was confirmed histopathologically.
  
  
  CONCLUSIONS
  Glial transformation meningiomas remain a contentious issue, with coincidental occurrence being the most prevalent explanation. Nevertheless, impairment of the same molecular signaling pathways in both tumor types suggests a common origin. Another hypothesis is that perilesional parenchymal damage from radiotherapy or surgery may lead to glial transformation in the tissues surrounding the original meningioma lesion. Further research is needed to determine if the original tumor or surgery has an oncogenic effect on the adjacent tissue.
authors.affiliation: Department of Neurology, Sainte-Anne French Military Teaching Hospital, Toulon, France. Electronic address: paulinesahuc@hotmail.fr.
authors.forename: Pauline
authors.initials: P
authors.lastname: Sahuc
authors.affiliation: Department of Neurosurgery, Sainte-Anne French Military Teaching Hospital, Toulon, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Joubert
authors.affiliation: Department of Anatomopathology, Sainte-Anne French Military Teaching Hospital, Toulon, France.
authors.forename: Anh-Tuan
authors.initials: AT
authors.lastname: Nguyen
authors.affiliation: Department of Anatomopathology, Sainte-Anne French Military Teaching Hospital, Toulon, France.
authors.forename: Bernard
authors.initials: B
authors.lastname: Fouet
authors.affiliation: Department of Neurology, Sainte-Anne French Military Teaching Hospital, Toulon, France.
authors.forename: Delphine
authors.initials: D
authors.lastname: Wybrecht
authors.affiliation: Department of Neurology, Sainte-Anne French Military Teaching Hospital, Toulon, France.
authors.forename: Anthony
authors.initials: A
authors.lastname: Faivre
authors.affiliation: Department of Neurology, Sainte-Anne French Military Teaching Hospital, Toulon, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Alla
authors.affiliation: Department of Neurosurgery, Sainte-Anne French Military Teaching Hospital, Toulon, France.
authors.forename: Arnaud
authors.initials: A
authors.lastname: Dagain
mesh_terms: D000368:Aged; D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000556:secondary*; D003606:Dacarbazine / Q000031:analogs & derivatives / Q000627:therapeutic use; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D005909:Glioblastoma / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000556:secondary*; D006801:Humans; D019394:Ki-67 Antigen / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D008297:Male; D008577:Meningeal Neoplasms / Q000473:pathology*; D008579:Meningioma / Q000473:pathology*; D018396:Mucin-1 / Q000378:metabolism; D000077204:Temozolomide
chemical_list: D018906:Antineoplastic Agents, Alkylating; D005904:Glial Fibrillary Acidic Protein; D019394:Ki-67 Antigen; D018396:Mucin-1; D003606:Dacarbazine; D000077204:Temozolomide
keywords: Glioblastoma; Meningioma; Tumorigenesis