title: Characteristics of erythrocyte-derived microvesicles and its relation with atherosclerosis.
abstract: Microvesicles are formed under many circumstances, especially in atheromatous plaques. Erythrocyte-derived microvesicles (ErMVs) have been proved to promote atherosclerosis by promoting hypercoagulation, mediating inflammation and inducing cell adhesion. Several clinical studies have reported potential roles of ErMVs in cardiovascular disease diagnosis, but the current understanding of ErMVs remains insufficient. In this paper, we will review current research on the formation and degradation of ErMVs and the possible effects of ErMVs in atherosclerosis, discuss potential clinical applications in cardiovascular disease, and hope to raise awareness of the relation with atherosclerosis.
authors.affiliation: Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, University of South China, Hengyang, Hunan, China.
authors.forename: Kai-Yin
authors.initials: KY
authors.lastname: Li
authors.affiliation: Laboratory Medicine Center, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zheng
authors.affiliation: Laboratory Medicine Center, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Laboratory Medicine Center, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China. Electronic address: ywhu0618@163.com.
authors.forename: Yan-Wei
authors.initials: YW
authors.lastname: Hu
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000097:blood* / Q000473:pathology; D015415:Biomarkers / Q000097:blood; D001777:Blood Coagulation; D002448:Cell Adhesion; D055252:Cell-Derived Microparticles / Q000378:metabolism* / Q000473:pathology; D004912:Erythrocytes / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007249:Inflammation / Q000378:metabolism / Q000473:pathology; D018836:Inflammation Mediators / Q000097:blood; D058226:Plaque, Atherosclerotic; D011237:Predictive Value of Tests; D015398:Signal Transduction
chemical_list: D015415:Biomarkers; D018836:Inflammation Mediators
keywords: Adhesion; Atherosclerosis; Coagulation; Erythrocyte-derived microvesicles; Inflammation