title: Serum adiponectin levels in gestational diabetes mellitus.
abstract: BACKGROUND
  Gestational diabetes mellitus (GDM) is defined as any degree of glucose intolerance with onset or first recognition during pregnancy.[1]Pregnancy is a unique situation in which there is a physiological temporary increase in insulin resistance (IR). The mechanisms responsible for the gestational-induced IR are not completely understood. The current study was undertaken to compare adiponectin levels during 24-28 weeks period of gestation in drug-naive newly diagnosed GDM women with a cohort of normoglycemic pregnant women.
  
  
  METHODS
  A total of 47 pregnant women in the age group of 18-40 years were included in this cross-sectional study, of which 13 were GDM cases and 34 were normoglycemic controls. Serum adiponectin level was analyzed by enzyme-linked immunosorbent assay.
  
  
  RESULTS
  The mean adiponectin level was 16.92 ng/ml (standard deviation [SD] = 2.78) and 19.38 ng/ml (SD = 2.71) in case and control groups, respectively, and the difference was found to be statistically significant (P= 0.008).
  
  
  CONCLUSIONS
  Our study demonstrated decreased serum adiponectin levels in women with GDM when compared with age- and body mass index-matched euglycemic pregnant women.
authors.affiliation: Department of Endocrinology, M.S. Ramaiah Medical College, Bengaluru, Karnataka, India.
authors.forename: Abhijit
authors.initials: A
authors.lastname: Bhograj
authors.affiliation: Department of Endocrinology, M.S. Ramaiah Medical College, Bengaluru, Karnataka, India.
authors.forename: K M
authors.initials: KM
authors.lastname: Suryanarayana
authors.affiliation: Department of Obstetrics and Gynaecology, M.S. Ramaiah Medical College, Bengaluru, Karnataka, India.
authors.forename: Ashwini
authors.initials: A
authors.lastname: Nayak
authors.affiliation: Department of Research and Patents, M.S. Ramaiah Medical College, Bengaluru, Karnataka, India.
authors.forename: N S
authors.initials: NS
authors.lastname: Murthy
authors.affiliation: Department of Endocrinology, M.S. Ramaiah Medical College, Bengaluru, Karnataka, India.
authors.forename: Mala
authors.initials: M
authors.lastname: Dharmalingam
authors.affiliation: Department of Endocrinology, M.S. Ramaiah Medical College, Bengaluru, Karnataka, India.
authors.forename: Pramila
authors.initials: P
authors.lastname: Kalra
keywords: Adiponectin; antenatal screening; gestational diabetes mellitus