title: Organogel-assisted topochemical synthesis of multivalent glyco-polymer for high-affinity lectin binding.
abstract: An organogelator, 2,4-undeca-diynyl-4',6'-O-benzylidene-β-d-galactopyranoside, which aligns its diacetylene upon gelation, has been synthesized. UV irradiation of its gel resulted in topochemical polymerization of the gelator forming polydiacetylene (PDA). We have used this gel-state reaction for the synthesis of surface-immobilized multi-valent glycoclusters, which showed 1000-fold enhanced binding, compared to monomers, with various galactose-binding lectins.
authors.affiliation: School of Chemistry, Indian Institute of Science Education and Research Thiruvananthapuram, Kerala 695016, India. kms@iisertvm.ac.in.
authors.forename: Baiju P
authors.initials: BP
authors.lastname: Krishnan
authors.affiliation: School of Chemistry, Indian Institute of Science Education and Research Thiruvananthapuram, Kerala 695016, India. kms@iisertvm.ac.in.
authors.forename: Sreedevi
authors.initials: S
authors.lastname: Raghu
authors.affiliation: School of Chemistry, Indian Institute of Science Education and Research Thiruvananthapuram, Kerala 695016, India. kms@iisertvm.ac.in.
authors.forename: Somnath
authors.initials: S
authors.lastname: Mukherjee
authors.affiliation: School of Chemistry, Indian Institute of Science Education and Research Thiruvananthapuram, Kerala 695016, India. kms@iisertvm.ac.in.
authors.forename: Kana M
authors.initials: KM
authors.lastname: Sureshan
mesh_terms: D001665:Binding Sites; D005690:Galactose / Q000138:chemical synthesis* / Q000737:chemistry; D005782:Gels / Q000737:chemistry; D037102:Lectins / Q000737:chemistry*; D015394:Molecular Structure; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D005782:Gels; D037102:Lectins; D011108:Polymers; D005690:Galactose