title: Oxidative Damage and Cytotoxicity of Perfluorooctane Sulfonate on Chlorella vulgaris.
abstract: We studied the effects of perfluorooctane sulfonate (PFOS) on the chlorophyll content, cell permeability, and antioxidant defense systems of the green alga Chlorella vulgaris. The results showed that the production of reactive oxygen species increased in a concentration-dependent manner after exposure to PFOS for 96 h. Superoxide dismutase and catalase activity was elevated after exposure to the lower concentrations and then decreased with higher concentrations. Malondialdehyde content was significantly higher than that of controls at the higher PFOS concentrations. Cell membrane permeability increased. These results indicate that PFOS exposure leads to oxidative damage in C. vulgaris. At these concentrations, chlorophyll and the structure of chloroplasts were destroyed.
authors.affiliation: College of Biology and Environmental Engineering, Zhejiang Shuren University, Hangzhou, 310015, China. dm25xu@163.com.
authors.forename: Dongmei
authors.initials: D
authors.lastname: Xu
authors.affiliation: College of Biology and Environmental Engineering, Zhejiang Shuren University, Hangzhou, 310015, China.
authors.forename: Xuesong
authors.initials: X
authors.lastname: Chen
authors.affiliation: College of Biology and Environmental Engineering, Zhejiang Shuren University, Hangzhou, 310015, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Shao
mesh_terms: D017738:Alkanesulfonic Acids / Q000633:toxicity*; D000975:Antioxidants / Q000378:metabolism; D002374:Catalase / Q000378:metabolism; D002463:Cell Membrane Permeability / Q000187:drug effects; D048408:Chlorella vulgaris / Q000187:drug effects* / Q000378:metabolism*; D002734:Chlorophyll / Q000378:metabolism; D005466:Fluorocarbons / Q000633:toxicity*; D008315:Malondialdehyde / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects*; D017382:Reactive Oxygen Species / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D017738:Alkanesulfonic Acids; D000975:Antioxidants; D005466:Fluorocarbons; D017382:Reactive Oxygen Species; D002734:Chlorophyll; D008315:Malondialdehyde; C076994:perfluorooctane sulfonic acid; D002374:Catalase; D013482:Superoxide Dismutase
keywords: Algae; Antioxidant defense systems; Cell permeability; Chlorophyll; PFOS