title: Targeted next generation sequencing of breast implant-associated anaplastic large cell lymphoma reveals mutations in JAK/STAT signalling pathway genes, TP53 and DNMT3A.
authors.affiliation: Department of Clinical and Molecular Medicine, Sant'Andrea Hospital, Sapienza University, Rome, Italy.
authors.forename: Arianna
authors.initials: A
authors.lastname: Di Napoli
authors.affiliation: Department of Pathology and Cell Biology, Columbia University Medical Center, New York Presbyterian Hospital, New York, NY, USA.
authors.forename: Preti
authors.initials: P
authors.lastname: Jain
authors.affiliation: Department of Clinical and Molecular Medicine, Sant'Andrea Hospital, Sapienza University, Rome, Italy.
authors.forename: Enrico
authors.initials: E
authors.lastname: Duranti
authors.affiliation: Department of Pathology and Cell Biology, Columbia University Medical Center, New York Presbyterian Hospital, New York, NY, USA.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Margolskee
authors.affiliation: Tumour Immunology Unit, Human Pathology Section, Department of Health Science, Palermo University, Palermo, Italy.
authors.forename: Walter
authors.initials: W
authors.lastname: Arancio
authors.affiliation: Pathology Section, Department of Molecular and Translational Medicine, University-Spedali Civili of Brescia, Spedali Civili di Brescia, Brescia, Italy.
authors.forename: Fabio
authors.initials: F
authors.lastname: Facchetti
authors.affiliation: Department of Pathology and Cell Biology, Columbia University Medical Center, New York Presbyterian Hospital, New York, NY, USA.
authors.forename: Bachir
authors.initials: B
authors.lastname: Alobeid
authors.affiliation: Plastic Surgery Unit, Sant'Andrea Hospital, Sapienza University, Rome, Italy.
authors.forename: Fabio
authors.initials: F
authors.lastname: Santanelli di Pompeo
authors.affiliation: Department of Pathology and Cell Biology, Columbia University Medical Center, New York Presbyterian Hospital, New York, NY, USA.
authors.forename: Mahesh
authors.initials: M
authors.lastname: Mansukhani
authors.affiliation: Department of Pathology and Cell Biology, Columbia University Medical Center, New York Presbyterian Hospital, New York, NY, USA.
authors.forename: Govind
authors.initials: G
authors.lastname: Bhagat
mesh_terms: D000368:Aged; D018427:Breast Implants / Q000009:adverse effects*; D004248:DNA (Cytosine-5-)-Methyltransferases / Q000235:genetics*; D000090205:DNA Methyltransferase 3A; D005260:Female; D016368:Frameshift Mutation / Q000235:genetics; D016158:Genes, p53 / Q000235:genetics*; D006801:Humans; D053612:Janus Kinases / Q000235:genetics; D017728:Lymphoma, Large-Cell, Anaplastic / Q000235:genetics*; D008875:Middle Aged; D009154:Mutation / Q000235:genetics*; D020125:Mutation, Missense / Q000235:genetics; D050796:STAT3 Transcription Factor / Q000235:genetics; D015398:Signal Transduction / Q000235:genetics; D000071222:Suppressor of Cytokine Signaling 1 Protein / Q000235:genetics
chemical_list: C000717967:DNMT3A protein, human; C108944:SOCS1 protein, human; D050796:STAT3 Transcription Factor; C494086:STAT3 protein, human; D000071222:Suppressor of Cytokine Signaling 1 Protein; D004248:DNA (Cytosine-5-)-Methyltransferases; D000090205:DNA Methyltransferase 3A; D053612:Janus Kinases
keywords: 
  DNMT3A
  ; 
  SOCS1
  ; 
  STAT3
  ; 
  TP53
  ; breast implant-associated anaplastic large-cell lymphoma; somatic mutations