title: Parkinson's disease and solvents: Is there a causal link?
abstract: We report here on chronic neurological impairment in three car painters with constant occupational exposure to organic solvents. All had a clinical presentation of Parkinson's disease and, in all cases, SPECT DaTscan brain imaging, using123I-FP-CIT, showed bilateral reduction of tracer uptake in the basal ganglia, evidence of dysfunction at the dopaminergic terminal.
authors.affiliation: Service de neurologie (Prof. Tranchant), CHU de Strasbourg, club de neurologie et environnement, 67200 Strasbourg, France. Electronic address: Jacques.reis@wanadoo.fr.
authors.forename: J
authors.initials: J
authors.lastname: Reis
authors.affiliation: Occupational medicine department, faculté de médecine et de pharmacie, université de Poitiers, CHU, 86073 Poitiers, France.
authors.forename: E
authors.initials: E
authors.lastname: Benbrick
authors.affiliation: Occupational diseases clinic, Grenoble teaching hospital, CHU de Grenoble, 38000 Grenoble, France.
authors.forename: V
authors.initials: V
authors.lastname: Bonneterre
authors.affiliation: School of medicine, Oregon institute of occupational health sciences, Oregon health & science university, Portland, Oregon, USA.
authors.forename: P S
authors.initials: PS
authors.lastname: Spencer
mesh_terms: D001479:Basal Ganglia / Q000000981:diagnostic imaging; D059290:Dopaminergic Neurons / Q000473:pathology; D006801:Humans; D008297:Male; D008397:Masks; D008875:Middle Aged; D009784:Occupational Diseases / Q000175:diagnosis* / Q000000981:diagnostic imaging*; D016273:Occupational Exposure / Q000009:adverse effects*; D010150:Paint / Q000009:adverse effects*; D010302:Parkinson Disease, Secondary / Q000139:chemically induced* / Q000000981:diagnostic imaging*; D019275:Radiopharmaceuticals; D012997:Solvents / Q000633:toxicity*; D015899:Tomography, Emission-Computed, Single-Photon; D014326:Tropanes; D014691:Ventilation
chemical_list: D019275:Radiopharmaceuticals; D012997:Solvents; D014326:Tropanes; C087552:2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane
keywords: DaTscan; Organic solvents; Painters; Parkinson's disease