title: Efficacy ofScutellaria baicalensisfor the Treatment of Hand, Foot, and Mouth Disease Associated with Encephalitis in Patients Infected with EV71: A Multicenter, Retrospective Analysis.
abstract: This study aimed to evaluate the clinical efficacy and safety of using the traditional Chinese herbal medicineScutellaria baicalensisfor the treatment of severe HFMD in 725 patients aged >1 year in a multicenter, retrospective analysis. The patients were divided into theS. baicalensisand ribavirin groups, and the temperatures, presence or absence of skin rashes and oral lesions, nervous system (NS) involvement, and viral loads of the patients, as well as the safety of the treatments, were evaluated. The median duration of fever, median time to NS involvement, and the number of patients with oral ulcers and/or vesicles, as well as skin rashes, were decreased in theS. baicalensisgroup compared with the ribavirin group. In addition, the EV71 viral loads were decreased in theS. baicalensisgroup, suggesting thatS. baicalensisexerted more potent antiviral effects compared with ribavirin. The present study demonstrated thatS. baicalensiswas suitable for the treatment of severe HFMD in patients aged >1 year, since it was shown to rapidly relieve fever, attenuate oral lesions and rashes, and improve NS involvement. Furthermore, it was demonstrated to be relatively safe for topical application.
authors.affiliation: Department of Pediatrics, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
authors.forename: Hailong
authors.initials: H
authors.lastname: Lin
authors.affiliation: Department of Pediatrics, The First People's Hospital of Yongkang, Jinhua, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Zhou
authors.affiliation: Department of Pediatrics, The First People's Hospital of Yongkang, Jinhua, China.
authors.forename: Kaichun
authors.initials: K
authors.lastname: Lin
authors.affiliation: Department of Pediatrics, The Affiliated Children's Hospital of Zhejiang University Medical College, Hangzhou, China.
authors.forename: Hongjiao
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Pediatrics, Hainan Provincial People's Hospital, Haikou, China.
authors.forename: Zunhong
authors.initials: Z
authors.lastname: Liang
authors.affiliation: Department of Pediatrics, Zouping People's Hospital, Binzhou, Shandong Province, China.
authors.forename: Xingshuai
authors.initials: X
authors.lastname: Ren
authors.affiliation: Department of Pediatrics, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
authors.forename: Leting
authors.initials: L
authors.lastname: Huang
authors.affiliation: Department of Pediatrics, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
authors.forename: Chan
authors.identifier: 0000-0002-1666-6339
authors.initials: C
authors.lastname: Xia
mesh_terms: D000998:Antiviral Agents / Q000008:administration & dosage; D002681:China; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage; D018792:Encephalitis, Viral / Q000175:diagnosis / Q000188:drug therapy* / Q000821:virology; D029821:Enterovirus A, Human; D004769:Enterovirus Infections / Q000175:diagnosis / Q000188:drug therapy* / Q000821:virology; D005260:Female; D006232:Hand, Foot and Mouth Disease / Q000175:diagnosis / Q000188:drug therapy* / Q000821:virology*; D006801:Humans; D007223:Infant; D008297:Male; D010936:Plant Extracts / Q000008:administration & dosage*; D012189:Retrospective Studies; D012254:Ribavirin / Q000008:administration & dosage; D031364:Scutellaria baicalensis / Q000737:chemistry; D016896:Treatment Outcome
chemical_list: D000998:Antiviral Agents; D004365:Drugs, Chinese Herbal; D010936:Plant Extracts; C499814:Scutellaria baicalensis extract; D012254:Ribavirin