title: Accelerated ferumoxytol-enhanced 4D multiphase, steady-state imaging with contrast enhancement (MUSIC) cardiovascular MRI: validation in pediatric congenital heart disease.
abstract: The purpose of this work was to validate a parallel imaging (PI) and compressed sensing (CS) combined reconstruction method for a recently proposed 4D non-breath-held, multiphase, steady-state imaging technique (MUSIC) cardiovascular MRI in a cohort of pediatric congenital heart disease patients. We implemented a graphics processing unit accelerated CS-PI combined reconstruction method and applied it in 13 pediatric patients who underwent cardiovascular MRI after ferumoxytol administration. Conventional breath-held contrast-enhanced magnetic resonance angiography (CE-MRA) was first performed during the first pass of ferumoxytol injection, followed by the original MUSIC and the proposed CS-PI MUSIC during the steady-state distribution phase of ferumoxytol. Qualities of acquired images were then evaluated using a four-point scale. Left ventricular volumes and ejection fractions calculated from the original MUSIC and the CS-PI MUSIC were also compared with conventional multi-slice 2D cardiac cine MRI. The proposed CS-PI MUSIC reduced the imaging time of the MUSIC acquisition to 4.6 ± 0.4 min from 8.9 ± 1.2 min. Computationally intensive image reconstruction was completed within 5 min without interruption of sequential clinical scans. The proposed method (mean 3.3-4.0) provided image quality comparable to that of the original MUSIC (3.2-4.0) (all P ≥ 0.42), and better than conventional breath-held first-pass CE-MRA (1.1-3.3) for 13 anatomical structures (all P ≤ 0.0014) with good inter-observer agreement (κ > 0.46). The calculated ventricular volumes and ejection fractions from both original MUSIC (r > 0.90) and CS-PI MUSIC (r > 0.85) correlated well with 2D cine imaging. In conclusion, PI and CS were successfully incorporated into the 4D MUSIC acquisition to further reduce scan time by approximately 50% while maintaining highly comparable image quality in a clinically practical reconstruction time.
authors.affiliation: Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, California, USA.|Department of Bioengineering, University of California, Los Angeles, California, USA.
authors.forename: Ziwu
authors.initials: Z
authors.lastname: Zhou
authors.affiliation: Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, California, USA.|Department of Bioengineering, University of California, Los Angeles, California, USA.
authors.forename: Fei
authors.initials: F
authors.lastname: Han
authors.affiliation: Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, California, USA.
authors.forename: Stanislas
authors.initials: S
authors.lastname: Rapacchi
authors.affiliation: Department of Medicine, Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, California, USA.|Division of Cardiology, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California, USA.
authors.forename: Kim-Lien
authors.initials: KL
authors.lastname: Nguyen
authors.affiliation: Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, California, USA.
authors.forename: Daniel Z
authors.initials: DZ
authors.lastname: Brunengraber
authors.affiliation: Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, California, USA.
authors.forename: Grace-Hyun J
authors.initials: GJ
authors.lastname: Kim
authors.affiliation: Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, California, USA.|Biomedical Physics Inter-Departmental Graduate Program, University of California, Los Angeles, California, USA.
authors.forename: J Paul
authors.initials: JP
authors.lastname: Finn
authors.affiliation: Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, California, USA.|Department of Bioengineering, University of California, Los Angeles, California, USA.|Biomedical Physics Inter-Departmental Graduate Program, University of California, Los Angeles, California, USA.
authors.forename: Peng
authors.initials: P
authors.lastname: Hu
mesh_terms: D000293:Adolescent; D000465:Algorithms; D016477:Artifacts; D055424:Cardiac-Gated Imaging Techniques / Q000379:methods*; D002648:Child; D003287:Contrast Media; D005260:Female; D052203:Ferrosoferric Oxide; D006330:Heart Defects, Congenital / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D021621:Imaging, Three-Dimensional / Q000379:methods*; D007223:Infant; D007231:Infant, Newborn; D019028:Magnetic Resonance Imaging, Cine / Q000379:methods*; D008297:Male; D015203:Reproducibility of Results; D055425:Respiratory-Gated Imaging Techniques / Q000379:methods*; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media; D052203:Ferrosoferric Oxide
keywords: cardiac cine; compressed sensing; ferumoxytol; magnetic resonance angiography; parallel imaging; pediatric MRI