title: Interleukins 17 and 23 in patients with gastric neoplasms.
abstract: Recently there has been heightened interest in the potential significance of interleukin (IL)-17 and IL-23 in the development/progression of human malignancies. Here, we analyzed the systemic levels of these cytokines in 75 patients with different types of gastric neoplasms (carcinoma, gastrointestinal stromal tumors, neuroendocrine neoplasms, and lymphomas) and 42 healthy volunteers. We found that patients with all types of gastric neoplasms have significantly lower IL-23 levels. However, in comparison to the levels in healthy individuals, IL-17 concentrations were lower only in patients with types of gastric neoplasms other than carcinoma. Interestingly, IL-17 levels significantly differed between patients with early and advanced gastric carcinoma. No significant associations were detected between the systemic levels of examined interleukins and TNM staging. However, peripheral levels of IL-23 were correlated with the absolute numbers of circulating populations of bone marrow-derived mesenchymal and very small embryonic/epiblast-like stem cells in patients with gastric carcinoma. ROC curve analyses demonstrated that systemic levels of IL-17 seem to meet basic criteria for consideration as a helpful diagnostic marker in the detection of gastric carcinoma. In conclusion, our study provides translational evidence confirming the clinical significance of IL-17 and IL-23 in the pathogenesis of different types of gastric neoplasms in humans.
authors.affiliation: Department of Internal Medicine, University of Zielona Gora, Zielona Gora, Poland.
authors.forename: Wojciech
authors.initials: W
authors.lastname: Błogowski
authors.affiliation: Department of Gastroenterology, Pomeranian Medical University, Szczecin, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Madej-Michniewicz
authors.affiliation: Department of Microbiology, Immunology and Laboratory Medicine, Pomeranian Medical University, Szczecin, Poland.
authors.forename: Natalia
authors.initials: N
authors.lastname: Marczuk
authors.affiliation: Department of Microbiology, Immunology and Laboratory Medicine, Pomeranian Medical University, Szczecin, Poland.
authors.forename: Barbara
authors.initials: B
authors.lastname: Dołęgowska
authors.affiliation: Department of Gastroenterology, Pomeranian Medical University, Szczecin, Poland.
authors.forename: Teresa
authors.initials: T
authors.lastname: Starzyńska
mesh_terms: D000368:Aged; D001854:Bone Marrow Cells / Q000473:pathology; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D020381:Interleukin-17 / Q000097:blood*; D053760:Interleukin-23 Subunit p19 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D012372:ROC Curve; D013234:Stem Cells / Q000378:metabolism / Q000473:pathology; D013274:Stomach Neoplasms / Q000097:blood* / Q000175:diagnosis / Q000473:pathology
chemical_list: C508717:IL17A protein, human; C508840:IL23A protein, human; D020381:Interleukin-17; D053760:Interleukin-23 Subunit p19