title: Mother-To-Child Transmission of KPC Carbapenemase-Producing Klebsiella Pneumoniae at Birth.
abstract: We report on a mother-to-child transmission of KPC carbapenemase-producing Klebsiella pneumoniae at birth followed by subsequent cases in the neonatal intensive care unit. Molecular analysis of isolates showed production of KPC-3 enzyme. The only potential risk factor identified for the mother was previous activity as a caregiver. Present findings suggest consideration of proactive surveillance in pregnant women with risk factors for colonization.
authors.affiliation: From the *Infectious Diseases Unit, †Neonatal Intensive Care Unit, and ‡Microbiology and Virology, A. Manzoni Hospital, Lecco, Italy; §Department of Medical Biotechnologies, University of Siena, Siena, Italy; and ¶Department of Experimental and Clinical Medicine, University of Florence, ‖Clinical Microbiology, Virology and Serology Unit, Florence Careggi University Hospital, and **Don Carlo Gnocchi Foundation, Florence, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Bonfanti
authors.forename: Roberto
authors.initials: R
authors.lastname: Bellù
authors.forename: Luigi
authors.initials: L
authors.lastname: Principe
authors.forename: Ilaria
authors.initials: I
authors.lastname: Caramma
authors.forename: Manuela
authors.initials: M
authors.lastname: Condò
authors.forename: Tommaso
authors.initials: T
authors.lastname: Giani
authors.forename: Gian Maria
authors.initials: GM
authors.lastname: Rossolini
authors.forename: Francesco
authors.initials: F
authors.lastname: Luzzaro
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use; D001426:Bacterial Proteins; D015780:Carbapenems; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D007710:Klebsiella Infections / Q000382:microbiology / Q000635:transmission; D007711:Klebsiella pneumoniae / Q000187:drug effects / Q000201:enzymology / Q000302:isolation & purification; D008826:Microbial Sensitivity Tests; D011247:Pregnancy; D018440:beta-Lactam Resistance; D001618:beta-Lactamases
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D015780:Carbapenems; D001618:beta-Lactamases; C063912:carbapenemase