title: Imatinib-induced pleural effusion: A case report.
abstract: Imatinib is a tyrosine kinase inhibitor and has rarely been reported to cause pleural effusion. We report the case of an 88-year-old male, known case of gastrointestinal stromal tumor on treatment with imatinib, who presented with a 2-week history of cough and dyspnea. He was diagnosed to have a right-sided pleural effusion and thoracentesis of the fluid revealed an exudate with low adenosine deaminase and negative cytology. Withdrawal of the drug lead to resolution of symptoms. We report this case to highlight the side effect profile of imatinib and warn physicians regarding this potential adverse effect which may be mistaken for metastasis or infection.
authors.affiliation: Department of Pulmonary Medicine, P. D. Hinduja National Hospital and Medical Research Centre, Mumbai, Maharashtra, India.
authors.forename: R
authors.initials: R
authors.lastname: Banka
authors.affiliation: Department of Pulmonary Medicine, P. D. Hinduja National Hospital and Medical Research Centre, Mumbai, Maharashtra, India.
authors.forename: Z
authors.initials: Z
authors.lastname: Udwadia
mesh_terms: D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D003371:Cough / Q000209:etiology; D004417:Dyspnea / Q000209:etiology; D005770:Gastrointestinal Neoplasms / Q000188:drug therapy / Q000473:pathology; D046152:Gastrointestinal Stromal Tumors / Q000188:drug therapy*; D006801:Humans; D000068877:Imatinib Mesylate / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D010996:Pleural Effusion / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000601:surgery; D000069258:Thoracentesis; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D000068877:Imatinib Mesylate