title: [Polymorphism in HLA and KIR genes and the impact on hematopoietic stem cell transplantation outcomes and unrelated donor selection: Guidelines from the Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC)].
abstract: In an attempt to harmonize clinical practices among French hematopoietic stem cell transplantation centers, the Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC) held its sixth annual workshop series in September 2015 in Lille. This event brought together practitioners from across the country with the purpose of offering careful analysis of published studies on clinical practice issues that remain to be disputed. This article addresses the impact of HLA and KIR gene polymorphism on the outcome of the transplantation in order to optimize unrelated donor selection.
authors.affiliation: EFS Rhône Alpes, laboratoire HLA, 1 et 3, rue du Vercors, 69007 Lyon, France.
authors.forename: Valérie
authors.initials: V
authors.lastname: Dubois
authors.affiliation: AP-HP, hôpital Saint-Louis, Aphérèse thérapeutique, 1, rue Claude-Vellefaux, 75010 Paris, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Brignier
authors.affiliation: CHU de Lille, laboratoire HLA, boulevard Pr-Jules-Leclerc, 59037 Lille cedex, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Elsermans
authors.affiliation: EFS Pays de la Loire, laboratoire HLA et EA4271, 34, boulevard Jean-Monnet, 44011 Nantes, France.
authors.forename: Katia
authors.initials: K
authors.lastname: Gagne
authors.affiliation: CHU de Nancy Brabois, laboratoire HLA, rue du Morvan, 54500 Vandoeuvre-les-Nancy, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Kennel
authors.affiliation: Hôpital Robert-Debré, laboratoire d'immunologie, 48, boulevard Serurier, 75019 Paris, France.
authors.forename: Béatrice
authors.initials: B
authors.lastname: Pedron
authors.affiliation: EFS Alpes-Méditerranée, laboratoire HLA, 149, boulevard Baille, 13005 Marseille, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Picard
authors.affiliation: CHU Estaing, hématologie clinique et thérapie cellulaire, 58, rue Montalembert, 63000 Clermont-Ferrand, France.
authors.forename: Aurélie
authors.initials: A
authors.lastname: Ravinet
authors.affiliation: CHU de Lille, laboratoire HLA, boulevard Pr-Jules-Leclerc, 59037 Lille cedex, France.
authors.forename: Pauline
authors.initials: P
authors.lastname: Varlet
authors.affiliation: EFS Pays de la Loire, laboratoire HLA et EA4271, 34, boulevard Jean-Monnet, 44011 Nantes, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Cesbron
authors.affiliation: EFS Île-de-France, laboratoire HLA ILP, 1, voie Felix-Eboue, 94010 Créteil, France.
authors.forename: Florent
authors.initials: F
authors.lastname: Delbos
authors.affiliation: CHU de Lille, université Lille 2, LIRIC Inserm U995, 59000 Lille, France. Electronic address: sfgm-tc@orange.fr.
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Yakoub-Agha
authors.affiliation: AP-HP, hôpital Saint-Louis, laboratoire Jean-Dausset, 1, rue Claude-Vellefaux, 75010 Paris, France.
authors.forename: Pascale
authors.initials: P
authors.lastname: Loiseau
mesh_terms: D000483:Alleles; D046148:Donor Selection / Q000592:standards*; D005602:France; D005838:Genotype; D018380:Hematopoietic Stem Cell Transplantation; D006648:Histocompatibility / Q000235:genetics* / Q000276:immunology; D006649:Histocompatibility Antigens / Q000235:genetics* / Q000276:immunology; D006801:Humans; D011110:Polymorphism, Genetic; D054340:Receptors, KIR / Q000235:genetics* / Q000276:immunology; D012955:Societies, Medical; D016896:Treatment Outcome
chemical_list: D006649:Histocompatibility Antigens; D054340:Receptors, KIR
keywords: Greffe de CSH; Gènes HLA; Gènes KIR; HLA genes; HSCT; Incompatibilités permissives/non permissives; KIR genes; Overall survival; Permissive/non permissive incompatibilities; Survie globale