title: Efficacy and Safety of Percutaneous Coronary Intervention for Elderly Patients in the Second-Generation Drug-Eluting Stent Era: The SHINANO Registry.
abstract: BACKGROUND
  We evaluated the 1-year outcomes of percutaneous coronary intervention (PCI) for elderly patients (aged ≥ 80 years) in the second-generation drug-eluting stent (DES) era.
  
  
  RESULTS
  Between August 2012 and July 2013, 1923 consecutive patients (mean age, 71 ± 11 years; ≥80 years, 23%; men, 77%) who underwent 2250 elective/urgent PCI procedures were enrolled in the Shinshu Prospective Multicenter Analysis for Elderly Patients with Coronary Artery Disease Undergoing Percutaneous Coronary Intervention registry. The primary end point was major adverse cardiovascular events (MACEs; cardiovascular death, myocardial infarction, and stroke) at 1 year. The 1-year incidence of MACEs, cardiac death, and stroke was significantly higher in elderly patients than in nonelderly patients (12.4% vs 5.3%, P < .0001; 7.8% vs 2.2%, P < .0001; and 2.8% vs 1.3%, P = .033, respectively). However, no significant difference in elective PCI procedures was detected. In elderly patients, the incidence of cardiac death and target lesion revascularization was significantly lower for DES than for non-DES (2.7% vs 10.5%, P = .0001 and 4.1% vs 8.6%, P = .029, respectively).
  
  
  CONCLUSIONS
  Although elderly patients had a significantly poorer prognosis than younger patients, the adverse events rate was comparable in those patients who underwent elective PCI in the second-generation DES era.
authors.affiliation: 1 Department of Cardiovascular Medicine, Shinshu University School of Medicine, Matsumoto, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Miura
authors.affiliation: 1 Department of Cardiovascular Medicine, Shinshu University School of Medicine, Matsumoto, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Miyashita
authors.affiliation: 1 Department of Cardiovascular Medicine, Shinshu University School of Medicine, Matsumoto, Japan.
authors.forename: Hirohiko
authors.initials: H
authors.lastname: Motoki
authors.affiliation: 2 Department of Cardiology, Shinshu Ueda Medical Center, Ueda, Japan.
authors.forename: Hideki
authors.initials: H
authors.lastname: Kobayashi
authors.affiliation: 3 Department of Cardiology, Matsumoto Kyoritsu Hospital, Matsumoto, Japan.
authors.forename: Masanori
authors.initials: M
authors.lastname: Kobayashi
authors.affiliation: 4 Department of Cardiology, Nagano Matsushiro General Hospital, Nagano, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Nakajima
authors.affiliation: 5 Department of Cardiology, Saku Central Hospital, Saku, Japan.
authors.forename: Hikaru
authors.initials: H
authors.lastname: Kimura
authors.affiliation: 6 Department of Cardiology, Iida Municipal Hospital, Iida, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Akanuma
authors.affiliation: 7 Department of Cardiology, Kita Alps Medical Center, Azumino, Japan.
authors.forename: Eiichiro
authors.initials: E
authors.lastname: Mawatari
authors.affiliation: 8 Department of Cardiology, Shinonoi General Hospital, Nagano, Japan.
authors.forename: Toshio
authors.initials: T
authors.lastname: Sato
authors.affiliation: 9 Department of Cardiology, Ina Central Hospital, Ina, Japan.
authors.forename: Shoji
authors.initials: S
authors.lastname: Hotta
authors.affiliation: 10 Department of Cardiology, Aizawa Hospital, Matsumoto, Japan.
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Kamiyoshi
authors.affiliation: 8 Department of Cardiology, Shinonoi General Hospital, Nagano, Japan.
authors.forename: Takuya
authors.initials: T
authors.lastname: Maruyama
authors.affiliation: 11 Department of Cardiology, Hokushin General Hospital, Nakano, Japan.
authors.forename: Noboru
authors.initials: N
authors.lastname: Watanabe
authors.affiliation: 12 Department of Cardiology, Komoro Kosei General Hospital, Komoro, Japan.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Eisawa
authors.affiliation: 10 Department of Cardiology, Aizawa Hospital, Matsumoto, Japan.
authors.forename: Shinichi
authors.initials: S
authors.lastname: Aso
authors.affiliation: 8 Department of Cardiology, Shinonoi General Hospital, Nagano, Japan.
authors.forename: Naoto
authors.initials: N
authors.lastname: Hashizume
authors.affiliation: 1 Department of Cardiovascular Medicine, Shinshu University School of Medicine, Matsumoto, Japan.
authors.forename: Soichiro
authors.initials: S
authors.lastname: Ebisawa
authors.affiliation: 1 Department of Cardiovascular Medicine, Shinshu University School of Medicine, Matsumoto, Japan.
authors.forename: Uichi
authors.initials: U
authors.lastname: Ikeda
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003131:Combined Modality Therapy; D003324:Coronary Artery Disease / Q000188:drug therapy* / Q000601:surgery*; D054855:Drug-Eluting Stents; D023381:Endpoint Determination; D005260:Female; D006801:Humans; D007564:Japan; D008297:Male; D061214:Patient Safety; D062645:Percutaneous Coronary Intervention; D011379:Prognosis; D011446:Prospective Studies; D012042:Registries; D016896:Treatment Outcome
keywords: coronary artery disease; elderly; percutaneous coronary intervention