title: Systems Approaches to Cancer Biology.
abstract: Cancer systems biology aims to understand cancer as an integrated system of genes, proteins, networks, and interactions rather than an entity of isolated molecular and cellular components. The inaugural Systems Approaches to Cancer Biology Conference, cosponsored by the Association of Early Career Cancer Systems Biologists and the National Cancer Institute of the NIH, focused on the interdisciplinary field of cancer systems biology and the challenging cancer questions that are best addressed through the combination of experimental and computational analyses. Attendees found that elucidating the many molecular features of cancer inevitably reveals new forms of complexity and concluded that ensuring the reproducibility and impact of cancer systems biology studies will require widespread method and data sharing and, ultimately, the translation of important findings to the clinic. Cancer Res; 76(23); 6774-7. ©2016 AACR.
authors.affiliation: Department of Neurology, Boston Children's Hospital, Boston, Massachusetts.
authors.forename: Tenley C
authors.initials: TC
authors.lastname: Archer
authors.affiliation: Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland.
authors.forename: Elana J
authors.initials: EJ
authors.lastname: Fertig
authors.affiliation: Sage Bionetworks, Seattle, Washington.
authors.forename: Sara J C
authors.initials: SJ
authors.lastname: Gosline
authors.affiliation: Department of Systems Biology, Harvard Medical School, Boston, Massachusetts.
authors.forename: Marc
authors.initials: M
authors.lastname: Hafner
authors.affiliation: Division of Cancer Biology, National Cancer Institute of the NIH, Rockville, Maryland.
authors.forename: Shannon K
authors.initials: SK
authors.lastname: Hughes
authors.affiliation: Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts.
authors.forename: Brian A
authors.initials: BA
authors.lastname: Joughin
authors.affiliation: Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts. ameyer@asmlab.org.
authors.forename: Aaron S
authors.initials: AS
authors.lastname: Meyer
authors.affiliation: Department of Biology, Brigham Young University, Provo, Utah.
authors.forename: Stephen R
authors.initials: SR
authors.lastname: Piccolo
authors.affiliation: Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, District of Columbia.
authors.forename: Ayesha N
authors.initials: AN
authors.lastname: Shajahan-Haq
mesh_terms: D006801:Humans; D009369:Neoplasms; D049490:Systems Biology / Q000379:methods*