title: Positive predictive value of cardiovascular diagnoses in the Danish National Patient Registry: a validation study.
abstract: The majority of cardiovascular diagnoses in the Danish National Patient Registry (DNPR) remain to be validated despite extensive use in epidemiological research. We therefore examined the positive predictive value (PPV) of cardiovascular diagnoses in the DNPR.
  
  
  
  Population-based validation study.
  
  
  
  1 university hospital and 2 regional hospitals in the Central Denmark Region, 2010-2012.
  
  
  
  For each cardiovascular diagnosis, up to 100 patients from participating hospitals were randomly sampled during the study period using the DNPR.
  
  
  
  Using medical record review as the reference standard, we examined the PPV for cardiovascular diagnoses in the DNPR, coded according to the International Classification of Diseases, 10th Revision.
  
  
  
  A total of 2153 medical records (97% of the total sample) were available for review. The PPVs ranged from 64% to 100%, with a mean PPV of 88%. The PPVs were ≥90% for first-time myocardial infarction, stent thrombosis, stable angina pectoris, hypertrophic cardiomyopathy, arrhythmogenic right ventricular cardiomyopathy, takotsubo cardiomyopathy, arterial hypertension, atrial fibrillation or flutter, cardiac arrest, mitral valve regurgitation or stenosis, aortic valve regurgitation or stenosis, pericarditis, hypercholesterolaemia, aortic dissection, aortic aneurysm/dilation and arterial claudication. The PPVs were between 80% and 90% for recurrent myocardial infarction, first-time unstable angina pectoris, pulmonary hypertension, bradycardia, ventricular tachycardia/fibrillation, endocarditis, cardiac tumours, first-time venous thromboembolism and between 70% and 80% for first-time and recurrent admission due to heart failure, first-time dilated cardiomyopathy, restrictive cardiomyopathy and recurrent venous thromboembolism. The PPV for first-time myocarditis was 64%. The PPVs were consistent within age, sex, calendar year and hospital categories.
  
  
  
  The validity of cardiovascular diagnoses in the DNPR is overall high and sufficient for use in research since 2010.
authors.affiliation: Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus N, Denmark.|Department of Cardiology, Aarhus University Hospital, Skejby, Aarhus N, Denmark.
authors.forename: Jens
authors.initials: J
authors.lastname: Sundbøll
authors.affiliation: Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus N, Denmark.|Department of Cardiology, Aarhus University Hospital, Skejby, Aarhus N, Denmark.
authors.forename: Kasper
authors.initials: K
authors.lastname: Adelborg
authors.affiliation: Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus N, Denmark.
authors.forename: Troels
authors.initials: T
authors.lastname: Munch
authors.affiliation: Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus N, Denmark.
authors.forename: Trine
authors.initials: T
authors.lastname: Frøslev
authors.affiliation: Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus N, Denmark.
authors.forename: Henrik Toft
authors.initials: HT
authors.lastname: Sørensen
authors.affiliation: Department of Cardiology, Aarhus University Hospital, Skejby, Aarhus N, Denmark.
authors.forename: Hans Erik
authors.initials: HE
authors.lastname: Bøtker
authors.affiliation: Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus N, Denmark.|Department of Internal Medicine, Regional Hospital of Randers, Randers, Denmark.
authors.forename: Morten
authors.initials: M
authors.lastname: Schmidt
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002318:Cardiovascular Diseases / Q000145:classification* / Q000175:diagnosis* / Q000453:epidemiology; D003718:Denmark / Q000453:epidemiology; D005260:Female; D006801:Humans; D038801:International Classification of Diseases; D008297:Male; D008499:Medical Records / Q000706:statistics & numerical data*; D008875:Middle Aged; D011237:Predictive Value of Tests; D012042:Registries
keywords: CARDIOLOGY; EPIDEMIOLOGY