title: Different brain responses to electro-acupuncture and moxibustion treatment in patients with Crohn's disease.
abstract: This study aimed to investigate changes in resting state brain activity in remissive Crohn's Disease (CD) patients after electro-acupuncture or moxibustion treatment. Fifty-two CD patients and 36 healthy subjects were enrolled, and 36 patients were equally and randomly assigned to receive either electro-acupuncture or moxibustion treatment for twelve weeks. We used resting state functional magnetic resonance imaging to assess Regional Homogeneity (ReHo) levels, and Crohn's Disease Activity Index (CDAI) and Inflammatory Bowel Disease Questionnaire (IBDQ) scores to evaluate disease severity and quality of life. The results show that (i) The ReHo levels in CD patients were significantly increased in cortical but decreased in subcortical areas, and the coupling between them was declined. (ii) Both treatments decreased CDAI, increased IBDQ scores, and normalized the ReHo values of the cortical and subcortical regions. (iii) ReHo changes in multiple cortical regions were significantly correlated with CDAI score decreases. ReHo changes in several subcortical regions in the electro-acupuncture group, and those of several cortical regions in the moxibustion group, were correlated with reduced CDAI. These findings suggest that both treatments improved cortex-subcortical coupling in remissive CD patients, but electro-acupuncture regulated homeostatic afferent processing network, while moxibustion mainly regulated the default mode network of the brain.
authors.affiliation: Key Laboratory of Acupuncture and Immunological Effects, Shanghai University of Traditional Chinese Medicine, Shanghai, 200030, China.
authors.forename: Chunhui
authors.initials: C
authors.lastname: Bao
authors.affiliation: Life Sciences Research Center, School of Life Sciences and Technology, Xidian University, Xi'an, Shaanxi, 710071, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Liu
authors.affiliation: Outpatient Department, Shanghai Research Institute of Acupuncture and Meridian, Shanghai University of Traditional Chinese Medicine, Shanghai, 200030, China.
authors.forename: Huirong
authors.initials: H
authors.lastname: Liu
authors.affiliation: Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana, 46202, USA.
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Jin
authors.affiliation: The Mind Research Network, Albuquerque, NM, 87131, USA.|Department of Electrical and Computer Engineering, University of New Mexico, Albuquerque, NM, 87131, USA.
authors.forename: Vince D
authors.initials: VD
authors.lastname: Calhoun
authors.affiliation: Key Laboratory of Acupuncture and Immunological Effects, Shanghai University of Traditional Chinese Medicine, Shanghai, 200030, China.
authors.forename: Luyi
authors.initials: L
authors.lastname: Wu
authors.affiliation: Outpatient Department, Shanghai Research Institute of Acupuncture and Meridian, Shanghai University of Traditional Chinese Medicine, Shanghai, 200030, China.
authors.forename: Yin
authors.initials: Y
authors.lastname: Shi
authors.affiliation: Department of Radiology, Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai, 200030, China.
authors.forename: Jianye
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Gastroenterology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
authors.forename: Xiaoqing
authors.initials: X
authors.lastname: Zeng
authors.affiliation: Endoscopy Center, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
authors.forename: Lili
authors.initials: L
authors.lastname: Ma
authors.affiliation: Life Sciences Research Center, School of Life Sciences and Technology, Xidian University, Xi'an, Shaanxi, 710071, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Qin
authors.affiliation: Key Laboratory of Acupuncture and Immunological Effects, Shanghai University of Traditional Chinese Medicine, Shanghai, 200030, China.
authors.forename: Jingzhi
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Life Sciences Research Center, School of Life Sciences and Technology, Xidian University, Xi'an, Shaanxi, 710071, China.
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Liu
authors.affiliation: Life Sciences Research Center, School of Life Sciences and Technology, Xidian University, Xi'an, Shaanxi, 710071, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Tian
authors.affiliation: Key Laboratory of Acupuncture and Immunological Effects, Shanghai University of Traditional Chinese Medicine, Shanghai, 200030, China.
authors.forename: Huangan
authors.initials: H
authors.lastname: Wu
mesh_terms: D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging / Q000503:physiopathology*; D016022:Case-Control Studies; D003424:Crohn Disease / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy*; D015671:Electroacupuncture; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009071:Moxibustion; D055815:Young Adult