title: Screening for Pancreatic Cancer.
abstract: Pancreatic cancer (PC) is a highly fatal disease that can only be cured by complete surgical resection. However, most patients with PC have unresectable disease at the time of diagnosis, highlighting the need to detect PC and its precursor lesions earlier in asymptomatic patients. Screening is not cost-effective for population-based screening of PC. Individuals with genetic risk factors for PC based on family history or known PC-associated genetic syndromes, however, can be a potential target for PC screening programs. This article provides an overview of the epidemiology and genetic background of familial PC and discusses diagnostic and management approaches.
authors.affiliation: Division of Gastroenterology and Hepatology, Johns Hopkins Hospital, Johns Hopkins Medical Institutions, Blalock 407, Baltimore, MD 21287, USA.
authors.forename: Saowanee
authors.initials: S
authors.lastname: Ngamruengphong
authors.affiliation: Division of Gastroenterology and Hepatology, Johns Hopkins Hospital, Johns Hopkins Medical Institutions, Blalock 407, Baltimore, MD 21287, USA. Electronic address: mcanto1@jhmi.edu.
authors.forename: Marcia Irene
authors.initials: MI
authors.lastname: Canto
mesh_terms: D055088:Early Detection of Cancer / Q000379:methods*; D014943:Global Health; D006801:Humans; D009017:Morbidity / Q000639:trends; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000453:epidemiology*
keywords: Familial pancreatic cancer; Intraductal papillary mucinous neoplasm; Pancreatic cancer; Pancreatic cyst; Pancreatic intraepithelial neoplasia; Screening