title: Temporal regulation of autophagy response by the CULLIN 4-AMBRA1-CULLIN 5 axis.
abstract: Autophagy controls cell homeostasis and provides a rapid response to a variety of stresses. Although many steps of the autophagy process have been elucidated, how they are temporally regulated is less well characterized. Recently, we reported that dynamic interaction of the pro-autophagic factor AMBRA1 with CULLIN E3 ubiquitin ligases ensures the timely onset and termination of the autophagy response.
authors.affiliation: National Institute for Infectious Diseases 'L. Spallanzani' IRCCS; Rome, Italy; Department of Biology; University of Rome 'Tor Vergata'; Rome, Italy.
authors.forename: Manuela
authors.initials: M
authors.lastname: Antonioli
authors.affiliation: National Institute for Infectious Diseases 'L. Spallanzani' IRCCS ; Rome, Italy.
authors.forename: Federica
authors.initials: F
authors.lastname: Albiero
authors.affiliation: National Institute for Infectious Diseases 'L. Spallanzani' IRCCS; Rome, Italy; Department of Biology; University of Rome 'Tor Vergata'; Rome, Italy.
authors.forename: Mauro
authors.initials: M
authors.lastname: Piacentini
authors.affiliation: National Institute for Infectious Diseases 'L. Spallanzani' IRCCS; Rome, Italy; Department of Biological and Environmental Sciences and Technologies; University of Salento; Lecce, Italy.
authors.forename: Gian Maria
authors.initials: GM
authors.lastname: Fimia
keywords: AMBRA1; DDB1; DEPTOR; ELONGIN B; autophagy; ubiquitin proteasome system