title: Quantitative Evaluation of Normal Aqueductal Cerebrospinal Fluid Flow Using Phase-Contrast Cine MRI According to Age and Sex.
abstract: The aim of this study was cerebrospinal fluid (CSF) flow quantification in the cerebral aqueduct using phase-contrast cine magnetic resonance ımaging (PCC-MRI) according to both sexes and three different age groups to obtain normative data. Seventy two volunteers with no cerebral pathology were included in this study. Subjects were divided into three age groups: 20-34 years, 35-49 years, and 50-65 years including equal gender groups. CSF flow's quantitatively evaluation was performed with images that were obtained by 1.5 T Magnetic Resonance (MR) unit from cerebral aqueduct level on the semi-axial plan. Between groups, peak velocity (cm sec-1), average velocity (cm/s), forward volume (mL), reverse volume (mL), net forward volume (mL), and average flow over range (ml/min) values of current flowing through aqueduct and average aqueductal areas were compared. There were no statistically significant differences in CSF flow parameters among different age groups and between sexes (P > 0.05). There was a statistically significant difference in average cerebral aqueduct area between the age group of 50-65 years and the other age groups (P = 0.002). The average aqueductal area was higher in the age group of 50-65 years. Normal aqueductal CSF flow parameters evaluated with PCC-MRI don't show a significant difference by age and sex. We have achieved the lower and upper values of these parameters would be useful in future clinical studies. The size of aqueductal area may also be explained by atrophy-dependent ventricular system dilatation in the elderly. Anat Rec, 300:549-555, 2017. © 2016 Wiley Periodicals, Inc.
authors.affiliation: Department of Anatomy, Karabük University, Karabük, Turkey.
authors.forename: Zulal
authors.initials: Z
authors.lastname: Oner
authors.affiliation: Department of Radiology, İnönü University, Malatya, Turkey.
authors.forename: Aysegul
authors.initials: A
authors.lastname: Sagіr Kahraman
authors.affiliation: Department of Anatomy, İnönü University, Malatya, Turkey.
authors.forename: Evren
authors.initials: E
authors.lastname: Kose
authors.affiliation: Department of Radiology, Karabük University, Karabük, Turkey.
authors.forename: Serkan
authors.initials: S
authors.lastname: Oner
authors.affiliation: Department of Anatomy, Fırat University, Elazığ, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Kavaklі
authors.affiliation: Department of Anatomy, İnönü University, Malatya, Turkey.
authors.forename: Mahmut
authors.initials: M
authors.lastname: Cay
authors.affiliation: Department of Anatomy, İnönü University, Malatya, Turkey.
authors.forename: Davut
authors.initials: D
authors.lastname: Ozbag
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D002535:Cerebral Aqueduct / Q000000981:diagnostic imaging*; D002555:Cerebrospinal Fluid / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D019028:Magnetic Resonance Imaging, Cine / Q000379:methods; D008297:Male; D008875:Middle Aged; D012737:Sex Factors; D055815:Young Adult
keywords: CSF; PCC-MRI; age; aqueductus cerebri; sex