title: Ventilator-induced Lung Injury.
abstract: Prevention of ventilator-induced lung injury (VILI) can attenuate multiorgan failure and improve survival in at-risk patients. Clinically significant VILI occurs from volutrauma, barotrauma, atelectrauma, biotrauma, and shear strain. Differences in regional mechanics are important in VILI pathogenesis. Several interventions are available to protect against VILI. However, most patients at risk of lung injury do not develop VILI. VILI occurs most readily in patients with concomitant physiologic insults. VILI prevention strategies must balance risk of lung injury with untoward side effects from the preventive effort, and may be most effective when targeted to subsets of patients at increased risk.
authors.affiliation: Division of Pulmonary and Critical Care Medicine, University of California, San Diego, 200 West Arbor Drive, #8409, San Diego, CA 92103, USA. Electronic address: jbeitler@ucsd.edu.
authors.forename: Jeremy R
authors.initials: JR
authors.lastname: Beitler
authors.affiliation: Division of Pulmonary and Critical Care Medicine, University of California, San Diego, 200 West Arbor Drive, #8409, San Diego, CA 92103, USA.
authors.forename: Atul
authors.initials: A
authors.lastname: Malhotra
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, 55 Fruit Street, Cox 201, Boston, MA 02114, USA.
authors.forename: B Taylor
authors.initials: BT
authors.lastname: Thompson
mesh_terms: D006801:Humans; D055370:Lung Injury / Q000473:pathology*; D012128:Respiratory Distress Syndrome / Q000628:therapy*; D015656:Respiratory Mechanics / Q000502:physiology*; D055397:Ventilator-Induced Lung Injury
keywords: Acute lung injury; Acute respiratory distress syndrome; Mechanical ventilation; Respiratory mechanics; Ventilator-induced lung injury