title: Au(iii) compounds as HIV nucleocapsid protein (NCp7)-nucleic acid antagonists.
abstract: The HIV nucleocapsid NCp7-SL2 RNA interaction is interrupted in the presence of a formally substitution-inert gold(dien)-nucleobase/N-heterocycle AuN4compound where the N-heterocycle serves the dual purposes of a template for "non-covalent" molecular recognition of the essential tryptophan of the protein, mimicking the natural reaction and subsequent "fixation" by Au-Cys bond formation providing a chemotype for a new distinct class of nucleocapsid-nucleic acid antagonist.
authors.affiliation: Department of Chemistry, Virginia Commonwealth University, Richmond, VA 23284-2006, USA. npfarrell@vcu.edu.
authors.forename: Sarah R
authors.initials: SR
authors.lastname: Spell
authors.affiliation: The RNA Institute, University at Albany, State University of New York, 1400 Washington Avenue, Albany, NY 12222, USA.
authors.forename: John B
authors.initials: JB
authors.lastname: Mangrum
authors.affiliation: Department of Chemistry, Virginia Commonwealth University, Richmond, VA 23284-2006, USA. npfarrell@vcu.edu.
authors.forename: Erica J
authors.initials: EJ
authors.lastname: Peterson
authors.affiliation: The RNA Institute, University at Albany, State University of New York, 1400 Washington Avenue, Albany, NY 12222, USA.
authors.forename: Daniele
authors.initials: D
authors.lastname: Fabris
authors.affiliation: Southern Research Institute, 431 Aviation Way, Frederick, Maryland 21701, USA.
authors.forename: Roger
authors.initials: R
authors.lastname: Ptak
authors.affiliation: Department of Chemistry, Virginia Commonwealth University, Richmond, VA 23284-2006, USA. npfarrell@vcu.edu.
authors.forename: Nicholas P
authors.identifier: 0000-0001-7160-7182
authors.initials: NP
authors.lastname: Farrell
mesh_terms: D004305:Dose-Response Relationship, Drug; D015394:Molecular Structure; D050607:Organogold Compounds / Q000737:chemistry* / Q000494:pharmacology*; D012367:RNA, Viral / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship; D054301:gag Gene Products, Human Immunodeficiency Virus / Q000037:antagonists & inhibitors*
chemical_list: C071884:NCP7 protein, Human immunodeficiency virus 1; D050607:Organogold Compounds; D012367:RNA, Viral; D054301:gag Gene Products, Human Immunodeficiency Virus