title: Zebrafish: A Model for the Study of Toxicants Affecting Muscle Development and Function.
abstract: The rapid progress in medicine, agriculture, and allied sciences has enabled the development of a large amount of potentially useful bioactive compounds, such as drugs and pesticides. However, there is another side of this phenomenon, which includes side effects and environmental pollution. To avoid or minimize the uncontrollable consequences of using the newly developed compounds, researchers seek a quick and effective means of their evaluation. In achieving this goal, the zebrafish (Danio rerio) has proven to be a highly useful tool, mostly because of its fast growth and development, as well as the ability to absorb the molecules diluted in water through its skin and gills. In this review, we focus on the reports concerning the application of zebrafish as a model for assessing the impact of toxicants on skeletal muscles, which share many structural and functional similarities among vertebrates, including zebrafish and humans.
authors.affiliation: Department of Animal Developmental Biology, Institute of Experimental Biology, University of Wroclaw, 21 Sienkiewicza Street, 50-335 Wroclaw, Poland. magda.dubinska-magiera@uwr.edu.pl.
authors.forename: Magda
authors.initials: M
authors.lastname: Dubińska-Magiera
authors.affiliation: Department of Animal Developmental Biology, Institute of Experimental Biology, University of Wroclaw, 21 Sienkiewicza Street, 50-335 Wroclaw, Poland. malgorzata.daczewska@uwr.edu.pl.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Daczewska
authors.affiliation: Department of Animal Developmental Biology, Institute of Experimental Biology, University of Wroclaw, 21 Sienkiewicza Street, 50-335 Wroclaw, Poland. anna.lewicka@uwr.edu.pl.
authors.forename: Anna
authors.initials: A
authors.lastname: Lewicka
authors.affiliation: Department of Animal Developmental Biology, Institute of Experimental Biology, University of Wroclaw, 21 Sienkiewicza Street, 50-335 Wroclaw, Poland. marta.migocka-patrzalek@uwr.edu.pl.
authors.forename: Marta
authors.initials: M
authors.lastname: Migocka-Patrzałek
authors.affiliation: Department of Animal Developmental Biology, Institute of Experimental Biology, University of Wroclaw, 21 Sienkiewicza Street, 50-335 Wroclaw, Poland. joanna.niedbalska-tarnowska@uwr.edu.pl.
authors.forename: Joanna
authors.initials: J
authors.lastname: Niedbalska-Tarnowska
authors.affiliation: GReD-Genetics, Reproduction and Development Laboratory, INSERM U1103, CNRS UMR6293, University of Clermont-Auvergne, 28 Place Henri-Dunant, 63000 Clermont-Ferrand, France. christophe.jagla@udamail.fr.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Jagla
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D003358:Cosmetics / Q000633:toxicity; D015870:Gene Expression / Q000187:drug effects; D017930:Genes, Reporter; D049452:Green Fluorescent Proteins / Q000235:genetics / Q000378:metabolism; D015386:Hazardous Substances / Q000633:toxicity*; D019216:Metals, Heavy / Q000633:toxicity; D024510:Muscle Development / Q000187:drug effects* / Q000235:genetics; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000378:metabolism; D010575:Pesticides / Q000633:toxicity; D011619:Psychotropic Drugs / Q000633:toxicity; D036401:Toxicity Tests, Chronic / Q000379:methods*; D014874:Water Pollutants, Chemical / Q000633:toxicity*; D015027:Zebrafish
chemical_list: D003358:Cosmetics; D015386:Hazardous Substances; D019216:Metals, Heavy; D010575:Pesticides; D011619:Psychotropic Drugs; D014874:Water Pollutants, Chemical; D049452:Green Fluorescent Proteins
keywords: biosensors; pollutants; skeletal muscles; toxicants; zebrafish