title: Paraoxonase 1 (Q192R) gene polymorphism, coronary heart disease and the risk of a new acute coronary event.
abstract: BACKGROUND
  Paraoxonase 1 (PON1) plays a major role in the oxidation of low density lipoprotein and in the prevention of coronary atherogenesis. In this context, coding region polymorphisms of PON1 gene, responsible for the enzyme activity, has become of interest as a marker for atherogenesis.
  
  
  METHODS
  A study and follow-up was conducted on 529 patients with an acute coronary event in order to assess the association between the PON1 Q192R (rs662;A/G) polymorphism, the type of acute coronary syndrome, cardiovascular risk factors (arterial hypertension, diabetes mellitus, dyslipidaemia, and smoking), the extent and severity of coronary atherosclerosis, and the medium-term clinical follow-up.
  
  
  RESULTS
  The QQ genotype was found in 245 (46.3%) patients, with 218 (41.2%) patients showing the QR genotype, and 66 (14.5%) patients had the RR genotype. No significant differences were found between the QQ and QR/RR genotypes as regards the clinical characteristics, the analytical data, and the angiographic variables. Similarly, Kaplan-Meier survival analysis showed no significant differences in presenting with a new acute coronary event (p=0.598), cardiac mortality (p=0.701), stent thrombosis (p=0.508), or stent re-stenosis (p=0.598) between QQ and QR/RR genotypes during the follow-up period (3.3±2.2 years).
  
  
  CONCLUSIONS
  In patients with an acute coronary syndrome, the PON1 Q192R genotypes did not influence the risk of suffering a new acute coronary event during the medium-term follow-up.
authors.affiliation: Servico de Cardiología, Hospital Universitario Insular-Materno Infantil, Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain. Electronic address: efrencardio@gmail.com.
authors.forename: Efrén
authors.initials: E
authors.lastname: Martínez-Quintana
authors.affiliation: Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, Spain.
authors.forename: Fayna
authors.initials: F
authors.lastname: Rodríguez-González
authors.affiliation: Servico de Cardiología, Hospital Universitario Insular-Materno Infantil, Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.
authors.forename: José María
authors.initials: JM
authors.lastname: Medina-Gil
authors.affiliation: Unidad de Investigación, Hospital Universitario Insular-Materno Infantil, Las Palmas de Gran Canaria, Spain.
authors.forename: Paloma
authors.initials: P
authors.lastname: Garay-Sánchez
authors.affiliation: Unidad de Investigación, Hospital Universitario Insular-Materno Infantil, Las Palmas de Gran Canaria, Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: Tugores
mesh_terms: D054058:Acute Coronary Syndrome / Q000235:genetics* / Q000503:physiopathology; D000368:Aged; D043303:Aryldialkylphosphatase / Q000235:genetics*; D002318:Cardiovascular Diseases / Q000209:etiology / Q000235:genetics* / Q000503:physiopathology; D003324:Coronary Artery Disease / Q000235:genetics / Q000473:pathology; D003327:Coronary Disease / Q000235:genetics* / Q000503:physiopathology; D005260:Female; D005500:Follow-Up Studies; D005838:Genotype; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index
chemical_list: D043303:Aryldialkylphosphatase; C468406:PON1 protein, human
keywords: Acute coronary event; Coronary artery disease; Enfermedad arterial coronaria; Evento coronario agudo; Paraoxonasa 1; Paraoxonase 1; Polimorfismo; Polymorphism