title: Normobaric oxygen treatment in acute ischemic stroke: a clinical perspective.
abstract: Acute ischemic stroke is a common and serious neurological disease. Oxygen therapy has been shown to increase oxygen supply to ischemic tissues and improve outcomes after cerebral ischemia/reperfusion. Normobaric hyperoxia (NBO), an easily applicable and non-invasive method, shows protective effects on acute ischemic stroke animals and patients in pilot studies. However, many critical scientific questions are still unclear, such as the therapeutic time window of NBO, the long-term effects and the benefits of NBO in large clinic trials. In this article, we review the current literatures on NBO treatment of acute ischemic stroke in preclinical and clinical studies and try to analyze and identify the key gaps or unknowns in our understanding about NBO. Based on these analyses, we provide suggestions for future studies.
authors.affiliation: Cerebrovascular Diseases Research Institute, Xuanwu Hospital of Capital Medical University, Beijing, China; Pediatric Intensive Care, First Affiliated Hospital of Baotou Medical College, Baotou, Inner Mongolia Autonomous Region, China.
authors.forename: Shu-Hai
authors.initials: SH
authors.lastname: Shi
authors.affiliation: Cerebrovascular Diseases Research Institute, Xuanwu Hospital of Capital Medical University, Beijing, China.
authors.forename: Zhi-Feng
authors.initials: ZF
authors.lastname: Qi
authors.affiliation: Cerebrovascular Diseases Research Institute, Xuanwu Hospital of Capital Medical University, Beijing, China.
authors.forename: Yu-Min
authors.initials: YM
authors.lastname: Luo
authors.affiliation: Cerebrovascular Diseases Research Institute, Xuanwu Hospital of Capital Medical University, Beijing, China.
authors.forename: Xun-Ming
authors.identifier: 0000-0002-6588-1617
authors.initials: XM
authors.lastname: Ji
authors.affiliation: Cerebrovascular Diseases Research Institute, Xuanwu Hospital of Capital Medical University, Beijing, China; Department of Pharmaceutical Sciences, College of Pharmacy, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
authors.forename: Ke Jian
authors.identifier: 0000-0002-6588-1617
authors.initials: KJ
authors.lastname: Liu
keywords: clinical studies; ischemia; neuroprotection; normobaric hyperoxia; oxidative stress; oxygen therapy; preclinical studies; stroke