title: Roscoe Owen Brady, MD: Remembrances of co-investigators and colleagues.
abstract: To celebrate the research visions and accomplishments of the late Roscoe O. Brady (1923-2016), remembrance commentaries were requested from several of his postdoctoral research fellows and colleagues. These commentaries not only reflect on the accomplishments of Dr. Brady, but they also share some of the backstories and experiences working in the Brady laboratory. They provide insights and perspectives on Brady's research activities, and especially on his efforts to develop an effective treatment for patients with Type 1 Gaucher disease. These remembrances illuminate Brady's efforts to implement the latest scientific advances with an outstanding team of young co-investigators to develop and demonstrate the safety and effectiveness of the first enzyme replacement therapy for a lysosomal storage disease. Brady's pursuit and persistence in accomplishing his research objectives provide insights into this remarkably successful physician scientist who paved the way for the development of treatments for patients with other lysosomal storage diseases.
authors.affiliation: Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: Robert.desnick@mssm.edu.
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Desnick
authors.affiliation: Neuroscience Therapeutic Area, Shire, Lexington, MA 02421, USA.
authors.forename: Norman W
authors.initials: NW
authors.lastname: Barton
authors.affiliation: Clearwater, FL, USA.
authors.forename: Scott
authors.initials: S
authors.lastname: Furbish
authors.affiliation: Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Grabowski
authors.affiliation: Department of Molecular Medicine and Gene Therapy, Lund University, Lund, Sweden.
authors.forename: Stefan
authors.initials: S
authors.lastname: Karlsson
authors.affiliation: Department of Neurology, New York University School of Medicine, New York, NY 10012, USA.
authors.forename: Edwin H
authors.initials: EH
authors.lastname: Kolodny
authors.affiliation: Departments of Pediatrics and Biochemistry, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Medin
authors.affiliation: Division of Metabolism and Health Effects, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA.
authors.forename: Gary J
authors.initials: GJ
authors.lastname: Murray
authors.affiliation: Departments of Medicine, Pediatrics and Cellular & Molecular Physiology, Yale University School of Medicine, New Haven, CT 06520, USA.
authors.forename: Pramod K
authors.initials: PK
authors.lastname: Mistry
authors.affiliation: Departments of Neurology, Pediatrics and Medical Genetics, Mayo Clinic, Rochester, MN 55905, USA.
authors.forename: Marc C
authors.initials: MC
authors.lastname: Patterson
authors.affiliation: Institute of Metabolic Disease, Baylor Research Institute, Dallas, TX 75087, USA.
authors.forename: Raphael
authors.initials: R
authors.lastname: Schiffmann
authors.affiliation: Department of Human Genetics and Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
authors.forename: Neal J
authors.initials: NJ
authors.lastname: Weinreb
mesh_terms: D056947:Enzyme Replacement Therapy / Q000266:history* / Q000379:methods; D005776:Gaucher Disease / Q000188:drug therapy; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D016464:Lysosomal Storage Diseases / Q000188:drug therapy*; D012108:Research Personnel