title: The Various Metabolic Sources of Histone Acetylation.
abstract: Glucose-derived acetyl-CoA levels directly impact histone acetylation, linking the energetic status of the cell to its epigenome. Two recent reports showed that other carbon sources can contribute to the acetyl-CoA pool used for histone acetylation, highlighting the metabolic plasticity that allows cells to respond to nutrient availability.
authors.affiliation: Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA 02114, USA; Massachusetts General Hospital Center for Regenerative Medicine, Harvard Medical School, Boston, MA 02114, USA.
authors.forename: Carlos
authors.initials: C
authors.lastname: Sebastián
authors.affiliation: Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA 02114, USA; Massachusetts General Hospital Center for Regenerative Medicine, Harvard Medical School, Boston, MA 02114, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address: rmostoslavsky@mgh.harvard.edu.
authors.forename: Raul
authors.initials: R
authors.lastname: Mostoslavsky
mesh_terms: D000105:Acetyl Coenzyme A / Q000235:genetics / Q000378:metabolism; D000107:Acetylation; D000818:Animals; D044127:Epigenesis, Genetic / Q000235:genetics; D006657:Histones / Q000378:metabolism*; D006801:Humans
chemical_list: D006657:Histones; D000105:Acetyl Coenzyme A