title: Hemolysis generation from a novel, linear positive displacement blood pump for cardiopulmonary bypass on a six kilogram piglet: a preliminary report.
abstract: BACKGROUND
  Current blood pumps used for cardiopulmonary bypass generally fall into two different pump design categories; non-occlusive centrifugal pumps and occlusive, positive-displacement roller pumps. The amount of foreign surface area of extracorporeal circuits correlates with post-operative morbidity due to systemic inflammation, leading to a push for technology that reduces the amount of foreign surfaces. Current roller pumps are bulky and the tubing forms an arc in the pumping chamber (raceway), positioning the inlet 360 degrees from the outlet, making it very difficult to place the pump closer to the patient and to efficiently reduce tubing length. These challenges put existing roller pumps at a disadvantage for use in a compact cardiopulmonary bypass circuit. Centrifugal blood pumps are easier to incorporate into miniature circuit designs. However, the prime volumes of current centrifugal pump designs are large, especially for pediatric extracorporeal circuits where the prime volumes are too great to be of clinical value.
  
  
  METHODS
  We describe a preliminary report on a novel, occlusive, linear, single-helix, positive-displacement blood pump which allows for decreased prime volume and surface area of the extracorporeal circuit. This new experimental pump design was used to perfuse a 6 kilogram piglet with a pediatric cardiopulmonary bypass circuit for two hours of continuous use. Blood samples were obtained every thirty minutes and assayed for plasma free hemolysis generation.
  
  
  CONCLUSIONS
  The results from this initial experiment showed low plasma free hemoglobin generation and encourages the authors to further develop this concept.
authors.affiliation: 1 Heart Institute, Children's Hospital Colorado, Aurora, CO, USA.
authors.forename: D Scott
authors.initials: DS
authors.lastname: Lawson
authors.affiliation: 2 Montview Biomedical Design, Aurora, CO, USA.
authors.forename: Derek
authors.initials: D
authors.lastname: Eilers
authors.affiliation: 3 Anschutz Medical Campus, University of Colorado Denver, Denver, CO, USA.
authors.forename: Suzanne
authors.initials: S
authors.lastname: Osorio Lujan
authors.affiliation: 3 Anschutz Medical Campus, University of Colorado Denver, Denver, CO, USA.
authors.forename: Maria
authors.initials: M
authors.lastname: Bortot
authors.affiliation: 3 Anschutz Medical Campus, University of Colorado Denver, Denver, CO, USA.
authors.forename: James
authors.initials: J
authors.lastname: Jaggers
mesh_terms: D000818:Animals; D002315:Cardiopulmonary Bypass / Q000295:instrumentation* / Q000379:methods*; D005260:Female; D006353:Heart-Assist Devices; D006461:Hemolysis; D013552:Swine
keywords: blood pump; cardiopulmonary bypass; extracorporeal circulation; hemolysis; perfusion