title: Magnetic resonance imaging spectrum of perinatal hypoxic-ischemic brain injury.
abstract: Perinatal hypoxic-ischemic brain injury results in neonatal hypoxic-ischemic encephalopathy and serious long-term neurodevelopmental sequelae. Magnetic resonance imaging (MRI) of the brain is an ideal and safe imaging modality for suspected hypoxic-ischemic injury. The pattern of injury depends on brain maturity at the time of insult, severity of hypotension, and duration of insult. Time of imaging after the insult influences the imaging findings. Mild to moderate hypoperfusion results in germinal matrix hemorrhages and periventricular leukomalacia in preterm neonates and parasagittal watershed territory infarcts in full-term neonates. Severe insult preferentially damages the deep gray matter in both term and preterm infants. However, associated frequent perirolandic injury is seen in term neonates. MRI is useful in establishing the clinical diagnosis, assessing the severity of injury, and thereby prognosticating the outcome. Familiarity with imaging spectrum and insight into factors affecting the injury will enlighten the radiologist to provide an appropriate diagnosis.
authors.affiliation: Department of Radiology, Jubilee Mission Medical College and Research Institute, Thrissur, Kerala, India.
authors.forename: Binoj
authors.initials: B
authors.lastname: Varghese
authors.affiliation: Department of Paediatrics, Jubilee Mission Medical College and Research Institute, Thrissur, Kerala, India.
authors.forename: Rose
authors.initials: R
authors.lastname: Xavier
authors.affiliation: Department of Paediatrics, Jubilee Mission Medical College and Research Institute, Thrissur, Kerala, India.
authors.forename: V C
authors.initials: VC
authors.lastname: Manoj
authors.affiliation: Department of Radiology, Jubilee Mission Medical College and Research Institute, Thrissur, Kerala, India.
authors.forename: M K
authors.initials: MK
authors.lastname: Aneesh
authors.affiliation: Department of Radiology, Jubilee Mission Medical College and Research Institute, Thrissur, Kerala, India.
authors.forename: P S
authors.initials: PS
authors.lastname: Priya
authors.affiliation: Department of Radiology, Jubilee Mission Medical College and Research Institute, Thrissur, Kerala, India.
authors.forename: Ashok
authors.initials: A
authors.lastname: Kumar
authors.affiliation: Department of Paediatrics, Amala Institute of Medical Sciences, Thrissur, Kerala, India.
authors.forename: V K
authors.initials: VK
authors.lastname: Sreenivasan
keywords: Cortical highlighting; germinal matrix hemorrhage; hypoxic ischemic encephalopathy; hypoxic ischemic injury; periventricular leukomalacia