title: Diabetic Wound Healing and Activation of Nrf2 by Herbal Medicine.
abstract: Nrf2 defense is a very important cellular mechanism to control oxidative stress, which is implicated in wound healing. Nrf2 can induce many cytoprotective genes, including HO-1, NQO1 and G6PD. Among many natural products that have been reported as Nrf2 activators, sulforaphane and curcumin have been studied more widely than any others, and both are in clinical trials for non-cancerous disorders. Recently, we reported 4-ethyl catechol and 4-vinyl catechol as Nrf2 co-factors that can induce Nrf2 as potently as sulforaphane and curcumin. These new Nrf2 co-factors were identified in hot aqueous extract of an herbal medicineBarleria lupulina, and fermented Noni (Morinda citrifolia) juice, which are used traditionally for diabetic wound healing.
authors.affiliation: Department of Pathology and Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.
authors.forename: Donald R
authors.initials: DR
authors.lastname: Senger
authors.affiliation: Department of Pharmaceutical Sciences, Daniel K Inouye College of Pharmacy, University of Hawaii at Hilo, 200 W. Kawili Street, Hilo, HI 96720, USA.
authors.forename: Shugeng
authors.initials: S
authors.lastname: Cao
keywords: Barleria lupulina; Morinda citrifolia; Nrf2; alkyl catechols; diabetic wound healing; herbal medicine