title: [Atypical mucocutaneous manifestations in neonates and infants with chikungunya fever in the municipalities of Cúcuta, Los Patios and Villa del Rosario, Norte de Santander, Colombia, 2014].
abstract: BACKGROUND
  Atypical clinical manifestations have been observed in newborns and infants suffering from fever caused by the chikungunya virus. Objective: To describe the cases of fever caused by the chikungunya virus in newborns and infants with atypical mucocutaneous lesions. Materials and methods: We reviewed the clinical records, as well as lab tests and histopathological results, of newborns and infants diagnosed with Chikungunya virus and atypical mucocutaneous lesions in three regional hospitals. Results: Out of 18 suspected cases of chikungunya virus in newborns and infants, 11 were positive and presented atypical mucocutaneous manifestations. Six of the eleven confirmed cases corresponded to children under five months of age. The most common symptoms were fever, skin rash, irritability, and diarrhea. Three of the patients were infected with both dengue and chikungunya viruses. The ulcers occurred in the scalp, abdomen, genital and perianal region.
  
  
  CONCLUSIONS
  We report mucocutaneous manifestations in newborns and infants diagnosed with fever caused by the chikungunya virus in Colombia. The rapid development of ulcers is most likely due to the immune response to the virus. Special attention should be given to pregnant women presenting symptoms of chikungunya virus infection prior to delivery, and their offspring should be followed-up in order to monitor possible complications.
authors.affiliation: Grupo de Epidemiología Aplicada, Dirección de Vigilancia y Análisis del Riesgo en Salud Pública, Instituto Nacional de Salud, Bogotá, D.C., Colombia. cmunoz@ins.gov.co.
authors.forename: Claudia Marcela
authors.initials: CM
authors.lastname: Muñoz
authors.forename: José Orlando
authors.initials: JO
authors.lastname: Castillo
authors.forename: Daniela
authors.initials: D
authors.lastname: Salas
authors.forename: Milena Alexandra
authors.initials: MA
authors.lastname: Valderrama
authors.forename: Claudia Teresa
authors.initials: CT
authors.lastname: Rangel
authors.forename: Heiddy Patricia
authors.initials: HP
authors.lastname: Vargas
authors.forename: Diana Carolina
authors.initials: DC
authors.lastname: Silva
mesh_terms: D065632:Chikungunya Fever / Q000150:complications*; D002646:Chikungunya virus; D002947:Cities; D003105:Colombia; D003715:Dengue; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D009092:Mucous Membrane / Q000473:pathology*; D011247:Pregnancy; D012871:Skin Diseases / Q000821:virology*
keywords: Chikungunya virus/epidemiology; disease outbreaks; infant, newborn; skin manifestations; skin ulcer