title: Regional brain structural abnormality in ischemic stroke patients: a voxel-based morphometry study.
abstract: Our previous study used regional homogeneity analysis and found that activity in some brain areas of patients with ischemic stroke changed significantly. In the current study, we examined structural changes in these brain regions by taking structural magnetic resonance imaging scans of 11 ischemic stroke patients and 15 healthy participants, and analyzing the data using voxel-based morphometry. Compared with healthy participants, patients exhibited higher gray matter density in the left inferior occipital gyrus and right anterior white matter tract. In contrast, gray matter density in the right cerebellum, left precentral gyrus, right middle frontal gyrus, and left middle temporal gyrus was less in ischemic stroke patients. The changes of gray matter density in the middle frontal gyrus were negatively associated with the clinical rating scales of the Fugl-Meyer Motor Assessment (r= -0.609,P= 0.047) and the left middle temporal gyrus was negatively correlated with the clinical rating scales of the nervous functional deficiency scale (r= -0.737,P= 0.010). Our findings can objectively identify the functional abnormality in some brain regions of ischemic stroke patients.
authors.affiliation: Acupuncture and Tuina School/Third Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Wu
authors.affiliation: Acupuncture and Tuina School/Third Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China.
authors.forename: Yu-Mei
authors.initials: YM
authors.lastname: Zhou
authors.affiliation: Acupuncture and Tuina School/Third Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Zeng
authors.affiliation: Acupuncture and Tuina School/Third Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China.
authors.forename: Zheng-Jie
authors.initials: ZJ
authors.lastname: Li
authors.affiliation: China Academy of Chinese Medical Sciences, World Federation of Acupuncture-Moxibustion Societies, Beijing, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Luo
authors.affiliation: Institute of Clinical Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong Province, China.
authors.forename: Yong-Xin
authors.initials: YX
authors.lastname: Li
authors.affiliation: Acupuncture and Tuina School/Third Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Fan
authors.affiliation: Radiology Department, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China.
authors.forename: Li-Hua
authors.initials: LH
authors.lastname: Qiu
authors.affiliation: Life Sciences Research Center, School of Life Sciences and Technology, Xidian University, Xi'an, Shaanxi Province, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Qin
authors.affiliation: Acupuncture and Tuina School/Third Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Chen
authors.affiliation: Acupuncture and Tuina School/Third Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Bai
authors.affiliation: Acupuncture and Tuina School/Third Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Nie
authors.affiliation: Acupuncture and Tuina School/Third Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China.
authors.forename: San
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Acupuncture and Tuina School/Third Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Xiong
authors.affiliation: Acupuncture and Tuina School/Third Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Bai
authors.affiliation: Acupuncture and Tuina School/Third Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China.
authors.forename: Can-Xin
authors.initials: CX
authors.lastname: Yin
authors.affiliation: Acupuncture and Tuina School/Third Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China.
authors.forename: Fan-Rong
authors.identifier: 0000-0002-8598-3936
authors.initials: FR
authors.lastname: Liang
keywords: Fugl-Meyer Motor Assessment; brain structure abnormality; functional deficiency; functional magnetic resonance imaging; gray matter density; ischemic stroke; nerve regeneration; nervous functional deficiency scale; neural regeneration; neural reorganization; neuroplasticity; voxel-based morphometry