title: Cardiovascular disease and physical activity in adult cancer survivors: a nested, retrospective study from the Atlantic PATH cohort.
abstract: The study aimed to examine the relationship between cardiovascular disease (CVD) and physical activity (PA) levels in cancer survivors (CS).
  
  
  
  Using a nested, retrospective follow-up design, this study presents the self-reported prevalence of CVD in an Atlantic Canadian population-based cohort of 1526 CS and 6034 age-sex matched, non-cancer controls ranging from 35 to 69 years of age. Univariate and multiple logistic regression models were used to explore the association between CVD and PA.
  
  
  
  Overall, CS were 30% more likely to have ever experienced a CVD event than controls (OR = 1.3; 95% CI 1-1.7, p = .07). Survivors were also significantly more likely to report having hypertension (OR = 1.60; 95% CI 1.03-1.3, p = .02) and diabetes (OR = 1.27; 95% CI 1.03-1.16, p = .02). Compared to controls, CS were significantly less likely to engage in high levels of PA. For survivors, compared to those who were least physically active, the odds of having a CVD risk factor was 35% lower for those who were moderately active (OR = 0.65; 95% CI 0.48-0.88) and 45% lower in the most highly active group (OR = 0.55; 95% CI 0.4-0.73). For controls, the odds of having a CVD risk factor was 25% lower for those in the moderately active group (OR = 0.75; 95% CI 0.64-0.88) and 30% lower for those in the high active group (OR = 0.70; 95% CI 0.6-0.81).
  
  
  
  Low active survivors appear to be at a high risk of CVD-related comorbidity.
  
  
  
  PA is associated with lower CVD-related comorbidity in CS, suggesting that interventions directed at increasing PA should be implemented to improve long-term health outcomes.
authors.affiliation: School of Health and Human Performance, Dalhousie University, 6230 South Street, Halifax, NS, B3H 4R2, Canada. melanie.keats@dal.ca.
authors.forename: Melanie R
authors.initials: MR
authors.lastname: Keats
authors.affiliation: Population Cancer Research Program, Dalhousie University, 1494 Carlton Street, Halifax, NS, B3H 3B7, Canada.
authors.forename: Yunsong
authors.initials: Y
authors.lastname: Cui
authors.affiliation: School of Health and Human Performance, Dalhousie University, 6230 South Street, Halifax, NS, B3H 4R2, Canada.
authors.forename: Scott A
authors.initials: SA
authors.lastname: Grandy
authors.affiliation: Population Cancer Research Program, Dalhousie University, 1494 Carlton Street, Halifax, NS, B3H 3B7, Canada.
authors.forename: Louise
authors.initials: L
authors.lastname: Parker
mesh_terms: D000328:Adult; D000368:Aged; D002318:Cardiovascular Diseases / Q000209:etiology*; D016022:Case-Control Studies; D015331:Cohort Studies; D015444:Exercise / Q000502:physiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D017741:Survivors
keywords: Cancer; Cardiovascular; Physical activity; Survivor