title: A Canola Oil-Supplemented Diet Prevents Type I Diabetes-Caused Lipotoxicity and Renal Dysfunction in a Rat Model.
abstract: We investigated the effect of a canola oil-supplemented diet on the metabolic state and diabetic renal function of a type I diabetes experimental model. Male Sprague-Dawley rats were randomly divided into four groups: (1) normoglycemic+chow diet, (2) normoglycemic+a canola oil-supplemented chow diet, (3) diabetic+chow diet, and (4) diabetic+a canola oil-supplemented chow diet. For 15 weeks, animals were fed a diet of Purina rat chow alone or supplemented with 30% canola oil. Energetic intake, water intake, body weight, and adipose tissue fat pad were measured; renal function, electrolyte balance, glomerular filtration rate, and the plasmatic concentration of free fatty acids, cholesterol, triglycerides, and glucose were evaluated. The mesenteric, retroperitoneal, and epididymal fat pads were dissected and weighed. The kidneys were used for lipid peroxidation (LP) and reactive oxygen species (ROS) quantifications. Diabetic rats fed with a canola oil-supplemented diet had higher body weights, were less hyperphagic, and their mesenteric, retroperitoneal, and epididymal fat pads weighed more than diabetic rats on an unsupplemented diet. The canola oil-supplemented diet decreased plasmatic concentrations of free fatty acids, triglycerides, and cholesterol; showed improved osmolarity, water clearances, and creatinine depuration; and had decreased LP and ROS. A canola oil-supplemented diet decreases hyperphagia and prevents lipotoxicity and renal dysfunction in a type I diabetes mellitus model.
authors.affiliation: 1 Laboratorio de Metabolismo, Departamento de Fisiología, ENCB, Instituto Politécnico Nacional , Gustavo Madero, México, Distrito Federal.
authors.forename: Edgar
authors.initials: E
authors.lastname: Cano-Europa
authors.affiliation: 1 Laboratorio de Metabolismo, Departamento de Fisiología, ENCB, Instituto Politécnico Nacional , Gustavo Madero, México, Distrito Federal.
authors.forename: Rocio
authors.initials: R
authors.lastname: Ortiz-Butron
authors.affiliation: 2 Laboratorio de Toxicología Hepática y Renal, Departamento de Farmacia. ENCB, Instituto Politécnico Nacional , Gustavo Madero, México, Distrito Federal.
authors.forename: Estela Melendez
authors.initials: EM
authors.lastname: Camargo
authors.affiliation: 2 Laboratorio de Toxicología Hepática y Renal, Departamento de Farmacia. ENCB, Instituto Politécnico Nacional , Gustavo Madero, México, Distrito Federal.
authors.forename: María Miriam
authors.initials: MM
authors.lastname: Esteves-Carmona
authors.affiliation: 3 Laboratorio de Mediciones del Instituto Tecnológico de Veracruz, UNIDA , Veracruz, México.
authors.forename: Rosa Maria
authors.initials: RM
authors.lastname: Oliart-Ros
authors.affiliation: 1 Laboratorio de Metabolismo, Departamento de Fisiología, ENCB, Instituto Politécnico Nacional , Gustavo Madero, México, Distrito Federal.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Blas-Valdivia
authors.affiliation: 1 Laboratorio de Metabolismo, Departamento de Fisiología, ENCB, Instituto Politécnico Nacional , Gustavo Madero, México, Distrito Federal.
authors.forename: Margarita
authors.initials: M
authors.lastname: Franco-Colin
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000178:diet therapy* / Q000503:physiopathology / Q000517:prevention & control*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000178:diet therapy* / Q000503:physiopathology / Q000517:prevention & control*; D019587:Dietary Supplements; D004326:Drinking / Q000187:drug effects; D002149:Energy Intake / Q000187:drug effects; D005227:Fatty Acids / Q000097:blood; D005919:Glomerular Filtration Rate / Q000187:drug effects; D007668:Kidney / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology*; D015227:Lipid Peroxidation; D008297:Male; D009765:Obesity / Q000378:metabolism; D010938:Plant Oils / Q000008:administration & dosage*; D011897:Random Allocation; D000074262:Rapeseed Oil; D051381:Rats; D017207:Rats, Sprague-Dawley; D014280:Triglycerides / Q000097:blood
chemical_list: D001786:Blood Glucose; D005227:Fatty Acids; D010938:Plant Oils; D000074262:Rapeseed Oil; D014280:Triglycerides; D002784:Cholesterol
keywords: canola oil; lipid metabolism; lipid peroxidation; normoglycemic; oxidative stress; renal function; type I diabetes