title: A superporous and superabsorbent glucuronoxylan hydrogel from quince (Cydonia oblanga): Stimuli responsive swelling, on-off switching and drug release.
abstract: Current study was designed to investigate micromeritic properties, water absorption capacity, stimuli (pH, ethanol and saline) responsive swelling-deswelling (on-off switching) and controlled drug release from the polysaccharide glucuronoxylan isolated from the seeds of Quince. The water retention capacity of Quince hydrogel (QH) was found admirable. The hydrogel also exhibited privileged swelling in water and basic buffers (pH 6.8 and 7.4) while insignificant swelling in acidic buffer (pH 1.2). The swelling kinetics of QH follows second order. Moreover, QH deswells in salt (KCl and NaCl) solutions and ethanol. SEM of swollen then freeze dried QH revealed hollow channels with an average diameter of 67.8μm. Furthermore, QH sustained the release of levosulpiride (LS) tablet formulation and drug release mechanism was ascertained super case-II transport. These results signify QH a smart material for sustained release formulations.
authors.affiliation: Faculty of Pharmacy, University of Sargodha, Sargodha 40100, Pakistan.
authors.forename: Muhammad Umer
authors.initials: MU
authors.lastname: Ashraf
authors.affiliation: Department of Chemistry, University of Sargodha, Sargodha 40100, Pakistan. Electronic address: majaz172@yahoo.com.
authors.forename: Muhammad Ajaz
authors.initials: MA
authors.lastname: Hussain
authors.affiliation: Department of Chemistry, University of Sargodha, Sargodha 40100, Pakistan.
authors.forename: Gulzar
authors.initials: G
authors.lastname: Muhammad
authors.affiliation: Faculty of Pharmacy, University of Sargodha, Sargodha 40100, Pakistan.
authors.forename: Muhammad Tahir
authors.initials: MT
authors.lastname: Haseeb
authors.affiliation: Faculty of Pharmacy, University of Sargodha, Sargodha 40100, Pakistan.
authors.forename: Sajid
authors.initials: S
authors.lastname: Bashir
authors.affiliation: Department of Chemistry, SBA School of Science & Engineering, Lahore University of Management Sciences, Lahore Cantt, 54792, Pakistan.
authors.forename: Syed Zajif
authors.initials: SZ
authors.lastname: Hussain
authors.affiliation: Department of Chemistry, SBA School of Science & Engineering, Lahore University of Management Sciences, Lahore Cantt, 54792, Pakistan.
authors.forename: Irshad
authors.initials: I
authors.lastname: Hussain
mesh_terms: D065966:Absorption, Physicochemical; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D020100:Hydrogels / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D016062:Porosity; D011189:Potassium Chloride / Q000737:chemistry; D027824:Rosaceae / Q000737:chemistry*; D012965:Sodium Chloride / Q000737:chemistry; D014867:Water / Q000737:chemistry; D014990:Xylans / Q000737:chemistry*
chemical_list: D004337:Drug Carriers; D020100:Hydrogels; D014990:Xylans; D014867:Water; C038910:glucuronoxylan; D012965:Sodium Chloride; D011189:Potassium Chloride
keywords: Glucuronoxylan; On-off switching; Quince hydrogel; Superporous hydrogel; Sustained drug release