title: Cutoff Point of HbA1c for Diagnosis of Diabetes Mellitus in Chinese Individuals.
abstract: BACKGROUND
  The purpose of the present study was to find the optimal threshold of glycated hemoglobin (HbA1c) for diagnosis of diabetes mellitus in Chinese individuals.
  
  
  METHODS
  A total of 8 391 subjects (including 2 133 men and 6 258 women) aged 40-90 years with gradable retinal photographs were recruited. The relationship between HbA1c and diabetic retinopathy (DR) was examined. Receiver operating characteristic (ROC) curves were used to find the optimal threshold of HbA1c in screening DR and diagnosing diabetes.
  
  
  RESULTS
  HbA1c values in patients with DR were significantly higher than in those with no DR. The ROC curve for HbA1c had an area under the curve of 0.881 (95%CI 0.857-0.905; P = 0.000). HbA1c at a cutoff of 6.5% had a high sensitivity (80.6%) and specificity (86.9%) for detecting DR.
  
  
  CONCLUSIONS
  HbA1c can be used to diagnose diabetes in a Chinese population, and the optimal HbA1c cutoff point for diagnosis is 6.5%.
authors.affiliation: Department of Endocrinology, Dalian Municipal Central Hospital Affiliated Of Dalian Medical University, Dalian, China.
authors.forename: Bing
authors.identifier: http://orcid.org/0000-0003-0810-0789
authors.initials: B
authors.lastname: Wang
authors.affiliation: Graduate School, Dalian Medical University, Dalian, China.
authors.forename: Ming-Chuan
authors.initials: MC
authors.lastname: Liu
authors.affiliation: Department of Endocrinology, Dalian Municipal Central Hospital Affiliated Of Dalian Medical University, Dalian, China.
authors.forename: Xin-Yu
authors.initials: XY
authors.lastname: Li
authors.affiliation: Department of Endocrinology, Dalian Municipal Central Hospital Affiliated Of Dalian Medical University, Dalian, China.
authors.forename: Xu-Han
authors.initials: XH
authors.lastname: Liu
authors.affiliation: Department of Endocrinology, Dalian Municipal Central Hospital Affiliated Of Dalian Medical University, Dalian, China.
authors.forename: Qiu-Xia
authors.initials: QX
authors.lastname: Feng
authors.affiliation: Department of Endocrinology, Dalian Municipal Central Hospital Affiliated Of Dalian Medical University, Dalian, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Lu
authors.affiliation: Department of Endocrinology, Dalian Municipal Central Hospital Affiliated Of Dalian Medical University, Dalian, China.
authors.forename: Zhu
authors.initials: Z
authors.lastname: Zhu
authors.affiliation: Department of Endocrinology, Dalian Municipal Central Hospital Affiliated Of Dalian Medical University, Dalian, China.
authors.forename: Ying-Shu
authors.initials: YS
authors.lastname: Liu
authors.affiliation: Department of Endocrinology, Dalian Municipal Central Hospital Affiliated Of Dalian Medical University, Dalian, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhao
authors.affiliation: Department of Endocrinology, Dalian Municipal Central Hospital Affiliated Of Dalian Medical University, Dalian, China.
authors.forename: Zheng-Nan
authors.initials: ZN
authors.lastname: Gao
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D001786:Blood Glucose; D002681:China / Q000453:epidemiology; D015897:Comorbidity; D003920:Diabetes Mellitus / Q000097:blood* / Q000175:diagnosis* / Q000453:epidemiology; D005260:Female; D006442:Glycated Hemoglobin; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011159:Population Surveillance; D015995:Prevalence; D012372:ROC Curve; D012016:Reference Values; D015203:Reproducibility of Results; D012307:Risk Factors
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin