title: Detoxification of Deoxynivalenol via Glycosylation Represents Novel Insights on Antagonistic Activities of Trichoderma when Confronted with Fusarium graminearum.
abstract: Deoxynivalenol (DON) is a mycotoxin mainly produced by theFusarium graminearumcomplex, which are important phytopathogens that can infect crops and lead to a serious disease calledFusariumhead blight (FHB). As the most common B type trichothecene mycotoxin, DON has toxic effects on animals and humans, which poses a risk to food security. Thus, efforts have been devoted to control DON contamination in different ways. Management of DON production byTrichodermastrains as a biological control-based strategy has drawn great attention recently. In our study, eight selectedTrichodermastrains were evaluated for their antagonistic activities onF. graminearumby dual culture on potato dextrose agar (PDA) medium. As potential antagonists,Trichodermastrains showed prominent inhibitory effects on mycelial growth and mycotoxin production ofF. graminearum. In addition, the modified mycotoxin deoxynivalenol-3-glucoside (D3G), which was once regarded as a detoxification product of DON in plant defense, was detected whenTrichodermawere confronted withF. graminearum. The occurrence of D3G inF. graminearumandTrichodermainteraction was reported for the first time, and these findings provide evidence thatTrichodermastrains possess a self-protection mechanism as plants to detoxify DON into D3G when competing withF. graminearum.
authors.affiliation: SIBS-UGENT-SJTU Joint Laboratory of Mycotoxin Research, Key Laboratory of Food Safety Research, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 294 Taiyuan Road, Shanghai 200031, China. tianye@sibs.ac.cn.
authors.forename: Ye
authors.initials: Y
authors.lastname: Tian
authors.affiliation: SIBS-UGENT-SJTU Joint Laboratory of Mycotoxin Research, Key Laboratory of Food Safety Research, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 294 Taiyuan Road, Shanghai 200031, China. yltan@sibs.ac.cn.
authors.forename: Yanglan
authors.initials: Y
authors.lastname: Tan
authors.affiliation: SIBS-UGENT-SJTU Joint Laboratory of Mycotoxin Research, Key Laboratory of Food Safety Research, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 294 Taiyuan Road, Shanghai 200031, China. liuna@sibs.ac.cn.
authors.forename: Na
authors.initials: N
authors.lastname: Liu
authors.affiliation: SIBS-UGENT-SJTU Joint Laboratory of Mycotoxin Research, Key Laboratory of Food Safety Research, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 294 Taiyuan Road, Shanghai 200031, China. zyan@sibs.ac.cn.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Yan
authors.affiliation: College of Plant Science and Technology, Huazhong Agricultural University, Wuhan 430070, China. yucailiao@mail.hzau.edu.cn.
authors.forename: Yucai
authors.initials: Y
authors.lastname: Liao
authors.affiliation: Department of Resources and Environment Sciences, School of Agriculture and Biology, Shanghai Jiaotong University, 800 Dongchuan Road, Shanghai 200240, China. jiechen59@sjtu.edu.cn.
authors.forename: Jie
authors.initials: J
authors.lastname: Chen
authors.affiliation: Laboratory of Food Analysis, Department of Bioanalysis, Faculty of Pharmaceutical Sciences, Ghent University, Ottergemsesteenweg 460, B-9000 Ghent, Belgium. Sarah.DeSaeger@UGent.be.
authors.forename: Sarah
authors.initials: S
authors.lastname: de Saeger
authors.affiliation: State Key Laboratory Breeding Base for Zhejiang Sustainable Pest and Disease Control, Institute of Quality and Standard for Agro-Products, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China. yanghua806@hotmail.com.
authors.forename: Hua
authors.initials: H
authors.lastname: Yang
authors.affiliation: State Key Laboratory Breeding Base for Zhejiang Sustainable Pest and Disease Control, Institute of Quality and Standard for Agro-Products, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China. yanyan0014@163.com.
authors.forename: Qiaoyan
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: SIBS-UGENT-SJTU Joint Laboratory of Mycotoxin Research, Key Laboratory of Food Safety Research, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 294 Taiyuan Road, Shanghai 200031, China. abwu@sibs.ac.cn.
authors.forename: Aibo
authors.initials: A
authors.lastname: Wu
mesh_terms: D061046:Biological Control Agents; D018920:Coculture Techniques; D005670:Fusarium / Q000254:growth & development / Q000378:metabolism*; D006031:Glycosylation; D025282:Mycelium / Q000254:growth & development; D014242:Trichoderma / Q000254:growth & development; D014255:Trichothecenes / Q000378:metabolism*
chemical_list: D061046:Biological Control Agents; D014255:Trichothecenes; C007262:deoxynivalenol
keywords: Trichoderma; biological control; modified mycotoxin; mycotoxin; toxigenic Fusarium