title: Increased mean aliphatic lipid chain length in left ventricular hypertrophy secondary to arterial hypertension: A cross-sectional study.
abstract: About 77.9 million (1 in 4) American adults have high blood pressure. High blood pressure is the primary cause of left ventricular hypertrophy (LVH), which represents a strong predictor of future heart failure and cardiovascular mortality. Previous studies have shown an altered metabolic profile in hypertensive patients with LVH. The goal of this study was to identify blood metabolomic LVH biomarkers by H NMR to provide novel diagnostic tools for rapid LVH detection in populations of hypertensive individuals. This cross-sectional study included 48 hypertensive patients with LVH matched with 48 hypertensive patients with normal LV size, and 24 healthy controls. Two-dimensional targeted M-mode echocardiography was performed to measure left ventricular mass index. Partial least squares discriminant analysis was used for the multivariate analysis of the H NMR spectral data. From the H NMR-based metabolomic profiling, signals coming from methylene (-CH2-) and methyl (-CH3) moieties of aliphatic chains from plasma lipids were identified as discriminant variables. The -CH2-/-CH3 ratio, an indicator of the mean length of the aliphatic lipid chains, was significantly higher (P < 0.001) in the LVH group than in the hypertensive group without LVH and controls. Receiver operating characteristic curve showed that a cutoff of 2.34 provided a 52.08% sensitivity and 85.42% specificity for discriminating LVH (AUC = 0.703, P-value < 0.001). We propose the -CH2-/-CH3 ratio from plasma aliphatic lipid chains as a biomarker for the diagnosis of left ventricular remodeling in hypertension.
authors.affiliation: UMR UT3 CNRS 5288 Evolutionary Medicine, Obesity and Heart Failure: Molecular and Clinical Investigations, INI-CRCT F-CRIN, GREAT Networks, Toulouse Cedex 4, France University of Camerino, Camerino, Italy Department of Physiology and Biophysics, Mississippi Center for Obesity Research, Mississippi Center for Heart Research, University of Mississippi Medical Center, Jackson, MS Emergency Medicine at the Baylor College of Medicine in Houston, Houston, TX Toulouse University Hospital, Toulouse Spartacus-Biomed, Clermont le Fort, France.
authors.forename: Maria Francesca
authors.initials: MF
authors.lastname: Evaristi
authors.forename: Céline
authors.initials: C
authors.lastname: Caubère
authors.forename: Romain
authors.initials: R
authors.lastname: Harmancey
authors.forename: Franck
authors.initials: F
authors.lastname: Desmoulin
authors.forename: William Frank
authors.initials: WF
authors.lastname: Peacock
authors.forename: Matthieu
authors.initials: M
authors.lastname: Berry
authors.forename: Annie
authors.initials: A
authors.lastname: Turkieh
authors.forename: Manon
authors.initials: M
authors.lastname: Barutaut
authors.forename: Michel
authors.initials: M
authors.lastname: Galinier
authors.forename: Camille
authors.initials: C
authors.lastname: Dambrin
authors.forename: Carlo
authors.initials: C
authors.lastname: Polidori
authors.forename: Cristina
authors.initials: C
authors.lastname: Miceli
authors.forename: Bernard
authors.initials: B
authors.lastname: Chamontin
authors.forename: François
authors.initials: F
authors.lastname: Koukoui
authors.forename: Jerôme
authors.initials: J
authors.lastname: Roncalli
authors.forename: Pierre
authors.initials: P
authors.lastname: Massabuau
authors.forename: Fatima
authors.initials: F
authors.lastname: Smih
authors.forename: Philippe
authors.initials: P
authors.lastname: Rouet
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications; D017379:Hypertrophy, Left Ventricular / Q000097:blood* / Q000209:etiology; D008055:Lipids / Q000097:blood*; D008297:Male; D055432:Metabolomics; D008875:Middle Aged
chemical_list: D015415:Biomarkers; D008055:Lipids