title: Pediatric case of anaplastic lymphoma kinase-positive anaplastic large cell lymphoma forming a solitary skin tumor on the forearm.
abstract: A 5-year-old girl noticed a rapidly growing reddish nodule on her right forearm. Although oral antibiotics had been administrated for 2 weeks, the tumor enlarged. Skin biopsy revealed excessive infiltration of atypical neoplastic cells expressing CD4, CD30 and anaplastic lymphoma kinase (ALK). These histological and immunohistochemical findings were consistent with anaplastic large cell lymphoma (ALCL). Computed tomography showed multiple lymphadenopathy, but lymph node biopsy and bone marrow examination did not show any evidence of systemic dissemination. However, due to the positive results for ALK and multiple lymphadenopathy, we diagnosed ALK-positive ALCL forming a solitary skin tumor on the forearm. The patient received chemotherapy and presented marked improvement. This paper discusses the difficulty of diagnosing pediatric ALK-positive ALCL limited to the skin and reviews the medical published work.
authors.affiliation: Department of Dermatology, Tokai University School of Medicine, Kanagawa, Japan.
authors.forename: Michio
authors.initials: M
authors.lastname: Tokuyama
authors.affiliation: Department of Dermatology, Tokai University School of Medicine, Kanagawa, Japan.
authors.forename: Yuta
authors.initials: Y
authors.lastname: Kurashige
authors.affiliation: Department of Dermatology, Tokai University School of Medicine, Kanagawa, Japan.
authors.forename: Tami
authors.initials: T
authors.lastname: Ota
authors.affiliation: Department of Dermatology, Tokai University School of Medicine, Kanagawa, Japan.
authors.forename: Yasuaki
authors.initials: Y
authors.lastname: Manabe
authors.affiliation: Department of Dermatology, Tokai University School of Medicine, Kanagawa, Japan.
authors.forename: Hanako
authors.initials: H
authors.lastname: Yamaoka
authors.affiliation: Department of Dermatology, Tokai University School of Medicine, Kanagawa, Japan.
authors.forename: Norihiro
authors.initials: N
authors.lastname: Ikoma
authors.affiliation: Department of Pediatrics, Tokai University School of Medicine, Kanagawa, Japan.
authors.forename: Akiko
authors.initials: A
authors.lastname: Fukumura
authors.affiliation: Department of Pediatrics, Tokai University School of Medicine, Kanagawa, Japan.
authors.forename: Michie
authors.initials: M
authors.lastname: Miyashita
authors.affiliation: Department of Pediatrics, Tokai University School of Medicine, Kanagawa, Japan.
authors.forename: Keisuke
authors.initials: K
authors.lastname: Otsubo
authors.affiliation: Department of Pediatrics, Tokai University School of Medicine, Kanagawa, Japan.
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Morimoto
authors.affiliation: Department of Pediatrics, Tokai University School of Medicine, Kanagawa, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Mochizuki
authors.affiliation: Department of Pathology, Tokai University School of Medicine, Kanagawa, Japan.
authors.forename: Natsuko
authors.initials: N
authors.lastname: Nakano
authors.affiliation: Department of Pathology, Tokai University School of Medicine, Kanagawa, Japan.
authors.forename: Naoya
authors.initials: N
authors.lastname: Nakamura
authors.affiliation: Department of Dermatology, Tokai University School of Medicine, Kanagawa, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Ozawa
authors.affiliation: Department of Dermatology, Tokai University School of Medicine, Kanagawa, Japan.
authors.forename: Tomotaka
authors.initials: T
authors.lastname: Mabuchi
mesh_terms: D000077548:Anaplastic Lymphoma Kinase; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001706:Biopsy; D002467:Cell Nucleus; D002675:Child, Preschool; D003593:Cytoplasm; D005260:Female; D005542:Forearm; D006801:Humans; D007150:Immunohistochemistry; D017728:Lymphoma, Large-Cell, Anaplastic / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology / Q000628:therapy; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism*; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology
chemical_list: D000970:Antineoplastic Agents; C000626173:ALK protein, human; D000077548:Anaplastic Lymphoma Kinase; D020794:Receptor Protein-Tyrosine Kinases
keywords: anaplastic large cell lymphoma; anaplastic lymphoma kinase; chemotherapy; children; skin