title: Guide to the Pharmacology of Mitochondrial Potassium Channels.
abstract: This chapter provides a critical overview of the available literature on the pharmacology of mitochondrial potassium channels. In the first part, the reader is introduced to the topic, and eight known protein contributors to the potassium permeability of the inner mitochondrial membrane are presented. The main part of this chapter describes the basic characteristics of each channel type mentioned in the introduction. However, the most important and valuable information included in this chapter concerns the pharmacology of mitochondrial potassium channels. Several available channel modulators are critically evaluated and rated by suitability for research use. The last figure of this chapter shows the results of this evaluation at a glance. Thus, this chapter can be very useful for beginners in this field. It is intended to be a time- and resource-saving guide for those searching for proper modulators of mitochondrial potassium channels.
authors.affiliation: Laboratory of Intracellular Ion Channels, Department of Biochemistry, Nencki Institute of Experimental Biology, 3 Pasteur Street, 02-093, Warsaw, Poland.
authors.forename: Bartłomiej
authors.initials: B
authors.lastname: Augustynek
authors.affiliation: Department of Epileptology, University of Bonn, Sigmund-Freud-Str. 25, 53105, Bonn, Germany.
authors.forename: Wolfram S
authors.initials: WS
authors.lastname: Kunz
authors.affiliation: Laboratory of Intracellular Ion Channels, Department of Biochemistry, Nencki Institute of Experimental Biology, 3 Pasteur Street, 02-093, Warsaw, Poland. adam@nencki.gov.pl.
authors.forename: Adam
authors.initials: A
authors.lastname: Szewczyk
mesh_terms: D000818:Animals; D006801:Humans; D051037:Large-Conductance Calcium-Activated Potassium Channel alpha Subunits / Q000187:drug effects / Q000502:physiology; D008928:Mitochondria / Q000378:metabolism*; D015221:Potassium Channels / Q000187:drug effects* / Q000502:physiology; D024642:Potassium Channels, Voltage-Gated / Q000187:drug effects / Q000502:physiology
chemical_list: C494841:KCNMA1 protein, human; D051037:Large-Conductance Calcium-Activated Potassium Channel alpha Subunits; D015221:Potassium Channels; D024642:Potassium Channels, Voltage-Gated; C117780:mitochondrial K(ATP) channel
keywords: Cytoprotection; Ischemic preconditioning; Mitochondria; Mitochondrial potassium channels; Modulators of potassium channels; Potassium channel openers; mitoBKCa; mitoIKCa; mitoKATP; mitoKv1.3; mitoKv7.4; mitoSKCa; mitoSLO2; mitoTASK3