title: Prominent increased calcineurin immunoreactivity in the superior temporal gyrus in schizophrenia: A postmortem study.
abstract: Many neuroimaging studies have demonstrated structural changes in the superior temporal gyrus (STG) in patients with schizophrenia. Several postmortem studies have reported on the pathogenesis of schizophrenia, but few reports have investigated alterations in molecules in the STG. In addition, several studies have suggested that calcineurin (CaN) inadequacy may be a risk factor for schizophrenia, but no reports about CaN expression in the STG in schizophrenia have been published. We compared the density of CaN-immunoreactive (CaN-IR) neurons in the STG from 11 patients with schizophrenia with that of 11 sex- and age-matched controls. We used immunohistochemical analysis with rabbit polyclonal antibodies against human CaN. In the STG, the density of CaN-IR neurons in layers II - VI in the group with schizophrenia was significantly higher than that in the control group. Our results confirmed pathological changes in the STG in patients with schizophrenia, suggesting that alterations in the CaN pathway play a role in the pathogenesis of schizophrenia.
authors.affiliation: Department of Neuropsychiatry, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima City, Fukushima 960-1295, Japan; Department of Neuropsychiatry, The University of Tokyo Hospital, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. Electronic address: nishityo4nishihara@gmail.com.
authors.forename: Akira
authors.initials: A
authors.lastname: Wada
authors.affiliation: Department of Neuropsychiatry, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima City, Fukushima 960-1295, Japan; Departments of Psychiatry, Aizu Medical Center, Fukushima Medical University, 21-2 Maeda, Tanisawa Kawahigashimachi, Aizuwakamatsu city, Fukushima 969-3492, Japan.
authors.forename: Yasuto
authors.initials: Y
authors.lastname: Kunii
authors.affiliation: Department of Neuropsychiatry, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima City, Fukushima 960-1295, Japan.
authors.forename: Jyunya
authors.initials: J
authors.lastname: Matsumoto
authors.affiliation: Department of Neuropsychiatry, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima City, Fukushima 960-1295, Japan.
authors.forename: Mizuki
authors.initials: M
authors.lastname: Hino
authors.affiliation: Department of Neuropsychiatry, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima City, Fukushima 960-1295, Japan.
authors.forename: Qiaohui
authors.initials: Q
authors.lastname: Yang
authors.affiliation: Department of Neuropsychiatry, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima City, Fukushima 960-1295, Japan; Departments of Psychiatry, Aizu Medical Center, Fukushima Medical University, 21-2 Maeda, Tanisawa Kawahigashimachi, Aizuwakamatsu city, Fukushima 969-3492, Japan.
authors.forename: Shin-Ichi
authors.initials: SI
authors.lastname: Niwa
authors.affiliation: Department of Neuropsychiatry, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima City, Fukushima 960-1295, Japan.
authors.forename: Hirooki
authors.initials: H
authors.lastname: Yabe
mesh_terms: D000328:Adult; D000818:Animals; D000906:Antibodies / Q000032:analysis*; D001344:Autopsy; D019703:Calcineurin / Q000276:immunology*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D059906:Neuroimaging / Q000379:methods; D009474:Neurons / Q000276:immunology*; D011817:Rabbits; D012559:Schizophrenia / Q000000981:diagnostic imaging / Q000276:immunology / Q000473:pathology*; D013702:Temporal Lobe / Q000000981:diagnostic imaging / Q000276:immunology / Q000473:pathology*
chemical_list: D000906:Antibodies; D019703:Calcineurin