title: Comparison of prognostic significance of mean platelet volume/platelet count with GRACE for long-term prognosis in patients with non-ST-segment elevation myocardial infarction undergoing percutaneous coronary intervention.
abstract: BACKGROUND
  Mean platelet volume to platelet count ratio (MPV/P ratio) has been demonstrated to be a predictor of adverse outcome in patients with non-ST-segment elevation myocardial infarction (NSTEMI). We aimed to assess whether MPV/P ratio is a useful marker to predict long-term prognosis in NSTEMI patients undergoing PCI. Moreover, the prognostic accuracy of MPV/P ratio was compared with MPV and GRACE score.
  
  
  METHODS
  In a retrospective cohort study, according to the baseline MPV/P values, 887 consecutive NSTEMI patients undergoing PCI were divided into two groups: the high MPV/P group (n=296, MPV/P ≥0.054) and the low MPV/P group (n=591, MPV/P<0.054). Clinical endpoints were all-cause mortality and all-cause mortality/nonfatal reinfarction.
  
  
  RESULTS
  Multivariate analysis showed that high MPV/P was an independent predictor of all-cause mortality [HRs: 1.973, 95% CI: 1.528-2.549, P<0.001], and all-cause mortality/nonfatal myocardial reinfarction [HRs: 1.289, 95% CI: 1.181-1.408, P<0.001]. MPV/P ratio has good accuracy for predicting clinical endpoints. The discriminatory performance of MPV/P ratio was similar to GRACE score but better than MPV (for all-cause mortality: MPV/P vs. GRACE: z=0.205, p=0.837; MPV/P vs. MPV: z=2.677, p=0.008; GRACE vs. MPV: z=3.017, p=0.003; for all-cause mortality/nonfatal myocardial: MPV/P vs. GRACE: z=1.098, p=0.272; MPV/P vs. MPV: z=4.026, p<0.001; GRACE vs. MPV: z=4.962, p<0.001).
  
  
  CONCLUSIONS
  MPV/P ratio was similar to GRACE score but better than MPV for predicting all-cause mortality and all-cause mortality/nonfatal myocardial reinfarction in NSTEMI patients undergoing PCI. However, MPV/P ratio is easier to calculate than GRACE score.
authors.affiliation: Department of Cardiology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, P.R. China.
authors.forename: Tongtong
authors.initials: T
authors.lastname: Yu
authors.affiliation: Department of Cardiology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, P.R. China.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Dong
authors.affiliation: Department of Cardiology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, P.R. China.
authors.forename: Zhijun
authors.initials: Z
authors.lastname: Sun
authors.affiliation: Department of Cardiology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, P.R. China. Electronic address: sunzhaoqing@vip.163.com.
authors.forename: Zhaoqing
authors.initials: Z
authors.lastname: Sun
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D015331:Cohort Studies; D004562:Electrocardiography; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D008297:Male; D063847:Mean Platelet Volume; D008875:Middle Aged; D015999:Multivariate Analysis; D000072658:Non-ST Elevated Myocardial Infarction / Q000097:blood* / Q000401:mortality* / Q000628:therapy; D062645:Percutaneous Coronary Intervention / Q000379:methods* / Q000401:mortality; D010976:Platelet Count; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D018570:Risk Assessment; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric; D017741:Survivors / Q000706:statistics & numerical data*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers
keywords: GRACE score; Long-term prognosis; Mean platelet volume to platelet count ratio; Non-ST-segment elevation myocardial infarction; Percutaneous coronary intervention