title: Intranasal Curcumin Inhibits Pulmonary Fibrosis by Modulating Matrix Metalloproteinase-9 (MMP-9) in Ovalbumin-Induced Chronic Asthma.
abstract: Pulmonary fibrosis is associated with irreversible, or partially reversible, airflow obstruction and ultimately unresponsiveness to asthma therapies such as corticosteroids. Intranasal curcumin, an anti-inflammatory molecule, has been found effective in allergic asthma. To study the effect of intranasal curcumin on airway remodeling and fibrosis in murine model of chronic asthma, BALB/c mice were sensitized to ovalbumin (OVA) and exposed to OVA aerosol (2%) from day 21 (after sensitization) for 5 weeks (twice/week). Curcumin (intranasal) was administered during the OVA aerosol challenge. Mice exposed to OVA developed inflammation dominated by eosinophils which lead to fibrosis and airway remodeling. Intranasal administration of curcumin significantly inhibited airway inflammation and pulmonary fibrosis, where MMP-9 activities were decreased along with α-smooth muscle actin (α-SMA), MMP-9, TIMP-1, and eotaxin expressions. These results suggest that intranasal curcumin regulates airway inflammation and remodeling in chronic asthma.
authors.affiliation: Department of Zoology, MMV Unit, Varanasi, India.
authors.forename: Preeti S
authors.initials: PS
authors.lastname: Chauhan
authors.affiliation: Department of Biochemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, India.
authors.forename: D
authors.initials: D
authors.lastname: Dash
authors.affiliation: Department of Zoology, MMV Unit, Varanasi, India. rashmirs98@rediffmail.com.
authors.forename: Rashmi
authors.initials: R
authors.lastname: Singh
mesh_terms: D000199:Actins / Q000378:metabolism; D000281:Administration, Intranasal; D056151:Airway Remodeling / Q000187:drug effects; D000818:Animals; D001249:Asthma / Q000139:chemically induced / Q000188:drug therapy* / Q000201:enzymology / Q000473:pathology; D002908:Chronic Disease; D003474:Curcumin / Q000008:administration & dosage / Q000494:pharmacology*; D004804:Eosinophils / Q000473:pathology; D007249:Inflammation / Q000188:drug therapy / Q000473:pathology; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism*; D051379:Mice; D010047:Ovalbumin; D011658:Pulmonary Fibrosis / Q000188:drug therapy*; D019715:Tissue Inhibitor of Metalloproteinase-1 / Q000378:metabolism
chemical_list: D000199:Actins; C560825:Timp1 protein, mouse; D019715:Tissue Inhibitor of Metalloproteinase-1; D010047:Ovalbumin; D020780:Matrix Metalloproteinase 9; C501830:Mmp9 protein, mouse; D003474:Curcumin
keywords: airway remodeling; anti-inflammatory; extracellular matrix; fibrosis