title: A 155-dB Dynamic Range Current Measurement Front End for Electrochemical Biosensing.
abstract: An integrated current measurement system with ultra wide dynamic range is presented and fabricated in a 180-nm CMOS technology. Its dual-mode design provides concurrent voltage and frequency outputs, without requiring an external clock source. An integrator-differentiator core provides a voltage output with a noise floor of 11.6 fA/ [Formula: see text] and a -3 dB cutoff frequency of 1.4 MHz. It is merged with an asynchronous current-to-frequency converter, which generates an output frequency linearly proportional to the input current. Together, the voltage and frequency outputs yield a current measurement range of 155 dB, spanning from 204 fA (100 Hz) or 1.25 pA (10 kHz) to 11.6 μA. The proposed architecture's low noise, wide bandwidth, and wide dynamic range make it ideal for measurements of highly nonlinear electrochemical and electrophysiological systems.
authors.forename: Shanshan
authors.initials: S
authors.lastname: Dai
authors.forename: Rukshan T
authors.initials: RT
authors.lastname: Perera
authors.forename: Zi
authors.initials: Z
authors.lastname: Yang
authors.forename: Jacob K
authors.initials: JK
authors.lastname: Rosenstein
mesh_terms: D000669:Amplifiers, Electronic; D015374:Biosensing Techniques / Q000295:instrumentation*; D003217:Conductometry / Q000295:instrumentation*; D003936:Diagnosis, Computer-Assisted / Q000295:instrumentation*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012815:Signal Processing, Computer-Assisted / Q000295:instrumentation*; D059629:Signal-To-Noise Ratio; D018511:Systems Integration