title: Advances in molecular preclinical therapy mediated by imaging.
abstract: Several advances have been made toward understanding the biology of cancer and most of them are due to robust genetic studies that led to the scientific recognition that although many patients have the same type of cancer their tumors may have harbored different molecular alterations. Personalized therapy and the development of advanced techniques of preclinical imaging and new murine models of disease are emerging concepts that are allowing mapping of disease markers in vivo and in some cases also receptor targeted therapy. Aim of this review is to illustrate some emerging models of disease that allow patient tumor implantation in mice for subsequent drug testing and advanced approaches for therapy mediated by preclinical imaging. In particular we discuss targeted therapy mediated by high frequency ultrasound and magnetic resonance, two emerging techniques in molecular preclinical therapy.
authors.affiliation: Department of Advanced Biomedical Science, University of Naples Federico II, Naples, Italy.|Ceinge, Advanced Biotechnology, Scarl, Naples, Italy.|Institute of BioStructures and BioImaging, CNR, Naples, Italy.
authors.forename: Adelaide
authors.initials: A
authors.lastname: Greco
authors.affiliation: Department of Advanced Biomedical Science, University of Naples Federico II, Naples, Italy.|Ceinge, Advanced Biotechnology, Scarl, Naples, Italy.
authors.forename: Sandra
authors.initials: S
authors.lastname: Albanese
authors.affiliation: IRCCS SDN, Naples, Italy.
authors.forename: Luigi
authors.initials: L
authors.lastname: Auletta
authors.affiliation: Department of BioMolecular Sciences, National Center for Natural Products Research, University of Mississippi, Jackson, MS, USA.
authors.forename: Flavia
authors.initials: F
authors.lastname: DE Carlo
authors.affiliation: IRCCS SDN, Naples, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Salvatore
authors.affiliation: Department of Radiology, University of Mississippi Medical Center, Jackson, MS, USA.
authors.forename: Candace M
authors.initials: CM
authors.lastname: Howard
authors.affiliation: Department of BioMolecular Sciences, National Center for Natural Products Research, University of Mississippi, Jackson, MS, USA - pclaudio@olemiss.edu.|Department of Radiation Oncology, Medical Center Cancer Institute, Jackson, MS, USA.
authors.forename: Pier P
authors.initials: PP
authors.lastname: Claudio
mesh_terms: D000818:Animals; D003952:Diagnostic Imaging / Q000379:methods*; D016503:Drug Delivery Systems; D006801:Humans; D009369:Neoplasms / Q000000981:diagnostic imaging* / Q000628:therapy*; D057285:Precision Medicine