title: Omics analysis of mouse brain models of human diseases.
abstract: The identification of common gene/protein profiles related to brain alterations, if they exist, may indicate the convergence of the pathogenic mechanisms driving brain disorders. Six genetically engineered mouse lines modelling neurodegenerative diseases and neuropsychiatric disorders were considered. Omics approaches, including transcriptomic and proteomic methods, were used. The gene/protein lists were used for inter-disease comparisons and further functional and network investigations. When the inter-disease comparison was performed using the gene symbol identifiers, the number of genes/proteins involved in multiple diseases decreased rapidly. Thus, no genes/proteins were shared by all 6 mouse models. Only one gene/protein (Gfap) was shared among 4 disorders, providing strong evidence that a common molecular signature does not exist among brain diseases. The inter-disease comparison of functional processes showed the involvement of a few major biological processes indicating that brain diseases of diverse aetiologies might utilize common biological pathways in the nervous system, without necessarily involving similar molecules.
authors.affiliation: Aix Marseille Univ, CNRS, LNIA, FR3C, Marseille, France. Electronic address: veronique.paban@univ-amu.fr.
authors.forename: Véronique
authors.initials: V
authors.lastname: Paban
authors.affiliation: Aix Marseille Univ, INSERM UMR 1090, TAGC, Marseille, France.
authors.forename: Béatrice
authors.initials: B
authors.lastname: Loriod
authors.affiliation: Aix Marseille Univ, INSERM, CRO2 UMR S911, Faculté de pharmacie, Marseille, France.
authors.forename: Claude
authors.initials: C
authors.lastname: Villard
authors.affiliation: Univ. Lille, Inserm, CHU-Lille, UMR-S 1172, Alzheimer & Tauopathies, Lille, France.
authors.forename: Luc
authors.initials: L
authors.lastname: Buee
authors.affiliation: Univ. Lille, Inserm, CHU-Lille, UMR-S 1172, Alzheimer & Tauopathies, Lille, France.
authors.forename: David
authors.initials: D
authors.lastname: Blum
authors.affiliation: INCIA, Université de Bordeaux, Pessac, France; INCIA, UMR 5287, CNRS, Pessac, France.
authors.forename: Susanna
authors.initials: S
authors.lastname: Pietropaolo
authors.affiliation: INCIA, Université de Bordeaux, Pessac, France; INCIA, UMR 5287, CNRS, Pessac, France.
authors.forename: Yoon H
authors.initials: YH
authors.lastname: Cho
authors.affiliation: INSERM, U1216, Grenoble, France; Univ. Grenoble Alpes, Grenoble Institut Neurosciences, Grenoble, France; CEA, BIG, Grenoble, France.
authors.forename: Sylvie
authors.initials: S
authors.lastname: Gory-Faure
authors.affiliation: Aix Marseille Univ, CNRS, LNIA, FR3C, Marseille, France.
authors.forename: Elodie
authors.initials: E
authors.lastname: Mansour
authors.affiliation: Aix Marseille Univ, CNRS, LNIA, FR3C, Marseille, France.
authors.forename: Ali
authors.initials: A
authors.lastname: Gharbi
authors.affiliation: Aix Marseille Univ, CNRS, LNIA, FR3C, Marseille, France.
authors.forename: Béatrice
authors.initials: B
authors.lastname: Alescio-Lautier
mesh_terms: D000818:Animals; D001522:Behavior, Animal; D001927:Brain Diseases / Q000235:genetics* / Q000378:metabolism*; D004195:Disease Models, Animal; D020869:Gene Expression Profiling; D053263:Gene Regulatory Networks; D023281:Genomics / Q000379:methods*; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000235:genetics / Q000378:metabolism; D053858:Metabolic Networks and Pathways; D051379:Mice; D018345:Mice, Knockout; D008822:Mice, Transgenic; D019636:Neurodegenerative Diseases / Q000235:genetics / Q000378:metabolism; D040901:Proteomics / Q000379:methods*
keywords: Amyloidosis; Autism; Huntington; Network; Parkinson; Proteomic; Schizophrenia; Tauopathy; Transcriptomic