title: Allium sativum Compared to Cilostazol as an Inhibitor of Myointimal Hyperplasia.
abstract: Intimal hyperplasia is associated with graft failure and vascular sutures in the first year after surgery and in postangioplasty restenosis. Allium sativum (common garlic) lowers cholesterol and has antioxidant effects; it also has antiplatelet and antitumor properties and, therefore, has great potential to reduce or inhibit intimal hyperplasia of the arteries. Our objective is to determine if the garlic has an efficacy to inhibit myointimal hyperplasia compared to cilostazol.
  
  
  
  Female New Zealand rabbits were divided into the following groups (n=10 each) according to treatment: group A, garlic, 800 µg×kg-1×day-1, orally; group C, cilostazol, 50 mg.day-1, orally; group PS, 10 ml of 0.9% physiological saline solution, orally. Our primary is the difference of the mean of myointimal hyperplasia. Statistical analysis was performed by using ANOVA and Tukey tests, as well as the Chi-square test. We calculated the 95% confidence interval for each point estimate, and the P value was set as < 0.05.
  
  
  
  Group PS had a mean hyperplasia rate of 35.74% (95% CI, 31.76-39.71%); group C, 16.21% (95% CI, 13.36-19.05%); and group A, 21.12% (95% CI, 17.26-25.01%); P <  0.0001.
  
  
  
  We conclude that Allium sativum had the same efficacy in inhibiting myointimal hyperplasia when compared to the positive control, cilostazol.
authors.affiliation: Federal University of Alagoas (UFAL), Maceió, AL, Brazil and Centro de Angiologia e Cirurgia Vascular (Ceangio), João Pessoa, PB, Brazil.
authors.forename: Paulo Roberto da Silva
authors.initials: PR
authors.lastname: Lima
authors.affiliation: Department of Surgery of the Federal University of Paraíba (UFPB), João Pessoa, PB, Brazil.
authors.forename: Francisco Chavier Vieira
authors.initials: FC
authors.lastname: Bandeira
authors.affiliation: Vascular surgery in the Emergency Hospital and Trauma Dom Luiz Gonzaga Fernandes, Campina Grande, PB, Brazil.
authors.forename: Janio Cipriano
authors.initials: JC
authors.lastname: Rolim
authors.affiliation: Department of Surgery of the Federal University of Paraíba (UFPB), João Pessoa, PB, Brazil.
authors.forename: Manuel Ricardo Sena
authors.initials: MR
authors.lastname: Nogueira
authors.affiliation: Vascular surgery in the Emergency Hospital and Trauma Dom Luiz Gonzaga Fernandes, Campina Grande, PB, Brazil.
authors.forename: Mizael Armando Abrantes
authors.initials: MA
authors.lastname: Pordeus
authors.affiliation: Federal University of Paraíba (UFPB), João Pessoa, PB, Brazil.
authors.forename: Andressa Feitosa Bezerra
authors.initials: AFB
authors.lastname: de Oliveira
authors.affiliation: Universidade Estadual de Ciências da Saúde de Alagoas (UNCISAL), Maceió, AL, Brazil.
authors.forename: Guilherme Benjamin Brandão
authors.initials: GB
authors.lastname: Pitta
mesh_terms: D000818:Animals; D001161:Arteriosclerosis / Q000473:pathology / Q000517:prevention & control*; D000077407:Cilostazol; D005260:Female; D005737:Garlic / Q000737:chemistry*; D006965:Hyperplasia / Q000517:prevention & control; D007150:Immunohistochemistry; D010975:Platelet Aggregation Inhibitors; D011817:Rabbits; D013777:Tetrazoles / Q000494:pharmacology*; D017539:Tunica Intima / Q000473:pathology*
chemical_list: D010975:Platelet Aggregation Inhibitors; D013777:Tetrazoles; D000077407:Cilostazol