title: Aspergillus in chronic lung disease: Modeling what goes on in the airways.
abstract: Aspergillus species cause a range of respiratory diseases in humans. While immunocompromised patients are at risk for the development of invasive infection with these opportunistic molds, patients with underlying pulmonary disease can develop chronic airway infection with Aspergillus species. These conditions span a range of inflammatory and allergic diseases including Aspergillus bronchitis, allergic bronchopulmonary aspergillosis, and severe asthma with fungal sensitization. Animal models are invaluable tools for the study of the molecular mechanism underlying the colonization of airways by Aspergillus and the host response to these non-invasive infections. In this review we summarize the state-of-the-art with respect to the available animal models of noninvasive and allergic Aspergillus airway disease; the key findings of host-pathogen interaction studies using these models; and the limitations and future directions that should guide the development and use of models for the study of these important pulmonary conditions.
authors.affiliation: Departments of Medicine, Microbiology and Immunology, McGill University, Montréal, Québec, Canada.|Department of Infectious Diseases, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.|Infectious Diseases and Immunity in Global Health Program, Research Institute of the McGill University Health Centre, Montréal, Québec, Canada.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Takazono
authors.affiliation: Departments of Medicine, Microbiology and Immunology, McGill University, Montréal, Québec, Canada don.sheppard@mcgill.ca.|Infectious Diseases and Immunity in Global Health Program, Research Institute of the McGill University Health Centre, Montréal, Québec, Canada.
authors.forename: Donald C
authors.initials: DC
authors.lastname: Sheppard
mesh_terms: D000818:Animals; D001230:Aspergillus / Q000276:immunology* / Q000472:pathogenicity*; D002908:Chronic Disease; D004195:Disease Models, Animal; D054884:Host-Pathogen Interactions; D006801:Humans; D055732:Pulmonary Aspergillosis / Q000276:immunology / Q000382:microbiology* / Q000473:pathology*
keywords: Aspergillus bronchitis; Aspergillus induced airway diseases; allergic bronchopulmonary aspergillosis; animal model; colonization