title: NCOA5 is correlated with progression and prognosis in luminal breast cancer.
abstract: Nuclear receptor coactivator 5 (NCOA5) is known to modulate ERα-mediated transcription and has been found to be involved in the progression of several malignancies. However, the potential correlation between NCOA5 and clinical outcome in patients with luminal breast cancer remains unknown. In the present study, we demonstrated that NCOA5 was significantly up-regulated in luminal breast cancer tissues compared with adjacent non-cancerous tissues both in validated cohort and TCGA cohort. Moreover, Kaplan-Meier analysis indicated that patients with high NOCA5 expression had significantly lower overall survival (P = 0.021). Cox regression analysis indicated that the high NOCA5 expression was independent high risk factor as well as old age (>60) and HER-2 expression (P = 0.039; P = 0.003; P = 0.005; respectively). This study provides new insights and evidences that NOCA5 over-expression was significantly correlated with progression and prognosis in luminal breast cancer. However, the precise cellular mechanisms for NOCA5 in luminal breast cancer need to be further explored.
authors.affiliation: Department of Radiology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejian, PR China. Electronic address: 13989765788@163.com.
authors.forename: Xiao-He
authors.initials: XH
authors.lastname: Ye
authors.affiliation: Department of Oncology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejian, PR China. Electronic address: oncology2004@163.com.
authors.forename: Du-Ping
authors.initials: DP
authors.lastname: Huang
authors.affiliation: Cancer Centre, TCM-Integrated Hospital of Southern Medical University, Guangzhou, Guangdong, PR China. Electronic address: oncology201716@163.com.
authors.forename: Rong-Cheng
authors.initials: RC
authors.lastname: Luo
mesh_terms: D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism*; D001943:Breast Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000401:mortality*; D002681:China / Q000453:epidemiology; D018450:Disease Progression; D005260:Female; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D056918:Nuclear Receptor Coactivators / Q000378:metabolism*; D011379:Prognosis; D015203:Reproducibility of Results; D012307:Risk Factors; D012680:Sensitivity and Specificity; D013223:Statistics as Topic; D015996:Survival Rate
chemical_list: D014408:Biomarkers, Tumor; C418222:NCOA5 protein, human; D056918:Nuclear Receptor Coactivators
keywords: Luminal breast cancer; NCOA5; Prognosis