title: Effects of Reynolds and Womersley Numbers on the Hemodynamics of Intracranial Aneurysms.
abstract: The effects of Reynolds and Womersley numbers on the hemodynamics of two simplified intracranial aneurysms (IAs), that is, sidewall and bifurcation IAs, and a patient-specific IA are investigated using computational fluid dynamics. For this purpose, we carried out three numerical experiments for each IA with various Reynolds (Re = 145.45 to 378.79) and Womersley (Wo = 7.4 to 9.96) numbers. Although the dominant flow feature, which is the vortex ring formation, is similar for all test cases here, the propagation of the vortex ring is controlled by both Re and Wo in both simplified IAs (bifurcation and sidewall) and the patient-specific IA. The location of the vortex ring in all tested IAs is shown to be proportional to Re/Wo2which is in agreement with empirical formulations for the location of a vortex ring in a tank. In sidewall IAs, the oscillatory shear index is shown to increase with Wo and 1/Re because the vortex reached the distal wall later in the cycle (higher resident time). However, this trend was not observed in the bifurcation IA because the stresses were dominated by particle trapping structures, which were absent at low Re = 151.51 in contrast to higher Re = 378.79.
authors.affiliation: Department of Mechanical and Aerospace Engineering, University at Buffalo, The State University of New York, Buffalo, NY, USA.
authors.forename: Hafez
authors.initials: H
authors.lastname: Asgharzadeh
authors.affiliation: Department of Mechanical and Aerospace Engineering, University at Buffalo, The State University of New York, Buffalo, NY, USA.
authors.forename: Iman
authors.identifier: 0000-0001-7940-3168
authors.initials: I
authors.lastname: Borazjani
mesh_terms: D000465:Algorithms; D001696:Biomechanical Phenomena; D001783:Blood Flow Velocity; D003198:Computer Simulation; D006439:Hemodynamics; D018056:Hemorheology; D006801:Humans; D057446:Hydrodynamics; D021621:Imaging, Three-Dimensional; D002532:Intracranial Aneurysm / Q000175:diagnosis* / Q000503:physiopathology*; D008955:Models, Cardiovascular; D008962:Models, Theoretical; D009991:Oscillometry; D011673:Pulsatile Flow; D012984:Software; D013314:Stress, Mechanical