title: Preventive Intra Oral Treatment of Sea Cucumber Ameliorate OVA-Induced Allergic Airway Inflammation.
abstract: Sea cucumber extracts have potent biological effects, including anti-viral, anti-cancer, antibacterial, anti-oxidant, and anti-inflammation effects. To understand their anti-asthma effects, we induced allergic airway inflammation in mice after 7 oral administrations of the extract. The hyper-responsiveness value in mice with ovalbumin (OVA)-alum-induced asthma after oral injection of sea cucumber extracts was significantly lower than that in the OVA-alum-induced asthma group. In addition, the number of eosinophils in the lungs of asthma-induced mice pre-treated with sea cucumber extract was significantly decreased compared to that of PBS pre-treated mice. Additionally, CD4[Formula: see text]CD25[Formula: see text]Foxp3[Formula: see text]T (regulatory T; Treg) cells significantly increased in mesenteric lymph nodes after 7 administrations of the extract. These results suggest that sea cucumber extract can ameliorate allergic airway inflammation via Treg cell activation and recruitment to the lung.
authors.affiliation: * Department of Parasitology, School of Medicine, Pusan National University, Yangsan-si, Gyeongsangnam-do 626-870, Republic of Korea.|† Immunoregulatory Therapeutics Group in Brain Busan 21 Project, Gyeonsang National University, Tongyeong 650-160, Republic of Korea.
authors.forename: Da-In
authors.initials: DI
authors.lastname: Lee
authors.affiliation: * Department of Parasitology, School of Medicine, Pusan National University, Yangsan-si, Gyeongsangnam-do 626-870, Republic of Korea.|† Immunoregulatory Therapeutics Group in Brain Busan 21 Project, Gyeonsang National University, Tongyeong 650-160, Republic of Korea.
authors.forename: Mi-Kyung
authors.initials: MK
authors.lastname: Park
authors.affiliation: * Department of Parasitology, School of Medicine, Pusan National University, Yangsan-si, Gyeongsangnam-do 626-870, Republic of Korea.|† Immunoregulatory Therapeutics Group in Brain Busan 21 Project, Gyeonsang National University, Tongyeong 650-160, Republic of Korea.
authors.forename: Shin Ae
authors.initials: SA
authors.lastname: Kang
authors.affiliation: * Department of Parasitology, School of Medicine, Pusan National University, Yangsan-si, Gyeongsangnam-do 626-870, Republic of Korea.|† Immunoregulatory Therapeutics Group in Brain Busan 21 Project, Gyeonsang National University, Tongyeong 650-160, Republic of Korea.
authors.forename: Jun-Ho
authors.initials: JH
authors.lastname: Choi
authors.affiliation: ‡ Department of Marine Biology and Aquaculture, Gyeonsang National University, Tongyeong 650-160, Republic of Korea.
authors.forename: Seok-Jung
authors.initials: SJ
authors.lastname: Kang
authors.affiliation: § S-J Bio Company, Tongyeong 53084, Republic of Korea.
authors.forename: Jeong-Yeol
authors.initials: JY
authors.lastname: Lee
authors.affiliation: * Department of Parasitology, School of Medicine, Pusan National University, Yangsan-si, Gyeongsangnam-do 626-870, Republic of Korea.
authors.forename: Hak Sun
authors.initials: HS
authors.lastname: Yu
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000893:Anti-Inflammatory Agents; D001249:Asthma / Q000276:immunology / Q000517:prevention & control*; D004195:Disease Models, Animal; D004804:Eosinophils / Q000276:immunology; D005260:Female; D008168:Lung / Q000276:immunology; D008198:Lymph Nodes / Q000276:immunology; D008810:Mice, Inbred C57BL; D010047:Ovalbumin / Q000276:immunology; D012616:Sea Cucumbers / Q000737:chemistry*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D014020:Tissue Extracts / Q000008:administration & dosage* / Q000494:pharmacology
chemical_list: D000893:Anti-Inflammatory Agents; D014020:Tissue Extracts; D010047:Ovalbumin
keywords: Allergic Airway Inflammation; Anti-Inflammation; Oral Administration; Regulatory T Cells; Sea Cucumber