title: Needleless coaxial electrospinning: A novel approach to mass production of coaxial nanofibers.
abstract: Herein, we describe a simple spinneret setup for needleless coaxial electrospinning that exceeds the limited production capacity of current approaches. The proposed weir spinneret enables coaxial electrospinning from free liquid surface. This approach leads to the formation of coaxial nanofibers with higher and uniform shell/core ratio, which results in the possibility of better tuning of the degradation rate. The throughput and quality increase favor the broader application of coaxial nanofibers from weir spinnerets as systems for controlled drug delivery in regenerative medicine and tissue engineering.
authors.affiliation: Department of Nonwovens, Technical University of Liberec Studentska 2, 461 17 Liberec, Czechia.
authors.forename: Lucie
authors.initials: L
authors.lastname: Vysloužilová
authors.affiliation: Department of Biophysics, 2nd Faculty of Medicine, Charles University in Prague, V Úvalu 84, 150 06, Prague 5, Czechia; Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, v.v.i., Vídeňská 1083, 142 20, Prague 4, Czechia; University Centre for Energy Efiicient Buildings, Czech Technical University in Prague, Trinecka 1024, 273 43, Bustehrad, Czechia. Electronic address: buzgo@labdemo.cz.
authors.forename: Matej
authors.initials: M
authors.lastname: Buzgo
authors.affiliation: Department of Nonwovens, Technical University of Liberec Studentska 2, 461 17 Liberec, Czechia.
authors.forename: Pavel
authors.initials: P
authors.lastname: Pokorný
authors.affiliation: Department of Nonwovens, Technical University of Liberec Studentska 2, 461 17 Liberec, Czechia.
authors.forename: Jiří
authors.initials: J
authors.lastname: Chvojka
authors.affiliation: Department of Biophysics, 2nd Faculty of Medicine, Charles University in Prague, V Úvalu 84, 150 06, Prague 5, Czechia; Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, v.v.i., Vídeňská 1083, 142 20, Prague 4, Czechia; University Centre for Energy Efiicient Buildings, Czech Technical University in Prague, Trinecka 1024, 273 43, Bustehrad, Czechia.
authors.forename: Andrea
authors.initials: A
authors.lastname: Míčková
authors.affiliation: Department of Biophysics, 2nd Faculty of Medicine, Charles University in Prague, V Úvalu 84, 150 06, Prague 5, Czechia; Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, v.v.i., Vídeňská 1083, 142 20, Prague 4, Czechia; University Centre for Energy Efiicient Buildings, Czech Technical University in Prague, Trinecka 1024, 273 43, Bustehrad, Czechia.
authors.forename: Michala
authors.initials: M
authors.lastname: Rampichová
authors.affiliation: Department of Textile Evaluation, Technical University of Liberec, Studentska 2, 461 17 Liberec, Czechia.
authors.forename: Jiří
authors.initials: J
authors.lastname: Kula
authors.affiliation: Department of Textile Machine Design, Technical University of Liberec, Studentska 2, 461 17 Liberec, Czechia.
authors.forename: Karel
authors.initials: K
authors.lastname: Pejchar
authors.affiliation: Department of Textile Machine Design, Technical University of Liberec, Studentska 2, 461 17 Liberec, Czechia.
authors.forename: Martin
authors.initials: M
authors.lastname: Bílek
authors.affiliation: Department of Nonwovens, Technical University of Liberec Studentska 2, 461 17 Liberec, Czechia.
authors.forename: David
authors.initials: D
authors.lastname: Lukáš
authors.affiliation: Department of Biophysics, 2nd Faculty of Medicine, Charles University in Prague, V Úvalu 84, 150 06, Prague 5, Czechia; Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, v.v.i., Vídeňská 1083, 142 20, Prague 4, Czechia; University Centre for Energy Efiicient Buildings, Czech Technical University in Prague, Trinecka 1024, 273 43, Bustehrad, Czechia.
authors.forename: Evžen
authors.initials: E
authors.lastname: Amler
mesh_terms: D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems; D006801:Humans; D057139:Nanofibers; D044968:Regenerative Medicine / Q000379:methods; D013678:Technology, Pharmaceutical / Q000379:methods*; D023822:Tissue Engineering / Q000379:methods
chemical_list: D003692:Delayed-Action Preparations
keywords: Coaxial electrospinning; Core-shell nanofibers; Fluorescent spectroscopy; Needleless electrospinning