title: CDH13 gene-by-PM10interaction effect on lung function decline in Korean men.
abstract: Lung function can be influenced by genetic factors, which may explain individual differences in susceptibility to the effects of air pollution. This study investigated whether the effect of particulate matter with an aerodynamic diameter ≤10 μm (PM10) on lung function is modified by Cadherin 13 (CDH13) genetic variants in Korean men. This study included a total of 1827 men who were recruited from two health check-up centers, and the annual average PM10concentrations were used. A total of 200 single-nucleotide polymorphisms (SNPs) of the CDH13 gene were selected for this study. We found that a SNP in CHD13 intron, rs1862830, had the strongest associations with both forced expiratory volume in 1 s (FEV1) (pint= 1.90 × 10-4) and forced vital capacity (FVC) (pint= 1.88 × 10-3) by interacting with PM10in a recessive model. A stratified association analysis according to this SNP showed that PM10in the AG or GG genotype group was not significantly associated with either FEV1or FVC, whereas in homozygous risk-allele carriers (AA), FEV1and FVC decreased significantly (by 3.8% and 3.1%, respectively) per 10 μg/m3of increase in PM10concentration. This pattern was also reproducible in the independent subgroups that were classified according to recruitment site. The present study replicated the CDH13 gene-by-PM10interaction effect on lung function at the gene level, revealing that a genetic variant of CDH13 modified the relationship between PM10and lung function decline in Korean men.
authors.affiliation: Institute of Health and Environment, Seoul National University, Seoul 08826, South Korea.
authors.forename: Hyun-Jin
authors.initials: HJ
authors.lastname: Kim
authors.affiliation: Institute of Health and Environment, Seoul National University, Seoul 08826, South Korea.
authors.forename: Jin-Young
authors.initials: JY
authors.lastname: Min
authors.affiliation: Department of Preventive Medicine, College of Medicine, Seoul National University, Seoul 03080, South Korea.
authors.forename: Kyoung-Bok
authors.initials: KB
authors.lastname: Min
authors.affiliation: Institute of Health and Environment, Seoul National University, Seoul 08826, South Korea.
authors.forename: Yong-Seok
authors.initials: YS
authors.lastname: Seo
authors.affiliation: Institute of Health and Environment, Seoul National University, Seoul 08826, South Korea.
authors.forename: Joohon
authors.initials: J
authors.lastname: Sung
authors.affiliation: Department of Family Medicine, Seoul National University Hospital, Seoul 03080, South Korea.
authors.forename: Jae Moon
authors.initials: JM
authors.lastname: Yun
authors.affiliation: Department of Family Medicine, Seoul National University Hospital, Seoul 03080, South Korea.
authors.forename: Hyuktae
authors.initials: H
authors.lastname: Kwon
authors.affiliation: Department of Family Medicine, Seoul National University Hospital, Seoul 03080, South Korea.
authors.forename: Belong
authors.initials: B
authors.lastname: Cho
authors.affiliation: Department of Family Medicine, Seoul National University Hospital, Seoul 03080, South Korea. Electronic address: kkolzzi0@gmail.com.
authors.forename: Jin-Ho
authors.initials: JH
authors.lastname: Park
authors.affiliation: Department of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul 03080, South Korea; Department of Biomedical Sciences, Seoul National University Graduate School, Seoul 03080, South Korea. Electronic address: jongil@snu.ac.kr.
authors.forename: Jong-Il
authors.initials: JI
authors.lastname: Kim
mesh_terms: D000328:Adult; D000393:Air Pollutants / Q000032:analysis*; D015820:Cadherins / Q000235:genetics*; D005541:Forced Expiratory Volume / Q000235:genetics*; D059647:Gene-Environment Interaction; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D010316:Particle Size; D052638:Particulate Matter / Q000032:analysis*; D020641:Polymorphism, Single Nucleotide; D056910:Republic of Korea
chemical_list: D000393:Air Pollutants; D015820:Cadherins; C099972:H-cadherin; D052638:Particulate Matter
keywords: Air pollution; CDH13; Gene-environment interaction; Korean men; Lung function