title: Outcomes in childhood following therapeutic hypothermia for neonatal hypoxic-ischemic encephalopathy (HIE).
abstract: In this article, we review the childhood outcomes of neonates with birth depression and/or hypoxic-ischemic encephalopathy. The outcomes of these children prior to the era of hypothermia for neuroprotection will first be summarized, followed by discussion of results from randomized controlled trials of therapeutic hypothermia for neonatal hypoxic-ischemic encephalopathy. The predictors of outcome in childhood following neonatal HIE using clinical and imaging biomarkers following hypothermia therapy will be described.
authors.affiliation: Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI.
authors.forename: Girija
authors.initials: G
authors.lastname: Natarajan
authors.affiliation: Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI.
authors.forename: Athina
authors.initials: A
authors.lastname: Pappas
authors.affiliation: Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI. Electronic address: sshankar@med.wayne.edu.
authors.forename: Seetha
authors.initials: S
authors.lastname: Shankaran
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D001034:Apgar Score; D001219:Aspartate Aminotransferases / Q000097:blood; D001238:Asphyxia Neonatorum / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy*; D015415:Biomarkers / Q000097:blood; D002648:Child; D003404:Creatinine / Q000097:blood; D002658:Developmental Disabilities / Q000503:physiopathology* / Q000517:prevention & control; D004185:Disability Evaluation; D006801:Humans; D007036:Hypothermia, Induced / Q000379:methods; D020925:Hypoxia-Ischemia, Brain / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy*; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy*; D008279:Magnetic Resonance Imaging; D009460:Neurologic Examination; D017063:Outcome Assessment, Health Care; D016032:Randomized Controlled Trials as Topic; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers; D003404:Creatinine; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase