title: Vitamin D supplementation affects the IGF system in men after acute exercise.
abstract: Contradictory data between the Insulin-Like Growth Factor System (IGF) system and exercise may be due to alteration in IGF binding proteins. Vitamin D (D) deficiency has been related to muscle weakness and Insulin Like Growth Factor Binding Protein 3 (IGFBP3). A Vit. D and acute exercise merge is proposed to modify the IGF system.
  
  
  
  D insufficient and deficient men (39.0±8.6yo with serum D (25OH D) 20.0±7.7ng/mL) did 1h of stretching (ST), aerobic (AB), and resistance (RT) exercises, before and after 28d of 4000IU/d Vit. D3 (D, n=6) or Placebo (P, n=7). ST, a time/attention control visit, interchanged unreceptive movements. AB was moderate intensity treadmill walking. RT rotated moderate strength 50% 1-RM repetitions (15, 10) of squat, bench press, leg press, and lat pull down. Serum Total IGF1 (TIGF1), Insulin Like Growth Factor Binding Protein 1 (IGFBP1), and IGFBP3 were measured before (T1, fasting), immediately after (T2), and 2h post (T3) exercise.
  
  
  
  After ST, IGFBP3 was greater in the D group at T2 (2948, 2130ng/mL; p<0.03) and T3 (3087, 2212; p<0.02). During RT, TIGF1 decreased in the Placebo (P) group from T1 to T3 (151.4, 107.3ng/mL; p<0.05), while IGFBP1 increased in the D group from T1 to T3 (26.5, 96.2ng/mL; p<0.05). RT IGFBP3 was greater at T1, T2, and T3 in the D group (2932.5, 2110.7; p<0.03), (3163.9, 2392.5; p<0.04), and (3355.3, 2353.1; p<0.01). In AB, IGFBP3 was greater in the D group at T2 (3128.6, 2226.3.0; p<0.04) and T3 (2949.7, 2135.1; p<0.05).
  
  
  
  D supplementation amplified IGFBP3 after low or moderate activity which may increase the delivery of IGF1 to tissues. Resistance exercise with D not only increased IGFBP3 and IGFBP1 levels but also conserved TIGF1 levels, possibly shifting the IGF system for enriched muscle well-being.
authors.affiliation: Department of Kinesiology, Saginaw Valley State University, University Center, GN205 7400 Bay Rd. University Center, MI 48710, USA; Department of Exercise and Nutrition Sciences, University at Buffalo, Buffalo, NY, USA. Electronic address: rldarr@svsu.edu.
authors.forename: Rachel L
authors.initials: RL
authors.lastname: Darr
authors.affiliation: Department of Biology, St. John Fisher College, ISHS 212 3690 East Avenue, Rochester, NY 14618, USA. Electronic address: ksavage@sjfc.edu.
authors.forename: Kathleen J
authors.initials: KJ
authors.lastname: Savage
authors.affiliation: Department of Biostatistics, University at Buffalo, B1148 Center for Tomorrow, Amherst, Buffalo, NY 14260, USA. Electronic address: markbake@buffalo.edu.
authors.forename: Mark
authors.initials: M
authors.lastname: Baker
authors.affiliation: Department of Biostatistics, University at Buffalo, B1148 Center for Tomorrow, Amherst, Buffalo, NY 14260, USA. Electronic address: gwilding@buffalo.edu.
authors.forename: Gregory E
authors.initials: GE
authors.lastname: Wilding
authors.affiliation: Department of Exercise and Nutrition Sciences, University at Buffalo, 3435 Main St. Buffalo, NY 14214, USA. Electronic address: ajr24@buffalo.edu.
authors.forename: Amy
authors.initials: A
authors.lastname: Raswalsky
authors.affiliation: Department of Exercise and Nutrition Sciences, University at Buffalo, 3435 Main St. Buffalo, NY 14214, USA. Electronic address: rideout@buffalo.edu.
authors.forename: Todd
authors.initials: T
authors.lastname: Rideout
authors.affiliation: Department of Biotechnical and Clinical Laboratory Sciences, University at Buffalo, 26 Cary Hall, Buffalo, NY 14214, USA. Electronic address: rwbrowne@buffalo.edu.
authors.forename: Richard W
authors.initials: RW
authors.lastname: Browne
authors.affiliation: Department of Exercise and Nutrition Sciences, University at Buffalo, Buffalo, NY, USA. Electronic address: phorvath@buffalo.edu.
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Horvath
mesh_terms: D000328:Adult; D002762:Cholecalciferol / Q000627:therapeutic use*; D019587:Dietary Supplements; D015444:Exercise; D006801:Humans; D018970:Insulin-Like Growth Factor Binding Protein 1 / Q000378:metabolism*; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000378:metabolism*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D052580:Muscle Stretching Exercises; D055070:Resistance Training; D014807:Vitamin D / Q000031:analogs & derivatives / Q000378:metabolism; D014808:Vitamin D Deficiency / Q000188:drug therapy* / Q000378:metabolism; D014815:Vitamins / Q000627:therapeutic use*
chemical_list: C583557:IGF1 protein, human; C032231:IGFBP1 protein, human; C515497:IGFBP3 protein, human; D018970:Insulin-Like Growth Factor Binding Protein 1; D018972:Insulin-Like Growth Factor Binding Protein 3; D014815:Vitamins; D014807:Vitamin D; D002762:Cholecalciferol; D007334:Insulin-Like Growth Factor I; C104450:25-hydroxyvitamin D
keywords: Aerobic exercise; IGFBP1; IGFBP3; Nutrition; Resistance exercise; Total IGF1