title: Dimeric sesquiterpene and thiophenes from the roots of Echinops latifolius.
abstract: Phytochemical investigation of the roots of Echinops latifolius led to the isolation of a new carbon skeleton dimeric sesquiterpene (1) and a new thiophene (2), along with six known compounds (3-8). Their structures and relative stereochemistry were elucidated by spectroscopic and spectrometric methods (1H and13C NMR, COSY, HSQC, HMBC, ROESY, and MS). All isolates were evaluated for their inhibition of LPS-induced NO production in RAW 264.7 cells. Compounds 4 and 5 exhibited the most potent inhibitory effects on NO production.
authors.affiliation: College of Pharmacy, Chungbuk National University, Cheongju 28644, Republic of Korea; Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture, Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan 430074, China.
authors.forename: Qinghao
authors.initials: Q
authors.lastname: Jin
authors.affiliation: College of Pharmacy, Chungbuk National University, Cheongju 28644, Republic of Korea.
authors.forename: Jin Woo
authors.initials: JW
authors.lastname: Lee
authors.affiliation: College of Pharmacy, Chungbuk National University, Cheongju 28644, Republic of Korea.
authors.forename: Hari
authors.initials: H
authors.lastname: Jang
authors.affiliation: College of Pharmacy, Chungbuk National University, Cheongju 28644, Republic of Korea.
authors.forename: Ji Eun
authors.initials: JE
authors.lastname: Choi
authors.affiliation: College of Pharmacy, Chungbuk National University, Cheongju 28644, Republic of Korea.
authors.forename: Hyung Sik
authors.initials: HS
authors.lastname: Kim
authors.affiliation: College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea.
authors.forename: Dongho
authors.initials: D
authors.lastname: Lee
authors.affiliation: College of Pharmacy, Chungbuk National University, Cheongju 28644, Republic of Korea.
authors.forename: Jin Tae
authors.initials: JT
authors.lastname: Hong
authors.affiliation: College of Pharmacy, Chungbuk National University, Cheongju 28644, Republic of Korea.
authors.forename: Mi Kyeong
authors.initials: MK
authors.lastname: Lee
authors.affiliation: College of Pharmacy, Chungbuk National University, Cheongju 28644, Republic of Korea. Electronic address: byhwang@chungbuk.ac.kr.
authors.forename: Bang Yeon
authors.initials: BY
authors.lastname: Hwang
mesh_terms: D000818:Animals; D019281:Dimerization; D004305:Dose-Response Relationship, Drug; D031182:Echinops Plant / Q000737:chemistry*; D008070:Lipopolysaccharides / Q000037:antagonists & inhibitors / Q000494:pharmacology; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D018517:Plant Roots / Q000737:chemistry*; D000067996:RAW 264.7 Cells; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013876:Thiophenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D008070:Lipopolysaccharides; D012717:Sesquiterpenes; D013876:Thiophenes; D009569:Nitric Oxide
keywords: Anti-inflammatory; Asteraceae; Dimeric sesquiterpene; Echinops latifolius; Thiophene