title: "On water" reaction of deactivated anilines with 4-methoxy-3-buten-2-one, an effective butynone surrogate.
abstract: Poorly nucleophilic aromatic amines (nitroanilines, chloroanilines, etc.) react readily and selectively with trans-4-methoxy-3-buten-2-one, a convenient, effective and inexpensive surrogate for 3-butyn-2-one, to afford (Z)-enaminones. The efficiency of the reaction mostly lies in the use of water as a solvent, which enhances the reaction rate by a 45 to 200-fold factor with regard to other media.
authors.affiliation: Normandie Univ., INSA Rouen, UNIROUEN, CNRS, COBRA, 76000 Rouen, France and Université de Tunis El Manar, Faculté des Sciences de Tunis, Laboratoire de Chimie Organique Structurale LR99ES14, Campus Universitaire, 2092 Tunis, Tunisia. julien.legros@univ-rouen.fr.
authors.forename: Meriam
authors.initials: M
authors.lastname: Jebari
authors.affiliation: Normandie Univ., INSA Rouen, UNIROUEN, CNRS, COBRA, 76000 Rouen, France.
authors.forename: Karine
authors.initials: K
authors.lastname: Pasturaud
authors.affiliation: Normandie Univ., INSA Rouen, UNIROUEN, CNRS, COBRA, 76000 Rouen, France.
authors.forename: Baptiste
authors.initials: B
authors.lastname: Picard
authors.affiliation: Normandie Univ., INSA Rouen, UNIROUEN, CNRS, COBRA, 76000 Rouen, France.
authors.forename: Jacques
authors.identifier: http://orcid.org/0000-0001-8623-0533
authors.initials: J
authors.lastname: Maddaluno
authors.affiliation: Université de Tunis El Manar, Faculté des Sciences de Tunis, Laboratoire de Chimie Organique Structurale LR99ES14, Campus Universitaire, 2092 Tunis, Tunisia. julien.legros@univ-rouen.fr.
authors.forename: Farhat
authors.initials: F
authors.lastname: Rezgui
authors.affiliation: Normandie Univ., INSA Rouen, UNIROUEN, CNRS, COBRA, 76000 Rouen, France.
authors.forename: Isabelle
authors.identifier: http://orcid.org/0000-0001-6302-7831
authors.initials: I
authors.lastname: Chataigner
authors.affiliation: Normandie Univ., INSA Rouen, UNIROUEN, CNRS, COBRA, 76000 Rouen, France.
authors.forename: Julien
authors.initials: J
authors.lastname: Legros