title: Feasibility and effects of a decision aid about fertility preservation.
abstract: This paper reports on the feasibility and preliminary effects of a decision aid (DA) about female fertility preservation (FP). We conducted a pilot multicentre randomized controlled trial of women with breast cancer aged 18-40 who were randomized to brochures or the DA. Over 18 months, 62 women were eligible, of which 42 were invited by their healthcare provider (74%) to participate in the study. A total of 36 women signed up for participation and 26 (72%) were randomized to brochures (n = 13) or the DA (n = 13). In both groups, many women (87%) read the brochures and eight women used all available brochures. In the intervention group, 7/13 women logged in to the DA. Women who received brochures had slightly less decisional conflict, whereas knowledge improved in both groups. Our results indicate that both brochures about FP and a detailed DA have beneficial effects with regard to knowledge, but the DA seemed to introduce slightly more decisional conflict (DC) than the brochures. Although we encountered challenges with recruitment, our design and measurements seem feasible and the effects of the information materials seem promising, hence justifying conducting a larger study.
authors.affiliation: a Department of Gynaecology , Leiden University Medical Centre , Leiden , The Netherlands.
authors.forename: Mirjam M
authors.initials: MM
authors.lastname: Garvelink
authors.affiliation: a Department of Gynaecology , Leiden University Medical Centre , Leiden , The Netherlands.
authors.forename: Moniek M
authors.initials: MM
authors.lastname: Ter Kuile
authors.affiliation: a Department of Gynaecology , Leiden University Medical Centre , Leiden , The Netherlands.
authors.forename: Leoni A
authors.initials: LA
authors.lastname: Louwé
authors.affiliation: b Department of Gynaecology , Reinier de Graaf Hospital , Delft , The Netherlands.
authors.forename: Carina G J M
authors.initials: CGJM
authors.lastname: Hilders
authors.affiliation: c Department of Medical Decision Making , Leiden University Medical Centre , Leiden , The Netherlands.
authors.forename: Anne M
authors.initials: AM
authors.lastname: Stiggelbout
mesh_terms: D000293:Adolescent; D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy*; D003220:Conflict, Psychological; D003657:Decision Making; D003661:Decision Support Techniques; D005260:Female; D005298:Fertility / Q000187:drug effects*; D059247:Fertility Preservation; D006801:Humans; D010353:Patient Education as Topic / Q000379:methods*; D010865:Pilot Projects; D055815:Young Adult
chemical_list: D000970:Antineoplastic Agents
keywords: Fertility preservation; cancer; decision aid; decisional conflict; knowledge