title: Numerical simulation of volume-controlled mechanical ventilated respiratory system with 2 different lungs.
abstract: Mechanical ventilation is a key therapy for patients who cannot breathe adequately by themselves, and dynamics of mechanical ventilation system is of great significance for life support of patients. Recently, models of mechanical ventilated respiratory system with 1 lung are used to simulate the respiratory system of patients. However, humans have 2 lungs. When the respiratory characteristics of 2 lungs are different, a single-lung model cannot reflect real respiratory system. In this paper, to illustrate dynamic characteristics of mechanical ventilated respiratory system with 2 different lungs, we propose a mathematical model of mechanical ventilated respiratory system with 2 different lungs and conduct experiments to verify the model. Furthermore, we study the dynamics of mechanical ventilated respiratory system with 2 different lungs. This research study can be used for improving the efficiency and safety of volume-controlled mechanical ventilation system.
authors.affiliation: School of Automation Science and Electrical Engineering, Beihang University, Beijing, China.|Beijing Engineering Research Center of Diagnosis and Treatment of Respiratory and Critical Care Medicine, Beijing Chaoyang Hospital, Beijing, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Shi
authors.affiliation: School of Automation Science and Electrical Engineering, Beihang University, Beijing, China.|Beijing Engineering Research Center of Diagnosis and Treatment of Respiratory and Critical Care Medicine, Beijing Chaoyang Hospital, Beijing, China.
authors.forename: Bolun
authors.initials: B
authors.lastname: Zhang
authors.affiliation: School of Automation Science and Electrical Engineering, Beihang University, Beijing, China.|Beijing Engineering Research Center of Diagnosis and Treatment of Respiratory and Critical Care Medicine, Beijing Chaoyang Hospital, Beijing, China.
authors.forename: Maolin
authors.initials: M
authors.lastname: Cai
authors.affiliation: Faculty of Health Sciences, University of Macau, Taipa, Macau.
authors.forename: Xiaohua Douglas
authors.initials: XD
authors.lastname: Zhang
mesh_terms: D006801:Humans; D007206:Individuality; D008168:Lung / Q000033:anatomy & histology / Q000502:physiology*; D008954:Models, Biological; D012121:Respiration, Artificial
keywords: double-lung model; dynamics; mechanical ventilation; respiratory system; simulation