title: Lymphoma Heterogeneity: Three Different Histological Pictures and One Unique Clone.
abstract: We report a patient who developed up to three different lymphomas with the same clonal IGH rearrangement. She was first diagnosed of splenic zone marginal lymphoma and relapsed for the first time with Hodgkin lymphoma histology and later with diffuse large B-cell lymphoma histology. Subsequent biopsies and analysis of clonally rearranged IGH genes helped to elucidate the clonal relationship between the three histologies and to confirm a common origin from the three tissue histologies. An integrated diagnosis should always be performed in order to achieve the most accurate diagnosis and be able to choose the best therapeutic options for our patients.
authors.affiliation: Hematology Department, University Hospital of Salamanca, Salamanca, Spain.
authors.forename: Sara
authors.initials: S
authors.lastname: Alonso-Alvarez
authors.affiliation: Hematology Department, University Hospital of Salamanca, Salamanca, Spain.
authors.forename: Alba
authors.identifier: 0000-0002-3678-2265
authors.initials: A
authors.lastname: Redondo-Guijo
authors.affiliation: Pathology Department, University Hospital of Salamanca, Salamanca, Spain.
authors.forename: Óscar
authors.initials: Ó
authors.lastname: Blanco
authors.affiliation: Hematology Department, University Hospital of Salamanca, Salamanca, Spain.
authors.forename: Miguel
authors.initials: M
authors.lastname: Alcoceba
authors.affiliation: Hematology Department, University Hospital of Salamanca, Salamanca, Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: Balanzategui
authors.affiliation: Hematology Department, University Hospital of Salamanca, Salamanca, Spain.
authors.forename: Juan C
authors.initials: JC
authors.lastname: Caballero
authors.affiliation: Hematology Department, University Hospital of Salamanca, Salamanca, Spain.
authors.forename: Julio
authors.initials: J
authors.lastname: Dávila
authors.affiliation: Hematology Department, University Hospital of Salamanca, Salamanca, Spain.
authors.forename: Marcos
authors.initials: M
authors.lastname: González
authors.affiliation: Hematology Department, University Hospital of Salamanca, Salamanca, Spain.
authors.forename: María D
authors.initials: MD
authors.lastname: Caballero
authors.affiliation: Hematology Department, University Hospital of Salamanca, Salamanca, Spain.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Martín
authors.affiliation: Hematology Department, University Hospital of Salamanca, Salamanca, Spain.
authors.forename: Ramón
authors.initials: R
authors.lastname: García-Sanz