title: Molecular Imaging and Precision Medicine in Dementia and Movement Disorders.
abstract: Precision medicine (PM) has been defined as "prevention and treatment strategies that take individual variability into account." Molecular imaging (MI) is an ideally suited tool for PM approaches to neurodegenerative dementia and movement disorders (MD). Here we review PM approaches and discuss how they may be applied to other associated neurodegenerative dementia and MD. With ongoing major therapeutic research initiatives that include the use of molecular imaging, we look forward to established interventions targeted to specific molecular pathophysiology and expect the potential benefit of MI PM approaches in neurodegenerative dementia and MD will only increase.
authors.affiliation: Department of Radiology and Imaging Sciences, School of Medicine, University of Utah, Room: 1A71, 30 North 1900 East, Salt Lake City, UT 84132, USA.
authors.forename: Atul K
authors.initials: AK
authors.lastname: Mallik
authors.affiliation: Department of Nuclear Medicine, University Hospital of Cologne, Kerpener Street 62, Cologne 50937, Germany.
authors.forename: Alexander
authors.initials: A
authors.lastname: Drzezga
authors.affiliation: Department of Radiology and Imaging Sciences, School of Medicine, University of Utah, Room: 1A71, 30 North 1900 East, Salt Lake City, UT 84132, USA. Electronic address: sminoshima@hsc.utah.edu.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Minoshima
mesh_terms: D014408:Biomarkers, Tumor; D003704:Dementia / Q000000981:diagnostic imaging* / Q000628:therapy*; D019788:Fluorodeoxyglucose F18; D006801:Humans; D057054:Molecular Imaging; D058990:Molecular Targeted Therapy; D009069:Movement Disorders / Q000000981:diagnostic imaging* / Q000628:therapy*; D049268:Positron-Emission Tomography; D057285:Precision Medicine; D011237:Predictive Value of Tests; D019275:Radiopharmaceuticals; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D014408:Biomarkers, Tumor; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
keywords: Alzheimer disease; Dementia; Molecular imaging; Movement disorder; PET; Parkinson disease; Precision medicine; SPECT