title: Cordyceps sinensis biomass produced by submerged fermentation in high-fat diet feed rats normalizes the blood lipid and the low testosterone induced by diet.
abstract: This study investigated the effect ofCordyceps sinensisbiomass supplementation obtained from submerged fermentation on blood lipid and low testosterone induced by high-fat diet (HFD). The experiments were carried out using a long-term intake of HFD and HFD plus Simvastatin orC. sinensis(4 months). Our results show that plasma cholesterol, triglycerides and LDL were decreased byCordyceps sinensisbiomass supplementation (CSBS). A long-term intake of HFD caused a significant liver damage which has been reverted by CSBS. CSBS normalized decreasing testosterone levels observed in high-fat diet feed rats. All these findings lead us to suggest thatC. sinensiswas able to decrease blood lipid concentration, increase hepatoprotective activity and normalize testosterone levels.
authors.affiliation: Federal University of Paraná, Department of Bioprocesses and Biotechnology - Usina piloto B, Curitiba - PR - Brazil.
authors.forename: Leandro
authors.initials: L
authors.lastname: Freire Dos Santos
authors.affiliation: UFPR Clinical hospital, Brazil.
authors.forename: Rosália
authors.initials: R
authors.lastname: Rubel
authors.affiliation: Pelé Pequeno Príncipe Institute, Brazil.
authors.forename: Sandro José Ribeiro
authors.initials: SJ
authors.lastname: Bonatto
authors.affiliation: Department of Physiology, Federal University of Paraná, Brazil.
authors.forename: Ana Lucia
authors.initials: AL
authors.lastname: Zanatta
authors.affiliation: Department of Physiology, Federal University of Paraná, Brazil.
authors.forename: Júlia
authors.initials: J
authors.lastname: Aikawa
authors.affiliation: Department of Physiology, Federal University of Paraná, Brazil.
authors.forename: Adriana Aya
authors.initials: AA
authors.lastname: Yamaguchi
authors.affiliation: Anatomy department, Federal University of Paraná, Brazil.
authors.forename: Maria Fernanda
authors.initials: MF
authors.lastname: Torres
authors.affiliation: Federal University of Paraná, Department of Bioprocesses and Biotechnology - Usina piloto B, Curitiba - PR - Brazil; Industrial Biotechnology graduate program, Positivo University, Brazil.
authors.forename: Vanete Thomaz
authors.initials: VT
authors.lastname: Soccol
authors.affiliation: Federal Technological University of Paraná - Military Institute of Engineering, Brazil.
authors.forename: Sascha
authors.initials: S
authors.lastname: Habu
authors.affiliation: Department of Pathology, Federal University of Paraná, Brazil.
authors.forename: Karin Braun
authors.initials: KB
authors.lastname: Prado
authors.affiliation: Federal University of Paraná, Department of Bioprocesses and Biotechnology - Usina piloto B, Curitiba - PR - Brazil.
authors.forename: Carlos Ricardo
authors.initials: CR
authors.lastname: Soccol
keywords: Cordyceps sinensis; high-fat diet; hypolipidemic effect; testosterone