title: CD98 signals controlling tumorigenesis.
abstract: CD98 is implicated in a large number of cancers. CD98 regulates amino acid transport and integrin signaling, which are key drivers in tumor progression. The light chain in the CD98 heterodimer functions as an amino acid exchanger. Alongside the light chain, the heavy chain forms a heterocomplex at the plasma membrane to mediate signaling pathways. In this article, we review various approaches to blocking CD98 activity, which may lead to novel opportunities in cancer therapeutics.
authors.affiliation: Guy's and St Thomas' NHS Foundation Trust, United Kingdom. Electronic address: hughip@gmail.com.
authors.forename: Hugh
authors.initials: H
authors.lastname: Ip
authors.affiliation: Respiratory Immunology Autoimmunity Translational Medicine Unit, Early Clinical Development, AstraZeneca, United Kingdom. Electronic address: Tariq.Sethi@astrazeneca.com.
authors.forename: Tariq
authors.initials: T
authors.lastname: Sethi
mesh_terms: D000818:Animals; D063646:Carcinogenesis; D027261:Fusion Regulatory Protein-1 / Q000378:metabolism*; D006801:Humans; D015398:Signal Transduction
chemical_list: D027261:Fusion Regulatory Protein-1
keywords: Amino acid transport; CD98;Cancer; Integrins; Signalling