title: Time-resolved fluorescence spectroscopy for clinical diagnosis of actinic cheilitis.
abstract: Actinic cheilitis is a potentially malignant disorder of the lips. Its first cause is believed to be UV sun radiation. The lesion is highly heterogeneous, making the choice of area to be biopsied difficult. This study exploits the capabilities of time-resolved fluorescence spectroscopy for the identification of the most representative area to be biopsied. A preliminary study was performed on fourteen patients. A classification algorithm was used on data acquired on nine different biopsies. The algorithm discriminated between absent, mild, and moderate dysplasia with a sensitivity of 92.9%, 90.0%, and 80.0%, respectively. The false positive rate for healthy tissue (specificity) was 88.8%.
authors.affiliation: Museo Storico della Fisica e Centro Studi e Ricerche Enrico Fermi, Piazza del Viminale 1, 00184 Rome, Italy; IFAC-CNR, Istituto di Fisica Applicata "Nello Carrara," Consiglio Nazionale delle Ricerche, Via Madonna del Piano 10, 50019 Sesto Fiorentino, Italy; São Carlos Institute of Physics, University of São Paulo, PO Box 369, 13560-970, São Carlos, SP Brazil; a.cosci@ifac.cnr.it.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Cosci
authors.affiliation: São Carlos Institute of Physics, University of São Paulo, PO Box 369, 13560-970, São Carlos, SP Brazil; marcelosaitonogueira@gmail.com.
authors.forename: Marcelo Saito
authors.initials: MS
authors.lastname: Nogueira
authors.affiliation: São Carlos Institute of Physics, University of São Paulo, PO Box 369, 13560-970, São Carlos, SP Brazil.
authors.forename: Sebastião
authors.initials: S
authors.lastname: Pratavieira
authors.affiliation: Faculdade de Odontologia de Nova Friburgo, Universidade Federal Fluminense, RJ, Brazil.
authors.forename: Ademar
authors.initials: A
authors.lastname: Takahama
authors.affiliation: Faculdade de Odontologia de Nova Friburgo, Universidade Federal Fluminense, RJ, Brazil.
authors.forename: Rebeca de Souza
authors.initials: RS
authors.lastname: Azevedo
authors.affiliation: São Carlos Institute of Physics, University of São Paulo, PO Box 369, 13560-970, São Carlos, SP Brazil.
authors.forename: Cristina
authors.initials: C
authors.lastname: Kurachi
keywords: (170.3650) Lifetime-based sensing; (170.3890) Medical optics instrumentation; (170.6510) Spectroscopy, tissue diagnostics; (170.6935) Tissue characterization; (300.6500) Spectroscopy, time-resolved