title: Evaluation of risk for metabolic syndrome according to the fasting insulin concentration in Korean men.
abstract: BACKGROUND
  As a well-known risk factor for cardiovascular disease, metabolic syndrome (MetS) is an important global health problem due to its high worldwide prevalence. The objective of this study is to determine whether the fasting serum insulin concentration influences future incidence of MetS.
  
  
  METHODS
  A total of 14,621 Korean men without MetS participating in a medical health check-up program were followed up from 2005 until 2010. They were divided into 4 groups according to baseline fasting insulin concentrations. The incidence of MetS was compared among the groups, and Cox proportional hazards model was used to determine if MetS was associated with higher fasting insulin concentration.
  
  
  RESULTS
  The incidence of MetS increased according to the baseline fasting insulin concentration (first quartile: 8.4%, second quartile: 12.3%, third quartile: 16.3%, fourth quartile: 26.5%, P<0.001). Even after adjusting for multiple covariates, the hazard ratio (95% CI) for MetS was higher for the second (1.13 (0.93-1.37)), third (1.29 (1.06-1.56)) and fourth quartile group (1.70 (1.36-2.13)), compared to the first quartile group (P for trend <0.001).
  
  
  CONCLUSIONS
  The incidence of MetS increased proportionally to fasting insulin concentration. Additionally, increased fasting insulin concentration was an independent risk factor for the future development of MetS.
authors.affiliation: Total healthcare center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
authors.forename: Ju Young
authors.initials: JY
authors.lastname: Jung
authors.affiliation: Center for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
authors.forename: Sung Keun
authors.initials: SK
authors.lastname: Park
authors.affiliation: Departments of Preventive Medicine, School of Medicine, Kyung Hee University, Seoul, Republic of Korea.
authors.forename: Joong-Myung
authors.initials: JM
authors.lastname: Choi
authors.affiliation: Department of Radiology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
authors.forename: Hyun Pyo
authors.initials: HP
authors.lastname: Hong
authors.affiliation: Department of Dermatologyz, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
authors.forename: Young-Jun
authors.initials: YJ
authors.lastname: Choi
authors.affiliation: Departments of Preventive Medicine, School of Medicine, Kyung Hee University, Seoul, Republic of Korea. Electronic address: armani131@naver.com.
authors.forename: Jae-Hong
authors.initials: JH
authors.lastname: Ryoo
mesh_terms: D000328:Adult; D005215:Fasting / Q000097:blood*; D006801:Humans; D007328:Insulin / Q000097:blood*; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000453:epidemiology*; D008875:Middle Aged; D056910:Republic of Korea / Q000453:epidemiology; D012306:Risk
chemical_list: D007328:Insulin
keywords: Hyperinsulinemia; Insulin; Metabolic syndrome