title: Bacterial lipoproteins; biogenesis, sorting and quality control.
abstract: Bacterial lipoproteins are a subset of membrane proteins localized on either leaflet of the lipid bilayer. These proteins are anchored to membranes through their N-terminal lipid moiety attached to a conserved Cys. Since the protein moiety of most lipoproteins is hydrophilic, they are expected to play various roles in a hydrophilic environment outside the cytoplasmic membrane. Gram-negative bacteria such as Escherichia coli possess an outer membrane, to which most lipoproteins are sorted. The Lol pathway plays a central role in the sorting of lipoproteins to the outer membrane after lipoprotein precursors are processed to mature forms in the cytoplasmic membrane. Most lipoproteins are anchored to the inner leaflet of the outer membrane with their protein moiety in the periplasm. However, recent studies indicated that some lipoproteins further undergo topology change in the outer membrane, and play critical roles in the biogenesis and quality control of the outer membrane. This article is part of a Special Issue entitled: Bacterial Lipids edited by Russell E. Bishop.
authors.affiliation: University of Morioka, Takizawa, Iwate 020-0694, Japan.
authors.forename: Shin-Ichiro
authors.initials: SI
authors.lastname: Narita
authors.affiliation: University of Morioka, Takizawa, Iwate 020-0694, Japan. Electronic address: htokuda@morioka-u.ac.jp.
authors.forename: Hajime
authors.initials: H
authors.lastname: Tokuda
mesh_terms: D001419:Bacteria / Q000378:metabolism*; D001425:Bacterial Outer Membrane Proteins / Q000096:biosynthesis* / Q000737:chemistry; D002462:Cell Membrane / Q000378:metabolism*; D057927:Hydrophobic and Hydrophilic Interactions; D008074:Lipoproteins / Q000096:biosynthesis* / Q000737:chemistry; D008958:Models, Molecular; D011487:Protein Conformation; D021381:Protein Transport; D013329:Structure-Activity Relationship
chemical_list: D001425:Bacterial Outer Membrane Proteins; D008074:Lipoproteins