title: Efficacy comparison of atorvastatin versus rosuvastatin on blood lipid and microinflammatory state in maintenance hemodialysis patients.
abstract: BACKGROUND
  To investigate the effect of Atorvastatin (ATO) and Rosuvastatin (ROS) on blood lipid, high sensitivity CRP (hs-CRP), interleukin-6 (IL-6), albumin (ALB), prealbumin (PA), and transferring (TF) in maintenance hemodialysis (MHD) patients.
  
  
  METHODS
  Eighty MHD patients were enrolled and divided into two groups: ROS and ATO. Patients in Group ROS (n = 38) received ROS (10 mg/day), and those in group ATO (n = 42) received ATO (20 mg/day) for 12 weeks, respectively.
  
  
  RESULTS
  Administration of ROS and ATO both significantly reduced the concentrations of TC, LDL-C, TG, hs-CRP, and IL-6, but increased high-density lipoproteincholesterol (HDL-C), ALB, PA, and TF levels. Furthermore, the level of LDL-C decreased more significantly with inhibited microinflammation and improved nutrition situation in ROS group compared with ATO group. ATO and ROS not only decreased blood lipid levels but also inhibited the microinflammatory state and improved nutrition situation in MHD patients.
  
  
  CONCLUSIONS
  The results have shown that ROS is better than ATO in the treatment of MHD patients.
authors.affiliation: a Division of Nephrology , Nanfang Hospital, Southern Medical University, National Clinical Research Center of Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Institute of Nephrology , Guangzhou , PR China.
authors.forename: Jianwei
authors.initials: J
authors.lastname: Tian
authors.affiliation: a Division of Nephrology , Nanfang Hospital, Southern Medical University, National Clinical Research Center of Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Institute of Nephrology , Guangzhou , PR China.|b Division of Nephrology , the First Affiliated Hospital of Inner Mongolia Medical University , Hohhot , PR China.
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Hou
authors.affiliation: a Division of Nephrology , Nanfang Hospital, Southern Medical University, National Clinical Research Center of Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Institute of Nephrology , Guangzhou , PR China.
authors.forename: Liping
authors.initials: L
authors.lastname: Hu
authors.affiliation: a Division of Nephrology , Nanfang Hospital, Southern Medical University, National Clinical Research Center of Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Institute of Nephrology , Guangzhou , PR China.
authors.forename: Ting
authors.initials: T
authors.lastname: Chen
authors.affiliation: c Department of Nephrology , the First Affiliated Hospital, Shantou Medical University , Shantou , PR China.
authors.forename: Kefei
authors.initials: K
authors.lastname: Wu
authors.affiliation: c Department of Nephrology , the First Affiliated Hospital, Shantou Medical University , Shantou , PR China.
authors.forename: Chudan
authors.initials: C
authors.lastname: Cai
authors.affiliation: a Division of Nephrology , Nanfang Hospital, Southern Medical University, National Clinical Research Center of Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Institute of Nephrology , Guangzhou , PR China.
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Bai
mesh_terms: D000328:Adult; D000069059:Atorvastatin / Q000008:administration & dosage*; D002097:C-Reactive Protein / Q000032:analysis; D002681:China; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage*; D015850:Interleukin-6 / Q000097:blood; D007676:Kidney Failure, Chronic / Q000628:therapy*; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D000068718:Rosuvastatin Calcium / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; C508600:IL6 protein, human; D015850:Interleukin-6; D008055:Lipids; D000068718:Rosuvastatin Calcium; D002097:C-Reactive Protein; D000069059:Atorvastatin
keywords: Atorvastatin; hemodialysis; lipid; malnutrition; microinflammatory; rosuvastatin