title: Exploring the anti-biofilm activity of cinnamic acid derivatives in Candida albicans.
abstract: Some compounds, characterized by phenylethenyl moiety, such as methyl cinnamate and caffeic acid phenethyl ester, are able to inhibit C. albicans biofilm formation. On these bases, and as a consequence of our previous work, we synthesized a series of cinnamoyl ester and amide derivatives in order to evaluate them for the activity against C. albicans biofilm and planktonically grown cells. The most active compounds 7 and 8 showed ⩾50% biofilm inhibition concentrations (BMIC50) of 2μg/mL and 4μg/mL respectively, against C. albicans biofilm formation; otherwise, 7 showed an interesting activity also against mature biofilm, with BMIC50of 8μg/mL.
authors.affiliation: Department of Chimica e Tecnologie del Farmaco, Sapienza University of Rome, P.le A. Moro, 5, I-00185 Rome, Italy.
authors.forename: Daniela
authors.initials: D
authors.lastname: De Vita
authors.affiliation: Department of Public Health and Infectious Diseases, "Sapienza" University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.
authors.forename: Giovanna
authors.initials: G
authors.lastname: Simonetti
authors.affiliation: Department of Chimica e Tecnologie del Farmaco, Sapienza University of Rome, P.le A. Moro, 5, I-00185 Rome, Italy.
authors.forename: Fabiana
authors.initials: F
authors.lastname: Pandolfi
authors.affiliation: Department of Chimica e Tecnologie del Farmaco, Sapienza University of Rome, P.le A. Moro, 5, I-00185 Rome, Italy; "Istituto Pasteur-Fondazione Cenci Bolognetti", Department of Chimica e Tecnologie del Farmaco, Sapienza University of Rome, P.le A. Moro, 5, I-00185 Rome, Italy.
authors.forename: Roberta
authors.initials: R
authors.lastname: Costi
authors.affiliation: Department of Chimica e Tecnologie del Farmaco, Sapienza University of Rome, P.le A. Moro, 5, I-00185 Rome, Italy; "Istituto Pasteur-Fondazione Cenci Bolognetti", Department of Chimica e Tecnologie del Farmaco, Sapienza University of Rome, P.le A. Moro, 5, I-00185 Rome, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Di Santo
authors.affiliation: Department of Public Health and Infectious Diseases, "Sapienza" University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.
authors.forename: Felicia Diodata
authors.initials: FD
authors.lastname: D'Auria
authors.affiliation: "Istituto Pasteur-Fondazione Cenci Bolognetti", Department of Chimica e Tecnologie del Farmaco, Sapienza University of Rome, P.le A. Moro, 5, I-00185 Rome, Italy. Electronic address: luigi.scipione@uniroma1.it.
authors.forename: Luigi
authors.initials: L
authors.lastname: Scipione
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D018441:Biofilms / Q000187:drug effects*; D002176:Candida albicans / Q000187:drug effects* / Q000378:metabolism; D002934:Cinnamates / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: D000935:Antifungal Agents; D002934:Cinnamates; C029010:cinnamic acid
keywords: Biofilm; Candida albicans; Cinnamic esters; Cinnamoyl amides