title: Fabrication and characterization of graphene-based hybrid nanocomposite: assessment of antibacterial potential and biomedical application.
abstract: The present investigation deals with synthesis of graphene oxide (GO) and fabrication of GO-based hybrid nanocomposites (Ncs). Synthesized GO and Ncs were primarily confirmed by UV visible and Fourier transform infrared (FT-IR) spectroscopy. Fabricated Ncs showed potential antimicrobial activity against Gram-positive and Gram-negative bacterial strains. Surface morphology, Elemental analysis, and FTIR imaging analysis were carried out to confirm Ncs formation. The Ncs were impregnated into the pullulan polymeric layer-by-layer (LbL) ultrathin film by using novel spin-coating approach. Mechanical properties were determined using Brookfield texture analyzer, and percentage moisture content confirmed the physicochemical stability of LbL film.
authors.affiliation: a Post Graduate Department of Pharmaceutics , H. R. Patel Institute of Pharmaceutical Education and Research , Shirpur , India.
authors.forename: Mahesh P
authors.initials: MP
authors.lastname: More
authors.affiliation: a Post Graduate Department of Pharmaceutics , H. R. Patel Institute of Pharmaceutical Education and Research , Shirpur , India.
authors.forename: Mahendra D
authors.initials: MD
authors.lastname: Patil
authors.affiliation: a Post Graduate Department of Pharmaceutics , H. R. Patel Institute of Pharmaceutical Education and Research , Shirpur , India.
authors.forename: Abhijeet P
authors.initials: AP
authors.lastname: Pandey
authors.affiliation: b Department of Pharmaceutical Chemistry , H. R. Patel Institute of Pharmaceutical Education and Research , Shirpur , India.
authors.forename: Pravin O
authors.initials: PO
authors.lastname: Patil
authors.affiliation: a Post Graduate Department of Pharmaceutics , H. R. Patel Institute of Pharmaceutical Education and Research , Shirpur , India.
authors.forename: Prashant K
authors.initials: PK
authors.lastname: Deshmukh
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology* / Q000633:toxicity; D048271:Chitosan / Q000737:chemistry; D006108:Graphite / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D053761:Nanocomposites / Q000737:chemistry* / Q000633:toxicity; D010087:Oxides / Q000737:chemistry; D010316:Particle Size; D013718:Tensile Strength; D014867:Water / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D010087:Oxides; D014867:Water; D006108:Graphite; D048271:Chitosan
keywords: Graphene; antimicrobial; hybrid nanocomposite; layer-by-layer film; spin coating