title: Access to a new class of synthetic building blocksviatrifluoromethoxylation of pyridines and pyrimidines.
abstract: Since the first synthesis of trifluoromethyl ethers in 1935, the trifluoromethoxy (OCF3) group has made a remarkable impact in medicinal, agrochemical, and materials science research. However, our inability to facilely incorporate the OCF3group into molecules, especially heteroaromatics, has limited its potential across a broad spectrum of technological applications. Herein, we report a scalable and operationally simple protocol for regioselective trifluoromethoxylation of a wide range of functionalized pyridines and pyrimidines under mild reaction conditions. The trifluoromethoxylated products are useful scaffolds that can be further elaborated by amidation and palladium-catalysed cross coupling reactions. Mechanistic studies suggest that a radicalO-trifluoromethylation followed by the OCF3-migration reaction pathway is operable. Given the unique properties of the OCF3group and the ubiquity of pyridine and pyrimidine in biologically active molecules and functional materials, trifluoromethoxylated pyridines and pyrimidines could serve as valuable building blocks for the discovery and development of new drugs, agrochemicals, and materials.
authors.affiliation: Department of Chemistry, Stony Brook University, Stony Brook, New York 11794-3400, USA; Institute of Chemical Biology and Drug Discovery, Stony Brook University, Stony Brook, New York 11794-3400, USA.
authors.forename: Pengju
authors.initials: P
authors.lastname: Feng
authors.affiliation: Department of Chemistry, Stony Brook University, Stony Brook, New York 11794-3400, USA; Institute of Chemical Biology and Drug Discovery, Stony Brook University, Stony Brook, New York 11794-3400, USA.
authors.forename: Katarzyna N
authors.initials: KN
authors.lastname: Lee
authors.affiliation: Department of Chemistry, Stony Brook University, Stony Brook, New York 11794-3400, USA; Institute of Chemical Biology and Drug Discovery, Stony Brook University, Stony Brook, New York 11794-3400, USA.
authors.forename: Johnny W
authors.initials: JW
authors.lastname: Lee
authors.affiliation: Department of Chemistry, Stony Brook University, Stony Brook, New York 11794-3400, USA; Institute of Chemical Biology and Drug Discovery, Stony Brook University, Stony Brook, New York 11794-3400, USA.
authors.forename: Chengbo
authors.initials: C
authors.lastname: Zhan
authors.affiliation: Department of Chemistry, Stony Brook University, Stony Brook, New York 11794-3400, USA; Institute of Chemical Biology and Drug Discovery, Stony Brook University, Stony Brook, New York 11794-3400, USA.
authors.forename: Ming-Yu
authors.initials: MY
authors.lastname: Ngai