title: Vancomycin-induced thrombocytopenia in a newborn.
abstract: Neonatal thrombocytopenia is common and is frequently seen in neonatal sepsis. Drug-induced thrombocytopenia is likely to be missed unless a high index of suspicion is present. Changing of antibiotics for assumed nonresolution of sepsis may lead to persistent thrombocytopenia in a neonate if drug-induced thrombocytopenia is missed. Vancomycin-induced neonatal thrombocytopenia is rarely described in scientific literature. We describe a newborn who was diagnosed with early onset sepsis and vancomycin-induced thrombocytopenia. Other causes of thrombocytopenia such as sepsis, alloimmune thrombocytopenia, thrombosis etc. were excluded. The platelet counts normalized within 72 h of stopping vancomycin. Vancomycin-induced IgM platelet antibodies could not be done in our case (due to financial constraints), but their absence does not exclude the diagnosis of vancomycin-induced thrombocytopenia.
authors.forename: Kunal
authors.initials: K
authors.lastname: Kalra
authors.forename: Hema Gupta
authors.initials: HG
authors.lastname: Mittal
authors.forename: Arti
authors.initials: A
authors.lastname: Maria
mesh_terms: D006801:Humans; D007231:Infant, Newborn; D008297:Male; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D014640:Vancomycin / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D014640:Vancomycin