title: Adenosine Producing Mesenchymal Stem Cells.
abstract: Recent findings support the importance of the adenosine pathway in human immunology. Tissue specific differences exist with respect to the capacity of mesenchymal stem cells (MSC) to produce immune regulatory ATP metabolites. While some MSC may produce adenosine in a cell-autonomous fashion, other types of MSC require the cooperative activity of T-cells. Stem Cells 2017;35:1647-1648.
authors.affiliation: Department of Oto-Rhino-Laryngology, Head and Neck Surgery, Ulm University Medical Center, Ulm, Germany.
authors.forename: Patrick J
authors.initials: PJ
authors.lastname: Schuler
authors.affiliation: Department of Oto-Rhino-Laryngology, Head and Neck Surgery, University of Duisburg-Essen, Essen, Germany.
authors.forename: Sven
authors.initials: S
authors.lastname: Brandau
mesh_terms: D000241:Adenosine / Q000096:biosynthesis*; D015703:Antigens, CD / Q000378:metabolism; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000378:metabolism*; D059016:Tumor Microenvironment
chemical_list: D015703:Antigens, CD; D000241:Adenosine
keywords: Adenosine; Head and neck cancer; Mesenchymal stem cells; Microenvironment; Treg; Tumor