title: Antioxidant and anti-hyperlipidemic effects of mycelia zinc polysaccharides by Pleurotus eryngii var. tuoliensis.
abstract: The aims of this work were designed to investigate the hepatoprotective and antioxidant effects of acidic- and alkali-extractable mycelia zinc polysaccharides (AcMZPS, AlMZPS) from Pleurotus eryngii var. tuoliensis on high-fat-high-cholesterol emulsion-induced hyperlipidemic mice. The in vivo experiments demonstrated that both AcMZPS and AlMZPS had potential hepatoprotective effects by significantly decreasing the levels of LDL-C, VLDL-C, TC, TG, ALT, AST, ALP, MDA and LPO, and remarkably increasing the HDL-C, SOD, GSH-Px, and CAT in serum lipid/liver homogenate, respectively. In addition, four polysaccharide fractions of AcMZPS-1, AcMZPS-2, AlMZPS-1, and AlMZPS-2, purified from AcMZPS and AlMZPS using DEAE chromatography, respectively, were subjected to monosaccharide composition analysis and valuated for the in vitro antioxidant activity. The results obtained in present study suggested that AcMZPS, AlMZPS and their purified fractions could be used as functional foods and natural drugs in preventing the hyperlipidemia and non-alcoholic fatty liver.
authors.affiliation: Institute of Plant and Environment Protection, Beijing Academy of Agriculture and Forestry Sciences, Beijing Engineering Research Center for Edible Mushroom, Key Laboratory of Urban Agriculture (North), Ministry of Agriculture, Beijing, PR China; College of Life Science, Shandong Agricultural University, Taian 271018, PR China.
authors.forename: Nuo
authors.initials: N
authors.lastname: Xu
authors.affiliation: College of Life Science, Shandong Agricultural University, Taian 271018, PR China.
authors.forename: Zhenzhen
authors.initials: Z
authors.lastname: Ren
authors.affiliation: College of Life Science, Shandong Agricultural University, Taian 271018, PR China.
authors.forename: Jianjun
authors.initials: J
authors.lastname: Zhang
authors.affiliation: College of Life Science, Shandong Agricultural University, Taian 271018, PR China.
authors.forename: Xinling
authors.initials: X
authors.lastname: Song
authors.affiliation: College of Life Science, Shandong Agricultural University, Taian 271018, PR China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Gao
authors.affiliation: College of Life Science, Shandong Agricultural University, Taian 271018, PR China.
authors.forename: Huijuan
authors.initials: H
authors.lastname: Jing
authors.affiliation: College of Life Science, Shandong Agricultural University, Taian 271018, PR China.
authors.forename: Shangshang
authors.initials: S
authors.lastname: Li
authors.affiliation: Institute of Plant and Environment Protection, Beijing Academy of Agriculture and Forestry Sciences, Beijing Engineering Research Center for Edible Mushroom, Key Laboratory of Urban Agriculture (North), Ministry of Agriculture, Beijing, PR China. Electronic address: wangshouxian2002@163.com.
authors.forename: Shouxian
authors.initials: S
authors.lastname: Wang
authors.affiliation: College of Life Science, Shandong Agricultural University, Taian 271018, PR China. Electronic address: jiale0525@163.com.
authors.forename: Le
authors.initials: L
authors.lastname: Jia
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D001835:Body Weight / Q000187:drug effects; D019610:Cytoprotection / Q000187:drug effects; D062610:Fungal Polysaccharides / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D006863:Hydrogen-Ion Concentration; D000960:Hypolipidemic Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D008099:Liver / Q000187:drug effects / Q000473:pathology; D051379:Mice; D009005:Monosaccharides / Q000032:analysis; D025282:Mycelium / Q000737:chemistry*; D020076:Pleurotus / Q000737:chemistry*; D015032:Zinc / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D062610:Fungal Polysaccharides; D000960:Hypolipidemic Agents; D009005:Monosaccharides; D015032:Zinc
keywords: Antihyperlipidemic effects; Antioxidant effects; Pleurotus eryngii var. tuoliensis; Zinc polysaccharides