title: Splenic Metastasis from Cancer of Uterine Cervix-a Rare Case.
abstract: Cancer of uterine cervix is one of the most common malignancies in women. Metastatic recurrence of cervical cancer in spleen is rare, mostly seen in autopsies. Splenic metastasis from cervical cancer in a living patient without disseminated metastases is rarer. Here, we present the case of a lady aged 46 years with cervical cancer-squamous cell carcinoma-who had undergone radical hysterectomy and postoperative 50 Gy of intensity modulated radiation therapy in 25 fractions and 50 mg of weekly cisplatin for 6 weeks. She was doing well for 17 months. Then, she developed fever and anorexia, and was detected to have splenic lesion and a lesion in the pelvic mesentery in PET/CT (positron emission tomography-computed tomography). Laparoscopy showed enlarged spleen with a mass lesion and a mass in ileal mesentery adherent to the peritoneum over the fundus of bladder and greater omentum. She underwent resection of a segment of ileum with the mesenteric lesion and omentum and bladder peritoneum laparoscopically and splenectomy. Histopathological examination revealed both the mesenteric and splenic lesions to be metastases from poorly differentiated carcinoma, which was from the cervical cancer. Immunohistochemistry was suggestive of squamous cell carcinoma associated with high-risk human papilloma virus. After the postoperative recovery, patient was started on ciplatin with paclitaxel chemotherapy.
authors.affiliation: Dept of Surgical Oncology, Tower 3, HealthCare Global Hospital, No.8, Kalinga Rao Road, Sampangi Ram Nagar, Bengaluru, 560020 India.
authors.forename: Jagannath
authors.initials: J
authors.lastname: Dixit
authors.affiliation: Dept of Surgical Oncology, Tower 3, HealthCare Global Hospital, No.8, Kalinga Rao Road, Sampangi Ram Nagar, Bengaluru, 560020 India.
authors.forename: Noor
authors.initials: N
authors.lastname: Mohammed
authors.affiliation: Dept of Surgical Oncology, Tower 3, HealthCare Global Hospital, No.8, Kalinga Rao Road, Sampangi Ram Nagar, Bengaluru, 560020 India.
authors.forename: Preethi
authors.initials: P
authors.lastname: Shetty
keywords: Cancer of uterine cervix; Distant recurrence; Isolated metastases; Splenic metastsis; Squamous cell carcinoma