title: Antibiotics in malaria therapy: which antibiotics except tetracyclines and macrolides may be used against malaria?
abstract: Malaria, a parasite vector-borne disease, is one of the most significant health threats in tropical regions, despite the availability of individual chemoprophylaxis. Malaria chemoprophylaxis and chemotherapy remain a major area of research, and new drug molecules are constantly being developed before drug-resistant parasites strains emerge. The use of anti-malarial drugs is challenged by contra-indications, the level of resistance of Plasmodium falciparum in endemic areas, clinical tolerance and financial cost. New therapeutic approaches are currently needed to fight against this disease. Some antibiotics that have shown potential effects on malaria parasite have been recently studied in vitro or in vivo intensively. Two families, tetracyclines and macrolides and their derivatives have been particularly studied in recent years. However, other less well-known have been tested or are being used for malaria treatment. Some of these belong to older families, such as quinolones, co-trimoxazole or fusidic acid, while others are new drug molecules such as tigecycline. These emerging antibiotics could be used to prevent malaria in the future. In this review, the authors overview the use of antibiotics for malaria treatment.
authors.affiliation: Fédération des Laboratoires, Hôpital d'Instruction des Armées Saint Anne, Toulon, France.|Unité de Parasitologie et d'Entomologie, Département des Maladies Infectieuses, Institut de Recherche Biomédicale des Armées, Marseille, France.|Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, Aix Marseille Université, UM 63, CNRS 7278, IRD 198, Inserm 1095, Marseille, France.
authors.forename: Tiphaine
authors.initials: T
authors.lastname: Gaillard
authors.affiliation: Unité de Parasitologie et d'Entomologie, Département des Maladies Infectieuses, Institut de Recherche Biomédicale des Armées, Marseille, France.|Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, Aix Marseille Université, UM 63, CNRS 7278, IRD 198, Inserm 1095, Marseille, France.|Centre National de Référence du Paludisme, Marseille, France.
authors.forename: Marylin
authors.initials: M
authors.lastname: Madamet
authors.affiliation: Unité de Parasitologie et d'Entomologie, Département des Maladies Infectieuses, Institut de Recherche Biomédicale des Armées, Marseille, France.|Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, Aix Marseille Université, UM 63, CNRS 7278, IRD 198, Inserm 1095, Marseille, France.
authors.forename: Francis Foguim
authors.initials: FF
authors.lastname: Tsombeng
authors.affiliation: Unité de Parasitologie et d'Entomologie, Département des Maladies Infectieuses, Institut de Recherche Biomédicale des Armées, Marseille, France.|Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, Aix Marseille Université, UM 63, CNRS 7278, IRD 198, Inserm 1095, Marseille, France.
authors.forename: Jérôme
authors.initials: J
authors.lastname: Dormoi
authors.affiliation: Unité de Parasitologie et d'Entomologie, Département des Maladies Infectieuses, Institut de Recherche Biomédicale des Armées, Marseille, France. bruno.pradines@gmail.com.|Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, Aix Marseille Université, UM 63, CNRS 7278, IRD 198, Inserm 1095, Marseille, France. bruno.pradines@gmail.com.|Centre National de Référence du Paludisme, Marseille, France. bruno.pradines@gmail.com.
authors.forename: Bruno
authors.initials: B
authors.lastname: Pradines
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D000962:Antimalarials / Q000494:pharmacology* / Q000627:therapeutic use*; D058492:Drug Repositioning; D006801:Humans; D018942:Macrolides / Q000494:pharmacology / Q000627:therapeutic use; D016778:Malaria, Falciparum / Q000188:drug therapy*; D010963:Plasmodium falciparum / Q000187:drug effects*; D013754:Tetracyclines / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D000962:Antimalarials; D018942:Macrolides; D013754:Tetracyclines
keywords: Anti-malarial drug; Antibiotics; Malaria; Plasmodium falciparum; Prophylaxis; Resistance; Treatment