title: Systematic review and meta-analysis of prostatic artery embolisation for lower urinary tract symptoms related to benign prostatic hyperplasia.
abstract: OBJECTIVE
  To evaluate the efficacy of prostatic artery embolisation (PAE) in lower urinary tract symptoms (LUTS) related to benign prostatic hyperplasia (BPH) at short- and mid-term follow-up.
  
  
  METHODS
  The current study included 484 BPH patients from seven eligible studies. A meta-analysis was performed to determine the mean differences in parameters associated with LUTS, including the international prostate symptom score (IPSS), peak urinary flow (Qmax), post-void residual volume (PVR), quality of life score (QoL), prostate-specific antigen level (PSA), and prostatic volume (PV), between baseline and follow-up periods.
  
  
  RESULTS
  Nearly all parameters at follow-up of 3-24 months were significantly improved compared to the baseline. Mean differences in IPSS at 3, 6, 12, and 24 months were -14.06 (95% confidence interval [CI]: -16.47 to -11.64), -12.32 (95% CI: -15.57 to -9.08), -16.41 (95% CI: -19.81 to -13.02), and -17 (95% CI: -17.91 to -16.09), respectively. In addition, mean differences of Qmax, PVR, PV, and QoL between the follow-up period and baseline were improved significantly; however, there were no significant differences in PSA at 24 months.
  
  
  CONCLUSIONS
  The present data shows that PAE could improve LUTS by BPH after short- and mid-term follow-up; however, more cumulative studies for long-term follow-up and comparison with other therapeutic modalities will be needed.
authors.affiliation: Department of Pathology, Eulji University Hospital, Eulji University College of Medicine, Daejeon, Republic of Korea.
authors.forename: J-S
authors.initials: JS
authors.lastname: Pyo
authors.affiliation: Department of Urology, Chosun University Hospital, Chosun University School of Medicine, Gwangju, Republic of Korea. Electronic address: uro2097@gmail.com.
authors.forename: W J
authors.initials: WJ
authors.lastname: Cho
mesh_terms: D000368:Aged; D015984:Causality; D015897:Comorbidity; D004621:Embolization, Therapeutic / Q000706:statistics & numerical data*; D005500:Follow-Up Studies; D006801:Humans; D008137:Longitudinal Studies; D059411:Lower Urinary Tract Symptoms / Q000453:epidemiology* / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D011467:Prostate / Q000098:blood supply; D011470:Prostatic Hyperplasia / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000628:therapy*; D012307:Risk Factors; D016896:Treatment Outcome