title: Association of serum bactericidal antibody and opsonic antibody levels after Neisseria meningitidis serogroup C conjugate vaccine in Brazilian children and adolescents infected or not infected with HIV.
abstract: Neisseria meningitidis serogroup C (MenC) is the main causative agent of meningitis in Brazil. HIV infection affects the quality of the immune system. HIV+children have an increased risk of infection to encapsulated bacteria such as N. meningitidis. We evaluated the opsonic antibody (OPA) levels and its correlation with serum bactericidal antibody (SBA) levels induced by one and two doses of a MenC conjugate vaccine in children and adolescents HIV+and HIV-exposed but uninfected children (HEU) group. Overall the data show the importance of two doses of vaccine for HIV+individuals. About 79% and 58% of HIV+patients showed SBA and OPA positive response after two doses of vaccine, respectively. For HEU group, 62% and 41% of patients showed SBA and OPA positive response after one dose of vaccine, respectively. A positive and significant association between SBA and OPA levels was seen after two doses of vaccine in HIV+patients.
authors.affiliation: State University of Rio de Janeiro, Department of Microbiology, Immunology and Parasitology, Rio de Janeiro, Brazil. Electronic address: ferrazwp@yahoo.com.br.
authors.forename: Wânia F
authors.initials: WF
authors.lastname: Pereira-Manfro
authors.affiliation: State University of Rio de Janeiro, Department of Microbiology, Immunology and Parasitology, Rio de Janeiro, Brazil.
authors.forename: Raquel M
authors.initials: RM
authors.lastname: Alvino
authors.affiliation: State University of Rio de Janeiro, Department of Microbiology, Immunology and Parasitology, Rio de Janeiro, Brazil.
authors.forename: Aline C
authors.initials: AC
authors.lastname: Cruz
authors.affiliation: State University of Rio de Janeiro, Department of Microbiology, Immunology and Parasitology, Rio de Janeiro, Brazil.
authors.forename: Giselle P
authors.initials: GP
authors.lastname: Silva
authors.affiliation: State University of Rio de Janeiro, Department of Microbiology, Immunology and Parasitology, Rio de Janeiro, Brazil.
authors.forename: Raquel B N
authors.initials: RB
authors.lastname: Castro
authors.affiliation: Instituto de Puericultura e Pediatria Martagão Gesteira, School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
authors.forename: Bianca
authors.initials: B
authors.lastname: Ferreira
authors.affiliation: Instituto de Puericultura e Pediatria Martagão Gesteira, School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
authors.forename: Daniella M
authors.initials: DM
authors.lastname: Barreto
authors.affiliation: Instituto de Puericultura e Pediatria Martagão Gesteira, School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
authors.forename: Ana Cristina C
authors.initials: AC
authors.lastname: Frota
authors.affiliation: Instituto de Puericultura e Pediatria Martagão Gesteira, School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil; Preventive Medicine Department, School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
authors.forename: Cristina B
authors.initials: CB
authors.lastname: Hofer
authors.affiliation: State University of Rio de Janeiro, Department of Microbiology, Immunology and Parasitology, Rio de Janeiro, Brazil.
authors.forename: Lucimar G
authors.initials: LG
authors.lastname: Milagres
mesh_terms: D000293:Adolescent; D000907:Antibodies, Bacterial / Q000097:blood*; D001770:Blood Bactericidal Activity; D001938:Brazil; D002648:Child; D002675:Child, Preschool; D005260:Female; D015658:HIV Infections / Q000150:complications; D006801:Humans; D008297:Male; D008589:Meningococcal Infections / Q000517:prevention & control*; D022401:Meningococcal Vaccines / Q000008:administration & dosage / Q000276:immunology*; D038542:Neisseria meningitidis, Serogroup C / Q000276:immunology*; D009895:Opsonin Proteins / Q000097:blood*; D011446:Prospective Studies; D018074:Vaccines, Conjugate / Q000008:administration & dosage / Q000276:immunology
chemical_list: D000907:Antibodies, Bacterial; D022401:Meningococcal Vaccines; D009895:Opsonin Proteins; D018074:Vaccines, Conjugate
keywords: Bactericidal antibodies; HIV; Meningococcal conjugate vaccine; Neisseria meningitidis C; Opsonic antibodies