title: Trends in medication use in patients with type 2 diabetes mellitus: a long-term view of real-world treatment between 2000 and 2015.
abstract: BACKGROUND
  Despite the availability of a variety of treatments, many patients with type 2 diabetes mellitus (T2DM) are not achieving glucose control. We analyzed successive waves of the Adelphi Real World Diabetes Disease Specific Programmes (DSPs) to assess treatment patterns reported by primary care physicians (PCPs) and specialists and the effect of treatment on levels of glucose control.
  
  
  METHODS
  Data were collected between 2000 and 2015 in the US and EU5 (France, Germany, Italy, Spain, and the UK). Physicians completed patient record forms for the next 10 patients consulting with T2DM. Key aspects captured were change over time in therapy usage, time to insulin introduction, and glycated hemoglobin (HbA1c) levels.
  
  
  RESULTS
  Over 12 DSP waves, 3,555 specialists and 5,109 PCPs completed questionnaires for 70,657 patients. Treatment patterns changed considerably over time as new agents were introduced. The number of agents prescribed per patient increased over time, as did HbA1clevels at which physicians stated they would introduce insulin. The greatest improvements in HbA1clevels occurred during 2000-2008, with little improvement since 2008.
  
  
  CONCLUSIONS
  In this real-world setting, the proportion of patients with T2DM achieving good glucose control has not increased greatly since 2008. A better understanding of how to individualize treatment pathways may be required to improve control in these patients.
authors.affiliation: Adelphi Real World, Macclesfield, UK.
authors.forename: Victoria
authors.initials: V
authors.lastname: Higgins
authors.affiliation: Adelphi Real World, Macclesfield, UK.
authors.forename: James
authors.initials: J
authors.lastname: Piercy
authors.affiliation: Adelphi Real World, Macclesfield, UK.
authors.forename: Adam
authors.initials: A
authors.lastname: Roughley
authors.affiliation: Adelphi Real World, Macclesfield, UK.
authors.forename: Gary
authors.initials: G
authors.lastname: Milligan
authors.affiliation: Adelphi Real World, Macclesfield, UK.
authors.forename: Andrea
authors.initials: A
authors.lastname: Leith
authors.affiliation: Adelphi Real World, Macclesfield, UK.
authors.forename: James
authors.initials: J
authors.lastname: Siddall
authors.affiliation: Adelphi Real World, Macclesfield, UK.
authors.forename: Mike
authors.initials: M
authors.lastname: Benford
keywords: insulinization; real world; treatment trends; type 2 diabetes