title: Magnesium deficiency and oxidative stress: an update.
abstract: Magnesium deficiency (MgD) has been shown to impact numerous biological processes at the cellular and molecular levels. In the present review, we discuss the relationship between MgD and oxidative stress (OS). MgD is accompanied by increased levels of OS markers such as lipid, protein and DNA oxidative modification products. Additionally, a relationship was detected between MgD and a weakened antioxidant defence. Different mechanisms associated with MgD are involved in the development and maintenance of OS. These mechanisms include systemic reactions such as inflammation and endothelial dysfunction, as well as changes at the cellular level, such as mitochondrial dysfunction and excessive fatty acid production.
authors.affiliation: Department of Pharmacology, Volgograd State Medical University, Pl. Pavshikh Bortsov, 1, Volgograd, 400131, Russia.|Department of Immunology and Allergology, Volgograd State Medical University, Pl. Pavshikh Bortsov, 1, Volgograd, 400131, Russia.
authors.forename: Anastasia A
authors.initials: AA
authors.lastname: Zheltova
authors.affiliation: Department of Pharmacology, Volgograd State Medical University, Pl. Pavshikh Bortsov, 1, Volgograd, 400131, Russia.|Institute of Pharmacy, Department of Pharmacology and Toxicology, University of Innsbruck, Center for Chemistry and Biomedicine, Innrain 80-82/III, A-6020, Innsbruck, Austria.
authors.forename: Maria V
authors.initials: MV
authors.lastname: Kharitonova
authors.affiliation: Department of Pharmacology, Volgograd State Medical University, Pl. Pavshikh Bortsov, 1, Volgograd, 400131, Russia. iezhitsa@salam.uitm.edu.my.|Centre for Neuroscience Research (NeuRon), Faculty of Medicine, Universiti Teknologi MARA (UiTM), Sungai Buloh Campus, Jalan Hospital, 47000, Sungai Buloh, Selangor Darul Ehsan, Malaysia. iezhitsa@salam.uitm.edu.my.|RIG "Molecular Pharmacology and Advanced Therapeutics", Pharmaceutical & Life Sciences (PLS) Communities of Research (CoRe),, Universiti Teknologi MARA, 40450, Shah Alam, Selangor Darul Ehsan, Malaysia. iezhitsa@salam.uitm.edu.my.|Faculty of Medicine, Sungai Buloh Campus, Jalan Hospital, Universiti Teknologi MARA, 47000, Sungai Buloh, Selangor Darul Ehsan, Malaysia. iezhitsa@salam.uitm.edu.my.
authors.forename: Igor N
authors.initials: IN
authors.lastname: Iezhitsa
authors.affiliation: Department of Pharmacology, Volgograd State Medical University, Pl. Pavshikh Bortsov, 1, Volgograd, 400131, Russia.
authors.forename: Alexander A
authors.initials: AA
authors.lastname: Spasov
keywords: Antioxidants; Lipid peroxidation; Magnesium; Magnesium deficiency; Oxidative stress; Reactive oxygen species