title: [Presence of lactoferrin (LF) in lymphocutaneous sporotrichosis. Yeast-bound antimicrobial peptide].
abstract: Sporotrichosis is a common subcutaneous mycosis in Latin America, produced by dimorphic fungi belong to Sporothrix schenckii complex of cryptic species. Infection is acquired by traumatic inoculation with contaminated organic material. Host immune response includes polymorphonuclear neutrophils chemotaxis and release of granular components. Lactoferrin is a protein member of the transferrin family of iron-binding proteins, present inside polymorphonuclear granular structure, and has been reported to affect growth and development of infectious agents, including fungal organisms. Nevertheless, lactoferrin expression in sporotrichosis infections has not been reported yet.
  
  
  OBJECTIVE
  To determine the expression of lactoferrin using immunohistochemical staining in sporotrichosis human infection.
  
  
  METHODS
  The dermatology department's files during a period of five years were reviewed; cases with a diagnosis of sporotrichosis were selected and lactoferrin immunostaining was performed when enough biological material was available.
  
  
  RESULTS
  Three cases with a diagnosis of sporotrichosis and adequate biological material on paraffin block were identified. In all cases, lactoferrin immunostaining was positive around yeast cell.
authors.affiliation: Laboratorio de Inmunopotenciadores, Departamento de Sistemas Biológicos, Universidad Autónoma Metropolitana, Unidad Xochimilco, Ciudad de México, México.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Palma-Ramos
authors.affiliation: Laboratorio de Inmunopotenciadores, Departamento de Sistemas Biológicos, Universidad Autónoma Metropolitana, Unidad Xochimilco, Ciudad de México, México.
authors.forename: Laura E
authors.initials: LE
authors.lastname: Castrillón-Rivera
authors.affiliation: Subdirección de Investigación, Hospital General Dr. Manuel Gea González, Ciudad de México, México.
authors.forename: María Elisa
authors.initials: ME
authors.lastname: Vega-Mémije
authors.affiliation: Servicio de Micología, Hospital General Dr. Manuel Gea González, Ciudad de México, México.
authors.forename: Roberto
authors.initials: R
authors.lastname: Arenas-Guzmán
authors.affiliation: Departamento de Ecología de Agentes Patógenos, Hospital General Dr. Manuel Gea González, Ciudad de México, México.
authors.forename: Lucía
authors.initials: L
authors.lastname: Rangel-Gamboa
mesh_terms: D015496:CD4-Positive T-Lymphocytes; D006801:Humans; D007111:Immunity, Cellular; D007781:Lactoferrin / Q000032:analysis / Q000378:metabolism*; D008206:Lymphatic Diseases / Q000276:immunology / Q000378:metabolism* / Q000382:microbiology; D013175:Sporothrix; D013174:Sporotrichosis / Q000276:immunology / Q000378:metabolism* / Q000635:transmission
chemical_list: D007781:Lactoferrin