title: The effect ofQuercus brantiigall extract on burn wound healing in rat.
abstract: OBJECTIVE
  The aim of the present study was to evaluate the effect ofQuercus brantiigalls extract on the rat skin burn wound healing.
  
  
  METHODS
  Ethanol extract of the galls ofQ. brantiiwas used to treat the induced burn wounds on the back of 32 Wistar rats divided into 4 groups. The groups were treated by placebo, 1%, 2% and 4% concentration gall extract gels for 14 days and the efficacy of treatment was assessed based on reduction of burn wound area, as well as histological and molecular characteristics.
  
  
  RESULTS
  The mean wound surface in the 14thday, in all groups treated byQ. brantiigall extracts were larger than control group and the differences were statistically significant (P=0.043). The mean histological wound healing scores were not statistically different. Analysis of nitric oxide and platelet derived growth factor concentration in wound fluids in the 5thday of study showed that there was not any significant difference between groups (P=0.468 and 0.312 respectively). Fibroblast growth factor (bFGF) concentration in the wound fluids, was significantly higher in group treated with 1% gall extract gel in comparison to the control group (P=0.026).
  
  
  CONCLUSIONS
  Our results could not prove the significant positive effect ofQ. brantiigalls extract on the burning wound healing. More studies with more groups treated with different doses of theQ. brantiiextract are recommended.
authors.affiliation: Medical Students' Research Center, Isfahan University of Medical Sciences, Isfahan, Iran; Physiology Research Center, Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Faraidoon
authors.initials: F
authors.lastname: Haghdoost
authors.affiliation: Medical Students' Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Mohammad Mehdi
authors.initials: MM
authors.lastname: Baradaran Mahdavi
authors.affiliation: Department of Pharmacognosy and Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy, Isfahan University of Medical Sciences, HezarJarib Ave, Isfahan, Iran.
authors.forename: Behzad
authors.initials: B
authors.lastname: Zolfaghari
authors.affiliation: Department of Pathology, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Mohammad Hossein
authors.initials: MH
authors.lastname: Sanei
authors.affiliation: Physiology Research Center, Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Somaye
authors.initials: S
authors.lastname: Najafi
authors.affiliation: Medical Students' Research Center, Isfahan University of Medical Sciences, Isfahan, Iran; Physiology Research Center, Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Alireza
authors.initials: A
authors.lastname: Zandifar
authors.affiliation: Medical Students' Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Navid
authors.initials: N
authors.lastname: Manouchehri
authors.affiliation: Physiology Research Center, Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Shaghayegh Haghjooy
authors.initials: SH
authors.lastname: Javanmard
keywords: Burn wound healing; Gall extract; Quercus Brantii