title: Prospective non-randomized study on the use of antibiotic prophylaxis with ciprofloxacin in flexible urethrocystoscopy.
abstract: OBJECTIVE
  The goal of this study is to analyze whether there is a need for antibiotic prophylaxis in this outpatient procedure.
  
  
  METHODS
  Prospective observational non-randomized study including 100 patients divided into two groups: - Group 1: 48 patients receiving 500 mg of ciprofloxacin prophylaxis 1 hour before urethrocystoscopy; - Group 2: 52 patients without antibiotic prophylaxis. Before inclusion of the patients in the study, we checked the absence of urinary tract infection by means of a urinalysis obtained 3 days before the procedure. We analyze: cystoscopy indication, cystoscopy results, presence of comorbidities, urinalysis 7 days after the procedure, and urinary symptoms within 7 days of the procedure. The statistical analysis was performed using SPSS 20.0 and the statistical significance was p=0.05.
  
  
  RESULTS
  The average age of patients in group 1 was 66.7±12.4 versus 65.6±10.8 years in group 2 (p=0.6). There are no differences in the percentage of men/women included in the groups. 14% of patients of group 1 and 12% of group 2 presented bacteriuria, without showing any significant differences. In the multivariate study, it is observed that neither age, nor diabetes, smoking, lower urinary tract symptoms, nor immunosuppression are related with the onset of bacteriuria in the groups.
  
  
  CONCLUSIONS
  We do not consider the use of ciprofloxacin as prophylaxis for flexible cystoscopy is appropriate in this area of health, since it does not reduce the presence of urinary infection or bacteriuria.
authors.affiliation: UGC Urología intercentros. Hospital La Inmaculada. Huércal-Overa. Almería. España.
authors.forename: María Carmen
authors.initials: MC
authors.lastname: Cano-García
authors.affiliation: UGC Urología intercentros. Hospital La Inmaculada. Huércal-Overa. Almería. España.
authors.forename: Rosario
authors.initials: R
authors.lastname: Casares-Pérez
authors.affiliation: Instituto IBS Granada. Granada. España.
authors.forename: Miguel
authors.initials: M
authors.lastname: Arrabal-Martín
authors.affiliation: Servicio de Urología. Hospital de Poniente. El Ejido. Almería. España.
authors.forename: Sergio
authors.initials: S
authors.lastname: Merino-Salas
authors.affiliation: Instituto IBS Granada. Granada. España.
authors.forename: Miguel Ángel
authors.initials: MÁ
authors.lastname: Arrabal-Polo
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D019072:Antibiotic Prophylaxis; D002939:Ciprofloxacin / Q000627:therapeutic use*; D020684:Cystoscopes; D003558:Cystoscopy; D004867:Equipment Design; D005260:Female; D006801:Humans; D008297:Male; D011446:Prospective Studies; D014552:Urinary Tract Infections / Q000517:prevention & control*
chemical_list: D000900:Anti-Bacterial Agents; D002939:Ciprofloxacin