title: Insulin Clearance Is Associated with Hepatic Lipase Activity and Lipid and Adiposity Traits in Mexican Americans.
abstract: Reduction in insulin clearance plays an important role in the compensatory response to insulin resistance. Given the importance of this trait to the pathogenesis of diabetes, a deeper understanding of its regulation is warranted. Our goal was to identify metabolic and cardiovascular traits that are independently associated with metabolic clearance rate of insulin (MCRI). We conducted a cross-sectional analysis of metabolic and cardiovascular traits in 765 participants from the Mexican-American Coronary Artery Disease (MACAD) project who had undergone blood sampling, oral glucose tolerance test, euglycemic-hyperinsulinemic clamp, dual-energy X-ray absorptiometry, and carotid ultrasound. We assessed correlations of MCRI with traits from seven domains, including anthropometry, biomarkers, cardiovascular, glucose homeostasis, lipase activity, lipid profile, and liver function tests. We found inverse independent correlations between MCRI and hepatic lipase (P = 0.0004), insulin secretion (P = 0.0002), alanine aminotransferase (P = 0.0045), total fat mass (P = 0.014), and diabetes (P = 0.03). MCRI and apolipoprotein A-I exhibited a positive independent correlation (P = 0.035). These results generate a hypothesis that lipid and adiposity associated traits related to liver function may play a role in insulin clearance.
authors.affiliation: Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, United States of America.
authors.forename: Artak
authors.initials: A
authors.lastname: Labadzhyan
authors.affiliation: Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, United States of America.
authors.forename: Jinrui
authors.initials: J
authors.lastname: Cui
authors.affiliation: Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, United States of America.
authors.forename: Miklós
authors.initials: M
authors.lastname: Péterfy
authors.affiliation: Institute for Translational Genomics and Population Sciences, Los Angeles BioMedical Research Institute, Harbor-UCLA Medical Center, Torrance, California, United States of America.
authors.forename: Xiuqing
authors.initials: X
authors.lastname: Guo
authors.affiliation: Institute for Translational Genomics and Population Sciences, Los Angeles BioMedical Research Institute, Harbor-UCLA Medical Center, Torrance, California, United States of America.
authors.forename: Yii-Der I
authors.initials: YI
authors.lastname: Chen
authors.affiliation: Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, The Ohio State University, Columbus, Ohio, United States of America.
authors.forename: Willa A
authors.initials: WA
authors.lastname: Hsueh
authors.affiliation: Institute for Translational Genomics and Population Sciences, Los Angeles BioMedical Research Institute, Harbor-UCLA Medical Center, Torrance, California, United States of America.
authors.forename: Jerome I
authors.initials: JI
authors.lastname: Rotter
authors.affiliation: Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, United States of America.
authors.forename: Mark O
authors.initials: MO
authors.lastname: Goodarzi
mesh_terms: D015502:Absorptiometry, Photon; D050154:Adiposity / Q000235:genetics / Q000502:physiology; D000328:Adult; D016632:Apolipoprotein A-I / Q000097:blood*; D003430:Cross-Sectional Studies; D003920:Diabetes Mellitus / Q000097:blood* / Q000201:enzymology / Q000473:pathology; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood* / Q000235:genetics; D007333:Insulin Resistance / Q000235:genetics; D008049:Lipase / Q000097:blood* / Q000235:genetics; D008055:Lipids / Q000097:blood; D008099:Liver / Q000201:enzymology; D008297:Male; D017058:Mexican Americans / Q000235:genetics; D009765:Obesity / Q000097:blood* / Q000503:physiopathology
chemical_list: D016632:Apolipoprotein A-I; D007328:Insulin; C504173:LIPC protein, human; D008055:Lipids; D008049:Lipase