title: A Fresh Look at 'Aging' Proteins.
abstract: Recent analyses of the degradation profiles of thousands of proteins by McShane et al. have shown that many proteins are less stable during the hours following their synthesis. Many of such nonexponentially degraded (NED) proteins are components of macromolecular complexes. This may explain why, in cases of trisomy, the effect of overexpression can be attenuated.
authors.affiliation: Institut Jacques Monod, Université Paris Diderot, CNRS UMR7592, Paris 75013, France; Université Paris Diderot-Paris VII, 75205 Paris Cedex 13, France. Electronic address: reiner.veitia@ijm.fr.
authors.forename: Reiner A
authors.initials: RA
authors.lastname: Veitia
mesh_terms: D000375:Aging / Q000378:metabolism*; D006801:Humans; D011506:Proteins / Q000737:chemistry / Q000378:metabolism*
chemical_list: D011506:Proteins