title: Multicentre dose audit for clinical trials of radiation therapy in Asia.
abstract: A dose audit of 16 facilities in 11 countries has been performed within the framework of the Forum for Nuclear Cooperation in Asia (FNCA) quality assurance program. The quality of radiation dosimetry varies because of the large variation in radiation therapy among the participating countries. One of the most important aspects of international multicentre clinical trials is uniformity of absolute dose between centres. The National Institute of Radiological Sciences (NIRS) in Japan has conducted a dose audit of participating countries since 2006 by using radiophotoluminescent glass dosimeters (RGDs). RGDs have been successfully applied to a domestic postal dose audit in Japan. The authors used the same audit system to perform a dose audit of the FNCA countries. The average and standard deviation of the relative deviation between the measured and intended dose among 46 beams was 0.4% and 1.5% (k = 1), respectively. This is an excellent level of uniformity for the multicountry data. However, of the 46 beams measured, a single beam exceeded the permitted tolerance level of ±5%. We investigated the cause for this and solved the problem. This event highlights the importance of external audits in radiation therapy.
authors.affiliation: Department of Radiation Measurement and Dose Assessment,National Institute of Radiological Sciences (NIRS), National Institutes for Quantum and Radiological Science and Technology (QST), 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan.
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Mizuno
authors.affiliation: Department of Radiation Measurement and Dose Assessment,National Institute of Radiological Sciences (NIRS), National Institutes for Quantum and Radiological Science and Technology (QST), 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan.
authors.forename: Shigekazu
authors.initials: S
authors.lastname: Fukuda
authors.affiliation: Department of Radiation Measurement and Dose Assessment,National Institute of Radiological Sciences (NIRS), National Institutes for Quantum and Radiological Science and Technology (QST), 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan.
authors.forename: Akifumi
authors.initials: A
authors.lastname: Fukumura
authors.affiliation: Department of Radiation Measurement and Dose Assessment,National Institute of Radiological Sciences (NIRS), National Institutes for Quantum and Radiological Science and Technology (QST), 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan.
authors.forename: Yuzuru-Kutsutani
authors.initials: YK
authors.lastname: Nakamura
authors.affiliation: Soochow University,China.
authors.forename: Cao
authors.initials: C
authors.lastname: Jianping
authors.affiliation: Korea Institute of Radiological & Medical Sciences (KIRAMS), Korea.
authors.forename: Chul-Koo
authors.initials: CK
authors.lastname: Cho
authors.affiliation: Cipto Mangunkusumo Hospital, Indonesia.
authors.forename: Nana
authors.initials: N
authors.lastname: Supriana
authors.affiliation: National Cancer Hospital, Vietnam.
authors.forename: To Anh
authors.initials: TA
authors.lastname: Dung
authors.affiliation: St Luke's Medical Center, Philippines.
authors.forename: Miriam Joy
authors.initials: MJ
authors.lastname: Calaguas
authors.affiliation: Sarawak General Hospital, Malaysia.
authors.forename: C R Beena
authors.initials: CRB
authors.lastname: Devi
authors.affiliation: Siriraj Hospital, Mahidol University, Thailand.
authors.forename: Yaowalak
authors.initials: Y
authors.lastname: Chansilpa
authors.affiliation: Delta Hospital Ltd, Bangladesh.
authors.forename: Parvin Akhter
authors.initials: PA
authors.lastname: Banu
authors.affiliation: Institute of Nuclear Medicine and Oncology, Pakistan.
authors.forename: Masooma
authors.initials: M
authors.lastname: Riaz
authors.affiliation: Kazakh Research Institute of Oncology and Radiology, Kazakhstan.
authors.forename: Surya
authors.initials: S
authors.lastname: Esentayeva
authors.affiliation: Saitama Medical University International Medical Centre, Japan.
authors.forename: Shingo
authors.initials: S
authors.lastname: Kato
authors.affiliation: Tokyo Women's Medical University Hospital, Japan.
authors.forename: Kumiko
authors.initials: K
authors.lastname: Karasawa
authors.affiliation: Department of Radiation Measurement and Dose Assessment,National Institute of Radiological Sciences (NIRS), National Institutes for Quantum and Radiological Science and Technology (QST), 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan.
authors.forename: Hirohiko
authors.initials: H
authors.lastname: Tsujii
mesh_terms: D001208:Asia; D054869:Clinical Audit; D002986:Clinical Trials as Topic; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D015337:Multicenter Studies as Topic; D011874:Radiometry; D011795:Surveys and Questionnaires
keywords: dose audit; dosimetry; forum for nuclear cooperation in Asia; linac; radiophotoluminescent glass dosimeter