title: Plasma Renalase is Not Associated with Blood Pressure and Brachial-Ankle Pulse Wave Velocity in Chinese Adults With Normal Renal Function.
abstract: OBJECTIVE
  This study aimed to investigate the association of renalase with blood pressure (BP) and brachial-ankle pulse wave velocity (baPWV) in order to better understand the role of renalase in the pathogenesis of hypertension and atherosclerosis.
  
  
  METHODS
  A total of 344 subjects with normal kidney function were recruited from our previously established cohort in Shaanxi Province, China. They were divided into the normotensive (NT) and hypertensive (HT) groups or high baPWV and normal baPWV on the basis of BP levels or baPWV measured with an automatic waveform analyzer. Plasma renalase was determined through an enzyme-linked immunosorbent assay.
  
  
  RESULTS
  Plasma renalase did not significantly differ between HT and NT groups (3.71 ± 0.69 µg/mL vs. 3.72 ± 0.73 μg/mL, P = 0.905) and between subjects with and without high baPWV (3.67 ± 0.66 µg/mL vs. 3.73 ± 0.74 µg/mL, P = 0.505). However, baPWV was significantly higher in the HT group than in the NT group (1460.4 ± 236.7 vs. 1240.7 ± 174.5 cm/s, P < 0.001). Plasma renalase was not correlated with BP levels and baPWV in the entire group. Linear and logistic regression analysis revealed that plasma renalase was not significantly associated with hypertension and high baPWV.
  
  
  CONCLUSIONS
  Plasma renalase may not be associated with BP and baPWV in Chinese subjects with normal renal function.
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Medical School, Xi'an Jiaotong University, Xi'an, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Wang
authors.forename: Yong-Bo
authors.initials: YB
authors.lastname: Lv
authors.forename: Chao
authors.initials: C
authors.lastname: Chu
authors.forename: Man
authors.initials: M
authors.lastname: Wang
authors.forename: Bing-Qing
authors.initials: BQ
authors.lastname: Xie
authors.forename: Lan
authors.initials: L
authors.lastname: Wang
authors.forename: Fan
authors.initials: F
authors.lastname: Yang
authors.forename: Ding-Yi
authors.initials: DY
authors.lastname: Yan
authors.forename: Rui-Hai
authors.initials: RH
authors.lastname: Yang
authors.forename: Jun
authors.initials: J
authors.lastname: Yang
authors.forename: Yong
authors.initials: Y
authors.lastname: Ren
authors.forename: Zu-Yi
authors.initials: ZY
authors.lastname: Yuan
authors.forename: Jian-Jun
authors.initials: JJ
authors.lastname: Mu
mesh_terms: D000328:Adult; D055109:Ankle Brachial Index; D044466:Asian People; D050197:Atherosclerosis / Q000209:etiology; D001794:Blood Pressure; D005260:Female; D006801:Humans; D006973:Hypertension / Q000209:etiology; D007668:Kidney / Q000502:physiology; D008297:Male; D008995:Monoamine Oxidase / Q000097:blood* / Q000502:physiology; D063177:Pulse Wave Analysis
chemical_list: D008995:Monoamine Oxidase; C521557:renalase