title: Echocardiographic changes and growth retardation in a group of Egyptian children with rheumatic heart disease.
abstract: BACKGROUND
  Advances in echocardiographic studies have identified a massive burden of rheumatic heart disease (RHD) which continues to be a major health hazard in most developing countries. The aim of this study was to investigate the correlation between cardiac affection as regards the presence of single or multiple valvular lesions, and their severity and the growth parameters in a group of Egyptian children with RHD.
  
  
  METHODS
  This study is a cross-sectional study, that was conducted on 200 children with RHD and 400 age-matched healthy. All subjects were subjected to anthropometric measurement and echocardiographic evaluation of the different cardiac parameters.
  
  
  RESULTS
  Isolated mitral incompetence (MI) was the most frequent type of valvular lesion in RHD (54.0%), followed by mixed MI and aortic incompetence (AI) (26.5%). Patients with RHD were more liable to be underweight and stunted compared to controls (P<0.05). Growth retardation was significantly noticed in patients with RHD in general (P<0.05), and particularly in patients mixed MI and AI in particular (P<0.05). Also a significant association was detected between growth retardation and the severity of the valvular lesion in the group of rheumatic heart patients (P<0.05).
  
  
  CONCLUSIONS
  Associations between growth retardation and RHD with its various patterns of valvular affection and severity were detected in the present study.
authors.affiliation: Department of Biological Anthropology, National Research Center, Giza, Egypt.
authors.forename: Nayera E
authors.initials: NE
authors.lastname: Hassan
authors.affiliation: Division of Pediatric Cardiology, Department of Pediatrics, Cairo University Children Hospital, Cairo, Egypt.
authors.forename: Hala S
authors.initials: HS
authors.lastname: Hamza
authors.affiliation: Division of Pediatric Cardiology, Department of Pediatrics, Cairo University Children Hospital, Cairo, Egypt - waelped@yahoo.com.
authors.forename: Wael A
authors.initials: WA
authors.lastname: Attia
authors.affiliation: Department of Child Health, National Research Centre, Giza, Egypt.
authors.forename: Moenes M
authors.initials: MM
authors.lastname: Abu Shady
authors.affiliation: Department of Biological Anthropology, National Research Center, Giza, Egypt.
authors.forename: Omar H
authors.initials: OH
authors.lastname: Dwidar
mesh_terms: D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D004452:Echocardiography / Q000379:methods*; D004534:Egypt / Q000453:epidemiology; D005260:Female; D006130:Growth Disorders / Q000453:epidemiology* / Q000209:etiology; D006801:Humans; D008297:Male; D012214:Rheumatic Heart Disease / Q000150:complications / Q000503:physiopathology*; D012720:Severity of Illness Index; D013851:Thinness / Q000453:epidemiology / Q000209:etiology