title: Salivary biomarkers as tools for oral squamous cell carcinoma diagnosis: A systematic review.
abstract: The oral squamous cell carcinoma (OSCC) survival rate is influenced by the fact that diagnoses occur mostly in late stages of the disease. Thus, there is a clear contribution in the early findings, making the use of minimally invasive techniques for diagnosis, such as analysis of salivary markers, interesting tools.
  
  
  
  A systematic review was performed with all studies that establish a comparison between the levels of saliva-based markers found in patients with OSCC compared with cancer-free individuals.
  
  
  
  Twenty-eight studies were included. Of them, only 12 showed some caution with oral conditions before sample collection. A wide range of potential markers was evaluated; however, the comparison between studies was impaired because each marker was hardly explored by more than 1 article.
  
  
  
  The lack of methodological criteria within studies and the absence of consensus on marker choice are obstacles for future researches. © 2016 Wiley Periodicals, Inc. Head Neck 39: 797-811, 2017.
authors.affiliation: Department of Prosthodontics and Periodontology, Discipline of Periodontology, Bauru School of Dentistry, University of São Paulo - Bauru, São Paulo, Brazil.
authors.forename: Vitor T
authors.initials: VT
authors.lastname: Stuani
authors.affiliation: Department of Surgery, Stomatology, Pathology, and Radiology, Discipline of Stomatology, Bauru School of Dentistry, University of São Paulo - Bauru, São Paulo, Brazil.
authors.forename: Cassia M F
authors.initials: CM
authors.lastname: Rubira
authors.affiliation: Department of Prosthodontics and Periodontology, Discipline of Periodontology, Bauru School of Dentistry, University of São Paulo - Bauru, São Paulo, Brazil.
authors.forename: Adriana C P
authors.initials: AC
authors.lastname: Sant'Ana
authors.affiliation: Department of Surgery, Stomatology, Pathology, and Radiology, Discipline of Stomatology, Bauru School of Dentistry, University of São Paulo - Bauru, São Paulo, Brazil.
authors.forename: Paulo S S
authors.initials: PS
authors.lastname: Santos
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000401:mortality / Q000473:pathology*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000473:pathology*; D009361:Neoplasm Invasiveness / Q000473:pathology; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D018570:Risk Assessment; D012463:Saliva / Q000737:chemistry*; D016019:Survival Analysis
chemical_list: D014408:Biomarkers, Tumor
keywords: diagnosis; oral squamous cell carcinoma (OSCC); saliva; salivary biomarkers