title: Effect ofHelicobacter pylorieradication on insulin resistance among prediabetic patients: A pilot study and single-blind randomized controlled clinical trial.
abstract: BACKGROUND
  Type II diabetes mellitus (T2DM) is the prevalent type of diabetes in the world. Prediabetic patients are the most probable group to get diabetes. Several studies have mentioned the role of inflammation in the incidence of diabetes. The origin of inflammation can be infection such asHelicobacter pylori(HP) infection. This study was designed to explore the effect ofHPeradication on insulin resistance.
  
  
  METHODS
  This single-blind randomized controlled clinical trial was conducted in 2014-2015. The sample size consisted of 49 individuals who were in prediabetes stage with HP infection. Patients with positive stool antigen were allocated randomly into two groups. The treatment group took medication to eradicate HP infection by the routine method of four-drug eradication. However, placebo capsules and tablets were given to the patients in the placebo group. Then fasting plasma glucose (FPG), fasting plasma insulin (FPI), and quantitative C-reactive protein (CRP) levels were measured and homeostatic model assessment of insulin resistance (HOMA-IR), homeostatic model assessment of beta-cell function (HOMA-B), Matsuda index, insulinogenic index, and disposition index were calculated.
  
  
  RESULTS
  Results of this study showed that FPI and HOMA-IR increased significantly (Pvalue of FPI = 0.023 andPvalue of HOMA-IR = 0.019) after HP eradication in the treatment group. On the other hand, comparison of differences at the baseline and after 6 weeks in FPG (Pvalue = 0.045), FPI (Pvalue = 0.013), and HOMA-B (Pvalue = 0.038) revealed significant differences between the placebo group and treatment group.
  
  
  CONCLUSIONS
  Results showed that HP eradication by a 2-week antibiotic medication did not decrease insulin resistance and even increased FPI and insulin resistance indices. So HP eradication among prediabetic patients is not recommended for the decrease of insulin resistance and postponement of the development of diabetes mellitus.
authors.affiliation: Department of Endocrinology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Kachuei
authors.affiliation: Department of Endocrinology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Masoud
authors.initials: M
authors.lastname: Amini
authors.affiliation: Department of Gastroenterology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Vahid
authors.initials: V
authors.lastname: Sebghatollahi
authors.affiliation: Department of Biostatistics and Epidemiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Awat
authors.initials: A
authors.lastname: Feizi
authors.affiliation: Department of Endocrinology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Pooria
authors.initials: P
authors.lastname: Hamedani
authors.affiliation: Department of Endocrinology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Bijan
authors.initials: B
authors.lastname: Iraj
keywords: Helicobacter pylori (HP) infection; insulin resistance; prediabetic