title: Interleukin-22 and Cyclosporine in Aggressive Cutaneous Squamous Cell Carcinoma.
abstract: Cutaneous squamous cell carcinomas (SCCs) account for up to 10,000 deaths annually in the United States. Most of the more than 700,000 SCCs diagnosed are cured by excision with clear margins; however, metastasis can occur despite seemingly adequate treatment in some cases. Immune-suppressed organ transplant recipients are 60 to 100 times more likely to develop SCC than immune-competent individuals. Transplant-associated SCCs occur more frequently and behave more aggressively, showing higher risk of recurrence and metastasis. This article identifies a potential role for interleukin-22 in driving SCC proliferation, particularly in solid organ transplant recipients taking cyclosporine.
authors.affiliation: The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, 522 First Avenue, New York, NY 10016, USA.
authors.forename: Alexis L
authors.initials: AL
authors.lastname: Santana
authors.affiliation: Institute for Pediatric Urology, Department of Urology, Weill Cornell Medical College, 1300 York Avenue, Box 94, New York, NY 10065, USA.
authors.forename: Diane
authors.initials: D
authors.lastname: Felsen
authors.affiliation: The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, 522 First Avenue, New York, NY 10016, USA. Electronic address: john.carucci@nyumc.org.
authors.forename: John A
authors.initials: JA
authors.lastname: Carucci
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000139:chemically induced* / Q000276:immunology; D049109:Cell Proliferation; D016572:Cyclosporine / Q000009:adverse effects*; D006084:Graft Rejection / Q000517:prevention & control*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D007378:Interleukins / Q000276:immunology*; D012878:Skin Neoplasms / Q000139:chemically induced* / Q000276:immunology; D066027:Transplant Recipients; D059016:Tumor Microenvironment / Q000276:immunology; D000097043:Interleukin-22
chemical_list: D016572:Cyclosporine; D007166:Immunosuppressive Agents; D007378:Interleukins; D000097043:Interleukin-22
keywords: Cyclosporine; IL-22; Immunosuppression; Nonmelanoma skin cancer; Organ transplant recipient; Squamous cell carcinoma; Transplant-associated squamous cell carcinoma