title: Reaction of Lymphoid Organs to Injection of Iron-Carbon Nanoparticles.
abstract: The distribution of iron-carbon nanoparticles in FeC-DSPE-PEG-2000 modification (micellar particles with structure (Fe) core-carbon shell; PEG-based coating) is studied. The greater part of the nanoparticles accumulated in the spleen and liver, a small amount in the lungs, and the minimum amount in the thymus. The structural changes in the lymphoid organs were minor and involved only the microcirculatory bed. Analysis of the peripheral blood showed manifest anemia, thrombocytopenia, and leukocytosis.
authors.affiliation: Institute of Immunology and Physiology, Ural Division of the Russian Academy of Sciences, Ekaterinburg, Russia. hramtsova15@mail.ru.|B. N. Eltsin Ural Federal University, Ekaterinburg, Russia. hramtsova15@mail.ru.
authors.forename: Yu S
authors.initials: YS
authors.lastname: Khramtsova
authors.affiliation: Institute of Immunology and Physiology, Ural Division of the Russian Academy of Sciences, Ekaterinburg, Russia.|Institute of Medical Cell Technologies, Ekaterinburg, Russia.
authors.forename: N V
authors.initials: NV
authors.lastname: Tyumentseva
authors.affiliation: Institute of Immunology and Physiology, Ural Division of the Russian Academy of Sciences, Ekaterinburg, Russia.|B. N. Eltsin Ural Federal University, Ekaterinburg, Russia.|Institute of Medical Cell Technologies, Ekaterinburg, Russia.
authors.forename: B G
authors.initials: BG
authors.lastname: Yushkov
authors.affiliation: B. N. Eltsin Ural Federal University, Ekaterinburg, Russia.
authors.forename: E A
authors.initials: EA
authors.lastname: Silant'eva
authors.affiliation: Institute of Immunology and Physiology, Ural Division of the Russian Academy of Sciences, Ekaterinburg, Russia.|B. N. Eltsin Ural Federal University, Ekaterinburg, Russia.|Institute of Medical Cell Technologies, Ekaterinburg, Russia.
authors.forename: S Yu
authors.initials: SY
authors.lastname: Medvedeva
authors.affiliation: M. N. Mikheev Institute of Metal Physics, the Ural Division of the Russian Academy of Sciences, Ekaterinburg, Russia.
authors.forename: I V
authors.initials: IV
authors.lastname: Byzov
authors.affiliation: M. N. Mikheev Institute of Metal Physics, the Ural Division of the Russian Academy of Sciences, Ekaterinburg, Russia.
authors.forename: M A
authors.initials: MA
authors.lastname: Uimin
authors.affiliation: M. N. Mikheev Institute of Metal Physics, the Ural Division of the Russian Academy of Sciences, Ekaterinburg, Russia.
authors.forename: A E
authors.initials: AE
authors.lastname: Ermakov
mesh_terms: D000818:Animals; D002244:Carbon / Q000378:metabolism / Q000493:pharmacokinetics*; D004337:Drug Carriers / Q000493:pharmacokinetics*; D004801:Eosine Yellowish-(YS); D006416:Hematoxylin; D006651:Histocytochemistry; D007501:Iron / Q000378:metabolism / Q000493:pharmacokinetics*; D008099:Liver / Q000187:drug effects / Q000648:ultrastructure; D008168:Lung / Q000187:drug effects / Q000648:ultrastructure; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D010714:Phosphatidylethanolamines / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000187:drug effects / Q000648:ultrastructure; D013950:Thymus Gland / Q000187:drug effects / Q000648:ultrastructure; D014018:Tissue Distribution
chemical_list: C519184:1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-methoxy-poly(ethylene glycol 2000); D004337:Drug Carriers; D058185:Magnetite Nanoparticles; D010714:Phosphatidylethanolamines; D011092:Polyethylene Glycols; D002244:Carbon; D007501:Iron; D004801:Eosine Yellowish-(YS); D006416:Hematoxylin
keywords: biodistribution; iron-carbon nanoparticles; lymphoid organs