title: Prognostic Value of Resistive Index in Neonates with Hypoxic Ischemic Encephalopathy.
abstract: OBJECTIVE
  To evaluate the role of Resistive index measured by cranial doppler ultrasonography in predicting the risk of death/ abnormal neurodevelopmental outcomes in term neonates with hypoxic ischemic encephalopathy.
  
  
  METHODS
  We enrolled 50 term asphyxiated neonates with hypoxic ischemic encephalopathy and measured resistive index within 72 hours from the anterior cerebral artery. Participants underwent tone and developmental assessment at 6-12 months.
  
  
  RESULTS
  Among the 50 neonates, 25 (50%) had abnormal resistive index (<0.56 or >0.80). Presence of abnormal resistive index increased the risk of death/ abnormal neurological outcomes at 6-12 months [RR (95% CI): 7.5 (2.0,8.6), P<0.01].
  
  
  CONCLUSIONS
  An abnormal resistive index is associated with death/ neurodevelopmental impairment in neonatal hypoxic ischemic encephalopathy.
authors.affiliation: Department of Neonatology, CHILDS Trust Medical Research Foundation and Kanchi Kamakoti CHILDS Trust Hospital, and *Department of Radiology, Kilpauk Medical College; Chennai, Tamil Nadu, India. Correspondence to: Dr Aparna Chandrasekaran, Department of Neonatology, CHILDS Trust Medical Research Foundation and Kanchi Kamakoti CHILDS Trust Hospital, Nungambakkam, Chennai 600 034, Tamil Nadu, India. appubanu@gmail.com.
authors.forename: A Senthil
authors.initials: AS
authors.lastname: Kumar
authors.forename: Aparna
authors.initials: A
authors.lastname: Chandrasekaran
authors.forename: Rajamannar
authors.initials: R
authors.lastname: Asokan
authors.forename: Kathirvelu
authors.initials: K
authors.lastname: Gopinathan
mesh_terms: D001921:Brain / Q000098:blood supply / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000000981:diagnostic imaging* / Q000401:mortality; D007231:Infant, Newborn; D008297:Male; D011379:Prognosis; D011446:Prospective Studies; D016896:Treatment Outcome; D017585:Ultrasonography, Doppler, Transcranial