title: Gastric and small intestine gastrointestinal stromal tumors: Do outcomes differ?
abstract: OBJECTIVE
  Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. Previous literature has suggested that small intestine GISTs are more aggressive than gastric GISTs. Our primary objective was to compare the outcomes of gastric and small intestine GISTs in the decade after approval of imatinib for treatment.
  
  
  METHODS
  The SEER database was queried for cases of gastric and small intestine GIST between the years 2002 and 2012, using the ICD-O-3 histology code 8936. Survival analysis was performed using generalized gamma models for time to cause-specific mortality (CSM).
  
  
  RESULTS
  CSM was 14.0% for the 3,759 gastric GIST patients and 14.3% for the 1,848 small intestine GIST patients. Five-year survival was 82.2% and 83.3% for gastric and small intestine patients, respectively. The number of diagnosed cases of GIST increased over the course of this study, especially for tumors <5 cm in size and in patients over age 50 years.
  
  
  CONCLUSIONS
  In this large nation-wide study, we found that patients with gastric and small intestine GISTs had similar outcomes, in contrast to previous reports. The diagnosis of GIST has significantly increased in the last decade, which may reflect the increased recognition of this entity and frequent use of imaging. J. Surg. Oncol. 2017;115:351-357. © 2016 Wiley Periodicals, Inc.
authors.affiliation: Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.
authors.forename: Katherine
authors.initials: K
authors.lastname: Giuliano
authors.affiliation: Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.|Department of Surgery, Brigham and Women's Hospital, Boston, Massachusetts.
authors.forename: Neeraja
authors.initials: N
authors.lastname: Nagarajan
authors.affiliation: Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.
authors.forename: Joseph
authors.initials: J
authors.lastname: Canner
authors.affiliation: Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.
authors.forename: Alireza
authors.initials: A
authors.lastname: Najafian
authors.affiliation: Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.
authors.forename: Christopher
authors.initials: C
authors.lastname: Wolfgang
authors.affiliation: Department of Surgery, Brigham and Women's Hospital, Boston, Massachusetts.
authors.forename: Eric
authors.initials: E
authors.lastname: Schneider
authors.affiliation: Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
authors.forename: Christian
authors.initials: C
authors.lastname: Meyer
authors.affiliation: Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.|Department of Gastroenterology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
authors.forename: Anne Marie
authors.initials: AM
authors.lastname: Lennon
authors.affiliation: Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.
authors.forename: Fabian M
authors.initials: FM
authors.lastname: Johnston
authors.affiliation: Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.|Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland.|Department of Urology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
authors.forename: Nita
authors.initials: N
authors.lastname: Ahuja
mesh_terms: D000368:Aged; D005260:Female; D046152:Gastrointestinal Stromal Tumors / Q000188:drug therapy / Q000401:mortality* / Q000473:pathology; D006801:Humans; D007414:Intestinal Neoplasms / Q000188:drug therapy / Q000401:mortality* / Q000473:pathology; D007421:Intestine, Small / Q000473:pathology; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D047428:Protein Kinase Inhibitors / Q000008:administration & dosage; D012042:Registries; D012189:Retrospective Studies; D018426:SEER Program; D013274:Stomach Neoplasms / Q000188:drug therapy / Q000401:mortality* / Q000473:pathology; D014481:United States / Q000453:epidemiology
chemical_list: D047428:Protein Kinase Inhibitors
keywords: GIST; SEER database; gastric GIST; gastrointestinal stromal tumors; small intestine GIST