title: Outcome of Men With Relapse After Adjuvant Carboplatin for Clinical Stage I Seminoma.
abstract: Purpose Adjuvant carboplatin is one of three management strategies that may follow inguinal orchiectomy in clinical stage I seminoma. However, little is known about the outcome of patients who experience a relapse after such treatment. Patients and Methods Data from 185 patients who relapsed after adjuvant carboplatin between January 1987 and August 2013 at 31 centers/groups from 20 countries were collected and retrospectively analyzed. Primary outcomes were disease-free survival and overall survival. Secondary outcomes were time to, stage at, and treatment of relapse as well as rate of subsequent relapses. Results With a median follow-up of 53 months (95% CI, 48 to 60 months) the 5-year disease-free survival was 82% (95% CI, 77% to 89%), and the 5-year overall survival was 98% (95% CI, 95% to 100%). The median time from orchiectomy to relapse was 19 months (95% CI, 17 to 23 months); 15% (95% CI, 10% to 21%) of relapses occurred > 3 years after treatment. The majority of relapses were detected by computed tomography scan during routine follow-up, 98% in the International Germ Cell Cancer Collaborative Group good prognosis group. Chemotherapy was administered to 92% of patients, mostly as standard first-line treatment corresponding to stage; 8% of patients had additional local treatments. Only 28 patients experienced a second relapse. At last follow-up, 174 (94%) of 185 patients were alive without disease, and four patients with disease. Seven patients died, three of whom due to progressive disease. Conclusion Within the limitations of a retrospective analysis, the results suggest that the majority of patients who experience a relapse after adjuvant carboplatin for clinical stage I seminoma can be successfully treated with a cisplatin-based chemotherapy regimen adequate for stage. Because 15% of the relapses occurred > 3 years after adjuvant treatment, a minimum of 5 years follow-up is recommended.
authors.affiliation: Stefanie Fischer and Silke Gillessen, Cantonal Hospital St Gallen, St Gallen; Dirk Klingbiel, SAKK Coordinating Center, Bern; Jörg Beyer, Universitätsspital Zürich, Zürich, Switzerland; Torgrim Tandstad, St Olavs University Hospital, Trondheim, Norway; Matthew Wheater, Caroline Chau, and Edurne Arriola, University Hospital Southampton, Southampton; Emilio Porfiri, Kalena Marti, and Paul Hutton, Birmingham University Hospital, Birmingham; Jonathan Shamash, St Bartholomew's Hospital, London, United Kingdom; Aude Fléchon, Centre Léon Bérard, Lyon; Brigitte Laguerre, Centre Eugène Marquis, Rennes, France; Jorge Aparicio, Hospital Universitari i Politècnic La Fe, Valencia; Pablo Maroto, Hospital Sant Pau, Barcelona, Spain; Breda Skrbinc, Institute of Oncology, Ljubljana, Slovenia; Umberto Basso, Istituto di Ricovero e Cura a Carattere Scientifico, Padova, Italy; Anja Lorch, Universitätsklinikum Düsseldorf, Düsseldorf; Klaus-Peter Dieckmann, Klinik für Urologie, Hamburg, Germany; Gabriella Cohn-Cedermark, Karolinska Institute; Gabriella Cohn-Cedermark, Karolinska University Hospital, Stockholm; and Olof Ståhl, Skane University Hospital, Lund, Sweden.
authors.forename: Stefanie
authors.initials: S
authors.lastname: Fischer
authors.affiliation: Stefanie Fischer and Silke Gillessen, Cantonal Hospital St Gallen, St Gallen; Dirk Klingbiel, SAKK Coordinating Center, Bern; Jörg Beyer, Universitätsspital Zürich, Zürich, Switzerland; Torgrim Tandstad, St Olavs University Hospital, Trondheim, Norway; Matthew Wheater, Caroline Chau, and Edurne Arriola, University Hospital Southampton, Southampton; Emilio Porfiri, Kalena Marti, and Paul Hutton, Birmingham University Hospital, Birmingham; Jonathan Shamash, St Bartholomew's Hospital, London, United Kingdom; Aude Fléchon, Centre Léon Bérard, Lyon; Brigitte Laguerre, Centre Eugène Marquis, Rennes, France; Jorge Aparicio, Hospital Universitari i Politècnic La Fe, Valencia; Pablo Maroto, Hospital Sant Pau, Barcelona, Spain; Breda Skrbinc, Institute of Oncology, Ljubljana, Slovenia; Umberto Basso, Istituto di Ricovero e Cura a Carattere Scientifico, Padova, Italy; Anja Lorch, Universitätsklinikum Düsseldorf, Düsseldorf; Klaus-Peter Dieckmann, Klinik für Urologie, Hamburg, Germany; Gabriella Cohn-Cedermark, Karolinska Institute; Gabriella Cohn-Cedermark, Karolinska University Hospital, Stockholm; and Olof Ståhl, Skane University Hospital, Lund, Sweden.
authors.forename: Torgrim
authors.initials: T
authors.lastname: Tandstad
authors.affiliation: Stefanie Fischer and Silke Gillessen, Cantonal Hospital St Gallen, St Gallen; Dirk Klingbiel, SAKK Coordinating Center, Bern; Jörg Beyer, Universitätsspital Zürich, Zürich, Switzerland; Torgrim Tandstad, St Olavs University Hospital, Trondheim, Norway; Matthew Wheater, Caroline Chau, and Edurne Arriola, University Hospital Southampton, Southampton; Emilio Porfiri, Kalena Marti, and Paul Hutton, Birmingham University Hospital, Birmingham; Jonathan Shamash, St Bartholomew's Hospital, London, United Kingdom; Aude Fléchon, Centre Léon Bérard, Lyon; Brigitte Laguerre, Centre Eugène Marquis, Rennes, France; Jorge Aparicio, Hospital Universitari i Politècnic La Fe, Valencia; Pablo Maroto, Hospital Sant Pau, Barcelona, Spain; Breda Skrbinc, Institute of Oncology, Ljubljana, Slovenia; Umberto Basso, Istituto di Ricovero e Cura a Carattere Scientifico, Padova, Italy; Anja Lorch, Universitätsklinikum Düsseldorf, Düsseldorf; Klaus-Peter Dieckmann, Klinik für Urologie, Hamburg, Germany; Gabriella Cohn-Cedermark, Karolinska Institute; Gabriella Cohn-Cedermark, Karolinska University Hospital, Stockholm; and Olof Ståhl, Skane University Hospital, Lund, Sweden.
authors.forename: Matthew
authors.initials: M
authors.lastname: Wheater
authors.affiliation: Stefanie Fischer and Silke Gillessen, Cantonal Hospital St Gallen, St Gallen; Dirk Klingbiel, SAKK Coordinating Center, Bern; Jörg Beyer, Universitätsspital Zürich, Zürich, Switzerland; Torgrim Tandstad, St Olavs University Hospital, Trondheim, Norway; Matthew Wheater, Caroline Chau, and Edurne Arriola, University Hospital Southampton, Southampton; Emilio Porfiri, Kalena Marti, and Paul Hutton, Birmingham University Hospital, Birmingham; Jonathan Shamash, St Bartholomew's Hospital, London, United Kingdom; Aude Fléchon, Centre Léon Bérard, Lyon; Brigitte Laguerre, Centre Eugène Marquis, Rennes, France; Jorge Aparicio, Hospital Universitari i Politècnic La Fe, Valencia; Pablo Maroto, Hospital Sant Pau, Barcelona, Spain; Breda Skrbinc, Institute of Oncology, Ljubljana, Slovenia; Umberto Basso, Istituto di Ricovero e Cura a Carattere Scientifico, Padova, Italy; Anja Lorch, Universitätsklinikum Düsseldorf, Düsseldorf; Klaus-Peter Dieckmann, Klinik für Urologie, Hamburg, Germany; Gabriella Cohn-Cedermark, Karolinska Institute; Gabriella Cohn-Cedermark, Karolinska University Hospital, Stockholm; and Olof Ståhl, Skane University Hospital, Lund, Sweden.
authors.forename: Emilio
authors.initials: E
authors.lastname: Porfiri
authors.affiliation: Stefanie Fischer and Silke Gillessen, Cantonal Hospital St Gallen, St Gallen; Dirk Klingbiel, SAKK Coordinating Center, Bern; Jörg Beyer, Universitätsspital Zürich, Zürich, Switzerland; Torgrim Tandstad, St Olavs University Hospital, Trondheim, Norway; Matthew Wheater, Caroline Chau, and Edurne Arriola, University Hospital Southampton, Southampton; Emilio Porfiri, Kalena Marti, and Paul Hutton, Birmingham University Hospital, Birmingham; Jonathan Shamash, St Bartholomew's Hospital, London, United Kingdom; Aude Fléchon, Centre Léon Bérard, Lyon; Brigitte Laguerre, Centre Eugène Marquis, Rennes, France; Jorge Aparicio, Hospital Universitari i Politècnic La Fe, Valencia; Pablo Maroto, Hospital Sant Pau, Barcelona, Spain; Breda Skrbinc, Institute of Oncology, Ljubljana, Slovenia; Umberto Basso, Istituto di Ricovero e Cura a Carattere Scientifico, Padova, Italy; Anja Lorch, Universitätsklinikum Düsseldorf, Düsseldorf; Klaus-Peter Dieckmann, Klinik für Urologie, Hamburg, Germany; Gabriella Cohn-Cedermark, Karolinska Institute; Gabriella Cohn-Cedermark, Karolinska University Hospital, Stockholm; and Olof Ståhl, Skane University Hospital, Lund, Sweden.
authors.forename: Aude
authors.initials: A
authors.lastname: Fléchon
authors.affiliation: Stefanie Fischer and Silke Gillessen, Cantonal Hospital St Gallen, St Gallen; Dirk Klingbiel, SAKK Coordinating Center, Bern; Jörg Beyer, Universitätsspital Zürich, Zürich, Switzerland; Torgrim Tandstad, St Olavs University Hospital, Trondheim, Norway; Matthew Wheater, Caroline Chau, and Edurne Arriola, University Hospital Southampton, Southampton; Emilio Porfiri, Kalena Marti, and Paul Hutton, Birmingham University Hospital, Birmingham; Jonathan Shamash, St Bartholomew's Hospital, London, United Kingdom; Aude Fléchon, Centre Léon Bérard, Lyon; Brigitte Laguerre, Centre Eugène Marquis, Rennes, France; Jorge Aparicio, Hospital Universitari i Politècnic La Fe, Valencia; Pablo Maroto, Hospital Sant Pau, Barcelona, Spain; Breda Skrbinc, Institute of Oncology, Ljubljana, Slovenia; Umberto Basso, Istituto di Ricovero e Cura a Carattere Scientifico, Padova, Italy; Anja Lorch, Universitätsklinikum Düsseldorf, Düsseldorf; Klaus-Peter Dieckmann, Klinik für Urologie, Hamburg, Germany; Gabriella Cohn-Cedermark, Karolinska Institute; Gabriella Cohn-Cedermark, Karolinska University Hospital, Stockholm; and Olof Ståhl, Skane University Hospital, Lund, Sweden.
authors.forename: Jorge
authors.initials: J
authors.lastname: Aparicio
authors.affiliation: Stefanie Fischer and Silke Gillessen, Cantonal Hospital St Gallen, St Gallen; Dirk Klingbiel, SAKK Coordinating Center, Bern; Jörg Beyer, Universitätsspital Zürich, Zürich, Switzerland; Torgrim Tandstad, St Olavs University Hospital, Trondheim, Norway; Matthew Wheater, Caroline Chau, and Edurne Arriola, University Hospital Southampton, Southampton; Emilio Porfiri, Kalena Marti, and Paul Hutton, Birmingham University Hospital, Birmingham; Jonathan Shamash, St Bartholomew's Hospital, London, United Kingdom; Aude Fléchon, Centre Léon Bérard, Lyon; Brigitte Laguerre, Centre Eugène Marquis, Rennes, France; Jorge Aparicio, Hospital Universitari i Politècnic La Fe, Valencia; Pablo Maroto, Hospital Sant Pau, Barcelona, Spain; Breda Skrbinc, Institute of Oncology, Ljubljana, Slovenia; Umberto Basso, Istituto di Ricovero e Cura a Carattere Scientifico, Padova, Italy; Anja Lorch, Universitätsklinikum Düsseldorf, Düsseldorf; Klaus-Peter Dieckmann, Klinik für Urologie, Hamburg, Germany; Gabriella Cohn-Cedermark, Karolinska Institute; Gabriella Cohn-Cedermark, Karolinska University Hospital, Stockholm; and Olof Ståhl, Skane University Hospital, Lund, Sweden.
authors.forename: Dirk
authors.initials: D
authors.lastname: Klingbiel
authors.affiliation: Stefanie Fischer and Silke Gillessen, Cantonal Hospital St Gallen, St Gallen; Dirk Klingbiel, SAKK Coordinating Center, Bern; Jörg Beyer, Universitätsspital Zürich, Zürich, Switzerland; Torgrim Tandstad, St Olavs University Hospital, Trondheim, Norway; Matthew Wheater, Caroline Chau, and Edurne Arriola, University Hospital Southampton, Southampton; Emilio Porfiri, Kalena Marti, and Paul Hutton, Birmingham University Hospital, Birmingham; Jonathan Shamash, St Bartholomew's Hospital, London, United Kingdom; Aude Fléchon, Centre Léon Bérard, Lyon; Brigitte Laguerre, Centre Eugène Marquis, Rennes, France; Jorge Aparicio, Hospital Universitari i Politècnic La Fe, Valencia; Pablo Maroto, Hospital Sant Pau, Barcelona, Spain; Breda Skrbinc, Institute of Oncology, Ljubljana, Slovenia; Umberto Basso, Istituto di Ricovero e Cura a Carattere Scientifico, Padova, Italy; Anja Lorch, Universitätsklinikum Düsseldorf, Düsseldorf; Klaus-Peter Dieckmann, Klinik für Urologie, Hamburg, Germany; Gabriella Cohn-Cedermark, Karolinska Institute; Gabriella Cohn-Cedermark, Karolinska University Hospital, Stockholm; and Olof Ståhl, Skane University Hospital, Lund, Sweden.
authors.forename: Breda
authors.initials: B
authors.lastname: Skrbinc
authors.affiliation: Stefanie Fischer and Silke Gillessen, Cantonal Hospital St Gallen, St Gallen; Dirk Klingbiel, SAKK Coordinating Center, Bern; Jörg Beyer, Universitätsspital Zürich, Zürich, Switzerland; Torgrim Tandstad, St Olavs University Hospital, Trondheim, Norway; Matthew Wheater, Caroline Chau, and Edurne Arriola, University Hospital Southampton, Southampton; Emilio Porfiri, Kalena Marti, and Paul Hutton, Birmingham University Hospital, Birmingham; Jonathan Shamash, St Bartholomew's Hospital, London, United Kingdom; Aude Fléchon, Centre Léon Bérard, Lyon; Brigitte Laguerre, Centre Eugène Marquis, Rennes, France; Jorge Aparicio, Hospital Universitari i Politècnic La Fe, Valencia; Pablo Maroto, Hospital Sant Pau, Barcelona, Spain; Breda Skrbinc, Institute of Oncology, Ljubljana, Slovenia; Umberto Basso, Istituto di Ricovero e Cura a Carattere Scientifico, Padova, Italy; Anja Lorch, Universitätsklinikum Düsseldorf, Düsseldorf; Klaus-Peter Dieckmann, Klinik für Urologie, Hamburg, Germany; Gabriella Cohn-Cedermark, Karolinska Institute; Gabriella Cohn-Cedermark, Karolinska University Hospital, Stockholm; and Olof Ståhl, Skane University Hospital, Lund, Sweden.
authors.forename: Umberto
authors.initials: U
authors.lastname: Basso
authors.affiliation: Stefanie Fischer and Silke Gillessen, Cantonal Hospital St Gallen, St Gallen; Dirk Klingbiel, SAKK Coordinating Center, Bern; Jörg Beyer, Universitätsspital Zürich, Zürich, Switzerland; Torgrim Tandstad, St Olavs University Hospital, Trondheim, Norway; Matthew Wheater, Caroline Chau, and Edurne Arriola, University Hospital Southampton, Southampton; Emilio Porfiri, Kalena Marti, and Paul Hutton, Birmingham University Hospital, Birmingham; Jonathan Shamash, St Bartholomew's Hospital, London, United Kingdom; Aude Fléchon, Centre Léon Bérard, Lyon; Brigitte Laguerre, Centre Eugène Marquis, Rennes, France; Jorge Aparicio, Hospital Universitari i Politècnic La Fe, Valencia; Pablo Maroto, Hospital Sant Pau, Barcelona, Spain; Breda Skrbinc, Institute of Oncology, Ljubljana, Slovenia; Umberto Basso, Istituto di Ricovero e Cura a Carattere Scientifico, Padova, Italy; Anja Lorch, Universitätsklinikum Düsseldorf, Düsseldorf; Klaus-Peter Dieckmann, Klinik für Urologie, Hamburg, Germany; Gabriella Cohn-Cedermark, Karolinska Institute; Gabriella Cohn-Cedermark, Karolinska University Hospital, Stockholm; and Olof Ståhl, Skane University Hospital, Lund, Sweden.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Shamash
authors.affiliation: Stefanie Fischer and Silke Gillessen, Cantonal Hospital St Gallen, St Gallen; Dirk Klingbiel, SAKK Coordinating Center, Bern; Jörg Beyer, Universitätsspital Zürich, Zürich, Switzerland; Torgrim Tandstad, St Olavs University Hospital, Trondheim, Norway; Matthew Wheater, Caroline Chau, and Edurne Arriola, University Hospital Southampton, Southampton; Emilio Porfiri, Kalena Marti, and Paul Hutton, Birmingham University Hospital, Birmingham; Jonathan Shamash, St Bartholomew's Hospital, London, United Kingdom; Aude Fléchon, Centre Léon Bérard, Lyon; Brigitte Laguerre, Centre Eugène Marquis, Rennes, France; Jorge Aparicio, Hospital Universitari i Politècnic La Fe, Valencia; Pablo Maroto, Hospital Sant Pau, Barcelona, Spain; Breda Skrbinc, Institute of Oncology, Ljubljana, Slovenia; Umberto Basso, Istituto di Ricovero e Cura a Carattere Scientifico, Padova, Italy; Anja Lorch, Universitätsklinikum Düsseldorf, Düsseldorf; Klaus-Peter Dieckmann, Klinik für Urologie, Hamburg, Germany; Gabriella Cohn-Cedermark, Karolinska Institute; Gabriella Cohn-Cedermark, Karolinska University Hospital, Stockholm; and Olof Ståhl, Skane University Hospital, Lund, Sweden.
authors.forename: Anja
authors.initials: A
authors.lastname: Lorch
authors.affiliation: Stefanie Fischer and Silke Gillessen, Cantonal Hospital St Gallen, St Gallen; Dirk Klingbiel, SAKK Coordinating Center, Bern; Jörg Beyer, Universitätsspital Zürich, Zürich, Switzerland; Torgrim Tandstad, St Olavs University Hospital, Trondheim, Norway; Matthew Wheater, Caroline Chau, and Edurne Arriola, University Hospital Southampton, Southampton; Emilio Porfiri, Kalena Marti, and Paul Hutton, Birmingham University Hospital, Birmingham; Jonathan Shamash, St Bartholomew's Hospital, London, United Kingdom; Aude Fléchon, Centre Léon Bérard, Lyon; Brigitte Laguerre, Centre Eugène Marquis, Rennes, France; Jorge Aparicio, Hospital Universitari i Politècnic La Fe, Valencia; Pablo Maroto, Hospital Sant Pau, Barcelona, Spain; Breda Skrbinc, Institute of Oncology, Ljubljana, Slovenia; Umberto Basso, Istituto di Ricovero e Cura a Carattere Scientifico, Padova, Italy; Anja Lorch, Universitätsklinikum Düsseldorf, Düsseldorf; Klaus-Peter Dieckmann, Klinik für Urologie, Hamburg, Germany; Gabriella Cohn-Cedermark, Karolinska Institute; Gabriella Cohn-Cedermark, Karolinska University Hospital, Stockholm; and Olof Ståhl, Skane University Hospital, Lund, Sweden.
authors.forename: Klaus-Peter
authors.initials: KP
authors.lastname: Dieckmann
authors.affiliation: Stefanie Fischer and Silke Gillessen, Cantonal Hospital St Gallen, St Gallen; Dirk Klingbiel, SAKK Coordinating Center, Bern; Jörg Beyer, Universitätsspital Zürich, Zürich, Switzerland; Torgrim Tandstad, St Olavs University Hospital, Trondheim, Norway; Matthew Wheater, Caroline Chau, and Edurne Arriola, University Hospital Southampton, Southampton; Emilio Porfiri, Kalena Marti, and Paul Hutton, Birmingham University Hospital, Birmingham; Jonathan Shamash, St Bartholomew's Hospital, London, United Kingdom; Aude Fléchon, Centre Léon Bérard, Lyon; Brigitte Laguerre, Centre Eugène Marquis, Rennes, France; Jorge Aparicio, Hospital Universitari i Politècnic La Fe, Valencia; Pablo Maroto, Hospital Sant Pau, Barcelona, Spain; Breda Skrbinc, Institute of Oncology, Ljubljana, Slovenia; Umberto Basso, Istituto di Ricovero e Cura a Carattere Scientifico, Padova, Italy; Anja Lorch, Universitätsklinikum Düsseldorf, Düsseldorf; Klaus-Peter Dieckmann, Klinik für Urologie, Hamburg, Germany; Gabriella Cohn-Cedermark, Karolinska Institute; Gabriella Cohn-Cedermark, Karolinska University Hospital, Stockholm; and Olof Ståhl, Skane University Hospital, Lund, Sweden.
authors.forename: Gabriella
authors.initials: G
authors.lastname: Cohn-Cedermark
authors.affiliation: Stefanie Fischer and Silke Gillessen, Cantonal Hospital St Gallen, St Gallen; Dirk Klingbiel, SAKK Coordinating Center, Bern; Jörg Beyer, Universitätsspital Zürich, Zürich, Switzerland; Torgrim Tandstad, St Olavs University Hospital, Trondheim, Norway; Matthew Wheater, Caroline Chau, and Edurne Arriola, University Hospital Southampton, Southampton; Emilio Porfiri, Kalena Marti, and Paul Hutton, Birmingham University Hospital, Birmingham; Jonathan Shamash, St Bartholomew's Hospital, London, United Kingdom; Aude Fléchon, Centre Léon Bérard, Lyon; Brigitte Laguerre, Centre Eugène Marquis, Rennes, France; Jorge Aparicio, Hospital Universitari i Politècnic La Fe, Valencia; Pablo Maroto, Hospital Sant Pau, Barcelona, Spain; Breda Skrbinc, Institute of Oncology, Ljubljana, Slovenia; Umberto Basso, Istituto di Ricovero e Cura a Carattere Scientifico, Padova, Italy; Anja Lorch, Universitätsklinikum Düsseldorf, Düsseldorf; Klaus-Peter Dieckmann, Klinik für Urologie, Hamburg, Germany; Gabriella Cohn-Cedermark, Karolinska Institute; Gabriella Cohn-Cedermark, Karolinska University Hospital, Stockholm; and Olof Ståhl, Skane University Hospital, Lund, Sweden.
authors.forename: Olof
authors.initials: O
authors.lastname: Ståhl
authors.affiliation: Stefanie Fischer and Silke Gillessen, Cantonal Hospital St Gallen, St Gallen; Dirk Klingbiel, SAKK Coordinating Center, Bern; Jörg Beyer, Universitätsspital Zürich, Zürich, Switzerland; Torgrim Tandstad, St Olavs University Hospital, Trondheim, Norway; Matthew Wheater, Caroline Chau, and Edurne Arriola, University Hospital Southampton, Southampton; Emilio Porfiri, Kalena Marti, and Paul Hutton, Birmingham University Hospital, Birmingham; Jonathan Shamash, St Bartholomew's Hospital, London, United Kingdom; Aude Fléchon, Centre Léon Bérard, Lyon; Brigitte Laguerre, Centre Eugène Marquis, Rennes, France; Jorge Aparicio, Hospital Universitari i Politècnic La Fe, Valencia; Pablo Maroto, Hospital Sant Pau, Barcelona, Spain; Breda Skrbinc, Institute of Oncology, Ljubljana, Slovenia; Umberto Basso, Istituto di Ricovero e Cura a Carattere Scientifico, Padova, Italy; Anja Lorch, Universitätsklinikum Düsseldorf, Düsseldorf; Klaus-Peter Dieckmann, Klinik für Urologie, Hamburg, Germany; Gabriella Cohn-Cedermark, Karolinska Institute; Gabriella Cohn-Cedermark, Karolinska University Hospital, Stockholm; and Olof Ståhl, Skane University Hospital, Lund, Sweden.
authors.forename: Caroline
authors.initials: C
authors.lastname: Chau
authors.affiliation: Stefanie Fischer and Silke Gillessen, Cantonal Hospital St Gallen, St Gallen; Dirk Klingbiel, SAKK Coordinating Center, Bern; Jörg Beyer, Universitätsspital Zürich, Zürich, Switzerland; Torgrim Tandstad, St Olavs University Hospital, Trondheim, Norway; Matthew Wheater, Caroline Chau, and Edurne Arriola, University Hospital Southampton, Southampton; Emilio Porfiri, Kalena Marti, and Paul Hutton, Birmingham University Hospital, Birmingham; Jonathan Shamash, St Bartholomew's Hospital, London, United Kingdom; Aude Fléchon, Centre Léon Bérard, Lyon; Brigitte Laguerre, Centre Eugène Marquis, Rennes, France; Jorge Aparicio, Hospital Universitari i Politècnic La Fe, Valencia; Pablo Maroto, Hospital Sant Pau, Barcelona, Spain; Breda Skrbinc, Institute of Oncology, Ljubljana, Slovenia; Umberto Basso, Istituto di Ricovero e Cura a Carattere Scientifico, Padova, Italy; Anja Lorch, Universitätsklinikum Düsseldorf, Düsseldorf; Klaus-Peter Dieckmann, Klinik für Urologie, Hamburg, Germany; Gabriella Cohn-Cedermark, Karolinska Institute; Gabriella Cohn-Cedermark, Karolinska University Hospital, Stockholm; and Olof Ståhl, Skane University Hospital, Lund, Sweden.
authors.forename: Edurne
authors.initials: E
authors.lastname: Arriola
authors.affiliation: Stefanie Fischer and Silke Gillessen, Cantonal Hospital St Gallen, St Gallen; Dirk Klingbiel, SAKK Coordinating Center, Bern; Jörg Beyer, Universitätsspital Zürich, Zürich, Switzerland; Torgrim Tandstad, St Olavs University Hospital, Trondheim, Norway; Matthew Wheater, Caroline Chau, and Edurne Arriola, University Hospital Southampton, Southampton; Emilio Porfiri, Kalena Marti, and Paul Hutton, Birmingham University Hospital, Birmingham; Jonathan Shamash, St Bartholomew's Hospital, London, United Kingdom; Aude Fléchon, Centre Léon Bérard, Lyon; Brigitte Laguerre, Centre Eugène Marquis, Rennes, France; Jorge Aparicio, Hospital Universitari i Politècnic La Fe, Valencia; Pablo Maroto, Hospital Sant Pau, Barcelona, Spain; Breda Skrbinc, Institute of Oncology, Ljubljana, Slovenia; Umberto Basso, Istituto di Ricovero e Cura a Carattere Scientifico, Padova, Italy; Anja Lorch, Universitätsklinikum Düsseldorf, Düsseldorf; Klaus-Peter Dieckmann, Klinik für Urologie, Hamburg, Germany; Gabriella Cohn-Cedermark, Karolinska Institute; Gabriella Cohn-Cedermark, Karolinska University Hospital, Stockholm; and Olof Ståhl, Skane University Hospital, Lund, Sweden.
authors.forename: Kalena
authors.initials: K
authors.lastname: Marti
authors.affiliation: Stefanie Fischer and Silke Gillessen, Cantonal Hospital St Gallen, St Gallen; Dirk Klingbiel, SAKK Coordinating Center, Bern; Jörg Beyer, Universitätsspital Zürich, Zürich, Switzerland; Torgrim Tandstad, St Olavs University Hospital, Trondheim, Norway; Matthew Wheater, Caroline Chau, and Edurne Arriola, University Hospital Southampton, Southampton; Emilio Porfiri, Kalena Marti, and Paul Hutton, Birmingham University Hospital, Birmingham; Jonathan Shamash, St Bartholomew's Hospital, London, United Kingdom; Aude Fléchon, Centre Léon Bérard, Lyon; Brigitte Laguerre, Centre Eugène Marquis, Rennes, France; Jorge Aparicio, Hospital Universitari i Politècnic La Fe, Valencia; Pablo Maroto, Hospital Sant Pau, Barcelona, Spain; Breda Skrbinc, Institute of Oncology, Ljubljana, Slovenia; Umberto Basso, Istituto di Ricovero e Cura a Carattere Scientifico, Padova, Italy; Anja Lorch, Universitätsklinikum Düsseldorf, Düsseldorf; Klaus-Peter Dieckmann, Klinik für Urologie, Hamburg, Germany; Gabriella Cohn-Cedermark, Karolinska Institute; Gabriella Cohn-Cedermark, Karolinska University Hospital, Stockholm; and Olof Ståhl, Skane University Hospital, Lund, Sweden.
authors.forename: Paul
authors.initials: P
authors.lastname: Hutton
authors.affiliation: Stefanie Fischer and Silke Gillessen, Cantonal Hospital St Gallen, St Gallen; Dirk Klingbiel, SAKK Coordinating Center, Bern; Jörg Beyer, Universitätsspital Zürich, Zürich, Switzerland; Torgrim Tandstad, St Olavs University Hospital, Trondheim, Norway; Matthew Wheater, Caroline Chau, and Edurne Arriola, University Hospital Southampton, Southampton; Emilio Porfiri, Kalena Marti, and Paul Hutton, Birmingham University Hospital, Birmingham; Jonathan Shamash, St Bartholomew's Hospital, London, United Kingdom; Aude Fléchon, Centre Léon Bérard, Lyon; Brigitte Laguerre, Centre Eugène Marquis, Rennes, France; Jorge Aparicio, Hospital Universitari i Politècnic La Fe, Valencia; Pablo Maroto, Hospital Sant Pau, Barcelona, Spain; Breda Skrbinc, Institute of Oncology, Ljubljana, Slovenia; Umberto Basso, Istituto di Ricovero e Cura a Carattere Scientifico, Padova, Italy; Anja Lorch, Universitätsklinikum Düsseldorf, Düsseldorf; Klaus-Peter Dieckmann, Klinik für Urologie, Hamburg, Germany; Gabriella Cohn-Cedermark, Karolinska Institute; Gabriella Cohn-Cedermark, Karolinska University Hospital, Stockholm; and Olof Ståhl, Skane University Hospital, Lund, Sweden.
authors.forename: Brigitte
authors.initials: B
authors.lastname: Laguerre
authors.affiliation: Stefanie Fischer and Silke Gillessen, Cantonal Hospital St Gallen, St Gallen; Dirk Klingbiel, SAKK Coordinating Center, Bern; Jörg Beyer, Universitätsspital Zürich, Zürich, Switzerland; Torgrim Tandstad, St Olavs University Hospital, Trondheim, Norway; Matthew Wheater, Caroline Chau, and Edurne Arriola, University Hospital Southampton, Southampton; Emilio Porfiri, Kalena Marti, and Paul Hutton, Birmingham University Hospital, Birmingham; Jonathan Shamash, St Bartholomew's Hospital, London, United Kingdom; Aude Fléchon, Centre Léon Bérard, Lyon; Brigitte Laguerre, Centre Eugène Marquis, Rennes, France; Jorge Aparicio, Hospital Universitari i Politècnic La Fe, Valencia; Pablo Maroto, Hospital Sant Pau, Barcelona, Spain; Breda Skrbinc, Institute of Oncology, Ljubljana, Slovenia; Umberto Basso, Istituto di Ricovero e Cura a Carattere Scientifico, Padova, Italy; Anja Lorch, Universitätsklinikum Düsseldorf, Düsseldorf; Klaus-Peter Dieckmann, Klinik für Urologie, Hamburg, Germany; Gabriella Cohn-Cedermark, Karolinska Institute; Gabriella Cohn-Cedermark, Karolinska University Hospital, Stockholm; and Olof Ståhl, Skane University Hospital, Lund, Sweden.
authors.forename: Pablo
authors.initials: P
authors.lastname: Maroto
authors.affiliation: Stefanie Fischer and Silke Gillessen, Cantonal Hospital St Gallen, St Gallen; Dirk Klingbiel, SAKK Coordinating Center, Bern; Jörg Beyer, Universitätsspital Zürich, Zürich, Switzerland; Torgrim Tandstad, St Olavs University Hospital, Trondheim, Norway; Matthew Wheater, Caroline Chau, and Edurne Arriola, University Hospital Southampton, Southampton; Emilio Porfiri, Kalena Marti, and Paul Hutton, Birmingham University Hospital, Birmingham; Jonathan Shamash, St Bartholomew's Hospital, London, United Kingdom; Aude Fléchon, Centre Léon Bérard, Lyon; Brigitte Laguerre, Centre Eugène Marquis, Rennes, France; Jorge Aparicio, Hospital Universitari i Politècnic La Fe, Valencia; Pablo Maroto, Hospital Sant Pau, Barcelona, Spain; Breda Skrbinc, Institute of Oncology, Ljubljana, Slovenia; Umberto Basso, Istituto di Ricovero e Cura a Carattere Scientifico, Padova, Italy; Anja Lorch, Universitätsklinikum Düsseldorf, Düsseldorf; Klaus-Peter Dieckmann, Klinik für Urologie, Hamburg, Germany; Gabriella Cohn-Cedermark, Karolinska Institute; Gabriella Cohn-Cedermark, Karolinska University Hospital, Stockholm; and Olof Ståhl, Skane University Hospital, Lund, Sweden.
authors.forename: Jörg
authors.initials: J
authors.lastname: Beyer
authors.affiliation: Stefanie Fischer and Silke Gillessen, Cantonal Hospital St Gallen, St Gallen; Dirk Klingbiel, SAKK Coordinating Center, Bern; Jörg Beyer, Universitätsspital Zürich, Zürich, Switzerland; Torgrim Tandstad, St Olavs University Hospital, Trondheim, Norway; Matthew Wheater, Caroline Chau, and Edurne Arriola, University Hospital Southampton, Southampton; Emilio Porfiri, Kalena Marti, and Paul Hutton, Birmingham University Hospital, Birmingham; Jonathan Shamash, St Bartholomew's Hospital, London, United Kingdom; Aude Fléchon, Centre Léon Bérard, Lyon; Brigitte Laguerre, Centre Eugène Marquis, Rennes, France; Jorge Aparicio, Hospital Universitari i Politècnic La Fe, Valencia; Pablo Maroto, Hospital Sant Pau, Barcelona, Spain; Breda Skrbinc, Institute of Oncology, Ljubljana, Slovenia; Umberto Basso, Istituto di Ricovero e Cura a Carattere Scientifico, Padova, Italy; Anja Lorch, Universitätsklinikum Düsseldorf, Düsseldorf; Klaus-Peter Dieckmann, Klinik für Urologie, Hamburg, Germany; Gabriella Cohn-Cedermark, Karolinska Institute; Gabriella Cohn-Cedermark, Karolinska University Hospital, Stockholm; and Olof Ståhl, Skane University Hospital, Lund, Sweden.
authors.forename: Silke
authors.initials: S
authors.lastname: Gillessen
mesh_terms: D000328:Adult; D000368:Aged; D016190:Carboplatin / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009919:Orchiectomy; D012008:Recurrence; D018239:Seminoma / Q000401:mortality / Q000628:therapy*; D013736:Testicular Neoplasms / Q000401:mortality / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D016190:Carboplatin