title: Sentinel case of Richter transformation from chronic lymphocytic leukaemia/small lymphocytic lymphoma to CD3+ diffuse large B-cell lymphoma.
abstract: OBJECTIVE
  To report the first case of a Richter syndrome where small lymphocytic lymphoma (SLL) progressed to a CD3+ diffuse large B-cell lymphoma (DLBCL).
  
  
  METHODS
  Macrodissection of small and large cell lymphomatous components was performed. This was followed by flow cytometric analysis along with molecular B-cell immunoglobulin (heavy and light chains) and T-cell receptor (γ and β chains) gene rearrangement studies to investigate a clonal relationship between the components.
  
  
  RESULTS
  The immunophenotypic profile was similar between small and large cell components of the lymphoma by flow cytometry. Furthermore, shared clonal peaks were observed between both components based on molecular B-cell and T-cell receptor gene rearrangement studies, confirming a clonal relationship.
  
  
  CONCLUSIONS
  Chronic lymphocytic leukaemia/SLL may rarely undergo Richter transformation to a DLBCL demonstrating lineage infidelity. This is a potentially important diagnostic pitfall and such cases should not be confused with a de novo T-cell lymphoma.
authors.affiliation: University of Pikeville Kentucky College of Osteopathic Medicine, Pikeville, Kentucky, USA.
authors.forename: Ali
authors.initials: A
authors.lastname: Ismail
authors.affiliation: Moffitt Cancer Center, Tampa, Florida, USA.
authors.forename: Jawed A
authors.initials: JA
authors.lastname: Mallick
authors.affiliation: Moffitt Cancer Center, Tampa, Florida, USA.
authors.forename: Dahui
authors.initials: D
authors.lastname: Qin
authors.affiliation: Moffitt Cancer Center, Tampa, Florida, USA.
authors.forename: Mohammad O
authors.initials: MO
authors.lastname: Hussaini
mesh_terms: D000369:Aged, 80 and over; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D005434:Flow Cytometry; D006258:Head and Neck Neoplasms / Q000473:pathology*; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000473:pathology*; D008207:Lymphatic Metastasis; D016403:Lymphoma, Large B-Cell, Diffuse / Q000473:pathology*; D008297:Male
keywords: HEMATOPATHOLOGY; LYMPHOMA; MOLECULAR PATHOLOGY