title: Improvement in Thermal Stability of Sucralose by γ-Cyclodextrin Metal-Organic Frameworks.
abstract: To explain thermal stability enhancement of an organic compound, sucralose, with cyclodextrin based metal organic frameworks.
  
  
  
  Micron and nanometer sized basic CD-MOFs were successfully synthesized by a modified vapor diffusion method and further neutralized with glacial acetic acid. Sucralose was loaded into CD-MOFs by incubating CD-MOFs with sucralose ethanol solutions. Thermal stabilities of sucralose-loaded basic CD-MOFs and neutralized CD-MOFs were investigated using thermogravimetric analysis (TGA), differential scanning calorimetry (DSC) and high performance liquid chromatography with evaporative light-scattering detection (HPLC-ELSD).
  
  
  
  Scanning electron microscopy (SEM) and powder X-ray diffraction (PXRD) results showed that basic CD-MOFs were cubic crystals with smooth surface and uniform sizes. The basic CD-MOFs maintained their crystalline structure after neutralization. HPLC-ELSD analysis indicated that the CD-MOF crystal size had significant influence on sucralose loading (SL). The maximal SL of micron CD-MOFs (CD-MOF-Micro) was 17.5 ± 0.9% (w/w). In contrast, 27.9 ± 1.4% of sucralose could be loaded in nanometer-sized basic CD-MOFs (CD-MOF-Nano). Molecular docking modeling showed that sucralose molecules preferentially located inside the cavities of γ-CDs pairs in CD-MOFs. Raw sucralose decomposed fast at 90°C, with 86.2 ± 0.2% of the compound degraded within only 1 h. Remarkably, sucralose stability was dramatically improved after loading in neutralized CD-MOFs, with only 13.7 ± 0.7% degradation at 90°C within 24 h.
  
  
  
  CD-MOFs efficiently incorporated sucralose and maintained its integrity upon heating at elevated temperatures.
authors.affiliation: School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, China.|Center for Drug Delivery System, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, No. 501 of Haike Road, Shanghai, 201210, China.
authors.forename: Nana
authors.initials: N
authors.lastname: Lv
authors.affiliation: Center for Drug Delivery System, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, No. 501 of Haike Road, Shanghai, 201210, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Guo
authors.affiliation: Center for Drug Delivery System, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, No. 501 of Haike Road, Shanghai, 201210, China.|School of Chemical and Environmental Engineering, Shanghai Institute of Technology, Shanghai, 201418, China.
authors.forename: Botao
authors.initials: B
authors.lastname: Liu
authors.affiliation: Center for Drug Delivery System, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, No. 501 of Haike Road, Shanghai, 201210, China.
authors.forename: Caifen
authors.initials: C
authors.lastname: Wang
authors.affiliation: Center for Drug Delivery System, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, No. 501 of Haike Road, Shanghai, 201210, China.
authors.forename: Vikaramjeet
authors.initials: V
authors.lastname: Singh
authors.affiliation: School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, China.|Center for Drug Delivery System, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, No. 501 of Haike Road, Shanghai, 201210, China.
authors.forename: Xiaonan
authors.initials: X
authors.lastname: Xu
authors.affiliation: School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, China.|Institute of Moléculaires Sciences d'Orsay, UMR CNRS 8214, Université Paris Sud, Université Paris-Saclay, 91400, Orsay, France.
authors.forename: Xue
authors.initials: X
authors.lastname: Li
authors.affiliation: School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, China. chendawei@syphu.edu.cn.
authors.forename: Dawei
authors.initials: D
authors.lastname: Chen
authors.affiliation: Institute of Moléculaires Sciences d'Orsay, UMR CNRS 8214, Université Paris Sud, Université Paris-Saclay, 91400, Orsay, France. ruxandra.gref@u-psud.fr.
authors.forename: Ruxandra
authors.initials: R
authors.lastname: Gref
authors.affiliation: School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, China. jwzhang@simm.ac.cn.|Center for Drug Delivery System, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, No. 501 of Haike Road, Shanghai, 201210, China. jwzhang@simm.ac.cn.
authors.forename: Jiwen
authors.initials: J
authors.lastname: Zhang
mesh_terms: D019342:Acetic Acid / Q000737:chemistry; D002152:Calorimetry, Differential Scanning / Q000379:methods; D000073396:Metal-Organic Frameworks / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning / Q000379:methods; D062105:Molecular Docking Simulation / Q000379:methods; D053758:Nanoparticles / Q000737:chemistry; D009930:Organic Chemicals / Q000737:chemistry*; D010316:Particle Size; D011208:Powders / Q000737:chemistry; D013395:Sucrose / Q000031:analogs & derivatives* / Q000737:chemistry; D013818:Thermogravimetry; D014961:X-Ray Diffraction / Q000379:methods; D047408:gamma-Cyclodextrins / Q000737:chemistry*
chemical_list: D000073396:Metal-Organic Frameworks; D009930:Organic Chemicals; D011208:Powders; D047408:gamma-Cyclodextrins; D013395:Sucrose; C026285:trichlorosucrose; C023792:gamma-cyclodextrin; D019342:Acetic Acid
keywords: cyclodextrin metal-organic frameworks; sucralose; thermal stability