title: Chronic Lymphocytic Leukemia with Translocation (2;14)(p16;q32): A Case Report and Review of the Literature.
abstract: We report the case of a young African American male with no significant past medical history presenting with low back and bilateral leg pain; presenting CBC and chemistries revealed elevated white blood cell count of 250,000, with anemia (Hb 6.8 g/dL) and thrombocytopenia (platelets 9 K/μL), and elevated LDH, 1008. Physical examination findings were notable for diffuse lymphadenopathy and lower extremity skin nodules. Interestingly the bone marrow biopsy revealed involvement by CLL/SLL with translocation (2;14)(p16;q32) and trisomy 12. The patient was treated with fludarabine-based chemotherapy and steroids for CLL-related ITP with excellent response. After three cycles of chemotherapy, all the enlarged lymph nodes and skin nodules disappeared, and patient had achieved complete hematologic response. In this paper we also reviewed the available literature of CLL patients with translocation (2;14).
authors.affiliation: Department of Medicine, Division of Hematology Oncology, University of Arkansas for Medical Science, Little Rock, AR, USA.
authors.forename: Francisco
authors.identifier: 0000-0003-0362-6845
authors.initials: F
authors.lastname: Socola
authors.affiliation: Department of Hematopathology/Molecular Genetics Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Insuasti-Beltran
authors.affiliation: Department of Hematopathology/Molecular Genetics Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Henrich Lobo
authors.affiliation: Department of Medicine, Division of Hematology Oncology, University of Arkansas for Medical Science, Little Rock, AR, USA.
authors.forename: Shebli
authors.initials: S
authors.lastname: Atrash
authors.affiliation: Department of Medicine, Division of Hematology Oncology, University of Arkansas for Medical Science, Little Rock, AR, USA.
authors.forename: Appalanaidu
authors.initials: A
authors.lastname: Sasapu