title: Optimal Fluid Therapy for Traumatic Hemorrhagic Shock.
abstract: The resuscitation of traumatic hemorrhagic shock has undergone a paradigm shift in the last 20 years with the advent of damage control resuscitation (DCR). Major principles of DCR include minimization of crystalloid, permissive hypotension, transfusion of a balanced ratio of blood products, and goal-directed correction of coagulopathy. In particular, plasma has replaced crystalloid as the primary means for volume expansion for traumatic hemorrhagic shock. Predicting which patient will require DCR by prompt and accurate activation of a massive transfusion protocol, however, remains a challenge.
authors.affiliation: Center for Translational Injury Research, University of Texas Health Science Center, 6410 Fannin Street, Suite 1100, Houston, TX 77030, USA. Electronic address: ronald.chang@uth.tmc.edu.
authors.forename: Ronald
authors.initials: R
authors.lastname: Chang
authors.affiliation: Department of Surgery, University of Texas Health Science Center, 6410 Fannin Street, Suite 1100, Houston, TX 77030, USA.
authors.forename: John B
authors.initials: JB
authors.lastname: Holcomb
mesh_terms: D001803:Blood Transfusion / Q000592:standards*; D005440:Fluid Therapy / Q000592:standards*; D006801:Humans; D007552:Isotonic Solutions / Q000627:therapeutic use*; D017410:Practice Guidelines as Topic; D012151:Resuscitation / Q000592:standards*; D012771:Shock, Hemorrhagic / Q000175:diagnosis* / Q000628:therapy*
chemical_list: D007552:Isotonic Solutions
keywords: Damage control resuscitation; Hemorrhagic shock; Massive transfusion protocol