title: A indicator of visceral adipose dysfunction to evaluate metabolic health in adult Chinese.
abstract: Visceral adipose dysfunction is a major cause of metabolic disorders. However, there is lack of a clinical index for prediction of visceral fat dysfunction in Asians. The present study aims to establish a visceral adiposity index for evaluation of metabolic health status in Chinese, the largest Asian ethnic group. 485 subjects were recruited from Lianqian Community, Xiamen and received abdominal computed tomography(CT) for visceral fat area. A Chinese visceral adiposity index (CVAI) was created using multivariate linear regression analyses, and was further validated in 6495 subjects recruited from Changfeng Community, Shanghai. CVAI was well associated with visceral obesity (r = 0.68, P < 0.001) and HOMA-IR (r = 0.60, P < 0.001). The AUROCs were 0.89(0.88-0.90), 0.72(0.71-0.73), 0.69(0.68-0.71) and 0.67(0.65-0.68) for determination of metabolic syndrome, hypertension, diabetes and prediabetes, respectively. CVAI was more valuable compared to BMI and waist circumference in evaluation of metabolic risks (all P < 0.001), even in subjects with metabolically unhealthy normal weight (MUNW) and metabolically healthy obese/overweight (MHO). This study demonstrates that CVAI is a reliable and applicable index for evaluation of visceral fat dysfunction in Chinese. It might be used to evaluate metabolic health status in Asians.
authors.affiliation: Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, China.|Institute of Chronic Metabolic Diseases, Fudan Unversity, Shanghai, China.
authors.forename: Ming-Feng
authors.initials: MF
authors.lastname: Xia
authors.affiliation: Department of Endocrinology and Metabolism, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, China.|Institute of Chronic Metabolic Diseases, Fudan Unversity, Shanghai, China.
authors.forename: Huan-Dong
authors.initials: HD
authors.lastname: Lin
authors.affiliation: Department of Geriatrics, Zhongshan Hospital, Fudan University, Shanghai, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Ma
authors.affiliation: Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, China.|Institute of Chronic Metabolic Diseases, Fudan Unversity, Shanghai, China.
authors.forename: Xiao-Ming
authors.initials: XM
authors.lastname: Li
authors.affiliation: Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, China.|Institute of Chronic Metabolic Diseases, Fudan Unversity, Shanghai, China.
authors.forename: Qiqige
authors.initials: Q
authors.lastname: Aleteng
authors.affiliation: Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, China.|Institute of Chronic Metabolic Diseases, Fudan Unversity, Shanghai, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Li
authors.affiliation: Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, China.|Institute of Chronic Metabolic Diseases, Fudan Unversity, Shanghai, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Wang
authors.affiliation: Department of Geriatrics, Zhongshan Hospital, Fudan University, Shanghai, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Hu
authors.affiliation: Department of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
authors.forename: Bai-Shen
authors.initials: BS
authors.lastname: Pan
authors.affiliation: Xiamen Diabetes Institute, Department of Endocrinology and Metabolism, The First Hospital of Xiamen, Xiamen University, 55 Zhenhai Road, Xiamen 361003, China.
authors.forename: Xue-Jun
authors.initials: XJ
authors.lastname: Li
authors.affiliation: Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, China.|Institute of Chronic Metabolic Diseases, Fudan Unversity, Shanghai, China.
authors.forename: Xiao-Ying
authors.initials: XY
authors.lastname: Li
authors.affiliation: Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, China.|Institute of Chronic Metabolic Diseases, Fudan Unversity, Shanghai, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Gao
mesh_terms: D050154:Adiposity; D000328:Adult; D044466:Asian People; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D050152:Intra-Abdominal Fat / Q000000981:diagnostic imaging*; D008297:Male; D024821:Metabolic Syndrome / Q000000981:diagnostic imaging* / Q000453:epidemiology; D008875:Middle Aged; D014057:Tomography, X-Ray Computed