title: On the Mechanics of Transcatheter Aortic Valve Replacement.
abstract: Transcatheter aortic valves (TAVs) represent the latest advances in prosthetic heart valve technology. TAVs are truly transformational as they bring the benefit of heart valve replacement to patients that would otherwise not be operated on. Nevertheless, like any new device technology, the high expectations are dampened with growing concerns arising from frequent complications that develop in patients, indicating that the technology is far from being mature. Some of the most common complications that plague current TAV devices include malpositioning, crimp-induced leaflet damage, paravalvular leak, thrombosis, conduction abnormalities and prosthesis-patient mismatch. In this article, we provide an in-depth review of the current state-of-the-art pertaining the mechanics of TAVs while highlighting various studies guiding clinicians, regulatory agencies, and next-generation device designers.
authors.affiliation: Department of Biomedical Engineering, Dorothy Davis Heart and Lung Research Institute, The Ohio State University, 473 W 12th Avenue, Columbus, OH, 43210, USA. dasi.1@osu.edu.
authors.forename: Lakshmi P
authors.initials: LP
authors.lastname: Dasi
authors.affiliation: Department of Biomedical Engineering, Dorothy Davis Heart and Lung Research Institute, The Ohio State University, 473 W 12th Avenue, Columbus, OH, 43210, USA.
authors.forename: Hoda
authors.initials: H
authors.lastname: Hatoum
authors.affiliation: The Edwards Lifesciences Center for Advanced Cardiovascular Technology, Department of Biomedical Engineering, University of California, Irvine, CA, 92697, USA.
authors.forename: Arash
authors.initials: A
authors.lastname: Kheradvar
authors.affiliation: The Edwards Lifesciences Center for Advanced Cardiovascular Technology, Department of Biomedical Engineering, University of California, Irvine, CA, 92697, USA.
authors.forename: Ramin
authors.initials: R
authors.lastname: Zareian
authors.affiliation: The Edwards Lifesciences Center for Advanced Cardiovascular Technology, Department of Biomedical Engineering, University of California, Irvine, CA, 92697, USA.
authors.forename: S Hamed
authors.initials: SH
authors.lastname: Alavi
authors.affiliation: Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, 30332, USA.
authors.forename: Wei
authors.initials: W
authors.lastname: Sun
authors.affiliation: Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, 30332, USA.
authors.forename: Caitlin
authors.initials: C
authors.lastname: Martin
authors.affiliation: Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, 30332, USA.
authors.forename: Thuy
authors.initials: T
authors.lastname: Pham
authors.affiliation: Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, 30332, USA.
authors.forename: Qian
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, 30332, USA.
authors.forename: Prem A
authors.initials: PA
authors.lastname: Midha
authors.affiliation: Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, 30332, USA.
authors.forename: Vrishank
authors.initials: V
authors.lastname: Raghav
authors.affiliation: Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, 30332, USA.
authors.forename: Ajit P
authors.initials: AP
authors.lastname: Yoganathan
mesh_terms: D000818:Animals; D006350:Heart Valve Prosthesis; D006801:Humans; D011474:Prosthesis Design / Q000379:methods*; D065467:Transcatheter Aortic Valve Replacement / Q000009:adverse effects / Q000295:instrumentation* / Q000379:methods*
keywords: Minimally invasive; Paravalvular leak; Stent; TAVR; Thrombosis; Transcatheter aortic valve; Valve-in-valve