title: Science Signaling Podcast for 15 November 2016: A new type of kinase inhibitor.
abstract: This Podcast features an interview with Hagit Eldar-Finkelman, author of a Research Article that appears in the 15 November 2016 issue of Science Signaling, about a newly developed inhibitor of glycogen synthase kinase 3 (GSK-3). GSK-3 participates in several signaling networks and has been implicated in various pathologies, including neurodegenerative diseases, cognitive impairments, and cancer. Licht-Murava et al developed L807mts, a substrate-competitive peptide inhibitor that blocks GSK-3 activity through an unusual mechanism. L807mts not only bound to the substrate recognition domain of GSK-3, it was also phosphorylated by the kinase. This phosphorylated form of L807mts remained associated with GSK-3 and inhibited GSK-3 activity. L807mts treatment reduced cellular, cognitive, and behavioral symptoms in a mouse model of Alzheimer's disease. L807mts is an advance in kinase inhibitor development because it is both highly specific and very potent.Listen to Podcast.
authors.affiliation: The Departments of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, 69978, Israel.
authors.forename: Hagit
authors.initials: H
authors.lastname: Eldar-Finkelman
authors.affiliation: Web Editor, Science Signaling, American Association for the Advancement of Science, 1200 New York Avenue, NW, Washington, DC 20005, USA.
authors.forename: Annalisa M
authors.initials: AM
authors.lastname: VanHook
mesh_terms: D000818:Animals; D060825:Cognitive Dysfunction / Q000188:drug therapy / Q000201:enzymology; D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D038362:Glycogen Synthase Kinase 3 / Q000037:antagonists & inhibitors*; D006801:Humans; D051379:Mice; D009369:Neoplasms / Q000188:drug therapy / Q000201:enzymology; D019636:Neurodegenerative Diseases / Q000188:drug therapy / Q000201:enzymology; D010455:Peptides / Q000627:therapeutic use*
chemical_list: D004791:Enzyme Inhibitors; D010455:Peptides; D038362:Glycogen Synthase Kinase 3