title: SEOM Clinical Guideline for gastrointestinal sarcomas (GIST) (2016).
abstract: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the digestive tract, and this disease has served as a paradigmatic model for successful rational development of targeted therapies. The introduction of tyrosine kinase inhibitors with activity against KIT/PDGFRA in both localized and advanced stages has remarkably improved the survival in a disease formerly deemed resistant to all systemic therapies. The Spanish Society of Medical Oncology (SEOM) guidelines provide a multidisciplinary and updated consensus for the diagnosis and treatment of GIST patients. We strongly encourage that the managing of these patients should be performed within multidisciplinary teams in reference centers.
authors.affiliation: Department of Medical Oncology, Instituto Valenciano de Oncología, IVO, Valencia, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Poveda
authors.affiliation: Department of Medical Oncology, Hospital Universitario La Paz, Madrid, Spain.
authors.forename: V
authors.initials: V
authors.lastname: Martinez
authors.affiliation: Department of Medical Oncology, Vall d'Hebron Institute of Oncology, Hospital Universitario Vall d'Hebron, Barcelona, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Serrano
authors.affiliation: Investigación Clínica y Traslacional en Cáncer, Instituto de Investigaciones Biomédicas de Málaga (IBIMA), Hospitales Universitarios Regional y Virgen de la Victoria de Málaga, Málaga, Spain.
authors.forename: I
authors.initials: I
authors.lastname: Sevilla
authors.affiliation: Department of Medical Oncology, Complejo Hospitalario de Navarra, Navarre, Spain.
authors.forename: M J
authors.initials: MJ
authors.lastname: Lecumberri
authors.affiliation: Musculoskeletal and Gastric Tumor Unit, Department of Medical Oncology, Hospital Universitario y Politécnico La Fe, Valencia, Spain.
authors.forename: R D
authors.initials: RD
authors.lastname: de Beveridge
authors.affiliation: Department of Medical Oncology, Instituto Catalán de Oncología, ICO-Badalona, Hospital Germans Trias i Pujol, Badalona, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Estival
authors.affiliation: Department of Medical Oncology, Hospital Universitario Virgen Macarena, Badalona, Spain.
authors.forename: D
authors.initials: D
authors.lastname: Vicente
authors.affiliation: Department of Medical Oncology, Instituto Catalán de Oncología, ICO-Girona, Hospital Josep Trueta, Girona, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Rubió
authors.affiliation: Department of Medical Oncology and Insituto de Biomedicina, IBIS, Hospital Universitario Virgen del Rocio, Av. Manuel Siurot, s/n, 41013, Sevilla, Spain. jmartin@mustbesevilla.org.
authors.forename: J
authors.initials: J
authors.lastname: Martin-Broto
mesh_terms: D005770:Gastrointestinal Neoplasms / Q000175:diagnosis* / Q000628:therapy*; D046152:Gastrointestinal Stromal Tumors / Q000175:diagnosis* / Q000628:therapy*; D006801:Humans; D017410:Practice Guidelines as Topic; D013030:Spain
keywords: GIST; Imatinib; Regorafenib; Sunitinib