title: [Morbidity profile among adolescents with Down syndrome].
abstract: BACKGROUND
  There is a paucity of information about morbidity and mortality of adolescents with Down syndrome (DS).
  
  
  OBJECTIVE
  To describe morbidity and mortality of a cohort of Chilean adolescents with DS.
  
  
  METHODS
  Review of electronic clinical records of 67 ambulatory patients with DS aged 10 to 20 years (37 women), seen between the years 2007 and 2014 in outpatient clinics of a University hospital.
  
  
  RESULTS
  The mean age at the last consultation was 13 ± 3 years. Ninety-eight percent of patients had a chronic condition: 37.1% where overweight or obese, 58.2% had a congenital heart disease, 11.9% where being evaluated or had the diagnosis of autism and 44.8% had hypothyroidism. Pubertal development was consistent with chronologic age in 93.7% of patients. In three patients puberty had been suppressed. In women, average age of menarche was 12.2 ± 1.1 years. There were no deaths reported.
  
  
  CONCLUSIONS
  There was a high rate of comorbidities in this group of adolescents with DS, most of them with frequencies comparable to those reported in literature.
authors.forename: Antonia
authors.initials: A
authors.lastname: Cárdenas
authors.forename: María A
authors.initials: MA
authors.lastname: Paul
authors.forename: Catalina
authors.initials: C
authors.lastname: Correa
authors.forename: Sebastián
authors.initials: S
authors.lastname: Valderrama
authors.forename: Jaime
authors.initials: J
authors.lastname: Cerda
authors.forename: Macarena
authors.initials: M
authors.lastname: Lizama
mesh_terms: D000293:Adolescent; D001321:Autistic Disorder / Q000453:epidemiology; D002648:Child; D002677:Chile / Q000453:epidemiology; D002908:Chronic Disease; D004314:Down Syndrome / Q000453:epidemiology*; D005260:Female; D006330:Heart Defects, Congenital / Q000453:epidemiology; D006801:Humans; D007037:Hypothyroidism / Q000453:epidemiology; D008297:Male; D009017:Morbidity; D050177:Overweight / Q000453:epidemiology; D015995:Prevalence; D012189:Retrospective Studies; D055815:Young Adult