title: Circadian fluctuations in circulating plasminogen activator inhibitor-1 are independent of feeding cycles in mice.
abstract: To evaluate the involvement of the day-night feeding cycle in the circadian regulation of circulating plasminogen activator inhibitor-1 (PAI-1) concentrations, mice were fed with a diet for eight hours during either daytime (DF) or nighttime (NF) for one week. The reversed feeding cycle did not affect the circadian phases of plasma PAI-1 levels as well as the nocturnal wheel-running activity, although the phase of Pai-1 mRNA expression was significantly advanced for 8.6 hours in the livers of DF, compared with NF mice. The day-night feeding cycle is not a critical Zeitgeber for circadian rhythm of circulating PAI-1.
authors.affiliation: a Biological Clock Research Group, Biomedical Research Institute , National Institute of Advanced Industrial Science and Technology (AIST) , Tsukuba , Ibaraki , Japan.|b Department of Applied Biological Science, Graduate School of Science and Technology , Tokyo University of Science , Noda , Chiba , Japan.|c Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences , University of Tokyo , Kashiwa , Chiba , Japan.
authors.forename: Katsutaka
authors.initials: K
authors.lastname: Oishi
authors.affiliation: d Molecular Physiology and Pathology , School of Pharma-Sciences, Teikyo University , Itabashi , Tokyo , Japan.
authors.forename: Naoki
authors.initials: N
authors.lastname: Ohkura
authors.affiliation: a Biological Clock Research Group, Biomedical Research Institute , National Institute of Advanced Industrial Science and Technology (AIST) , Tsukuba , Ibaraki , Japan.|b Department of Applied Biological Science, Graduate School of Science and Technology , Tokyo University of Science , Noda , Chiba , Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Yasumoto
authors.affiliation: a Biological Clock Research Group, Biomedical Research Institute , National Institute of Advanced Industrial Science and Technology (AIST) , Tsukuba , Ibaraki , Japan.
authors.forename: Saori
authors.initials: S
authors.lastname: Yamamoto
mesh_terms: D000818:Animals; D002940:Circadian Rhythm; D005247:Feeding Behavior; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D012333:RNA, Messenger / Q000378:metabolism; D058258:Serpin E2 / Q000097:blood* / Q000235:genetics; D013997:Time Factors
chemical_list: D012333:RNA, Messenger; D058258:Serpin E2; C511869:Serpine2 protein, mouse
keywords: Circadian clocks; circadian rhythm; feeding behavior; fibrinolysis; mouse; plasminogen activator inhibitor-1