title: Future Prospects for Scaffolding Methods and Biomaterials in Skin Tissue Engineering: A Review.
abstract: Over centuries, the field of regenerative skin tissue engineering has had several advancements to facilitate faster wound healing and thereby restoration of skin. Skin tissue regeneration is mainly based on the use of suitable scaffold matrices. There are several scaffold types, such as porous, fibrous, microsphere, hydrogel, composite and acellular, etc., with discrete advantages and disadvantages. These scaffolds are either made up of highly biocompatible natural biomaterials, such as collagen, chitosan, etc., or synthetic materials, such as polycaprolactone (PCL), and poly-ethylene-glycol (PEG), etc. Composite scaffolds, which are a combination of natural or synthetic biomaterials, are highly biocompatible with improved tensile strength for effective skin tissue regeneration. Appropriate knowledge of the properties, advantages and disadvantages of various biomaterials and scaffolds will accelerate the production of suitable scaffolds for skin tissue regeneration applications. At the same time, emphasis on some of the leading challenges in the field of skin tissue engineering, such as cell interaction with scaffolds, faster cellular proliferation/differentiation, and vascularization of engineered tissues, is inevitable. In this review, we discuss various types of scaffolding approaches and biomaterials used in the field of skin tissue engineering and more importantly their future prospects in skin tissue regeneration efforts.
authors.affiliation: Center for Nanobiotechnology Research, Alabama State University, Montgomery, AL 36104, USA. atulvet@gmail.com.
authors.forename: Atul A
authors.initials: AA
authors.lastname: Chaudhari
authors.affiliation: Center for Nanobiotechnology Research, Alabama State University, Montgomery, AL 36104, USA. komalvig@alasu.edu.
authors.forename: Komal
authors.initials: K
authors.lastname: Vig
authors.affiliation: Center for Nanobiotechnology Research, Alabama State University, Montgomery, AL 36104, USA. drbaganizi@gmail.com.
authors.forename: Dieudonné Radé
authors.initials: DR
authors.lastname: Baganizi
authors.affiliation: Center for Nanobiotechnology Research, Alabama State University, Montgomery, AL 36104, USA. sahu.rajnish@gmail.com.
authors.forename: Rajnish
authors.initials: R
authors.lastname: Sahu
authors.affiliation: Center for Nanobiotechnology Research, Alabama State University, Montgomery, AL 36104, USA. sdixit@alasu.edu.
authors.forename: Saurabh
authors.initials: S
authors.lastname: Dixit
authors.affiliation: Center for Nanobiotechnology Research, Alabama State University, Montgomery, AL 36104, USA. vdennis@alasu.edu.
authors.forename: Vida
authors.initials: V
authors.lastname: Dennis
authors.affiliation: Center for Nanobiotechnology Research, Alabama State University, Montgomery, AL 36104, USA. ssingh@alasu.edu.
authors.forename: Shree Ram
authors.initials: SR
authors.lastname: Singh
authors.affiliation: Center for Nanobiotechnology Research, Alabama State University, Montgomery, AL 36104, USA. spillai@alasu.edu.
authors.forename: Shreekumar R
authors.initials: SR
authors.lastname: Pillai
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry; D012867:Skin; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds / Q000737:chemistry; D014945:Wound Healing / Q000502:physiology
chemical_list: D001672:Biocompatible Materials; D011108:Polymers
keywords: biomaterials; natural; polymer; scaffolds; skin; synthetic; tissue engineering; wound healing