title: Central hemodynamics and arterial stiffness in idiopathic and multiple system atrophy.
abstract: Blood pressure is commonly abnormal in parkinsonian disorders, but central hemodynamics and arterial stiffness, well-established predictors of total cardiovascular risk, have rarely been studied in these disorders. 32 patients [27 with idiopathic Parkinson's disease (iPD); 5 with multiple system atrophy (MSA)] and 15 controls matched for cardiac risk factors underwent 24 h-ambulatory blood pressure recordings using an I.E.M. device (Mobil-O-Graph™), measuring peripheral pressure and calculating central pressures and arterial stiffness. Mean augmentation indices corrected for heart rate (AIx@75) were significantly lower and pulse wave velocities were significantly elevated in patients compared to controls. Central systolic blood pressure, cardiac output and daytime total vascular resistance were significantly elevated in patients. Mean nocturnal systolic peripheral blood pressure and nocturnal heart rates were also significantly higher; 56.3% of patients had nocturnal hypertension (80% of the MSA group); 85.2% showed non-dipping. This supports previous findings of reduced vulnerability to systemic atherosclerosis and end-organ damage in treated PD. Yet, hemodynamic abnormalities were common and often remained asymptomatic.
authors.affiliation: Department of Pneumology, University Hospital Lübeck, Lübeck, Germany.
authors.forename: Klaas
authors.initials: K
authors.lastname: Franzen
authors.affiliation: Department of Neurology, Christian-Albrechts-University Kiel, Kiel, Germany.
authors.forename: Sabine
authors.initials: S
authors.lastname: Fliegen
authors.affiliation: Department of Cardiology, University Hospital Lübeck, Lübeck, Germany.
authors.forename: Jelena
authors.initials: J
authors.lastname: Koester
authors.affiliation: Department of Comparative Development and Genetics, Max Planck Institute for Plant Breeding Research, Cologne, Germany.
authors.forename: Rafael Campos
authors.initials: RC
authors.lastname: Martin
authors.affiliation: Department of Neurology, Christian-Albrechts-University Kiel, Kiel, Germany.
authors.forename: Günther
authors.initials: G
authors.lastname: Deuschl
authors.affiliation: Department of Cardiology, University Hospital Lübeck, Lübeck, Germany.|Medical Practice for Cardiology and Angiology Landsberg, Landsberg am Lech, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Reppel
authors.affiliation: Department of Cardiology, University Hospital Lübeck, Lübeck, Germany.|Cardiology Practice Kiel, Kiel, Germany.
authors.forename: Kai
authors.initials: K
authors.lastname: Mortensen
authors.affiliation: Department of Neurology, Christian-Albrechts-University Kiel, Kiel, Germany. susanne.schneider@med.uni-muenchen.de.|Department of Neurology, Ludwig-Maximilians-University München, Feodor-Lynen-Straße 19, 81377, Munich, Germany. susanne.schneider@med.uni-muenchen.de.
authors.forename: Susanne A
authors.initials: SA
authors.lastname: Schneider
mesh_terms: D000368:Aged; D018660:Blood Pressure Monitoring, Ambulatory; D002318:Cardiovascular Diseases / Q000188:drug therapy / Q000453:epidemiology / Q000503:physiopathology; D002940:Circadian Rhythm / Q000502:physiology; D015331:Cohort Studies; D005260:Female; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D019578:Multiple System Atrophy / Q000188:drug therapy / Q000503:physiopathology*; D010300:Parkinson Disease / Q000188:drug therapy / Q000503:physiopathology*; D012307:Risk Factors; D059289:Vascular Stiffness / Q000502:physiology
keywords: Arterial stiffness; Atypical parkinsonism; Blood pressure; Central hemodynamics; Multiple system atrophy; Parkinson’s disease