title: [Prognostic biochemical markers of thrombolytic therapy in ischemic stroke].
abstract: OBJECTIVE
  To assess prognostic value of endothelial dysfunction, endogenous intoxication and oxidative stress in the acute period of ischemic stroke (II) at the stage of making a decision on using thrombolytic therapy (TLT) as well during the follow-up in order to personalize treatment.
  
  
  METHODS
  The study included 57 patients stratified into control group 1 (n=29) and TLT group (n=28). Contents of C-reactive protein (Nsrb), matrixmetalloproteinase-9 (MMP-9) erythrocyte lipid peroxidation products were measured in the blood of patients. Clinical outcomes were evaluated with the modified Rankin scale and the Rivermead Mobility Index.
  
  
  RESULTS
  Increased levels of Nsrb and MMP-9 were the biomarkers of poor TLT outcome.
  
  
  CONCLUSIONS
  TLT has a positive effect on the basic patterns of IS pathogenesis and biochemical predictors allow to rationalize the treatment.
authors.affiliation: Tyumen State Medical Academy Ministry University, Tyumen, Russia.
authors.forename: O A
authors.initials: OA
authors.lastname: Kicherova
authors.affiliation: Tyumen State Medical Academy Ministry University, Tyumen, Russia.
authors.forename: L I
authors.initials: LI
authors.lastname: Reikhert
authors.affiliation: Tyumen State Medical Academy Ministry University, Tyumen, Russia.
authors.forename: V G
authors.initials: VG
authors.lastname: Skorikova
authors.affiliation: Tyumen State Medical Academy Ministry University, Tyumen, Russia.
authors.forename: S A
authors.initials: SA
authors.lastname: Semeshko
mesh_terms: D015415:Biomarkers / Q000097:blood*; D002545:Brain Ischemia / Q000175:diagnosis / Q000188:drug therapy*; D002097:C-Reactive Protein; D006801:Humans; D015227:Lipid Peroxidation; D018384:Oxidative Stress; D011379:Prognosis; D020521:Stroke / Q000175:diagnosis / Q000188:drug therapy*; D015912:Thrombolytic Therapy
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein