title: [Contribution and challenges of Big Data in oncology].
abstract: Since the first draft of the human genome sequence published in 2001, the cost of sequencing has dramatically decreased. The development of new technologies such as next generation sequencing led to a comprehensive characterization of a large number of tumors of various types as well as to significant advances in precision medicine. Despite the valuable information this technological revolution has allowed to produce, the vast amount of data generated resulted in the emergence of new challenges for the biomedical community, such as data storage, processing and mining. Here, we describe the contribution and challenges of Big Data in oncology.
authors.affiliation: Université Lyon, université Claude-Bernard Lyon 1, centre Léon-Bérard, centre de recherche en cancérologie de Lyon, CNRS 5286, Inserm 1052, 69008 Lyon, France; Centre Léon-Bérard, département de médecine et département de recherche translationnelle et de l'innovation, 28, rue Laënnec, 28, rue Laennec, 69373 Lyon cedex 08, France. Electronic address: pierre.saintigny@lyon.unicancer.fr.
authors.forename: Pierre
authors.initials: P
authors.lastname: Saintigny
authors.affiliation: Université Lyon, université Claude-Bernard Lyon 1, centre Léon-Bérard, centre de recherche en cancérologie de Lyon, CNRS 5286, Inserm 1052, 69008 Lyon, France; Université Pierre-et-Marie-Curie, Paris 6, hôpital Pitié-Salpêtrière, service de chirurgie maxillo-faciale, groupe hospitalier Pitié-Salpêtrière, 47-83, boulevard de l'Hôpital, 75013 Paris cedex 13, France.
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Foy
authors.affiliation: Plateforme de bio-informatique-Gilles-Thomas, synergie Lyon Cancer, 69008 Lyon, France.
authors.forename: Anthony
authors.initials: A
authors.lastname: Ferrari
authors.affiliation: Centre Léon-Bérard, département de médecine et département de recherche translationnelle et de l'innovation, 28, rue Laënnec, 28, rue Laennec, 69373 Lyon cedex 08, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Cassier
authors.affiliation: Plateforme de bio-informatique-Gilles-Thomas, synergie Lyon Cancer, 69008 Lyon, France; INRIA Grenoble-Rhône-Alpes, 655, avenue de l'Europe, 38330 Montbonnot-Saint-Martin, France.
authors.forename: Alain
authors.initials: A
authors.lastname: Viari
authors.affiliation: Université Lyon, université Claude-Bernard Lyon 1, centre Léon-Bérard, centre de recherche en cancérologie de Lyon, CNRS 5286, Inserm 1052, 69008 Lyon, France.
authors.forename: Alain
authors.initials: A
authors.lastname: Puisieux
mesh_terms: D022126:Access to Information; D057225:Data Mining; D001330:Electronic Data Processing; D005260:Female; D015894:Genome, Human; D023281:Genomics; D006801:Humans; D016247:Information Storage and Retrieval; D008297:Male; D008495:Medical Oncology; D009369:Neoplasms / Q000145:classification / Q000235:genetics*; D017422:Sequence Analysis, DNA
keywords: Big Data; Cancérologie; Classification moléculaire; Heterogeneity; Hétérogénéité; Molecular classification; Médecine de précision; Oncology; Precision medicine