title: NSDNA: a manually curated database of experimentally supported ncRNAs associated with nervous system diseases.
abstract: The Nervous System Disease NcRNAome Atlas (NSDNA) (http://www.bio-bigdata.net/nsdna/) is a manually curated database that provides comprehensive experimentally supported associations about nervous system diseases (NSDs) and noncoding RNAs (ncRNAs). NSDs represent a common group of disorders, some of which are characterized by high morbidity and disabilities. The pathogenesis of NSDs at the molecular level remains poorly understood. ncRNAs are a large family of functionally important RNA molecules. Increasing evidence shows that diverse ncRNAs play a critical role in various NSDs. Mining and summarizing NSD-ncRNA association data can help researchers discover useful information. Hence, we developed an NSDNA database that documents 24 713 associations between 142 NSDs and 8593 ncRNAs in 11 species, curated from more than 1300 articles. This database provides a user-friendly interface for browsing and searching and allows for data downloading flexibility. In addition, NSDNA offers a submission page for researchers to submit novel NSD-ncRNA associations. It represents an extremely useful and valuable resource for researchers who seek to understand the functions and molecular mechanisms of ncRNA involved in NSDs.
authors.affiliation: Department of Neurology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China.
authors.forename: Jianjian
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Neurology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China.
authors.forename: Yuze
authors.initials: Y
authors.lastname: Cao
authors.affiliation: Department of Neurology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China.
authors.forename: Huixue
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Neurology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China.
authors.forename: Tianfeng
authors.initials: T
authors.lastname: Wang
authors.affiliation: Department of Neurology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China.
authors.forename: Qinghua
authors.initials: Q
authors.lastname: Tian
authors.affiliation: Department of Neurology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China.
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Lu
authors.affiliation: Department of Neurology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China.
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Lu
authors.affiliation: Department of Neurology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China.
authors.forename: Xiaotong
authors.initials: X
authors.lastname: Kong
authors.affiliation: Department of Neurology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China.
authors.forename: Zhaojun
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Department of Neurology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Wang
authors.affiliation: Department of Neurology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China.
authors.forename: Shuai
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Department of Physiology, Emory University School of Medicine, Atlanta, GA 30322, USA heping.ma@emory.edu.
authors.forename: Heping
authors.initials: H
authors.lastname: Ma
authors.affiliation: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China ningsw@ems.hrbmu.edu.cn.
authors.forename: Shangwei
authors.initials: S
authors.lastname: Ning
authors.affiliation: Department of Neurology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China wanglh211@163.com.
authors.forename: Lihua
authors.initials: L
authors.lastname: Wang
mesh_terms: D030561:Databases, Nucleic Acid; D056726:Genetic Association Studies / Q000379:methods; D020022:Genetic Predisposition to Disease; D006801:Humans; D009422:Nervous System Diseases / Q000235:genetics*; D022661:RNA, Untranslated; D014584:User-Computer Interface; D064878:Web Browser
chemical_list: D022661:RNA, Untranslated