title: Probes for manipulating and monitoring IP3.
abstract: Inositol 1,4,5-trisphosphate (IP3) is an important second messenger produced via G-protein-coupled receptor- or receptor tyrosine kinase-mediated pathways. IP3levels induce Ca2+release from the endoplasmic reticulum (ER) via IP3receptor (IP3R) located in the ER membrane. The resultant spatiotemporal pattern of Ca2+signals regulates diverse cellular functions, including fertilization, gene expression, synaptic plasticity, and cell death. Therefore, monitoring and manipulating IP3levels is important to elucidate not only the functions of IP3-mediated pathways but also the encoding mechanism of IP3R as a converter of intracellular signals from IP3to Ca2+.
authors.affiliation: Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
authors.forename: Akitoshi
authors.initials: A
authors.lastname: Miyamoto
authors.affiliation: Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan. Electronic address: mikosiba@brain.riken.jp.
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Mikoshiba
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism; D005456:Fluorescent Dyes / Q000378:metabolism; D006801:Humans; D015544:Inositol 1,4,5-Trisphosphate / Q000378:metabolism*; D015335:Molecular Probes / Q000378:metabolism*; D062308:Optogenetics; D015398:Signal Transduction
chemical_list: D005456:Fluorescent Dyes; D015335:Molecular Probes; D015544:Inositol 1,4,5-Trisphosphate; D002118:Calcium
keywords: IP(3) induced Ca(2+) response; IP(3) probes