title: Effects of aluminum trichloride on the cartilage stimulatory growth factors in rats.
abstract: Aluminum (Al) is considered to be a potentially toxic metal and inhibits cartilage formation. Transforming growth factor β1 (TGF-β1) and bone morphogenetic protein 2 (BMP-2) are cartilage stimulatory growth factors, which play important roles in regulating the cartilage formation. To investigate the effects of aluminum trichloride (AlCl3) on the regulation of cartilage formation. Eighty Wistar rats were orally exposed to 0 (control group), 0.4 g/L (low-dose group), 0.8 g/L (mid-dose group) and 1.6 g/L (high-dose group) AlCl3for 120 days, respectively. The rats body weight were decreased, the cartilage histological structure were disrupted, the cartilage and serum contents of Al and the serum level of C-telopeptide of type II collagen were all increased, the serum level of type II collagen (Col II) and alkaline phosphatase (ALP), and the mRNA expressions of TGF-β1, BMP-2, ALP and Col II were all decreased in the AlCl3-treated groups compared with those in control group. These results indicate that AlCl3inhibits the cartilage formation through inhibition of the cartilage stimulatory growth factors expressions.
authors.affiliation: College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China.
authors.forename: Fan
authors.initials: F
authors.lastname: Zhang
authors.affiliation: College of Veterinary Medicine, Jilin University, 5333 Xi'an Road, Changchun, Jilin, 130062, China.
authors.forename: Xudong
authors.initials: X
authors.lastname: Sun
authors.affiliation: College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China.
authors.forename: Hongyan
authors.initials: H
authors.lastname: Yu
authors.affiliation: College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Yang
authors.affiliation: College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China.
authors.forename: Miao
authors.initials: M
authors.lastname: Song
authors.affiliation: College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China.
authors.forename: Yanfei
authors.initials: Y
authors.lastname: Han
authors.affiliation: College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China. liyanfei@neau.edu.cn.
authors.forename: Yanfei
authors.initials: Y
authors.lastname: Li
authors.affiliation: Institute of Special Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, Changchun, Jilin, 130112, China. zhuyanzhu@caas.cn.
authors.forename: Yanzhu
authors.initials: Y
authors.lastname: Zhu
mesh_terms: D000535:Aluminum / Q000097:blood; D000077410:Aluminum Chloride; D017607:Aluminum Compounds / Q000494:pharmacology; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D055396:Bone Morphogenetic Protein 2 / Q000235:genetics* / Q000378:metabolism; D002356:Cartilage / Q000187:drug effects / Q000254:growth & development* / Q000378:metabolism; D002712:Chlorides / Q000494:pharmacology; D024043:Collagen Type II / Q000097:blood; D005786:Gene Expression Regulation / Q000187:drug effects; D051381:Rats; D015398:Signal Transduction / Q000187:drug effects; D053773:Transforming Growth Factor beta1 / Q000235:genetics* / Q000378:metabolism
chemical_list: D017607:Aluminum Compounds; D055396:Bone Morphogenetic Protein 2; D002712:Chlorides; D024043:Collagen Type II; C508962:Tgfb1 protein, rat; D053773:Transforming Growth Factor beta1; D000077410:Aluminum Chloride; D000535:Aluminum
keywords: Aluminum trichloride; Cartilage; Cartilage stimulatory growth factors; Rat