title: Cerebrospinal fluid anti-Epstein-Barr virus specific oligoclonal IgM and IgG bands in patients with clinically isolated and Guillain-Barré syndrome.
abstract: Epstein-Barr virus (EBV) has been implicated in multiple sclerosis (MS) pathogenesis. We aimed to assess the frequency of EBV-specific IgG and IgM oligoclonal bands (OCB) in cerebrospinal fluid (CSF) of 50 patients with clinically isolated syndrome (CIS) and in 27 controls with Guillain-Barré syndrome (GBS). Furthermore, we assessed correlations between the presence of OCB and CIS patients' CSF, MRI, and clinical variables. There was no difference in the proportion of CIS and GB patients with positivity for anti-EBV-specific IgG/IgM OCB. There were no correlations between OCB and analyzed variables, nor were they predictive of a higher disability at 3 years.
authors.affiliation: Neurology Unit, Department of Neurosciences, Nuovo Ospedale Civile S. Agostino Estense, AUSL Modena, Via Pietro Giardini, 1355, 41126, Modena, Italy. diana.ferraro@unimore.it.|Department of Biomedical, Metabolic and Neurosciences, University of Modena and Reggio Emilia, Via Pietro Giardini, 1355, 41126, Modena, Italy. diana.ferraro@unimore.it.
authors.forename: Diana
authors.initials: D
authors.lastname: Ferraro
authors.affiliation: Neuroimmunology Laboratory, Department of Biomedical, Metabolic and Neurosciences, University of Modena and Reggio Emilia, Via Pietro Giardini, 1355, 41126, Modena, Italy.
authors.forename: Veronica
authors.initials: V
authors.lastname: Galli
authors.affiliation: Neurology Unit, Department of Neurosciences, Nuovo Ospedale Civile S. Agostino Estense, AUSL Modena, Via Pietro Giardini, 1355, 41126, Modena, Italy.|Department of Biomedical, Metabolic and Neurosciences, University of Modena and Reggio Emilia, Via Pietro Giardini, 1355, 41126, Modena, Italy.
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Simone
authors.affiliation: Neuroimmunology Laboratory, Department of Biomedical, Metabolic and Neurosciences, University of Modena and Reggio Emilia, Via Pietro Giardini, 1355, 41126, Modena, Italy.
authors.forename: Roberta
authors.initials: R
authors.lastname: Bedin
authors.affiliation: Neurology Unit, Department of Neurosciences, Nuovo Ospedale Civile S. Agostino Estense, AUSL Modena, Via Pietro Giardini, 1355, 41126, Modena, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Vitetta
authors.affiliation: Neurology Unit, Department of Neurosciences, Nuovo Ospedale Civile S. Agostino Estense, AUSL Modena, Via Pietro Giardini, 1355, 41126, Modena, Italy.
authors.forename: Elisa
authors.initials: E
authors.lastname: Merelli
authors.affiliation: Neurology Unit, Department of Neurosciences, Nuovo Ospedale Civile S. Agostino Estense, AUSL Modena, Via Pietro Giardini, 1355, 41126, Modena, Italy.|Department of Biomedical, Metabolic and Neurosciences, University of Modena and Reggio Emilia, Via Pietro Giardini, 1355, 41126, Modena, Italy.
authors.forename: Paolo Frigio
authors.initials: PF
authors.lastname: Nichelli
authors.affiliation: Neurology Unit, Department of Neurosciences, Nuovo Ospedale Civile S. Agostino Estense, AUSL Modena, Via Pietro Giardini, 1355, 41126, Modena, Italy.
authors.forename: Patrizia
authors.initials: P
authors.lastname: Sola
mesh_terms: D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000134:cerebrospinal fluid*; D020031:Epstein-Barr Virus Infections / Q000134:cerebrospinal fluid* / Q000000981:diagnostic imaging / Q000276:immunology / Q000821:virology; D005260:Female; D020275:Guillain-Barre Syndrome / Q000134:cerebrospinal fluid* / Q000000981:diagnostic imaging / Q000276:immunology / Q000821:virology; D004854:Herpesvirus 4, Human / Q000254:growth & development / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000134:cerebrospinal fluid*; D007075:Immunoglobulin M / Q000134:cerebrospinal fluid*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D013577:Syndrome
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M
keywords: Clinically isolated syndrome; Epstein-Barr virus; Multiple sclerosis; Oligoclonal IgG bands; Oligoclonal IgM bands