title: TREX through Cutaneous Health and Disease.
abstract: TREX1 and 2 are exonucleases that repair and degrade DNA. Degradation of DNA is involved in maintaining the integrity of the epidermis. The importance of these enzymes to cutaneous integrity is observed when TREX1 and TREX2 pathways become aberrant, and autoimmune or cancerous diseases ensue. Manils et al. have now shown that overexpression of TREX2 may play a role in potentiating psoriasis. Thus, these pathways are likely targets for novel therapeutics.
authors.affiliation: Department of Dermatology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. Electronic address: alicia@pitt.edu.
authors.forename: Alicia R
authors.initials: AR
authors.lastname: Mathers
mesh_terms: D000818:Animals; D016022:Case-Control Studies; D018450:Disease Progression; D005090:Exodeoxyribonucleases / Q000235:genetics / Q000378:metabolism*; D005819:Genetic Markers; D006706:Homeostasis / Q000235:genetics; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D010750:Phosphoproteins / Q000235:genetics / Q000378:metabolism*; D011565:Psoriasis / Q000235:genetics / Q000503:physiopathology; D012016:Reference Values; D012871:Skin Diseases / Q000235:genetics* / Q000473:pathology*
chemical_list: D005819:Genetic Markers; D010750:Phosphoproteins; D005090:Exodeoxyribonucleases; C486104:TREX2 protein, human; C429526:three prime repair exonuclease 1