title: How can lipid nanocarriers improve transdermal delivery of olanzapine?
abstract: The development of a transdermal nanocarrier drug delivery system with potential for the treatment of psychiatric disorders, such as schizophrenia and bipolar disorder, is described. Lipid nanocarriers (LN), encompassing various solid:liquid lipid compositions were formulated and assessed as potential nanosystems for transdermal delivery of olanzapine. A previously optimized method of hot high pressure homogenization (HPH) was adopted for the production of the LN, which comprised solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC) and nanoemulsions (NE). Precirol®was selected as the solid lipid for progression of studies. SLN exhibited the best performance for transdermal delivery of olanzapine, based on in vitro release and permeation studies, coupled with results from physicochemical characterization of several solid:liquid lipid formulations. Stability tests, performed to give an indication of long-term storage behavior of the formulations, were in good agreement with previous studies for the best choice of solid:liquid lipid ratio. Overall, these findings highlight the SLN-based formulation as promising for the further inclusion in and production of transdermal patches, representing an innovative therapeutic approach.
authors.affiliation: a University College London School of Pharmacy , London , UK.
authors.forename: Nimra
authors.initials: N
authors.lastname: Iqbal
authors.affiliation: b Faculty of Pharmacy, University of Coimbra , Coimbra , Portugal.|c Pharmacometrics Group of the Centre for Neurosciences and Cell Biology (CNC) , University of Coimbra , Coimbra , Portugal.
authors.forename: Carla
authors.initials: C
authors.lastname: Vitorino
authors.affiliation: a University College London School of Pharmacy , London , UK.
authors.forename: Kevin M G
authors.initials: KM
authors.lastname: Taylor
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D014150:Antipsychotic Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D001569:Benzodiazepines / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D004337:Drug Carriers / Q000737:chemistry*; D008055:Lipids / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry; D000077152:Olanzapine; D012867:Skin / Q000378:metabolism; D012869:Skin Absorption; D013552:Swine
chemical_list: D014150:Antipsychotic Agents; D004337:Drug Carriers; D008055:Lipids; D001569:Benzodiazepines; D000077152:Olanzapine
keywords: Lipid nanocarriers; nanoemulsions; nanostructured lipid carriers; olanzapine; solid lipid nanoparticles; transdermal drug delivery system