title: Successful Cord Blood Stem Cell Transplantation for an Adult Case of Chronic Active Epstein-Barr Virus Infection.
abstract: A 41-year-old man was referred to our hospital for treatment of anaplastic lymphoma kinase (ALK)-negative anaplastic large cell lymphoma. Chronic active Epstein-Barr virus (CAEBV) was diagnosed based on the findings of elevated EBV antibody titers and positive EBV-DNA in the peripheral blood, and cord blood stem cell transplantation (CBT) was performed. The EBV-DNA levels in the blood fell below the limit of detection. His lymphoma relapsed on Day 165 with the appearance of eruptions, which disappeared after the withdrawal of tacrolimus. One year after transplantation, there were no signs of recurrence. This encouraging result suggests that CBT should be considered for adult cases of CAEBV with aggressive clinical manifestations.
authors.affiliation: Department of Medical Oncology and Hematology, Oita University Faculty of Medicine, Japan.
authors.forename: Masuho
authors.initials: M
authors.lastname: Saburi
authors.forename: Masao
authors.initials: M
authors.lastname: Ogata
authors.forename: Takako
authors.initials: T
authors.lastname: Satou
authors.forename: Natsumi
authors.initials: N
authors.lastname: Yoshida
authors.forename: Kentaro
authors.initials: K
authors.lastname: Nagamatsu
authors.forename: Yuko
authors.initials: Y
authors.lastname: Nashimoto
authors.forename: Yui
authors.initials: Y
authors.lastname: Moroga
authors.forename: Kuniko
authors.initials: K
authors.lastname: Takano
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Kohno
authors.forename: Kuniaki
authors.initials: K
authors.lastname: Shirao
mesh_terms: D000328:Adult; D001706:Biopsy; D002908:Chronic Disease; D036101:Cord Blood Stem Cell Transplantation / Q000379:methods*; D020031:Epstein-Barr Virus Infections / Q000175:diagnosis / Q000601:surgery*; D004854:Herpesvirus 4, Human; D006801:Humans; D008297:Male