title: Cell adhesion molecules and sleep.
abstract: Cell adhesion molecules (CAMs) play essential roles in the central nervous system, where some families are involved in synaptic development and function. These synaptic adhesion molecules (SAMs) are involved in the regulation of synaptic plasticity, and the formation of neuronal networks. Recent findings from studies examining the consequences of sleep loss suggest that these molecules are candidates to act in sleep regulation. This review highlights the experimental data that lead to the identification of SAMs as potential sleep regulators, and discusses results supporting that specific SAMs are involved in different aspects of sleep regulation. Further, some potential mechanisms by which SAMs may act to regulate sleep are outlined, and the proposition that these molecules may serve as molecular machinery in the two sleep regulatory processes, the circadian and homeostatic components, is presented. Together, the data argue that SAMs regulate the neuronal plasticity that underlies sleep and wakefulness.
authors.affiliation: Research Centre and Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, 5400 Gouin West Blvd. Montreal, QC, H4J 1C5, Canada; Department of Neuroscience, Université de Montréal, C.P. 6128, succ. Centre-Ville, Montreal, QC, H3C 3J7, Canada.
authors.forename: Emma Kate
authors.initials: EK
authors.lastname: O'Callaghan
authors.affiliation: Research Centre and Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, 5400 Gouin West Blvd. Montreal, QC, H4J 1C5, Canada; Neurophysiology of Sleep and Biology Rhythms Laboratory, IDISPA (Health Research Foundation Illes Balears), University of Balearic Islands, Palma de Mallorca 07122, Spain.
authors.forename: Maria Neus
authors.initials: MN
authors.lastname: Ballester Roig
authors.affiliation: Research Centre and Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, 5400 Gouin West Blvd. Montreal, QC, H4J 1C5, Canada; Department of Neuroscience, Université de Montréal, C.P. 6128, succ. Centre-Ville, Montreal, QC, H3C 3J7, Canada,. Electronic address: valerie.mongrain@umontreal.ca.
authors.forename: Valérie
authors.initials: V
authors.lastname: Mongrain
mesh_terms: D000818:Animals; D002450:Cell Communication; D002940:Circadian Rhythm; D006801:Humans; D019006:Neural Cell Adhesion Molecules / Q000235:genetics / Q000502:physiology*; D009457:Neuroglia / Q000502:physiology; D009473:Neuronal Plasticity; D009474:Neurons / Q000502:physiology; D012890:Sleep / Q000502:physiology*; D012893:Sleep Wake Disorders / Q000378:metabolism / Q000503:physiopathology; D013569:Synapses / Q000378:metabolism; D014851:Wakefulness / Q000502:physiology
chemical_list: D019006:Neural Cell Adhesion Molecules
keywords: Ephrin; Neurexin; Neuroligin; Sleep deprivation; Sleep homeostasis; Synaptic adhesion molecules; Synaptic transmission