title: Risk factors for Propionibacterium acnes infection after neurosurgery: A case-control study.
abstract: Propionibacterium acnes is increasingly known as a causative organism for post-neurosurgical infection; however, no clinical studies have examined the risk factors associated with P. acnes infections. Clinical data obtained from 14 cases of P. acnes infection and 28 controls infected with other pathogens were analyzed. Craniotomy, malignancy, and prolonged duration of operation were significantly associated with the onset of P. acnes infection. No fatal cases were reported.
authors.affiliation: Department of Pharmacy, Tsuyama Chuo Hospital, Japan.
authors.forename: Yuto
authors.initials: Y
authors.lastname: Haruki
authors.affiliation: Department of Infection Control and Prevention, Osaka University Graduate School of Medicine, Japan. Electronic address: highgear@hp-infect.med.osaka-u.ac.jp.
authors.forename: Hideharu
authors.initials: H
authors.lastname: Hagiya
authors.affiliation: Department of Neurological Surgery, Okayama University Graduate School of Medicine, Japan.
authors.forename: Yu
authors.initials: Y
authors.lastname: Takahashi
authors.affiliation: Department of Neurosurgery, Tsuyama Chuo Hospital, Japan.
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Yoshida
authors.affiliation: Department of Neurosurgery, Tsuyama Chuo Hospital, Japan.
authors.forename: Kazuki
authors.initials: K
authors.lastname: Kobayashi
authors.affiliation: Department of Neurosurgery, Tsuyama Chuo Hospital, Japan.
authors.forename: Tadato
authors.initials: T
authors.lastname: Yukiue
authors.affiliation: Department of Neurosurgery, Tsuyama Chuo Hospital, Japan.
authors.forename: Nobushige
authors.initials: N
authors.lastname: Tsuboi
authors.affiliation: Department of Pharmacy, Tsuyama Chuo Hospital, Japan.
authors.forename: Tetsuhiro
authors.initials: T
authors.lastname: Sugiyama
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D005260:Female; D016908:Gram-Positive Bacterial Infections / Q000209:etiology* / Q000382:microbiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009493:Neurosurgery / Q000379:methods; D019635:Neurosurgical Procedures / Q000009:adverse effects*; D011425:Propionibacterium acnes / Q000472:pathogenicity*; D012307:Risk Factors; D013530:Surgical Wound Infection / Q000209:etiology* / Q000382:microbiology*
keywords: Post-cranioplasty neurosurgical infection; Post-operative central nervous system infection; Propionibacterium acnes; Surgical site infection