title: Distinct patterns of imprecise consonant articulation among Parkinson's disease, progressive supranuclear palsy and multiple system atrophy.
abstract: Distinct speech characteristics that may aid in differentiation between Parkinson's disease (PD), progressive supranuclear palsy (PSP) and multiple system atrophy (MSA) remain tremendously under-explored. Here, the patterns and degree of consonant articulation deficits across voiced and voiceless stop plosives in 16 PD, 16 PSP, 16 MSA and 16 healthy control speakers were evaluated using acoustic and perceptual methods. Imprecise consonant articulation was observed across all Parkinsonian groups. Voice onset time of voiceless plosives was more prolonged in both PSP and MSA compared to PD, presumably due to greater severity of dysarthria and slower articulation rate. Voice onset time of voiced plosives was significantly shorter only in MSA, likely as a consequence of damage to cerebellar structures. In agreement with the reduction of pre-voicing, MSA manifested increased number of voiced plosives misclassified as voiceless at perceptual evaluation. Timing of articulatory movements may provide important clues about the pathophysiology of underlying disease.
authors.affiliation: Department of Circuit Theory, Faculty of Electrical Engineering, Czech Technical University in Prague, Technicka 2, 166 27 Prague 6, Czech Republic.
authors.forename: Tereza
authors.initials: T
authors.lastname: Tykalova
authors.affiliation: Department of Circuit Theory, Faculty of Electrical Engineering, Czech Technical University in Prague, Technicka 2, 166 27 Prague 6, Czech Republic; Department of Neurology and Centre of Clinical Neuroscience, First Faculty of Medicine, Charles University in Prague, Katerinska 30, 120 00 Prague 2, Czech Republic. Electronic address: rusz.mz@gmail.com.
authors.forename: Jan
authors.initials: J
authors.lastname: Rusz
authors.affiliation: Department of Neurology and Centre of Clinical Neuroscience, First Faculty of Medicine, Charles University in Prague, Katerinska 30, 120 00 Prague 2, Czech Republic; Institute of Anatomy, First Faculty of Medicine, Charles University in Prague, U nemocnice 3, 128 00 Prague 2, Czech Republic.
authors.forename: Jiri
authors.initials: J
authors.lastname: Klempir
authors.affiliation: Department of Circuit Theory, Faculty of Electrical Engineering, Czech Technical University in Prague, Technicka 2, 166 27 Prague 6, Czech Republic.
authors.forename: Roman
authors.initials: R
authors.lastname: Cmejla
authors.affiliation: Department of Neurology and Centre of Clinical Neuroscience, First Faculty of Medicine, Charles University in Prague, Katerinska 30, 120 00 Prague 2, Czech Republic.
authors.forename: Evzen
authors.initials: E
authors.lastname: Ruzicka
mesh_terms: D000368:Aged; D002531:Cerebellum / Q000503:physiopathology; D004401:Dysarthria / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008037:Linguistics; D008297:Male; D008875:Middle Aged; D019578:Multiple System Atrophy / Q000503:physiopathology*; D010300:Parkinson Disease / Q000503:physiopathology*; D013060:Speech; D013494:Supranuclear Palsy, Progressive / Q000503:physiopathology*; D014831:Voice
keywords: Acoustic analysis; Atypical Parkinsonian syndromes; Dysarthria; Parkinson’s disease; Perceptual assessment; Speech disorders; Voice onset time