title: Expression and methylation of circulating microRNA-510 in essential hypertension.
abstract: Hypertension (HTN) is one of the most common emerging disease in developing countries. It alters endothelial cell structure and function, resulting in several diseases, such as cardiovascular disease, peripheral vasculopathy, cerebrovascular disease and nephropathy. Although much progress has been made in researching HTN in recent years, early diagnosis and treatment of HTN are not yet satisfactory, and progression control/treatment is still poor. MicroRNAs are well-known regulators of the physiological and developmental processes of HTN. Our results revealed that miR-510 was upregulated in blood samples from HTN patients, whereas no significant differences were observed in the control samples. Methylation analyses corroborated the miR-510 upregulation in patient samples. These results suggested that miR-510 can be used as a novel biomarker for diagnosis and as a new therapeutic target for HTN.
authors.affiliation: Advance Research Centre, Narayana Medical College and Hospital, Nellore, India.
authors.forename: Ramalingam
authors.initials: R
authors.lastname: Krishnan
authors.affiliation: Department of Biotechnology, Annai College of Arts and Science, Kumbakonam, India.
authors.forename: Panagal
authors.initials: P
authors.lastname: Mani
authors.affiliation: Department of Zoology, Arumugam Pillai Seethai Ammal College, Tiruppattur, India.
authors.forename: Pethanen
authors.initials: P
authors.lastname: Sivakumar
authors.affiliation: Department of Zoology, Arumugam Pillai Seethai Ammal College, Tiruppattur, India.
authors.forename: Vincent
authors.initials: V
authors.lastname: Gopinath
authors.affiliation: Advance Research Centre, Narayana Medical College and Hospital, Nellore, India.
authors.forename: Durairaj
authors.initials: D
authors.lastname: Sekar
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure / Q000502:physiology; D019175:DNA Methylation; D000075222:Essential Hypertension; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000235:genetics; D008297:Male; D035683:MicroRNAs / Q000097:blood* / Q000235:genetics; D008875:Middle Aged
chemical_list: D015415:Biomarkers; C582676:MIRN501 microRNA, human; D035683:MicroRNAs