title: Ectopic Fat Deposition on Insulin Sensitivity: Correlation of Hepatocellular Lipid Content andMValue.
abstract: Purpose. This study aimed to explore the relationship among insulin sensitivity and ectopic fat depots in participants with different glucose status.Methods. Fifty-nine men and women were enrolled in this study: 29 with normal glucose tolerance (NGT), 17 with impaired glucose tolerance (IGT), and 13 with type 2 diabetes mellitus (T2DM). All participants underwent a hyperinsulinemic-euglycemic clamp to assess the insulin sensitivity index (Mvalue) and magnetic resonance imaging to measure the hepatocellular lipid content (HCL), skeletal muscle fat content including intramyocellular lipid (IMCL) and extramyocellular lipid (EMCL) of tibialis anterior (ta), and soleus muscle (sol).Results. TheMvalue of NGT group was higher than those of IGT and T2DM groups (P= 0.001). Participants with T2DM had the highest HCL and IMCL (ta) compared with those in NGT and IGT groups (P= 0.001). TheMvalue had an inverse relationship with HCL (r= -0.789,P= 0.001), IMCL (sol) (r= -0.427,P= 0.002), and IMCL (ta) (r= -0.419,P= 0.002). Stepwise linear regression analysis showed that HCL (standardizedβ= -0.416;P= 0.001) had an independent relationship withMvalue.Conclusions. Hepatocellular lipid content deposition happens earlier than skeletal muscle fat deposition. HCL is an independent risk factor for insulin resistance and may be used to evaluate the risk of developing T2DM as a noninvasive marker of insulin sensitivity index.
authors.affiliation: Department of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: Beverly S
authors.identifier: 0000-0002-2579-3276
authors.initials: BS
authors.lastname: Hong
authors.affiliation: Department of Hematology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Endocrinology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
authors.forename: Shuiqing
authors.initials: S
authors.lastname: Lai
authors.affiliation: Department of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: Hongyu
authors.identifier: 0000-0001-9688-4610
authors.initials: H
authors.lastname: Guan
authors.affiliation: Department of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: Weijian
authors.initials: W
authors.lastname: Ke
authors.affiliation: Department of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: Xiaoying
authors.initials: X
authors.lastname: He
authors.affiliation: Department of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: Yanbing
authors.identifier: 0000-0001-7242-760X
authors.initials: Y
authors.lastname: Li
mesh_terms: D000273:Adipose Tissue / Q000000981:diagnostic imaging*; D000328:Adult; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism*; D005260:Female; D015309:Glucose Clamp Technique; D018149:Glucose Intolerance / Q000378:metabolism*; D022781:Hepatocytes / Q000378:metabolism*; D006801:Humans; D007333:Insulin Resistance; D050356:Lipid Metabolism; D008055:Lipids; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D032342:Muscle Cells / Q000378:metabolism*; D018482:Muscle, Skeletal / Q000000981:diagnostic imaging*; D066244:Proton Magnetic Resonance Spectroscopy
chemical_list: D008055:Lipids