title: Three new drimane sesquiterpenoids from cultures of the fungus Penicillium sp.
abstract: Three new drimane sesquiterpenoids, 12-hydroxyalbrassitriol (1), drim-8(12)-en-6β,7α, 9α,11-tetraol (2), and drim-68(12)-dien-9α,11-diol (3), along with one known analog albrassitriol (4), were isolated from cultures of the tin mine tailings-associated fungus Penicillium sp. The new structures were determined on the basis of extensive spectroscopic analyses. All compounds were tested for their cytotoxicities against five human cancer cell lines.
authors.affiliation: a Engineering and Technology Research Center of Liupanshan Resources, College of Chemistry and Chemical Engineering , Ningxia Normal University , Guyuan 756000 , China.
authors.forename: Jian-Hai
authors.initials: JH
authors.lastname: Ding
authors.affiliation: b Key Laboratory for Microbial Resources, Ministry of Education , Yunnan Institute of Microbiology, Yunnan University , Kunming 650091 , China.
authors.forename: Zhang-Gui
authors.initials: ZG
authors.lastname: Ding
authors.affiliation: b Key Laboratory for Microbial Resources, Ministry of Education , Yunnan Institute of Microbiology, Yunnan University , Kunming 650091 , China.
authors.forename: Wei-Xun
authors.initials: WX
authors.lastname: Chunyu
authors.affiliation: b Key Laboratory for Microbial Resources, Ministry of Education , Yunnan Institute of Microbiology, Yunnan University , Kunming 650091 , China.
authors.forename: Jiang-Yuan
authors.initials: JY
authors.lastname: Zhao
authors.affiliation: a Engineering and Technology Research Center of Liupanshan Resources, College of Chemistry and Chemical Engineering , Ningxia Normal University , Guyuan 756000 , China.
authors.forename: Hai-Bin
authors.initials: HB
authors.lastname: Wang
authors.affiliation: a Engineering and Technology Research Center of Liupanshan Resources, College of Chemistry and Chemical Engineering , Ningxia Normal University , Guyuan 756000 , China.
authors.forename: Shi-Wei
authors.initials: SW
authors.lastname: Liu
authors.affiliation: c BioBioPha Co., Ltd. , Kunming 650201 , China.
authors.forename: Fei
authors.initials: F
authors.lastname: Wang
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002681:China; D004354:Drug Screening Assays, Antitumor; D018922:HL-60 Cells; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010407:Penicillium / Q000737:chemistry*; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: C000622132:12-hydroxyalbrassitriol; D000970:Antineoplastic Agents; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; C437376:drimane
keywords: Penicillium sp.; cytotoxicities; drimane sesquiterpenoids; fungus