title: New Xymedon Analogues for Stimulation of Posttraumatic Regeneration of the Spinal Cord in Rats.
abstract: Effect of systemic administration of synthetic pyrimidine derivatives, xymedon and compounds 29D and 34D, was studied in rats with experimental dosed contusion spinal cord injury. Xymedon promoted recovery of motor function after injury. Compounds 29D and 34D more effectively restored the parameters of open-field and Rotarod tests in comparison with xymedon. Compound 29D more effectively than xymedon maintained the number of Olig2+oligodendrocytes in the corticospinal tract and NG2 cells in all investigated areas of the white matter. In the group treated with compound 34D, the differences in the number of NG2+cells were revealed only in the anterior funiculi, where the number of these glial cells was 2-fold higher than in the xymedon-treated group. Obtained results suggest that the studied xymedon analogs, compounds 29D and 34D, can exert their therapeutic action through different molecular and cellular pathways.
authors.affiliation: Laboratory of Nucleobases Chemistry, A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center of Russian Academy of Sciences, Kazan, Russia. t.povysheva@gmail.com.
authors.forename: T V
authors.initials: TV
authors.lastname: Povysheva
authors.affiliation: Laboratory of Nucleobases Chemistry, A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center of Russian Academy of Sciences, Kazan, Russia.
authors.forename: V E
authors.initials: VE
authors.lastname: Semenov
authors.affiliation: Laboratory of Nucleobases Chemistry, A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center of Russian Academy of Sciences, Kazan, Russia.
authors.forename: I V
authors.initials: IV
authors.lastname: Galyametdinova
authors.affiliation: Laboratory of Nucleobases Chemistry, A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center of Russian Academy of Sciences, Kazan, Russia.
authors.forename: V S
authors.initials: VS
authors.lastname: Reznik
authors.affiliation: Department of Histology, Cytology and Embryology, Kazan State Medical University of Ministry of Health of Russian Federation, Kazan, Russia.
authors.forename: K S
authors.initials: KS
authors.lastname: Knni
authors.affiliation: Department of Histology, Cytology and Embryology, Kazan State Medical University of Ministry of Health of Russian Federation, Kazan, Russia.
authors.forename: P E
authors.initials: PE
authors.lastname: Kolesnikov
authors.affiliation: Department of Histology, Cytology and Embryology, Kazan State Medical University of Ministry of Health of Russian Federation, Kazan, Russia.
authors.forename: Yu A
authors.initials: YA
authors.lastname: Chelyshev
mesh_terms: D000818:Animals; D000941:Antigens / Q000235:genetics / Q000378:metabolism; D051792:Basic Helix-Loop-Helix Proteins / Q000235:genetics / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism; D002452:Cell Count; D015870:Gene Expression; D009413:Nerve Fibers, Myelinated / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D009416:Nerve Regeneration / Q000187:drug effects*; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism; D009457:Neuroglia / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D018696:Neuroprotective Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D000076104:Oligodendrocyte Transcription Factor 2; D009836:Oligodendroglia / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D011509:Proteoglycans / Q000235:genetics / Q000378:metabolism; D011743:Pyrimidines / Q000138:chemical synthesis / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D020127:Recovery of Function / Q000187:drug effects*; D045442:Rotarod Performance Test; D013116:Spinal Cord / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D013119:Spinal Cord Injuries / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D066127:White Matter / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D000099216:Chondroitin Sulfate Proteoglycan 4
chemical_list: D000941:Antigens; D051792:Basic Helix-Loop-Helix Proteins; D015415:Biomarkers; D009419:Nerve Tissue Proteins; D018696:Neuroprotective Agents; D000076104:Oligodendrocyte Transcription Factor 2; D011509:Proteoglycans; D011743:Pyrimidines; D000099216:Chondroitin Sulfate Proteoglycan 4; C522729:Olig2 protein, rat; C069705:xymedon
keywords: pyrimidine; spinal cord injury; xymedon