title: Organization and functions of mGlu and GABABreceptor complexes.
abstract: The neurotransmitters glutamate and γ-aminobutyric acid (GABA) transmit synaptic signals by activating fast-acting ligand-gated ion channels and more slowly acting G-protein-coupled receptors (GPCRs). The GPCRs for these neurotransmitters, metabotropic glutamate (mGlu) and GABABreceptors, are atypical GPCRs with a large extracellular domain and a mandatory dimeric structure. Recent studies have revealed how these receptors are activated through multiple allosteric interactions between subunit domains. It emerges that the molecular complexity of these receptors is further increased through association with trafficking, effector and regulatory proteins. The structure and composition of these receptors present opportunities for therapeutic intervention in mental health and neurological disorders.
authors.affiliation: Centre National de la Recherche Scientifique UMR 5203, Institut de Génomique Fonctionnelle, Université de Montpellier, F-34094 Montpellier, France.|INSERM, U1191, F-34094 Montpellier, France.
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Pin
authors.affiliation: Department of Biomedicine, Pharmazentrum, University of Basel, Klingelbergstrasse 50/70, CH-4056 Basel, Switzerland.
authors.forename: Bernhard
authors.initials: B
authors.lastname: Bettler
mesh_terms: D000495:Allosteric Site; D000818:Animals; D055808:Drug Discovery; D006801:Humans; D046912:Multiprotein Complexes / Q000737:chemistry / Q000378:metabolism*; D060066:Protein Interaction Maps; D018343:Receptors, Adrenergic, beta-2 / Q000737:chemistry / Q000378:metabolism; D018080:Receptors, GABA-B / Q000378:metabolism*; D018094:Receptors, Metabotropic Glutamate / Q000037:antagonists & inhibitors / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D046912:Multiprotein Complexes; D018343:Receptors, Adrenergic, beta-2; D018080:Receptors, GABA-B; D018094:Receptors, Metabotropic Glutamate