title: Association of Preoperative Platelet-to-Lymphocyte Ratio with Atrial Fibrillation after Coronary Artery Bypass Graft Surgery.
abstract: OBJECTIVE
  The aim of this study was to investigate the association between platelet-to-lymphocyte ratio (PLR) and atrial fibrillation (AF) after coronary artery bypass graft (CABG) surgery.
  
  
  METHODS
  A total of 125 patients were retrospectively analyzed. AF was diagnosed using standard clinical criteria, and PLR was calculated as the ratio of the platelets to lymphocytes, obtained from the blood samples that were taken in the fasting state before CABG surgery. The association of different variables with postoperative AF and PLR was calculated using univariate and multivariate analysis. The receiver operating characteristics curve was used to determine the sensitivity and specificity of PLR and the optimal cutoff value for predicting post-CABG AF.
  
  
  RESULTS
  Of the 125 patients, 50 with AF (mean age: 67.0 ± 9.5 years, 38 males and 12 females) and 75 patients without AF (mean age: 61.1 ± 9.1 years, 58 males and 17 females) were identified, and the difference in the mean age was statistically significant (p = 0.01). PLR was also significantly higher in those with AF (152.8 ± 82.2) than those without AF (118.2 ± 32.9) (p = 0.012). Univariate analysis showed that age and PLR were associated with AF after CABG surgery (p < 0.001 and p = 0.005, respectively). Using a multivariate logistic regression model with the backward elimination method, age and PLR remained as independent predictors of AF after CABG surgery (p < 0.001 and p = 0.005, respectively). PLR levels >119.3 predicted postoperative AF with 64% sensitivity and 56% specificity (AUC: 0.634, p = 0.012).
  
  
  CONCLUSIONS
  In this study, age and PLR level were independent predictors of AF after CABG surgery. Patients with an elevated preoperative PLR were at higher risk of AF after CABG surgery.
authors.affiliation: Department of Cardiology, Adnan Menderes University, Aydin, Turkey.
authors.forename: Hasan
authors.initials: H
authors.lastname: Gungor
authors.forename: Abraham Samuel
authors.initials: AS
authors.lastname: Babu
authors.forename: Cemil
authors.initials: C
authors.lastname: Zencir
authors.forename: Mahmut
authors.initials: M
authors.lastname: Akpek
authors.forename: Mithat
authors.initials: M
authors.lastname: Selvi
authors.forename: Muhammet Huseyin
authors.initials: MH
authors.lastname: Erkan
authors.forename: Selim
authors.initials: S
authors.lastname: Durmaz
mesh_terms: D000367:Age Factors; D000368:Aged; D001281:Atrial Fibrillation / Q000097:blood / Q000209:etiology*; D001792:Blood Platelets / Q000378:metabolism*; D001026:Coronary Artery Bypass / Q000009:adverse effects*; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000097:blood / Q000209:etiology*; D012372:ROC Curve; D018570:Risk Assessment; D012737:Sex Factors