title: Migration, recombination, and reassortment are involved in the evolution of severe fever with thrombocytopenia syndrome bunyavirus.
abstract: Severe fever with thrombocytopenia syndrome bunyavirus (SFTSV) has been identified as the etiological agent causing severe fever with thrombocytopenia syndrome (SFTS). SFTSV was reported in recent years as a newly emerging tick-borne virus in China, Japan and South Korea and is a novel member of the genus Phlebovirus, family Bunyaviridae, which is suspected to be transmitted by the tick Haemaphysalis longicornis. The genetic diversity and evolutionary relationships between geographically distributed SFTSV strains are currently unclear. In this study we used extensive bioinformatics analyses to provide deep insight into the mechanisms of evolution and relationships among SFTSV strains. The genetic diversity of SFTSV was characterized and found to be generated through recombination and reassortment events. Further, potential correlations between the geographic distribution and migration pathways of SFTSV were subject to in-depth analysis. The potential of birds migration related to SFTSV migration were also discussed. The results of this study will facilitate better understanding of the mechanisms of evolution of SFTSV, which will be important in developing public-health interventions and strategies for SFTS disease control and prevention in endemic areas.
authors.affiliation: State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China.
authors.forename: Junming
authors.initials: J
authors.lastname: Shi
authors.affiliation: School of Information Engineering, China University of Geosciences, Wuhan, PR China.
authors.forename: Sheng
authors.initials: S
authors.lastname: Hu
authors.affiliation: State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China.
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Yang
authors.affiliation: School of Medicine, Wuhan University of Science and Technology, Wuhan, PR China.
authors.forename: Dan
authors.initials: D
authors.lastname: Liu
authors.affiliation: School of Information Engineering, China University of Geosciences, Wuhan, PR China.
authors.forename: Liang
authors.initials: L
authors.lastname: Wu
authors.affiliation: State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China.
authors.forename: Hualin
authors.initials: H
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China.
authors.forename: Zhihong
authors.initials: Z
authors.lastname: Hu
authors.affiliation: State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Deng
authors.affiliation: State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China. Electronic address: shenshu@wh.iov.cn.
authors.forename: Shu
authors.initials: S
authors.lastname: Shen
mesh_terms: D025041:Animal Migration; D000818:Animals; D001717:Birds / Q000821:virology; D002044:Bunyaviridae Infections / Q000635:transmission / Q000821:virology*; D005202:Asia, Eastern; D006801:Humans; D016856:Phlebovirus / Q000145:classification / Q000235:genetics; D010802:Phylogeny; D016865:Reassortant Viruses / Q000145:classification / Q000235:genetics; D011995:Recombination, Genetic
keywords: Genetic diversity; Migration; Phylogenetic analysis; Recombination,reassortment; SFTSV