title: WONOEP appraisal: Imaging biomarkers in epilepsy.
abstract: Neuroimaging offers a wide range of opportunities to obtain information about neuronal activity, brain inflammation, blood-brain barrier alterations, and various molecular alterations during epileptogenesis or for the prediction of pharmacoresponsiveness as well as postoperative outcome. Imaging biomarkers were examined during the XIII Workshop on Neurobiology of Epilepsy (XIII WONOEP) organized in 2015 by the Neurobiology Commission of the International League Against Epilepsy (ILAE). Here we present an extended summary of the discussed issues and provide an overview of the current state of knowledge regarding the biomarker potential of different neuroimaging approaches for epilepsy.
authors.affiliation: Department of (Neuro)Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
authors.forename: Erwin A
authors.initials: EA
authors.lastname: van Vliet
authors.affiliation: Department of Translational Neurosciences, University of Antwerp, Wilrijk, Belgium.
authors.forename: Stefanie
authors.initials: S
authors.lastname: Dedeurwaerdere
authors.affiliation: Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, U.S.A.
authors.forename: Andrew J
authors.identifier: 0000-0002-0828-826X
authors.initials: AJ
authors.lastname: Cole
authors.affiliation: Department of Brain and Cognitive Sciences, Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, Beer Sheva, Israel.|Department of Medical Neuroscience, Dalhousie University, Halifax, Nova Scotia, Canada.
authors.forename: Alon
authors.initials: A
authors.lastname: Friedman
authors.affiliation: Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, United Kingdom.
authors.forename: Matthias J
authors.initials: MJ
authors.lastname: Koepp
authors.affiliation: Institute of Pharmacology, Toxicology and Pharmacy, Ludwig-Maximilian-University, Munich, Germany.
authors.forename: Heidrun
authors.initials: H
authors.lastname: Potschka
authors.affiliation: Department of Neurobiology, A I Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
authors.forename: Riikka
authors.initials: R
authors.lastname: Immonen
authors.affiliation: Department of Neurobiology, A I Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
authors.forename: Asla
authors.initials: A
authors.lastname: Pitkänen
authors.affiliation: Departments of Clinical Neurosciences and Radiology, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada.
authors.forename: Paolo
authors.initials: P
authors.lastname: Federico
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D001812:Blood-Brain Barrier / Q000503:physiopathology; D004493:Education; D004827:Epilepsy / Q000175:diagnosis / Q000378:metabolism / Q000628:therapy; D006801:Humans; D009446:Neurobiology; D059906:Neuroimaging
chemical_list: D015415:Biomarkers
keywords: Biomarker; Blood-brain barrier; Epileptogenesis; Imaging; Inflammation; Traumatic brain injury