title: Prospective evaluation of the Ages and Stages Questionnaire 3rd Edition in very-low-birthweight infants.
abstract: To evaluate the predictive and concurrent diagnostic agreement of the Ages and Stages Questionnaire 3rd Edition (ASQ-3) with the Bayley Scales of Infant and Toddler Development 3rd Edition (Bayley-III) in infants born preterm and very-low-birthweight (PT/VLBW; ≤1250g).
  
  
  
  We evaluated 141 PT/VLBW infants (68 males, 73 females) born at the KK Women's and Children's Hospital between January 2010 and December 2011, to determine predictive and concurrent diagnostic agreement between the ASQ-3 at 9, 12, 18, and 24 months corrected age and Bayley-III at 24 months. Cut-offs on the ASQ-3 at 24 months were estimated by receiver operating characteristic curves.
  
  
  
  Sixty (43%) and 25 (18%) failed in any domain of the ASQ-3 and Bayley-III (<70) respectively. A negative predictive value (NPV) >98% was achieved for the motor domain from 9 months, and >90% for the communication domain and the overall results at 24 months. Optimal referral ASQ-3 score at 24 months to achieve 100% NPV was 243.
  
  
  
  In PT/VLBW infants, ASQ-3 screening at 24 months can reduce the need for costly psychometric assessments in children with normal results. Clinicians can be assured of normal motor development at 9 months using the ASQ-3, but should continue to screen children on other domains.
authors.affiliation: Department of Neonatology, KK Women's and Children's Hospital, Singapore.
authors.forename: Pratibha K
authors.initials: PK
authors.lastname: Agarwal
authors.affiliation: Department of Epidemiology, Singapore Clinical Research Institute, Singapore.
authors.forename: Luming
authors.initials: L
authors.lastname: Shi
authors.affiliation: Department of Child Development, KK Women's and Children's Hospital, Singapore.
authors.forename: Lourdes M
authors.initials: LM
authors.lastname: Daniel
authors.affiliation: Department of Child Development, KK Women's and Children's Hospital, Singapore.
authors.forename: Phey Hong
authors.initials: PH
authors.lastname: Yang
authors.affiliation: Department of Neonatology, KK Women's and Children's Hospital, Singapore.
authors.forename: Poh Choo
authors.initials: PC
authors.lastname: Khoo
authors.affiliation: Department of Neonatology, KK Women's and Children's Hospital, Singapore.
authors.forename: Bin Huey
authors.initials: BH
authors.lastname: Quek
authors.affiliation: Department of Epidemiology, Singapore Clinical Research Institute, Singapore.
authors.forename: Qishi
authors.initials: Q
authors.lastname: Zheng
authors.affiliation: Department of Neonatology, KK Women's and Children's Hospital, Singapore.
authors.forename: Victor S
authors.initials: VS
authors.lastname: Rajadurai
mesh_terms: D000375:Aging; D002675:Child, Preschool; D015331:Cohort Studies; D002658:Developmental Disabilities / Q000175:diagnosis*; D005260:Female; D006801:Humans; D007223:Infant; D019102:Infant, Very Low Birth Weight / Q000523:psychology*; D008297:Male; D008423:Maternal Age; D011237:Predictive Value of Tests; D012372:ROC Curve; D012680:Sensitivity and Specificity; D011795:Surveys and Questionnaires