title: β-TCP porous pellets as an orthopaedic drug delivery system: ibuprofen/carrier physicochemical interactions.
abstract: Calcium phosphate bone substitute materials can be loaded with active substances forin situ, targeted drug administration. In this study, porous β-TCP pellets were investigated as an anti-inflammatory drug carrier. Porous β-TCP pellets were impregnated with an ethanolic solution of ibuprofen. The effects of contact time and concentration of ibuprofen solution on drug adsorption were studied. The ibuprofen adsorption equilibrium time was found to be one hour. The adsorption isotherms fitted to the Freundlich model, suggesting that the interaction between ibuprofen and β-TCP is weak. The physicochemical characterizations of loaded pellets confirmed that the reversible physisorption of ibuprofen on β-TCP pellets is due to Van der Waals forces, and this property was associated with the 100% ibuprofen release.
authors.affiliation: SPCTS-Centre Européen de la Céramique, 12 Rue Atlantis, 87068, Limoges CEDEX, France.
authors.forename: Hiba
authors.initials: H
authors.lastname: Baradari
authors.affiliation: SPCTS-Centre Européen de la Céramique, 12 Rue Atlantis, 87068, Limoges CEDEX, France.
authors.forename: Chantal
authors.initials: C
authors.lastname: Damia
authors.affiliation: SPCTS-Centre Européen de la Céramique, 12 Rue Atlantis, 87068, Limoges CEDEX, France.
authors.forename: Maggy
authors.initials: M
authors.lastname: Dutreih-Colas
authors.affiliation: SPCTS-Centre Européen de la Céramique, 12 Rue Atlantis, 87068, Limoges CEDEX, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Champion
authors.affiliation: SPCTS-Centre Européen de la Céramique, 12 Rue Atlantis, 87068, Limoges CEDEX, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Chulia
authors.affiliation: SPCTS-Centre Européen de la Céramique, 12 Rue Atlantis, 87068, Limoges CEDEX, France.
authors.forename: Marylène
authors.initials: M
authors.lastname: Viana
keywords: beta tricalcium phosphate; drug adsorption; drug delivery system; ibuprofen; porous pellets