title: Danger signals, inflammasomes, and the intricate intracellular lives of chlamydiae.
abstract: Chlamydiae are obligate intracellular bacterial pathogens, and as such are sensitive to alterations in the cellular physiology of their hosts. Chlamydial infections often cause pathologic consequences due to prolonged localized inflammation. Considerable advances have been made in the last few years regarding our understanding of how two key inflammation-associated signaling pathways influence the biology of Chlamydia infections: inflammation regulating purinergic signaling pathways significantly impact intracellular chlamydial development, and inflammasome activation modulates both chlamydial growth and infection mediated pro-inflammatory cytokine production. We review here elements of both pathways, presenting the latest developments contributing to our understanding of how chlamydial infections are influenced by inflammasomes and purinergic signaling.
authors.affiliation: University of Rochester Medical Center, Rochester, USA.
authors.forename: Matthew A
authors.initials: MA
authors.lastname: Pettengill
authors.affiliation: School of Kinesiology and Health Science, York University, Toronto, Ontario, Canada.
authors.forename: Ali
authors.initials: A
authors.lastname: Abdul-Sater
authors.affiliation: Laboratory of Immunophysiology, Carlos Chagas Filho Biophysics Institute of the Federal University of Rio de Janeiro, Brazil.
authors.forename: Robson
authors.initials: R
authors.lastname: Coutinho-Silva
authors.affiliation: Laboratory of Immunophysiology, Carlos Chagas Filho Biophysics Institute of the Federal University of Rio de Janeiro, Brazil; Department of Biomedical Sciences, University of the Pacific, Arthur Dugoni School of Dentistry, San Francisco, USA. Electronic address: dojcius@pacific.edu.
authors.forename: David M
authors.initials: DM
authors.lastname: Ojcius
mesh_terms: D002694:Chlamydiaceae Infections / Q000382:microbiology*; D006801:Humans; D058847:Inflammasomes / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology
chemical_list: D058847:Inflammasomes
keywords: Chlamydia; Immunology; Infection; Inflammation; Innate immunity