title: Roux-en-Y gastric bypass augments the feeding responses evoked by gastrin-releasing peptides.
abstract: Roux-en-Y gastric bypass (RYGB) is the most effective method for the treatment of obesity, and metabolic disease RYGB may reduce body weight by altering the feeding responses evoked by the short-term satiety peptides.
  
  
  
  Here, we measured meal size (MS, chow), intermeal interval (IMI) length, and satiety ratio (SR, IMI/MS; food consumed per a unit of time) by the small and the large forms of gastrin-releasing peptide (GRP) in rats, GRP-10 and GRP-29 (0, 0.1, 0.5 nmol/kg) infused in the celiac artery (CA, supplies stomach and upper duodenum) and the cranial mesenteric artery (CMA, supplies small and large intestine) in an RYGB rat model.
  
  
  
  GRP-10 reduced MS, prolonged the IMI, and increased the SR only in the RYGB group, whereas GRP-29 evoked these responses by both routes and in both groups.
  
  
  
  The RYGB procedure augments the feeding responses evoked by exogenous GRP, possibly by decreasing total food intake, increasing latency to the first meal, decreasing number of meals or altering the sites of action regulating MS and IMI length by the two peptides.
authors.affiliation: Gastroenterology Laboratory, Department of Biomedical Sciences, College of Veterinary Medicine, Tuskegee University, Tuskegee, Alabama.
authors.forename: Martha C
authors.initials: MC
authors.lastname: Washington
authors.affiliation: Gastroenterology Laboratory, Department of Biomedical Sciences, College of Veterinary Medicine, Tuskegee University, Tuskegee, Alabama.
authors.forename: Thaer R
authors.initials: TR
authors.lastname: Mhalhal
authors.affiliation: Obesity Research Center and the Metabolic Diseases Institute, University of Cincinnati, Cincinnati, Ohio.
authors.forename: Tanisha
authors.initials: T
authors.lastname: Johnson-Rouse
authors.affiliation: Obesity Research Center and the Metabolic Diseases Institute, University of Cincinnati, Cincinnati, Ohio.
authors.forename: Jose
authors.initials: J
authors.lastname: Berger
authors.affiliation: Gastroenterology Laboratory, Department of Biomedical Sciences, College of Veterinary Medicine, Tuskegee University, Tuskegee, Alabama.
authors.forename: John
authors.initials: J
authors.lastname: Heath
authors.affiliation: Obesity Research Center and the Metabolic Diseases Institute, University of Cincinnati, Cincinnati, Ohio.
authors.forename: Randy
authors.initials: R
authors.lastname: Seeley
authors.affiliation: Gastroenterology Laboratory, Department of Biomedical Sciences, College of Veterinary Medicine, Tuskegee University, Tuskegee, Alabama. Electronic address: sayeghai@mytu.tuskegee.edu.
authors.forename: Ayman I
authors.initials: AI
authors.lastname: Sayegh
mesh_terms: D000818:Animals; D001839:Bombesin / Q000008:administration & dosage / Q000494:pharmacology; D002445:Celiac Artery; D005247:Feeding Behavior / Q000187:drug effects* / Q000502:physiology; D015390:Gastric Bypass; D019886:Gastrin-Releasing Peptide / Q000008:administration & dosage / Q000494:pharmacology*; D007261:Infusions, Intra-Arterial; D008297:Male; D008638:Mesenteric Arteries; D010446:Peptide Fragments / Q000008:administration & dosage / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012528:Satiety Response / Q000187:drug effects / Q000502:physiology
chemical_list: D010446:Peptide Fragments; D019886:Gastrin-Releasing Peptide; C040794:neuromedin C; D001839:Bombesin
keywords: Celiac artery; Cranial mesenteric artery; Food intake; GRP; Roux-en-Y