title: REV-ERBα regulates Fgf21 expression in the liver via hepatic nuclear factor 6.
abstract: The circadian clock contributes to the timing of many body functions including metabolism and reproduction. The hepatokine fibroblast growth factor 21 (FGF21) is a critical metabolic regulator involved in modulation of fertility. Here we show that lack of the clock component REV-ERBα elevates FGF21 levels in liver and plasma. At the molecular level, REV-ERBα modulates the expression of FGF21 via the liver-specific hepatic nuclear factor 6 (HNF6). We conclude that REV-ERBα regulates metabolism and reproduction, at least in part, via regulation of Fgf21.
authors.affiliation: Department of Biology, Unit of Biochemistry, University of Fribourg, Fribourg CH1700, Switzerland.
authors.forename: Rohit
authors.initials: R
authors.lastname: Chavan
authors.affiliation: Service of Endocrinology, Diabetology and Metabolism, Lausanne University Hospital, Lausanne CH1011, Switzerland.
authors.forename: Nadia
authors.initials: N
authors.lastname: Preitner
authors.affiliation: Department of Biology, Unit of Biochemistry, University of Fribourg, Fribourg CH1700, Switzerland.
authors.forename: Takashi
authors.initials: T
authors.lastname: Okabe
authors.affiliation: Department of Biology, Unit of Biochemistry, University of Fribourg, Fribourg CH1700, Switzerland.
authors.forename: Laureen Mansencal
authors.initials: LM
authors.lastname: Strittmatter
authors.affiliation: Service of Endocrinology, Diabetology and Metabolism, Lausanne University Hospital, Lausanne CH1011, Switzerland.
authors.forename: Cheng
authors.initials: C
authors.lastname: Xu
authors.affiliation: Department of Biology, Unit of Biochemistry, University of Fribourg, Fribourg CH1700, Switzerland.
authors.forename: Jürgen A
authors.initials: JA
authors.lastname: Ripperger
authors.affiliation: Service of Endocrinology, Diabetology and Metabolism, Lausanne University Hospital, Lausanne CH1011, Switzerland.
authors.forename: Nelly
authors.initials: N
authors.lastname: Pitteloud
authors.affiliation: Department of Biology, Unit of Biochemistry, University of Fribourg, Fribourg CH1700, Switzerland urs.albrecht@unifr.ch.
authors.forename: Urs
authors.identifier: http://orcid.org/0000-0002-0663-8676
authors.initials: U
authors.lastname: Albrecht
keywords: Circadian clock; Physiology; Transcription