title: Serum glutathione peroxidase, xanthine oxidase, and superoxide dismutase activities and malondialdehyde levels in patients with Parkinson's disease.
abstract: Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc). Oxidative stress has been hypothesized to play a major role in the development of PD in various studies. This study assessed to investigate oxidative and anti-oxidative status in PD patients. We evaluated oxidant/antioxidant status by measuring serum malondialdehyde (MDA) levels, xanthine oxidase (XO) activities, and activities of antioxidant enzymes, namely, glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD). The study included 29 patients with PD and 32 healthy subjects as controls. Comparison of oxidative parameters in the patient and control groups revealed significantly higher GSH-Px and XO activities in the patient group. Serum MDA and SOD activities in PD patients were not significantly different from the controls. MDA was negatively correlated with duration of the PD and positively with age of onset. There was a negative correlation between SOD and Hoehn and Yahr (H&Y) stage. According to these results, we suggest that oxidative stress may contribute to the development of PD.
authors.affiliation: Department of Neurology, Ankara Education and Research Hospital, Ankara, Turkey. gokceburcu@gmail.com.
authors.forename: Burcu
authors.identifier: http://orcid.org/0000-0002-7365-5070
authors.initials: B
authors.lastname: Gökçe Çokal
authors.affiliation: Department of Neurology, Ankara Education and Research Hospital, Ankara, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Yurtdaş
authors.affiliation: Department of Neurology, Ankara Education and Research Hospital, Ankara, Turkey.
authors.forename: Selda
authors.initials: S
authors.lastname: Keskin Güler
authors.affiliation: Department of Neurology, Ankara Education and Research Hospital, Ankara, Turkey.
authors.forename: Hafize Nalan
authors.initials: HN
authors.lastname: Güneş
authors.affiliation: Department of Neurology, Ankara Education and Research Hospital, Ankara, Turkey.
authors.forename: Ceyla
authors.initials: C
authors.lastname: Ataç Uçar
authors.affiliation: Turkish Ministry of Health, Directorate of Health Services, Ankara, Turkey.
authors.forename: Bilal
authors.initials: B
authors.lastname: Aytaç
authors.affiliation: The Laboratory of Turkish Public Health Institution, Ankara, Turkey.
authors.forename: Zahide Esra
authors.initials: ZE
authors.lastname: Durak
authors.affiliation: Department of Neurology, Ankara Education and Research Hospital, Ankara, Turkey.
authors.forename: Tahir Kurtuluş
authors.initials: TK
authors.lastname: Yoldaş
authors.affiliation: Department of Medical Biochemistry, Ankara University Faculty of Medicine, Ankara, Turkey.
authors.forename: İlker
authors.initials: İ
authors.lastname: Durak
authors.affiliation: Department of Medical Biochemistry, Ankara University Faculty of Medicine, Ankara, Turkey.
authors.forename: Hikmet Can
authors.initials: HC
authors.lastname: Çubukçu
mesh_terms: D000368:Aged; D000975:Antioxidants / Q000032:analysis*; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D016877:Oxidants / Q000097:blood*; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000502:physiology*; D010300:Parkinson Disease / Q000097:blood* / Q000201:enzymology / Q000503:physiopathology*; D013482:Superoxide Dismutase / Q000097:blood; D014969:Xanthine Oxidase / Q000097:blood
chemical_list: D000975:Antioxidants; D016877:Oxidants; D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D014969:Xanthine Oxidase
keywords: Glutathione peroxidase; Malondialdehyde; Oxidative stress; Parkinson’s disease; Superoxide dismutase; Xanthine oxidase