title: Ghrelin function in human obesity and type 2 diabetes: a concise review.
abstract: The 28 amino acid hormone, ghrelin, has been found to have various effects on metabolism. This review will focus on the pathways integrated into ghrelin's effect within the hypothalamus, pancreas and adipocytes. The identification of molecules and pathways that regulate ghrelin-mediated lipid retention could establish new mechanisms underlying cellular energy homeostasis. The impact of acyl-ghrelin on glucose metabolism and lipid homeostasis may allow for novel preventative or early intervention therapeutic strategies to treat obesity related type 2 diabetes and associated metabolic dysfunction.
authors.affiliation: Diabetes Research Group, Institute of Life Science 1, Swansea University, Swansea, UK.
authors.forename: R
authors.initials: R
authors.lastname: Churm
authors.affiliation: Molecular Neurobiology Research Group, Institute of Life Science 1, Swansea University, Swansea, UK.
authors.forename: J S
authors.initials: JS
authors.lastname: Davies
authors.affiliation: Diabetes Research Group, Institute of Life Science 1, Swansea University, Swansea, UK.
authors.forename: J W
authors.initials: JW
authors.lastname: Stephens
authors.affiliation: Diabetes Research Group, Institute of Life Science 1, Swansea University, Swansea, UK.
authors.forename: S L
authors.initials: SL
authors.lastname: Prior
mesh_terms: D017667:Adipocytes / Q000378:metabolism; D050156:Adipogenesis / Q000502:physiology; D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D054439:Ghrelin / Q000097:blood*; D006801:Humans; D007031:Hypothalamus / Q000378:metabolism; D050356:Lipid Metabolism / Q000502:physiology; D009765:Obesity / Q000097:blood*; D010179:Pancreas / Q000378:metabolism
chemical_list: D054439:Ghrelin
keywords: Ghrelin; obesity; type 2 diabetes