title: Naturally Occurring Fc-Dependent Antibody From HIV-Seronegative Individuals Promotes HIV-Induced IFN-α Production.
abstract: A majority of adults without HIV infection and with a low risk of HIV-exposure have plasma IgG antibodies that enhance the rate and magnitude of HIV-induced interferon alpha (IFN-α) production. Fc-dependent IgG-HIV complexes induce IFN-α rapidly and in high titers in response to HIV concentrations that are too low to otherwise stimulate an effective IFN-α response. IFN-α promoting antibody (IPA) counters HIV-specific inhibition of IFN-α production, and compensates for the inherent delay in IFN-α production common to HIV infection and other viruses. Naturally occurring IPA has the potential to initiate a potent IFN-α response early in the course of HIV mucosal invasion in time to terminate infection prior to the creation of a pool of persistently infected cells. The current study adds IPA as a mediator of an Fc-dependent antiviral state capable of preventing HIV infection.
authors.affiliation: East Bay Institute for Research and Education, Mather, California, USA.
authors.forename: Thomas
authors.initials: T
authors.lastname: Lum
authors.affiliation: East Bay Institute for Research and Education, Mather, California, USA.|Associate Chief of Staff Department of Veterans Affairs Medical Center, Sacramento, California, USA.
authors.forename: Jon A
authors.initials: JA
authors.lastname: Green
mesh_terms: D000328:Adult; D002738:Chloroquine / Q000494:pharmacology; D003713:Dendritic Cells / Q000166:cytology / Q000276:immunology; D060467:Disease Resistance; D005260:Female; D015658:HIV Infections / Q000276:immunology / Q000517:prevention & control* / Q000821:virology; D015497:HIV-1 / Q000187:drug effects / Q000276:immunology; D054884:Host-Pathogen Interactions; D006801:Humans; D056724:Immunity, Humoral; D007113:Immunity, Innate; D007141:Immunoglobulin Fc Fragments / Q000097:blood / Q000494:pharmacology*; D007074:Immunoglobulin G / Q000097:blood / Q000494:pharmacology*; D016898:Interferon-alpha / Q000819:agonists / Q000096:biosynthesis; D008297:Male; D008875:Middle Aged; D061251:Primary Cell Culture; D011485:Protein Binding; D011961:Receptors, Fc / Q000276:immunology / Q000378:metabolism; D013785:Thailand; D014481:United States; D014779:Virus Replication / Q000187:drug effects
chemical_list: D007141:Immunoglobulin Fc Fragments; D007074:Immunoglobulin G; D016898:Interferon-alpha; D011961:Receptors, Fc; D002738:Chloroquine