title: A New Microextraction Technique for the Assay of Alkaloids in Chinese Compound Formula-Based Polyether Sulfone Membrane Fiber Decorated by TiO2 Nanoparticles.
abstract: A new nanocomposite membrane was used to clean up impurities from complex samples and the obvious synergy was obtained in this paper. The nanocomposite membrane was prepared by dispersing TiO2 nanoparticles in chloroform and filled in the pores and lumen of polyether sulfone membrane fiber. The novel microextraction method showed the ideal selective extraction effect for alkaloids in the formulae composed of Rhizoma coptidis and the excellent clean-up efficiency compared with the single membrane method. The optimum extraction conditions were as follows: chloroform as accepted phase; the number of nanocomposite membrane fiber bars, 7; extraction time, 30 min; pH of the sample solution, 10.55; desorption solvent, methanol. The limit of detection for the described alkaloids was estimated at 0.122 μg mL-1. The recovery of the four alkaloids in complex samples ranged from 93.24% to 97.94% with relative standard deviation of <4.99 (n = 5). The validated method had been successfully applied to study the transfer rate of alkaloids in the producing process of Qihuang capsule and the ideal transfer rate of alkaloids was obtained in this paper.
authors.affiliation: Shandong Provincial Key Laboratory of Fine Chemicals, Qilu University of Technology, Jinan 250353, China.
authors.forename: Xinjie
authors.initials: X
authors.lastname: Sun
authors.affiliation: Shandong Provincial Key Laboratory of Fine Chemicals, Qilu University of Technology, Jinan 250353, China.
authors.forename: Yingqin
authors.initials: Y
authors.lastname: Wei
authors.affiliation: Shandong Provincial Key Laboratory of Fine Chemicals, Qilu University of Technology, Jinan 250353, China.
authors.forename: Baojuan
authors.initials: B
authors.lastname: Hou
authors.affiliation: Shandong Provincial Key Laboratory of Fine Chemicals, Qilu University of Technology, Jinan 250353, China.
authors.forename: Guowei
authors.initials: G
authors.lastname: Zhou
mesh_terms: D000470:Alkaloids / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification; D002853:Chromatography, Liquid; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D057230:Limit of Detection; D016014:Linear Models; D008567:Membranes, Artificial; D053758:Nanoparticles / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D015203:Reproducibility of Results; D052617:Solid Phase Microextraction / Q000379:methods*; D013450:Sulfones / Q000737:chemistry*; D014025:Titanium / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D004365:Drugs, Chinese Herbal; D008567:Membranes, Artificial; D011108:Polymers; D013450:Sulfones; C009495:titanium dioxide; C022840:polyether sulfone; D014025:Titanium