title: Does improvement of cognitive functioning by cognitive remediation therapy effect work outcomes in severe mental illness? A secondary analysis of a randomized controlled trial.
abstract: OBJECTIVE
  The aim of this study was to clarify whether improvement of cognitive functioning by cognitive remediation therapy can improve work outcome in schizophrenia and other severe mental illnesses when combined with supported employment.
  
  
  METHODS
  The subjects of this study were persons with severe mental illness diagnosed with schizophrenia, major depression, or bipolar disorder (ICD-10) and cognitive dysfunction who participated in both cognitive remediation using the Thinking Skills for Work program and a supported employment program in a multisite, randomized controlled study. Logistic and multiple linear regression analyses were performed to clarify the influence of cognitive functioning on vocational outcomes, adjusting for demographic and clinical variables.
  
  
  RESULTS
  Improvement of cognitive functioning with cognitive remediation significantly contributed to the total days employed and total earnings of competitive employment in supported employment service during the study period. Any baseline demographic and clinical variables did not significantly contribute to the work-related outcomes.
  
  
  CONCLUSIONS
  A cognitive remediation program transferring learning skills into the real world is useful to increase the quality of working life in supported employment services for persons with severe mental illness and cognitive dysfunction who want to work competitively.
authors.affiliation: Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan.
authors.forename: Emi
authors.initials: E
authors.lastname: Ikebuchi
authors.affiliation: Department of Psychiatric Rehabilitation, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan.
authors.forename: Sayaka
authors.initials: S
authors.lastname: Sato
authors.affiliation: Department of Psychiatric Rehabilitation, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan.
authors.forename: Sosei
authors.initials: S
authors.lastname: Yamaguchi
authors.affiliation: Department of Mental Health/Psychiatric Nursing, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
authors.forename: Michiyo
authors.initials: M
authors.lastname: Shimodaira
authors.affiliation: Department of Psychiatric Rehabilitation, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan.
authors.forename: Ayano
authors.initials: A
authors.lastname: Taneda
authors.affiliation: Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan.
authors.forename: Norifumi
authors.initials: N
authors.lastname: Hatsuse
authors.affiliation: Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan.
authors.forename: Yukako
authors.initials: Y
authors.lastname: Watanabe
authors.affiliation: National Center of Neurology and Psychiatry, National Center Hospital, Tokyo, Japan.
authors.forename: Masuhiro
authors.initials: M
authors.lastname: Sakata
authors.affiliation: National Center of Neurology and Psychiatry, National Center Hospital, Tokyo, Japan.
authors.forename: Naoko
authors.initials: N
authors.lastname: Satake
authors.affiliation: Tohoku Fukushi University School of Welfare, Sendai, Japan.
authors.forename: Masaaki
authors.initials: M
authors.lastname: Nishio
authors.affiliation: ACT-J Team/The Clinic 'Si Puo Fare', Miyagi, Japan.
authors.forename: Jun-Ichiro
authors.initials: JI
authors.lastname: Ito
mesh_terms: D000328:Adult; D001714:Bipolar Disorder / Q000150:complications / Q000523:psychology* / Q000628:therapy*; D003072:Cognition Disorders / Q000150:complications / Q000628:therapy*; D000072466:Cognitive Remediation; D003865:Major Depressive Disorder / Q000150:complications / Q000523:psychology* / Q000628:therapy*; D016832:Employment, Supported / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000150:complications / Q000628:therapy*; D012565:Schizophrenic Psychology; D055815:Young Adult
keywords: cognitive functioning; cognitive remediation; schizophrenia; supported employment; working life