title: Stimulus-induced Epileptic Spike-Wave Discharges in Thalamocortical Model with Disinhibition.
abstract: Epileptic absence seizure characterized by the typical 2-4 Hz spike-wave discharges (SWD) are known to arise due to the physiologically abnormal interactions within the thalamocortical network. By introducing a second inhibitory neuronal population in the cortical system, here we propose a modified thalamocortical field model to mathematically describe the occurrences and transitions of SWD under the mutual functions between cortex and thalamus, as well as the disinhibitory modulations of SWD mediated by the two different inhibitory interneuronal populations. We first show that stimulation can induce the recurrent seizures of SWD in the modified model. Also, we demonstrate the existence of various types of firing states including the SWD. Moreover, we can identify the bistable parametric regions where the SWD can be both induced and terminated by stimulation perturbations applied in the background resting state. Interestingly, in the absence of stimulation disinhibitory functions between the two different interneuronal populations can also both initiate and abate the SWD, which suggests that the mechanism of disinhibition is comparable to the effect of stimulation in initiating and terminating the epileptic SWD. Hopefully, the obtained results can provide theoretical evidences in exploring dynamical mechanism of epileptic seizures.
authors.affiliation: School of Mathematics and Physics, University of Science and Technology Beijing, Beijing 100083, P. R. China.
authors.forename: Denggui
authors.initials: D
authors.lastname: Fan
authors.affiliation: Department of Dynamics and Control, Beihang University, Beijing 100191, P. R. China.
authors.forename: Suyu
authors.initials: S
authors.lastname: Liu
authors.affiliation: Department of Dynamics and Control, Beihang University, Beijing 100191, P. R. China.
authors.forename: Qingyun
authors.initials: Q
authors.lastname: Wang
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D002540:Cerebral Cortex / Q000503:physiopathology*; D004827:Epilepsy / Q000503:physiopathology*; D007696:Kindling, Neurologic; D008959:Models, Neurological; D009433:Neural Inhibition; D009474:Neurons / Q000473:pathology; D013788:Thalamus / Q000503:physiopathology*; D013997:Time Factors