title: Expression of human endogenous retrovirus K and W in babies.
abstract: Here we determined the relative expression of HERV-K and W proviruses in HIV infected and non-infected mothers as well as their respective babies up to 1 year-old. HIV-infected mothers, their babies and uninfected control groups presented expression of both HERV-K and HERV-W with relatively high frequency. While the level of HERV-K expression was similar among groups, the level of HERV-W expression in HIV-infected mothers was four-fold higher than the uninfected mothers from the control group (p < 0.01). HERV-W was down regulated in HIV-exposed babies in comparison to non-exposed babies. To our knowledge, this is the first report of HERV transcriptional activity in babies from 0-1 year-old.
authors.affiliation: Laboratório de Virologia, Instituto de Medicina Tropical de São Paulo, LIM-52 (LIMHC) Universidade de São Paulo, Rua Dr. Enéas de Carvalho Aguiar, 470, São Paulo, 05403-000, Brazil.
authors.forename: L H S
authors.initials: LH
authors.lastname: Nali
authors.affiliation: Laboratório de Virologia, Instituto de Medicina Tropical de São Paulo, LIM-52 (LIMHC) Universidade de São Paulo, Rua Dr. Enéas de Carvalho Aguiar, 470, São Paulo, 05403-000, Brazil.
authors.forename: A C S
authors.initials: AC
authors.lastname: Oliveira
authors.affiliation: Laboratório de Virologia, Instituto de Medicina Tropical de São Paulo, LIM-52 (LIMHC) Universidade de São Paulo, Rua Dr. Enéas de Carvalho Aguiar, 470, São Paulo, 05403-000, Brazil.
authors.forename: D O
authors.initials: DO
authors.lastname: Alves
authors.affiliation: Laboratório de Virologia, Instituto de Medicina Tropical de São Paulo, LIM-52 (LIMHC) Universidade de São Paulo, Rua Dr. Enéas de Carvalho Aguiar, 470, São Paulo, 05403-000, Brazil.
authors.forename: G S
authors.initials: GS
authors.lastname: Caleiro
authors.affiliation: Laboratório de Virologia, Instituto de Medicina Tropical de São Paulo, LIM-52 (LIMHC) Universidade de São Paulo, Rua Dr. Enéas de Carvalho Aguiar, 470, São Paulo, 05403-000, Brazil.
authors.forename: C F
authors.initials: CF
authors.lastname: Nunes
authors.affiliation: Laboratório de Virologia, Instituto de Medicina Tropical de São Paulo, LIM-52 (LIMHC) Universidade de São Paulo, Rua Dr. Enéas de Carvalho Aguiar, 470, São Paulo, 05403-000, Brazil.|Departamento de Pediatria, Universidade Federal de São Paulo, Rua Sena Madureira 1500, São Paulo, 04021-001, Brazil.
authors.forename: D
authors.initials: D
authors.lastname: Gerhardt
authors.affiliation: Departamento de Pediatria, Universidade Federal de São Paulo, Rua Sena Madureira 1500, São Paulo, 04021-001, Brazil.
authors.forename: R C M
authors.initials: RC
authors.lastname: Succi
authors.affiliation: Laboratório de Virologia, Instituto de Medicina Tropical de São Paulo, LIM-52 (LIMHC) Universidade de São Paulo, Rua Dr. Enéas de Carvalho Aguiar, 470, São Paulo, 05403-000, Brazil. cmromano@usp.br.
authors.forename: Camila M
authors.initials: CM
authors.lastname: Romano
authors.affiliation: Laboratório de Virologia, Instituto de Medicina Tropical de São Paulo, LIM-52 (LIMHC) Universidade de São Paulo, Rua Dr. Enéas de Carvalho Aguiar, 470, São Paulo, 05403-000, Brazil.|Departamento de Pediatria, Universidade Federal de São Paulo, Rua Sena Madureira 1500, São Paulo, 04021-001, Brazil.
authors.forename: D M
authors.initials: DM
authors.lastname: Machado
mesh_terms: D000328:Adult; D020077:Endogenous Retroviruses / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D005260:Female; D015658:HIV Infections / Q000635:transmission* / Q000821:virology*; D015497:HIV-1 / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000821:virology*; D018445:Infectious Disease Transmission, Vertical; D008297:Male; D014158:Transcription, Genetic