title: Association testing of vasopressin receptor 1a microsatellite polymorphisms in non-clinical autism spectrum phenotypes.
abstract: Variation in the AVPR1a gene, which codes for a receptor for the neurohormone vasopressin, has been found to relate to autism risk. Interestingly, variation in this gene also relates to differences in social behaviour in non-clinical populations. Variation in this gene may affect expression of AVPR1a receptors in brain areas involved in social behaviour. Here, we tested whether AVPR1a variation was associated with Autism Quotient (AQ) scores, a questionnaire that measures non-clinical manifestations of autism, in a population of 873 healthy university students. The AVPR1a RS1 and RS3 microsatellites were examined, and variants were categorized as "long" or "short". The RS3 long/long genotype was significantly associated with a higher AQ score (i.e., a more autistic-like phenotype) for the combined population and for females only. Further examination showed that this relationship was due to a specific RS3 variant, termed the "target allele", which previous research has linked to reduced altruism and increased marital problems in healthy individuals. We also observed that the relationship between RS3 genotype and AQ score was mainly due to the "attention switching" (the ability to shift attention from one task to another) component of the questionnaire; this ability is commonly impaired in autism spectrum disorders. Overall, our study establishes continuity between the existing AVPR1a research in clinical and non-clinical populations. Our results suggest that vasopressin may exert its effects on social behaviour in part by modulating attentional focus between social and non-social cues. Autism Res 2017, 10: 750-756. © 2016 International Society for Autism Research, Wiley Periodicals, Inc.
authors.affiliation: Department of Biological Sciences, Simon Fraser University, Burnaby, V5A 1S6, Canada.
authors.forename: Tanya L
authors.initials: TL
authors.lastname: Procyshyn
authors.affiliation: Department of Psychology and Centre for Neuroscience, University of Alberta, Edmonton, T6G 2R3, Canada.
authors.forename: Peter L
authors.initials: PL
authors.lastname: Hurd
authors.affiliation: Department of Biological Sciences, Simon Fraser University, Burnaby, V5A 1S6, Canada.
authors.forename: Bernard J
authors.initials: BJ
authors.lastname: Crespi
mesh_terms: D000293:Adolescent; D000067877:Autism Spectrum Disorder / Q000175:diagnosis / Q000235:genetics* / Q000523:psychology; D005260:Female; D005819:Genetic Markers / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics*; D010641:Phenotype; D011110:Polymorphism, Genetic / Q000235:genetics*; D017483:Receptors, Vasopressin / Q000235:genetics*; D012016:Reference Values; D012919:Social Behavior; D055815:Young Adult
chemical_list: C000599871:AVPR1A protein, human; D005819:Genetic Markers; D017483:Receptors, Vasopressin
keywords: attention; autism quotient; autism spectrum; avpr1a; microsatellite analysis; rs1; rs3; vasopressin