title: Relationship between selected DNA polymorphisms and coronary artery disease complications.
abstract: BACKGROUND
  Coronary heart disease (CHD) development is complex in origin, with contributions from well-defined lifestyle and not well-determined genetic risk factors. The aim of this study is to report the relationship between certain SNPs and the risk of cardiovascular (CV) complications in patients with CAD confirmed by coronary angiography.
  
  
  METHODS
  In the present study, 1345 subjects with CHD were included. The median follow-up period was 8.6years. 19 SNPs were investigated for any association with Major Advanced CV Events (MACE), Acute Coronary Syndromes (ACS) and Revascularizations. We modeled the 19 SNPs as a multilocus genetic risk score (GRS19).
  
  
  RESULTS
  During follow-up period, 245 participants died; 114 due to CV causes. A fatal or non-fatal CV event occurred in 882 participants including 214 ACS, 578 revascularizations and 90 strokes. The alleles of the following SNPs: rs1746048 (CXCL12), rs9818870 (MRAS) and rs17114036 (PPAP2B) were associated with a higher risk of MACE and the alleles of SNPs rs1746048 (CXCL12) and rs1122608 (LDLR) were associated with a higher risk of revascularization. The alleles of rs12190287 (MRAS), rs121902287 (TCF21) and rs2259816 (HNF1a) were associated with a higher risk of ACS. Despite the lack of relationship between significant CAD and GRS19, in the top quartile of GRS19 there was significant relationship between GRS19 and combined endpoint, MACE, ACS, and revascularization.
  
  
  CONCLUSIONS
  Conclusions. The SNPs of CXCL12 and LDLR were associated with risk of revascularization and CXCL12, LPA, MRAS, and PPAP2B were associated with the risk of MACE. GRS19 determines CV complications in CAD patients with the highest genetic risk score values.
authors.affiliation: Department of Pharmacology, Medical University of Gdansk, Debowa 23, 80-211 Gdansk, Poland. Electronic address: marwirt@interia.pl.
authors.forename: Marcin
authors.initials: M
authors.lastname: Wirtwein
authors.affiliation: Department of Clinical Sciences, Lund University, Malmö, Sweden.
authors.forename: Olle
authors.initials: O
authors.lastname: Melander
authors.affiliation: Department of Clinical Sciences, Lund University, Malmö, Sweden.
authors.forename: Marketa
authors.initials: M
authors.lastname: Sjőgren
authors.affiliation: Department of Hypertension and Diabetology, Medical University of Gdansk, Debinki 7, 80-211 Gdansk, Poland.
authors.forename: Michal
authors.initials: M
authors.lastname: Hoffmann
authors.affiliation: Department of Hypertension and Diabetology, Medical University of Gdansk, Debinki 7, 80-211 Gdansk, Poland.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Narkiewicz
authors.affiliation: I Department of Cardiology, Medical University of Gdansk, Debinki 7, 80-211 Gdansk, Poland.
authors.forename: Marcin
authors.initials: M
authors.lastname: Gruchala
authors.affiliation: I Department of Cardiology, Medical University of Gdansk, Debinki 7, 80-211 Gdansk, Poland.
authors.forename: Wojciech
authors.initials: W
authors.lastname: Sobiczewski
mesh_terms: D000368:Aged; D015331:Cohort Studies; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000150:complications* / Q000235:genetics* / Q000401:mortality; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011044:Poland; D020641:Polymorphism, Single Nucleotide; D018570:Risk Assessment
keywords: Coronary artery disease; DNA polymorphisms; Hypertension