title: 1H NMR Metabolomic Profiling of Human and Animal Blood Serum Samples.
abstract: Nuclear magnetic resonance (NMR) spectroscopy techniques allow the acquisition of a large amount of data and when combined with multivariate statistical analysis, it is possible to process and interpret the obtained NMR data in accordance with the biological problem being investigated. In this chapter, the search for biologically relevant biomarkers is addressed using NMR spectroscopy-based metabolomics, due to their clinical relevance for either diagnosis or monitoring of diseases and disorders.
authors.affiliation: Chemical Biology Laboratory, Institute of Chemistry, Organic Chemistry Department, State University of Campinas, P. O. Box 6154, 13083-970, Campinas, SP, Brazil.
authors.forename: João G M
authors.initials: JGM
authors.lastname: Pontes
authors.affiliation: Chemical Biology Laboratory, Institute of Chemistry, Organic Chemistry Department, State University of Campinas, P. O. Box 6154, 13083-970, Campinas, SP, Brazil.
authors.forename: Antonio J M
authors.initials: AJM
authors.lastname: Brasil
authors.affiliation: Chemical Biology Laboratory, Institute of Chemistry, Organic Chemistry Department, State University of Campinas, P. O. Box 6154, 13083-970, Campinas, SP, Brazil.
authors.forename: Guilherme C F
authors.initials: GCF
authors.lastname: Cruz
authors.affiliation: Chemical Biology Laboratory, Institute of Chemistry, Organic Chemistry Department, State University of Campinas, P. O. Box 6154, 13083-970, Campinas, SP, Brazil.
authors.forename: Rafael N
authors.initials: RN
authors.lastname: de Souza
authors.affiliation: Chemical Biology Laboratory, Institute of Chemistry, Organic Chemistry Department, State University of Campinas, P. O. Box 6154, 13083-970, Campinas, SP, Brazil. ljubica@iqm.unicamp.br.
authors.forename: Ljubica
authors.initials: L
authors.lastname: Tasic
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood*; D006801:Humans; D055442:Metabolome; D055432:Metabolomics / Q000379:methods; D066244:Proton Magnetic Resonance Spectroscopy / Q000379:methods; D012984:Software; D057188:Workflow
chemical_list: D015415:Biomarkers
keywords: Biomarkers; Chemometrics; Metabolomics; Nuclear Magnetic Resonance; Serum