title: Infant food applications of complex carbohydrates: Structure, synthesis, and function.
abstract: Professional health bodies such as the World Health Organization (WHO), the American Academy of Pediatrics (AAP), and the U.S. Department of Health and Human Services (HHS) recommend breast milk as the sole source of food during the first year of life. This position recognizes human milk as being uniquely suited for infant nutrition. Nonetheless, most neonates in the West are fed alternatives by 6 months of age. Although inferior to human milk in most aspects, infant formulas are able to promote effective growth and development. However, while breast-fed infants feature a microbiota dominated by bifidobacteria, the bacterial flora of formula-fed infants is usually heterogeneous with comparatively lower levels of bifidobacteria. Thus, the objective of any infant food manufacturer is to prepare a product that results in a formula-fed infant developing a breast-fed infant-like microbiota. The goal of this focused review is to discuss the structure, synthesis, and function of carbohydrate additives that play a role in governing the composition of the infant microbiome and have other health benefits.
authors.affiliation: Department of Chemistry, Vanderbilt University, Nashville, TN 37235, United States.
authors.forename: Dorothy L
authors.initials: DL
authors.lastname: Ackerman
authors.affiliation: Department of Chemistry, Vanderbilt University, Nashville, TN 37235, United States.
authors.forename: Kelly M
authors.initials: KM
authors.lastname: Craft
authors.affiliation: Department of Chemistry, Vanderbilt University, Nashville, TN 37235, United States; Institute of Chemical Biology, Vanderbilt University, Nashville, TN 37232, United States. Electronic address: steven.d.townsend@vanderbilt.edu.
authors.forename: Steven D
authors.initials: SD
authors.lastname: Townsend
mesh_terms: D001644:Bifidobacterium; D050260:Carbohydrate Metabolism; D002241:Carbohydrates / Q000138:chemical synthesis / Q000737:chemistry*; D005630:Fructans / Q000737:chemistry / Q000378:metabolism; D000069196:Gastrointestinal Microbiome; D006801:Humans; D007223:Infant; D041943:Infant Formula / Q000737:chemistry*; D007785:Lactose / Q000737:chemistry / Q000378:metabolism; D008895:Milk, Human / Q000737:chemistry; D009844:Oligosaccharides / Q000737:chemistry / Q000378:metabolism; D011134:Polysaccharides / Q000737:chemistry / Q000378:metabolism; D056692:Prebiotics
chemical_list: D002241:Carbohydrates; D005630:Fructans; D009844:Oligosaccharides; D011134:Polysaccharides; D056692:Prebiotics; C007916:hemicellulose; D007785:Lactose
keywords: Carrageenans; Cellulose; Fructan; Fructooligosaccharide; Galactomannans; Galactooligosaccharide; Hemicellulose; Inulin; Lactitol; Lactose; Lactulose; Levan; Polydextrose; Xylooligosacharide