title: Antimutagenic Effect of Afobazole on Blood Leukocytes in Individuals with Reproductive Dysfunction under Conditions of Anthropogenic Load.
abstract: Increased frequency of cells with chromosomal aberrations was revealed in 48-h cultures of peripheral blood lymphocytes isolated North Ossetia residents with impaired reproductive function. After 2-week treatment with antimutagenic drug Afobazole, the percentage of cells with chromosomal aberrations significantly decreased from 3.77±0.20 to 2.48±0.24% (p<0.001). Significant differences between chromosome damage levels before and after administration of the drug suggest that Afobazole could be recommended for protective purposes to this group of patients.
authors.affiliation: Clinical Hospital of the North Ossetian Medical Academy, Vladikavkaz, Republic of North Ossetia-Alania, Russia. fa-2009@yandex.ru.
authors.forename: F T
authors.initials: FT
authors.lastname: Chshieva
mesh_terms: D000328:Adult; D016587:Antimutagenic Agents / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000627:therapeutic use*; D016022:Case-Control Studies; D002869:Chromosome Aberrations; D020732:Cytogenetic Analysis; D004334:Drug Administration Schedule; D004781:Environmental Exposure / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000188:drug therapy* / Q000209:etiology / Q000235:genetics / Q000473:pathology; D007248:Infertility, Male / Q000188:drug therapy* / Q000209:etiology / Q000235:genetics / Q000473:pathology; D007963:Leukocytes, Mononuclear / Q000378:metabolism / Q000473:pathology; D008297:Male; D008677:Metaphase; D009025:Morpholines / Q000627:therapeutic use*; D016296:Mutagenesis; D016896:Treatment Outcome
chemical_list: C410924:2-((2-morpholino)ethylthio)-5-ethoxybenzimidazole; D016587:Antimutagenic Agents; D001562:Benzimidazoles; D009025:Morpholines
keywords: Afobazole; chromosomal aberrations; reproductive system