title: A dividing matter: Drp1/Dnm1-independent mitophagy.
abstract: Whether or not mitophagy depends on prior mitochondrial fragmentation by the canonical mitochondrial division machinery is controversial. In this issue, Yamashita et al. (2016. J. Cell Biol. https://doi.org/10.1083/jcb.201605093) report that mitochondrial fragments start to bud and divide from mitochondrial tubules when in tight association with forming autophagosomes, but independently of the mitochondrial division factor Drp1/Dnm1.
authors.affiliation: Max Planck Institute for Biology of Ageing, 50931 Cologne, Germany martin.graef@age.mpg.de.|Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases, University of Cologne, 50931 Cologne, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Graef
mesh_terms: D034281:Dynamins / Q000378:metabolism*; D006367:HeLa Cells; D006801:Humans; D008928:Mitochondria / Q000378:metabolism; D063306:Mitophagy; D008954:Models, Biological; D010843:Pichia / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism
chemical_list: D044767:Ubiquitin-Protein Ligases; C111567:parkin protein; D034281:Dynamins