title: Treatment of prurigo nodularis with lenalidomide.
abstract: Prurigo nodularis (PN) is an intensely pruriginous dermatological disorder whose treatment is challenging for dermatologists. It is characterized by eruptions of papules and hyperkeratotic nodules, some of which are eroded, on the extensor surfaces of the limbs. The most commonly used treatments for this condition are oral antihistamines and topical or systemic steroids. Thalidomide is an effective treatment option in cases of recalcitrant PN; however, its most frequent adverse effect is neurotoxicity, which often results in its discontinuation. Lenalidomide is an analogue of thalidomide that is more powerful and associated with less neurotoxicity than thalidomide. We report the third case of PN treated with lenalidomide, which involved a patient who was refractory to thalidomide. Lenalidomide may be a more effective treatment for PN than thalidomide and has a more favorable side effects profile than its counterpart.
authors.affiliation: Unidad de Gestión Clínica de Dermatología, Hospital Universitario Puerta del Mar, Cádiz, Spain.
authors.forename: Lidia
authors.initials: L
authors.lastname: Ossorio-García
authors.affiliation: Unidad de Gestión Clínica de Dermatología, Hospital Universitario Puerta del Mar, Cádiz, Spain.
authors.forename: David
authors.initials: D
authors.lastname: Jiménez-Gallo
authors.affiliation: Unidad de Gestión Clínica de Farmacia Hospitalaria, Hospital Universitario Puerta del Mar, Cádiz, Spain.
authors.forename: María Eugenia
authors.initials: ME
authors.lastname: Rodríguez-Mateos
authors.affiliation: Unidad de Gestión Clínica de Dermatología, Hospital Universitario Puerta del Mar, Cádiz, Spain.
authors.forename: Cintia
authors.initials: C
authors.lastname: Arjona-Aguilera
authors.affiliation: Unidad de Gestión Clínica de Dermatología, Hospital Universitario Puerta del Mar, Cádiz, Spain.
authors.forename: Mario
authors.initials: M
authors.lastname: Linares-Barrios
mesh_terms: D005260:Female; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use*; D000077269:Lenalidomide; D008875:Middle Aged; D011536:Prurigo / Q000175:diagnosis / Q000188:drug therapy*; D012074:Remission Induction; D013792:Thalidomide / Q000031:analogs & derivatives* / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D007155:Immunologic Factors; D013792:Thalidomide; D000077269:Lenalidomide
keywords: inflammatory disorders; pruritus; therapy-systemic