title: Genetic predisposition to leukemia and other hematologic malignancies.
abstract: In this review, we provide an overview of familial myelodysplastic syndromes (MDS)/acute leukemia (AL) and bone marrow failure syndromes, as well as insights into familial myeloproliferative neoplasms (MPNs), familial multiple myeloma (MM), familial Waldenström macroglobulinemia (WM), familial lymphoma, and cancer predisposition syndromes with increased risk of MDS/AL. This field will continue to accelerate as next-generation sequencing (NGS) techniques identify novel predisposition alleles in families with a genetic predisposition to hematologic malignancies. Newly identified predisposition genes continue to inform the field of inherited leukemia and other hematologic malignancies. Current developments in clinical translation include techniques detailing the acquisition of appropriate germline material for patient work-ups, methods for genetic testing, and nuances essential for the treatment and clinical management of patients with a genetic predisposition to hematologic malignancies.
authors.affiliation: Section of Hematology/Oncology, Department of Medicine, The Center for Clinical Cancer Genetics, and The University of Chicago Comprehensive Cancer Center, The University of Chicago, Chicago, IL, USA; Klinik für Innere Medizin III, Abteilung Hämatologie und Onkologie, Universitätsklinikum Ulm, Germany.
authors.forename: Simone
authors.initials: S
authors.lastname: Feurstein
authors.affiliation: Section of Hematology/Oncology, Department of Medicine, The Center for Clinical Cancer Genetics, and The University of Chicago Comprehensive Cancer Center, The University of Chicago, Chicago, IL, USA.
authors.forename: Michael W
authors.initials: MW
authors.lastname: Drazer
authors.affiliation: Section of Hematology/Oncology, Department of Medicine, The Center for Clinical Cancer Genetics, and The University of Chicago Comprehensive Cancer Center, The University of Chicago, Chicago, IL, USA. Electronic address: lgodley@medicine.bsd.uchicago.edu.
authors.forename: Lucy A
authors.initials: LA
authors.lastname: Godley
mesh_terms: D020022:Genetic Predisposition to Disease; D006801:Humans; D007938:Leukemia / Q000209:etiology / Q000235:genetics* / Q000628:therapy; D008223:Lymphoma / Q000209:etiology / Q000235:genetics*; D009190:Myelodysplastic Syndromes / Q000209:etiology / Q000235:genetics
keywords: Familial leukemia; Genetic risk