title: IncP Plasmid Carrying Colistin Resistance Gene mcr-1 in Klebsiella pneumoniae from Hospital Sewage.
abstract: A Klebsiella pneumoniae strain of sequence type 313 (ST313) recovered from hospital sewage was found carrying the plasmid-borne colistin resistance gene mcr-1, which was bracketed by two copies of the insertion sequence ISApl1 on a 57-kb self-transmissible IncP-type plasmid of a new IncP-1 clade. The carriage of mcr-1 on a self-transmissible broad-host-range plasmid highlights that mcr-1 has the potential to spread beyond the Enterobacteriaceae family.
authors.affiliation: Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China.|Division of Infectious Diseases, State Key Laboratory of Biotherapy, Chengdu, China.
authors.forename: Feifei
authors.initials: F
authors.lastname: Zhao
authors.affiliation: Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China.|Division of Infectious Diseases, State Key Laboratory of Biotherapy, Chengdu, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Feng
authors.affiliation: Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China.|Division of Infectious Diseases, State Key Laboratory of Biotherapy, Chengdu, China.
authors.forename: Xiaoju
authors.initials: X
authors.lastname: Lü
authors.affiliation: Institute of Microbiology and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom.
authors.forename: Alan
authors.initials: A
authors.lastname: McNally
authors.affiliation: Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China zongzhiy@scu.edu.cn.|Division of Infectious Diseases, State Key Laboratory of Biotherapy, Chengdu, China.|Department of Infection Control, West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Zong
mesh_terms: D003091:Colistin / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial / Q000235:genetics; D006761:Hospitals; D007711:Klebsiella pneumoniae / Q000187:drug effects* / Q000235:genetics*; D010957:Plasmids / Q000235:genetics*; D012722:Sewage / Q000382:microbiology
chemical_list: D012722:Sewage; D003091:Colistin
keywords: Klebsiella pneumoniae; colistin resistance; mcr-1; sewage