title: Approach to osteomyelitis treatment with antibiotic loaded PMMA.
abstract: BACKGROUND
  To reduce the incidence of osteomyelitis infection, local antibiotic impregnated delivery systems are commonly used as a promising and effective approach to deliver high antibiotic concentrations at the infection site.
  
  
  OBJECTIVE
  The objective of this review was to provide a literature review regarding approach to osteomyelitis treatment with antibiotic loaded PMMA.
  
  
  METHODS
  Literature study regarding osteomyelitis treatment with antibiotic loaded carriers using key terms Antibiotic, osteomyelitis, biodegradable PMMA through published articles. Hands searching of bibliographies of identified articles were also undertaken.
  
  
  CONCLUSIONS
  We concluded that Antibiotic-impregnated PMMA beads are useful options for the treatment of osteomyelitis for prolonged drug therapy.
authors.affiliation: Department of Orthopedics, Hong Hui Hospital, Xi'an Jiaotong University College of Medicine, Shaanxi 710054, China.
authors.forename: Zhang
authors.initials: Z
authors.lastname: Wentao
authors.affiliation: Department of Orthopedics, Weinan Central Hospital, Shaanxi 710054, China.
authors.forename: Guangyu
authors.initials: G
authors.lastname: Lei
authors.affiliation: Department of Orthopedics, Hong Hui Hospital, Xi'an Jiaotong University College of Medicine, Shaanxi 710054, China. Electronic address: erica.star80@gmail.com.
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Orthopedics, Weinan Central Hospital, Shaanxi 710054, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.affiliation: Department of Orthopedics, Hong Hui Hospital, Xi'an Jiaotong University College of Medicine, Shaanxi 710054, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Song
authors.affiliation: Department of Orthopedics, Hong Hui Hospital, Xi'an Jiaotong University College of Medicine, Shaanxi 710054, China.
authors.forename: Jinzhu
authors.initials: J
authors.lastname: Fan
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D001706:Biopsy; D004195:Disease Models, Animal; D004337:Drug Carriers; D016503:Drug Delivery Systems; D065546:Drug Liberation; D016903:Drug Monitoring; D006801:Humans; D010019:Osteomyelitis / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology*; D019904:Polymethyl Methacrylate; D011859:Radiography; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D004337:Drug Carriers; D019904:Polymethyl Methacrylate
keywords: Antibiotic; Biodegradable PMMA; Infection; Osteomyelitis