title: Endomorphins and β-Endorphin Do Not Affect Heart Tolerance to the Pathogenic Effect of Reperfusion.
abstract: Selective agonists of μ1- and μ2-opioid receptors endomorphin-2 and endomorphin-1 injected intravenously in a dose of 4500 nmol/kg in 5 min before coronary blood flow resumption had no effect on cardiac reperfusion damage. Consequently, μ1- and μ2-opioid receptors are not involved in the regulation of heart tolerance to reperfusion injury. Nonselective opioid receptor agonist β-endorphin (100 nmol/kg) also did not affect heart tolerance to the pathogenic effect of reperfusion.
authors.affiliation: Research Institute of Cardiology, Tomsk, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Mukhomedzyanov
authors.affiliation: Research Institute of Cardiology, Tomsk, Russia. maslov@cardio-tomsk.ru.
authors.forename: L N
authors.initials: LN
authors.lastname: Maslov
authors.affiliation: Research Institute of Cardiology, Tomsk, Russia.
authors.forename: S Yu
authors.initials: SY
authors.lastname: Tsibulnikov
authors.affiliation: Fourth Military Medical University, Xi'an, Shaanxi Province, China.
authors.forename: J M
authors.initials: JM
authors.lastname: Pei
mesh_terms: D000701:Analgesics, Opioid / Q000494:pharmacology*; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000378:metabolism* / Q000503:physiopathology; D001794:Blood Pressure / Q000187:drug effects; D054059:Coronary Occlusion; D003331:Coronary Vessels / Q000601:surgery; D057775:Ischemic Postconditioning; D008297:Male; D015428:Myocardial Reperfusion Injury / Q000378:metabolism* / Q000503:physiopathology; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D009842:Oligopeptides / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D017450:Receptors, Opioid, mu / Q000819:agonists / Q000378:metabolism; D001615:beta-Endorphin / Q000494:pharmacology*
chemical_list: D000701:Analgesics, Opioid; D009842:Oligopeptides; D017450:Receptors, Opioid, mu; C105293:endomorphin 1; C105294:endomorphin 2; D001615:beta-Endorphin
keywords: arrhythmias; heart; myocardial infarction; opioids; postconditioning