title: 2-Morpholino-5-Phenyl-6H-1,3,4-Thiadiazine Corrects Metabolic Disorders during the Development of Alloxan Diabetes Mellitus in Rats.
abstract: Metabolic disorders were evaluated in rats with alloxan diabetes mellitus after administration of 2-morpholino-5-phenyl-6H-1,3,4-thiadiazine (compound L-17). Administration of L-17 reduced the severity of metabolic disorders associated with diabetes mellitus. At the end of the experiment, the concentration of glucose, glycated hemoglobin, malonic dialdehyde, and catalase activity were significantly higher and peroxidase activity was significantly lower in the group of animals receiving L-17. The decrease of glycemia, glucose concentration, and glycated hemoglobin content was reached by the 3rd-4th week of the experiment. These data suggest that correction of biochemical parameters in rats with alloxan diabetes was reached after administration of L-17 for at least 3 weeks.
authors.affiliation: B. N. Yeltsin Ural Federal University, Ekaterinburg, Russia. evvd@list.ru.
authors.forename: V V
authors.initials: VV
authors.lastname: Emelianov
authors.affiliation: B. N. Yeltsin Ural Federal University, Ekaterinburg, Russia.
authors.forename: E A
authors.initials: EA
authors.lastname: Savateeva
authors.affiliation: B. N. Yeltsin Ural Federal University, Ekaterinburg, Russia.
authors.forename: L P
authors.initials: LP
authors.lastname: Sidorova
authors.affiliation: B. N. Yeltsin Ural Federal University, Ekaterinburg, Russia.
authors.forename: T A
authors.initials: TA
authors.lastname: Tseitler
authors.affiliation: Institute of Immunology and Physiology, Ural Division of the Russian Academy of Sciences, Ekaterinburg, Russia.
authors.forename: I F
authors.initials: IF
authors.lastname: Gette
authors.affiliation: Institute of Immunology and Physiology, Ural Division of the Russian Academy of Sciences, Ekaterinburg, Russia.
authors.forename: T S
authors.initials: TS
authors.lastname: Bulavintseva
authors.affiliation: Institute of Immunology and Physiology, Ural Division of the Russian Academy of Sciences, Ekaterinburg, Russia.
authors.forename: S E
authors.initials: SE
authors.lastname: Smirnykh
authors.affiliation: B. N. Yeltsin Ural Federal University, Ekaterinburg, Russia.
authors.forename: N E
authors.initials: NE
authors.lastname: Maksimova
authors.affiliation: B. N. Yeltsin Ural Federal University, Ekaterinburg, Russia.
authors.forename: N N
authors.initials: NN
authors.lastname: Mochulskaya
authors.affiliation: B. N. Yeltsin Ural Federal University, Ekaterinburg, Russia.
authors.forename: O N
authors.initials: ON
authors.lastname: Chupakhin
authors.affiliation: B. N. Yeltsin Ural Federal University, Ekaterinburg, Russia.|Institute of Immunology and Physiology, Ural Division of the Russian Academy of Sciences, Ekaterinburg, Russia.
authors.forename: V A
authors.initials: VA
authors.lastname: Chereshnev
mesh_terms: D000496:Alloxan; D000818:Animals; D021461:Animals, Outbred Strains; D001786:Blood Glucose / Q000378:metabolism; D002374:Catalase / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000097:blood* / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology; D006442:Glycated Hemoglobin / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D007273:Injections, Intramuscular; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D009025:Morpholines / Q000494:pharmacology*; D009195:Peroxidase / Q000097:blood; D051381:Rats; D013829:Thiadiazines / Q000494:pharmacology*
chemical_list: D000496:Alloxan; D001786:Blood Glucose; D002374:Catalase; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D008315:Malondialdehyde; D009025:Morpholines; D009195:Peroxidase; D013829:Thiadiazines; C508297:2-morpholino-5-phenyl-1,3,4-thiadiazine
keywords: 1,3,4-thiadiazines; diabetes mellitus; oxidative stress; protein glycation