title: Antipsychotic drug exposure and risk of myocardial infarction.
abstract: Patients experiencing psychoses and in need of antipsychotic agents may be exposed to a higher risk of myocardial infarction (MI) than the general population. As there have been no randomised studies investigating this association, a recent systematic review and meta-analysis included all observational studies that compared the incidence of MI among patients receiving antipsychotics v. no treatment. It found nine studies and calculated that the odds (risk) for developing MI were 1.88-fold higher in antipsychotic users compared with individuals who had not taken antipsychotic drugs. In this commentary, the results of this systematic review are discussed in view of their clinical implications for everyday clinical practice.
authors.affiliation: Department of Neuroscience, Biomedicine and Movement Sciences,Section of Psychiatry,University of Verona,Verona,Italy.
authors.forename: C
authors.initials: C
authors.lastname: Barbui
authors.affiliation: Department of Neuroscience, Biomedicine and Movement Sciences,Section of Psychiatry,University of Verona,Verona,Italy.
authors.forename: C
authors.initials: C
authors.lastname: Gastaldon
authors.affiliation: Department of Neuroscience, Biomedicine and Movement Sciences,Section of Psychiatry,University of Verona,Verona,Italy.
authors.forename: D
authors.initials: D
authors.lastname: Papola
authors.affiliation: Department of Neuroscience, Biomedicine and Movement Sciences,Section of Psychiatry,University of Verona,Verona,Italy.
authors.forename: G
authors.initials: G
authors.lastname: Ostuzzi
mesh_terms: D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D015994:Incidence; D009203:Myocardial Infarction / Q000139:chemically induced*; D011600:Psychopharmacology; D011618:Psychotic Disorders; D012307:Risk Factors
chemical_list: D014150:Antipsychotic Agents
keywords: Antipsychotics; myocardial infarction; observational studies; psychosis; systematic reviews