title: Relationship of hemoxygenase-1 and prolidase enzyme activity with oxidative stress in papillary thyroid cancer.
abstract: OBJECTIVE
  Recent studies associate thyroid cancer with oxidative stress. We aim to clarify the relation between papillary thyroid cancer, oxidative stress, hemoxygenase-1, prolidase enzymes and investigate the availability of these enzymes as markers for diagnosis, success of treatment, and follow-up.
  
  
  METHODS
  Thirty-one patients with papillary thyroid carcinoma and 25 healthy control subjects were included in this study. Hemoxygenase-1, prolidase (oxidant stress indicator), malondialdehyde, protein carbonyl, and superoxide dismutase (an indicator of antioxidant defense system) were measured pre-operatively and 30 days after thyroidectomy.
  
  
  RESULTS
  There was a significant decrease in serum levels of malondialdehyde and superoxide dismutase (p <0.001 for both) after thyroidectomy in papillary thyroid carcinoma group. In addition, there was a significant difference in the postoperative serum levels of prolidase, malondialdehyde, protein carbonyl, and superoxide dismutase between papillary thyroid carcinoma and control groups (p =0.024, p <0.001, p =0.002, and p =0.016, respectively) beside significant difference of malondialdehyde, protein carbonyl, hemoxygenase-1, and superoxide dismutase pre-operative serum levels (p <0.001, p =0.003, p =0.006, and p =0.025, respectively).
  
  
  CONCLUSIONS
  When the unquestionable role of oxidative stress in the pathogenesis of cancer is considered, in the future it is expected to associate parametric changes in the serum of patients caused by oxidative stress to papillary thyroid cancer. Hippokratia 2016, 20(1): 55-59.
authors.affiliation: Department of Medical Biochemistry, Cerrahpaşa Medical Faculty, Istanbul University, Istanbul, , Turkey.
authors.forename: D
authors.initials: D
authors.lastname: Terzioglu
authors.affiliation: Department of General Surgery, Cerrahpaşa Medical Faculty, Istanbul University, Istanbul, , Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Teksoz
authors.affiliation: Department of General Surgery, Cerrahpaşa Medical Faculty, Istanbul University, Istanbul, , Turkey.
authors.forename: A E
authors.initials: AE
authors.lastname: Arikan
authors.affiliation: Department of Medical Biochemistry, Cerrahpaşa Medical Faculty, Istanbul University, Istanbul, , Turkey.
authors.forename: E
authors.initials: E
authors.lastname: Uslu
authors.affiliation: Department of Organ Transplantation, HLA Laboratory, Cerrahpaşa Medical Faculty, Istanbul University, Istanbul, , Turkey.
authors.forename: E
authors.initials: E
authors.lastname: Yılmaz
authors.affiliation: Council of Forensic Medicine of Turkey, Bursa Morgue Department, Bursa, Turkey.
authors.forename: B
authors.initials: B
authors.lastname: Eren
keywords: Thyroid cancer; antioxidants; malondialdehyde; protein carbonyl; superoxide dismutase