title: a-Glucosidase inhibitors extracted from the roots of Polygonum multiflorum Thunb.
abstract: A novel stilbene glucoside, polygonumnolide D (1), and a novel dianthrone glycoside, polygonumnolide E (2), were isolated from a 70% EtOH extract of the dried roots of Polygonum multiflorum Thunb., together with six known compounds (3-8). Their structures were elucidated by 1D and 2D NMR as well as mass spectroscopy data. The isolated compounds were evaluated for their a-glucosidase inhibitory activities in vitro. Compounds 1, 2 and 5 showed the inhibitory activity against a-glucosidase with the IC50values of 2.4, 2.7 and 0.3μM, respectively.
authors.affiliation: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.
authors.forename: Jian-Bo
authors.initials: JB
authors.lastname: Yang
authors.affiliation: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.
authors.forename: Jin-Ying
authors.initials: JY
authors.lastname: Tian
authors.affiliation: Research and Inspection Center of Traditional Chinese Medicine and Ethnomedicine, National Institutes for Food and Drug Control, State Food and Drug Administration, Beijing 100050, People's Republic of China.
authors.forename: Zhong
authors.initials: Z
authors.lastname: Dai
authors.affiliation: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.
authors.forename: Fei
authors.initials: F
authors.lastname: Ye
authors.affiliation: Research and Inspection Center of Traditional Chinese Medicine and Ethnomedicine, National Institutes for Food and Drug Control, State Food and Drug Administration, Beijing 100050, People's Republic of China. Electronic address: masc@nifdc.org.cn.
authors.forename: Shuang-Cheng
authors.initials: SC
authors.lastname: Ma
authors.affiliation: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China. Electronic address: wangaiguo@imm.ac.cn.
authors.forename: Ai-Guo
authors.initials: AG
authors.lastname: Wang
mesh_terms: D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification; D000068676:Fallopia multiflora / Q000737:chemistry*; D005959:Glucosidases / Q000037:antagonists & inhibitors*; D005960:Glucosides / Q000737:chemistry* / Q000302:isolation & purification; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D013267:Stilbenes / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: D004791:Enzyme Inhibitors; D005960:Glucosides; D006027:Glycosides; D010936:Plant Extracts; D013267:Stilbenes; C000614775:polygonumnolide D; C000614776:polygonumnolide E; D005959:Glucosidases
keywords: Dianthrone glycoside; Polygonum multiflorum Thunb.; Polygonumnolide D; Polygonumnolide E; Stilbene glucoside; a-Glucosidase inhibition