title: IL1A rs1800587 associates with chronic noncrisis pain in sickle cell disease.
abstract: OBJECTIVE
  Pain is prevalent in sickle cell disease (SCD) patients who display great heterogeneity in pain severity and frequency. Hypothesizing that inflammatory factors are involved in the pathogenesis of SCD pain, we focused on the IL1A C/T polymorphism rs1800587 that is an SNP located in a cis-transcriptional regulatory region.
  
  
  METHODS
  We genotyped IL1A rs1800587 and performed association studies with phenotype data obtained by a multidimensional pain assessment tool using the PAINReportIt®Questionnaire.
  
  
  RESULTS
  Each T allele was associated with a 3.9 increase in composite pain index score (p = 0.04) as determined by multiple linear regression.
  
  
  CONCLUSIONS
  IL1A rs1800587 may influence chronic pain in SCD.
authors.affiliation: Department of Biopharmaceutical Sciences, University of Illinois at Chicago College of Pharmacy, Chicago, IL, USA.
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Hu
authors.affiliation: Department of Biopharmaceutical Sciences, University of Illinois at Chicago College of Pharmacy, Chicago, IL, USA.
authors.forename: Ellie H
authors.initials: EH
authors.lastname: Jhun
authors.affiliation: Department of Biobehavioral Health Science, University of Illinois at Chicago College of Nursing, Chicago, IL, USA.|Department of Biobehavioral Nursing Science, University of Florida College of Nursing, Gainesville, FL, USA.
authors.forename: Yingwei
authors.initials: Y
authors.lastname: Yao
authors.affiliation: Department of Biopharmaceutical Sciences, University of Illinois at Chicago College of Pharmacy, Chicago, IL, USA.|Comprehensive Sickle Cell Center, University of Illinois at Chicago, IL, USA.
authors.forename: Ying
authors.initials: Y
authors.lastname: He
authors.affiliation: Department of Biopharmaceutical Sciences, University of Illinois at Chicago College of Pharmacy, Chicago, IL, USA.|Comprehensive Sickle Cell Center, University of Illinois at Chicago, IL, USA.|Jesse Brown Veteran's Administration Medical Center, Chicago, IL, USA.|Division of Hematology/Oncology, University of Illinois at Chicago College of Medicine, Chicago, IL, USA.
authors.forename: Robert E
authors.initials: RE
authors.lastname: Molokie
authors.affiliation: Department of Biobehavioral Health Science, University of Illinois at Chicago College of Nursing, Chicago, IL, USA.|Department of Biobehavioral Nursing Science, University of Florida College of Nursing, Gainesville, FL, USA.|Comprehensive Sickle Cell Center, University of Illinois at Chicago, IL, USA.
authors.forename: Diana J
authors.initials: DJ
authors.lastname: Wilkie
authors.affiliation: Department of Biopharmaceutical Sciences, University of Illinois at Chicago College of Pharmacy, Chicago, IL, USA.|Comprehensive Sickle Cell Center, University of Illinois at Chicago, IL, USA.
authors.forename: Zaijie J
authors.initials: ZJ
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000755:Anemia, Sickle Cell / Q000235:genetics*; D059350:Chronic Pain / Q000235:genetics*; D005260:Female; D006801:Humans; D053582:Interleukin-1alpha / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D020641:Polymorphism, Single Nucleotide
chemical_list: C508584:IL1A protein, human; D053582:Interleukin-1alpha
keywords: chronic; inflammation; interleukin; pain; pain crisis; polymorphism; promoter; sickle cell; transcription