title: Dihydroavenanthramide D inhibits mast cell degranulation and exhibits anti-inflammatory effects through the activation of neurokinin-1 receptor.
abstract: Chronic pruritus is difficult to treat. Current treatment options are frequently ineffective and new therapeutic approaches are urgently needed. Avenanthramides are active substances in oats that exhibit anti-inflammatory effects. Their potential to interrupt pruritus mechanisms was investigated in this study. It was found that the synthetic analog dihydroavenanthramide D (DHAvD) can interact with the neurokinin-1 receptor (NK1R) and inhibit mast cell degranulation. DHAvD also affects inflammatory processes and reduces secretion of the cytokine interleukin-6. Our findings indicate that DHAvD may act as a NK1R inhibitor and could be a promising candidate for topical treatments of chronic pruritus.
authors.affiliation: Department of Dermatology, University of Münster, Münster, Germany.|Department of Dermatology, Center for Chronic Pruritus, University Hospital Münster, Münster, Germany.
authors.forename: Tobias
authors.initials: T
authors.lastname: Lotts
authors.affiliation: Department of Dermatology, University of Münster, Münster, Germany.|Department of Dermatology, Center for Chronic Pruritus, University Hospital Münster, Münster, Germany.
authors.forename: Konstantin
authors.initials: K
authors.lastname: Agelopoulos
authors.affiliation: Department of Dermatology, University of Münster, Münster, Germany.|Department of Dermatology, Center for Chronic Pruritus, University Hospital Münster, Münster, Germany.
authors.forename: Ngoc Q
authors.initials: NQ
authors.lastname: Phan
authors.affiliation: Department of Dermatology, University of Münster, Münster, Germany.|Department of Dermatology, Experimental Dermatology and Immunobiology of the Skin, University Hospital Münster, Münster, Germany.
authors.forename: Karin
authors.initials: K
authors.lastname: Loser
authors.affiliation: Symrise AG, Holzminden, Germany.
authors.forename: Gerhard
authors.initials: G
authors.lastname: Schmaus
authors.affiliation: Department of Dermatology, University of Münster, Münster, Germany.
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Luger
authors.affiliation: Department of Dermatology, University of Münster, Münster, Germany.|Department of Dermatology, Center for Chronic Pruritus, University Hospital Münster, Münster, Germany.
authors.forename: Sonja
authors.initials: S
authors.lastname: Ständer
mesh_terms: D000818:Animals; D020013:Calcium Signaling / Q000187:drug effects; D002460:Cell Line; D002908:Chronic Disease; D004353:Drug Evaluation, Preclinical; D006801:Humans; D008407:Mast Cells / Q000187:drug effects*; D011537:Pruritus / Q000188:drug therapy*; D051381:Rats; D018040:Receptors, Neurokinin-1 / Q000378:metabolism*; D013373:Substance P; D062367:ortho-Aminobenzoates / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D018040:Receptors, Neurokinin-1; D062367:ortho-Aminobenzoates; C532345:dihydroavenanthramide D; D013373:Substance P
keywords: chronic pruritus; interleukin-6; neurokinin-1 receptor antagonist; substance P