title: Ultrafast optical property map generation using lookup tables.
abstract: Imaging technologies working in the spatial frequency domain are becoming increasingly popular for generating wide-field maps of optical properties, enabling rapid analysis of tissue parameters. While acquisition methods have become faster and are now performing in real-time, processing methods remain slow, precluding real-time display of information. We present solutions that rapidly solve the inverse problem for extracting optical properties by use of advanced lookup tables (LUTs). We present methods and results based on a dense, linearly sampled lookup table and an analytical representation that generate maps of absorption and reduced scattering in ?10??ms, which is 100× faster than the standard method, with ?4% error compared to the Monte-Carlo simulation. Combined with real-time acquisition methods, the proposed techniques enable video-rate feedback of real-time property maps, enabling full video-rate guidance in the clinic.
authors.affiliation: Beth Israel Deaconess Medical Center, Department of Medicine, 330 Brookline Avenue, Boston, Massachusetts 02215, United StatesbBoston University, Department of Biomedical Engineering, 44 Cummington Mall, Boston, Massachusetts 02215, United States.
authors.forename: Joseph
authors.initials: J
authors.lastname: Angelo
authors.affiliation: Beth Israel Deaconess Medical Center, Department of Surgery, 330 Brookline Avenue, Boston, Massachusetts 02215, United States.
authors.forename: Christina R
authors.initials: CR
authors.lastname: Vargas
authors.affiliation: Beth Israel Deaconess Medical Center, Department of Surgery, 330 Brookline Avenue, Boston, Massachusetts 02215, United States.
authors.forename: Bernard T
authors.initials: BT
authors.lastname: Lee
authors.affiliation: Boston University, Department of Biomedical Engineering, 44 Cummington Mall, Boston, Massachusetts 02215, United StatesdBoston University, Department of Electrical Engineering, 44 Cummington Mall, Boston, Massachusetts 02215, United States.
authors.forename: Irving J
authors.initials: IJ
authors.lastname: Bigio
authors.affiliation: Beth Israel Deaconess Medical Center, Department of Surgery, 330 Brookline Avenue, Boston, Massachusetts 02215, United StateseUniversity of Strasbourg, ICube Laboratory, 300 Boulevard Sébastien Brant, 67412 Illkirch, France.
authors.forename: Sylvain
authors.initials: S
authors.lastname: Gioux
mesh_terms: D000818:Animals; D003198:Computer Simulation; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D009010:Monte Carlo Method; D061848:Optical Imaging / Q000379:methods*; D019047:Phantoms, Imaging; D012867:Skin / Q000098:blood supply; D013552:Swine