title: Rapid functional cardiac imaging after gadolinium injection: Evaluation of a highly accelerated sequence with sparse data sampling and iterative reconstruction.
abstract: To generate a patient-friendly, time-efficient cardiac MRI examination protocol, a highly accelerated real-time CINE MR sequence (SSIR) was acquired in the idle time in between contrast injection and late gadolinium enhancement phase. 20 consecutive patients underwent a cardiac MRI examination including a multi-breath-hold sequence as gold standard (Ref) as well as SSIR sequences with (SSIR-BH) and without breath-hold (SSIR-nonBH). SSIR sequences were acquired 4 minutes after gadolinium injection. Right- (RV) and left-ventricular (LV) volumetric functional parameters were evaluated and compared between Ref and SSIR sequences. Despite reduced contrast between myocardium and intra-ventricular blood, volumetric as well as regional wall movement assessment revealed high agreement between both SSIR sequences and Ref. Excellent correlation and narrow limits of agreements were found for both SSIR-BH and SSIR-nonBH when compared to Ref for both LV (mean LV ejection fraction [EF] Ref: 52.8 ± 12.6%, SSIR-BH 52.3 ± 12.9%, SSIR-nonBH 52.5 ± 12.6%) and RV (mean RV EF Ref: 52.7 ± 9.4%, SSIR-BH 52.0 ± 8.1%, SSIR-nonBH 52.2 ± 9.3%) analyses. Even when acquired in the idle time in between gadolinium injection and LGE acquisition, the highly accelerated SSIR sequence delivers accurate volumetric and regional wall movement information. It thus seems ideal for very time-efficient and robust cardiac MR imaging protocols.
authors.affiliation: Department of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Germany.
authors.forename: Johannes
authors.initials: J
authors.lastname: Budjan
authors.affiliation: Department of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Germany.
authors.forename: Holger
authors.initials: H
authors.lastname: Haubenreisser
authors.affiliation: Department of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Germany.|DZHK (German Centre for Cardiovascular Research) partner site Mannheim, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Henzler
authors.affiliation: Department of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Germany.
authors.forename: Sonja
authors.initials: S
authors.lastname: Sudarski
authors.affiliation: MR Product Innovation and Definition, Siemens Healthcare GmbH, Erlangen, Germany.
authors.forename: Michaela
authors.initials: M
authors.lastname: Schmidt
authors.affiliation: DZHK (German Centre for Cardiovascular Research) partner site Mannheim, Germany.|1st Department of Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Germany.
authors.forename: Christina
authors.initials: C
authors.lastname: Doesch
authors.affiliation: DZHK (German Centre for Cardiovascular Research) partner site Mannheim, Germany.|1st Department of Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Germany.
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Akin
authors.affiliation: DZHK (German Centre for Cardiovascular Research) partner site Mannheim, Germany.|1st Department of Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Borggrefe
authors.affiliation: DZHK (German Centre for Cardiovascular Research) partner site Mannheim, Germany.|Computer Assisted Clinical Medicine, University Medical Center Mannheim, Heidelberg University, Mannheim, Germany.
authors.forename: Nadja M
authors.initials: NM
authors.lastname: Meßner
authors.affiliation: Department of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Germany.|DZHK (German Centre for Cardiovascular Research) partner site Mannheim, Germany.
authors.forename: Stefan O
authors.initials: SO
authors.lastname: Schoenberg
authors.affiliation: Department of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Germany.
authors.forename: Ulrike I
authors.initials: UI
authors.lastname: Attenberger
authors.affiliation: DZHK (German Centre for Cardiovascular Research) partner site Mannheim, Germany.|1st Department of Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Germany.
authors.forename: Theano
authors.initials: T
authors.lastname: Papavassiliu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003287:Contrast Media / Q000494:pharmacology*; D005260:Female; D005682:Gadolinium / Q000494:pharmacology*; D006321:Heart / Q000000981:diagnostic imaging*; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D016277:Ventricular Function, Left / Q000187:drug effects*
chemical_list: D003287:Contrast Media; D005682:Gadolinium