title: Asymmetric Chlorination of β-Keto Esters Using Diaminomethylenemalononitrile Organocatalyst.
abstract: Diaminomethylenemalononitrile organocatalysts promote the asymmetric chlorination of simple cyclic β-keto esters such as methyl, ethyl, and benzyl esters of 1-oxo-2,3-dihydro-1H-indene-2-carboxylic acid. This affords the corresponding chiral α-chlorinated carbonyl products in excellent yields with high enantioselectivities.
authors.affiliation: Tokyo University of Pharmacy and Life Sciences.
authors.forename: Takaaki
authors.initials: T
authors.lastname: Sakai
authors.forename: Shin-Ichi
authors.initials: SI
authors.lastname: Hirashima
authors.forename: Kosuke
authors.initials: K
authors.lastname: Nakashima
authors.forename: Chie
authors.initials: C
authors.lastname: Maeda
authors.forename: Akihiro
authors.initials: A
authors.lastname: Yoshida
authors.forename: Yuji
authors.initials: Y
authors.lastname: Koseki
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Miura
mesh_terms: D002384:Catalysis; D003959:Diamines / Q000737:chemistry*; D004952:Esters / Q000737:chemistry*; D054879:Halogenation; D006843:Hydrocarbons, Chlorinated / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D003959:Diamines; D004952:Esters; D006843:Hydrocarbons, Chlorinated; D009570:Nitriles