title: Do high-salt microenvironments drive hypertensive inflammation?
abstract: Hypertension is a global epidemic affecting over one billion people worldwide. Despite this, the etiology of most cases of human hypertension remains obscure, and treatment remains suboptimal. Excessive dietary salt and inflammation are known contributors to the pathogenesis of this disease. Recently, it has been recognized that salt can accumulate in the skin and skeletal muscle, producing concentrations of sodium greater than the plasma in hypertensive animals and humans. Such elevated levels of sodium have been shown to alter immune cell function. Here, we propose a model in which tissue salt accumulation causes an immune response leading to renal and vascular inflammation and hypertension.
authors.affiliation: Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee jason.d.foss@vanderbilt.edu.
authors.forename: Jason D
authors.initials: JD
authors.lastname: Foss
authors.affiliation: Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
authors.forename: Annet
authors.initials: A
authors.lastname: Kirabo
authors.affiliation: Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
authors.forename: David G
authors.initials: DG
authors.lastname: Harrison
mesh_terms: D000818:Animals; D060833:Cellular Microenvironment / Q000187:drug effects / Q000276:immunology*; D019317:Evidence-Based Medicine; D006801:Humans; D007113:Immunity, Innate / Q000187:drug effects / Q000276:immunology; D009393:Nephritis / Q000139:chemically induced / Q000276:immunology*; D017673:Sodium Chloride, Dietary / Q000009:adverse effects* / Q000276:immunology*; D014657:Vasculitis / Q000139:chemically induced / Q000276:immunology*
chemical_list: D017673:Sodium Chloride, Dietary
keywords: hypertension; inflammation; salt