title: Complete prefrontal lobe isolation surgery for recurrent epilepsy: A case report.
abstract: Epileptogenic focus resection is less effective for the treatment of frontal lobe epilepsy compared with temporal lobe epilepsy. However, there is currently a lack of effective therapeutic options for patients with frontal lobe epilepsy who are unsuitable for epileptogenic focus resection (such patients with epileptogenic foci in one frontal lobe in which the precise epileptic foci cannot be determined), or who experience recurrent epilepsy following epileptogenic focus resection. The present study reports a patient with frontal lobe epilepsy who underwent successful frontal lobe isolation surgery following a previous unsuccessful epileptogenic focus resection surgery. To ensure complete isolation of the prefrontal lobe, the surgery included division of the anterior commissure and the anterior part of the corpus callosum. The patient was followed-up for 16 months. Although the follow-up electroencephalogram presented a number of sharp waves on the affected side, the patient did not experience any seizures. The results suggest that prefrontal lobe isolation is an effective method of treating frontal lobe epilepsy, as division of the anterior commissure and the anterior part of the corpus callosum ensures disconnection of the prefrontal lobe from other regions of the brain.
authors.affiliation: Department of Neurosurgery, Tianjin Huanhu Hospital, Tianjin 300060, P.R. China.
authors.forename: Shaoya
authors.initials: S
authors.lastname: Yin
authors.affiliation: Department of Neurosurgery, Second Affiliated Hospital, Tianjin Medical University, Tianjin 300211, P.R. China.
authors.forename: Weipeng
authors.initials: W
authors.lastname: Jin
authors.affiliation: Department of Neurology, Tianjin Huanhu Hospital, Tianjin 300060, P.R. China.
authors.forename: Qingyun
authors.initials: Q
authors.lastname: Li
authors.affiliation: Department of Nerve Electrophysiology, Tianjin Huanhu Hospital, Tianjin 300060, P.R. China.
authors.forename: Mei
authors.initials: M
authors.lastname: Feng
authors.affiliation: Department of Neurosurgery, Tianjin Huanhu Hospital, Tianjin 300060, P.R. China.
authors.forename: Keke
authors.initials: K
authors.lastname: Feng
authors.affiliation: Department of Neurosurgery, Tianjin Huanhu Hospital, Tianjin 300060, P.R. China.
authors.forename: Hui
authors.initials: H
authors.lastname: Shao
authors.affiliation: Department of Nerve Electrophysiology, Tianjin Huanhu Hospital, Tianjin 300060, P.R. China.
authors.forename: Xueqing
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Neurology, Tianjin Huanhu Hospital, Tianjin 300060, P.R. China.
authors.forename: Shimin
authors.initials: S
authors.lastname: Wang
keywords: anterior commissure; corpus callosum; frontal lobe epilepsy; incision surgery; isolation surgery