title: Cutaneous Manifestation of Drug Allergy and Hypersensitivity.
abstract: Drug hypersensitivity reactions may manifest with either organ-specific or systemic symptoms, but cutaneous eruptions are the most common manifestations. Different medications may cause identical skin symptoms, whereas hypersensitivity to a single drug may manifest with various patterns of symptoms depending on the pathomechanism of hypersensitivity. Drug reactions should be also taken into account in the differential diagnosis of numerous skin rashes. Analysis of morphology of drug-induced lesions, about potential immunologic or nonimmunological mechanisms, is important for the final diagnosis. Thus, here the authors present a morphologic approach to the diagnosis of cutaneous drug-induced eruptions.
authors.affiliation: Department of Psychodermatology, Medical University of Lodz, 251 Pomorska Street, Lodz 92-213, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Zalewska-Janowska
authors.affiliation: Department of Experimental Dermatology and Cosmetology, Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna Street, Krakow 30-688, Poland.
authors.forename: Radoslaw
authors.initials: R
authors.lastname: Spiewak
authors.affiliation: Department of Immunology, Rheumatology and Allergy, Medical University of Lodz, 251 Pomorska Street, Lodz 92-213, Poland. Electronic address: kowalsml@csk.umed.lodz.pl.
authors.forename: Marek L
authors.initials: ML
authors.lastname: Kowalski
mesh_terms: D000707:Anaphylaxis; D000799:Angioedema; D003937:Diagnosis, Differential; D003875:Drug Eruptions / Q000175:diagnosis* / Q000276:immunology; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000175:diagnosis* / Q000276:immunology; D012867:Skin / Q000276:immunology / Q000473:pathology*; D014581:Urticaria
keywords: Cutaneous adverse drug reactions (CADR); Cutaneous manifestations; Drug allergy; Drug hypersensitivity; Photoallergy