title: Effects of Abies sibirica terpenes on cancer- and aging-associated pathways in human cells.
abstract: A large number of terpenoids exhibit potential geroprotector and anti-cancer properties. Here, we studied whole transcriptomic effects of Abisil, the extract of fir (Abies sibirica) terpenes, on normal and cancer cell lines. We used early passaged and senescent none-immortalized fibroblasts as cellular aging models. It was revealed that in normal fibroblasts, terpenes induced genes of stress response, apoptosis regulation and tissue regeneration. The restoration of the expression level of some prolongevity genes after fir extract treatment was shown in old cells. In Caco-2 and AsPC-1 cancer cell lines, Abisil induced expression of both onco-suppressors (members of GADD45, DUSP, and DDIT gene families), and proto-oncogenes (c-Myc, c-Jun, EGR and others). Thus, the study demonstrates the potential anti-aging and anti-cancer effects of Abisil on senescent and cancer cell lines.
authors.affiliation: Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991, Russia.|National Medical Research Radiological Center, Ministry of Health of the Russian Federation, Moscow, 125284, Russia.
authors.forename: Anna
authors.initials: A
authors.lastname: Kudryavtseva
authors.affiliation: Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991, Russia.
authors.forename: George
authors.initials: G
authors.lastname: Krasnov
authors.affiliation: Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991, Russia.
authors.forename: Anastasiya
authors.initials: A
authors.lastname: Lipatova
authors.affiliation: National Medical Research Radiological Center, Ministry of Health of the Russian Federation, Moscow, 125284, Russia.
authors.forename: Boris
authors.initials: B
authors.lastname: Alekseev
authors.affiliation: Initium-Pharm, LTD, Moscow, 142000, Russia.
authors.forename: Faniya
authors.initials: F
authors.lastname: Maganova
authors.affiliation: Institute of Biology of Komi Science Center of Ural Branch of RAS, Syktyvkar, 167982, Russia.
authors.forename: Mikhail
authors.initials: M
authors.lastname: Shaposhnikov
authors.affiliation: Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991, Russia.
authors.forename: Maria
authors.initials: M
authors.lastname: Fedorova
authors.affiliation: Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991, Russia.
authors.forename: Anastasiya
authors.initials: A
authors.lastname: Snezhkina
authors.affiliation: Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991, Russia.|Institute of Biology of Komi Science Center of Ural Branch of RAS, Syktyvkar, 167982, Russia.|Moscow Institute of Physics and Technology, Dolgoprudny, 141700, Russia.
authors.forename: Alexey
authors.initials: A
authors.lastname: Moskalev
mesh_terms: D028202:Abies / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology*; D018938:Caco-2 Cells; D049109:Cell Proliferation / Q000187:drug effects; D016922:Cellular Senescence / Q000187:drug effects* / Q000235:genetics; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D015972:Gene Expression Regulation, Neoplastic; D053263:Gene Regulatory Networks; D006801:Humans; D010190:Pancreatic Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D008517:Phytotherapy; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D010946:Plants, Medicinal; D015398:Signal Transduction / Q000187:drug effects; D013729:Terpenes / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D013729:Terpenes
keywords: Abies sibirica; anti-aging effects; anti-cancer effects; plant extract; terpenoids