title: The International Nuclear Workers Study (Inworks): A Collaborative Epidemiological Study to Improve Knowledge About Health Effects of Protracted Low-Dose Exposure.
abstract: INWORKS is a multinational cohort study, gathering 308 297 workers in the nuclear industry in France, the United Kingdom and the United States of America, with detailed individual monitoring data for external exposure to ionising radiation. Over a mean duration of follow-up of 27 y, the number of observed deaths was 66 632, including 17 957 deaths due to solid cancers, 1791 deaths due to haematological cancers and 27 848 deaths due to cardiovascular diseases. Mean individual cumulative external dose over the period 1945-2005 was 25 mSv. Analyses demonstrated a significant association between red bone marrow dose and the risk of leukaemia (excluding chronic lymphocytic leukaemia) and between colon dose and the risk of solid cancers. INWORKS assembled some of the strongest evidence to strengthen the scientific basis for the protection of adults from low dose, low-dose rate, exposures to ionising radiation.
authors.affiliation: Institut de Radioprotection et de Sûreté Nucléaire (IRSN), 91190 Fontenay-aux-Roses, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Laurier
authors.affiliation: Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA.
authors.forename: David B
authors.initials: DB
authors.lastname: Richardson
authors.affiliation: ISGLOBAL, Barcelona, Spain.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Cardis
authors.affiliation: National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA.
authors.forename: Robert D
authors.initials: RD
authors.lastname: Daniels
authors.affiliation: Public Health England Centre for Radiation, Chemical and Environmental Hazards (PHE-CRCE), Chilton, UK.
authors.forename: Michael
authors.initials: M
authors.lastname: Gillies
authors.affiliation: Public Health England Centre for Radiation, Chemical and Environmental Hazards (PHE-CRCE), Chilton, UK.
authors.forename: Jackie
authors.initials: J
authors.lastname: O'Hagan
authors.affiliation: Department of Environmental and Occupational Health, Drexel University School of Public Health, Philadelphia, PA, USA.
authors.forename: Ghassan B
authors.initials: GB
authors.lastname: Hamra
authors.affiliation: Public Health England Centre for Radiation, Chemical and Environmental Hazards (PHE-CRCE), Chilton, UK.
authors.forename: Richard
authors.initials: R
authors.lastname: Haylock
authors.affiliation: Institut de Radioprotection et de Sûreté Nucléaire (IRSN), 91190 Fontenay-aux-Roses, France.
authors.forename: Klervi
authors.initials: K
authors.lastname: Leuraud
authors.affiliation: International Agency for Research on Cancer, Lyon, France.
authors.forename: Monika
authors.initials: M
authors.lastname: Moissonnier
authors.affiliation: National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA.
authors.forename: Mary K
authors.initials: MK
authors.lastname: Schubauer-Berigan
authors.affiliation: International Agency for Research on Cancer, Lyon, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Thierry-Chef
authors.affiliation: International Agency for Research on Cancer, Lyon, France.
authors.forename: Ausrele
authors.initials: A
authors.lastname: Kesminiene
mesh_terms: D015331:Cohort Studies; D005602:France / Q000453:epidemiology; D006801:Humans; D009381:Neoplasms, Radiation-Induced / Q000453:epidemiology*; D009784:Occupational Diseases; D016273:Occupational Exposure; D011829:Radiation Dosage; D006113:United Kingdom / Q000453:epidemiology; D014481:United States / Q000453:epidemiology