title: Prediction of Post-operative Mortality in Patients with HCV-related Cirrhosis Undergoing Non-Hepatic Surgeries.
abstract: BACKGROUND
  Patients with chronic liver diseases are at great risk for both morbidity and mortality during the post-operative period due to the stress of surgery and the effects of general anaesthesia.
  
  
  OBJECTIVE
  The main aim of this study was to evaluate the value of Model for End-stage Liver Disease (MELD) score, as compared to Child-Turcotte-Pugh (CTP) score, for prediction of 30- day post-operative mortality in Egyptian patients with liver cirrhosis undergoing non-hepatic surgery under general anaesthesia.
  
  
  METHODS
  A total of 60 patients with Hepatitis C Virus (HCV) - related liver cirrhosis were included in this study. Sensitivity and specificity of MELD and CTP scores were evaluated for the prediction of post-operative mortality. A total of 20 patients who had no clinical, biochemical or radiological evidence of liver disease were included to serve as a control group.
  
  
  RESULTS
  The highest sensitivity and specificity for detection of post-operative mortality was detected at a MELD score of 13.5. CTP score had a sensitivity of 75%, a specificity of 96.4%, and an overall accuracy of 95% for prediction of post-operative mortality. On the other side and at a cut-off value of 13.5, MELD score had a sensitivity of 100%, a specificity of 64.0%, and an overall accuracy of 66.6% for prediction of post-operative mortality in patients with HCV- related liver cirrhosis.
  
  
  CONCLUSIONS
  MELD score proved to be more sensitive but less specific than CTP score for prediction of post-operative mortality. CTP and MELD scores may be complementary rather than competitive in predicting post-operative mortality in patients with HCV- related liver cirrhosis.
authors.affiliation: Professor, Department of Internal Medicine, Aim Shams University , Cairo, Egypt .
authors.forename: Khalid
authors.initials: K
authors.lastname: Hemida
authors.affiliation: Assistant Professor, Department of Internal Medicine, Aim Shams University , Cairo, Egypt .
authors.forename: Reham Ezzat
authors.initials: RE
authors.lastname: Al Swaff
authors.affiliation: Assistant Professor, Department of Internal Medicine, Aim Shams University , Cairo, Egypt .
authors.forename: Sherif Sadek
authors.initials: SS
authors.lastname: Shabana
authors.affiliation: Assistant Professor, Department of General Surgery, Aim Shams University , Cairo, Egypt .
authors.forename: Hani
authors.initials: H
authors.lastname: Said
authors.affiliation: Assistant Professor, Department of Tropical Medicine, Aim Shams University , Cairo, Egypt .
authors.forename: Fatma
authors.initials: F
authors.lastname: Ali-Eldin
keywords: Child-turcotte-pugh score; Model for end-stage liver disease score; Post-operative mortality