title: Role of resistance physical exercise in preventing testicular damage caused by chronic ethanol consumption in UChB rats.
abstract: Ethanol consumption is associated with spermatogenesis damage and testosterone level alterations. Alcohol remains the most commonly used substance among athletes and sports enthusiasts. This study evaluated whether resistance physical exercise can reduce the testicular damage caused by ethanol exposure. A total of 36 ethanol drinking (UChB) rats were divided into four groups: C (control rats), ETOH (ethanol consumption), ETOH + T (ethanol consumption + physical training), and T (group physical training). The physical training component of the T and ETOH + T groups was based on a resistance training model consisting of four sets of 10 jumps, with an increasing overload of 50-70% of the body weight attached to the chest three times per week. Rats in the ETOH and ETOH +T groups received 10% ethanol. At postnatal day 90, the rats were sacrificed. Blood sample was collected for hormonal analysis, and the testicles were weighed and processed for histopathological, morphometric, and immunohistochemical analyses. The ETOH group showed an increase in testosterone levels. The immunohistochemical of androgen receptor and the absolute weight of the testes were higher in the ETOH and ETOH + T groups, while the ETOH animals showed a decreased weight gain index. The number of abnormal seminiferous tubules increased in the ETOH and T groups compared to those in the control group (C); however, the association with treatment (ETOH + T group) prevented this effect and decreased caspase-3 production. In conclusion, these findings show that the combination of ethanol consumption and resistance physical exercise can prevent testicular damage in adult UChB rats.
authors.affiliation: Department of General Biology, Biological Sciences Center, State University of Londrina - UEL, Londrina, Paraná, 86057-970, Brazil.|Department of General Pathology, Biological Sciences Center, State University of Londrina - UEL, Londrina, Paraná, 86057-970, Brazil.
authors.forename: Gessica
authors.initials: G
authors.lastname: Dutra Gonçalves
authors.affiliation: Department of General Pathology, Biological Sciences Center, State University of Londrina - UEL, Londrina, Paraná, 86057-970, Brazil.
authors.forename: Nichelle
authors.initials: N
authors.lastname: Antunes Vieira
authors.affiliation: Department of General Biology, Biological Sciences Center, State University of Londrina - UEL, Londrina, Paraná, 86057-970, Brazil.
authors.forename: Henrique
authors.initials: H
authors.lastname: Rodrigues Vieira
authors.affiliation: Department of General Biology, Biological Sciences Center, State University of Londrina - UEL, Londrina, Paraná, 86057-970, Brazil.
authors.forename: Aline
authors.initials: A
authors.lastname: Dias Valério
authors.affiliation: Department of General Biology, Biological Sciences Center, State University of Londrina - UEL, Londrina, Paraná, 86057-970, Brazil.|Department of General Pathology, Biological Sciences Center, State University of Londrina - UEL, Londrina, Paraná, 86057-970, Brazil.
authors.forename: Gláucia
authors.initials: G
authors.lastname: Elóisa Munhoz de Lion Siervo
authors.affiliation: Department of Anatomy, Biosciences Institute, University Paulista, Presidente Prudente (UNESP), Botucatu, São Paulo, 18618-000, Brazil.
authors.forename: Patricia
authors.initials: P
authors.lastname: Fernanda Felipe Pinheiro
authors.affiliation: Department of Anatomy, Biosciences Institute, University Paulista, Presidente Prudente (UNESP), Botucatu, São Paulo, 18618-000, Brazil.
authors.forename: Francisco
authors.initials: F
authors.lastname: Eduardo Martinez
authors.affiliation: Department of General Pathology, Biological Sciences Center, State University of Londrina - UEL, Londrina, Paraná, 86057-970, Brazil.
authors.forename: Flávia
authors.initials: F
authors.lastname: Alessandra Guarnier
authors.affiliation: Department of Physical Education, Center of Science and Technology, University Paulista, Presidente Prudente (UNESP), Educational Center, 305, Presidente Prudente, São Paulo, 19060-080, Brazil.
authors.forename: Giovana
authors.initials: G
authors.lastname: Rampazzo Teixeira
authors.affiliation: Department of General Biology, Biological Sciences Center, State University of Londrina - UEL, Londrina, Paraná, 86057-970, Brazil.
authors.forename: Glaura
authors.initials: G
authors.lastname: Scantamburlo Alves Fernandes
mesh_terms: D000428:Alcohol Drinking / Q000009:adverse effects*; D020751:Alcohol-Induced Disorders / Q000473:pathology; D000437:Alcoholism / Q000473:pathology; D000818:Animals; D053148:Caspase 3 / Q000032:analysis; D000431:Ethanol / Q000633:toxicity*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011944:Receptors, Androgen / Q000032:analysis; D055070:Resistance Training; D012671:Seminiferous Tubules / Q000473:pathology*; D013091:Spermatogenesis / Q000187:drug effects / Q000502:physiology*; D013739:Testosterone / Q000097:blood
chemical_list: D011944:Receptors, Androgen; D000431:Ethanol; D013739:Testosterone; D053148:Caspase 3
keywords: UChB rats; ethanol; resistance physical exercise; testes