title: New-onset diabetes after kidney transplantation: Incidence, risk factors, and outcomes.
abstract: Many patients develop new-onset diabetes after kidney transplantation (NODAT). Its incidence and epidemiology are unknown in the Saudi population. We aimed to study the incidence, epidemiology, and outcomes of kidney transplant recipients who developed NODAT. This is a retrospective study of all adults who received kidney transplant between January 2003 and December 2009. NODAT was defined according to the criteria outlined in the 2003 International Consensus guidelines. A total of 500 patients were included in this study, 54% were male patients. One hundred thirty-six patients (27%) developed diabetes (NODAT group). In the univariate analysis, patients were older in the NODAT group (P <0.001), were of higher weight (P = 0.006), and had positive family history of diabetes (P = 0.002). Similarly, more patients in this group had impaired glucose tolerance before transplant (P = 0.01) and history of hepatitis C infection (P = 0.005). In the multivariate analysis, older age [odds ratio (OR) 1.06], family history of diabetes (OR 1.09), hepatitis C infection (OR 1.92), and impaired fasting glucose (OR 1.79) were significant risk factors for the development of NODAT. Mortality was 6% in the NODAT group and 0.5% in the non-diabetic group had died (P <0.001). Graft survival was not different between the groups (P = 0.35). In conclusion, there is a significant risk of developing diabetes after renal transplantation. Patients are at higher risk if they are older, have a family history of diabetes, pre-transplant impaired fasting/random glucose, and hepatitis C virus infection.
authors.affiliation: Department of Kidney and Pancreas Transplantation, King Faisal Specialist Hospital, Riyadh, Saudi Arabia.
authors.forename: Hassan
authors.initials: H
authors.lastname: Aleid
authors.affiliation: Department of Medicine, King Faisal Specialist Hospital, Riyadh, Saudi Arabia.
authors.forename: Ahmad
authors.initials: A
authors.lastname: Alhuraiji
authors.affiliation: Department of Medicine, King Faisal Specialist Hospital, Riyadh, Saudi Arabia.
authors.forename: Abdullah
authors.initials: A
authors.lastname: Alqaraawi
authors.affiliation: Department of Kidney and Pancreas Transplantation, King Faisal Specialist Hospital, Riyadh, Saudi Arabia.
authors.forename: Ammar
authors.initials: A
authors.lastname: Abdulbaki
authors.affiliation: Department of Kidney and Pancreas Transplantation, King Faisal Specialist Hospital, Riyadh, Saudi Arabia.
authors.forename: Mai
authors.initials: M
authors.lastname: Altalhi
authors.affiliation: Department of Biostatistics and Epidemiology, King Faisal Specialist Hospital, Riyadh, Saudi Arabia.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Shoukri
authors.affiliation: Department of Biostatistics and Epidemiology, King Faisal Specialist Hospital, Riyadh, Saudi Arabia.
authors.forename: Eldali
authors.initials: E
authors.lastname: Abdelmoneim
authors.affiliation: Department of Kidney and Pancreas Transplantation, King Faisal Specialist Hospital, Riyadh, Saudi Arabia.
authors.forename: Tariq
authors.initials: T
authors.lastname: Ali
mesh_terms: D003920:Diabetes Mellitus; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents; D015994:Incidence; D016030:Kidney Transplantation; D008297:Male; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D007166:Immunosuppressive Agents