title: Cardiac inositol 1,4,5-trisphosphate receptors.
abstract: Calcium is a second messenger that regulates almost all cellular functions. In cardiomyocytes, calcium plays an integral role in many functions including muscle contraction, gene expression, and cell death. Inositol 1,4,5-trisphosphate receptors (IP3Rs) are a family of calcium channels that are ubiquitously expressed in all tissues. In the heart, IP3Rs have been associated with regulation of cardiomyocyte function in response to a variety of neurohormonal agonists, including those implicated in cardiac disease. Notably, IP3R activity is thought to be essential for mediating the hypertrophic response to multiple stimuli including endothelin-1 and angiotensin II. In this review, we will explore the functional implications of IP3R activity in the heart in health and disease.
authors.affiliation: Cell Biology Graduate Program, University of Texas Medical Branch, Galveston, TX 77555, United States; Department of Biochemistry and Molecular Biology, McGovern Medical School at UTHealth, Houston, TX 77030, United States.
authors.forename: M Iveth
authors.initials: MI
authors.lastname: Garcia
authors.affiliation: Department of Biochemistry and Molecular Biology, McGovern Medical School at UTHealth, Houston, TX 77030, United States. Electronic address: darren.f.boehning@uth.tmc.edu.
authors.forename: Darren
authors.initials: D
authors.lastname: Boehning
mesh_terms: D000818:Animals; D006332:Cardiomegaly / Q000378:metabolism; D006801:Humans; D053496:Inositol 1,4,5-Trisphosphate Receptors / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*
chemical_list: D053496:Inositol 1,4,5-Trisphosphate Receptors
keywords: Calcium channels; Cardiac hypertrophy; IP(3) Receptor