title: Degradation of paraoxon (VX chemical agent simulant) and bacteria by magnesium oxide depends on the crystalline structure of magnesium oxide.
abstract: In this work, our goal was to study the capability of a single metallic oxide to neutralize a chemical agent and to exhibit an antibacterial effect. We tested two types of magnesium oxides, MgO. The first MgO sample tested, which commercial data size characteristic was -325 mesh (MgO-1) destroyed in 3 h, 89.7% of paraoxon and 93.2% of 4-nitrophenol, the first degradation product. The second MgO sample, which commercial data size was <50 nm (MgO-2) neutralized in the same time, 19.5% of paraoxon and 10.9% of 4-nitrophenol. For MgO-1 no degradation products could be detected by GC-MS. MgO-1 had a bactericidal activity on Escherichia coli (6 log in 1 h), and showed a decrease of almost 3 log on a Staphylococcus aureus population in 3 h. MgO-2 caused a decrease of 2 log of a E.coli culture but had no activity against S. aureus. Neither of these two products had an activity on Bacillus subtilis spores. Analytical investigations showed that the real sizes of MgO nanoparticles were 11 nm for MgO-1 and 25 nm for MgO-2. Moreover, their crystalline structures were different. These results highlighted the importance of the size of the nanoparticles and their microscopic arrangements to detoxify chemical products and to inhibit or kill microbial strains.
authors.affiliation: OUVRY SAS, 24 av. Joannès Masset, F-69009 Lyon, France; UMR CNRS 5007, LAGEP, University Claude Bernard Lyon1, 43 bd du 11 novembre, F-69622 Villeurbanne, France; UMR CNRS 5510, Mateis I2B, University Claude Bernard Lyon1, 7 rue Guillaume Paradin, F-69372 Lyon, France.
authors.forename: A
authors.initials: A
authors.lastname: Sellik
authors.affiliation: OUVRY SAS, 24 av. Joannès Masset, F-69009 Lyon, France.
authors.forename: T
authors.initials: T
authors.lastname: Pollet
authors.affiliation: OUVRY SAS, 24 av. Joannès Masset, F-69009 Lyon, France.
authors.forename: L
authors.initials: L
authors.lastname: Ouvry
authors.affiliation: UMR CNRS 5007, LAGEP, University Claude Bernard Lyon1, 43 bd du 11 novembre, F-69622 Villeurbanne, France.
authors.forename: S
authors.initials: S
authors.lastname: Briançon
authors.affiliation: UMR CNRS 5007, LAGEP, University Claude Bernard Lyon1, 43 bd du 11 novembre, F-69622 Villeurbanne, France.
authors.forename: H
authors.initials: H
authors.lastname: Fessi
authors.affiliation: UMR CNRS 5510, Mateis I2B, University Claude Bernard Lyon1, 7 rue Guillaume Paradin, F-69372 Lyon, France.
authors.forename: D J
authors.initials: DJ
authors.lastname: Hartmann
authors.affiliation: OUVRY SAS, 24 av. Joannès Masset, F-69009 Lyon, France; UMR CNRS 5510, Mateis I2B, University Claude Bernard Lyon1, 7 rue Guillaume Paradin, F-69372 Lyon, France. Electronic address: renaud@ouvry.com.
authors.forename: F N R
authors.initials: FN
authors.lastname: Renaud
mesh_terms: D001412:Bacillus subtilis / Q000502:physiology; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development; D008401:Gas Chromatography-Mass Spectrometry; D008277:Magnesium Oxide / Q000032:analysis / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000633:toxicity; D009596:Nitrophenols / Q000737:chemistry; D009946:Organothiophosphorus Compounds / Q000737:chemistry*; D010261:Paraoxon / Q000737:chemistry*; D010316:Particle Size; D013171:Spores, Bacterial / Q000187:drug effects / Q000254:growth & development; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development
chemical_list: D008277:Magnesium Oxide; D009596:Nitrophenols; D009946:Organothiophosphorus Compounds; D010261:Paraoxon; C009680:VX-agent; C024836:4-nitrophenol
keywords: Decontamination; Disinfection; Escherichia coli; Magnesium oxide; Paraoxon; Staphylocoocus aureus