title: Application of transrectal ultrasound-guided repeat needle biopsy in the diagnosis of prostate cancer in Chinese population: A retrospective study.
abstract: BACKGROUND
  Transrectal ultrasound-guided repeat needle biopsy (TUGRNB) is widely used for diagnosis of prostate cancer (PCa). However, significance of TUGRNB in Chinese population was rarely reported. A retrospective study was conducted to evaluate the significance of TUGRNB applied in prediction of PCa in Chinese population.
  
  
  METHODS
  A total of 960 from January 2009 to December 2012 were included. Repeat needle biopsy rate and PCa positive detection rate were evaluated. Relationship between prostate specific antigen (PSA) levels and PCa positive rates was analyzed.
  
  
  RESULTS
  PCa positive detection rate after initial needle biopsy was 28.4%, which was lower than the rate of repeat needle biopsy (40%). The rate for immediate transurethral resection (TUR), surgery after initial needle biopsy, was 27.1%, however with a low PCa positive detection rate (0.66%). The repeat needle biopsy rate was lower compared with the initial biopsy rate (P< 0.05). Meanwhile, immediate TUR rate was significantly higher than that of the repeat needle biopsy rate (P< 0.05). Among the three groups, the PCa positive detection rate in repeat needle biopsy group was the highest. In subgroups with different PSA levels, the PCa positive rate increased with the elevation of PSA level. In cases with PSA > 20 ng/ml, PCa positive rate was significantly higher than those with PSA < 20 ng/ml (P< 0.05).
  
  
  CONCLUSIONS
  PCa positive detection rate following repeat needle biopsy in Chinese population was higher, although the repeated needle biopsy rate was still in a low level. TUGRNB should attract more attention in the diagnosis of PCa.
authors.affiliation: Department of Urology, The Suzhou Kowloon Hospital Affiliated to Shanghai Jiaotong University, Medical School, Suzhou, Jiangsu, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Urology, The Suzhou Kowloon Hospital Affiliated to Shanghai Jiaotong University, Medical School, Suzhou, Jiangsu, China.
authors.forename: Xizhi
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Urology, The Suzhou Kowloon Hospital Affiliated to Shanghai Jiaotong University, Medical School, Suzhou, Jiangsu, China.
authors.forename: Jiang
authors.initials: J
authors.lastname: Yu
authors.affiliation: Department of Urology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Ouyang
authors.affiliation: Department of Ultrasonography, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
authors.forename: Weidong
authors.initials: W
authors.lastname: Shen
authors.affiliation: Department of Urology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
authors.forename: Yibin
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Department of Urology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
authors.forename: Jianquan
authors.initials: J
authors.lastname: Hou
authors.affiliation: Department of Urology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
authors.forename: Duangai
authors.initials: D
authors.lastname: Wen
authors.affiliation: Department of Urology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
authors.forename: Jinxian
authors.initials: J
authors.lastname: Pu
authors.affiliation: Department of Urology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
authors.forename: Yuxi
authors.initials: Y
authors.lastname: Shan
authors.affiliation: Department of Urology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
authors.forename: Boxin
authors.initials: B
authors.lastname: Xue
keywords: Prostate cancer; prostate specific antigen; repeat needle biopsy