title: [Acute kidney injury - status of biomarkers in perioperative and critically ill patients].
abstract: Acute kidney injury (AKI) impairs short- and long-term prognosis of affected patients even in case of apparantly mild course and 'full' recovery as measured by follow-up serum creatinine concentrations. Late or none intervention worsens prognosis. However, there are modifiable factors potentially contributing to preserved long-term renal function. Effective treatment is multifactorial and includes identification and reversal of AKI etiology and generation of a (micro)environment for optimal renal recovery. Available treatment options for AKI in perioperative and critically ill patients will be discussed in the setting of novel kidney biomarkers.
authors.affiliation: Institut für Sozialmedizin und Gesundheitsökonomie, Otto-von-Guericke Universität Magdeburg.
authors.forename: Anja
authors.initials: A
authors.lastname: Haase-Fielitz
authors.affiliation: Universitätsklinik für Nieren- und Hochdruckkrankheiten, Diabetologie und Endokrinologie.
authors.forename: Michael
authors.initials: M
authors.lastname: Haase
mesh_terms: D058186:Acute Kidney Injury / Q000097:blood* / Q000175:diagnosis; D015415:Biomarkers / Q000097:blood; D003404:Creatinine / Q000097:blood*; D016638:Critical Illness; D055316:Cystatin C / Q000097:blood*; D019317:Evidence-Based Medicine; D006801:Humans; D018969:Insulin-Like Growth Factor Binding Proteins / Q000097:blood; D007431:Intraoperative Complications / Q000097:blood* / Q000175:diagnosis; D000071068:Lipocalin-2 / Q000097:blood*; D016343:Monitoring, Intraoperative / Q000379:methods; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D019716:Tissue Inhibitor of Metalloproteinase-2 / Q000097:blood*
chemical_list: D015415:Biomarkers; D055316:Cystatin C; D018969:Insulin-Like Growth Factor Binding Proteins; C489506:LCN2 protein, human; D000071068:Lipocalin-2; C102529:insulin-like growth factor binding protein-related protein 1; D019716:Tissue Inhibitor of Metalloproteinase-2; D003404:Creatinine