title: Antibacterial ability and hemocompatibility of graphene functionalized germanium.
abstract: Germanium (Ge), as an elemental semiconductor material, has been an attractive candidate for manufacturing semiconductor microelectronic device. In the present investigation, to improve the biocompatibility of Ge-based device, graphene film is directly deposited on the Ge surface with different coverage area by controlling the growth time. Compared to bare Ge, the presence of graphene film entitles Ge with satisfactory antibacterial ability against Staphylococcus aureus (S.aureus), and acceptable antibacterial ability against Escherichia coli (E. coli). Meanwhile, antibacterial efficiency closely correlates with coverage area of graphene film, and larger graphene coverage always leads to better antibacterial performance. The underlying mechanism is thought to be the integrative action of phospholipids disturbance and electron extraction at the interface between graphene and biomembrane. Meanwhile, the electron extraction action would further lead to the activation of platelet. This study might provide some new insights into the relationship between antibacterial ability and hemocompatibility based on graphene functionalized biomedical device.
authors.affiliation: State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China.|University of Chinese Academy of Sciences, Beijing 100049, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Geng
authors.affiliation: State Key Laboratory of Functional Materials for Informatics, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, China.|University of Chinese Academy of Sciences, Beijing 100049, China.
authors.forename: Jiayun
authors.initials: J
authors.lastname: Dai
authors.affiliation: State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China.|University of Chinese Academy of Sciences, Beijing 100049, China.
authors.forename: Jinhua
authors.initials: J
authors.lastname: Li
authors.affiliation: State Key Laboratory of Functional Materials for Informatics, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, China.
authors.forename: Zengfeng
authors.initials: Z
authors.lastname: Di
authors.affiliation: State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China.
authors.forename: Xuanyong
authors.initials: X
authors.lastname: Liu