title: [Retention of contrast media in the history of radiology : Sequelae of the former use of thorotrast and new challenges].
abstract: Detection of gadolinium deposits in patients who have repeatedly been administered intravenous gadolinium chelates have given rise to concern regarding the long-term safety of magnetic resonance imaging (MRI) contrast media. Nevertheless, negative long-term clinical effects have not yet been observed. In some publications parallels have been drawn to the sequelae of thorotrast that was formerly used for arterial angiography. In this article the history of thorotrast use is briefly described and in particular why, despite warnings, this substance was used frequently and worldwide. A brief summary of the results of the German Thorotrast Study revealed that high excess rates were only observed for primary malignant liver tumors after a 15-year or longer latency period and to a lesser degree of leukemias, as well as for severe local complications due to paravascular injections, particularly in the neck region. Based on this historical review, we will venture to take stock of the outcome from the "success story" of this contrast agent.
authors.affiliation: Deutsches Krebsforschungszentrum (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Deutschland. spannagelkaick@t-online.de.
authors.forename: G
authors.initials: G
authors.lastname: van Kaick
authors.affiliation: Deutsches Krebsforschungszentrum (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Deutschland. s.delorme@dkfz-heidelberg.de.
authors.forename: S
authors.initials: S
authors.lastname: Delorme
mesh_terms: D000792:Angiography / Q000266:history*; D056486:Chemical and Drug Induced Liver Injury / Q000266:history*; D003287:Contrast Media / Q000266:history*; D005858:Germany; D049673:History, 20th Century; D006801:Humans; D008113:Liver Neoplasms / Q000266:history*; D011871:Radiology / Q000266:history*; D013911:Thorium Dioxide / Q000266:history*
chemical_list: D003287:Contrast Media; D013911:Thorium Dioxide
keywords: Cancer risk; Cohort studies; Leukemia; Liver neoplasms; Radiation-induced carcinogenesis