title: Spectroscopic investigation, vibrational assignments, HOMO-LUMO, NBO, MEP analysis and molecular docking studies of oxoaporphine alkaloid liriodenine.
abstract: A combined experimental and theoretical DFT study of the structural, vibrational and electronic properties of liriodenine is presented using B3LYP function with 6-311G (2d, p) basis set. The theoretical geometry optimization data were compared with the X-ray data for a similar structure in the associated literature, showing similar values. In addition, natural bond orbitals (NBOs), HOMO-LUMO energy gap, mapped molecular Electrostatic Potential (MEP) surface calculation, first and second order hyperpolarizabilities were also performed with the same calculation level. Theoretical UV spectrum agreed well with the measured experimental data, with transitions assigned. The molecular electrostatic potential map shows opposite potentials regions that forms hydrogen bonds that stabilize the dimeric form, which were confirmed by the close values related to the CO bond stretching between the dimeric form and the experimental IR spectra (1654cm-1for the experimental, 1700cm-1for the dimer form). Calculated HOMO/LUMO gaps shows the excitation energy for Liriodenine, justifying its stability and kinetics reaction. Molecular docking studies with Candida albicans dihydrofolate reductase (DHFR) and Candida albicans secreted aspartic protease (SAP) showed binding free energies values of -8.5 and -8.3kcal/mol, suggesting good affinity between the liriodenine and the target macromolecules.
authors.affiliation: LQTC Laboratory, Department of Chemistry, Federal University of Amazonas, Manaus, Amazonas, Brazil. Electronic address: renyer.costa@gmail.com.
authors.forename: Renyer A
authors.initials: RA
authors.lastname: Costa
authors.affiliation: LQTC Laboratory, Department of Chemistry, Federal University of Amazonas, Manaus, Amazonas, Brazil.
authors.forename: Priscilla Olliveira
authors.initials: PO
authors.lastname: Pitt
authors.affiliation: LQTC Laboratory, Department of Chemistry, Federal University of Amazonas, Manaus, Amazonas, Brazil.
authors.forename: Maria Lucia B
authors.initials: MLB
authors.lastname: Pinheiro
authors.affiliation: LQTC Laboratory, Department of Chemistry, Federal University of Amazonas, Manaus, Amazonas, Brazil. Electronic address: kelsonmota@ufam.edu.br.
authors.forename: Kelson M T
authors.initials: KMT
authors.lastname: Oliveira
authors.affiliation: NMR Laboratory, Department of Chemistry, Federal University of Paraná, Paraná, Curitiba, Brazil.
authors.forename: Kahlil Schwanka
authors.initials: KS
authors.lastname: Salomé
authors.affiliation: NMR Laboratory, Department of Chemistry, Federal University of Paraná, Paraná, Curitiba, Brazil.
authors.forename: Andersson
authors.initials: A
authors.lastname: Barison
authors.affiliation: LQTC Laboratory, Department of Chemistry, Federal University of Amazonas, Manaus, Amazonas, Brazil.
authors.forename: Emmanoel Vilaça
authors.initials: EV
authors.lastname: Costa
mesh_terms: D000470:Alkaloids / Q000737:chemistry*; D001060:Aporphines / Q000737:chemistry*; D005656:Fungal Proteins / Q000737:chemistry / Q000378:metabolism; D008024:Ligands; D008968:Molecular Conformation; D062105:Molecular Docking Simulation; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D055672:Static Electricity; D013816:Thermodynamics; D014732:Vibration
chemical_list: D000470:Alkaloids; D001060:Aporphines; D005656:Fungal Proteins; D008024:Ligands; C026980:liriodenine
keywords: Aporphine alkaloid; DFT; FT-IR; Hyperpolarizabily; Molecular docking; UV-VIS