title: Effectiveness of Centchroman on Regression of Fibroadenosis and Mastalgia.
abstract: BACKGROUND
  Fibroadenosis and mastalgia are common among the women in reproductive age group. Treatment for these conditions is not yet standardised. Most of the drugs used for fibroadenosis and mastalgia are expensive and have side effects.
  
  
  OBJECTIVE
  To find out the efficacy of centchroman, a Selective Estrogens Receptor Modulator (SERM) on regression of fibroadenosis and mastalgia.
  
  
  METHODS
  Fifty one patients with mastalgia/fibroadenosis were treated with centchroman 30mg once daily on alternate days for a period of 3 months and followed up weekly for six months with Mastalgia chart and Visual Analog Scale (VAS) pain score.
  
  
  RESULTS
  Before starting treatment, four patients presented with pain score of 6 followed by, 37 patients with a score of 4 and 10 patients with a score of 2. All the patients were started on tab centchroman 30mg OD alternate days and were reviewed on weekly basis with Mastalgia chart and VAS pain score for three months. On fifth and sixth visit, 46 patients reported with pain score 0, one with pain score of 2 and four with pain score of 6. The efficacy of centchroman was found to be significant (p-value = 0.001). Three patients (5.9%) reported epigastric pain and ten patients (19.6%) reported menstrual delay. A total of 38 patients did not complain of any side effect.
  
  
  CONCLUSIONS
  Our study proves that centchroman is a safe and cost effective drug with significant efficacy on regression of fibroadenosis and mastalgia with minimal side effect.
authors.affiliation: Resident, Department of General Surgery, Mahatma Gandhi Medical College and Research Institute, Sri Balaji Vidyapeeth , Pillaiyarkuppam, Pondicherry, India .
authors.forename: Udayakumar
authors.initials: U
authors.lastname: Rajswaroob
authors.affiliation: Associate Professor, Department of General Surgery, Mahatma Gandhi Medical College and Research Institute, Sri Balaji Vidyapeeth , Pillaiyarkuppam, Pondicherry, India .
authors.forename: Rajendiran
authors.initials: R
authors.lastname: Kannan
authors.affiliation: Associate Professor, Department of General Surgery, Mahatma Gandhi Medical College and Research Institute, Sri Balaji Vidyapeeth , Pillaiyarkuppam, Pondicherry, India .
authors.forename: Narayanasamy Subbaraju
authors.initials: NS
authors.lastname: Kannan
authors.affiliation: Professor and Head, Department of General Surgery, Mahatma Gandhi Medical College and Research Institute, Sri Balaji Vidyapeeth , Pillaiyarkuppam, Pondicherry, India .
authors.forename: T
authors.initials: T
authors.lastname: Tirouaroul
keywords: Cyclical; Fibroadenoma; Fibrocystic disease; Hormonal therapy; Non-cyclical; Ormeloxifene