title: Magnetic nanoparticles for precision oncology: theranostic magnetic iron oxide nanoparticles for image-guided and targeted cancer therapy.
abstract: Recent advances in the development of magnetic nanoparticles (MNPs) have shown promise in the development of new personalized therapeutic approaches for clinical management of cancer patients. The unique physicochemical properties of MNPs endow them with novel multifunctional capabilities for imaging, drug delivery and therapy, which are referred to as theranostics. To facilitate the translation of those theranostic MNPs into clinical applications, extensive efforts have been made on designing and improving biocompatibility, stability, safety, drug-loading ability, targeted delivery, imaging signal and thermal- or photodynamic response. In this review, we provide an overview of the physicochemical properties, toxicity and theranostic applications of MNPs with a focus on magnetic iron oxide nanoparticles.
authors.affiliation: Departments of Surgery & Radiology & Imaging Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhu
authors.affiliation: Departments of Surgery & Radiology & Imaging Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA.|Xiangya School of Medicine, Central South University, Changsha, Hunan 410008, China.
authors.forename: Zhiyang
authors.initials: Z
authors.lastname: Zhou
authors.affiliation: Departments of Surgery & Radiology & Imaging Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA.
authors.forename: Hui
authors.initials: H
authors.lastname: Mao
authors.affiliation: Departments of Surgery & Radiology & Imaging Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA.
authors.forename: Lily
authors.initials: L
authors.lastname: Yang
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D003287:Contrast Media / Q000737:chemistry; D016503:Drug Delivery Systems; D005290:Ferric Compounds / Q000737:chemistry / Q000627:therapeutic use / Q000633:toxicity; D006801:Humans; D008279:Magnetic Resonance Imaging; D058185:Magnetite Nanoparticles / Q000737:chemistry / Q000627:therapeutic use / Q000633:toxicity; D009369:Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000628:therapy*; D057285:Precision Medicine / Q000379:methods; D013499:Surface Properties; D000068936:Theranostic Nanomedicine
chemical_list: D000970:Antineoplastic Agents; D003287:Contrast Media; D005290:Ferric Compounds; D058185:Magnetite Nanoparticles; C000499:ferric oxide
keywords: iron oxide nanoparticle; magnetic nanoparticles; theranostic