title: [Plasma metabonomics of Guifu Dihuang Wan in the treatment of yang deficiency].
abstract: OBJECTIVE
  To assess the effect of Guifu Dihuang Wan (GFDHW) in the treatment of yang deficiency and explore the underlying molecular mechanism.
  
  
  METHODS
  Sixty-two participants without diseases were randomized into control group (n=31) and experimental group (n=31) and were given lifestyle intervention additional GFDHW treatment for a month. NMR technology was used for metabonomics analysis.
  
  
  RESULTS
  Intervention with GFDHW resulted in significantly decreased conversion scores of yang deficiency in the experimental group compared with the control group (P<0.005). The concentrations of lactate, valine, proline, arginine and 3-hydroxybutyrate were increased in the plasma of yang-deficient subjects after lifestyle intervention. GFDHW treatment with lifestyle intervention significantly increased the concentrations of lactate, valine, proline, arginine and 3-hydroxybutyrate and also the levels of alanine, glutamine, alpha glucose, isoleucine, betaine and propylene glycol.
  
  
  CONCLUSIONS
  GFDHW treatment improves yang deficiency possibly by increasing the concentrations of alanine, glutamine, alpha glucose, isoleucine, betaine and propylene glycol and promoting energy metabolism of the body.
authors.affiliation: School of Traditional Chinese Medicine, Jinan University, Guangzhou 510632, China.E-mail: 404271426@qq.com.
authors.forename: Ya
authors.initials: Y
authors.lastname: Xiao
authors.forename: Yuan
authors.initials: Y
authors.lastname: Jing
authors.forename: Jie-Yu
authors.initials: JY
authors.lastname: Chen
authors.forename: Fei
authors.initials: F
authors.lastname: Li
authors.forename: Jing-Ru
authors.initials: JR
authors.lastname: Cheng
authors.forename: Jian-Lu
authors.initials: JL
authors.lastname: Bi
authors.forename: Ren
authors.initials: R
authors.lastname: Luo
authors.forename: Xiao-Shan
authors.initials: XS
authors.lastname: Zhao
mesh_terms: D020155:3-Hydroxybutyric Acid / Q000097:blood; D001120:Arginine / Q000097:blood; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D006801:Humans; D019344:Lactic Acid / Q000097:blood; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D055432:Metabolomics; D010949:Plasma; D014633:Valine / Q000097:blood; D016711:Yang Deficiency / Q000188:drug therapy*
chemical_list: D004365:Drugs, Chinese Herbal; D019344:Lactic Acid; D001120:Arginine; D014633:Valine; D020155:3-Hydroxybutyric Acid