title: The TRANSPLANTEX initiative.
abstract: TRANSPLANTEX, a French "investment for the future" initiated consortium of leading transplant units and research laboratories across France and a number of European countries aims to unravel, through mainly high-throughput genomics (and other omics) analyses of donor and recipients, novel (a) non-HLA, histocompatibility antigens, whether inside, or outside the MHC; (b) pre/post transplantation biomarkers. This shall lead to our better understanding of the pathophysiology of (and eventually designing better therapeutics for) the graft-versus-host disease in hematopoietic cell transplants and that of chronic graft rejection after kidney transplant. Industrial developments as well as innovative teaching initiatives are also integral part of this program. The present issue of Human Immunology aims to present a first snapshot of some of the research performed by TRANPLANTEX partners.
authors.affiliation: LabEx TRANSPLANTEX; Laboratoire d'ImmunoRhumatologie Moléculaire, INSERM UMR_S1109, Centre de Recherche d'Immunologie et d'Hématologie, Faculté de Médecine, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg, 67085 Strasbourg Cedex, France; INSERM Franco-Japanese Nextgen HLA Laboratory (FJ-HLA), Laboratoire International Associé (LIA), 67000 Strasbourg, France; Fédération Hospitalo-Universitaire, OMICARE, Centre de Recherche d'Immunologie et d'Hématologie, 67085 Strasbourg Cedex, France; Laboratoire d'Immunologie, Plateau Technique de Biologie, Pôle de Biologie, Nouvel Hôpital Civil, 67091 Strasbourg Cedex, France. Electronic address: siamak@unistra.fr.
authors.forename: Seiamak
authors.initials: S
authors.lastname: Bahram
authors.affiliation: LabEx TRANSPLANTEX; Laboratoire d'ImmunoRhumatologie Moléculaire, INSERM UMR_S1109, Centre de Recherche d'Immunologie et d'Hématologie, Faculté de Médecine, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg, 67085 Strasbourg Cedex, France; INSERM Franco-Japanese Nextgen HLA Laboratory (FJ-HLA), Laboratoire International Associé (LIA), 67000 Strasbourg, France; Fédération Hospitalo-Universitaire, OMICARE, Centre de Recherche d'Immunologie et d'Hématologie, 67085 Strasbourg Cedex, France; Laboratoire d'Immunologie, Plateau Technique de Biologie, Pôle de Biologie, Nouvel Hôpital Civil, 67091 Strasbourg Cedex, France.
authors.forename: Raphael
authors.initials: R
authors.lastname: Carapito
authors.affiliation: LabEx TRANSPLANTEX, CHU de Nantes, ATIP-Avenir Team, ITUN-CRTI-UMR Inserm 1064 - Hospital and University of Nantes, 44000, France; Department of Neurology, University of California, San Francisco, CA 94117, USA.
authors.forename: Pierre-Antoine
authors.initials: PA
authors.lastname: Gourraud
authors.affiliation: LabEx TRANSPLANTEX; HLA & Médecine "Jean Dausset" Laboratory Network, Hôpital Saint-Louis AP-HP, Université Paris Diderot, 75013, France; JiaoTong University, Rujin Hospital Shanghai, China.
authors.forename: Dominique
authors.initials: D
authors.lastname: Charron
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D032921:Consensus; D005602:France; D006084:Graft Rejection / Q000175:diagnosis / Q000517:prevention & control*; D006086:Graft vs Host Disease / Q000175:diagnosis / Q000628:therapy*; D006650:Histocompatibility Testing; D006801:Humans; D007165:Immunosuppression Therapy; D016030:Kidney Transplantation; D012042:Registries
chemical_list: D015415:Biomarkers