title: When to Suspect Autoinflammatory/Recurrent Fever Syndromes.
abstract: Autoinflammatory disorders are disorders characterized by rash, arthritis, fever, and systemic inflammation. These disorders are caused by mutations in genes important in innate immune system sensors. This review highlights the workup of an individual with recurrent episodes of inflammation, features of these disorders, the genetic defects that cause these disorders, and the specific treatments available.
authors.affiliation: Pediatric Rheumatology, Medical College of Wisconsin, Children's Corporate Center, Suite C465, 9000 West Wisconsin Avenue, PO Box 1997, Milwaukee, WI 53201-1997, USA. Electronic address: jverbsky@mcw.edu.
authors.forename: James W
authors.initials: JW
authors.lastname: Verbsky
mesh_terms: D002648:Child; D057210:Delayed Diagnosis; D003937:Diagnosis, Differential; D003951:Diagnostic Errors; D005334:Fever; D056660:Hereditary Autoinflammatory Diseases / Q000175:diagnosis* / Q000235:genetics / Q000276:immunology* / Q000628:therapy; D006801:Humans; D007113:Immunity, Innate; D035583:Rare Diseases / Q000175:diagnosis / Q000235:genetics / Q000276:immunology / Q000628:therapy; D012008:Recurrence; D013577:Syndrome
keywords: Autoinflammatory; Fever; IL-1beta; Innate immunity; TNF-α