title: Therapeutic effects of sequential chemoradiotherapy with pemetrexed and cisplatin on locally advanced laryngeal cancer.
abstract: OBJECTIVE
  To explore the therapeutic effects of sequential chemoradiotherapy with pemetrexed and cisplatin on locally advanced laryngeal cancer (LALC).
  
  
  METHODS
  Fifty LALC patients who were treated in our hospital between January 2010 and January 2012 were selected and randomly divided into an observation group and a control group (n=25). The two groups were given conventional radiotherapy in the same manner, before which two cycles of chemotherapy were performed. The observation group intravenously infused with 500 mg/m2pemetrexed on d1 and 25 mg/m2cisplatin on d1-3, with 28 days as a cycle. The control group was intravenously infused with 25 mg/m2cisplatin on d1-3 and 400 mg/m2fluorouracil, with 28 days as a cycle. The short-term effects and adverse reactions of both groups were observed after treatment, and their survival was observed by follow-up for five years.
  
  
  RESULTS
  The response rate was 84% (21/25) in the observation group and 64% (16/25) in the control group, between which the difference was statistically significant (P<0.05). The differences in the incidence rates of short-term adverse reactions such as grade III-IV gastrointestinal reactions and bone marrow suppression were not statistically significant between PC regimen (pemetrexed combined with cisplatin) and PF regimen (cisplatin combined with fluorouracil) (P>0.05). The incidence of long-term adverse reactions such as grade III-IV laryngeal edemas, laryngeal cartilage inflammation and laryngeal cartilage necrosis showed no significant differences between the two groups (P>0.05). The median survival was 3.3 years after PC chemotherapy and 2.8 years after PF chemotherapy, between which the difference was not statistically significant (P>0.05). The levels of serum tumor markers significantly decreased after PC and PF treatments compared with those before (P<0.05).
  
  
  CONCLUSIONS
  Combining PC chemotherapy with radiotherapy has satisfactory short-term therapeutic effects on LALC, and the resulting adverse effects can be tolerated. Therefore, this strategy is worthy of promotion and application in clinical practice.
authors.affiliation: Youmao Tao, China-Japan Union Hospital, Jilin University, Changchun 130033, China.
authors.forename: Youmao
authors.initials: Y
authors.lastname: Tao
authors.affiliation: Chong Ma, China-Japan Union Hospital, Jilin University, Changchun 130033, China.
authors.forename: Chong
authors.initials: C
authors.lastname: Ma
authors.affiliation: Xiangdang Yin, Jilin Cancer Hospital, Changchun 130001, China.
authors.forename: Xiangdang
authors.initials: X
authors.lastname: Yin
authors.affiliation: Xuedong Fang, China-Japan Union Hospital, Jilin University, Changchun 130033, China.
authors.forename: Xuedong
authors.initials: X
authors.lastname: Fang
authors.affiliation: Lixiu Liu, China-Japan Union Hospital, Jilin University, Changchun 130033, China.
authors.forename: Lixiu
authors.initials: L
authors.lastname: Liu
keywords: Chemoradiotherapy; Cisplatin; Laryngeal cancer; Pemetrexed