title: Sjögren Syndrome and Other Causes of Sicca in Older Adults.
abstract: Dry eye and dry mouth symptoms are each reported by up to 30% of persons more than 65 years of age, particularly in women. Medication side effects are the most common contributing factors. The evaluation of these symptoms requires measures of ocular and oral dryness. Sjögren syndrome is the prototypic disease associated with dryness of the eyes and mouth and predominantly affects women in their perimenopausal and postmenopausal years. In addition to topical treatment of the mucosal dryness, patients with Sjögren syndrome may require treatment with systemic immunomodulatory and immunosuppressive agents to manage a variety of extraglandular manifestations.
authors.affiliation: Division of Rheumatology, Department of Medicine, Johns Hopkins University School of Medicine, 5200 Eastern Avenue, Suite 4000, Mason Lord Center Tower, Baltimore, MD 21224, USA; National Institute of Dental and Craniofacial Research, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA. Electronic address: alanbaer@jhmi.edu.
authors.forename: Alan N
authors.initials: AN
authors.lastname: Baer
authors.affiliation: National Institute of Dental and Craniofacial Research, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA.
authors.forename: Brian
authors.initials: B
authors.lastname: Walitt
mesh_terms: D000368:Aged; D001323:Autoantibodies / Q000276:immunology*; D015551:Autoimmunity; D001706:Biopsy; D015352:Dry Eye Syndromes / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D012859:Sjogren's Syndrome / Q000150:complications / Q000175:diagnosis / Q000276:immunology; D014987:Xerostomia / Q000175:diagnosis / Q000209:etiology / Q000276:immunology
chemical_list: D001323:Autoantibodies
keywords: Aging; Dry eye; Salivary hypofunction; Sjögren syndrome; Xerostomia