title: [A cohort study of HIV incidence among injecting drug users in Dehong Prefecture, Yunnan Province].
abstract: Objective:To investigate the incidence rates of HIV among injection drug users (IDU) in Dehong Prefecture, Yunnan Province.Methods:We recruited 1 413 HIV-negative IDU attending drug rehabilitation centers and identified a further 1 830 potential participants from a historical database from 2004-2009 using the same criteria. Fingerprint recognition technology was used to confirm the identity of all participants. A total of 3 243 HIV-negative IDU were recruited by the end of 2015, of which 2 546 (78.5%) had been followed up at least once since the initial data collection and 697 (21.5%) were lost to follow-up. Epidemiological data were collected through structured face-to-face interviews which included items on knowledge of AIDS, drug use, sexual activity and history of HIV testing. We collected 3-5 ml of venous blood from each subject for HIV testing. The Chi-squared test was used to compare the characteristics of those IDUs successfully followed up and those lost to follow-up.Results:We identified 226 new HIV cases among the 2 546 respondents-representing 13 907.1 person-years of follow-up and implying an average HIV incidence rate of 1.6 per 100 person-years over the entire study period (95%CI:1.4-1.9). The incidence rate (per 100 person-years) was 2.6 (95%CI: 2.2-3.1) for the period 2004-2009 and 1.6 (95%CI: 1.0-2.3), 1.7 (95%CI: 1.1-2.4), 1.2 (95%CI: 0.8-1.9), 0.6 (95%CI: 0.3-1.1), 0.2 (95%CI:0.0-0.7), 0.5 (95%CI: 0.1-1.4) for each year from 2010 to 2015 respectively.Conclusion:Although the incidence rate of HIV remains high among IDUs in Dehong, there was a declining trend over the period studied.
authors.affiliation: Department of STD/AIDS Prevention and Control, Dehong Prefecture Center for Disease Control and Prevention, Mangshi, Yunnan Province, Mangshi 678400, China.
authors.forename: Y C
authors.initials: YC
authors.lastname: Yang
authors.affiliation: Department of Epidemiology at School of Public Health and the Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai 200032, China.
authors.forename: Z Y
authors.initials: ZY
authors.lastname: Jin
authors.forename: R H
authors.initials: RH
authors.lastname: Tang
authors.forename: L
authors.initials: L
authors.lastname: Li
authors.forename: R H
authors.initials: RH
authors.lastname: Ye
authors.forename: Y F
authors.initials: YF
authors.lastname: Cao
authors.forename: S J
authors.initials: SJ
authors.lastname: Yang
authors.forename: S T
authors.initials: ST
authors.lastname: Yao
authors.forename: S
authors.initials: S
authors.lastname: Duan
authors.forename: N
authors.initials: N
authors.lastname: He
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000453:epidemiology*; D000328:Adult; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D055030:Drug Users; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology*; D015497:HIV-1; D006801:Humans; D015994:Incidence; D008297:Male; D008403:Mass Screening; D012047:Rehabilitation Centers; D012725:Sexual Behavior; D015819:Substance Abuse, Intravenous / Q000453:epidemiology* / Q000821:virology*; D011795:Surveys and Questionnaires