title: Maternal Lipids May Predict Fetal Growth in Type 2 Diabetes Mellitus and Gestational Diabetes Mellitus Pregnancies.
abstract: OBJECTIVE
  During diabetic pregnancy, complex metabolic changes occur in the lipid profile. The aim of the study was to determine the predictive values of maternal serum lipid levels on large-for-gestational age newborns during the third trimester in pregnancies of women with type 2 diabetes mellitus (DM2) and gestational diabetes mellitus (GDM).
  
  
  METHODS
  Data of forty three pregnancies of women with DM2 and two hundred women with GDM were analyzed. The analysis encompassed the following parameters: age, body mass index (BMI), lipid parameters, HbA1c in first, second and third trimester of pregnancy, preeclampsia and baby birth weight.
  
  
  RESULTS
  DM2 and GDM groups showed statistically significant differences in the following variables: total lipids, triglycerides, total cholesterol, BMI, age, baby birth weight, incidence of SGA and preterm delivery (9.4 ± 2.3 vs. 11.0 ± 2.3 mmol/L, 2.4 ± 1.4 vs. 3.4 ± 1.6 mmol/L, 5.5 ± 1.2 vs. 6.4 ± 1.4 mmol/L, 30.6 ± 5.4 vs. 26.9 ± 5.2 kg/m2, 34 ± 7.8 vs. 31.5 ± 5.6 years, 3183 ± 972 vs. 3533 ± 699 g., 20% vs. 7.5%, 27.9 vs. 14%, respectively, p < 0.05). Linear multiple regression analysis demonstrated that triglycerides, LDL-C and total cholesterol were independent predictors of LGA (p < 0.05).
  
  
  CONCLUSIONS
  Triglycerides and LDL-C in the third trimester of pregnancy are independent predictors for fetal macrosomia in DM2 and GDM pregnancies. Thus, the maternal serum triglycerides and LDL-C levels determined in the maternal blood taken in the third trimester of pregnancy may indentify women who will give birth to LGA newborns.
authors.forename: Brankica
authors.initials: B
authors.lastname: Krstevska
authors.forename: Sasha Misevska
authors.initials: SM
authors.lastname: Jovanovska
authors.forename: Slagjana Simeonova
authors.initials: SS
authors.lastname: Krstevska
authors.forename: Valentina Velkoska
authors.initials: VV
authors.lastname: Nakova
authors.forename: Vladimir
authors.initials: V
authors.lastname: Serafimoski
mesh_terms: D000328:Adult; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications; D016640:Diabetes, Gestational / Q000097:blood* / Q000209:etiology; D005260:Female; D005320:Fetal Macrosomia / Q000097:blood* / Q000209:etiology*; D006801:Humans; D007231:Infant, Newborn; D008055:Lipids / Q000097:blood*; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000097:blood* / Q000209:etiology; D012189:Retrospective Studies
chemical_list: D008055:Lipids