title: Comparison of Lower Extremity Endovascular Intervention Outcomes in Women Versus Men.
abstract: This study examined a gender difference in 12-month patient outcomes after endovascular intervention for symptomatic peripheral artery disease (PAD) utilizing propensity score-matched Excellence in Peripheral Artery Disease registry data. Mortality and repeat intervention outcomes after endovascular treatment in women compared with men in the existing literature are inconsistent and confounded by other risk factors. The study included 1,084 patients who underwent 1,702 endovascular procedures, at 8 non-Veterans Administration hospitals from January 2005 to October 2015. Frailty hazard ratios by gender for time-to-event analysis were estimated. Women made up about 40% of the study population. After propensity score matching, 449 women and 449 men were included in the analysis, in which women had similar baseline patient and lesion characteristics, laboratory data, procedural characteristics, and medical therapy as men. Within 12-month postintervention, women were at a lower risk of mortality than men (p = 0.05); however, they underwent significantly more frequent repeat revascularization procedures (p = 0.04). In subgroup analysis, women with superficial femoral artery disease were also at higher risk of 12-month repeat intervention than men (p <0.01) and had a higher mortality risk, albeit with an attenuated significance (p = 0.07). Women with PAD are at a higher risk of 12-month repeat intervention than men.
authors.affiliation: Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas; North Texas Veterans Administration Hospital, Dallas, Texas.
authors.forename: Haekyung
authors.initials: H
authors.lastname: Jeon-Slaughter
authors.affiliation: Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas; Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas.
authors.forename: Shirling
authors.initials: S
authors.lastname: Tsai
authors.affiliation: Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas; North Texas Veterans Administration Hospital, Dallas, Texas.
authors.forename: Preeti
authors.initials: P
authors.lastname: Kamath
authors.affiliation: Midwest Cardiovascular Research Foundation, Davenport, Iowa.
authors.forename: Nicolas W
authors.initials: NW
authors.lastname: Shammas
authors.affiliation: Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas; North Texas Veterans Administration Hospital, Dallas, Texas.
authors.forename: Emmanouil S
authors.initials: ES
authors.lastname: Brilakis
authors.affiliation: Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas; North Texas Veterans Administration Hospital, Dallas, Texas. Electronic address: subhash.banerjee@utsouthwestern.edu.
authors.forename: Subhash
authors.initials: S
authors.lastname: Banerjee
mesh_terms: D000368:Aged; D057510:Endovascular Procedures; D005260:Female; D005263:Femoral Artery / Q000601:surgery*; D006801:Humans; D035002:Lower Extremity; D008297:Male; D008875:Middle Aged; D009026:Mortality; D058729:Peripheral Arterial Disease / Q000601:surgery*; D011150:Popliteal Artery / Q000601:surgery*; D057216:Propensity Score; D016016:Proportional Hazards Models; D012042:Registries; D012086:Reoperation; D012737:Sex Factors; D016909:Tibial Arteries / Q000601:surgery*