title: Clinical relevance of endoscopic assessment of inflammation in ulcerative colitis: Can endoscopic evaluation predict outcomes?
abstract: Ulcerative colitis (UC) is a chronic inflammatory bowel condition characterised by a relapsing and remitting course. Symptom control has been the traditional mainstay of medical treatment. It is well known that histological inflammatory activity persists despite adequate symptom control and absence of endoscopic inflammation. Current evidence suggests that presence of histological inflammation poses a greater risk of disease relapse and subsequent colorectal cancer risk. New endoscopic technologies hold promise for developing endoscopic markers of mucosal inflammation. Achieving endoscopic and histological remission appears be the future aim of medical treatments for UC. This review article aims to evaluate the use of endoscopy as a tool in assessment of mucosal inflammation UC and its correlation with disease outcomes.
authors.affiliation: Noor Mohammed, Venkataraman Subramanian, Leeds Institute of Biomedical and Clinical Sciences, St James University Hospital, University of Leeds, Leeds LS2 9JT, United Kingdom.
authors.forename: Noor
authors.initials: N
authors.lastname: Mohammed
authors.affiliation: Noor Mohammed, Venkataraman Subramanian, Leeds Institute of Biomedical and Clinical Sciences, St James University Hospital, University of Leeds, Leeds LS2 9JT, United Kingdom.
authors.forename: Venkataraman
authors.initials: V
authors.lastname: Subramanian
mesh_terms: D003093:Colitis, Ulcerative / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D003106:Colon / Q000473:pathology*; D003113:Colonoscopy; D006801:Humans; D007413:Intestinal Mucosa / Q000473:pathology*; D011237:Predictive Value of Tests; D012008:Recurrence; D012074:Remission Induction; D012307:Risk Factors; D012720:Severity of Illness Index; D016896:Treatment Outcome; D014945:Wound Healing
keywords: Disease activity indices; Endoscopy; Inflammation; Mucosal healing; Ulcerative colitis