title: Satellite cell activation induced by aerobic muscle adaptation in response to endurance exercise in humans and rodents.
abstract: Although the requirement of satellite cells activation and expansion following injury, mechanical load or growth stimulus provoked by resistance exercise has been well established, their function in response to aerobic exercise adaptation remains unclear. A clear relationship between satellite cell expansion in fiber-type specific myosin heavy chain and aerobic performance has been related, independent of myonuclear accretion or muscle growth. However, the trigger for this activation process is not fully understood yet and it seems to be a multi-faceted and well-orchestrated process. Emerging in vitro studies suggest a role for metabolic pathways and oxygen availability for satellite cell activation, modulating the self-renewal potential and cell fate control. The goal of this review is to describe and discuss the current knowledge about the satellite cell activation and expansion in response to aerobic exercise adaptation in human and rodent models. Additionally, findings about the in vitro metabolic control, which seems be involved in the satellite cell activation and cell fate control, are presented and discussed.
authors.affiliation: Institute of Biomedical Sciences, University of Sao Paulo, SP, Brazil; Institute of Biomedical Sciences, State University of Ceará, CE, Brazil. Electronic address: phablo@icb.usp.br.
authors.forename: Phablo
authors.initials: P
authors.lastname: Abreu
authors.affiliation: Institute of Biomedical Sciences, State University of Ceará, CE, Brazil.
authors.forename: Sávio Victor Diógenes
authors.initials: SV
authors.lastname: Mendes
authors.affiliation: Institute of Biomedical Sciences, State University of Ceará, CE, Brazil.
authors.forename: Vânia Marilande
authors.initials: VM
authors.lastname: Ceccatto
authors.affiliation: Institute of Biomedical Sciences, University of Sao Paulo, SP, Brazil; Institute of Physical Activity Sciences and Sports, Cruzeiro do Sul University, Sao Paulo, SP, Brazil.
authors.forename: Sandro Massao
authors.initials: SM
authors.lastname: Hirabara
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D002453:Cell Cycle; D019070:Cell Lineage; D015444:Exercise / Q000502:physiology*; D006801:Humans; D051379:Mice; D008810:Mice, Inbred C57BL; D024510:Muscle Development; D018485:Muscle Fibers, Skeletal / Q000502:physiology*; D018482:Muscle, Skeletal / Q000502:physiology*; D032446:Myoblasts / Q000502:physiology; D018995:Myosin Heavy Chains / Q000737:chemistry; D010100:Oxygen / Q000737:chemistry; D010805:Physical Conditioning, Animal; D010807:Physical Endurance; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D018995:Myosin Heavy Chains; D010100:Oxygen
keywords: Endurance exercise; Satellite cells activation; Skeletal muscle