title: Copper-Catalyzed Alkoxycarbonylation of Alkanes with Alcohols.
abstract: Esters are important chemicals widely used in various areas, and alkoxycarbonylation represents one of the most powerful tools for their synthesis. In this communication, a new copper-catalyzed carbonylative procedure for the synthesis of aliphatic esters from cycloalkanes and alcohols was developed. Through direct activation of the Csp3 -H bond of alkanes and with alcohols as the nucleophiles, the desired esters were prepared in moderate-to-good yields. Paraformaldehyde could also be applied for in situ alcohol generation by radical trapping, and moderate yields of the corresponding esters could be produced. Notably, this is the first report on copper-catalyzed alkoxycarbonylation of alkanes.
authors.affiliation: Leibniz-Institut für Katalyse e.V. an der, Universität Rostock, Albert-Einstein-Straße 29a, 18059, Rostock, Germany.
authors.forename: Yahui
authors.initials: Y
authors.lastname: Li
authors.affiliation: Catalyse et Organométalliques, Institut Sciences Chimiques de Rennes, UMR 6226-CNRS-Université de Rennes, Av. Général Leclerc, 35042, Rennes, France.
authors.forename: Changsheng
authors.initials: C
authors.lastname: Wang
authors.affiliation: Leibniz-Institut für Katalyse e.V. an der, Universität Rostock, Albert-Einstein-Straße 29a, 18059, Rostock, Germany.
authors.forename: Fengxiang
authors.initials: F
authors.lastname: Zhu
authors.affiliation: Leibniz-Institut für Katalyse e.V. an der, Universität Rostock, Albert-Einstein-Straße 29a, 18059, Rostock, Germany.
authors.forename: Zechao
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Catalyse et Organométalliques, Institut Sciences Chimiques de Rennes, UMR 6226-CNRS-Université de Rennes, Av. Général Leclerc, 35042, Rennes, France.
authors.forename: Pierre H
authors.initials: PH
authors.lastname: Dixneuf
authors.affiliation: Leibniz-Institut für Katalyse e.V. an der, Universität Rostock, Albert-Einstein-Straße 29a, 18059, Rostock, Germany.
authors.forename: Xiao-Feng
authors.initials: XF
authors.lastname: Wu
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D000473:Alkanes / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D004952:Esters / Q000138:chemical synthesis / Q000737:chemistry; D007659:Ketones / Q000737:chemistry; D010165:Palladium / Q000737:chemistry
chemical_list: D000438:Alcohols; D000473:Alkanes; D004952:Esters; D007659:Ketones; D010165:Palladium; D003300:Copper
keywords: alcohols; alkanes; carbonylation; copper catalyst; esters