title: Relative Strand Orientation in a DNA Duplex Controls the Nuclearity of a Metal-Mediated Base Pair.
abstract: 1,N6-Ethenoadenine (ϵA) and cytosine (C) are able to form two different metal-mediated base pairs. When the glycosidic bonds are arranged in a cisoid manner (i.e., in antiparallel-stranded DNA), the ϵA:C mispair binds one AgIion, leading to a mononuclear ϵA-AgI-C base pair that contains a synergistic hydrogen bond. In contrast, a transoid orientation of the glycosidic bonds (as found in parallel-stranded DNA) results in the formation of a dinuclear metal-mediated base pair ϵA-AgI2-C.
authors.affiliation: Institut für Anorganische und Analytische Chemie, Westfälische Wilhelms-Universität Münster, Corrensstraße 28/30, 48149, Münster, Germany.|NRW Graduate School of Chemistry, Westfälische Wilhelms-Universität Münster, Corrensstraße 28/30, 48149, Münster, Germany.
authors.forename: Soham
authors.initials: S
authors.lastname: Mandal
authors.affiliation: Institut für Anorganische und Analytische Chemie, Westfälische Wilhelms-Universität Münster, Corrensstraße 28/30, 48149, Münster, Germany.
authors.forename: Marian
authors.initials: M
authors.lastname: Hebenbrock
authors.affiliation: Institut für Anorganische und Analytische Chemie, Westfälische Wilhelms-Universität Münster, Corrensstraße 28/30, 48149, Münster, Germany.|NRW Graduate School of Chemistry, Westfälische Wilhelms-Universität Münster, Corrensstraße 28/30, 48149, Münster, Germany.
authors.forename: Jens
authors.identifier: http://orcid.org/0000-0003-4713-0606
authors.initials: J
authors.lastname: Müller
mesh_terms: D000225:Adenine / Q000737:chemistry; D020029:Base Pairing; D001483:Base Sequence; D002942:Circular Dichroism; D003596:Cytosine / Q000737:chemistry / Q000378:metabolism; D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D006860:Hydrogen Bonding; D009690:Nucleic Acid Conformation; D012834:Silver / Q000737:chemistry* / Q000378:metabolism; D013816:Thermodynamics; D044366:Transition Temperature
chemical_list: D012834:Silver; D003596:Cytosine; D004247:DNA; D000225:Adenine
keywords: DNA; bioconjugates; bioinorganic chemistry; nucleotides; parallel-stranded DNA