title: Thermohydrogel Containing Melanin for Photothermal Cancer Therapy.
abstract: Melanin is an effective absorber of light and can extend to near infrared (NIR) regions. In this study, a natural melanin is presented as a photothermal therapeutic agent (PTA) because it provides a good photothermal conversion efficiency, shows biodegradability, and does not induce long-term toxicity during retention in vivo. Poloxamer solution containing melanin (Pol-Mel) does not show any precipitation and shows sol-gel transition at body temperature. After irradiation from 808 nm NIR laser at 1.5 W cm-2for 3 min, the photothermal conversion efficiency of Pol-Mel is enough to kill cancer cells in vitro and in vivo. The tumor growth of mice bearing CT26 tumors treated with Pol-Mel injection and laser irradiation is suppressed completely without recurrence postirradiation. All these results indicate that Pol-Mel can become an attractive PTA for photothermal cancer therapy.
authors.affiliation: Interdisciplinary Program of Bioelectric Medicine and Department of Biomedical Engineering, Chonnam National University, Yeosu, Jeonnam, 59662, Republic of Korea.
authors.forename: Miri
authors.initials: M
authors.lastname: Kim
authors.affiliation: Department of Nuclear Medicine, Chonbuk National University Medical School, Jeonju, Jeonbuk, 54887, Republic of Korea.
authors.forename: Hyun Soo
authors.initials: HS
authors.lastname: Kim
authors.affiliation: Interdisciplinary Program of Bioelectric Medicine and Department of Biomedical Engineering, Chonnam National University, Yeosu, Jeonnam, 59662, Republic of Korea.
authors.forename: Min Ah
authors.initials: MA
authors.lastname: Kim
authors.affiliation: Department of Nuclear Medicine, Chonbuk National University Medical School, Jeonju, Jeonbuk, 54887, Republic of Korea.
authors.forename: Hyanghwa
authors.initials: H
authors.lastname: Ryu
authors.affiliation: Department of Nuclear Medicine, Chonbuk National University Medical School, Jeonju, Jeonbuk, 54887, Republic of Korea.
authors.forename: Hwan-Jeong
authors.initials: HJ
authors.lastname: Jeong
authors.affiliation: Interdisciplinary Program of Bioelectric Medicine and Department of Biomedical Engineering, Chonnam National University, Yeosu, Jeonnam, 59662, Republic of Korea.
authors.forename: Chang-Moon
authors.initials: CM
authors.lastname: Lee
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D006801:Humans; D020100:Hydrogels / Q000737:chemistry*; D006979:Hyperthermia, Induced / Q000379:methods*; D007259:Infrared Rays; D008297:Male; D008543:Melanins / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D051379:Mice; D008807:Mice, Inbred BALB C; D009369:Neoplasms / Q000628:therapy*; D010789:Phototherapy / Q000379:methods*; D020442:Poloxamer; D023041:Xenograft Model Antitumor Assays
chemical_list: D020100:Hydrogels; D008543:Melanins; D020442:Poloxamer
keywords: cancer therapy; melanin; photothermal therapy; poloxamer; thermohydrogel