title: Influence of a Shorter Duration of Post-Operative Antibiotic Prophylaxis on Infectious Complications in Patients Undergoing Elective Liver Resection.
abstract: BACKGROUND
  Antibiotic prophylaxis has been recommended to reduce post-operative infectious complications. Discontinuation of post-operative antibiotic administration within 24 hours of operation is currently recommended. Many surgeons, however, conventionally tend to extend the duration of prophylactic antibiotic use. In this study, we performed a retrospective analysis to assess the efficacy of extended post-operative antibiotic use in patients who underwent elective liver resection.
  
  
  METHODS
  A total of 208 consecutive patients who underwent liver resection without biliary reconstruction were investigated. Patients were divided into two groups according to the duration of post-operative antibiotic use: Only once after the operation (the post-operative day [POD] 0 group) and until three days after the operation (the POD 3 group). Post-operative complications in the two groups were analyzed and compared.
  
  
  RESULTS
  Incisional surgical site infections (SSIs) were observed in 5% of the POD 0 group and 3% of the POD 3 group (p = 0.517). Organ/space SSIs were observed in 2% of the POD 0 group and 3% of the POD 3 group (p = 0.694). Overall infectious complications including SSIs and remote site infections were observed in 12% of the POD 0 group and 11% of the POD 3 group. Multi-variable analyses revealed that the short-term post-operative antibiotic regimen did not confer additional risk for infectious complications.
  
  
  CONCLUSIONS
  In elective liver resection, the administration of prophylactic antibiotics on the operative day alone appears to be sufficient, because no additional benefit in the incidence of post-operative infectious complications was conferred on patients given antibiotic agents for three days.
authors.affiliation: 1 Department of Digestive Surgery, Breast and Thyroid Surgery, Kagoshima University School of Medicine , Kagoshima, Japan .
authors.forename: Masahiko
authors.initials: M
authors.lastname: Sakoda
authors.affiliation: 1 Department of Digestive Surgery, Breast and Thyroid Surgery, Kagoshima University School of Medicine , Kagoshima, Japan .
authors.forename: Satoshi
authors.initials: S
authors.lastname: Iino
authors.affiliation: 1 Department of Digestive Surgery, Breast and Thyroid Surgery, Kagoshima University School of Medicine , Kagoshima, Japan .
authors.forename: Yuko
authors.initials: Y
authors.lastname: Mataki
authors.affiliation: 1 Department of Digestive Surgery, Breast and Thyroid Surgery, Kagoshima University School of Medicine , Kagoshima, Japan .
authors.forename: Yota
authors.initials: Y
authors.lastname: Kawasaki
authors.affiliation: 1 Department of Digestive Surgery, Breast and Thyroid Surgery, Kagoshima University School of Medicine , Kagoshima, Japan .
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kurahara
authors.affiliation: 1 Department of Digestive Surgery, Breast and Thyroid Surgery, Kagoshima University School of Medicine , Kagoshima, Japan .
authors.forename: Kosei
authors.initials: K
authors.lastname: Maemura
authors.affiliation: 2 Department of Clinical Oncology, Kagoshima University School of Medicine , Kagoshima, Japan .
authors.forename: Shinichi
authors.initials: S
authors.lastname: Ueno
authors.affiliation: 1 Department of Digestive Surgery, Breast and Thyroid Surgery, Kagoshima University School of Medicine , Kagoshima, Japan .
authors.forename: Shoji
authors.initials: S
authors.lastname: Natsugoe
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D019072:Antibiotic Prophylaxis / Q000379:methods / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D008099:Liver / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000453:epidemiology / Q000382:microbiology / Q000517:prevention & control; D012189:Retrospective Studies; D013530:Surgical Wound Infection / Q000453:epidemiology / Q000382:microbiology / Q000517:prevention & control; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents
keywords: antibiotic prophylaxis; liver; post-operative infection; prophylactic antibiotics; surgical site infection