title: Enteropathy-Associated T-Cell Lymphoma.
abstract: Enteropathy-associated T-cell lymphoma is a rare neoplasm with uniformly aggressive features that arises from intestinal T-cells. There is strong evidence supporting its association as a dire complication of celiac disease. The clinical presentation can vary from malabsorption and abdominal pain to an acute abdominal emergency. Originally, it was divided into types I and II in World Health Organization (WHO) classification schemes, reflective of epidemiology and differences in clinicopathologic features. The debate over the degree of separation of the two types is ongoing as new data emerges regarding the pathogenetics. The low incidence and variable patient factors are major barriers in conducting clinical trials and establishing standard treatment regimens. Yet, the collective experience demonstrates favorable outcomes with combination chemotherapy followed by an autologous hematopoietic stem cell transplant in patients who can tolerate such treatment. The prognosis remains dismal; thus, future research studies are warranted to identify effective novel therapies that can improve outcomes in this rare disease entity.
authors.affiliation: Pathology and Laboratory Medicine Institute, Cleveland Clinic, 9500 Euclid Ave, L-30, Cleveland, OH, 44195, USA.
authors.forename: Sarah
authors.initials: S
authors.lastname: Ondrejka
authors.affiliation: Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH, 44195, USA. jagaded@ccf.org.
authors.forename: Deepa
authors.initials: D
authors.lastname: Jagadeesh
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002446:Celiac Disease / Q000150:complications / Q000235:genetics / Q000473:pathology; D002869:Chromosome Aberrations; D003520:Cyclophosphamide / Q000627:therapeutic use; D055050:Diet, Gluten-Free; D004317:Doxorubicin / Q000627:therapeutic use; D058527:Enteropathy-Associated T-Cell Lymphoma / Q000150:complications / Q000188:drug therapy / Q000235:genetics / Q000473:pathology*; D006683:HLA-DQ Antigens / Q000235:genetics; D006801:Humans; D016130:Immunophenotyping; D011241:Prednisone / Q000627:therapeutic use; D011379:Prognosis; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D006683:HLA-DQ Antigens; C053186:HLA-DQ2 antigen; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone
keywords: Celiac disease; Intestinal T-cell lymphoma; Monomorphic CD56+ intestinal T-cell lymphoma; Refractory celiac disease, monomorphic epitheliotropic intestinal T-cell lymphoma; Type I enteropathy-associated T-cell lymphoma; Type II enteropathy-associated T-cell lymphoma