title: Biodegradable nano-polymers as delivery vehicles for therapeutic small non-coding ribonucleic acids.
abstract: Nowadays, small non-coding Ribo Nucleic Acids (sncRNAs) such as siRNA, miRNA and shRNA are extremely serving to gene regulation. They are involved in many biological processes and in an increasing number of studies regarding a variety of application of sncRNAs toward human health and relieving diseases ranging from metabolic disorders to those involving various organ systems as well as different types of cancer. One of the most severe limitations for applying RNA interference technology is the absence of safe and effective carriers for in vivo delivery, including localizing the molecules to a specific site of interest and sustaining the presentation of the payloads for a controlled period of time. In this review, we focus on the sncRNA functions and recent advances on the delivery of these molecules by biodegradable, biocompatible and nontoxic biopolymers including chitosan, cyclodextrins, poly-l-lysine, dextran, poly (lactic co-glycolic acid), polyglutamic acid, hyaluronic acid and gelatin.
authors.affiliation: Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Biotechnology, Higher Education Institute of Rab-Rashid, Tabriz, Iran.
authors.forename: Ahad
authors.initials: A
authors.lastname: Mokhtarzadeh
authors.affiliation: Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Abbas
authors.initials: A
authors.lastname: Alibakhshi
authors.affiliation: Nanotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Hashemi
authors.affiliation: School of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Hejazi
authors.affiliation: Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Vahedeh
authors.initials: V
authors.lastname: Hosseini
authors.affiliation: Department of Analytical Chemistry, University of Valencia, Dr. Moliner 50, 46100 Burjassot, Valencia, Spain. Electronic address: miguel.delaguardia@uv.es.
authors.forename: Miguel
authors.initials: M
authors.lastname: de la Guardia
authors.affiliation: Pharmaceutical Research Center, Department of Pharmaceutical Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Ramezani
mesh_terms: D000818:Animals; D001704:Biopolymers / Q000008:administration & dosage*; D018014:Gene Transfer Techniques; D006801:Humans; D053758:Nanoparticles / Q000008:administration & dosage*; D058727:RNA, Small Untranslated / Q000008:administration & dosage*
chemical_list: D001704:Biopolymers; D058727:RNA, Small Untranslated
keywords: Biocompatible; Biodegradable; Nanopolymer; sncRNA