title: The dbGaP data browser: a new tool for browsing dbGaP controlled-access genomic data.
abstract: The database of Genotypes and Phenotypes (dbGaP) Data Browser (https://www.ncbi.nlm.nih.gov/gap/ddb/) was developed in response to requests from the scientific community for a resource that enable view-only access to summary-level information and individual-level genotype and sequence data associated with phenotypic features maintained in the controlled-access tier of dbGaP. Until now, the dbGaP controlled-access environment required investigators to submit a data access request, wait for Data Access Committee review, download each data set and locally examine them for potentially relevant information. Existing unrestricted-access genomic data browsing resources (e.g. http://evs.gs.washington.edu/EVS/, http://exac.broadinstitute.org/) provide only summary statistics or aggregate allele frequencies. The dbGaP Data Browser serves as a third solution, providing researchers with view-only access to a compilation of individual-level data from general research use (GRU) studies through a simplified controlled-access process. The National Institutes of Health (NIH) will continue to improve the Browser in response to user feedback and believes that this tool may decrease unnecessary download requests, while still facilitating responsible genomic data-sharing.
authors.affiliation: National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20814, USA.
authors.forename: Kira M
authors.initials: KM
authors.lastname: Wong
authors.affiliation: Office of Science Policy, Office of the Director, National Institutes of Health, Bethesda, MD 20814, USA.
authors.forename: Kristofor
authors.initials: K
authors.lastname: Langlais
authors.affiliation: National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
authors.forename: Geoffrey S
authors.initials: GS
authors.lastname: Tobias
authors.affiliation: National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20814, USA.
authors.forename: Colette
authors.initials: C
authors.lastname: Fletcher-Hoppe
authors.affiliation: National Institute of General Medical Sciences, National Institutes of Health, Bethesda, MD 20892, USA.
authors.forename: Donna
authors.initials: D
authors.lastname: Krasnewich
authors.affiliation: Office of Science Policy, Office of the Director, National Institutes of Health, Bethesda, MD 20814, USA.
authors.forename: Hilary S
authors.initials: HS
authors.lastname: Leeds
authors.affiliation: National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20814, USA.
authors.forename: Laura Lyman
authors.initials: LL
authors.lastname: Rodriguez
authors.affiliation: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA.
authors.forename: Georgy
authors.initials: G
authors.lastname: Godynskiy
authors.affiliation: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA.
authors.forename: Valerie A
authors.initials: VA
authors.lastname: Schneider
authors.affiliation: National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20814, USA ramoser@mail.nih.gov.
authors.forename: Erin M
authors.initials: EM
authors.lastname: Ramos
authors.affiliation: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA sherry@ncbi.nlm.nih.gov.
authors.forename: Stephen T
authors.initials: ST
authors.lastname: Sherry
mesh_terms: D019295:Computational Biology / Q000379:methods; D030541:Databases, Genetic; D056726:Genetic Association Studies / Q000379:methods; D023281:Genomics / Q000379:methods*; D005838:Genotype; D010641:Phenotype; D012984:Software; D064878:Web Browser