title: Improvement of Health-Related Quality of Life After Roux-en-Y Gastric Bypass Related to Weight Loss.
abstract: Effect of bariatric surgery on health-related quality of life (HRQOL) varies greatly. This might be caused by the diversity in questionnaires used to assess HRQOL and the weight loss of the studied population. This study assesses the relationship between weight loss and HRQOL in primary Roux-en-Y gastric bypass (RYGB) patients by using an obesity-specific (impact of weight on quality of life-lite, IWQOL-lite) and a generic (RAND-36) questionnaire.
  
  
  
  HRQOL and weight parameters were assessed before and 15 and 24 months after RYGB surgery. HRQOL was assessed by using IWQOL-lite (an obesity-specific questionnaire consisting of one total score and five domains) and RAND-36 (a generic questionnaire consisting of two subtotal scores, the physical health summary (PHS) and mental health summary (MHS), and nine scales).
  
  
  
  Two thousand one hundred thirty-seven patients were included. HRQOL improved significantly after RYGB. Preoperative BMI was negatively related to baseline PHS (p < 0.001) and IWQOL-lite total (p < 0.001). Percentage total weight loss (%TWL) was positively related to HRQOL score at both follow-up moments. Change in HRQOL from baseline to 24 months was related to %TWL at 24 months in both subtotals of RAND-36 and IWQOL-lite total score (p ≤ 0.001 in all).
  
  
  
  HRQOL improves after RYGB. Higher %TWL is related to greater improvement in HRQOL and better HRQOL 15 and 24 months after RYGB. The variance in the effect of RYGB surgery on HRQOL can be explained by the questionnaire used and weight loss of the population.
authors.affiliation: Nederlandse Obesitas Kliniek (Dutch Obesity Clinic), Obesity International, Huis ter Heide, postbus 601, 3700 AP, Zeist, the Netherlands. vmonpellier@obesitaskliniek.nl.|Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, the Netherlands. vmonpellier@obesitaskliniek.nl.
authors.forename: Valerie M
authors.initials: VM
authors.lastname: Monpellier
authors.affiliation: Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, the Netherlands.
authors.forename: Evangelia E
authors.initials: EE
authors.lastname: Antoniou
authors.affiliation: Department of Surgery, Rijnstate Hospital, Arnhem, the Netherlands.
authors.forename: Edo O
authors.initials: EO
authors.lastname: Aarts
authors.affiliation: Nederlandse Obesitas Kliniek (Dutch Obesity Clinic), Obesity International, Huis ter Heide, postbus 601, 3700 AP, Zeist, the Netherlands.|Department of Surgery, Rijnstate Hospital, Arnhem, the Netherlands.
authors.forename: Ignace M C
authors.initials: IMC
authors.lastname: Janssen
authors.affiliation: Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, the Netherlands.
authors.forename: Anita T M
authors.initials: ATM
authors.lastname: Jansen
mesh_terms: D000328:Adult; D050110:Bariatric Surgery; D005260:Female; D015390:Gastric Bypass; D006801:Humans; D008297:Male; D008603:Mental Health; D008875:Middle Aged; D009765:Obesity / Q000601:surgery*; D009767:Obesity, Morbid / Q000601:surgery; D011788:Quality of Life; D012189:Retrospective Studies; D011795:Surveys and Questionnaires; D015431:Weight Loss
keywords: Health-related quality of life; Impact of weight on quality of life-lite; RAND-36; Roux-en-Y gastric bypass; Weight loss