title: Myocardial perfusion and left ventricular quantitative parameters obtained using gated myocardial SPECT: Comparison of three software packages.
abstract: The aim of the present study was to compare Emory Cardiac Toolbox, Myovation, and Quantitative Gated SPECT software regarding the automatic measurements of perfusion and functional left ventricular (LV) quantitative parameters, summed stress score (SSS), perfusion defect score, LV ejection fraction (LVEF), end-diastolic volume, and end-systolic volume (ESV).
  
  
  
  99mTc-tetrofosmin gated SPECT studies were performed in 634 consecutive patients based on the one-day stress/rest protocol. Participants were divided into subgroups according to heart size (ESV cut-off value: 25 mL), perfusion (SSS >/≤3), and other patient/protocol-related factors. LVEF was categorized as normal (≥50%), mildly moderately impaired (35-49%), and severely abnormal (<35%). The concordance between the packages was good to excellent, in overall population, ESV ≤25 mL, ESV >25 mL, and SSS >3 subgroups (intraclass correlation coefficients, ICCs 0.73-0.93). In SSS ≤3 subgroup, the correlation was excellent for LV functional parameters, but suboptimal for perfusion variables (ICCs 0.30-0.83). LVEF categorization revealed similar variability (discordance 18.1 and 11.1% for stress/rest LVEF values, respectively). Pair comparisons demonstrated considerable differences concerning all parameters for all patient subgroups. The statistical significance of our findings by ESV and SSS classifications was evaluated.
  
  
  
  Despite the significant concordance between software packages, considerable differences in mean values of myocardial perfusion and LV functional parameters were demonstrated.
authors.affiliation: Department of Nuclear Medicine, University Hospital of Patras, Patras, Greece. sotalexiou@upatras.gr.|Department of Nuclear Medicine, University Hospital of Larissa, Mezourlo, 41110, Larissa, Thessaly, Greece. sotalexiou@upatras.gr.
authors.forename: Sotiria
authors.initials: S
authors.lastname: Alexiou
authors.affiliation: Department of Nuclear Medicine, University Hospital of Larissa, Mezourlo, 41110, Larissa, Thessaly, Greece.
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Georgoulias
authors.affiliation: Department of Nuclear Medicine, University Hospital of Larissa, Mezourlo, 41110, Larissa, Thessaly, Greece.
authors.forename: George
authors.initials: G
authors.lastname: Angelidis
authors.affiliation: Department of Nuclear Medicine, University Hospital of Larissa, Mezourlo, 41110, Larissa, Thessaly, Greece.
authors.forename: Varvara
authors.initials: V
authors.lastname: Valotassiou
authors.affiliation: Department of Nuclear Medicine, University Hospital of Larissa, Mezourlo, 41110, Larissa, Thessaly, Greece.
authors.forename: Ioannis
authors.initials: I
authors.lastname: Tsougos
authors.affiliation: Department of Nuclear Medicine, University Hospital of Larissa, Mezourlo, 41110, Larissa, Thessaly, Greece.
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Psimadas
authors.affiliation: Department of Nuclear Medicine, University Hospital of Patras, Patras, Greece.
authors.forename: Velissarios
authors.initials: V
authors.lastname: Lakiotis
authors.affiliation: Department of Nuclear Medicine, University Hospital of Patras, Patras, Greece.
authors.forename: Agaristi
authors.initials: A
authors.lastname: Kaspiri
authors.affiliation: Department of Cardiology, University Hospital of Patras, Patras, Greece.
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Alexopoulos
authors.affiliation: Department of Nuclear Medicine, University Hospital of Patras, Patras, Greece.
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Apostolopoulos
authors.affiliation: Department of Nuclear Medicine, University Hospital of Patras, Patras, Greece.
authors.forename: Pavlos
authors.initials: P
authors.lastname: Vassilakos
mesh_terms: D000368:Aged; D000465:Algorithms; D005080:Exercise Test; D005260:Female; D015637:Gated Blood-Pool Imaging; D006801:Humans; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012984:Software; D013318:Stroke Volume / Q000502:physiology; D013667:Technetium; D015899:Tomography, Emission-Computed, Single-Photon; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000503:physiopathology*
chemical_list: D013667:Technetium
keywords: ECTb; Gated SPECT; Myovation; QGS; left ventricular ejection fraction; left ventricular volumes