title: Is Nasal Polyposis Related to Levels of Serum Vitamin D and Vitamin D Receptor Gene Expression?
abstract: BACKGROUND Nasal polyposis (NP) is the most frequent cause of nasal masses. Despite considerable research on the subject, its etiology has not been fully elucidated, and effective treatment methods have not been developed. Some etiological factors causing low or high expression of genes in genetically predisposed individuals may play a role in the pathogenesis of the disease. The purpose of this study was to assess the relation between levels of vitamin D receptor (VDR) gene expression and serum vitamin D with NP. MATERIAL AND METHODS The study included 46 subjects with NP (NP group) and 40 volunteers (control group). Nasal polyp tissue samples were taken from the NP group and nasal mucosa samples were taken from the control group. Levels of VDR gene expression in the tissue samples were assessed using the real-time polymerase chain reaction (RT-PCR) method. RESULTS Mean serum 25(OH)D levels were 13.38±14.08 ng/ml in the NP group and 10.57±6.44 ng/ml in the control group (p=0.249). VDR gene expression was present in 17.5% of the NP group and 3.3% of the control group, and the difference between the 2 groups was statistically significant (likelihood ratio χ²=3.887; p=0.049). CONCLUSIONS This is the first study to assess levels of VDR gene expression in subjects with NP. Our results suggest that VDR gene expression may be associated with the pathogenesis or progression of NP.
authors.affiliation: Department of Otorhinolaryngology, Yuzuncu Yıl University, Faculty of Medicine, Van, Turkey.
authors.forename: Omer
authors.initials: O
authors.lastname: Erdag
authors.affiliation: Department of Otorhinolaryngology, Yuzuncu Yıl University, Faculty of Medicine, Van, Turkey.
authors.forename: Mahfuz
authors.initials: M
authors.lastname: Turan
authors.affiliation: Department of Endocrinology and Metabolism, Yuzuncu Yıl University, Faculty of Medicine, Van, Turkey.
authors.forename: Rıfkı
authors.initials: R
authors.lastname: Ucler
authors.affiliation: Department of Pharmaceutical Biotechnology, Yuzuncu Yıl University, Faculty of Pharmacy, Van, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Berkoz
authors.affiliation: Department of Otorhinolaryngology, Yuzuncu Yıl University, Faculty of Medicine, Van, Turkey.
authors.forename: Mehmet Fatih
authors.initials: MF
authors.lastname: Garca
authors.affiliation: Department of Otorhinolaryngology, Yuzuncu Yıl University, Faculty of Medicine, Van, Turkey.
authors.forename: Nazım
authors.initials: N
authors.lastname: Bozan
authors.affiliation: Department of Otorhinolaryngology, Yuzuncu Yıl University, Faculty of Medicine, Van, Turkey.
authors.forename: Ahmet Faruk
authors.initials: AF
authors.lastname: Kıroglu
authors.affiliation: Department of Otorhinolaryngology, Yuzuncu Yıl University, Faculty of Medicine, Van, Turkey.
authors.forename: Hakan
authors.initials: H
authors.lastname: Cankaya
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D005260:Female; D015870:Gene Expression; D006801:Humans; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa; D009298:Nasal Polyps / Q000097:blood* / Q000235:genetics*; D011446:Prospective Studies; D018167:Receptors, Calcitriol / Q000096:biosynthesis / Q000097:blood / Q000235:genetics* / Q000378:metabolism; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood
chemical_list: D018167:Receptors, Calcitriol; C579457:VDR protein, human; D014807:Vitamin D; C104450:25-hydroxyvitamin D