title: Cucurmin, anticancer, & antitumor perspectives: A comprehensive review.
abstract: Cucurmin, a naturally yellow component isolated from turmeric, ability to prevent various life-style related disorders. The current review article mainly emphasizes on different anticancer perspectives of cucurmin, i.e., colon, cervical, uterine, ovarian, prostate head and neck, breast, pulmonary, stomach and gastric, pancreatic, bladder oral, oesophageal, and bone cancer. It holds a mixture of strong bioactive molecule known as cucurminoids that has ability to reduce cancer/tumor at initial, promotion and progression stages of tumor development. In particular, these compounds block several enzymes required for the growth of tumors and may therefore involve in tumor treatments. Moreover, it modulates an array of cellular progressions, i.e., nitric oxide synthetase activity, protein kinase C activity, epidermal growth factor (EGF) receptor intrinsic kinase activity, nuclear factor kappa (NF-kB) activity, inhibiting lipid peroxidation and production of reactive oxygen species. However, current manuscript summarizes most of the recent investigations of cucurmin but still further research should be conducted to explore the role of curcumin to mitigate various cancers.
authors.affiliation: a Department of Diet and Nutritional Sciences , Imperial College of Business Studies , Lahore , Pakistan.|b National Institute of Food Science and Technology , University of Agriculture Faisalabad , Pakistan.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Imran
authors.affiliation: e Department of Food Science and Human Nutrition , University of Veterinary and Animal Sciences , Lahore , Pakistan.
authors.forename: Azmat
authors.initials: A
authors.lastname: Ullah
authors.affiliation: c Institute of Home & Food Sciences , Government College University Faisalabad , Pakistan.
authors.forename: Farhan
authors.initials: F
authors.lastname: Saeed
authors.affiliation: d Department of Environmental Sciences , COMSATS Institute of Information Technology Vehari , Pakistan.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Nadeem
authors.affiliation: c Institute of Home & Food Sciences , Government College University Faisalabad , Pakistan.
authors.forename: Muhammad Umair
authors.initials: MU
authors.lastname: Arshad
authors.affiliation: f UQ School of Medicine , The University of Queensland , Australia.
authors.forename: Hafiz Ansar Rasul
authors.initials: HAR
authors.lastname: Suleria
mesh_terms: D016588:Anticarcinogenic Agents / Q000494:pharmacology; D003474:Curcumin / Q000494:pharmacology*; D006801:Humans; D009369:Neoplasms / Q000517:prevention & control*
chemical_list: D016588:Anticarcinogenic Agents; D003474:Curcumin
keywords: Turmeric; bioactive molecules; cucurmin; functional food; nutraceuticals and cancer and tumor treatment