title: Prospective Validation of Objective Prognostic Score for Advanced Cancer Inpatients in South Korea: A Multicenter Study.
abstract: Objective Prognostic Score (OPS) was developed as an easy and simple prognosticating tool in South Korea. It has been validated retrospectively in a single center in South Korea.
  
  
  
  We aimed to validate the OPS prospectively for advanced cancer inpatients in South Korea using a multicenter study.
  
  
  
  This was a prospective cohort study.
  
  
  
  We enrolled 243 advanced cancer patients admitted in five palliative care units in South Korea from May 2013 till March 2015. Seven members of the Korean Palliative Medicine Research Network who are experts of palliative care led the study.
  
  
  
  Clinical variables (dyspnea/anorexia/performance status) and laboratory variables (total leukocyte counts/serum total bilirubin/serum creatinine/lactate dehydrogenase) were collected at the enrollment. Survival time was calculated as days from enrollment to death during admission.
  
  
  
  A total of 217 patients were included in the final analysis (feasibility: 89.3%). Survival time of the higher OPS group (OPS ≥3) and the lower OPS group (OPS <3) was 10.0 (95% confidence interval (CI) 7.72-12.28) days and 32.0 (95% CI 25.44-38.56) days, respectively. There were significant differences between the 2 groups (p < 0.001). Overall accuracy of OPS ≥3 for predicting survival less than three weeks was 71.0%.
  
  
  
  OPS was successfully validated using a prospective multicenter study in South Korea. It is a useful method to predict three-week survival of Korean inpatients with advanced cancer.
authors.affiliation: 1 Department of Family Medicine, Chungnam National University Hospital , Daejeon, South Korea .
authors.forename: Seok Joon
authors.initials: SJ
authors.lastname: Yoon
authors.affiliation: 2 Department of Medicine, Dongguk University-Seoul , Seoul, South Korea .|3 Department of Family Medicine, Dongguk University Ilsan Hospital , Goyang-si, South Korea .
authors.forename: Sang-Yeon
authors.initials: SY
authors.lastname: Suh
authors.affiliation: 4 Department of Palliative Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea , Seoul, South Korea .
authors.forename: Yong Joo
authors.initials: YJ
authors.lastname: Lee
authors.affiliation: 5 Palliative Care and Hospice Center , Bobath Memorial Hospital, Sungnam, South Korea .
authors.forename: Jeanno
authors.initials: J
authors.lastname: Park
authors.affiliation: 6 Department of Family Medicine, St. Paul's Hospital, College of Medicine, The Catholic University of Korea , Seoul, South Korea .
authors.forename: Sunwook
authors.initials: S
authors.lastname: Hwang
authors.affiliation: 7 Department of Statistics, Dongguk University-Seoul , Seoul, South Korea .
authors.forename: Sanghee Shiny
authors.initials: SS
authors.lastname: Lee
authors.affiliation: 7 Department of Statistics, Dongguk University-Seoul , Seoul, South Korea .
authors.forename: Hong Yup
authors.initials: HY
authors.lastname: Ahn
authors.affiliation: 8 Department of Hemato-oncology, Ulsan University Hospital, University of Ulsan College of Medicine , Ulsan, South Korea .
authors.forename: Su-Jin
authors.initials: SJ
authors.lastname: Koh
authors.affiliation: 9 Department of Hemato-oncology, Keimyung University Dongsan Hospital , Daegu, South Korea .
authors.forename: Keon Uk
authors.initials: KU
authors.lastname: Park
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007297:Inpatients / Q000706:statistics & numerical data*; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000401:mortality* / Q000628:therapy*; D010166:Palliative Care / Q000379:methods*; D011379:Prognosis; D011446:Prospective Studies; D056910:Republic of Korea; D012189:Retrospective Studies; D016019:Survival Analysis
keywords: cancer; palliative care; prognostic score; survival; validation