title: Regenerative pharmacology: recent developments and future perspectives.
abstract: This review focuses on the current status of research that utilizes the application of pharmacological sciences to accelerate, optimize and characterize the development, maturation and function of bioengineered and regenerating tissues. These regenerative pharmacologic approaches have been applied to diseases of the urogenital tract, the heart, the brain, the musculoskeletal system and diabetes. Approaches have included the use of growth factors (such as VEGF and chemokines (stromal-derived factor - CXCL12) to mobilize cell to the sights of tissue loss or damage. The promise of this approach is to bypass the lengthy and expensive processes of cell isolation and implant fabrication to stimulate the body to heal itself with its own tissue regenerative pathways.
authors.affiliation: Wake Forest Institute for Regenerative Medicine, Wake Forest Baptist Medical Center, Winston-Salem, NC 27101, USA.
authors.forename: James Koudy
authors.initials: JK
authors.lastname: Williams
authors.affiliation: Wake Forest Institute for Regenerative Medicine, Wake Forest Baptist Medical Center, Winston-Salem, NC 27101, USA.|Institute for Clinical Medicine, Aarhus University, Aarhus, Denmark.
authors.forename: Karl-Erik
authors.initials: KE
authors.lastname: Andersson
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D006801:Humans; D010600:Pharmacology; D044968:Regenerative Medicine; D033581:Stem Cell Transplantation; D023822:Tissue Engineering / Q000379:methods*
chemical_list: D001672:Biocompatible Materials
keywords: cell mobilization; chemokines; diabetes; genitourinary regeneration; growth factors; musculoskeletal regeneration; myocardial regeneration; neurological regeneration