title: An Atypical Withdrawal Syndrome in Neonates Prenatally Exposed to Gabapentin and Opioids.
abstract: We report a retrospective case series of 19 infants exposed to both opioids and gabapentin prenatally. We describe a unique behavioral phenotype in 15 of these infants and report a treatment strategy.
authors.affiliation: Department of Pediatrics, Joan C Edwards School of Medicine at Marshall University, Huntington, WV.
authors.forename: Sean
authors.initials: S
authors.lastname: Loudin
authors.affiliation: Cabell Huntington Hospital, Huntington, WV.
authors.forename: Sara
authors.initials: S
authors.lastname: Murray
authors.affiliation: Department of Pharmacy Practice, Marshall University School of Pharmacy, Huntington, WV.
authors.forename: Leesa
authors.initials: L
authors.lastname: Prunty
authors.affiliation: Department of Clinical and Translational Science, Joan C Edwards School of Medicine of Marshall University, Huntington, WV.
authors.forename: Todd
authors.initials: T
authors.lastname: Davies
authors.affiliation: Department of Pediatrics, Joan C Edwards School of Medicine at Marshall University, Huntington, WV.
authors.forename: Joseph
authors.initials: J
authors.lastname: Evans
authors.affiliation: Department of Pediatrics, Joan C Edwards School of Medicine at Marshall University, Huntington, WV. Electronic address: werthammer@marshall.edu.
authors.forename: Joseph
authors.initials: J
authors.lastname: Werthammer
mesh_terms: D000588:Amines / Q000009:adverse effects* / Q000627:therapeutic use; D000701:Analgesics, Opioid / Q000009:adverse effects* / Q000627:therapeutic use; D003509:Cyclohexanecarboxylic Acids / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D000077206:Gabapentin; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008691:Methadone / Q000627:therapeutic use*; D009357:Neonatal Abstinence Syndrome / Q000188:drug therapy*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000453:epidemiology*; D012189:Retrospective Studies; D005680:gamma-Aminobutyric Acid / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D000588:Amines; D000701:Analgesics, Opioid; D003509:Cyclohexanecarboxylic Acids; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin; D008691:Methadone
keywords: NAS; co-exposure; gabapentin; neonatology; opioids; withdrawal