title: When biomolecules meet graphene: from molecular level interactions to material design and applications.
abstract: Graphene-based materials have attracted increasing attention due to their atomically-thick two-dimensional structures, high conductivity, excellent mechanical properties, and large specific surface areas. The combination of biomolecules with graphene-based materials offers a promising method to fabricate novel graphene-biomolecule hybrid nanomaterials with unique functions in biology, medicine, nanotechnology, and materials science. In this review, we focus on a summarization of the recent studies in functionalizing graphene-based materials using different biomolecules, such as DNA, peptides, proteins, enzymes, carbohydrates, and viruses. The different interactions between graphene and biomolecules at the molecular level are demonstrated and discussed in detail. In addition, the potential applications of the created graphene-biomolecule nanohybrids in drug delivery, cancer treatment, tissue engineering, biosensors, bioimaging, energy materials, and other nanotechnological applications are presented. This review will be helpful to know the modification of graphene with biomolecules, understand the interactions between graphene and biomolecules at the molecular level, and design functional graphene-based nanomaterials with unique properties for various applications.
authors.affiliation: State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, 100029, Beijing, China. suzq@mail.buct.edu.cn.
authors.forename: Dapeng
authors.initials: D
authors.lastname: Li
authors.affiliation: State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, 100029, Beijing, China. suzq@mail.buct.edu.cn.
authors.forename: Wensi
authors.initials: W
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, 100029, Beijing, China. suzq@mail.buct.edu.cn.
authors.forename: Xiaoqing
authors.initials: X
authors.lastname: Yu
authors.affiliation: Faculty of Production Engineering, University of Bremen, D-28359 Bremen, Germany. wei@uni-bremen.de.
authors.forename: Zhenping
authors.initials: Z
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, 100029, Beijing, China. suzq@mail.buct.edu.cn.
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Su
authors.affiliation: Faculty of Production Engineering, University of Bremen, D-28359 Bremen, Germany. wei@uni-bremen.de.
authors.forename: Gang
authors.identifier: http://orcid.org/0000-0002-3838-8659
authors.initials: G
authors.lastname: Wei