title: Does apoptotic activity have a role in the development of the placental abruption?
abstract: OBJECTIVE
  The purpose of the present study is to analyses the role of apoptotic activity in placental abruption (PA) development by evaluating the level of plasma M30-M65.
  
  
  METHODS
  The study group included 46 pregnant women who underwent caesarean sections (CS) because of PA, and the control group included 48 pregnant women who underwent CS because of obstetric causes. Venous blood samples were received from all expectants before starting the CS for the purpose of evaluating the M30-M65 levels, which are indicators of apoptotic activity in maternal plasma.
  
  
  RESULTS
  The plasma M30-M65 levels were determined to be statistically significantly higher in with PA group. The sensitivity and specificity of the test were determined to be 71.7% and 64.6%, respectively in identifying the expectants with PA when the cut-off value was taken as 163.50 U/L for the plasma M30 value. The sensitivity and specificity of the test were determined to be 76.1% and 66.7%, respectively in identifying the PA when the cut-off value was taken as 295.50 U/L for the M65 value.
  
  
  CONCLUSIONS
  The increase of apoptotic activity induced by thrombin resulting from decidual bleeding may have a role in the development of PA.
authors.affiliation: a Department of Gynecology and Obstetrics, Faculty of Medicine , Harran University , Sanliurfa , Turkey.
authors.forename: Adnan
authors.initials: A
authors.lastname: Incebiyik
authors.affiliation: a Department of Gynecology and Obstetrics, Faculty of Medicine , Harran University , Sanliurfa , Turkey.
authors.forename: Hacer
authors.identifier: http://orcid.org/0000-0003-0316-4900
authors.initials: H
authors.lastname: Uyanikoglu
authors.affiliation: a Department of Gynecology and Obstetrics, Faculty of Medicine , Harran University , Sanliurfa , Turkey.
authors.forename: Nese Gul
authors.initials: NG
authors.lastname: Hilali
authors.affiliation: a Department of Gynecology and Obstetrics, Faculty of Medicine , Harran University , Sanliurfa , Turkey.
authors.forename: Sibel
authors.initials: S
authors.lastname: Sak
authors.affiliation: a Department of Gynecology and Obstetrics, Faculty of Medicine , Harran University , Sanliurfa , Turkey.
authors.forename: Ahmet Berkiz
authors.initials: AB
authors.lastname: Turp
authors.affiliation: a Department of Gynecology and Obstetrics, Faculty of Medicine , Harran University , Sanliurfa , Turkey.
authors.forename: Muhammet Erdal
authors.initials: ME
authors.lastname: Sak
mesh_terms: D000037:Abruptio Placentae / Q000097:blood / Q000175:diagnosis / Q000209:etiology*; D000328:Adult; D017209:Apoptosis / Q000502:physiology*; D051017:Apoptosis Regulatory Proteins / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D053538:Keratin-18 / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D011237:Predictive Value of Tests; D011247:Pregnancy; D012680:Sensitivity and Specificity
chemical_list: D051017:Apoptosis Regulatory Proteins; D015415:Biomarkers; D053538:Keratin-18; C561463:M30 cytokeratin-18 peptide, human; C577325:M65 antigen, human; D010446:Peptide Fragments
keywords: M30; M65; Placental abruption; apoptosis; thrombin