title: [Antifungal medication: new substances, new experiences].
abstract: The incidence of life threatening invasive fungal infections in patients with hematological malignancies during intensive chemotherapy or after hematopoetic stem cell transplantation, patients after solid organ transplantation, ICU patients and premature infants is rising. Mortality rates of invasive fungal infections, caused byAspergillusspecies or mucormycetes, may reach 100%, in spite of considerable progress in diagnosis, antifungal prophylaxis and therapy. Comprehensive, profound knowledge of specific diagnostic and current treatment algorithms is essential to improve the prognosis of patients suffering from systemic fungal infections; this article encompasses recent developments in the field of antifungal treatment.
authors.forename: Dieter
authors.initials: D
authors.lastname: Buchheidt
authors.forename: Wolf-Karsten
authors.initials: WK
authors.lastname: Hofmann
mesh_terms: D000935:Antifungal Agents / Q000008:administration & dosage* / Q000145:classification*; D019317:Evidence-Based Medicine; D006801:Humans; D009172:Mycology / Q000379:methods* / Q000639:trends*; D009181:Mycoses / Q000145:classification / Q000175:diagnosis* / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents