title: [Liver metastases of malignant melanoma - utility of resection or radiofrequency ablation].
abstract: BACKGROUND
  Incidence of cutaneous and uveal forms of malignant melanoma (MM) has increased significantly in the population in the last years. Biological behavior of both these forms of MM is different and is associated with the development of liver metastases. The prognosis of patients with MM liver metastases is generally poor. The authors seek to consider the sense and the possibilities of surgical treatment of MM liver metastases.
  
  
  METHODS
  Seven patients with liver metastases of MM were operated on in the Hepatobiliary Center of the Department of Surgery, University Hospital in Pilsen during the last ten years. Four patients suffered from the uveal and three from the cutaneous form of MM. Mean age of the patients was 58.8 years. R0 liver resection was performed in 3, and radiofrequency ablation in 1 patient. In the remaining 3 patients the operation finished by exploratory laparotomy due to tumor progression.
  
  
  RESULTS
  Two patients died in the interval of 6 and 25 months after liver surgery for tumor dissemination. Two patients continue to show disease free survival, currently of 22 and 28 months.
  
  
  CONCLUSIONS
  Liver metastases of MM have a very poor prognosis. Surgical treatment indicated by the multidisciplinary team provides, together with further multimodal treatment, a chance for long-term survival and its indication is justified in selected patients.Key words: malignant melanoma - liver metastases - surgical treatment.
authors.forename: V
authors.initials: V
authors.lastname: Třeška
authors.forename: T
authors.initials: T
authors.lastname: Skalický
authors.forename: I
authors.initials: I
authors.lastname: Třešková
authors.forename: V
authors.initials: V
authors.lastname: Liška
authors.forename: J
authors.initials: J
authors.lastname: Fichtl
authors.forename: J
authors.initials: J
authors.lastname: Brůha
authors.forename: E
authors.initials: E
authors.lastname: Korčáková
mesh_terms: D017115:Catheter Ablation; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D006498:Hepatectomy; D006785:Hospitals, University; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary / Q000601:surgery*; D008545:Melanoma / Q000556:secondary / Q000601:surgery*; D059146:Metastasectomy; D011379:Prognosis; D012878:Skin Neoplasms / Q000473:pathology*