title: Rationale for the Successful Management of EDTA Chelation Therapy in Human Burden by Toxic Metals.
abstract: Exposure to environmental and occupational toxicants is responsible for adverse effects on human health. Chelation therapy is the only procedure able to remove toxic metals from human organs and tissue, aiming to treat damage related to acute and/or chronic intoxication. The present review focuses on the most recent evidence of the successful use of the chelating agent ethylenediaminetetraacetic acid (EDTA). Assessment of toxic-metal presence in humans, as well as the rationale of EDTA therapy in cardiovascular and neurodegenerative diseases, is reported.
authors.affiliation: Dipartimento di Scienze Biomediche per la Salute, Università degli Studi di Milano, Via Mangiagalli 31, Milan, Italy.
authors.forename: Maria Elena
authors.identifier: 0000-0001-8969-7980
authors.initials: ME
authors.lastname: Ferrero
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry; D002614:Chelating Agents / Q000737:chemistry*; D004492:Edetic Acid / Q000737:chemistry*; D004785:Environmental Pollutants / Q000737:chemistry; D005260:Female; D005843:Geography; D006801:Humans; D007249:Inflammation; D007501:Iron / Q000737:chemistry; D008297:Male; D008670:Metals / Q000737:chemistry*; D008875:Middle Aged; D019636:Neurodegenerative Diseases / Q000209:etiology; D016273:Occupational Exposure; D011247:Pregnancy; D011248:Pregnancy Complications; D051381:Rats; D017208:Rats, Wistar; D013789:Thalassemia / Q000097:blood
chemical_list: D000975:Antioxidants; D002614:Chelating Agents; D004785:Environmental Pollutants; D008670:Metals; D004492:Edetic Acid; D007501:Iron