title: Complete response with sorafenib and transcatheter arterial chemoembolization in unresectable hepatocellular carcinoma.
abstract: Patients with advanced hepatocellular carcinoma (HCC) showing portal vein tumor thrombosis (PVTT) have an extremely poor prognosis. According to treatment guidelines, the only option for HCC patients with PVTT is sorafenib chemotherapy. However, in Asia, various treatments have been attempted and possible prolongation of overall survival has been repeatedly reported. We herein report the first case of a patient with an initially unresectable advanced HCC with PVTT who underwent curative hepatectomy after sorafenib and transcatheter arterial chemoembolization (TACE) showing complete histological response. Two months after induction with sorafenib, a significant decrease in serum alpha-fetoprotein level was observed and computed tomography imaging showed a significant decrease in tumor size. Because of remaining PVTT, TACE and curative resection were performed. The combination of sorafenib and TACE may be an effective treatment for HCC patients with PVTT.
authors.affiliation: Michitoshi Takano, Takashi Kokudo, Yoshihiro Miyazaki, Yumiko Kageyama, Amane Takahashi, Katsumi Amikura, Hirohiko Sakamoto, Division of gastroenterological surgery, Saitama Cancer Center, Kitaadachi-gun, Saitama 362-0806, Japan.
authors.forename: Michitoshi
authors.initials: M
authors.lastname: Takano
authors.affiliation: Michitoshi Takano, Takashi Kokudo, Yoshihiro Miyazaki, Yumiko Kageyama, Amane Takahashi, Katsumi Amikura, Hirohiko Sakamoto, Division of gastroenterological surgery, Saitama Cancer Center, Kitaadachi-gun, Saitama 362-0806, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Kokudo
authors.affiliation: Michitoshi Takano, Takashi Kokudo, Yoshihiro Miyazaki, Yumiko Kageyama, Amane Takahashi, Katsumi Amikura, Hirohiko Sakamoto, Division of gastroenterological surgery, Saitama Cancer Center, Kitaadachi-gun, Saitama 362-0806, Japan.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Miyazaki
authors.affiliation: Michitoshi Takano, Takashi Kokudo, Yoshihiro Miyazaki, Yumiko Kageyama, Amane Takahashi, Katsumi Amikura, Hirohiko Sakamoto, Division of gastroenterological surgery, Saitama Cancer Center, Kitaadachi-gun, Saitama 362-0806, Japan.
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Kageyama
authors.affiliation: Michitoshi Takano, Takashi Kokudo, Yoshihiro Miyazaki, Yumiko Kageyama, Amane Takahashi, Katsumi Amikura, Hirohiko Sakamoto, Division of gastroenterological surgery, Saitama Cancer Center, Kitaadachi-gun, Saitama 362-0806, Japan.
authors.forename: Amane
authors.initials: A
authors.lastname: Takahashi
authors.affiliation: Michitoshi Takano, Takashi Kokudo, Yoshihiro Miyazaki, Yumiko Kageyama, Amane Takahashi, Katsumi Amikura, Hirohiko Sakamoto, Division of gastroenterological surgery, Saitama Cancer Center, Kitaadachi-gun, Saitama 362-0806, Japan.
authors.forename: Katsumi
authors.initials: K
authors.lastname: Amikura
authors.affiliation: Michitoshi Takano, Takashi Kokudo, Yoshihiro Miyazaki, Yumiko Kageyama, Amane Takahashi, Katsumi Amikura, Hirohiko Sakamoto, Division of gastroenterological surgery, Saitama Cancer Center, Kitaadachi-gun, Saitama 362-0806, Japan.
authors.forename: Hirohiko
authors.initials: H
authors.lastname: Sakamoto
mesh_terms: D000368:Aged; D015901:Angiography, Digital Subtraction; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D006528:Carcinoma, Hepatocellular / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D016461:Chemoembolization, Therapeutic; D006498:Hepatectomy; D006801:Humans; D008113:Liver Neoplasms / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D008297:Male; D009536:Niacinamide / Q000031:analogs & derivatives* / Q000627:therapeutic use; D010671:Phenylurea Compounds / Q000627:therapeutic use*; D010690:Phlebography / Q000379:methods; D011169:Portal Vein / Q000000981:diagnostic imaging; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use*; D000077157:Sorafenib; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D020246:Venous Thrombosis / Q000000981:diagnostic imaging / Q000209:etiology / Q000628:therapy
chemical_list: D000970:Antineoplastic Agents; D010671:Phenylurea Compounds; D047428:Protein Kinase Inhibitors; D009536:Niacinamide; D000077157:Sorafenib
keywords: Complete response; Hepatocellular carcinoma; Portal vein tumor thrombosis; Sorafenib; Transcatheter arterial chemoembolization