title: Targeting SPOP with small molecules provides a novel strategy for kidney cancer therapy.
authors.affiliation: Laboratory of Chemical Biology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.|University of Chinese Academy of Sciences, Beijing, 100049, China.
authors.forename: Tong
authors.initials: T
authors.lastname: Zheng
authors.affiliation: Laboratory of Chemical Biology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. yangcg@simm.ac.cn.
authors.forename: Cai-Guang
authors.initials: CG
authors.lastname: Yang
mesh_terms: D002292:Carcinoma, Renal Cell / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D006801:Humans; D007680:Kidney Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D008954:Models, Biological; D015394:Molecular Structure; D058990:Molecular Targeted Therapy; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism*; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects*; D054852:Small Molecule Libraries / Q000737:chemistry / Q000627:therapeutic use*
chemical_list: D009687:Nuclear Proteins; D012097:Repressor Proteins; C509761:SPOP protein, human; D054852:Small Molecule Libraries