title: Improved Glucose Homeostasis in Obese Mice Treated With Resveratrol Is Associated With Alterations in the Gut Microbiome.
abstract: Oral administration of resveratrol is able to improve glucose homeostasis in obese individuals. Herein we show that resveratrol ingestion produces taxonomic and predicted functional changes in the gut microbiome of obese mice. In particular, changes in the gut microbiome were characterized by a decreased relative abundance of Turicibacteraceae, Moryella, Lachnospiraceae, and Akkermansia and an increased relative abundance of Bacteroides and Parabacteroides Moreover, fecal transplantation from healthy resveratrol-fed donor mice is sufficient to improve glucose homeostasis in obese mice, suggesting that the resveratrol-mediated changes in the gut microbiome may play an important role in the mechanism of action of resveratrol.
authors.affiliation: Cardiovascular Research Centre, Department of Pediatrics, and the Alberta Diabetes Institute, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, Alberta, Canada.
authors.forename: Miranda M
authors.initials: MM
authors.lastname: Sung
authors.affiliation: Cardiovascular Research Centre, Department of Pediatrics, and the Alberta Diabetes Institute, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, Alberta, Canada.
authors.forename: Ty T
authors.initials: TT
authors.lastname: Kim
authors.affiliation: Department of Biochemistry and Biomedical Sciences and Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Denou
authors.affiliation: Cardiovascular Research Centre, Department of Pediatrics, and the Alberta Diabetes Institute, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, Alberta, Canada.
authors.forename: Carrie-Lynn M
authors.initials: CM
authors.lastname: Soltys
authors.affiliation: Cardiovascular Research Centre, Department of Pediatrics, and the Alberta Diabetes Institute, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, Alberta, Canada.
authors.forename: Shereen M
authors.initials: SM
authors.lastname: Hamza
authors.affiliation: Cardiovascular Research Centre, Department of Pediatrics, and the Alberta Diabetes Institute, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, Alberta, Canada.
authors.forename: Nikole J
authors.initials: NJ
authors.lastname: Byrne
authors.affiliation: Cardiovascular Research Centre, Department of Pediatrics, and the Alberta Diabetes Institute, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, Alberta, Canada.
authors.forename: Grant
authors.initials: G
authors.lastname: Masson
authors.affiliation: Division of Gastroenterology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.
authors.forename: Heekuk
authors.initials: H
authors.lastname: Park
authors.affiliation: The Metabolomics Innovation Centre, University of Alberta, Edmonton, Alberta, Canada.
authors.forename: David S
authors.initials: DS
authors.lastname: Wishart
authors.affiliation: Division of Gastroenterology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.
authors.forename: Karen L
authors.initials: KL
authors.lastname: Madsen
authors.affiliation: Department of Biochemistry and Biomedical Sciences and Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada.
authors.forename: Jonathan D
authors.initials: JD
authors.lastname: Schertzer
authors.affiliation: Cardiovascular Research Centre, Department of Pediatrics, and the Alberta Diabetes Institute, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, Alberta, Canada jason.dyck@ualberta.ca.
authors.forename: Jason R B
authors.initials: JR
authors.lastname: Dyck
mesh_terms: D000818:Animals; D001439:Bacteroides; D001786:Blood Glucose / Q000187:drug effects* / Q000378:metabolism; D002853:Chromatography, Liquid; D000069467:Fecal Microbiota Transplantation; D000069196:Gastrointestinal Microbiome / Q000187:drug effects* / Q000235:genetics; D005947:Glucose / Q000378:metabolism; D005951:Glucose Tolerance Test; D006706:Homeostasis / Q000187:drug effects; D008297:Male; D051379:Mice; D008820:Mice, Obese; D009765:Obesity / Q000378:metabolism* / Q000382:microbiology; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology*; D053719:Tandem Mass Spectrometry
chemical_list: D001786:Blood Glucose; D013267:Stilbenes; D005947:Glucose; D000077185:Resveratrol