title: Diabetic Macular Ischemia Diagnosis: Comparison between Optical Coherence Tomography Angiography and Fluorescein Angiography.
abstract: Purpose. To compare fluorescein angiography (FA) and optical coherence tomography angiography (OCTA) images of foveal avascular zone (FAZ) in patients with diabetic retinopathy (DR) with and without diabetic macular ischemia (DMI).Methods. The Wilcoxon signed-rank test was used to compare area measurements andpvalues of <0.05 were considered statistically significant. FA and OCTA images were independently graded by 2 observers that reached agreement regarding quantitative DMI according established protocols. The ischemic area was divided into "large" macular ischemia (superior to 0.32 mm2) and "small" (inferior to 0.32 mm2) groups. Quantitative analyses of the FAZ were performed using custom software.Results. Thirty-four eyes from 34 diabetic patients were enrolled. Subjects with DMI presented a mean area on FA and OCTA of 0.68 ± 0.53 mm2and 0.58 ± 0.35 mm2, respectively (p= 0.1374). Patients without DMI presented a mean area on FA and OCTA of 0.19 ± 0.67 mm2and 0.20 ± 0.79 mm2, respectively (p= 0.9594). The ICC for the FAZ measurements between the 2 observers on FA and OCTA was 0.96 and 0.92, respectively.Conclusion. OCTA represents a novel technique for the diagnosis of DMI and it may become an alternative to FA for this purpose.
authors.affiliation: Federal University of Goias, Av. Primeira Avenida, S/N, Setor Leste Universitario, 74605-020 Goiania, GO, Brazil.
authors.forename: Jose Mauricio Botto de Barros
authors.identifier: 0000-0002-9799-5360
authors.initials: JM
authors.lastname: Garcia
authors.affiliation: Federal University of Goias, Av. Primeira Avenida, S/N, Setor Leste Universitario, 74605-020 Goiania, GO, Brazil.
authors.forename: Talita Toledo
authors.initials: TT
authors.lastname: Lima
authors.affiliation: Federal University of Goias, Av. Primeira Avenida, S/N, Setor Leste Universitario, 74605-020 Goiania, GO, Brazil.
authors.forename: Ricardo Noguera
authors.initials: RN
authors.lastname: Louzada
authors.affiliation: Federal University of Goias, Av. Primeira Avenida, S/N, Setor Leste Universitario, 74605-020 Goiania, GO, Brazil.
authors.forename: Alessandra Thome
authors.initials: AT
authors.lastname: Rassi
authors.affiliation: Federal University of Goias, Av. Primeira Avenida, S/N, Setor Leste Universitario, 74605-020 Goiania, GO, Brazil.
authors.forename: David Leonardo Cruvinel
authors.initials: DL
authors.lastname: Isaac
authors.affiliation: Federal University of Goias, Av. Primeira Avenida, S/N, Setor Leste Universitario, 74605-020 Goiania, GO, Brazil.
authors.forename: Marcos
authors.initials: M
authors.lastname: Avila