title: Structural and Functional Connectivity of Default Mode Network underlying the Cognitive Impairment in Late-onset Depression.
abstract: To identify the association between the functional and structural changes of default mode network (DMN) underlying the cognitive impairment in Late-onset depression (LOD), 32 LOD patients and 39 normal controls were recruited and underwent resting-state fMRI, DTI scans, and cognitive assessments. Seed-based correlation analysis was conducted to explore the functional connectivity (FC) of the DMN. Deterministic tractography between FC-impaired regions was performed to examine the structural connectivity (SC). Partial correlation analyses were employed to evaluate the cognitive association of those altered FC and SC. Compared with controls, LOD patients showed decreased FC between DMN and the cingulo-opercular network (CON), as well as the thalamus. Decreased FA and increased RD of these fiber tracts connecting DMN with CON were found in LOD patient. The DMN-CON FC and the FA, RD of the fiber tracts were both significantly correlated with the cognitive performance. Therefore, the cognitive impairment in LOD might be associated with the decreased FC between the DMN and the CON, which probably resulted from the demyelination of the white matter.
authors.affiliation: Department of Psychosomatics and Psychiatry, ZhongDa Hospital, School of Medicine, Southeast University, Nanjing 210009, P. R. China.|Institute of Psychosomatics, Medical School of Southeast University, Nanjing 210009, China.
authors.forename: Yingying
authors.initials: Y
authors.lastname: Yin
authors.affiliation: Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York 10032, USA.
authors.forename: Xiaofu
authors.initials: X
authors.lastname: He
authors.affiliation: Department of Biomedical Engineering, Peking University, Beijing 100871, China.
authors.forename: Mingze
authors.initials: M
authors.lastname: Xu
authors.affiliation: Department of Psychosomatics and Psychiatry, ZhongDa Hospital, School of Medicine, Southeast University, Nanjing 210009, P. R. China.|Institute of Psychosomatics, Medical School of Southeast University, Nanjing 210009, China.
authors.forename: Zhenghua
authors.initials: Z
authors.lastname: Hou
authors.affiliation: Department of Biomedical Engineering, Peking University, Beijing 100871, China.
authors.forename: Xiaopeng
authors.initials: X
authors.lastname: Song
authors.affiliation: Department of Psychiatry, Nanjing Medical University affiliated Nanjing Brain Hospital, Nanjing, China.
authors.forename: Yuxiu
authors.initials: Y
authors.lastname: Sui
authors.affiliation: Shandong Provincial Key Laboratory of Wireless Communication Technologies, School of Information Science and Engineering, Shandong University, Jinan 250100, China.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Department of Psychosomatics and Psychiatry, ZhongDa Hospital, School of Medicine, Southeast University, Nanjing 210009, P. R. China.|Institute of Psychosomatics, Medical School of Southeast University, Nanjing 210009, China.
authors.forename: Wenhao
authors.initials: W
authors.lastname: Jiang
authors.affiliation: Department of Psychosomatics and Psychiatry, ZhongDa Hospital, School of Medicine, Southeast University, Nanjing 210009, P. R. China.|Institute of Psychosomatics, Medical School of Southeast University, Nanjing 210009, China.
authors.forename: Yingying
authors.initials: Y
authors.lastname: Yue
authors.affiliation: Department of Psychosomatics and Psychiatry, ZhongDa Hospital, School of Medicine, Southeast University, Nanjing 210009, P. R. China.|Institute of Psychosomatics, Medical School of Southeast University, Nanjing 210009, China.
authors.forename: Yuqun
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Psychiatry &McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA.|Department of Psychology, Southwest University, Chongqing 400715, China.
authors.forename: Yijun
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Psychosomatics and Psychiatry, ZhongDa Hospital, School of Medicine, Southeast University, Nanjing 210009, P. R. China.|Institute of Psychosomatics, Medical School of Southeast University, Nanjing 210009, China.
authors.forename: Yonggui
authors.initials: Y
authors.lastname: Yuan
mesh_terms: D000368:Aged; D001921:Brain / Q000503:physiopathology; D001931:Brain Mapping; D060825:Cognitive Dysfunction / Q000503:physiopathology*; D003710:Demography; D003863:Depression / Q000503:physiopathology*; D056324:Diffusion Tensor Imaging; D005260:Female; D006801:Humans; D008297:Male; D009415:Nerve Net / Q000503:physiopathology*; D009483:Neuropsychological Tests