title: Adult Patients With Bronchiectasis: A First Look at the US Bronchiectasis Research Registry.
abstract: We sought to describe the characteristics of adult patients with bronchiectasis enrolled in the US Bronchiectasis Research Registry (BRR).
  
  
  
  The BRR is a database of patients with non-cystic-fibrosis bronchiectasis (NCFB) enrolled at 13 sites in the United States. Baseline demographic, spirometric, imaging, microbiological, and therapeutic data were entered into a central Internet-based database. Patients were subsequently analyzed by the presence of NTM.
  
  
  
  We enrolled 1,826 patients between 2008 and 2014. Patients were predominantly women (79%), white (89%), and never smokers (60%), with a mean age of 64 ± 14 years. Sixty-three percent of the patients had a history of NTM disease or NTM isolated at baseline evaluation for entry into the BRR. Patients with NTM were older, predominantly women, and had bronchiectasis diagnosed at a later age than those without NTM. Gastroesophageal reflux disease (GERD) was more common in those with NTM, whereas asthma, primary immunodeficiency, and primary ciliary dyskinesia were more common in those without NTM. Fifty-one percent of patients had spirometric evidence of airflow obstruction. Patients with NTM were more likely to have diffusely dilated airways and tree-in-bud abnormalities. Pseudomonas and Staphylococcus aureus isolates were cultured less commonly in patients with NTM. Bronchial hygiene measures were used more often in those with NTM, whereas antibiotics used for exacerbations, rotating oral antibiotics, steroid use, and inhaled bronchodilators were more commonly used in those without NTM.
  
  
  
  Adult patients with bronchiectasis enrolled in the US BRR are described, with differences noted in demographic, radiographic, microbiological, and treatment variables based on stratification of the presence of NTM.
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN. Electronic address: aksamit.timothy@mayo.edu.
authors.forename: Timothy R
authors.initials: TR
authors.lastname: Aksamit
authors.affiliation: Division of Pulmonary, Critical Care, and Sleep Medicine, Georgetown University Hospital, Washington, DC.
authors.forename: Anne E
authors.initials: AE
authors.lastname: O'Donnell
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Department of Medicine, Oregon Health & Science University, Portland, OR.
authors.forename: Alan
authors.initials: A
authors.lastname: Barker
authors.affiliation: Cardiovascular and Pulmonary Branch, National Institute of Allergy and Infectious Diseases, Bethesda, MD.
authors.forename: Kenneth N
authors.initials: KN
authors.lastname: Olivier
authors.affiliation: Division of Infectious Disease, Department of Public Health and Preventive Medicine, Oregon Health & Science University, Portland, OR.
authors.forename: Kevin L
authors.initials: KL
authors.lastname: Winthrop
authors.affiliation: Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC.
authors.forename: M Leigh Anne
authors.initials: MLA
authors.lastname: Daniels
authors.affiliation: Division of Pulmonary and Critical Care, Mayo Clinic Florida, Jacksonville, FL.
authors.forename: Margaret
authors.initials: M
authors.lastname: Johnson
authors.affiliation: Department of Pulmonary, Critical Care, and Sleep Medicine, St. Luke's-Roosevelt Hospital Center at Columbia University, New York, NY.
authors.forename: Edward
authors.initials: E
authors.lastname: Eden
authors.affiliation: Pulmonary Infectious Disease Section, University of Texas Health Science Center, Tyler, TX.
authors.forename: David
authors.initials: D
authors.lastname: Griffith
authors.affiliation: Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC.
authors.forename: Michael
authors.initials: M
authors.lastname: Knowles
authors.affiliation: Division of Pulmonary and Critical Care Medicine, University of Connecticut School of Medicine, Farmington, CT.
authors.forename: Mark
authors.initials: M
authors.lastname: Metersky
authors.affiliation: Miller School of Medicine, University of Miami, Miami, FL.
authors.forename: Matthias
authors.initials: M
authors.lastname: Salathe
authors.affiliation: Center for Chest Disease, Columbia University Medical Center-NY Presbyterian Hospital, New York, NY.
authors.forename: Byron
authors.initials: B
authors.lastname: Thomashow
authors.affiliation: Department of Medicine, Penn Presbyterian Medical Center, Philadelphia, PA; University of Pennsylvania School of Medicine, Philadelphia, PA.
authors.forename: Gregory
authors.initials: G
authors.lastname: Tino
authors.affiliation: Department of Medicine, St. Luke's-Roosevelt Hospital Center at Columbia University, New York, NY.
authors.forename: Gerard
authors.initials: G
authors.lastname: Turino
authors.affiliation: Collaborative Studies Coordinating Center, University of North Carolina at Chapel Hill, Chapel Hill, NC.
authors.forename: Betsy
authors.initials: B
authors.lastname: Carretta
authors.affiliation: Division of Mycobacterial and Respiratory Infections, National Jewish Health, Denver, CO.
authors.forename: Charles L
authors.initials: CL
authors.lastname: Daley
mesh_terms: D000328:Adult; D001741:Black or African American / Q000706:statistics & numerical data; D000368:Aged; D000818:Animals; D001249:Asthma / Q000453:epidemiology; D035843:Biomedical Research; D001987:Bronchiectasis / Q000453:epidemiology* / Q000382:microbiology / Q000503:physiopathology; D015897:Comorbidity; D005006:Ethnicity / Q000706:statistics & numerical data; D005260:Female; D005541:Forced Expiratory Volume; D005764:Gastroesophageal Reflux / Q000453:epidemiology; D006630:Hispanic or Latino / Q000706:statistics & numerical data; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000453:epidemiology*; D007348:Insurance, Health; D007619:Kartagener Syndrome / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D009165:Mycobacterium Infections, Nontuberculous / Q000453:epidemiology* / Q000382:microbiology; D009170:Nontuberculous Mycobacteria; D010031:Otitis / Q000453:epidemiology; D011549:Pseudomonas; D011552:Pseudomonas Infections / Q000453:epidemiology; D012042:Registries; D012220:Rhinitis / Q000453:epidemiology; D012852:Sinusitis / Q000453:epidemiology; D012907:Smoking / Q000453:epidemiology; D013147:Spirometry; D013203:Staphylococcal Infections / Q000453:epidemiology; D013211:Staphylococcus aureus; D014057:Tomography, X-Ray Computed; D014481:United States / Q000453:epidemiology; D014797:Vital Capacity; D044465:White People / Q000706:statistics & numerical data
keywords: Pseudomonas; airways; bronchiectasis; nontuberculous mycobacteria; registry