title: Intense Uptake in Amyloidosis of the Seminal Vesicles on 68Ga-PSMA PET Mimicking Locally Advanced Prostate Cancer.
abstract: We report a case of benign senile seminal vesicle amyloidosis demonstrating intense Ga-prostate-specific membrane antigen (PSMA) uptake on PET/CT. A 68-year-old man underwent staging PSMA PET/CT and MRI for biopsy-proven prostate adenocarcinoma. There was an intense focus of Ga-PSMA uptake in the primary malignancy, as well as symmetrical intense uptake in the seminal vesicles bilaterally that was reported as multifocal disease with local invasion. Final histology after radical prostatectomy showed amyloidosis of the seminal vesicles without any evidence of prostate cancer. Care should be taken in the interpretation of seminal vesicle PSMA uptake to avoid overstaging.
authors.affiliation: From the *Department of Nuclear Medicine, Royal Brisbane and Women's Hospital, Herston, Queensland; †School of Medicine, University of Queensland, Brisbane, Queensland; ‡Royal Brisbane and Women's Hospital, Herston; §Department of Anatomical Pathology, Pathology Queensland, Princess Alexandra Hospital, Woolloongabba, Queensland; ∥Department of Medical Imaging, Royal Brisbane and Women's Hospital, Herston, Queensland; and ¶Herston Imaging Research Facility, Brisbane, Queensland, Australia.
authors.forename: Maximilian
authors.initials: M
authors.lastname: Stephens
authors.forename: David Insoo
authors.initials: DI
authors.lastname: Kim
authors.forename: Benjamin
authors.initials: B
authors.lastname: Shepherd
authors.forename: Sonja
authors.initials: S
authors.lastname: Gustafson
authors.forename: Paul
authors.initials: P
authors.lastname: Thomas
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging*; D000368:Aged; D000686:Amyloidosis / Q000000981:diagnostic imaging*; D003937:Diagnosis, Differential; D004492:Edetic Acid / Q000031:analogs & derivatives; D005709:Gallium Isotopes; D005710:Gallium Radioisotopes; D006801:Humans; D008297:Male; D009842:Oligopeptides; D009942:Organometallic Compounds; D049268:Positron-Emission Tomography; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging*; D019275:Radiopharmaceuticals; D012669:Seminal Vesicles / Q000000981:diagnostic imaging*
chemical_list: D005709:Gallium Isotopes; D005710:Gallium Radioisotopes; D009842:Oligopeptides; D009942:Organometallic Compounds; D019275:Radiopharmaceuticals; C000718244:gallium 68 PSMA-11; D004492:Edetic Acid