title: Initial clinical experience with the Medtronic Micro Vascular Plug™ in transcatheter occlusion of PDAs in extremely premature infants.
abstract: OBJECTIVE
  To describe the early multicenter, clinical experience with the Medtronic Micro Vascular Plug™ (MVP) for the occlusion of patent ductus arteriosus (PDA) in premature infants.
  
  
  BACKGROUND
  The MVP is a large diameter plug that can be delivered through a microcatheter for occlusion of abnormal blood vessels.
  
  
  METHODS
  A Retrospective review of PDA embolization procedures performed in two centers using the MVP was performed.
  
  
  RESULTS
  Fifteen premature infants underwent attempted PDA occlusion using the MVP. The gestational age and birth weight were 25.6 ± 2.5 weeks and 735 ± 251 g, respectively. The median weight and age at the time of the procedure were 1,210 g (700-3,500 g) and 4.5 weeks (2-12 weeks), respectively. Median procedure and fluoroscopy times were 45 and 6.5 min, respectively. The median radiation and contrast doses were 19.7 mGy and 2.4 mL/kg, respectively. Antegrade occlusion was successfully achieved in 13 patients <2 kg with only femoral venous access aided by echo guidance. The two patients >2 kg had arterial access and attempted retrograde occlusion; one of which was unsuccessful due to the PDA being short and wide. Complete closure was observed in 13 of 14 successful procedures (93%), with one patient having a small residual shunt that was not seen on follow-up. There were no complications related to the procedure or noted during follow-up (Median 11 months).
  
  
  CONCLUSIONS
  The MVP is a new, large-diameter vascular embolization device that may be useful for the occlusion of PDA in extremely small, premature infants. © 2016 Wiley Periodicals, Inc.
authors.affiliation: Division of Pediatric Cardiology, Department of Pediatrics, University of Tennessee Health Science Center, LeBonheur Children's Hospital, Memphis, Tennessee.
authors.forename: Shyam
authors.initials: S
authors.lastname: Sathanandam
authors.affiliation: Division of Pediatric Cardiology, Department of Pediatrics, The Lillie Frank Abercrombie Section of Cardiology, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas.
authors.forename: Henri
authors.initials: H
authors.lastname: Justino
authors.affiliation: Division of Pediatric Cardiology, Department of Pediatrics, University of Tennessee Health Science Center, LeBonheur Children's Hospital, Memphis, Tennessee.
authors.forename: B Rush
authors.initials: BR
authors.lastname: Waller
authors.affiliation: Division of Pediatric Cardiology, Department of Pediatrics, A.I. Dupont Hospital For Children, Wilmington, Delaware.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Radtke
authors.affiliation: Division of Pediatric Cardiology, Department of Pediatrics, The Lillie Frank Abercrombie Section of Cardiology, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas.
authors.forename: Athar M
authors.initials: AM
authors.lastname: Qureshi
mesh_terms: D001027:Aortography; D001724:Birth Weight; D006328:Cardiac Catheterization / Q000009:adverse effects / Q000295:instrumentation*; D004374:Ductus Arteriosus, Patent / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy*; D018618:Echocardiography, Doppler, Color; D005260:Female; D005865:Gestational Age; D006801:Humans; D062071:Infant, Extremely Premature; D007231:Infant, Newborn; D008297:Male; D011474:Prosthesis Design; D012189:Retrospective Studies; D055989:Septal Occluder Device; D013714:Tennessee; D013781:Texas; D013997:Time Factors; D016896:Treatment Outcome
keywords: Micro Vascular Plug™; patent ductus arteriosus; premature