title: Cortactin promotes colorectal cancer cell proliferation by activating the EGFR-MAPK pathway.
abstract: Cortactin (CTTN) is overexpressed in various tumors, including head and neck squamous cell carcinoma and colorectal cancer (CRC), and can serve as a biomarker of cancer metastasis. We observed that CTTN promotes cancer cell proliferation in vitro and increases CRC tumor xenograft growth in vivo. CTTN expression increases EGFR protein levels and enhances the activation of the MAPK signaling pathway. CTTN expression also inhibits the ubiquitin-mediated degradation of EGFR by suppressing the coupling of c-Cbl with EGFR. CoIP experiments indicate CTTN can interact with c-Cbl in CRC cells. These results demonstrate that CTTN promotes the proliferation of CRC cells and suppresses the degradation of EGFR.
authors.affiliation: Department of Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.|Shanghai Institute of Digestive Surgery, Shanghai, People's Republic of China.
authors.forename: Xiaojian
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Surgery, Ruijin Hospital North, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
authors.forename: Kun
authors.initials: K
authors.lastname: Liu
authors.affiliation: Department of Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
authors.forename: Tao
authors.initials: T
authors.lastname: Zhang
authors.affiliation: Department of Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.|Department of Surgery, Henan Cancer Hospital, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, Henan Province, People's Republic of China.
authors.forename: Zhenlei
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.|Shanghai Institute of Digestive Surgery, Shanghai, People's Republic of China.
authors.forename: Xuan
authors.initials: X
authors.lastname: Qin
authors.affiliation: Department of Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.|Shanghai Institute of Digestive Surgery, Shanghai, People's Republic of China.
authors.forename: Xiaoqian
authors.initials: X
authors.lastname: Jing
authors.affiliation: Department of Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.|Shanghai Institute of Digestive Surgery, Shanghai, People's Republic of China.
authors.forename: Haoxuan
authors.initials: H
authors.lastname: Wu
authors.affiliation: Department of Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
authors.forename: Xiaopin
authors.initials: X
authors.lastname: Ji
authors.affiliation: Department of Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
authors.forename: Yonggang
authors.initials: Y
authors.lastname: He
authors.affiliation: Department of Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
authors.forename: Ren
authors.initials: R
authors.lastname: Zhao
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000502:physiology; D015179:Colorectal Neoplasms / Q000201:enzymology* / Q000473:pathology; D051356:Cortactin / Q000378:metabolism*; D066246:ErbB Receptors / Q000378:metabolism*; D045325:HCT116 Cells; D019073:HT29 Cells; D064593:Heterografts; D006801:Humans; D020935:MAP Kinase Signaling System; D008297:Male; D051379:Mice
chemical_list: C495868:CTTN protein, human; D051356:Cortactin; C512478:EGFR protein, human; D066246:ErbB Receptors
keywords: MAPK; c-Cbl; colorectal cancer; cortactin(CTTN); epidermal growth factor receptor (EGFR)