title: Association of Performance Status and Pain in Metastatic Bone Pain Management in the Spanish Clinical Setting.
abstract: Bone metastasis is the most common cause of cancer-related pain, and metastatic bone pain (MBP) is not only severe but also progressive in many patients. The aim of this study was to investigate the association between pain management and performance status in patients with metastatic bone cancer in the Spanish clinical setting.
  
  
  
  A 3-month follow-up prospective, epidemiologic, multicenter study was conducted in 579 patients to assess the evolution of their performance, the impact of pain control on sleep and functionality, and the degree of pain control according to analgesic treatment.
  
  
  
  In patients with MBP, Eastern Cooperative Oncology Group (ECOG) status (1.5 ± 0.7-1.3 ± 0.7 and 1.3 ± 0.8; p < 0.001) and pain (6.5 ± 1.4-2.8 ± 1.9 and 2.1 ± 1.9; p < 0.001) improved significantly from baseline to months 1 and 3, as did functionality and sleep, after a treatment change consisting of increasing the administration of opioids. Evolution of ECOG and pain were closely related. ECOG and pain outcomes were significantly more favorable in patients treated with opioids versus non-opioid treatment, and in patients who did not need rescue medication versus those who did.
  
  
  
  MBP is currently poorly managed in Spain. ECOG improvement is closely and directly related to pain management in MBP. Opioid treatment and a lack of requirements for rescue medication are associated with better ECOG and pain outcomes in MBP patients.
  
  
  
  Mundipharma Pharmaceuticals S.L.
authors.affiliation: Medical Oncology Department, Fundación Jiménez Díaz, Madrid, Spain. mdomine@fjd.es.
authors.forename: Manuel
authors.initials: M
authors.lastname: Dómine Gómez
authors.affiliation: Medical Oncology Department, Hospital San Juan de Alicante, Alicante, Spain.
authors.forename: Nieves
authors.initials: N
authors.lastname: Díaz Fernández
authors.affiliation: Medical Oncology Department, Hospital Puerta de Hierro de Majadahonda, Madrid, Spain.
authors.forename: Blanca
authors.initials: B
authors.lastname: Cantos Sánchez de Ibargüen
authors.affiliation: Radiation Oncology Department, Hospital de Povisa, Vigo, Pontevedra, Spain.
authors.forename: Luis
authors.initials: L
authors.lastname: Zugazabeitia Olabarría
authors.affiliation: Medical Oncology Department, Clínica Nuestra Señora de Belén, Murcia, Spain.
authors.forename: Joaquina
authors.initials: J
authors.lastname: Martínez Lozano
authors.affiliation: Radiation Oncology Department, Hospital Txagorritxu, Vitoria-Gasteiz, Álava, Spain.
authors.forename: Raúl
authors.initials: R
authors.lastname: Poza de Celis
authors.affiliation: Medical Oncology Department, Vithas Xanit Hospital Internacional, Málaga, Spain.
authors.forename: Rafael
authors.initials: R
authors.lastname: Trujillo Vílchez
authors.affiliation: Medical Oncology Department, Hospital de Cabueñes, Gijón, Asturias, Spain.
authors.forename: Ignacio
authors.initials: I
authors.lastname: Peláez Fernández
authors.affiliation: Medical Oncology Department, Hospital Vall d'Hebron, Barcelona, Spain.
authors.forename: Jaume
authors.initials: J
authors.lastname: Capdevila Castillón
authors.affiliation: Medical Department, Mundipharma Pharmaceuticals S.L., Madrid, Spain.
authors.forename: Susana
authors.initials: S
authors.lastname: Traseira Lugilde
authors.affiliation: Medical Oncology Department, Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain.
authors.forename: Emilio
authors.initials: E
authors.lastname: Esteban González
mesh_terms: D000368:Aged; D000700:Analgesics / Q000627:therapeutic use; D000701:Analgesics, Opioid / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000556:secondary*; D000072716:Cancer Pain / Q000188:drug therapy / Q000628:therapy*; D005260:Female; D006304:Health Status; D006801:Humans; D008297:Male; D008875:Middle Aged; D059408:Pain Management / Q000379:methods*; D011446:Prospective Studies; D013030:Spain
chemical_list: D000700:Analgesics; D000701:Analgesics, Opioid
keywords: Bone metastasis; Cancer; ECOG; Pain