title: Endoscopic Endonasal Management of Rare Sellar Lesions: Clinical and Surgical Experience of 78 Cases and Review of the Literature.
abstract: OBJECTIVE
  In the present study we aim to provide further definition of a group of rare sellar diseases treated by the endoscopic endonasal approach.
  
  
  METHODS
  The study was a retrospective analysis of data obtained from a series of 1729 patients who underwent endoscopic endonasal surgery at 2 academic institutions (Università degli Studi di Napoli Federico II, Naples, Italy between January 1997 and December 2013 and the Wexner Medical Center at The Ohio State University between July 2010 and September 2015). Clinical charts, operative notes, and pathology reports were examined.
  
  
  RESULTS
  A total of 346 cases were identified to have nonadenomatous diseases. Applying the Rosner test for outliers assisted in excluding relatively frequent lesions. The final cohort of rare sellar diseases comprised 78 patients. Arachnoid cysts were the most frequently encountered sellar lesion (12 patients, 15%), followed by metastasis (11 cases, 14%), followed by hypophysitis (8 cases, 10%), oncocytoma, and glioma (6 cases, 8% each). The most frequent clinical findings were headache (28%) and visual disorders (80%). A standard endoscopic endonasal approach was performed in 44 patients (56%), and an extended approach was carried out in 34 patients (44%). Tumor removal was gross total in 53% of patients, subtotal in 19%, and partial in 21%. Postoperative endocrinologic and visual deficit evaluation showed improvements in endocrine function in 8 patients (10%) and in visual disorders in 13 (16%). Postoperative complications arose in 28% of cases, mostly represented by diabetes insipidus (10%).
  
  
  CONCLUSIONS
  Endoscopic endonasal approaches offer some specific benefits in the treatment of these patients.
authors.affiliation: Division of Neurosurgery, Department of Neurosciences, Reproductive and Odontostomatological Sciences, Università degli Studi di Napoli Federico II, Naples, Italy. Electronic address: teresa.somma85@gmail.com.
authors.forename: Teresa
authors.initials: T
authors.lastname: Somma
authors.affiliation: Division of Neurosurgery, Department of Neurosciences, Reproductive and Odontostomatological Sciences, Università degli Studi di Napoli Federico II, Naples, Italy.
authors.forename: Domenico
authors.initials: D
authors.lastname: Solari
authors.affiliation: Department of Neurosurgery, Wexner Medical Center, Ohio State University, Columbus, OH, USA.
authors.forename: Andre
authors.initials: A
authors.lastname: Beer-Furlan
authors.affiliation: Division of Neurosurgery, Department of Neurosciences, Reproductive and Odontostomatological Sciences, Università degli Studi di Napoli Federico II, Naples, Italy.
authors.forename: Lelio
authors.initials: L
authors.lastname: Guida
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Wexner Medical Center, Ohio State University, Columbus, OH, USA.
authors.forename: Bradley
authors.initials: B
authors.lastname: Otto
authors.affiliation: Department of Neurosurgery, Wexner Medical Center, Ohio State University, Columbus, OH, USA.
authors.forename: Daniel
authors.initials: D
authors.lastname: Prevedello
authors.affiliation: Division of Neurosurgery, Department of Neurosciences, Reproductive and Odontostomatological Sciences, Università degli Studi di Napoli Federico II, Naples, Italy.
authors.forename: Luigi Maria
authors.initials: LM
authors.lastname: Cavallo
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Wexner Medical Center, Ohio State University, Columbus, OH, USA.
authors.forename: Ricardo
authors.initials: R
authors.lastname: Carrau
authors.affiliation: Division of Neurosurgery, Department of Neurosciences, Reproductive and Odontostomatological Sciences, Università degli Studi di Napoli Federico II, Naples, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Cappabianca
mesh_terms: D018249:Adenoma, Oxyphilic / Q000000981:diagnostic imaging / Q000601:surgery; D016080:Arachnoid Cysts / Q000000981:diagnostic imaging / Q000601:surgery; D015331:Cohort Studies; D019468:Disease Management; D005260:Female; D005910:Glioma / Q000000981:diagnostic imaging / Q000601:surgery; D006801:Humans; D000072659:Hypophysitis / Q000000981:diagnostic imaging / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009296:Nasal Cavity / Q000000981:diagnostic imaging* / Q000601:surgery*; D044583:Neuroendoscopy / Q000379:methods*; D012189:Retrospective Studies; D012658:Sella Turcica / Q000000981:diagnostic imaging* / Q000601:surgery*
keywords: Endoscopic endonasal approach; Rare tumors; Skull base surgery; Transsphenoidal sellar region