title: Simultaneous Chronoamperometric Sensing of Ascorbic Acid and Acetaminophen at a Boron-Doped Diamond Electrode.
abstract: Cyclic voltammetry (CV) and chronoamperometry (CA) have been used to sense and determine simultaneously L-ascorbic acid (AA) and acetaminophen (AC) at a boron-doped diamond electrode (BDDE) in a Britton-Robinson buffer solution. The calibration plots of anodic current peak versus concentration obtained from CV and CA data for both investigated compounds in single and di-component solutions over the concentration range 0.01 mM - 0.1 mM proved to be linear, with very good correlation parameters. Sensitivity values and RSD of 2-3% were obtained for various situations, involving both individual and simultaneous presence of AA and AC. The chronoamperometric technique associated with standard addition in sequential one step and/or two successive and continuous chronoamperograms at two characteristic potential levels represented a feasible option for the simultaneous determination of AA and AC in real sample systems such as pharmaceutical formulations. The average values indicated by the supplier were confirmed to a very close approximation from chronoamperomgrams by using several additions with the application of suitable current correction factors.
authors.affiliation: University of Medicine and Pharmacy "Victor Babes" Timisoara, PiaŃa E. Murgu, Nr. 2, 300041 Timisoara, Romania. cofancodruta@umft.ro.
authors.forename: Codruţa
authors.initials: C
authors.lastname: Cofan
authors.affiliation: West University of Timisoara, Laboratory of Electrochemistry, Str. Pestalozzi Nr.16, 300115 Timisoara, Romania. radovan@cbg.uvt.ro.
authors.forename: Ciprian
authors.initials: C
authors.lastname: Radovan
keywords: acetaminophen; ascorbic acid; boron-doped diamond electrode; buffered media.; chronoamperometry