title: MR Vascular Fingerprinting in Stroke and Brain Tumors Models.
abstract: In this study, we evaluated an MRI fingerprinting approach (MRvF) designed to provide high-resolution parametric maps of the microvascular architecture (i.e., blood volume fraction, vessel diameter) and function (blood oxygenation) simultaneously. The method was tested in rats (n = 115), divided in 3 models: brain tumors (9 L, C6, F98), permanent stroke, and a control group of healthy animals. We showed that fingerprinting can robustly distinguish between healthy and pathological brain tissues with different behaviors in tumor and stroke models. In particular, fingerprinting revealed that C6 and F98 glioma models have similar signatures while 9 L present a distinct evolution. We also showed that it is possible to improve the results of MRvF and obtain supplemental information by changing the numerical representation of the vascular network. Finally, good agreement was found between MRvF and conventional MR approaches in healthy tissues and in the C6, F98, and permanent stroke models. For the 9 L glioma model, fingerprinting showed blood oxygenation measurements that contradict results obtained with a quantitative BOLD approach. In conclusion, MR vascular fingerprinting seems to be an efficient technique to study microvascular properties in vivo. Multiple technical improvements are feasible and might improve diagnosis and management of brain diseases.
authors.affiliation: Univ. Grenoble Alpes, Grenoble Institut des Neurosciences, GIN, F-38000 Grenoble, France.|Inserm, U1216, F-38000 Grenoble, France.
authors.forename: B
authors.initials: B
authors.lastname: Lemasson
authors.affiliation: Center for Imaging of Neurodegenerative diseases, Veterans Affairs Medical Centrer, San Francisco, USA.|Department of Radiology, University of California San Francisco, San Francisco, CA, USA.
authors.forename: N
authors.initials: N
authors.lastname: Pannetier
authors.affiliation: Univ. Grenoble Alpes, Grenoble Institut des Neurosciences, GIN, F-38000 Grenoble, France.|Inserm, U1216, F-38000 Grenoble, France.
authors.forename: N
authors.initials: N
authors.lastname: Coquery
authors.affiliation: Univ. Grenoble Alpes, Grenoble Institut des Neurosciences, GIN, F-38000 Grenoble, France.|Inserm, U1216, F-38000 Grenoble, France.
authors.forename: Ligia S B
authors.initials: LSB
authors.lastname: Boisserand
authors.affiliation: Univ. Grenoble Alpes, Grenoble Institut des Neurosciences, GIN, F-38000 Grenoble, France.|Inserm, U1216, F-38000 Grenoble, France.
authors.forename: Nora
authors.initials: N
authors.lastname: Collomb
authors.affiliation: Center for Imaging of Neurodegenerative diseases, Veterans Affairs Medical Centrer, San Francisco, USA.|Department of Radiology, University of California San Francisco, San Francisco, CA, USA.
authors.forename: N
authors.initials: N
authors.lastname: Schuff
authors.affiliation: Department of Radiology, Stanford University, Stanford, California, USA.
authors.forename: M
authors.initials: M
authors.lastname: Moseley
authors.affiliation: Department of Radiology, Stanford University, Stanford, California, USA.
authors.forename: G
authors.initials: G
authors.lastname: Zaharchuk
authors.affiliation: Univ. Grenoble Alpes, Grenoble Institut des Neurosciences, GIN, F-38000 Grenoble, France.|Inserm, U1216, F-38000 Grenoble, France.
authors.forename: E L
authors.initials: EL
authors.lastname: Barbier
authors.affiliation: Department of Radiology, Stanford University, Stanford, California, USA.
authors.forename: T
authors.initials: T
authors.lastname: Christen
mesh_terms: D000818:Animals; D001921:Brain / Q000098:blood supply* / Q000000981:diagnostic imaging*; D001932:Brain Neoplasms / Q000000981:diagnostic imaging*; D045744:Cell Line, Tumor; D004195:Disease Models, Animal; D005910:Glioma / Q000000981:diagnostic imaging; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D055806:Microvessels / Q000000981:diagnostic imaging*; D011916:Rats, Inbred F344; D020521:Stroke / Q000000981:diagnostic imaging*