title: IL-8/IL-17 gene variations and the susceptibility to severe viral bronchiolitis.
abstract: Clinical manifestations of acute bronchiolitis (AB) vary from minimal disease to severe respiratory failure. The response to respiratory viral infections is possibly influenced by genetic polymorphisms linked to the regulation of the inflammatory response. In the present study, we investigated whether interleukin-8 (IL-8) and interleukin-17 (IL-17) genetic variants are associated with the severity of AB. A group of Brazilian infants hospitalized with AB and a control group (infants with no or mild AB, without hospitalization) were genotyped for four IL-8/IL-17 variations. For replication, we studied an Argentinean population sample of infants with mild and severe AB. IL-8 polymorphism (rs 2227543) and IL-17 (rs2275913) variants showed significant associations with the severity of AB. The effect of the IL-8 variation could be replicated in the Argentinean sample. This finding suggests that IL-8 variations may influence the severity of AB in young infants. Further genetic association studies in low- or middle-income populations are necessary with the aim of expanding knowledge in this area.
authors.affiliation: Aliança INFANT Argentina-Brasil.
authors.forename: L A
authors.initials: LA
authors.lastname: Pinto
authors.affiliation: Aliança INFANT Argentina-Brasil.
authors.forename: L A
authors.initials: LA
authors.lastname: DE Azeredo Leitão
authors.affiliation: Aliança INFANT Argentina-Brasil.
authors.forename: M
authors.initials: M
authors.lastname: Mocellin
authors.affiliation: Aliança INFANT Argentina-Brasil.
authors.forename: P
authors.initials: P
authors.lastname: Acosta
authors.affiliation: Aliança INFANT Argentina-Brasil.
authors.forename: M T
authors.initials: MT
authors.lastname: Caballero
authors.affiliation: Aliança INFANT Argentina-Brasil.
authors.forename: R
authors.initials: R
authors.lastname: Libster
authors.affiliation: Aliança INFANT Argentina-Brasil.
authors.forename: J E
authors.initials: JE
authors.lastname: Vargas
authors.affiliation: Aliança INFANT Argentina-Brasil.
authors.forename: F
authors.initials: F
authors.lastname: Polack
authors.affiliation: Aliança INFANT Argentina-Brasil.
authors.forename: T
authors.initials: T
authors.lastname: Comaru
authors.affiliation: Aliança INFANT Argentina-Brasil.
authors.forename: R T
authors.initials: RT
authors.lastname: Stein
authors.affiliation: Aliança INFANT Argentina-Brasil.
authors.forename: A P
authors.initials: AP
authors.lastname: DE Souza
mesh_terms: D001118:Argentina; D001938:Brazil; D001990:Bronchiolitis, Viral / Q000235:genetics* / Q000276:immunology*; D016022:Case-Control Studies; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D007223:Infant; D020381:Interleukin-17 / Q000235:genetics*; D016209:Interleukin-8 / Q000235:genetics*; D008297:Male; D020641:Polymorphism, Single Nucleotide; D012720:Severity of Illness Index
chemical_list: C508606:CXCL8 protein, human; D020381:Interleukin-17; D016209:Interleukin-8
keywords: Bronchiolitis; interleukin-8; polymorphism; severity; wheezing