title: Combining Cell and Gene Therapy in an Effort to Eradicate HIV.
abstract: More than 30 million people are infected with HIV, and HIV remains the fifth leading cause of disability-adjusted life years worldwide. Antiretroviral therapy (ART) dramatically decreases mortality rate, but there are side effects, long-term toxicities, expenses, stigmas, and inconveniences associated with chronic treatment, and HIV-infected individuals on ART have an increased risk of malignancies, cardiovascular disease, neurologic disease, and shortened life expectancy. Therefore, a cure for HIV remains an important goal. Combining new cell and gene therapy technology is an exciting approach that appears promising in vitro. Animal testing and careful clinical trials will be needed to determine if these strategies are clinically useful.
authors.affiliation: 1 Department of Pediatrics, University of Washington , Seattle, Washington.|2 Center for Global Infectious Disease Research, Seattle Children's Research Institute , Seattle, Washington.
authors.forename: Thor A
authors.initials: TA
authors.lastname: Wagner
mesh_terms: D000818:Animals; D064987:Cell- and Tissue-Based Therapy; D015316:Genetic Therapy; D015658:HIV Infections / Q000235:genetics / Q000628:therapy*; D015497:HIV-1 / Q000235:genetics*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans
keywords: CCR5; HIV; cell therapy; chimeric antigen receptor; gene therapy