title: ENDOPHTHALMITIS IN A PATIENT TREATED WITH BACILLUS CALMETTE-GUÉRIN IMMUNOTHERAPY.
abstract: BACKGROUND
  Intravesical Bacillus Calmette-Guérin (BCG) instillation has become one of the mainstays of adjunctive therapy in the treatment of superficial bladder cancer. Ophthalmologic complications are rare, but few cases are reported in the literature.
  
  
  METHODS
  Retrospective observational case report.
  
  
  RESULTS
  The authors report a case of unilateral Mycobacterium bovis BCG endophthalmitis after intravesical BCG instillations. Despite appropriate systemic antituberculous and corticosteroid therapy, the patient almost completely lost sight in the affected eye. This is the fourth case in the literature of proven M. bovis endophthalmitis suggesting a direct choroidal mycobacterial infection and not only a hypersensitivity immunologic reaction as previously suggested.
  
  
  CONCLUSIONS
  This case highlights the direct choroidal mycobacterial infection of the disease after BCG instillations for bladder cancer and failure of treatment despite culture-proven drug sensitivity, thus suggesting the need to revaluate adequate treatment to avoid loss of vision.
authors.affiliation: Department of Ophthalmology, Université de Montréal, Montreal, Quebec, Canada.|Department of Ophthalmology, Hôpital Maisonneuve-Rosemont, Montreal, Quebec, Canada.
authors.forename: Julie
authors.initials: J
authors.lastname: Vadboncoeur
authors.affiliation: Department of Ophthalmology, Université de Montréal, Montreal, Quebec, Canada.|Department of Ophthalmology, Hôpital Maisonneuve-Rosemont, Montreal, Quebec, Canada.
authors.forename: Sébastien
authors.initials: S
authors.lastname: Olivier
authors.affiliation: Laboratoire de santé publique du Québec (LSPQ), Montreal, Quebec, Canada.
authors.forename: Hafid
authors.initials: H
authors.lastname: Soualhine
authors.affiliation: Department of Microbiology, Infectious Diseases and Immunology, University of Montreal, Montreal, Quebec, Canada.|Service of Infectious Diseases and Medical Microbiology, Hôpital Maisonneuve-Rosemont, Montreal, Quebec, Canada.
authors.forename: Annie-Claude
authors.initials: AC
authors.lastname: Labbé
authors.affiliation: Department of Ophthalmology, Université de Montréal, Montreal, Quebec, Canada.|Department of Ophthalmology, Hôpital Maisonneuve-Rosemont, Montreal, Quebec, Canada.
authors.forename: Marie-Lyne
authors.initials: ML
authors.lastname: Bélair
mesh_terms: D000283:Administration, Intravesical; D000369:Aged, 80 and over; D001500:BCG Vaccine / Q000009:adverse effects*; D009877:Endophthalmitis / Q000209:etiology / Q000382:microbiology*; D015818:Eye Infections, Bacterial / Q000382:microbiology*; D006801:Humans; D007167:Immunotherapy / Q000009:adverse effects*; D008297:Male; D009164:Mycobacterium Infections / Q000382:microbiology*; D009163:Mycobacterium bovis; D012189:Retrospective Studies
chemical_list: D001500:BCG Vaccine