title: Obesity: A Perspective from Hypertension.
abstract: The prevalence of obesity-related hypertension is high worldwide and has become a major health issue. The mechanisms by which obesity relates to hypertensive disease are still under intense research scrutiny, and include altered hemodynamics, impaired sodium homeostasis, renal dysfunction, autonomic nervous system imbalance, endocrine alterations, oxidative stress and inflammation, and vascular injury. Most of these contributing factors interact with each other at multiple levels. Thus, as a multifactorial and complex disease, obesity-related hypertension should be recognized as a distinctive form of hypertension, and specific considerations should apply in planning therapeutic approaches to treat obese individuals with high blood pressure.
authors.affiliation: Hypertension Research Laboratory, Ochsner Clinic Foundation, 1514 Jefferson Highway New Orleans, Louisiana 70121, USA.
authors.forename: Dinko
authors.initials: D
authors.lastname: Susic
authors.affiliation: Hypertension & Vascular Research, Department of Surgery, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, North Carolina 27157, USA; Department of Physiology and Pharmacology, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, North Carolina 27157, USA. Electronic address: jvaragic@wakehealth.edu.
authors.forename: Jasmina
authors.initials: J
authors.lastname: Varagic
mesh_terms: D001341:Autonomic Nervous System / Q000503:physiopathology; D004703:Endocrine System / Q000503:physiopathology*; D006439:Hemodynamics; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology*; D009765:Obesity / Q000150:complications / Q000503:physiopathology*; D018384:Oxidative Stress; D012964:Sodium / Q000378:metabolism*
chemical_list: D012964:Sodium
keywords: Adipokines; Hypertension; Insulin resistance; Obesity; Renin-angiotensin-aldosterone system; Sodium; Sympathetic nervous system