title: Polyketides with Immunosuppressive Activities from Mangrove Endophytic Fungus Penicillium sp. ZJ-SY₂.
abstract: Nine polyketides, including two new benzophenone derivatives, peniphenone (1) and methyl peniphenone (2), along with seven known xanthones (3-9) were obtained from mangrove endophytic fungusPenicilliumsp. ZJ-SY₂ isolated from the leaves ofSonneratia apetala. Their structures were elucidated on the basis of MS, 1D, and 2D NMR data. Compounds1,3,5, and7showed potent immunosuppressive activity with IC50values ranging from 5.9 to 9.3 μg/mL.
authors.affiliation: School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China. liuhj8@mail2.sysu.edu.cn.|School of Pharmacy, Guangdong Medical University, Dongguan 523808, China. liuhj8@mail2.sysu.edu.cn.
authors.forename: Hongju
authors.initials: H
authors.lastname: Liu
authors.affiliation: School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China. chensh65@mail2.sysu.edu.cn.
authors.forename: Senhua
authors.initials: S
authors.lastname: Chen
authors.affiliation: School of Pharmacy, Guangdong Medical University, Dongguan 523808, China. liuwy79@yahoo.com.
authors.forename: Weiyang
authors.initials: W
authors.lastname: Liu
authors.affiliation: School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China. liuyayue@mail2.sysu.edu.cn.
authors.forename: Yayue
authors.initials: Y
authors.lastname: Liu
authors.affiliation: School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China. huangxishan13@foxmail.com.
authors.forename: Xishan
authors.initials: X
authors.lastname: Huang
authors.affiliation: School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China. cesshzhg@mail.sysu.edu.cn.|South China Sea Bio-Resource Exploitation and Utilization Collaborative Innovation Center, Guangzhou 510006, China. cesshzhg@mail.sysu.edu.cn.
authors.forename: Zhigang
authors.initials: Z
authors.lastname: She
mesh_terms: D000818:Animals; D001577:Benzophenones / Q000737:chemistry; D007166:Immunosuppressive Agents / Q000737:chemistry* / Q000494:pharmacology*; D029561:Lythraceae / Q000382:microbiology; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010407:Penicillium / Q000737:chemistry*; D018515:Plant Leaves / Q000382:microbiology; D061065:Polyketides / Q000737:chemistry* / Q000494:pharmacology*; D013141:Spiro Compounds / Q000737:chemistry; D014197:Trees / Q000382:microbiology; D044004:Xanthones / Q000737:chemistry
chemical_list: D001577:Benzophenones; D007166:Immunosuppressive Agents; D061065:Polyketides; D013141:Spiro Compounds; D044004:Xanthones; C047723:benzophenone
keywords: Penicillium sp.; immunosuppressive activity; marine fungus; polyketides