title: Exposure to phthalates in children aged 5-7years: Associations with thyroid function and insulin-like growth factors.
abstract: This study aimed to evaluate the associations between phthalate concentrations and thyroid function in preschool children. We collected demographic data and biological samples from 216 children aged 5-7years. We calculated urinary concentrations of eight mono-phthalate metabolites (mPAEs) separately for children from urban and rural areas and investigated their associations with thyroid function and growth hormones. mPAE concentrations were higher in children from the urban area than in those from the rural area, and most mPAEs were positively associated with free triiodothyronine and free thyroxine. The insulin-like growth factor 1 (IGF-1) concentration decreased 0.082ng/mL (95% confidence interval [CI]: -1.34, -0.113) with each 1ng/mL increase in monomethyl phthalate (MMP) and 0.132ng/mL (95% CI: -0.209, -0.055) with each 1ng/mL increase in mono-n-butyl phthalate. The insulin-like growth factor binding protein 3 concentration decreased by 0.01mg/L (95% CI: -0.001, -0.000) or 0.01mg/L (95% CI: -0.003, -0.000) with each 1ng/mL increase in MMP or monoethyl phthalate, respectively. Exposure to some phthalates at 5-7years of age might interfere with thyroid hormones and growth.
authors.affiliation: MOE Key Laboratory of Environment & Health, Institute of Environmental Medicine, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; School of Laboratory Medicine, Hubei University of Chinese Medicine, 1 Huangjia Lake West Road, Wuhan 430065, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wu
authors.affiliation: MOE Key Laboratory of Environment & Health, Institute of Environmental Medicine, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Zhou
authors.affiliation: MOE Key Laboratory of Environment & Health, Institute of Environmental Medicine, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Wang
authors.affiliation: School of Laboratory Medicine, Hubei University of Chinese Medicine, 1 Huangjia Lake West Road, Wuhan 430065, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Ning
authors.affiliation: Institute of Clinical Medicine, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, China. Electronic address: syanghb@163.com.
authors.forename: Jian-Ye
authors.initials: JY
authors.lastname: Yang
authors.affiliation: MOE Key Laboratory of Environment & Health, Institute of Environmental Medicine, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. Electronic address: zhouyk@mails.tjmu.edu.cn.
authors.forename: Yi-Kai
authors.initials: YK
authors.lastname: Zhou
mesh_terms: D002648:Child; D002675:Child, Preschool; D004781:Environmental Exposure / Q000706:statistics & numerical data*; D004785:Environmental Pollutants / Q000378:metabolism*; D005260:Female; D006801:Humans; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000378:metabolism; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D008297:Male; D010795:Phthalic Acids / Q000378:metabolism* / Q000633:toxicity; D013961:Thyroid Gland / Q000378:metabolism / Q000502:physiology*; D013963:Thyroid Hormones / Q000378:metabolism
chemical_list: D004785:Environmental Pollutants; C583557:IGF1 protein, human; D018972:Insulin-Like Growth Factor Binding Protein 3; D010795:Phthalic Acids; D013963:Thyroid Hormones; D007334:Insulin-Like Growth Factor I; C032279:phthalic acid
keywords: Insulin-like growth factor; Phthalate metabolite; Preschool children; Thyroid function