title: A case of distal extrahepatic cholangiocarcinoma with two positive resection margins.
abstract: Cholangiocarcinoma is an uncommon primary malignancy of the biliary tract that is challenging to diagnose and treat effectively due to its relatively silent and late clinical presentation. The present study reports a case of a 60-year-old male with distal extrahepatic cholangiocarcinoma with a 3-week history of painless obstructive jaundice symptoms and subjective weight loss. Imaging revealed an obstructing lesion in the common bile duct, just distal to the entrance of the cystic duct. Pathology revealed moderately differentiated cholangiocarcinoma with two positive proximal resection margins. The two positive resection margins presented a challenge during surgery and points to an urgent need for further studies to better illuminate diagnostic and therapeutic options for patients with similar clinicopathological presentation.
authors.affiliation: Division of Oncology, Siteman Cancer Center, Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
authors.forename: Wayne A
authors.initials: WA
authors.lastname: Warner
authors.affiliation: Department of Clinical Surgical Sciences, University of The West Indies, Eric Williams Medical Sciences Complex, Champ Fleurs, Trinidad and Tobago.
authors.forename: Wesley
authors.initials: W
authors.lastname: Ramcharan
authors.affiliation: Department of Clinical Surgical Sciences, University of The West Indies, Eric Williams Medical Sciences Complex, Champ Fleurs, Trinidad and Tobago.
authors.forename: Dave
authors.initials: D
authors.lastname: Harnanan
authors.affiliation: Department of Clinical Surgical Sciences, University of The West Indies, Eric Williams Medical Sciences Complex, Champ Fleurs, Trinidad and Tobago.
authors.forename: Srikanth
authors.initials: S
authors.lastname: Umakanthan
authors.affiliation: Department of Clinical Surgical Sciences, University of The West Indies, Eric Williams Medical Sciences Complex, Champ Fleurs, Trinidad and Tobago.
authors.forename: Ravi
authors.initials: R
authors.lastname: Maharaj
keywords: distal extrahepatic cholangiocarcinoma; pancreaticoduodenectomy; two positive proximal resection margins