title: Alkynyl-Containing Peptides of Marine Origin: A Review.
abstract: Since the 1990s, a number of terminal alkynyl residue-containing cyclic/acyclic peptides have been identified from marine organisms, especially cyanobacteria and marine mollusks. This review has presented 66 peptides, which covers over 90% marine peptides with terminal alkynyl fatty acyl units. In fact, more than 90% of these peptides described in the literature are of cyanobacterial origin. Interestingly, all the linear peptides featured with terminal alkyne were solely discovered from marine cyanobacteria. The objective of this article is to provide an overview on the types, structural characterization of these unusual terminal alkynyl fatty acyl units, as well as the sources and biological functions of their composed peptides. Many of these peptides have a variety of biological activities, including antitumor, antibacterial, antimalarial, etc. Further, we have also discussed the evident biosynthetic origin responsible for formation of terminal alkynes of natural PKS (polyketide synthase)/NRPS (nonribosome peptide synthetase) hybrids.
authors.affiliation: Research Center for Marine Drugs, Department of Pharmacy, State Key Laboratory of Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China. chaiqiuye123@sina.cn.|School of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang 330000, China. chaiqiuye123@sina.cn.
authors.forename: Qiu-Ye
authors.initials: QY
authors.lastname: Chai
authors.affiliation: Department of Pharmacy, Graduate School, Hunan University of Chinese Medicine, Changsha 410208, China. zyyangzhen1991@163.com.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Yang
authors.affiliation: Research Center for Marine Drugs, Department of Pharmacy, State Key Laboratory of Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China. franklin67@126.com.
authors.forename: Hou-Wen
authors.initials: HW
authors.lastname: Lin
authors.affiliation: Research Center for Marine Drugs, Department of Pharmacy, State Key Laboratory of Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China. hanbingnan@shsmu.edu.cn.
authors.forename: Bing-Nan
authors.initials: BN
authors.lastname: Han
mesh_terms: D000480:Alkynes / Q000737:chemistry* / Q000494:pharmacology; D059001:Aquatic Organisms / Q000737:chemistry*; D001688:Biological Products / Q000737:chemistry* / Q000494:pharmacology; D000458:Cyanobacteria / Q000737:chemistry; D006801:Humans; D010453:Peptide Synthases / Q000378:metabolism; D010455:Peptides / Q000737:chemistry* / Q000494:pharmacology; D048630:Polyketide Synthases / Q000378:metabolism
chemical_list: D000480:Alkynes; D001688:Biological Products; D010455:Peptides; D048630:Polyketide Synthases; D010453:Peptide Synthases
keywords: absolute configuration; alkynyl peptides; biological activity; marine cyanobacteria; mollusk