title: Effects of Nursing Interventions on Depression of Patients With Rheumatoid Arthritis: A Meta-Analysis of Randomized Controlled Trials.
abstract: Previous randomized controlled trials have led to conflicting findings regarding the effects of nursing interventions on depression of patients with rheumatoid arthritis (RA). The purpose of this study was to use the meta-analytic approach to resolve these discrepancies.
  
  
  
  We performed a systematic search of publications using MEDLINE, EMBASE, the Cochrane Library, and manual searches without language restrictions. Studies that met the following criteria were included: (1) randomized controlled trials; (2) duration of intervention≥4 weeks; (3) comparative control group; (4) adults with RA; (5) published studies in any language since reception; and (6) psychological symptoms assessed. We extracted relative risks (RRs) and 95% confidence internals (CIs) and pooled them using a random effect model. We carried out sensitivity analysis and assessed heterogeneity and publication bias.
  
  
  
  A total of 14 studies, including 1803 patients, were eligible for inclusion in the review. Depression symptom was assessed by questionnaires. In the pooled analysis, nursing interventions, including exercise training, medication guide, health education and psychotherapy were associated with the remission of depression (RR: -0.67; 95% CI: -0.89 to -0.46; P<0.01) with significant heterogeneity between studies (P<0.01).
  
  
  
  Nursing interventions may be important adjunctive therapies in the medical management of RA patients.
authors.affiliation: Medical School of Southeast University, Nanjing, Jiangsu, China. Electronic address: zhoubiyunzby@163.com.
authors.forename: Biyun
authors.initials: B
authors.lastname: Zhou
authors.affiliation: Zhongda Hospital Affiliated to Southeast University, Nanjing, Jiangsu, China.
authors.forename: Guohong
authors.initials: G
authors.lastname: Li
authors.affiliation: Medical School of Southeast University, Nanjing, Jiangsu, China.
authors.forename: Yuqun
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Medical School of Southeast University, Nanjing, Jiangsu, China.
authors.forename: Zihan
authors.initials: Z
authors.lastname: Zhao
mesh_terms: D001172:Arthritis, Rheumatoid / Q000523:psychology*; D003863:Depression / Q000451:nursing* / Q000523:psychology / Q000628:therapy*; D015444:Exercise; D006266:Health Education; D006801:Humans; D011613:Psychotherapy; D016032:Randomized Controlled Trials as Topic