title: Classification and Effects of Implant Surface Modification on the Bone: Human Cell-Based In Vitro Studies.
abstract: Implant surfaces are continuously being improved to achieve faster osseointegration and a stronger bone to implant interface. This review will present the various implant surfaces, the parameters for implant surface characterization, and the corresponding in vitro human cell-based studies determining the strength and quality of the bone-implant contact. These in vitro cell-based studies are the basis for animal and clinical studies and are the prelude to further reviews on how these surfaces would perform when subjected to the oral environment and functional loading.
authors.affiliation: 1   Temple University Kornberg School of Dentistry, Philadelphia, Pa.
authors.forename: Miriam
authors.initials: M
authors.lastname: Ting
authors.affiliation: 2   Department of Restorative Dentistry, Temple University Kornberg School of Dentistry, Philadelphia, Pa.
authors.forename: Steven R
authors.initials: SR
authors.lastname: Jefferies
authors.affiliation: 3   Department of Engineering Science, Uppsala University, Uppsala, Sweden.
authors.forename: Wei
authors.initials: W
authors.lastname: Xia
authors.affiliation: 3   Department of Engineering Science, Uppsala University, Uppsala, Sweden.
authors.forename: Håkan
authors.initials: H
authors.lastname: Engqvist
authors.affiliation: 4   Department of Periodontology and Oral Implantology, Temple University Kornberg School of Dentistry, Philadelphia, Pa.
authors.forename: Jon B
authors.initials: JB
authors.lastname: Suzuki
mesh_terms: D000818:Animals; D001842:Bone and Bones; D015921:Dental Implants; D006801:Humans; D016348:Osseointegration; D013499:Surface Properties; D014025:Titanium
chemical_list: D015921:Dental Implants; D014025:Titanium
keywords: dental implant; implant surface morphology; osseointegration; surface topography; titanium