title: Hypoxia-Inducible Factor-1αExpression in Indonesian Laryngeal Squamous Cell Carcinoma Patients.
abstract: Objectives. This research aimed to determine the association between hypoxia-inducible factor-1α(HIF-1α) expression and laryngeal squamous cell carcinoma clinical stage.Methods. We retrospectively analyzed paraffin-embedded tissue from 47 laryngeal squamous cell carcinoma (LSCC) patients from 2011 to 2014. HIF-1αexpression was analyzed by immunohistochemistry using an anti-HIF-1αmouse monoclonal antibody. The association between HIF-1αexpression and clinical stage was analyzed using the chi square test.Results. The glottis was the predominant site of laryngeal squamous cell carcinoma occurrence, and 43/47 (91.5%) patients presented at an advanced stage. Of the advanced stage patients, 27/43 stained positive for HIF-1αexpression and 16/43 stained negative. Of the early stage patients, 2/4 stained positive for HIF-1αexpression and 2/4 stained negative. Statistical analysis did not demonstrate significant association of HIF-1αexpression.Conclusion. There was no statistically significant association between HIF-1αexpression and the clinical stage or histological differentiation of LSCC.
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia.
authors.forename: Agus
authors.identifier: 0000-0003-3363-4563
authors.initials: A
authors.lastname: Surono
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia.
authors.forename: Priyanto
authors.initials: P
authors.lastname: Priyanto
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia.
authors.forename: Sagung Rai
authors.initials: SR
authors.lastname: Indrasari