title: pH-responsive polymeric micelles with core-shell-corona architectures as intracellular anti-cancer drug carriers.
abstract: Polymeric micelles with core-shell-corona nanoarchitecture were designed for intracellular therapeutic anti-cancer drug carriers. Poly(styrene-b-acrylic acid-b-ethylene glycol) (PS-b-PAA-b-PEG) asymmetric triblock copolymer underwent self-assembly in aqueous solution to form spherical micelles with hydrophobic PS core, anionic PAA shell and hydrophilic PEG corona. The anti-cancer drug (doxorubicin, DOX) was successfully incorporated into the polymeric micelles. Thein vitrorelease experiment confirmed that the release of DOX from the micelles was inhibited at pH 7.4. In contrast, an accelerated release of DOX was observed at mildly acidic conditions such as pH 4.5. The excellent biocompatibility of our PS-b-PAA-b-PEG-based micelles made the synthesized nano-carrier best suited for the delivery of anti-cancer drugs.
authors.affiliation: World Premier International (WPI) Research Center for Materials, Nanoarchitectonics (MANA), National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba, Ibaraki 305-0044, Japan.
authors.forename: Bishnu Prasad
authors.initials: BP
authors.lastname: Bastakoti
authors.affiliation: Department of Chemical Engineering, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei 10617, Taiwan.
authors.forename: Shih-Hsiang
authors.initials: SH
authors.lastname: Liao
authors.affiliation: Department of Materials Science and Chemistry, University of Hyogo, 2167 Shosha, Himeji 671-2280, Japan.
authors.forename: Masamichi
authors.initials: M
authors.lastname: Inoue
authors.affiliation: Department of Materials Science and Chemistry, University of Hyogo, 2167 Shosha, Himeji 671-2280, Japan.
authors.forename: Shin-Ichi
authors.initials: SI
authors.lastname: Yusa
authors.affiliation: World Premier International (WPI) Research Center for Materials, Nanoarchitectonics (MANA), National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba, Ibaraki 305-0044, Japan.
authors.forename: Masataka
authors.initials: M
authors.lastname: Imura
authors.affiliation: Department of Chemistry, Faculty of Science and Engineering, Saga University, 1 Honjo-machi, Saga 840-8502, Japan.
authors.forename: Kenichi
authors.initials: K
authors.lastname: Nakashima
authors.affiliation: Department of Chemical Engineering, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei 10617, Taiwan; Division of Medical Engineering Research, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli County 350, Taiwan.
authors.forename: Kevin C-W
authors.initials: KC
authors.lastname: Wu
authors.affiliation: World Premier International (WPI) Research Center for Materials, Nanoarchitectonics (MANA), National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba, Ibaraki 305-0044, Japan; Faculty of Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku, Tokyo 169-8555, Japan; Precursory Research for Embryonic Science and Technology (PRESTO), Japan Science and Technology Agency (JST), 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Yamauchi
keywords: 10.01; 10.13; anti-cancer drug carrier; block copolymer; core–shell–corona micelle; doxorubicin; frozen micelle