title: Waterborne aripiprazole blunts the stress response in zebrafish.
abstract: Here we provide, at least to our knowledge, the first evidence that aripiprazole (APPZ) in the water blunts the stress response of exposed fish in a concentration ten times lower than the concentration detected in the environment. Although the mechanism of APPZ in the neuroendocrine axis is not yet determined, our results highlight that the presence of APPZ residues in the environment may interfere with the stress responses in fish. Since an adequate stress response is crucial to restore fish homeostasis after stressors, fish with impaired stress response may have trouble to cope with natural and/or imposed stressors with consequences to their welfare and survival.
authors.affiliation: Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria (UFSM), Av. Roraima, 1000, Cidade Universitária, Camobi, Santa Maria, RS, 97105-900, Brazil.|Universidade de Passo Fundo (UPF), BR 285, São José, Passo Fundo, RS, 99052-900, Brazil.
authors.forename: Heloísa Helena de Alcantara
authors.initials: HH
authors.lastname: Barcellos
authors.affiliation: Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria (UFSM), Av. Roraima, 1000, Cidade Universitária, Camobi, Santa Maria, RS, 97105-900, Brazil.
authors.forename: Fabiana
authors.initials: F
authors.lastname: Kalichak
authors.affiliation: Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria (UFSM), Av. Roraima, 1000, Cidade Universitária, Camobi, Santa Maria, RS, 97105-900, Brazil.
authors.forename: João Gabriel Santos
authors.initials: JG
authors.lastname: da Rosa
authors.affiliation: Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria (UFSM), Av. Roraima, 1000, Cidade Universitária, Camobi, Santa Maria, RS, 97105-900, Brazil.
authors.forename: Thiago Acosta
authors.initials: TA
authors.lastname: Oliveira
authors.affiliation: Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria (UFSM), Av. Roraima, 1000, Cidade Universitária, Camobi, Santa Maria, RS, 97105-900, Brazil.
authors.forename: Gessi
authors.initials: G
authors.lastname: Koakoski
authors.affiliation: Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria (UFSM), Av. Roraima, 1000, Cidade Universitária, Camobi, Santa Maria, RS, 97105-900, Brazil.|Universidade de Passo Fundo (UPF), BR 285, São José, Passo Fundo, RS, 99052-900, Brazil.
authors.forename: Renan
authors.initials: R
authors.lastname: Idalencio
authors.affiliation: Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria (UFSM), Av. Roraima, 1000, Cidade Universitária, Camobi, Santa Maria, RS, 97105-900, Brazil.
authors.forename: Murilo Sander
authors.initials: MS
authors.lastname: de Abreu
authors.affiliation: Universidade de Passo Fundo (UPF), BR 285, São José, Passo Fundo, RS, 99052-900, Brazil.
authors.forename: Ana Cristina Varrone
authors.initials: AC
authors.lastname: Giacomini
authors.affiliation: Universidade de Passo Fundo (UPF), BR 285, São José, Passo Fundo, RS, 99052-900, Brazil.
authors.forename: Michele
authors.initials: M
authors.lastname: Fagundes
authors.affiliation: Universidade de Passo Fundo (UPF), BR 285, São José, Passo Fundo, RS, 99052-900, Brazil.
authors.forename: Cristiane
authors.initials: C
authors.lastname: Variani
authors.affiliation: Universidade de Passo Fundo (UPF), BR 285, São José, Passo Fundo, RS, 99052-900, Brazil.
authors.forename: Mainara
authors.initials: M
authors.lastname: Rossini
authors.affiliation: Programa de Pós-Graduação em Farmacologia e Terapêutica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, 90050-170, Brasil.
authors.forename: Angelo L
authors.initials: AL
authors.lastname: Piato
authors.affiliation: Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria (UFSM), Av. Roraima, 1000, Cidade Universitária, Camobi, Santa Maria, RS, 97105-900, Brazil.|Universidade de Passo Fundo (UPF), BR 285, São José, Passo Fundo, RS, 99052-900, Brazil.|Programa de Pós-Graduação em Bioexperimentação, Universidade de Passo Fundo (UPF), BR 285, São José, Passo Fundo, RS, 99052-900, Brazil.
authors.forename: Leonardo José Gil
authors.initials: LJ
authors.lastname: Barcellos
mesh_terms: D000818:Animals; D000068180:Aripiprazole / Q000633:toxicity*; D005260:Female; D006854:Hydrocortisone / Q000378:metabolism; D008297:Male; D013312:Stress, Physiological / Q000187:drug effects*; D014874:Water Pollutants, Chemical / Q000633:toxicity*; D015027:Zebrafish / Q000502:physiology*
chemical_list: D014874:Water Pollutants, Chemical; D000068180:Aripiprazole; D006854:Hydrocortisone