title: G4IPDB: A database for G-quadruplex structure forming nucleic acid interacting proteins.
abstract: Nucleic acid G-quadruplex structure (G4) Interacting Proteins DataBase (G4IPDB) is an important database that contains detailed information about proteins interacting with nucleic acids that forms G-quadruplex structures. G4IPDB is the first database that provides comprehensive information about this interaction at a single platform. This database contains more than 200 entries with details of interaction such as interacting protein name and their synonyms, their UniProt-ID, source organism, target name and its sequences, ∆Tm, binding/dissociation constants, protein gene name, protein FASTA sequence, interacting residue in protein, related PDB entries, interaction ID, graphical view, PMID, author's name and techniques that were used to detect their interactions. G4IPDB also provides an efficient web-based "G-quadruplex predictor tool" that searches putative G-quadruplex forming sequences simultaneously in both sense and anti-sense strands of the query nucleotide sequence and provides the predicted G score. Studying the interaction between proteins and nucleic acids forming G-quadruplex structures could be of therapeutic significance for various diseases including cancer and neurological disease, therefore, having detail information about their interactions on a single platform would be helpful for the discovery and development of novel therapeutics. G4IPDB can be routinely updated (twice in year) and freely available on http://bsbe.iiti.ac.in/bsbe/ipdb/index.php.
authors.affiliation: Centre for Biosciences and Biomedical Engineering, Indian Institute of Technology Indore, Indore, Madhya Pradesh, 453552, India.
authors.forename: Subodh Kumar
authors.initials: SK
authors.lastname: Mishra
authors.affiliation: Centre for Biosciences and Biomedical Engineering, Indian Institute of Technology Indore, Indore, Madhya Pradesh, 453552, India.
authors.forename: Arpita
authors.initials: A
authors.lastname: Tawani
authors.affiliation: Cellular and Molecular Neurobiology Unit, Indian Institute of Technology, Jodhpur, Rajasthan, 342011, India.
authors.forename: Amit
authors.initials: A
authors.lastname: Mishra
authors.affiliation: Centre for Biosciences and Biomedical Engineering, Indian Institute of Technology Indore, Indore, Madhya Pradesh, 453552, India.
authors.forename: Amit
authors.initials: A
authors.lastname: Kumar
mesh_terms: D004268:DNA-Binding Proteins; D030562:Databases, Protein; D054856:G-Quadruplexes; D006801:Humans; D020407:Internet; D016601:RNA-Binding Proteins; D014584:User-Computer Interface
chemical_list: D004268:DNA-Binding Proteins; D016601:RNA-Binding Proteins