title: Results from the Workshop "Problem Formulation for the Use of Gene Drive in Mosquitoes".
abstract: Reducing the incidence of malaria has been a public health priority for nearly a century. New technologies and associated vector control strategies play an important role in the prospect of sustained reductions. The development of the CRISPR/Cas9 gene editing system has generated new possibilities for the use of gene-drive constructs to reduce or alter vector populations to reduce malaria incidence. However, before these technologies can be developed and exploited, it will be necessary to understand and assess the likelihood of any potential harms to humans or the environment. To begin this process, the Foundation for the National Institutes of Health and the International Life Sciences Institute Research Foundation organized an expert workshop to consider the potential risks related to the use of gene drives inAnopheles gambiaefor malaria control in Africa. The resulting discussion yielded a series of consensus points that are reported here.
authors.affiliation: Center for Environmental Risk Assessment, International Life Sciences Institute Research Foundation, Washington, District of Columbia.
authors.forename: Andrew
authors.initials: A
authors.lastname: Roberts
authors.affiliation: Department of Genetics, Federal University of Pernambuco, Recife, Brazil.
authors.forename: Paulo Paes de
authors.initials: PP
authors.lastname: Andrade
authors.affiliation: Ifakara Health Institute, Environmental Health and Ecological Sciences Thematic Group, Dar es Salaam, Tanzania.
authors.forename: Fredros
authors.initials: F
authors.lastname: Okumu
authors.affiliation: Institute for International Crop Improvement, Donald Danforth Plant Science Center, Saint Louis, Missouri.
authors.forename: Hector
authors.initials: H
authors.lastname: Quemada
authors.affiliation: African Biosafety Network of Expertise, NEPAD Agency, Ouagadougou Node, University of Ouagadougou, Burkina Faso.
authors.forename: Moussa
authors.initials: M
authors.lastname: Savadogo
authors.affiliation: Dalla Lana School of Public Health, University of Toronto, Ontario, Canada.|Centre for the AIDS Programme of Research in South Africa, University of KwaZulu-Natal, Durban, South Africa.
authors.forename: Jerome Amir
authors.initials: JA
authors.lastname: Singh
authors.affiliation: Foundation for the National Institutes of Health, Bethesda, Maryland.
authors.forename: Stephanie
authors.initials: S
authors.lastname: James
mesh_terms: D000349:Africa / Q000453:epidemiology; D000818:Animals; D000852:Anopheles / Q000187:drug effects / Q000235:genetics*; D044822:Biodiversity; D064113:CRISPR-Cas Systems / Q000235:genetics; D064112:Clustered Regularly Interspaced Short Palindromic Repeats / Q000235:genetics; D003226:Congresses as Topic; D006801:Humans; D015994:Incidence; D007303:Insect Vectors / Q000235:genetics; D007306:Insecticides / Q000494:pharmacology; D008288:Malaria / Q000453:epidemiology* / Q000517:prevention & control / Q000635:transmission; D009032:Mosquito Control / Q000379:methods*; D011634:Public Health; D012107:Research Design; D018570:Risk Assessment
chemical_list: D007306:Insecticides