title: Genetic polymorphisms of FAS and EVER genes in a Greek population and their susceptibility to cervical cancer: a case control study.
abstract: The aim of the study was to evaluate the association of two SNPs of EVER1/2 genes' region (rs2290907, rs16970849) and the FAS-670 polymorphism with the susceptibility to precancerous lesions and cervical cancer in a Greek population.
  
  
  
  Among the 515 women who were included in the statistical analysis, 113 belong to the case group and present with precancerous lesions or cervical cancer (27 with persistent CIN1, 66 with CIN2/3 and 20 with cervical cancer) and 402 belong to the control group. The chi-squared test was used to compare the case and the control groups with an allelic and a genotype-based analysis.
  
  
  
  The results of the statistical analysis comparing the case and the control groups for all the SNPs tested were not statistically significant. Borderline significant difference (p value = 0.079) was only found by the allelic model between the control group and the CIN1/CIN2 patients' subgroup for the polymorphism rs16970849. The comparison of the other case subgroups with the control group did not show any statistically significant difference.
  
  
  
  None of the SNPs included in the study can be associated with statistical significance with the development of precancerous lesions or cervical cancer.
authors.affiliation: Department of Gynaecology and Obstetrics, Geneva University Hospitals , Geneva, Switzerland. pavlidou.evangelia@gmail.com.|4th University Clinic of Obstetrics and Gynecology, Aristotle University of Thessaloniki, "Hippokrateion" General Hospital of Thessaloniki, Thessaloniki, Greece. pavlidou.evangelia@gmail.com.
authors.forename: Evangelia
authors.identifier: 0000-0002-7906-8977
authors.initials: E
authors.lastname: Pavlidou
authors.affiliation: Department of Obstetrics and Gynaecology, Faculty of Medicine, University of Thessaly, University Hospital of Larissa, Larissa, Greece.
authors.forename: Alexandros
authors.initials: A
authors.lastname: Daponte
authors.affiliation: Institut de Biotecnologia i Biomedicina/Departament de Genètica i de Microbiologia, Universitat Autònoma Barcelona, 08192, Cerdanyola, Barcelona, Spain.
authors.forename: Raquel
authors.initials: R
authors.lastname: Egea
authors.affiliation: Department of Neurology, Laboratory of Neurogenetics, Faculty of Medicine, University of Thessaly, University Hospital of Larissa, Larissa, Greece.
authors.forename: Efthimios
authors.initials: E
authors.lastname: Dardiotis
authors.affiliation: Department of Neurology, Laboratory of Neurogenetics, Faculty of Medicine, University of Thessaly, University Hospital of Larissa, Larissa, Greece.
authors.forename: Georgios M
authors.initials: GM
authors.lastname: Hadjigeorgiou
authors.affiliation: Institut de Biotecnologia i Biomedicina/Departament de Genètica i de Microbiologia, Universitat Autònoma Barcelona, 08192, Cerdanyola, Barcelona, Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: Barbadilla
authors.affiliation: 4th University Clinic of Obstetrics and Gynecology, Aristotle University of Thessaloniki, "Hippokrateion" General Hospital of Thessaloniki, Thessaloniki, Greece.
authors.forename: Theodoros
authors.initials: T
authors.lastname: Agorastos
mesh_terms: D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006115:Greece; D006801:Humans; D015810:Linkage Disequilibrium; D008565:Membrane Proteins / Q000235:genetics*; D008875:Middle Aged; D009367:Neoplasm Staging; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D002583:Uterine Cervical Neoplasms / Q000235:genetics* / Q000473:pathology; D019014:fas Receptor / Q000235:genetics*
chemical_list: D008565:Membrane Proteins; C470314:TMC6 protein, human; C470315:TMC8 protein, human; D019014:fas Receptor
keywords: Cervical cancer; EVER; FAS; Polymorphism