title: Successful treatment of a 67-year-old woman with urethral adenocarcinoma with the use of external beam radiotherapy and image guided adaptive interstitial brachytherapy.
abstract: Primary urethral cancer (PUC) is a very rare disease. This case report illustrates a successful treatment approach of a 67-year-old woman with a urethral adenocarcinoma selected for an organ preserving treatment with external beam radiotherapy (EBRT) and interstitial brachytherapy (BT) boost, using the GEC-ESTRO target concept originally designed for locally advanced cervical cancer (LACC). Treatment included EBRT with 45 Gy in 25 fractions followed by image guided adaptive interstitial BT (IGABT) with a pulsed-dose-rate (PDR) BT boost with 30 Gy in 50 hourly pulses. The D90for CTVHRwas 79.1 Gy in EQD23. At 24 months follow-up, the patient was recurrence free and without treatment related side effects.
authors.affiliation: Department of Oncology.
authors.forename: Jasmin
authors.initials: J
authors.lastname: Mujkanovic
authors.affiliation: Department of Oncology.
authors.forename: Kari
authors.initials: K
authors.lastname: Tanderup
authors.affiliation: Department of Oncology.
authors.forename: Mads
authors.initials: M
authors.lastname: Agerbæk
authors.affiliation: Department of Urology.
authors.forename: Ulla
authors.initials: U
authors.lastname: Bisgaard
authors.affiliation: Department of Pathology, Aarhus University Hospital, Århus, Denmark.
authors.forename: Søren
authors.initials: S
authors.lastname: Høyer
authors.affiliation: Department of Oncology.
authors.forename: Jacob Christian
authors.initials: JC
authors.lastname: Lindegaard
authors.affiliation: Department of Oncology.
authors.forename: Lars
authors.initials: L
authors.lastname: Fokdal
keywords: interstitial brachytherapy; primary urethral cancer; radiotherapy