title: Fe-Catalyzed Amination of (Hetero)Arenes with a Redox-Active Aminating Reagent under Mild Conditions.
abstract: A novel and efficient Fe-catalyzed direct C-H amination (NH2) of arenes is reported using a new redox-active aminating reagent. The reaction is simple, and can be performed under air, mild, and redox-neutral conditions. This protocol has a broad substrate scope and could be used in the late-stage modification of bioactive compounds. Mechanistic studies demonstrate that a radical pathway could be involved in this transformation.
authors.affiliation: State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences Peking University, Xue Yuan Rd. 38, Beijing, 100191, P. R. China.
authors.forename: Jianzhong
authors.initials: J
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences Peking University, Xue Yuan Rd. 38, Beijing, 100191, P. R. China.
authors.forename: Kai
authors.initials: K
authors.lastname: Wu
authors.affiliation: State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences Peking University, Xue Yuan Rd. 38, Beijing, 100191, P. R. China.
authors.forename: Tao
authors.initials: T
authors.lastname: Shen
authors.affiliation: State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences Peking University, Xue Yuan Rd. 38, Beijing, 100191, P. R. China.
authors.forename: Yujie
authors.initials: Y
authors.lastname: Liang
authors.affiliation: State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences Peking University, Xue Yuan Rd. 38, Beijing, 100191, P. R. China.
authors.forename: Miancheng
authors.initials: M
authors.lastname: Zou
authors.affiliation: State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences Peking University, Xue Yuan Rd. 38, Beijing, 100191, P. R. China.
authors.forename: Yuchao
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences Peking University, Xue Yuan Rd. 38, Beijing, 100191, P. R. China.
authors.forename: Xinwei
authors.initials: X
authors.lastname: Li
authors.affiliation: State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences Peking University, Xue Yuan Rd. 38, Beijing, 100191, P. R. China.
authors.forename: Xinyao
authors.initials: X
authors.lastname: Li
authors.affiliation: State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences Peking University, Xue Yuan Rd. 38, Beijing, 100191, P. R. China.|State Key Laboratory of Organometallic Chemistry, Chinese Academy of Sciences, Shanghai, 200032, P. R. China.
authors.forename: Ning
authors.initials: N
authors.lastname: Jiao
keywords: C−H functionalization; amination; iron; new reagents; radical