title: Photo-decomposable Organic Nanoparticles for Combined Tumor Optical Imaging and Multiple Phototherapies.
abstract: Combination of photodynamic therapy (PDT) with photothermal therapy (PTT) has achieved significantly improved therapeutic efficacy compared to a single phototherapy modality. However, most nanomaterials used for combined PDT/PTT are made of non-biodegradable materials (e.g., gold nanorods, carbon nanotubes, and graphenes) and may remain intact in the body for long time, raising concerns over their potential long-term toxicity. Here we report a new combined PDT/PTT nanomedicine, designated SP3NPs, that exhibit photo-decomposable, photodynamic and photothermal properties. SP3NPs were prepared by self-assembly of PEGylated cypate, comprising FDA-approved PEG and an ICG derivative. We confirmed the ability of SP3NPs to generate both singlet oxygen for a photodynamic effect and heat for photothermal therapy in response to NIR laser irradiation in vitro. Also, the unique ability of SP3NPs to undergo irreversible decomposition upon NIR laser irradiation was demonstrated. Further our experimental results demonstrated that SP3NPs strongly accumulated in tumor tissue owing to their highly PEGylated surface and relatively small size (~60 nm), offering subsequent imaging-guided combined PDT/PTT treatment that resulted in tumor eradication and prolonged survival of mice. Taken together, our SP3NPs described here may represent a novel and facile approach for next-generation theranostics with great promise for translation into clinical practice in the future.
authors.affiliation: KAIST Institute for the BioCentury, Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejon 305-701, Republic of Korea.; School of Pharmaceutical Science, Nanjing Tech University, Nanjing, 211816, China.
authors.forename: Wenjun
authors.initials: W
authors.lastname: Miao
authors.affiliation: KAIST Institute for the BioCentury, Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejon 305-701, Republic of Korea.
authors.forename: Hyungjun
authors.initials: H
authors.lastname: Kim
authors.affiliation: KAIST Institute for the BioCentury, Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejon 305-701, Republic of Korea.
authors.forename: Vipul
authors.initials: V
authors.lastname: Gujrati
authors.affiliation: Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejon 305-701, Republic of Korea.
authors.forename: Jin Yong
authors.initials: JY
authors.lastname: Kim
authors.affiliation: KAIST Institute for the BioCentury, Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejon 305-701, Republic of Korea.
authors.forename: Hyeongsu
authors.initials: H
authors.lastname: Jon
authors.affiliation: KAIST Institute for the BioCentury, Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejon 305-701, Republic of Korea.
authors.forename: Yonghyun
authors.initials: Y
authors.lastname: Lee
authors.affiliation: KAIST Institute for the BioCentury, Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejon 305-701, Republic of Korea.
authors.forename: Minsuk
authors.initials: M
authors.lastname: Choi
authors.affiliation: KAIST Institute for the BioCentury, Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejon 305-701, Republic of Korea.
authors.forename: Jinjoo
authors.initials: J
authors.lastname: Kim
authors.affiliation: KAIST Institute for the BioCentury, Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejon 305-701, Republic of Korea.
authors.forename: Soyoung
authors.initials: S
authors.lastname: Lee
authors.affiliation: Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejon 305-701, Republic of Korea.
authors.forename: Dong Yun
authors.initials: DY
authors.lastname: Lee
authors.affiliation: KAIST Institute for the BioCentury, Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejon 305-701, Republic of Korea.
authors.forename: Sukmo
authors.initials: S
authors.lastname: Kang
authors.affiliation: KAIST Institute for the BioCentury, Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejon 305-701, Republic of Korea.; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejon 305-701, Republic of Korea.
authors.forename: Sangyong
authors.initials: S
authors.lastname: Jon
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D064593:Heterografts; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D007259:Infrared Rays; D007834:Lasers; D008545:Melanoma / Q000175:diagnosis* / Q000628:therapy*; D051379:Mice; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry*; D061848:Optical Imaging / Q000379:methods*; D010789:Phototherapy / Q000379:methods*; D016896:Treatment Outcome
keywords: nanomedicine · indocyanine green · photodynamic therapy · photothermal therapy · theranostics.