title: Metachronous Uterine Endometrioid Adenocarcinoma and Peritoneal Mesothelioma in Lynch Syndrome: A Case Report.
abstract: Lynch syndrome is a hereditary disease with germline mutation in a DNA mismatch repair gene, most often presenting with colorectal and/or endometrial carcinomas; however, the spectrum of Lynch syndrome-associated tumors is expanding. In this article, we report a case of a primary peritoneal epithelioid mesothelioma that developed in a Lynch syndrome patient 10 months after diagnosis of uterine endometrioid adenocarcinoma. To our knowledge, this is the first reported case of a Lynch syndrome patient with metachronous uterine endometrioid adenocarcinoma and primary peritoneal mesothelioma.
authors.affiliation: 1 University of California Irvine Medical Center, Irvine, CA, USA.
authors.forename: Yuxin
authors.initials: Y
authors.lastname: Lu
authors.affiliation: 2 University of Texas Southwestern Medical Center, Dallas, TX, USA.
authors.forename: Sara
authors.initials: S
authors.lastname: Milchgrub
authors.affiliation: 2 University of Texas Southwestern Medical Center, Dallas, TX, USA.
authors.forename: Gaurav
authors.initials: G
authors.lastname: Khatri
authors.affiliation: 2 University of Texas Southwestern Medical Center, Dallas, TX, USA.
authors.forename: Purva
authors.initials: P
authors.lastname: Gopal
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D018269:Carcinoma, Endometrioid / Q000209:etiology / Q000473:pathology*; D004268:DNA-Binding Proteins / Q000235:genetics; D005260:Female; D018095:Germ-Line Mutation; D006801:Humans; D007150:Immunohistochemistry; D055847:Lynch Syndrome II / Q000150:complications / Q000235:genetics / Q000473:pathology*; D008875:Middle Aged; D018301:Neoplasms, Mesothelial / Q000209:etiology / Q000473:pathology*; D010534:Peritoneal Neoplasms / Q000209:etiology / Q000473:pathology*; D014594:Uterine Neoplasms / Q000209:etiology / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor; D004268:DNA-Binding Proteins; C094443:G-T mismatch-binding protein
keywords: Lynch syndrome; endometrioid adenocarcinoma; peritoneal mesothelioma