title: IQGAP1 makes PI(3)K signalling as easy as PIP, PIP2, PIP3.
abstract: Despite being one of the most studied signalling pathways, precisely how phospholipid synthesis is regulated in the phosphoinositide signalling cascade remains unclear. The scaffold protein IQGAP1 is now shown to orchestrate the assembly of a multi-enzyme complex that streamlines PtdIns(3,4,5)P3synthesis to facilitate Akt activation in response to extracellular stimuli.
authors.affiliation: Department of Medicine, Boston University School of Medicine, 650 Albany Street, Boston, Massachusetts 02118, USA.
authors.forename: Lucia E
authors.initials: LE
authors.lastname: Rameh
authors.affiliation: Schepens Eye Research Institute/Mass Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA.
authors.forename: Ashley M
authors.initials: AM
authors.lastname: Mackey
mesh_terms: D000818:Animals; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000378:metabolism; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism*; D018129:Phosphatidylinositol Phosphates / Q000378:metabolism*; D010766:Phosphorylation; D015398:Signal Transduction; D020703:ras GTPase-Activating Proteins / Q000378:metabolism*
chemical_list: C101203:IQ motif containing GTPase activating protein 1; D018129:Phosphatidylinositol Phosphates; D020703:ras GTPase-Activating Proteins; D019869:Phosphatidylinositol 3-Kinases