title: Knockdown of KLK11 inhibits cell proliferation and increases oxaliplatin sensitivity in human colorectal cancer.
abstract: It has been reported that kallikrein 11 (KLK11) is crucially involved in the development and progression of various types of cancer. However, the molecular mechanisms that underlie the involvement of KLK11 in aberrant colorectal cancer (CRC) cell growth remain largely unclear. The aim of the present study was to investigate the role of KLK11 and the effects of KLK11 on oxaliplatin (L-OHP) chemosensitivity by knocking down KLK11 in LOVO and HCT-8 cells. Loss-of-function assays revealed KLK11 inhibition significantly inhibited growth and induced apoptosis of CRC cellsin vitro. Notably, further experiments found that knockdown of KLK11 expression increased the L-OHP chemosensitivity of CRC cells. KLK11 inhibition of increased L-OHP-induced apoptosis may be associated with activation of caspase-3 cleavage and the apoptosis signaling pathway. The present results indicated that KLK11 may be an potential target of interest for future research into therapies for CRC.
authors.affiliation: Department of Colorectal Surgery, Union Hospital, Fujian Medical University, Fuzhou, Fujian 350001, P.R. China.
authors.forename: Zongbin
authors.initials: Z
authors.lastname: Xu
authors.affiliation: Department of Colorectal Surgery, Union Hospital, Fujian Medical University, Fuzhou, Fujian 350001, P.R. China.
authors.forename: Pan
authors.initials: P
authors.lastname: Chi
authors.affiliation: Department of Emergency Surgery, Union Hospital, Fujian Medical University, Fuzhou, Fujian 350001, P.R. China.
authors.forename: Jie
authors.initials: J
authors.lastname: Pan
authors.affiliation: Department of Medical Oncology, Union Hospital, Fujian Medical University, Fuzhou, Fujian 350001, P.R. China.
authors.forename: Songfei
authors.initials: S
authors.lastname: Shen
authors.affiliation: Department of Colorectal Surgery, Union Hospital, Fujian Medical University, Fuzhou, Fujian 350001, P.R. China.
authors.forename: Yanwu
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Department of Colorectal Surgery, Union Hospital, Fujian Medical University, Fuzhou, Fujian 350001, P.R. China.
authors.forename: Xiaojie
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Colorectal Surgery, Union Hospital, Fujian Medical University, Fuzhou, Fujian 350001, P.R. China.
authors.forename: Xingrong
authors.initials: X
authors.lastname: Lu
keywords: apoptosis; colorectal cancer; drug resistance; kallikrein 11; oxaliplatin