title: CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.
abstract: NCBI's Conserved Domain Database (CDD) aims at annotating biomolecular sequences with the location of evolutionarily conserved protein domain footprints, and functional sites inferred from such footprints. An archive of pre-computed domain annotation is maintained for proteins tracked by NCBI's Entrez database, and live search services are offered as well. CDD curation staff supplements a comprehensive collection of protein domain and protein family models, which have been imported from external providers, with representations of selected domain families that are curated in-house and organized into hierarchical classifications of functionally distinct families and sub-families. CDD also supports comparative analyses of protein families via conserved domain architectures, and a recent curation effort focuses on providing functional characterizations of distinct subfamily architectures using SPARCLE: Subfamily Protein Architecture Labeling Engine. CDD can be accessed at https://www.ncbi.nlm.nih.gov/Structure/cdd/cdd.shtml.
authors.affiliation: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bldg. 38 A, Room 8N805, 8600 Rockville Pike, Bethesda, MD 20894, USA bauer@ncbi.nlm.nih.gov.
authors.forename: Aron
authors.initials: A
authors.lastname: Marchler-Bauer
authors.affiliation: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bldg. 38 A, Room 8N805, 8600 Rockville Pike, Bethesda, MD 20894, USA.
authors.forename: Yu
authors.initials: Y
authors.lastname: Bo
authors.affiliation: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bldg. 38 A, Room 8N805, 8600 Rockville Pike, Bethesda, MD 20894, USA.
authors.forename: Lianyi
authors.initials: L
authors.lastname: Han
authors.affiliation: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bldg. 38 A, Room 8N805, 8600 Rockville Pike, Bethesda, MD 20894, USA.
authors.forename: Jane
authors.initials: J
authors.lastname: He
authors.affiliation: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bldg. 38 A, Room 8N805, 8600 Rockville Pike, Bethesda, MD 20894, USA.
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Lanczycki
authors.affiliation: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bldg. 38 A, Room 8N805, 8600 Rockville Pike, Bethesda, MD 20894, USA.
authors.forename: Shennan
authors.initials: S
authors.lastname: Lu
authors.affiliation: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bldg. 38 A, Room 8N805, 8600 Rockville Pike, Bethesda, MD 20894, USA.
authors.forename: Farideh
authors.initials: F
authors.lastname: Chitsaz
authors.affiliation: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bldg. 38 A, Room 8N805, 8600 Rockville Pike, Bethesda, MD 20894, USA.
authors.forename: Myra K
authors.initials: MK
authors.lastname: Derbyshire
authors.affiliation: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bldg. 38 A, Room 8N805, 8600 Rockville Pike, Bethesda, MD 20894, USA.
authors.forename: Renata C
authors.initials: RC
authors.lastname: Geer
authors.affiliation: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bldg. 38 A, Room 8N805, 8600 Rockville Pike, Bethesda, MD 20894, USA.
authors.forename: Noreen R
authors.initials: NR
authors.lastname: Gonzales
authors.affiliation: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bldg. 38 A, Room 8N805, 8600 Rockville Pike, Bethesda, MD 20894, USA.
authors.forename: Marc
authors.initials: M
authors.lastname: Gwadz
authors.affiliation: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bldg. 38 A, Room 8N805, 8600 Rockville Pike, Bethesda, MD 20894, USA.
authors.forename: David I
authors.initials: DI
authors.lastname: Hurwitz
authors.affiliation: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bldg. 38 A, Room 8N805, 8600 Rockville Pike, Bethesda, MD 20894, USA.
authors.forename: Fu
authors.initials: F
authors.lastname: Lu
authors.affiliation: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bldg. 38 A, Room 8N805, 8600 Rockville Pike, Bethesda, MD 20894, USA.
authors.forename: Gabriele H
authors.initials: GH
authors.lastname: Marchler
authors.affiliation: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bldg. 38 A, Room 8N805, 8600 Rockville Pike, Bethesda, MD 20894, USA.
authors.forename: James S
authors.initials: JS
authors.lastname: Song
authors.affiliation: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bldg. 38 A, Room 8N805, 8600 Rockville Pike, Bethesda, MD 20894, USA.
authors.forename: Narmada
authors.initials: N
authors.lastname: Thanki
authors.affiliation: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bldg. 38 A, Room 8N805, 8600 Rockville Pike, Bethesda, MD 20894, USA.
authors.forename: Zhouxi
authors.initials: Z
authors.lastname: Wang
authors.affiliation: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bldg. 38 A, Room 8N805, 8600 Rockville Pike, Bethesda, MD 20894, USA.
authors.forename: Roxanne A
authors.initials: RA
authors.lastname: Yamashita
authors.affiliation: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bldg. 38 A, Room 8N805, 8600 Rockville Pike, Bethesda, MD 20894, USA.
authors.forename: Dachuan
authors.initials: D
authors.lastname: Zhang
authors.affiliation: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bldg. 38 A, Room 8N805, 8600 Rockville Pike, Bethesda, MD 20894, USA.
authors.forename: Chanjuan
authors.initials: C
authors.lastname: Zheng
authors.affiliation: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bldg. 38 A, Room 8N805, 8600 Rockville Pike, Bethesda, MD 20894, USA.
authors.forename: Lewis Y
authors.initials: LY
authors.lastname: Geer
authors.affiliation: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bldg. 38 A, Room 8N805, 8600 Rockville Pike, Bethesda, MD 20894, USA.
authors.forename: Stephen H
authors.initials: SH
authors.lastname: Bryant
mesh_terms: D019295:Computational Biology / Q000379:methods*; D030562:Databases, Protein; D033181:Information Dissemination; D020407:Internet; D054730:Protein Interaction Domains and Motifs; D011506:Proteins / Q000737:chemistry / Q000145:classification / Q000235:genetics
chemical_list: D011506:Proteins