title: Predictors of Pharmacological Therapy of Ectopic Atrial Tachycardia in Children.
abstract: Ectopic atrial tachycardia (EAT) is a relatively common type of supraventricular tachycardia in the pediatric population, and it can be resistant to antiarrhythmic drugs and lead to tachycardia-induced cardiomyopathy (TIC) if not properly managed. The purpose of this study was to determine the predictors of the response to pharmacological therapy in children with EAT. From January 2009 to April 2014, 115 children were admitted to our hospital with a diagnosis of EAT and placed on antiarrhythmic drugs. We examined the clinical history, response to therapy, and follow-up of the children. The incidence of TIC secondary to EAT was 22.6% (n = 26) in children. Incessant EAT accounted for 44.3% of all patients. Control of EAT with antiarrhythmic therapy was achieved in 73.9% (n = 85) of the children. The combination of sotalol and propafenone performed well in controlling EAT in children [complete control in 35 (49.3%) of 71]. The mean time of conversion to sinus rhythm was 24 days, and the mean duration of therapy was 11 months in children with resolution. Multivariate predictors of the control of EAT were age at presentation (OR 0.289, P = 0.038) and tachycardia type (OR 0.276, P = 0.006). TIC occurs in 22.6% of children with EAT. Incessant EAT is more frequently complicated by TIC. Independent factors associated with a good response to pharmacological therapy include a younger age at presentation and non-incessant tachycardia in children with EAT.
authors.affiliation: Department of Pediatric Cardiology, Heart Center, The First Hospital of Tsinghua University, Medical Center, Tsinghua University, Beijing, China.|Beijing Huaxin Hospital, Beijing, 100016, China.
authors.forename: Haiyan
authors.initials: H
authors.lastname: Ge
authors.affiliation: Department of Pediatric Cardiology, Heart Center, The First Hospital of Tsinghua University, Medical Center, Tsinghua University, Beijing, China. libmu_tsinghua@163.com.|Beijing Huaxin Hospital, Beijing, 100016, China. libmu_tsinghua@163.com.
authors.forename: Xiaomei
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Pediatric Cardiology, Heart Center, The First Hospital of Tsinghua University, Medical Center, Tsinghua University, Beijing, China.|Beijing Huaxin Hospital, Beijing, 100016, China.
authors.forename: Haiju
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Pediatric Cardiology, Heart Center, The First Hospital of Tsinghua University, Medical Center, Tsinghua University, Beijing, China.|Beijing Huaxin Hospital, Beijing, 100016, China.
authors.forename: He
authors.initials: H
authors.lastname: Jiang
mesh_terms: D000638:Amiodarone / Q000627:therapeutic use; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D009202:Cardiomyopathies / Q000453:epidemiology*; D002648:Child; D002675:Child, Preschool; D002681:China; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D016015:Logistic Models; D008297:Male; D008790:Metoprolol / Q000627:therapeutic use; D015999:Multivariate Analysis; D011405:Propafenone / Q000627:therapeutic use*; D012189:Retrospective Studies; D013015:Sotalol / Q000627:therapeutic use*; D013612:Tachycardia, Ectopic Atrial / Q000150:complications* / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D000889:Anti-Arrhythmia Agents; D011405:Propafenone; D013015:Sotalol; D008790:Metoprolol; D000638:Amiodarone
keywords: Antiarrhythmic drug; Atrial tachycardia; Pediatric; Sotalol; Tachycardia-induced cardiomyopathy