title: Benefit of Measuring Anterior Segment Structures Using an Increased Number of Optical Coherence Tomography Images: The Chinese American Eye Study.
abstract: The purpose of this study was to evaluate the benefit of analyzing an increased number of anterior segment optical coherence tomography (AS-OCT) images on measurement values of various anterior segment parameters.
  
  
  
  Subjects for this cross-sectional study were recruited from the Chinese American Eye Study (CHES), a population-based study in Los Angeles, CA. Thirty-two AS-OCT images were acquired from one eye each of 83 consecutive subjects. Sixteen parameters were analyzed in each image, including angle opening distance (AOD), angle recess area (ARA), trabecular iris space area (TISA), trabecular iris angle (TIA), scleral spur angle (SSAngle), lens vault (LV), pupillary diameter (PD), anterior chamber depth (ACD), anterior chamber width (ACW), iris area (IA), and anterior chamber area (ACA). Data from 1, 2, 4, 8, 16, or 32 OCT images were averaged across subjects to calculate the range and mean of measurement values for each parameter.
  
  
  
  Anatomical variations were poorly captured with fewer OCT images for AOD, ARA, TISA, SSAngle, IA, and LV. For these parameters, the range and mean of measurement values obtained from one OCT image deviated from 32-image values by up to 43.9% and 13.3% of the 32-image mean, respectively. These deviations decreased when additional OCT images were analyzed. Deviations from 32-image range and mean values were less pronounced regardless of image number for PD, ACD, ACW, and ACA, measuring up to 3.5% and 5.0%, respectively.
  
  
  
  A multi-image approach should be the standard in OCT-based studies of AOD, ARA, TISA, TIA, SSAngle, IA, and LV.
authors.affiliation: Roski Eye Institute, Keck School of Medicine at the University of Southern California Los Angeles, Los Angeles, California, United States.
authors.forename: Benjamin Y
authors.initials: BY
authors.lastname: Xu
authors.affiliation: Keck School of Medicine at the University of Southern California Los Angeles, Los Angeles, California, United States.
authors.forename: Paul
authors.initials: P
authors.lastname: Israelsen
authors.affiliation: Roski Eye Institute, Keck School of Medicine at the University of Southern California Los Angeles, Los Angeles, California, United States.
authors.forename: Billy X
authors.initials: BX
authors.lastname: Pan
authors.affiliation: Roski Eye Institute, Keck School of Medicine at the University of Southern California Los Angeles, Los Angeles, California, United States.
authors.forename: Dandan
authors.initials: D
authors.lastname: Wang
authors.affiliation: Roski Eye Institute, Keck School of Medicine at the University of Southern California Los Angeles, Los Angeles, California, United States.
authors.forename: Xuejuan
authors.initials: X
authors.lastname: Jiang
authors.affiliation: Roski Eye Institute, Keck School of Medicine at the University of Southern California Los Angeles, Los Angeles, California, United States.
authors.forename: Rohit
authors.initials: R
authors.lastname: Varma
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000869:Anterior Eye Segment / Q000000981:diagnostic imaging*; D001213:Asian; D002140:California / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005260:Female; D015812:Glaucoma, Angle-Closure / Q000175:diagnosis* / Q000208:ethnology / Q000503:physiopathology; D006068:Gonioscopy; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012372:ROC Curve; D015203:Reproducibility of Results; D041623:Tomography, Optical Coherence / Q000379:methods*