title: Accuracy of coronary computed tomography angiography for bioresorbable scaffold luminal investigation: a comparison with optical coherence tomography.
abstract: To establish the accuracy of coronary computed tomography angiography (CTA) for in-scaffold quantitative evaluation with optical coherence tomography (OCT) as a reference. The translucent backbone of the bioresorbable scaffold allow us to evaluate non-invasively the coronary lumen with coronary CTA. In the ABSORB first-in-man studies, coronary CTA was shown to be feasible for quantitative luminal assessment. Nevertheless, a comparison with an intravascular modality with higher resolution has never been performed. In the ABSORB Cohort B trial, 101 patient with non-complex lesions were treated with the fully biodegradable vascular scaffold. For this analysis, all patients who underwent coronary CTA at 18 months and OCT within ±180 days were included. Coronary CTA and OCT data were analysed at an independent core laboratory for quantitative cross-sectional luminal dimensions. The primary objective was the accuracy and precision of coronary CTA for in-scaffold minimal lumen area assessment, with OCT as a reference. Among the 101 patients of the ABSORB Cohort B trial, 35 underwent both OCT and coronary CTA. The feasibility of quantitative evaluation was 74%. In the scaffolded segment, coronary CTA underestimated minimal lumen area by 9.8% (accuracy 0.39 mm2, precision 1.0 mm2, 95% limits of agreement -1.71 to 2.50 mm2). A similar level of agreement was observed in the non-scaffolded segment. Compared to OCT, coronary CTA appears to be accurate for the estimation of in-scaffold luminal areas, with no difference compared to the non-scaffolded region.
authors.affiliation: Cardiology Department, Academic Medical Centre, Amsterdam, The Netherlands.
authors.forename: Carlos
authors.initials: C
authors.lastname: Collet
authors.affiliation: Cardiology Department, Academic Medical Centre, Amsterdam, The Netherlands.
authors.forename: Yohei
authors.initials: Y
authors.lastname: Sotomi
authors.affiliation: ThoraxCenter, Erasmus University Medical Centre, Rotterdam, The Netherlands.
authors.forename: Rafael
authors.initials: R
authors.lastname: Cavalcante
authors.affiliation: Cardiology Department, Academic Medical Centre, Amsterdam, The Netherlands.
authors.forename: Taku
authors.initials: T
authors.lastname: Asano
authors.affiliation: ThoraxCenter, Erasmus University Medical Centre, Rotterdam, The Netherlands.
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Miyazaki
authors.affiliation: ThoraxCenter, Erasmus University Medical Centre, Rotterdam, The Netherlands.
authors.forename: Erhan
authors.initials: E
authors.lastname: Tenekecioglu
authors.affiliation: Division of Image Processing, Department of Radiology, Leiden University, Leiden, The Netherlands.|Medis medical imaging systems BV, Leiden, The Netherlands.
authors.forename: Pieter
authors.initials: P
authors.lastname: Kistlaar
authors.affiliation: ThoraxCenter, Erasmus University Medical Centre, Rotterdam, The Netherlands.
authors.forename: Yaping
authors.initials: Y
authors.lastname: Zeng
authors.affiliation: Northern Region Heart Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
authors.forename: Pannipa
authors.initials: P
authors.lastname: Suwanasson
authors.affiliation: Cardiology Department, Academic Medical Centre, Amsterdam, The Netherlands.
authors.forename: Robbert J
authors.initials: RJ
authors.lastname: de Winter
authors.affiliation: ThoraxCenter, Erasmus University Medical Centre, Rotterdam, The Netherlands.
authors.forename: Koen
authors.initials: K
authors.lastname: Nieman
authors.affiliation: Imperial College of London, London, UK. patrick.w.j.c.serruys@pwserruys.com.
authors.forename: Patrick W
authors.initials: PW
authors.lastname: Serruys
authors.affiliation: ThoraxCenter, Erasmus University Medical Centre, Rotterdam, The Netherlands.|Cardialysis BV, Rotterdam, The Netherlands.
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Onuma
mesh_terms: D020341:Absorbable Implants; D000368:Aged; D000072226:Computed Tomography Angiography; D017023:Coronary Angiography / Q000379:methods*; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000628:therapy*; D003331:Coronary Vessels / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects / Q000295:instrumentation*; D011237:Predictive Value of Tests; D011474:Prosthesis Design; D015203:Reproducibility of Results; D013997:Time Factors; D041623:Tomography, Optical Coherence; D016896:Treatment Outcome
keywords: Coronary computed tomography angiography; Optical coherence tomography; Polymeric scaffolds