title: Atopic Dermatitis According to GARP: New Mechanistic Insights in Disease Pathogenesis.
abstract: In complex disease such as atopic dermatitis, the journey from identification of strong risk loci to profound functional and mechanistic insights can take several years. Here, Manz et al. have elegantly deciphered the mechanistic pathways in the well-established 11q13.5 atopic dermatitis risk locus. Their genetic and functional insights emphasize a role for T regulatory cells in atopic dermatitis pathogenesis.
authors.affiliation: Department of Clinical Medicine, Trinity College, Dublin, Ireland; National Children's Research Centre, Our Lady's Children's Hospital Crumlin, Dublin, Ireland.
authors.forename: Janna
authors.initials: J
authors.lastname: Nousbeck
authors.affiliation: Department of Clinical Medicine, Trinity College, Dublin, Ireland; National Children's Research Centre, Our Lady's Children's Hospital Crumlin, Dublin, Ireland; Department of Paediatric Dermatology, Our Lady's Children's Hospital Crumlin, Dublin, Ireland. Electronic address: irvinea@tcd.ie.
authors.forename: Alan D
authors.initials: AD
authors.lastname: Irvine
mesh_terms: D003876:Dermatitis, Atopic / Q000235:genetics* / Q000503:physiopathology*; D018450:Disease Progression; D005260:Female; D005786:Gene Expression Regulation; D020022:Genetic Predisposition to Disease / Q000453:epidemiology*; D014644:Genetic Variation; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D011379:Prognosis; D012720:Severity of Illness Index
chemical_list: C087215:LRRC32 protein, human; D008565:Membrane Proteins