title: Backbone-Degradable Polymers Prepared by Chemical Vapor Deposition.
abstract: Polymers prepared by chemical vapor deposition (CVD) polymerization have found broad acceptance in research and industrial applications. However, their intrinsic lack of degradability has limited wider applicability in many areas, such as biomedical devices or regenerative medicine. Herein, we demonstrate, for the first time, a backbone-degradable polymer directly synthesized via CVD. The CVD co-polymerization of [2.2]para-cyclophanes with cyclic ketene acetals, specifically 5,6-benzo-2-methylene-1,3-dioxepane (BMDO), results in well-defined, hydrolytically degradable polymers, as confirmed by FTIR spectroscopy and ellipsometry. The degradation kinetics are dependent on the ratio of ketene acetals to [2.2]para-cyclophanes as well as the hydrophobicity of the films. These coatings address an unmet need in the biomedical polymer field, as they provide access to a wide range of reactive polymer coatings that combine interfacial multifunctionality with degradability.
authors.affiliation: Biointerfaces Institute and Departments of Biomedical Engineering and Chemical Engineering, University of Michigan, 2800 Plymouth Road, Ann Arbor, MI, 48109, USA.|Department of Applied Chemistry, School of Science, Northwestern Polytechnical University, Xi'an, 710072, China.
authors.forename: Fan
authors.initials: F
authors.lastname: Xie
authors.affiliation: Biointerfaces Institute and Departments of Biomedical Engineering and Chemical Engineering, University of Michigan, 2800 Plymouth Road, Ann Arbor, MI, 48109, USA.
authors.forename: Xiaopei
authors.initials: X
authors.lastname: Deng
authors.affiliation: Institute of Functional Interfaces, Karlsruhe Institute of Technology (KIT), Hermann-von-Helmholtz-Platz 1, 76344, Eggenstein-Leopoldsshafen, Germany.
authors.forename: Domenic
authors.initials: D
authors.lastname: Kratzer
authors.affiliation: Biointerfaces Institute and Departments of Biomedical Engineering and Chemical Engineering, University of Michigan, 2800 Plymouth Road, Ann Arbor, MI, 48109, USA.
authors.forename: Kenneth C K
authors.initials: KC
authors.lastname: Cheng
authors.affiliation: Institute of Functional Interfaces, Karlsruhe Institute of Technology (KIT), Hermann-von-Helmholtz-Platz 1, 76344, Eggenstein-Leopoldsshafen, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Friedmann
authors.affiliation: Department of Applied Chemistry, School of Science, Northwestern Polytechnical University, Xi'an, 710072, China.
authors.forename: Shuhua
authors.initials: S
authors.lastname: Qi
authors.affiliation: Biointerfaces Institute and Departments of Biomedical Engineering and Chemical Engineering, University of Michigan, 2800 Plymouth Road, Ann Arbor, MI, 48109, USA.
authors.forename: Luis
authors.initials: L
authors.lastname: Solorio
authors.affiliation: Biointerfaces Institute and Departments of Biomedical Engineering and Chemical Engineering, University of Michigan, 2800 Plymouth Road, Ann Arbor, MI, 48109, USA.|Institute of Functional Interfaces, Karlsruhe Institute of Technology (KIT), Hermann-von-Helmholtz-Platz 1, 76344, Eggenstein-Leopoldsshafen, Germany.
authors.forename: Joerg
authors.initials: J
authors.lastname: Lahann
mesh_terms: D000080:Acetals / Q000138:chemical synthesis / Q000737:chemistry*; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry; D060326:Chemistry Techniques, Synthetic / Q000379:methods*; D003500:Cyclization; D004988:Ethers, Cyclic / Q000138:chemical synthesis / Q000737:chemistry*; D005030:Ethylenes / Q000138:chemical synthesis / Q000737:chemistry*; D007659:Ketones / Q000138:chemical synthesis / Q000737:chemistry*; D010082:Oxepins / Q000138:chemical synthesis / Q000737:chemistry; D010880:Piperidines / Q000138:chemical synthesis / Q000737:chemistry*; D058105:Polymerization; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*; D014835:Volatilization; D000097566:Cyclophanes
chemical_list: D000080:Acetals; D001672:Biocompatible Materials; D004988:Ethers, Cyclic; D005030:Ethylenes; D007659:Ketones; D010082:Oxepins; D010880:Piperidines; D011108:Polymers; C000605740:2-methylene-1,3-dioxepane; C121240:cyclophane 2; D000097566:Cyclophanes; C008223:ketene
keywords: CVD polymerization; cyclic ketene acetals; free-radical ring-opening polymerization; functional polymers; hydrolytic degradation