title: Prostate cancer characteristics in the World Trade Center cohort, 2002-2013.
abstract: An increased incidence of prostate cancer was reported in three cohorts of World Trade Center (WTC) respondents. It is uncertain whether this increase is because of WTC-related exposures or enhanced surveillance. Prostate cancer cases (2002-2013) were obtained from the WTC Health Program. Age, race, and Gleason score distribution were compared with New York State Cancer Registry cases from the same time period. Multivariate models were adjusted for age and race. Analyses of clinical characteristics of prostate cancer cases within the cohort were also carried out, adjusting for age, race, and WTC exposure categories. WTC respondents had a prostate cancer age-standardized rate ratio of 1.65 [95% confidence interval (CI): 1.37-1.93] compared with New York State; age-specific ratios were highest for ages 30-49 (2.28; 95% CI: 1.51-3.43), 70-74 (2.05; 95% CI: 1.03-4.10), and 80-84 years (5.65; 95% CI: 1.41-22.58). High WTC exposure was associated with advanced clinical stage (5.58; 95% CI: 1.05-29.76; Ptrend=0.03). WTC respondents continue to have a higher prostate cancer rate compared with New York State as a whole. Respondents with a higher WTC exposure level may have had more advanced clinical stage of prostate cancer.
authors.affiliation: Department of Preventive Medicine.
authors.forename: Dana
authors.initials: D
authors.lastname: Hashim
authors.affiliation: Tisch Cancer Institute.|Division of Hematology and Medical Oncology.
authors.forename: Paolo
authors.initials: P
authors.lastname: Boffetta
authors.affiliation: Tisch Cancer Institute.|Division of Hematology and Medical Oncology.
authors.forename: Matthew
authors.initials: M
authors.lastname: Galsky
authors.affiliation: Tisch Cancer Institute.|Division of Hematology and Medical Oncology.
authors.forename: William
authors.initials: W
authors.lastname: Oh
authors.affiliation: Department of Preventive Medicine.|Division of Occupational Medicine, University of Brescia, Brescia, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Lucchini
authors.affiliation: Department of Preventive Medicine.
authors.forename: Michael
authors.initials: M
authors.lastname: Crane
authors.affiliation: Department of Medicine, State University of New York at Stony Brook, Stony Brook.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Luft
authors.affiliation: Department of Occupational Medicine, Epidemiology and Prevention, Hofstra North Shore-LIJ School of Medicine, Great Neck, New York.
authors.forename: Jaqueline
authors.initials: J
authors.lastname: Moline
authors.affiliation: Department of Environmental and Occupational Medicine, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey, USA.
authors.forename: Iris
authors.initials: I
authors.lastname: Udasin
authors.affiliation: Department of Medicine, New York University School of Medicine, Bellevue Hospital Center, New York.
authors.forename: Denise
authors.initials: D
authors.lastname: Harrison
authors.affiliation: Institute for Translational Epidemiology.|Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai.
authors.forename: Emanuela
authors.initials: E
authors.lastname: Taioli
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D015331:Cohort Studies; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009518:New York / Q000453:epidemiology; D016273:Occupational Exposure / Q000009:adverse effects*; D011379:Prognosis; D011471:Prostatic Neoplasms / Q000453:epidemiology / Q000209:etiology*