title: Spontaneous Assembly of an Organic-Inorganic Nucleic Acid Z-DNA Double-Helix Structure.
abstract: Herein, we report a hybrid polyoxometalate organic-inorganic compound, Na2[(HGMP)2Mo5O15]⋅7 H2O (1; where GMP=guanosine monophosphate), which spontaneously assembles into a structure with dimensions that are strikingly similar to those of the naturally occurring left-handed Z-form of DNA. The helical parameters in the crystal structure of the new compound, such as rise per turn and helical twist per dimer, are nearly identical to this DNA conformation, allowing a close comparison of the two structures. Solution circular dichroism studies show that compound 1 also forms extended secondary structures in solution. Gel electrophoresis studies demonstrate the formation of non-covalent adducts with natural plasmids. Thus we show a route by which simple hybrid inorganic-organic monomers, such as compound 1, can spontaneously assemble into a double helix without the need for a covalently connected linear sequence of nucleic acid base pairs.
authors.affiliation: The University of Glasgow, WestChem, School of Chemistry, Joseph Black Building, Glasgow, G12 8QQ, UK.
authors.forename: Vladislav
authors.initials: V
authors.lastname: Kulikov
authors.affiliation: The University of Glasgow, WestChem, School of Chemistry, Joseph Black Building, Glasgow, G12 8QQ, UK.
authors.forename: Naomi A B
authors.initials: NA
authors.lastname: Johnson
authors.affiliation: The University of Glasgow, WestChem, School of Chemistry, Joseph Black Building, Glasgow, G12 8QQ, UK.
authors.forename: Andrew J
authors.identifier: 0000-0002-2042-7373
authors.initials: AJ
authors.lastname: Surman
authors.affiliation: The University of Glasgow, WestChem, School of Chemistry, Joseph Black Building, Glasgow, G12 8QQ, UK.
authors.forename: Marie
authors.initials: M
authors.lastname: Hutin
authors.affiliation: The University of Glasgow, Institute of Molecular Cell and Systems Biology, Joseph Black Building, Glasgow, G12 8QQ, UK.
authors.forename: Sharon M
authors.initials: SM
authors.lastname: Kelly
authors.affiliation: The University of Glasgow, WestChem, School of Chemistry, Joseph Black Building, Glasgow, G12 8QQ, UK.
authors.forename: Mohammed
authors.initials: M
authors.lastname: Hezwani
authors.affiliation: The University of Glasgow, WestChem, School of Chemistry, Joseph Black Building, Glasgow, G12 8QQ, UK.
authors.forename: De-Liang
authors.identifier: 0000-0003-3241-2379
authors.initials: DL
authors.lastname: Long
authors.affiliation: Universität zu Köln, Institut für Anorganische Chemie, Greinstrasse 6, 50939, Köln, Germany.|Iowa State University, Department of Chemistry, Ames, Iowa, 50011, USA.
authors.forename: Gerd
authors.initials: G
authors.lastname: Meyer
authors.affiliation: The University of Glasgow, WestChem, School of Chemistry, Joseph Black Building, Glasgow, G12 8QQ, UK.
authors.forename: Leroy
authors.identifier: 0000-0001-8035-5757
authors.initials: L
authors.lastname: Cronin
mesh_terms: D043542:DNA, Z-Form / Q000737:chemistry*; D008958:Models, Molecular; D008982:Molybdenum / Q000737:chemistry; D009690:Nucleic Acid Conformation; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D010100:Oxygen / Q000737:chemistry; D012964:Sodium / Q000737:chemistry; D017973:Tungsten Compounds / Q000737:chemistry; D000099294:Polyoxometalates
chemical_list: D043542:DNA, Z-Form; D008982:Molybdenum; D009942:Organometallic Compounds; D010100:Oxygen; D012964:Sodium; D017973:Tungsten Compounds; C102296:polyoxometalate I; D000099294:Polyoxometalates
keywords: evolution of evolution; helical structures; nucleobases; polyoxometalate hybrids; self-assembly