title: Survival Estimates and Mortality Risk Factors in a Cohort of HIV Vertically Infected Individuals in Salvador, Brazil.
abstract: There are few data on long-term survival of Brazilian children with vertically acquired HIV infection. We assessed survival, mortality risk factors and response to antiretroviral therapy (ART). We compared children with early and late access to care.
  
  
  
  We used Kaplan-Meier survival curves with Log-rank tests to compare survival time and mortality rates of 245 HIV vertically infected children admitted for care during 2002-2014.
  
  
  
  Total follow-up sum was 1584.4 person-years. Overall survival was 83.9%. Median age at start of ART was 51.6 (18.0-94.2) months, and median age at death was 8.2 (1.7-10.1) years (mortality rate: 1.7/100 person-years). Pneumonia and sepsis were the main causes of death. Male gender, viral load (VL) ≥100,000 copies, severe immunosuppression, moderate/severe symptoms and history of opportunistic infection were associated with higher mortality in bivariate analysis. Only severe symptoms remained associated in multivariate analysis (P = 0.03). There was no difference in mortality in early compared to late access group. Overall, 217 patients received ART; 192 had a recent VL, of which 116 (59.8%) had ≤400 copies. Variables associated with therapeutic failure were as follows: VL ≥100,000 copies, less immune suppression, age <12 months at admission and age <3 years at ART start.
  
  
  
  We have a high mortality rate in comparison with developed countries. Although early access did not impact mortality, we detected a trend in favor of early treatment as a protecting factor against mortality. We need to increase adherence to care and treatment, and better drugs to optimize outcomes.
authors.affiliation: From the *Federal University of Bahia, †Laboratório de Pesquisa em Infectologia, ‡Specialized Center for Diagnosis, Assistance and Research (CEDAP), and §School of Medicine, Department of Medicine, Federal University of Bahia, Salvador, Bahia, Brazil.
authors.forename: Cynthia R S
authors.initials: CR
authors.lastname: Lorenzo
authors.forename: Eduardo M
authors.initials: EM
authors.lastname: Netto
authors.forename: Fátima R L
authors.initials: FR
authors.lastname: Patrício
authors.forename: Carlos
authors.initials: C
authors.lastname: Brites
mesh_terms: D001938:Brazil / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D015658:HIV Infections / Q000453:epidemiology* / Q000635:transmission; D006801:Humans; D007223:Infant; D018445:Infectious Disease Transmission, Vertical; D053208:Kaplan-Meier Estimate; D012189:Retrospective Studies; D012307:Risk Factors