title: Total Recall: Can We Reshape T Cell Memory by Lymphoablation?
abstract: Despite recent advances in immunosuppression, donor-reactive memory T cells remain a serious threat to successful organ transplantation. To alleviate damaging effects of preexisting immunologic memory, lymphoablative induction therapies are used as part of standard care in sensitized recipients. However, accumulating evidence suggests that memory T cells have advantages over their naive counterparts in surviving depletion and expanding under lymphopenic conditions. This may at least partially explain the inability of existing lymphoablative strategies to improve long-term allograft outcome in sensitized recipients, despite the well-documented decrease in the frequency of early acute rejection episodes. This minireview summarizes the insights gained from both experimental and clinical transplantation as to the effects of existing lymphoablative strategies on memory T cells and discusses the latest research developments aimed at improving the efficacy and safety of lymphoablation.
authors.affiliation: Glickman Urological Institute and Department of Immunology, Cleveland Clinic, Cleveland, OH.
authors.forename: M
authors.initials: M
authors.lastname: Nicosia
authors.affiliation: Glickman Urological Institute and Department of Immunology, Cleveland Clinic, Cleveland, OH.
authors.forename: A
authors.initials: A
authors.lastname: Valujskikh
mesh_terms: D006084:Graft Rejection / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D007156:Immunologic Memory / Q000276:immunology*; D008212:Lymphocyte Depletion; D016377:Organ Transplantation / Q000009:adverse effects*; D023001:Transplantation Tolerance / Q000276:immunology*
keywords: T cell biology; basic (laboratory) research/science; cellular biology; fusion proteins and monoclonal antibodies; immunobiology; immunosuppressant; immunosuppression/immune modulation; lymphocyte biology; translational research/science