title: [Mechanotransduction and mechanical control of gene expression.]
abstract: Cells change gene expression when they differentiate into different cell lineages. Cells also change their gene expression profiles to adapt to altering milieus. Even physical forces(for example, forces evoked by muscle contraction or exercise)change gene expression dramatically, although the molecular mechanisms of this physico-genetic link are largely unknown. Here, we summarize several works published recently, trying to highlight the physical force as an essential parameter of gene expression and maintenance of homeostasis.
authors.affiliation: Department of Developmental Neurobiology, Institute of Development, Aging and Cancer, Tohoku University, Japan.
authors.forename: Kota
authors.initials: K
authors.lastname: Miyasaka
authors.affiliation: Department of Developmental Neurobiology, Institute of Development, Aging and Cancer, Tohoku University, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kubo
authors.affiliation: Department of Developmental Neurobiology, Institute of Development, Aging and Cancer, Tohoku University, Japan.
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Ogura
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D015870:Gene Expression; D006706:Homeostasis; D006801:Humans; D040542:Mechanotransduction, Cellular; D018482:Muscle, Skeletal / Q000378:metabolism