title: Radiological imaging features of glioblastoma with oligodendroglioma component: a comparison with conventional glioblastoma.
abstract: BACKGROUND
  Glioblastoma with oligodendroglioma component (GBMO) is a subtype of conventional glioblastoma (cGBM), which is categorized as WHO grade IV. GBMO can be histopathologically distinguished from cGBM and the prognosis of GBMO is better than that of cGBM. However, no systematic review of GBMO imaging findings has been published to date.
  
  
  OBJECTIVE
  To clarify the radiological imaging features of GBMO compared with those of cGBM.
  
  
  METHODS
  The participants were 15 patients with GBMO and 32 patients with cGBM as a control group, all of whom were histopathologically diagnosed. A radiologist retrospectively reviewed the imaging findings of both computed tomography (CT) and magnetic resonance imaging (MRI) for density, signal intensity, contrast medium enhancement (CE), cortical swelling, and cortical swelling without CE. We statistically analyzed the imaging findings by Chi-squared test.
  
  
  RESULTS
  Cortical swelling without CE in GBMO was significantly greater than that in cGBM (P= 0.004). Non-CE and heterogeneous solid enhancement were observed significantly more often in GBMO (P= 0.004). No other findings were significant.
  
  
  CONCLUSIONS
  There was significant difference in the findings of the CE, which exhibited solid heterogeneous enhancement in GBMO. Cortical swelling without CE can be considered significantly characteristic of GBMO.
authors.affiliation: Department of Diagnostic Radiology, Yamagata University Faculty of Medicine, Yamagata, Japan.
authors.forename: Masafumi
authors.initials: M
authors.lastname: Kanoto
authors.affiliation: Department of Diagnostic Radiology, Yamagata University Faculty of Medicine, Yamagata, Japan.
authors.forename: Kazukuni
authors.initials: K
authors.lastname: Kirii
authors.affiliation: Department of Diagnostic Radiology, Yamagata University Faculty of Medicine, Yamagata, Japan.
authors.forename: Yuuki
authors.initials: Y
authors.lastname: Toyoguchi
authors.affiliation: Department of Radiology, Saga University Faculty of Medicine, Saga, Japan.
authors.forename: Masashi
authors.initials: M
authors.lastname: Nishihara
authors.affiliation: Department of Radiology, Nagoya City University Graduate School of Medical Sciences, Nagoya City, Japan.
authors.forename: Keita
authors.initials: K
authors.lastname: Sakurai
authors.affiliation: Department of Radiology, Fujita Health University, Fujita, Japan.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Murayama
authors.affiliation: Department of Radiology, National Center for Global Health and Medicine, Japan.
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Noguchi
authors.affiliation: Department of Neurosurgery, Yamagata University Faculty of Medicine, Yamagata, Japan.
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Matsuda
authors.affiliation: Department of Neurosurgery, Yamagata University Faculty of Medicine, Yamagata, Japan.
authors.forename: Kaori
authors.initials: K
authors.lastname: Sakurada
authors.affiliation: Department of Neurosurgery, Yamagata University Faculty of Medicine, Yamagata, Japan.
authors.forename: Yukihiko
authors.initials: Y
authors.lastname: Sonoda
authors.affiliation: Department of Diagnostic Radiology, Yamagata University Faculty of Medicine, Yamagata, Japan.
authors.forename: Takaaki
authors.initials: T
authors.lastname: Hosoya
keywords: Glioblastoma; computed tomography (CT); glioblastoma with oligodendroglioma component; magnetic resonance imaging (MRI); oligodendroglioma