title: [The relationship of molecular genetic markers with clinical signs and risk factors of periodontitis].
abstract: The study revealed positive correlation between bleeding on probing and teeth loss risk with periodontal hypercolonization by Porphyromonas gingivalis, Prevotella intermedia and Treponema denticola. Pathological tooth mobility was associated with hypercolonization by P. intermedia and Tannerella forsythensis. Expression of IL8, TNF-α, MMP8 and MMP9 genes was also assessed in patient groups divided according to the depth of periodontal pockets and-the severity of chronic periodontitis revealing IL8 as positive diagnostic marker.
authors.affiliation: Sechenov First Moscow State Medical University, Moscow, Russia; Central Research Institute of Dentistry and Maxillofacial Surgery of Ministry of Health of Russian Federation, Moscow, Russia.
authors.forename: O A
authors.initials: OA
authors.lastname: Zorina
authors.affiliation: Sechenov First Moscow State Medical University, Moscow, Russia.
authors.forename: N K
authors.initials: NK
authors.lastname: Aimadinova
authors.affiliation: Sechenov First Moscow State Medical University, Moscow, Russia.
authors.forename: A A
authors.initials: AA
authors.lastname: Basova
authors.affiliation: Pirogov Russian National Research Medical University, Moscow, Russia.
authors.forename: D V
authors.initials: DV
authors.lastname: Rebrikov
mesh_terms: D000328:Adult; D002908:Chronic Disease; D005260:Female; D005819:Genetic Markers; D006470:Hemorrhage / Q000209:etiology / Q000235:genetics; D006801:Humans; D016209:Interleukin-8 / Q000235:genetics; D008297:Male; D020784:Matrix Metalloproteinase 8 / Q000235:genetics; D020780:Matrix Metalloproteinase 9 / Q000235:genetics; D008875:Middle Aged; D010514:Periodontal Pocket / Q000209:etiology / Q000235:genetics; D010518:Periodontitis / Q000150:complications / Q000175:diagnosis* / Q000235:genetics* / Q000382:microbiology; D016966:Porphyromonas gingivalis / Q000302:isolation & purification; D018713:Prevotella intermedia / Q000302:isolation & purification; D012307:Risk Factors; D016388:Tooth Loss / Q000209:etiology / Q000235:genetics; D014086:Tooth Mobility / Q000209:etiology / Q000235:genetics; D059467:Transcriptome; D048373:Treponema denticola / Q000302:isolation & purification; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics; D055815:Young Adult
chemical_list: D005819:Genetic Markers; D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha; D020784:Matrix Metalloproteinase 8; D020780:Matrix Metalloproteinase 9