title: Pseudopeptidic compounds for the generation of dynamic combinatorial libraries of chemically diverse macrocycles in aqueous media.
abstract: A straightforward four-step synthesis leads to the preparation of C2-symmetric dithiols containing a central aromatic core and amino acid side chains. These building blocks allow the preparation of dynamic covalent libraries of pseudopeptidic macrocycles in aqueous media that cover a broad range of polarities, functional groups and bulkiness mirroring the diversity found in natural peptides. The versatility of the generated dynamic libraries has been illustrated by the amplification of two different members from the same library upon the action of two biologically relevant templates.
authors.affiliation: Department of Biological Chemistry and Molecular Modelling, IQAC-CSIC, Jordi Girona, 18-26, 08034, Barcelona, Spain. jordi.sola@iqac.csic.es ignacio.alfonso@iqac.csic.es.
authors.forename: Joan
authors.initials: J
authors.lastname: Atcher
authors.affiliation: Department of Biological Chemistry and Molecular Modelling, IQAC-CSIC, Jordi Girona, 18-26, 08034, Barcelona, Spain. jordi.sola@iqac.csic.es ignacio.alfonso@iqac.csic.es.
authors.forename: Jordi
authors.identifier: http://orcid.org/0000-0002-3389-3429
authors.initials: J
authors.lastname: Solà
authors.affiliation: Department of Biological Chemistry and Molecular Modelling, IQAC-CSIC, Jordi Girona, 18-26, 08034, Barcelona, Spain. jordi.sola@iqac.csic.es ignacio.alfonso@iqac.csic.es.
authors.forename: Ignacio
authors.identifier: http://orcid.org/0000-0003-0678-0362
authors.initials: I
authors.lastname: Alfonso
mesh_terms: D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques; D047028:Macrocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D010084:Oxidation-Reduction; D057786:Peptidomimetics / Q000138:chemical synthesis* / Q000737:chemistry; D013438:Sulfhydryl Compounds / Q000138:chemical synthesis / Q000737:chemistry; D014867:Water / Q000737:chemistry
chemical_list: D000596:Amino Acids; D047028:Macrocyclic Compounds; D057786:Peptidomimetics; D013438:Sulfhydryl Compounds; D014867:Water