title: Development and validation of a patient-reported outcome measure in vitiligo: The Self Assessment Vitiligo Extent Score (SA-VES).
abstract: BACKGROUND
  The Vitiligo Extent Score (VES) has recently been introduced as a physicians' score for the clinical assessment of the extent of vitiligo, but a good patient self-assessment score is lacking.
  
  
  OBJECTIVE
  The objective is to develop and validate a simplified version of the VES as a patient-reported outcome measure (PROM).
  
  
  METHODS
  After extensive pilot testing, patients were asked to score their vitiligo extent twice with an interval of 2 weeks using the Self Assessment Vitiligo Extent Score (SA-VES). The scores were compared with the physicians' evaluation (VES).
  
  
  RESULTS
  The SA-VES demonstrated very good test-retest reliability (intraclass correlation = 0.948, 95% confidence interval [CI]: 0.911-0.970) that was not affected by age, skin type, or vitiligo distribution pattern. According to patients, this evaluation method was easy to use (22% very easy; 49% easy; 29% normal) and required <5 minutes in the majority of patients (73%, <5 minutes; 24%, 5-10 minutes; 2%, 10-15 minutes). Comparison of the SA-VES and the VES demonstrated excellent correlation (r = 0.986, P <.001).
  
  
  CONCLUSIONS
  Few patients had a dark skin type.
  
  
  CONCLUSIONS
  The results demonstrate excellent reliability of the SA-VES and excellent correlation with its investigator-reported counterpart (VES). This patient-oriented evaluation method provides a useful tool for the assessment of vitiligo extent.
authors.affiliation: Department of Dermatology, Ghent University Hospital, Ghent, France. Electronic address: Nanja.vangeel@UGent.be.
authors.forename: Nanja
authors.initials: N
authors.lastname: van Geel
authors.affiliation: Department of Dermatology, University of Amsterdam and Netherlands Institute for Pigment Disorders, Amsterdam, The Netherlands.
authors.forename: Janny E
authors.initials: JE
authors.lastname: Lommerts
authors.affiliation: Department of Dermatology, University of Amsterdam and Netherlands Institute for Pigment Disorders, Amsterdam, The Netherlands.
authors.forename: Marcel W
authors.initials: MW
authors.lastname: Bekkenk
authors.affiliation: VU University Medical Center, Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, Amsterdam, The Netherlands.
authors.forename: Cecilia A C
authors.initials: CA
authors.lastname: Prinsen
authors.affiliation: Centre of Evidence Based Dermatology, University of Nottingham, Nottingham, United Kingdom.
authors.forename: Viktoria
authors.initials: V
authors.lastname: Eleftheriadou
authors.affiliation: National Reference Center for Rare Skin Diseases, Hôpital St-André, University Hospital Center of Bordeaux, Bordeaux, France.
authors.forename: Alain
authors.initials: A
authors.lastname: Taieb
authors.affiliation: San Gallicano Dermatology Institute, Via Elio Chianesi, Roma, Italy.
authors.forename: Mauro
authors.initials: M
authors.lastname: Picardo
authors.affiliation: EA EpiDermE (Epidémiologie en Dermatologie et Evaluation des Thérapeutiques), UPE-Université Paris-Est, Service de Dermatologie, Hôpital Henri Mondor, Paris, France.
authors.forename: Khaled
authors.initials: K
authors.lastname: Ezzedine
authors.affiliation: Department of Dermatology, University of Amsterdam and Netherlands Institute for Pigment Disorders, Amsterdam, The Netherlands.
authors.forename: Albert
authors.initials: A
authors.lastname: Wolkerstorfer
authors.affiliation: Department of Dermatology, Ghent University Hospital, Ghent, France.
authors.forename: Reinhart
authors.initials: R
authors.lastname: Speeckaert
mesh_terms: D000293:Adolescent; D000328:Adult; D001830:Body Surface Area; D002648:Child; D059026:Diagnostic Self Evaluation; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000071066:Patient Reported Outcome Measures; D010865:Pilot Projects; D015203:Reproducibility of Results; D012720:Severity of Illness Index; D014820:Vitiligo / Q000473:pathology*; D055815:Young Adult
keywords: body surface area; outcome measurement; patient-reported outcomes; severity; vitiligo