title: Endovascular Treatment of Popliteal Artery Aneurysms: A Word of Caution after Long-Term Follow-up.
abstract: BACKGROUND
  The aim of this work was to evaluate the long-term patency of endografting in the treatment of popliteal artery aneurysms (PAAs) and to identify which factors may be predictors of graft occlusion.
  
  
  METHODS
  All the patients who underwent endovascular repair of PAA were analyzed from 2006 until 2014 on the basis of symptoms, comorbidities, limb salvage, and long-term patency. The predictive value of the different variables was assessed in univariate analysis for primary patency and, for factors resulted significant, a multivariate analysis was performed. The Kaplan-Meier life table method was used to calculate patency and limb salvage.
  
  
  RESULTS
  We treated 65 PAAs in 57 patients (53 men and 4 women). PAAs were symptomatic in 26 cases (40%) and 34% were the emergency cases; the mean aneurysm size was 33.8 ± 17 mm. Mean follow-up was 35 months ± 25. Graft occlusion occurred in 22 limbs (35%). We had 9 amputations (14.5%). The late conversion to open surgery was 6.4%. The cumulative estimated 60-month primary patency, secondary patency, and limb salvage were respectively 57% (standard error [SE] ±0.7), 73% (SE ±0.7), and 83% (SE ±0.5). We found that diabetes (hazard ratio [HR] 2.936, 95% confidence interval [CI] 0.993-8.683), associated percutaneous transluminal angioplasty (PTA) procedures (HR 2.534, 95% CI 1.115-5.757), symptoms (HR 2.492, 95% CI 1.127-5.510), and runoff scores (HR 2.069, 95% CI 0.942-4.544) were the most important risk factors for long-term patency at univariate analysis. When considering a multivariate analysis symptoms (HR 2.066, 95% CI 0.862-4.952) become the principal risk factor followed by diabetes (HR 1.808, 95% CI 0.531-6.157)], runoff scores (HR 1.716, 95% CI 0.757-3.893) and associated PTA procedures (HR 1.441, 95% CI 0.519-3.839), but no one reached a statistical significance.
  
  
  CONCLUSIONS
  On the base of our experience it seems that several factors affect durability in PAA endovascular repair, especially the presence of acute symptoms, diabetes, and runoff. Therefore until further refined clinical studies, we believe that the actual role of this technique must be yet clarified.
authors.affiliation: Vascular Division, Cardiovascular Department, HPG23 Hospital, Bergamo, Italy. Electronic address: cmaraglino@asst-pg23.it.
authors.forename: Cosimo
authors.initials: C
authors.lastname: Maraglino
authors.affiliation: Vascular Division, Cardiovascular Department, HPG23 Hospital, Bergamo, Italy.
authors.forename: Gianluca
authors.initials: G
authors.lastname: Canu
authors.affiliation: Vascular Division, Cardiovascular Department, HPG23 Hospital, Bergamo, Italy.
authors.forename: Renzo
authors.initials: R
authors.lastname: Ambrosi
authors.affiliation: Vascular Division, Cardiovascular Department, HPG23 Hospital, Bergamo, Italy.
authors.forename: Franco
authors.initials: F
authors.lastname: Briolini
authors.affiliation: Vascular Division, Cardiovascular Department, HPG23 Hospital, Bergamo, Italy.
authors.forename: Riccardo
authors.initials: R
authors.lastname: Gotti
authors.affiliation: Vascular Division, Cardiovascular Department, HPG23 Hospital, Bergamo, Italy.
authors.forename: Pietro
authors.initials: P
authors.lastname: Cefalì
authors.affiliation: Vascular Division, Cardiovascular Department, HPG23 Hospital, Bergamo, Italy.
authors.forename: Fabio
authors.initials: F
authors.lastname: Calliari
authors.affiliation: Cardiologic Division, Cardiovascular Department, HPG23 Hospital, Bergamo, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Ferrero
authors.affiliation: Vascular Division, Cardiovascular Department, HPG23 Hospital, Bergamo, Italy.
authors.forename: Franco
authors.initials: F
authors.lastname: Terraneo
mesh_terms: D000368:Aged; D000671:Amputation, Surgical; D000783:Aneurysm / Q000000981:diagnostic imaging / Q000401:mortality / Q000503:physiopathology / Q000601:surgery*; D000800:Angioplasty, Balloon / Q000009:adverse effects / Q000401:mortality; D019917:Blood Vessel Prosthesis Implantation / Q000009:adverse effects / Q000401:mortality; D000072226:Computed Tomography Angiography; D016208:Databases, Factual; D005260:Female; D006083:Graft Occlusion, Vascular / Q000209:etiology / Q000503:physiopathology; D006801:Humans; D053208:Kaplan-Meier Estimate; D023821:Limb Salvage; D008297:Male; D015999:Multivariate Analysis; D011150:Popliteal Artery / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery*; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome; D018615:Ultrasonography, Doppler, Color; D014654:Vascular Patency