title: Evaluation of interleukin-2, interleukin-8, and tumor necrosis factor-like weak inducer of apoptosis in hemodialysis and renal transplant patients and healthy controls.
abstract: There is an increasing evidence which suggests that cytokines have an important role in hemodialysis (HD) and renal transplant patients. The aim of this study was to evaluate the levels of interleukin (IL)-2, IL-8 and tumor necrosis factor-like weak inducer of apoptosis (TWEAK) in HD and renal transplant patients and healthy controls. A total of 152 individuals participated in this study over two years including 53 HD patients, 45 renal transplant patients, and 54 healthy controls. Serum levels of IL-2, IL-8 and TWEAK were measured by enzyme-linked immunosorbent assay. The mean ages for HD, renal transplant patients, and healthy controls were 51 ± 13.6, 41.1 ± 13.0 and 40.73 ± 7.0 years, respectively. Serum levels of IL-2, IL-8 and TWEAK were significantly higher in HD patients compared to healthy controls. IL-2 concentrations were significantly higher in renal transplant patients compared to healthy controls. In conclusion, the findings of this study showed high levels of IL-2, IL-8 and TWEAK in HD patients and normal levels of IL-8 and TWEAK but high levels of IL-2 in renal transplant patients.
authors.affiliation: Department of Allied Health Sciences, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Sultanate of Oman.
authors.forename: Nasar
authors.initials: N
authors.lastname: Alwahaibi
authors.affiliation: Department of Allied Health Sciences, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Sultanate of Oman.
authors.forename: Halima
authors.initials: H
authors.lastname: Alissaei
authors.affiliation: Department of Allied Health Sciences, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Sultanate of Oman.
authors.forename: Amal
authors.initials: A
authors.lastname: Al-Kalbani
authors.affiliation: Department of Pathology, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Sultanate of Oman.
authors.forename: Nadia
authors.initials: N
authors.lastname: Alabri
authors.affiliation: Department of Pathology, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Sultanate of Oman.
authors.forename: Zainab
authors.initials: Z
authors.lastname: Allawati
authors.affiliation: Department of Microbiology and Immunology, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Sultanate of Oman.
authors.forename: Mohammed
authors.initials: M
authors.lastname: Albalooshi
mesh_terms: D000328:Adult; D017209:Apoptosis; D006801:Humans; D007376:Interleukin-2; D015850:Interleukin-6; D016209:Interleukin-8; D016030:Kidney Transplantation; D008875:Middle Aged; D006435:Renal Dialysis
chemical_list: C508606:CXCL8 protein, human; C508594:IL2 protein, human; C508600:IL6 protein, human; D007376:Interleukin-2; D015850:Interleukin-6; D016209:Interleukin-8