title: Acquired Factor V Inhibitors in a Patient with End-stage Renal Disease.
abstract: We report a case of acquired factor V inhibitors (AFVIs) in a patient with end-stage renal disease receiving warfarin therapy for atrial fibrillation. A 72-year-old Japanese man was admitted to our hospital complaining of tarry stools and abdominal pain. The laboratory findings revealed eosinophilia (52.1%), prolonged activated partial thromboplastin time (APTT) (98 s), PT (84 s), a factor V (FV) activity of <3%, and an FV inhibitor level of 6 Bethesda units/mL. After administration of prednisolone was started, his coagulation findings improved. However, his renal failure progressed, and he ultimately required chronic hemodialysis. This is the first case of AFVIs in a patient starting hemodialysis for end-stage renal disease.
authors.affiliation: Nephrology, Dokkyo Medical University Koshigaya Hospital, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kitazawa
authors.forename: Hideo
authors.initials: H
authors.lastname: Misawa
authors.forename: Katsuhiro
authors.initials: K
authors.lastname: Nagahori
authors.forename: Ryo
authors.initials: R
authors.lastname: Koda
authors.forename: Atsunori
authors.initials: A
authors.lastname: Yoshino
authors.forename: Shinya
authors.initials: S
authors.lastname: Kawamoto
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Takeda
mesh_terms: D000368:Aged; D000925:Anticoagulants / Q000627:therapeutic use*; D001777:Blood Coagulation; D001780:Blood Coagulation Tests; D005165:Factor V / Q000037:antagonists & inhibitors*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000188:drug therapy*; D008297:Male; D010314:Partial Thromboplastin Time
chemical_list: D000925:Anticoagulants; D005165:Factor V