title: Massive lamotrigine poisoning. A case report.
abstract: Lamotrigine (LTG) represents the most commonly prescribed of the so-called new generation antiepileptic drugs. We describe a child who was admitted to the emergency room because of generalized tonic-clonic status epilepticus followed by a complex neurological picture with hyperkinesia and acute ataxia as a result of a LTG intoxication. The experience on acute LTG intoxication is very limited in pediatrics. The present case provides information on the clinical picture related to LTG overdose and confirms that drug intoxications should be considered in the differential diagnosis strategy when severe and polymorphic neurological symptoms occur acutely.
authors.affiliation: Clinical Pediatrics, Department of Pediatrics, University of Siena, Italy. Electronic address: salvatore.grosso@unisi.it.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Grosso
authors.affiliation: Clinical Pediatrics, Department of Pediatrics, University of Siena, Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Ferranti
authors.affiliation: Clinical Pediatrics, Department of Pediatrics, University of Siena, Italy.
authors.forename: Carla
authors.initials: C
authors.lastname: Gaggiano
authors.affiliation: Clinical Pediatrics, Department of Pediatrics, University of Siena, Italy.
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Grande
authors.affiliation: Clinical Pediatrics, Department of Pediatrics, University of Siena, Italy.
authors.forename: Barbara
authors.initials: B
authors.lastname: Loi
authors.affiliation: Clinical Pediatrics, Department of Pediatrics, University of Siena, Italy.
authors.forename: Rosanna
authors.initials: R
authors.lastname: Di Bartolo
mesh_terms: D000927:Anticonvulsants / Q000506:poisoning*; D002675:Child, Preschool; D003937:Diagnosis, Differential; D062787:Drug Overdose / Q000175:diagnosis*; D004409:Dyskinesia, Drug-Induced / Q000175:diagnosis; D004632:Emergency Medical Services; D006801:Humans; D000077213:Lamotrigine; D008297:Male; D013226:Status Epilepticus / Q000139:chemically induced / Q000175:diagnosis; D014227:Triazines / Q000506:poisoning*
chemical_list: D000927:Anticonvulsants; D014227:Triazines; D000077213:Lamotrigine
keywords: Acute ataxia; Adverse events; Antiepileptic drugs; Hyperkinesias; Status epilepticus