title: Exercise Attenuates High-Fat Diet-induced Disease Progression in 3xTg-AD Mice.
abstract: Little is known regarding the therapeutic role of exercise against the risk of a high-fat diet (HFD) for Alzheimer's disease (AD) and AD-like cognitive deficits. This study aimed to investigate the therapeutic effect of treadmill running against HFD-induced progression in AD neuropathology and cognitive impairments in the triple-transgenic AD (3xTg-AD) mice.
  
  
  
  The 3xTg-AD mice were assigned to a chow diet (control, n = 10), an HFD (n = 10), or an HFD combined with exercise (HFD + EX, n = 10) group. Mice in the HFD were fed with a 60% fat diet for 20 wk. The HFD + EX mice were additionally subjected to treadmill running.
  
  
  
  Compared with the control mice, the HFD mice had impaired brain insulin signaling, exacerbated AD neuropathology, defects in synaptic stability/plasticity, and apoptotic neuronal cell death in conjunction with exacerbated cognitive deficits in the affected brain regions, which were all significantly alleviated in the HFD + EX mice.
  
  
  
  The current findings suggest that treadmill running protects against AD-like disease progression and cognitive deficits caused by an HFD in the 3xTg-AD mice.
authors.affiliation: College of Sport Science, Sungkyunkwan University, Suwon, REPUBLIC OF KOREA.
authors.forename: Donghyun
authors.initials: D
authors.lastname: Kim
authors.forename: Jinkyung
authors.initials: J
authors.lastname: Cho
authors.forename: Inhwan
authors.initials: I
authors.lastname: Lee
authors.forename: Youngyun
authors.initials: Y
authors.lastname: Jin
authors.forename: Hyunsik
authors.initials: H
authors.lastname: Kang
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism / Q000503:physiopathology*; D000682:Amyloid / Q000378:metabolism; D000818:Animals; D017209:Apoptosis; D001786:Blood Glucose / Q000378:metabolism; D001921:Brain / Q000378:metabolism; D019208:Brain-Derived Neurotrophic Factor; D002784:Cholesterol / Q000097:blood; D059305:Diet, High-Fat; D004195:Disease Models, Animal; D018450:Disease Progression; D015536:Down-Regulation; D007328:Insulin / Q000097:blood / Q000378:metabolism; D008297:Male; D008822:Mice, Transgenic; D009473:Neuronal Plasticity; D010805:Physical Conditioning, Animal / Q000502:physiology*; D012420:Running / Q000502:physiology; D014280:Triglycerides / Q000097:blood; D016875:tau Proteins / Q000378:metabolism
chemical_list: D000682:Amyloid; D001786:Blood Glucose; D019208:Brain-Derived Neurotrophic Factor; D007328:Insulin; D014280:Triglycerides; D016875:tau Proteins; D002784:Cholesterol