title: Monitoring of organochlorine pesticides in blood of women with uterine cervix cancer.
abstract: In Yucatan, Mexico, chronic exposure of Mayan population to pesticides is expected as about 30 per cent are drinking polluted water. Residues of organochlorine pesticides (OCP) were monitored in 18 municipalities of Yucatan with high mortality rates due to uterine cervix cancer. 70 blood samples collected from Mayan women living in livestock, agricultural and metropolitan area were analyzed for OCP. Solid Phase Extraction was performed on C18 cartridges and analyzed by Gas Chromatography with Electron Capture Detector. The results showed that the highest OCP levels were detected in blood of women living in the livestock area. OCP detected were endosulfan I (7.35 μg/mL), aldrin (3.69 μg/mL), 4,4' DDD (2.33 μg/mL), 1.39 and 1.46 μg/mL of δ-HCH. Women from the agricultural area had high concentrations of OCP in their blood, particularly dieldrin (1.19 μg/mL), and 1.26 μg/mL of 4,4' DDE. In the metropolitan area, 0.080 μg/mL of γ-HCH and 0.064 μg/mL of heptachlore were detected. This monitoring study was also based on epidemiological data of uterine cervical cancer. It was found that environmental factors may have facilitated the infiltration of OCP to the aquifer used for potable water supply. These factors in addition to poverty can have impacts on public health. This first exploratory study suggests that monitoring of OCP in human is important for the establishment of health promotion programs. The integrative analysis of both, environmental and social factors would be helpful to characterize the bioaccumulation of pesticides in humans.
authors.affiliation: Laboratorio de Medicina Social y Salud Pública, Centro de Investigaciones Regionales, Universidad Autónoma de Yucatán, Av. Itzáez x 59 #490, Centro, C.P. 97000, Mérida, Yucatán, Mexico. Electronic address: polanco07@gmail.com.
authors.forename: Ángel G
authors.initials: ÁG
authors.lastname: Polanco Rodríguez
authors.affiliation: UNESCO/UNITWIN Wicop, Departamento de Química Física, Facultad de Ciencias del Mar y Ambientales, Universidad de Cádiz, Puerto Real, Cádiz, Spain.
authors.forename: M Inmaculada
authors.initials: MI
authors.lastname: Riba López
authors.affiliation: UNESCO/UNITWIN Wicop, Departamento de Química Física, Facultad de Ciencias del Mar y Ambientales, Universidad de Cádiz, Puerto Real, Cádiz, Spain.
authors.forename: T Ángel
authors.initials: TÁ
authors.lastname: DelValls Casillas
authors.affiliation: Laboratorio de Cromatografía, Facultad de Química, Universidad Autónoma de Yucatán, C. 43 No. 613 x C. 90 Col. Inalámbrica, C.P. 97069, Mérida, Yucatán, Mexico.
authors.forename: J Alfredo
authors.initials: JA
authors.lastname: Araujo León
authors.affiliation: National Research Institute for Rural Engineering, Water, and Forestry, Hédi Karrai Street, P.O. Box 10, 2080, Ariana, Tunisia.
authors.forename: Olfa
authors.initials: O
authors.lastname: Mahjoub
authors.affiliation: Environmental Impact Assessment Division, Gujarat Institute of Desert Ecology, Post Box - 83, Mundra Road, Opp. Changleshwar Temple, Bhuj 370001, Gujarat, India.
authors.forename: Anjan Kumar
authors.initials: AK
authors.lastname: Prusty
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000383:Agriculture; D002584:Cervix Uteri / Q000503:physiopathology; D002849:Chromatography, Gas; D004784:Environmental Monitoring; D005260:Female; D060587:Groundwater / Q000737:chemistry; D001556:Hexachlorocyclohexane; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000097:blood* / Q000633:toxicity*; D008800:Mexico; D008875:Middle Aged; D010573:Pesticide Residues / Q000097:blood* / Q000633:toxicity*; D014594:Uterine Neoplasms / Q000209:etiology* / Q000503:physiopathology; D014874:Water Pollutants, Chemical / Q000097:blood* / Q000633:toxicity*
chemical_list: D006843:Hydrocarbons, Chlorinated; D010573:Pesticide Residues; D014874:Water Pollutants, Chemical; C086916:delta-hexachlorocyclohexane; D001556:Hexachlorocyclohexane
keywords: Blood; Organochlorine pesticides; Uterine cervix cancer; Water; Women