title: In-vivomonitoring of tissue oxygen saturation in deep brain structures using a single fiber optical system.
abstract: We propose a single fiber optical system for monitoring tissue oxygen saturation (sO2) based on continuous-wave reflectance spectroscopy in the visible wavelengths. The system is designed for measurements in deep brain structures by stereotaxically implanting the 200μm-core fiber probe into the tissue of interest. Monte Carlo (MC) simulations were used to estimate the measurement tissue volume between 0.02-0.03 mm3. Experiments in an optical phantom indicated the system had a root mean squared error (RMSE) of 4.21% compared with a commercial fluorescence-based tissue oxygen partial pressure measuring system. Finally, we used the system for continuously monitoring tissuesO2from a highly-localized volume in anesthetized mice.
authors.affiliation: Electrical and Computer Engineering, Schulich School of Engineering, University of Calgary, Canada.
authors.forename: Linhui
authors.initials: L
authors.lastname: Yu
authors.affiliation: Department of Radiology, Cumming School of Medicine, University of Calgary, Canada.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Department of Radiology, Cumming School of Medicine, University of Calgary, Canada; Hotchkiss Brain Institute, University of Calgary, Canada; Experimental Imaging Centre, University of Calgary, Canada.
authors.forename: Jeff F
authors.initials: JF
authors.lastname: Dunn
authors.affiliation: Electrical and Computer Engineering, Schulich School of Engineering, University of Calgary, Canada; Hotchkiss Brain Institute, University of Calgary, Canada.
authors.forename: Kartikeya
authors.initials: K
authors.lastname: Murari
keywords: (170.1470) Blood or tissue constituent monitoring; (170.3660) Light propagation in tissues; (170.3890) Medical optics instrumentation; (170.6510) Spectroscopy, tissue diagnostics