title: [Correlation analysis of G870A CCND1 gene polymorphism with digestive system tumors].
abstract: OBJECTIVE
  To study the correlation of G870A CCND1 gene polymorphism and digestive system tumors.
  
  
  METHODS
  From August 2010 to August 2014, 164 digestive system cancer patients (including 82 patients with gastric cancer and 82 with colorectal cancer) and 82 healthy subjects (control group) were examined with PCR-restriction fragment length polymorphism (PCR-RFLP). The distribution of CCND1 gene G870A frequency in the 3 groups and its association with tumor staging and grading were analyzed.
  
  
  RESULTS
  The frequencies of the GG, GA and AA genotypes in G870A CCND1 gene loci in patients with gastric cancer and colorectal cancer differed significantly from those in the control group (P<0.05). G870A CCND1 gene polymorphism was closely associated with an increased risk of digestive system tumors (P<0.05). The GA and AA genotypes were associated with a significantly higher risk of digestive system cancer risk than the GG genotype (P<0.05), and their frequencies were significantly higher in patients with tumors of higher pathological grade and in those in advanced tumor stages (P<0.05).
  
  
  CONCLUSIONS
  G870A CCND1 gene polymorphism is associated with the risk of digestive system tumors. The allele A is associated with an increased risk of digestive system tumors and correlated with the tumor differentiation and staging of the tumor.
authors.affiliation: Jiaozuo Worker Medical School, Jiaozuo 454000, China.E-mail: 443040862@qq.com.
authors.forename: Shu-Min
authors.initials: SM
authors.lastname: Yang
authors.forename: Ya-Lin
authors.initials: YL
authors.lastname: Shi
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D019938:Cyclin D1 / Q000235:genetics*; D005770:Gastrointestinal Neoplasms / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length
chemical_list: C530104:CCND1 protein, human; D019938:Cyclin D1