title: Brazilian-Portuguese translation, cross-cultural adaptation and validation of the Myasthenia Gravis Composite scale. A multicentric study.
abstract: OBJECTIVE
  To perform the translation, cultural adaptation and validation of the Myasthenia Gravis Composite (MGC) scale in Brazil.
  
  
  METHODS
  The study was conducted at three neuromuscular disease research centers in accordance with the international ethical standards, following a multi-modal approach and was conducted in three steps consisting of translation, cultural adaptation, and validation according to international guidelines. The final version of the MGC was applied in a sample of 27 MG patients and the total score was compared to a Portuguese version of the MG-QOL-15.
  
  
  RESULTS
  The internal consistency verified by Cohen's Kappa test was excellent (0.766). The correlation between the MGC and MG-QOL-15 was strong (R = 0.777; p = 0.000). No significant differences were found between the responses of patients in the first and second applications of the MGC.
  
  
  CONCLUSIONS
  The MGC scale, validated into Brazilian Portuguese, has proven to be a reliable instrument that is easy to use, and is highly reproducible.
authors.affiliation: Universidade Nove de Julho, Programa de Pós Graduação Mestrado e Doutorado em Ciências da Reabilitação, São Paulo SP, Brasil.
authors.forename: Ezequiel Fernandes
authors.initials: EF
authors.lastname: Oliveira
authors.affiliation: Universidade Federal de São Paulo, Departamento de Neurologia e Neurocirurgia, Divisão de Doença Neuromuscular, São Paulo SP, Brasill.
authors.forename: Valéria Cavalcante
authors.initials: VC
authors.lastname: Lima
authors.affiliation: Faculdade de Ciências Médicas da Santa Casa de São Paulo, Programa de Mestrado e Doutorado em Pesquisa em Cirurgia, São Paulo SP, Brasil.
authors.forename: Eduardo Araujo
authors.initials: EA
authors.lastname: Perez
authors.affiliation: Faculdade de Ciências Médicas da Santa Casa de São Paulo, Departamento de Clínica Médica, Disciplina de Neurologia, São Paulo SP, Brasil.
authors.forename: Melissa Nunes
authors.initials: MN
authors.lastname: Polaro
authors.affiliation: Faculdade de Ciências Médicas da Santa Casa de São Paulo, Departamento de Clínica Médica, Disciplina de Neurologia, São Paulo SP, Brasil.
authors.forename: Berenice Cataldo Oliveira
authors.initials: BC
authors.lastname: Valério
authors.affiliation: Hospital do Servidor Público Estadual, Programa de Pós Graduação em Ciências da Saúde, São Paulo SP, Brasil.
authors.forename: João R
authors.initials: JR
authors.lastname: Pereiro
authors.affiliation: Hospital do Servidor Público Estadual, Programa de Pós Graduação em Ciências da Saúde, São Paulo SP, Brasil.
authors.forename: Sergio Roberto
authors.initials: SR
authors.lastname: Nacif
authors.affiliation: Universidade Nove de Julho, Programa de Pós Graduação Mestrado e Doutorado em Ciências da Reabilitação, São Paulo SP, Brasil.
authors.forename: Claudia Santos
authors.initials: CS
authors.lastname: Oliveira
authors.affiliation: Universidade Federal de São Paulo, Departamento de Neurologia e Neurocirurgia, Divisão de Doença Neuromuscular, São Paulo SP, Brasill.
authors.forename: Acary Souza Bulle
authors.initials: AS
authors.lastname: Oliveira
authors.affiliation: Universidade Nove de Julho, Programa de Pós Graduação Mestrado e Doutorado em Ciências da Reabilitação, São Paulo SP, Brasil.
authors.forename: Luis Vicente Franco
authors.initials: LV
authors.lastname: Oliveira
mesh_terms: D000328:Adult; D000368:Aged; D001938:Brazil; D002986:Clinical Trials as Topic; D003431:Cross-Cultural Comparison; D005260:Female; D006801:Humans; D007802:Language; D008297:Male; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000503:physiopathology*; D011594:Psychometrics / Q000379:methods; D011788:Quality of Life; D015203:Reproducibility of Results; D011795:Surveys and Questionnaires; D014177:Translations