title: Modulation of Microbiota-Gut-Brain Axis by Berberine Resulting in Improved Metabolic Status in High-Fat Diet-Fed Rats.
abstract: To investigate whether or not berberine could improve metabolic status of high-fat-fed rats through modulation of microbiota-gut-brain axis.
  
  
  
  Berberine was administered on high-fat-fed Sprague-Dawley rats. Brain-gut hormones were detected, and changes of gut microbiota were analyzed by 16S rRNA gene sequencing.
  
  
  
  Berberine could reduce weight gain and lipolysis in the high-fat diet-fed group. Moreover, trends of ameliorated insulin resistance and decreased endogenous glucose production were observed. In addition, the microbiota-gut-brain axis was found to be modulated, including structural and diversity changes of microbiota, elevated serum glucagon-like peptide-1 and neuropeptide Y level, decreased orexin A level, up-regulated glucagon-like peptide-1 receptor mRNA level as well as ultra-structural improvement of the hypothalamus.
  
  
  
  Taken together, our findings suggest that berberine improved metabolic disorders induced by high-fat diet through modulation of the microbiota-gut-brain axis.
authors.affiliation: Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.
authors.forename: Honglin
authors.initials: H
authors.lastname: Sun
authors.forename: Ningjian
authors.initials: N
authors.lastname: Wang
authors.forename: Zhen
authors.initials: Z
authors.lastname: Cang
authors.forename: Chaoxia
authors.initials: C
authors.lastname: Zhu
authors.forename: Li
authors.initials: L
authors.lastname: Zhao
authors.forename: Xiaomin
authors.initials: X
authors.lastname: Nie
authors.forename: Jing
authors.initials: J
authors.lastname: Cheng
authors.forename: Fangzhen
authors.initials: F
authors.lastname: Xia
authors.forename: Hualing
authors.initials: H
authors.lastname: Zhai
authors.forename: Yingli
authors.initials: Y
authors.lastname: Lu
mesh_terms: D000818:Animals; D001599:Berberine / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects* / Q000502:physiology; D059305:Diet, High-Fat; D004734:Energy Metabolism / Q000187:drug effects*; D000069196:Gastrointestinal Microbiome / Q000187:drug effects*; D052216:Glucagon-Like Peptide 1; D007333:Insulin Resistance; D007422:Intestines / Q000187:drug effects* / Q000382:microbiology / Q000502:physiology; D008297:Male; D012336:RNA, Ribosomal, 16S; D051381:Rats; D017207:Rats, Sprague-Dawley; D015398:Signal Transduction / Q000187:drug effects; D015430:Weight Gain / Q000187:drug effects
chemical_list: D012336:RNA, Ribosomal, 16S; D001599:Berberine; D052216:Glucagon-Like Peptide 1