title: Assembly of cells and vesicles for organ engineering.
abstract: The development of materials and technologies for the assembly of cells and/or vesicles is a key for the next generation of tissue engineering. Since the introduction of the tissue engineering concept in 1993, various types of scaffolds have been developed for the regeneration of connective tissuesin vitroandin vivo. Cartilage, bone and skin have been successfully regeneratedin vitro, and these regenerated tissues have been applied clinically. However, organs such as the liver and pancreas constitute numerous cell types, contain small amounts of extracellular matrix, and are highly vascularized. Therefore, organ engineering will require the assembly of cells and/or vesicles. In particular, adhesion between cells/vesicles will be required for regeneration of organsin vitro. This review introduces and discusses the key technologies and materials for the assembly of cells/vesicles for organ regeneration.
authors.affiliation: Biofunctional Materials Unit, Nano-Bio Field, Materials Nanoarchitectonics (MANA), National Institute for Materials Science, 1-1 Namiki, Tsukuba, Ibaraki, 305-0044, Japan.
authors.forename: Tetsushi
authors.initials: T
authors.lastname: Taguchi
keywords: assembly; cell; material; organ engineering; technology; vesicle