title: Pyoderma gangrenosum with spleen involvement. Review of the literature and case report.
abstract: BACKGROUND
  Pyoderma gangrenosum is a rare, ulcerative, destructive, non-infectious dermatologic disease and it is one clinical entity within the spectrum of neutrophilic dermatoses. Visceral involvement, manifesting as sterile neutrophilic infiltrates in sites other than skin and, is infrequent. Splenic involvement is very rare.
  
  
  METHODS
  We present a case of a 58-year-old woman with pyoderma gangrenosum with spleen involvement and review all reports of similar cases.We have found nine reported cases, our case being the tenth.
  
  
  CONCLUSIONS
  Our review showed that spleen involvement in the course of pyoderma gangrenosum can occur at any age. It is slightly more frequent in men. An underlying or associated neutrophilic disorder is present in almost half of the patients. Skin manifestations were usually present before splenic involvement. In most cases the disese responds well to glucocorticosteroids.
authors.affiliation: Iuliu Hațieganu University of Medicine and Pharmacy, Department of Dermatology, Cluj-Napoca, Romania.
authors.forename: Rodica
authors.initials: R
authors.lastname: Cosgarea
authors.affiliation: Iuliu Hațieganu University of Medicine and Pharmacy, Department of Dermatology, Cluj-Napoca, Romania.
authors.forename: Simona Corina
authors.initials: SC
authors.lastname: Senilă
authors.affiliation: Ultrasonography Laboratory, Imaging and Radiology Department, "Octavian Fodor" Gastroenterology and Hepatology Regional Institute, Cluj-Napoca, Romania.
authors.forename: Radu
authors.initials: R
authors.lastname: Badea
authors.affiliation: Iuliu Hațieganu University of Medicine and Pharmacy, Department of Dermatology, Cluj-Napoca, Romania.
authors.forename: Loredana
authors.initials: L
authors.lastname: Ungureanu
keywords: bowel infarction; dapson; eye; neutrophils; ophthalmology; peritonitis; pyoderma gangrenosum; skin ulcers