title: The reproducibility of biomedical research: Sleepers awake!
abstract: There is increasing concern about the reliability of biomedical research, with recent articles suggesting that up to 85% of research funding is wasted. This article argues that an important reason for this is the inappropriate use of molecular techniques, particularly in the field of RNA biomarkers, coupled with a tendency to exaggerate the importance of research findings.
authors.affiliation: Faculty of Medical Science, Postgraduate Medical Institute, Anglia Ruskin University, Chelmsford CM1 1SQ, UK.
authors.forename: Stephen A
authors.initials: SA
authors.lastname: Bustin
keywords: Biomedicine; Cancer; Microarrays; Next generation sequencing; Reproducibility; qPCR