title: Cortical interneuron specification: the juncture of genes, time and geometry.
abstract: A fundamental question in developmental neuroscience is how hundreds of diverse cell types are generated to form specialized brain regions. The ganglionic eminences (GEs) are embryonic brain structures located in the ventral telencephalon that produce many inhibitory GABA (γ-Aminobutyric acid)-ergic cell types, including long-range projection neurons and local interneurons (INs), which disperse widely throughout the brain. While much has been discovered about the origin and wiring of these cells, a major question remains: how do neurons originating in the GEs become specified during development as one differentiated subtype versus another? This review will cover recent work that has advanced our knowledge of the mechanisms governing cortical interneuron subtype specification, particularly progenitors' spatial origin, birthdates, lineage, and mode of division.
authors.affiliation: NYU Neuroscience Institute, Langone Medical Center, New York, NY, USA.
authors.forename: Rachel C
authors.initials: RC
authors.lastname: Bandler
authors.affiliation: NYU Neuroscience Institute, Langone Medical Center, New York, NY, USA.
authors.forename: Christian
authors.initials: C
authors.lastname: Mayer
authors.affiliation: NYU Neuroscience Institute, Langone Medical Center, New York, NY, USA. Electronic address: fisheg01@nyumc.org.
authors.forename: Gord
authors.initials: G
authors.lastname: Fishell
mesh_terms: D001921:Brain / Q000166:cytology* / Q000196:embryology; D002454:Cell Differentiation; D006801:Humans; D007395:Interneurons / Q000166:cytology*; D009474:Neurons / Q000166:cytology; D013687:Telencephalon / Q000166:cytology / Q000201:enzymology