title: Efficacy and Safety of Cream Containing Climbazole/Piroctone Olamine for Facial Seborrheic Dermatitis: A Single-Center, Open-Label Split-Face Clinical Study.
abstract: BACKGROUND
  Seborrheic dermatitis (SD) is a multifactorial disease;Malasseziaspecies play an important role in its pathogenesis.
  
  
  OBJECTIVE
  We aimed to determine whether a cream containing climbazole/piroctone olamine (C/P cream), antifungal agents with expected efficacy againstMalasseziaspecies, could improve SD symptoms.
  
  
  METHODS
  We instructed 24 patients with mild-to-moderate SD to apply the C/P cream and emollient cream on the right and left sides of the face, respectively, every morning and evening for 4 weeks. The casual sebum level (measured with Sebumeter®; Courage & Khazaka Electronic GmbH, Germany) and the extent of erythema (measured with Mexameter®; Courage & Khazaka Electronic GmbH) on the face were measured at baseline and after 4 weeks. The minimal inhibitory concentration (MIC) was determined to demonstrate the antifungal activity of the C/P cream.
  
  
  RESULTS
  The casual sebum level and erythema were measured at week 4, and the median values demonstrated a quantitative improvement on the C/P cream-treated right side of the face compared to the emollient cream-treated left side. For the C/P cream, the MICs were 0.625, 5, 0.625, and 2.5 mg/ml forMalassezia restricta,M. globosa,M. sympodialis, andM. slooffiae, respectively.
  
  
  CONCLUSIONS
  Based on the reduced casual sebum level and extent of erythema, the antifungal activity of C/P cream againstMalasseziaspecies seems useful for the treatment of mild to moderate SD.
authors.affiliation: Department of Dermatology, Konkuk University School of Medicine, Seoul, Korea.
authors.forename: Hae Jeong
authors.initials: HJ
authors.lastname: Youn
authors.affiliation: Department of Dermatology, Konkuk University School of Medicine, Seoul, Korea.
authors.forename: Soo Young
authors.initials: SY
authors.lastname: Kim
authors.affiliation: Department of Systems Biotechnology, Chung-Ang University, Anseong, Korea.
authors.forename: Minji
authors.initials: M
authors.lastname: Park
authors.affiliation: Department of Systems Biotechnology, Chung-Ang University, Anseong, Korea.
authors.forename: Won Hee
authors.initials: WH
authors.lastname: Jung
authors.affiliation: Department of Dermatology, Konkuk University School of Medicine, Seoul, Korea.; Research Institute of Medical Science, Konkuk University, Seoul, Korea.
authors.forename: Yang Won
authors.initials: YW
authors.lastname: Lee
authors.affiliation: Department of Dermatology, Konkuk University School of Medicine, Seoul, Korea.; Research Institute of Medical Science, Konkuk University, Seoul, Korea.
authors.forename: Yong Beom
authors.initials: YB
authors.lastname: Choe
authors.affiliation: Department of Dermatology, Konkuk University School of Medicine, Seoul, Korea.; Research Institute of Medical Science, Konkuk University, Seoul, Korea.
authors.forename: Kyu Joong
authors.initials: KJ
authors.lastname: Ahn
keywords: Climbazole; Malassezia species; Piroctone olamine; Seborrheic dermatitis