title: Ten years experience with breast reconstruction after salvage mastectomy in previously irradiated patients: analysis of outcomes, satisfaction and well-being.
abstract: Reconstruction following mastectomy offers women an opportunity to mollify some of the emotional and aesthetic effects of this devastating disease.
  
  
  
  The authors reviewed the files of 83 patients who underwent immediate postmastectomy reconstruction with tissue expander between January of 2003 and June of 2012 at our hospital. The patients were divided into two groups: Group A (study group) included 30 patients with previous quadrantectomy and radiotherapy who underwent salvage mastectomy after local recurrence; Group B (control group) included 53 patients submitted to primary radical mastectomy. We submitted Breast-Q reconstruction post-operative module to all of our patients.
  
  
  
  The median follow-up time for the whole group was 36 months (range = 12-144 months). Between group A and group B, there were no significant differences. In the group A, the median time from RT to reconstruction was 24 months (range = 9-192 months). The overall rate of complications was not similar between the two groups (66.6% vs. 58.5%; p = NS). However, the  major complications occurred mostly in the irradiated group, showing a trend of statistical significance (53.3% vs. 32.0%; p = 0.07). In this group, the occurrence of major complications was not different according to time from RT to reconstruction (p = 0.313). In particularly, patients from the irradiated group (group A) had a significantly higher risk of grade III-IV capsular contracture (relative risk 3.75, p = 0.02) and autologous salvage reconstruction (relative risk 10.4, p = 0.02).
  
  
  
  The results of this study prove that heterologous reconstruction is still possible following salvage mastectomy in previously irradiated patients.
authors.affiliation: Plastic and Reconstructive Surgery Unit, Campus Bio-Medico University, Rome, Italy. maurosabbarone@gmail.com.
authors.forename: B
authors.initials: B
authors.lastname: Cagli
authors.forename: M
authors.initials: M
authors.lastname: Barone
authors.forename: E
authors.initials: E
authors.lastname: Ippolito
authors.forename: A
authors.initials: A
authors.lastname: Cogliandro
authors.forename: S
authors.initials: S
authors.lastname: Silipigni
authors.forename: S
authors.initials: S
authors.lastname: Ramella
authors.forename: P
authors.initials: P
authors.lastname: Persichetti
mesh_terms: D001943:Breast Neoplasms / Q000523:psychology* / Q000601:surgery*; D005260:Female; D006801:Humans; D016462:Mammaplasty; D008408:Mastectomy; D009364:Neoplasm Recurrence, Local / Q000601:surgery; D010549:Personal Satisfaction; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome