title: Photoacoustic mammography capable of simultaneously acquiring photoacoustic and ultrasound images.
abstract: We have constructed a prototype photoacoustic mammography system (PAM-02) capable of simultaneously acquiring photoacoustic (PA) and ultrasound (US) images. Each PA, US, and fused PA/US image can be acquired over a wide area of the breast using the scanning module of a US transducer, a PA detector, and optical prisms. The resolution of the PA images exhibits improvement from 2 to 1 mm compared to images acquired using our previous prototype. The maximum scan area of PAM-02 is 90 mm along the horizontal axis and 150 mm along the vertical axis. In a phantom experiment, the available depth was at least 45 mm. A representative example of the application of the PAM-02 prototype in clinical research at Kyoto University is presented and shows S-factor images, which are considered an approximation parameter related to hemoglobin saturation of tumor-related blood vessels. We confirmed the applicability of the system for anatomical and biological research.
authors.affiliation: Canon Inc., Medical Imaging Development Center, 3-30-2, Shimomaruko, Ohta-ku, Tokyo 1468501, JapanbKyoto University, Graduate School of Medicine, Department of Breast Surgery, 54 Shogoin-Kawaharacho Sakyo-ku, Kyoto 6068507, Japan.
authors.forename: Yasufumi
authors.initials: Y
authors.lastname: Asao
authors.affiliation: Canon Inc., Medical Imaging Development Center, 3-30-2, Shimomaruko, Ohta-ku, Tokyo 1468501, Japan.
authors.forename: Yohei
authors.initials: Y
authors.lastname: Hashizume
authors.affiliation: Canon Inc., Medical Imaging Development Center, 3-30-2, Shimomaruko, Ohta-ku, Tokyo 1468501, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Suita
authors.affiliation: Canon Inc., Medical Imaging Development Center, 3-30-2, Shimomaruko, Ohta-ku, Tokyo 1468501, Japan.
authors.forename: Ken-Ichi
authors.initials: KI
authors.lastname: Nagae
authors.affiliation: Canon Inc., Medical Imaging Development Center, 3-30-2, Shimomaruko, Ohta-ku, Tokyo 1468501, Japan.
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Fukutani
authors.affiliation: Canon Inc., Medical Imaging Development Center, 3-30-2, Shimomaruko, Ohta-ku, Tokyo 1468501, Japan.
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Sudo
authors.affiliation: Canon Inc., Medical Imaging Development Center, 3-30-2, Shimomaruko, Ohta-ku, Tokyo 1468501, Japan.
authors.forename: Toshikazu
authors.initials: T
authors.lastname: Matsushita
authors.affiliation: Canon Inc., Medical Imaging Development Center, 3-30-2, Shimomaruko, Ohta-ku, Tokyo 1468501, Japan.
authors.forename: Shuichi
authors.initials: S
authors.lastname: Kobayashi
authors.affiliation: Kyoto University, Graduate School of Medicine, Department of Breast Surgery, 54 Shogoin-Kawaharacho Sakyo-ku, Kyoto 6068507, Japan.
authors.forename: Mariko
authors.initials: M
authors.lastname: Tokiwa
authors.affiliation: Kyoto University, Graduate School of Medicine, Department of Breast Surgery, 54 Shogoin-Kawaharacho Sakyo-ku, Kyoto 6068507, Japan.
authors.forename: Iku
authors.initials: I
authors.lastname: Yamaga
authors.affiliation: Kyoto University, Graduate School of Medicine, Department of Breast Surgery, 54 Shogoin-Kawaharacho Sakyo-ku, Kyoto 6068507, Japan.
authors.forename: Elham
authors.initials: E
authors.lastname: Fakhrejahani
authors.affiliation: Kyoto University, Graduate School of Medicine, Department of Breast Surgery, 54 Shogoin-Kawaharacho Sakyo-ku, Kyoto 6068507, Japan.
authors.forename: Masae
authors.initials: M
authors.lastname: Torii
authors.affiliation: Kyoto University, Graduate School of Medicine, Department of Breast Surgery, 54 Shogoin-Kawaharacho Sakyo-ku, Kyoto 6068507, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kawashima
authors.affiliation: Kyoto University, Graduate School of Medicine, Department of Breast Surgery, 54 Shogoin-Kawaharacho Sakyo-ku, Kyoto 6068507, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Takada
authors.affiliation: Kyoto University, Graduate School of Medicine, Department of Diagnostic Imaging and Nuclear Medicine, 54 Shogoin-Kawaharacho Sakyo-ku, Kyoto 6068507, Japan.
authors.forename: Shotaro
authors.initials: S
authors.lastname: Kanao
authors.affiliation: Kyoto University, Graduate School of Medicine, Department of Diagnostic Imaging and Nuclear Medicine, 54 Shogoin-Kawaharacho Sakyo-ku, Kyoto 6068507, Japan.
authors.forename: Masako
authors.initials: M
authors.lastname: Kataoka
authors.affiliation: Kyoto University, Graduate School of Medicine, Department of Human Health Science, 53 Shogoin-Kawaharacho Sakyo-ku, Kyoto 6068507, Japan.
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Shiina
authors.affiliation: Kyoto University, Graduate School of Medicine, Department of Breast Surgery, 54 Shogoin-Kawaharacho Sakyo-ku, Kyoto 6068507, Japan.
authors.forename: Masakazu
authors.initials: M
authors.lastname: Toi
mesh_terms: D000328:Adult; D000368:Aged; D000465:Algorithms; D001940:Breast / Q000000981:diagnostic imaging; D004867:Equipment Design; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008327:Mammography / Q000379:methods*; D019047:Phantoms, Imaging; D061088:Photoacoustic Techniques / Q000379:methods*; D014463:Ultrasonography / Q000379:methods*