title: Continuous Performance Test Is Sensitive to a Single Methylphenidate Challenge in Preschool Children With ADHD.
abstract: Objective:There is a lack of evidence-based diagnostic paradigms and personalized interventions for preschoolers with ADHD. This study aimed to evaluate the performance of preschoolers diagnosed with ADHD on a continuous performance test (CPT) before and after a single methylphenidate (MPH) challenge.Method:The Test of Variables of Attention (TOVA)-a CPT-was administered to 61 preschoolers (5.64 ± 0.69 years; 74% boys) with ADHD before and after a single MPH challenge (0.3 or 0.5 mg/kg). Baseline TOVA performance was correlated with Conners' Rating Scales (CRS) and compared with post-MPH TOVA performance.Results:A high rate of omission errors and several significant correlations between TOVA values and CRS scores were found at baseline. A single MPH administration improved TOVA performance significantly and was well tolerated.Conclusion:TOVA assessment may assist in the evaluation of the effect of MPH in preschoolers with ADHD and may help in planning interventions for them.
authors.affiliation: Geha Mental Health Center, Petah Tikva, Israel.|Tel Aviv University, Israel.
authors.forename: Miriam
authors.initials: M
authors.lastname: Peskin
authors.affiliation: Geha Mental Health Center, Petah Tikva, Israel.|Ariel University, Israel.
authors.forename: Eliane
authors.initials: E
authors.lastname: Sommerfeld
authors.affiliation: Geha Mental Health Center, Petah Tikva, Israel.
authors.forename: Yael
authors.initials: Y
authors.lastname: Basford
authors.affiliation: Geha Mental Health Center, Petah Tikva, Israel.
authors.forename: Shlomit
authors.initials: S
authors.lastname: Rozen
authors.affiliation: Geha Mental Health Center, Petah Tikva, Israel.|Tel Aviv University, Israel.|Columbia University, New York, NY, USA.
authors.forename: Gil
authors.initials: G
authors.lastname: Zalsman
authors.affiliation: Geha Mental Health Center, Petah Tikva, Israel.|Tel Aviv University, Israel.|Felsenstein Medical Research Center, Petah Tikva, Israel.
authors.forename: Abraham
authors.initials: A
authors.lastname: Weizman
authors.affiliation: Geha Mental Health Center, Petah Tikva, Israel.|Tel Aviv University, Israel.
authors.forename: Iris
authors.initials: I
authors.lastname: Manor
mesh_terms: D001288:Attention; D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy; D000697:Central Nervous System Stimulants / Q000627:therapeutic use; D002675:Child, Preschool; D006801:Humans; D008297:Male; D008774:Methylphenidate / Q000627:therapeutic use
chemical_list: D000697:Central Nervous System Stimulants; D008774:Methylphenidate
keywords: ADHD; continuous performance test; inattention; methylphenidate; preschoolers