title: Enantiomeric Resolution of (RS)-Naproxen and Application of (S)- Naproxen in the Direct and Indirect Enantioseparation of Racemic Compounds by Liquid Chromatography: A Review.
abstract: (S)-Naproxen (Npx), an α-aryl propionic acid derivative, belongs to the class of Non-Steroidal Anti-Inflammatory Drugs and is easily available in pure (S)-form. (S)-Npx has been used as a chiral selector for chromatographic separation of a variety of racemates, using both direct and indirect methods, and has been found to be useful and successful as a basic chiral moiety. This review article describes methods for enantioseparation of (RS)-Npx, development of chiral stationary phases based on (S)-Npx and preparation of novel chiral derivatizing reagents synthesized from (S)-Npx along with their application for enantioseparation of several pharmaceutically important racemates.
authors.affiliation: Department of Basic and Applied Sciences, GD Goenka University, Gurgaon-122103, Italy.
authors.forename: Sonika
authors.initials: S
authors.lastname: Batra
authors.affiliation: Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee-247667, India.
authors.forename: Ravi
authors.initials: R
authors.lastname: Bhushan
mesh_terms: D002853:Chromatography, Liquid / Q000379:methods*; D009288:Naproxen / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D009288:Naproxen
keywords: (S)-Naproxen; chiral derivatizing reagents; chiral stationary phase; enantioseparation; liquid chromatography; racemic pharmaceuticals