title: Physicochemical/photophysical characterization and angiogenic properties of Curcuma longa essential oil.
abstract: This study analyzed the physicochemical and photophysical properties of essential oil of Curcuma longa and its angiogenic potential. The results showed that curcumin is the main fluorescent component present in the oil, although the amount is relatively small. The experimental chorioallantoic membrane model was used to evaluate angiogenic activity, showing a significant increase in the vascular network of Curcuma longa and positive control groups when compared to the neutral and inhibitor controls (P <0.05), but no significant difference was found between Curcuma longa essential oil and the positive control (P >0.05). Histological analysis showed extensive neovascularization, hyperemia and inflammation in the positive control group and Curcuma longa when compared to other controls (P <0.05), characteristic factors of the angiogenesis process. In conclusion, Curcuma longa oil showed considerable proangiogenic activity and could be a potential compound in medical applications.
authors.affiliation: Universidade Federal de Goiás, Biotecnologia e Biodiversidade, Campus Samambaia, ICB IV, Avenida Esperança, Setor Itatiaia, 74001-970 Goiânia, GO, Brasil.
authors.forename: Lilhian A
authors.initials: LA
authors.lastname: Araújo
authors.affiliation: Pontifícia Universidade Católica de Goiás, Laboratório de Estudos Experimentais e Biotecnológicos, Área V, Rua 232, 128, 74605-140 Goiânia, GO, Brasil.
authors.forename: Rafael G M
authors.initials: RG
authors.lastname: Araújo
authors.affiliation: Pontifícia Universidade Católica de Goiás, Laboratório de Estudos Experimentais e Biotecnológicos, Área V, Rua 232, 128, 74605-140 Goiânia, GO, Brasil.
authors.forename: Flávia O
authors.initials: FO
authors.lastname: Gomes
authors.affiliation: Universidade Federal de Goiás, Biotecnologia e Biodiversidade, Campus Samambaia, ICB IV, Avenida Esperança, Setor Itatiaia, 74001-970 Goiânia, GO, Brasil.
authors.forename: Susy R
authors.initials: SR
authors.lastname: Lemes
authors.affiliation: Universidade Estadual de Goiás, UnU-Ipameri, Rodovia GO-330, Km 241 Anel Viário, 75780-000 Ipameri, GO, Brasil.
authors.forename: Luciane M
authors.initials: LM
authors.lastname: Almeida
authors.affiliation: Instituto de Física, Universidade Federal de Goiás, Campus Samambaia, Avenida Esperança, Setor Itatiaia, 74001-970 Goiânia, GO, Brasil.
authors.forename: Lauro J Q
authors.initials: LJ
authors.lastname: Maia
authors.affiliation: Instituto de Física, Universidade Federal de Goiás, Campus Samambaia, Avenida Esperança, Setor Itatiaia, 74001-970 Goiânia, GO, Brasil.
authors.forename: Pablo J
authors.initials: PJ
authors.lastname: Gonçalves
authors.affiliation: Pontifícia Universidade Católica de Goiás, Laboratório de Estudos Experimentais e Biotecnológicos, Área V, Rua 232, 128, 74605-140 Goiânia, GO, Brasil.
authors.forename: Fátima
authors.initials: F
authors.lastname: Mrué
authors.affiliation: Pontifícia Universidade Católica de Goiás, Laboratório de Estudos Experimentais e Biotecnológicos, Área V, Rua 232, 128, 74605-140 Goiânia, GO, Brasil.
authors.forename: Nelson J
authors.initials: NJ
authors.lastname: Silva-Junior
authors.affiliation: Pontifícia Universidade Católica de Goiás, Laboratório de Estudos Experimentais e Biotecnológicos, Área V, Rua 232, 128, 74605-140 Goiânia, GO, Brasil.
authors.forename: Paulo R DE
authors.initials: PR
authors.lastname: Melo-Reis
mesh_terms: D043925:Angiogenesis Inducing Agents / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D002645:Chickens; D049033:Chorioallantoic Membrane / Q000098:blood supply / Q000187:drug effects; D030024:Curcuma / Q000737:chemistry*; D003474:Curcumin / Q000032:analysis; D006940:Hyperemia / Q000139:chemically induced; D007249:Inflammation / Q000139:chemically induced; D018919:Neovascularization, Physiologic / Q000187:drug effects; D009822:Oils, Volatile / Q000737:chemistry* / Q000494:pharmacology*; D010938:Plant Oils / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D043925:Angiogenesis Inducing Agents; D009822:Oils, Volatile; D010938:Plant Oils; D003474:Curcumin