title: Clinical implications of a rare renal entity: Pleomorphic Hyalinizing Angiectatic Tumor (PHAT).
abstract: Pleomorphic Hyalinizing Angiectatic Tumor (PHAT) is a rare benign lesion characterized by slow growth, infiltrative behavior and high rate of local recurrences. Only one case has been described in retroperitoneum, at renal hilum, but not involving pelvis or parenchyma. Here we present the first case of PHAT arising in the renal parenchyma. A nodular lesion in right kidney lower pole was diagnosed to a 61 year old woman. The patient underwent right nephrectomy. Microscopically, the lesion showed solid and pseudo-cystic components with hemorrhagic areas characterized by aggregates of ectatic blood vessels. Pleomorphic cells were characterized by large eosinophilic cytoplasm with irregular and hyperchromatic nuclei. Immunohistochemistry was performed and the lesion was classified as a Pleomorphic Hyalinizing Angiectatic Tumor (PHAT). Due to the clinical behavior of this tumor, in spite of its benign nature, review of the surgical margins and close follow up after partial nephrectomy are mandatory.
authors.affiliation: Section of Urology, Department of Surgical Oncological and Stomathological Science, University of Palermo, via del Vespro 129, 90100, Palermo, Italy. Electronic address: cristinasc1986@gmail.com.
authors.forename: Cristina
authors.initials: C
authors.lastname: Scalici Gesolfo
authors.affiliation: Section of Urology, Department of Surgical Oncological and Stomathological Science, University of Palermo, via del Vespro 129, 90100, Palermo, Italy. Electronic address: vserretta@libero.it.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Serretta
authors.affiliation: Section of Urology, Department of Surgical Oncological and Stomathological Science, University of Palermo, via del Vespro 129, 90100, Palermo, Italy. Electronic address: fabridima90@gmail.com.
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Di Maida
authors.affiliation: Department of Human Pathology, University of Palermo, via Del Vespro 129, 90100, Palermo, Italy. Electronic address: giulio.giannone@unipa.it.
authors.forename: Giulio
authors.initials: G
authors.lastname: Giannone
authors.affiliation: Department of Human Pathology, University of Palermo, via Del Vespro 129, 90100, Palermo, Italy. Electronic address: elisabetta.barresi@unipa.it.
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Barresi
authors.affiliation: Department of Human Pathology, University of Palermo, via Del Vespro 129, 90100, Palermo, Italy. Electronic address: vito.franco@unipa.it.
authors.forename: Vito
authors.initials: V
authors.lastname: Franco
authors.affiliation: Section of Pathological Anatomy, Polytechnic University of the Marche Region, inserire via, insecure CAP, Ancona, Italy. Electronic address: R.Montironi@univpm.it.
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Montironi
mesh_terms: D005260:Female; D006801:Humans; D007668:Kidney / Q000473:pathology* / Q000601:surgery; D007680:Kidney Neoplasms / Q000473:pathology* / Q000601:surgery; D008875:Middle Aged; D009392:Nephrectomy; D016896:Treatment Outcome
keywords: Partial nephrectomy; Pleomorphic Hyalinizing Angiectatic Tumor (PHAT); Renal tumor