title: Isotretinoin increased carotid intima-media thickness in acne patients.
abstract: BACKGROUND
  Isotretinoin (Iso) in acne treatment may cause dyslipidemia and increase in liver enzymes. Moreover, its effect on lipid and glucose metabolism may induce atherosclerotic complications. The aim of this study was to evaluate carotid intima-media thickness (CIMT), osteopontin (OPN), lipid, high sensitive C-reaktive protein (hs-CRP) levels, and insulin resistance (HOMA-IR) in acne patients before and after Iso treatment.
  
  
  METHODS
  Twenty-one acne patients were treated with Iso (0.5-0.8 mg/kg) for four months. Blood tests for lipid profile, fasting glucose, liver enzymes, OPN, HOMA-IR, hs-CRP and CIMT measurements were performed before and after Iso treatment. Serum levels of OPN and, hs-CRP were measured by ELISA and particle-enhanced turbidimetric immunoassay respectively.
  
  
  RESULTS
  Iso treatment significantly increased lipid levels, CIMT (0.60-0.74 mm; p ˂0.001); whereas it non-significantly increased HOMA-IR (0.91-1.87; p =0.70), OPN (4.32-5.44 ng/ml; p =0.27), and hs-CRP (0.08-0.09 mg/dl; p =0.88) levels. There was no correlation between OPN and CIMT (p =0.77).
  
  
  CONCLUSIONS
  Isotretinoin treatment for four months significantly increased CIMT in acne patients. Hippokratia 2016, 20(1): 14-18.
authors.affiliation: Department of Endocrinology and Metabolism, Medical Faculty, Sifa University, Izmir, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Saklamaz
authors.affiliation: Department of Dermatology, Medical Faculty, Sifa University, Izmir, Turkey.
authors.forename: B
authors.initials: B
authors.lastname: Uyar
authors.affiliation: Department of Internal Medicine, Medical Faculty, Sifa University, Izmir, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Yalcin
authors.affiliation: Department of Biostatistics, Medical Faculty, Sifa University, Izmir, Turkey.
authors.forename: H
authors.initials: H
authors.lastname: Cengiz
keywords: Isotretinoin; carotid intima-media thickness; homeostasis model assessment of insulin resistance; osteopontin