title: Large dose hyperpolarized water with dissolution-DNP at high magnetic field.
abstract: We demonstrate a method for the preparation of hyperpolarized water by dissolution Dynamic Nuclear Polarization at high magnetic field. Protons were polarized at 6.7T and 1.1K to >70% with frequency modulated microwave irradiation at 188GHz. 97.2±0.7% of the radical was extracted from the sample in the dissolution in a two-phase system. 16±1mL of 5.0M1H in D2O with a polarization of 13.0±0.9% in the liquid state was obtained, corresponding to an enhancement factor of 4000±300 compared to the thermal equilibrium at 9.4T and 293K. A longitudinal relaxation time constant of 16±1s was measured. The sample was polarized and dissolved in a fluid path compatible with clinical polarizers. The volume of hyperpolarized water produced by this method enables angiography and perfusion measurements in large animals, as well as NMR experiments for studies of e.g. proton exchange and polarization transfer to other nuclei.
authors.affiliation: Department of Electrical Engineering, Technical University of Denmark, Kgs. Lyngby, Denmark.
authors.forename: Kasper Wigh
authors.initials: KW
authors.lastname: Lipsø
authors.affiliation: Department of Electrical Engineering, Technical University of Denmark, Kgs. Lyngby, Denmark.
authors.forename: Sean
authors.initials: S
authors.lastname: Bowen
authors.affiliation: Department of Electrical Engineering, Technical University of Denmark, Kgs. Lyngby, Denmark.
authors.forename: Oleksandr
authors.initials: O
authors.lastname: Rybalko
authors.affiliation: Department of Electrical Engineering, Technical University of Denmark, Kgs. Lyngby, Denmark; GE Healthcare, Brøndby, Denmark. Electronic address: jhar@elektro.dtu.dk.
authors.forename: Jan Henrik
authors.initials: JH
authors.lastname: Ardenkjær-Larsen
keywords: Dissolution-DNP; Hyperpolarization; Hyperpolarized water