title: Potential for treatment and a Zika virus vaccine.
abstract: Zika virus (ZIKV) has only recently been exposed as a significant public health threat, and much of our limited knowledge of its pathogenesis and triggered immune responses were discovered in only the last few years. There are currently no ZIKV-specific therapeutics or vaccines available. This review seeks to bring the reader up-to-date with the latest developments in finding a way to combat this emerging infectious disease.
  
  
  
  Current strategies used for developing ZIKV vaccines or treatments follow proven methods used against other flaviviruses. Unfortunately, ZIKV carries many unique challenges, such as the need to target drugs and vaccines towards immunocompromised populations (pregnant mothers and fetuses), the risk of stimulating harmful immune responses (either autoimmune or antibody-dependent enhancement of infection in those with previous flavivirus exposure), frequently silent infection that may delay treatment and increase risk of transmission to others, and multiple routes of transmission (arthropod vector, sexual, bloodborne, and potentially other body fluids).
  
  
  
  Current medical recommendations are directed towards resolving symptoms and not the actual infection; however, ZIKV treatments and vaccines are in development. Vector control and travel restrictions to endemic areas may remain our only available interventions for some time.
authors.affiliation: aDepartment of Microbiology, Immunology and Molecular Genetics bMolecular Biology Interdepartmental Program, University of California, Los Angeles, California, USA cCenter of System Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing dSuzhou Institute of Systems, Suzhou, Jiangsu, China.
authors.forename: Natalie
authors.initials: N
authors.lastname: Quanquin
authors.forename: Lulan
authors.initials: L
authors.lastname: Wang
authors.forename: Genhong
authors.initials: G
authors.lastname: Cheng
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use*; D006801:Humans; D014765:Viral Vaccines; D000071243:Zika Virus Infection / Q000150:complications / Q000276:immunology / Q000628:therapy* / Q000635:transmission
chemical_list: D000998:Antiviral Agents; D014765:Viral Vaccines