title: Orange juice with a high-fat meal prolongs postprandial lipemia in apparently healthy overweight/obese women.
abstract: OBJECTIVE
  We investigated the postprandial response of lipid markers to a high-fat meal (HFM) with two different beverages in apparently healthy normal-weight and overweight/obese women.
  
  
  METHODS
  This crossover, randomized study enrolled 36 women, of whom 21 had normal weight (body mass index [BMI] 22 ± 1.8 kg/m2) and 15 had overweight/obesity (BMI 31 ± 3.7 kg/m2). In two different test days, the participants ingested a HFM (37% of energy as saturated fat) with 500 mL of water (HFM-W) or 500 mL of orange juice (HFM-OJ). Blood samples were collected at baseline (12-hour fasting), and at 2, 3, and 5 hours postprandial. The analysis included fasting and postprandial total cholesterol, HDL-c, LDL-c, triglycerides (TG), uric acid, and complement C3. Brazilian Clinical Trials Registry (ReBEC); Primary Identification Number: RBR-2h3wjn (www.ensaiosclinicos.gov.br).
  
  
  RESULTS
  TG levels increased at 3 hours with HFM-OJ in normal-weight women (p = 0.01) and returned to normal levels at 5h. TG increased at 3 hours with HFM-W (p = 0.01) and HFM-OJ (p = 0.02), and remained high at 5 hours (p = 0.03) in overweight/obese women. Complement C3 remained unchanged, but showed different responses between meals (p = 0.01 for positive incremental area under the curve [piAUC] HFM-OJ vs. HFM-W, respectively).
  
  
  CONCLUSIONS
  In apparently healthy overweight/obese women compared with normal-weight ones, the concomitant intake of orange juice with a HFM prolonged postprandial lipemia but had no effect on postprandial complement C3 concentrations.
authors.affiliation: Departamento de Nutrição e Saúde, Universidade Federal de Viçosa (UFV), Viçosa, MG, Brasil.
authors.forename: Raquel Cristina L A
authors.initials: RCLA
authors.lastname: Coelho
authors.affiliation: Departamento de Nutrição e Saúde, Universidade Federal de Viçosa (UFV), Viçosa, MG, Brasil.
authors.forename: Helen Hermana M
authors.initials: HHM
authors.lastname: Hermsdorff
authors.affiliation: Departamento de Nutrição e Saúde, Universidade Federal de Viçosa (UFV), Viçosa, MG, Brasil.
authors.forename: Renata S
authors.initials: RS
authors.lastname: Gomide
authors.affiliation: Departamento de Nutrição e Saúde, Universidade Federal de Viçosa (UFV), Viçosa, MG, Brasil.
authors.forename: Raquel Duarte M
authors.initials: RDM
authors.lastname: Alves
authors.affiliation: Departamento de Nutrição e Saúde, Universidade Federal de Viçosa (UFV), Viçosa, MG, Brasil.
authors.forename: Josefina
authors.initials: J
authors.lastname: Bressan
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D015992:Body Mass Index; D002784:Cholesterol / Q000097:blood; D032084:Citrus sinensis; D018592:Cross-Over Studies; D059305:Diet, High-Fat; D004041:Dietary Fats / Q000097:blood; D005215:Fasting; D005260:Female; D000067030:Fruit and Vegetable Juices; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood*; D050177:Overweight / Q000097:blood*; D019518:Postprandial Period / Q000502:physiology*; D012016:Reference Values; D012307:Risk Factors; D018709:Statistics, Nonparametric; D013997:Time Factors; D014280:Triglycerides / Q000097:blood; D055815:Young Adult
chemical_list: D004041:Dietary Fats; D014280:Triglycerides; D002784:Cholesterol