title: Beneficial effects of Plantago albicans on high-fat diet-induced obesity in rats.
abstract: Obesity is a one of the main global public health problems associated with chronic diseases such as coronary heart disease, diabetes and cancer. As a solution to obesity, we suggest Plantago albicans, which is a medicinal plant with several biological effects. This study assesses the possible anti-obesity protective properties of Plantago albicans in high fat diet-fed rats. 28 male Wistar rats were divided into 4 groups; a group which received normal diet (C), the second group was fed HDF diet (HDF), the third group was given normal diet supplemented with Plantago albicans (P.AL), and the fourth group received HDF supplemented with Plantago albicans (HDF+P.AL) (30mg/kg/day) for 7 weeks. Our results showed an increase in body weight of HDF rats by ∼16% as compared to the control group with an increase in the levels of total cholesterol (TC) as well as LDL-cholesterol, triglycerides (TG) in serum. Also, the concentration of TBARS increased in the liver and heart of HDF-fed rats as compared to the control group. The oral gavage of Plantago albicans extract to obese rats induced a reduction in their body weight, lipid accumulation in liver and heart tissue, compared to the high-fat diet control rats. The obtained results proved that the antioxidant potency of Plantago albicans extracts was correlated with their phenolic and flavonoid contents. The antioxidant capacity of the extract was evaluated by DPPH test (as EC50=250±2.12μg/mL) and FRAP tests (as EC50=27.77±0.14μg/mL). These results confirm the phytochemical and antioxidant impact of Plantago albicans extracts. Plantago albicans content was determined using validated HPLC methodology.
authors.affiliation: Laboratory of Environmental Physiopathology, Valorization of Bioactive Molecules and Mathematical Modeling, Faculty of Sciences of Sfax, Road Soukra km 3.5- PB n° 1171-3000, Sfax, Tunisia; Laboratory Animal Eco physiology, Faculty of sciences, Sidi Ahmed Zarrouk, 2112, Gafsa, Tunisia. Electronic address: Samout_noura@hotmail.fr.
authors.forename: Noura
authors.initials: N
authors.lastname: Samout
authors.affiliation: Laboratory of Environmental Physiopathology, Valorization of Bioactive Molecules and Mathematical Modeling, Faculty of Sciences of Sfax, Road Soukra km 3.5- PB n° 1171-3000, Sfax, Tunisia; Laboratory Animal Eco physiology, Faculty of sciences, Sidi Ahmed Zarrouk, 2112, Gafsa, Tunisia.
authors.forename: Amani
authors.initials: A
authors.lastname: Ettaya
authors.affiliation: Laboratory of Environmental Physiopathology, Valorization of Bioactive Molecules and Mathematical Modeling, Faculty of Sciences of Sfax, Road Soukra km 3.5- PB n° 1171-3000, Sfax, Tunisia; Laboratory Animal Eco physiology, Faculty of sciences, Sidi Ahmed Zarrouk, 2112, Gafsa, Tunisia.
authors.forename: Hafsia
authors.initials: H
authors.lastname: Bouzenna
authors.affiliation: Unity of Commun Services, Faculty of sciences, Sidi Ahmed Zarrouk, 2112, Gafsa, Tunisia.
authors.forename: Sana
authors.initials: S
authors.lastname: Ncib
authors.affiliation: Laboratory of Environmental Physiopathology, Valorization of Bioactive Molecules and Mathematical Modeling, Faculty of Sciences of Sfax, Road Soukra km 3.5- PB n° 1171-3000, Sfax, Tunisia.
authors.forename: Abdelfattah
authors.initials: A
authors.lastname: Elfeki
authors.affiliation: Laboratory of Environmental Physiopathology, Valorization of Bioactive Molecules and Mathematical Modeling, Faculty of Sciences of Sfax, Road Soukra km 3.5- PB n° 1171-3000, Sfax, Tunisia; Laboratory Animal Eco physiology, Faculty of sciences, Sidi Ahmed Zarrouk, 2112, Gafsa, Tunisia.
authors.forename: Najla
authors.initials: N
authors.lastname: Hfaiedh
mesh_terms: D000818:Animals; D019440:Anti-Obesity Agents / Q000302:isolation & purification / Q000494:pharmacology*; D000975:Antioxidants / Q000302:isolation & purification / Q000494:pharmacology*; D015415:Biomarkers / Q000097:blood; D001713:Biphenyl Compounds / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D059305:Diet, High-Fat; D004195:Disease Models, Animal; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology; D036681:Fluorescence Recovery After Photobleaching; D008055:Lipids / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008297:Male; D009206:Myocardium / Q000378:metabolism; D009765:Obesity / Q000097:blood / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D010636:Phenols / Q000302:isolation & purification / Q000494:pharmacology; D008517:Phytotherapy; D010851:Picrates / Q000737:chemistry; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D018515:Plant Leaves; D010943:Plantago / Q000737:chemistry; D010946:Plants, Medicinal; D017208:Rats, Wistar; D015430:Weight Gain / Q000187:drug effects*
chemical_list: D019440:Anti-Obesity Agents; D000975:Antioxidants; D015415:Biomarkers; D001713:Biphenyl Compounds; D005419:Flavonoids; D008055:Lipids; D010636:Phenols; D010851:Picrates; D010936:Plant Extracts; C004931:1,1-diphenyl-2-picrylhydrazyl
keywords: Heart; Liver; Obesity; Oxidative stress; Plantago albicans