title: Sumoylation Stabilizes Smoothened to Promote Hedgehog Signaling.
abstract: The conserved Hedgehog signaling pathway is essential for embryonic development and tissue homeostasis and is tightly regulated. In this issue of Developmental Cell, Ma et al. (2016) demonstrate that sumoylation works in parallel with phosphorylation to stabilize Smoothened, antagonizing its ubiquitination and subsequent degradation, thus activating Hh target gene transcription.
authors.affiliation: State Key Laboratory of Genetic Engineering, Institute of Genetics, Collaborative Innovation Center of Genetics and Development, School of Life Sciences, Fudan University, Shanghai 200438, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Qi
authors.affiliation: State Key Laboratory of Genetic Engineering, Institute of Genetics, Collaborative Innovation Center of Genetics and Development, School of Life Sciences, Fudan University, Shanghai 200438, China.
authors.forename: Han
authors.initials: H
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Genetic Engineering, Institute of Genetics, Collaborative Innovation Center of Genetics and Development, School of Life Sciences, Fudan University, Shanghai 200438, China; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA. Electronic address: xlin@fudan.edu.cn.
authors.forename: Xinhua
authors.initials: X
authors.lastname: Lin
mesh_terms: D053823:Hedgehog Proteins / Q000235:genetics*; D043562:Receptors, G-Protein-Coupled / Q000235:genetics; D015398:Signal Transduction; D058207:Sumoylation; D054875:Ubiquitination
chemical_list: D053823:Hedgehog Proteins; D043562:Receptors, G-Protein-Coupled