title: The Association between VDR Gene Polymorphisms and Diabetic Retinopathy Susceptibility: A Systematic Review and Meta-Analysis.
abstract: Aims. Studies on the associations of vitamin D receptor (VDR) gene polymorphisms with diabetic retinopathy (DR) susceptibility reported conflicting results. A systematic meta-analysis was undertaken to clarify this topic.Methods. A systematic search of electronic databases (PubMed, EMBASE, and CNKI) was carried out until March 31, 2016. The pooled odds ratio (OR) and 95% confidence interval (CI) were used to assess the strength of the association.Results. A total of 7 studies fulfilling the inclusion criteria were included in this meta-analysis (649 cases and 707 controls). Pooled ORs showed a significant association between FokI polymorphism and DR risk in all the four genetic models (OR = 1.612 (1.354~1.921), 1.988 (1.481~2.668), 1.889 (1.424~2.505), and 2.674 (1.493~4.790) in allelic, dominant, recessive, and additive models, resp.,PZ< 0.01), but not for TaqI or BsmI polymorphism (PZ> 0.05). Similar results were found in the subgroup analysis. Sensitivity analysis indicated that the results were relatively stable and reliable. Results of Begg's and Egger's tests suggested a lack of publication bias.Conclusions. Our meta-analysis demonstrated that DR was significantly associated with VDR gene FokI polymorphism. However, due to the relatively small sample size in this meta-analysis, further studies with a larger sample size should be done to confirm the findings.
authors.affiliation: Department of Endocrinology, Henan Provincial People's Hospital and Zhengzhou University People's Hospital, Zhengzhou, Henan, China.
authors.forename: Yun
authors.identifier: 0000-0001-7526-5714
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Endocrinology, Henan Provincial People's Hospital and Zhengzhou University People's Hospital, Zhengzhou, Henan, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Xia
authors.affiliation: Department of Endocrinology, Henan Provincial People's Hospital and Zhengzhou University People's Hospital, Zhengzhou, Henan, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Lu
authors.affiliation: Department of Endocrinology, Henan Provincial People's Hospital and Zhengzhou University People's Hospital, Zhengzhou, Henan, China.
authors.forename: Huijuan
authors.identifier: 0000-0002-0486-0994
authors.initials: H
authors.lastname: Yuan
mesh_terms: D003930:Diabetic Retinopathy; D020022:Genetic Predisposition to Disease; D006801:Humans; D011110:Polymorphism, Genetic / Q000235:genetics*; D018167:Receptors, Calcitriol / Q000235:genetics*
chemical_list: D018167:Receptors, Calcitriol