title: A cross-sectional study of the association between adipokine levels and bone mineral density according to obesity and menopausal status in Korean women.
abstract: Results regarding the association between adipokine levels and bone mineral density (BMD) have been inconsistent; the effects of sex, menopause, and central obesity remain unknown. We evaluated the association between serum leptin, adiponectin, and high-molecular-weight (HMW) adiponectin levels and BMD according to menopause and central obesity status in Korean women. This cross-sectional study comprised 255 women undergoing examinations at the CHA Bundang Medical Center. Participants were divided according to menopause, and central obesity status. We measured serum adipokine levels and BMD using an enzyme-linked immunosorbent assay and dual-energy X-ray absorptiometry, respectively. After adjusting for age, body mass index, alkaline phosphatase levels and the Homeostasis Model Assessment index, leptin levels were negatively associated with non-vertebral BMD (total hip, β = -0.576, P = 0.006; femoral neck, β = -0.608, P = 0.007) in postmenopausal women without central obesity. Among women without central obesity, HMW adiponectin levels were positively associated with total hip BMD (β = 0.240, P = 0.010) in premenopausal women but negatively associated with BMD (lumbar, β = -0.436, P = 0.012; femoral neck, β = -0.468, P = 0.007) in postmenopausal women. Thus, the association between adipokine levels and BMD varies according to the menopause and central obesity status.
authors.affiliation: Department of Family Medicine, CHA Bundang Medical Center, CHA University, 59 Yatap-ro, Bundang-gu, Seongnam-si, Gyeonggi-do, 13496, Republic of Korea.
authors.forename: Ji-Hee
authors.initials: JH
authors.lastname: Haam
authors.affiliation: Department of Family Medicine, CHA Bundang Medical Center, CHA University, 59 Yatap-ro, Bundang-gu, Seongnam-si, Gyeonggi-do, 13496, Republic of Korea.
authors.forename: Young-Sang
authors.initials: YS
authors.lastname: Kim
authors.affiliation: Department of Family Medicine, CHA Bundang Medical Center, CHA University, 59 Yatap-ro, Bundang-gu, Seongnam-si, Gyeonggi-do, 13496, Republic of Korea. mjkimfm@cha.ac.kr.
authors.forename: Moon Jong
authors.initials: MJ
authors.lastname: Kim
authors.affiliation: Department of Family Medicine, Dongguk University Bundang Oriental Hospital, Seongnam, 13601, Republic of Korea.
authors.forename: Hyung Suk
authors.initials: HS
authors.lastname: Koo
authors.affiliation: Department of Family Medicine, CHA Bundang Medical Center, CHA University, 59 Yatap-ro, Bundang-gu, Seongnam-si, Gyeonggi-do, 13496, Republic of Korea.
authors.forename: Hyung Yuk
authors.initials: HY
authors.lastname: Kim
authors.affiliation: Department of Family Medicine, CHA Bundang Medical Center, CHA University, 59 Yatap-ro, Bundang-gu, Seongnam-si, Gyeonggi-do, 13496, Republic of Korea.
authors.forename: Hye-Jung
authors.initials: HJ
authors.lastname: Kim
authors.affiliation: Department of Family Medicine, CHA Bundang Medical Center, CHA University, 59 Yatap-ro, Bundang-gu, Seongnam-si, Gyeonggi-do, 13496, Republic of Korea.
authors.forename: Ki Hyun
authors.initials: KH
authors.lastname: Park
authors.affiliation: Department of Family Practice and Community Health, Ajou University, School of Medicine, Suwon, 16499, Republic of Korea.
authors.forename: Nam-Seok
authors.initials: NS
authors.lastname: Joo
authors.affiliation: Department of Family Medicine, CHA Bundang Medical Center, CHA University, 59 Yatap-ro, Bundang-gu, Seongnam-si, Gyeonggi-do, 13496, Republic of Korea.
authors.forename: Kyung-Chae
authors.initials: KC
authors.lastname: Park
mesh_terms: D015502:Absorptiometry, Photon; D054392:Adipokines / Q000097:blood*; D052242:Adiponectin / Q000097:blood; D000328:Adult; D015992:Body Mass Index; D015519:Bone Density; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood; D008593:Menopause / Q000097:blood*; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000503:physiopathology*; D017698:Postmenopause / Q000097:blood; D017697:Premenopause; D012044:Regression Analysis; D056910:Republic of Korea
chemical_list: C499918:ADIPOQ protein, human; D054392:Adipokines; D052242:Adiponectin; D020738:Leptin
keywords: Adipokine; Bone mineral density; High-molecular-weight adiponectin; Leptin