title: [Diseases of connective tissue in IgG4-associated autoimmune diseases].
abstract: The IgG4-associated diseases of connective tissue are caused by allergen-mediated autoimmune processes. The retroperitoneum, mesentery and mediastinum as well as other less common localizations, such as the neck, orbit and periarticular connective tissue can be affected. Inflammatory fibrosis is initially dominated by a lymphocytic and plasma cell-rich infiltrate and later by cell-poor storiform fibrosis. Stenosis and occlusion of vessels, ureters and intestines can cause severe complications. Computed tomography (CT) and magnetic resonance imaging (MRI) can be implemented in the diagnostic algorithm to narrow the differential diagnosis, delineate the distribution of fibrosis and reveal complications.
authors.affiliation: Klinik für Diagnostische und Interventionelle Radiologie, Justus-Liebig-Universität Giessen, Klinikstrasse 33, 35392, Giessen, Deutschland. gabriele.krombach@uniklinikum-giessen.de.
authors.forename: G A
authors.initials: GA
authors.lastname: Krombach
mesh_terms: D001327:Autoimmune Diseases / Q000000981:diagnostic imaging* / Q000276:immunology / Q000473:pathology; D003240:Connective Tissue Diseases / Q000000981:diagnostic imaging* / Q000276:immunology / Q000473:pathology; D003937:Diagnosis, Differential; D019317:Evidence-Based Medicine; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D007074:Immunoglobulin G
keywords: IgG4 related diseases of connective tissue; IgG4-related fibrosis; Retroperitoneal fibrosis; Sclerosing mediastinitis; Sclerosing mesenteritis