title: The High Frequency of PIK3CA Mutations in Iranian Breast Cancer Patients.
abstract: In breast cancer, somatic mutations of PIK3CA oncogene are common. We investigated the mutational status of exons 9 and 20 of the PIK3CA gene by polymerase chain reaction and direct sequencing in 80 breast tumors, and observed that 45% of these contained PIK3CA mutations in the mentioned exons. These mutations were found more in progesterone receptor positive and Her2- tumors, but this association did not reach a statistically significant level. Also, we observed a significant association between PIK3CA mutations and low-grade tumors. In our study, PIK3CA mutations were related to good and moderate prognosis in breast cancer patients.
authors.affiliation: a Medical Genetics Department , Medical School, Tehran University of Medical Sciences , Tehran , Iran.
authors.forename: Ghasem
authors.initials: G
authors.lastname: Azizi Tabesh
authors.affiliation: a Medical Genetics Department , Medical School, Tehran University of Medical Sciences , Tehran , Iran.
authors.forename: Pantea
authors.initials: P
authors.lastname: Izadi
authors.affiliation: b Iran National Tumor Bank , Cancer Institute, Tehran University of Medical Sciences , Tehran , Iran.
authors.forename: Forouzandeh
authors.initials: F
authors.lastname: Fereidooni
authors.affiliation: b Iran National Tumor Bank , Cancer Institute, Tehran University of Medical Sciences , Tehran , Iran.
authors.forename: Amir Nader
authors.initials: AN
authors.lastname: Emami Razavi
authors.affiliation: a Medical Genetics Department , Medical School, Tehran University of Medical Sciences , Tehran , Iran.
authors.forename: Javad
authors.initials: J
authors.lastname: Tavakkoly Bazzaz
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology*; D058534:Class I Phosphatidylinositol 3-Kinases; D005091:Exons; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007492:Iran; D009154:Mutation; D060787:Neoplasm Grading; D019869:Phosphatidylinositol 3-Kinases / Q000235:genetics*; D016133:Polymerase Chain Reaction / Q000379:methods; D011379:Prognosis; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000235:genetics; D011980:Receptors, Progesterone / Q000235:genetics; D017422:Sequence Analysis, DNA / Q000379:methods; D044465:White People / Q000235:genetics*
chemical_list: D058534:Class I Phosphatidylinositol 3-Kinases; D019869:Phosphatidylinositol 3-Kinases; D018719:Erb-b2 Receptor Tyrosine Kinases; D011980:Receptors, Progesterone; C484760:PIK3CA protein, human; C508053:ERBB2 protein, human
keywords: Breast cancer; PIK3CA; somatic mutation