title: Black hairy tongue after chemotherapy for malignant brain tumors.
abstract: Black hairy tongue (BHT) developed in five patients (2.6%) among 192 patients undergoing chemotherapy for malignant brain tumors. Three patients with a history of diabetes mellitus developed BHT within 10 days after the initiation of chemotherapy. The other two patients suffered more than 100 days after induction and lymphopenia of grade 3 or worse developed for more than 20 days, which was not observed in the three patients with diabetes. We found that BHT could develop after chemotherapy for malignant brain tumors. Patients with diabetes mellitus presented early after chemotherapy, while patients with longstanding severe lymphopenia presented in late phase.
authors.affiliation: Department of Neurosurgery, Kyorin University Faculty of Medicine, 6-20-2 Shinkawa, Mitaka-City, Tokyo, 181-8611, Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Yamagishi
authors.affiliation: Department of Neurosurgery, Kyorin University Faculty of Medicine, 6-20-2 Shinkawa, Mitaka-City, Tokyo, 181-8611, Japan. kskmaru-tky@umin.ac.jp.
authors.forename: Keisuke
authors.initials: K
authors.lastname: Maruyama
authors.affiliation: Department of Neurosurgery, Kyorin University Faculty of Medicine, 6-20-2 Shinkawa, Mitaka-City, Tokyo, 181-8611, Japan.
authors.forename: Keiichi
authors.initials: K
authors.lastname: Kobayashi
authors.affiliation: Department of Neurosurgery, Kyorin University Faculty of Medicine, 6-20-2 Shinkawa, Mitaka-City, Tokyo, 181-8611, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kume
authors.affiliation: Department of Neurosurgery, Kyorin University Faculty of Medicine, 6-20-2 Shinkawa, Mitaka-City, Tokyo, 181-8611, Japan.
authors.forename: Nobuyoshi
authors.initials: N
authors.lastname: Sasaki
authors.affiliation: Department of Neurosurgery, Kyorin University Faculty of Medicine, 6-20-2 Shinkawa, Mitaka-City, Tokyo, 181-8611, Japan.
authors.forename: Shigeomi
authors.initials: S
authors.lastname: Yokoya
authors.affiliation: Department of Neurosurgery, Kyorin University Faculty of Medicine, 6-20-2 Shinkawa, Mitaka-City, Tokyo, 181-8611, Japan.
authors.forename: Kuniaki
authors.initials: K
authors.lastname: Saito
authors.affiliation: Department of Neurosurgery, Kyorin University Faculty of Medicine, 6-20-2 Shinkawa, Mitaka-City, Tokyo, 181-8611, Japan.
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Shiokawa
authors.affiliation: Department of Neurosurgery, Kyorin University Faculty of Medicine, 6-20-2 Shinkawa, Mitaka-City, Tokyo, 181-8611, Japan.
authors.forename: Motoo
authors.initials: M
authors.lastname: Nagane
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects*; D001932:Brain Neoplasms / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D014064:Tongue, Hairy / Q000139:chemically induced*
chemical_list: D000970:Antineoplastic Agents
keywords: Black hairy tongue; Chemotherapy; Glioblastoma; Primary central nervous system lymphoma