title: Using an Implementation Research Framework to Identify Potential Facilitators and Barriers of an Intervention to Increase HPV Vaccine Uptake.
abstract: Although the incidence of cervical cancer has been decreasing in the United States over the last decade, Hispanic and African American women have substantially higher rates than Caucasian women. The human papillomavirus (HPV) is a necessary, although insufficient, cause of cervical cancer. In the United States in 2013, only 37.6% of girls 13 to 17 years of age received the recommended 3 doses of a vaccine that is almost 100% efficacious for preventing infection with viruses that are responsible for 70% of cervical cancers. Implementation research has been underutilized in interventions for increasing vaccine uptake. The Consolidated Framework for Implementation Research (CFIR), an approach for designing effective implementation strategies, integrates 5 domains that may include barriers and facilitators of HPV vaccination. These include the innovative practice (Intervention), communities where youth and parents live (Outer Setting), agencies offering vaccination (Inner Setting), health care staff (Providers), and planned execution and evaluation of intervention delivery (Implementation Process).
  
  
  
  Secondary qualitative analysis of transcripts of interviews with 30 community health care providers was conducted using the CFIR to code potential barriers and facilitators of HPV vaccination implementation.
  
  
  
  All CFIR domains except Implementation Process were well represented in providers' statements about challenges and supports for HPV vaccination.
  
  
  
  A comprehensive implementation framework for promoting HPV vaccination may increase vaccination rates in ethnically diverse communities. This study suggests that the CFIR can be used to guide clinicians in planning implementation of new approaches to increasing HPV vaccine uptake in their settings. Further research is needed to determine whether identifying implementation barriers and facilitators in all 5 CFIR domains as part of developing an intervention contributes to improved HPV vaccination rates.
authors.affiliation: Tennessee State University, Center for Prevention Research, Nashville, Tennessee (Dr Selove and Ms Foster); Meharry Medical College, Family and Community Medicine, Nashville, Tennessee (Ms Mack and Dr Sanderson); Vanderbilt University School of Medicine, Division of Epidemiology, Department of Medicine, Nashville, Tennessee (Dr Hull).
authors.forename: Rebecca
authors.initials: R
authors.lastname: Selove
authors.forename: Maya
authors.initials: M
authors.lastname: Foster
authors.forename: Raquel
authors.initials: R
authors.lastname: Mack
authors.forename: Maureen
authors.initials: M
authors.lastname: Sanderson
authors.forename: Pamela C
authors.initials: PC
authors.lastname: Hull
mesh_terms: D000328:Adult; D005260:Female; D007722:Health Knowledge, Attitudes, Practice; D006282:Health Personnel / Q000523:psychology* / Q000706:statistics & numerical data; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D030361:Papillomavirus Infections / Q000150:complications / Q000453:epidemiology; D053918:Papillomavirus Vaccines / Q000008:administration & dosage* / Q000627:therapeutic use; D010342:Patient Acceptance of Health Care / Q000208:ethnology / Q000523:psychology / Q000706:statistics & numerical data; D036301:Qualitative Research; D044469:Racial Groups / Q000706:statistics & numerical data; D013714:Tennessee; D014481:United States / Q000453:epidemiology; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology / Q000517:prevention & control; D014611:Vaccination / Q000379:methods* / Q000592:standards / Q000706:statistics & numerical data
chemical_list: D053918:Papillomavirus Vaccines