title: Screening on binary Ti alloy with excellent mechanical property and castability for dental prosthesis application.
abstract: In the present study, the microstructure, mechanical property, castability, corrosion behavior and in vitro cytocompatibility of binary Ti-2X alloys with various alloying elements, including Ag, Bi, Ga, Ge, Hf, In, Mo, Nb, Sn and Zr, were systematically investigated, in order to assess their potential applications in dental field. The experimental results showed that all binary Ti‒2X alloys consisted entirely α-Ti phase. The tensile strength and microhardness of Ti were improved by adding alloying elements. The castability of Ti was significantly improved by separately adding 2 wt.% Bi, Ga, Hf, Mo, Nb, Sn and Zr. The corrosion resistance of Ti in both normal artificial saliva solution (AS) and extreme artificial saliva solution (ASFL, AS with 0.2 wt.% NaF and 0.3 wt.% lactic acid) has been improved by separately adding alloying elements. In addition, the extracts of studied Ti‒2X alloys produced no significant deleterious effect to both fibroblasts L929 cells and osteoblast-like MG63 cells, indicating a good in vitro cytocompatibility, at the same level as pure Ti. The combination of enhanced mechanical properties, castability, corrosion behavior, and in vitro cytocompatibility make the developed Ti‒2X alloys have great potential for future stomatological applications.
authors.affiliation: Department of Materials Science and Engineering, College of Engineering, Peking University, Beijing 100871, China.|Musculoskeletal Research Laboratory, Department of Orthopaedics &Traumatology, The Chinese University of Hong Kong, Shatin, Hong Kong, China.
authors.forename: H F
authors.initials: HF
authors.lastname: Li
authors.affiliation: Center for Biomedical Materials and Engineering, Harbin Engineering University, Harbin 150001, China.
authors.forename: K J
authors.initials: KJ
authors.lastname: Qiu
authors.affiliation: Department of Materials Science and Engineering, College of Engineering, Peking University, Beijing 100871, China.
authors.forename: W
authors.initials: W
authors.lastname: Yuan
authors.affiliation: Center for Biomedical Materials and Engineering, Harbin Engineering University, Harbin 150001, China.
authors.forename: F Y
authors.initials: FY
authors.lastname: Zhou
authors.affiliation: Center for Biomedical Materials and Engineering, Harbin Engineering University, Harbin 150001, China.
authors.forename: B L
authors.initials: BL
authors.lastname: Wang
authors.affiliation: Center for Biomedical Materials and Engineering, Harbin Engineering University, Harbin 150001, China.
authors.forename: L
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Materials Science and Engineering, College of Engineering, Peking University, Beijing 100871, China.|Center for Biomedical Materials and Engineering, Harbin Engineering University, Harbin 150001, China.
authors.forename: Y F
authors.initials: YF
authors.lastname: Zheng
authors.affiliation: General Dental Department, School of Stomatology, Peking University, Beijing 100081, China.
authors.forename: Y H
authors.initials: YH
authors.lastname: Liu
mesh_terms: D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D003343:Corrosion; D003722:Dental Alloys / Q000494:pharmacology*; D003735:Dental Casting Technique; D017266:Dental Prosthesis; D004563:Electrochemistry; D006244:Hardness; D006801:Humans; D008422:Materials Testing / Q000379:methods*; D055595:Mechanical Phenomena; D051379:Mice; D013718:Tensile Strength; D014025:Titanium / Q000494:pharmacology*; D014961:X-Ray Diffraction
chemical_list: D003722:Dental Alloys; D014025:Titanium; D000469:Alkaline Phosphatase