title: New dinitrosyl iron complexes bound with physiologically active dipeptide carnosine.
abstract: Dinitrosyl iron complexes (DNICs) are physiological NO derivatives and account for many NO functions in biology. Polyfunctional dipeptide carnosine (beta-alanyl-L-histidine) is considered to be a very promising pharmacological agent. It was shown that in the system containing carnosine, iron ions and Angeli's salt, a new type of DNICs bound with carnosine as ligand {(carnosine)2-Fe-(NO)2}, was formed. We studied how the carbonyl compound methylglyoxal influenced this process. Carnosine-bound DNICs appear to be one of the cell's adaptation mechanisms when the amount of reactive carbonyl compounds increases at hyperglycemia. These complexes can also participate in signal and regulatory ways of NO and can act as protectors at oxidative and carbonyl stress conditions.
authors.affiliation: Bach Institute of Biochemistry, Research Center of Biotechnology of the Russian Academy of Sciences, Leninsky Prospect 33, Moscow, 119071, Russian Federation.
authors.forename: Konstantin B
authors.initials: KB
authors.lastname: Shumaev
authors.affiliation: Bach Institute of Biochemistry, Research Center of Biotechnology of the Russian Academy of Sciences, Leninsky Prospect 33, Moscow, 119071, Russian Federation.
authors.forename: Olga V
authors.initials: OV
authors.lastname: Kosmachevskaya
authors.affiliation: Bach Institute of Biochemistry, Research Center of Biotechnology of the Russian Academy of Sciences, Leninsky Prospect 33, Moscow, 119071, Russian Federation.
authors.forename: Elvira I
authors.initials: EI
authors.lastname: Nasybullina
authors.affiliation: National University of Science and Technology MISiS, Moscow, 119049, Russian Federation.
authors.forename: Sergey V
authors.initials: SV
authors.lastname: Gromov
authors.affiliation: National University of Science and Technology MISiS, Moscow, 119049, Russian Federation.
authors.forename: Alexander A
authors.initials: AA
authors.lastname: Novikov
authors.affiliation: Bach Institute of Biochemistry, Research Center of Biotechnology of the Russian Academy of Sciences, Leninsky Prospect 33, Moscow, 119071, Russian Federation. aftopunov@yandex.ru.
authors.forename: Alexey F
authors.initials: AF
authors.lastname: Topunov
mesh_terms: D002336:Carnosine / Q000378:metabolism*; D007501:Iron / Q000737:chemistry / Q000378:metabolism*; D009589:Nitrogen Oxides / Q000737:chemistry / Q000378:metabolism*; D011485:Protein Binding / Q000187:drug effects; D011765:Pyruvaldehyde / Q000494:pharmacology
chemical_list: D009589:Nitrogen Oxides; C073661:dinitrosyl iron complex; D011765:Pyruvaldehyde; D002336:Carnosine; D007501:Iron
keywords: Carnosine; Dinitrosyl iron complexes; Histidine; Methylglyoxal; Nitroxyl