title: Locally Recurrent Disease Related to Anal Canal Cancers.
abstract: Surgery for anal cancer is usually reserved for patients with persistent disease or local recurrence after definitive chemoradiation therapy. Patients with local recurrence should be re-evaluated for evidence of metastatic disease using positron emission tomography-computed tomography, and the local anatomy should be delineated with MRI. Eligible patients should undergo tailored surgery with the aim of achieving an R0 resection. Management is best undertaken within a specialized multidisciplinary setting. Careful patient selection and shared decision making are paramount for achieving acceptable patient-centered outcomes.
authors.affiliation: Division of Surgery, Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, 1400 Pressler Street, P.O. Box 301402, Houston, TX 77230-1402, USA.
authors.forename: Tarik
authors.initials: T
authors.lastname: Sammour
authors.affiliation: Division of Surgery, Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, 1400 Pressler Street, P.O. Box 301402, Houston, TX 77230-1402, USA.
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Rodriguez-Bigas
authors.affiliation: Division of Surgery, Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, 1400 Pressler Street, P.O. Box 301402, Houston, TX 77230-1402, USA. Electronic address: jskibber@mdanderson.org.
authors.forename: John M
authors.initials: JM
authors.lastname: Skibber
mesh_terms: D001003:Anal Canal; D001005:Anus Neoplasms / Q000473:pathology / Q000628:therapy*; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging* / Q000473:pathology / Q000628:therapy*; D059248:Chemoradiotherapy; D003131:Combined Modality Therapy; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging* / Q000473:pathology / Q000628:therapy*; D000072078:Positron Emission Tomography Computed Tomography; D012189:Retrospective Studies
keywords: Anal canal; Anal cancer; Anal squamous cell carcinoma; Exenteration; Local recurrence