title: Radical-promoted site-specific cross dehydrogenative coupling of heterocycles with nitriles.
abstract: A first free-radical triggered site-specific cross dehydrogenative coupling reaction of heterocycles with simple nitriles is developed. It allows efficient and facile access to various C-2 cyanoalkylated furans, thiophenes, indoles, and pyrroles. The extremely high selectivities in this case indicate that functionalization of an inert C-H bond could be well-controlled by radical initiation.
authors.affiliation: School of Petrochemical Engineering, Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology, Changzhou University, Changzhou 213164, P. R. China. liuzhq@lzu.edu.cn and State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P. R. China.
authors.forename: Zhong-Quan
authors.initials: ZQ
authors.lastname: Liu
authors.affiliation: College of Chemistry & Environmental Science, Hebei University, Baoding, Hebei 071002, P. R. China.
authors.forename: Zejiang
authors.initials: Z
authors.lastname: Li