title: BMP-2-loaded silica nanotube fibrous meshes for bone generation.
abstract: Silica nanotube fibrous meshes were fabricated as multiple functional matrices for both delivering bone morphological protein-2 (BMP-2) and supporting osteoblast attachment and proliferation. The meshes were fabricated via a collagen-templated sol-gel route and consisted of tubular silica with open ends. BMP-2 was loaded to the meshes by soaking in BMP-2 solution. The meshes effectively enabled the attachment and proliferation of osteoblast MC3T3-E1 cells and delivered bioactive BMP-2 to stimulate cell differentiation. These results demonstrate the potential use of the meshes in bone generation applications.
authors.affiliation: Biomaterials Unit, National Institute for Materials Science, Sengen, Tsukuba, Ibaraki 305-0047, Japan.
authors.forename: Song
authors.initials: S
authors.lastname: Chen
authors.affiliation: WPI Advanced Institute for Materials Research, Tohoku University, 2-1-1 Katahira, Aobaku, Sendai, Miyagi 980-8577, Japan.
authors.forename: Xuetao
authors.initials: X
authors.lastname: Shi
authors.affiliation: Nanotechnology Innovation Station, National Institute for Materials Science, 1-2-1 Sengen, Tsukuba, Ibaraki 305-0047, Japan.
authors.forename: Hiromi
authors.initials: H
authors.lastname: Morita
authors.affiliation: Nanotechnology Innovation Station, National Institute for Materials Science, 1-2-1 Sengen, Tsukuba, Ibaraki 305-0047, Japan.
authors.forename: Jie
authors.initials: J
authors.lastname: Li
authors.affiliation: Biomaterials Unit, National Institute for Materials Science, Sengen, Tsukuba, Ibaraki 305-0047, Japan.
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Ogawa
authors.affiliation: Department of Metallurgy and Ceramics Science, Tokyo Institute of Technology, Meguro-ku, Tokyo 152-8550, Japan.
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Ikoma
authors.affiliation: Graduate School of Natural Science and Technology, Okayama University, Tsushima, Kita-ku, Okayama 700-8530, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Hayakawa
authors.affiliation: Graduate School of Natural Science and Technology, Okayama University, Tsushima, Kita-ku, Okayama 700-8530, Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Shirosaki
authors.affiliation: Graduate School of Natural Science and Technology, Okayama University, Tsushima, Kita-ku, Okayama 700-8530, Japan.
authors.forename: Akiyoshi
authors.initials: A
authors.lastname: Osaka
authors.affiliation: Biomaterials Unit, National Institute for Materials Science, Sengen, Tsukuba, Ibaraki 305-0047, Japan; Nanotechnology Innovation Station, National Institute for Materials Science, 1-2-1 Sengen, Tsukuba, Ibaraki 305-0047, Japan.
authors.forename: Nobutaka
authors.initials: N
authors.lastname: Hanagata
keywords: bone; bone morphological protein-2 (BMP-2); osteoblasts; silica nanotube