title: Retrospective Evaluation of Whole Body Computed Tomography for Tumor Staging in Dogs with Primary Appendicular Osteosarcoma.
abstract: OBJECTIVE
  To evaluate whole body computed tomography (CT) for staging canine appendicular osteosarcoma.
  
  
  METHODS
  Retrospective case series.
  
  
  METHODS
  Client-owned dogs diagnosed with appendicular osteosarcoma (n=39).
  
  
  METHODS
  Medical records for client-owned dogs diagnosed with appendicular osteosarcoma from August 2008 to July 2014 were reviewed. Dogs were included if they had a confirmed diagnosis of appendicular osteosarcoma and were staged using whole body CT. Data collected included signalment, body weight, primary tumor location, serum alkaline phosphatase (ALP) activity, findings on 3-view thoracic radiographs, cytologic or histologic results, and findings on CT.
  
  
  RESULTS
  Thirty-nine dogs (median age 8.5 years; median body weight 37 kg) had osteosarcoma of the distal radius (n=17), proximal humerus (11) and other sites. Serum ALP activity was elevated in 14 dogs. Bone metastasis was not detected in any dog on whole body CT. Pulmonary metastasis was considered definitive on CT based on board certified radiologist assessment in 2/39 dogs (5%). Two additional dogs (2/39, 5%) had soft tissue masses diagnosed on CT, consistent with concurrent, non-metastatic malignancies.
  
  
  CONCLUSIONS
  Bone metastases were not identified in any dog with whole body CT. Thoracic and abdominal CT detected lung lesions and concurrent neoplasia in dogs with primary appendicular osteosarcoma. Whole body CT may be a useful adjunct to other screening tests for disseminated malignancy.
authors.affiliation: Department of Small Animal Clinical Sciences, University of Florida, Gainesville, Florida.
authors.forename: Jessica L
authors.initials: JL
authors.lastname: Talbott
authors.affiliation: Department of Small Animal Clinical Sciences, University of Florida, Gainesville, Florida.
authors.forename: Sarah E
authors.initials: SE
authors.lastname: Boston
authors.affiliation: Department of Small Animal Clinical Sciences, University of Florida, Gainesville, Florida.
authors.forename: Rowan J
authors.initials: RJ
authors.lastname: Milner
authors.affiliation: Department of Small Animal Clinical Sciences, University of Florida, Gainesville, Florida.
authors.forename: Amandine
authors.initials: A
authors.lastname: Lejeune
authors.affiliation: Department of Small Animal Clinical Sciences, University of Florida, Gainesville, Florida.
authors.forename: Carlos H de M
authors.initials: CH
authors.lastname: Souza
authors.affiliation: University of Surrey School of Veterinary Medicine, Surrey, United Kingdom.
authors.forename: Kelvin
authors.initials: K
authors.lastname: Kow
authors.affiliation: University of Surrey School of Veterinary Medicine, Surrey, United Kingdom.
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Bacon
authors.affiliation: Department of Large Animal Clinical Sciences, University of Florida, Gainesville, Florida.
authors.forename: Jorge A
authors.initials: JA
authors.lastname: Hernandez
mesh_terms: D000818:Animals; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000662:veterinary*; D004283:Dog Diseases / Q000000981:diagnostic imaging* / Q000473:pathology; D004285:Dogs; D005121:Extremities / Q000000981:diagnostic imaging; D005260:Female; D008297:Male; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging / Q000662:veterinary; D012516:Osteosarcoma / Q000000981:diagnostic imaging / Q000556:secondary / Q000662:veterinary*; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed / Q000662:veterinary; D051598:Whole Body Imaging / Q000662:veterinary