title: Determination of functional prognosis in hospitalized patients following an intensive care admission.
abstract: OBJECTIVE
  To investigate the factors associated with the functional progress of hospitalized patients following an intensive care admission.
  
  
  METHODS
  Retrospective study including data from a cohort of 198 hospitalized patients following an intensive care admission and not requiring mechanical ventilation in a single tertiary referral hospital. A generalized linear model was used to identify the main effects of clinical and demographic variables on the outcomes of functionality (KATZ Index of Independence in Activities of Daily Living) and muscle strength (MRC Scale). The covariates identified as independent predictors were analysed using the receiver operating characteristic curves. The analysis differentiated the periods in the intensive care unit (ICU), in the Ward (WARD) and the total time of hospital stay (TOT).
  
  
  RESULTS
  Considering the functional outcome (ΔKATZ), the variables that significantly contributed to the model (P< 0.05) were the KATZ and MRC on admission, age, sepsis (no), and total length of stay (TLS). Regarding the muscle strength outcome model (ΔMRC), the predictors were MRC on admission, Simplified Acute Physiology Score III, previous stroke, TLS, and sex (female). The variable age (AUC = 0.664) discriminated the ΔKATZICU. The variables age (AUC = 0.712), KATZ in ICU (AUC = 0.590) and on ward admission (AUC = 0.746), and MRC on ward admission (AUC = 0.721) were discriminative for ΔKATZWARD. For ΔKATZTOTthe variables KATZ on ICU admission (AUC = 0.621) and TLS (AUC = 0.617) were discriminative. For ΔMRCICUthe variables SAPSIII (AUC = 0.661) and MRC on ICU admission (AUC = 0.653) were discriminative. MRC on ICU (AUC = 0.681) and ward admission (AUC = 0.553) were discriminative for ΔMRCWARD. TLS (AUC = 0.649) and MRC on ward admission (AUC = 0.696) discriminative for the ΔMRCTOT.
  
  
  CONCLUSIONS
  Specific functional, clinical and demographical variables at ICU admission are associated with the functional prognosis during the hospitalization period.
authors.affiliation: Natália A Ferreira, Agnaldo José Lopes, Arthur S Ferreira, Fernando S Guimaraes, Rehabilitation Sciences Post-Graduation Program, Augusto Motta University Centre, Rio de Janeiro 21041-020, Brazil.
authors.forename: Natália A
authors.initials: NA
authors.lastname: Ferreira
authors.affiliation: Natália A Ferreira, Agnaldo José Lopes, Arthur S Ferreira, Fernando S Guimaraes, Rehabilitation Sciences Post-Graduation Program, Augusto Motta University Centre, Rio de Janeiro 21041-020, Brazil.
authors.forename: Agnaldo José
authors.initials: AJ
authors.lastname: Lopes
authors.affiliation: Natália A Ferreira, Agnaldo José Lopes, Arthur S Ferreira, Fernando S Guimaraes, Rehabilitation Sciences Post-Graduation Program, Augusto Motta University Centre, Rio de Janeiro 21041-020, Brazil.
authors.forename: Arthur S
authors.initials: AS
authors.lastname: Ferreira
authors.affiliation: Natália A Ferreira, Agnaldo José Lopes, Arthur S Ferreira, Fernando S Guimaraes, Rehabilitation Sciences Post-Graduation Program, Augusto Motta University Centre, Rio de Janeiro 21041-020, Brazil.
authors.forename: George
authors.initials: G
authors.lastname: Ntoumenopoulos
authors.affiliation: Natália A Ferreira, Agnaldo José Lopes, Arthur S Ferreira, Fernando S Guimaraes, Rehabilitation Sciences Post-Graduation Program, Augusto Motta University Centre, Rio de Janeiro 21041-020, Brazil.
authors.forename: Jerffesson
authors.initials: J
authors.lastname: Dias
authors.affiliation: Natália A Ferreira, Agnaldo José Lopes, Arthur S Ferreira, Fernando S Guimaraes, Rehabilitation Sciences Post-Graduation Program, Augusto Motta University Centre, Rio de Janeiro 21041-020, Brazil.
authors.forename: Fernando S
authors.initials: FS
authors.lastname: Guimaraes
keywords: Activities of daily living; Early mobilization; Intensive care units; Muscle strength; Post-intensive care unit syndrome; Rehabilitation