title: Prognostic value of post-Yttrium 90 radioembolization therapy 18F-fluorodeoxyglucose positron emission tomography in patients with liver tumors.
abstract: OBJECTIVE
  This study assessed the benefit of post-therapy18F-FDG PET/CT versus CT alone in identifying malignant liver tumor progression following radioembolization with Y-90 microspheres.
  
  
  METHODS
  24 patients with 44 liver tumors underwent CT imaging pre-radioembolization and PET/CT post-radioembolization. Predictive value of Response Evaluation Criteria in Solid Tumors (RECIST 1.1), The World Health Organization (WHO), mRECIST and European Association for the Study of the Liver (EASL) with PET/CT versus CT alone was assessed.
  
  
  RESULTS
  Prediction of liver malignancy progression was improved (p<0.05) for tumors labeled as non-responding based on combined PET/CT with RECIST 1.1, WHO, mRECIST, and EASL criteria compared to assessment without PET.
  
  
  CONCLUSIONS
  The addition of post-therapy PET to routine CT in patients with hepatic tumors undergoing radioembolization may improve identification of non-responding tumors.
authors.affiliation: University of California, San Diego, Radiology, San Diego, CA, USA.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Obrzut
authors.affiliation: University of California, San Diego, Radiology, San Diego, CA, USA.
authors.forename: Kevin
authors.initials: K
authors.lastname: McCammack
authors.affiliation: University of California, San Diego, School of Medicine, San Diego, CA, USA.
authors.forename: Karam W
authors.initials: KW
authors.lastname: Badran
authors.affiliation: San Jose State University, San Jose, CA, USA.
authors.forename: Anthony
authors.initials: A
authors.lastname: Balistreri
authors.affiliation: University of California, San Diego, School of Medicine, San Diego, CA, USA.
authors.forename: Evan
authors.initials: E
authors.lastname: Ou
authors.affiliation: University of California, San Diego, School of Medicine, San Diego, CA, USA. Electronic address: bjnguyen@ucsd.edu.
authors.forename: Brian J
authors.initials: BJ
authors.lastname: Nguyen
authors.affiliation: University of California, San Diego, Radiology, San Diego, CA, USA.
authors.forename: Carl K
authors.initials: CK
authors.lastname: Hoh
authors.affiliation: University of California, San Diego, Radiology, San Diego, CA, USA.
authors.forename: Steven C
authors.initials: SC
authors.lastname: Rose
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001918:Brachytherapy / Q000379:methods*; D004621:Embolization, Therapeutic / Q000379:methods*; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008113:Liver Neoplasms / Q000000981:diagnostic imaging* / Q000628:therapy; D008297:Male; D008863:Microspheres; D008875:Middle Aged; D000072078:Positron Emission Tomography Computed Tomography / Q000379:methods*; D049268:Positron-Emission Tomography / Q000379:methods; D011379:Prognosis; D019275:Radiopharmaceuticals / Q000627:therapeutic use*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D015021:Yttrium Radioisotopes / Q000627:therapeutic use*
chemical_list: D019275:Radiopharmaceuticals; D015021:Yttrium Radioisotopes; D019788:Fluorodeoxyglucose F18
keywords: (18)F FDG Pet; Liver; Radioembolization; Yttrium 90