title: Recent Developments in Cellular Immunotherapy for HSCT-Associated Complications.
abstract: Allogeneic hematopoietic stem cell transplantation is associated with serious complications, and improvement of the overall clinical outcome of patients with hematological malignancies is necessary. During the last decades, posttransplant donor-derived adoptive cellular immunotherapeutic strategies have been progressively developed for the treatment of graft-versus-host disease (GvHD), infectious complications, and tumor relapses. To date, the common challenge of all these cell-based approaches is their implementation for clinical application. Establishing an appropriate manufacturing process, to guarantee safe and effective therapeutics with simultaneous consideration of economic requirements is one of the most critical hurdles. In this review, we will discuss the recent scientific findings, clinical experiences, and technological advances for cell processing toward the application of mesenchymal stromal cells as a therapy for treatment of severe GvHD, virus-specific T cells for targeting life-threating infections, and of chimeric antigen receptors-engineered T cells to treat relapsed leukemia.
authors.affiliation: Haematological Sciences, Institute of Cellular Medicine, Newcastle University , Newcastle upon Tyne , UK.
authors.forename: Monica
authors.initials: M
authors.lastname: Reis
authors.affiliation: Transplantation Biology, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School , Hannover , Germany.
authors.forename: Justyna
authors.initials: J
authors.lastname: Ogonek
authors.affiliation: Alcyomics Ltd. , Newcastle upon Tyne , UK.
authors.forename: Marsela
authors.initials: M
authors.lastname: Qesari
authors.affiliation: Haematological Sciences, Institute of Cellular Medicine, Newcastle University , Newcastle upon Tyne , UK.
authors.forename: Nuno M
authors.initials: NM
authors.lastname: Borges
authors.affiliation: Haematological Sciences, Institute of Cellular Medicine, Newcastle University , Newcastle upon Tyne , UK.
authors.forename: Lindsay
authors.initials: L
authors.lastname: Nicholson
authors.affiliation: Miltenyi Biotec GmbH , Bergisch Gladbach , Germany.
authors.forename: Liane
authors.initials: L
authors.lastname: Preußner
authors.affiliation: Haematological Sciences, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK; Alcyomics Ltd., Newcastle upon Tyne, UK.
authors.forename: Anne Mary
authors.initials: AM
authors.lastname: Dickinson
authors.affiliation: Haematological Sciences, Institute of Cellular Medicine, Newcastle University , Newcastle upon Tyne , UK.
authors.forename: Xiao-Nong
authors.initials: XN
authors.lastname: Wang
authors.affiliation: Transplantation Biology, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School , Hannover , Germany.
authors.forename: Eva M
authors.initials: EM
authors.lastname: Weissinger
authors.affiliation: Miltenyi Biotec GmbH , Bergisch Gladbach , Germany.
authors.forename: Anne
authors.initials: A
authors.lastname: Richter
keywords: T cells; adoptive transfer; cell manufacture; chimeric antigen receptor; extracellular vesicles; immunomodulation; infection; mesenchymal stromal cells