title: Tacrolimus in combination with methotrexate and corticosteroid for the treatment of child-onset anti-signal recognition particle antibody-positive necrotizing myopathy.
authors.affiliation: a Center for Pediatric Allergy and Rheumatology , KKR Medical Center , Sapporo , Japan.|b Department of Pediatrics , Hokkaido University Graduate School of Medicine , Sapporo , Japan.
authors.forename: I
authors.initials: I
authors.lastname: Kobayashi
authors.affiliation: b Department of Pediatrics , Hokkaido University Graduate School of Medicine , Sapporo , Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Tozawa
authors.affiliation: b Department of Pediatrics , Hokkaido University Graduate School of Medicine , Sapporo , Japan.
authors.forename: M
authors.initials: M
authors.lastname: Ueki
authors.affiliation: b Department of Pediatrics , Hokkaido University Graduate School of Medicine , Sapporo , Japan.
authors.forename: S
authors.initials: S
authors.lastname: Takezaki
authors.affiliation: c Department of Pediatric Neurology , Shizuoka Children's Hospital , Shizuoka , Japan.
authors.forename: S
authors.initials: S
authors.lastname: Watanabe
authors.affiliation: d Department of Pathology , Shizuoka Children's Hospital , Shizuoka , Japan.
authors.forename: H
authors.initials: H
authors.lastname: Iwafuchi
authors.affiliation: b Department of Pediatrics , Hokkaido University Graduate School of Medicine , Sapporo , Japan.
authors.forename: M
authors.initials: M
authors.lastname: Yamada
authors.affiliation: e Department of Allergy and Rheumatology , Nippon Medical School Graduate School of Medicine , Tokyo , Japan.
authors.forename: M
authors.initials: M
authors.lastname: Kuwana
authors.affiliation: b Department of Pediatrics , Hokkaido University Graduate School of Medicine , Sapporo , Japan.
authors.forename: T
authors.initials: T
authors.lastname: Ariga
mesh_terms: D017668:Age of Onset; D001323:Autoantibodies / Q000097:blood; D001706:Biopsy / Q000379:methods; D002648:Child; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination / Q000379:methods; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage*; D018482:Muscle, Skeletal / Q000473:pathology*; D009135:Muscular Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology / Q000503:physiopathology; D009336:Necrosis; D018271:Signal Recognition Particle / Q000276:immunology*; D016559:Tacrolimus / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D001323:Autoantibodies; D005938:Glucocorticoids; D018271:Signal Recognition Particle; D016559:Tacrolimus; D008727:Methotrexate