title: Thyroid Stimulating Hormone Is Increased in Hypertensive Patients with Obstructive Sleep Apnea.
abstract: Purpose. To evaluate alteration in serum TSH in hypertensives with OSA and its relation with cardiometabolic risk factors.Methods. 517 hypertensives were cross-sectionally studied. OSA was determined by polysomnography and thyroid function by standard methods.Results. OSA was diagnosed in 373 hypertensives (72.15%). Prevalence of subclinical hypothyroidism was significantly higher in OSA hypertensives than in non-OSA ones (15.0% versus 6.9%,P= 0.014). Serum LnTSH in hypertensives with severe OSA was significantly higher (0.99 ± 0.81 versus 0.74 ± 0.77μIU/mL,P< 0.05) than in those without OSA. AHI, LSaO2, ODI3, and ODI4were independently associated with serum TSH for those aged 30-65 years. Dividing subjects into four groups as TSH < 1.0μIU/mL, 1.0 ≤ THS ≤ 1.9μIU/mL, 1.91 ≤ TSH < 4.5μIU/mL, and TSH ≥ 4.5μIU/mL, only 26.3% of OSA subjects exhibited TSH between 1.0 and 1.9μIU/mL, significantly less than non-OSA subjects (26.3% versus 38.2%,P= 0.01). DBP and serum LDL-c elevated with TSH increasing and were only significantly higher in TSH ≥ 4.5μIU/mL group than in 1.0 ≤ TSH ≤ 1.9μIU/mL group (96.32 ± 14.19 versus 92.31 ± 12.86 mmHg;P= 0.040; 0.99 ± 0.60 versus 0.87 ± 0.34 mmol/L,P= 0.023).Conclusion. OSA might be a risk factor for increased TSH even within reference range in hypertensive population.
authors.affiliation: The Center for Hypertension of the People's Hospital of Xinjiang Uygur Autonomous Region, The Center for Diagnosis, Treatment and Research of Hypertension in Xinjiang, No. 91, TianChi Road, Urumqi, Xinjiang 830001, China.
authors.forename: Nanfang
authors.identifier: 0000-0003-0614-7866
authors.initials: N
authors.lastname: Li
authors.affiliation: The Center for Hypertension of the People's Hospital of Xinjiang Uygur Autonomous Region, The Center for Diagnosis, Treatment and Research of Hypertension in Xinjiang, No. 91, TianChi Road, Urumqi, Xinjiang 830001, China.
authors.forename: Mulalibieke
authors.initials: M
authors.lastname: Heizhati
authors.affiliation: The Center for Hypertension of the People's Hospital of Xinjiang Uygur Autonomous Region, The Center for Diagnosis, Treatment and Research of Hypertension in Xinjiang, No. 91, TianChi Road, Urumqi, Xinjiang 830001, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Sun
authors.affiliation: The Center for Hypertension of the People's Hospital of Xinjiang Uygur Autonomous Region, The Center for Diagnosis, Treatment and Research of Hypertension in Xinjiang, No. 91, TianChi Road, Urumqi, Xinjiang 830001, China.
authors.forename: Suofeiya
authors.initials: S
authors.lastname: Abulikemu
authors.affiliation: The Center for Hypertension of the People's Hospital of Xinjiang Uygur Autonomous Region, The Center for Diagnosis, Treatment and Research of Hypertension in Xinjiang, No. 91, TianChi Road, Urumqi, Xinjiang 830001, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Shao
authors.affiliation: The Center for Hypertension of the People's Hospital of Xinjiang Uygur Autonomous Region, The Center for Diagnosis, Treatment and Research of Hypertension in Xinjiang, No. 91, TianChi Road, Urumqi, Xinjiang 830001, China.
authors.forename: Xiaoguang
authors.initials: X
authors.lastname: Yao
authors.affiliation: The Center for Hypertension of the People's Hospital of Xinjiang Uygur Autonomous Region, The Center for Diagnosis, Treatment and Research of Hypertension in Xinjiang, No. 91, TianChi Road, Urumqi, Xinjiang 830001, China.
authors.forename: Yingchun
authors.initials: Y
authors.lastname: Wang
authors.affiliation: The Center for Hypertension of the People's Hospital of Xinjiang Uygur Autonomous Region, The Center for Diagnosis, Treatment and Research of Hypertension in Xinjiang, No. 91, TianChi Road, Urumqi, Xinjiang 830001, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Hong
authors.affiliation: The Center for Hypertension of the People's Hospital of Xinjiang Uygur Autonomous Region, The Center for Diagnosis, Treatment and Research of Hypertension in Xinjiang, No. 91, TianChi Road, Urumqi, Xinjiang 830001, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Zhou
authors.affiliation: The Center for Hypertension of the People's Hospital of Xinjiang Uygur Autonomous Region, The Center for Diagnosis, Treatment and Research of Hypertension in Xinjiang, No. 91, TianChi Road, Urumqi, Xinjiang 830001, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.affiliation: The Center for Hypertension of the People's Hospital of Xinjiang Uygur Autonomous Region, The Center for Diagnosis, Treatment and Research of Hypertension in Xinjiang, No. 91, TianChi Road, Urumqi, Xinjiang 830001, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: The Center for Hypertension of the People's Hospital of Xinjiang Uygur Autonomous Region, The Center for Diagnosis, Treatment and Research of Hypertension in Xinjiang, No. 91, TianChi Road, Urumqi, Xinjiang 830001, China.
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authors.initials: W
authors.lastname: Zhang