title: The intricacies of the renin-angiotensin-system in metabolic regulation.
abstract: Over recent years, the renin-angiotensin-system (RAS), which is best-known as an endocrine system with established roles in hydromineral balance and blood pressure control, has emerged as a fundamental regulator of many additional physiological and pathophysiological processes. In this manuscript, we celebrate and honor Randall Sakai's commitment to his trainees, as well as his contribution to science. Scientifically, Randall made many notable contributions to the recognition of the RAS's roles in brain and behavior. His interests, in this regard, ranged from its traditionally-accepted roles in hydromineral balance, to its less-appreciated functions in stress responses and energy metabolism. Here we review the current understanding of the role of the RAS in the regulation of metabolism. In particular, the opposing actions of the RAS within adipose tissue vs. its actions within the brain are discussed.
authors.affiliation: Department of Pharmacodynamics, College of Pharmacy, University of Florida, United States.
authors.forename: Erin B
authors.initials: EB
authors.lastname: Bruce
authors.affiliation: Department of Physiology and Functional Genomics, College of Medicine, University of Florida, United States. Electronic address: adekloet@ufl.edu.
authors.forename: Annette D
authors.initials: AD
authors.lastname: de Kloet
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000378:metabolism; D004734:Energy Metabolism / Q000502:physiology*; D006801:Humans; D012084:Renin-Angiotensin System / Q000502:physiology*
keywords: Angiotensin-converting enzyme 2; Angiotensinogen; Food intake; Obesity; White adipose tissue