title: MicroRNA biogenesis: Epigenetic modifications as another layer of complexity in the microRNA expression regulation.
abstract: Since their discovery, microRNAs have led to a huge shift in our understanding of the regulation of key biological processes. The discovery of epigenetic modifications that affect microRNA expression has added another layer of complexity to the already tightly controlled regulatory machinery. Modifications like uridylation, adenylation and RNA editing have been shown to have variable effects on miRNA biogenesis and action. Methylation of the N6 adenosine has been studied extensively in mRNA. Presence of the N6-methyl-adenosine (m6A) mark and its critical importance in miRNA biogenesis in animals adds to our understanding of the regulatory mechanisms, while its effect on miRNA biogenesis in plants is yet to be understood.
authors.affiliation: Department of Gene Expression, Institute of Molecular Biology and Biotechnology, Faculty of Biology, Adam Mickiewicz University, Poznań, Poland.
authors.forename: Susheel Sagar
authors.initials: SS
authors.lastname: Bhat
authors.affiliation: Department of Gene Expression, Institute of Molecular Biology and Biotechnology, Faculty of Biology, Adam Mickiewicz University, Poznań, Poland.
authors.forename: Artur
authors.initials: A
authors.lastname: Jarmolowski
authors.affiliation: Department of Gene Expression, Institute of Molecular Biology and Biotechnology, Faculty of Biology, Adam Mickiewicz University, Poznań, Poland.
authors.forename: Zofia
authors.initials: Z
authors.lastname: Szweykowska-Kulińska
mesh_terms: D000818:Animals; D044127:Epigenesis, Genetic; D006801:Humans; D055029:Inverted Repeat Sequences; D035683:MicroRNAs / Q000096:biosynthesis* / Q000235:genetics; D018749:RNA, Plant / Q000235:genetics / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: D035683:MicroRNAs; D018749:RNA, Plant