title: One pot synthesis of α-ketoamides from ethylarenes and amines: a metal free difunctionalization strategy.
abstract: One-pot and metal free synthesis of α-ketoamides has been described through in situ generation of aryl ketones from easily available ethylarenes followed by amidation with various amines. This multiple oxidation protocol involves catalytic I2-pyridine-TBHP (t-butyl hydroperoxide) mediated oxidative benzylic carbonylation and sequential NaI-TBHP mediated oxidative amidation without using any solvent.
authors.affiliation: Department of Chemistry, National Taiwan University, Taipei 106, Taiwan. stliu@ntu.edu.tw.
authors.forename: Mani
authors.initials: M
authors.lastname: Ramanathan
authors.forename: Chun-Kai
authors.initials: CK
authors.lastname: Kuo
authors.forename: Shiuh-Tzung
authors.initials: ST
authors.lastname: Liu