title: Can Serum ICAM 1 distinguish pancreatic cancer from chronic
  pancreatitis?
abstract: Background and aim: Pancreatic cancer is the fourth leading cause of cancer-related death worldwide, with an
  overall 5-year survival of <5% mainly due to presence of advanced disease at time of diagnosis. Therefore development
  of valid biomarkers to diagnose pancreatic cancer in early stages is an urgent need. This study concerned the sensitivity
  and specificity of serum ICAM 1 versus CA 19-9 in differentiation between pancreatic cancer and healthy subjects
  and acohort of patients with chronic pancreatitis with a focus on assessing validity in diagnosis of early stages of
  pancreatic cancer. Methods: A cohort of 50 patients with histologically diagnosed pancreatic tumors, 27 patients with
  chronic pancreatitis, and 35 healthy controls were enrolled. Serum samples for measurement of CA19-9 and I-CAM 1
  were obtained from all groups and analyzed for significance regarding diagnosis and disease stage. Results: At a cut
  off value of (878.5 u/ml) I-CAM 1 had 82% and 82.26% sensitivity and specificity for differentiation between cancer
  and non-cancer cases, with higher sensitivity and specificity than CA19-9 at different cut offs (CA19-9 sensitivity and
  specificity ranged from 64-80% and 56.4 – 61.2% respectively). The AUC was 0.851 for I-CAM and 0.754 for CA19-9.
  Neither of the markers demonstrated significance for distinguishing between early and late cancer stages. Conclusion:
  ICAM 1 is a useful marker in differentiation between malignant and benign pancreatic conditions, and superior to
  CA19-9 in this regard. However, neither of the markers can be recommended for use in differentiation between early
  and late stage pancreatic cancers.
authors.affiliation: Department of Medical Biochemistry, National Hepatology and Tropical Medicine Research Institute, Cairo, Egypt. Email: r_m_tawfik@yahoo.com
authors.forename: amal
authors.initials: A
authors.lastname: mohamed
authors.forename: Yasmine
authors.initials: Y
authors.lastname: Saad
authors.forename: Doaa
authors.initials: D
authors.lastname: Saleh
authors.forename: Rehab
authors.initials: R
authors.lastname: Elawady
authors.forename: Rasha
authors.initials: R
authors.lastname: Eletreby
authors.forename: Ahmad S
authors.initials: AS
authors.lastname: Kharalla
authors.forename: Eman
authors.initials: E
authors.lastname: Badr
keywords: Pancreatic cancer; I-CAM; CA19-9; chronic pancreatitis