title: Association of SP-C gene codon 186 polymorphism (rs1124) and risk of RDS.
abstract: BACKGROUND
  Respiratory distress syndrome (RDS) is a severe pulmonary disease that mainly affects preterm neonates. Surfactant-protein genes' polymorphisms have been mostly evaluated as the candidate contributors in genetics of RDS. However, the results are diverse in different populations. We aimed at investigating the association of rs1124 with RDS development.
  
  
  METHODS
  Three hundred and thirty five preterm neonates were enrolled in a multicenter case-control study. Respiratory distress (RD) was scored according to Downes' scoring system. Genotyping was performed by PCR-RFLP method.
  
  
  RESULTS
  One hundred and sixty six neonates showed RDS and 169 did not. Gestational age (GA) was significantly lower in RDS group compared to the controls. In female preterm newborns, AA genotype was found more frequently in RDS group. In RDS group, AA genotype was also associated with milder RD irrespective of gender. In neonates who were born 28-34 weeks, RD appeared to be more severe in the RDS group and males.
  
  
  CONCLUSIONS
  This is the first report of association of SFTPC rs1124 polymorphism with RDS development in Iranian newborns. The current study suggests that GA <28-weeks is the most important factor in predisposition to RDS. AA genotype is also, a predisposing factor for the development of RDS in female preterm infants.
authors.affiliation: a Maternal, Fetal and Neonatal Research Center, Tehran University of Medical Sciences , Tehran , Iran.|b Ronash Medical Genetic Center , Tehran , Iran.
authors.forename: Neda
authors.initials: N
authors.lastname: Fatahi
authors.affiliation: c Breast feeding Research Center, Tehran University of Medical Sciences , Tehran , Iran.
authors.forename: Hosein
authors.initials: H
authors.lastname: Dalili
authors.affiliation: d Akbarabadi Hospital, Iran University of Medical Sciences , Tehran , Iran.
authors.forename: Majid
authors.initials: M
authors.lastname: Kalani
authors.affiliation: a Maternal, Fetal and Neonatal Research Center, Tehran University of Medical Sciences , Tehran , Iran.|c Breast feeding Research Center, Tehran University of Medical Sciences , Tehran , Iran.
authors.forename: Nikoo
authors.initials: N
authors.lastname: Niknafs
authors.affiliation: a Maternal, Fetal and Neonatal Research Center, Tehran University of Medical Sciences , Tehran , Iran.|c Breast feeding Research Center, Tehran University of Medical Sciences , Tehran , Iran.
authors.forename: Mamak
authors.initials: M
authors.lastname: Shariat
authors.affiliation: e Department of Medical Genetics , Faculty of Medicine, Tehran University of Medical Sciences , Tehran , Iran.
authors.forename: Javad
authors.initials: J
authors.lastname: Tavakkoly-Bazzaz
authors.affiliation: a Maternal, Fetal and Neonatal Research Center, Tehran University of Medical Sciences , Tehran , Iran.|f Department of Pediatrics , Faculty of Medicine, Tehran University of Medical Sciences , Tehran , Iran.
authors.forename: Elaheh
authors.initials: E
authors.lastname: Amini
authors.affiliation: a Maternal, Fetal and Neonatal Research Center, Tehran University of Medical Sciences , Tehran , Iran.|f Department of Pediatrics , Faculty of Medicine, Tehran University of Medical Sciences , Tehran , Iran.
authors.forename: Tahereh
authors.initials: T
authors.lastname: Esmaeilnia Shirvani
authors.affiliation: a Maternal, Fetal and Neonatal Research Center, Tehran University of Medical Sciences , Tehran , Iran.|g School of Medicine, Ahwaz Jundishapur University of Medical Sciences , Ahwaz , Iran , and.
authors.forename: Amir Kamal
authors.initials: AK
authors.lastname: Hardani
authors.affiliation: c Breast feeding Research Center, Tehran University of Medical Sciences , Tehran , Iran.|h Department of Pediatrics , Faculty of Medicine, Shahid Beheshti University of medical Sciences , Tehran , Iran.
authors.forename: Roya
authors.initials: R
authors.lastname: Taheritafti
authors.affiliation: a Maternal, Fetal and Neonatal Research Center, Tehran University of Medical Sciences , Tehran , Iran.
authors.forename: Nasrin
authors.initials: N
authors.lastname: Ghasemi-Fakhr
authors.affiliation: e Department of Medical Genetics , Faculty of Medicine, Tehran University of Medical Sciences , Tehran , Iran.
authors.forename: Mohsen
authors.initials: M
authors.lastname: Ghadami
authors.affiliation: a Maternal, Fetal and Neonatal Research Center, Tehran University of Medical Sciences , Tehran , Iran.|c Breast feeding Research Center, Tehran University of Medical Sciences , Tehran , Iran.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Nayeri
authors.affiliation: a Maternal, Fetal and Neonatal Research Center, Tehran University of Medical Sciences , Tehran , Iran.|b Ronash Medical Genetic Center , Tehran , Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Rashidi-Nezhad
mesh_terms: D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D020641:Polymorphism, Single Nucleotide; D037721:Pulmonary Surfactant-Associated Protein C / Q000235:genetics*; D012127:Respiratory Distress Syndrome, Newborn / Q000235:genetics*
chemical_list: D037721:Pulmonary Surfactant-Associated Protein C; C489679:SFTPC protein, human
keywords: Iran; RDS; SP-C; SP-C codon 186 polymorphism; SPC N186S; association; single-nucleotide polymorphism; surfactant protein C