title: Patterns of Recurrence after Resection of Mass-Forming Type
  Intrahepatic Cholangiocarcinomas
abstract: Background: Intrahepatic cholangiocarcinoma (IHCCA) is an aggressive tumor for which surgical resection is
  a mainstay of treatment. However, recurrence after resection is common associated with a poor prognosis. Studies
  regarding recurrence of mass-forming IHCCA are rare; therefore, we investigated the pattern with our dataset. Methods:
  We retrospectively reviewed the medical and pathological records of 50 mass-forming IHCCA patients who underwent
  hepatic resection between January 2004 and December 2009 in order to determine the patterns of recurrence and
  prognosis. All demographic and operative parameters were analyzed for their effects on recurrence-free survival.
  Results: The median recurrence-free survival time was 188 days (95%CI: 149-299). The respective 1-, 2-, and 3-year
  recurrence-free survival rates were 16.2% (95%CI: 6.6-29.4), 5.4% (95%CI: 1.0-15.8) and 2.7% (95%CI: 0.2-12.0).
  There was an equal distribution of recurrence at solitary and multiple sites. Univariate analysis revealed no factors
  related to recurrence-free survival.Conclusion: The overall survival and recurrence-free survival after surgery for
  mass-forming IHCCA were found to be very poor. Almost all recurrences were detected within 2 years after surgery.
  Adjuvant chemotherapy after surgery may add benefit in the affected patients.
authors.affiliation: Department of Surgery, Faculty of Medicine, Khon Kaen University,  Khon Kaen, 40002, Thailand. Email: vor_110@yahoo.com
authors.forename: Vor
authors.initials: V
authors.lastname: Luvira
authors.forename: Chalerm
authors.initials: Ch
authors.lastname: Eurboonyanun
authors.forename: Vajarabhongsa
authors.initials: V
authors.lastname: Bhudhisawasdi
authors.forename: Ake
authors.initials: A
authors.lastname: Pugkhem
authors.forename: Chawalit
authors.initials: Ch
authors.lastname: Pairojkul
authors.forename: Varisara
authors.initials: V
authors.lastname: Luvira
authors.forename: Egapong
authors.initials: E
authors.lastname: Sathitkarnmanee
authors.forename: Kulyada
authors.initials: K
authors.lastname: Somsap
authors.forename: Supot
authors.initials: S
authors.lastname: Kamsa-ard
keywords: Mass forming intrahepatic cholangiocarcinoma; recurrence; survival; curative resection