title: Polymorphism of the complement 5 gene is associated with large artery atherosclerosis stroke in Chinese patients.
abstract: METHODS
  C5 rs17611 genetic variants were investigated in 494 IS patients and 330 control individuals .Ischemic stroke was classiﬁed into subtypes and patients were assessed 90 days post-stroke with the modified Rankin Scale to determine stroke outcome.
  
  
  RESULTS
  The presence of C5 polymorphism was associated with the incidence of large artery atherosclerosis (LAA)-subtype IS (n =2 00; p = 0.031), which even persisted after adjustment for covariates (OR = 1.518; 95%CI = 1.093-2.018; p = 0.013). However, no association was found between genotypes and the severity and outcome of stroke (p = 0.978; p = 0.296).
  
  
  CONCLUSIONS
  The C5 polymorphism might contribute to the risk of LAA-subtype IS independently of other known risk predictors.
authors.affiliation: Minhang District Central Hospital, Department of Neurology, Shanghai, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Wu
authors.affiliation: Minhang District Central Hospital, Department of Neurology, Shanghai, China.
authors.forename: Yingfeng
authors.initials: Y
authors.lastname: Weng
authors.affiliation: Minhang District Central Hospital, Department of Neurology, Shanghai, China.
authors.forename: Lan
authors.initials: L
authors.lastname: Zheng
authors.affiliation: Minhang District Central Hospital, Department of Neurology, Shanghai, China.
authors.forename: Huanyin
authors.initials: H
authors.lastname: Li
authors.affiliation: Minhang District Central Hospital, Department of Neurology, Shanghai, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Gong
authors.affiliation: Shanghai Jiao Tong University School of Medicine, Ruijin Hospital.
authors.forename: Yi
authors.initials: Y
authors.lastname: Fu
authors.affiliation: Minhang District Central Hospital, Department of Neurology, Shanghai, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhao
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000235:genetics; D050197:Atherosclerosis / Q000235:genetics*; D002681:China; D003182:Complement C5 / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012720:Severity of Illness Index; D020521:Stroke / Q000235:genetics*
chemical_list: D003182:Complement C5