title: Interaction of gut microbiota with bile acid metabolism and its influence on disease states.
abstract: Primary bile acids serve important roles in cholesterol metabolism, lipid digestion, host-microbe interactions, and regulatory pathways in the human host. While most bile acids are reabsorbed and recycled via enterohepatic cycling, ∼5% serve as substrates for bacterial biotransformation in the colon. Enzymes involved in various transformations have been characterized from cultured gut bacteria and reveal taxa-specific distribution. More recently, bioinformatic approaches have revealed greater diversity in isoforms of these enzymes, and the microbial species in which they are found. Thus, the functional roles played by the bile acid-transforming gut microbiota and the distribution of resulting secondary bile acids, in the bile acid pool, may be profoundly affected by microbial community structure and function. Bile acids and the composition of the bile acid pool have historically been hypothesized to be associated with several disease states, including recurrent Clostridium difficile infection, inflammatory bowel diseases, metabolic syndrome, and several cancers. Recently, however, emphasis has been placed on how microbial communities in the dysbiotic gut may alter the bile acid pool to potentially cause or mitigate disease onset. This review highlights the current understanding of the interactions between the gut microbial community, bile acid biotransformation, and disease states, and addresses future directions to better understand these complex associations.
authors.affiliation: BioTechnology Institute, Center for Immunology University of Minnesota, Minneapolis, MN.
authors.forename: Christopher
authors.initials: C
authors.lastname: Staley
authors.affiliation: BioTechnology Institute, Center for Immunology University of Minnesota, Minneapolis, MN.
authors.forename: Alexa R
authors.initials: AR
authors.lastname: Weingarden
authors.affiliation: BioTechnology Institute, Center for Immunology University of Minnesota, Minneapolis, MN.|Division of Gastroenterology, Department of Medicine, Center for Immunology University of Minnesota, Minneapolis, MN.
authors.forename: Alexander
authors.initials: A
authors.lastname: Khoruts
authors.affiliation: BioTechnology Institute, Center for Immunology University of Minnesota, Minneapolis, MN.|Department of Soil, Water and Climate, University of Minnesota, St. Paul, MN.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Sadowsky
mesh_terms: D001647:Bile Acids and Salts / Q000378:metabolism*; D001711:Biotransformation; D064806:Dysbiosis; D005767:Gastrointestinal Diseases; D000069196:Gastrointestinal Microbiome; D006801:Humans
chemical_list: D001647:Bile Acids and Salts
keywords: Bile acids; C. difficile; Dysbiosis; Host-interactions; Microbial metabolism