title: Body girdle reduced fat deposition and altered other body parameters in rats.
abstract: Many women favor in wearing foundation garments to shape their body and show satisfactory figures. However, few investigations have been conducted on the physiological impact of wearing tight garments on the body. In this study, we used girdled rats that were fed with a high fat diet to investigate their physiological condition including alterations in food intake, body weight, fat deposition, and hormone concentrations. Over the experiment period, girdled rats maintained normal plasma and liver cholesterol and triglyceride. Leptin level in girdled rats was significantly lower than that in normal control. The fat tissue of girdled rats was more active in secretion of leptin, which might be mediated by mTOR signaling. Girdled rats showed no difference in hematology analysis during the experiment period. This study showed that a body girdle can significantly reduce fat deposition and alter other body parameters in rats.
authors.affiliation: Department of Intervention and Vascular Surgery, Peking University Third Hospital, Beijing, China.
authors.forename: T-R
authors.initials: TR
authors.lastname: Li
authors.affiliation: Department of Dermatology, Peking University Shenzhen Hospital, Shenzhen, China.
authors.forename: B-C
authors.initials: BC
authors.lastname: Chen
authors.affiliation: Department of Dermatology, Peking University Shenzhen Hospital, Shenzhen, China.
authors.forename: Y-F
authors.initials: YF
authors.lastname: Zou
authors.affiliation: Department of Dermatology, Peking University Shenzhen Hospital, Shenzhen, China.
authors.forename: J
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Biomedical Research Institute, Shenzhen Peking University-the Hong Kong University of Science and Technology Medical Center, Shenzhen, China.
authors.forename: W
authors.initials: W
authors.lastname: Zhang
authors.affiliation: National Key Laboratory of Animal Nutrition, China Agricultural University, Beijing, China.
authors.forename: B
authors.initials: B
authors.lastname: Dong
authors.affiliation: Department of Intervention and Vascular Surgery, Peking University Third Hospital, Beijing, China. xuanli@vip.sina.com.
authors.forename: X
authors.initials: X
authors.lastname: Li
authors.affiliation: Biomedical Research Institute, Shenzhen Peking University-the Hong Kong University of Science and Technology Medical Center, Shenzhen, China. littlecanva@163.com.
authors.forename: X-F
authors.initials: XF
authors.lastname: Chen
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D050154:Adiposity; D000818:Animals; D003020:Clothing; D058128:Compression Bandages; D004435:Eating; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood; D008099:Liver / Q000378:metabolism / Q000473:pathology; D008297:Male; D009929:Organ Size; D017207:Rats, Sprague-Dawley; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism; D015430:Weight Gain
chemical_list: D008055:Lipids; D058570:TOR Serine-Threonine Kinases