title: An Overview of Neolignans of the Genus Piper L.: Isolation Methods and Biological Activities.
abstract: BACKGROUND
  The genus Piper L. has the shikimic acid pathway predominantly expressed, biosynthesizing many cinnamic acid derivatives (CAD).
  
  
  OBJECTIVE
  Neolignans comprise an important class of CAD that exhibit a wide range of pharmacological properties such as antibacterial, antitumor, insecticidal, anti-inflammatory, antioxidant, smooth muscle relaxant, neuroprotective, antiprotozoal and against platelet aggregation factor. These substances have been extracted and isolated from Piper species using different technics.
  
  
  RESULTS
  The present review aims to summarize extraction and isolation methods and biological activities of the different types of neolignans covering the period from 1968 to January 2016.
authors.affiliation: Departamento de Quimica Organica, Instituto de Quimica, Universidade Federal Fluminense, Niteroi, Brazil.
authors.forename: Arthur Ladeira
authors.initials: AL
authors.lastname: Macedo
authors.affiliation: Departamento de Quimica Organica, Instituto de Quimica, Universidade Federal Fluminense, Niteroi, Brazil.
authors.forename: Thais Carvalho Costa
authors.initials: TCC
authors.lastname: Dos Santos
authors.affiliation: Departamento de Quimica Organica, Instituto de Quimica, Universidade Federal Fluminense, Niteroi, Brazil.
authors.forename: Alessandra Leda
authors.initials: AL
authors.lastname: Valverde
authors.affiliation: Departamento de Produtos Naturais, Instituto de Tecnologia em Farmacos, Fundacao Oswaldo Cruz, Rio de Janeiro, Brazil.
authors.forename: Davyson de Lima
authors.initials: DL
authors.lastname: Moreira
authors.affiliation: Departmento de Quimica Organica, Instituto de Quimica, Universidade Federal Fluminense, CEP: 24020-141, Niteroi, Brazil.
authors.forename: Thatyana Rocha Alves
authors.initials: TRA
authors.lastname: Vasconcelos
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D018696:Neuroprotective Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D031701:Piper / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000970:Antineoplastic Agents; D000975:Antioxidants; D000981:Antiprotozoal Agents; D017705:Lignans; D018696:Neuroprotective Agents; D010936:Plant Extracts
keywords: Biological activity; Piper; Piperaceae; extraction; isolation; natural products; neolignans