title: Haemodynamic and functional consequences of the iatrogenic atrial septal defect following Mitraclip therapy.
abstract: Percutaneous MitraClip placement for treatment of severe mitral regurgitation in high surgical risk patients is a commonly performed procedure and requires a transseptal puncture to reach the left atrium. The resulting iatrogenic atrial septal defect (iASD) is not routinely closed, yet the haemodynamic and functional consequences of a persisting defect are not fully understood. Despite positive effects such as acute left atrial pressure relief, persisting iASDs are associated with negative consequences, namely significant bidirectional shunting and subsequent worse clinical outcome. Percutaneous closure of the iASD may therefore be desirable in selected cases. In this review we discuss the available literature on this matter.
authors.affiliation: Department of Cardiology, division Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands. e.a.hart-5@umcutrecht.nl.
authors.forename: E A
authors.initials: EA
authors.lastname: Hart
authors.affiliation: Department of Cardiology, division Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands.
authors.forename: K
authors.initials: K
authors.lastname: Zwart
authors.affiliation: Department of Cardiology, division Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands.
authors.forename: A J
authors.initials: AJ
authors.lastname: Teske
authors.affiliation: Department of Cardiology, division Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands.
authors.forename: M
authors.initials: M
authors.lastname: Voskuil
authors.affiliation: Department of Cardiology, division Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands.
authors.forename: P R
authors.initials: PR
authors.lastname: Stella
authors.affiliation: Department of Cardiology, division Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands.
authors.forename: S A J
authors.initials: SA
authors.lastname: Chamuleau
authors.affiliation: Department of Cardiology, division Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands.
authors.forename: A O
authors.initials: AO
authors.lastname: Kraaijeveld
keywords: Iatrogenic atrial septal defect; MitraClip; Mitral regurgitation