title: Structure Elucidation of Antibiotics by Nmr Spectroscopy.
abstract: Nuclear magnetic resonance (NMR) spectroscopy is a powerful tool for the structure elucidation of antibiotics in solution. Over the past 30 years there have been numerous publications describing the use of NMR to characterize naturally derived or synthetic antibiotics. A large number of one-dimensional (1D) and two-dimensional (2D) NMR methods are available today and the list continues to expand. In this chapter, we will consider the key NMR experiments that provide useful information for compound structure elucidation.
authors.affiliation: Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine-University, Universitaetsstrasse 1, 40225, Duesseldorf, Germany. georgios.daletos@uni-duesseldorf.de.
authors.forename: Georgios
authors.initials: G
authors.lastname: Daletos
authors.affiliation: Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine-University, Universitaetsstrasse 1, 40225, Duesseldorf, Germany.
authors.forename: Elena
authors.initials: E
authors.lastname: Ancheeva
authors.affiliation: Pharmacognosy Department, Faculty of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
authors.forename: Raha S
authors.initials: RS
authors.lastname: Orfali
authors.affiliation: Helmholtz Centre for Infection Research, Inhoffenstrasse 7, 38124, Braunschweig, Germany.
authors.forename: Victor
authors.initials: V
authors.lastname: Wray
authors.affiliation: Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine-University, Universitaetsstrasse 1, 40225, Duesseldorf, Germany. proksch@uni-duesseldorf.de.
authors.forename: Peter
authors.initials: P
authors.lastname: Proksch
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry*; D066241:Carbon-13 Magnetic Resonance Spectroscopy; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D010456:Peptides, Cyclic / Q000737:chemistry; D066244:Proton Magnetic Resonance Spectroscopy
chemical_list: D000900:Anti-Bacterial Agents; D010456:Peptides, Cyclic; C000602713:callyaerin A
keywords: Antibiotics; Callyaerin A; NMR; Natural products; Structure elucidation