title: Hypertension, Left Ventricular Hypertrophy, and Myocardial Ischemia.
abstract: The risks associated with hypertension emerge through a series of complex interactions. Myocardial ischemia is the major contributor to this risk. The mechanisms driving ischemia reflect many of the key factors in hypertension, including endothelial and neurohumoral factors, fibrosis, and hemodynamics. Left ventricular hypertrophy and fibrosis are of fundamental importance and together with hemodynamics provide an optimal template for myocardial ischemia. Understanding the pathophysiology has aided a more rational management approach but challenges remain which, if surmounted, will have an impact on the morbidity and mortality caused by myocardial ischemia in patients with hypertension.
authors.affiliation: Nambour Hospital, School of Medicine, University of Queensland, Medical Suites, Level 2, Nambour, Queensland 4556, Australia.
authors.forename: Tony
authors.initials: T
authors.lastname: Stanton
authors.affiliation: University of Glasgow, Glasgow G12 8QQ, Scotland. Electronic address: fgdunn@sky.com.
authors.forename: Francis G
authors.initials: FG
authors.lastname: Dunn
mesh_terms: D000222:Adaptation, Physiological; D000959:Antihypertensive Agents / Q000627:therapeutic use; D003327:Coronary Disease / Q000150:complications* / Q000503:physiopathology; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology*; D017379:Hypertrophy, Left Ventricular / Q000209:etiology / Q000503:physiopathology*; D017202:Myocardial Ischemia / Q000000981:diagnostic imaging / Q000209:etiology / Q000401:mortality / Q000503:physiopathology*
chemical_list: D000959:Antihypertensive Agents
keywords: Hypertension; Ischemia; Management; Mechanisms; Perfusion