title: Lung-protective ventilatory strategies in intubated preterm neonates with RDS.
abstract: This article provides a narrative review of lung-protective ventilatory strategies (LPVS) in intubated preterm infants with RDS. A description of strategies is followed by results on short-and long-term respiratory and neurodevelopmental outcomes. Strategies will include patient-triggered or synchronized ventilation, volume targeted ventilation, the technique of intubation, surfactant administration and rapid extubation to NCPAP (INSURE), the open lung concept, strategies of high-frequency ventilation, and permissive hypercapnia. Based on this review single recommendations on optimal LPVS cannot be made. Combinations of several strategies, individually applied, most probably minimize or avoid potential serious respiratory and cerebral complications like bronchopulmonary dysplasia and cerebral palsy.
authors.affiliation: Division of Neonatology, Department of Pediatrics and Adolescence Medicine, Medical University Graz, Austria. Electronic address: friedrich.reiterer@medunigraz.at.
authors.forename: F
authors.initials: F
authors.lastname: Reiterer
authors.affiliation: Division of Neonatology, Department of Pediatrics and Adolescence Medicine, Medical University Graz, Austria.
authors.forename: B
authors.initials: B
authors.lastname: Schwaberger
authors.affiliation: Division of Neonatology, Department of Pediatrics and Adolescence Medicine, Medical University Graz, Austria.
authors.forename: T
authors.initials: T
authors.lastname: Freidl
authors.affiliation: Centre for the Studies of Asphyxia and Resuscitation, Neonatal Research Unit, Royal Alexandra Hospital, Edmonton, Canada; Department of Pediatrics, University of Alberta, Edmonton, Canada.
authors.forename: G
authors.initials: G
authors.lastname: Schmölzer
authors.affiliation: Division of Neonatology, Department of Pediatrics and Adolescence Medicine, Medical University Graz, Austria.
authors.forename: G
authors.initials: G
authors.lastname: Pichler
authors.affiliation: Division of Neonatology, Department of Pediatrics and Adolescence Medicine, Medical University Graz, Austria.
authors.forename: B
authors.initials: B
authors.lastname: Urlesberger
mesh_terms: D001997:Bronchopulmonary Dysplasia / Q000209:etiology / Q000517:prevention & control*; D002547:Cerebral Palsy / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000503:physiopathology / Q000628:therapy*; D008168:Lung / Q000254:growth & development / Q000503:physiopathology; D010346:Patient Care Management / Q000379:methods; D012121:Respiration, Artificial / Q000295:instrumentation / Q000379:methods
keywords: Lung protective strategies; RDS; mechanical ventilation; preterm infants; short- and long-term outcome