title: Does insulin resistance increase thyroid volume in patients with polycystic ovary syndrome?
abstract: OBJECTIVE
  To investigate the effect of gonadotropin, sex hormone levels and insulin resistance (IR) on thyroid functions and thyroid volume (TV) in polycystic ovary syndrome (PCOS).
  
  
  METHODS
  69 new diagnosed PCOS patients (age 24.82 ± 6.17) and 56 healthy control female (age 26.69 ± 5.25) were involved to the study. Fasting plasma glucose, lipid profile, insulin, thyroid stimulating hormone (TSH), free thyroxine (fT4), estradiol (E2), luteinizing hormone (LH), follicle stimulating hormone levels and urine iodine were measured in all participants. Thyroid and pelvic ultrasound were performed in all participants.
  
  
  RESULTS
  Insulin, HOMA-IR, LH, E2 and TV were higher in PCOS group (p < 0.05). TV was significantly higher in PCOS patients with IR compared to non-IR PCOS patients (p < 0.001), while TSH, fT4, and urine iodine levels were similar between these groups (p > 0.05). There was a negative correlation between E2 and TSH (p < 0.05) and a positive correlation between TSH and TV (p < 0.05). There was a significant positive correlation between TV and LH, insulin, HOMA-IR (p < 0.05).
  
  
  CONCLUSIONS
  This study showed that TV was increased in patients with insulin resistance but differences in TSH and LH levels may affect TV changes as well.
authors.affiliation: Kahramanmaras Sutcu Imam University, Faculty of Medicine, Department of Endocrinology and Metabolism, Kahramanmaras, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Sahin
authors.affiliation: Kahramanmaras Sutcu Imam University, Faculty of Medicine, Department of Internal Medicine, Kahramanmaras, Turkey.
authors.forename: Didem
authors.initials: D
authors.lastname: Demircioglu
authors.affiliation: Kahramanmaras Sutcu Imam University, Faculty of Medicine, Department of Endocrinology and Metabolism, Kahramanmaras, Turkey.
authors.forename: Ayten
authors.initials: A
authors.lastname: Oguz
authors.affiliation: Kahramanmaras Sutcu Imam University, Faculty of Medicine, Department of Endocrinology and Metabolism, Kahramanmaras, Turkey.
authors.forename: Dilek
authors.initials: D
authors.lastname: Tuzun
authors.affiliation: Kahramanmaras Sutcu Imam University, Faculty of Medicine, Department of Radiodiagnostic, Kahramanmaras, Turkey.
authors.forename: Mehmet Akif
authors.initials: MA
authors.lastname: Sarica
authors.affiliation: Kahramanmaras Sutcu Imam University, Faculty of Medicine, Department of Internal Medicine, Kahramanmaras, Turkey.
authors.forename: Elif
authors.initials: E
authors.lastname: Inanc
authors.affiliation: Kahramanmaras Sutcu Imam University, Faculty of Medicine, Department of Endocrinology and Metabolism, Kahramanmaras, Turkey.
authors.forename: Kamile
authors.initials: K
authors.lastname: Gul
mesh_terms: D000293:Adolescent; D000328:Adult; D015992:Body Mass Index; D016022:Case-Control Studies; D005260:Female; D006062:Gonadotropins / Q000097:blood*; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D009929:Organ Size; D011085:Polycystic Ovary Syndrome / Q000378:metabolism* / Q000503:physiopathology*; D011446:Prospective Studies; D012016:Reference Values; D018709:Statistics, Nonparametric; D013959:Thyroid Diseases / Q000097:blood / Q000503:physiopathology; D013961:Thyroid Gland / Q000378:metabolism* / Q000473:pathology* / Q000503:physiopathology*; D014463:Ultrasonography; D055815:Young Adult
chemical_list: D006062:Gonadotropins