title: Prolonged hydrocephalus induced by intraventricular hemorrhage in rats is reduced by curcumin therapy.
abstract: Prolonged hydrocephalus is a major cause of severe disability and death of intraventricular hemorrhage (IVH) patients. However, the therapeutic options to minimize the detrimental effects of post-hemorrhagic hydrocephalus are limited. Curcumin has been reported to confer neuroprotective effects in numerous neurological diseases and injuries, but its role in IVH-induced hydrocephalus has not been determined. The aim of present study was to determine whether curcumin treatment ameliorates blood brain barrier (BBB) damage and reduces the incidence of post-hemorrhagic hydrocephalus in IVH rat model. Autologous blood intraventricular injection was used to establish the IVH model. Our results revealed that repeated intraperitoneal injection of curcumin ameliorated IVH-induced learning and memory deficits as determined by Morris water maze and reduced the incidence of post-hemorrhagic hydrocephalus in a dose-dependent manner at 28 d post-IVH induction. Further, the increased BBB permeability and brain edema induced by IVH were significantly reduced by curcumin administration. In summary, these findings highlighted the important role of curcumin in improving neurological function deficits and protecting against BBB disruption via promoting the neurovascular unit restoration, and thus it reduced the severity of post-hemorrhagic hydrocephalus in the long term. It is believed that curcumin might prove to be an effective therapeutic component in prevent the post-IVH hydrocephalus in the near future.
authors.affiliation: Hubei Medical College Affiliated Xiangyang No.1 People's Hospital, People's Republic of China.
authors.forename: Zhihua
authors.initials: Z
authors.lastname: Qi
authors.affiliation: Hubei Medical College Affiliated Xiangyang No.1 People's Hospital, People's Republic of China.
authors.forename: Huiqin
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Hubei Medical College Affiliated Xiangyang No.1 People's Hospital, People's Republic of China.
authors.forename: Chuhua
authors.initials: C
authors.lastname: Fu
authors.affiliation: Hubei Medical College Affiliated Xiangyang No.1 People's Hospital, People's Republic of China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Liu
authors.affiliation: Hubei Medical College Affiliated Xiangyang No.1 People's Hospital, People's Republic of China.
authors.forename: Bo
authors.initials: B
authors.lastname: Chen
authors.affiliation: Hubei Medical College Affiliated Xiangyang No.1 People's Hospital, People's Republic of China.
authors.forename: Yanwei
authors.initials: Y
authors.lastname: Dang
authors.affiliation: Hubei Medical College Affiliated Xiangyang No.1 People's Hospital, People's Republic of China.
authors.forename: Huayun
authors.initials: H
authors.lastname: Chen
authors.affiliation: Hubei Medical College Affiliated Xiangyang No.1 People's Hospital, People's Republic of China. Electronic address: 15823540630@163.com.
authors.forename: Lijun
authors.initials: L
authors.lastname: Liu
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects; D001929:Brain Edema / Q000209:etiology; D002543:Cerebral Hemorrhage / Q000150:complications / Q000188:drug therapy*; D002552:Cerebral Ventricles / Q000378:metabolism; D003474:Curcumin / Q000008:administration & dosage / Q000494:pharmacology*; D004195:Disease Models, Animal; D006801:Humans; D006849:Hydrocephalus / Q000209:etiology*; D007276:Injections, Intraventricular / Q000379:methods; D008297:Male; D018696:Neuroprotective Agents / Q000008:administration & dosage / Q000494:pharmacology*; D017207:Rats, Sprague-Dawley
chemical_list: D018696:Neuroprotective Agents; D003474:Curcumin
keywords: Blood brain barrier; Curcumin; Hydrocephalus; Intraventricular hemorrhage