title: PHACTR1 and SLC22A3 gene polymorphisms are associated with reduced coronary artery disease risk in the male Chinese Han population.
abstract: Previous studies showed that PHACTR1 and SLC22A3 are involved in coronary vascular development and are key determinants of cardiovascular disease risk. We conducted a case-control study to examine the effect of SLC22A3 and PHACTR1 single nucleotide polymorphisms (SNPs) on CAD risk among 376 male CAD patients and 388 male healthy controls from China. Eleven SLC22A3 and PHACTR1 SNPs were selected and genotyped using Sequenom Mass-ARRAY technology. Odds ratios (OR) and 95% confidence intervals (CIs) were calculated using unconditional logistic regression adjusting for age. The rs9381439 minor allele "A" (OR = 0.72; 95% CI = 0.54-0.96; p = 0.024) in an allelic model was associated with reduced CAD risk, as were the rs2048327 "C/C" (OR = 0.60; 95% CI: 0.37-0.97; p = 0.036) and rs1810126 "T/T" (OR = 0.58; 95% CI: 0.36-0.93; p = 0.024) genotypes. Likewise, the rs9349379 "A/G" genotype in a dominant model (p = 0.041), the rs1810126 "T/C" genotype in additive (p = 0.041) and recessive (p = 0.012) models, and the rs2048327 "C/T" genotype in a recessive model were associated with decreased CAD risk (p = 0.016). These results suggest several PHACTR1 and SLC22A3 polymorphisms are associated with decreased CAD risk in the male Chinese Han population.
authors.affiliation: Department of Geratology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, China.
authors.forename: Qingbin
authors.initials: Q
authors.lastname: Zhao
authors.affiliation: Department of Geratology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, China.
authors.forename: Huiyi
authors.initials: H
authors.lastname: Wei
authors.affiliation: Department of Endocrinology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, China.
authors.forename: Dandan
authors.initials: D
authors.lastname: Liu
authors.affiliation: Inner Mongolia Medical University, Hohhot, Inner Mongolia, 010050, China.
authors.forename: Baolan
authors.initials: B
authors.lastname: Shi
authors.affiliation: Inner Mongolia Medical University, Hohhot, Inner Mongolia, 010050, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Li
authors.affiliation: School of Life Science, Northwest University, Xi'an, Shaanxi, 710069, China.
authors.forename: Mengdan
authors.initials: M
authors.lastname: Yan
authors.affiliation: Xi'an Tiangen Precision Medical Institute, Xi'an, Shaanxi 710075, China.
authors.forename: Xiyang
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Xi'an Tiangen Precision Medical Institute, Xi'an, Shaanxi 710075, China.
authors.forename: Fengjiao
authors.initials: F
authors.lastname: Wang
authors.affiliation: School of Life Science, Northwest University, Xi'an, Shaanxi, 710069, China.
authors.forename: Yongri
authors.initials: Y
authors.lastname: Ouyang
mesh_terms: D000368:Aged; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D003324:Coronary Artery Disease / Q000453:epidemiology* / Q000235:genetics*; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008840:Microfilament Proteins / Q000235:genetics*; D008875:Middle Aged; D016017:Odds Ratio; D027701:Organic Cation Transport Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012737:Sex Factors; D000099254:Organic Cation Transporter 3
chemical_list: D008840:Microfilament Proteins; D027701:Organic Cation Transport Proteins; D000099254:Organic Cation Transporter 3; C570134:PHACTR1 protein, human
keywords: PHACTR1; SLC22A3; case-control study; coronary artery disease (CAD); single nucleotide polymorphism (SNP)