title: The Newcastle Pediatric Mitochondrial Disease Scale: translation and cultural adaptation for use in Brazil.
abstract: OBJECTIVE
  The aim of this study was to translate and adapt the Newcastle Paediatric Mitochondrial Disease Scale (NPMDS) to Portuguese for use in Brazil.
  
  
  METHODS
  The scale was applied in 20 pediatric patients with mitochondrial disease, in three groups: myopathy (n = 4); Leigh syndrome (n = 8); and encephalomyopathy (n = 8). Scores were obtained for the various dimensions of the NPMDS, and comparisons were drawn between the groups.
  
  
  RESULTS
  There was a statistically significant difference between the myopathy group and the Leigh syndrome group (p = 0.0085), as well as between the myopathy and encephalomyopathy groups (p = 0.01).
  
  
  CONCLUSIONS
  The translation of the NPMDS, and its adaptation to the socioeconomic and cultural conditions in Brazil, make the NPMDS score useful as an additional parameter in the evaluation and monitoring of pediatric patients with MD in Brazil.
authors.affiliation: Universidade Federal de Minas Gerais, Faculdade de Medicina, Fisioterapeuta do Ambulatório de Doenças Neuromusculares HC/UFMG, Belo Horizonte MG, Brasil.
authors.forename: Gabriela Palhares
authors.initials: GP
authors.lastname: Campolina-Sampaio
authors.affiliation: Universidade Federal de Minas Gerais, Faculdade de Medicina, Departamento de Pediatria, Belo Horizonte MG, Brasil.
authors.forename: Laura Maria de Lima Belizário Facury
authors.initials: LM
authors.lastname: Lasmar
authors.affiliation: Universidade Federal de Minas Gerais, Hospital das Clínicas, Serviço de Neuropediatra, Belo Horizonte MG, Brasil.
authors.forename: Beatriz Silva Vilela
authors.initials: BS
authors.lastname: Ribeiro
authors.affiliation: Universidade Federal de Minas Gerais, Faculdade de Medicina, Departamento de Pediatria, Belo Horizonte MG, Brasil.
authors.forename: Juliana Gurgel
authors.initials: JG
authors.lastname: Giannetti
mesh_terms: D000293:Adolescent; D001938:Brazil; D002648:Child; D002675:Child, Preschool; D003431:Cross-Cultural Comparison; D003430:Cross-Sectional Studies; D018450:Disease Progression; D005260:Female; D006801:Humans; D007802:Language; D007888:Leigh Disease / Q000503:physiopathology; D008297:Male; D028361:Mitochondrial Diseases / Q000503:physiopathology*; D017237:Mitochondrial Encephalomyopathies / Q000503:physiopathology; D017240:Mitochondrial Myopathies / Q000503:physiopathology; D015203:Reproducibility of Results; D011795:Surveys and Questionnaires; D014177:Translations