title: Comprehensive review on various strategies for antimalarial drug discovery.
abstract: The resistance of malaria parasites to existing drugs carries on growing and progressively limiting our ability to manage this severe disease and finally lead to a massive global health burden. Till now, malaria control has relied upon the traditional quinoline, antifolate and artemisinin compounds. Very few new antimalarials were developed in the past 50 years. Among recent approaches, identification of novel chemotherapeutic targets, exploration of natural products with medicinal significance, covalent bitherapy having a dual mode of action into a single hybrid molecule and malaria vaccine development are explored heavily. The proper execution of these approaches and proper investment from international agencies will accelerate the discovery of drugs that provide new hope for the control or eventual eradication of this global infectious disease. This review explores various strategies for assessment and development of new antimalarial drugs. Current status and scientific value of previous approaches are systematically reviewed and new approaches provide a pragmatic forecast for future developments are introduced as well.
authors.affiliation: Department of Pharmaceutical Sciences, Dr. Harisingh Gour University (A Central University), Sagar, MP, India.
authors.forename: Mitali
authors.initials: M
authors.lastname: Mishra
authors.affiliation: Department of Pharmaceutical Sciences, Dr. Harisingh Gour University (A Central University), Sagar, MP, India.
authors.forename: Vikash K
authors.initials: VK
authors.lastname: Mishra
authors.affiliation: SVN Institute of Pharmaceutical Sciences, SVN University, Sagar, MP, India.
authors.forename: Varsha
authors.initials: V
authors.lastname: Kashaw
authors.affiliation: Use-inspired Biomaterials & Integrated Nano Delivery (U-BiND) Systems Laboratory, Department of Pharmaceutical Sciences, Wayne State University, Detroit, MI, USA.
authors.forename: Arun K
authors.initials: AK
authors.lastname: Iyer
authors.affiliation: Department of Pharmaceutical Sciences, Dr. Harisingh Gour University (A Central University), Sagar, MP, India; Use-inspired Biomaterials & Integrated Nano Delivery (U-BiND) Systems Laboratory, Department of Pharmaceutical Sciences, Wayne State University, Detroit, MI, USA. Electronic address: sushilkashaw@gmail.com.
authors.forename: Sushil Kumar
authors.initials: SK
authors.lastname: Kashaw
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D001688:Biological Products / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D055808:Drug Discovery / Q000379:methods*; D004351:Drug Resistance; D006801:Humans; D008288:Malaria / Q000188:drug therapy* / Q000378:metabolism / Q000517:prevention & control; D017780:Malaria Vaccines / Q000494:pharmacology / Q000627:therapeutic use; D058990:Molecular Targeted Therapy; D010961:Plasmodium / Q000187:drug effects* / Q000502:physiology
chemical_list: D000962:Antimalarials; D001688:Biological Products; D017780:Malaria Vaccines
keywords: Antimalarial; Drug resistance; Molecular targets; Plasmodium falciparum; Vaccine