title: [Therapeutic strategy targeting membrane molecular meshanosensing.]
abstract: Our bodies possess systems to detect various mechanical stimuli, called mechanosensing. Mechanosensing taking place in the membrane can be classified into to ion channel-dependent one and ion channel-independent one. Ion channel-dependent mechanosensing is a relatively rapid response, involving various mechanosen sensitive channels, including recently identified pannexin. In contrast, ion-channel-independent mechanosensing is a slow response, such as tissue remodeling, and the mechanism via integrin-actin interaction at the focal adhesion is well known.
authors.affiliation: Department of Bio-informational Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, Japan.
authors.forename: Tetsushi
authors.initials: T
authors.lastname: Furukawa
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000378:metabolism*; D017630:Connexins / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D007473:Ion Channels / Q000378:metabolism; D040542:Mechanotransduction, Cellular; D009419:Nerve Tissue Proteins / Q000737:chemistry / Q000378:metabolism
chemical_list: D017630:Connexins; D007473:Ion Channels; D009419:Nerve Tissue Proteins