title: Associations of nicotinamide N-methyltransferase gene single nucleotide polymorphisms with sport performance and relative maximal oxygen uptake.
abstract: To observe the associations between single nucleotide polymorphisms (SNPs) of nicotinamide N-methyltransferase (NNMT) gene and sport performance and to analyse genotype associations of the associated SNPs with sport performance and relative maximal oxygen uptake ([Formula: see text]). Participants were selected from 685 Chinese Han male college students. The completion times of a 1000-m run and a 50-m run were used to reflect sport performance, respectively. Nineteen tagSNPs were genotyped with Polymerase chain reaction-ligase detection reaction. Relative [Formula: see text] was directly determined with a cardiopulmonary function analyser. A significant association was found between rs2256292 and 1000-m run performance, but no significant association was found between any tagSNPs and 50-m run performance. The genotype associations of rs2256292 with 1000-m run performance and with relative [Formula: see text] were both significant under the recessive model (CC vs. CG + GG). No tagSNP in NNMT is significantly associated with 50-m run performance but rs2256292 is significantly associated with 1000-m run performance. The genotype associations of rs2256292 with sport performance are significant under recessive model, and a higher relative [Formula: see text] may be the physiological reason for minor homozygote CC carriers being of the better 1000-m runners.
authors.affiliation: a Key Laboratory of Training Monitoring and Intervention of Aquatic Sports of General Administration of Sport of China, Institute of Physical Education , Jiangxi Normal University , Nanchang , China.|b Key Laboratory of Functional Small Organic Molecule, Ministry of Education , Jiangxi Normal University , Nanchang , China.
authors.forename: Jiang-Hua
authors.initials: JH
authors.lastname: Li
authors.affiliation: a Key Laboratory of Training Monitoring and Intervention of Aquatic Sports of General Administration of Sport of China, Institute of Physical Education , Jiangxi Normal University , Nanchang , China.
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
authors.affiliation: a Key Laboratory of Training Monitoring and Intervention of Aquatic Sports of General Administration of Sport of China, Institute of Physical Education , Jiangxi Normal University , Nanchang , China.
authors.forename: Xiao-Juan
authors.initials: XJ
authors.lastname: Zhu
authors.affiliation: a Key Laboratory of Training Monitoring and Intervention of Aquatic Sports of General Administration of Sport of China, Institute of Physical Education , Jiangxi Normal University , Nanchang , China.
authors.forename: Ya-Jun
authors.initials: YJ
authors.lastname: Lin
authors.affiliation: a Key Laboratory of Training Monitoring and Intervention of Aquatic Sports of General Administration of Sport of China, Institute of Physical Education , Jiangxi Normal University , Nanchang , China.
authors.forename: Li-Qiang
authors.initials: LQ
authors.lastname: Qiu
authors.affiliation: a Key Laboratory of Training Monitoring and Intervention of Aquatic Sports of General Administration of Sport of China, Institute of Physical Education , Jiangxi Normal University , Nanchang , China.
authors.forename: Can-Xin
authors.initials: CX
authors.lastname: Cai
authors.affiliation: a Key Laboratory of Training Monitoring and Intervention of Aquatic Sports of General Administration of Sport of China, Institute of Physical Education , Jiangxi Normal University , Nanchang , China.
authors.forename: Ya-Hui
authors.initials: YH
authors.lastname: Wang
authors.affiliation: a Key Laboratory of Training Monitoring and Intervention of Aquatic Sports of General Administration of Sport of China, Institute of Physical Education , Jiangxi Normal University , Nanchang , China.
authors.forename: Qun
authors.initials: Q
authors.lastname: Xiong
authors.affiliation: a Key Laboratory of Training Monitoring and Intervention of Aquatic Sports of General Administration of Sport of China, Institute of Physical Education , Jiangxi Normal University , Nanchang , China.
authors.forename: Fei
authors.initials: F
authors.lastname: Chen
authors.affiliation: a Key Laboratory of Training Monitoring and Intervention of Aquatic Sports of General Administration of Sport of China, Institute of Physical Education , Jiangxi Normal University , Nanchang , China.
authors.forename: Li-Hui
authors.initials: LH
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D054874:Athletic Performance; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D050903:Nicotinamide N-Methyltransferase / Q000235:genetics*; D010101:Oxygen Consumption / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012420:Running; D013334:Students; D014495:Universities; D055815:Young Adult
chemical_list: D050903:Nicotinamide N-Methyltransferase
keywords: Sport performance; gene polymorphisms; genotypes; maximal oxygen uptake; nicotinamide N-methyltransferase