title: Epigenetic Impact on EBV Associated B-Cell Lymphomagenesis.
abstract: Epigenetic modifications leading to either transcriptional repression or activation, play an indispensable role in the development of human cancers. Epidemiological study revealed that approximately 20% of all human cancers are associated with tumor viruses. Epstein-Barr virus (EBV), the first human tumor virus, demonstrates frequent epigenetic alterations on both viral and host genomes in associated cancers-both of epithelial and lymphoid origin. The cell type-dependent different EBV latent gene expression patterns appear to be determined by the cellular epigenetic machinery and similarly viral oncoproteins recruit epigenetic regulators in order to deregulate the cellular gene expression profile resulting in several human cancers. This review elucidates the epigenetic consequences of EBV-host interactions during development of multiple EBV-induced B-cell lymphomas, which may lead to the discovery of novel therapeutic interventions against EBV-associated B-cell lymphomas by alteration of reversible patho-epigenetic markings.
authors.affiliation: Department of Life Sciences, Presidency University, 86/1, College Street, Kolkata 700073, West Bengal, India. shatadru54@gmail.com.
authors.forename: Shatadru
authors.initials: S
authors.lastname: Ghosh Roy
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, and the Tumor Virology Program, Abramson Comprehensive Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. erle@upenn.edu.
authors.forename: Erle S
authors.initials: ES
authors.lastname: Robertson
authors.affiliation: Department of Life Sciences, Presidency University, 86/1, College Street, Kolkata 700073, West Bengal, India. abhik.dbs@presiuniv.ac.in.
authors.forename: Abhik
authors.initials: A
authors.lastname: Saha
mesh_terms: D044127:Epigenesis, Genetic; D020031:Epstein-Barr Virus Infections / Q000453:epidemiology / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic; D015967:Gene Expression Regulation, Viral; D004854:Herpesvirus 4, Human / Q000235:genetics*; D006801:Humans; D016393:Lymphoma, B-Cell / Q000235:genetics / Q000821:virology*; D014764:Viral Proteins / Q000235:genetics
chemical_list: D014764:Viral Proteins
keywords: B-cell lymphoma; Epigenetics; Epstein-Barr virus