title: Dynamin Functions and Ligands: Classical Mechanisms Behind.
abstract: Dynamin is a GTPase that plays a vital role in clathrin-dependent endocytosis and other vesicular trafficking processes by acting as a pair of molecular scissors for newly formed vesicles originating from the plasma membrane. Dynamins and related proteins are important components for the cleavage of clathrin-coated vesicles, phagosomes, and mitochondria. These proteins help in organelle division, viral resistance, and mitochondrial fusion/fission. Dysfunction and mutations in dynamin have been implicated in the pathophysiology of various disorders, such as Alzheimer's disease, Parkinson's disease, Huntington's disease, Charcot-Marie-Tooth disease, heart failure, schizophrenia, epilepsy, cancer, dominant optic atrophy, osteoporosis, and Down's syndrome. This review is an attempt to illustrate the dynamin-related mechanisms involved in the above-mentioned disorders and to help medicinal chemists to design novel dynamin ligands, which could be useful in the treatment of dynamin-related disorders.
authors.affiliation: Department of Pharmacy, Birla Institute of Technology and Sciences Pilani, Pilani Campus, Rajasthan, India mahaveer2singh@gmail.com.
authors.forename: Mahaveer
authors.initials: M
authors.lastname: Singh
authors.affiliation: Department of Pharmacy, Birla Institute of Technology and Sciences Pilani, Pilani Campus, Rajasthan, India.
authors.forename: Hemant R
authors.initials: HR
authors.lastname: Jadhav
authors.affiliation: Department of Pharmacy, Birla Institute of Technology and Sciences Pilani, Pilani Campus, Rajasthan, India.
authors.forename: Tanya
authors.initials: T
authors.lastname: Bhatt
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D004194:Disease; D034281:Dynamins / Q000378:metabolism*; D004705:Endocytosis; D006801:Humans; D008024:Ligands; D058105:Polymerization
chemical_list: D008024:Ligands; D034281:Dynamins