title: Oleanolic acid suppresses vascular smooth muscle cell proliferation by increasing lincRNA-p21 expression.
abstract: Arteriosclerosis poses a significant risk to human health and involves the thickening and hardening of the walls of arteries. Accumulated evidence demonstrates that aberrant proliferation of vascular smooth muscle cells (VSMCs) accounts for the onset and progression of arteriosclerosis. Suppression of their proliferation has been demonstrated to be an effective anti-arteriosclerosis strategy. Long non-coding RNAs (lncRNAs) have recently been observed to be implicated in the proliferation of VSMCs and arteriosclerosis. In this study, we observed that oleanolic acid (OA), a natural compound from plants, inhibited the proliferation of VSMCs. The expression of lincRNA-p21, an arteriosclerosis-associated lncRNA, was demonstrated to be elevated by OA treatment. Suppression of lincRNA-p21 rescued the effect of OA on the proliferation of VSMCs. Collectively, targeting lncRNA is a promising strategy for arteriosclerosis prevention and treatment, and OA ameliorates arteriosclerosis by increasing lncRNA levels.
authors.affiliation: Department of General Medicine, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266031, P.R. China.
authors.forename: Di
authors.initials: D
authors.lastname: Han
authors.affiliation: Department of General Medicine, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266031, P.R. China.
authors.forename: Xuejuan
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of General Medicine, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266031, P.R. China.
authors.forename: Jietao
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of General Medicine, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266031, P.R. China.
authors.forename: Xiaozi
authors.initials: X
authors.lastname: Guo
authors.affiliation: Department of General Medicine, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266031, P.R. China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zheng
authors.affiliation: Department of Neurology, People's Hospital of Rizhao, Rizhao, Shandong 276800, P.R. China.
authors.forename: Shihua
authors.initials: S
authors.lastname: Sui
authors.affiliation: Department of Neurology, People's Hospital of Rizhao, Rizhao, Shandong 276800, P.R. China.
authors.forename: Jiaping
authors.initials: J
authors.lastname: Zheng
keywords: long non-coding RNA; oleanolic acid; vascular smooth muscle cell