title: Efficacy of Ifosfamide-Cisplatin-Etoposide (ICE) Chemotherapy for a CNS Germinoma in a Child With Down Syndrome.
abstract: Intracranial germ cell tumor is sometimes associated with Down syndrome; however, no optimal treatment has been developed due to the high risk of recurrence and treatment-related mortality. Here, we report on a patient with an intracranial germinoma in the bilateral basal ganglia. The patient received 3 courses of ifosfamide-cisplatin-etoposide in combination with whole-brain irradiation (24 Gy), with no serious complications. The patient is alive and disease free 16 months after the initial diagnosis. This regimen is a feasible treatment for intracranial germ cell tumor associated with Down syndrome, although careful attention must be paid to the increased risk for severe infection.
authors.affiliation: Departments of *Pediatrics †Neurosurgery ‡Radiation Oncology and Image-Applied Therapy §Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors.forename: Seishiro
authors.initials: S
authors.lastname: Nodomi
authors.forename: Katsutsugu
authors.initials: K
authors.lastname: Umeda
authors.forename: Hiroo
authors.initials: H
authors.lastname: Ueno
authors.forename: Satoshi
authors.initials: S
authors.lastname: Saida
authors.forename: Hidefumi
authors.initials: H
authors.lastname: Hiramatsu
authors.forename: Takeshi
authors.initials: T
authors.lastname: Funaki
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Arakawa
authors.forename: Takashi
authors.initials: T
authors.lastname: Mizowaki
authors.forename: Souichi
authors.initials: S
authors.lastname: Adachi
authors.forename: Toshio
authors.initials: T
authors.lastname: Heike
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D001479:Basal Ganglia / Q000000981:diagnostic imaging / Q000473:pathology; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects; D016371:Cranial Irradiation; D004314:Down Syndrome / Q000150:complications*; D005047:Etoposide / Q000008:administration & dosage / Q000009:adverse effects; D018237:Germinoma / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000532:radiotherapy; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage / Q000009:adverse effects; D008279:Magnetic Resonance Imaging; D008297:Male; D009503:Neutropenia / Q000139:chemically induced; D010291:Paresis / Q000209:etiology; D012074:Remission Induction; D015173:Supratentorial Neoplasms / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000532:radiotherapy
chemical_list: D005047:Etoposide; D002945:Cisplatin; D007069:Ifosfamide