title: Genetic variants in the acylphosphatase 2 gene and the risk of breast cancer in a Han Chinese population.
abstract: We performed a case-control study to investigate the associations between seven single nucleotide polymorphisms (SNPs) in the acylphosphatase 2 (ACYP2) gene and breast cancer (BC) risk in a Han Chinese population. There were 183 BC cases and 195 healthy controls included in the study. The SNPs were genotyped using the Sequenom MassARRAY platform. Logistic regression (adjusted for age group, body mass index [BMI], and menopause status), was used to evaluate the associations between the various genotypes and BC risk. Statistical analysis revealed that rs12621038 was associated with a decreased risk of BC in the allele (T vs. C: odds ratio [OR] = 0.71, 95% confidence interval [95% CI] = 0.52-0.94; p = 0.016), homozygous (TT vs. CC: OR = 0.47, 95% CI = 0.24-0.85; p = 0.014), dominant (OR = 0.62; 95% CI = 0.40-0.96; p = 0.032), and additive (OR = 0.68; 95% CI = 0.50-0.92; p = 0.012) models. In addition, we found that rs1682111 and rs17045754 were associated with the risk of BC and correlated with recurrence, and that rs6713088 correlated with tumor size. In sum, our findings reveal significant associations between SNPs in the ACYP2 gene and BC risk in a Han Chinese population.
authors.affiliation: Department of Oncology Surgery, Traditional Chinese Medicine Hospital of Xi'an, Xi'an, Shaanxi 710021, China.
authors.forename: Fuli
authors.initials: F
authors.lastname: Zhang
authors.affiliation: Department of Oncology Surgery, Traditional Chinese Medicine Hospital of Xi'an, Xi'an, Shaanxi 710021, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Breast Surgery, Tumor Hospital of Shaanxi Province, Xi'an 710061, China.
authors.forename: Zhiping
authors.initials: Z
authors.lastname: Deng
authors.affiliation: Inner Mongolia Medical University, Hohhot 010010, Inner Mongolia, China.
authors.forename: Pengcheng
authors.initials: P
authors.lastname: Xu
authors.affiliation: School of Life Sciences, Northwest University, Xi'an, Shaanxi 710069, China.
authors.forename: Xiyang
authors.initials: X
authors.lastname: Zhang
authors.affiliation: School of Life Sciences, Northwest University, Xi'an, Shaanxi 710069, China.|Key Laboratory of Resource Biology and Biotechnology, Ministry of Education, Northwest University, Xi'an, Shaanxi 710069, China.
authors.forename: Tianbo
authors.initials: T
authors.lastname: Jin
authors.affiliation: Department of Radiotherapy, Tumor Hospital of Shaanxi Province, Xi'an 710061, China.
authors.forename: Qiufang
authors.initials: Q
authors.lastname: Liu
mesh_terms: D017766:Acid Anhydride Hydrolases / Q000235:genetics*; D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics; D001943:Breast Neoplasms / Q000201:enzymology / Q000208:ethnology / Q000235:genetics*; D002681:China; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease / Q000208:ethnology / Q000235:genetics*; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D000097024:Acylphosphatase
chemical_list: D017766:Acid Anhydride Hydrolases; C000612927:ACYP2 protein, human; D000097024:Acylphosphatase
keywords: ACYP2; association study; breast cancer; single nucleotide polymorphism