title: Surveillance trends of carbapenem-resistant Enterobacteriaceae from Singapore, 2010-2013.
abstract: Trends in carbapenem-resistant Enterobacteriaceae (CRE) collected from hospitals nationwide in Singapore over 3 years are presented. Hospital isolates with imipenem or meropenem minimum inhibitory concentrations (MICs) of >1mg/L were sent to the National Public Health Laboratory for further investigation. A total of 400 CRE were submitted, 227 (56.8%) of which carried a carbapenemase gene. blaNDMwas the most common (130/400; 32.5%), followed by blaOXA-48-like(blaOXA-48, -181, -232) (55/400; 13.8%). Interestingly, four isolates bearing dual carbapenemase genes were also detected. KPC- and OXA-48-like-producing Klebsiella pneumoniae were fingerprinted by DiversiLab®rep-PCR. Locally, KPC producers do not appear to have clonal dissemination. In contrast, OXA-48-like producers were found to have a greater degree of clustering than KPC producers.
authors.affiliation: National University Health System, 5 Lower Kent Ridge Road, Singapore, 119074, Singapore. Electronic address: Jeanette_Teo@nuhs.edu.sg.
authors.forename: Jeanette W P
authors.initials: JW
authors.lastname: Teo
authors.affiliation: National Public Health Laboratory, Ministry of Health, Singapore.
authors.forename: Paul
authors.initials: P
authors.lastname: Tan
authors.affiliation: National Public Health Laboratory, Ministry of Health, Singapore.
authors.forename: My-Van
authors.initials: MV
authors.lastname: La
authors.affiliation: Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore 308433, Singapore.
authors.forename: Prabha
authors.initials: P
authors.lastname: Krishnan
authors.affiliation: KK Women's and Children's Hospital, 100 Bukit Timah Road, Singapore 229899, Singapore.
authors.forename: Nancy
authors.initials: N
authors.lastname: Tee
authors.affiliation: Singapore General Hospital, 20 College Road, Academia, Level 7, Diagnostics Tower, Singapore 169856, Singapore.
authors.forename: Tse Hsien
authors.initials: TH
authors.lastname: Koh
authors.affiliation: Khoo Teck Puat Hospital, 90 Yishun Central, Singapore 768828, Singapore.
authors.forename: Rama Narayana
authors.initials: RN
authors.lastname: Deepak
authors.affiliation: Changi General Hospital, 2 Simei Street 3, Singapore 529889, Singapore.
authors.forename: Thean Yen
authors.initials: TY
authors.lastname: Tan
authors.affiliation: National University Health System, 5 Lower Kent Ridge Road, Singapore, 119074, Singapore.
authors.forename: Roland
authors.initials: R
authors.lastname: Jureen
authors.affiliation: National University Health System, 5 Lower Kent Ridge Road, Singapore, 119074, Singapore; National Public Health Laboratory, Ministry of Health, Singapore.
authors.forename: Raymond T P
authors.initials: RT
authors.lastname: Lin
keywords: Antibiotic resistance; Carbapenemase; Clonality; Plasmid