title: A Case Report of Pregnancy During Use of Targeted Therapeutics for Cystic Fibrosis.
abstract: New therapeutics, such as ivacaftor, and the combination drug lumacaftor/ivacaftor that target the underlying genetic cause of cystic fibrosis are being hailed as game-changers in this era of personalized medicine. Although these drugs improve lung function, their effects on female fertility have not been studied. In this case report we describe one woman's experience with ivacaftor and her unanticipated pregnancy. Implications related to comprehensive sexual and reproductive health care for women with cystic fibrosis are presented.
authors.forename: Sigrid
authors.initials: S
authors.lastname: Ladores
authors.forename: Traci M
authors.initials: TM
authors.lastname: Kazmerski
authors.forename: Steven M
authors.initials: SM
authors.lastname: Rowe
mesh_terms: D000328:Adult; D000627:Aminophenols / Q000008:administration & dosage*; D000631:Aminopyridines / Q000008:administration & dosage*; D052117:Benzodioxoles / Q000008:administration & dosage*; D003550:Cystic Fibrosis / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D005260:Female; D006801:Humans; D057285:Precision Medicine; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D015363:Quinolones / Q000008:administration & dosage*
chemical_list: D000627:Aminophenols; D000631:Aminopyridines; D052117:Benzodioxoles; D004338:Drug Combinations; D015363:Quinolones; C000599212:lumacaftor, ivacaftor drug combination
keywords: cystic fibrosis; fertility; ivacaftor; lumacaftor/ivacaftor; sexual and reproductive health