title: Simultaneous 11C-Methionine Positron Emission Tomography/Magnetic Resonance Imaging of Suspected Primary Brain Tumors.
abstract: BACKGROUND
  The objective of this study was to assess the diagnostic value of integrated 11C- methionine PET/MRI for suspected primary brain tumors, in comparison to MRI alone.
  
  
  METHODS
  Forty-eight consecutive patients with suspected primary brain tumor were prospectively enrolled for an integrated 11C-methionine PET/MRI. Two neuro-radiologists separately evaluated the MRI alone and the integrated PET/MRI data sets regarding most likely diagnosis and diagnostic confidence on a 5-point scale. Reference standard was histopathology or follow-up imaging.
  
  
  RESULTS
  Fifty-one suspicious lesions were detected: 16 high-grade glioma and 25 low-grade glioma. Ten non-malignant cerebral lesions were described by the reference standard. MRI alone and integrated PET/MRI each correctly classified 42 of the 51 lesions (82.4%) as neoplastic lesions (WHO grade II, III and IV) or non-malignant lesions (infectious and neoplastic lesions). Diagnostic confidence for all lesions, low-grade astrocytoma and high-grade astrocytoma (3.7 vs. 4.2, 3,1 vs. 3.8, 4.0 vs. 4,7) were significantly (p < 0.05) better with integrated PET/MRI than in MRI alone.
  
  
  CONCLUSIONS
  The present study demonstrates the high potential of integrated 11C-methionine-PET/MRI for the assessment of suspected primary brain tumors. Although integrated methionine PET/MRI does not lead to an improvement of correct diagnoses, diagnostic confidence is significantly improved.
authors.affiliation: Institute of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Essen, Germany.|Erwin L. Hahn Institute for Magnetic Resonance Imaging, University of Duisburg-Essen, Essen, Germany.
authors.forename: Cornelius
authors.initials: C
authors.lastname: Deuschl
authors.affiliation: Institute of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Essen, Germany.
authors.forename: Sophia
authors.initials: S
authors.lastname: Goericke
authors.affiliation: Institute of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Essen, Germany.
authors.forename: Johannes
authors.initials: J
authors.lastname: Grueneisen
authors.affiliation: Institute of Diagnostic and Interventional Radiology, University Hospital Duesseldorf, Duesseldorf, Germany.
authors.forename: Lino Morris
authors.initials: LM
authors.lastname: Sawicki
authors.affiliation: Institute of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Essen, Germany.
authors.forename: Juliane
authors.initials: J
authors.lastname: Goebel
authors.affiliation: Department of Neurosurgery, University Hospital Essen, Essen, Germany.
authors.forename: Nicolai
authors.initials: N
authors.lastname: El Hindy
authors.affiliation: Department of Neurosurgery, University Hospital Essen, Essen, Germany.
authors.forename: Karsten
authors.initials: K
authors.lastname: Wrede
authors.affiliation: Department of Nuclear Medicine, University Hospital Essen, Essen, Germany.
authors.forename: Ina
authors.initials: I
authors.lastname: Binse
authors.affiliation: Department of Nuclear Medicine, University Hospital Essen, Essen, Germany.
authors.forename: Thorsten
authors.initials: T
authors.lastname: Poeppel
authors.affiliation: Erwin L. Hahn Institute for Magnetic Resonance Imaging, University of Duisburg-Essen, Essen, Germany.|High Field and Hybrid MR Imaging, University Hospital Essen, Essen, Germany.
authors.forename: Harald
authors.initials: H
authors.lastname: Quick
authors.affiliation: Institute of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Essen, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Forsting
authors.affiliation: Department of Medical Oncology, West German Cancer Center, University Hospital Essen, Essen, Germany.
authors.forename: Joerg
authors.initials: J
authors.lastname: Hense
authors.affiliation: Institute of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Essen, Germany.
authors.forename: Lale
authors.initials: L
authors.lastname: Umutlu
authors.affiliation: Institute of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Essen, Germany.|Department of Neuroradiology, University Hospital Giessen, Gießen, Germany.
authors.forename: Marc
authors.initials: M
authors.lastname: Schlamann
mesh_terms: D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D003287:Contrast Media / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008715:Methionine / Q000008:administration & dosage; D008875:Middle Aged; D064847:Multimodal Imaging; D011868:Radioisotopes / Q000008:administration & dosage; D014057:Tomography, X-Ray Computed
chemical_list: D003287:Contrast Media; D011868:Radioisotopes; D008715:Methionine