title: Tenosynovial giant cell tumors of the temporomandibular joint and lateral skull base: Review of 11 cases.
abstract: To elucidate the clinical behavior, treatment, and outcomes of tenosynovial giant cell tumors (TGCT) involving the temporomandibular joint (TMJ) and adjacent temporal bone.
  
  
  
  Retrospective case series with histopathologic review.
  
  
  
  A retrospective chart review was performed identifying and collecting data from all cases of TGCT involving the TMJ and adjacent temporal bone that were treated at the authors' center between January 1960 and December 2015.
  
  
  
  Eleven histopathologically confirmed cases met inclusion criteria. The median age at diagnosis was 49 years, eight patients were men, and the median follow-up was 116 months. Computed tomographic (CT) imaging revealed a lytic expansile mass centered on the TMJ. Magnetic resonance imaging (MRI) most commonly exhibited hypointense signal on precontrast T1- and T2-weighted sequences and variable postcontrast enhancement. The median delay in diagnosis was 24 months, and the most common presenting symptoms were hearing loss and pain. All patients underwent surgical resection, eight receiving gross total removal, one receiving near total removal, and two patients from early in the series receiving subtotal resection with neoadjuvant or adjuvant radiation. Histopathological review of surgical specimens revealed chondroid metaplasia in seven tumors. Eight of nine cases receiving gross total or near total resection have no evidence of recurrence to date.
  
  
  
  TGCT of the TMJ and temporal bone are rare and locally aggressive tumors that commonly present with nonspecific symptoms. A careful review of CT and MRI followed by early biopsy is critical in establishing an accurate diagnosis and facilitating appropriate treatment. TGCT of the TMJ more commonly contain chondroid metaplasia when compared to TGCT at other anatomic locations. Gross total resection is achievable in most cases and offers long-term cure. Radiation may be considered for recurrent disease or adjuvant therapy following subtotal resection.
  
  
  
  4. Laryngoscope, 127:2340-2346, 2017.
authors.affiliation: Department of Otorhinolaryngology, Mayo Clinic School of Medicine, Rochester, Minnesota, U.S.A.
authors.forename: Matthew L
authors.initials: ML
authors.lastname: Carlson
authors.affiliation: Department of Otorhinolaryngology, Mayo Clinic School of Medicine, Rochester, Minnesota, U.S.A.
authors.forename: L Mariel
authors.initials: LM
authors.lastname: Osetinsky
authors.affiliation: Department of Otorhinolaryngology, Mayo Clinic School of Medicine, Rochester, Minnesota, U.S.A.|Department of Otolaryngology-Head and Neck Surgery, Sheba Medical Center at Tel Hashomer, Tel Aviv, Israel.
authors.forename: Eran E
authors.initials: EE
authors.lastname: Alon
authors.affiliation: Radiology, Mayo Clinic School of Medicine, Rochester, Minnesota, U.S.A.
authors.forename: Carrie Y
authors.initials: CY
authors.lastname: Inwards
authors.affiliation: Radiology, Mayo Clinic School of Medicine, Rochester, Minnesota, U.S.A.
authors.forename: John I
authors.initials: JI
authors.lastname: Lane
authors.affiliation: Department of Otorhinolaryngology, Mayo Clinic School of Medicine, Rochester, Minnesota, U.S.A.
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Moore
mesh_terms: D000328:Adult; D001706:Biopsy; D003131:Combined Modality Therapy; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D000070779:Giant Cell Tumor of Tendon Sheath / Q000175:diagnosis* / Q000628:therapy; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D019291:Skull Base / Q000000981:diagnostic imaging*; D012888:Skull Neoplasms / Q000175:diagnosis* / Q000628:therapy; D013704:Temporomandibular Joint / Q000000981:diagnostic imaging*; D013705:Temporomandibular Joint Disorders / Q000175:diagnosis* / Q000628:therapy; D014057:Tomography, X-Ray Computed
keywords: Tenosynovial giant cell tumor; chondroblastoma; lateral skull base; mandible; pigmented villonodular synovitis; temporal bone; temporomandibular joint