title: Quantifying intraocular scatter with near diffraction-limited double-pass point spread function.
abstract: Measurement of the double-pass (DP) point-spread function (PSF) can provide an objective and non-invasive method for estimating intraocular scatter in the human eye. The objective scatter index (OSI), which is calculated from the DP PSF images, is commonly used to quantify intraocular scatter. In this article, we simulated the effect of higher-order ocular aberrations on OSI, and the results showed that higher-order ocular aberrations had a significant influence on OSI. Then we developed an adaptive optics DP PSF measurement system (AO-DPPMS) which was capable of correcting ocular aberrations up to eighth-order radial Zernike modes over a 6.0-mm pupil. Employing this system, we obtained DP PSF images of four subjects at the fovea. OSI values with aberrations corrected up to 2nd, 5th and 8th Zernike order were calculated respectively, from the DP PSF images of the four subjects. The experimental results were consistent with the simulation, suggesting that it is necessary to compensate for the higher-order ocular aberrations for accurate intraocular scatter estimation.
authors.affiliation: The Key Laboratory on Adaptive Optics, Chinese Academy of Sciences, Chengdu 610209, China; The Laboratory on Adaptive Optics, Institute of Optics and Electronics, Chinese Academy of Sciences, Chengdu 610209, China; University of Chinese Academy of Sciences, Beijing 100049, China.
authors.forename: Junlei
authors.initials: J
authors.lastname: Zhao
authors.affiliation: The Key Laboratory on Adaptive Optics, Chinese Academy of Sciences, Chengdu 610209, China; The Laboratory on Adaptive Optics, Institute of Optics and Electronics, Chinese Academy of Sciences, Chengdu 610209, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Xiao
authors.affiliation: The Key Laboratory on Adaptive Optics, Chinese Academy of Sciences, Chengdu 610209, China; The Laboratory on Adaptive Optics, Institute of Optics and Electronics, Chinese Academy of Sciences, Chengdu 610209, China; University of Chinese Academy of Sciences, Beijing 100049, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Kang
authors.affiliation: The Key Laboratory on Adaptive Optics, Chinese Academy of Sciences, Chengdu 610209, China; The Laboratory on Adaptive Optics, Institute of Optics and Electronics, Chinese Academy of Sciences, Chengdu 610209, China.
authors.forename: Haoxin
authors.initials: H
authors.lastname: Zhao
authors.affiliation: The Key Laboratory on Adaptive Optics, Chinese Academy of Sciences, Chengdu 610209, China; The Laboratory on Adaptive Optics, Institute of Optics and Electronics, Chinese Academy of Sciences, Chengdu 610209, China; daiyunqq@163.com.
authors.forename: Yun
authors.initials: Y
authors.lastname: Dai
authors.affiliation: The Key Laboratory on Adaptive Optics, Chinese Academy of Sciences, Chengdu 610209, China; The Laboratory on Adaptive Optics, Institute of Optics and Electronics, Chinese Academy of Sciences, Chengdu 610209, China; ydzhang@ioe.ac.cn.
authors.forename: Yudong
authors.initials: Y
authors.lastname: Zhang
keywords: (110.1080) Active or adaptive optics; (170.0110) Imaging systems; (170.4460) Ophthalmic optics and devices