title: Tissue ischemia worsens during hemodialysis in end-stage renal disease patients.
abstract: BACKGROUND
  Cognitive deficit is a common problem in end-stage renal disease (ESRD) patients. Ultrafiltration and hemodialysis lead to profound hemodynamic changes. The aim of this pilot study was to describe brain and hand oxygenation values in ESRD patients and their changes during hemodialysis.
  
  
  METHODS
  Twenty-seven patients treated by chronic hemodialysis and 17 controls patients of the same age were included in the study. Regional saturation of oxygen (SrO2) was measured at the brain frontal lobe and at the hand with dialysis access using the INVOS 5100C. In 17 of ESRD patients, SrO2 was also monitored throughout hemodialysis. Finger systolic blood pressure and basic hemodialysis and laboratory data were collected.
  
  
  RESULTS
  Dialysis patients had lower brain and also hand SrO2 values at rest (51.5 ± 10.9 vs. 68 ± 7%, p&lt;0.0001 and 55 ± 16 vs. 66 ± 8%, p = 0.03, respectively). Both values further decreased during the first 35 minutes of hemodialysis (brain SrO2 to 47 ± 8%, p&lt;0.0001 and hand to 45 ± 14%, p&lt;0.0001, respectively). The brain SrO2 decrease was related to the ultrafiltration rate, the hand SrO2 decrease to the finger pressure and to blood hemoglobin.
  
  
  CONCLUSIONS
  Chronic dialysis patients suffer from tissue ischemia and that even worsens after the beginning of hemodialysis. This observation may contribute to the understanding of cognitive deficit etiology.
authors.affiliation: 3rd Department of Internal Medicine, General University Hospital, First Faculty of Medicine, Charles University, Prague - Czech Republic.
authors.forename: Jan
authors.initials: J
authors.lastname: Malik
authors.affiliation: 3rd Department of Internal Medicine, General University Hospital, First Faculty of Medicine, Charles University, Prague - Czech Republic.
authors.forename: Jaroslav
authors.initials: J
authors.lastname: Kudlicka
authors.affiliation: Department of Nephrology, General University Hospital, First Faculty of Medicine, Charles University, Prague - Czech Republic.
authors.forename: Jana
authors.initials: J
authors.lastname: Lachmanova
authors.affiliation: 3rd Department of Internal Medicine, General University Hospital, First Faculty of Medicine, Charles University, Prague - Czech Republic.
authors.forename: Anna
authors.initials: A
authors.lastname: Valerianova
authors.affiliation: Department of Nephrology, General University Hospital, First Faculty of Medicine, Charles University, Prague - Czech Republic.
authors.forename: Katarina
authors.initials: K
authors.lastname: Rocinova
authors.affiliation: Department of Nephrology, General University Hospital, First Faculty of Medicine, Charles University, Prague - Czech Republic.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Bartkova
authors.affiliation: Department of Nephrology, General University Hospital, First Faculty of Medicine, Charles University, Prague - Czech Republic.
authors.forename: Vladimir
authors.initials: V
authors.lastname: Tesar
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D001783:Blood Flow Velocity; D002545:Brain Ischemia / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D016022:Case-Control Studies; D002560:Cerebrovascular Circulation; D003072:Cognition Disorders / Q000209:etiology / Q000503:physiopathology / Q000523:psychology; D005260:Female; D005625:Frontal Lobe / Q000098:blood supply*; D006225:Hand / Q000098:blood supply*; D006801:Humans; D007511:Ischemia / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D007676:Kidney Failure, Chronic / Q000175:diagnosis / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D010865:Pilot Projects; D012039:Regional Blood Flow; D006435:Renal Dialysis / Q000009:adverse effects*; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D010100:Oxygen