title: Abnormal wound healing related to high-dose systemic corticosteroid therapy in a patient with Ehlers-Danlos syndrome benign hypermobility Type.
abstract: The adverse impact of chronic corticosteroid therapy on wound healing has been well characterized, as has abnormal wound healing known to occur in the classic type of Ehlers-Danlos syndrome (EDS). In contrast, abnormal wound healing is absent in cases of EDS benign hypermobility type (EDS-BHT). We present the case of a patient with EDS-BHT with no history of abnormal wound healing who developed large nonhealing ulcers to sites of minor trauma after initiating therapy with high-dose systemic corticosteroids for dermatomyositis. This case provides a dramatic illustration of the effects of chronic systemic corticosteroids on skin fragility and wound healing in a patient with an underlying genetic defect of the connective tissue.
authors.affiliation: Ohio State University, Columbus, USA.
authors.forename: Stephanie K
authors.initials: SK
authors.lastname: Jacks
authors.affiliation: Ohio State University, Columbus, USA.
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Zirwas
mesh_terms: D003882:Dermatomyositis / Q000150:complications / Q000188:drug therapy*; D004535:Ehlers-Danlos Syndrome / Q000150:complications*; D004550:Elbow; D005938:Glucocorticoids / Q000009:adverse effects*; D006229:Hand Dermatoses; D006801:Humans; D007717:Knee; D008297:Male; D009205:Myocarditis / Q000150:complications / Q000188:drug therapy; D011241:Prednisone / Q000009:adverse effects*; D012883:Skin Ulcer / Q000503:physiopathology*; D014945:Wound Healing; D055815:Young Adult
chemical_list: D005938:Glucocorticoids; D011241:Prednisone