title: Flexible synthesis of cationic peptide-porphyrin derivatives for light-triggered drug delivery and photodynamic therapy.
abstract: Efficient syntheses of cell-penetrating peptide-porphyrin conjugates are described using a variety of bioconjugation chemistries. This provides a flexible means to convert essentially hydrophobic tetrapyrolle photosensitisers into amphiphilic derivatives which are well-suited for use in light-triggered drug delivery by photochemical internalisation (PCI) and targeted photodynamic therapy (PDT).
authors.affiliation: Department of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, UK. ie203@bath.ac.uk.
authors.forename: R
authors.initials: R
authors.lastname: Dondi
authors.affiliation: UCL Division of Surgery and Interventional Science, University College London, Royal Free Campus, Rowland Hill Street, London NW3 2PF, UK.
authors.forename: E
authors.initials: E
authors.lastname: Yaghini
authors.affiliation: Department of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, UK. ie203@bath.ac.uk.
authors.forename: K M
authors.identifier: http://orcid.org/0000-0001-7384-7112
authors.initials: KM
authors.lastname: Tewari
authors.affiliation: Department of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, UK. ie203@bath.ac.uk and School of Pharmaceutical Sciences, Shandong University, Jinan, China.
authors.forename: L
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, UK. ie203@bath.ac.uk.
authors.forename: F
authors.initials: F
authors.lastname: Giuntini
authors.affiliation: UCL Division of Surgery and Interventional Science, University College London, Royal Free Campus, Rowland Hill Street, London NW3 2PF, UK.
authors.forename: M
authors.initials: M
authors.lastname: Loizidou
authors.affiliation: UCL Division of Surgery and Interventional Science, University College London, Royal Free Campus, Rowland Hill Street, London NW3 2PF, UK.
authors.forename: A J
authors.initials: AJ
authors.lastname: MacRobert
authors.affiliation: Department of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, UK. ie203@bath.ac.uk.
authors.forename: I M
authors.initials: IM
authors.lastname: Eggleston
mesh_terms: D023181:Antimicrobial Cationic Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D016503:Drug Delivery Systems; D008027:Light; D015394:Molecular Structure; D010640:Phenothiazines / Q000138:chemical synthesis* / Q000737:chemistry; D010778:Photochemotherapy; D011166:Porphyrins / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D023181:Antimicrobial Cationic Peptides; D010640:Phenothiazines; D011166:Porphyrins