title: Biological Activity of Spirocyclic Hydroxamic Acids.
abstract: Iron-chelating activity of synthesized spirocyclic hydroxamic acids, their toxicity, and effects on mitochondrial function were studied using primary culture of cerebral cortical neurons from newborn rats. All tested compounds effectively chelated Fe(II) ions. Activity of spirocyclic hydroxamic acids more strictly depended on the structure their piperidine, but not imidazolidine fragment. All compounds were non-toxic for normal neuronal culture.
authors.affiliation: Institute of Problems of Chemical Physics, Russian Academy of Sciences, Chernogolovka, Russia. neganova83@mail.ru.
authors.forename: M E
authors.initials: ME
authors.lastname: Neganova
authors.affiliation: Institute of Problems of Chemical Physics, Russian Academy of Sciences, Chernogolovka, Russia.
authors.forename: D V
authors.initials: DV
authors.lastname: Mishchenko
authors.affiliation: Institute of Physiologically Active Compounds, Russian Academy of Sciences, Chernogolovka, Russia.
authors.forename: T P
authors.initials: TP
authors.lastname: Serkova
authors.affiliation: Institute of Problems of Chemical Physics, Russian Academy of Sciences, Chernogolovka, Russia.
authors.forename: I V
authors.initials: IV
authors.lastname: Vystorop
authors.affiliation: Institute of Physiologically Active Compounds, Russian Academy of Sciences, Chernogolovka, Russia.
authors.forename: E F
authors.initials: EF
authors.lastname: Shevtsova
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D021461:Animals, Outbred Strains; D002413:Cations, Divalent; D002470:Cell Survival / Q000187:drug effects; D002540:Cerebral Cortex / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D005297:Ferrozine / Q000737:chemistry; D006877:Hydroxamic Acids / Q000138:chemical synthesis / Q000494:pharmacology*; D007501:Iron / Q000378:metabolism*; D007502:Iron Chelating Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D008297:Male; D053078:Membrane Potential, Mitochondrial / Q000187:drug effects; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000378:metabolism; D008933:Mitochondrial Swelling / Q000187:drug effects; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism; D061251:Primary Cell Culture; D051381:Rats; D013141:Spiro Compounds / Q000138:chemical synthesis / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D002413:Cations, Divalent; D006877:Hydroxamic Acids; D007502:Iron Chelating Agents; D013141:Spiro Compounds; D005297:Ferrozine; D007501:Iron
keywords: chelators; hydroxamic acids; mitochondria; toxicity