title: Long-range synchrony and emergence of neural reentry.
abstract: Neural synchronization across long distances is a functionally important phenomenon in health and disease. In order to access the basis of different modes of long-range synchrony, we monitor spiking activities over centimetre scale in cortical networks and show that the mode of synchrony depends upon a length scale, λ, which is the minimal path that activity should propagate through to find its point of origin ready for reactivation. When λ is larger than the physical dimension of the network, distant neuronal populations operate synchronously, giving rise to irregularly occurring network-wide events that last hundreds of milliseconds to several seconds. In contrast, when λ approaches the dimension of the network, a continuous self-sustained reentry propagation emerges, a regular seizure-like mode that is marked by precise spatiotemporal patterns ('synfire chains') and may last many minutes. Termination of a reentry phase is preceded by a decrease of propagation speed to a halt. Stimulation decreases both propagation speed and λ values, which modifies the synchrony mode respectively. The results contribute to the understanding of the origin and termination of different modes of neural synchrony as well as their long-range spatial patterns, while hopefully catering to manipulation of the phenomena in pathological conditions.
authors.affiliation: Network Biology Research Laboratory, Electrical Engineering, Technion- Israel Institute of Technology, Haifa 3200003, Israel.|Department of Physiology, Biophysics and Systems Biology, Technion - Israel Institute of Technology, Haifa 32000, Israel.
authors.forename: Hanna
authors.initials: H
authors.lastname: Keren
authors.affiliation: Network Biology Research Laboratory, Electrical Engineering, Technion- Israel Institute of Technology, Haifa 3200003, Israel.|Department of Physiology, Biophysics and Systems Biology, Technion - Israel Institute of Technology, Haifa 32000, Israel.
authors.forename: Shimon
authors.initials: S
authors.lastname: Marom
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D058787:GABA-A Receptor Antagonists / Q000494:pharmacology; D008959:Models, Neurological; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D009435:Synaptic Transmission / Q000187:drug effects
chemical_list: D058787:GABA-A Receptor Antagonists