title: [Food protein-induced enterocolitis syndrome: A case report of diarrhea with hypovolemic shock and methemoglobinemia].
abstract: We report on the case of a young infant with chronic diarrhea that worsened and turned into hypovolemic shock with methemoglobinemia. We underline and discuss the main features of food protein-induced enterocolitis syndrome (FPIES). FPIES is a non-IgE-mediated food allergy involving tumor necrosis factor-alpha (TNF-α). Many triggering foods exist but cow's milk, as in the case reported herein, is one of the most frequent. It can start early or be delayed and start around the average age of 5 months. Symptoms are nonspecific with diarrhea and vomiting, but in the presence of methemoglobinemia, the diagnosis must be seriously considered. The oral food challenge remains the gold standard to confirm the diagnosis if there is still a doubt. Treatment of FPIES associates emergency treatment of acute dehydration with the prevention of relapses by avoiding the suspected protein.
authors.affiliation: Service de gastroentérologie hépatologie et nutrition pédiatrique, hospices civils de Lyon, hôpital Femme-Mère-Enfant du CHU de Lyon, 59, boulevard Pinel, 69677 Bron cedex, France.
authors.forename: L
authors.initials: L
authors.lastname: Genere
authors.affiliation: Service de gastroentérologie hépatologie et nutrition pédiatrique, hospices civils de Lyon, hôpital Femme-Mère-Enfant du CHU de Lyon, 59, boulevard Pinel, 69677 Bron cedex, France; Faculté de médecine Lyon-Est, université Claude-Bernard Lyon 1, 69003 Lyon, France.
authors.forename: N
authors.initials: N
authors.lastname: Pecciarini
authors.affiliation: Service de gastroentérologie hépatologie et nutrition pédiatrique, hospices civils de Lyon, hôpital Femme-Mère-Enfant du CHU de Lyon, 59, boulevard Pinel, 69677 Bron cedex, France; Faculté de médecine Lyon-Est, université Claude-Bernard Lyon 1, 69003 Lyon, France.
authors.forename: N
authors.initials: N
authors.lastname: Peretti
authors.affiliation: Service de gastroentérologie hépatologie et nutrition pédiatrique, hospices civils de Lyon, hôpital Femme-Mère-Enfant du CHU de Lyon, 59, boulevard Pinel, 69677 Bron cedex, France.
authors.forename: F
authors.initials: F
authors.lastname: Villard
authors.affiliation: Service de gastroentérologie hépatologie et nutrition pédiatrique, hospices civils de Lyon, hôpital Femme-Mère-Enfant du CHU de Lyon, 59, boulevard Pinel, 69677 Bron cedex, France; Faculté de médecine Lyon-Est, université Claude-Bernard Lyon 1, 69003 Lyon, France. Electronic address: alain.lachaux@chu-lyon.fr.
authors.forename: A
authors.initials: A
authors.lastname: Lachaux
mesh_terms: D003967:Diarrhea / Q000209:etiology; D004760:Enterocolitis / Q000209:etiology*; D005260:Female; D005512:Food Hypersensitivity / Q000150:complications*; D006801:Humans; D007223:Infant; D008708:Methemoglobinemia / Q000209:etiology; D008894:Milk Proteins / Q000009:adverse effects*; D012769:Shock / Q000209:etiology
chemical_list: D008894:Milk Proteins