title: Estimates of Radiation Effects on Cancer Risks in the Mayak Worker, Techa River and Atomic Bomb Survivor Studies.
abstract: For almost 50 y, the Life Span Study cohort of atomic bomb survivor studies has been the primary source of the quantitative estimates of cancer and non-cancer risks that form the basis of international radiation protection standards. However, the long-term follow-up and extensive individual dose reconstruction for the Russian Mayak worker cohort (MWC) and Techa River cohort (TRC) are providing quantitative information about radiation effects on cancer risks that complement the atomic bomb survivor-based risk estimates. The MWC, which includes ~26 000 men and women who began working at Mayak between 1948 and 1982, is the primary source for estimates of the effects of plutonium on cancer risks and also provides information on the effects of low-dose rate external gamma exposures. The TRC consists of ~30 000 men and women of all ages who received low-dose-rate, low-dose exposures as a consequence of Mayak's release of radioactive material into the Techa River. The TRC data are of interest because the exposures are broadly similar to those experienced by populations exposed as a consequence of nuclear accidents such as Chernobyl. In this presentation, it is described the strengths and limitations of these three cohorts, outline and compare recent solid cancer and leukemia risk estimates and discussed why information from the Mayak and Techa River studies might play a role in the development and refinement of the radiation risk estimates that form the basis for radiation protection standards.
authors.affiliation: Hirosoft International, 1335 H Street, Eureka, CA95501, USA.
authors.forename: Dale L
authors.initials: DL
authors.lastname: Preston
authors.affiliation: Epidemiology Laboratory Southern Urals Biophysics Institute, Ozyorskoe Schosse 19, Ozyorsk456780, Russian Federation.
authors.forename: Mikhail E
authors.initials: ME
authors.lastname: Sokolnikov
authors.affiliation: Epidemiology Laboratory, Urals Research Center for Radiation Medicine, 68-A Vorovsky Street, Chelyabinsk454076, Russian Federation.
authors.forename: Lyudmila Yu
authors.initials: LY
authors.lastname: Krestinina
authors.affiliation: Division of Biostatistics and Genetic Epidemiology, University of Southern California, Room 116, 2001 N Soto Street, Los Angeles, CA90033, USA.
authors.forename: Daniel O
authors.initials: DO
authors.lastname: Stram
mesh_terms: D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D009381:Neoplasms, Radiation-Induced / Q000453:epidemiology*; D054043:Nuclear Weapons; D012306:Risk; D012426:Russia; D017741:Survivors