title: Electrospinning versus microfluidic spinning of functional fibers for biomedical applications.
abstract: Micro- or nanofiber-based materials have extensive applications in biomedical fields due to their capability to mimic many aspects of physiological microenvironment in vivo. Fabricating micro- or nanofibers using biocompatible and biodegradable materials is becoming of great interest in the area of biomaterials and tissue engineering. Among the various technologies, electrospinning and microfluidic spinning are the two promising approaches to produce fibers at micro- and nano-scale. Choosing an appropriate spinning method is critical important for a specific application. Although some review papers on each spinning method have been published, a review comparing these two methods has not been reported yet. In this review, we present an overview of the two spinning methods including the spinning principle, their unique features and materials selections. Several applications of fibers spun by both methods, especially in tissue engineering, organ function regeneration and drug delivery are introduced. The current challenges, future directions and potential applications of these approaches are discussed as well.
authors.affiliation: School of Biomedical Engineering, College of Health Science, Korea University, Seoul, 02841, Republic of Korea.
authors.forename: Jie
authors.initials: J
authors.lastname: Cheng
authors.affiliation: KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul, 02841, Republic of Korea.
authors.forename: Yesl
authors.initials: Y
authors.lastname: Jun
authors.affiliation: Division of Biotechnology, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, China. Electronic address: jhqin@dicp.ac.cn.
authors.forename: Jianhua
authors.initials: J
authors.lastname: Qin
authors.affiliation: School of Biomedical Engineering, College of Health Science, Korea University, Seoul, 02841, Republic of Korea; KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul, 02841, Republic of Korea; Department of Bio-convergence Engineering, College of Health Science, Korea University, Seoul, 02841, Republic of Korea. Electronic address: dbiomed@korea.ac.kr.
authors.forename: Sang-Hoon
authors.initials: SH
authors.lastname: Lee
mesh_terms: D001672:Biocompatible Materials / Q000138:chemical synthesis*; D004339:Drug Compounding / Q000379:methods; D004595:Electroplating / Q000379:methods*; D008422:Materials Testing; D044085:Microfluidics / Q000379:methods*; D053769:Nanocapsules / Q000737:chemistry* / Q000648:ultrastructure*; D057139:Nanofibers / Q000737:chemistry* / Q000648:ultrastructure*; D012399:Rotation
chemical_list: D001672:Biocompatible Materials; D053769:Nanocapsules
keywords: Drug delivery; Electrospinning; Micro & nano fiber; Microfluidic spinning; Polymer; Tissue engineering