title: Crosstalk between Innate Lymphoid Cells and Other Immune Cells in the Tumor Microenvironment.
abstract: Our knowledge and understanding of the tumor microenvironment (TME) have been recently expanded with the recognition of the important role of innate lymphoid cells (ILC). Three different groups of ILC have been described based on their ability to produce cytokines that mediate the interactions between innate and adaptive immune cells in a variety of immune responses in infection, allergy, and autoimmunity. However, recent evidence from experimental models and clinical studies has demonstrated that ILC contribute to the mechanisms that generate suppressive or tolerant environments that allow tumor regression or progression. Defining the complex network of interactions and crosstalk of ILC with other immune cells and understanding the specific contributions of each type of ILC leading to tumor development will allow the manipulation of their function and will be important to develop new interventions and therapeutic strategies.
authors.affiliation: Breast Cancer Now Research Unit, Division of Cancer Studies, Guy's Hospital, King's College London School of Medicine, London SE1 9RT, UK.
authors.forename: Fabian
authors.identifier: 0000-0002-0881-8822
authors.initials: F
authors.lastname: Flores-Borja
authors.affiliation: Breast Cancer Now Research Unit, Division of Cancer Studies, Guy's Hospital, King's College London School of Medicine, London SE1 9RT, UK.
authors.forename: Sheeba
authors.initials: S
authors.lastname: Irshad
authors.affiliation: Breast Cancer Now Research Unit, Division of Cancer Studies, Guy's Hospital, King's College London School of Medicine, London SE1 9RT, UK.
authors.forename: Peter
authors.initials: P
authors.lastname: Gordon
authors.affiliation: Richard Dimbleby Department of Cancer Research, Randall Division & Division of Cancer Studies, King's College London, Guy's Medical School Campus, London SE1 1ULK, UK.
authors.forename: Felix
authors.initials: F
authors.lastname: Wong
authors.affiliation: Richard Dimbleby Department of Cancer Research, Randall Division & Division of Cancer Studies, King's College London, Guy's Medical School Campus, London SE1 1ULK, UK.
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Sheriff
authors.affiliation: Breast Cancer Now Research Unit, Division of Cancer Studies, Guy's Hospital, King's College London School of Medicine, London SE1 9RT, UK; Breast Cancer Now Toby Robins Research Centre, Institute of Cancer Research, London SW3 6JB, UK.
authors.forename: Andrew
authors.initials: A
authors.lastname: Tutt
authors.affiliation: Breast Cancer Now Research Unit, Division of Cancer Studies, Guy's Hospital, King's College London School of Medicine, London SE1 9RT, UK; Richard Dimbleby Department of Cancer Research, Randall Division & Division of Cancer Studies, King's College London, Guy's Medical School Campus, London SE1 1ULK, UK; UCL Cancer Institute, Paul O'Gorman Building, University College London, London WC1E 6DD, UK.
authors.forename: Tony
authors.initials: T
authors.lastname: Ng
mesh_terms: D000818:Animals; D015415:Biomarkers; D002450:Cell Communication / Q000276:immunology*; D002465:Cell Movement; D058948:Cell Tracking / Q000379:methods; D006801:Humans; D007113:Immunity, Innate; D008213:Lymphocyte Activation; D016131:Lymphocyte Subsets / Q000276:immunology* / Q000378:metabolism; D009369:Neoplasms / Q000276:immunology* / Q000378:metabolism / Q000473:pathology*; D009928:Organ Specificity / Q000276:immunology; D059016:Tumor Microenvironment / Q000276:immunology*
chemical_list: D015415:Biomarkers