title: Successful Lung Transplantation From Hepatitis C Positive Donor to Seronegative Recipient.
abstract: Lung transplantation using RNA+ hepatitis C (HCV+) donors to seronegative recipients is not currently performed due to the very high risk of transmission. Previous reports have shown poor survival when this practice was applied. The emergence of new direct-acting antiviral drugs (DAA) suggests a high chance of sustained virologic response in immunocompetent patients. We report here successful transplantation of lungs from HCV+ donor to HCV- recipient. The recipient was an HCV- patient with chronic lung allograft dysfunction. Viral transmission occurred early posttransplant but excellent clinical outcomes were observed including elimination of HCV after 12 weeks of treatment using DAAs.
authors.affiliation: Toronto Lung Transplant Program, University Health Network, University of Toronto, Toronto, Canada.
authors.forename: B
authors.initials: B
authors.lastname: Khan
authors.affiliation: Toronto Lung Transplant Program, University Health Network, University of Toronto, Toronto, Canada.
authors.forename: L G
authors.identifier: 0000-0002-2693-8676
authors.initials: LG
authors.lastname: Singer
authors.affiliation: Toronto Multi-Organ Transplant Program, University of Toronto, Toronto, Canada.
authors.forename: L B
authors.initials: LB
authors.lastname: Lilly
authors.affiliation: Toronto Lung Transplant Program, University Health Network, University of Toronto, Toronto, Canada.
authors.forename: C
authors.initials: C
authors.lastname: Chaparro
authors.affiliation: Toronto Lung Transplant Program, University Health Network, University of Toronto, Toronto, Canada.
authors.forename: T
authors.initials: T
authors.lastname: Martinu
authors.affiliation: Toronto Lung Transplant Program, University Health Network, University of Toronto, Toronto, Canada.
authors.forename: S
authors.initials: S
authors.lastname: Juvet
authors.affiliation: Toronto Lung Transplant Program, University Health Network, University of Toronto, Toronto, Canada.
authors.forename: M
authors.initials: M
authors.lastname: Pipkin
authors.affiliation: Toronto Lung Transplant Program, University Health Network, University of Toronto, Toronto, Canada.
authors.forename: T K
authors.initials: TK
authors.lastname: Waddell
authors.affiliation: Toronto Lung Transplant Program, University Health Network, University of Toronto, Toronto, Canada.
authors.forename: S
authors.initials: S
authors.lastname: Keshavjee
authors.affiliation: Toronto Multi-Organ Transplant Program, University of Toronto, Toronto, Canada.
authors.forename: A
authors.initials: A
authors.lastname: Humar
authors.affiliation: Toronto Lung Transplant Program, University Health Network, University of Toronto, Toronto, Canada.
authors.forename: M
authors.initials: M
authors.lastname: Cypel
mesh_terms: D000328:Adult; D006085:Graft Survival; D016174:Hepacivirus / Q000502:physiology; D006526:Hepatitis C / Q000517:prevention & control* / Q000635:transmission / Q000821:virology; D006801:Humans; D016040:Lung Transplantation / Q000379:methods*; D008297:Male; D008875:Middle Aged; D014019:Tissue Donors; D009927:Tissue and Organ Procurement; D066027:Transplant Recipients
keywords: clinical research/practice; complication: infectious; donors and donation: donor-derived infections; donors and donation: extended criteria; infectious disease; lung disease; lung transplantation/pulmonology; organ procurement and allocation; translational research/science