title: The Pressure of Aging.
abstract: Significant hemodynamic changes ensue with aging, leading to an ever-growing epidemic of hypertension. Alterations in central arterial properties play a major role in these hemodynamic changes. These alterations are characterized by an initial decline in aortic distensibility and an increase of diastolic blood pressure, followed by a sharp increase in pulse wave velocity (PWV), and an increase in pulse pressure (PP) beyond the sixth decade. However, the trajectories of PWV and PP diverge with advancing age. There is an increased prevalence of salt-sensitive hypertension with advancing age that is, in part, mediated by marinobufagenin, an endogenous sodium pump ligand.
authors.affiliation: Laboratory of Cardiovascular Science, NIA, NIH, Baltimore, MD, USA; Department of Medicine, Johns Hopkins Bayview Medical Center, Johns Hopkins School of Medicine, Baltimore, MD, USA.
authors.forename: Majd
authors.initials: M
authors.lastname: AlGhatrif
authors.affiliation: Laboratory of Cardiovascular Science, NIA, NIH, Baltimore, MD, USA.
authors.forename: Mingyi
authors.initials: M
authors.lastname: Wang
authors.affiliation: Laboratory of Cardiovascular Science, NIA, NIH, Baltimore, MD, USA.
authors.forename: Olga V
authors.initials: OV
authors.lastname: Fedorova
authors.affiliation: Laboratory of Cardiovascular Science, NIA, NIH, Baltimore, MD, USA.
authors.forename: Alexei Y
authors.initials: AY
authors.lastname: Bagrov
authors.affiliation: Laboratory of Cardiovascular Science, NIA, NIH, Baltimore, MD, USA. Electronic address: LakattaE@grc.nia.nih.gov.
authors.forename: Edward G
authors.initials: EG
authors.lastname: Lakatta
mesh_terms: D000367:Age Factors; D000375:Aging / Q000502:physiology*; D001158:Arteries / Q000503:physiopathology*; D009320:Atrial Natriuretic Factor / Q000378:metabolism; D002018:Bufanolides / Q000378:metabolism; D006439:Hemodynamics; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D008024:Ligands; D009131:Muscle, Smooth, Vascular / Q000503:physiopathology*; D032389:Myocytes, Smooth Muscle / Q000502:physiology; D063177:Pulse Wave Analysis; D015398:Signal Transduction; D017673:Sodium Chloride, Dietary / Q000378:metabolism; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D059289:Vascular Stiffness
chemical_list: D002018:Bufanolides; D008024:Ligands; D017673:Sodium Chloride, Dietary; C093896:marinobufagenin; D009320:Atrial Natriuretic Factor; D000254:Sodium-Potassium-Exchanging ATPase
keywords: Age-dependent salt-sensitive hypertension; Aging; Angiotensin II; Arterial fibrosis; Arterial wall remodeling; Hemodynamics; Marinobufagenin; Pulse wave velocity