title: Biogenic synthesis of silver nanoparticles fromCassia fistula(Linn.):In vitroassessment of their antioxidant, antimicrobial and cytotoxic activities.
abstract: The present study reports on biogenic-synthesised silver nanoparticles (AgNPs) derived by treating Ag ions with an extract ofCassia fistulaleaf, a popular Indian medicinal plant found in natural habitation. The progress of biogenic synthesis was monitored time to time using a ultraviolet-visible spectroscopy. The effect of phytochemicals present inC. fistulaincluding flavonoids, tannins, phenolic compounds and alkaloids on the homogeneous growth of AgNPs was investigated by Fourier-transform infrared spectroscopy. The dynamic light scattering studies have revealed an average size and surface Zeta potential of the NPs as, -39.5 nm and -21.6 mV, respectively. The potential antibacterial and antifungal activities of the AgNPs were evaluated againstBacillus subtilis, Staphylococcus aureus, Candida kruseiiandTrichophyton mentagrophytes. Moreover, their strong antioxidant capability was determined by radical scavenging methods (1,1-diphenyl-2-picryl-hydrazil assay). Furthermore, the AgNPs displayed an effective cytotoxicity against A-431 skin cancer cell line by 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay, with the inhibitory concentration (IC50) predicted as, 92.2 ± 1.2 μg/ml. The biogenically derived AgNPs could find immense scope as antimicrobial, antioxidant and anticancer agents apart from their potential use in chemical sensors and translational medicine.
authors.affiliation: Department of Biochemistry, M.P.C. Autonomous College, Baripada 757 003, Odisha, India.
authors.forename: Yugal Kishore
authors.initials: YK
authors.lastname: Mohanta
authors.affiliation: Department of Zoology, North Orissa University, Baripada 757 003, Odisha, India.
authors.forename: Sujogya Kumar
authors.initials: SK
authors.lastname: Panda
authors.affiliation: Department of Biotechnology, Maulana Abul Kalam Azad University of Technology, Kolkata 700 064, West Bengal, India.
authors.forename: Kunal
authors.initials: K
authors.lastname: Biswas
authors.affiliation: Department of Physics, Jadavpur University, Kolkata 700 032, West Bengal, India.
authors.forename: Abiral
authors.initials: A
authors.lastname: Tamang
authors.affiliation: Department of Biotechnology, Maulana Abul Kalam Azad University of Technology, Kolkata 700 064, West Bengal, India.
authors.forename: Jaya
authors.initials: J
authors.lastname: Bandyopadhyay
authors.affiliation: Department of Computer Science and Engineering, Maulana Abul Kalam Azad University of Technology, Kolkata 700 064, West Bengal, India.
authors.forename: Debashis
authors.initials: D
authors.lastname: De
authors.affiliation: Department of Physics, Tezpur Central University, Tezpur 784 028, Assam, India.
authors.forename: Dambarudhar
authors.initials: D
authors.lastname: Mohanta
authors.affiliation: Department of Botany, North Orissa University, Baripada 757 003, Odisha, India. bastianou@gmail.com.
authors.forename: Akshaya Kumar
authors.initials: AK
authors.lastname: Bastia
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D002366:Cassia / Q000737:chemistry*; D045744:Cell Line, Tumor; D006801:Humans; D053768:Metal Nanoparticles; D010936:Plant Extracts / Q000494:pharmacology*; D012834:Silver
chemical_list: D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D000975:Antioxidants; D010936:Plant Extracts; D012834:Silver