title: Fold formation at the compartment boundary of Drosophila wing requires Yki signaling to suppress JNK dependent apoptosis.
abstract: Compartment boundaries prevent cell populations of different lineage from intermingling. In many cases, compartment boundaries are associated with morphological folds. However, in the Drosophila wing imaginal disc, fold formation at the anterior/posterior (A/P) compartment boundary is suppressed, probably as a prerequisite for the formation of a flat wing surface. Fold suppression depends on optomotor-blind (omb). Omb mutant animals develop a deep apical fold at the A/P boundary of the larval wing disc and an A/P cleft in the adult wing. A/P fold formation is controlled by different signaling pathways. Jun N-terminal kinase (JNK) and Yorkie (Yki) signaling are activated in cells along the fold and are necessary for the A/P fold to develop. While JNK promotes cell shape changes and cell death, Yki target genes are required to antagonize apoptosis, explaining why both pathways need to be active for the formation of a stable fold.
authors.affiliation: Department of Entomology, China Agricultural University, 100193 Beijing, China.
authors.forename: Suning
authors.initials: S
authors.lastname: Liu
authors.affiliation: Department of Entomology, China Agricultural University, 100193 Beijing, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Sun
authors.affiliation: Department of Entomology, China Agricultural University, 100193 Beijing, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Wang
authors.affiliation: Institute of Genetics, Johannes Gutenberg-University, 55128 Mainz, Germany.
authors.forename: Gert O
authors.initials: GO
authors.lastname: Pflugfelder
authors.affiliation: Department of Entomology, China Agricultural University, 100193 Beijing, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Shen
mesh_terms: D000818:Animals; D017209:Apoptosis; D019521:Body Patterning / Q000502:physiology*; D029721:Drosophila Proteins / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000033:anatomy & histology / Q000254:growth & development* / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D060227:Imaginal Discs / Q000033:anatomy & histology / Q000254:growth & development* / Q000378:metabolism; D048670:MAP Kinase Kinase 4 / Q000378:metabolism*; D009687:Nuclear Proteins / Q000378:metabolism*; D015398:Signal Transduction; D015534:Trans-Activators / Q000378:metabolism*; D014921:Wings, Animal / Q000033:anatomy & histology / Q000254:growth & development* / Q000378:metabolism; D000091102:YAP-Signaling Proteins
chemical_list: D029721:Drosophila Proteins; D009687:Nuclear Proteins; D015534:Trans-Activators; D000091102:YAP-Signaling Proteins; C503814:Yki protein, Drosophila; D048670:MAP Kinase Kinase 4