title: Transplantation-associated thrombotic microangiopathy isolated to a congenital anomaly of the lung.
abstract: TA-TMA is a post-hematopoietic stem cell transplant complication with clinical features of hemolytic anemia and thrombocytopenia. A 26-month-old child who had had an allogeneic transplant for treatment of DBA developed severe TA-TMA with heavy red blood cell and platelet transfusion dependence. Incidentally, he was found to have a lung sequestration. TA-TMA resolved and transfusion dependence resolved after resection of the sequestration. The finding suggests the malformation vasculature was selectively vulnerable to the trigger of TA-TMA-raising perhaps a clue to basic pathophysiology of TA-TMA and/or vascular malformations.
authors.affiliation: Section of Pediatric Hematology/Oncology, Department of Pediatrics and Child Health, University of Manitoba and Health Sciences Centre, Winnipeg, Manitoba, Canada.
authors.forename: Rebecca T
authors.identifier: http://orcid.org/0000-0003-2099-0016
authors.initials: RT
authors.lastname: Kummen
authors.affiliation: Section of Pediatric Hematology/Oncology, Department of Pediatrics and Child Health, University of Manitoba and Health Sciences Centre, Winnipeg, Manitoba, Canada.|Manitoba Blood and Marrow Transplant Program, CancerCare Manitoba, Winnipeg, Manitoba, Canada.
authors.forename: Geoffrey D E
authors.initials: GD
authors.lastname: Cuvelier
authors.affiliation: Department of Pathology, University of Manitoba and Diagnostic Services of Manitoba, Health Sciences Centre, Winnipeg, Manitoba, Canada.
authors.forename: Camelia
authors.initials: C
authors.lastname: Stefanovici
authors.affiliation: Department of Pathology, University of Manitoba and Diagnostic Services of Manitoba, Health Sciences Centre, Winnipeg, Manitoba, Canada.
authors.forename: Anamarija M
authors.initials: AM
authors.lastname: Perry
authors.affiliation: Department of Radiology, University of Manitoba and Health Sciences Centre, Winnipeg, Manitoba, Canada.
authors.forename: Rick
authors.initials: R
authors.lastname: Higgins
authors.affiliation: Section of Pediatric Hematology/Oncology, Department of Pediatrics and Child Health, University of Manitoba and Health Sciences Centre, Winnipeg, Manitoba, Canada.
authors.forename: Rochelle
authors.initials: R
authors.lastname: Yanofsky
authors.affiliation: Department of Surgery, University of Manitoba and Health Sciences Centre, Winnipeg, Manitoba, Canada.
authors.forename: Suyin A
authors.initials: SA
authors.lastname: Lum Min
authors.affiliation: Section of Pediatric Hematology/Oncology, Department of Pediatrics and Child Health, University of Manitoba and Health Sciences Centre, Winnipeg, Manitoba, Canada.|Manitoba Blood and Marrow Transplant Program, CancerCare Manitoba, Winnipeg, Manitoba, Canada.|Department of Internal Medicine, University of Manitoba and Health Sciences Centre, Winnipeg, Manitoba, Canada.
authors.forename: Donna A
authors.initials: DA
authors.lastname: Wall
mesh_terms: D002675:Child, Preschool; D017707:Erythrocyte Transfusion; D004912:Erythrocytes; D006086:Graft vs Host Disease / Q000209:etiology*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D008168:Lung / Q000002:abnormalities*; D008171:Lung Diseases / Q000151:congenital*; D008297:Male; D017713:Platelet Transfusion; D057049:Thrombotic Microangiopathies / Q000209:etiology*; D014184:Transplantation, Homologous; D016896:Treatment Outcome
keywords: allogeneic stem cell transplantation; anemia; child; graft-vs-host disease; lung diseases; pediatric hematopoietic stem cell