title: Efficacy of zinc oxide nanoparticles in attenuating pancreatic damage in a rat model of streptozotocin-induced diabetes.
abstract: Zinc oxide nanoparticles (ZnO NPs) therapy is a promising strategy for treatment of several diseases. We aimed to investigate the therapeutic potential of ZnO NPs in ameliorating the histopathological and functional alterations in the pancreas of a rat model of streptozotocin-induced diabetes. Rats were randomized into control, diabetic and ZnO NPs-treated diabetic groups. Biochemical assays of blood glucose and serum insulin were performed. Pancreas specimens were processed for light and electron microscope examinations. ZnO NPs effectively reversed diabetes-induced pancreatic injury, as evidenced by the structural and ultrastructural improvement and confirmed by biochemical normalization of blood glucose and serum insulin.
authors.affiliation: a Department of Histology and Cell Biology, Faculty of Medicine , Zagazig University , Zagazig , Egypt.
authors.forename: Nashwa S
authors.initials: NS
authors.lastname: Wahba
authors.affiliation: a Department of Histology and Cell Biology, Faculty of Medicine , Zagazig University , Zagazig , Egypt.
authors.forename: Sahar F
authors.initials: SF
authors.lastname: Shaban
authors.affiliation: a Department of Histology and Cell Biology, Faculty of Medicine , Zagazig University , Zagazig , Egypt.
authors.forename: Asmaa A A
authors.initials: AA
authors.lastname: Kattaia
authors.affiliation: a Department of Histology and Cell Biology, Faculty of Medicine , Zagazig University , Zagazig , Egypt.
authors.forename: Sara A
authors.initials: SA
authors.lastname: Kandeel
mesh_terms: D000818:Animals; D003921:Diabetes Mellitus, Experimental; D053768:Metal Nanoparticles; D010179:Pancreas; D051381:Rats; D013311:Streptozocin; D015034:Zinc Oxide
chemical_list: D013311:Streptozocin; D015034:Zinc Oxide
keywords: Diabetes; histopathology; pancreas; rat; zinc oxide nanoparticles