title: Obesity-Related Digestive Diseases and Their Pathophysiology.
abstract: Obesity is a growing medical and public health problem worldwide. Many digestive diseases are related to obesity. In this article, the current state of our knowledge of obesity-related digestive diseases, their pathogenesis, and the medical and metabolic consequences of weight reduction are discussed. Obesity-related digestive diseases include gastroesophageal reflux disease, Barrett's esophagus, esophageal cancer, colon polyp and cancer, nonalcoholic fatty liver disease, hepatitis C-related disease, hepatocellular carcinoma, gallstone, cholangiocarcinoma, and pancreatic cancer. Although obesity-related esophageal diseases are associated with altered mechanical and humoral factors, other obesity-related digestive diseases seem to be associated with obesity-induced altered circulating levels of adipocytokines and insulin resistance. The relationship between functional gastrointestinal disease and obesity has been debated. This review provides a comprehensive evaluation of the obesity-related digestive diseases, including pathophysiology, obesity-related risk, and medical and metabolic effects of weight reduction in obese subjects.
authors.affiliation: Department of Gastroenterology, Gastric Cancer Center, Kyungpook National University Medical Center, Daegu, Korea.
authors.forename: Su Youn
authors.initials: SY
authors.lastname: Nam
mesh_terms: D054392:Adipokines / Q000097:blood; D004066:Digestive System Diseases / Q000209:etiology / Q000503:physiopathology*; D004935:Esophageal Diseases / Q000209:etiology / Q000503:physiopathology; D005767:Gastrointestinal Diseases / Q000209:etiology / Q000503:physiopathology; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D009765:Obesity / Q000150:complications*; D012307:Risk Factors; D015431:Weight Loss / Q000502:physiology
chemical_list: D054392:Adipokines
keywords: Cytokines; Gastrointestinal disease; Obesity