title: Development of a Novel Milling System Using Supercritical Carbon Dioxide for Improvement of Dissolution Characteristics of Water-Poorly Soluble Drugs.
abstract: The aim of this study is to develop a novel milling system using supercritical carbon dioxide (SC-CO2) for the improvement of dissolution characteristics of water-poorly soluble drugs. SC-CO2possesses high potential in the application of nanotechnology, due to the attractive properties of SC-CO2fluid such as cheap, inert and non-polluting. In addition, SC-CO2has density comparable to a liquid, viscosity similar to a gas, and high diffusion capacity. Most of all, carbon dioxide exists as gas in room temperature and pressure, which enables the removal of fluid instantaneously. In this study, a novel method of milling using SC-CO2was proposed to produce fine-drug particles. SC-CO2milling was conducted and its performance was compared with the ones by various milling methods such as jet milling, dry milling and wet milling. A comparison on the effect of each milling medium on its milling performance, drug size distribution, and particle morphology was conducted. Operating variables of the SC-CO2milling system were also investigated to clarify the factors affecting the milling properties and to improve drug release characteristics of water-poorly soluble drugs.
authors.affiliation: Department of Chemical Engineering, Osaka Prefecture University.
authors.forename: Jennifer Chia Wee
authors.initials: JC
authors.lastname: Fern
authors.forename: Hideya
authors.initials: H
authors.lastname: Nakamura
authors.forename: Satoru
authors.initials: S
authors.lastname: Watano
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry*; D002245:Carbon Dioxide / Q000737:chemistry*; D007213:Indomethacin / Q000737:chemistry*; D010316:Particle Size; D011312:Pressure; D012995:Solubility; D013499:Surface Properties; D013696:Temperature; D014867:Water / Q000737:chemistry*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D014867:Water; D002245:Carbon Dioxide; D007213:Indomethacin