title: Myoinositol and D-Chiro Inositol in Improving Insulin Resistance in Obese Male Children: Preliminary Data.
abstract: Myoinositol and D-chiro inositol, which are inositol isomers, have been shown to possess insulin-mimetic properties and to improve insulin resistance, especially in women with polycystic ovary syndrome. However, it has not been determined if this relationship exists also in children. Based on these previous findings, we hypothesized that inositol could be effective in improving insulin sensitivity in children with insulin resistance. To evaluate this hypothesis, we administered both inositol formulations before carrying out an oral glucose tolerance test (OGTT) in a group of obese insulin-resistant male children with high basal insulin levels and compared the values obtained with an OGTT previously conducted without inositol, in the same group, with unchanged BMI. Our results confirm that myoinositol and D-chiro inositol acutely reduce insulin increase after glucose intake mainly in children with high basal insulin level.
authors.affiliation: Pediatrics and Adolescent Andrological Project, Department of Pediatrics, San Paolo Hospital, Via di Rudini 8, University of Milan, 20142 Milan, Italy.
authors.forename: Mario
authors.identifier: 0000-0001-9082-449X
authors.initials: M
authors.lastname: Mancini
authors.affiliation: Pediatrics and Adolescent Andrological Project, Department of Pediatrics, San Paolo Hospital, Via di Rudini 8, University of Milan, 20142 Milan, Italy.
authors.forename: Alice
authors.initials: A
authors.lastname: Andreassi
authors.affiliation: Pediatrics and Adolescent Andrological Project, Department of Pediatrics, San Paolo Hospital, Via di Rudini 8, University of Milan, 20142 Milan, Italy.
authors.forename: Michela
authors.initials: M
authors.lastname: Salvioni
authors.affiliation: Pediatrics and Adolescent Andrological Project, Department of Pediatrics, San Paolo Hospital, Via di Rudini 8, University of Milan, 20142 Milan, Italy.
authors.forename: Fiore
authors.initials: F
authors.lastname: Pelliccione
authors.affiliation: Pediatrics and Adolescent Andrological Project, Department of Pediatrics, San Paolo Hospital, Via di Rudini 8, University of Milan, 20142 Milan, Italy.
authors.forename: Gianna
authors.initials: G
authors.lastname: Mantellassi
authors.affiliation: Pediatrics and Adolescent Andrological Project, Department of Pediatrics, San Paolo Hospital, Via di Rudini 8, University of Milan, 20142 Milan, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Banderali