title: Genetics and epigenetics of melanoma.
abstract: Cancer affects multiple organs in the body Malignant melanoma involves the invasion of skin and occasionally mucosal membrane or eye choroidal tissues. The incidence of cutaneous malignant melanoma is on the increase worldwide and is a major concern in current research. The increase is associated with UV irradiation-induced genetic aberrations that stimulate skin melanocytes to develop unlimited growth. This eventually leads to cell immortality, which in turn causes metastases. The present review examines the genetics and epigenetics of this pathological state together with recent perspectives of the therapeutic management of disease.
authors.affiliation: Information Technology Institute, Nanjing, Jiangsu 221009, P.R. China.
authors.forename: Xiao-Ying
authors.initials: XY
authors.lastname: Zhang
authors.affiliation: Department of Cardiology, Xuzhou Central Hospital, The Affiliated Xuzhou Hospital of Medical College of Southeast University, Xuzhou, Jiangsu 221009, P.R. China.
authors.forename: Pei-Ying
authors.initials: PY
authors.lastname: Zhang
keywords: epigenetics; genetics; melanoma