title: IL-6 roles - Molecular pathway and clinical implication in pancreatic cancer - A systemic review.
abstract: Pancreatic cancer has attracted a great deal of attention owing to the poor outcome, increasing prevalence in the last years and delay diagnosis. Known as a complex disease, it involves genetic mutations, changes in tumour microenvironment and inflammatory component dominated by interleukin-6 and its activated pathways, like Janus Kinase-Signal Transducer and Activator of Translation3, Mitogen Activated Protein Kinase and Androgen receptor. The pro-inflammatory cytokine, plays a central role in oncogenesis, cancer progression, invasiveness, microenvironment changes, treatment resistance, prognosis and associated co morbidities like cachexia and depression. Fulfilling these roles IL-6 requires special attention to understand its complexity in PC development.
authors.affiliation: Iuliu Hatieganu University of Medicine and Pharmacy, Dept. Of Immunology and Allergology, Cluj-Napoca, Romania.
authors.forename: Vlad-Vasile
authors.initials: VV
authors.lastname: Pop
authors.affiliation: Iuliu Hatieganu University of Medicine and Pharmacy, Dept. Of Internal Medicine, Gastroenterology, Cluj-Napoca, Romania; Octavian Fodor Regional Institute of Gastroenterology and Hepatology, Cluj-Napoca, Romania.
authors.forename: Andrada
authors.initials: A
authors.lastname: Seicean
authors.affiliation: Babes Bolyai University, Department of Molecular Biology, Cluj-Napoca, Romania.
authors.forename: Iulia
authors.initials: I
authors.lastname: Lupan
authors.affiliation: Iuliu Hatieganu University of Medicine and Pharmacy, Dept. Of Immunology and Allergology, Cluj-Napoca, Romania; Emergency Hospital for Children, Cluj-Napoca, Romania. Electronic address: Gabriel.Samasca@umfcluj.ro.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Samasca
authors.affiliation: Iuliu Hatieganu University of Medicine and Pharmacy, Dept. Of Immunology and Allergology, Cluj-Napoca, Romania; Ion Chiricuta Institute of Oncology, Cluj-Napoca, Romania.
authors.forename: Claudia-Cristina
authors.initials: CC
authors.lastname: Burz
mesh_terms: D006801:Humans; D014408:Biomarkers, Tumor; D015972:Gene Expression Regulation, Neoplastic; D015850:Interleukin-6 / Q000235:genetics / Q000378:metabolism; D010190:Pancreatic Neoplasms / Q000188:drug therapy / Q000378:metabolism / Q000401:mortality / Q000473:pathology; D011379:Prognosis; D015398:Signal Transduction; D014157:Transcription Factors / Q000378:metabolism; D059016:Tumor Microenvironment / Q000235:genetics
chemical_list: D014408:Biomarkers, Tumor; D015850:Interleukin-6; D014157:Transcription Factors
keywords: Interleukin-6; Oncogenesis; Pancreatic cancer; Prognosis