title: A singular limit for an age structured mutation problem.
abstract: The spread of a particular trait in a cell population often is modelled by an appropriate system of ordinary differential equations describing how the sizes of subpopulations of the cells with the same genome change in time. On the other hand, it is recognized that cells have their own vital dynamics and mutations, leading to changes in their genome, mostly occurring during the cell division at the end of its life cycle. In this context, the process is described by a system of McKendrick type equations which resembles a network transport problem. In this paper we show that, under an appropriate scaling of the latter, these two descriptions are asymptotically equivalent.
authors.affiliation: Department of Mathematics and Applied Mathematics, University of Pretoria, Pretoria, South Africa. email: jacek.banasiak@p.lodz.pl.
authors.forename: Jacek
authors.initials: J
authors.lastname: Banasiak
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Falkiewicz
mesh_terms: D000367:Age Factors; D002455:Cell Division; D008954:Models, Biological; D009154:Mutation; D010641:Phenotype