title: Optical Microbubble Resonators with High Refractive Index Inner Coating for Bio-Sensing Applications: An Analytical Approach.
abstract: The design of Whispering Gallery Mode Resonators (WGMRs) used as an optical transducer for biosensing represents the first and crucial step towards the optimization of the final device performance in terms of sensitivity and Limit of Detection (LoD). Here, we propose an analytical method for the design of an optical microbubble resonator (OMBR)-based biosensor. In order to enhance the OMBR sensing performance, we consider a polymeric layer of high refractive index as an inner coating for the OMBR. The effect of this layer and other optical/geometrical parameters on the mode field distribution, sensitivity and LoD of the OMBR is assessed and discussed, both for transverse electric (TE) and transverse magnetic (TM) polarization. The obtained results do provide physical insights for the development of OMBR-based biosensor.
authors.affiliation: Istituto di Fisica Applicata Nello Carrara (CNR IFAC), Via Madonna del Piano 10, 50019 Sesto Fiorentino, Firenze, Italy. a.barucci@ifac.cnr.it.
authors.forename: Andrea
authors.initials: A
authors.lastname: Barucci
authors.affiliation: Istituto di Fisica Applicata Nello Carrara (CNR IFAC), Via Madonna del Piano 10, 50019 Sesto Fiorentino, Firenze, Italy. s.berneschi@ifac.cnr.it.
authors.forename: Simone
authors.initials: S
authors.lastname: Berneschi
authors.affiliation: Istituto di Fisica Applicata Nello Carrara (CNR IFAC), Via Madonna del Piano 10, 50019 Sesto Fiorentino, Firenze, Italy. a.giannetti@ifac.cnr.it.
authors.forename: Ambra
authors.initials: A
authors.lastname: Giannetti
authors.affiliation: Istituto di Fisica Applicata Nello Carrara (CNR IFAC), Via Madonna del Piano 10, 50019 Sesto Fiorentino, Firenze, Italy. f.baldini@ifac.cnr.it.
authors.forename: Francesco
authors.initials: F
authors.lastname: Baldini
authors.affiliation: Istituto di Fisica Applicata Nello Carrara (CNR IFAC), Via Madonna del Piano 10, 50019 Sesto Fiorentino, Firenze, Italy. a.cosci@ifac.cnr.it.|Centro Studi e Ricerche «E. Fermi» Piazza del Viminale 1, 00184 Rome, Italy. a.cosci@ifac.cnr.it.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Cosci
authors.affiliation: Istituto di Fisica Applicata Nello Carrara (CNR IFAC), Via Madonna del Piano 10, 50019 Sesto Fiorentino, Firenze, Italy. s.pelli@ifac.cnr.it.|Centro Studi e Ricerche «E. Fermi» Piazza del Viminale 1, 00184 Rome, Italy. s.pelli@ifac.cnr.it.
authors.forename: Stefano
authors.initials: S
authors.lastname: Pelli
authors.affiliation: Istituto di Fisica Applicata Nello Carrara (CNR IFAC), Via Madonna del Piano 10, 50019 Sesto Fiorentino, Firenze, Italy. d.farnesi@ifac.cnr.it.|Centro Studi e Ricerche «E. Fermi» Piazza del Viminale 1, 00184 Rome, Italy. d.farnesi@ifac.cnr.it.
authors.forename: Daniele
authors.initials: D
authors.lastname: Farnesi
authors.affiliation: Istituto di Fisica Applicata Nello Carrara (CNR IFAC), Via Madonna del Piano 10, 50019 Sesto Fiorentino, Firenze, Italy. giancarlo.righini@centrofermi.it.|Centro Studi e Ricerche «E. Fermi» Piazza del Viminale 1, 00184 Rome, Italy. giancarlo.righini@centrofermi.it.
authors.forename: Giancarlo C
authors.initials: GC
authors.lastname: Righini
authors.affiliation: Istituto di Fisica Applicata Nello Carrara (CNR IFAC), Via Madonna del Piano 10, 50019 Sesto Fiorentino, Firenze, Italy. s.soria@ifac.cnr.it.
authors.forename: Silvia
authors.initials: S
authors.lastname: Soria
authors.affiliation: Istituto di Fisica Applicata Nello Carrara (CNR IFAC), Via Madonna del Piano 10, 50019 Sesto Fiorentino, Firenze, Italy. g.nunziconti@ifac.cnr.it.
authors.forename: Gualtiero
authors.initials: G
authors.lastname: Nunzi Conti
mesh_terms: D015374:Biosensing Techniques / Q000379:methods*; D057230:Limit of Detection; D045423:Microbubbles; D011108:Polymers / Q000737:chemistry; D012031:Refractometry
chemical_list: D011108:Polymers
keywords: high refractive index polymer; optical microbubble resonator; optical modeling; whispering gallery mode resonators