title: Intralocus sexual conflict and insecticide resistance.
abstract: The BA allele of the Drosophila cytochrome P450 gene Cyp6g1 confers resistance to a range of insecticides. It is also subject to intralocus sexual conflict when introgressed into the Canton-S background, whose collection predates the widespread use of insecticides. In this genetic background, the allele confers a pleiotropic fitness benefit to females but a cost to males, and exhibits little sexual dimorphism in conferred insecticide resistance. It is unclear whether these sexually antagonistic effects also exist in current populations that have naturally evolved with insecticides, where genetic modifiers that offset male costs might be expected to evolve. Here, we explore these issues using Drosophila melanogaster caught recently from an Australian population in which the BA allele naturally segregates. While we find increased fecundity in insecticide-resistant BA females and no consistent evidence of fitness costs in males, experimental evolution indicates balancing selection at the locus. We suggest that this apparent discrepancy may be due to reduced investment in reproduction in resistant males. Our results at the population level are consistent with previous work, and suggest that individual-level fitness assays do not always capture sexually antagonistic fitness effects that emerge in a population context.
authors.affiliation: Centre for Ecology and Conservation, University of Exeter, Tremough, Penryn TR10 9FE, UK.
authors.forename: M F
authors.identifier: 0000-0001-8762-995X
authors.initials: MF
authors.lastname: Hawkes
authors.affiliation: Centre for Ecology and Conservation, University of Exeter, Tremough, Penryn TR10 9FE, UK.
authors.forename: C E
authors.initials: CE
authors.lastname: Gamble
authors.affiliation: Centre for Ecology and Conservation, University of Exeter, Tremough, Penryn TR10 9FE, UK.
authors.forename: E C R
authors.initials: EC
authors.lastname: Turner
authors.affiliation: Centre for Ecology and Conservation, University of Exeter, Tremough, Penryn TR10 9FE, UK.
authors.forename: M R
authors.initials: MR
authors.lastname: Carey
authors.affiliation: Centre for Ecology and Conservation, University of Exeter, Tremough, Penryn TR10 9FE, UK.
authors.forename: N
authors.initials: N
authors.lastname: Wedell
authors.affiliation: Centre for Ecology and Conservation, University of Exeter, Tremough, Penryn TR10 9FE, UK d.j.hosken@exeter.ac.uk.
authors.forename: D J
authors.initials: DJ
authors.lastname: Hosken
mesh_terms: D000483:Alleles; D000818:Animals; D001315:Australia; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics; D029721:Drosophila Proteins / Q000235:genetics; D004331:Drosophila melanogaster / Q000235:genetics*; D005260:Female; D005298:Fertility; D056084:Genetic Fitness; D058685:Genetic Pleiotropy; D007305:Insecticide Resistance / Q000235:genetics*; D008297:Male; D012727:Sex Characteristics
chemical_list: D029721:Drosophila Proteins; D003577:Cytochrome P-450 Enzyme System; C446928:Cyp6g1 protein, Drosophila
keywords: Cyp6g1; insecticide resistance; sexual conflict