title: Application of Multiplex Biomarker Approaches to Accelerate Drug Discovery and Development.
abstract: Multiplex biomarker tests are becoming an essential part of the drug development process. This chapter explores the role of biomarker-based tests as effective tools in improving preclinical research and clinical development, and the challenges that this presents. The potential of incorporating biomarkers in the clinical pipeline to improve decision making, accelerate drug development, improve translation, and reduce development costs is discussed. This chapter also discusses the latest biomarker technologies in use to make this possible and details the next steps that must undertaken to keep driving this process forwards.
authors.affiliation: Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, CB2 3RA, UK. hr228@cam.ac.uk.
authors.forename: Hassan
authors.initials: H
authors.lastname: Rahmoune
authors.affiliation: Laboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, SP, Brazil.
authors.forename: Paul C
authors.initials: PC
authors.lastname: Guest
mesh_terms: D000818:Animals; D015415:Biomarkers; D000068456:Clinical Studies as Topic; D055808:Drug Discovery / Q000379:methods / Q000592:standards; D004353:Drug Evaluation, Preclinical; D023281:Genomics / Q000379:methods; D006801:Humans; D055432:Metabolomics / Q000379:methods; D040901:Proteomics / Q000379:methods; D015203:Reproducibility of Results
chemical_list: D015415:Biomarkers
keywords: Biomarker; Drug discovery; Genomics; Metabolomics; Pharmaceutical company; Proteomics; Transcriptomics