title: Chemical Constituents of Phaius mishmensis.
abstract: The partitionedn-hexane, CHCl₃, and EtOAc extracts from the crude MeOH extract ofPhaius mishmensisshowed considerable cytotoxicities against the human breast carcinoma (MCF-7), lung carcinoma (NCI-H460), and central nervous system carcinoma (SF-268) cell lines. Four new compounds, phaindole (1), (7'R,8'R)-phaithrene (2), methyl 3-hydroxy-4,5-dimethoxypropiophenone (3), and methyl hematinate (4), as well as 44 known compounds were isolated from the MeOH extract ofPhaius mishmensis. The structures of the compounds were determined using spectroscopic methods.
authors.affiliation: Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan. foxrain.tw@msa.hinet.net.
authors.forename: Chen-Wei
authors.initials: CW
authors.lastname: Jao
authors.affiliation: School of Pharmacy, China Medical University, Taichung 40402, Taiwan. u103003093@cmu.edu.tw.
authors.forename: Tzu-Heng
authors.initials: TH
authors.lastname: Hung
authors.affiliation: Department of Anatomy, School of Medicine, China Medical University, Taichung 40402, Taiwan. cfchang@mail.cmu.edu.tw.
authors.forename: Chi-Fen
authors.initials: CF
authors.lastname: Chang
authors.affiliation: School of Pharmacy, China Medical University, Taichung 40402, Taiwan. thchuang@mail.cmu.edu.tw.|Research Center for Chinese Herbal Medicine, China Medical University, Taichung 40402, Taiwan. thchuang@mail.cmu.edu.tw.
authors.forename: Ta-Hsien
authors.initials: TH
authors.lastname: Chuang
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D017209:Apoptosis; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D061986:MCF-7 Cells; D015394:Molecular Structure; D029595:Orchidaceae / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts
keywords: (7′R,8′R)-phaithrene; Orchidaceae; Phaius mishmensis; methyl 3-hydroxy-4,5-dimethoxypropiophenone; methyl hematinate; phaindole