title: Abnormal Coupling Between Default Mode Network and Delta and Beta Band Brain Electric Activity in Psychotic Patients.
abstract: Common-phase synchronization of neuronal oscillations is a mechanism by which distributed brain regions can be integrated into transiently stable networks. Based on the hypothesis that schizophrenia is characterized by deficits in functional integration within neuronal networks, this study aimed to explore whether psychotic patients exhibit differences in brain regions involved in integrative mechanisms. We report an electroencephalography (EEG)-informed functional magnetic resonance imaging analysis of eyes-open resting-state data collected from patients and healthy controls at two study sites. Global field synchronization (GFS) was chosen as an EEG measure indicating common-phase synchronization across electrodes. Several brain clusters appeared to be coupled to GFS differently in patients and controls. Activation in brain areas belonging to the default mode network was negatively associated to GFS delta (1-3.5 Hz) and positively to GFS beta (13-30 Hz) bands in patients, whereas controls showed an opposite pattern for both GFS frequency bands in those regions; activation in the extrastriate visual cortex was inversely related to GFS alpha1 (8.5-10.5 Hz) band in healthy controls, while patients had a tendency toward a positive relationship. Taken together, the GFS measure might be useful for detecting additional aspects of deficient functional network integration in psychosis.
authors.affiliation: 1 Translational Research Center, University Hospital of Psychiatry, University of Bern , Bern, Switzerland .|2 Center for Cognition, Learning and Memory, University of Bern , Bern, Switzerland .
authors.forename: Anja
authors.initials: A
authors.lastname: Baenninger
authors.affiliation: 3 San Francisco VA Medical Center , San Francisco, California.
authors.forename: Vanessa A
authors.initials: VA
authors.lastname: Palzes
authors.affiliation: 3 San Francisco VA Medical Center , San Francisco, California.
authors.forename: Brian J
authors.initials: BJ
authors.lastname: Roach
authors.affiliation: 3 San Francisco VA Medical Center , San Francisco, California.|4 Department of Psychiatry, University of California San Francisco , San Francisco, California.
authors.forename: Daniel H
authors.initials: DH
authors.lastname: Mathalon
authors.affiliation: 3 San Francisco VA Medical Center , San Francisco, California.|4 Department of Psychiatry, University of California San Francisco , San Francisco, California.
authors.forename: Judith M
authors.initials: JM
authors.lastname: Ford
authors.affiliation: 1 Translational Research Center, University Hospital of Psychiatry, University of Bern , Bern, Switzerland .|2 Center for Cognition, Learning and Memory, University of Bern , Bern, Switzerland .
authors.forename: Thomas
authors.initials: T
authors.lastname: Koenig
mesh_terms: D000328:Adult; D001611:Beta Rhythm / Q000502:physiology*; D001921:Brain / Q000000981:diagnostic imaging / Q000503:physiopathology*; D001931:Brain Mapping; D016022:Case-Control Studies; D003700:Delta Rhythm / Q000502:physiology*; D004569:Electroencephalography; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D001523:Mental Disorders / Q000000981:diagnostic imaging / Q000473:pathology*; D008875:Middle Aged; D008959:Models, Neurological; D010100:Oxygen / Q000097:blood; D055815:Young Adult
chemical_list: D010100:Oxygen
keywords: EEG-informed fMRI analysis (or EEG-fMRI study); delta and beta bands; eyes-open resting state; functional network integration; global field synchronization; psychosis