title: The role of adipose tissue and excess of fatty acids in the induction of insulin resistance in skeletal muscle.
abstract: Skeletal muscle is the main tissue responsible for insulin-stimulated glucose uptake. Consumption of a high-fat diet rich in saturated fats (HFD) and obesity are associated with accumulation of intramuscular lipids that leads to several disorders, e.g. insulin resistance (IRes) and type 2 diabetes (T2D). The mechanism underlying the induction of IRes is still unknown. It was speculated that accumulation of intramuscular triacylglycerols (TAG) is linked to induction of IRes. Now, research focuses on bioactive lipids: long-chain acyl-CoA (LCACoA), diacylglycerols (DAG) and ceramides (Cer). It has been demonstrated that accumulation of each of the above-mentioned lipid classes negatively affects the insulin signaling pathway. It is not clear which of those lipids play the most important role in HFD-induced skeletal muscle IRes. The aim of the present work is to present the current knowledge of the role of adipose tissue and excess of fatty acids in the induction of insulin resistance.
authors.affiliation: Zakład Higieny, Epidemiologii i Zaburzeń Metabolicznych, Uniwersytet Medyczny w Białymstoku; NZOZ Specjalistyczny Ośrodek Medyczny "SOMED" Poradnia Diabetologiczna, Łomża.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Błachnio-Zabielska
authors.affiliation: NZOZ Specjalistyczny Ośrodek Medyczny "SOMED" Poradnia Diabetologiczna, Łomża.
authors.forename: Sławomir
authors.initials: S
authors.lastname: Grycel
authors.affiliation: Zakład Higieny, Epidemiologii i Zaburzeń Metabolicznych, Uniwersytet Medyczny w Białymstoku.
authors.forename: Marta
authors.initials: M
authors.lastname: Chacińska
authors.affiliation: Zakład Biologii Ogólnej, Uniwersytet Medyczny w Białymstoku, Białystok, Białystok.
authors.forename: Piotr
authors.initials: P
authors.lastname: Zabielski
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism* / Q000503:physiopathology; D000818:Animals; D002518:Ceramides / Q000378:metabolism / Q000502:physiology; D004075:Diglycerides / Q000378:metabolism / Q000502:physiology; D005227:Fatty Acids / Q000378:metabolism* / Q000502:physiology; D006801:Humans; D007328:Insulin; D007333:Insulin Resistance; D018482:Muscle, Skeletal / Q000378:metabolism* / Q000503:physiopathology; D015398:Signal Transduction
chemical_list: D002518:Ceramides; D004075:Diglycerides; D005227:Fatty Acids; D007328:Insulin