title: Human Immunodeficiency Virus/AIDS, Human Papillomavirus, and Anal Cancer.
abstract: Anal cancer is an increasingly common non-AIDS-defining cancer among individuals infected with the human immunodeficiency virus (HIV). It is associated with human papillomavirus (HPV). HPV16 is the most common genotype detected in anal cancers. The HPV types detected in anal cancer are included in the 9-valent vaccine. HPV vaccines have demonstrated efficacy in reducing anal precancerous lesions in HIV-infected individuals. Standard treatment has been fluorouracil and mitomycin (or cisplatin) plus radiation. Continued studies are needed to test new treatment strategies in HIV-infected patients with anal cancer to determine which treatment protocols provide the best therapeutic index.
authors.affiliation: Division of Hematology/Oncology, Department of Medicine, Zuckerberg San Francisco General Hospital, 995 Potrero Avenue, Building 80, 4th Floor, San Francisco, CA 94110, USA.
authors.forename: Chia-Ching J
authors.initials: CJ
authors.lastname: Wang
authors.affiliation: Department of Oncology, Montefiore Medical Center, Albert Einstein College of Medicine, 1695 Eastchester Road, Bronx, NY 10461, USA.
authors.forename: Joseph
authors.initials: J
authors.lastname: Sparano
authors.affiliation: Division of Infectious Diseases, Department of Medicine, University of California at San Francisco, 513 Parnassus Avenue, Medical Science Room 420E, Box 0654, San Francisco, CA 94143, USA. Electronic address: joel.palefsky@ucsf.edu.
authors.forename: Joel M
authors.initials: JM
authors.lastname: Palefsky
mesh_terms: D000163:Acquired Immunodeficiency Syndrome; D001003:Anal Canal / Q000821:virology; D001005:Anus Neoplasms / Q000453:epidemiology* / Q000821:virology; D006678:HIV; D006679:HIV Seropositivity / Q000453:epidemiology*; D006801:Humans; D016867:Immunocompromised Host; D007165:Immunosuppression Therapy; D027383:Papillomaviridae; D030361:Papillomavirus Infections / Q000453:epidemiology*; D053918:Papillomavirus Vaccines
chemical_list: D053918:Papillomavirus Vaccines
keywords: Anal cancer; HIV; HPV; HPV vaccination; Immunosuppression