title: Thermal therapy with magnetic nanoparticles for cell destruction.
abstract: In this article we suggest a new concept for cell destruction based upon manipulating magnetic nanoparticles (MNPs) by applying external, low frequency alternating magnetic field (AMF) that oscillates the particles, together with focused laser illumination. Assessment of temperature profiles in a head and neck squamous cell carcinoma sample showed that cells with MNPs, treated with AMF (3 Hz, 300 mW) and laser irradiation (30 mW), reached 42°C after 4.5 min, as opposed to cells treated with laser but without AMF. Moreover, a theoretical model was developed to assess the overall theoretical temperature rise, which was shown to be 50% lower than the experimental temperature. Furthermore, we found that the combination of laser irradiation and AMF decreased the number of live cells by ~50%. Thus, the concentrated assembly of laser heating with AMF-induced MNP oscillations leads to more rapid and efficient cell death. These results suggest that the manipulated MNP technique can serve as a superior agent for PTT, with improved cell death capabilities.
authors.affiliation: Faculty of Engineering & the Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat-Gan, Israel.
authors.forename: Adi
authors.initials: A
authors.lastname: Vegerhof
authors.affiliation: Faculty of Engineering & the Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat-Gan, Israel.
authors.forename: Menachem
authors.initials: M
authors.lastname: Motei
authors.affiliation: Faculty of Engineering & the Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat-Gan, Israel.
authors.forename: Arkady
authors.initials: A
authors.lastname: Rudinzky
authors.affiliation: Faculty of Engineering Holon Institute of Technology, Holon, Israel.
authors.forename: Dror
authors.initials: D
authors.lastname: Malka
authors.affiliation: Faculty of Engineering & the Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat-Gan, Israel.
authors.forename: Rachela
authors.initials: R
authors.lastname: Popovtzer
authors.affiliation: Faculty of Engineering & the Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat-Gan, Israel.
authors.forename: Zeev
authors.initials: Z
authors.lastname: Zalevsky
keywords: (140.3538) Lasers, pulsed; (140.7300) Visible lasers; (170.1420) Biology; (170.1470) Blood or tissue constituent monitoring; (170.1530) Cell analysis