title: Gut Homeostasis, Microbial Dysbiosis, and Opioids.
abstract: Gut homeostasis plays an important role in maintaining animal and human health. The disruption of gut homeostasis has been shown to be associated with multiple diseases. The mutually beneficial relationship between the gut microbiota and the host has been demonstrated to maintain homeostasis of the mucosal immunity and preserve the integrity of the gut epithelial barrier. Currently, rapid progress in the understanding of the host-microbial interaction has redefined toxicological pathology of opioids and their pharmacokinetics. However, it is unclear how opioids modulate the gut microbiome and metabolome. Our study, showing opioid modulation of gut homeostasis in mice, suggests that medical interventions to ameliorate the consequences of drug use/abuse will provide potential therapeutic and diagnostic strategies for opioid-modulated intestinal infections. The study of morphine's modulation of the gut microbiome and metabolome will shed light on the toxicological pathology of opioids and its role in the susceptibility to infectious diseases.
authors.affiliation: 1 Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, Saint Paul, Minnesota, USA.
authors.forename: Fuyuan
authors.initials: F
authors.lastname: Wang
authors.affiliation: 1 Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, Saint Paul, Minnesota, USA.|2 Department of Surgery, Medical School, University of Minnesota, Minneapolis, Minnesota, USA.
authors.forename: Sabita
authors.initials: S
authors.lastname: Roy
mesh_terms: D000701:Analgesics, Opioid / Q000633:toxicity*; D000818:Animals; D064806:Dysbiosis / Q000139:chemically induced* / Q000382:microbiology / Q000517:prevention & control; D006706:Homeostasis / Q000187:drug effects*; D006801:Humans; D018928:Immunity, Mucosal / Q000187:drug effects*; D007413:Intestinal Mucosa / Q000187:drug effects* / Q000276:immunology / Q000382:microbiology; D064307:Microbiota / Q000187:drug effects*; D056692:Prebiotics
chemical_list: D000701:Analgesics, Opioid; D056692:Prebiotics
keywords: dysbiosis; gut microbiota; homeostasis; opioid-related disorders