title: Donor IFNL4 Genotype Is Associated with Early Post-Transplant Fibrosis in Recipients with Hepatitis C.
abstract: OBJECTIVE
  Early post-transplant hepatic fibrosis is associated with poor outcomes and may be influenced by donor/recipient genetic factors. The rs368234815 IFNL4 polymorphism is related to the previously described IL28B polymorphism, which predicts etiology-independent hepatic fibrosis. The aim of this study was to identify the impact of donor and/or recipient IFNL4 genotype on early fibrosis among patients transplanted for hepatitis C (HCV).
  
  
  METHODS
  Clinical data were collected for 302 consecutive patients transplanted for HCV. 116 patients who had available liver biopsies and donor/recipient DNA were included. 28% of these patients with stage 2 fibrosis or greater were compared to patients without significant post-transplant fibrosis with respect to clinical features as well as donor/recipient IFNL4 genotype.
  
  
  RESULTS
  The IFNL4 TT/TT genotype was found in 26.0% of recipients and 38.6% of donors. Patients who developed early post-transplant fibrosis had a 3.45 adjusted odds of having donor IFNL4 TT/TT genotype (p = 0.012). Donor IFNL4 TT/TT genotype also predicted decreased overall survival compared to non-TT/TT genotypes (p = 0.016).
  
  
  CONCLUSIONS
  Donor IFNL4 TT/TT genotype, a favorable predictor of spontaneous HCV clearance pre-transplant, is associated with increased early post-transplant fibrosis and decreased survival.
authors.affiliation: Cleveland Clinic Lerner College of Medicine, Cleveland Clinic, Cleveland, Ohio, United States of America.
authors.forename: Taylor
authors.initials: T
authors.lastname: Aiken
authors.affiliation: Digestive Diseases Institute, Cleveland Clinic, Cleveland, Ohio, United States of America.
authors.forename: Ari
authors.initials: A
authors.lastname: Garber
authors.affiliation: Allogen Laboratories, Cleveland Clinic, Cleveland, Ohio, United States of America.
authors.forename: Dawn
authors.initials: D
authors.lastname: Thomas
authors.affiliation: Allogen Laboratories, Cleveland Clinic, Cleveland, Ohio, United States of America.
authors.forename: Nicole
authors.initials: N
authors.lastname: Hamon
authors.affiliation: Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio, United States of America.
authors.forename: Rocio
authors.initials: R
authors.lastname: Lopez
authors.affiliation: Virginia Commonwealth University School of Medicine, Richmond, Virginia, United States of America.
authors.forename: Rajesh
authors.initials: R
authors.lastname: Konjeti
authors.affiliation: Digestive Diseases Institute, Cleveland Clinic, Cleveland, Ohio, United States of America.
authors.forename: Arthur
authors.initials: A
authors.lastname: McCullough
authors.affiliation: Digestive Diseases Institute, Cleveland Clinic, Cleveland, Ohio, United States of America.
authors.forename: Nizar
authors.initials: N
authors.lastname: Zein
authors.affiliation: Digestive Diseases Institute, Cleveland Clinic, Cleveland, Ohio, United States of America.
authors.forename: John
authors.initials: J
authors.lastname: Fung
authors.affiliation: Transplant Immunology, Baylor University Medical Center, Dallas, Texas, United States of America.
authors.forename: Medhat
authors.initials: M
authors.lastname: Askar
authors.affiliation: Virginia Commonwealth University School of Medicine, Richmond, Virginia, United States of America.|Gastroenterology and Hepatology, Hunter Holmes McGuire VA Medical Center, Richmond, Virginia, United States of America.
authors.forename: Binu V
authors.initials: BV
authors.lastname: John
mesh_terms: D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D005838:Genotype; D019698:Hepatitis C, Chronic / Q000235:genetics / Q000401:mortality / Q000601:surgery; D006801:Humans; D007378:Interleukins / Q000235:genetics*; D008103:Liver Cirrhosis / Q000209:etiology / Q000235:genetics / Q000401:mortality; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D015996:Survival Rate; D014019:Tissue Donors; D000095022:Interferon Lambda
chemical_list: D007378:Interleukins; C579163:IFNL4 protein, human; D000095022:Interferon Lambda