title: A scored human protein-protein interaction network to catalyze genomic interpretation.
abstract: Genome-scale human protein-protein interaction networks are critical to understanding cell biology and interpreting genomic data, but challenging to produce experimentally. Through data integration and quality control, we provide a scored human protein-protein interaction network (InWeb_InBioMap, or InWeb_IM) with severalfold more interactions (>500,000) and better functional biological relevance than comparable resources. We illustrate that InWeb_InBioMap enables functional interpretation of >4,700 cancer genomes and genes involved in autism.
authors.affiliation: Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA.|Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.|Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
authors.forename: Taibo
authors.initials: T
authors.lastname: Li
authors.affiliation: Intomics A/S, Lyngby, Denmark.|Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby, Denmark.
authors.forename: Rasmus
authors.initials: R
authors.lastname: Wernersson
authors.affiliation: Intomics A/S, Lyngby, Denmark.
authors.forename: Rasmus B
authors.identifier: 0000-0002-5899-0356
authors.initials: RB
authors.lastname: Hansen
authors.affiliation: Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA.|Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.|Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Heiko
authors.initials: H
authors.lastname: Horn
authors.affiliation: Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA.|Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
authors.forename: Johnathan
authors.initials: J
authors.lastname: Mercer
authors.affiliation: Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby, Denmark.
authors.forename: Greg
authors.identifier: 0000-0001-6918-0386
authors.initials: G
authors.lastname: Slodkowicz
authors.affiliation: Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby, Denmark.
authors.forename: Christopher T
authors.initials: CT
authors.lastname: Workman
authors.affiliation: Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby, Denmark.
authors.forename: Olga
authors.initials: O
authors.lastname: Rigina
authors.affiliation: Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby, Denmark.
authors.forename: Kristoffer
authors.initials: K
authors.lastname: Rapacki
authors.affiliation: Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby, Denmark.
authors.forename: Hans H
authors.initials: HH
authors.lastname: Stærfeldt
authors.affiliation: Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Søren
authors.initials: S
authors.lastname: Brunak
authors.affiliation: Intomics A/S, Lyngby, Denmark.
authors.forename: Thomas S
authors.initials: TS
authors.lastname: Jensen
authors.affiliation: Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA.|Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.|Harvard Medical School, Boston, Massachusetts, USA.|Institute for Biological Psychiatry, Mental Health Center Sct. Hans, University of Copenhagen, Roskilde, Denmark.
authors.forename: Kasper
authors.initials: K
authors.lastname: Lage
mesh_terms: D019295:Computational Biology / Q000379:methods*; D003627:Data Interpretation, Statistical; D030562:Databases, Protein; D053263:Gene Regulatory Networks; D015894:Genome, Human; D023281:Genomics / Q000379:methods*; D006801:Humans; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism*; D060066:Protein Interaction Maps / Q000235:genetics*; D014584:User-Computer Interface