title: Peculiar Aspects in Influence of α1-Adrenoceptor Stimulation on Isolated Rat Heart.
abstract: The study examined the effect of α1-adrenoceptor stimulation with methoxamine on chronotropic function of isolated heart perfused ex vivo according to Langendorff and cardiac chronotropy in vivo. Stimulation of α1-adrenoceptors in isolated heart induced gradually developing bradycardia, which progressed during several minutes. Similar stimulation in vivo produced a short-term bradycardia probably terminated by the compensatory influences in the whole organism. Comparison of the data obtained in both experimental paradigms during α1-adrenoceptor stimulation revealed unidirectional changes in cardiac chronotropy characterized with time-related peculiarities.
authors.affiliation: Department of Human Health Protection, Kazan (Volga Region) Federal University, Kazan, the Republic of Tatarstan, Russia. zefirovtl@mail.ru.
authors.forename: T L
authors.initials: TL
authors.lastname: Zefirov
authors.affiliation: Department of Human Health Protection, Kazan (Volga Region) Federal University, Kazan, the Republic of Tatarstan, Russia.
authors.forename: I I
authors.initials: II
authors.lastname: Khabibrakhmanov
authors.affiliation: Department of Human Health Protection, Kazan (Volga Region) Federal University, Kazan, the Republic of Tatarstan, Russia.
authors.forename: N I
authors.initials: NI
authors.lastname: Ziyatdinova
authors.affiliation: Department of Normal Physiology, Kazan Federal Medical University, Kazan, the Republic of Tatarstan, Russia.
authors.forename: A L
authors.initials: AL
authors.lastname: Zefirov
mesh_terms: D058646:Adrenergic alpha-1 Receptor Agonists / Q000494:pharmacology*; D000818:Animals; D021461:Animals, Outbred Strains; D001919:Bradycardia / Q000139:chemically induced / Q000503:physiopathology*; D005260:Female; D006321:Heart / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects* / Q000502:physiology; D008297:Male; D008729:Methoxamine / Q000494:pharmacology*; D009200:Myocardial Contraction / Q000187:drug effects; D009924:Organ Culture Techniques; D051381:Rats; D018340:Receptors, Adrenergic, alpha-1 / Q000378:metabolism*; D013997:Time Factors
chemical_list: D058646:Adrenergic alpha-1 Receptor Agonists; D018340:Receptors, Adrenergic, alpha-1; D008729:Methoxamine
keywords: chronotropy; heart; methoxamine; rat; α1-adrenoceptor