title: Evaluating the role of maternal folic acid supplementation in modifying the effects of methylenetetrahydrofolate reductase (C677T and A1298C) gene polymorphisms in oral cleft children.
abstract: BACKGROUND
  We studied the role of maternal folic acid supplementation in modifying the effects of methylenetetrahydrofolate reductase (MTHFRC677T and A1298C) gene polymorphisms in Iranian children with oral clefts.
  
  
  METHODS
  Forty-seven newborn infants with orofacial cleft and their mothers were selected randomly. Mothers were matched regarding dietary folate intake. The genotyping on venous blood was carried out. Consistency between maternal and child genotypes was analyzed.
  
  
  RESULTS
  Genotype consistency was not statistically significant in both C677T and A1298C gene variants (P> 0.05).
  
  
  CONCLUSIONS
  Maternal folic acid consumption may not have any significant effect on modifying C677T and A1298C polymorphisms in children.
authors.affiliation: Dentofacial Deformities Research Center, Research Institute of Dental Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Asghar
authors.initials: A
authors.lastname: Ebadifar
authors.affiliation: Department of Orthodontic, Dental School, Semnan University of Medical Sciences, Semnan, Iran.
authors.forename: Nazila
authors.initials: N
authors.lastname: Ameli
authors.affiliation: Genetic Research Centre, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
authors.forename: Hamid Reza
authors.initials: HR
authors.lastname: KhorramKhorshid
authors.affiliation: Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran.
authors.forename: Koorosh
authors.initials: K
authors.lastname: Kamali
authors.affiliation: Department of Pediatric, Dental School, Semnan University of Medical Sciences, Semnan, Iran.
authors.forename: Mehdi Salehi
authors.initials: MS
authors.lastname: Zeinabadi
keywords: Folic acid supplementation; methylenetetrahydrofolate reductase gene; orofacial clefts; polymorphism