title: Phomopsichin A-D; Four New Chromone Derivatives from Mangrove Endophytic Fungus Phomopsis sp. 33.
abstract: Four new chromone derivatives, phomopsichins A-D (1-4), along with a known compound, phomoxanthone A (5), were isolated from the fermentation products of mangrove endophytic fungusPhomopsissp. 33#. Their structures were elucidated based on comprehensive spectroscopic analysis coupled with single-crystal X-ray diffraction or theoretical calculations of electronic circular dichroism (ECD). They feature a tricyclic framework, in which a dihydropyran ring is fused with the chromone ring. Compounds1-5showed weak inhibitory activities on acetylcholinesterase as well as α-glucosidase, weak radical scavenging effects on 1,1-diphenyl-2-picrylhydrazyl (DPPH) as well as OH, and weak antimicrobial activities. Compounds1-4showed no cytotoxic activity against MDA-MB-435 breast cancer cells. Their other bioactivities are worthy of further study, considering their unique molecular structures.
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. huangmx7@mail2.sysu.edu.cn.
authors.forename: Meixiang
authors.initials: M
authors.lastname: Huang
authors.affiliation: School of Marine Sciences, Sun Yat-sen University, Guangzhou 510006, China. lijing356@mail.sysu.edu.cn.|Key Laboratory of Functional Molecules from Oceanic Microorganisms (Sun Yat-sen University), Department of Education of Guangdong Province, Guangzhou 510080, China. lijing356@mail.sysu.edu.cn.
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.affiliation: School of Marine Sciences, Sun Yat-sen University, Guangzhou 510006, China. cesllan@mail.sysu.edu.cn.|South China Sea Bio-Resource Exploitation and Utilization Collaborative Innovation Center, Guangzhou 510006, China. cesllan@mail.sysu.edu.cn.
authors.forename: Lan
authors.initials: L
authors.lastname: Liu
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. yinsh2@mail.sysu.edu.cn.
authors.forename: Sheng
authors.initials: S
authors.lastname: Yin
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. wjun@mail.sysu.edu.cn.
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.affiliation: Key Laboratory of Functional Molecules from Oceanic Microorganisms (Sun Yat-sen University), Department of Education of Guangdong Province, Guangzhou 510080, China. ceslyc@mail.sysu.edu.cn.|South China Sea Bio-Resource Exploitation and Utilization Collaborative Innovation Center, Guangzhou 510006, China. ceslyc@mail.sysu.edu.cn.|School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China. ceslyc@mail.sysu.edu.cn.
authors.forename: Yongcheng
authors.initials: Y
authors.lastname: Lin
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D001713:Biphenyl Compounds / Q000378:metabolism; D001943:Breast Neoplasms / Q000188:drug therapy; D045744:Cell Line, Tumor; D002867:Chromones / Q000737:chemistry* / Q000494:pharmacology; D018360:Crystallography, X-Ray / Q000379:methods; D060026:Endophytes / Q000737:chemistry*; D005285:Fermentation / Q000502:physiology; D005658:Fungi / Q000737:chemistry*; D006801:Humans; D015394:Molecular Structure; D010851:Picrates / Q000378:metabolism; D014961:X-Ray Diffraction / Q000379:methods; D044004:Xanthones / Q000737:chemistry / Q000494:pharmacology; D000520:alpha-Glucosidases / Q000378:metabolism
chemical_list: D001713:Biphenyl Compounds; D002867:Chromones; D010851:Picrates; D044004:Xanthones; C436332:phomoxanthone A; C004931:1,1-diphenyl-2-picrylhydrazyl; D000110:Acetylcholinesterase; D000520:alpha-Glucosidases
keywords: Phomopsis sp.; chromone derivatives; mangrove endophytic fungi; secondary metabolites