title: Cognitive Performance in Subjects With Multiple Sclerosis Is Robustly Influenced by Gender in Canonical-Correlation Analysis.
abstract: The authors explored the relations between clinical/demographic characteristics and performance on a neuropsychological battery (eight tests) in a cohort (N=46) of multiple sclerosis (MS) subjects. Findings resulted from a secondary analysis of a study examining the relationships between imaging biomarkers in MS and cognitive tasks of executive functioning. The objective was to determine whether the overlapping test results could be judiciously combined and associated with clinical/demographic variables. Canonical-correlation analysis (CCA) was utilized, and it was found that differences between performance on untimed tests, and the sum of performance on timed Trail-Making Tests, Parts A and B, best matched clinical/demographic variables, and gender was the most important feature.
authors.affiliation: From the Graduate Program in Neuroscience, University of British Columbia (S-JL, MM); the Department of Statistics, University of British Columbia (JL); the Graduate Program in Counselling Psychology, University of British Columbia (SB); the Department of Radiology, University of British Columbia (IV, AM); the Department of Neurology, Faculty of Medicine, University of British Columbia (AT, DL, MM); the Department of Physics and Astronomy, University of British Columbia (AM); and the Department of Psychiatry, University of British Columbia Hospital (BK).
authors.forename: Sue-Jin
authors.initials: SJ
authors.lastname: Lin
authors.affiliation: From the Graduate Program in Neuroscience, University of British Columbia (S-JL, MM); the Department of Statistics, University of British Columbia (JL); the Graduate Program in Counselling Psychology, University of British Columbia (SB); the Department of Radiology, University of British Columbia (IV, AM); the Department of Neurology, Faculty of Medicine, University of British Columbia (AT, DL, MM); the Department of Physics and Astronomy, University of British Columbia (AM); and the Department of Psychiatry, University of British Columbia Hospital (BK).
authors.forename: Janet
authors.initials: J
authors.lastname: Lam
authors.affiliation: From the Graduate Program in Neuroscience, University of British Columbia (S-JL, MM); the Department of Statistics, University of British Columbia (JL); the Graduate Program in Counselling Psychology, University of British Columbia (SB); the Department of Radiology, University of British Columbia (IV, AM); the Department of Neurology, Faculty of Medicine, University of British Columbia (AT, DL, MM); the Department of Physics and Astronomy, University of British Columbia (AM); and the Department of Psychiatry, University of British Columbia Hospital (BK).
authors.forename: Samantha
authors.initials: S
authors.lastname: Beveridge
authors.affiliation: From the Graduate Program in Neuroscience, University of British Columbia (S-JL, MM); the Department of Statistics, University of British Columbia (JL); the Graduate Program in Counselling Psychology, University of British Columbia (SB); the Department of Radiology, University of British Columbia (IV, AM); the Department of Neurology, Faculty of Medicine, University of British Columbia (AT, DL, MM); the Department of Physics and Astronomy, University of British Columbia (AM); and the Department of Psychiatry, University of British Columbia Hospital (BK).
authors.forename: Irene
authors.initials: I
authors.lastname: Vavasour
authors.affiliation: From the Graduate Program in Neuroscience, University of British Columbia (S-JL, MM); the Department of Statistics, University of British Columbia (JL); the Graduate Program in Counselling Psychology, University of British Columbia (SB); the Department of Radiology, University of British Columbia (IV, AM); the Department of Neurology, Faculty of Medicine, University of British Columbia (AT, DL, MM); the Department of Physics and Astronomy, University of British Columbia (AM); and the Department of Psychiatry, University of British Columbia Hospital (BK).
authors.forename: Anthony
authors.initials: A
authors.lastname: Traboulsee
authors.affiliation: From the Graduate Program in Neuroscience, University of British Columbia (S-JL, MM); the Department of Statistics, University of British Columbia (JL); the Graduate Program in Counselling Psychology, University of British Columbia (SB); the Department of Radiology, University of British Columbia (IV, AM); the Department of Neurology, Faculty of Medicine, University of British Columbia (AT, DL, MM); the Department of Physics and Astronomy, University of British Columbia (AM); and the Department of Psychiatry, University of British Columbia Hospital (BK).
authors.forename: David K B
authors.initials: DKB
authors.lastname: Li
authors.affiliation: From the Graduate Program in Neuroscience, University of British Columbia (S-JL, MM); the Department of Statistics, University of British Columbia (JL); the Graduate Program in Counselling Psychology, University of British Columbia (SB); the Department of Radiology, University of British Columbia (IV, AM); the Department of Neurology, Faculty of Medicine, University of British Columbia (AT, DL, MM); the Department of Physics and Astronomy, University of British Columbia (AM); and the Department of Psychiatry, University of British Columbia Hospital (BK).
authors.forename: Alex
authors.initials: A
authors.lastname: MacKay
authors.affiliation: From the Graduate Program in Neuroscience, University of British Columbia (S-JL, MM); the Department of Statistics, University of British Columbia (JL); the Graduate Program in Counselling Psychology, University of British Columbia (SB); the Department of Radiology, University of British Columbia (IV, AM); the Department of Neurology, Faculty of Medicine, University of British Columbia (AT, DL, MM); the Department of Physics and Astronomy, University of British Columbia (AM); and the Department of Psychiatry, University of British Columbia Hospital (BK).
authors.forename: Martin
authors.initials: M
authors.lastname: McKeown
authors.affiliation: From the Graduate Program in Neuroscience, University of British Columbia (S-JL, MM); the Department of Statistics, University of British Columbia (JL); the Graduate Program in Counselling Psychology, University of British Columbia (SB); the Department of Radiology, University of British Columbia (IV, AM); the Department of Neurology, Faculty of Medicine, University of British Columbia (AT, DL, MM); the Department of Physics and Astronomy, University of British Columbia (AM); and the Department of Psychiatry, University of British Columbia Hospital (BK).
authors.forename: Brenda
authors.initials: B
authors.lastname: Kosaka
mesh_terms: D000328:Adult; D003072:Cognition Disorders / Q000000981:diagnostic imaging / Q000209:etiology*; D015331:Cohort Studies; D056344:Executive Function / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications* / Q000000981:diagnostic imaging; D009483:Neuropsychological Tests; D012727:Sex Characteristics; D013223:Statistics as Topic / Q000379:methods*; D055815:Young Adult
keywords: Multiple Sclerosis; Neuropsychology