title: Damxungmacin A and B, Two New Amicoumacins with Rare Heterocyclic Cores Isolated from Bacillus subtilis XZ-7.
abstract: Two new amicoumacins, named Damxungmacin A (1) and B (2), were isolated from the culture broth of a soil-derived bacteriumBacillus subtilisXZ-7. Their chemical structures were elucidated by spectroscopic studies (UV, IR, NMR and HR-ESI-MS). Compound1possessed a 1,4-diazabicyclo[2.2.1]heptane-2-one ring system in its structure, which was reported for the first time, while2had a 1-acetylmorpholine-3-one moiety, which was naturally rare. Compound1exhibited moderate to weak cytotoxic activities against three human tumor cell lines (A549, HCT116 and HepG2) with IC50values of 13.33, 14.34 and 13.64 μM, respectively. Meanwhile, compound1showed weak antibacterial activities against some strains ofStaphylococcus epidermidis, while compound2at 16 μg/mL did not show antibacterial activity.
authors.affiliation: School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, Jiangsu, China. tanghuilingyaya@126.com.|School of Pharmacy, Jiangsu Food & Pharmaceutical Science College, Huaian 223005, Jiangsu, China. tanghuilingyaya@126.com.
authors.forename: Hui-Ling
authors.initials: HL
authors.lastname: Tang
authors.affiliation: Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. chenghangsun@hotmail.com.
authors.forename: Cheng-Hang
authors.initials: CH
authors.lastname: Sun
authors.affiliation: Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. huxinxin1985@163.com.
authors.forename: Xin-Xin
authors.initials: XX
authors.lastname: Hu
authors.affiliation: Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. xuefuyou@hotmail.com.
authors.forename: Xue-Fu
authors.initials: XF
authors.lastname: You
authors.affiliation: School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, Jiangsu, China. minwang@cpu.edu.cn.
authors.forename: Min
authors.initials: M
authors.lastname: Wang
authors.affiliation: Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. liushaowei3535@163.com.
authors.forename: Shao-Wei
authors.initials: SW
authors.lastname: Liu
mesh_terms: D000072283:A549 Cells; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000737:chemistry* / Q000302:isolation & purification; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D045325:HCT116 Cells; D056945:Hep G2 Cells; D006801:Humans; D015394:Molecular Structure; D012988:Soil Microbiology; D013212:Staphylococcus epidermidis / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D003374:Coumarins
keywords: Bacillus subtilis; Damxungmacin; amicoumacins; antibacterial activity; cytotoxic activity