title: Genetic predisposition in gynecologic cancers.
abstract: This review article discusses the diagnosis and management of hereditary ovarian cancer and hereditary uterine cancer. The key recommendations highlighted are: All women with high grade non-mucinous epithelial ovarian cancer should be offered at least BRCA1 and BRCA2 genetic testing. The care of women with BRCA-associated ovarian cancer should be tailored to their mutation status. Risk-reducing bilateral salpingo-oophorectomy is recommended for women with BRCA1/2 mutations. Women with endometrial cancer should be assessed for the possibility of Lynch syndrome. Individuals with Lynch syndrome should undergo screening colonoscopy every 1-2 years. Lynch syndrome causes a high risk of endometrial cancer, and women with Lynch syndrome should consult with a gynecologic specialist to formulate a plan for managing this risk.
authors.affiliation: Department of Gynecologic Oncology and Reproductive Medicine, MD Anderson Cancer Center, Houston, TX.
authors.forename: Molly S
authors.initials: MS
authors.lastname: Daniels
authors.affiliation: Department of Gynecologic Oncology and Reproductive Medicine, MD Anderson Cancer Center, Houston, TX. Electronic address: khlu@mdanderson.org.
authors.forename: Karen H
authors.initials: KH
authors.lastname: Lu
mesh_terms: D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000235:genetics; D005260:Female; D019398:Genes, BRCA1; D024522:Genes, BRCA2; D020022:Genetic Predisposition to Disease; D005833:Genital Neoplasms, Female / Q000175:diagnosis / Q000235:genetics*; D006801:Humans; D009154:Mutation
keywords: BRCA1/2; Endometrial cancer; Hereditary cancer; Lynch syndrome; Ovarian cancer