title: B Cell Lymphoma-2-Modified Bone Marrow-Derived Mesenchymal Stem Cells Transplantation for the Treatment of Diabetes Mellitus-Induced Erectile Dysfunction in a Rat Model.
abstract: OBJECTIVE
  The study aimed to explore the effects of B cell lymphoma-2 (Bcl-2)-modified bone marrow-derived mesenchymal stem cells (BMSCs) transplantation for the treatment of diabetes mellitus-induced erectile dysfunction (DMED) in a rat model.
  
  
  METHODS
  The DMED rat model was successfully established. Thirty-six DMED rats were assigned into the Bcl-2-BMSCs, null-BMSCs, BMSCs and phosphate buffered saline (PBS) groups. Meanwhile, 9 normal rats injected with PBS were taken as the normal control group.
  
  
  RESULTS
  In the Bcl-2-BMSCs group, the average times of erection, rate of erection, peak intra-cavernous pressure (ICP) and peak ICP/mean arterial pressure were higher than those in the null-BMSCs, BMSCs and PBS groups, but were lower than those in the normal control group. In the Bcl-2-BMSCs group, capillary vessels and Bcl-2 mRNA and protein expressions were similar to those in the normal control group, while they were higher than those in other groups.
  
  
  CONCLUSIONS
  These findings indicate that Bcl-2-modified BMSC transplantation could improve erectile function in DMED rats.
authors.affiliation: Department of Urology, The First Affiliated Hospital of Nanchang University, Nanchang, PR China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Sun
authors.forename: Long-Hua
authors.initials: LH
authors.lastname: Luo
authors.forename: Liang
authors.initials: L
authors.lastname: Feng
authors.forename: Dong-Shui
authors.initials: DS
authors.lastname: Li
authors.forename: Ke-Zhao
authors.initials: KZ
authors.lastname: Zhong
mesh_terms: D000818:Animals; D001794:Blood Pressure; D001854:Bone Marrow Cells / Q000166:cytology; D048909:Diabetes Complications / Q000150:complications* / Q000628:therapy*; D003920:Diabetes Mellitus; D004195:Disease Models, Animal; D007172:Erectile Dysfunction / Q000150:complications* / Q000628:therapy*; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000166:cytology; D010410:Penile Erection; D010413:Penis / Q000378:metabolism; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D019253:Proto-Oncogene Proteins c-bcl-2; D012333:RNA, Messenger