title: Comparison of 7T and 3T MRI in patients with moyamoya disease.
abstract: Magnetic resonance imaging and magnetic resonance angiography (MRI/MRA) are widely used for evaluating the moyamoya disease (MMD). This study compared the diagnostic accuracy of 7Tesla (T) and 3T MRI/MRA in MMD. In this case control study, 12 patients [median age: 34years; range (10-66years)] with MMD and 12 healthy controls [median age: 25years; range (22-59years)] underwent both 7T and 3T MRI/MRA. To evaluate the accuracy of MRI/MRA in MMD, five criteria were compared between imaging systems of 7T and 3T: Suzuki grading system, internal carotid artery (ICA) diameter, ivy sign, flow void of the basal ganglia on T2-weighted images, and high signal intensity areas of the basal ganglia on time-of-flight (TOF) source images. No difference was observed between 7T and 3T MRI/MRA in Suzuki stage, ICA diameter, and ivy sign score; while, 7T MRI/MRA showed a higher detection rate in the flow void on T2-weighted images and TOF source images (p<0.001). Receiver operating characteristic curves of both T2 and TOF criteria showed that 7T MRI/MRA had higher sensitivity and specificity than 3T MRI/MRA. Our findings indicate that 7T MRI/MRA is superior to 3T MRI/MRA for the diagnosis of MMD in point of detecting the flow void in basal ganglia by T2-weighted and TOF images.
authors.affiliation: Department of Neurosurgery, Chungbuk National University Hospital, Chungbuk National University, College of Medicine, Cheongju, Republic of Korea.
authors.forename: Byeong Ho
authors.initials: BH
authors.lastname: Oh
authors.affiliation: Department of Medical Neuroscience, Chungbuk National University Hospital, Chungbuk National University, College of Medicine, Cheongju, Republic of Korea.
authors.forename: Hyeong Cheol
authors.initials: HC
authors.lastname: Moon
authors.affiliation: Bioimaging Research Team, Korea Basic Science Institute, Cheongju, Republic of Korea.
authors.forename: Hyeon Man
authors.initials: HM
authors.lastname: Baek
authors.affiliation: Department or Radiology, The Catholic University of Korea, Daejeon St. Mary's Hospital, Republic of Korea.
authors.forename: Youn Joo
authors.initials: YJ
authors.lastname: Lee
authors.affiliation: Bioimaging Research Team, Korea Basic Science Institute, Cheongju, Republic of Korea.
authors.forename: Sang Woo
authors.initials: SW
authors.lastname: Kim
authors.affiliation: Bioimaging Research Team, Korea Basic Science Institute, Cheongju, Republic of Korea.
authors.forename: Young Jai
authors.initials: YJ
authors.lastname: Jeon
authors.affiliation: Department of Neurosurgery, Chungbuk National University Hospital, Chungbuk National University, College of Medicine, Cheongju, Republic of Korea.
authors.forename: Gun Seok
authors.initials: GS
authors.lastname: Lee
authors.affiliation: Department of Neurosurgery, Chungbuk National University Hospital, Chungbuk National University, College of Medicine, Cheongju, Republic of Korea.
authors.forename: Hong Rae
authors.initials: HR
authors.lastname: Kim
authors.affiliation: Department of Neurosurgery, Chungbuk National University Hospital, Chungbuk National University, College of Medicine, Cheongju, Republic of Korea.
authors.forename: Jai Ho
authors.initials: JH
authors.lastname: Choi
authors.affiliation: Department of Neurosurgery, Chungbuk National University Hospital, Chungbuk National University, College of Medicine, Cheongju, Republic of Korea.
authors.forename: Kyung Soo
authors.initials: KS
authors.lastname: Min
authors.affiliation: Department of Neurosurgery, Chungbuk National University Hospital, Chungbuk National University, College of Medicine, Cheongju, Republic of Korea.
authors.forename: Mou Seop
authors.initials: MS
authors.lastname: Lee
authors.affiliation: Department of Neurosurgery, Chungbuk National University Hospital, Chungbuk National University, College of Medicine, Cheongju, Republic of Korea.
authors.forename: Young Gyu
authors.initials: YG
authors.lastname: Kim
authors.affiliation: Department of Neurosurgery, Chungbuk National University Hospital, Chungbuk National University, College of Medicine, Cheongju, Republic of Korea.
authors.forename: Dong Ho
authors.initials: DH
authors.lastname: Kim
authors.affiliation: Department of Pediatrics, Chungbuk National University, College of Medicine, Cheongju, Republic of Korea.
authors.forename: Won Seop
authors.initials: WS
authors.lastname: Kim
authors.affiliation: Department of Neurosurgery, Chungbuk National University Hospital, Chungbuk National University, College of Medicine, Cheongju, Republic of Korea; Department of Medical Neuroscience, Chungbuk National University Hospital, Chungbuk National University, College of Medicine, Cheongju, Republic of Korea. Electronic address: youngseokparkmd@gmail.com.
authors.forename: Young Seok
authors.initials: YS
authors.lastname: Park
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002339:Carotid Arteries / Q000000981:diagnostic imaging; D002648:Child; D005260:Female; D006801:Humans; D018810:Magnetic Resonance Angiography / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009072:Moyamoya Disease / Q000000981:diagnostic imaging*; D012372:ROC Curve; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D055815:Young Adult
keywords: 7T; Magnetic resonance angiography; Magnetic resonance image; Moyamoya disease