title: Afatinib-Induced Acute Fatal Pneumonitis in Metastatic Lung Adenocarcinoma.
abstract: Afatinib is an oral tyrosine kinase inhibitor (TKI) that inhibit Endothelial Growth Factor Receptor (EGFR), Human Epidermal Growth Factor Receptor 2 (HER2), and HER4. The common side effects of EGFR TKI are rash, acne, diarrhea, stomatitis, pruritus, nausea, and loss of appetite. Drug induced pneumonitis is the less common adverse effects of EGFR TKI. Afatinib, 2nd generation EGFR TKI is anticipated to overcome drug resistance from 1st generation EGFR TKI according to preclinical study, and several studies are being conducted to compare clinical efficacy between 1st and 2nd EGFR TKI. Several cases of rug induced acute fatal pneumonitis were reported after use of erlotinib or gefitinib. However, a case of acute fatal pneumonitis associated with afatinib was note reported except drug induced pneumonitis in other clinical study. Here, we present a cases of acute severe pneumonitis related with afatinib in metastatic lung adenocarcinoma with literature review.
authors.affiliation: Department of Internal Medicine, Daejeon St. Mary's Hospital, The Catholic University of Korea College of Medicine, Daejeon, Korea.
authors.forename: Sang Hoon
authors.initials: SH
authors.lastname: Yoo
authors.affiliation: Department of Internal Medicine, Daejeon St. Mary's Hospital, The Catholic University of Korea College of Medicine, Daejeon, Korea.
authors.forename: Jin Ah
authors.initials: JA
authors.lastname: Ryu
authors.affiliation: Department of Internal Medicine, Daejeon St. Mary's Hospital, The Catholic University of Korea College of Medicine, Daejeon, Korea.
authors.forename: Seo Ree
authors.initials: SR
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Daejeon St. Mary's Hospital, The Catholic University of Korea College of Medicine, Daejeon, Korea.
authors.forename: Su Yun
authors.initials: SY
authors.lastname: Oh
authors.affiliation: Department of Internal Medicine, Daejeon St. Mary's Hospital, The Catholic University of Korea College of Medicine, Daejeon, Korea.
authors.forename: Gu Sung
authors.initials: GS
authors.lastname: Jung
authors.affiliation: Department of Internal Medicine, Daejeon St. Mary's Hospital, The Catholic University of Korea College of Medicine, Daejeon, Korea.
authors.forename: Dong Jae
authors.initials: DJ
authors.lastname: Lee
authors.affiliation: Department of Internal Medicine, Daejeon St. Mary's Hospital, The Catholic University of Korea College of Medicine, Daejeon, Korea.
authors.forename: Bong Gyu
authors.initials: BG
authors.lastname: Kwak
authors.affiliation: Department of Internal Medicine, Daejeon St. Mary's Hospital, The Catholic University of Korea College of Medicine, Daejeon, Korea.
authors.forename: Yu Hyun
authors.initials: YH
authors.lastname: Nam
authors.affiliation: Department of Internal Medicine, Daejeon St. Mary's Hospital, The Catholic University of Korea College of Medicine, Daejeon, Korea.
authors.forename: Kyung Hyun
authors.initials: KH
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Daejeon St. Mary's Hospital, The Catholic University of Korea College of Medicine, Daejeon, Korea.
authors.forename: Young Jun
authors.initials: YJ
authors.lastname: Yang
keywords: Acute Fatal Pneumonitis; Afatinib; Metastatic Lung Adenocarcinoma