title: Comparison of psychodrug prescription patterns in patients diagnosed with bipolar disorder and addiction.
abstract: OBJECTIVE
  To describe if there are differences in the prescription of psychodrug at discharge between bipolar disorder patients with or without addiction.
  
  
  METHODS
  We review all the psychotropic drugs dispensed to inpatients of a brief hospitalization psychiatric unit diagnosed as having bipolar disorder at time of discharge. We recluted 225 patients over 18 years old on their last manic episode, between the year 2000 and 2010. We classify them according to the comorbid presence or not of a substance abuse or dependence disorder.
  
  
  RESULTS
  Prevalence of addiction was 24%. We found no differences between groups in the number of psychotropic drugs prescribed at discharge. The prescription pattern of mood stabilizers and benzodiazepines was similar in both groups. We detect differences in the total daily dose of antipsychotic, expressed as risperidone equivalents (5.86 ± 4.62 mg in addictions group versus 4.67 ± 3.20 mg in control group, p=0.042) and in the total daily dose of biperideno (4.80 ± 1.78 mg in addictions group versus 3.20 ± 1.03 mg in the control group, p=0.044).
  
  
  CONCLUSIONS
  Contrary to our expectations, both groups were similar in psychopharmacological prescription patterns at discharge. However, those patients with substance abuse disorder had higher doses of antipsychotics and higher dose biperiden at discharge.
authors.affiliation: Psiquiatra y Estudiante Pre-doctoral. Departamento de Farmacología de la Universidad Autónoma de Barcelona. España.
authors.forename: Diego
authors.initials: D
authors.lastname: Barral
authors.affiliation: Enfermera. Complejo Hospitalario Universitario de Santiago. España.
authors.forename: Fátima
authors.initials: F
authors.lastname: Barral
authors.affiliation: Farmacóloga Clínica, Doctora en Neurociencia. Universidad de Barcelona. España.
authors.forename: Nuria
authors.initials: N
authors.lastname: Cruz
authors.affiliation: Psiquiatra. Doctor. Hospital Doctor Rodríguez Lafora. Madrid. España.
authors.forename: Juan D
authors.initials: JD
authors.lastname: Molina
authors.affiliation: Psicóloga Clínica. Grupo Laberinto. Madrid. España.
authors.forename: Victoria
authors.initials: V
authors.lastname: Sánchez
authors.affiliation: Psicóloga Clínica. Hospital Doctor Rodríguez Lafora. Madrid. España.
authors.forename: Teresa
authors.initials: T
authors.lastname: Rosique
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001714:Bipolar Disorder / Q000150:complications* / Q000188:drug therapy*; D011307:Drug Prescriptions / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010351:Patient Discharge; D011619:Psychotropic Drugs / Q000627:therapeutic use*; D019966:Substance-Related Disorders / Q000150:complications*
chemical_list: D014150:Antipsychotic Agents; D011619:Psychotropic Drugs