title: Long-term visual and systemic prognoses of 83 cases of biopsy-proven sarcoid uveitis.
abstract: To determine the long-term visual and systemic outcomes of uveitis patients with biopsy-proven sarcoidosis.
  
  
  
  A retrospective study of biopsy-proven sarcoid uveitis, with a 3-year minimum follow-up, seen at Lyon University Hospital, between April 2004 and January 2016.
  
  
  
  A total of 83 patients were included, with a median age at onset of 52 (37-62) years and an unbalanced gender ratio (women 77.1%). Thirty-one patients had original systemic sarcoidosis in addition to ocular localisation, whereas 52 initially presented with isolated sarcoid uveitis. Among the latter, 7.7% (n=4) developed an extraocular disease after a median follow-up duration of 60 (44-110) months. The systemic spread in these patients included cutaneous sarcoids (n=2), arthritis (n=1) and multiple mononeuritis (n=1). Complete visual recovery was obtained for 60.2% of all patients and 89.2% had retrieved best-corrected visual acuity (BCVA) >20/50 in both eyes. A unilateral loss of BCVA of worse than 20/200 was documented in two patients in the isolated sarcoid uveitis group. No patient suffered from bilateral severe visual impairment or blindness. Factors linked to a poor visual prognosis, defined by BCVA ≤20/50 in at least one eye, were chronic macular oedema (p=0.009) and persistent ocular inflammation (p=0.0005).
  
  
  
  In this large European series of biopsy-proven sarcoidosis to date, with a prolonged follow-up, sarcoid uveitis was suggestive of a favourable systemic and visual outcome. Clinically isolated uveitis that revealed sarcoidosis remained a strictly ocular condition in most cases.
authors.affiliation: Department of Ophthalmology, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France.|University Claude Bernard-Lyon 1, Villeurbanne, France.
authors.forename: Cédric
authors.initials: C
authors.lastname: Rochepeau
authors.affiliation: University Claude Bernard-Lyon 1, Villeurbanne, France.|Department of Internal Medicine, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France.
authors.forename: Yvan
authors.initials: Y
authors.lastname: Jamilloux
authors.affiliation: Department of Anesthesiology and Critical Care, St Louis-Lariboisière University Hospital, AP-HP, University Denis Diderot-Paris VII, Paris, France.|ECSTRA Team, Epidemiology and Biostatistics Sorbonne Paris Cité Research Centre UMR 1153, Inserm, Paris, France.|University of Paris VII Denis Diderot, Paris, France.
authors.forename: Sebastien
authors.initials: S
authors.lastname: Kerever
authors.affiliation: Department of Ophthalmology, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France.|University Claude Bernard-Lyon 1, Villeurbanne, France.
authors.forename: Camille
authors.initials: C
authors.lastname: Febvay
authors.affiliation: University Claude Bernard-Lyon 1, Villeurbanne, France.|Department of Internal Medicine, Hôpital Edouard Herriot, Hospices Civils de Lyon, Lyon, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Perard
authors.affiliation: University Claude Bernard-Lyon 1, Villeurbanne, France.|Department of Internal Medicine, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France.
authors.forename: Christiane
authors.initials: C
authors.lastname: Broussolle
authors.affiliation: University Claude Bernard-Lyon 1, Villeurbanne, France.|Department of Ophthalmology, Hôpital Edouard Herriot, Hospices Civils de Lyon, Lyon, France.
authors.forename: Carole
authors.initials: C
authors.lastname: Burillon
authors.affiliation: Department of Ophthalmology, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France.|University Claude Bernard-Lyon 1, Villeurbanne, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Kodjikian
authors.affiliation: University Claude Bernard-Lyon 1, Villeurbanne, France.|Department of Internal Medicine, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France.
authors.forename: Pascal
authors.initials: P
authors.lastname: Seve
mesh_terms: D000328:Adult; D000869:Anterior Eye Segment / Q000473:pathology*; D001706:Biopsy / Q000379:methods*; D018450:Disease Progression; D005260:Female; D005451:Fluorescein Angiography / Q000379:methods; D005500:Follow-Up Studies; D005654:Fundus Oculi; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D012507:Sarcoidosis / Q000175:diagnosis* / Q000503:physiopathology; D013997:Time Factors; D041623:Tomography, Optical Coherence / Q000379:methods; D014057:Tomography, X-Ray Computed; D014605:Uveitis / Q000175:diagnosis* / Q000503:physiopathology; D014792:Visual Acuity
keywords: Epidemiology; Inflammation