title: Effect of oxygen therapy on myocardial salvage in ST elevation myocardial infarction: the randomized SOCCER trial.
abstract: OBJECTIVE
  Recent studies suggest that administration of O2 in patients with acute myocardial infarction may have negative effects. With the use of cardiac MRI (CMR), we evaluated the effects of supplemental O2 in patients with ST elevation myocardial infarction (STEMI) accepted for acute percutaneous coronary intervention (PCI).
  
  
  METHODS
  This study was a randomized-controlled trial conducted at two university hospitals in Sweden. Normoxic STEMI patients were randomized in the ambulance to either supplemental O2 (10 l/min) or room air until the conclusion of the PCI. CMR was performed 2-6 days after the inclusion. The primary endpoint was the myocardial salvage index assessed by CMR. The secondary endpoints included infarct size and myocardium at risk.
  
  
  RESULTS
  At inclusion, the O2 (n=46) and air (n=49) patient groups had similar patient characteristics. There were no significant differences in myocardial salvage index [53.9±25.1 vs. 49.3±24.0%; 95% confidence interval (CI): -5.4 to 14.6], myocardium at risk (31.9±10.0% of the left ventricle in the O2 group vs. 30.0±11.8% in the air group; 95% CI: -2.6 to 6.3), or infarct size (15.6±10.4% of the left ventricle vs. 16.0±11.0%; 95% CI: -4.7 to 4.1).
  
  
  CONCLUSIONS
  In STEMI patients undergoing acute PCI, we found no effect of high-flow oxygen compared with room air on the size of ischemia before PCI, myocardial salvage, or the resulting infarct size. These results support the safety of withholding supplemental oxygen in normoxic STEMI patients.
authors.affiliation: Department of Emergency and Internal Medicine.
authors.forename: Ardavan
authors.initials: A
authors.lastname: Khoshnood
authors.affiliation: Section of Clinical Physiology, Clinical Sciences Lund, Skåne University Hospital, Lund University.
authors.forename: Marcus
authors.initials: M
authors.lastname: Carlsson
authors.affiliation: Department of Emergency and Internal Medicine.
authors.forename: Mahin
authors.initials: M
authors.lastname: Akbarzadeh
authors.affiliation: Department of Cardiology, Skåne University Hospital, Malmö, Sweden.
authors.forename: Pallonji
authors.initials: P
authors.lastname: Bhiladvala
authors.affiliation: Department of Cardiology, Skåne University Hospital.
authors.forename: Anders
authors.initials: A
authors.lastname: Roijer
authors.affiliation: Section of Clinical Physiology, Clinical Sciences Lund, Skåne University Hospital, Lund University.
authors.forename: David
authors.initials: D
authors.lastname: Nordlund
authors.affiliation: Region Skåne Research and Development Centre.
authors.forename: Peter
authors.initials: P
authors.lastname: Höglund
authors.affiliation: Department of Cardiology, Skåne University Hospital.
authors.forename: David
authors.initials: D
authors.lastname: Zughaft
authors.affiliation: Region Skåne Prehospital Unit, Lund.
authors.forename: Lizbet
authors.initials: L
authors.lastname: Todorova
authors.affiliation: Department of Emergency and Internal Medicine.
authors.forename: Arash
authors.initials: A
authors.lastname: Mokhtari
authors.affiliation: Section of Clinical Physiology, Clinical Sciences Lund, Skåne University Hospital, Lund University.
authors.forename: Håkan
authors.initials: H
authors.lastname: Arheden
authors.affiliation: Department of Cardiology, Skåne University Hospital.
authors.forename: David
authors.initials: D
authors.lastname: Erlinge
authors.affiliation: Department of Emergency and Internal Medicine.
authors.forename: Ulf
authors.initials: U
authors.lastname: Ekelund
mesh_terms: D000328:Adult; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010102:Oxygen Inhalation Therapy / Q000379:methods*; D062645:Percutaneous Coronary Intervention / Q000379:methods; D000072657:ST Elevation Myocardial Infarction / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000628:therapy*; D016896:Treatment Outcome