title: Diabetes Onset at 31-45 Years of Age is Associated with an Increased Risk of Diabetic Retinopathy in Type 2 Diabetes.
abstract: This hospital-based, cross-sectional study investigated the effect of age of diabetes onset on the development of diabetic retinopathy (DR) among Chinese type 2 diabetes mellitus (DM) patients. A total of 5,214 patients with type 2 DM who were referred to the Department of Ophthalmology at the Shanghai First People's Hospital from 2009 to 2013 was eligible for inclusion. Diabetic retinopathy status was classified using the grading system of the Early Treatment Diabetic Retinopathy Study (ETDRS). Logistic and hierarchical regression analyses were used to identify independent variables affecting the development of DR. Upon multiple logistic regression analysis, patient age at the time of diabetes onset was significantly associated with development of DR. Further, when the risk of retinopathy was stratified by patient age at the onset of diabetes, the risk was highest in patients in whom diabetes developed at an age of 31-45 years (odds ratio [OR] 1.815 [1.139-2.892]; p = 0.012). Furthermore, when patients were divided into four groups based on the duration of diabetes, DR development was maximal at a diabetes onset age of 31-45 years within each group. A diabetes onset age of 31-45 years is an independent risk factor for DR development in Chinese type 2 DM patients.
authors.affiliation: Department of Ophthalmology, Shanghai First People's Hospital of Nanjing Medical University, Shanghai 200080, China.|Department of Ophthalmology, Nanjing Medical University Affiliated Wuxi Second Hospital, Wuxi 214002, China.
authors.forename: Wenjun
authors.initials: W
authors.lastname: Zou
authors.affiliation: Department of Ophthalmology, Shanghai First People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China.|Department of Ophthalmology, Lishui People's Hospital, Lishui 323000, China.
authors.forename: Lisha
authors.initials: L
authors.lastname: Ni
authors.affiliation: Department of Ophthalmology, Shanghai First People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China.|Department of Ophthalmology, the First Affiliated Hospital of Soochow University, Suzhou 215006, China.
authors.forename: Qianyi
authors.initials: Q
authors.lastname: Lu
authors.affiliation: Department of Ophthalmology, Shanghai First People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Zou
authors.affiliation: Department of Ophthalmology, Shanghai First People's Hospital of Nanjing Medical University, Shanghai 200080, China.
authors.forename: Minjie
authors.initials: M
authors.lastname: Zhao
authors.affiliation: Department of Ophthalmology, Shanghai First People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China.
authors.forename: Xun
authors.initials: X
authors.lastname: Xu
authors.affiliation: Department of Endocrinology and Metabolism, the Sixth People's Hospital of Shanghai, Shanghai Jiao Tong University, Shanghai 200233, China.
authors.forename: Haibing
authors.initials: H
authors.lastname: Chen
authors.affiliation: Department of Ophthalmology, Shanghai First People's Hospital of Nanjing Medical University, Shanghai 200080, China.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Zheng
mesh_terms: D000367:Age Factors; D044466:Asian People; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D003930:Diabetic Retinopathy / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors