title: Effectiveness and safety of pemetrexed for non-small cell lung cancer in the Andalusian Public Health System.
abstract: OBJECTIVE
  To evaluate effectiveness and safety profile of pemetrexed in patients with locally advanced or metastatic non-small-cell lung cancer (NSCLC) when it´s used on real clinical practice in Andalusia (a Spanish region with 8.5 million inhabitants, 2014 census data).
  
  
  METHODS
  An observational multicentre retrospective study was conducted. Adult patients with locally advanced/metastatic NSCLC who received pemetrexed in any hospital in the Andalusian Public Health System during the last term of 2011 were included. We collected patients´ baseline characteristics, diagnostic and treatment data, effectiveness variables (response to treatment with pemetrexed and overallsurvival) and main adverse reactions detected.
  
  
  RESULTS
  172 patients from 17 hospitals were included (77.33% were men), median age 63 years old (between 34 and 83). The predominant histology was adenocarcinoma (84.30%) and 85.20% were diagnosed of lung cancer with IV-stage. 78.49% had been smokers at some point in their lives. Median overall survival from the start of pemetrexed was 9 months (95%CI, 4.1-13.9). Progression of the disease was the most frequent response (33.14%), only one patient had complete response. Stable disease was associated with a higher probability of survival. Main adverse reactions detected were asthenia, haematological reactions, gastrointestinal reactions and dermal o mucous toxicity. No patients discontinued treatment for serious toxicity.
  
  
  CONCLUSIONS
  Pemetrexed resulted quite effective in NSCLC when it was used on real clinical practice, with higher survival in non-squamous histology and patients with the best score of Eastern Cooperative Oncology Group scale. The toxicity profile was well tolerated. Prospective studies would be needed to confirm the effect of prognostic factors observed.
authors.affiliation: Hospital Pharmacist. Pharmacy Department Hospital Universitario Virgen del Rocío, Seville.. sg.pm.mary@gmail.com.
authors.forename: María Antonia
authors.initials: MA
authors.lastname: Pérez-Moreno
authors.affiliation: Hospital Pharmacist. Pharmacy Department Hospital Universitario Virgen del Rocío, Seville.. jesus.cotrina.luque@gmail.com.
authors.forename: Jesús
authors.initials: J
authors.lastname: Cotrina-Luque
authors.affiliation: Hospital Pharmacist. Pharmacy Department Hospital Universitario Virgen del Rocío, Seville.. mercedes.galvan.sspa@juntadeandalucia.es.
authors.forename: Mercedes
authors.initials: M
authors.lastname: Galván-Banqueri
authors.affiliation: Hospital Pharmacist. Pharmacy Department Hospital Universitario Virgen del Rocío, Seville.. sg.pm.mary@gmail.com.
authors.forename: Sandra
authors.initials: S
authors.lastname: Flores-Moreno
authors.affiliation: Hospital Pharmacist. Pharmacy Department Hospital Universitario Virgen del Rocío, Seville.. franciscoj.bautista.sspa@juntadeandalucia.es.
authors.forename: Francisco Javier
authors.initials: FJ
authors.lastname: Bautista-Paloma
authors.affiliation: Hospital Pharmacist. Pharmacy Department. Hospital Universitario Virgen de las Nieves, Granada. Spain.. mangel.calleja.sspa@juntadeandalucia.es.
authors.forename: Miguel Ángel
authors.initials: MÁ
authors.lastname: Calleja-Hernández
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use*; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D000068437:Pemetrexed / Q000627:therapeutic use*; D012189:Retrospective Studies; D013030:Spain; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D000964:Antimetabolites, Antineoplastic; D000068437:Pemetrexed