title: Effect of Administration of Nandrolone Decanoate upon Aldosterone Concentration and Serum Na+/K+ Levels in Albino Mice.
abstract: BACKGROUND
  This article is a study of adverse effects associated with the abuse of recreational drugs such as anabolic androgenic steroids. Nandrolone decanoate is one such drug often abused by athletes and bodybuilders seeking enhanced physical strength or appearance. The use of such steroids has increased dramatically over the years.
  
  
  OBJECTIVE
  The present study was conducted to investigate the impact of nandrolone decanoate when consumed at an abused dose, upon serum aldosterone concentration in albino mice. Sodium and potassium ion concentrations were also monitored with the same experimental dosage.
  
  
  METHODS
  0.1ml of 25 mg Nandrolone decanoate was administered to the animals twice a week for a period of 90 days. Blood samples for obtaining the serum from both normal and treated group of animals were collected at an interval of 15 days upto the 90th day.
  
  
  RESULTS
  The present investigation revealed a significant increase (p<0.01) in the serum aldosterone and sodium ion concentrations in the treated group of animals compared to that in the normal group. Potassium ion concentration in the treated group did not exhibit a significant alteration when compared with the untreated animals.
  
  
  CONCLUSIONS
  From the above observation, nandrolone decanoate abuse could be suggested as one of the causes of aldosterone and electrolyte imbalance in the body that could possibly be a serious risk factor for cardiovascular related disorders.
authors.affiliation: Department of Zoology, Faculty of Sciences, Gauhati University, Guwahati, Assam, India.
authors.forename: Parmita
authors.initials: P
authors.lastname: Chowdhury
authors.affiliation: Department of Zoology, Faculty of Sciences, Cotton College, Guwahati, Assam, India.
authors.forename: Rita
authors.initials: R
authors.lastname: Mahanta
mesh_terms: D000450:Aldosterone / Q000097:blood*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D007477:Ions / Q000097:blood*; D008297:Male; D051379:Mice; D009277:Nandrolone / Q000009:adverse effects / Q000031:analogs & derivatives*; D000077603:Nandrolone Decanoate; D011188:Potassium / Q000097:blood*; D012964:Sodium / Q000097:blood*
chemical_list: D007477:Ions; D000450:Aldosterone; D009277:Nandrolone; D012964:Sodium; D000077603:Nandrolone Decanoate; D011188:Potassium
keywords: Albino mice; aldosterone; anabolic androgenic steroid; drug abuse; nandrolone decanoate; potassium; sodium