title: Cardiac function during resuscitation from hemorrhagic shock with polymerized bovine hemoglobin-based oxygen therapeutic.
abstract: Hemorrhage impairs myocardial contractile function and decreases oxygen delivery. This study investigates how polymerized bovine hemoglobin (PolyHb) solutions affect cardiac function after resuscitation from hemorrhagic shock (HS). Hamsters were hemorrhaged and resuscitated with PolyHb at 8.5 g/dL and 11.5 g/dL. Left ventricle (LV) function was assessed during shock and resuscitation using a miniaturize conductance catheter. PolyHb resuscitation had no beneficial effects in cardiac function; it increased cardiac afterload and systemic vascular resistance (SVR) of 46 and 116% for 8.5 and 11.5 g/dL, respectively. Study findings indicate that preclinical evaluation of cardiac function is essential to develop safe and efficacious alternatives to blood transfusion.
authors.affiliation: a Department of Bioengineering , University of California , San Diego , CA , USA.
authors.forename: Eilleen S Y
authors.initials: ES
authors.lastname: Ao-Ieong
authors.affiliation: a Department of Bioengineering , University of California , San Diego , CA , USA.
authors.forename: Alexander
authors.initials: A
authors.lastname: Williams
authors.affiliation: a Department of Bioengineering , University of California , San Diego , CA , USA.
authors.forename: Vivek
authors.initials: V
authors.lastname: Jani
authors.affiliation: a Department of Bioengineering , University of California , San Diego , CA , USA.
authors.forename: Pedro
authors.initials: P
authors.lastname: Cabrales
mesh_terms: D000818:Animals; D002417:Cattle; D006224:Cricetinae; D006321:Heart / Q000187:drug effects* / Q000503:physiopathology*; D006439:Hemodynamics / Q000187:drug effects; D006454:Hemoglobins / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D010100:Oxygen / Q000378:metabolism*; D011108:Polymers / Q000494:pharmacology* / Q000627:therapeutic use; D012151:Resuscitation; D012771:Shock, Hemorrhagic / Q000097:blood / Q000378:metabolism / Q000503:physiopathology* / Q000628:therapy*
chemical_list: D006454:Hemoglobins; D011108:Polymers; C080663:polymerized bovine hemoglobin; D010100:Oxygen
keywords: Cardiac output; artificial blood; conductance catheter; hemoglobin-based oxygen carriers; hemorrhage; polymerized bovine hemoglobin; resuscitation from hemorrhagic shock