title: Pro- and Antioxidant Systems in the Lower Portion of Rat Brainstem during Hydroxybutyrate-Induced Pathological Periodic Breathing.
abstract: Activities of superoxide dismutase and catalase characterizing antioxidant status of the nervous tissue and its resistance to free radical oxidation were measured in the brainstem of rats with hydroxybutyrate-induced pathological periodic breathing. Hydroxybutyrate modified the pro- and antioxidant status in the brainstem respiratory center. It markedly inhibited catalase activity; in rats without the signs of periodic breathing, hydroxybutyrate up-regulated superoxide dismutase activity and to a lesser extent increased the resistance of the membrane structures in the medulla oblongata to induction of free radical oxidation. In rats with periodic breathing pattern, hydroxybutyrate induced more pronounced increase in the sensitivity of membrane structures in the medulla oblongata to induction of free radical oxidation.
authors.affiliation: Laboratory of General Pathology of Cardiorespiratory System, Research Institute of General Pathology and Pathological Physiology, Moscow, Russia. beta003@rambler.ru.
authors.forename: I A
authors.initials: IA
authors.lastname: Tarakanov
authors.affiliation: Laboratory of General Pathology of Cardiorespiratory System, Research Institute of General Pathology and Pathological Physiology, Moscow, Russia.
authors.forename: L N
authors.initials: LN
authors.lastname: Tikhomirova
authors.affiliation: Laboratory of Experimental Hygienic Studies, Research Institute for Complex Problems of Hygiene and Occupational Diseases, Novokuznetsk, Russia.
authors.forename: A G
authors.initials: AG
authors.lastname: Zhukova
authors.affiliation: Laboratory of General Pathology of Cardiorespiratory System, Research Institute of General Pathology and Pathological Physiology, Moscow, Russia.
authors.forename: N F
authors.initials: NF
authors.lastname: Safina
mesh_terms: D000818:Animals; D021461:Animals, Outbred Strains; D000975:Antioxidants / Q000378:metabolism*; D002374:Catalase / Q000378:metabolism*; D004417:Dyspnea / Q000139:chemically induced / Q000378:metabolism* / Q000503:physiopathology; D005609:Free Radicals / Q000378:metabolism; D006885:Hydroxybutyrates / Q000494:pharmacology*; D007275:Injections, Intravenous; D008297:Male; D008526:Medulla Oblongata / Q000187:drug effects / Q000378:metabolism*; D009942:Organometallic Compounds / Q000494:pharmacology*; D010084:Oxidation-Reduction; D051381:Rats; D056152:Respiratory Rate / Q000187:drug effects; D013482:Superoxide Dismutase / Q000378:metabolism*; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
chemical_list: D000975:Antioxidants; D005609:Free Radicals; D006885:Hydroxybutyrates; D009942:Organometallic Compounds; D017392:Thiobarbituric Acid Reactive Substances; C022826:lithium hydroxybutyrate; D002374:Catalase; D013482:Superoxide Dismutase
keywords: catalase; free radical oxidation; hydroxybutyrate; pathological periodic breathing; superoxide dismutase (SOD)