title: Usefulness of copeptin as a potential biomarker in TBE.
abstract: OBJECTIVE
  The aim of the study was to evaluate the usefulness of copeptin for differentiation of hyponatremia in the course of tick-borne encephalitis (TBE) and for being a prognostic marker of the severity of TBE.
  
  
  METHODS
  One hundred and fourteen patients with TBE were included in the study. The control group consisted of 62 patients diagnosed with viral meningitis.
  
  
  RESULTS
  Copeptin concentration did not differ in patients with hyponatremia and normonatremia. Urinary sodium excretion to plasma copeptin (copeptin/UNa Secretion) ratio was significantly lower in Syndrome of Inappropriate Antidiuretic Hormone (SIADH) Secretion patients than in patients with hyponatremia of other origin. Mean copeptin concentration in TBE patients was higher than in control group (VM) patients. There were no differences between patients with severe and mild course of TBE.
  
  
  CONCLUSIONS
  Copeptin/UNa ratio may be used as a potential biomarker of SIADH in patients with TBE. Copeptin concentration is significantly higher in patients with TBE than in viral meningitis of other origin, especially in patients aged 18-34 and >49 years old. Copeptin does not differentiate TBE of mild and severe course.
authors.affiliation: a Department of Infectious Diseases and Neuroinfections of the Medical University of Bialystok , Bialystok , Poland.
authors.forename: Piotr
authors.initials: P
authors.lastname: Czupryna
authors.affiliation: a Department of Infectious Diseases and Neuroinfections of the Medical University of Bialystok , Bialystok , Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Moniuszko-Malinowska
authors.affiliation: a Department of Infectious Diseases and Neuroinfections of the Medical University of Bialystok , Bialystok , Poland.
authors.forename: Adam
authors.initials: A
authors.lastname: Garkowski
authors.affiliation: a Department of Infectious Diseases and Neuroinfections of the Medical University of Bialystok , Bialystok , Poland.
authors.forename: Justyna
authors.initials: J
authors.lastname: Dunaj
authors.affiliation: a Department of Infectious Diseases and Neuroinfections of the Medical University of Bialystok , Bialystok , Poland.
authors.forename: Renata
authors.initials: R
authors.lastname: Swierzbinska
authors.affiliation: a Department of Infectious Diseases and Neuroinfections of the Medical University of Bialystok , Bialystok , Poland.
authors.forename: Sławomir
authors.initials: S
authors.lastname: Pancewicz
authors.affiliation: b Faculty of Computer Science , Bialystok University of Technology , Bialystok , Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Gościk
authors.affiliation: a Department of Infectious Diseases and Neuroinfections of the Medical University of Bialystok , Bialystok , Poland.
authors.forename: Maciej
authors.initials: M
authors.lastname: Kondrusik
authors.affiliation: a Department of Infectious Diseases and Neuroinfections of the Medical University of Bialystok , Bialystok , Poland.
authors.forename: Sambor
authors.initials: S
authors.lastname: Grygorczuk
authors.affiliation: a Department of Infectious Diseases and Neuroinfections of the Medical University of Bialystok , Bialystok , Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Zajkowska
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D004675:Encephalitis, Tick-Borne / Q000097:blood / Q000175:diagnosis*; D005260:Female; D006020:Glycopeptides / Q000097:blood*; D006801:Humans; D007010:Hyponatremia / Q000097:blood / Q000175:diagnosis*; D007177:Inappropriate ADH Syndrome / Q000097:blood / Q000175:diagnosis*; D008297:Male; D008587:Meningitis, Viral; D008875:Middle Aged; D011379:Prognosis; D012720:Severity of Illness Index; D012964:Sodium / Q000652:urine; D055815:Young Adult
chemical_list: D015415:Biomarkers; D006020:Glycopeptides; C048197:copeptins; D012964:Sodium
keywords: Copeptin; SIADH; TBE; copeptin to UNa ratio; hyponatremia; meningitis; tick-borne encephalitis