title: Emergence of plasmid-mediated colistin resistance and New Delhi metallo-β-lactamase genes in extensively drug-resistant Escherichia coli isolated from a patient in Thailand.
abstract: We reported a case of Escherichia coli with colistin resistance and an extensively drug-resistant phenotype. Molecular analysis revealed that the isolate carried mcr-1 and multiple β-lactamase genes includingblaNDM1, blaCTX-M-15, blaTEM1, and blaCMY-2. This is the first report of a clinical mcr-1 isolate in Thailand highlighting the urgent need for a comprehensive antimicrobial resistance containment strategy to prevent further spread.
authors.affiliation: Department of Medical Sciences, Ministry of Public Health, National Institute of Health, Bangkok, 10400, Thailand.
authors.forename: Wantana
authors.initials: W
authors.lastname: Paveenkittiporn
authors.affiliation: Faculty of Public Health, Kasetsart University Chalermphrakiat Sakon Nakhon Province Campus, Sakon Nakhon, 47000, Thailand. Electronic address: noksak99@gmail.com.
authors.forename: Anusak
authors.initials: A
authors.lastname: Kerdsin
authors.affiliation: Phetchabun Hospital, Phetchabun, Thailand.
authors.forename: Sukanya
authors.initials: S
authors.lastname: Chokngam
authors.affiliation: International Emerging Infections Program, Global Disease Detection Center, Nonthaburi, Thailand.
authors.forename: Charatdao
authors.initials: C
authors.lastname: Bunthi
authors.affiliation: Department of Medical Sciences, Ministry of Public Health, National Institute of Health, Bangkok, 10400, Thailand.
authors.forename: Somchai
authors.initials: S
authors.lastname: Sangkitporn
authors.affiliation: Division of Global Health Protection, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Gregory
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003091:Colistin / Q000494:pharmacology*; D024901:Drug Resistance, Multiple, Bacterial; D004926:Escherichia coli / Q000187:drug effects / Q000201:enzymology / Q000235:genetics / Q000302:isolation & purification*; D004927:Escherichia coli Infections / Q000382:microbiology*; D005798:Genes, Bacterial; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D060885:Multiplex Polymerase Chain Reaction; D010957:Plasmids / Q000032:analysis*; D017422:Sequence Analysis, DNA; D013785:Thailand; D001618:beta-Lactamases / Q000235:genetics*
chemical_list: D000900:Anti-Bacterial Agents; D001618:beta-Lactamases; C552864:beta-lactamase NDM-1; D003091:Colistin
keywords: Colistin resistance; XDR E.coli; mcr-1