title: Biomarkers of cardiovascular injury and stress are associated with increased frequency of ventricular ectopy: a population-based study.
abstract: Asymptomatic ventricular arrhythmias are common and associated with increased risk of cardiovascular mortality. Cardiac troponins, natriuretic peptides and C-reactive protein (CRP) are also predictive of adverse cardiovascular events in the general population, but limited information is available on the relationship between these biomarkers and ventricular ectopy in a community-based population. The objectives were to evaluate the associations between ventricular ectopic activity and N-terminal pro-B-type natriuretic peptide (NT-proBNP), high sensitivity-troponin I (hs-TnI) and hs-CRP in a community-based setting.
  
  
  
  We performed a 24 h Holter-recording and blood sampling in 498 subjects. Premature ventricular complexes (PVC) were classified as frequent at >5/h and the presence of any bigeminy, trigeminy or non-sustained ventricular tachycardia were classified as complex ventricular ectopy. The associations between biomarkers and ventricular arrhythmias were investigated by univariate and multivariate logistic regression analyses.
  
  
  
  Frequent PVC's and complex ventricular ectopy were detected in 46 (9%) and 47 (9%) participants respectively, and were associated with significantly (p < 0.001) higher concentrations of NT-proBNP and hs-TnI. The association between NT-proBNP and both frequent PVC's (p = 0.020) and complex ventricular ectopy (p = 0.001) remained significant after adjusting for conventional risk markers in multivariate analyses.
  
  
  
  Increased level of NT-proBNP was independently associated with ventricular ectopy, whereas no independent association was observed between hs-TnI and hs-CRP levels and ventricular ectopy in this community-based sample.
authors.affiliation: Division of Medicine, Akershus University Hospital, Lørenskog, Norway.
authors.forename: Julia Brox
authors.initials: JB
authors.lastname: Skranes
authors.affiliation: Division of Medicine, Akershus University Hospital, Lørenskog, Norway.
authors.forename: Gunnar
authors.initials: G
authors.lastname: Einvik
authors.affiliation: Asker and Bærum Emergency Unit, Sandvika, Norway.
authors.forename: Silje Kjeka
authors.initials: SK
authors.lastname: Namtvedt
authors.affiliation: Division of Medicine, Akershus University Hospital, Lørenskog, Norway.
authors.forename: Anna
authors.initials: A
authors.lastname: Randby
authors.affiliation: Division of Surgery, Akershus University Hospital, Lørenskog, Norge.
authors.forename: Harald
authors.initials: H
authors.lastname: Hrubos-Strøm
authors.affiliation: Division of Medicine, Akershus University Hospital, Lørenskog, Norway.
authors.forename: Jon
authors.initials: J
authors.lastname: Brynildsen
authors.affiliation: Division of Diagnostics and Technology, Akershus University Hospital, Lørenskog, Norway.|Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
authors.forename: Tor-Arne
authors.initials: TA
authors.lastname: Hagve
authors.affiliation: Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Foundation for Medical Education and Research, Rochester, MN, USA.
authors.forename: Virend K
authors.initials: VK
authors.lastname: Somers
authors.affiliation: Division of Medicine, Akershus University Hospital, Lørenskog, Norway.|Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
authors.forename: Helge
authors.initials: H
authors.lastname: Røsjø
authors.affiliation: Division of Medicine, Akershus University Hospital, Lørenskog, Norway. torbjorn.omland@medisin.uio.no.|Institute of Clinical Medicine, University of Oslo, Oslo, Norway. torbjorn.omland@medisin.uio.no.
authors.forename: Torbjørn
authors.initials: T
authors.lastname: Omland
mesh_terms: D000328:Adult; D000368:Aged; D058070:Asymptomatic Diseases; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D003430:Cross-Sectional Studies; D015716:Electrocardiography, Ambulatory; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D009664:Norway / Q000453:epidemiology; D016017:Odds Ratio; D010446:Peptide Fragments / Q000097:blood*; D012307:Risk Factors; D011795:Surveys and Questionnaires; D017180:Tachycardia, Ventricular / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology; D019210:Troponin I / Q000097:blood; D018879:Ventricular Premature Complexes / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology
chemical_list: D015415:Biomarkers; D010446:Peptide Fragments; D019210:Troponin I; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain; D002097:C-Reactive Protein
keywords: Arrhythmias; C-reactive protein; NT-proBNP; troponin I