title: Proliferative Potential of Cardiomyocytes in Hypertrophic Cardiomyopathy: Correlation with Myocardial Remodeling.
abstract: Proliferating Ki-67+cardiomyocytes were detected in the interventricular septum myocardium of adult patients with hypertrophic cardiomyopathy. In the same patients, the severity of hypertrophy and the degree of cardiomyocyte differentiation were assessed by the content of myofibrils, ultrastructural morphology, and the pattern of connexin 43-containing gap junction distribution. Adult Ki-67+cardiomyocytes containing sarcomeric α-actin (sarc α-act+) in the sarcoplasm (diameter 23.9±6.9 μ) were detected in the myocardium of patients with hypertrophic cardiomyopathy; their relative content varied from 2 to 3084 cells per 1 million cardiomyocytes. Small early differentiating Ki-67+/sarc α-act+cardiomyocytes with a thin cytoplasm layer (diameter 5.9±1.7 μ) constituted from 3 to 2262 cells per 1 million cardiomyocytes. These cells were found in the myocardium with the most pronounced structural changes: hypertrophy of cardiomyocytes with signs of their partial dedifferentiation.
authors.affiliation: A. N. Bakulev Scientific Center for Cardiovascular Surgery, Ministry of Health of the Russian Federation, Moscow, Russia. tatiana@box.ru.
authors.forename: T V
authors.initials: TV
authors.lastname: Sukhacheva
authors.affiliation: A. N. Bakulev Scientific Center for Cardiovascular Surgery, Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: Yu A
authors.initials: YA
authors.lastname: Chudinovskikh
authors.affiliation: A. N. Bakulev Scientific Center for Cardiovascular Surgery, Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: M V
authors.initials: MV
authors.lastname: Eremeeva
authors.affiliation: A. N. Bakulev Scientific Center for Cardiovascular Surgery, Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: R A
authors.initials: RA
authors.lastname: Serov
authors.affiliation: A. N. Bakulev Scientific Center for Cardiovascular Surgery, Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: L A
authors.initials: LA
authors.lastname: Bockeria
mesh_terms: D000199:Actins / Q000235:genetics / Q000378:metabolism; D000293:Adolescent; D000328:Adult; D002312:Cardiomyopathy, Hypertrophic / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D002452:Cell Count; D002454:Cell Differentiation; D049109:Cell Proliferation; D018031:Connexin 43 / Q000235:genetics / Q000378:metabolism; D005260:Female; D015870:Gene Expression; D006352:Heart Ventricles / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D006801:Humans; D019394:Ki-67 Antigen / Q000235:genetics / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D032383:Myocytes, Cardiac / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D012518:Sarcomeres / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D020257:Ventricular Remodeling
chemical_list: D000199:Actins; D018031:Connexin 43; C500216:GJA1 protein, human; D019394:Ki-67 Antigen
keywords: connexin 43; dedifferentiated cardiomyocytes; hypertrophic cardiomyopathy; myocardium of the interventricular septum; proliferative activity of cardiomyocytes