title: SEOM Clinical Guideline of management of soft-tissue sarcoma (2016).
abstract: Soft-tissue sarcomas are uncommon and heterogeneous tumors of mesenchymal origin. A soft-tissue mass that is increasing in size, greater than 5 cm, or located under deep fascia are criteria for suspicion of sarcoma. Diagnosis, treatment, and management should preferably be performed by a multidisciplinary team in reference centers. MRI and lung CT scan are mandatory for local and distant assessment. A biopsy indicating histological type and grade is needed previous to the treatment. Wide surgical resection with tumor-free tissue margin is the primary treatment for localized disease. Radiotherapy is indicated in large, deep, high-grade tumors, or after marginal resection not likely of being improved with reexcision. Neoadjuvant and adjuvant chemotherapy improve survival in selected cases, usually in high-grade sarcomas of the extremities. In the case of metastatic disease, patients with exclusive lung metastasis could be considered for surgery. First-line treatment with anthracyclines (or in combination with ifosfamide) is the treatment of choice. New drugs have shown activity in second-line therapy and in specific histological subtypes.
authors.affiliation: Servicio de Oncología Médica, Hospital de la Santa Creu i Sant Pau, Mas Casanovas 90, 08041, Barcelona, Spain. alopezp@santpau.cat.
authors.forename: A
authors.initials: A
authors.lastname: López-Pousa
authors.affiliation: Hospital Virgen del Rocio, Seville, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Martin Broto
authors.affiliation: Hospital Universitario Miguel Servet, Saragossa, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Martinez Trufero
authors.affiliation: Hospital Universitario Virgen de la Victoria, Malaga, Spain.
authors.forename: I
authors.initials: I
authors.lastname: Sevilla
authors.affiliation: Hospital Vall d'Hebro, Barcelona, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Valverde
authors.affiliation: Hospital Universitario Gregorio Marañon, Madrid, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Alvarez
authors.affiliation: Hospital Universitario de Vigo, Vigo, Spain.
authors.forename: J A
authors.initials: JA
authors.lastname: Carrasco Alvarez
authors.affiliation: Hospital Universitario de Canarias, Tenerife, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Cruz Jurado
authors.affiliation: Hospital Virgen del Rocio, Seville, Spain.
authors.forename: N
authors.initials: N
authors.lastname: Hindi
authors.affiliation: Hospital Duran I Reynals, Hospitalet de Llobregat, Spain.
authors.forename: X
authors.initials: X
authors.lastname: Garcia Del Muro
mesh_terms: D006801:Humans; D060787:Neoplasm Grading; D009362:Neoplasm Metastasis; D017410:Practice Guidelines as Topic; D012509:Sarcoma / Q000175:diagnosis* / Q000628:therapy*; D012983:Soft Tissue Neoplasms / Q000175:diagnosis* / Q000628:therapy*; D013030:Spain
keywords: Clinical guidelines; Sarcoma; Soft-tissue tumors; Uncommon tumors