title: Primate Neurons Flex Their Musclin.
abstract: Sensory experience evokes long-lasting changes in neural circuits through activity-dependent gene expression. Ataman et al. (2016) report in Nature that primates evolved novel transcriptional responses to neuronal activity, including induction of musclin/osteocrin (OSTN), which may regulate specialized aspects of primate neural circuits.
authors.affiliation: Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address: pollena@stemcell.ucsf.edu.
authors.forename: Alex A
authors.initials: AA
authors.lastname: Pollen
authors.affiliation: Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA.
authors.forename: Arnold R
authors.initials: AR
authors.lastname: Kriegstein
mesh_terms: D000818:Animals; D015870:Gene Expression; D009124:Muscle Proteins / Q000235:genetics*; D009474:Neurons; D011323:Primates / Q000235:genetics
chemical_list: D009124:Muscle Proteins
keywords: MEF2C; NPR3; OSTN; activity-dependent gene expression; osteocrin/musclin; primate neocortex evolution