title: Effect of systemic enzymotherapy on Cesarean section scar healing.
abstract: OBJECTIVE
  The aim of our study was to monitor changes in the healing of Caesarean section scars in patients using systemic enzymotherapy in comparison with patients not treated with systemic enzymotherapy (Wobenzym).
  
  
  METHODS
  A prospective cohort study was conducted in 60 primiparous women delivered by CS. We compared the following outcomes: scar thickness after the Caesarean section, dehiscence risk coefficient (DRC), severity of the Caesarean section scar defect, uterine cavity dilation, post-operative pain, C-reactive protein level and febrility.
  
  
  RESULTS
  The scar thickness 6 weeks after CS was significantly greater in the group of patients taking Wobenzym (7.1±0.9 mm; mean ± SD) than in the patients without Wobenzym (5.3±0.7 mm) (p = 0.01). Severe Caesarean section scar defects were observed in 1/30 (3.3%) Wobenzym users and in 5/30 (16.7%) patients who did not use Wobenzym, with no statistically significant difference (p = 0.195).
  
  
  CONCLUSIONS
  Despite the percentage of patients with a severe CS scar defect being apparently lower in the group treated with Wobenzym, the difference did not reach statistical significance due to the small size of the study population.
authors.forename: E
authors.initials: E
authors.lastname: Dosedla
authors.forename: A
authors.initials: A
authors.lastname: Grendelova
authors.forename: P
authors.initials: P
authors.lastname: Calda
mesh_terms: D000328:Adult; D002585:Cesarean Section; D002921:Cicatrix / Q000188:drug therapy*; D015331:Cohort Studies; D004338:Drug Combinations; D057487:Enzyme Therapy / Q000379:methods*; D005260:Female; D006801:Humans; D006867:Hydrolases / Q000627:therapeutic use*; D011183:Postoperative Complications / Q000188:drug therapy*; D011247:Pregnancy; D011446:Prospective Studies; D012306:Risk; D012431:Rutin / Q000627:therapeutic use*; D013529:Surgical Wound Dehiscence / Q000517:prevention & control; D014945:Wound Healing / Q000187:drug effects
chemical_list: D004338:Drug Combinations; D012431:Rutin; C023295:Wobenzym; D006867:Hydrolases
keywords: Caesarean section; enzymotherapy; ultrasound Cesarean section scar.