title: Antigen presentation for priming T cells in central system.
abstract: Generation of myelin antigen-specific T cells is a major event in neuroimmune responses that causes demyelination. The antigen-priming of T cells and its location is important in chronic and acute inflammation. In autoimmune multiple sclerosis, the effector T cells are considered to generate in periphery. However, the reasons for chronic relapsing-remitting events are obscure. Considering mechanisms, a feasible aim of research is to investigate the role of antigen-primed T cells in lupus cerebritis. Last thirty years of investigations emphasize the relevance of microglia and infiltrated dendritic cells/macrophages as antigen presenting cells in the central nervous system. The recent approach towards circulating B-lymphocytes is an important area in the context. Here, we analyze the existing findings on antigen presentation in the central nervous system. The aim is to visualize signaling events of myelin antigen presentation to T cells and lead to the strategy of future goals on immunotherapy research.
authors.affiliation: Academic Magnet High School, Charleston, SC, United States. Electronic address: shaonidasgupta@outlook.com.
authors.forename: Shaoni
authors.initials: S
authors.lastname: Dasgupta
authors.affiliation: Microbiology, Immunology and Biochemistry, Saint James School of Medicine, P.O. Box 318, Albert Lake Drive, The Quarter, AI-2640, British West Indies, Anguilla. Electronic address: subhajitdasgupta@outlook.com.
authors.forename: Subhajit
authors.initials: S
authors.lastname: Dasgupta
mesh_terms: D000818:Animals; D017951:Antigen Presentation; D000938:Antigen-Presenting Cells / Q000166:cytology / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D020274:Autoimmune Diseases of the Nervous System / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D002490:Central Nervous System / Q000166:cytology / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D003713:Dendritic Cells / Q000166:cytology / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008264:Macrophages / Q000166:cytology / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D017628:Microglia / Q000166:cytology / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D018448:Models, Immunological; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology* / Q000378:metabolism / Q000473:pathology
keywords: Antigen; Central nervous system; Dendritic cells; Lymphocyte; MHC