title: Preparation and characterization of multifunctional magnetic mesoporous calcium silicate materials.
abstract: We have prepared multifunctional magnetic mesoporous Fe-CaSiO3materials using triblock copolymer (P123) as a structure-directing agent. The effects of Fe substitution on the mesoporous structure,in vitrobioactivity, magnetic heating ability and drug delivery property of mesoporous CaSiO3materials were investigated. Mesoporous Fe-CaSiO3materials had similar mesoporous channels (5-6 nm) with different Fe substitution. When 5 and 10% Fe were substituted for Ca in mesoporous CaSiO3materials, mesoporous Fe-CaSiO3materials still showed good apatite-formation ability and had no cytotoxic effect on osteoblast-like MC3T3-E1 cells evaluated by the elution cell culture assay. On the other hand, mesoporous Fe-CaSiO3materials could generate heat to raise the temperature of the surrounding environment in an alternating magnetic field due to their superparamagnetic property. When we use gentamicin (GS) as a model drug, mesoporous Fe-CaSiO3materials release GS in a sustained manner. Therefore, magnetic mesoporous Fe-CaSiO3materials would be a promising multifunctional platform with bone regeneration, local drug delivery and magnetic hyperthermia.
authors.affiliation: School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, 516 Jungong Road, Shanghai 200093, People's Republic of China.
authors.forename: Jianhua
authors.initials: J
authors.lastname: Zhang
authors.affiliation: School of Materials Science and Engineering, University of Shanghai for Science and Technology, 516 Jungong Road, Shanghai 200093, People's Republic of China.
authors.forename: Yufang
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: Interdisciplinary Laboratory for Nanoscale Science and Technology, National Institute for Materials Science, 1-2-1 Sengen, Tsukuba, Ibaraki 305-0047, Japan.
authors.forename: Jie
authors.initials: J
authors.lastname: Li
authors.affiliation: School of Materials Science and Engineering, University of Shanghai for Science and Technology, 516 Jungong Road, Shanghai 200093, People's Republic of China.
authors.forename: Min
authors.initials: M
authors.lastname: Zhu
authors.affiliation: School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, 516 Jungong Road, Shanghai 200093, People's Republic of China.
authors.forename: Cuilian
authors.initials: C
authors.lastname: Tao
authors.affiliation: Interdisciplinary Laboratory for Nanoscale Science and Technology, National Institute for Materials Science, 1-2-1 Sengen, Tsukuba, Ibaraki 305-0047, Japan.
authors.forename: Nobutaka
authors.initials: N
authors.lastname: Hanagata
keywords: bone regeneration; drug delivery; magnetic hyperthermia; mesoporous calcium silicate