title: Quantifying the effect of adipose tissue in muscle oximetry by near infrared spectroscopy.
abstract: Change of muscle tissue oxygen saturation (StO2), due to exercise, measured by near infrared spectroscopy (NIRS) is known to be lower for subjects with higher adipose tissue thickness. This is most likely not physiological but caused by the superficial fat and adipose tissue. In this paper we assessed, in vitro, the influence of adipose tissue thickness on muscleStO2, measured by NIRS oximeters. We measuredStO2of a liquid phantom by 3 continuous wave (CW) oximeters (Sensmart Model X-100 Universal Oximetry System, INVOS 5100C, and OxyPrem v1.3), as well as a frequency-domain oximeter, OxiplexTS, through superficial layers with 4 different thicknesses. Later, we employed the results to calibrate OxyPrem v1.3 for adipose tissue thickness in-vivo.
authors.affiliation: Biomedical Optics Research Laboratory, Department of Neonatology, University Hospital Zurich, Zurich, Switzerland; equal contribution; nassim.nasseri@usz.ch.
authors.forename: Nassim
authors.initials: N
authors.lastname: Nasseri
authors.affiliation: Biomedical Optics Research Laboratory, Department of Neonatology, University Hospital Zurich, Zurich, Switzerland; equal contribution.
authors.forename: Stefan
authors.initials: S
authors.lastname: Kleiser
authors.affiliation: Biomedical Optics Research Laboratory, Department of Neonatology, University Hospital Zurich, Zurich, Switzerland.
authors.forename: Daniel
authors.initials: D
authors.lastname: Ostojic
authors.affiliation: Department of Neonatology, University Hospital Zurich, Zurich, Switzerland.
authors.forename: Tanja
authors.initials: T
authors.lastname: Karen
authors.affiliation: Biomedical Optics Research Laboratory, Department of Neonatology, University Hospital Zurich, Zurich, Switzerland.
authors.forename: Martin
authors.initials: M
authors.lastname: Wolf
keywords: (120.3890) Medical optics instrumentation; (170.6510) Spectroscopy, tissue diagnostics