title: Plasma Sfrp5 and adiponectin levels in relation to blood pressure among obese children.
abstract: The aim was to clarify the associations of five adipocytokines: Sfrp5, Wnt5a, adiponectin, chemerin and high-sensitivity C-reactive protein (hsCRP) with blood pressure (BP), and to examine whether BP can be influenced by changes in these adipocytokines in obese children after a 6-month lifestyle intervention. We conducted a cross-sectional study in 263 obese children and performed a 6-month lifestyle intervention in a subgroup of 89 obese children with hypertension. Anthropometric data, adiponectin, chemerin, Sfrp5 and Wnt5a were assessed at baseline and after 6-month lifestyle intervention. Sfrp5 and adiponectin serum levels were significantly lower in obese children with hypertension, but Wnt5a, hsCRP and chemerin serum levels were elevated in obese children with hypertension. In multivariable linear regression analysis, Sfrp5, Wnt5a, adiponectin, chemerin and hsCRP were associated with both standard deviation score-systolic blood pressure (SDS-SBP) and -diastolic blood pressure (SDS-DBP). Lifestyle intervention resulted in a significant improvement in BP and weight loss. These were accompanied by significant decreases in hsCRP and chemerin, and significant increases in Sfrp5 and adiponectin, whereas Wnt5a was not changed. Furthermore, the changes in Sfrp5 and adiponectin act as partial mediators of the relationship between weight loss and BP reduction after controlling for covariates. Although Sfrp5, Wnt5a, adiponectin, chemerin and hsCRP levels are correlated with BP at baseline, after lifestyle intervention, the relationship between weight loss and BP reduction were partially mediated by changes in Sfrp5 and adiponectin after controlling for covariates. So we speculate that Sfrp5 and adiponectin may have some influence on BP.
authors.affiliation: Department of Pediatrics, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shan Xi, People's Republic of China.
authors.forename: C
authors.initials: C
authors.lastname: Yin
authors.affiliation: Department of Pediatrics, The First Hospital of Xi'an, Xi'an, Shan Xi, People's Republic of China.
authors.forename: H
authors.initials: H
authors.lastname: Chu
authors.affiliation: Department of Endocrinology and Metabolism, The Children's Hospital of Xi'an, Xi'an, Shan Xi, People's Republic of China.
authors.forename: H
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Pediatrics, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shan Xi, People's Republic of China.
authors.forename: Y
authors.initials: Y
authors.lastname: Xiao
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D054392:Adipokines / Q000097:blood; D052242:Adiponectin / Q000097:blood*; D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure; D002097:C-Reactive Protein / Q000378:metabolism; D018925:Chemokines / Q000097:blood; D002648:Child; D003430:Cross-Sectional Studies; D005136:Eye Proteins / Q000097:blood*; D005260:Female; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood; D008297:Male; D008565:Membrane Proteins / Q000097:blood*; D009765:Obesity / Q000097:blood* / Q000178:diet therapy; D040242:Risk Reduction Behavior; D015431:Weight Loss; D061217:Weight Reduction Programs; D000071818:Wnt-5a Protein / Q000097:blood; D000094742:Secreted Frizzled-Related Proteins
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D054392:Adipokines; D052242:Adiponectin; D015415:Biomarkers; D002097:C-Reactive Protein; D018925:Chemokines; D005136:Eye Proteins; D036341:Intercellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D000071818:Wnt-5a Protein; C478630:RARRES2 protein, human; C118511:SFRP5 protein, human; D000094742:Secreted Frizzled-Related Proteins; C085389:WNT5A protein, human