title: Diagnostic and Prognostic Value of Plasma Levels of Cardiac Myosin Binding Protein-C as a Novel Biomarker in Heart Failure.
abstract: Heart failure (HF) has high morbidity and mortality in children. This study aimed to investigate the value of cardiac myosin binding protein-C (cMyBP-C) as a diagnostic and prognostic biomarker in children with heart failure. This study was a prospective case-control study that involved 50 children with acute HF and 25 healthy children of matched age and sex as a control group. cMyBP-C plasma levels were measured in patients with HF at the time of admission and 1 month after treatment. Echocardiographic assessment was done for all children. All patients were followed up for a period of 3 months. There was a significant increase in plasma levels of cMyBP-C (ng/ml) in patients with HF at admission (122.44 ± 41.01) as compared to patients after treatment (71.38 ± 49.68) and to control group (24.40 ± 9.83). This increase was associated with increased severity of HF according to pediatric Ross classification of HF. Significant increase in plasma levels of cMyBP-C at admission and its persistent increase after treatment were associated with adverse outcome of mortality and readmission. Plasma levels of cMyBP-C were significantly correlated with echocardiographic and clinical assessment of heart failure. Plasma levels of cMyBP-C were a good biomarker for diagnosis of HF with sensitivity 100% and specificity 96% at cutoff point of 45 ng/ml. Its value in predicting adverse outcome in HF patients was obtained by ROC curve with sensitivity of 90% and specificity 93% at a cutoff point of 152 ng/ml cMyBP-C at admission. cMyBP-C may be a novel useful diagnostic and prognostic biomarker in children with heart failure and determination of severity of HF in these patients.
authors.affiliation: Pediatric Department, Tanta University Hospital, El Motasem Street, Tanta, Egypt. doaamoha@yahoo.com.
authors.forename: Doaa
authors.initials: D
authors.lastname: El Amrousy
authors.affiliation: Clinical Pathology Department, Tanta University Hospital, Tanta, Egypt.
authors.forename: Hossam
authors.initials: H
authors.lastname: Hodeib
authors.affiliation: Clinical Pathology Department, Tanta University Hospital, Tanta, Egypt.
authors.forename: Ghada
authors.initials: G
authors.lastname: Suliman
authors.affiliation: Pediatric Department, Tanta University Hospital, El Motasem Street, Tanta, Egypt.
authors.forename: Nahed
authors.initials: N
authors.lastname: Hablas
authors.affiliation: Anesthesiology and ICU Department, Tanta University Hospital, Tanta, Egypt.
authors.forename: Eman Ramadan
authors.initials: ER
authors.lastname: Salama
authors.affiliation: Anesthesiology and ICU Department, Tanta University Hospital, Tanta, Egypt.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Esam
mesh_terms: D015415:Biomarkers / Q000097:blood; D002352:Carrier Proteins / Q000097:blood*; D016022:Case-Control Studies; D002675:Child, Preschool; D005260:Female; D006330:Heart Defects, Congenital / Q000150:complications*; D006333:Heart Failure / Q000175:diagnosis* / Q000401:mortality*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D053208:Kaplan-Meier Estimate; D008297:Male; D011379:Prognosis; D011446:Prospective Studies; D012372:ROC Curve; D012680:Sensitivity and Specificity; D000099163:Myosin Binding Protein C
chemical_list: D015415:Biomarkers; D002352:Carrier Proteins; D000099163:Myosin Binding Protein C
keywords: Children; Heart failure; cMyBP-C