title: Molecular Recognition and Specific Interactions for Biosensing Applications.
abstract: Molecular recognition and specific interactions are reliable and versatile routes for site-specific and well-oriented immobilization of functional biomolecules on surfaces. The control of surface properties via the molecular recognition and specific interactions at the nanoscale is a key element for the nanofabrication of biosensors with high sensitivity and specificity. This review intends to provide a comprehensive understanding of the molecular recognition- and specific interaction-mediated biosensor fabrication routes that leads to biosensors with well-ordered and controlled structures on both nanopatterned surfaces and nanomaterials. Herein self-assembly of the biomolecules via the molecular recognition and specific interactions on nanoscaled surfaces as well as nanofabrication techniques of the biomolecules for biosensor architecture are discussed. We also describe the detection of molecular recognition- and specific interaction-mediated molecular binding as well as advantages of nanoscale detection.
authors.affiliation: BK 21 Physics Research Division, Institute of Basic Science, SKKU Advanced Institute of Nanotechnology, Center for Nanotubes and Nanostructured Composites, Sungkyunkwan University, Suwon 440-746, Korea. kimdc@skku.edu.
authors.forename: Dong Chung
authors.initials: DC
authors.lastname: Kim
authors.affiliation: BK 21 Physics Research Division, Institute of Basic Science, SKKU Advanced Institute of Nanotechnology, Center for Nanotubes and Nanostructured Composites, Sungkyunkwan University, Suwon 440-746, Korea. djkang@skku.edu.
authors.forename: Dae Joon
authors.initials: DJ
authors.lastname: Kang
keywords: Molecular recognition; biosensor; nanomaterial; nanopatterning; specific interaction