title: Lutetium 177-DOTA-TATE therapy for esthesioneuroblastoma: A case report.
abstract: Esthesioneuroblastoma (ENB), also known as olfactory neuroblastoma, is a rare malignant tumor that accounts for 3% of all tumors of the nasal cavity. The incidence of ENB is 0.4 cases per million in the general population, and the most common symptoms are nasal obstruction and epistaxis. Previous studies have indicated the presence of somatostatin receptors in this tumor type. Common treatment strategies for ENB include resection and adjuvant radiotherapy and/or chemotherapy (combined treatment); however, the rate of recurrence is high. Treatment of neuroendocrine tumors using radionuclides bound to somatostatin analogues is well established in clinical practice. However, a standard and effective therapeutic approach has not been reported for ENB. The current study described the case of a 74-year-old female with numerous recurrences of ENB following multiple treatments and without possibility of resection. The patient was treated with the radiolabeled-somatostatin analogue,177Lutetium-DOTA-octreotate (177Lu-DOTA-TATE), which successfully controlled the disease. This suggests that177Lu-DOTA-TATE is a potential treatment for ENB and may represent an effective alternative and novel therapeutic strategy for this disease.
authors.affiliation: Imaging Medical Center, Division of Nuclear Medicine, Medical Centre of Sorocaba, Sorocaba, SP 18031-480, Brazil.
authors.forename: Juliano Guerra
authors.initials: JG
authors.lastname: Sabongi
authors.affiliation: Department of Nuclear Medicine, Barretos Cancer Hospital, Barretos, SP 14780-000, Brazil.
authors.forename: Mônica Carboni Pereira
authors.initials: MC
authors.lastname: Gonçalves
authors.affiliation: Department of Head and Neck Surgery, Barretos Cancer Hospital, Barretos, SP 14780-000, Brazil.
authors.forename: Cira Danielle Casado
authors.initials: CD
authors.lastname: Alves
authors.affiliation: Department of Nuclear Medicine, Dr Ary Pinheiro Base Hospital, Porto Velho, RO 76804-373, Brazil.
authors.forename: João
authors.initials: J
authors.lastname: Alves
authors.affiliation: Department of Pathological Anatomy, Barretos Cancer Hospital, Barretos, SP 18600-000, Brazil.
authors.forename: Cristovam
authors.initials: C
authors.lastname: Scapulatempo-Neto
authors.affiliation: Department of Tropical Diseases and Diagnostic Imaging, Botucatu Medical School, São Paulo State University, Botucatu, SP 18618-970, Brazil.
authors.forename: Sonia Marta
authors.initials: SM
authors.lastname: Moriguchi
keywords: esthesioneuroblastoma; lutetium 177; neuroendocrine tumors; nuclear medicine; olfactory neuroblastoma; radioisotopes