title: Ventral Striatum Functional Connectivity during Rewards and Losses and Symptomatology in Depressed Patients.
abstract: The ventral striatum (VS) and striatal network supports goal motivated behavior. Identifying how depressed patients differ in their striatal network during the processing of emotionally salient events is a step towards uncovering biomarkers for diagnosis and treatment.
  
  
  
  38 depressed and 30 healthy adults completed a task that examined brain activation to the anticipation and receipt of monetary rewards and losses. Data were collected using a 3T Siemens Trio scanner. Functional connectivity differences were examined with seeds in the Left or Right VS. FC estimates were regressed on specific symptoms.
  
  
  
  Depressed patients displayed higher functional connectivity between the VS and midline cortical areas during loss versus reward trials. Anhedonia and depressed mood were associated to fairly similar striatal circuits but suicidality was associated to a unique VS-midline structures coupling, while depression severity was linked to higher VS to caudate and precuneus connectivity during loss versus reward trials.
  
  
  
  Depression is characterized by excessive VS coupling to cognitive control and associative networks during losses versus rewards. High VS to midline cortical structures coupling may index suicidality.
authors.affiliation: University of Minnesota, Department of Psychiatry, MN, USA. Electronic address: queve001@umn.edu.
authors.forename: Karina
authors.initials: K
authors.lastname: Quevedo
authors.affiliation: University of Minnesota, Institute of Child Development, 51 East River Road, Minneapolis, MN, 55455, USA. Electronic address: rowenang@umn.edu.
authors.forename: Rowena
authors.initials: R
authors.lastname: Ng
authors.affiliation: University of Minnesota, Department of Psychiatry, MN, USA. Electronic address: hlscott@umn.edu.
authors.forename: Hannah
authors.initials: H
authors.lastname: Scott
authors.affiliation: University of Pittsburgh, School of Public Health, PA, USA. Electronic address: srk37@pitt.edu.
authors.forename: Srivastava
authors.initials: S
authors.lastname: Kodavaganti
authors.affiliation: University of Pittsburgh, School of Public Health, PA, USA. Electronic address: gwsmyda@gmail.com.
authors.forename: Garry
authors.initials: G
authors.lastname: Smyda
authors.affiliation: Dept. of Psychiatry & Behavioral Neurosciences, Wayne State University School of Medicine, Suite 5B, Tolan Park Medical Building, 3901 Chrysler Service Drive, Detroit, MI, 48201, USA. Electronic address: vdiwadka@med.wayne.edu.
authors.forename: Vaibhav
authors.initials: V
authors.lastname: Diwadkar
authors.affiliation: Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. Electronic address: phillipsml@upmc.edu.
authors.forename: Mary
authors.initials: M
authors.lastname: Phillips
mesh_terms: D000328:Adult; D059445:Anhedonia / Q000502:physiology*; D002540:Cerebral Cortex / Q000503:physiopathology*; D063132:Connectome / Q000379:methods*; D003863:Depression / Q000503:physiopathology*; D056344:Executive Function / Q000502:physiology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D012201:Reward; D059020:Suicidal Ideation; D066328:Ventral Striatum / Q000503:physiopathology*
keywords: Adults; Anhedonia; Corticostriatal network; Depressed mood; Depression; Functional connectivity; Imaging; Reward circuitry; Suicidality; Ventral striatum