title: The bone marrow pericyte: an orchestrator of vascular niche.
abstract: The concept of pericyte has been changing over years. This cell type was believed to possess only a function of trophic support to endothelial cells and to maintain vasculature stabilization. In the last years, the discovery of multipotent ability of perivascular populations led to the concept of vessel/wall niche. Likewise, several perivascular populations have been identified in animal and human bone marrow. In this review, we provide an overview on bone marrow perivascular population, their cross-talk with other niche components, relationship with bone marrow stromal stem cells, and similarities and differences with the perivascular population of the vessel/wall niche. Finally, we focus on the regenerative potential of these cells and the forthcoming challenges related to their use as cell therapy products.
authors.affiliation: Division of Experimental Cardiovascular Medicine, Bristol Heart Institute, University of Bristol, UK.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Mangialardi
authors.affiliation: Division of Experimental Cardiovascular Medicine, Bristol Heart Institute, University of Bristol, UK.
authors.forename: Andrea
authors.initials: A
authors.lastname: Cordaro
authors.affiliation: Division of Experimental Cardiovascular Medicine, Bristol Heart Institute, University of Bristol, UK.
authors.forename: Paolo
authors.initials: P
authors.lastname: Madeddu
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000098:blood supply*; D002454:Cell Differentiation; D002478:Cells, Cultured; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D020286:Pericytes / Q000166:cytology*; D055153:Stem Cell Niche / Q000502:physiology*
keywords: CD146; Nestin; bone marrow; endosteal niche; perivascular cell; vascular niche