title: [Factors associated with success of a smoking cessation program].
abstract: BACKGROUND
  Smoking cessation therapies include counseling, psychological management and pharmacological therapy. Varenicline is the most effective and safe medication available.
  
  
  OBJECTIVE
  To study risk factors for the failure of pharmacological smoking cessation therapy with varenicline.
  
  
  METHODS
  Retrospective analysis of 281 patients aged 45 ± 11 years (65% males) with a mean consumption of 31 ± 22 packs/year. They completed a smoking cessation program comprising psychological support and use of varenicline in a private clinic. Patients were followed with telephonic interviews during one year. A complete abstinence during one year was considered as a success of the program.
  
  
  RESULTS
  The success rate of the program was 53.4%. The factors associated with failure were a high tobacco dependence rate determined with the Fageström test (Odds ratio (OR) 2.47, 95% confidence intervals (CI) 1.16-5.26, p = 0.02). An instruction level of more than 12 years was associated with a lower failure rate (OR 0.38 95% CI 0.18-0.82).
  
  
  CONCLUSIONS
  A high tobacco dependence rate and a lower education were associated with a higher failure rate of this smoking cessation program.
authors.forename: Pedro
authors.initials: P
authors.lastname: Peña
authors.forename: Mónica
authors.initials: M
authors.lastname: Zagolin
authors.forename: Mónica
authors.initials: M
authors.lastname: Acuña
authors.forename: Sandra
authors.initials: S
authors.lastname: Navarrete
authors.forename: Pilar
authors.initials: P
authors.lastname: Bustamante
authors.forename: Andrea
authors.initials: A
authors.lastname: Canals
mesh_terms: D000328:Adult; D017668:Age of Onset; D000368:Aged; D004522:Educational Status; D004812:Epidemiologic Methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009313:National Health Programs / Q000592:standards; D018722:Nicotinic Agonists / Q000627:therapeutic use*; D015397:Program Evaluation; D012907:Smoking / Q000009:adverse effects / Q000188:drug therapy* / Q000523:psychology; D016540:Smoking Cessation / Q000379:methods* / Q000523:psychology; D016896:Treatment Outcome; D000068580:Varenicline / Q000627:therapeutic use*
chemical_list: D018722:Nicotinic Agonists; D000068580:Varenicline