title: Proinflammatory Cytokines as Regulators of Vaginal Microbiota.
abstract: It was shown that IL-1β, IL-8, and IL-6 in concentrations similar to those in the vagina of healthy women stimulated the growth of normal microflora (Lactobacillus spp.) and suppressed the growth and biofilm production by S. aureus and E. coli. On the contrary, these cytokines in higher concentrations typical of vaginal dysbiosis suppressed normal microflora and stimulated the growth of opportunistic microorganisms. TGF-β1 in both doses produced a stimulating effects on study vaginal microsymbionts. It is hypothesized that pro-inflammatory cytokines serve as the molecules of interspecies communication coordinating the interactions of all components of the vaginal symbiotic system.
authors.affiliation: Institute of Cellular and Intracellular Symbiosis, Ural Division of the Russian Academy of Sciences, Orenburg, Russia. kremlena1@mail.ru.|Orenburg State Medical University, Ministry of Healthcare of the Russian Federation, Orenburg, Russia. kremlena1@mail.ru.
authors.forename: E A
authors.initials: EA
authors.lastname: Kremleva
authors.affiliation: Institute of Cellular and Intracellular Symbiosis, Ural Division of the Russian Academy of Sciences, Orenburg, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Sgibnev
mesh_terms: D000328:Adult; D003352:Corynebacterium / Q000187:drug effects / Q000254:growth & development; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development / Q000472:pathogenicity; D005260:Female; D015870:Gene Expression; D054884:Host-Pathogen Interactions; D006801:Humans; D053583:Interleukin-1beta / Q000235:genetics / Q000276:immunology* / Q000494:pharmacology; D015850:Interleukin-6 / Q000235:genetics / Q000276:immunology* / Q000494:pharmacology; D016209:Interleukin-8 / Q000235:genetics / Q000276:immunology* / Q000494:pharmacology; D007778:Lactobacillus / Q000187:drug effects / Q000254:growth & development; D008826:Microbial Sensitivity Tests; D064307:Microbiota / Q000276:immunology*; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development / Q000472:pathogenicity; D053773:Transforming Growth Factor beta1 / Q000235:genetics / Q000276:immunology* / Q000494:pharmacology; D014621:Vagina; D016585:Vaginosis, Bacterial / Q000382:microbiology* / Q000473:pathology
chemical_list: C508585:IL1B protein, human; C508600:IL6 protein, human; D053583:Interleukin-1beta; D015850:Interleukin-6; D016209:Interleukin-8; D053773:Transforming Growth Factor beta1
keywords: Lactobacillus; biofilms; cytokines; female reproductive tract; host—parasite interactions