title: Characteristics of Lipoprotein(a)-Containing Circulating Immune Complexes as Markers of Coronary Heart Disease.
abstract: We studied the composition of circulating immune complexes precipitated in the presence of various concentrations of polyethylene glycol in patients with coronary heart disease (CHD) and high concentration of lipoprotein(a) - Lp(a). Precipitation of highly purified Lp(a) preparation with polyethylene glycol was evaluated. The contents of Lp(a), autoantibodies to Lp(a), IgG, and IgM in circulating immune complexes isolated from the sera of donors and CHD patients with normal and high levels of Lp(a) were measured. Circulating immune complexes containing Lp(a) were detected in the plasma of CHD patients with high Lp(a) concentrations. The presence of high concentrations of Lp(a), autoantibodies to Lp(a), and circulating immune complexes in CHD patients suggests that immunological factor contributes to high atherothrombogenicity of Lp(a).
authors.affiliation: Russian Cardiology Research and Production Center, Ministry of Health of the Russian Federation, Moscow, Russia. hea@mail.ru.
authors.forename: E A
authors.initials: EA
authors.lastname: Klesareva
authors.affiliation: Russian Cardiology Research and Production Center, Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: O I
authors.initials: OI
authors.lastname: Afanas'eva
authors.affiliation: Russian Cardiology Research and Production Center, Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: V V
authors.initials: VV
authors.lastname: Donskikh
authors.affiliation: Russian Cardiology Research and Production Center, Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: I Yu
authors.initials: IY
authors.lastname: Adamova
authors.affiliation: Russian Cardiology Research and Production Center, Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: S N
authors.initials: SN
authors.lastname: Pokrovskii
mesh_terms: D000936:Antigen-Antibody Complex / Q000097:blood*; D053299:Apolipoprotein B-100 / Q000097:blood; D050197:Atherosclerosis / Q000097:blood / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D001323:Autoantibodies / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D011232:Chemical Precipitation; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D015243:Cholesterol, VLDL / Q000097:blood; D003324:Coronary Artery Disease / Q000097:blood / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D017270:Lipoprotein(a) / Q000097:blood*; D011092:Polyethylene Glycols / Q000737:chemistry; D014280:Triglycerides / Q000097:blood
chemical_list: D000936:Antigen-Antibody Complex; D053299:Apolipoprotein B-100; D001323:Autoantibodies; D015415:Biomarkers; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D015243:Cholesterol, VLDL; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D017270:Lipoprotein(a); D014280:Triglycerides; C000595215:Polyethylene Glycol 6000; D011092:Polyethylene Glycols
keywords: atherosclerosis; autoantibodies; circulating immune complexes; coronary heart disease; lipoprotein(a)