title: Recurrent Osteosarcoma Presenting as an Isolated Bone Marrow Relapse.
abstract: Osteosarcoma (OS) is a malignant bone tumor which is found primarily in adolescents, with the distal femur as the most common location. OS with a jaw primary is present in only about 10% of cases and the risk of recurrence is considered to be decreased in the jaw versus other primary locations. We present a unique case of a patient with localized OS of the jaw with an isolated recurrence in her bone marrow almost 5 years after completion of initial treatment.
authors.affiliation: Departments of *Pediatrics §Medical Imaging ∥Pediatrics, Division of Hematology/Oncology/BMT, University of Arizona, Tucson ‡Department of Laboratory Medicine and Pathology, Mayo Clinic, Scottsdale, AZ †Department of Medicine, Division of Hematology/Oncology, University of Washington, Seattle, WA.
authors.forename: Julia
authors.initials: J
authors.lastname: Liu
authors.forename: Lee
authors.initials: L
authors.lastname: Cranmer
authors.forename: Brandon T
authors.initials: BT
authors.lastname: Larsen
authors.forename: Phillip H
authors.initials: PH
authors.lastname: Kuo
authors.forename: Lisa M
authors.initials: LM
authors.lastname: Kopp
mesh_terms: D000293:Adolescent; D001853:Bone Marrow / Q000473:pathology; D019046:Bone Marrow Neoplasms / Q000175:diagnosis*; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007573:Jaw Neoplasms / Q000175:diagnosis*; D009364:Neoplasm Recurrence, Local; D012516:Osteosarcoma / Q000175:diagnosis* / Q000473:pathology; D010198:Pancytopenia; D016283:Proto-Oncogene Proteins p21(ras) / Q000235:genetics; D012008:Recurrence
chemical_list: C117307:KRAS protein, human; D016283:Proto-Oncogene Proteins p21(ras)