title: Aspirin-Exacerbated Respiratory Disease.
abstract: Aspirin-exacerbated respiratory disease (AERD) is characterized by the triad of asthma, sinonasal polyposis, and aspirin intolerance. The hallmark of the disease is baseline overproduction of cysteinyl leukotrienes via the 5-lipoxygenase pathway, exacerbated by ingestion of aspirin. Patients with AERD have high rates of recidivistic polyposis following sinus surgery, although the improvement in quality of life following surgery is similar to aspirin-tolerant patients. The diagnosis is secured by a positive aspirin provocation test, usually administered by a medical allergist. Aspirin therapy is a unique treatment consideration for patients with AERD.
authors.affiliation: Department of Otolaryngology/Head and Neck Surgery, Stanford School of Medicine, Stanford Sinus Center, 801 Welch Road, Palo Alto, CA 94304, USA.
authors.forename: Evan S
authors.initials: ES
authors.lastname: Walgama
authors.affiliation: Department of Otolaryngology/Head and Neck Surgery, Stanford School of Medicine, Stanford Sinus Center, 801 Welch Road, Palo Alto, CA 94304, USA. Electronic address: hwangph@stanford.edu.
authors.forename: Peter H
authors.initials: PH
authors.lastname: Hwang
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000494:pharmacology; D001094:Arachidonate 5-Lipoxygenase / Q000378:metabolism; D001241:Aspirin / Q000009:adverse effects / Q000494:pharmacology; D055963:Asthma, Aspirin-Induced / Q000175:diagnosis / Q000378:metabolism / Q000628:therapy; D019468:Disease Management; D006801:Humans; D015289:Leukotrienes / Q000378:metabolism; D009298:Nasal Polyps / Q000209:etiology / Q000378:metabolism / Q000628:therapy
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D015289:Leukotrienes; D001094:Arachidonate 5-Lipoxygenase; D001241:Aspirin
keywords: Aspirin-exacerbated respiratory disease; Chronic rhinosinusitis; Nasal polyposis; Sinus surgery