title: Debridement in chronic osteomyelitis with benign osteopetrosis: A case report.
abstract: Osteopetrosis is a rare bone disease caused by metabolic imbalances as a result of genetic mutations. For instance, autosomal dominant osteopetrosis is caused by a missense mutation of the C1CN7 gene. This was first reported in 1904 and is thought to be caused by osteoclastic dysfunction and an impaired bone resorption ability. An accumulation of cortical bone mass during the remodeling of the medullary bone may increase the bone density and give rise to a hard marble consistency. Osteopetrosis can be divided into benign and malignant forms; however, no curative treatment exists for benign osteopetrosis. The management of complications, such as chronic osteomyelitis and fractures, serves a key role in influencing the patient survival rates. Previous studies have demonstrated that a combined treatment of hyperbaric oxygen (HBO) lavage for debridement of the necrotic region and high-dose systemic antibiotics may be effective in the management of osteopetrosis. The present study reported a case of chronic mandible osteomyelitis and fistula occurring in association with maxillary sinusitis, who was successfully treated by through nasal endoscopy, using repeated flushing and cleaning every 2 weeks as a form of debridement, in the absence of high-dose antibiotics and HBO.
authors.affiliation: Department of Endocrinology and Metabolism, Xiamen Chang Gung Hospital, Xiamen, Fujian 361000, P.R. China.
authors.forename: Yu-Ping
authors.initials: YP
authors.lastname: Liu
authors.affiliation: Department of Hematology, Xiamen Chang Gung Hospital, Xiamen, Fujian 361000, P.R. China.
authors.forename: Xiang-Hua
authors.initials: XH
authors.lastname: Lin
authors.affiliation: Department of Otorhinolaryngology, Xiamen Chang Gung Hospital, Xiamen, Fujian 361000, P.R. China.
authors.forename: Man-Yun
authors.initials: MY
authors.lastname: Yan
authors.affiliation: Department of Otorhinolaryngology, Xiamen Chang Gung Hospital, Xiamen, Fujian 361000, P.R. China.
authors.forename: Bao-Quan
authors.initials: BQ
authors.lastname: Lin
authors.affiliation: Department of Otorhinolaryngology, Xiamen Chang Gung Hospital, Xiamen, Fujian 361000, P.R. China.
authors.forename: Ming-Ying
authors.initials: MY
authors.lastname: Zhuo
keywords: benign osteopetrosis; chronic osteomyelitis; debridement