title: PIXE study on the effects of parathyroid hormone on elemental content in rat bones.
abstract: Parathyroid hormone (PTH) has attracted considerable interest as a bone anabolic agent. PTH plays a central role in regulating calcium phosphate metabolism and its increases in production in response to low serum calcium levels. A continuous hypersecretion of PTH, as occurs in primary hyperparathyroidism, leads to bone resorption. In this study, the effect of different doses of parathyroid hormone (PTH) on bone mineral content (BMC) in rats was investigated by particle-induced X-ray emission (PIXE). This study will help in investigating further the toxicity of extremely high doses of PTH on BMC. For this study, PTH at doses of 15, 45, or 135μg/kg/day were applied to 9-month-old male and female Sprague Dawley (SD) rats. The concentrations of calcium (Ca), phosphorus (P), strontium (Sr), and zinc (Zn) were measured for bone treatment of PTH. From the results of the research, it was revealed that the biomechanical characteristics of the bone as well as the bone mass were enhanced after the treatment. It was further found that the concentrations of other elements also increased, excluding Zn. This research proved that PTH assists in the treatment of osteoporosis as revealed by the characteristics of different elements. PIXE can be used to determine the concentrations of bone mineral content.
authors.affiliation: Physics Department, College of Science, Sudan University of Science and Technology, Khartoum 11113, Sudan; Physics Department, College of Science, Al Imam Mohammad Ibn Saud Islamic University, Riyadh 11432, Saudi Arabia. Electronic address: mheisas@hotmail.com.
authors.forename: M H
authors.initials: MH
authors.lastname: Eisa
authors.affiliation: Department of Nuclear Science and Technology, Fudan University, Shanghai 200433, PR China.
authors.forename: H
authors.initials: H
authors.lastname: Shen
authors.affiliation: Institute of Radiation Medicine, Fudan University, Shanghai 200032, PR China.
authors.forename: W
authors.initials: W
authors.lastname: Jin
authors.affiliation: Physics Department, College of Science, Al Imam Mohammad Ibn Saud Islamic University, Riyadh 11432, Saudi Arabia; Committee on Radiation and Environmental Pollution Protection, Physics Department, College of Science Al Imam Mohammad Ibn Saud Islamic University, Riyadh 11432, Saudi Arabia.
authors.forename: Abdulaziz S
authors.initials: AS
authors.lastname: Alaamer
authors.affiliation: Physics Department, College of Science, Al Imam Mohammad Ibn Saud Islamic University, Riyadh 11432, Saudi Arabia; Committee on Radiation and Environmental Pollution Protection, Physics Department, College of Science Al Imam Mohammad Ibn Saud Islamic University, Riyadh 11432, Saudi Arabia.
authors.forename: M A
authors.initials: MA
authors.lastname: Al-Rajhi
authors.affiliation: Committee on Radiation and Environmental Pollution Protection, Physics Department, College of Science Al Imam Mohammad Ibn Saud Islamic University, Riyadh 11432, Saudi Arabia; Sudan Atomic Energy Commission, Sudan.
authors.forename: Hajo
authors.initials: H
authors.lastname: Idriss
mesh_terms: D000818:Animals; D015519:Bone Density / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D005269:Femur / Q000187:drug effects* / Q000378:metabolism* / Q000502:physiology; D008297:Male; D010281:Parathyroid Hormone / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013052:Spectrometry, X-Ray Emission
chemical_list: D010281:Parathyroid Hormone
keywords: Element content; Osteoporosis; Parathyroid hormone; Particle induced X-ray emission; Rat bone