title: Hepatitis B Virus Infections and Associated Factors among Pregnant Women Attending Antenatal Care Clinic at Deder Hospital, Eastern Ethiopia.
abstract: BACKGROUND
  Hepatitis B virus (HBV) infection is a serious public health problem worldwide. Reports have shown that 68,600 people die of HBV infection and more than 300,000 deaths due to liver cancer secondary to hepatitis B every year globally. Women who are infected with HBV can vertically transmit the infection to their infants. This study aims to determine the prevalence of HBV infection and associated factors among pregnant women.
  
  
  RESULTS
  A hospital-based cross-sectional study was conducted among pregnant women who attended antenatal care clinic (ANC) for routine pregnancy check-up between 18 March 2015 and 15 May 2015. Data were collected by face to face interview using a pre-tested questionnaire. Serum was withdrawn for each study subject and used to test for Hepatitis B Surface Antigen (HBsAg) by an enzyme linked immunosorbent assay (ELISA) test kit. Binary logistic regression analysis was used to examine the association between explanatory variables and outcome variable. The prevalence of HBV infection was found to be 6.9%. Interestingly, the history of abortion (AOR 10.9; 95% CI: 2.2-53.9), nose piercing (AOR 9.1; 95% CI: 1.34-61.79), surgical procedure (AOR 12.8; 95% CI: 1.68-97.06) and history of multiple sexual partners (AOR 16.8; 95% CI: 3.18-89.06) were significant predictors of HBV infection.
  
  
  CONCLUSIONS
  This study determined that the prevalence of HBV infection among pregnant women was 6.9%, implying that it is high-intermediate endemic area, which is important public health issue needs to be addressed. History of abortion, nose piercing, surgical procedures and multiple sexual partners were significantly associated with this viral infection. Accordingly we advocate that health education programs on the mode of HBV transmission, high-risk behaviors and methods of preventions should be instituted at antenatal care clinics to raise the awareness of mothers and limit the spread of infection. It is also advisable to implement nosocomial infection prevention strategies to prevent the transmissions of HBV through health care related activities such as surgical procedures. Furthermore, all pregnant women should be screened for HBV, treated if necessary to reduce their viral loads and their children vaccinated at birth with the single-dose hepatitis B vaccine to break the cycle of mother-to-child transmission.
authors.affiliation: Department of Medical Laboratory, Deder Hospital, Deder, Ethiopia.
authors.forename: Abdi
authors.initials: A
authors.lastname: Umare
authors.affiliation: Department of Microbiology Sciences, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia.
authors.forename: Berhanu
authors.initials: B
authors.lastname: Seyoum
authors.affiliation: Department of Public Health, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia.
authors.forename: Tesfaye
authors.initials: T
authors.lastname: Gobena
authors.affiliation: Ethiopian Red Cross Society Blood Bank, Harar Branch, Ethiopia.
authors.forename: Tamirat
authors.initials: T
authors.lastname: Haile Mariyam
mesh_terms: D000028:Abortion, Induced / Q000009:adverse effects*; D000293:Adolescent; D000328:Adult; D046288:Body Piercing / Q000009:adverse effects*; D003430:Cross-Sectional Studies; D005002:Ethiopia / Q000453:epidemiology; D005260:Female; D006509:Hepatitis B / Q000150:complications / Q000453:epidemiology*; D006514:Hepatitis B Surface Antigens / Q000097:blood; D006515:Hepatitis B virus / Q000472:pathogenicity*; D006801:Humans; D009666:Nose / Q000293:injuries; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000453:epidemiology* / Q000821:virology; D011295:Prenatal Care; D015995:Prevalence; D012307:Risk Factors; D011795:Surveys and Questionnaires; D019562:Viral Load; D055815:Young Adult
chemical_list: D006514:Hepatitis B Surface Antigens