title: Data set ofAspergillus flavusinduced alterations in tear proteome: Understanding the pathogen-induced host response to fungal infection.
abstract: Fungal keratitis is one of the leading causes of blindness in the tropical countries affecting individuals in their most productive age. The host immune response during this infection is poorly understood. We carried out comparative tear proteome analysis ofAspergillus flavuskeratitis patients and uninfected controls. Proteome was separated into glycosylated and non-glycosylated fractions using lectin column chromatography before mass spectrometry. The data revealed the major processes activated in the human host in response to fungal infection and reflected in the tear. Extended analysis of this dataset presented here complements the research article entitled "Aspergillus flavusinduced alterations in tear protein profile reveal pathogen-induced host response to fungal infection [1]" (Jeyalakhsmi Kandhavelu, Naveen Luke Demonte, Venkatesh Prajna Namperumalsamy, Lalitha Prajna, Chitra Thangavel, Jeya Maheshwari Jayapal, Dharmalingam Kuppamuthu, 2016). The mass spectrometry proteomics data have been deposited in the ProteomeXchange Consortium via the PRIDE partner repository with the dataset identifier PRIDE:PXD003825.
authors.affiliation: Department of Proteomics, Aravind Medical Research Foundation, Dr. G. Venkataswamy Eye Research Institute, Aravind Eye Care System, Madurai, Tamil Nadu, India.
authors.forename: Jeyalakshmi
authors.initials: J
authors.lastname: Kandhavelu
authors.affiliation: Department of Proteomics, Aravind Medical Research Foundation, Dr. G. Venkataswamy Eye Research Institute, Aravind Eye Care System, Madurai, Tamil Nadu, India.
authors.forename: Naveen Luke
authors.initials: NL
authors.lastname: Demonte
authors.affiliation: Cornea Clinic, Aravind Eye Hospital, Aravind Eye Care System, Madurai, Tamil Nadu, India.
authors.forename: Venkatesh Prajna
authors.initials: VP
authors.lastname: Namperumalsamy
authors.affiliation: Department of Ocular Microbiology, Aravind Eye Hospital, Aravind Eye Care System, Madurai, Tamil Nadu, India.
authors.forename: Lalitha
authors.initials: L
authors.lastname: Prajna
authors.affiliation: Department of Proteomics, Aravind Medical Research Foundation, Dr. G. Venkataswamy Eye Research Institute, Aravind Eye Care System, Madurai, Tamil Nadu, India.
authors.forename: Chitra
authors.initials: C
authors.lastname: Thangavel
authors.affiliation: Department of Proteomics, Aravind Medical Research Foundation, Dr. G. Venkataswamy Eye Research Institute, Aravind Eye Care System, Madurai, Tamil Nadu, India.
authors.forename: Jeya Maheshwari
authors.initials: JM
authors.lastname: Jayapal
authors.affiliation: Department of Proteomics, Aravind Medical Research Foundation, Dr. G. Venkataswamy Eye Research Institute, Aravind Eye Care System, Madurai, Tamil Nadu, India.
authors.forename: Dharmalingam
authors.initials: D
authors.lastname: Kuppamuthu
keywords: Complement; Glycosylation; Inflammation; Mycotic keratitis; NETosis; Proteomics; Tear; Wound healing