title: Petroleum ether extract ofChenopodium albumL. prevents cell growth and induces apoptosis of human lung cancer cells.
abstract: Chenopodium albumL. is a common edible herb distributed in China that has been used as a traditional Chinese medicine for antiviral, antifungal, anti-inflammatory and cancer treatment. However, to the best of our knowledge no previous reports have investigated its the function of its phytochemical extracts in lung cancer cells. The purpose of the present study was to assess the anticancer activities of the phytochemical extracts ofC. albumL. on human non-small cell lung cancer A549 cells. The present findings demonstrated that the petroleum ether (PE) extract ofC. albumL. exhibited significant growth inhibitory effects on A549 with an IC50value of 33.31±2.79 µg/ml. As determined by MTT and colony formation assays, its growth inhibitory effects were dose- and time-dependent. Furthermore, PE extract-treated A549 cells exhibited dose-dependent cell growth arrest at the G1 phase of the cell cycle and cell apoptosis was induced. These results provide useful data on the anticancer activities ofC. albumL. in human lung cancer and demonstrated the novel possibilities of this plant in developing lung cancer therapies.
authors.affiliation: Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming, Yunnan 650500, P.R. China.
authors.forename: Ting
authors.initials: T
authors.lastname: Zhao
authors.affiliation: Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan 650500, P.R. China.
authors.forename: Hui
authors.initials: H
authors.lastname: Pan
authors.affiliation: Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan 650500, P.R. China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Feng
authors.affiliation: Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan 650500, P.R. China.
authors.forename: Haizhou
authors.initials: H
authors.lastname: Li
authors.affiliation: Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan 650500, P.R. China; Institute of Plant Physiology & Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 20000, P.R. China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhao
keywords: Chenopodium album L.; G1 phase arrest; apoptosis; non-small cell lung cancer cell A549; petroleum ether extract