title: Modern Synthetic Avenues for the Preparation of Functional Fluorophores.
abstract: Biomedical research relies on the fast and accurate profiling of specific biomolecules and cells in a non-invasive manner. Functional fluorophores are powerful tools for such studies. As these sophisticated structures are often difficult to access through conventional synthetic strategies, new chemical processes have been developed in the past few years. In this Minireview, we describe the most recent advances in the design, preparation, and fine-tuning of fluorophores by means of multicomponent reactions, C-H activation processes, cycloadditions, and biomolecule-based chemical transformations.
authors.affiliation: MRC/UoE Centre for Inflammation Research, The University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK.
authors.forename: Fabio
authors.initials: F
authors.lastname: de Moliner
authors.affiliation: Laboratory of Organic Chemistry, Faculty of Pharmacy, University of Barcelona, Barcelona Science Park, Baldiri Reixac 10-12, Barcelona, 08028, Spain.
authors.forename: Nicola
authors.initials: N
authors.lastname: Kielland
authors.affiliation: Laboratory of Organic Chemistry, Faculty of Pharmacy, University of Barcelona, Barcelona Science Park, Baldiri Reixac 10-12, Barcelona, 08028, Spain.|CIBER-BBN, Networking Centre for Bioengineering, Biomaterials and Nanomedicine, Baldiri Reixac 10-12, Barcelona, 08028, Spain.
authors.forename: Rodolfo
authors.identifier: 0000-0002-5006-9917
authors.initials: R
authors.lastname: Lavilla
authors.affiliation: MRC/UoE Centre for Inflammation Research, The University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK.
authors.forename: Marc
authors.identifier: 0000-0002-5392-9740
authors.initials: M
authors.lastname: Vendrell
keywords: C−H activation; fluorescent probes; imaging; microscopy; multicomponent reactions