title: Chitosan nanocomposites based on distinct inorganic fillers for biomedical applications.
abstract: Chitosan (CHI), a biocompatible and biodegradable polysaccharide with the ability to provide a non-protein matrix for tissue growth, is considered to be an ideal material in the biomedical field. However, the lack of good mechanical properties limits its applications. In order to overcome this drawback, CHI has been combined with different polymers and fillers, leading to a variety of chitosan-based nanocomposites. The extensive research on CHI nanocomposites as well as their main biomedical applications are reviewed in this paper. An overview of the different fillers and assembly techniques available to produce CHI nanocomposites is presented. Finally, the properties of such nanocomposites are discussed with particular focus on bone regeneration, drug delivery, wound healing and biosensing applications.
authors.affiliation: 3B's Research Group, Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Guimarães, Portugal; ICVS/3B's, Associate PT Government Laboratory, Braga, Guimarães, Portugal; Institute for Polymers and Composites/I3 N, Department of Polymer Engineering, University of Minho, Guimarães, Portugal.
authors.forename: Duarte
authors.initials: D
authors.lastname: Moura
authors.affiliation: 3B's Research Group, Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Guimarães, Portugal; ICVS/3B's, Associate PT Government Laboratory, Braga, Guimarães, Portugal.
authors.forename: João F
authors.initials: JF
authors.lastname: Mano
authors.affiliation: Institute for Polymers and Composites/I3 N, Department of Polymer Engineering, University of Minho , Guimarães , Portugal.
authors.forename: Maria C
authors.initials: MC
authors.lastname: Paiva
authors.affiliation: 3B's Research Group, Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Guimarães, Portugal; ICVS/3B's, Associate PT Government Laboratory, Braga, Guimarães, Portugal.
authors.forename: Natália M
authors.initials: NM
authors.lastname: Alves
keywords: 101 Self-assembly / Self-organized materials; 102 Porous / Nanoporous / Nanostructured materials; 103 Composites; 104 Carbon and related materials; 20 Organic and soft materials (colloids; 211 Scaffold / Tissue engineering / Drug delivery; 212 Surface and interfaces; 306 Thin film / Coatings; Chitosan; biomedical applications; gel; liquid crystals; polymer nanocomposites; polymers)