title: Impact of Pseudomonas aeruginosa Infection on Respiratory Muscle Function in Adult Cystic Fibrosis Patients.
abstract: BACKGROUND
  Pseudomonas aeruginosa infection impairs respiratory muscle function in adolescents with cystic fibrosis, but its impact on adult patients has not been characterised.
  
  
  OBJECTIVE
  To investigate respiratory muscle function in adult cystic fibrosis patients according to P. aeruginosa status (repetitive samples over 12 months).
  
  
  METHODS
  The pressure-time index of the respiratory muscles (PTImus), a measure of their efficiency, served as the primary outcome. In addition, respiratory load and maximal respiratory muscle strength were assessed.
  
  
  RESULTS
  In 51 patients examined (65% female; median age 32 years, IQR 24-40), a median of 3.0 (IQR 2-4) different pathogens was found in each patient. The PTImus was 0.113 and 0.126 in Pseudomonas-positive (n = 33) and -negative (n = 18) patients, respectively (p = 0.53). Univariate analysis showed a lower PTImus in male than in female patients (p = 0.006). Respiratory muscle load and strength were otherwise comparable, with the exception of higher nasal sniff pressures in Pseudomonas-positive patients who were chronically infected (>50% of positive samples). Quality of Life (according to the Cystic Fibrosis Questionnaire-Revised) was higher if both respiratory load and the PTImus were low (high respiratory muscle efficiency).
  
  
  CONCLUSIONS
  Chronic P. aeruginosa infection does not influence respiratory muscle efficiency in adult cystic fibrosis patients with otherwise multiple co-infections. In addition, patients with reduced respiratory muscle efficiency had worse Quality of Life.
authors.affiliation: Department of Pneumology, Cologne Merheim Hospital, Kliniken der Stadt Köln gGmbH, Faculty of Health/School of Medicine, Witten/Herdecke University, Cologne, Germany.
authors.forename: Friederike Sophie
authors.initials: FS
authors.lastname: Magnet
authors.forename: Jens
authors.initials: J
authors.lastname: Callegari
authors.forename: Doris
authors.initials: D
authors.lastname: Dieninghoff
authors.forename: Marc
authors.initials: M
authors.lastname: Spielmanns
authors.forename: Jan Hendrik
authors.initials: JH
authors.lastname: Storre
authors.forename: Claudia
authors.initials: C
authors.lastname: Schmoor
authors.forename: Wolfram
authors.initials: W
authors.lastname: Windisch
mesh_terms: D000328:Adult; D003550:Cystic Fibrosis / Q000382:microbiology / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D011552:Pseudomonas Infections / Q000503:physiopathology*; D011550:Pseudomonas aeruginosa; D015656:Respiratory Mechanics; D055815:Young Adult