title: Appearance of fetal pain could be associated with maturation of the mesodiencephalic structures.
abstract: Fetal pain remains a controversial subject both in terms of recognizing its existence and the time-frame within which it appears. This article investigates the hypothesis that pain perception during development is not related to any determined structures of the central nervous system (CNS), on the contrary, the process of perception could be made with any structure satisfying conditions that the perception of pain is the organization, identification, and interpretation of sensory information in order to represent and understand the environment. According to this definition, chronic decerebrate and decorticate experimental animals, anencephalic, and hydranencephalic patients demonstrate that the basic, most general, appropriate interaction with the environment can be achieved with a functional mesodiencephalon (brain stem, and diencephalon) as the hierarchically highest structure of the CNS during development. In intact fetuses, this structure shows signs of sufficient maturation starting from the 15th week of gestation. Bearing in mind the dominant role of the reticular formation of the brain stem, which is marked by a wide divergence of afferent information, a sense of pain transmitted through it is diffuse and can dominate the overall perception of the fetus. The threshold for tactile stimuli is lower at earlier stages of gestation. The pain inhibition mechanisms are not sufficiently developed during intrauterine development, which is another factor that leads to increased intensity of pain in the fetus. As a conclusion it could be proposed that the fetus is exposed to rudimentary painful stimuli starting from the 15thgestation week and that it is extremely sensitive to painful stimuli.
authors.affiliation: Department of Neurology, Faculty of Medicine Novi Sad, University of Novi Sad.
authors.forename: Slobodan
authors.initials: S
authors.lastname: Sekulic
authors.affiliation: Department of Neurology, Faculty of Medicine Novi Sad, University of Novi Sad.
authors.forename: Ksenija
authors.initials: K
authors.lastname: Gebauer-Bukurov
authors.affiliation: Department of Neurology, Faculty of Medicine Novi Sad, University of Novi Sad.
authors.forename: Milan
authors.initials: M
authors.lastname: Cvijanovic
authors.affiliation: Department of Neurology, Faculty of Medicine Novi Sad, University of Novi Sad.
authors.forename: Aleksandar
authors.initials: A
authors.lastname: Kopitovic
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine Novi Sad, University of Novi Sad.
authors.forename: Djordje
authors.initials: D
authors.lastname: Ilic
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine Novi Sad, University of Novi Sad.
authors.forename: Djordje
authors.initials: D
authors.lastname: Petrovic
authors.affiliation: Department of Histology and Embryology, Faculty of Medicine Novi Sad, University of Novi Sad.
authors.forename: Ivan
authors.initials: I
authors.lastname: Capo
authors.affiliation: Department of Developmental Neurology and Epilepsy, Institute for Child and Youth Health Care of Vojvodina, Faculty of Medicine Novi Sad, University of Novi Sad, Novi Sad, Serbia.
authors.forename: Ivana
authors.initials: I
authors.lastname: Pericin-Starcevic
authors.affiliation: School of Applied Psychology, Institute Humans in Complex Systems, Olten, Switzerland.
authors.forename: Oliver
authors.initials: O
authors.lastname: Christ
authors.affiliation: Department of Orthopaedics and Traumatology, University Hospital of Heraklion, Faculty of Medicine, University of Crete, Heraklion, Greece.
authors.forename: Anastasia
authors.initials: A
authors.lastname: Topalidou
keywords: brain stem; fetus; pain; perception; thalamus