title: Association between Body Mass Index and Sputum Culture Conversion among South Korean Patients with Multidrug Resistant Tuberculosis in a Tuberculosis Referral Hospital.
abstract: BACKGROUND
  Multidrug-resistant tuberculosis (MDR-TB) is an important global health problem. Furthermore, the time to identify a positive sputum culture is an important risk factor for the spread of tuberculosis, and several factors can predict a prolonged time to culture conversion. Moreover, the relationship between poor nutritional status and infectious disease is clearly established. Therefore, the present study aimed to investigate the association between body mass index (BMI) and sputum culture conversion within 3 months among patients with MDR-TB.
  
  
  METHODS
  We retrospectively evaluated 218 patients with MDR-TB who were treated at a large tuberculosis referral hospital in South Korea between January 2005 and December 2010. The outcome of interest was defined as sputum culture conversion within 3 months, and we analyzed the association between BMI and this outcome.
  
  
  RESULTS
  Among the 218 patients, 53 patients (24.3%) had a low BMI (<18.5 kg/m²). In the multivariate Cox proportional-hazards regression analysis, failure to achieve sputum culture conversion within 3 months was independently associated with having a low BMI (hazard ratio [HR]: 1.741, 95% confidence interval [CI]: 1.006-3.013; P = 0.047) and a positive sputum smear at the initiation of therapy (HR: 8.440, 95% CI: 1.146-62.138, P = 0.036).
  
  
  CONCLUSIONS
  Low BMI (<18.5 kg/m²) was an independent risk factor for failure to achieve sputum culture conversion within 3 months among patients with MDR-TB.
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, College of Medicine and Institute of Health Sciences, Gyeongsang National University Changwon Hospital, Changwon, Korea.
authors.forename: Hyun Oh
authors.identifier: http://orcid.org/0000-0003-1302-6456
authors.initials: HO
authors.lastname: Park
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, College of Medicine and Institute of Health Sciences, Gyeongsang National University Changwon Hospital, Changwon, Korea.
authors.forename: Sung Hwan
authors.initials: SH
authors.lastname: Kim
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, College of Medicine and Institute of Health Sciences, Gyeongsang National University Changwon Hospital, Changwon, Korea.
authors.forename: Seong Ho
authors.initials: SH
authors.lastname: Moon
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, College of Medicine and Institute of Health Sciences, Gyeongsang National University Changwon Hospital, Changwon, Korea.
authors.forename: Joung Hun
authors.initials: JH
authors.lastname: Byun
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, College of Medicine and Institute of Health Sciences, Gyeongsang National University Changwon Hospital, Changwon, Korea.
authors.forename: Jong Woo
authors.initials: JW
authors.lastname: Kim
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, College of Medicine and Institute of Health Sciences, Gyeongsang National University Hospital, Jinju, Korea.
authors.forename: Chung Eun
authors.initials: CE
authors.lastname: Lee
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, College of Medicine and Institute of Health Sciences, Gyeongsang National University Hospital, Jinju, Korea.
authors.forename: Jong Duk
authors.initials: JD
authors.lastname: Kim
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, College of Medicine and Institute of Health Sciences, Gyeongsang National University Hospital, Jinju, Korea.
authors.forename: In Seok
authors.initials: IS
authors.lastname: Jang
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, College of Medicine and Institute of Health Sciences, Gyeongsang National University Hospital, Jinju, Korea. junhoyah@hanmail.net.
authors.forename: Jun Ho
authors.identifier: http://orcid.org/0000-0002-7508-5307
authors.initials: JH
authors.lastname: Yang
keywords: Multidrug-resistant; Nutritional status; Risk factors; Sputum; Tuberculosis