title: Identification of novel SNPs associated with risk and prognosis in patients with castration-resistant prostate cancer.
abstract: OBJECTIVE
  Metabolism and transport play major roles in life-long exposure to endogenous and exogenous carcinogens. We therefore explored associations between polymorphisms in absorption, distribution, metabolism and elimination genes and the risk and prognosis of castration-resistant prostate cancer (CRPC).
  
  
  METHODS
  A total of 634 genotypes were tested in 74 patients using the Affymetrix DMETv1.0 platform.
  
  
  RESULTS
  No relation to risk was found. Three SNPs were associated with CRPC prognosis in Caucasians: ABCB11 rs7602171G>A (p = 0.003; n = 30; hazard ratio [HR]: 0.307), GSTP1 rs1799811C>T (p = 0.001; n = 38; HR: 0.254) and SLC5A6 rs1395 (p = 0.004; n = 35; HR: 3.15). Two other polymorphisms among Caucasians were associated with interesting trends: ABCB4 rs2302387C>T (p = 0.039) and ABCC5 rs939339A>G (p = 0.018).
  
  
  CONCLUSIONS
  This exploratory study is the first to show that polymorphisms in several absorption, distribution, metabolism and elimination genes may be associated with CRPC prognosis.
authors.affiliation: Clinical Pharmacology Program, Office of the Clinical Director, National Cancer Institute, 9000 Rockville Pike, Building 10, Room 5A01, Bethesda, MD 20892, USA.
authors.forename: Tristan M
authors.initials: TM
authors.lastname: Sissung
authors.affiliation: Inova Comprehensive Cancer & Research Institute, Falls Church, VA 22042, USA.
authors.forename: John
authors.initials: J
authors.lastname: Deeken
authors.affiliation: Clinical Pharmacology Program, Office of the Clinical Director, National Cancer Institute, 9000 Rockville Pike, Building 10, Room 5A01, Bethesda, MD 20892, USA.
authors.forename: Crystal R
authors.initials: CR
authors.lastname: Leibrand
authors.affiliation: Molecular Pharmacology Program, National Cancer Institute, 9000 Rockville Pike, Building 10, Room 5A01, Bethesda, MD 20892, USA.
authors.forename: Douglas K
authors.initials: DK
authors.lastname: Price
authors.affiliation: Molecular Pharmacology Program, National Cancer Institute, 9000 Rockville Pike, Building 10, Room 5A01, Bethesda, MD 20892, USA.
authors.forename: Sheryl
authors.initials: S
authors.lastname: Ehrlich
authors.affiliation: Biostatistics & Data Management Section, Office of the Clinical Director, National Cancer Institute, NIH, Shady Grove, MD 20850, USA.
authors.forename: Seth M
authors.initials: SM
authors.lastname: Steinberg
authors.affiliation: Biostatistics & Data Management Section, Office of the Clinical Director, National Cancer Institute, NIH, Shady Grove, MD 20850, USA.
authors.forename: David J
authors.initials: DJ
authors.lastname: Liewehr
authors.affiliation: Prostate Cancer Clinical Research Section, Genitourinary Malignancies Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
authors.forename: William
authors.initials: W
authors.lastname: Dahut
authors.affiliation: Clinical Pharmacology Program, Office of the Clinical Director, National Cancer Institute, 9000 Rockville Pike, Building 10, Room 5A01, Bethesda, MD 20892, USA.|Molecular Pharmacology Program, National Cancer Institute, 9000 Rockville Pike, Building 10, Room 5A01, Bethesda, MD 20892, USA.
authors.forename: William D
authors.initials: WD
authors.lastname: Figg
mesh_terms: D000074020:ATP Binding Cassette Transporter, Subfamily B, Member 11; D018528:ATP-Binding Cassette Transporters / Q000235:genetics; D000328:Adult; D000368:Aged; D005838:Genotype; D051549:Glutathione S-Transferase pi / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D064129:Prostatic Neoplasms, Castration-Resistant / Q000209:etiology / Q000235:genetics* / Q000401:mortality; D012306:Risk; D027981:Symporters / Q000235:genetics
chemical_list: C093491:ABCB11 protein, human; D000074020:ATP Binding Cassette Transporter, Subfamily B, Member 11; D018528:ATP-Binding Cassette Transporters; D027981:Symporters; C119981:biotin transporter; C496556:GSTP1 protein, human; D051549:Glutathione S-Transferase pi
keywords: castration-resistant prostate cancer; genotype; metabolism; outcome; survival; transport