title: LMO2 promotes tumor cell invasion and metastasis in basal-type breast cancer by altering actin cytoskeleton remodeling.
abstract: LMO2 is traditionally recognized as a pivotal transcriptional regulator during embryonic hematopoiesis and angionenesis, and its ectopic expression in T lymphocyte progenitors is closely correlated to the onset of acute T lymphocytic leukemia. However, recently studies revealed complicated expression features and dual functions of LMO2 on tumor behaviors in a variety of cancer types, including breast cancers. Basal-type breast cancer is one of the breast cancer subtypes and a prognostically unfavorable subtype among all breast cancers. Herein we found that in basal-type breast cancer specifically, high LMO2 expression was positively correlated with lymph node metastases in patients, promoted tumor cell migration and invasion and increased distant metastasis in SCID mice. Moreover, the novel function of LMO2 was achieved by its predominantly cytoplasmic location and interaction with cofilin1, which is a critical regulator in actin cytoskeleton dynamics. These findings suggest a subtype-dependent role of LMO2 in breast cancers and the potential of LMO2 as a subtype-specific biomarker for clinical practice.
authors.affiliation: Laboratory of Molecular Genetics in School of Medicine, Nankai University, Tianjin, China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Laboratory of Molecular Genetics in School of Medicine, Nankai University, Tianjin, China.
authors.forename: Zhaoyang
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Laboratory of Molecular Genetics in School of Medicine, Nankai University, Tianjin, China.
authors.forename: Di
authors.initials: D
authors.lastname: Huang
authors.affiliation: Laboratory of Molecular Genetics in School of Medicine, Nankai University, Tianjin, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Wu
authors.affiliation: Laboratory of Molecular Genetics in School of Medicine, Nankai University, Tianjin, China.
authors.forename: Huihui
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Histology and Embryology in School of Medicine, Nankai University, Tianjin, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Pathology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Meng
authors.affiliation: Laboratory of Stem cells in School of Medicine, Nankai University, Tianjin, China.
authors.forename: Zongjin
authors.initials: Z
authors.lastname: Li
authors.affiliation: Laboratory of Molecular Genetics in School of Medicine, Nankai University, Tianjin, China.
authors.forename: Tianhui
authors.initials: T
authors.lastname: Zhu
authors.affiliation: Laboratory of Molecular Genetics in School of Medicine, Nankai University, Tianjin, China.
authors.forename: Shuang
authors.initials: S
authors.lastname: Yang
authors.affiliation: Laboratory of Molecular Genetics in School of Medicine, Nankai University, Tianjin, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Sun
mesh_terms: D008841:Actin Cytoskeleton / Q000378:metabolism* / Q000473:pathology; D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D001943:Breast Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D002465:Cell Movement; D051338:Cofilin 1 / Q000235:genetics / Q000378:metabolism; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D060588:LIM Domain Proteins / Q000235:genetics / Q000378:metabolism*; D054461:Lim Kinases / Q000235:genetics / Q000378:metabolism; D008207:Lymphatic Metastasis; D061986:MCF-7 Cells; D008807:Mice, Inbred BALB C; D016513:Mice, SCID; D009361:Neoplasm Invasiveness; D010766:Phosphorylation; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D022502:Stress Fibers / Q000378:metabolism / Q000473:pathology
chemical_list: D048868:Adaptor Proteins, Signal Transducing; C495810:CFL1 protein, human; D051338:Cofilin 1; D060588:LIM Domain Proteins; C085117:LMO2 protein, human; D011518:Proto-Oncogene Proteins; C515892:LIMK1 protein, human; D054461:Lim Kinases
keywords: LMO2; actin filament; basal-type breast cancer; cofilin1; metastasis