title: Seroprevalence of cutaneous human papillomaviruses (HPVs) among men in the multinational HPV Infection in Men study.
abstract: Data on cutaneous human papillomavirus (HPV) seroprevalence are primarily derived from skin cancer case-control studies. Few studies have reported the seroprevalence of cutaneous HPV among healthy men. This study investigated the seroprevalence of cutaneous HPV types and associated risk factors among men residing in Brazil, Mexico and the USA. Six hundred men were randomly selected from the HPV Infection in Men study. Archived serum specimens were tested for antibodies against 14 cutaneous HPV genotypes, β-HPV types (5/8/12/14/17/22/23/24/38/48), α-HPV 27, γ-HPV 4, µ-HPV1 and ν-HPV 41 using a glutathione S-transferase L1-based multiplex serology assay. Risk factor data were collected by a questionnaire. Binomial proportions were used to estimate seroprevalence, and logistic regression to examine factors associated with seropositivity. Overall, 65.4 % of men were seropositive to ≥1 of the 14 cutaneous HPV types, and 39.0 % were positive for ≥1 β-HPV types. Seroprevalence was 8.9, 30.9, 28.6 and 9.4 % for α-HPV 27, γ-HPV 4, µ-HPV 1 and ν-HPV 41, respectively. In multivariate analyses, seropositivity for any cutaneous HPV type was associated with higher education [adjusted odds ratio (AOR) 1.75; 95 % confidence interval (CI) 1.08-2.83], and seropositivity of any β-HPV type was significantly associated with increasing age (AOR 1.72; 95 % CI 1.12-2.63, for men aged 31-44 years vs men aged 18-30 years). Other factors associated with various type-specific cutaneous HPV seropositivity included country, circumcision and lifetime number of male sexual partners. These data indicate that exposure to cutaneous HPV is common. Future studies are needed to assess the role of cutaneous HPV in diseases.
authors.affiliation: Department of Cancer Epidemiology, Center for Infection Research in Cancer, Moffitt Cancer Center, Tampa, FL, USA.|Department of Epidemiology and Biostatistics, College of Public Health, University of South Florida, Tampa, FL, USA.
authors.forename: Shams
authors.initials: S
authors.lastname: Rahman
authors.affiliation: Department of Cancer Epidemiology, Center for Infection Research in Cancer, Moffitt Cancer Center, Tampa, FL, USA.
authors.forename: Christine M
authors.initials: CM
authors.lastname: Pierce Campbell
authors.affiliation: Molecular Diagnostics of Oncogenic Infections Division, Infection, Inflammation and Cancer Research Program, German Cancer Research Center (DKFZ), Heidelberg, Germany.
authors.forename: Tim
authors.initials: T
authors.lastname: Waterboer
authors.affiliation: Department of Cancer Epidemiology, Center for Infection Research in Cancer, Moffitt Cancer Center, Tampa, FL, USA.
authors.forename: Dana E
authors.initials: DE
authors.lastname: Rollison
authors.affiliation: Vanderbilt Institute for Global Health, Nashville, TN, USA.
authors.forename: Donna J
authors.initials: DJ
authors.lastname: Ingles
authors.affiliation: Department of Biostatistics, Center for Infection Research in Cancer, Moffitt Cancer Center, Tampa, FL, USA.
authors.forename: B Nelson
authors.initials: BN
authors.lastname: Torres
authors.affiliation: Molecular Diagnostics of Oncogenic Infections Division, Infection, Inflammation and Cancer Research Program, German Cancer Research Center (DKFZ), Heidelberg, Germany.
authors.forename: Angelika
authors.initials: A
authors.lastname: Michel
authors.affiliation: Department of Cancer Epidemiology, Center for Infection Research in Cancer, Moffitt Cancer Center, Tampa, FL, USA.
authors.forename: Staci L
authors.initials: SL
authors.lastname: Sudenga
authors.affiliation: Molecular Diagnostics of Oncogenic Infections Division, Infection, Inflammation and Cancer Research Program, German Cancer Research Center (DKFZ), Heidelberg, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Pawlita
authors.affiliation: School of Medicine, Universidade de São Paulo, São Paulo, Brazil.
authors.forename: Luisa L
authors.initials: LL
authors.lastname: Villa
authors.affiliation: Instituto Nacional de Salud Pública, Cuernavaca, Mexico.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Lazcano Ponce
authors.affiliation: Department of Epidemiology and Biostatistics, College of Public Health, University of South Florida, Tampa, FL, USA.
authors.forename: Amy R
authors.initials: AR
authors.lastname: Borenstein
authors.affiliation: Department of Epidemiology and Biostatistics, College of Public Health, University of South Florida, Tampa, FL, USA.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.affiliation: Department of Cancer Epidemiology, Center for Infection Research in Cancer, Moffitt Cancer Center, Tampa, FL, USA.
authors.forename: Anna R
authors.initials: AR
authors.lastname: Giuliano
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000097:blood; D001938:Brazil / Q000453:epidemiology; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D027383:Papillomaviridae / Q000145:classification / Q000235:genetics / Q000276:immunology* / Q000302:isolation & purification; D030361:Papillomavirus Infections / Q000097:blood* / Q000276:immunology / Q000821:virology; D011446:Prospective Studies; D016036:Seroepidemiologic Studies; D012871:Skin Diseases / Q000097:blood / Q000821:virology*; D055815:Young Adult
chemical_list: D000914:Antibodies, Viral