title: Global Deformation Parameters Response to Exercise in Adolescents with Repaired Tetralogy of Fallot.
abstract: Exercise stress echocardiography is rarely used in the follow-up of children with congenital heart disease following surgical repair. There are no data on global longitudinal strain (GLS) and global circumferential strain (GCS) during exercise in adolescents with repaired tetralogy of Fallot (TOF). The purpose of this prospective study was to investigate GLS and GCS using speckle tracking two-dimensional echocardiography (2D-STE) at rest and during exercise in adolescents with repaired TOF. Twenty patients with repaired TOF and 20 controls were included. The subjects exercised on a semi-supine cycle ergometer using a two-staged 3-min step protocol of 20-40 W at 60-75 rpm. Exercise images with 2D-STE measurements were available for all 40 subjects. In the study group, the GLS values changed significantly between the baseline and third and sixth minute of exercise (-18.10 ± 2.20, -16.23 ± 4.47, -14.22 ± 2.63, respectively, p < 001). GCS did not vary significantly from baseline to end of the exercise testing (-17.49 ± 5.14, -17.15 ± 9.20, -15.66 ± 3.59, respectively, p > 0.05). There was a statistically significant difference between the Stage I longitudinal strain values of the study and control groups (-14.26 ± 9.13 and -20.22 ± 2.88, respectively, p = 0.02) but no significant difference between the Stage II values of these groups (-14.22 ± 2.63 and -15.11 ± 2.45, respectively, p > 0.05). The results revealed significant changes in GLS during exercise in patients with repaired TOF. Data gathered from deformation analysis of 2D-STE during exercise testing can enhance the ability to detect subtle ventricular dysfunction in the follow-up of children with repaired TOF.
authors.affiliation: Department of Pediatric Cardiology, Izmir Dr. Behcet Uz Children's Hospital, 1374 Street Alsancak, 35320, Izmir, Turkey.
authors.forename: Timur
authors.initials: T
authors.lastname: Mese
authors.affiliation: Department of Pediatric Cardiology, Izmir Dr. Behcet Uz Children's Hospital, 1374 Street Alsancak, 35320, Izmir, Turkey. drbarisguven@yahoo.com.
authors.forename: Baris
authors.initials: B
authors.lastname: Guven
authors.affiliation: Department of Pediatric Cardiology, Izmir Dr. Behcet Uz Children's Hospital, 1374 Street Alsancak, 35320, Izmir, Turkey.
authors.forename: Murat Muhtar
authors.initials: MM
authors.lastname: Yilmazer
authors.affiliation: Department of Pediatric Cardiology, Izmir Dr. Behcet Uz Children's Hospital, 1374 Street Alsancak, 35320, Izmir, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Demirol
authors.affiliation: Department of Pediatric Cardiology, Izmir Dr. Behcet Uz Children's Hospital, 1374 Street Alsancak, 35320, Izmir, Turkey.
authors.forename: Şenay
authors.initials: Ş
authors.lastname: Çoban
authors.affiliation: Department of Pediatric Cardiology, Izmir Katip Celebi University Medical Faculty, Izmir, Turkey.
authors.forename: Cem
authors.initials: C
authors.lastname: Karadeniz
mesh_terms: D000293:Adolescent; D004452:Echocardiography; D005080:Exercise Test; D005260:Female; D006801:Humans; D008297:Male; D010372:Pediatrics; D011446:Prospective Studies; D013771:Tetralogy of Fallot / Q000601:surgery*; D014421:Turkey; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging*
keywords: Pediatric cardiology; Strain; Stress echocardiography; Tetralogy of Fallot