title: Anti-Heat Shock Protein-27 Antibody Levels in Women with Breast Cancer: Association with Disease Complications and Two-Year Disease-Free Survival
abstract: Background and Aim: Breast cancer is a major healthcare problem in women. There are many reports about
  up-regulation of Hsp27 in cancer tissues but less is known about the potential relationship between Hsp27 antibody
  levels and breast cancer complications. We here investigated concentrations of serum Hsp27 antigen and antibodies
  in subjects with and without breast cancer and assessed potential associations with two-year disease-free survival,
  histological grade and number of lymph nodes. Materials and Methods: Specifically, serum Hsp27 antigen and antibody
  levels from 97 patients with breast cancer, and 65 healthy controls were determined by enzyme-linkedimmunosorbent
  assays (ELISAs). Results: Serum Hsp27 and antibody levels were significantly (p<0.001) higher in patients with breast
  cancer compared to the control group, but no relationship were found with two-year disease free survival, histological
  grade or number of lymph nodes (p> 0.6, 0.2 and 0.9 respectively). Conclusions: Elevated levels of Hsp27 antibody
  occur in patients with women with breast cancer but do not appear to be associated with the presence of disease clinical
  complications.
authors.affiliation: Cancer Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Email: GhayourM@mums.ac.ir
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Homaei-Shandiz
authors.forename: Hassan
authors.initials: H
authors.lastname: Mehrad-Majd
authors.forename: Mojtaba
authors.initials: M
authors.lastname: Tasbandi
authors.forename: Amir
authors.initials: A
authors.lastname: Aledavood
authors.forename: Jalil
authors.initials: J
authors.lastname: Tavakol Afshari
authors.forename: Vahid
authors.initials: V
authors.lastname: Ghavami
authors.forename: Majid
authors.initials: M
authors.lastname: Ghayour-Mobarhan
keywords: Breast neoplasms; anti; Hsp27 antibody; disease; free survival