title: Antitumor Effects of Sorbus aucuparia L. Extract Highly Saturated with Anthocyans and Their Mechanisms.
abstract: The effects of Fructus Sorbi aucupariae extract, originally saturated with anthocyans, on the development of Lewis lung carcinoma and B-16 melanoma in C57Bl/6 mice and the efficiency of cyclophosphamide treatment were studied. Antitumor activity of the extract and potentiation of the antimetastatic activity of the cytostatic were demonstrated. Studies on melanoma B-16 model revealed an increase in the counts of stromal progenitor cells in the tumor node and their accelerated maturation after treatment with the extract. No effects towards the tumor stem and committed cells were detected.
authors.affiliation: E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia. razinatg22@gmail.com.
authors.forename: T G
authors.initials: TG
authors.lastname: Razina
authors.affiliation: E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
authors.forename: E P
authors.initials: EP
authors.lastname: Zueva
authors.affiliation: E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Ulrich
authors.affiliation: E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.|National Research Tomsk State University, Tomsk, Russia.
authors.forename: O Yu
authors.initials: OY
authors.lastname: Rybalkina
authors.affiliation: E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Chaikovskii
authors.affiliation: Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia.
authors.forename: N V
authors.initials: NV
authors.lastname: Isaikina
authors.affiliation: Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia.
authors.forename: G I
authors.initials: GI
authors.lastname: Kalinkina
authors.affiliation: E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
authors.forename: V V
authors.initials: VV
authors.lastname: Zhdanov
authors.affiliation: E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.|National Research Tomsk State University, Tomsk, Russia.
authors.forename: G N
authors.initials: GN
authors.lastname: Zyuz'kov
mesh_terms: D000818:Animals; D000872:Anthocyanins / Q000494:pharmacology*; D018906:Antineoplastic Agents, Alkylating / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology*; D018827:Carcinoma, Lewis Lung / Q000188:drug therapy* / Q000473:pathology; D003520:Cyclophosphamide / Q000494:pharmacology*; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005260:Female; D005638:Fruit / Q000737:chemistry; D007273:Injections, Intramuscular; D008207:Lymphatic Metastasis; D008546:Melanoma, Experimental / Q000188:drug therapy* / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D009368:Neoplasm Transplantation; D014411:Neoplastic Stem Cells / Q000187:drug effects / Q000473:pathology; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D031994:Sorbus / Q000737:chemistry; D047368:Tumor Burden / Q000187:drug effects; D014407:Tumor Cells, Cultured
chemical_list: D000872:Anthocyanins; D018906:Antineoplastic Agents, Alkylating; D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D003520:Cyclophosphamide
keywords: B-16 melanoma; Fructus Sorbi aucupariae; Lewis lung carcinoma; anthocyans; tumor stem cells