title: Severe thrombocytopenia in a child with typhoid fever: a case report.
abstract: BACKGROUND
  Although thrombocytopenia is common in typhoid fever, its course, response to treatment, and need for specific therapies such as platelet transfusion are not well characterized.
  
  
  METHODS
  We report a case of typhoid fever in a 4-year-old Asian male returned traveler, admitted with prolonged fever and found to have severe thrombocytopenia (platelets 16 × 109/L). Despite appropriate antibiotic therapy, his platelet recovery was slow, but did not lead to complications and he did not require platelet transfusion.
  
  
  CONCLUSIONS
  There is no consensus in the medical literature guiding the optimal management of severe thrombocytopenia in typhoid fever, but it may improve with conservative management, as in our case. The epidemiology and management of this condition merits further research to guide clinical practice.
authors.affiliation: Sydney Children's Hospital, Sydney, Australia. alreesimohammed@gmail.com.|Department of Immunology and Infectious Diseases, Sydney Children's Hospital, High Street, Randwick, NSW, 2031, Australia. alreesimohammed@gmail.com.
authors.forename: Mohammed
authors.initials: M
authors.lastname: Al Reesi
authors.affiliation: Sydney Children's Hospital, Sydney, Australia.
authors.forename: Glenn
authors.initials: G
authors.lastname: Stephens
authors.affiliation: Sydney Children's Hospital, Sydney, Australia.
authors.forename: Brendan
authors.initials: B
authors.lastname: McMullan
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002675:Child, Preschool; D006801:Humans; D008297:Male; D013921:Thrombocytopenia / Q000150:complications* / Q000188:drug therapy; D014435:Typhoid Fever / Q000150:complications* / Q000188:drug therapy
chemical_list: D000900:Anti-Bacterial Agents
keywords: Case report; Prolonged fever; Thrombocytopenia; Typhoid fever