title: Study of dienogest for dysmenorrhea and pelvic pain associated with endometriosis.
abstract: OBJECTIVE
  To evaluate the effect of orally administered dienogest (DNG) for dysmenorrhea and pelvic pain associated with endometriosis.
  
  
  METHODS
  For this study we recruited 89 patients with dysmenorrhea and pelvic pain associated with endometriosis diagnosed by laparoscopy. All patients complained of persistent dysmenorrhea and pelvic pain despite surgical treatment 6 months previously. After 6 months of DNG treatment, we used a 0 to 3 point verbal rating scale to measure the severity of disability in daily life due to dysmenorrhea and pelvic pain, and the use of analgesics. Weight gain, serum lipid and liver enzyme tests were performed before treatment and after 6 months of DNG treatment.
  
  
  RESULTS
  Total dysmenorrhea scores assessed by the verbal rating scale significantly decreased by the end of treatment (P<0.001). The mean (±standard deviation) pain score for dysmenorrhea before and after treatment were 1.42±1.1 and 0.1±0.3, respectively. The mean non-menstrual pelvic pain scores before and after treatment were 0.52±0.6 and 0.18±0.3, respectively, showing a significant difference (P<0.001). The use of analgesics significantly decreased by the end of the treatment (P<0.001). The associated adverse effects were weight gains (in 56 of 89 patients, 63%) and uterine bleeding (in 28 of 89 patients, 31.5%). The weight gain (before treatment, 57.9±9.7; after treatment, 61.1±12.6) was statistically significant (P<0.040).
  
  
  CONCLUSIONS
  This study demonstrated that orally administered DNG could be used to effectively treat dysmenorrhea and pelvic pain associated with endometriosis although the side effects of weight gain and uterine bleeding should be considered.
authors.affiliation: Department of Obstetrics and Gynecology, Chosun University Hospital, Gwangju, Korea.; Department of Obstetrics and Gynecology, Chosun University School of Medicine, Gwangju, Korea.
authors.forename: Soo Ah
authors.initials: SA
authors.lastname: Kim
authors.affiliation: Department of Obstetrics and Gynecology, Chosun University Hospital, Gwangju, Korea.
authors.forename: Mi Jung
authors.initials: MJ
authors.lastname: Um
authors.affiliation: Department of Obstetrics and Gynecology, Chosun University Hospital, Gwangju, Korea.
authors.forename: Han Kyoung
authors.initials: HK
authors.lastname: Kim
authors.affiliation: Department of Obstetrics and Gynecology, Chosun University Hospital, Gwangju, Korea.
authors.forename: Suk Jin
authors.initials: SJ
authors.lastname: Kim
authors.affiliation: Department of Obstetrics and Gynecology, Chosun University Hospital, Gwangju, Korea.
authors.forename: Seo Ju
authors.initials: SJ
authors.lastname: Moon
authors.affiliation: Department of Obstetrics and Gynecology, Chosun University Hospital, Gwangju, Korea.; Department of Obstetrics and Gynecology, Chosun University School of Medicine, Gwangju, Korea.
authors.forename: Hyuk
authors.identifier: 0000-0003-2237-2422
authors.initials: H
authors.lastname: Jung
keywords: Dienogest; Dysmenorrhea; Endometriosis