title: TGF-β Controls the Formation of Kidney-Resident T Cells via Promoting Effector T Cell Extravasation.
abstract: Tissue-resident memory T (TRM) cells, a population of noncirculating memory T cells, are one of the essential components of immunological memory in both mouse and human. Although CD69+CD103+TRMcells represent a major TRMcell population in barrier tissues including the mucosal surface and the skin, CD69+CD103-TRMcells dominate most nonbarrier tissues, such as the kidney. TGF-β is required for the differentiation of CD69+CD103+TRMcells in barrier tissues. However, the developmental control of CD69+CD103-TRMcells in nonbarrier tissues remains largely unknown and the involvement of TGF-β signaling is less clear. In this study we demonstrated that TGF-β promoted the formation of kidney-resident T cells via enhancing the tissue entry of effector T cells. Mechanistically, TGF-β enhanced E- and P-selectin and inflammatory chemokine-mediated extravasation of effector T cells. Thus TGF-β controls the first developmental checkpoint of TRMcell differentiation in nonbarrier tissues.
authors.affiliation: Department of Microbiology, Immunology and Molecular Genetics, School of Medicine, University of Texas Health San Antonio, San Antonio, TX 78229.
authors.forename: Chaoyu
authors.initials: C
authors.lastname: Ma
authors.affiliation: Department of Microbiology, Immunology and Molecular Genetics, School of Medicine, University of Texas Health San Antonio, San Antonio, TX 78229.
authors.forename: Shruti
authors.initials: S
authors.lastname: Mishra
authors.affiliation: Department of Microbiology, Immunology and Molecular Genetics, School of Medicine, University of Texas Health San Antonio, San Antonio, TX 78229.
authors.forename: Erika L
authors.initials: EL
authors.lastname: Demel
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South Univeristy, 87 Xiangya Road, Changsha, Hunan 410008, China.|Department of Microbiology, Immunology and Molecular Genetics, School of Medicine, University of Texas Health San Antonio, San Antonio, TX 78229.
authors.forename: Yong
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Microbiology, Immunology and Molecular Genetics, School of Medicine, University of Texas Health San Antonio, San Antonio, TX 78229.
authors.forename: Nu
authors.initials: N
authors.lastname: Zhang
mesh_terms: D019264:Adoptive Transfer; D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D002454:Cell Differentiation / Q000276:immunology; D005434:Flow Cytometry; D007156:Immunologic Memory / Q000276:immunology*; D007668:Kidney / Q000276:immunology*; D051379:Mice; D008822:Mice, Transgenic; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D016212:Transforming Growth Factor beta / Q000276:immunology*
chemical_list: D016212:Transforming Growth Factor beta