title: Glucocorticoid Receptor Interacting Co-regulators: Putative Candidates for Future Drug Targeting Therapy.
abstract: BACKGROUND
  Glucocorticoids (GCs) are largely used in different inflammatory, autoimmune and proliferative diseases. To date their mechanism of action is not completely clear and more studies are necessary, in particular to explain the great interindividual variability in clinical response. In this panorama the glucocorticoid receptor (GR) has an important role: in fact it regulates the pharmacological response thanks to the capability to interact with different molecules (DNA, RNA, ncRNA and proteins) that are known to influence its activity.
  
  
  RESULTS
  In this review our aim is to highlight the knowledge about the role of protein-protein, RNAprotein interactions and epigenetic modifications on the GR and the consequent response to GCs. The characteristics of these interactions with the GR and their effects on the pharmacological activity of GCs will be examined.
  
  
  CONCLUSIONS
  This information could contribute to the prediction of individual sensitivity to steroids through the identification of new markers of GC resistance. In addition this knowledge may be used in developing new strategies for targeted therapy.
authors.affiliation: PhD School in Science of Reproduction and Development, University of Trieste, Trieste, Italy.
authors.forename: Alessia
authors.initials: A
authors.lastname: Di Silvestre
authors.affiliation: Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.
authors.forename: Marianna
authors.initials: M
authors.lastname: Lucafo
authors.affiliation: Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo', Trieste, Italy.
authors.forename: Sara
authors.initials: S
authors.lastname: De Iudicibus
authors.affiliation: Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Ventura
authors.affiliation: Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo', Trieste, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Martelossi
authors.affiliation: Department of Life Sciences, University of Trieste, Trieste, Italy.
authors.forename: Gabriele
authors.initials: G
authors.lastname: Stocco
authors.affiliation: Department of Life Sciences, University of Trieste, Via Alexander Fleming, 22, 34127 Trieste, Italy.
authors.forename: Giuliana
authors.initials: G
authors.lastname: Decorti
mesh_terms: D000818:Animals; D005938:Glucocorticoids / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D011965:Receptors, Glucocorticoid / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D005938:Glucocorticoids; D011965:Receptors, Glucocorticoid
keywords: Biomarkers; RNA-protein
  interactions; epigenetic; glucocorticoid; glucocorticoid receptor; protein-protein interactions; sensitivity