title: Antihypertensive Treatments in Patients Affected by Aortic Valve Stenosis.
abstract: Systemic hypertension and aortic valve stenosis (AVS) are both age-related diseases. Severe aortic stenosis affects ≈2% to 5% of adults age > 65 years. Systemic hypertension is a frequent comorbidity in patients with AVS and is coexistent for a longer period of time before AVS is treated. Essential systemic hypertension, per se, plays an important role in the creation of lesions on the aortic side of the valve, the region of higher exposure to tension stress. The subsequent endothelial defect represents the principal site of inflammatory process and oxidative stress, leading to aortic sclerosis and calcification. In this review, we want to describe the pharmacological features of the common antihypertensive drugs, analysing the recent literature, in order to achieve useful and updated information about the best treatment of systemic hypertension in patients with concomitant severe aortic stenosis.
authors.affiliation: Laboratory of Biochemical Cardiology Unit for the Study of Aortic, Valvular and Coronary Pathologies Centro Cardiologico Monzino, IRCCS Via Carlo Parea 4, 20138 Milan. Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Poggio
authors.affiliation: Policlinico S. Orsola Malpighi, Univerity of Bologna, Bologna. Italy.
authors.forename: Gianluca
authors.initials: G
authors.lastname: Folesani
authors.affiliation: IRCCSISMETT (Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione), Department for the Treatment and Study of Cardiothoracic Diseases and Cardiothoracic Transplantation, Palermo. Italy.
authors.forename: Giuseppe M
authors.initials: GM
authors.lastname: Raffa
authors.affiliation: University of Milan, Department of Pharmacological and Bimolecular Sciences, Milan. Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Songia
authors.affiliation: Policlinico San Donato IRCCS, San Donato Milanese. Italy.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Valenti
authors.affiliation: Centro Cardiologico Monzino IRCCS, Milan. Italy.
authors.forename: Veronika
authors.initials: V
authors.lastname: Myasoedova
authors.affiliation: Policlinico San Donato IRCCS, Unità Operativa di Cardiochirurgia e Ricerca Traslazionale, San Donato Milanese. Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Parolari
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001024:Aortic Valve Stenosis / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy*
chemical_list: D000959:Antihypertensive Agents
keywords: ACEi/ARB; Hypertension; alpa- beta-blockers; antihypertensive drugs; aortic valve stenosis; calcium channel blockers; diuretics; vasodilators