title: Open Targets: a platform for therapeutic target identification and validation.
abstract: We have designed and developed a data integration and visualization platform that provides evidence about the association of known and potential drug targets with diseases. The platform is designed to support identification and prioritization of biological targets for follow-up. Each drug target is linked to a disease using integrated genome-wide data from a broad range of data sources. The platform provides either a target-centric workflow to identify diseases that may be associated with a specific target, or a disease-centric workflow to identify targets that may be associated with a specific disease. Users can easily transition between these target- and disease-centric workflows. The Open Targets Validation Platform is accessible at https://www.targetvalidation.org.
authors.affiliation: Open Targets, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK gautier.x.koscielny@gsk.com.|GSK, Medicines Research Center, Gunnels Wood Road, Stevenage, SG1 2NY, UK.
authors.forename: Gautier
authors.initials: G
authors.lastname: Koscielny
authors.affiliation: Open Targets, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.|Biogen, Cambridge, MA 02142, USA.
authors.forename: Peter
authors.initials: P
authors.lastname: An
authors.affiliation: Open Targets, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.|European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.
authors.forename: Denise
authors.initials: D
authors.lastname: Carvalho-Silva
authors.affiliation: Open Targets, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.|European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Cham
authors.affiliation: Open Targets, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.|European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.
authors.forename: Luca
authors.initials: L
authors.lastname: Fumis
authors.affiliation: Open Targets, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.|Biogen, Cambridge, MA 02142, USA.
authors.forename: Rippa
authors.initials: R
authors.lastname: Gasparyan
authors.affiliation: Open Targets, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.|GSK, Medicines Research Center, Gunnels Wood Road, Stevenage, SG1 2NY, UK.
authors.forename: Samiul
authors.initials: S
authors.lastname: Hasan
authors.affiliation: Open Targets, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.|European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.
authors.forename: Nikiforos
authors.initials: N
authors.lastname: Karamanis
authors.affiliation: Open Targets, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.|European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.
authors.forename: Michael
authors.initials: M
authors.lastname: Maguire
authors.affiliation: Open Targets, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.|Biogen, Cambridge, MA 02142, USA.
authors.forename: Eliseo
authors.initials: E
authors.lastname: Papa
authors.affiliation: Open Targets, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.|European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.
authors.forename: Andrea
authors.initials: A
authors.lastname: Pierleoni
authors.affiliation: Open Targets, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.|European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.
authors.forename: Miguel
authors.initials: M
authors.lastname: Pignatelli
authors.affiliation: Open Targets, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.|Biogen, Cambridge, MA 02142, USA.
authors.forename: Theo
authors.initials: T
authors.lastname: Platt
authors.affiliation: Open Targets, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.|European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.
authors.forename: Francis
authors.initials: F
authors.lastname: Rowland
authors.affiliation: Open Targets, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.|Biogen, Cambridge, MA 02142, USA.
authors.forename: Priyanka
authors.initials: P
authors.lastname: Wankar
authors.affiliation: Open Targets, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.|European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.
authors.forename: A Patrícia
authors.initials: AP
authors.lastname: Bento
authors.affiliation: Open Targets, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.|European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.
authors.forename: Tony
authors.initials: T
authors.lastname: Burdett
authors.affiliation: Open Targets, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.|European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.
authors.forename: Antonio
authors.initials: A
authors.lastname: Fabregat
authors.affiliation: Open Targets, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.|Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.
authors.forename: Simon
authors.initials: S
authors.lastname: Forbes
authors.affiliation: Open Targets, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.|European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.
authors.forename: Anna
authors.initials: A
authors.lastname: Gaulton
authors.affiliation: Open Targets, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.|European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.
authors.forename: Cristina Yenyxe
authors.initials: CY
authors.lastname: Gonzalez
authors.affiliation: Open Targets, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.|European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.|National Center for Protein Research, No. 38, Life Science Park Road, Changping District, 102206 Beijing, China.
authors.forename: Henning
authors.initials: H
authors.lastname: Hermjakob
authors.affiliation: Open Targets, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.|European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.
authors.forename: Anne
authors.initials: A
authors.lastname: Hersey
authors.affiliation: Open Targets, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.|European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.
authors.forename: Steven
authors.initials: S
authors.lastname: Jupe
authors.affiliation: Open Targets, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.|European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.
authors.forename: Şenay
authors.initials: Ş
authors.lastname: Kafkas
authors.affiliation: Open Targets, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.|European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.
authors.forename: Maria
authors.initials: M
authors.lastname: Keays
authors.affiliation: Open Targets, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.|European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.
authors.forename: Catherine
authors.initials: C
authors.lastname: Leroy
authors.affiliation: Open Targets, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.|European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.
authors.forename: Francisco-Javier
authors.initials: FJ
authors.lastname: Lopez
authors.affiliation: Open Targets, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.|European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.
authors.forename: Maria Paula
authors.initials: MP
authors.lastname: Magarinos
authors.affiliation: Open Targets, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.|European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.
authors.forename: James
authors.initials: J
authors.lastname: Malone
authors.affiliation: Open Targets, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.|European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.
authors.forename: Johanna
authors.initials: J
authors.lastname: McEntyre
authors.affiliation: Open Targets, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.|European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.
authors.forename: Alfonso
authors.initials: A
authors.lastname: Munoz-Pomer Fuentes
authors.affiliation: Open Targets, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.|European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.
authors.forename: Claire
authors.initials: C
authors.lastname: O'Donovan
authors.affiliation: Open Targets, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.|European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.
authors.forename: Irene
authors.initials: I
authors.lastname: Papatheodorou
authors.affiliation: Open Targets, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.|European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.
authors.forename: Helen
authors.initials: H
authors.lastname: Parkinson
authors.affiliation: Open Targets, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.|European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.
authors.forename: Barbara
authors.initials: B
authors.lastname: Palka
authors.affiliation: Open Targets, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.|European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.
authors.forename: Justin
authors.initials: J
authors.lastname: Paschall
authors.affiliation: Open Targets, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.|European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.
authors.forename: Robert
authors.initials: R
authors.lastname: Petryszak
authors.affiliation: Open Targets, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.|European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.
authors.forename: Naruemon
authors.initials: N
authors.lastname: Pratanwanich
authors.affiliation: Open Targets, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.|European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.
authors.forename: Sirarat
authors.initials: S
authors.lastname: Sarntivijal
authors.affiliation: Open Targets, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.|European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.
authors.forename: Gary
authors.initials: G
authors.lastname: Saunders
authors.affiliation: Open Targets, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.|European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Sidiropoulos
authors.affiliation: Open Targets, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.|European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.
authors.forename: Thomas
authors.initials: T
authors.lastname: Smith
authors.affiliation: Open Targets, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.|Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.
authors.forename: Zbyslaw
authors.initials: Z
authors.lastname: Sondka
authors.affiliation: Open Targets, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.|European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.
authors.forename: Oliver
authors.initials: O
authors.lastname: Stegle
authors.affiliation: Open Targets, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.|European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.
authors.forename: Y Amy
authors.initials: YA
authors.lastname: Tang
authors.affiliation: Open Targets, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.|European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.
authors.forename: Edward
authors.initials: E
authors.lastname: Turner
authors.affiliation: Open Targets, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.|European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.
authors.forename: Brendan
authors.initials: B
authors.lastname: Vaughan
authors.affiliation: Open Targets, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.|European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.
authors.forename: Olga
authors.initials: O
authors.lastname: Vrousgou
authors.affiliation: Open Targets, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.|European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.
authors.forename: Xavier
authors.initials: X
authors.lastname: Watkins
authors.affiliation: Open Targets, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.|European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.
authors.forename: Maria-Jesus
authors.initials: MJ
authors.lastname: Martin
authors.affiliation: Open Targets, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.|GSK, Medicines Research Center, Gunnels Wood Road, Stevenage, SG1 2NY, UK.
authors.forename: Philippe
authors.initials: P
authors.lastname: Sanseau
authors.affiliation: European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.
authors.forename: Jessica
authors.initials: J
authors.lastname: Vamathevan
authors.affiliation: Open Targets, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.|European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.
authors.forename: Ewan
authors.initials: E
authors.lastname: Birney
authors.affiliation: Open Targets, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.|European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.|Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Barrett
authors.affiliation: Open Targets, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK dunham@ebi.ac.uk.|European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.
authors.forename: Ian
authors.initials: I
authors.lastname: Dunham
mesh_terms: D019295:Computational Biology / Q000379:methods*; D016208:Databases, Factual; D006801:Humans; D058990:Molecular Targeted Therapy / Q000379:methods; D015203:Reproducibility of Results; D057386:Search Engine; D012984:Software; D064878:Web Browser; D057188:Workflow