title: Effect of naloxone on intravenous fentanyl patient-controlled analgesia after laparoscopic cholecystectomy.
abstract: This study aims to evaluate the effect of naloxone on intravenous fentanyl patient-controlled analgesia after laparoscopic cholecystectomy under total intravenous anesthesia.A total of 90 patients, who underwent intravenous fentanyl patient-controlled analgesia after laparoscopic cholecystectomy under total intravenous anesthesia, were included into this study. All patients were randomly divided into 3 groups (each group, n=30): naloxone group (naloxone+fentanyl), tropisetron group (tropisetron+fentanyl), and fentanyl group (fentanyl). Patients in each group were given a corresponding dose of naloxone. Postoperative analgesia effect and the incidence of side effects such as nausea and vomiting were observed.Small doses of naloxone or tropisetron combined with fentanyl used for intravenous patient-controlled analgesia can significantly reduce the incidence of nausea and vomiting. Six hours after surgery, visual analogue scale (VAS) scores were significantly lower in patients that underwent intravenous patient-controlled analgesia using low-dose naloxone combined with fentanyl compared with patients who received fentanyl alone; however, the postoperative analgesic effect of tropisetron was not observed. Compared with the combination of tropisetron and fentanyl, low-dose naloxone combined with fentanyl can obviously reduce the incidence of nausea and vomiting in patients who underwent intravenous patient-controlled analgesia after laparoscopic cholecystectomy, and enhance the analgesic effect of fentanyl 6 hours after surgery.Low-dose naloxone can reduce the incidence of nausea and vomiting in patients who underwent laparoscopic cholecystectomy under total intravenous anesthesia, and exhibits a certain synergic analgesic effect.
authors.affiliation: Department of Anesthesiology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China Department of Anesthesiology, Affiliated Hospital of Yan'an University, Yan'an, Shaanxi, China Digestive Internal Medicine, Affiliated Hospital of Yan'an University, Yan'an, Shaanxi, China Operation Room, Affiliated Hospital of Yan'an University, Yan'an, Shaanxi, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Zheng
authors.forename: Wen
authors.initials: W
authors.lastname: Han
authors.forename: Xiao-Dong
authors.initials: XD
authors.lastname: Han
authors.forename: Xiao-Yuan
authors.initials: XY
authors.lastname: Ma
authors.forename: Pengbo
authors.initials: P
authors.lastname: Zhang
mesh_terms: D000368:Aged; D016058:Analgesia, Patient-Controlled; D000701:Analgesics, Opioid / Q000008:administration & dosage*; D018686:Anesthetics, Intravenous / Q000008:administration & dosage*; D000932:Antiemetics / Q000008:administration & dosage*; D017081:Cholecystectomy, Laparoscopic; D004359:Drug Therapy, Combination; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage*; D006801:Humans; D007211:Indoles / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D009270:Naloxone / Q000008:administration & dosage*; D009292:Narcotic Antagonists / Q000008:administration & dosage*; D010147:Pain Measurement; D010149:Postoperative Pain / Q000188:drug therapy*; D020250:Postoperative Nausea and Vomiting / Q000517:prevention & control*; D000077526:Tropisetron
chemical_list: D000701:Analgesics, Opioid; D018686:Anesthetics, Intravenous; D000932:Antiemetics; D007211:Indoles; D009292:Narcotic Antagonists; D009270:Naloxone; D000077526:Tropisetron; D005283:Fentanyl