title: Preparation of magnetic mesoporous silica nanoparticles as a multifunctional platform for potential drug delivery and hyperthermia.
abstract: We report the preparation of magnetic mesoporous silica (MMS) nanoparticles with the potential multifunctionality of drug delivery and magnetic hyperthermia. Carbon-encapsulated magnetic colloidal nanoparticles (MCN@C) were used to coat mesoporous silica shells for the formation of the core-shell structured MMS nanoparticles (MCN@C/mSiO2), and the rattle-type structured MMS nanoparticles (MCN/mSiO2) were obtained after the removal of the carbon layers from MCN@C/mSiO2nanoparticles. The morphology, structure, magnetic hyperthermia ability, drug release behavior,in vitrocytotoxicity and cellular uptake of MMS nanoparticles were investigated. The results revealed that the MCN@C/mSiO2and MCN/mSiO2nanoparticles had spherical morphology and average particle sizes of 390 and 320 nm, respectively. The MCN@C/mSiO2nanoparticles exhibited higher magnetic hyperthermia ability compared to the MCN/mSiO2nanoparticles, but the MCN/mSiO2nanoparticles had higher drug loading capacity. Both MCN@C/mSiO2and MCN/mSiO2nanoparticles had similar drug release behavior with pH-controlled release and temperature-accelerated release. Furthermore, the MCN@C/mSiO2and MCN/mSiO2nanoparticles showed low cytotoxicity and could be internalized into HeLa cells. Therefore, the MCN@C/mSiO2and MCN/mSiO2nanoparticles would be promising for the combination of drug delivery and magnetic hyperthermia treatment in cancer therapy.
authors.affiliation: School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology , Shanghai , P.R. China.
authors.forename: Xia
authors.initials: X
authors.lastname: Yu
authors.affiliation: School of Materials Science and Engineering, University of Shanghai for Science and Technology , Shanghai , P.R. China.
authors.forename: Yufang
authors.initials: Y
authors.lastname: Zhu
keywords: 102 Porous/Nanoporous/Nanostructured materials; 211 Scaffold/Tissue engineering/Drug delivery; 30 Bio-inspired and biomedical materials; Mesoporous nanoparticles; drug delivery; magnetic hyperthermia; multifunctionality