title: Effects of the short-term application of pantoprazole combined with aspirin and clopidogrel in the treatment of acute STEMI.
abstract: The aim of the present study was to determine the effects of the short-term application of pantoprazole on the co-treatment of acute ST-segment elevation myocardial infarction (STEMI) with aspirin and clopidogrel. A total of 207 acute patients showing primary symptoms of STEMI, who received successful emergent percutaneous coronary intervention treatment during hospitalization were randomly divided into two groups. In the test group proton pump inhibitors (PPIs), the patients were treated with a combination of aspirin and clopidogrel and pantoprazole, while those in the control group were treated only with aspirin and clopidogrel. Gastrointestinal bleeding events and major adverse cardiac events (MACEs) were observed in the two groups. Gastrointestinal bleeding events of the two groups mostly occurred within the first week of hospitalization, although the incidence in the PPIs group was significantly higher than that in the control group (p<0.05). However, no significant difference was observed for the incidence of MACEs between the two groups (p>0.05). In conclusion, the results of the present study have shown that the short-term application of pantoprazole combined with aspirin and clopidogrel does not increase the incidence of MACEs in patients with acute STEMI, reduces the risk of gastrointestinal bleeding, and is thus worth promoting clinically, particularly for high-risk groups.
authors.affiliation: Department of Cardiology, Xuzhou Central Hospital, Xuzhou, Jiangsu 221009, P.R. China.
authors.forename: Peng
authors.initials: P
authors.lastname: Wei
authors.affiliation: Department of Cardiology, Xuzhou Central Hospital, Xuzhou, Jiangsu 221009, P.R. China.
authors.forename: Yi-Gang
authors.initials: YG
authors.lastname: Zhang
authors.affiliation: Department of Cardiology, The First Affiliated Hospital, Soochow University, Suzhou, Jiangsu 215006, P.R. China.
authors.forename: Lin
authors.initials: L
authors.lastname: Ling
authors.affiliation: Departments of Science and Education, Xuzhou Central Hospital, Xuzhou, Jiangsu 221009, P.R. China.
authors.forename: Zi-Qi
authors.initials: ZQ
authors.lastname: Tao
authors.affiliation: Department of Cardiology, Xuzhou Central Hospital, Xuzhou, Jiangsu 221009, P.R. China.
authors.forename: Li-Ya
authors.initials: LY
authors.lastname: Ji
authors.affiliation: Department of Geriatrics, Changhai Hospital of The Second Military Medical University, Shanghai 200433, P.R. China.
authors.forename: Jie
authors.initials: J
authors.lastname: Bai
authors.affiliation: Department of Cardiology, Xuzhou Central Hospital, Xuzhou, Jiangsu 221009, P.R. China.
authors.forename: Bin
authors.initials: B
authors.lastname: Zong
authors.affiliation: Department of Cardiology, Xuzhou Central Hospital, Xuzhou, Jiangsu 221009, P.R. China.
authors.forename: Chun-Ying
authors.initials: CY
authors.lastname: Jiang
authors.affiliation: Department of Cardiology, Xuzhou Central Hospital, Xuzhou, Jiangsu 221009, P.R. China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Department of Cardiology, Xuzhou Central Hospital, Xuzhou, Jiangsu 221009, P.R. China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Fu
authors.affiliation: Department of Cardiology, The First Affiliated Hospital, Soochow University, Suzhou, Jiangsu 215006, P.R. China.
authors.forename: Xiang-Jun
authors.initials: XJ
authors.lastname: Yang
keywords: ST-segment elevation myocardial infarction; aspirin; clopidogrel; major adverse cardiac events; pantoprazole