title: Medication Adherence Pattern and Factors affecting Adherence in Helicobacter Pylori Eradication Therapy.
abstract: Background Helicobacter pylori (H. pylori) infection is the most common chronic bacterial infection worldwide affecting approximately half of the world's population. A number of screening tests as well as complex multi-drug therapies are available for the detection and treatment of H. pylori infection. However, the optimum eradication rates of H. pylori infection can only be achieved if adherence to drug therapy is higher. Therefore, it is of utmost importance to determine the factors leading to poor adherence to obtain successful treatment outcomes. Objective To determine the medication adherence pattern in patients with H. pylori infection and assess the factors associated with non-adherence to the prescribed drug therapy. Method Patients meeting the inclusion criteria who were confirmed as H. pylori positive by rapid urease test (histopathology) and/ or stool antigen test and those under H. pylori eradication therapy were considered. Informed consent was taken from the patients or from the patient party in incapacitated patients. They were then interviewed using structured questionnaire. Statistical analysis was done using SPSS version 20 and a p-value < 0.05 was considered as statistically significant. Result Among the 70 participants included in this study, 57.10% (n=40) of them were males. The mean (±SD) age of the patients was 42.36 years (±17.93). Higher number (85.70% (n=60)) of the patients were adherent to the recommended medication. Forgetfulness was the reason for missing dose in a majority (80% (n=8)) of the nonadherent patients. A highly significant association (p<0.05) was observed between adherence and absence of symptomatic relief. However, there was no statistically significant association (p>0.05) between patients' adherence to gender, age, literacy, and the prescribed treatment regimen. Conclusion Majority of the patients with H. pylori infection were adherent to medication. Forgetfulness was the major reason for missing dose in the non-adherent patients.
authors.affiliation: Department of Pharmacology, School of Medical Sciences, Kathmandu University. Research and Development Division, Dhulikhel Hospital, Kathmandu University Hospital, Dhulikhel, Kavre, Nepal.
authors.forename: S
authors.initials: S
authors.lastname: Shakya Shrestha
authors.affiliation: Department of Pharmacology, School of Medical Sciences, Kathmandu University.
authors.forename: M
authors.initials: M
authors.lastname: Bhandari
authors.affiliation: Department of Pharmacology, School of Medical Sciences, Kathmandu University.
authors.forename: S R
authors.initials: SR
authors.lastname: Thapa
authors.affiliation: Department of Pharmacology, School of Medical Sciences, Kathmandu University. Research and Development Division, Dhulikhel Hospital, Kathmandu University Hospital, Dhulikhel, Kavre, Nepal.
authors.forename: R
authors.initials: R
authors.lastname: Shrestha
authors.affiliation: Department of Pharmacology, School of Medical Sciences, Kathmandu University.
authors.forename: R
authors.initials: R
authors.lastname: Poudyal
authors.affiliation: Department of Gastroenterology, Dhulikhel Hospital, Kathmandu University Hospital, Dhulikhel, Kavre, Nepal.
authors.forename: B
authors.initials: B
authors.lastname: Purbey
authors.affiliation: Department of Gastroenterology, Dhulikhel Hospital, Kathmandu University Hospital, Dhulikhel, Kavre, Nepal.
authors.forename: R B
authors.initials: RB
authors.lastname: Gurung
mesh_terms: D000328:Adult; D000368:Aged; D004359:Drug Therapy, Combination; D005260:Female; D016481:Helicobacter Infections / Q000188:drug therapy*; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome; D016903:Drug Monitoring