title: Morphogenesis of Experimental Infection Caused by Plasmid Variants of Yersinia pseudotuberculosis.
abstract: The dynamics of pathomorphological changes in response to infection with plasmid variants of Yersinia pseudotuberculosis was studied in experimental animals. Variability of cell injuries in pseudotuberculosis histopathology depended on the plasmid-associated virulence of the infection agent. Infection with highly virulent two-plasmid strain pYV48:pVM82 MDa and Y. pseudotuberculosis strain with low virulence with the only plasmid pVM82 MDa led to the development of cell destruction (necrosis and apoptosis) in the target organs. Apoptosis predominated in response to infection by plasmid variant pVM82 MDa with low virulence.
authors.affiliation: G. P. Somov Research Institute of Epidemiology and Microbiology, Vladivostok, Russia. l_somova@mail.ru.
authors.forename: L M
authors.initials: LM
authors.lastname: Somova
authors.affiliation: G. P. Somov Research Institute of Epidemiology and Microbiology, Vladivostok, Russia.
authors.forename: E I
authors.initials: EI
authors.lastname: Drobot
authors.affiliation: G. P. Somov Research Institute of Epidemiology and Microbiology, Vladivostok, Russia.|Pacific State Medical University, Ministry of Health of the Russian Federation, Vladivostok, Russia.
authors.forename: N G
authors.initials: NG
authors.lastname: Plekhova
authors.affiliation: G. P. Somov Research Institute of Epidemiology and Microbiology, Vladivostok, Russia.
authors.forename: I N
authors.initials: IN
authors.lastname: Lyapun
authors.affiliation: G. P. Somov Research Institute of Epidemiology and Microbiology, Vladivostok, Russia.
authors.forename: F N
authors.initials: FN
authors.lastname: Shubin
mesh_terms: D000818:Animals; D021461:Animals, Outbred Strains; D017209:Apoptosis; D022781:Hepatocytes / Q000382:microbiology / Q000473:pathology; D006801:Humans; D007274:Injections, Intraperitoneal; D007728:Kupffer Cells / Q000382:microbiology / Q000473:pathology; D008099:Liver / Q000382:microbiology / Q000473:pathology; D008168:Lung / Q000382:microbiology / Q000473:pathology; D008198:Lymph Nodes / Q000382:microbiology / Q000473:pathology; D008297:Male; D051379:Mice; D009336:Necrosis / Q000382:microbiology / Q000473:pathology*; D010586:Phagocytes / Q000382:microbiology / Q000473:pathology; D010957:Plasmids / Q000737:chemistry / Q000378:metabolism*; D013045:Species Specificity; D013154:Spleen / Q000382:microbiology / Q000473:pathology; D014774:Virulence; D015011:Yersinia pseudotuberculosis / Q000235:genetics / Q000254:growth & development / Q000472:pathogenicity*; D015012:Yersinia pseudotuberculosis Infections / Q000382:microbiology / Q000473:pathology*
keywords: Yersinia pseudotuberculosis plasmid variants; apoptosis; necrosis; pathohistology; pseudotuberculosis