title: A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape.
abstract: Large consortia have revealed hundreds of genetic loci associated with anthropometric traits, one trait at a time. We examined whether genetic variants affect body shape as a composite phenotype that is represented by a combination of anthropometric traits. We developed an approach that calculates averaged PCs (AvPCs) representing body shape derived from six anthropometric traits (body mass index, height, weight, waist and hip circumference, waist-to-hip ratio). The first four AvPCs explain >99% of the variability, are heritable, and associate with cardiometabolic outcomes. We performed genome-wide association analyses for each body shape composite phenotype across 65 studies and meta-analysed summary statistics. We identify six novel loci: LEMD2 and CD47 for AvPC1, RPS6KA5/C14orf159 and GANAB for AvPC3, and ARL15 and ANP32 for AvPC4. Our findings highlight the value of using multiple traits to define complex phenotypes for discovery, which are not captured by single-trait analyses, and may shed light onto new pathways.
authors.affiliation: Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany.
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authors.identifier: 0000-0001-7999-5538
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authors.identifier: 0000-0002-8309-094X
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authors.affiliation: The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.|The Department of Preventive Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
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authors.affiliation: Department of Health Sciences, University of Milano at San Paolo Hospital, 20139 Milano, Italy.|Filarete Foundation, Genomic and Bioinformatics Unit, Milano 20139, Italy.
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authors.affiliation: Wellcome Trust Sanger Institute, Human Genetics, Hinxton, Cambridge CB10 1SA, UK.|Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, 17671 Athens, Greece.
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authors.affiliation: Institute of Epidemiology I, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany.|Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany.
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authors.affiliation: Folkhälsan Research Centre, FI-00290 Helsinki, Finland.|Department of Chronic Disease Prevention, National Institute for Health and Welfare, FI-00271 Helsinki, Finland.|Department of General Practice and Primary Health Care, University of Helsinki, FI-00014 Helsinki, Finland.
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authors.affiliation: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
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authors.affiliation: Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany.|German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany.|Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany.
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authors.affiliation: Department of Medicine, Karolinska Institutet, Stockholm, Sweden.|Department of Medicine Solna, Atherosclerosis Research Unit, Karolinska Institutet, 17176 Stockholm 17176, Sweden.|Center for Molecular Medicine, Karolinska University Hospital, 17176 Stockholm, Sweden.
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authors.affiliation: Department of Health, National Institute for Health and Welfare (THL), FI-00271 Helsinki, Finland.
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authors.affiliation: Department of Public Health and General Practice, Norwegian University of Science and Technology, 7489 Trondheim, Norway.
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authors.affiliation: Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, 17475 Greifswald, Germany.
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authors.affiliation: Department of Biological Psychology, VU University, 1081BT Amsterdam, The Netherlands.
authors.forename: Jouke-Jan
authors.initials: JJ
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authors.affiliation: Pathwest Laboratory Medicine of Western Australia, Nedlands, Western Australia 6009, Australia.|School of Pathology and Laboratory Medicine, University of Western Australia, Nedlands, Western Australia 6009, Australia.|School of Population Health, University of Western Australia, Nedlands, Western Australia 6009, Australia.
authors.forename: Jennie
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authors.affiliation: Research Centre for Prevention and Health, Glostrup Hospital, 2600 Glostrup, Denmark.
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authors.affiliation: Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.
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authors.initials: PG
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authors.affiliation: Department of Epidemiology, Genetic Epidemiology Unit, Erasmus University Medical Center, 3015GE Rotterdam, The Netherlands.
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authors.affiliation: Institute for Community Medicine, University Medicine Greifswald, 17475 Greifswald, Germany.
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authors.initials: T
authors.lastname: Ittermann
authors.affiliation: Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK.|Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
authors.forename: Shapour
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authors.affiliation: Department of Pulmonary Physiology and Sleep Medicine, Sir Charles Gairdner Hospital, Nedlands, Western Australia 6009, Australia.
authors.forename: Alan L
authors.initials: AL
authors.lastname: James
authors.affiliation: Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.|Faculty of Medicine, University of Aalborg, 9220 Aalborg, Denmark.|Research Centre for Prevention and Health, Capital Region of Denmark, DK2600 Glostrup, Denmark.
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authors.affiliation: Department of Health, National Institute for Health and Welfare (THL), FI-00271 Helsinki, Finland.
authors.forename: Pekka
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authors.affiliation: Department of Health, National Institute for Health and Welfare (THL), FI-00271 Helsinki, Finland.
authors.forename: Antti
authors.initials: A
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authors.affiliation: Faculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, University of Copenhagen, 2100 Copenhagen, Denmark.
authors.forename: Johanne
authors.initials: J
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authors.affiliation: Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.
authors.forename: Anne E
authors.initials: AE
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authors.affiliation: Department of Clinical Physiology, Tampere University Hospital, FI-33521 Tampere, Finland.|Department of Clinical Physiology, University of Tampere School of Medicine, FI-33014 Tampere, Finland.
authors.forename: Mika
authors.initials: M
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authors.affiliation: Echinos Medical Centre, 67300 Echinos, Greece.
authors.forename: Maria
authors.initials: M
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authors.affiliation: Clinical Gerontology Unit, Box 251, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ, UK.
authors.forename: Kay
authors.initials: K
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authors.affiliation: Faculty of Medicine, Institute of Health Sciences, University of Oulu, Oulu F1-90014, Finland.|Unit of General Practice, Oulu University Hospital, Oulu FI-90029, Finland.
authors.forename: Sirkka M
authors.initials: SM
authors.lastname: Keinanen-Kiukaanniemi
authors.affiliation: National Institute for Health and Welfare, FI-00271 Helsinki, Finland.
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authors.initials: L
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authors.affiliation: Department of Health, National Institute for Health and Welfare (THL), FI-00271 Helsinki, Finland.
authors.forename: Paul B
authors.initials: PB
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authors.affiliation: National Institute for Health and Welfare, FI-00271 Helsinki, Finland.|Department of Medicine and Abdominal Center: Endocrinology, University of Helsinki and Helsinki University Central Hospital,, 00029 Helsinki, Finland.|Minerva Foundation Institute for Medical Research, 00290 Helsinki, Finland.
authors.forename: Heikki A
authors.initials: HA
authors.lastname: Koistinen
authors.affiliation: Department of Public Health, Faculty of Medicine, University of Split, 21000 Split, Croatia.
authors.forename: Ivana
authors.initials: I
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authors.affiliation: Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK.
authors.forename: Ishminder K
authors.initials: IK
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authors.affiliation: Department of Health, National Institute for Health and Welfare (THL), FI-00271 Helsinki, Finland.
authors.forename: Seppo
authors.initials: S
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authors.affiliation: University of Leipzig, IFB Adiposity Diseases, 04103 Leipzig, Germany.
authors.forename: Peter
authors.initials: P
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authors.affiliation: Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK.|Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
authors.forename: Theodosios
authors.initials: T
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authors.affiliation: Kuopio University Hospital, 70029 Kuopio, Finland.|Department of Clinical Physiology and Nuclear Medicine, University of Eastern Finland, FI-70211 Kuopio, Finland.
authors.forename: Tomi
authors.initials: T
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authors.affiliation: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.|Department of Epidemiology and Public Health, UCL, London WC1E 6BT, UK.
authors.forename: Claudia
authors.initials: C
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authors.affiliation: Department of Epidemiology and Biostatistics, MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College, London W12 0NN, UK.
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authors.initials: AM
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authors.affiliation: Institute of Human Genetics, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Lichtner
authors.affiliation: Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 2142, USA.|Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.|The Big Data Institute, University of Oxford, Oxford OX3 7LJ, UK.
authors.forename: Cecilia M
authors.initials: CM
authors.lastname: Lindgren
authors.affiliation: Department of Health, National Institute for Health and Welfare (THL), FI-00271 Helsinki, Finland.
authors.forename: Jaana
authors.initials: J
authors.lastname: Lindström
authors.affiliation: Research Centre for Prevention and Health, Glostrup Hospital, 2600 Glostrup, Denmark.|Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.|Department of Clinical Experimental Research, Rigshospitalet, 2600 Glostrup, Denmark.
authors.forename: Allan
authors.initials: A
authors.lastname: Linneberg
authors.affiliation: Institute for Community Medicine, University Medicine Greifswald, 17475 Greifswald, Germany.
authors.forename: Roberto
authors.initials: R
authors.lastname: Lorbeer
authors.affiliation: Department of Internal Medicine and Clinical Nutrition, Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 413 45 Gothenburg, Sweden.
authors.forename: Mattias
authors.initials: M
authors.lastname: Lorentzon
authors.affiliation: Strangeways Research Laboratory Wort's Causeway, Cambridge CB1 8RN, UK.
authors.forename: Robert
authors.initials: R
authors.lastname: Luben
authors.affiliation: Steno Diabetes Center A/S, DK-2820 Gentofte, Denmark.|Lund University Diabetes Centre and Department of Clinical Science, Diabetes &Endocrinology Unit, Lund University, 221 00 Malmö, Sweden.
authors.forename: Valeriya
authors.initials: V
authors.lastname: Lyssenko
authors.affiliation: Department of Health, National Institute for Health and Welfare (THL), FI-00271 Helsinki, Finland.
authors.forename: Satu
authors.initials: S
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authors.affiliation: Chair of Nephrology, Università Vita Salute San Raffaele and Genomics of Renal Diseases and Hypertension Unit, IRCCS San Raffaele Scientific Institute, Milan 20139, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Manunta
authors.affiliation: Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, Netherlands.
authors.forename: Irene Mateo
authors.initials: IM
authors.lastname: Leach
authors.affiliation: School of Social and Community Medicine, University of Bristol, Bristol BS82BN, UK.
authors.forename: Wendy L
authors.initials: WL
authors.lastname: McArdle
authors.affiliation: Department of Biostatistics, University of Washington, Seattle, Washington 98195, USA.|Cardiovascular Health Research Unit, University of Washington, Seattle, Washington 98101, USA.|Divison of Public Health Sciences, Program in Biostatistics and Biomathematics, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
authors.forename: Barbara
authors.initials: B
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authors.affiliation: Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
authors.forename: Karen L
authors.initials: KL
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authors.affiliation: Estonian Genome Center, University of Tartu, Tartu 51010, Estonia.
authors.forename: Evelin
authors.initials: E
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authors.affiliation: Estonian Genome Center, University of Tartu, Tartu 51010, Estonia.
authors.forename: Lili
authors.initials: L
authors.lastname: Milani
authors.affiliation: Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK.
authors.forename: Rebecca
authors.initials: R
authors.lastname: Mills
authors.affiliation: Division of Endocrinology, Diabetes &Nutrition, Department of Medicine, Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.
authors.forename: May E
authors.initials: ME
authors.lastname: Montasser
authors.affiliation: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.|Department of Biostatistics, University of Liverpool, Liverpool L69 3GA, UK.
authors.forename: Andrew P
authors.initials: AP
authors.lastname: Morris
authors.affiliation: Center for Evidence Based Healthcare, University of Dresden, Medical Faculty Carl Gustav Carus, Dresden, 01307, Germany.
authors.forename: Gabriele
authors.initials: G
authors.lastname: Müller
authors.affiliation: Department of Respiratory Medicine, Sir Charles Gairdner Hospital, Nedlands, West Australia 6009, Australia.
authors.forename: Arthur W
authors.initials: AW
authors.lastname: Musk
authors.affiliation: Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland 20892, USA.
authors.forename: Narisu
authors.initials: N
authors.lastname: Narisu
authors.affiliation: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.|MRC Unit for Lifelong Health &Ageing at UCL, London WC1B 5JU, UK.|Department of Paediatrics, University of Cambridge, Cambridge CB2 0QQ, UK.
authors.forename: Ken K
authors.initials: KK
authors.lastname: Ong
authors.affiliation: Department of Epidemiology, Genetic Epidemiology Unit, Erasmus University Medical Center, 3015GE Rotterdam, The Netherlands.
authors.forename: Ben A
authors.initials: BA
authors.lastname: Oostra
authors.affiliation: MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK.
authors.forename: Clive
authors.initials: C
authors.lastname: Osmond
authors.affiliation: Institute for Molecular Medicine Finland, University of Helsinki, FI-00290 Helsinki, Finland.|Massachusetts General Hospital, Center for Human Genetic Research, Psychiatric and Neurodevelopmental Genetics Unit, Boston, Massachusetts 02114, USA.
authors.forename: Aarno
authors.initials: A
authors.lastname: Palotie
authors.affiliation: Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota 55455-0381, USA.
authors.forename: James S
authors.initials: JS
authors.lastname: Pankow
authors.affiliation: MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol BS8 1TH, UK.
authors.forename: Lavinia
authors.initials: L
authors.lastname: Paternoster
authors.affiliation: Department of Psychiatry and EMGO Institute for Health and Care Research, VU University Medical Center, AJ Ernstraat 1887, 1081 HL Amsterdam, The Netherlands.
authors.forename: Brenda W
authors.initials: BW
authors.lastname: Penninx
authors.affiliation: Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), 39100 Bolzano, Italy.|Affiliated Institute of the University of Lübeck, 23562 Lübeck, Germany.
authors.forename: Irene
authors.initials: I
authors.lastname: Pichler
authors.affiliation: Istituto di Ricerca Genetica e Biomedica, CNR, 9042 Monserrato, Italy.
authors.forename: Maria G
authors.initials: MG
authors.lastname: Pilia
authors.affiliation: Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, EH8 9AG Teviot Place, Edinburgh, Scotland.|Department of Public Health, Faculty of Medicine, University of Split, 21000 Split, Croatia.
authors.forename: Ozren
authors.initials: O
authors.lastname: Polašek
authors.affiliation: Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), 39100 Bolzano, Italy.|Affiliated Institute of the University of Lübeck, 23562 Lübeck, Germany.|Department of Neurology, University of Lübeck, 23562 Lübeck, Germany.|Department of Neurology, General Central Hospital, 39100 Bolzano, Italy.
authors.forename: Peter P
authors.initials: PP
authors.lastname: Pramstaller
authors.affiliation: Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, FI-20521 Turku, Finland.|Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, FI-20520 Turku, Finland.
authors.forename: Olli T
authors.initials: OT
authors.lastname: Raitakari
authors.affiliation: Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA.
authors.forename: Tuomo
authors.initials: T
authors.lastname: Rankinen
authors.affiliation: Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri 63110, USA.|Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
authors.forename: D C
authors.initials: DC
authors.lastname: Rao
authors.affiliation: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.|Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford OX3 7LJ, UK.|Wellcome Trust Sanger Institute, Human Genetics, Hinxton CB10 1HH, UK.
authors.forename: Nigel W
authors.initials: NW
authors.lastname: Rayner
authors.affiliation: Faculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, University of Copenhagen, 2100 Copenhagen, Denmark.
authors.forename: Rasmus
authors.initials: R
authors.lastname: Ribel-Madsen
authors.affiliation: Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri 63110, USA.|Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
authors.forename: Treva K
authors.initials: TK
authors.lastname: Rice
authors.affiliation: Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford OX3 7LJ, UK.|MRC Unit for Lifelong Health &Ageing at UCL, London WC1B 5JU, UK.
authors.forename: Marcus
authors.initials: M
authors.lastname: Richards
authors.affiliation: Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02215, USA.|Harvard Medical School, Boston, Massachusetts, 02115, USA.
authors.forename: Paul M
authors.initials: PM
authors.lastname: Ridker
authors.affiliation: Department of Epidemiology, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands.|Department of Internal Medicine, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands.
authors.forename: Fernando
authors.initials: F
authors.lastname: Rivadeneira
authors.affiliation: Division of Endocrinology, Diabetes &Nutrition, Department of Medicine, Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.
authors.forename: Kathy A
authors.initials: KA
authors.lastname: Ryan
authors.affiliation: Istituto di Ricerca Genetica e Biomedica, CNR, 9042 Monserrato, Italy.
authors.forename: Serena
authors.initials: S
authors.lastname: Sanna
authors.affiliation: Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA.
authors.forename: Mark A
authors.initials: MA
authors.lastname: Sarzynski
authors.affiliation: Department of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands.
authors.forename: Salome
authors.initials: S
authors.lastname: Scholtens
authors.affiliation: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.
authors.forename: Robert A
authors.initials: RA
authors.lastname: Scott
authors.affiliation: Department of Genomics of Common Disease, School of Public Health, Imperial College London, London W12 0NN, UK.|Biocenter Oulu, University of Oulu, Oulu FI-90014, Finland.|Center For Life-Course Health Research, University of Oulu, FI-90014 Oulu, Finland.
authors.forename: Sylvain
authors.initials: S
authors.lastname: Sebert
authors.affiliation: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.|Wellcome Trust Sanger Institute, Human Genetics, Hinxton, Cambridge CB10 1SA, UK.
authors.forename: Lorraine
authors.initials: L
authors.lastname: Southam
authors.affiliation: Faculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, University of Copenhagen, 2100 Copenhagen, Denmark.
authors.forename: Thomas Hempel
authors.initials: TH
authors.lastname: Sparsø
authors.affiliation: deCODE Genetics, Amgen inc., 101 Reykjavik, Iceland.
authors.forename: Valgerdur
authors.initials: V
authors.lastname: Steinthorsdottir
authors.affiliation: Wellcome Trust Sanger Institute, Human Genetics, Hinxton, Cambridge CB10 1SA, UK.|William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.
authors.forename: Kathleen
authors.initials: K
authors.lastname: Stirrups
authors.affiliation: Department of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands.
authors.forename: Ronald P
authors.initials: RP
authors.lastname: Stolk
authors.affiliation: Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany.|Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, 81377 Munich, Germany.
authors.forename: Konstantin
authors.initials: K
authors.lastname: Strauch
authors.affiliation: Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA.
authors.forename: Heather M
authors.initials: HM
authors.lastname: Stringham
authors.affiliation: Department of Genetics, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands.
authors.forename: Morris A
authors.initials: MA
authors.lastname: Swertz
authors.affiliation: Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland 20892, USA.
authors.forename: Amy J
authors.initials: AJ
authors.lastname: Swift
authors.affiliation: Department of Medicine, University of Leipzig, 04103 Leipzig, Germany.
authors.forename: Anke
authors.initials: A
authors.lastname: Tönjes
authors.affiliation: Anogia Medical Centre, 74051 Anogia, Greece.
authors.forename: Emmanouil
authors.initials: E
authors.lastname: Tsafantakis
authors.affiliation: Department of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands.
authors.forename: Peter J
authors.initials: PJ
authors.lastname: van der Most
authors.affiliation: Department of Endocrinology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands.
authors.forename: Jana V
authors.initials: JV
authors.lastname: Van Vliet-Ostaptchouk
authors.affiliation: Department of Internal Medicine and Clinical Nutrition, Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 413 45 Gothenburg, Sweden.
authors.forename: Liesbeth
authors.initials: L
authors.lastname: Vandenput
authors.affiliation: Department of Health, National Institute for Health and Welfare (THL), FI-00271 Helsinki, Finland.
authors.forename: Erkki
authors.initials: E
authors.lastname: Vartiainen
authors.affiliation: Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.|Institute of Ophthalmology, University College London, London EC1V 9EL, UK.
authors.forename: Cristina
authors.initials: C
authors.lastname: Venturini
authors.affiliation: Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, Netherlands.
authors.forename: Niek
authors.initials: N
authors.lastname: Verweij
authors.affiliation: Department of Medicine, University of Turku, FI-20521 Turku, Finland.|Division of Medicine, Turku University Hospital, Turku, Finland.
authors.forename: Jorma S
authors.initials: JS
authors.lastname: Viikari
authors.affiliation: MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, EH4 2XU Edinburgh, Scotland.
authors.forename: Veronique
authors.initials: V
authors.lastname: Vitart
authors.affiliation: Institute of Nutrition and Functional Foods, Laval University, Québec, Québec, Canada G1V 0A6.|School of Nutrition, Laval University, Québec, Québec, Canada G1V 0A6.
authors.forename: Marie-Claude
authors.initials: MC
authors.lastname: Vohl
authors.affiliation: Department of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands.
authors.forename: Judith M
authors.initials: JM
authors.lastname: Vonk
authors.affiliation: Department of Internal Medicine, University Hospital Lausanne (CHUV) and University of Lausanne, 1011 Lausanne, Switzerland.
authors.forename: Gérard
authors.initials: G
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authors.affiliation: Institute for Molecular Medicine Finland, University of Helsinki, FI-00290 Helsinki, Finland.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Widén
authors.affiliation: Department of Biological Psychology, VU University, 1081BT Amsterdam, The Netherlands.
authors.forename: Gonneke
authors.initials: G
authors.lastname: Willemsen
authors.affiliation: Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, 9037 Tromsø, Norway.
authors.forename: Tom
authors.initials: T
authors.lastname: Wilsgaard
authors.affiliation: Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, 93053 Regensburg, Germany.
authors.forename: Thomas W
authors.initials: TW
authors.lastname: Winkler
authors.affiliation: MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, EH4 2XU Edinburgh, Scotland.
authors.forename: Alan F
authors.initials: AF
authors.lastname: Wright
authors.affiliation: Division of Endocrinology, Diabetes &Nutrition, Department of Medicine, Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.
authors.forename: Laura M
authors.initials: LM
authors.lastname: Yerges-Armstrong
authors.affiliation: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.
authors.forename: Jing
authors.initials: J
authors.lastname: Hua Zhao
authors.affiliation: Department of Internal Medicine, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands.
authors.forename: M Carola
authors.initials: MC
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authors.affiliation: Department of Biological Psychology, VU University, 1081BT Amsterdam, The Netherlands.
authors.forename: Dorret I
authors.initials: DI
authors.lastname: Boomsma
authors.affiliation: Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA.
authors.forename: Claude
authors.initials: C
authors.lastname: Bouchard
authors.affiliation: Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK.|Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK.|Imperial College Healthcare NHS Trust, London W12 0HS, UK.
authors.forename: John C
authors.initials: JC
authors.lastname: Chambers
authors.affiliation: Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02215, USA.|Harvard Medical School, Boston, Massachusetts, 02115, USA.
authors.forename: Daniel I
authors.initials: DI
authors.lastname: Chasman
authors.affiliation: Department of Health Sciences, University of Milano at San Paolo Hospital, 20139 Milano, Italy.|Filarete Foundation, Genomic and Bioinformatics Unit, Milano 20139, Italy.
authors.forename: Daniele
authors.initials: D
authors.lastname: Cusi
authors.affiliation: Department of Medicine, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, Netherlands.
authors.forename: Ron T
authors.initials: RT
authors.lastname: Gansevoort
authors.affiliation: Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany.|Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany.|Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Gieger
authors.affiliation: Faculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, University of Copenhagen, 2100 Copenhagen, Denmark.|Faculty of Health Sciences, University of Southern Denmark, 5000 Odense, Denmark.
authors.forename: Torben
authors.initials: T
authors.lastname: Hansen
authors.affiliation: Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), 39100 Bolzano, Italy.|Affiliated Institute of the University of Lübeck, 23562 Lübeck, Germany.
authors.forename: Andrew A
authors.initials: AA
authors.lastname: Hicks
authors.affiliation: Department of Medicine, Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.|Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
authors.forename: Frank
authors.initials: F
authors.lastname: Hu
authors.affiliation: Department of Public Health and General Practice, Norwegian University of Science and Technology, 7489 Trondheim, Norway.
authors.forename: Kristian
authors.initials: K
authors.lastname: Hveem
authors.affiliation: Biocenter Oulu, University of Oulu, Oulu FI-90014, Finland.|Unit of Primary Care, Oulu University Hospital, 90029 OYS Oulu, Finland.|Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment &Health, School of Public Health, Imperial College London W12 0NN, UK.|Faculty of Medicine, Center for Life Course Epidemiology, University of Oulu, P.O.Box 5000, FI-90014 Oulu, Finland.
authors.forename: Marjo-Riitta
authors.initials: MR
authors.lastname: Jarvelin
authors.affiliation: Department of Health, National Institute for Health and Welfare (THL), FI-00271 Helsinki, Finland.|Department of Chronic Disease Prevention, National Institute for Health and Welfare, FI-00271 Helsinki, Finland.|Children's Hospital, Helsinki University Hospital and University of Helsinki, FI-00029 Helsinki, Finland.|Department of Obstetrics and Gynecology, MRC Oulu, Oulu University Hospital and University of Oulu, FI-90029 Oulu, Finland.
authors.forename: Eero
authors.initials: E
authors.lastname: Kajantie
authors.affiliation: Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK.|Imperial College Healthcare NHS Trust, London W12 0HS, UK.|National Heart and Lung Institute, Imperial College London, London W12 0NN, UK.
authors.forename: Jaspal S
authors.initials: JS
authors.lastname: Kooner
authors.affiliation: MRC Unit for Lifelong Health &Ageing at UCL, London WC1B 5JU, UK.
authors.forename: Diana
authors.initials: D
authors.lastname: Kuh
authors.affiliation: Department of Medicine, University of Eastern Finland and Kuopio University Hospital, 70210 Kuopio, Finland.
authors.forename: Johanna
authors.initials: J
authors.lastname: Kuusisto
authors.affiliation: Department of Medicine, University of Eastern Finland and Kuopio University Hospital, 70210 Kuopio, Finland.
authors.forename: Markku
authors.initials: M
authors.lastname: Laakso
authors.affiliation: Kuopio Research Institute of Exercise Medicine, 70100 Kuopio, Finland.|Department of Physiology, Institute of Biomedicine, University of Eastern Finland, Kuopio Campus, 70210 Kuopio, Finland.
authors.forename: Timo A
authors.initials: TA
authors.lastname: Lakka
authors.affiliation: Department of Clinical Chemistry, University of Tampere School of Medicine, FI-33014 Tampere, Finland.|Department of Clinical Chemistry, Fimlab Laboratories and School of Medicine, University of Tampere, FI-33520 Tampere, Finland.
authors.forename: Terho
authors.initials: T
authors.lastname: Lehtimäki
authors.affiliation: Estonian Genome Center, University of Tartu, Tartu 51010, Estonia.
authors.forename: Andres
authors.initials: A
authors.lastname: Metspalu
authors.affiliation: Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, 9037 Tromsø, Norway.|Department of Clinical Medicine, Faculty of Health Sciences, University of Tromsø, 9037 Tromsø, Norway.
authors.forename: Inger
authors.initials: I
authors.lastname: Njølstad
authors.affiliation: Department of Internal Medicine and Clinical Nutrition, Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 413 45 Gothenburg, Sweden.
authors.forename: Claes
authors.initials: C
authors.lastname: Ohlsson
authors.affiliation: University of Groningen, University Medical Center Groningen, Interdisciplinary Center Psychopathology and Emotion Regulation, 9700 RB Groningen, The Netherlands.
authors.forename: Albertine J
authors.initials: AJ
authors.lastname: Oldehinkel
authors.affiliation: School of Public Health, University of Adelaide, Adelaide, South Australia 5005, Australia.|Robinson Research Institute, University of Adelaide, Adelaide, South Australia 5005, Australia.
authors.forename: Lyle J
authors.initials: LJ
authors.lastname: Palmer
authors.affiliation: Faculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, University of Copenhagen, 2100 Copenhagen, Denmark.
authors.forename: Oluf
authors.initials: O
authors.lastname: Pedersen
authors.affiliation: Department of Health, National Institute for Health and Welfare (THL), FI-00271 Helsinki, Finland.|Estonian Genome Center, University of Tartu, Tartu 51010, Estonia.|Institute for Molecular Medicine Finland, University of Helsinki, FI-00290 Helsinki, Finland.
authors.forename: Markus
authors.initials: M
authors.lastname: Perola
authors.affiliation: Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany.|Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany.|DZHK (German Centre for Cardiovascular Research), partnersite Munich Heart Alliance, 80802 Munich, Germany.
authors.forename: Annette
authors.initials: A
authors.lastname: Peters
authors.affiliation: Cardiovascular Health Research Unit, University of Washington, Seattle, Washington 98101, USA.|Department of Medicine, University of Washington, Seattle, Washington 98101, USA.|Departments of Epidemiology and Health Services, University of Washington, Seattle, Washington 98101, USA.|Group Health Research Institute, Group Health Cooperative, Seatte, Washington 98101, USA.
authors.forename: Bruce M
authors.initials: BM
authors.lastname: Psaty
authors.affiliation: South Ostrobothnia Central Hospital, Seinäjoki Fi-60220, Finland.
authors.forename: Hannu
authors.initials: H
authors.lastname: Puolijoki
authors.affiliation: Kuopio Research Institute of Exercise Medicine, 70100 Kuopio, Finland.|Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, 70211 Kuopio, Finland.
authors.forename: Rainer
authors.initials: R
authors.lastname: Rauramaa
authors.affiliation: Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, EH8 9AG Teviot Place, Edinburgh, Scotland.
authors.forename: Igor
authors.initials: I
authors.lastname: Rudan
authors.affiliation: Department of Health, National Institute for Health and Welfare (THL), FI-00271 Helsinki, Finland.
authors.forename: Veikko
authors.initials: V
authors.lastname: Salomaa
authors.affiliation: Medical Faculty Carl Gustav Carus, Department of Medicine III, University of Dresden, 01307 Dresden, Germany.|Paul Langerhans Institute Dresden, German Center for Diabetes Research (DZD), Dresden 01307, Germany.
authors.forename: Peter E H
authors.initials: PE
authors.lastname: Schwarz
authors.affiliation: Division of Endocrinology, Diabetes &Nutrition, Department of Medicine, Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.|Geriatric Research and Education Clinical Center, Vetrans Administration Medical Center, Baltimore, Maryland 21042, USA.
authors.forename: Alan R
authors.initials: AR
authors.lastname: Shudiner
authors.affiliation: Department of Psychiatry and EMGO Institute for Health and Care Research, VU University Medical Center, AJ Ernstraat 1887, 1081 HL Amsterdam, The Netherlands.
authors.forename: Jan H
authors.initials: JH
authors.lastname: Smit
authors.affiliation: Faculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, University of Copenhagen, 2100 Copenhagen, Denmark.|MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol BS82BN, UK.|Institute of Preventive Medicine, Bispebjerg and Frederiksberg Hospital, The Capital Region, 2000 Frederiksberg, Denmark.
authors.forename: Thorkild I A
authors.initials: TI
authors.lastname: Sørensen
authors.affiliation: Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.
authors.forename: Timothy D
authors.initials: TD
authors.lastname: Spector
authors.affiliation: deCODE Genetics, Amgen inc., 101 Reykjavik, Iceland.|Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland.
authors.forename: Kari
authors.initials: K
authors.lastname: Stefansson
authors.affiliation: University of Leipzig, IFB Adiposity Diseases, 04103 Leipzig, Germany.|Department of Medicine, University of Leipzig, 04103 Leipzig, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Stumvoll
authors.affiliation: Department of Kinesiology, Laval University, Québec, Québec, Canada G1V 0A6.
authors.forename: Angelo
authors.initials: A
authors.lastname: Tremblay
authors.affiliation: Diabetes Prevention Unit, National Institute for Health and Welfare, FI-00271 Helsinki, Finland.|Centre for Vascular Prevention, Danube-University Krems, 3500 Krems, Austria.|Diabetes Research Group, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
authors.forename: Jaakko
authors.initials: J
authors.lastname: Tuomilehto
authors.affiliation: Department of Epidemiology, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands.|Department of Internal Medicine, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands.
authors.forename: André G
authors.initials: AG
authors.lastname: Uitterlinden
authors.affiliation: Department of Public Health and Clinical Nutrition, University of Eastern Finland, 70211 Kuopio, Finland.|Research Unit, Kuopio University Hospital, 70029 Kuopio, Finland.
authors.forename: Matti
authors.initials: M
authors.lastname: Uusitupa
authors.affiliation: Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, 17475 Greifswald, Germany.|DZHK (German Centre for Cardiovascular Research), Partner Site Greifswald, 17475 Greifswald, Germany.
authors.forename: Uwe
authors.initials: U
authors.lastname: Völker
authors.affiliation: Department of Internal Medicine, University Hospital Lausanne (CHUV) and University of Lausanne, 1011 Lausanne, Switzerland.
authors.forename: Peter
authors.initials: P
authors.lastname: Vollenweider
authors.affiliation: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Wareham
authors.affiliation: Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK.|Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
authors.forename: Hugh
authors.initials: H
authors.lastname: Watkins
authors.affiliation: MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, EH4 2XU Edinburgh, Scotland.|Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, EH8 9AG Teviot Place, Edinburgh, Scotland.
authors.forename: James F
authors.initials: JF
authors.lastname: Wilson
authors.affiliation: Wellcome Trust Sanger Institute, Human Genetics, Hinxton, Cambridge CB10 1SA, UK.
authors.forename: Eleftheria
authors.initials: E
authors.lastname: Zeggini
authors.affiliation: Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA.
authors.forename: Goncalo R
authors.initials: GR
authors.lastname: Abecasis
authors.affiliation: Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Boehnke
authors.affiliation: Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri 63108, USA.
authors.forename: Ingrid B
authors.initials: IB
authors.lastname: Borecki
authors.affiliation: William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.|Wellcome Trust Sanger Institute, Human Genetics, Hinxton CB10 1HH, UK.|Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah 21589, Saudi Arabia.
authors.forename: Panos
authors.initials: P
authors.lastname: Deloukas
authors.affiliation: Department of Epidemiology, Genetic Epidemiology Unit, Erasmus University Medical Center, 3015GE Rotterdam, The Netherlands.|Center for Medical Systems Biology, 2300 Leiden, The Netherlands.
authors.forename: Cornelia M
authors.initials: CM
authors.lastname: van Duijn
authors.affiliation: National Heart, Lung, and Blood Institute, the Framingham Heart Study, Framingham, Massachusetts 01702, USA.|Harvard Medical School, Boston, Massachusetts, 02115, USA.
authors.forename: Caroline
authors.initials: C
authors.lastname: Fox
authors.affiliation: Lund University Diabetes Centre and Department of Clinical Science, Diabetes &Endocrinology Unit, Lund University, 221 00 Malmö, Sweden.|Finnish Institute for Molecular Medicine (FIMM), Helsinki University, 00014 Helsinki, Finland.
authors.forename: Leif C
authors.initials: LC
authors.lastname: Groop
authors.affiliation: Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, 93053 Regensburg, Germany.|Institute of Genetic Epidemiology, Helmholtz Zentrum München, Neuherberg 85764, Germany.
authors.forename: Iris M
authors.initials: IM
authors.lastname: Heid
authors.affiliation: Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 2142, USA.|Department of Medicine, Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.|Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA.|Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
authors.forename: David J
authors.initials: DJ
authors.lastname: Hunter
authors.affiliation: Department of Epidemiology and Popualtion Health, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
authors.forename: Robert C
authors.initials: RC
authors.lastname: Kaplan
authors.affiliation: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.|Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford OX3 7LJ, UK.|Oxford NIHR Biomedical Research Centre, Oxford OX3 7LJ, UK.
authors.forename: Mark I
authors.initials: MI
authors.lastname: McCarthy
authors.affiliation: Department of Epidemiology, Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7400, USA.
authors.forename: Kari E
authors.initials: KE
authors.lastname: North
authors.affiliation: Division of Endocrinology, Diabetes &Nutrition, Department of Medicine, Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.
authors.forename: Jeffrey R
authors.initials: JR
authors.lastname: O'Connell
authors.affiliation: National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA.
authors.forename: David
authors.initials: D
authors.lastname: Schlessinger
authors.affiliation: deCODE Genetics, Amgen inc., 101 Reykjavik, Iceland.|Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland.
authors.forename: Unnur
authors.initials: U
authors.lastname: Thorsteinsdottir
authors.affiliation: Population Health Research Institute, St George's, University of London, London SW17 0RE, UK.
authors.forename: David P
authors.identifier: 0000-0001-7854-1366
authors.initials: DP
authors.lastname: Strachan
authors.affiliation: Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, UK.
authors.forename: Timothy
authors.initials: T
authors.lastname: Frayling
authors.affiliation: Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 2142, USA.|Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts 02115, USA.|Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.|Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA.|Division of Endocrinology, Boston Children's Hospital, Boston, Massachusetts 02115, USA.|Divisions of Genetics and Endocrinology and Program in Genomics, Boston's Children's Hospital, Boston, Massachusetts 02115, USA.|Metabolism Initiative, Broad Institute, Cambridge, Massachusetts 02142, USA.
authors.forename: Joel N
authors.initials: JN
authors.lastname: Hirschhorn
authors.affiliation: Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany.|Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, 81377 Munich, Germany.|DZHK (German Centre for Cardiovascular Research), partnersite Munich Heart Alliance, 80802 Munich, Germany.|Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-Universität, 81377 Munich, Germany.
authors.forename: Martina
authors.initials: M
authors.lastname: Müller-Nurasyid
authors.affiliation: The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.|MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.|The Department of Preventive Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.|The Genetics of Obesity and Related Metabolic Traits Program, The Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.|The Mindich Child Health and Development Institute, The Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
authors.forename: Ruth J F
authors.initials: RJ
authors.lastname: Loos
mesh_terms: D000886:Anthropometry; D049628:Body Size; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008957:Models, Genetic; D025341:Principal Component Analysis