title: Ultra-high magnetic resonance imaging (MRI): a potential examination for deep brain stimulation devices and the limitation study concerning MRI-related heating injury.
abstract: Nowadays, the patients with deep brain stimulation (DBS) devices are restricted to undertake 1.5T magnetic resonance imaging (MRI) according to the guideline. Nevertheless, we conducted an experiment to test pathological change near the leads in different field-strength MRI. Twenty-four male New Zealand rabbits were assigned to Group 1 (G1, n = 6, 7.0T, DBS), Group 2 (G2, n = 6, 3.0T, DBS), Group 3 (G3, n = 6, 1.5T, DBS), and Group 4 (G4, n = 6, 1.5T, paracentesis). DBS leads were implanted in G1, G2 and G3, targeting left nucleus ventralis posterior thalami. Paracentesis was performed in G4. 24 h after MRI scan, all animals were killed for examining pathological alternation (at different distance from lead) via transmission electron microscopy. Our results suggest that the severity of tissue injury correlates with the distance to electrode instead of field strength of MRI. Up to now, the reason for the restriction of MRI indicated no significantly different pathological change.
authors.affiliation: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China.
authors.forename: Ying-Chuan
authors.initials: YC
authors.lastname: Chen
authors.affiliation: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China.|Department of Neurosurgery, People's Hospital of Hainan Province, Haikou, Hainan, China.
authors.forename: Jun-Ju
authors.initials: JJ
authors.lastname: Li
authors.affiliation: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China.
authors.forename: Guan-Yu
authors.initials: GY
authors.lastname: Zhu
authors.affiliation: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Shi
authors.affiliation: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China.
authors.forename: An-Chao
authors.initials: AC
authors.lastname: Yang
authors.affiliation: Department of Functional Neurosurgery, Beijing Neurosurgical Institute, Capital Medical University, Beijing, 100050, China.
authors.forename: Yin
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: Department of Functional Neurosurgery, Beijing Neurosurgical Institute, Capital Medical University, Beijing, 100050, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China. zjguo73@126.com.|Department of Functional Neurosurgery, Beijing Neurosurgical Institute, Capital Medical University, Beijing, 100050, China. zjguo73@126.com.|Beijing Key Laboratory of Neurostimulation, Beijing, 100050, China. zjguo73@126.com.
authors.forename: Jian-Guo
authors.initials: JG
authors.lastname: Zhang
mesh_terms: D000818:Animals; D001921:Brain / Q000473:pathology*; D046690:Deep Brain Stimulation; D004567:Electrodes, Implanted / Q000009:adverse effects; D006361:Heating; D008279:Magnetic Resonance Imaging / Q000009:adverse effects* / Q000379:methods*; D008297:Male; D023421:Models, Animal; D011817:Rabbits
keywords: Deep brain stimulation; Heating injury; Limitation; Magnetic resonance imaging