title: Synthesis and characterization of silver nanoparticles using Caesalpinia pulcherrima flower extract and assessment of their in vitro antimicrobial, antioxidant, cytotoxic, and genotoxic activities.
abstract: Caesalpinia pulcherrima flower extract mediated synthesis of silver nanoparticles was attempted in the present work including optimization of some procedure parameters. Characterization of synthesized silver nanoparticles was done by various spectral analyses. The size of synthesized silver nanoparticles was 12 nm and they were spherical in shape. The green synthesized silver nanoparticles were further evaluated for antimicrobial, antioxidant, cytotoxic, and genotoxic activities; they showed good antimicrobial, antioxidant, and cytotoxic effects. Genotoxic study revealed non-toxic nature at lower concentration. Overall results suggest that the synthesized silver nanoparticles have pronounced applicability in pharmaceutical and biomedical field.
authors.affiliation: a Department of Biosciences (UGC-CAS) , Saurashtra University , Rajkot , Gujarat , India.
authors.forename: Pooja
authors.initials: P
authors.lastname: Moteriya
authors.affiliation: a Department of Biosciences (UGC-CAS) , Saurashtra University , Rajkot , Gujarat , India.
authors.forename: Sumitra
authors.initials: S
authors.lastname: Chanda
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D029911:Caesalpinia / Q000737:chemistry*; D060326:Chemistry Techniques, Synthetic; D002869:Chromosome Aberrations / Q000187:drug effects; D035264:Flowers / Q000737:chemistry*; D055772:Green Chemistry Technology; D006367:HeLa Cells; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000187:drug effects; D053768:Metal Nanoparticles / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D009153:Mutagens / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D036103:Nanotechnology; D010316:Particle Size; D010936:Plant Extracts / Q000737:chemistry*; D012834:Silver / Q000737:chemistry* / Q000494:pharmacology* / Q000633:toxicity
chemical_list: D000890:Anti-Infective Agents; D000975:Antioxidants; D009153:Mutagens; D010936:Plant Extracts; D012834:Silver
keywords: Silver nanoparticles; antimicrobial activity; antioxidant activity; characterization; cytotoxicity; genotoxicity