title: In vitro and in vivo anthelmintic activity of seed extract ofCoriandrum sativumcompared to Niclosamid againstHymenolepis nanainfection.
abstract: Phytotherapy can be an alternative for the control of gastrointestinal parasites in human and animals. Coriander (Coriandrum sativumL.) is a medicinal plant which grown as a spice crop all over the world. The seeds of this plant have been used to treat parasitic disease, indigestion, diabetes, rheumatism and pain in the joints. This study was carried out to compare the efficacy of Niclosamid and alcoholic seed extract ofC. sativumonHymenolepis nanainfection, in vivo and vitro. For in vivo study, Balb/c mice were used, to compare the efficacy of 50 mg/kg body weight (B.W) of Niclosamid with different doses of alcoholic extracts ofC. sativum(250, 500, and 750 mg/kg B.W). It was found that the efficacy of Niclosamid had reached 100 % after 11 days post treatment, while the efficacy of 500 and 750 mg/kg B.W ofC. sativumreached to 100 % after 15 days after treatment. For in vitro study, special nutrient broth media was used. It was found that the addition of 1000 mg/ml of Niclosamid had paralyzed and killed worms within 5 min, whileC. sativumkilled them within 30 min. Our results showed that extract ofC. sativumhas good effect againstH. nanaand could be use in traditional medicine for treatment of parasitic disease.
authors.affiliation: Biosatistics Department, University of Welfare and Rehabilitation, Tehran, Iran.
authors.forename: Samaneh
authors.initials: S
authors.lastname: Hosseinzadeh
authors.affiliation: Biosatistics Department, University of Welfare and Rehabilitation, Tehran, Iran ; Division of Nursing, Shahid Modarres Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Maryam Jamshidian
authors.initials: MJ
authors.lastname: Ghalesefidi
authors.affiliation: Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical sciences, Isfahan, Iran.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Azami
authors.affiliation: Department of Parasitology and Mycology, School of Medicine, Isfahan University of Medical Science, Isfahan, Iran.
authors.forename: Mohammad Ali
authors.initials: MA
authors.lastname: Mohaghegh
authors.affiliation: Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical sciences, Isfahan, Iran ; Department of Parasitology and Mycology, School of Medicine, Isfahan University of Medical Science, Isfahan, Iran.
authors.forename: Seyed Hossein
authors.initials: SH
authors.lastname: Hejazi
authors.affiliation: Department of Parasitology and Mycology, School of Medicine, Isfahan University of Medical Science, Isfahan, Iran.
authors.forename: Mohsen
authors.initials: M
authors.lastname: Ghomashlooyan
keywords: Anthelmintic activity; Coriandrum sativum; Hymenolepis nana; Niclosamid