title: Chemical composition and antifungal activity of essential oils from medicinal plants of Kazakhstan.
abstract: The composition of essential oils from leaves of Kazakhstan medicinal plants was analysed by GC-MS. The major compounds identified were 1,8-cineole (34.2%), myrcene (19.1%) and α-pinene (9.4%) in Ajania fruticulosa; 1,8-cineole (21.0%), β-thujone (11.0%), camphor (8.5%), borneol (7.3%) and α-thujone (6.5%), in Achillea nobilis; camphor (47.3%), 1,8-cineole (23.9%), camphene (9.8%) and β-thujone (6.0%) in Artemisia terrae-albae; 1,8-cineole(55.8%) and β-pinene (6.2%) in Hyssopus ambiguus; α-thuyene(46.3%) and δ-cadinene(6.3%) in Juniperus sibirica; sabinene (64%) in Juniperus sabina; and α-pinene (51.5%), β-phellandrene (11.2%) and δ-cadinene (6.3%) in Pinus sibirica. The essential oils did not show antifungal effect (MIC > 1.20 mg/mL) on Aspergillus carbonarius and Aspergillus niger, while the oils from A. nobilis, A. terrae-albae, H. ambiguus and J. sabina exhibited moderate and moderate to weak antimicrobial activities on Fusarium verticillioides (MIC = 0.60 mg/mL) and Fusarium graminearum (MIC = 0.60-1.20 mg/mL), respectively. A principal component analysis associated the antifungal activity (r2> 0.80, p = 0.05) with the presence of borneol, camphor, camphene, 1,8-cineole,α- and β-thujone, and of the oxygenated monoterpenes.
authors.affiliation: a Laboratorio de Biología de Agentes Bioactivos y Fitopatógenos (LABIFITO) , Universidad Nacional de Tucumán , Tucuman , Argentina.
authors.forename: Diego A
authors.initials: DA
authors.lastname: Sampietro
authors.affiliation: a Laboratorio de Biología de Agentes Bioactivos y Fitopatógenos (LABIFITO) , Universidad Nacional de Tucumán , Tucuman , Argentina.
authors.forename: Analía de Los A
authors.initials: AL
authors.lastname: Gomez
authors.affiliation: a Laboratorio de Biología de Agentes Bioactivos y Fitopatógenos (LABIFITO) , Universidad Nacional de Tucumán , Tucuman , Argentina.
authors.forename: Cristina M
authors.initials: CM
authors.lastname: Jimenez
authors.affiliation: c Instituto de Fisiología Animal , Fundación Miguel Lillo , San Miguel de Tucumán , Argentina.
authors.forename: Emilio F
authors.initials: EF
authors.lastname: Lizarraga
authors.affiliation: d Institute of Applied Chemistry , L. N. Gumilev Eurasian National University , Astana , Republic of Kazakhstan.
authors.forename: Zharkyn A
authors.initials: ZA
authors.lastname: Ibatayev
authors.affiliation: d Institute of Applied Chemistry , L. N. Gumilev Eurasian National University , Astana , Republic of Kazakhstan.
authors.forename: Yerlan M
authors.initials: YM
authors.lastname: Suleimen
authors.affiliation: b Facultad de Bioquímica, Química y Farmacia, Instituto de Química del Noroeste Argentino (INQUINOA)-CONICET , Universidad Nacional de Tucumán , San Miguel de Tucumán , Argentina.
authors.forename: Cesar A
authors.initials: CA
authors.lastname: Catalán
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D007623:Kazakhstan; D009822:Oils, Volatile / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D025341:Principal Component Analysis
chemical_list: D000935:Antifungal Agents; D009822:Oils, Volatile
keywords: Antifungal activity; Aspergillus; Fusarium; essential oils; medicinal plants