title: New Technologies for Rapid Bacterial Identification and Antibiotic Resistance Profiling.
abstract: Conventional approaches to bacterial identification and drug susceptibility testing typically rely on culture-based approaches that take 2 to 7 days to return results. The long turnaround times contribute to the spread of infectious disease, negative patient outcomes, and the misuse of antibiotics that can contribute to antibiotic resistance. To provide new solutions enabling faster bacterial analysis, a variety of approaches are under development that leverage single-cell analysis, microfluidic concentration and detection strategies, and ultrasensitive readout mechanisms. This review discusses recent advances in this area and the potential of new technologies to enable more effective management of infectious disease.
authors.affiliation: 1 Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada.|2 Department of Chemistry, Faculty of Arts and Science, University of Toronto, Toronto, ON, Canada.|3 Institute for Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, Canada.|4 Department of Biochemistry, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
authors.forename: Shana O
authors.initials: SO
authors.lastname: Kelley
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000145:classification / Q000302:isolation & purification*; D001424:Bacterial Infections / Q000175:diagnosis*; D001431:Bacteriological Techniques / Q000379:methods* / Q000639:trends*; D006801:Humans; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents
keywords: clinical automation; lab-on-a-chip; microfluidics; microtechnology