title: IL28B SNP rs12979860 is the Critical Predictor for Sustained Viral Response in Chinese Children Aged 1 to 6 Years with Chronic Hepatitis C.
abstract: Clinical data on children with chronic hepatitis C (CHC) remain extremely limited. This study investigated sustained virologic response (SVR) to alfa-interferon 2b plus RBV treatment in children aged 1-6 years with unsafe injection-acquired CHC. 154 children with CHC aged 1 to 6 years were enrolled, 101 of them were male (65.6%) and 53 were female (34.4%), and they were treated with alfa-interferon at a dose of 1-5 MIU/m23 times weekly plus oral RBV (15 mg/kg/day) for 48 weeks. 57(39.3 %) of them were genotype 1b, 73(50.3%) were genotypes 2a, 15(10.3%) were undecided type. SVR was achieved in 53 of 57(93.0%) patients with genotype 1b, in 72 (98.6%) of 73 with genotype 2a, 15(100.0%) of 15 with undecided type. There was no significant statistical difference in SVR between male and female (98.0% vs 94.3%, p=0.340), genotype 2a and those with genotype 1b(98.6% vs 93.0%, p=0.160), ALT>40U/L group and ALT≤40U/L group(96.7% vs 96.8%, p=1.000), AST>40U/L group and AST≤40U/L group(95.9% vs 98.2%, p=0.654) as well as lower baseline viral load group (<6×105IU/ml) and higher baseline viral load group(≥6×105IU/ml)(97.3% vs 95.3%, p=0.916). Leucopenia, neutropenia, hemoglobin concentration decrease, fever, platelet count decrease and rash were 8.4%, 69.5%, 24.0%, 50.6%, 1.9% and 4.5%, respectively. And only 12(7.8%) individuals developed thyroid autoantibodies. The SVR was higher in patients with IL-28B genotype C/C than C/T (99.0% vs 80%, p=0.002). Compared with HCV viral genotype, ALT level and baseline viral load, IL-28B rs12979860 is more suitable for predicting antiviral efficacy in children with CHC. It is inappropriate to take the increase of ALT level as an essential indicator for antiviral treatment in children aged 1-6 years.
authors.affiliation: Institute of Infectious Diseases, pediatric liver disease therapy and research center, Xisihuan mid-road No.100, Beijing 302 Hospital, Beijing, China.
authors.forename: Yan-Wei
authors.initials: YW
authors.lastname: Zhong
authors.affiliation: Institute of Infectious Diseases, pediatric liver disease therapy and research center, Xisihuan mid-road No.100, Beijing 302 Hospital, Beijing, China.
authors.forename: Hong-Fei
authors.initials: HF
authors.lastname: Zhang
authors.affiliation: HeBei North University, Changqing road No.36, Zhangjiakou, China.
authors.forename: Yan-Min
authors.initials: YM
authors.lastname: Shi
authors.affiliation: Institute of Infectious Diseases, pediatric liver disease therapy and research center, Xisihuan mid-road No.100, Beijing 302 Hospital, Beijing, China.
authors.forename: Yong-Li
authors.initials: YL
authors.lastname: Li
authors.affiliation: Institute of Infectious Diseases, pediatric liver disease therapy and research center, Xisihuan mid-road No.100, Beijing 302 Hospital, Beijing, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Chu
authors.affiliation: Institute of Infectious Diseases, pediatric liver disease therapy and research center, Xisihuan mid-road No.100, Beijing 302 Hospital, Beijing, China.
authors.forename: Zhi-Qiang
authors.initials: ZQ
authors.lastname: Xu
authors.affiliation: Institute of Infectious Diseases, pediatric liver disease therapy and research center, Xisihuan mid-road No.100, Beijing 302 Hospital, Beijing, China.
authors.forename: Da-Wei
authors.initials: DW
authors.lastname: Chen
authors.affiliation: Institute of Infectious Diseases, pediatric liver disease therapy and research center, Xisihuan mid-road No.100, Beijing 302 Hospital, Beijing, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Gan
authors.affiliation: Institute of Infectious Diseases, pediatric liver disease therapy and research center, Xisihuan mid-road No.100, Beijing 302 Hospital, Beijing, China.
authors.forename: Fu-Chuan
authors.initials: FC
authors.lastname: Wang
authors.affiliation: Institute of Infectious Diseases, pediatric liver disease therapy and research center, Xisihuan mid-road No.100, Beijing 302 Hospital, Beijing, China.
authors.forename: Mei-Lei
authors.initials: ML
authors.lastname: Gu
authors.affiliation: Institute of Infectious Diseases, pediatric liver disease therapy and research center, Xisihuan mid-road No.100, Beijing 302 Hospital, Beijing, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Dong
authors.affiliation: Institute of Infectious Diseases, pediatric liver disease therapy and research center, Xisihuan mid-road No.100, Beijing 302 Hospital, Beijing, China.
authors.forename: Shi-Shu
authors.initials: SS
authors.lastname: Zhu
authors.affiliation: Institute of Infectious Diseases, pediatric liver disease therapy and research center, Xisihuan mid-road No.100, Beijing 302 Hospital, Beijing, China.
authors.forename: Ce
authors.initials: C
authors.lastname: Shi
authors.affiliation: Institute of Infectious Diseases, pediatric liver disease therapy and research center, Xisihuan mid-road No.100, Beijing 302 Hospital, Beijing, China.
authors.forename: Hua-Hao
authors.initials: HH
authors.lastname: Fan
authors.affiliation: HeBei North University, Changqing road No.36, Zhangjiakou, China.
authors.forename: Xiu-Chang
authors.initials: XC
authors.lastname: Zhang
authors.affiliation: Institute of Infectious Diseases, pediatric liver disease therapy and research center, Xisihuan mid-road No.100, Beijing 302 Hospital, Beijing, China.
authors.forename: Min
authors.initials: M
authors.lastname: Zhang
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D005260:Female; D005838:Genotype; D019698:Hepatitis C, Chronic / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology / Q000821:virology*; D006801:Humans; D007223:Infant; D016898:Interferon-alpha / Q000627:therapeutic use; D007372:Interferons; D007378:Interleukins / Q000235:genetics*; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D000072230:Sustained Virologic Response; D019562:Viral Load / Q000187:drug effects; D000095022:Interferon Lambda
chemical_list: D000998:Antiviral Agents; D016898:Interferon-alpha; D007372:Interferons; D007378:Interleukins; C000624353:interferon-lambda, human; D000095022:Interferon Lambda
keywords: IL-28B rs12979860; chronic hepatitis C