title: A Meta-analysis of MBL2 Polymorphisms and Tuberculosis Risk.
abstract: MBL2 gene encodes mannose-binding lectin, is a member of innate immune system. Earlier studies revealed that MBL2 gene variants, rs1800451, rs1800450, rs5030737, rs7096206, rs11003125 and rs7095891 are associated with impaired serum level and susceptibility to TB, but their results are inconsistent. A meta-analysis was performed by including 22 studies (7095 TB-patients and 7662 controls) and data were analyzed with respect to associations between alleles, genotypes and minor allele carriers to evaluate the potential association between MBL2 polymorphisms and TB risk. Statistically significant results were found only for the homozygous variant genotype (CC vs. AA: p = 0.045; OR = 0.834, 95% CI = 0.699 to 0.996) of rs1800451 and showed reduced risk of TB in overall population. However, other genetic models of rs1800450, rs5030737, rs7096206, rs11003125, rs7095891 and combined rs1800450, rs1800451, rs5030737 polymorphisms of MBL2 gene did not reveal any association with TB risk. Stratified analysis by ethnicity showed decreased risk of TB in African population for rs1800450 and rs1800451. Whereas, no association was observed between other MBL2 polymorphisms and TB risk in all the evaluated ethnic populations. In conclusion, MBL2 rs1800450 and rs1800451 polymorphisms play a protective role in TB infection and reinforce their critical significance as a potential genetic marker for TB resistance.
authors.affiliation: Research and Scientific Studies Unit, College of Nursing &Allied Health Sciences, Jazan University, Jazan-45142, Saudi Arabia.
authors.forename: Mohammed Y
authors.initials: MY
authors.lastname: Areeshi
authors.affiliation: Research and Scientific Studies Unit, College of Nursing &Allied Health Sciences, Jazan University, Jazan-45142, Saudi Arabia.
authors.forename: Raju K
authors.initials: RK
authors.lastname: Mandal
authors.affiliation: Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Albaha University, Albaha-65431, Saudi Arabia.
authors.forename: Naseem
authors.initials: N
authors.lastname: Akhter
authors.affiliation: Research and Scientific Studies Unit, College of Nursing &Allied Health Sciences, Jazan University, Jazan-45142, Saudi Arabia.|The University College of Medical Sciences &GTB Hospital (University of Delhi), Delhi-110095, India.
authors.forename: Sajad A
authors.initials: SA
authors.lastname: Dar
authors.affiliation: Research and Scientific Studies Unit, College of Nursing &Allied Health Sciences, Jazan University, Jazan-45142, Saudi Arabia.
authors.forename: Arshad
authors.initials: A
authors.lastname: Jawed
authors.affiliation: Research and Scientific Studies Unit, College of Nursing &Allied Health Sciences, Jazan University, Jazan-45142, Saudi Arabia.
authors.forename: Mohd
authors.initials: M
authors.lastname: Wahid
authors.affiliation: Centre for Life Sciences, Central University of Jharkhand, Ranchi-835205, Jharkhand, India.
authors.forename: Harishankar
authors.initials: H
authors.lastname: Mahto
authors.affiliation: Centre for Life Sciences, Central University of Jharkhand, Ranchi-835205, Jharkhand, India.
authors.forename: Aditya K
authors.initials: AK
authors.lastname: Panda
authors.affiliation: Research and Scientific Studies Unit, College of Nursing &Allied Health Sciences, Jazan University, Jazan-45142, Saudi Arabia.|Department of Biosciences, Integral University, Lucknow-226026, Uttar Pradesh, India.
authors.forename: Mohtashim
authors.initials: M
authors.lastname: Lohani
authors.affiliation: Research and Scientific Studies Unit, College of Nursing &Allied Health Sciences, Jazan University, Jazan-45142, Saudi Arabia.|Department of Biosciences, Faculty of Natural Sciences, Jamia Millia Islamia (A Central University), New Delhi-110025, India.
authors.forename: Shafiul
authors.initials: S
authors.lastname: Haque
mesh_terms: D000483:Alleles; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D037601:Mannose-Binding Lectin / Q000235:genetics*; D011110:Polymorphism, Genetic; D012307:Risk Factors; D014376:Tuberculosis / Q000453:epidemiology / Q000235:genetics*
chemical_list: C445619:MBL2 protein, human; D037601:Mannose-Binding Lectin