title: Small non-coding RNAs-based bone regulation and targeting therapeutic strategies.
abstract: Small non-coding RNAs, which are 20-25 nucleotide ribonucleic acids, have emerged as an important transformation in the biological evolution over almost three decades. microRNAs (miRNAs) and short interfering RNAs (siRNAs) are two significant categories of the small RNAs that exert important effects on bone endocrinology and skeletology. Therefore, clarifying the expression and function of these important molecules in bone endocrine physiology and pathology is of great significance for improving their potential therapeutic value for metabolism-associated bone diseases. In the present review, we highlight the recent advances made in understanding the function and molecular mechanism of these small non-coding RNAs in bone metabolism, especially their potentially therapeutic values in bone-related diseases.
authors.affiliation: Department of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai JiaoTong University, School of Medicine, Shanghai, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai JiaoTong University, School of Medicine, Shanghai, China. Electronic address: fangsijie89@hotmail.com.
authors.forename: Sijie
authors.initials: S
authors.lastname: Fang
mesh_terms: D051701:Activating Transcription Factor 4 / Q000235:genetics / Q000378:metabolism; D000818:Animals; D001859:Bone Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D001842:Bone and Bones / Q000378:metabolism / Q000473:pathology; D050659:Core Binding Factor Alpha 1 Subunit / Q000235:genetics / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism / Q000627:therapeutic use; D058990:Molecular Targeted Therapy / Q000379:methods*; D010003:Osteoarthritis / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D010006:Osteoblasts / Q000378:metabolism / Q000473:pathology; D010024:Osteoporosis / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D034741:RNA, Small Interfering / Q000235:genetics* / Q000378:metabolism / Q000627:therapeutic use; D015398:Signal Transduction; D000076182:Sp7 Transcription Factor / Q000235:genetics / Q000378:metabolism; D051176:beta Catenin / Q000235:genetics / Q000378:metabolism
chemical_list: C497109:ATF4 protein, human; C495270:CTNNB1 protein, human; D050659:Core Binding Factor Alpha 1 Subunit; D035683:MicroRNAs; D034741:RNA, Small Interfering; C493709:RUNX2 protein, human; D000076182:Sp7 Transcription Factor; C478163:SP7 protein, human; D051176:beta Catenin; D051701:Activating Transcription Factor 4
keywords: Bone metabolism; Targeting therapeutics; miRNA; siRNA