title: A prediction and simulation model for target-oriented regional citrate-calcium anticoagulation in extracorporeal blood purification.
abstract: OBJECTIVE
  Regional citrate-calcium anticoagulation is becoming more and more attractive for extracorporeal treatments in the clinical routine.
  
  
  METHODS
  A prediction and simulation tool for the safe application of RCA during extracorporeal treatments was introduced. The model predicts the course of the ionized calcium level in the patient and the current anticoagulation status in the extracorporeal circuit based on the actual settings of the dialysis machine.
  
  
  RESULTS
  The simulation tool delivers areas in which the blood and dialysate flow can be adjusted to reach the desired target values for RCA and predicts the time course of several parameters during treatment.
authors.affiliation: Center for Integrated Sensor Systems, Danube University Krems, Krems - Austria.
authors.forename: Martin
authors.initials: M
authors.lastname: Brandl
authors.affiliation: Center for Integrated Sensor Systems, Danube University Krems, Krems - Austria.
authors.forename: Karlheinz
authors.initials: K
authors.lastname: Kellner
mesh_terms: D000368:Aged; D000465:Algorithms; D000925:Anticoagulants / Q000494:pharmacology*; D002118:Calcium / Q000494:pharmacology*; D019343:Citric Acid / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D006435:Renal Dialysis
chemical_list: D000925:Anticoagulants; D019343:Citric Acid; D002118:Calcium