title: High flow oxygen therapy in adult critically ill patients.
abstract: High flow oxygen therapy is characterized for its ability to meet or exceed the high peak inspiratory flow of the patients with acute respiratory failure. Despite the lack of definitive evidence regarding its efficacy in improving clinically significant outcomes, its application has been rapidly spreading over the last decade. In this review we discuss the potential physiologic mechanisms of benefit as well as the most recent clinical trials investigating its role in adult critically ill patient.
authors.affiliation: Interdepartmental Division of Critical Care Medicine, University Health Network, University of Toronto, Toronto, ON, Canada - lorenzo.delsorbo@utoronto.ca.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Del Sorbo
authors.affiliation: Interdepartmental Division of Critical Care Medicine, University Health Network, University of Toronto, Toronto, ON, Canada.
authors.forename: Alice
authors.initials: A
authors.lastname: Vendramin
authors.affiliation: Department of Medicine, Mount Sinai Hospital, and Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada.
authors.forename: Sangeeta
authors.initials: S
authors.lastname: Mehta
mesh_terms: D000328:Adult; D003422:Critical Care / Q000379:methods*; D016638:Critical Illness / Q000628:therapy*; D006801:Humans; D010102:Oxygen Inhalation Therapy / Q000379:methods*; D012128:Respiratory Distress Syndrome / Q000628:therapy; D012131:Respiratory Insufficiency / Q000628:therapy*