title: Systematic Review and Meta-Analysis of Preoperative Risk Factors of Type II Endoleaks after Endovascular Aneurysm Repair.
abstract: BACKGROUND
  Type II endoleaks (T2Es) remain the Achilles heel of endovascular aneurysm repair (EVAR), involving a close follow-up and sometimes leading to reintervention. Identifying risk factors impacting T2Es is of concern to improve decision making and optimize follow-up. However, it has led to contradictory results, with supporting evidence for the majority of factors being weak.
  
  
  METHODS
  A systematic review and meta-analysis was conducted to study risk factors of T2Es following EVAR to identify risk factors and measure their dedicated strength of association. Using a literature search of MEDLINE, EMBASE, and the Cochrane Library, 31 retrospective studies including a total of 15,793 patients were identified and fulfilled the strict specified inclusion criteria. Random-effects meta-analysis was conducted for each factor to combine effect estimate across studies. A total of 21 factors related to demography, preoperative treatment, comorbidity, and morphology were statistically pooled.
  
  
  RESULTS
  On the basis of the pooled odds ratios and their 95% confidence intervals, patency of aortic side branches, represented by the patency of the inferior mesenteric artery, lumbar arteries, or total number of aortic side branches, were found to be significant harmful risk factors of T2Es. Women were also found to have nearly significant higher risk of developing T2Es than men. On the contrary, the following were found to have a significant protective role: smoking, peripheral artery disease, and thrombus load, represented by the maximum thickness at the maximum aneurysm diameter, the presence of circumferential thrombus, or the presence of thrombus at the level of inferior mesenteric artery.
  
  
  CONCLUSIONS
  Identifying significant risk factors of development of T2Es is mandatory to improve decision making and optimize surveillance planning in EVAR.
authors.affiliation: Therenva, Rennes, France.
authors.forename: Florent
authors.initials: F
authors.lastname: Lalys
authors.affiliation: Therenva, Rennes, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Durrmann
authors.affiliation: Therenva, Rennes, France; INSERM, U1099, Rennes, France; University Rennes 1, Signal and Image Processing Laboratory (LTSI), Rennes, France.
authors.forename: Aurélien
authors.initials: A
authors.lastname: Duménil
authors.affiliation: Therenva, Rennes, France.
authors.forename: Cemil
authors.initials: C
authors.lastname: Göksu
authors.affiliation: Department of Cardiothoracic and Vascular Surgery, CHU Rennes, Rennes, France.
authors.forename: Alain
authors.initials: A
authors.lastname: Cardon
authors.affiliation: Department of Cardiothoracic and Vascular Surgery, CHU Rennes, Rennes, France.
authors.forename: Elodie
authors.initials: E
authors.lastname: Clochard
authors.affiliation: INSERM, U1099, Rennes, France; University Rennes 1, Signal and Image Processing Laboratory (LTSI), Rennes, France; Department of Cardiothoracic and Vascular Surgery, CHU Rennes, Rennes, France.
authors.forename: Antoine
authors.initials: A
authors.lastname: Lucas
authors.affiliation: INSERM, U1099, Rennes, France; University Rennes 1, Signal and Image Processing Laboratory (LTSI), Rennes, France; Department of Cardiothoracic and Vascular Surgery, CHU Rennes, Rennes, France. Electronic address: kaladrien@hotmail.fr.
authors.forename: Adrien
authors.initials: A
authors.lastname: Kaladji
mesh_terms: D017544:Aortic Aneurysm, Abdominal / Q000503:physiopathology / Q000601:surgery*; D019917:Blood Vessel Prosthesis Implantation / Q000009:adverse effects*; D057867:Endoleak / Q000209:etiology* / Q000503:physiopathology; D057510:Endovascular Procedures / Q000009:adverse effects*; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D016017:Odds Ratio; D018570:Risk Assessment; D012307:Risk Factors; D016896:Treatment Outcome