title: Discriminating between neuropathic pain and sensory hypersensitivity using the Chronic Pain Questions (CPQ).
abstract: OBJECTIVE
  The Chronic Pain Questions (CPQ) were developed for clinical use with the aim of supporting primary care physicians in the screening, assessment and monitoring of patients with chronic pain. the purpose of this study was to examine the ability of the cpq CPQ to discriminate between patients with neuropathic pain (nep) versus those with sensory hypersensitivity (sh).
  
  
  METHODS
  Adult men and women with a diagnosis of a NeP or SH condition were recruited from 5 clinical sites across the United States. Participants completed a series of self-administered questionnaires, including the CPQ. Continuous variables were compared between groups with independent t-tests; categorical variables were compared with chi-square analyses. A series of exploratory logistic regressions were performed to discern optimal screening criteria for SH using CPQ responses.
  
  
  RESULTS
  98 participants, 68 with physician-confirmed diagnoses of SH and 30 with NeP, participated. 81.6% were female, 73.5% Caucasian, and mean (± SD) age was 58.4 ± 12.6 years. SH participants included significantly more females compared to the NeP group (94.1% vs. 53.3%). Differences in CPQ responses between groups were statistically significant for six of the 14 CPQ items with SH participants having significantly lower scores on specific pain quality questions and significantly higher scores on trouble thinking/remembering (5.3 ± 3.5 vs. 3.0 ± 2.8) and sensitivity to lights/noises/smells (4.8 ± 3.5 vs. 2.7 ± 3.0). No significant differences were found between groups for chronic pain intensity, pain made worse with touch, pain limited to joints, or pain interference with usual activity, sleep or mood. Logistic regression analyses revealed strong c indices (≥0.89) for all models. Consistent findings demonstrated that younger age, female gender, and scores ≥6 for the CPQ question on sensitivity to lights/noises/smells were all predictive of SH.
  
  
  CONCLUSIONS
  The CPQ can help differentiate between patients with NeP and SH. More research is warranted.
authors.affiliation: a Outcomes Research, Evidera , Bethesda , MD , USA.
authors.forename: Karin S
authors.initials: KS
authors.lastname: Coyne
authors.affiliation: a Outcomes Research, Evidera , Bethesda , MD , USA.
authors.forename: Brooke M
authors.initials: BM
authors.lastname: Currie
authors.affiliation: b Global Medical Affairs, Pfizer Inc , New York , NY , USA.
authors.forename: Sean
authors.initials: S
authors.lastname: Donevan
authors.affiliation: c Global Research & Development , Pfizer Inc , Groton , CT , USA.
authors.forename: Joseph C
authors.initials: JC
authors.lastname: Cappelleri
authors.affiliation: d North America Medical Affairs, Pfizer Inc , New York , NY , USA.
authors.forename: Rozelle
authors.initials: R
authors.lastname: Hegeman-Dingle
authors.affiliation: e Outcomes & Evidence, Global Health & Value, Pfizer Ltd , Tadworth , UK.
authors.forename: Lucy
authors.initials: L
authors.lastname: Abraham
authors.affiliation: a Outcomes Research, Evidera , Bethesda , MD , USA.
authors.forename: Christine
authors.initials: C
authors.lastname: Thompson
authors.affiliation: f Global Health & Value, Pfizer Inc , New York , NY , USA.
authors.forename: Alesia
authors.initials: A
authors.lastname: Sadosky
authors.affiliation: b Global Medical Affairs, Pfizer Inc , New York , NY , USA.
authors.forename: Marina
authors.initials: M
authors.lastname: Brodsky
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D059350:Chronic Pain / Q000175:diagnosis*; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D009437:Neuralgia / Q000175:diagnosis*; D011237:Predictive Value of Tests; D011594:Psychometrics; D012737:Sex Factors; D011795:Surveys and Questionnaires; D014481:United States
keywords: CPQ; chronic pain; neuropathic; psychometric; sensory hypersensitivity; validity