title: Peripartum maternal transmission of extended-spectrum β-lactamase organism to newborn infants.
abstract: The aim of this study was to determine whether the route of extended-spectrum β-lactamase (ESBL) transmission to hospitalized newborns was from their mothers during delivery. Neonatal intensive care unit (NICU) hospitalized newborns were sampled for ESBL presence by stool cultures on the first and fourth days of life. Mothers of ESBL-positive newborns were sampled for possible correlation detection. Bacteria isolates were molecularly identified and susceptibility tests for antibiotic agents were performed. Of the 225 newborns, 14 (6.2%) were ESBL positive, 10 (4.4%) were Escherichia coli positive, and 4 (1.7%) were Klebsiella pneumoniae positive. Among the 14 mothers of positive newborns, 13 (92.8%) were found ESBL positive and one mother of a newborn with E. coli carriage was found ESBL negative. Genes encoding for ESBL resistance were identified. Antibiotic sensitivity and resistance were tested. This study demonstrated that ESBL bacteria carrier neonates hospitalized in NICU may be a result of transmission from mother to baby during delivery.
authors.affiliation: Clinical Microbiology Laboratory, The Baruch Padeh Medical Center Poriya, Tiberias, Israel; The Faculty of Medicine in the Galilee, Bar Ilan University, Zefat, Israel. Electronic address: aperetz@poria.health.gov.il.
authors.forename: Avi
authors.initials: A
authors.lastname: Peretz
authors.affiliation: The Faculty of Medicine in the Galilee, Bar Ilan University, Zefat, Israel.
authors.forename: Alina
authors.initials: A
authors.lastname: Skuratovsky
authors.affiliation: Division of Epidemiology, Sourasky Medical Center, Tel Aviv, Israel.
authors.forename: Efrat
authors.initials: E
authors.lastname: Khabra
authors.affiliation: Division of Epidemiology, Sourasky Medical Center, Tel Aviv, Israel.
authors.forename: Amos
authors.initials: A
authors.lastname: Adler
authors.affiliation: Clinical Microbiology Laboratory, The Baruch Padeh Medical Center Poriya, Tiberias, Israel.
authors.forename: Nina
authors.initials: N
authors.lastname: Pastukh
authors.affiliation: The Faculty of Medicine in the Galilee, Bar Ilan University, Zefat, Israel; Department of Neonatology and Neonatal Intensive Care Unit, The Baruch Padeh Medical Center Poriya, Tiberias, Israel.
authors.forename: Shay
authors.initials: S
authors.lastname: Barak
authors.affiliation: The Faculty of Medicine in the Galilee, Bar Ilan University, Zefat, Israel; Department of Obstetrics and Gynecology, The Baruch Padeh Medical Center Poriya, Tiberias, Israel.
authors.forename: Yuri
authors.initials: Y
authors.lastname: Perlitz
authors.affiliation: The Faculty of Medicine in the Galilee, Bar Ilan University, Zefat, Israel; Department of Obstetrics and Gynecology, The Baruch Padeh Medical Center Poriya, Tiberias, Israel.
authors.forename: Moshe
authors.initials: M
authors.lastname: Ben-Ami
authors.affiliation: The Faculty of Medicine in the Galilee, Bar Ilan University, Zefat, Israel; Department of Neonatology and Neonatal Intensive Care Unit, The Baruch Padeh Medical Center Poriya, Tiberias, Israel.
authors.forename: Amir
authors.initials: A
authors.lastname: Kushnir
mesh_terms: D000293:Adolescent; D000328:Adult; D002353:Carrier State / Q000382:microbiology / Q000635:transmission*; D004756:Enterobacteriaceae Infections / Q000382:microbiology / Q000635:transmission*; D004926:Escherichia coli / Q000201:enzymology* / Q000302:isolation & purification; D005243:Feces / Q000382:microbiology; D005260:Female; D005838:Genotype; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D007711:Klebsiella pneumoniae / Q000201:enzymology* / Q000302:isolation & purification; D008297:Male; D008826:Microbial Sensitivity Tests; D058889:Molecular Typing; D058725:Peripartum Period; D010641:Phenotype; D055815:Young Adult; D001618:beta-Lactamases / Q000378:metabolism*
chemical_list: D001618:beta-Lactamases
keywords: E. coli; ESBL; K. pneumoniae; Neonatal intensive care units; Newborn