title: A lncRNA Perspective into (Re)Building the Heart.
abstract: Our conception of the human genome, long focused on the 2% that codes for proteins, has profoundly changed since its first draft assembly in 2001. Since then, an unanticipatedly expansive functionality and convolution has been attributed to the majority of the genome that is transcribed in a cell-type/context-specific manner into transcripts with no apparent protein coding ability. While the majority of these transcripts, currently annotated as long non-coding RNAs (lncRNAs), are functionally uncharacterized, their prominent role in embryonic development and tissue homeostasis, especially in the context of the heart, is emerging. In this review, we summarize and discuss the latest advances in understanding the relevance of lncRNAs in (re)building the heart.
authors.affiliation: Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases, University of CologneCologne, Germany; Institute for Neurophysiology, University of CologneCologne, Germany; Center for Molecular Medicine (CMMC), University of CologneCologne, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Frank
authors.affiliation: Division of Cardiovascular Medicine, Department of Medicine, University of California San Diego La Jolla, CA, USA.
authors.forename: Aitor
authors.initials: A
authors.lastname: Aguirre
authors.affiliation: Institute for Neurophysiology, University of Cologne Cologne, Germany.
authors.forename: Juergen
authors.initials: J
authors.lastname: Hescheler
authors.affiliation: Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases, University of CologneCologne, Germany; Institute for Neurophysiology, University of CologneCologne, Germany; Center for Molecular Medicine (CMMC), University of CologneCologne, Germany.
authors.forename: Leo
authors.initials: L
authors.lastname: Kurian
keywords: cardiac development; cardiac regeneration; cell-fate commitment; embryonic development; homeostasis; long non-coding RNAs