title: Metabolomics Reveals that Momordica charantia Attenuates Metabolic Changes in Experimental Obesity.
abstract: Momordica charantia L., also known as bitter melon, has been shown to ameliorate obesity and insulin resistance. However, metabolic changes regulated by M. charantia in obesity are not clearly understood. In this study, serums obtained from obese and M. charantia-treated mice were analyzed by using gas and liquid chromatography-mass spectrometry, and multivariate statistical analysis was performed by Orthogonal partial least squares discriminant analysis. The results from this study indicated that body weight fat and insulin levels of obese mice are dramatically suppressed by 8 weeks of dietary supplementation of M. charantia. Metabolomic data revealed that overproductions of energy and nutrient metabolism in obese mice were restored by M. charantia treatment. The antiinflammatory and inhibition of insulin resistance effect of M. charantia in obesity was illustrated with the restoration of free fatty acids and eicosanoids. The findings achieved in this study further strengthen the therapeutic value of using M. charantia to treat obesity. Copyright © 2016 John Wiley & Sons, Ltd.
authors.affiliation: Key Lab of Training, Monitoring and Intervention of Aquatic Sports of General Administration of Sport of China, Faculty of Physical Education, Jiangxi Normal University, Nanchang, China.
authors.forename: Zhi-Gang
authors.initials: ZG
authors.lastname: Gong
authors.affiliation: Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
authors.forename: Jianbing
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.|Department of Medicine, University of California San Diego, La Jolla, CA, USA.
authors.forename: Yong-Jiang
authors.initials: YJ
authors.lastname: Xu
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects*; D000818:Animals; D055432:Metabolomics / Q000379:methods*; D051379:Mice; D029777:Momordica charantia / Q000737:chemistry*; D009765:Obesity / Q000188:drug therapy*; D010936:Plant Extracts / Q000494:pharmacology*
chemical_list: D010936:Plant Extracts
keywords: Momordica charantia L; bitter melon; foodomics; metabolomics; obesity