title: Synthesis and Evaluation of the Hypoglycemic and Hypolipidemic Activity of Sulfonamide-benzothiazole Derivatives of Benzylidene-2,4- thiazolidnedione.
abstract: BACKGROUND
  Thiazolidinediones (TZDs) and sulfonamides are important and highly consumption class of antidiabetic drugs having insulin sensitizing and stimulating properties in patients with type 2 diabetes, respectively.
  
  
  OBJECTIVE
  In this paper, some novel benzothiazole derivatives of TZD-sulfonamides were synthesized (I-IV) and evaluated for anti-hyperglycemic and anti-hyperlipidemic activities in the STZ-induced diabetic rat model.
  
  
  RESULTS
  Results indicated that all new conjugated compounds showed significant hypoglycemic activities compared to control animals that were better for I and IV than others. Moreover, these new compounds displayed high efficiency for lowering lipid profiles as compared to control and standard (Pioglitazone) groups that was significant and higher for I than others.
  
  
  CONCLUSIONS
  It is concluded that these new conjugated TZD-sulfonamide-benzothiazoles (I-IV) can indicate useful results for hypoglycemic and hypolipidemic activities compared to control and standard groups, respectively with different mechanism that is closer to TZDs' analogs.
authors.affiliation: Department of Medicinal Chemistry, Pharmaceutical Sciences Branch, Islamic Azad University, No 99, Yakhchal, Gholhak, Shariati, Tehran, Iran.
authors.forename: Abbas
authors.initials: A
authors.lastname: Ahmadi
authors.affiliation: Neurophysiology Research Center, Shahed University, Tehran, Iran.
authors.forename: Mohsen
authors.initials: M
authors.lastname: Khalili
authors.affiliation: Department of Chemistry, Faculty of Science, Karaj Branch, Islamic Azad University, Karaj, Iran.
authors.forename: Lida
authors.initials: L
authors.lastname: Sohrabi
authors.affiliation: Department of Chemistry, Faculty of Science, Karaj Branch, Islamic Azad University, Karaj, Iran.
authors.forename: Nazanin
authors.initials: N
authors.lastname: Delzendeh
authors.affiliation: Department of Medicinal Chemistry, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran.
authors.forename: Babak
authors.initials: B
authors.lastname: Nahri-Niknafs
authors.affiliation: Department of Physiology, School of Medicine, Shahed University, Tehran, Iran.
authors.forename: Fariba
authors.initials: F
authors.lastname: Ansari
mesh_terms: D000818:Animals; D052160:Benzothiazoles / Q000737:chemistry / Q000627:therapeutic use*; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000188:drug therapy*; D007004:Hypoglycemic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use*; D015394:Molecular Structure; D051381:Rats; D013311:Streptozocin; D013449:Sulfonamides / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use*; D045162:Thiazolidinediones / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use*
chemical_list: D052160:Benzothiazoles; D007004:Hypoglycemic Agents; D013449:Sulfonamides; D045162:Thiazolidinediones; D013311:Streptozocin; C089946:2,4-thiazolidinedione; C005465:benzothiazole
keywords: Hypoglycemic and hypolipidemic activities; STZ-induced diabetic rat model; Sulfonamide-benzothiazole
  Derivatives; Thiazolidinediones (TZDs)