title: Efficacy of Danlou Tabletin Patients with Non-ST Elevation Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention: Results from a Multicentre, Placebo-Controlled, Randomized Trial.
abstract: This study seeks to investigate potential cardioprotection of Danlou Tablets in patients undergoing PCI with non-ST elevation acute coronary syndrome (NSTE-ACS). 219 patients with NSTE-ACS were randomised to Danlou Tablet pretreatment (n= 109) or placebo (n= 110). No patients received statins prior to PCI and all patients were given atorvastatin (10 mg/day) after procedure. The main endpoint was the composite incidence of major adverse cardiac events (MACEs) within 30 days after PCI. The proportion of patients with elevated levels of cTn I>5 × 99% of upper reference limit was significantly lower in the Danlou Tablet group at 8 h (22.0% versus 34.5%,p= 0.04) and 24 h (23.9% versus 38.2%,p= 0.02) after PCI. The 30-day MACEs occurred in 22.0% of the Danlou Tablet group and 33.6% in the placebo group (p= 0.06). The incidence of MACE at 90-day follow-up was significantly decreased in the Danlou Tablet group compared to the placebo group (23.9% versus 37.3%,p= 0.03). The difference between the groups at 90 days was the incidence of nonfatal myocardial infarction (22% versus 34.5%,p= 0.04). These findings might support that treatment with Danlou Tablet could reduce the incidence of periprocedural myocardial infarction in patients with ACS undergoing PCI.
authors.affiliation: Department of Critical Care Medicine, 2nd Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510120, China; Chest Pain Center, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510120, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Critical Care Medicine, 2nd Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510120, China; Chest Pain Center, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510120, China.
authors.forename: Xujie
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Department of Critical Care Medicine, 2nd Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510120, China; Chest Pain Center, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510120, China.
authors.forename: Shuai
authors.initials: S
authors.lastname: Mao
authors.affiliation: China-Australia International Research Centre for Chinese Medicine (CAIRC-CM), Guangdong Provincial Academy of Traditional Chinese Medicine, Guangzhou 510120, China.
authors.forename: Shaonan
authors.identifier: 0000-0003-4618-5779
authors.initials: S
authors.lastname: Liu
authors.affiliation: China-Australia International Research Centre for Chinese Medicine (CAIRC-CM), Guangdong Provincial Academy of Traditional Chinese Medicine, Guangzhou 510120, China.
authors.forename: Xinfeng
authors.identifier: 0000-0003-2699-9740
authors.initials: X
authors.lastname: Guo
authors.affiliation: Department of Critical Care Medicine, 2nd Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510120, China; Chest Pain Center, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510120, China.
authors.forename: Liheng
authors.initials: L
authors.lastname: Guo
authors.affiliation: Department of Cardiovascular Medicine, First Affiliated Hospital of Henan College of TCM, Zhengzhou 450004, China.
authors.forename: Tinghai
authors.initials: T
authors.lastname: Du
authors.affiliation: Department of Cardiovascular Medicine, Wuyi Hospital of TCM of Jiangmen City, Jiangmen 529000, China.
authors.forename: Haiyu
authors.initials: H
authors.lastname: Yang
authors.affiliation: Department of Cardiology, Xiyuan Hospital, Chinese Academy of Traditional Chinese Medicine, Beijing 100091, China.
authors.forename: Fuhai
authors.initials: F
authors.lastname: Zhao
authors.affiliation: Department of Cardiology, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524023, China.
authors.forename: Keng
authors.initials: K
authors.lastname: Wu
authors.affiliation: Department of Cardiology, Tianjin Chest Hospital, Tianjin 300051, China.
authors.forename: Hongliang
authors.initials: H
authors.lastname: Cong
authors.affiliation: Department of Cardiovascular Medicine, Oriental Hospital, Beijing University of Traditional Chinese Medicine, Beijing 100078, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Department of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
authors.forename: Phillip C
authors.identifier: 0000-0002-6274-895X
authors.initials: PC
authors.lastname: Yang
authors.affiliation: Department of Cardiology, Xiyuan Hospital, Chinese Academy of Traditional Chinese Medicine, Beijing 100091, China.
authors.forename: Keji
authors.initials: K
authors.lastname: Chen
authors.affiliation: Department of Critical Care Medicine, 2nd Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510120, China; Chest Pain Center, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510120, China.
authors.forename: Minzhou
authors.identifier: 0000-0002-5657-7891
authors.initials: M
authors.lastname: Zhang