title: FAT4 functions as a tumor suppressor in triple-negative breast cancer.
abstract: Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer that is often associated with biologic behavior with frequent distant metastasis. FAT tumor suppressor homolog 4 (FAT4), a cadherin-related protein, is involved in a variety of biological processes as a tumor suppressor; however, the role of FAT4 in TNBC is still unclear. The aim of our study was to identify the role of FAT4 in TNBC and examine the underlying molecular mechanisms. The expression of FAT4 was evaluated by immunohistochemistry, western blotting, and qRT-PCR in a series of TNBC tissues. The effects of FAT4 on the ability of cell proliferation, migration, and invasion were assessed by MTT assay and migration and invasion assays. We demonstrated that the repression of FAT4 by shRNA could promote TNBC progression. Taken together, our findings provide evidence for a role of the FAT4 cluster as a tumor suppressor in TNBC patients and may serve as potential novel targets for the treatment of TNBC.
authors.affiliation: Breast Disease Center, Southwest Hospital, Third Military Medical University, Chongqing, 40038, China.|Department of Thyroid Breast Surgery, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, 637000, China.|Institute of Hepatobiliary Pancreatic-Intestinal Diseases, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, 637000, China.
authors.forename: Lingmi
authors.initials: L
authors.lastname: Hou
authors.affiliation: Department of Breast and Thyroid Surgery, Suining Central Hospital, Suining, Sichuan, 629000, China.
authors.forename: Maoshan
authors.initials: M
authors.lastname: Chen
authors.affiliation: Department of Thyroid Breast Surgery, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, 637000, China.
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Institute of Hepatobiliary Pancreatic-Intestinal Diseases, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, 637000, China.
authors.forename: Jingdong
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Anatomy, The North Sichuan Medical College, Nanchong, Sichuan, 637000, China.
authors.forename: Shishan
authors.initials: S
authors.lastname: Deng
authors.affiliation: Department of Radiology, Wayne State University, Detroit, MI, 48331, USA.
authors.forename: Jiani
authors.initials: J
authors.lastname: Hu
authors.affiliation: Department of Breast and Thyroid Surgery, Suining Central Hospital, Suining, Sichuan, 629000, China. snhongweiyang@126.com.
authors.forename: Hongwei
authors.initials: H
authors.lastname: Yang
authors.affiliation: Breast Disease Center, Southwest Hospital, Third Military Medical University, Chongqing, 40038, China. southwestbreast@163.com.
authors.forename: Jun
authors.initials: J
authors.lastname: Jiang
keywords: FAT4; Invasion; Proliferation; TNBC