title: ERCC1andXRCC1but notXPAsingle nucleotide polymorphisms correlate with response to chemotherapy in endometrial carcinoma.
abstract: Our study aimed to investigate the correlation between single nucleotide polymorphisms ofERCC1/XRCC1/XPAgenes and postoperative chemotherapy efficacy and prognosis of endometrial carcinoma. Our study included 108 patients with endometrial carcinoma and 100 healthy participants.ERCC1rs11615/XRCC1rs25487/XPArs1800975 gene polymorphisms were detected by polymerase chain reaction-restriction fragment length polymorphism. Then the chemotherapy efficacy and toxic effects of the patients were assessed. The genotype and allele frequency ofERCC1rs11615/XRCC1rs25487 in the case group were significantly different from that in the control group (allP<0.05). The patients with AA + GA inERCC1rs11615 had an increased risk of endometrial carcinoma than those with GG, and the risk of endometrial carcinoma for patients with AA + GA was also higher in comparison with patients with GG genotype inXRCC1rs25487 (allP<0.05). GG on bothERCC1rs11615/XRCC1rs25487 had a higher effective rate of chemotherapy than GA + AA (allP<0.05).ERCC1rs11615/XRCC1rs25487 gene polymorphisms were linked with toxic effects in liver, kidney, and nervous system.ERCC1rs11615/XRCC1rs25487, muscular invasion, and tumor stage were independent risk factors for the prognosis of endometrial carcinoma (allP<0.05). However, no significant associations were observed betweenXPArs1800975 polymorphism and chemotherapy efficacy and prognosis of endometrial carcinoma (allP>0.05). These results indicated thatERCC1andXRCC1but notXPApolymorphisms correlate with response to chemotherapy in endometrial carcinoma.
authors.affiliation: Department of Gynecology and Obstetrics.
authors.forename: Liang
authors.initials: L
authors.lastname: Chen
authors.affiliation: Department of Gynecology and Obstetrics.
authors.forename: Mei-Mei
authors.initials: MM
authors.lastname: Liu
authors.affiliation: Department of Gynecology and Obstetrics.
authors.forename: Hui
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Oncology.
authors.forename: Dan
authors.initials: D
authors.lastname: Lu
authors.affiliation: Department of Clinical Laboratory, The 2nd Affiliated Hospital, Harbin Medical University.
authors.forename: Xiao-Dan
authors.initials: XD
authors.lastname: Zhao
authors.affiliation: Nursing Department, Harbin Chest Hospital, Harbin, People's Republic of China.
authors.forename: Xue-Jing
authors.initials: XJ
authors.lastname: Yang
keywords: ERCC1; XPA; XRCC1; chemotherapy; efficacy; endometrial carcinoma; single nucleotide polymorphism; toxic effects