title: Association of Thyroid Profile and Prolactin Level in Patient with Secondary Amenorrhea.
abstract: BACKGROUND
  Amenorrhea is the absence of menstrual periods. It has multiple social consequences as it may leads to infertility. This case control study was conducted for determining the association of thyroid hormones with hyperprolactinemia in patient with amenorrhea.
  
  
  METHODS
  We investigated 50 women with diagnosed cases of secondary amenorrhoea, who attended UCMS hospital, for hormonal evaluations. Fifty two healthy women were taken as the controls. The thyroid dysfunction and serum prolactin level were reviewed in cases and in the controls.
  
  
  RESULTS
  Mean serum prolactin level was found to be significantly higher in the cases as compared to the controls. Mean serum fT3 and fT4 level in the hyperprolactinemic cases (mean = 2.67, SD = 1.04 pg/ml) and (mean = 1.38, SD = 0.51 ng/dl respectively) were slightly lower as compared to normoprolactinemic cases (mean = 3.21, SD = 1.86 pg/ml) and (mean = 1.73, SD = 1.37 ng/dl) respectively. Mean TSH of normoprolactinemic and hyperprolactinemic cases were comparable (P= 0.049). There was positive correlation between prolactin, BMI and TSH whereas negative correlation of prolactin was seen with fT3, fT4 and age. In hyperprolactainemic cases, prolactin was found to be negatively correlated with TSH (r= -0.155,P= 0.491) whereas prolactin was positively correlated with TSH (r= 0.296,P= 0.126) in normoprolactainemic cases.
  
  
  CONCLUSIONS
  Thus, hyperprolactinemia with thyroid dysfunction may be contributory hormonal factor in patient with amenorrhoea and as such, estimation of prolactin, fT3, fT4 and TSH should be included for diagnostic evaluation of amenorrhea.
authors.affiliation: Department of Biochemistry, Universal College of Medical Sciences, Ranigaon, Bhairahawa, Nepal.
authors.forename: Sujata
authors.initials: S
authors.lastname: Shrestha
authors.affiliation: Department of Biochemistry, Universal College of Medical Sciences, Ranigaon, Bhairahawa, Nepal.
authors.forename: Sunita
authors.initials: S
authors.lastname: Neupane
authors.affiliation: Department of Biochemistry, Universal College of Medical Sciences, Ranigaon, Bhairahawa, Nepal.
authors.forename: Narayan
authors.initials: N
authors.lastname: Gautam
authors.affiliation: Department of Biochemistry, Universal College of Medical Sciences, Ranigaon, Bhairahawa, Nepal.
authors.forename: Raju Kumar
authors.initials: RK
authors.lastname: Dubey
authors.affiliation: Department of Biochemistry, Universal College of Medical Sciences, Ranigaon, Bhairahawa, Nepal.
authors.forename: Amit Chandra
authors.initials: AC
authors.lastname: Jha
authors.affiliation: Department of Gynecology, Universal College of Medical Sciences, Ranigaon, Bhairahawa, Nepal.
authors.forename: Nilesh Raj
authors.initials: NR
authors.lastname: Doshi
authors.affiliation: Department of Biochemistry, Universal College of Medical Sciences, Ranigaon, Bhairahawa, Nepal.
authors.forename: Archana
authors.initials: A
authors.lastname: Jayan
keywords: Amenorrhea; Thyroid Stimulating Hormone (TSH); prolactin