title: Polycystic ovary syndrome and mental disorders: a systematic review and exploratory meta-analysis.
abstract: BACKGROUND
  The association between depression, anxiety, and polycystic ovary syndrome (PCOS) is still unclear. Therefore, a systematic review and meta-analysis was conducted to assess the rates of comorbid psychiatric disorders among women with PCOS compared to women without it.
  
  
  METHODS
  PubMed/MEDLINE, Embase, PsycINFO, and Web of Science databases were searched from inception to November 27, 2015. Studies were eligible for inclusion if they were original reports in which the rates of mood (bipolar disorder, dysthymia, or major depressive disorder), obsessive-compulsive spectrum disorders, trauma- and stressor-related disorders, anxiety disorders or psychotic disorders, somatic symptom and related disorders, or eating disorders had been investigated among women with an established diagnosis of PCOS and compared with women without PCOS. Psychiatric diagnosis should have been established by means of a structured diagnostic interview or through a validated screening tool. Data were extracted and pooled using random effects models.
  
  
  RESULTS
  Six studies were included in the meta-analysis; of these, five reported the rates of anxiety and six provided data on the rates of depression. The rate of subjects with anxiety symptoms was higher in patients with PCOS compared to women without PCOS (odds ratio (OR) =2.76; 95% confidence interval (CI) 1.26 to 6.02; Log OR =1.013;P=0.011). The rate of subjects with depressive symptoms was higher in patients with PCOS compared to women without PCOS (OR =3.51; 95% CI 1.97 to 6.24; Log OR =1.255;P<0.001).
  
  
  CONCLUSIONS
  Anxiety and depression symptoms are more prevalent in patients with PCOS.
authors.affiliation: Department of Psychiatry, Federal University of São Paulo (Escola Paulista de Medicina - UNIFESP), São Paulo, SP, Brazil.
authors.forename: Sergio Luís
authors.initials: SL
authors.lastname: Blay
authors.affiliation: Department of Psychiatry, Fortaleza University, Fortaleza, Ceará, Brazil.
authors.forename: João Vicente Augusto
authors.initials: JV
authors.lastname: Aguiar
authors.affiliation: Laboratory of Molecular Psychiatry and Department of Psychiatry, Federal University of Rio Grande do Sul, Rio Grande do Sul, Brazil.
authors.forename: Ives Cavalcante
authors.initials: IC
authors.lastname: Passos
keywords: anxiety; depression; epidemiological survey; meta-analysis; polycystic ovary syndrome; systematic review