title: The mitokine quest(ion).
abstract: Cells and organisms adapt to mitochondrial dysfunction by activating the mitochondrial unfolded protein response (UPR), which is regulated by mitochondrial-to-nuclear communication; and UPR activation can also be transmitted between different cell types suggesting a role in tissue coordination. Shao and colleagues now identify a neuronal circuit and a secreted neuropeptide required for cell non-autonomous UPR regulation.
authors.affiliation: University of Massachusetts Medical School, Department of Molecular, Cell and Cancer Biology, Lazare Medical Research Building, Worcester, MA 01605, USA.|Weill Cornell Medical College, BCMB Allied Program, New York, NY 10065, USA.
authors.forename: Pan
authors.initials: P
authors.lastname: Deng
authors.affiliation: University of Massachusetts Medical School, Department of Molecular, Cell and Cancer Biology, Lazare Medical Research Building, Worcester, MA 01605, USA.|Weill Cornell Medical College, BCMB Allied Program, New York, NY 10065, USA.
authors.forename: Cole M
authors.initials: CM
authors.lastname: Haynes
mesh_terms: D008928:Mitochondria; D009474:Neurons; D009479:Neuropeptides; D056811:Unfolded Protein Response
chemical_list: D009479:Neuropeptides