title: United we stand: big roles for small RNA gene clusters.
abstract: Prokaryotes and eukaryotes evolved relatively similar RNA-based molecular mechanisms to fight potentially deleterious nucleic acids coming from phages, transposons, or viruses. Short RNAs guide effector complexes toward their targets to be silenced or eliminated. These short immunity RNAs are transcribed from clustered loci. Unexpectedly and strikingly, bacterial and eukaryotic immunity RNA clusters share substantial functional and mechanistic resemblances in fighting nucleic acid intruders.
authors.affiliation: Inserm U835 Biochimie Pharmaceutique, Rennes University, F-35043 Rennes, France.|Biosit, Rennes University/Université Européenne de Bretagne, F-35043 Rennes, France.
authors.forename: Brice
authors.initials: B
authors.lastname: Felden
authors.affiliation: Biosit, Rennes University/Université Européenne de Bretagne, F-35043 Rennes, France.|Centre National de la Recherche Scientifique UMR 6290, Institut de Génétique et Développement de Rennes, F-35043 Rennes, France.
authors.forename: Luc
authors.initials: L
authors.lastname: Paillard
mesh_terms: D060565:Argonaute Proteins / Q000235:genetics / Q000276:immunology*; D001435:Bacteriophages / Q000235:genetics / Q000472:pathogenicity; D064113:CRISPR-Cas Systems / Q000276:immunology*; D064112:Clustered Regularly Interspaced Short Palindromic Repeats / Q000276:immunology; D004251:DNA Transposable Elements / Q000276:immunology; D056890:Eukaryota / Q000235:genetics / Q000276:immunology* / Q000821:virology; D010957:Plasmids / Q000737:chemistry / Q000276:immunology; D011387:Prokaryotic Cells / Q000276:immunology* / Q000821:virology; D000094704:RNA, Guide, CRISPR-Cas Systems / Q000235:genetics / Q000276:immunology; D034741:RNA, Small Interfering / Q000235:genetics / Q000276:immunology*
chemical_list: D060565:Argonaute Proteins; D004251:DNA Transposable Elements; D000094704:RNA, Guide, CRISPR-Cas Systems; D034741:RNA, Small Interfering
keywords: CRISPR; RNA evolution; RNA gene cluster; regulatory RNA