title: Current Role of Platelet Function Testing in Percutaneous Coronary Intervention and Coronary Artery Bypass Grafting.
abstract: There is interindividual variability in the pharmacodynamic response to antiplatelet medications. High on-treatment platelet reactivity, reflecting a failure to achieve adequate platelet inhibition, is associated with a higher risk for thrombotic events. Low on-treatment platelet reactivity, or an enhanced response to antiplatelet medications, has been linked to a higher risk for bleeding. There is evidence for the prognostic value of platelet function testing for risk prediction. This review presents the current evidence regarding platelet function testing in patients undergoing percutaneous cardiac intervention and coronary artery bypass grafting. The possible role of platelet function testing for individualized antiplatelet treatment is highlighted.
authors.affiliation: Department of Cardiology, Ludwig-Maximilians-Universität München (LMU Munich), Marchioninistr. 15, Munich 81377, Germany.
authors.forename: Lisa
authors.initials: L
authors.lastname: Gross
authors.affiliation: Department of Cardiology, Ludwig-Maximilians-Universität München (LMU Munich), Marchioninistr. 15, Munich 81377, Germany; DZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany. Electronic address: dirk.sibbing@med.uni-muenchen.de.
authors.forename: Dirk
authors.initials: D
authors.lastname: Sibbing
mesh_terms: D054058:Acute Coronary Syndrome / Q000188:drug therapy / Q000601:surgery*; D001792:Blood Platelets / Q000502:physiology*; D001026:Coronary Artery Bypass; D006801:Humans; D062645:Percutaneous Coronary Intervention; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D010979:Platelet Function Tests; D011183:Postoperative Complications / Q000097:blood / Q000517:prevention & control*; D013927:Thrombosis / Q000097:blood / Q000517:prevention & control*
chemical_list: D010975:Platelet Aggregation Inhibitors
keywords: CABG; Guidance of treatment; PCI; Platelet function testing; Platelet reactivity; Risk prediction; Tailored antiplatelet therapy; Transfusion algorithm