title: [A role of genetic factors and related disorder of the folate cycle in ischemic stroke].
abstract: OBJECTIVE
  To study a role of MTHFR mutations and their associations with the disturbances of basic parameters of the folate cycle in the development of ischemic stroke (IS).
  
  
  METHODS
  Fifty-one post-stroke patients, 26 women and 25 men, aged from 29 to 87 years, were included in the study. The control group consisted of 47 healthy people, 23 women and 24 men, aged from 30 to 83 years. MTHFR: rs1801131 and rs1801133 polymorphisms were genotyped. Contents of folate, B12 and homocysteine were measured.
  
  
  RESULTS
  The risk group which was characterized by the presence of risk variants of rs1801131 and rs1801133 polymorphisms, changes in the parameters of the folate cycle (the decrease in B12 concentration (≤500 pg/ml)) in the combination with hyperhomocysteinemia (≥13 mcmol/L) was identified.
  
  
  CONCLUSIONS
  The disturbance of the folate cycle, including gene variations, is a basic pathogenetic link in the development of cerebral atherosclerosis and associated cerebrovascular diseases.
authors.affiliation: Serbsky Federal Medical Research Centre for Psychiatry and Narcology of the Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: V M
authors.initials: VM
authors.lastname: Shklovsky
authors.affiliation: Institute for Information Transmission Problems Russian Academy of Sciences, Moscow, Russia.
authors.forename: I P
authors.initials: IP
authors.lastname: Lukashevich
authors.affiliation: Center of Speech Pathology and Reabilitation, Moscow Department of Health, Moscow, Russia.
authors.forename: A Yu
authors.initials: AY
authors.lastname: Remennik
authors.affiliation: Institute for Information Transmission Problems Russian Academy of Sciences, Moscow, Russia.
authors.forename: S M
authors.initials: SM
authors.lastname: Gerasimova
authors.affiliation: Center of Speech Pathology and Reabilitation, Moscow Department of Health, Moscow, Russia.
authors.forename: G S
authors.initials: GS
authors.lastname: Selishchev
authors.affiliation: Serbsky Federal Medical Research Centre for Psychiatry and Narcology of the Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: D I
authors.initials: DI
authors.lastname: Malin
authors.affiliation: Center of Speech Pathology and Reabilitation, Moscow Department of Health, Moscow, Russia.
authors.forename: V V
authors.initials: VV
authors.lastname: Valyeva
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002545:Brain Ischemia / Q000378:metabolism*; D016022:Case-Control Studies; D005260:Female; D005492:Folic Acid / Q000378:metabolism*; D005838:Genotype; D006801:Humans; D020138:Hyperhomocysteinemia; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012307:Risk Factors; D020521:Stroke / Q000378:metabolism*
chemical_list: D005492:Folic Acid; D042965:Methylenetetrahydrofolate Reductase (NADPH2)