title: Molecular Classification of Diffuse Large B-cell Lymphoma: What Is Clinically Relevant?
abstract: Major progress in the understanding of diffuse large B-cell lymphoma (DLBCL) biology has been made in the last decade. Many specific compounds have now entered early phase clinical trials. However, further efforts are needed to find an accurate, fast, reproducible, and affordable technique to translate DLBCL subtype determination by gene expression profiles into clinical application. This article discusses the advantages and drawbacks of the currently available techniques of DLBCL subtype determination as well as important prognostic implications related to the cell of origin. Furthermore, the article provides a schematic description of how molecularly defined DLBCL subtypes could guide tailored therapy.
authors.affiliation: Laboratory of Hematology, Hospices Civils de Lyon, Hôpital Lyon Sud, 165 Chemin du Grand Revoyet, Pierre-Bénite 69310, France; Université Claude Bernard Lyon1, Université de Lyon, Lyon, France; Centre de Recherche en Cancérologie de Lyon, INSERM 1052 CNRS 5286, Lyon, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Sujobert
authors.affiliation: Université Claude Bernard Lyon1, Université de Lyon, Lyon, France; Centre de Recherche en Cancérologie de Lyon, INSERM 1052 CNRS 5286, Lyon, France; Department of Hematology, Hospices Civils de Lyon, Hôpital Lyon Sud, 165 Chemin du Grand Revoyet, Pierre-Bénite 69310, France. Electronic address: gilles.salles@chu-lyon.fr.
authors.forename: Gilles
authors.initials: G
authors.lastname: Salles
authors.affiliation: Université Claude Bernard Lyon1, Université de Lyon, Lyon, France; Centre de Recherche en Cancérologie de Lyon, INSERM 1052 CNRS 5286, Lyon, France; Department of Hematology, Hospices Civils de Lyon, Hôpital Lyon Sud, 165 Chemin du Grand Revoyet, Pierre-Bénite 69310, France.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Bachy
mesh_terms: D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000145:classification / Q000235:genetics / Q000378:metabolism / Q000628:therapy
keywords: Activated B-cell like subtype; Aggressive lymphoma; Cell-of-origin; Diffuse large B-cell lymphoma; Germinal center subtype; Personalized medicine; Targeted therapy