title: Immune Hemolytic Anemia (Paroxysmal Cold Hemoglobinuria) Preceding Burkitt Lymphoma in a 12-Year-Old Child.
abstract: Autoimmune hemolytic anemia (AIHA) in childhood, including paroxysmal cold hemoglobinuria, is an uncommon, potentially life-threatening disorder. AIHA is a recognized complication of several varieties of lymphoproliferative disorders, including high-grade B-cell lymphoma, but it has not been associated with Burkitt lymphoma in people without an underlying immunodeficiency. When AIHA occurs in association with lymphoproliferative disorders, it may precede or accompany the diagnosis of malignant disease or herald relapse. We report a novel case of a previously healthy child diagnosed with paroxysmal cold hemoglobinuria 14 months preceding the development of Burkitt lymphoma.
authors.affiliation: Department of Pediatrics, Beaumont Children's Hospital, Oakland University William Beaumont School of Medicine, Royal Oak, MI.
authors.forename: Majd T
authors.initials: MT
authors.lastname: Ghanim
authors.forename: Brian
authors.initials: B
authors.lastname: Berman
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001803:Blood Transfusion; D002051:Burkitt Lymphoma / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D002648:Child; D006457:Hemoglobinuria, Paroxysmal / Q000209:etiology* / Q000628:therapy; D006801:Humans; D008297:Male; D012074:Remission Induction