title: High-frequency rTMS for the Treatment of Chronic Fatigue Syndrome: A Case Series.
abstract: Structural and functional abnormalities of the prefrontal cortex seem to correlate with fatigue in patients with chronic fatigue syndrome (CFS). We consecutively applied facilitatory high-frequency repetitive transcranial magnetic stimulation (rTMS) to the dorsolateral prefrontal cortex (DLPFC) of seven CFS patients over three days. Five patients completed the 3-day protocol without any adverse events. For the other two patients, we had to reduce the stimulation intensity in response to mild adverse reactions. In most of the patients, treatment resulted in an improvement of fatigue symptoms. High-frequency rTMS applied over the DLPFC can therefore be a potentially useful therapy for CFS patients.
authors.affiliation: Department of Rehabilitation Medicine, The Jikei University School of Medicine, Japan.
authors.forename: Wataru
authors.initials: W
authors.lastname: Kakuda
authors.forename: Ryo
authors.initials: R
authors.lastname: Momosaki
authors.forename: Naoki
authors.initials: N
authors.lastname: Yamada
authors.forename: Masahiro
authors.initials: M
authors.lastname: Abo
mesh_terms: D000293:Adolescent; D000328:Adult; D015673:Fatigue Syndrome, Chronic / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017397:Prefrontal Cortex / Q000503:physiopathology; D050781:Transcranial Magnetic Stimulation / Q000379:methods*; D055815:Young Adult