title: Human papillomavirus-induced oropharyngeal cancer in Hispanics in the United States.
abstract: Determine disparities in survival outcome and clinical presentation between Hispanic and non-Hispanic white patients with human papillomavirus-positive oropharyngeal squamous cell carcinoma.
  
  
  
  Retrospective clinical research.
  
  
  
  Clinical data on Hispanics and non-Hispanic white patients with diagnosis of human papillomavirus/p16-positive oropharyngeal squamous cell carcinoma were drawn from a tumor registry from the University of Miami Hospitals and Clinics from 2008 to 2014. Of 436 patients with oropharyngeal squamous cell carcinoma, 237 patents met inclusion criteria. Patient's age, gender, smoking history, alcohol history, race/ethnicity, tumor T stage, nodal N stage, and composite TNM stage were included in the analysis. Associations between race and other categorical variables were explored with χ2test or Fisher exact test where appropriate. Survival curves were generated using the Kaplan-Meier method.
  
  
  
  Significant differences in clinical presentation was detected between Hispanic (N = 70) and non-Hispanic white (N = 167) patients. Hispanic human papillomavirus-positive oropharyngeal squamous cell carcinoma patients showed a higher proportion of women with disease, a higher proportion of patients presenting with tonsil rather than tongue base primary subsite cancer, and a higher proportion of patients who do not consume alcohol compared to non-Hispanic white human papillomavirus-positive oropharyngeal squamous cell carcinoma patients. A statistically significant survival difference between these two ethnic groups was not detected in the current dataset.
  
  
  
  Unique differences in clinical presentations between Hispanic patients and non-Hispanic whites with human papillomavirus-positive oropharyngeal squamous cell carcinoma were detected. This may be the first study to report novel clinical presentation in Hispanic human papillomavirus-positive patients with oropharyngeal squamous cell carcinoma living in the United States.
  
  
  
  4. Laryngoscope, 127:1097-1101, 2017.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, University of Miami Miller School of Medicine, Miami, Florida, U.S.A.
authors.forename: Giovana R
authors.initials: GR
authors.lastname: Thomas
authors.affiliation: Department of Public Health Sciences, Biostatistics Collaboration and Consulting Core, University of Miami Miller School of Medicine, Miami, Florida, U.S.A.
authors.forename: Kaming
authors.initials: K
authors.lastname: Lo
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, University of Miami Miller School of Medicine, Miami, Florida, U.S.A.
authors.forename: Raphael
authors.initials: R
authors.lastname: Nwojo
mesh_terms: D005260:Female; D005431:Florida; D006630:Hispanic or Latino / Q000706:statistics & numerical data*; D052162:Human papillomavirus 16 / Q000472:pathogenicity*; D006801:Humans; D008297:Male; D009959:Oropharyngeal Neoplasms / Q000208:ethnology* / Q000821:virology*; D030361:Papillomavirus Infections / Q000208:ethnology* / Q000821:virology*; D012042:Registries; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate
keywords: Hispanic; Human papillomavirus-positive; oropharynx cancer; squamous cell carcinoma; survival