title: Paclitaxel-loaded poly(lactide-co-glycolide)/poly(ethylene vinyl acetate) composite for stent coating by ultrasonic atomizing spray.
abstract: The mixture of poly(lactide-co-glycolide) (PLGA) and poly(ethylene vinyl acetate) (PEVA) forms a homogeneous liquid in an organic solvent such as tetrahydrofuran, and a phase-separated PLGA/PEVA composite can be prepared from it by evaporating the organic solvent. Exploiting this phenomenon, we designed a novel method of preparing a drug-loaded PLGA/PEVA composite and used it for coating drug-eluting stents (DESs). Paclitaxel (PTX), an anticancer drug, was chosen as a model drug. PLGA acts as a microdepot for PTX, and PEVA provides mechanical strength to the coating material. The presence of PLGA in the PLGA/PEVA composite suppressed PTX crystallization in the coating material, and PTX showed a sustained release rate over more than 30 days. The mechanical strength of the PLGA/PEVA composite was better than that of PEVA used as a control. After coating the stent with a PLGA/PEVA composite using ultrasonic atomizing spray, the morphology of the coated material was observed by scanning electron microscopy, and the release pattern of PTX was measured by high-performance liquid chromatography.
authors.affiliation: College of Pharmacy, Korea University, Jochiwon, Yeongi, Chungnam, 339-700, Korea.
authors.forename: Soon Hong
authors.initials: SH
authors.lastname: Yuk
authors.affiliation: Biomedical Research Center, Korea Institute of Science and Technology, Seoul, 136-791, Korea.
authors.forename: Keun Sang
authors.initials: KS
authors.lastname: Oh
authors.affiliation: College of Pharmacy, Korea University, Jochiwon, Yeongi, Chungnam, 339-700, Korea.
authors.forename: Jinah
authors.initials: J
authors.lastname: Park
authors.affiliation: Department of Maxillofacial Biomedical Engineering, School of Dentistry, Kyung Hee University, 136-791, Korea.
authors.forename: Soon-Joong
authors.initials: SJ
authors.lastname: Kim
authors.affiliation: Department of Maxillofacial Biomedical Engineering, School of Dentistry, Kyung Hee University, 136-791, Korea.
authors.forename: Jung Ho
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Department of Maxillofacial Biomedical Engineering, School of Dentistry, Kyung Hee University, 136-791, Korea.
authors.forename: Il Keun
authors.initials: IK
authors.lastname: Kwon
keywords: Drug-eluting stents; PLGA/PEVA composite; Paclitaxel; Sustained release; Ultrasonic atomizing spray