title: The Roles of the Unique Prolyl Isomerase Pin1 in Cancer-Related Viral and Bacterial Infections.
abstract: Infection is the process of pathogen invasion, as well as the host reaction to the foreign agents. Proline-directed phosphorylation is a major regulatory mechanism that regulates the function of fundamental proteins involved in infection and infection-induced cancer. Recently, the identification of the phosphorylation-dependent prolyl isomerase Pin1 has uncovered a unique regulatory signaling mechanism controlling protein conformation and function after phosphorylation. Pin1 is the only proline isomerase that specifically recognizes certain Pro-directed Ser/Thr phosphorylation motifs. Pin1 has emerged as a major regulator of cancerrelated viral and bacterial infections notably via activating Toll-like receptor signaling and NF-κB pathways. This paper will specifically review recent findings on the role of Pin1 in cancer-related viral and bacterial infections and also discuss newly discovered Pin1 inhibitors as promising drugs for the prevention and treatment of viral and bacterial infections and associated tumorigenesis.
authors.forename: J
authors.initials: J
authors.lastname: Wang
authors.forename: X-H
authors.initials: XH
authors.lastname: Liao
authors.forename: M
authors.initials: M
authors.lastname: Zheng
authors.forename: D
authors.initials: D
authors.lastname: Yang
authors.forename: X Z
authors.initials: XZ
authors.lastname: Zhou
authors.forename: H
authors.initials: H
authors.lastname: Liu
authors.affiliation: Fujian Key Laboratory for Translational Research in Cancer and Neurodegenerative Diseases, Institute for Translational Medicine, Fujian Medical University, Fuzhou, Fujian 350108, China.
authors.forename: K P
authors.initials: KP
authors.lastname: Lu
mesh_terms: D000818:Animals; D001424:Bacterial Infections / Q000378:metabolism*; D063646:Carcinogenesis / Q000378:metabolism; D006801:Humans; D009369:Neoplasms / Q000378:metabolism*; D019696:Peptidylprolyl Isomerase / Q000378:metabolism*; D010766:Phosphorylation / Q000502:physiology; D011487:Protein Conformation; D014777:Virus Diseases / Q000378:metabolism*
chemical_list: D019696:Peptidylprolyl Isomerase
keywords: ATRA; NF-kB; Prolyl isomerase Pin1; Toll-like receptors; cancer-related viral and bacterial infections; inflammatory response