title: Novel antibacterial polymeric nanocomposite for smart co-delivery of anticancer drugs.
abstract: Here a novel antibacterial nanocomposite was developed for combination cancer therapy. The synthesized nanocarrier was characterized by FTIR,1H NMR, thermogravimetric analysis (TGA), and FESEM-EDX. Its antibacterial activity was assessed by determining minimum inhibitory concentration (MIC) values. Doxorubicin (DOX) and methotrexate (MTX) conjugation with nanocarrier sustained the release of both drugs with apparent pH-triggered manner. Co-administration of DOX with MTX leads to an efficient anticancer performance to MCF7 cell lines verified by qRT-PCR and MTT assay tests. It was concluded that this novel drug delivery vehicle makes antibacterial and anticancer therapeutic processes proceed spontaneously, representing more efficient drug delivery system in nanomedicine. [Formula: see text].
authors.affiliation: a Chemistry Department , Azarbaijan Shahid Madani University , Tabriz , Iran.|b Drug Applied Research Center, Tabriz University of Medical Sciences , Tabriz , Iran.
authors.forename: Elham
authors.initials: E
authors.lastname: Zakerzadeh
authors.affiliation: c Biotechnology Research Center, Tabriz University of Medical Sciences , Tabriz , Iran.|d Department of Medical Nanotechnology , School of Advanced Medical Science, Tabriz University of Medical Sciences , Tabriz , Iran.
authors.forename: Effat
authors.initials: E
authors.lastname: Alizadeh
authors.affiliation: b Drug Applied Research Center, Tabriz University of Medical Sciences , Tabriz , Iran.
authors.forename: Hossein
authors.initials: H
authors.lastname: Samadi Kafil
authors.affiliation: b Drug Applied Research Center, Tabriz University of Medical Sciences , Tabriz , Iran.
authors.forename: Azad
authors.initials: A
authors.lastname: Mohammad Hassanzadeh
authors.affiliation: b Drug Applied Research Center, Tabriz University of Medical Sciences , Tabriz , Iran.|d Department of Medical Nanotechnology , School of Advanced Medical Science, Tabriz University of Medical Sciences , Tabriz , Iran.
authors.forename: Roya
authors.initials: R
authors.lastname: Salehi
authors.affiliation: a Chemistry Department , Azarbaijan Shahid Madani University , Tabriz , Iran.
authors.forename: Mehrdad
authors.initials: M
authors.lastname: Mahkam
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D004317:Doxorubicin / Q000737:chemistry / Q000494:pharmacology; D004337:Drug Carriers / Q000737:chemistry* / Q000494:pharmacology; D065546:Drug Liberation; D006801:Humans; D061986:MCF-7 Cells; D053761:Nanocomposites / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry; D011108:Polymers / Q000737:chemistry* / Q000494:pharmacology*; D012822:Silicon Dioxide / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D004337:Drug Carriers; D011108:Polymers; D012822:Silicon Dioxide; D004317:Doxorubicin
keywords: Antibacterial polymers; combination therapy; dual anticancer drug; nanocomposite; stimuli responsive; sustained release