title: Short- and Long-Term Mortality Rates of Elderly Acute Kidney Injury Patients Who Underwent Continuous Renal Replacement Therapy.
abstract: BACKGROUND
  The world's population is aging faster and the incidence of acute kidney injury (AKI) needing continuous renal replacement therapy (CRRT) is increasing in elderly population. The outcome of AKI needing CRRT in elderly patients is known to be poor. However, the definitions of elderly used in the previous literatures were diverse and, there were few data that compared the long-term mortality rates of these patients with middle aged patients. This study was aimed to evaluate this issue.
  
  
  METHODS
  This study was a single-center, retrospective cohort study of patients who underwent CRRT from January 2013 to December 2015. The patients were divided into the following four age cohorts: middle-aged (55-64), young-old (65-74), middle-old (75-84), and old-old (≥85). The short- and long-term mortality rates for each age cohort were compared.
  
  
  RESULTS
  A total of 562 patients met the inclusion criteria. The short-term mortality rate was 57.3% in the entire cohort. Compared with the middle-aged cohort, the middle-old cohort (HR 1.48 (1.09-2.02), p = 0.012) and the old-old cohort (HR 2.33 (1.30-4.19), p = 0.005) showed an increased short-term mortality rate along with an increased SOFA score, acidemia and a prolonged prothrombin time. When we analyzed the long-term mortality rate of the 238 survived patients, the middle-old cohort (HR 3.76 (1.84-7.68), p<0.001), the old-old cohort (HR 4.40(1.20-16.10), p = 0.025), a lower BMI, the presence of liver cirrhosis, the presence of congestive heart failure and a history of sepsis were independent risk factors for the prediction of long-term mortality.
  
  
  CONCLUSIONS
  Compared with the middle-aged cohort, the middle-old and the old-old cohort showed an increased short-term and long-term mortality rate. However, in the young-old cohort, neither the short-term nor the long-term mortality rate was increased.
authors.affiliation: Department of Internal Medicine, Pusan National University School of Medicine, Busan, Republic of Korea.|Biomedical Research Institute, Pusan National University Hospital, Busan, Republic of Korea.
authors.forename: Harin
authors.initials: H
authors.lastname: Rhee
authors.affiliation: Department of Nursing, Pusan National University Hospital, Busan, Republic of Korea.
authors.forename: Keum Sook
authors.initials: KS
authors.lastname: Jang
authors.affiliation: Department of Internal Medicine, Pusan National University School of Medicine, Busan, Republic of Korea.|Biomedical Research Institute, Pusan National University Hospital, Busan, Republic of Korea.
authors.forename: Jong Man
authors.initials: JM
authors.lastname: Park
authors.affiliation: Department of Internal Medicine, Pusan National University School of Medicine, Busan, Republic of Korea.
authors.forename: Jin Suk
authors.initials: JS
authors.lastname: Kang
authors.affiliation: Department of Internal Medicine, Pusan National University School of Medicine, Busan, Republic of Korea.
authors.forename: Na Kyoung
authors.initials: NK
authors.lastname: Hwang
authors.affiliation: Department of Internal Medicine, Pusan National University School of Medicine, Busan, Republic of Korea.
authors.forename: Il Young
authors.initials: IY
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Pusan National University School of Medicine, Busan, Republic of Korea.|Biomedical Research Institute, Pusan National University Hospital, Busan, Republic of Korea.
authors.forename: Sang Heon
authors.initials: SH
authors.lastname: Song
authors.affiliation: Department of Internal Medicine, Pusan National University School of Medicine, Busan, Republic of Korea.|Biomedical Research Institute, Pusan National University Hospital, Busan, Republic of Korea.
authors.forename: Eun Young
authors.initials: EY
authors.lastname: Seong
authors.affiliation: Department of Internal Medicine, Pusan National University School of Medicine, Busan, Republic of Korea.
authors.forename: Dong Won
authors.initials: DW
authors.lastname: Lee
authors.affiliation: Department of Internal Medicine, Pusan National University School of Medicine, Busan, Republic of Korea.
authors.forename: Soo Bong
authors.initials: SB
authors.lastname: Lee
authors.affiliation: Department of Internal Medicine, Pusan National University School of Medicine, Busan, Republic of Korea.|Biomedical Research Institute, Pusan National University Hospital, Busan, Republic of Korea.
authors.forename: Ihm Soo
authors.initials: IS
authors.lastname: Kwak
mesh_terms: D058186:Acute Kidney Injury / Q000401:mortality*; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D016030:Kidney Transplantation / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate