title: Melanocytic Nevi and the Genetic and Epigenetic Control of Oncogene-Induced Senescence.
abstract: Melanocytic nevi represent benign clonal proliferations of the melanocytes in the skin that usually remain stable in size and behavior or disappear during life. Infrequently, melanocytic nevi undergo malignant transformation to melanoma. Understanding molecular and cellular mechanisms underlying oncogene-induced senescence should help identify pathways underlying melanoma development, leading to the development of new strategies for melanoma prevention and early detection.
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 108 N. Greene St., Baltimore, MD 21201, USA.
authors.forename: Jennifer M
authors.initials: JM
authors.lastname: Huang
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 108 N. Greene St., Baltimore, MD 21201, USA.
authors.forename: Ijeuru
authors.initials: I
authors.lastname: Chikeka
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 108 N. Greene St., Baltimore, MD 21201, USA; Research & Development Service, VA Maryland Health Care System, Baltimore, MD, 21201, USA; Department of Dermatology, University of Maryland School of Medicine, Baltimore, MD 21201, USA. Electronic address: THornyak@som.umaryland.edu.
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Hornyak
mesh_terms: D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D016922:Cellular Senescence / Q000235:genetics*; D044127:Epigenesis, Genetic / Q000235:genetics*; D006801:Humans; D008545:Melanoma / Q000235:genetics*; D009508:Nevus, Pigmented / Q000235:genetics*; D009857:Oncogenes / Q000235:genetics*; D012878:Skin Neoplasms / Q000235:genetics*
keywords: Melanocyte; Melanoma; Nevi; Oncogene; Senescence