title: Association of Systemic Arterial Properties With Right Ventricular Morphology: The Multi-Ethnic Study of Atherosclerosis (MESA)-Right Ventricle Study.
abstract: Systemic arterial stiffness is recognized as a major contributor to development of left ventricular dysfunction and failure; however, the relationship of systemic arterial properties and the right ventricle (RV) is unknown.
  
  
  
  The associations between systemic arterial measures (total arterial compliance [TAC], systemic vascular resistance [SVR], and aortic augmentation index [AI]) and RV morphology (mass, end-systolic [RVESV] and end-diastolic volume [RVEDV], and ejection fraction [RVEF]) were examined using data from the Multi-Ethnic Study of Atherosclerosis. All analyses were adjusted for anthropometric, demographic, and clinical variables and the corresponding left ventricular parameter. A total of 3842 subjects without clinical cardiovascular disease were included with a mean age of 61 years, 48% male, 39% non-Hispanic white, 25% Chinese-American, 23% Hispanic, and 13% black. RV measures were within normal range for age and sex. A 1-mL/mm Hg decrease in TAC was associated with 3.9-mL smaller RVESV, 7.6-mL smaller RVEDV, and 2.4-g lower RV mass. A 5-Wood-unit increase in SVR was associated with 0.6-mL decrease in RVESV, 1.7-mL decrease in RVEDV, and 0.4-g decrease in RV mass. A 1% increase in AI was associated with 0.2-mL decrease in RVEDV. We found significant effect modification by age, sex, and race for some of these relationships, with males, whites, and younger individuals having greater decreases in RV volumes and mass.
  
  
  
  Markers of increased systemic arterial load were associated with smaller RV volumes and lower RV mass in a population of adults without clinical cardiovascular disease.
authors.affiliation: Department of Medicine, Tufts Medical Center, Boston, MA.|Clinical and Translational Science Institute, Tufts Medical Center, Boston, MA.
authors.forename: Nadine
authors.initials: N
authors.lastname: Al-Naamani
authors.affiliation: Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
authors.forename: Julio A
authors.initials: JA
authors.lastname: Chirinos
authors.affiliation: Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
authors.forename: Payman
authors.initials: P
authors.lastname: Zamani
authors.affiliation: Clinical and Translational Science Institute, Tufts Medical Center, Boston, MA.
authors.forename: Robin
authors.initials: R
authors.lastname: Ruthazer
authors.affiliation: Clinical and Translational Science Institute, Tufts Medical Center, Boston, MA.
authors.forename: Jessica K
authors.initials: JK
authors.lastname: Paulus
authors.affiliation: Department of Medicine, Tufts Medical Center, Boston, MA.
authors.forename: Kari E
authors.initials: KE
authors.lastname: Roberts
authors.affiliation: Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY.|Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY.
authors.forename: R Graham
authors.initials: RG
authors.lastname: Barr
authors.affiliation: Department of Medicine, Johns Hopkins University, Baltimore, MD.
authors.forename: Joao A
authors.initials: JA
authors.lastname: Lima
authors.affiliation: Radiology and Imaging Sciences, National Institutes of Health/Clinical Center, Bethesda, MD.
authors.forename: David A
authors.initials: DA
authors.lastname: Bluemke
authors.affiliation: Department of Biostatistics, University of Washington, Seattle, WA.
authors.forename: Richard
authors.initials: R
authors.lastname: Kronmal
authors.affiliation: Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA kawut@exchange.upenn.edu.|Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
authors.forename: Steven M
authors.initials: SM
authors.lastname: Kawut
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D050197:Atherosclerosis / Q000175:diagnosis / Q000208:ethnology / Q000503:physiopathology*; D002318:Cardiovascular Diseases / Q000175:diagnosis* / Q000208:ethnology / Q000503:physiopathology; D005006:Ethnicity; D005260:Female; D005500:Follow-Up Studies; D006352:Heart Ventricles / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006801:Humans; D015994:Incidence; D019028:Magnetic Resonance Imaging, Cine; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013318:Stroke Volume; D014481:United States / Q000453:epidemiology; D059289:Vascular Stiffness / Q000502:physiology*; D016278:Ventricular Function, Right / Q000502:physiology*
keywords: arterial stiffness; artery; magnetic resonance imaging; right ventricle; ventricle