title: Online platform for applying space-time scan statistics for prospectively detecting emerging hot spots of dengue fever.
abstract: Cases of dengue fever have increased in areas of Southeast Asia in recent years. Taiwan hit a record-high 42,856 cases in 2015, with the majority in southern Tainan and Kaohsiung Cities. Leveraging spatial statistics and geo-visualization techniques, we aim to design an online analytical tool for local public health workers to prospectively identify ongoing hot spots of dengue fever weekly at the village level.
  
  
  
  A total of 57,516 confirmed cases of dengue fever in 2014 and 2015 were obtained from the Taiwan Centers for Disease Control (TCDC). Incorporating demographic information as covariates with cumulative cases (365 days) in a discrete Poisson model, we iteratively applied space-time scan statistics by SaTScan software to detect the currently active cluster of dengue fever (reported as relative risk) in each village of Tainan and Kaohsiung every week. A village with a relative risk >1 and p value <0.05 was identified as a dengue-epidemic area. Assuming an ongoing transmission might continuously spread for two consecutive weeks, we estimated the sensitivity and specificity for detecting outbreaks by comparing the scan-based classification (dengue-epidemic vs. dengue-free village) with the true cumulative case numbers from the TCDC's surveillance statistics.
  
  
  
  Among the 1648 villages in Tainan and Kaohsiung, the overall sensitivity for detecting outbreaks increases as case numbers grow in a total of 92 weekly simulations. The specificity for detecting outbreaks behaves inversely, compared to the sensitivity. On average, the mean sensitivity and specificity of 2-week hot spot detection were 0.615 and 0.891 respectively (p value <0.001) for the covariate adjustment model, as the maximum spatial and temporal windows were specified as 50% of the total population at risk and 28 days. Dengue-epidemic villages were visualized and explored in an interactive map.
  
  
  
  We designed an online analytical tool for front-line public health workers to prospectively detect ongoing dengue fever transmission on a weekly basis at the village level by using the routine surveillance data.
authors.affiliation: Center for Geographic Information Science, Research Center for Humanities and Social Sciences, Academia Sinica, 128 Academia Road, Section 2, Nankang, Taipei, 115, Taiwan, ROC.
authors.forename: Chien-Chou
authors.initials: CC
authors.lastname: Chen
authors.affiliation: Center for Geographic Information Science, Research Center for Humanities and Social Sciences, Academia Sinica, 128 Academia Road, Section 2, Nankang, Taipei, 115, Taiwan, ROC.
authors.forename: Yung-Chu
authors.initials: YC
authors.lastname: Teng
authors.affiliation: Center for Geographic Information Science, Research Center for Humanities and Social Sciences, Academia Sinica, 128 Academia Road, Section 2, Nankang, Taipei, 115, Taiwan, ROC.
authors.forename: Bo-Cheng
authors.initials: BC
authors.lastname: Lin
authors.affiliation: Center for Geographic Information Science, Research Center for Humanities and Social Sciences, Academia Sinica, 128 Academia Road, Section 2, Nankang, Taipei, 115, Taiwan, ROC.|Institute of History and Philology, Academia Sinica, 128 Academia Road, Section 2, Nankang, Taipei, 115, Taiwan, ROC.
authors.forename: I-Chun
authors.initials: IC
authors.lastname: Fan
authors.affiliation: Center for Geographic Information Science, Research Center for Humanities and Social Sciences, Academia Sinica, 128 Academia Road, Section 2, Nankang, Taipei, 115, Taiwan, ROC. dachianpig@gmail.com.
authors.forename: Ta-Chien
authors.identifier: 0000-0002-1685-783X
authors.initials: TC
authors.lastname: Chan
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D003715:Dengue / Q000453:epidemiology*; D004196:Disease Outbreaks / Q000706:statistics & numerical data*; D005260:Female; D040362:Geographic Information Systems; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D020407:Internet; D008297:Male; D008875:Middle Aged; D016012:Poisson Distribution; D011446:Prospective Studies; D062486:Public Health Surveillance / Q000379:methods*; D015203:Reproducibility of Results; D012959:Socioeconomic Factors; D062211:Spatio-Temporal Analysis; D013624:Taiwan / Q000453:epidemiology; D055815:Young Adult
keywords: Dengue fever; Flexibility; Real-time; Scan statistics; Spatio-temporal