title: 1-Deoxynojirimycin: Occurrence, Extraction, Chemistry, Oral Pharmacokinetics, Biological Activities and In Silico Target Fishing.
abstract: 1-Deoxynojirimycin (DNJ, C₆H13NO₄, 163.17 g/mol), an alkaloid azasugar or iminosugar, is a biologically active natural compound that exists in mulberry leaves andCommelina communis(dayflower) as well as from several bacterial strains such asBacillusandStreptomycesspecies. Deoxynojirimycin possesses antihyperglycemic, anti-obesity, and antiviral features. Therefore, the aim of this detailed review article is to summarize the existing knowledge on occurrence, extraction, purification, determination, chemistry, and bioactivities of DNJ, so that researchers may use it to explore future perspectives of research on DNJ. Moreover, possible molecular targets of DNJ will also be investigated using suitable in silico approach.
authors.affiliation: Beijing University of Chinese Medicine, Bei San Huan East Road, Beijing 100029, China. linfengtingchan@foxmail.com.
authors.forename: Kuo
authors.initials: K
authors.lastname: Gao
authors.affiliation: Beijing University of Chinese Medicine, Bei San Huan East Road, Beijing 100029, China. zheng1633@163.com.|Beijing Gulou Hospital of Traditional Chinese Medicine, 13 DouFuChi Hutong, Dongcheng District, Beijing 100009, China. zheng1633@163.com.
authors.forename: Chenglong
authors.initials: C
authors.lastname: Zheng
authors.affiliation: Beijing Gulou Hospital of Traditional Chinese Medicine, 13 DouFuChi Hutong, Dongcheng District, Beijing 100009, China. selenss@163.com.
authors.forename: Tong
authors.initials: T
authors.lastname: Wang
authors.affiliation: Beijing University of Chinese Medicine, Bei San Huan East Road, Beijing 100029, China. hh686@126.com.
authors.forename: Huihui
authors.initials: H
authors.lastname: Zhao
authors.affiliation: Beijing University of Chinese Medicine, Bei San Huan East Road, Beijing 100029, China. doctorjuanwang@163.com.
authors.forename: Juan
authors.initials: J
authors.lastname: Wang
authors.affiliation: Beijing University of Chinese Medicine, Bei San Huan East Road, Beijing 100029, China. bucmwzy@126.com.
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Beijing University of Chinese Medicine, Bei San Huan East Road, Beijing 100029, China. zhaixing_918@163.com.
authors.forename: Xing
authors.initials: X
authors.lastname: Zhai
authors.affiliation: Beijing University of Chinese Medicine, Bei San Huan East Road, Beijing 100029, China. 15652605582@163.com.
authors.forename: Zijun
authors.initials: Z
authors.lastname: Jia
authors.affiliation: Beijing University of Chinese Medicine, Bei San Huan East Road, Beijing 100029, China. cjx@bucm.edu.cn.
authors.forename: Jianxin
authors.initials: J
authors.lastname: Chen
authors.affiliation: Beijing Gulou Hospital of Traditional Chinese Medicine, 13 DouFuChi Hutong, Dongcheng District, Beijing 100009, China. 15001394600@163.com.
authors.forename: Yingwu
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Beijing University of Chinese Medicine, Bei San Huan East Road, Beijing 100029, China. wangwei@bucm.edu.cn.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
mesh_terms: D017485:1-Deoxynojirimycin / Q000008:administration & dosage* / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019440:Anti-Obesity Agents / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology; D000998:Antiviral Agents / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology; D001407:Bacillus / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure; D031625:Morus / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry; D013302:Streptomyces / Q000737:chemistry*
chemical_list: D019440:Anti-Obesity Agents; D000998:Antiviral Agents; D007004:Hypoglycemic Agents; D017485:1-Deoxynojirimycin
keywords: Bacillus; anti-obesity; antihyperglycemic; antiviral; fermentation; iminosugar; molecular targets; mulberry; silkworms