title: Preparation of polypyrrole-embedded electrospun poly(lactic acid) nanofibrous scaffolds for nerve tissue engineering.
abstract: Polypyrrole (PPy) is a biocompatible polymer with good conductivity. Studies combining PPy with electrospinning have been reported; however, the associated decrease in PPy conductivity has not yet been resolved. We embedded PPy into poly(lactic acid) (PLA) nanofibersviaelectrospinning and fabricated a PLA/PPy nanofibrous scaffold containing 15% PPy with sustained conductivity and aligned topography. There was good biocompatibility between the scaffold and human umbilical cord mesenchymal stem cells as well as Schwann cells. Additionally, the direction of cell elongation on the scaffold was parallel to the direction of fibers. Our findings suggest that the aligned PLA/PPy nanofibrous scaffold is a promising biomaterial for peripheral nerve regeneration.
authors.affiliation: Key Laboratory of Advanced Materials of Ministry of Education of China, School of Materials Science and Engineering, Tsinghua University, Beijing, China.
authors.forename: Jun-Feng
authors.initials: JF
authors.lastname: Zhou
authors.affiliation: Institute of Orthopedics, Chinese PLA General Hospital, Beijing, China; School of Medicine, Nankai University, Tianjin, China.
authors.forename: Yi-Guo
authors.initials: YG
authors.lastname: Wang
authors.affiliation: Key Laboratory of Advanced Materials of Ministry of Education of China, School of Materials Science and Engineering, Tsinghua University, Beijing, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Cheng
authors.affiliation: Key Laboratory of Advanced Materials of Ministry of Education of China, School of Materials Science and Engineering, Tsinghua University, Beijing, China.
authors.forename: Zhao
authors.initials: Z
authors.lastname: Wu
authors.affiliation: Key Laboratory of Advanced Materials of Ministry of Education of China, School of Materials Science and Engineering, Tsinghua University, Beijing, China.
authors.forename: Xiao-Dan
authors.identifier: 0000-0002-5210-128X
authors.initials: XD
authors.lastname: Sun
authors.affiliation: Institute of Orthopedics, Chinese PLA General Hospital, Beijing, China; The Neural Regeneration Co-innovation Center of Jiangsu Province, Nantong, Jiangsu Province, China.
authors.forename: Jiang
authors.identifier: 0000-0003-4662-9288
authors.initials: J
authors.lastname: Peng
keywords: Schwann cells; conductivity; electrical property; electrospinning; human umbilical cord mesenchymal stem cells; nanofibrous scaffolds; nerve regeneration; nerve tissue engineering; neural regeneration; polypyrrole