title: Subtraction-based approach for enhancing the depth sensitivity of time-resolved NIRS.
abstract: The aim of this study was to evaluate enhancing of the depth sensitivity of time-resolved near-infrared spectroscopy with a subtraction-based approach. Due to the complexity of light propagation in a heterogeneous media, and to prove the validity of the proposed method in a heterogeneous turbid media we conducted a broad analysis taking into account a number of parameters related to the method as well as various parameters of this media. The results of these experiments confirm that the depth sensitivity of the subtraction-based approach is better than classical approaches using continuous-wave or time-resolved methods. Furthermore, the results showed that the subtraction-based approach has a unique, selective sensitivity to a layer at a specific depth.In vivoapplication of the proposed method resulted in a greater magnitude of the hemodynamic changes during functional activation than with the standard approach.
authors.affiliation: Department of Medical Biophysics, Western University, London, ON, Canada; Imaging Division, Lawson Health Research Institute, London, ON, Canada.
authors.forename: Daniel
authors.initials: D
authors.lastname: Milej
authors.affiliation: Department of Medical Biophysics, Western University, London, ON, Canada; Imaging Division, Lawson Health Research Institute, London, ON, Canada.
authors.forename: Androu
authors.initials: A
authors.lastname: Abdalmalak
authors.affiliation: Department of Medical Biophysics, Western University, London, ON, Canada; Imaging Division, Lawson Health Research Institute, London, ON, Canada.
authors.forename: Peter
authors.initials: P
authors.lastname: McLachlan
authors.affiliation: Department of Medical Biophysics, Western University, London, ON, Canada; Imaging Division, Lawson Health Research Institute, London, ON, Canada.
authors.forename: Mamadou
authors.initials: M
authors.lastname: Diop
authors.affiliation: Nalecz Institute of Biocybernetics and Biomedical Engineering, Warsaw, Poland.
authors.forename: Adam
authors.initials: A
authors.lastname: Liebert
authors.affiliation: Department of Medical Biophysics, Western University, London, ON, Canada; Imaging Division, Lawson Health Research Institute, London, ON, Canada.
authors.forename: Keith
authors.initials: K
authors.lastname: St Lawrence
keywords: (160.4760) Optical properties; (170.3660) Light propagation in tissues; (170.6920) Time-resolved imaging; (170.7050) Turbid media