title: A common ancestral DNMT3A-mutated preleukemic clone giving rise to AML and MDS in an adolescent girl.
authors.affiliation: a Institute of Human Genetics , Hannover Medical School , Hannover , Germany.
authors.forename: Gudrun
authors.initials: G
authors.lastname: Göhring
authors.affiliation: a Institute of Human Genetics , Hannover Medical School , Hannover , Germany.
authors.forename: Kathrin
authors.initials: K
authors.lastname: Thomay
authors.affiliation: a Institute of Human Genetics , Hannover Medical School , Hannover , Germany.
authors.forename: Gunnar
authors.initials: G
authors.lastname: Schmidt
authors.affiliation: a Institute of Human Genetics , Hannover Medical School , Hannover , Germany.
authors.forename: Tim
authors.initials: T
authors.lastname: Ripperger
authors.affiliation: a Institute of Human Genetics , Hannover Medical School , Hannover , Germany.|b Manitoba Institute of Cell Biology , CancerCare Manitoba , Winnipeg , Canada.
authors.forename: Michael
authors.initials: M
authors.lastname: Xu
authors.affiliation: a Institute of Human Genetics , Hannover Medical School , Hannover , Germany.
authors.forename: Nicole
authors.initials: N
authors.lastname: Wittner
authors.affiliation: c Department of Pediatric Hematology and Oncology , Hannover Medical School , Hannover , Germany.
authors.forename: Mwe Mwe
authors.initials: MM
authors.lastname: Chao
authors.affiliation: d Department of Pathology , Clinical Center , Böblingen , Germany.
authors.forename: Irith
authors.initials: I
authors.lastname: Baumann
authors.affiliation: e Division of Pediatric Hematology and Oncology, Department of Pediatrics , University Medical Center Freiburg , Freiburg , Germany.
authors.forename: Marena
authors.initials: M
authors.lastname: Niewisch
authors.affiliation: f Clinic for Pediatrics III , University Hospital Essen , Essen , Germany.
authors.forename: Dirk
authors.initials: D
authors.lastname: Reinhardt
authors.affiliation: g Hospital for Children and Adolescents , University Hospital Frankfurt , Frankfurt , Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Klingebiel
authors.affiliation: h Department of Hematology, Hemostasis, Oncology and SCT , Hannover Medical School , Hannover , Germany.
authors.forename: Felicitas
authors.initials: F
authors.lastname: Thol
authors.affiliation: a Institute of Human Genetics , Hannover Medical School , Hannover , Germany.
authors.forename: Brigitte
authors.initials: B
authors.lastname: Schlegelberger
authors.affiliation: e Division of Pediatric Hematology and Oncology, Department of Pediatrics , University Medical Center Freiburg , Freiburg , Germany.
authors.forename: Charlotte M
authors.initials: CM
authors.lastname: Niemeyer
mesh_terms: D000293:Adolescent; D000483:Alleles; D015415:Biomarkers; D001853:Bone Marrow / Q000473:pathology; D060965:Clonal Evolution / Q000235:genetics*; D004248:DNA (Cytosine-5-)-Methyltransferases / Q000235:genetics*; D019175:DNA Methylation; D000090205:DNA Methyltransferase 3A; D004252:DNA Mutational Analysis; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis / Q000235:genetics*; D007958:Leukocyte Count; D009154:Mutation; D009190:Myelodysplastic Syndromes / Q000175:diagnosis / Q000235:genetics*; D011230:Precancerous Conditions / Q000235:genetics*
chemical_list: D015415:Biomarkers; C000717967:DNMT3A protein, human; D004248:DNA (Cytosine-5-)-Methyltransferases; D000090205:DNA Methyltransferase 3A