title: Increase in activity of Na+, K+-ATPase by Porphyrin compounds as treatment for Dysnatremias caused by Diabetes Mellitus.
abstract: OBJECTIVE
  The aim of this study was to test the action of Porphyrin compounds, Tetraphenylporphine sulfonate (TPPS), 5,10,15,20-Tetrakis (4-sulfonatophenyl) porphyrinato Iron(III) Chloride (FeTPPS) and 5,10,15,20-Tetrakis (4-sulfonatophenyl) porphyrinato Iron(III) nitrosyl Chloride (FeNOTPPS), on Na+, K+ -ATPase of cell membrane of erythrocytes.
  
  
  METHODS
  Enzymatic assays, measuring the amount of inorganic phosphate produced, were used to estimate the activity of Na+, K+-ATPase.
  
  
  RESULTS
  The results show that Porphyrin compounds exert an insulin-like effect on Na+, K+-ATPase. They act by increasing the activity of the membrane-bound enzyme.
  
  
  CONCLUSIONS
  All the three Porphyrin compounds increased the activity of erythrocyte Na+, K+-ATPase. The exact mechanism of action of these compounds is not clear.
authors.affiliation: Abdul Hai, Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, Northern Border University, Arar, Saudi Arabia.
authors.forename: Abdul
authors.initials: A
authors.lastname: Hai
authors.affiliation: Nadeem Kizilbash, Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, Northern Border University, Arar, Saudi Arabia.
authors.forename: Nadeem
authors.initials: N
authors.lastname: Kizilbash
keywords: 5,10,15,20-Tetrakis (4-sulfonatophenyl) porphyrinato Iron(III) Chloride (FeTPPS) and; 5,10,15,20-Tetrakis (4-sulfonatophenyl) porphyrinato Iron(III) nitrosyl Chloride (FeNOTPPS); Acetylcholinesterase; Acetylcholinesterase (AChE); Diabetes Mellitus; Dysnatremias; K+-ATPase; Na+; Porphyrin derivatives; Tetraphenylporphinesulfonate (TPPS)