title: InterPro in 2017-beyond protein family and domain annotations.
abstract: InterPro (http://www.ebi.ac.uk/interpro/) is a freely available database used to classify protein sequences into families and to predict the presence of important domains and sites. InterProScan is the underlying software that allows both protein and nucleic acid sequences to be searched against InterPro's predictive models, which are provided by its member databases. Here, we report recent developments with InterPro and its associated software, including the addition of two new databases (SFLD and CDD), and the functionality to include residue-level annotation and prediction of intrinsic disorder. These developments enrich the annotations provided by InterPro, increase the overall number of residues annotated and allow more specific functional inferences.
authors.affiliation: European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK rdf@ebi.ac.uk.
authors.forename: Robert D
authors.initials: RD
authors.lastname: Finn
authors.affiliation: School of Computer Science, University of Manchester, UK.
authors.forename: Teresa K
authors.initials: TK
authors.lastname: Attwood
authors.affiliation: Department of Bioengineering & Therapeutic Sciences, University of California, San Francisco, CA 94143, USA.
authors.forename: Patricia C
authors.initials: PC
authors.lastname: Babbitt
authors.affiliation: European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
authors.forename: Alex
authors.identifier: 0000-0002-6982-4660
authors.initials: A
authors.lastname: Bateman
authors.affiliation: European Molecular Biology Laboratory, Biocomputing, Meyerhofstasse 1, 69117 Heidelberg, Germany.
authors.forename: Peer
authors.initials: P
authors.lastname: Bork
authors.affiliation: Swiss-Prot Group, SIB Swiss Institute of Bioinformatics, CMU, 1 rue Michel-Servet, CH-1211 Geneva 4, Switzerland.
authors.forename: Alan J
authors.initials: AJ
authors.lastname: Bridge
authors.affiliation: European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
authors.forename: Hsin-Yu
authors.initials: HY
authors.lastname: Chang
authors.affiliation: MTA-ELTE Lendület Bioinformatics Research Group, Department of Biochemistry, Eötvös Loránd University, Pázmány Péter sétány 1/c, Budapest, Hungary.
authors.forename: Zsuzsanna
authors.initials: Z
authors.lastname: Dosztányi
authors.affiliation: European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
authors.forename: Sara
authors.initials: S
authors.lastname: El-Gebali
authors.affiliation: European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
authors.forename: Matthew
authors.initials: M
authors.lastname: Fraser
authors.affiliation: Computer Science department, University of Bristol, Woodland Road, Bristol BS8 1UB, UK.
authors.forename: Julian
authors.initials: J
authors.lastname: Gough
authors.affiliation: Bioinformatics Department, J. Craig Venter Institute, 9714 Medical Center Drive, Rockville, MD 20850, USA.
authors.forename: David
authors.initials: D
authors.lastname: Haft
authors.affiliation: Department of Bioengineering & Therapeutic Sciences, University of California, San Francisco, CA 94143, USA.
authors.forename: Gemma L
authors.identifier: 0000-0002-6731-6398
authors.initials: GL
authors.lastname: Holliday
authors.affiliation: Center for Bioinformatics and Computational Biology, University of Delaware, Newark, DE 19711, USA.
authors.forename: Hongzhan
authors.initials: H
authors.lastname: Huang
authors.affiliation: Division of Bioinformatics, Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90033, USA.
authors.forename: Xiaosong
authors.initials: X
authors.lastname: Huang
authors.affiliation: Biobyte Solutions GmbH, Bothestr. 142, 69126 Heidelberg, Germany.
authors.forename: Ivica
authors.initials: I
authors.lastname: Letunic
authors.affiliation: European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Lopez
authors.affiliation: National Center for Biotechnology Information, National Library of Medicine, NIH Bldg, 38A, 8600 Rockville Pike, Bethesda, MD 20894, USA.
authors.forename: Shennan
authors.initials: S
authors.lastname: Lu
authors.affiliation: National Center for Biotechnology Information, National Library of Medicine, NIH Bldg, 38A, 8600 Rockville Pike, Bethesda, MD 20894, USA.
authors.forename: Aron
authors.initials: A
authors.lastname: Marchler-Bauer
authors.affiliation: Division of Bioinformatics, Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90033, USA.
authors.forename: Huaiyu
authors.initials: H
authors.lastname: Mi
authors.affiliation: European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
authors.forename: Jaina
authors.initials: J
authors.lastname: Mistry
authors.affiliation: Georgetown University Medical Center, 3300 Whitehaven St, NW, Washington, DC 20007, USA.
authors.forename: Darren A
authors.initials: DA
authors.lastname: Natale
authors.affiliation: Department of Biomedical Sciences and CRIBI Biotech Center, University of Padua, via U. Bassi 58/b, 35131 Padua, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Necci
authors.affiliation: European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
authors.forename: Gift
authors.initials: G
authors.lastname: Nuka
authors.affiliation: Structural and Molecular Biology, University College London, Darwin Building, London WC1E 6BT, UK.
authors.forename: Christine A
authors.initials: CA
authors.lastname: Orengo
authors.affiliation: European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
authors.forename: Youngmi
authors.initials: Y
authors.lastname: Park
authors.affiliation: European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
authors.forename: Sebastien
authors.initials: S
authors.lastname: Pesseat
authors.affiliation: Department of Biomedical Sciences and CRIBI Biotech Center, University of Padua, via U. Bassi 58/b, 35131 Padua, Italy.
authors.forename: Damiano
authors.initials: D
authors.lastname: Piovesan
authors.affiliation: European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
authors.forename: Simon C
authors.initials: SC
authors.lastname: Potter
authors.affiliation: European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
authors.forename: Neil D
authors.initials: ND
authors.lastname: Rawlings
authors.affiliation: Swiss-Prot Group, SIB Swiss Institute of Bioinformatics, CMU, 1 rue Michel-Servet, CH-1211 Geneva 4, Switzerland.
authors.forename: Nicole
authors.initials: N
authors.lastname: Redaschi
authors.affiliation: European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
authors.forename: Lorna
authors.initials: L
authors.lastname: Richardson
authors.affiliation: Swiss-Prot Group, SIB Swiss Institute of Bioinformatics, CMU, 1 rue Michel-Servet, CH-1211 Geneva 4, Switzerland.
authors.forename: Catherine
authors.initials: C
authors.lastname: Rivoire
authors.affiliation: European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
authors.forename: Amaia
authors.initials: A
authors.lastname: Sangrador-Vegas
authors.affiliation: Swiss-Prot Group, SIB Swiss Institute of Bioinformatics, CMU, 1 rue Michel-Servet, CH-1211 Geneva 4, Switzerland.
authors.forename: Christian
authors.initials: C
authors.lastname: Sigrist
authors.affiliation: Structural and Molecular Biology, University College London, Darwin Building, London WC1E 6BT, UK.
authors.forename: Ian
authors.initials: I
authors.lastname: Sillitoe
authors.affiliation: Computer Science department, University of Bristol, Woodland Road, Bristol BS8 1UB, UK.
authors.forename: Ben
authors.identifier: 0000-0001-9508-8065
authors.initials: B
authors.lastname: Smithers
authors.affiliation: European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
authors.forename: Silvano
authors.initials: S
authors.lastname: Squizzato
authors.affiliation: Bioinformatics Department, J. Craig Venter Institute, 9714 Medical Center Drive, Rockville, MD 20850, USA.
authors.forename: Granger
authors.initials: G
authors.lastname: Sutton
authors.affiliation: National Center for Biotechnology Information, National Library of Medicine, NIH Bldg, 38A, 8600 Rockville Pike, Bethesda, MD 20894, USA.
authors.forename: Narmada
authors.initials: N
authors.lastname: Thanki
authors.affiliation: Division of Bioinformatics, Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90033, USA.
authors.forename: Paul D
authors.initials: PD
authors.lastname: Thomas
authors.affiliation: Department of Biomedical Sciences and CRIBI Biotech Center, University of Padua, via U. Bassi 58/b, 35131 Padua, Italy.|CNR Institute of Neuroscience, via U. Bassi 58/b, 35131 Padua, Italy.
authors.forename: Silvio C E
authors.identifier: 0000-0003-4525-7793
authors.initials: SC
authors.lastname: Tosatto
authors.affiliation: Center for Bioinformatics and Computational Biology, University of Delaware, Newark, DE 19711, USA.
authors.forename: Cathy H
authors.initials: CH
authors.lastname: Wu
authors.affiliation: Swiss-Prot Group, SIB Swiss Institute of Bioinformatics, CMU, 1 rue Michel-Servet, CH-1211 Geneva 4, Switzerland.
authors.forename: Ioannis
authors.initials: I
authors.lastname: Xenarios
authors.affiliation: Georgetown University Medical Center, 3300 Whitehaven St, NW, Washington, DC 20007, USA.
authors.forename: Lai-Su
authors.initials: LS
authors.lastname: Yeh
authors.affiliation: European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
authors.forename: Siew-Yit
authors.initials: SY
authors.lastname: Young
authors.affiliation: European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
authors.forename: Alex L
authors.initials: AL
authors.lastname: Mitchell
mesh_terms: D019295:Computational Biology / Q000379:methods*; D030562:Databases, Protein; D006801:Humans; D058977:Molecular Sequence Annotation; D010802:Phylogeny; D054730:Protein Interaction Domains and Motifs; D012984:Software