title: Some biological activities of pigments extracted from Micrococcus roseus (PTCC 1411) and Rhodotorula glutinis (PTCC 5257).
abstract: The importance of replacing synthetic pigments with natural types is increasing day by day in the food industry due to the harmful effects of some synthetic pigments. Microorganisms are a major source of natural pigments, which nowadays have attracted the attention of researchers. In this study, carotenoid pigments were produced by Micrococcus roseus and Rhodotorula glutinis, and some of their biological properties such as antimicrobial, antioxidant, anticancer, and anti-inflammatory activities were evaluated. Given the results, bacteria, especially gram-positive bacteria, had higher sensitivity to the pigments extracted from M. roseus (PEM) and R. glutinis (PER) compared to molds so that Bacillus cereus and Alternaria citri had the highest and the lowest sensitivity, respectively. PER showed a higher antioxidant activity compared with PEM in the various methods of measuring antioxidant activity. In vitro and in vivo anti-tumor-promoting activities of PER were measured significantly more than PEM (P <0.05). Both pigment extracts remarkably inhibited the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation, so that ID50(50% inhibitory dose) of PEM and PER were 0.22 and 0.09 mg/ear, respectively.
authors.affiliation: Health Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
authors.forename: Hossein
authors.initials: H
authors.lastname: Rostami
authors.affiliation: Department of Food Hygiene, Faculty of Medical Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran.
authors.forename: Hassan
authors.initials: H
authors.lastname: Hamedi
authors.affiliation: Department of Food Science and Technology, Gorgan University of Agriculture and Natural Resources, Gorgan, Iran Mahmud.yolmeh@yahoo.com.
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Yolmeh
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology; D002338:Carotenoids / Q000737:chemistry / Q000494:pharmacology; D051379:Mice; D008837:Micrococcus / Q000737:chemistry*; D010860:Pigments, Biological / Q000737:chemistry* / Q000494:pharmacology*; D012248:Rhodotorula / Q000737:chemistry*
chemical_list: D000890:Anti-Infective Agents; D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D000975:Antioxidants; D010860:Pigments, Biological; D002338:Carotenoids
keywords: Micrococcus roseus; Rhodotorula glutinis; biological activities; pigment