title: Distribution of As, Cd, and Pb in seafood in Southern China and their oral bioavailability in mice.
abstract: The distribution of the toxic elements As, Cd, and Pb in nine different types of seafood from Shenzhen, China, was investigated by using inductively coupled plasma mass spectrometry (ICP-MS). The results revealed that the concentrations of arsenic (As) in fish (Lutjanus erythropterus, Paralichthys olivaceus) and in bivalve (Meretrix meretrix) and cadmium (Cd) in scallop (Argopecten irradians) exceed the limits established by food safety regulations in China and EU (European Union). Furthermore, the bioavailability of As, Cd, and lead (Pb) in mice after 20-day oral ingestion of Crassostrea rivularis was investigated, and the total rate of absorption of toxic elements in samples from the liver and kidney tissues and blood was determined. The results of this in vivo trial indicated that the oral bioavailability of As, Cd, and Pb was approximately 0.33, 0.45, and 0.74%, respectively.
authors.affiliation: College of Physics and Energy, Shenzhen University, Shenzhen, 518060, China.
authors.forename: Zhi-Peng
authors.initials: ZP
authors.lastname: Zhu
authors.affiliation: College of Physics and Energy, Shenzhen University, Shenzhen, 518060, China. yongpeng@szu.edu.cn.
authors.forename: Yong-Peng
authors.initials: YP
authors.lastname: Tong
authors.affiliation: College of Chemistry and Environment Engineering, Shenzhen University, Shenzhen, 518060, China.
authors.forename: Wei-Yang
authors.initials: WY
authors.lastname: Tang
authors.affiliation: College of Physics, Jilin University, Changchun, 130012, China.
authors.forename: Zheng-Xin
authors.initials: ZX
authors.lastname: Wu
authors.affiliation: College of Life Sciences, Shenzhen University, Shenzhen, 518060, China.
authors.forename: Zhi-Bing
authors.initials: ZB
authors.lastname: Wu
mesh_terms: D000818:Animals; D001151:Arsenic / Q000032:analysis* / Q000493:pharmacokinetics; D001682:Biological Availability; D002104:Cadmium / Q000032:analysis* / Q000493:pharmacokinetics; D002681:China; D005260:Female; D007854:Lead / Q000032:analysis* / Q000493:pharmacokinetics; D051379:Mice; D008807:Mice, Inbred BALB C; D017747:Seafood / Q000032:analysis*
chemical_list: D002104:Cadmium; D007854:Lead; D001151:Arsenic
keywords: Dose response; Oral bioavailability; Seafood; Toxic elements