title: Drug discovery beyond the rule of 5 - Opportunities and challenges.
authors.affiliation: a Department of Medicinal Chemistry, MIPS , Monash University , Parkville , Victoria , Australia.
authors.forename: Bradley C
authors.initials: BC
authors.lastname: Doak
authors.affiliation: b Department of Chemistry - BMC , Uppsala University , Uppsala , Sweden.
authors.forename: Jan
authors.initials: J
authors.lastname: Kihlberg
mesh_terms: D016503:Drug Delivery Systems; D015195:Drug Design; D055808:Drug Discovery / Q000379:methods*; D006801:Humans; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000737:chemistry
chemical_list: D004364:Pharmaceutical Preparations
keywords: Beyond rule of 5; conformational flexibility; difficult target; macrocycle; oral absorption