title: Inhibition of Alzheimer amyloid β aggregation by polyvalent trehalose.
abstract: A glycopolymer carrying trehalose was found to suppress the formation of amyloid fibrils from the amyloid β peptide (1-42) (Aβ), as evaluated by thioflavin T assay and atomic force microscopy. Glycopolymers carrying sugar alcohols also changed the aggregation properties of Aβ, and the inhibitory effect depended on the type of sugar and alkyl side chain. Neutralization activity was confirmed byin vitroassay using HeLa cells. The glycopolymer carrying trehalose strongly inhibited amyloid formation and neutralized cytotoxicity.
authors.affiliation: School of Materials Science, Japan Advanced Institute of Science and Technology, 1-1 Asahidai,Nomi, Ishikawa 923-1292, Japan; Department of Molecular Design and Engineering, Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan.
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Miura
authors.affiliation: School of Materials Science, Japan Advanced Institute of Science and Technology, 1-1 Asahidai,Nomi, Ishikawa 923-1292, Japan.
authors.forename: Chouga
authors.initials: C
authors.lastname: You
authors.affiliation: Department of Molecular Design and Engineering, Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan.
authors.forename: Reiko
authors.initials: R
authors.lastname: Ohnishi
keywords: amphiphilicity; amyloid; glycopolymer; multivalent effect