title: The molecular pathogenesis of mantle cell lymphoma.
abstract: Mantle cell lymphoma (MCL) is characterized by the translocation t(11;14) leading to constitutive cyclin D1 overexpression. However, overexpression of cyclin D1 alone is insufficient to cause malignant transformation. Secondary genetic alterations and deregulated signaling pathways involved in DNA damage response, cell proliferation, and apoptosis are indispensable for MCL lymphomagenesis. Recent studies investigating the biology of MCL have revealed crucial importance of B-cell receptor (BCR), nuclear factor-kappa B (NF-κB), phosphoinositide 3-kinase (PI3K), and BCL2 signaling for the molecular pathogenesis of MCL. In addition, activation of the Janus kinase (JAK)/signal transducer and activator of transcription 3 (STAT3), NOTCH and WNT pathway can be observed in subsets of MCLs. These addictions can potentially be utilized therapeutically by implementing small molecule inhibitors into current treatment regimens.
authors.affiliation: a Department of Translational Oncology , University Hospital Münster , Münster , Germany.|b Department of Medicine A, Hematology, Oncology and Pneumology , University Hospital Münster , Münster , Germany.
authors.forename: Niklas
authors.initials: N
authors.lastname: Vogt
authors.affiliation: a Department of Translational Oncology , University Hospital Münster , Münster , Germany.|c Cluster of Excellence , Deutsche Forschungsgemeinschaft EXC 1003, Cells in Motion , Münster , Germany.
authors.forename: Beiying
authors.initials: B
authors.lastname: Dai
authors.affiliation: a Department of Translational Oncology , University Hospital Münster , Münster , Germany.|c Cluster of Excellence , Deutsche Forschungsgemeinschaft EXC 1003, Cells in Motion , Münster , Germany.
authors.forename: Tabea
authors.initials: T
authors.lastname: Erdmann
authors.affiliation: b Department of Medicine A, Hematology, Oncology and Pneumology , University Hospital Münster , Münster , Germany.|c Cluster of Excellence , Deutsche Forschungsgemeinschaft EXC 1003, Cells in Motion , Münster , Germany.
authors.forename: Wolfgang E
authors.initials: WE
authors.lastname: Berdel
authors.affiliation: a Department of Translational Oncology , University Hospital Münster , Münster , Germany.|b Department of Medicine A, Hematology, Oncology and Pneumology , University Hospital Münster , Münster , Germany.|c Cluster of Excellence , Deutsche Forschungsgemeinschaft EXC 1003, Cells in Motion , Münster , Germany.
authors.forename: Georg
authors.initials: G
authors.lastname: Lenz
mesh_terms: D000818:Animals; D015415:Biomarkers; D019938:Cyclin D1 / Q000235:genetics / Q000378:metabolism; D018450:Disease Progression; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D014644:Genetic Variation; D006801:Humans; D020522:Lymphoma, Mantle-Cell / Q000188:drug therapy / Q000209:etiology* / Q000378:metabolism*; D058990:Molecular Targeted Therapy; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D015415:Biomarkers; C530104:CCND1 protein, human; D019938:Cyclin D1
keywords: Mantle cell lymphoma; molecular pathogenesis; translocation