title: Phenotypic screening meets natural products in drug discovery.
abstract: The Nobel Prize in Physiology or Medicine 2015 was awarded for discoveries related to the control of parasitic diseases using natural products of microbial and plant origin. In current drug discovery programs, synthesized compounds are widely used as a screening source; however, this award reminds us of the importance of natural products. Here, we introduce our phenotypic screening methods based on changes in cell morphology and discuss their effectiveness and impact for natural products in drug discovery.
authors.affiliation: a Chemical Biology Research Group , RIKEN Center for Sustainable Resource Science , Saitama , Japan.
authors.forename: Yushi
authors.initials: Y
authors.lastname: Futamura
authors.affiliation: a Chemical Biology Research Group , RIKEN Center for Sustainable Resource Science , Saitama , Japan.
authors.forename: Kai
authors.initials: K
authors.lastname: Yamamoto
authors.affiliation: a Chemical Biology Research Group , RIKEN Center for Sustainable Resource Science , Saitama , Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Osada
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000494:pharmacology; D001681:Biological Assay; D001688:Biological Products / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D010641:Phenotype
chemical_list: D000935:Antifungal Agents; D000970:Antineoplastic Agents; D001688:Biological Products