title: Mesoporous nanospheres functionalized optical microfiber biosensor for low concentration neurotransmitter detection.
abstract: A label-free and ultrasensitive microfiber interferometer biosensor has been demonstrated for detection of neurotransmitter molecule (5-HT). The surface morphology of the silicon dioxide nanospheres acting as molecule sieve provides an effective mean of gathering 5-HT molecules by designed mesoporous structure. The slight concentration change of 5-HT molecules is translated into a dramatic wavelength shift of the interferometric fringe pattern. The experimental results show that the biosensor has a linear response in concentration range from 100 fM to 1 µM and a detection limit as low as 84 fM.
authors.forename: Mingfei
authors.initials: M
authors.lastname: Ding
authors.forename: Yunyun
authors.initials: Y
authors.lastname: Huang
authors.forename: Tuan
authors.initials: T
authors.lastname: Guo
authors.forename: Li-Peng
authors.initials: LP
authors.lastname: Sun
authors.forename: Bai-Ou
authors.initials: BO
authors.lastname: Guan
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation*; D004867:Equipment Design; D007368:Interferometry; D054118:Nanospheres; D018377:Neurotransmitter Agents; D012701:Serotonin / Q000032:analysis*; D012825:Silicon / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry
chemical_list: D018377:Neurotransmitter Agents; D012701:Serotonin; D012822:Silicon Dioxide; D012825:Silicon