title: The Zebrafish Model Organism Database: new support for human disease models, mutation details, gene expression phenotypes and searching.
abstract: The Zebrafish Model Organism Database (ZFIN; http://zfin.org) is the central resource for zebrafish (Danio rerio) genetic, genomic, phenotypic and developmental data. ZFIN curators provide expert manual curation and integration of comprehensive data involving zebrafish genes, mutants, transgenic constructs and lines, phenotypes, genotypes, gene expressions, morpholinos, TALENs, CRISPRs, antibodies, anatomical structures, models of human disease and publications. We integrate curated, directly submitted, and collaboratively generated data, making these available to zebrafish research community. Among the vertebrate model organisms, zebrafish are superbly suited for rapid generation of sequence-targeted mutant lines, characterization of phenotypes including gene expression patterns, and generation of human disease models. The recent rapid adoption of zebrafish as human disease models is making management of these data particularly important to both the research and clinical communities. Here, we describe recent enhancements to ZFIN including use of the zebrafish experimental conditions ontology, 'Fish' records in the ZFIN database, support for gene expression phenotypes, models of human disease, mutation details at the DNA, RNA and protein levels, and updates to the ZFIN single box search.
authors.affiliation: The Institute of Neuroscience, University of Oregon, Eugene, OR 97403-1254, USA dhowe@zfin.org.
authors.forename: Douglas G
authors.initials: DG
authors.lastname: Howe
authors.affiliation: The Institute of Neuroscience, University of Oregon, Eugene, OR 97403-1254, USA.
authors.forename: Yvonne M
authors.initials: YM
authors.lastname: Bradford
authors.affiliation: The Institute of Neuroscience, University of Oregon, Eugene, OR 97403-1254, USA.
authors.forename: Anne
authors.initials: A
authors.lastname: Eagle
authors.affiliation: The Institute of Neuroscience, University of Oregon, Eugene, OR 97403-1254, USA.
authors.forename: David
authors.initials: D
authors.lastname: Fashena
authors.affiliation: The Institute of Neuroscience, University of Oregon, Eugene, OR 97403-1254, USA.
authors.forename: Ken
authors.initials: K
authors.lastname: Frazer
authors.affiliation: The Institute of Neuroscience, University of Oregon, Eugene, OR 97403-1254, USA.
authors.forename: Patrick
authors.initials: P
authors.lastname: Kalita
authors.affiliation: The Institute of Neuroscience, University of Oregon, Eugene, OR 97403-1254, USA.
authors.forename: Prita
authors.initials: P
authors.lastname: Mani
authors.affiliation: The Institute of Neuroscience, University of Oregon, Eugene, OR 97403-1254, USA.
authors.forename: Ryan
authors.initials: R
authors.lastname: Martin
authors.affiliation: The Institute of Neuroscience, University of Oregon, Eugene, OR 97403-1254, USA.
authors.forename: Sierra Taylor
authors.initials: ST
authors.lastname: Moxon
authors.affiliation: The Institute of Neuroscience, University of Oregon, Eugene, OR 97403-1254, USA.
authors.forename: Holly
authors.initials: H
authors.lastname: Paddock
authors.affiliation: The Institute of Neuroscience, University of Oregon, Eugene, OR 97403-1254, USA.
authors.forename: Christian
authors.initials: C
authors.lastname: Pich
authors.affiliation: The Institute of Neuroscience, University of Oregon, Eugene, OR 97403-1254, USA.
authors.forename: Sridhar
authors.initials: S
authors.lastname: Ramachandran
authors.affiliation: The Institute of Neuroscience, University of Oregon, Eugene, OR 97403-1254, USA.
authors.forename: Leyla
authors.initials: L
authors.lastname: Ruzicka
authors.affiliation: The Institute of Neuroscience, University of Oregon, Eugene, OR 97403-1254, USA.
authors.forename: Kevin
authors.initials: K
authors.lastname: Schaper
authors.affiliation: The Institute of Neuroscience, University of Oregon, Eugene, OR 97403-1254, USA.
authors.forename: Xiang
authors.initials: X
authors.lastname: Shao
authors.affiliation: The Institute of Neuroscience, University of Oregon, Eugene, OR 97403-1254, USA.
authors.forename: Amy
authors.initials: A
authors.lastname: Singer
authors.affiliation: The Institute of Neuroscience, University of Oregon, Eugene, OR 97403-1254, USA.
authors.forename: Sabrina
authors.initials: S
authors.lastname: Toro
authors.affiliation: The Institute of Neuroscience, University of Oregon, Eugene, OR 97403-1254, USA.
authors.forename: Ceri
authors.initials: C
authors.lastname: Van Slyke
authors.affiliation: The Institute of Neuroscience, University of Oregon, Eugene, OR 97403-1254, USA.
authors.forename: Monte
authors.initials: M
authors.lastname: Westerfield
mesh_terms: D000818:Animals; D019295:Computational Biology / Q000379:methods; D066289:Data Curation; D030541:Databases, Genetic; D004195:Disease Models, Animal; D015870:Gene Expression; D056726:Genetic Association Studies / Q000379:methods*; D020022:Genetic Predisposition to Disease; D023281:Genomics / Q000379:methods*; D005838:Genotype; D006801:Humans; D009154:Mutation; D010641:Phenotype; D057386:Search Engine; D015027:Zebrafish / Q000235:genetics*