title: Erasing Borders: A Brief Chronicle of Early Synthetic Biology.
abstract: Synthetic Biology is currently presented as an emergent field involving the application of engineering principles to living matter. However, the scientific pursuit of making life in a laboratory is not new and has been the ultimate, if somewhat distant, aim of the origin-of-life research program for many years. Actually, over a century ago, the idea that the synthesis of life was indispensable to fully understand its nature already appealed to material scientists and evolutionists alike. Jacques Loeb proposed a research program from an engineering standpoint, following a synthetic method (experimental abiogenesis) and based on his mechanist vision of living beings, which he considered true chemical machines. Early synthetic biology endeavors, such as the premature experiments by Alfonso L. Herrera in Mexico, Stéphane Leduc in France, and John B. Burke in United Kingdom, were easily ridiculed on both scientific and ideological grounds. However, in retrospect, all those attempts should be considered as legitimate and sincere anti-vitalistic efforts to cross the apparent border between inert and living matter.
authors.affiliation: Department of Biochemistry and Molecular Biology and Institute for Integrative Systems Biology (I2SysBio, Universitat de València-CSIC), Universitat de València (Spain), C. Jose Beltran 2, 46980, Paterna, Spain. pereto@uv.es.
authors.forename: Juli
authors.identifier: http://orcid.org/0000-0002-5756-1517
authors.initials: J
authors.lastname: Peretó
mesh_terms: D001695:Biology; D049672:History, 19th Century; D049673:History, 20th Century; D006801:Humans; D008967:Molecular Biology; D058615:Synthetic Biology
keywords: Artificial life; Colloid chemistry; Osmotic growths; Plasmogeny; Radiobe; Sulphobe