title: Broad-spectrum antiviral properties of andrographolide.
abstract: Andrographolide, a diterpenoid, is known for its anti-inflammatory effects. It can be isolated from various plants of the genus Andrographis, commonly known as 'creat'. This purified compound has been tested for its anti-inflammatory effects in various stressful conditions, such as ischemia, pyrogenesis, arthritis, hepatic or neural toxicity, carcinoma, and oxidative stress, Apart from its anti-inflammatory effects, andrographolide also exhibits immunomodulatory effects by effectively enhancing cytotoxic T cells, natural killer (NK) cells, phagocytosis, and antibody-dependent cell-mediated cytotoxicity (ADCC). All these properties of andrographolide form the foundation for the use of this miraculous compound to restrain virus replication and virus-induced pathogenesis. The present article covers antiviral properties of andrographolide in variety of viral infections, with the hope of developing of a new highly potent antiviral drug with multiple effects.
authors.affiliation: Immunomodulation Laboratory, Defence Institute of Physiology and Allied Sciences, Lucknow Road, Timarpur, Delhi, 110054, India.
authors.forename: Swati
authors.initials: S
authors.lastname: Gupta
authors.affiliation: Immunomodulation Laboratory, Defence Institute of Physiology and Allied Sciences, Lucknow Road, Timarpur, Delhi, 110054, India. kpmpgi@rediffmail.com.
authors.forename: K P
authors.initials: KP
authors.lastname: Mishra
authors.affiliation: Immunomodulation Laboratory, Defence Institute of Physiology and Allied Sciences, Lucknow Road, Timarpur, Delhi, 110054, India.
authors.forename: Lilly
authors.initials: L
authors.lastname: Ganju
mesh_terms: D035685:Andrographis / Q000737:chemistry*; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D004224:Diterpenes / Q000494:pharmacology*; D006801:Humans; D018384:Oxidative Stress; D010936:Plant Extracts / Q000494:pharmacology*; D014777:Virus Diseases / Q000188:drug therapy / Q000821:virology*; D014780:Viruses / Q000187:drug effects*
chemical_list: D000998:Antiviral Agents; D004224:Diterpenes; D010936:Plant Extracts; C030419:andrographolide