title: Application of Research Domain Criteria to childhood and adolescent impulsive and addictive disorders: Implications for treatment.
abstract: The Research Domain Criteria (RDoC) initiative provides a large-scale, dimensional framework for the integration of research findings across traditional diagnoses, with the long-term aim of improving existing psychiatric treatments. A neurodevelopmental perspective is essential to this endeavor. However, few papers synthesizing research findings across childhood and adolescent disorders exist. Here, we discuss how the RDoC framework may be applied to the study of childhood and adolescent impulsive and addictive disorders in order to improve neurodevelopmental understanding and to enhance treatment development. Given the large scope of RDoC, we focus on a single construct highly relevant to addictive and impulsive disorders - initial responsiveness to reward attainment. Findings from genetic, molecular, neuroimaging and other translational research methodologies are highlighted.
authors.affiliation: Department of Psychiatry, Yale University School of Medicine, New Haven, CT, United States; The National Center on Addiction and Substance Abuse, Yale University School of Medicine, New Haven, CT, United States.
authors.forename: Sarah W
authors.initials: SW
authors.lastname: Yip
authors.affiliation: Department of Psychiatry, Yale University School of Medicine, New Haven, CT, United States; The National Center on Addiction and Substance Abuse, Yale University School of Medicine, New Haven, CT, United States; Child Study Center, Yale University School of Medicine, New Haven, CT, United States; Department of Neurobiology, Yale University School of Medicine, New Haven, CT, United States. Electronic address: marc.potenza@yale.edu.
authors.forename: Marc N
authors.initials: MN
authors.lastname: Potenza
mesh_terms: D000293:Adolescent; D016739:Behavior, Addictive / Q000175:diagnosis* / Q000523:psychology / Q000628:therapy; D002648:Child; D006801:Humans; D007175:Impulsive Behavior / Q000502:physiology*
keywords: Development; Dopamine; Impulsivity; Reward sensitivity; Substance use; fMRI