title: Clinical effects of joint application of β-sodium aescinate and mannitol in treating early swelling after upper limb trauma surgery.
abstract: The aim of the present study was to examine the clinical merits of joint application of β-sodium aescinate and mannitol for the treatment of early swelling of upper limb trauma after surgery. We verified whether the expression of serum aquaporin 1 (AQP-1) was involved in swelling mechanism. A total of 102 patients with swelling after upper limb trauma surgery were enrolled into the study and divided randomly into 3 groups (n=34 cases per group). Group A was treated with β-sodium aescinate; group B was treated with with mannitol and group C was treated with both β-sodium aescinate and mannitol. The expression level of AQP-1, and clinical effects and complications before and after treatment were compared§. The time of swelling subsidence in group C was significantly shorter than that of the other two groups and differences were statistically significant (P<0.05). The recovery ratio and total efficiency in group C were significantly higher than those in other two groups and differences were statistically significant (P<0.05). Three and seven days after treatment, the AQP-1 levels in group A and group C were decreased and AQP-1 level decreased further with time. Differences of comparison within groups were statistically significant (P<0.05), although the differences of comparison between the groups showed no statistical significance (P>0.05). We also compared the AQP-1 level in group B before and after treatment, and the differences were not statistically significant (P>0.05). When the complication incidence in the 3 groups was compared, no statistical significance was detected (P>0.05). We concluded that the joint use of β-sodium aescinate and mannitol in treating early swelling after upper limb trauma surgery produced satisfactory outcomes. This might be related to reduction of the AQP-1 level.
authors.affiliation: Department of Orthopeadic Surgery, The Third People's Hospital of Qingdao, Qingdao, Shandong 266041, P.R. China.
authors.forename: Bin
authors.initials: B
authors.lastname: Wang
authors.affiliation: Department of Orthopeadic Surgery, The Third People's Hospital of Qingdao, Qingdao, Shandong 266041, P.R. China.
authors.forename: Ruixiang
authors.initials: R
authors.lastname: Yang
authors.affiliation: Department of Hospital Infection-Control, The Third People's Hospital of Qingdao, Qingdao, Shandong 266041, P.R. China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Ju
authors.affiliation: Patient Service Center, The Third People's Hospital of Qingdao, Qingdao, Shandong 266041, P.R. China.
authors.forename: Shaofeng
authors.initials: S
authors.lastname: Liu
authors.affiliation: Department of Orthopeadic Surgery, The Third People's Hospital of Qingdao, Qingdao, Shandong 266041, P.R. China.
authors.forename: Yongchun
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Orthopeadic Surgery, The Third People's Hospital of Qingdao, Qingdao, Shandong 266041, P.R. China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Ma
keywords: mannitol; serum aquaporin 1; β-sodium aescinate