title: Oncogenic KRAS and the EGFR loop in pancreatic carcinogenesis-A connection to licensing nodes.
abstract: EGFR signaling has a critical role in oncogenic KRAS-driven tumorigenesis of the pancreas, whereas it is dispensable in other organs. The complex signaling network engaged by oncogenic KRAS and its modulation by EGFR signaling, remains incompletely understood. In order to study early signaling events activated by oncogenic KRAS in the pancreas, we recently developed a novel model system based on murine primary pancreatic epithelial cells enabling the time-specific expression of mutant KrasG12Dfrom its endogenous promoter. Here, we discuss our findings of a KrasG12D-induced autocrine EGFR loop, how this loop is integrated by the MYC oncogene, and point to possible translational implications.
authors.affiliation: a II. Medizinische Klinik, Klinikum rechts der Isar, Technische Universität München , München , Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Schneeweis
authors.affiliation: a II. Medizinische Klinik, Klinikum rechts der Isar, Technische Universität München , München , Germany.
authors.forename: Matthias
authors.initials: M
authors.lastname: Wirth
authors.affiliation: a II. Medizinische Klinik, Klinikum rechts der Isar, Technische Universität München , München , Germany.|b German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK) , Heidelberg , Germany.
authors.forename: Dieter
authors.initials: D
authors.lastname: Saur
authors.affiliation: a II. Medizinische Klinik, Klinikum rechts der Isar, Technische Universität München , München , Germany.
authors.forename: Maximilian
authors.initials: M
authors.lastname: Reichert
authors.affiliation: a II. Medizinische Klinik, Klinikum rechts der Isar, Technische Universität München , München , Germany.|b German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK) , Heidelberg , Germany.
authors.forename: Günter
authors.initials: G
authors.lastname: Schneider
mesh_terms: D000818:Animals; D019898:Autocrine Communication; D063646:Carcinogenesis; D066246:ErbB Receptors / Q000378:metabolism*; D006801:Humans; D010190:Pancreatic Neoplasms / Q000378:metabolism / Q000473:pathology; D016283:Proto-Oncogene Proteins p21(ras) / Q000378:metabolism*
chemical_list: D066246:ErbB Receptors; D016283:Proto-Oncogene Proteins p21(ras)
keywords: EGFR; MYC; autocrine signaling; kras; pancreatic cancer