title: Management of phosphorus load in CKD patients.
abstract: Disturbances in mineral and bone metabolism play a critical role in the pathogenesis of cardiovascular complications in patients with chronic kidney disease (CKD). The term "renal osteodystrophy" has recently been replaced with "CKD-mineral and bone disorder (CKD-MBD)", which includes vascular calcification as well as bone abnormalities. In Japan, proportions of the aged and long-term dialysis patients are increasing which makes management of vascular calcification and parathyroid function increasingly more important. There are three main strategies to manage phosphate load: phosphorus dietary restriction, administration of phosphate binder and to ensure in the CKD 5D setting, an adequate dialysis.
authors.affiliation: Department of Clinical Nutrition and Food Management, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Taketani
authors.affiliation: Division of Nephrology, Department of Medicine, Showa University Fujigaoka Hospital, Yokohama, Japan.
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Koiwa
authors.affiliation: Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, 3-25-8 Nishi-Shinbashi, Minato-ku, Tokyo, 105-8461, Japan. keitaro@jikei.ac.jp.
authors.forename: Keitaro
authors.identifier: http://orcid.org/0000-0002-6122-592X
authors.initials: K
authors.lastname: Yokoyama
mesh_terms: D000818:Animals; D001851:Bone Diseases, Metabolic / Q000628:therapy; D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000178:diet therapy / Q000378:metabolism* / Q000628:therapy*; D006801:Humans; D054559:Hyperphosphatemia / Q000150:complications / Q000628:therapy; D008903:Minerals / Q000378:metabolism; D010758:Phosphorus / Q000378:metabolism*; D016226:Phosphorus, Dietary / Q000378:metabolism; D051436:Renal Insufficiency, Chronic / Q000178:diet therapy / Q000378:metabolism* / Q000628:therapy*
chemical_list: D008903:Minerals; D016226:Phosphorus, Dietary; D010758:Phosphorus
keywords: CKD-MBD; Dietary management; Phosphate binder; Phosphorus