title: Treatment Emergent Agranulocytosis with Skin and Gingival Lesions in a Chronic Lymphocytic Leukemia Patient: A Case Report.
abstract: Chronic Lymphocytic Leukaemia (CLL) is a monoclonal lymphoid malignancy characterized by progressive accumulation of small, mature but functionally incompetent neoplastic lymphocytes in the peripheral blood, bone marrow and lymphoid organs. Patients present a variable course and may not require early intervention unlike other malignancies. Patients with rapidly deteriorating blood counts, and organomegaly need treatment. Alkylating agent live Bendamustine combined with Rituximab, anti-CD 20 monoclonal antibody have shown promising results in such patients. Anaemia, neutropenia and thrombocytopenia have been reported as treatment emergent events with this combination therapy. Neutrophils are the major innate defense and their depletion can result in a wide range of opportunistic infections. This case report discusess the oral and dermal lesions which emerged with the Rituximab and Bendamustine combination therapy in a patient with CLL and their management.
authors.affiliation: Professor, Department of Periodontology, Chhattisgarh Dental College and Research Institute , Rajnandgaon, Chhattisgarh, India .
authors.forename: Ramesh
authors.initials: R
authors.lastname: Amirisetty
authors.affiliation: Lecturer, Department of Periodontology, Chhattisgarh Dental College and Research Institute , Rajnandgaon, Chhattisgarh, India .
authors.forename: Varun
authors.initials: V
authors.lastname: Zade
authors.affiliation: Lecturer, Department of Periodontology, Chhattisgarh Dental College and Research Institute , Rajnandgaon, Chhattisgarh, India .
authors.forename: Meenakshi
authors.initials: M
authors.lastname: Boddun
authors.affiliation: Reader, Department of Oral Pathology and Microbiology, Chhattisgarh Dental College and Research Institute , Rajnandgaon, Chhattisgarh, India .
authors.forename: Rolly
authors.initials: R
authors.lastname: Gupta
authors.affiliation: Postgraduate Student, Department of Periodontology, Chhattisgarh Dental College and Research Institute , Rajnandgaon, Chhattisgarh, India .
authors.forename: Micky
authors.initials: M
authors.lastname: Kumari
authors.affiliation: Professor and Head, Department of Oral Pathology and Microbiology, Chhattisgarh Dental College and Research Institute , Rajnandgaon, Chhattisgarh, India .
authors.forename: Hema
authors.initials: H
authors.lastname: Suryawanshi
keywords: Bendamustine; Gingival necrosis; Neutropenia; Rituximab