title: CB-Receptor Agonist HU-210 Mimics the Postconditioning Phenomenon of Isolated Heart.
abstract: CB receptor agonist HU-210 exhibits an infarction-limiting effect during in vitro reperfusion of the heart after focal ischemia. This effect is paralleled by a decrease in left-ventricular developed pressure and double product. In addition, HU-210 reduces end-diastolic pressure during the reperfusion period, which indirectly attests to reduced Ca2+overload of cardiomyocytes.
authors.affiliation: Research Institute for Cardiology, Tomsk, Russia.
authors.forename: A S
authors.initials: AS
authors.lastname: Gorbunov
authors.affiliation: Research Institute for Cardiology, Tomsk, Russia. maslov@cardio-tomsk.ru.
authors.forename: L N
authors.initials: LN
authors.lastname: Maslov
authors.affiliation: Research Institute for Cardiology, Tomsk, Russia.
authors.forename: S Yu
authors.initials: SY
authors.lastname: Tsibulnikov
authors.affiliation: Research Institute for Cardiology, Tomsk, Russia.
authors.forename: I G
authors.initials: IG
authors.lastname: Khaliulin
authors.affiliation: Research Institute for Cardiology, Tomsk, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Tsepokina
authors.affiliation: Research Institute for Cardiology, Tomsk, Russia.
authors.forename: M V
authors.initials: MV
authors.lastname: Khutornaya
authors.affiliation: Research Institute for Cardiology, Tomsk, Russia.
authors.forename: A G
authors.initials: AG
authors.lastname: Kutikhin
mesh_terms: D000818:Animals; D001145:Arrhythmias, Cardiac / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D001794:Blood Pressure / Q000187:drug effects; D002118:Calcium / Q000378:metabolism; D054059:Coronary Occlusion; D003331:Coronary Vessels / Q000601:surgery; D013759:Dronabinol / Q000031:analogs & derivatives* / Q000494:pharmacology; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D057775:Ischemic Postconditioning; D008297:Male; D015428:Myocardial Reperfusion Injury / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D032383:Myocytes, Cardiac / Q000187:drug effects / Q000378:metabolism; D018696:Neuroprotective Agents / Q000494:pharmacology*; D009924:Organ Culture Techniques; D051381:Rats; D017208:Rats, Wistar; D043882:Receptors, Cannabinoid / Q000378:metabolism; D017725:Ventricular Pressure / Q000187:drug effects
chemical_list: D018691:Excitatory Amino Acid Antagonists; D018696:Neuroprotective Agents; D043882:Receptors, Cannabinoid; D013759:Dronabinol; C062018:HU 211; D002118:Calcium
keywords: heart; ischemia; postconditioning; reperfusion