title: Interventions for the Management of Denture Stomatitis: A Systematic Review and Meta-Analysis.
abstract: To assess the effectiveness of different interventions for treating or preventing denture stomatitis (DS).
  
  
  
  Systematic review.
  
  
  
  Randomized controlled trials (RCTs) comparing any agent or procedure prescribed to treat or prevent DS in adults.
  
  
  
  Older adults with denture stomatitis.
  
  
  
  There were two main outcomes reported in the trials included in this review: clinical signs of DS and remaining presence of yeast. There were no restrictions regarding language or date of publication. The search period was up to February 2016.
  
  
  
  Thirty-five studies were included in the systematic review, with 32 judged as having high risk of bias. Three RCTs compared nystatin with placebo and found a significant effect on the reduction of clinical signs of stomatitis (risk ratio (RR) = 0.51, 95% confidence interval (CI) = 0.36-0.72), four RCTs compared nystatin with placebo and found a significant effect on mycological assessment (RR = 0.61, 95% CI = 0.46-0.80). Five studies of disinfectant agents also showed a significant effect in comparison with an inactive agent (RR = 0.52, 95% CI = 0.30-0.92) in clinical assessment. No evidence was found of an effect of miconazole, amphotericin, or imidazolic drugs. No RCT evaluated the effectiveness of preventive approaches.
  
  
  
  The results are supportive of the use of nystatin and disinfecting agents in the treatment of DS, but clinicians need to be aware that individual studies had high risk of bias and that the overall quality of the individual reports was judged to be low.
authors.affiliation: Postgraduate Program in Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.|Postgraduate Program in Epidemiology, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
authors.forename: Juliana Balbinot
authors.initials: JB
authors.lastname: Hilgert
authors.affiliation: Postgraduate Program in Epidemiology, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
authors.forename: Jessye Melgarejo do Amaral
authors.initials: JM
authors.lastname: Giordani
authors.affiliation: Department of Dental Materials and Prosthetics, University of São Paulo, Ribeirão Preto, Brazil.|Division of Oral Health and Society, McGill University, Montreal, Québec, Canada.
authors.forename: Raphael Freitas
authors.initials: RF
authors.lastname: de Souza
authors.affiliation: Department of Public Health, Federal University of Health Sciences of Porto Alegre, Porto Alegre, Brazil.
authors.forename: Eliana Márcia Da Ros
authors.initials: EM
authors.lastname: Wendland
authors.affiliation: Postgraduate Program in Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
authors.forename: Otavio Pereira
authors.initials: OP
authors.lastname: D'Avila
authors.affiliation: Postgraduate Program in Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
authors.forename: Fernando Neves
authors.initials: FN
authors.lastname: Hugo
mesh_terms: D006801:Humans; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors; D013282:Stomatitis, Denture / Q000628:therapy*
keywords: denture stomatitis; meta-analysis; oral health; randomized controlled trial; systematic review; treatment