title: What Twin Studies Have Taught Us About Myopia.
abstract: Myopia has become epidemic, particularly in East Asia, and is a major cause of visual impairment worldwide. Twin studies are an important resource to investigate the genetics and the gene-environment interaction in myopia. This article aims to provide an overview of major findings regarding myopia from different types of twin studies, from the heritability of myopia-related traits to novel findings of genome-wide association studies. In the postgenomic era, twin studies will continue to serve as a unique method in the investigation of gene-environment interaction.
authors.affiliation: From the *State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, China; and †Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, Australia.
authors.forename: Yanxian
authors.initials: Y
authors.lastname: Chen
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Xiaotong
authors.initials: X
authors.lastname: Han
authors.forename: William
authors.initials: W
authors.lastname: Yan
authors.forename: Mingguang
authors.initials: M
authors.lastname: He
mesh_terms: D059647:Gene-Environment Interaction; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D009216:Myopia / Q000209:etiology* / Q000235:genetics; D018433:Twin Studies as Topic