title: Prevalence of papillomavirus in Brazil: a systematic review protocol.
abstract: Human papillomavirus (HPV) infection is a cause of premalignant and malignant cancer in the lower genital and digestive tracts. In Brazil, there have been no prevalence studies that included a nationwide sample, and the prevalence of HPV has not been determined in many regions.
  
  
  
  We will search the EMBASE, LILACS, MEDLINE, Web of Science and SciELO databases and previously published review articles to identify original research articles assessing HPV prevalence of the perineal (cervical, penile and anal) and oral areas. No exclusion criteria related to language or publication date will apply. 2 reviewers will independently screen for eligibility and perform data extraction. Discrepancies will be resolved through consensus; the opinion of a third reviewer will be sought as necessary. Relevant measures and data about study and population characteristics will be extracted from the included studies. Where possible, study prevalence will be pooled using a random-effects meta-analysis. The methodological quality of the studies will be assessed using an adapted version of the NIH 'Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies'. The overall quality of evidence will be assessed using Grading of Recommendations Assessment, Development and Evaluation (GRADE).
  
  
  
  We expect to estimate the prevalence of perineal and oral HPV infection in the general population as well as the prevalence of HPV infection in individuals with premalignant and malignant lesions in Brazil and its 5 geographic regions. This systematic review does not require ethical approval.
  
  
  
  CRD42016032751.
authors.affiliation: Hospital Moinhos de Vento, Porto Alegre, Brazil.
authors.forename: Verônica
authors.initials: V
authors.lastname: Colpani
authors.affiliation: Hospital Moinhos de Vento, Porto Alegre, Brazil.|Post-Graduate Program in Epidemiology, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
authors.forename: Augusto Bacelo
authors.initials: AB
authors.lastname: Bidinotto
authors.affiliation: Hospital Moinhos de Vento, Porto Alegre, Brazil.
authors.forename: Maicon
authors.initials: M
authors.lastname: Falavigna
authors.affiliation: Department of STDs/AIDS and Viral Hepatitis, Health Surveillance Secretariat, Ministry of Health, Brasilia, Brazil.
authors.forename: Silvana Pereira
authors.initials: SP
authors.lastname: Giozza
authors.affiliation: Department of STDs/AIDS and Viral Hepatitis, Health Surveillance Secretariat, Ministry of Health, Brasilia, Brazil.
authors.forename: Adele Schwartz
authors.initials: AS
authors.lastname: Benzaken
authors.affiliation: Department of STDs/AIDS and Viral Hepatitis, Health Surveillance Secretariat, Ministry of Health, Brasilia, Brazil.
authors.forename: Cristina
authors.initials: C
authors.lastname: Pimenta
authors.affiliation: National Program of Immunization/Health Surveillance Secretariat, Ministry of Health, Brasilia, Brazil.
authors.forename: Ana Goretti Kalume
authors.initials: AG
authors.lastname: Maranhão
authors.affiliation: National Program of Immunization/Health Surveillance Secretariat, Ministry of Health, Brasilia, Brazil.
authors.forename: Carla Magda Allan Santos
authors.initials: CM
authors.lastname: Domingues
authors.affiliation: Hospital Moinhos de Vento, Porto Alegre, Brazil.
authors.forename: Luciano Serpa
authors.initials: LS
authors.lastname: Hammes
authors.affiliation: Hospital Moinhos de Vento, Porto Alegre, Brazil.
authors.forename: Eliana M
authors.initials: EM
authors.lastname: Wendland
mesh_terms: D001938:Brazil / Q000453:epidemiology; D003430:Cross-Sectional Studies; D006801:Humans; D009055:Mouth / Q000821:virology; D027383:Papillomaviridae / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000453:epidemiology*; D010502:Perineum / Q000821:virology; D011230:Precancerous Conditions / Q000821:virology; D015995:Prevalence; D000078202:Systematic Reviews as Topic
keywords: Brazil; HPV; Human Papillomavirus; Prevalence