title: Transmissibility of the Influenza Virus during Influenza Outbreaks and Related Asymptomatic Infection in Mainland China, 2005-2013.
abstract: We collected 2768 Influenza-like illness emergency public health incidents from April 1, 2005 to November 30, 2013reported in the Emergency Public Reporting System. After screening by strict inclusion and exclusion criteria, there were 613 outbreaks analyzed with susceptible-exposed-infectious/asymptomatic-removed model in order to estimate the proportion of asymptomatic individuals (p) and the effective reproduction number (Rt). The relation between Rt and viral subtypes, regions, outbreak sites, populations, and seasons were analyzed. The mean values of p of different subtypes ranged from 0.09 to 0.15, but could be as high as up to 0.94. Different subtypes, provinces, regions, and sites of outbreak had statistically significantly different Rt. In particular, the southern region also manifested different Rt by affected population size and seasonality. Our results provide China and also the rest of the world a reference to understand characteristics of transmission and develop prevention and control strategies.
authors.affiliation: National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases, Chinese Center for Disease Control and Prevention; Key Laboratory for Medical Virology, National Health and Family Planning Commission, Beijing 102206, P.R. China.
authors.forename: Tao
authors.initials: T
authors.lastname: Chen
authors.affiliation: Department of Malaria, National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai, P.R. China.|Changsha Center for Disease Control and Prevention, Changsha, P.R. China.
authors.forename: Tianmu
authors.initials: T
authors.lastname: Chen
authors.affiliation: Changsha Center for Disease Control and Prevention, Changsha, P.R. China.
authors.forename: Ruchun
authors.initials: R
authors.lastname: Liu
authors.affiliation: National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases, Chinese Center for Disease Control and Prevention; Key Laboratory for Medical Virology, National Health and Family Planning Commission, Beijing 102206, P.R. China.
authors.forename: Cuiling
authors.initials: C
authors.lastname: Xu
authors.affiliation: National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases, Chinese Center for Disease Control and Prevention; Key Laboratory for Medical Virology, National Health and Family Planning Commission, Beijing 102206, P.R. China.
authors.forename: Dayan
authors.initials: D
authors.lastname: Wang
authors.affiliation: Changsha Center for Disease Control and Prevention, Changsha, P.R. China.
authors.forename: Faming
authors.initials: F
authors.lastname: Chen
authors.affiliation: National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases, Chinese Center for Disease Control and Prevention; Key Laboratory for Medical Virology, National Health and Family Planning Commission, Beijing 102206, P.R. China.
authors.forename: Wenfei
authors.initials: W
authors.lastname: Zhu
authors.affiliation: Changsha Center for Disease Control and Prevention, Changsha, P.R. China.
authors.forename: Xixing
authors.initials: X
authors.lastname: Zhang
authors.affiliation: National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases, Chinese Center for Disease Control and Prevention; Key Laboratory for Medical Virology, National Health and Family Planning Commission, Beijing 102206, P.R. China.
authors.forename: Jing
authors.initials: J
authors.lastname: Yang
authors.affiliation: National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases, Chinese Center for Disease Control and Prevention; Key Laboratory for Medical Virology, National Health and Family Planning Commission, Beijing 102206, P.R. China.
authors.forename: Lijie
authors.initials: L
authors.lastname: Wang
authors.affiliation: Changsha Center for Disease Control and Prevention, Changsha, P.R. China.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Xie
authors.affiliation: National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases, Chinese Center for Disease Control and Prevention; Key Laboratory for Medical Virology, National Health and Family Planning Commission, Beijing 102206, P.R. China.
authors.forename: Yongkun
authors.initials: Y
authors.lastname: Chen
authors.affiliation: National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases, Chinese Center for Disease Control and Prevention; Key Laboratory for Medical Virology, National Health and Family Planning Commission, Beijing 102206, P.R. China.
authors.forename: Tian
authors.initials: T
authors.lastname: Bai
authors.affiliation: Changsha Center for Disease Control and Prevention, Changsha, P.R. China.
authors.forename: Yelan
authors.initials: Y
authors.lastname: Li
authors.affiliation: Changsha Center for Disease Control and Prevention, Changsha, P.R. China.
authors.forename: Zhiyu
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Changsha Center for Disease Control and Prevention, Changsha, P.R. China.
authors.forename: Min
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Changsha Center for Disease Control and Prevention, Changsha, P.R. China.
authors.forename: Shuilian
authors.initials: S
authors.lastname: Chen
authors.affiliation: National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases, Chinese Center for Disease Control and Prevention; Key Laboratory for Medical Virology, National Health and Family Planning Commission, Beijing 102206, P.R. China.
authors.forename: Yuelong
authors.initials: Y
authors.lastname: Shu
mesh_terms: D002681:China / Q000453:epidemiology; D004196:Disease Outbreaks; D006801:Humans; D007251:Influenza, Human / Q000453:epidemiology / Q000635:transmission* / Q000821:virology; D008962:Models, Theoretical; D009975:Orthomyxoviridae / Q000145:classification / Q000302:isolation & purification; D011159:Population Surveillance; D012621:Seasons