title: Von Willebrand factor and coagulation factor VIII in Moyamoya disease associated with Graves' disease: A case report.
abstract: The present study reported the case of a Chinese boy who was diagnosed with Moyamoya disease (MMD) associated with Graves' disease (GD). An overactivation of von Willebrand factor (vWF) and coagulation factor VIII (FVIII) was identified in the plasma of the patient. Thiamazole and metoprolol treatment was thus administrated. After 2 months of treatment, the patient's thyroid function returned to normal and the neurological symptoms improved gradually. At the same time, the activities of vWF and FVIII were depressed. During the 20-month follow-up, information regarding the neurological symptoms, cerebrovascular imaging, thyroid function, thyroid autoantibodies and coagulation parameters was collected. High levels of thyroid autoantibodies persisted throughout the follow-up period, while other coagulation parameters remained in the normal range. In conclusion, considering the vital role of vWF and FVIII in vascular diseases, it is hypothesized that these two factors may serve an important role in the occurrence of GD associated with MMD.
authors.affiliation: Department of Pediatrics, Beijing Tian Tan Hospital, Capital Medical University, Beijing 100050, P.R. China.
authors.forename: Shou-Chen
authors.initials: SC
authors.lastname: Ren
authors.affiliation: Department of Pediatrics, Beijing Tian Tan Hospital, Capital Medical University, Beijing 100050, P.R. China.
authors.forename: Bao-Qin
authors.initials: BQ
authors.lastname: Gao
authors.affiliation: Department of Pediatrics, Beijing Tian Tan Hospital, Capital Medical University, Beijing 100050, P.R. China.
authors.forename: Wei-Li
authors.initials: WL
authors.lastname: Yang
authors.affiliation: Department of Pediatrics, Beijing Tian Tan Hospital, Capital Medical University, Beijing 100050, P.R. China.
authors.forename: Wei-Xin
authors.initials: WX
authors.lastname: Feng
authors.affiliation: Department of Endocrinology, Beijing Tian Tan Hospital, Capital Medical University, Beijing 100050, P.R. China.
authors.forename: Jian
authors.initials: J
authors.lastname: Xu
authors.affiliation: Department of Functional Neuroimaging, Beijing Neurosurgical Institute, Capital Medical University, Beijing 100050, P.R. China.
authors.forename: Shao-Wu
authors.initials: SW
authors.lastname: Li
authors.affiliation: Department of Neurology, Beijing Tian Tan Hospital, Capital Medical University, Beijing 100050, P.R. China.
authors.forename: Yong-Jun
authors.initials: YJ
authors.lastname: Wang
keywords: Graves' disease; Moyamoya disease; coagulation factor VIII; von Willebrand factor