title: Evaluation of Acute Kidney Injury Using Contrast Ultrasonography in a Rabbit Model of Crush Syndrome.
abstract: This study aimed to investigate the feasibility of evaluating acute kidney injury (AKI) using contrast ultrasonography in a rabbit model of crush syndrome. Sixty-four New Zealand white rabbits were anesthetized and the left hind limb was wrapped and compressed for 4 h with a sphygmomanometer. Contrast ultrasonography of the left kidney using microbubbles as the contrast medium was performed. The serum levels of blood urea nitrogen (BUN), creatine (Cr), creatine kinase (CK) and lactate dehydrogenase (LDH) were significantly increased in comparison to before the compression. Correlation analysis showed that peak intensity was negatively correlated with the biochemical parameters and area under the curve (AUC) was positively correlated with these parameters. Contrast ultrasonography is thus sensitive to the changes in renal perfusion after limb crush injury in rabbits. The ultrasonography results correlated well with the biochemical parameters that are related to muscle injury and AKI.
authors.affiliation: Department of Ultrasound, PLA Bethune International Peace Hospital, Shijiazhuang, China. Electronic address: ultrasoundzc@163.com.
authors.forename: Chundong
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Department of Pediatrics, PLA Bethune International Peace Hospital, Shijiazhuang, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Ultrasound, Chinese PLA General Hospital, Beijing, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Tang
mesh_terms: D058186:Acute Kidney Injury / Q000000981:diagnostic imaging* / Q000209:etiology* / Q000503:physiopathology; D000818:Animals; D003287:Contrast Media; D003444:Crush Syndrome / Q000150:complications* / Q000503:physiopathology; D004195:Disease Models, Animal; D005240:Feasibility Studies; D007089:Image Enhancement / Q000379:methods*; D007668:Kidney / Q000000981:diagnostic imaging; D010743:Phospholipids; D011817:Rabbits; D013459:Sulfur Hexafluoride
chemical_list: D003287:Contrast Media; D010743:Phospholipids; C420843:contrast agent BR1; D013459:Sulfur Hexafluoride
keywords: Acute kidney injury; Area under the curve; Crush syndrome; Rabbits