title: Hepatic Histological Changes in Ulcerative Colitis.
abstract: Operative liver biopsy was performed on 58 consecutive patients coming to radical excisional surgery for ulcerative colitis. The histological changes seen in the liver were: increased cellularity of the portal tracts (83 per cent); fatty infiltration (83 per cent); areas of focal necrosis (47 per cent); and early cirrhosis (2 per cent). Severe liver damage was shown to he associated with severe active colitis, and with a poor subsequent post-operative prognosis. The mechanisms responsible for liver damage in patients with colitis are discussed.
authors.affiliation: a University Department of Surgery , The General Infirmary, Leeds, and Department of Pathology, St. James Hospital , Leeds , England.
authors.forename: F T
authors.initials: FT
authors.lastname: de Dombal
authors.affiliation: a University Department of Surgery , The General Infirmary, Leeds, and Department of Pathology, St. James Hospital , Leeds , England.
authors.forename: W
authors.initials: W
authors.lastname: Goldie
authors.affiliation: a University Department of Surgery , The General Infirmary, Leeds, and Department of Pathology, St. James Hospital , Leeds , England.
authors.forename: J McK
authors.initials: JM
authors.lastname: Watts
authors.affiliation: a University Department of Surgery , The General Infirmary, Leeds, and Department of Pathology, St. James Hospital , Leeds , England.|b University Department of Surgery The General Infirmary Leeds , England.
authors.forename: J C
authors.initials: JC
authors.lastname: Goligher
keywords: Liver; biopsy; colitis, ulcerative; histology