title: Patients on psychotropic medications and herbal supplement combinations: clinical considerations.
abstract: Populations using herbs and herbal preparations are widespread and growing. As many herbal ingredients exert actions on psychotropic drug targets, psychiatrists should be well informed and aware of potential drug-drug interactions in clinical practice. Reliable and clinically useful information in this area, however, is fragmented, if not deficient. This paper reviewed the clinical aspects of herb-drug interactions, focusing in particular on the monoamine oxidase enzyme and P450 cytochrome enzyme-inhibitory properties of herbs and their potential interference with psychotropic drug actions and clinical judgement.
authors.affiliation: aDepartment of Psychiatry, School of Medicine, University of California, Irvine, California, USA bInstitute of Brain Medicine, Central, Hong Kong Special Administrative Region cDepartment of Pharmacology, National University of Ireland, Galway, Ireland.
authors.forename: Siu Wa
authors.initials: SW
authors.lastname: Tang
authors.forename: Wayne
authors.initials: W
authors.lastname: Tang
authors.forename: Brian E
authors.initials: BE
authors.lastname: Leonard
mesh_terms: D041743:Herb-Drug Interactions / Q000502:physiology*; D006801:Humans; D001523:Mental Disorders / Q000188:drug therapy* / Q000378:metabolism; D008996:Monoamine Oxidase Inhibitors / Q000009:adverse effects / Q000378:metabolism / Q000627:therapeutic use; D008517:Phytotherapy / Q000009:adverse effects / Q000379:methods*; D028321:Plant Preparations / Q000009:adverse effects / Q000378:metabolism / Q000627:therapeutic use*; D011619:Psychotropic Drugs / Q000009:adverse effects / Q000378:metabolism / Q000627:therapeutic use*
chemical_list: D008996:Monoamine Oxidase Inhibitors; D028321:Plant Preparations; D011619:Psychotropic Drugs