title: Eradication ofHelicobacter pyloriInfection Restores ki67, p53, and Cyclin D1 Immunoreactivity in the Human Gastric Epithelium.
abstract: BACKGROUND
  We evaluated the effect ofHelicobacter pylori(HP) eradication on p53, cyclin D1 expression, and cell proliferation in gastric mucosa.
  
  
  METHODS
  We assessed p53, cyclin D1, and ki67 immunoexpression in gastric mucosa from 31 HP chronic gastritis patients and 12 controls. Reassessment was performed 6 months after successful HP eradication.
  
  
  RESULTS
  Successful eradication resulted in significant decrease of p53 (1.53 ± 0.16 vs 0.83 ± 0.19,P= 0.01) and ki67 (9.84 ± 0.96 vs 4.77 ± 0.27,P< 0.001) staining in the antrum. Similarly, p53 immunoreactivity significantly decreased in the corpus (1.27 ± 0.20 vs 0.46 ± 0.15,P= 0.02), while there was a trend for decreased corpus cyclin D1 and ki67 expression (0.17 ± 0.07 vs 0.0,P= 0.08 and 8.71 ± 1.24 vs 5.85 ± 0.54,P= 0.09, respectively). Importantly, after successful HP eradication, the immunoreactivity of the studied parameters was similar to that of controls.
  
  
  CONCLUSIONS
  Successful HP infection eradication restores p53, cyclin D1, and ki67 immunoreactivity in the gastric mucosa to the level of controls.
authors.affiliation: Hepatogastroenterology Unit, Second Department of Internal Medicine-Propaedeutic, Research Institute and Diabetes Center, Medical School, National and Kapodistrian University of Athens, Attikon University General Hospital, Athens, Greece.
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Triantafyllou
authors.affiliation: Hepatogastroenterology Unit, Second Department of Internal Medicine-Propaedeutic, Research Institute and Diabetes Center, Medical School, National and Kapodistrian University of Athens, Attikon University General Hospital, Athens, Greece.
authors.forename: Vasilios
authors.initials: V
authors.lastname: Papadopoulos
authors.affiliation: Hepatogastroenterology Unit, Second Department of Internal Medicine-Propaedeutic, Research Institute and Diabetes Center, Medical School, National and Kapodistrian University of Athens, Attikon University General Hospital, Athens, Greece.
authors.forename: Theodoros
authors.initials: T
authors.lastname: Emanouil
authors.affiliation: Hepatogastroenterology Unit, Second Department of Internal Medicine-Propaedeutic, Research Institute and Diabetes Center, Medical School, National and Kapodistrian University of Athens, Attikon University General Hospital, Athens, Greece.
authors.forename: Paraskevas
authors.initials: P
authors.lastname: Gkolfakis
authors.affiliation: Second Department of Pathology Medical School, National and Kapodistrian University of Athens, Attikon University General Hospital, Athens, Greece.
authors.forename: Vasileia
authors.initials: V
authors.lastname: Damaskou
authors.affiliation: Hepatogastroenterology Unit, Second Department of Internal Medicine-Propaedeutic, Research Institute and Diabetes Center, Medical School, National and Kapodistrian University of Athens, Attikon University General Hospital, Athens, Greece.
authors.forename: Georgios
authors.initials: G
authors.lastname: Tziatzios
authors.affiliation: Second Department of Pathology Medical School, National and Kapodistrian University of Athens, Attikon University General Hospital, Athens, Greece.
authors.forename: Ioannis G
authors.initials: IG
authors.lastname: Panayiotides
authors.affiliation: Academic Department of Gastroenterology, Medical School, National and Kapodistrian University of Athens, Laiko General Hospital, Athens, Greece.
authors.forename: Irene
authors.initials: I
authors.lastname: Vafiadis
authors.affiliation: Academic Department of Gastroenterology, Medical School, National and Kapodistrian University of Athens, Laiko General Hospital, Athens, Greece.
authors.forename: Spiros D
authors.initials: SD
authors.lastname: Ladas
keywords: Helicobacter pylori; cyclin D1; eradication; ki67; p53