title: Body height as risk factor for emphysema in COPD.
abstract: Pulmonary emphysema is a phenotypic component of chronic obstructive pulmonary disease (COPD) which carries substantial morbidity and mortality. We explored the association between emphysema and body height in 726 patients with COPD using computed tomography as the reference diagnostic standard for emphysema. We applied univariate analysis to look for differences between patients with emphysema and those without, and multivariate logistic regression to identify significant predictors of the risk of emphysema. As covariates we included age, sex, body height, body mass index, pack-years of smoking, and forced expiratory volume in one second (FEV1) as percent predicted. The overall prevalence of emphysema was 52%. Emphysemic patients were significantly taller and thinner than non-emphysemic ones, and featured significantly higher pack-years of smoking and lower FEV1(P < 0.001). The prevalence of emphysema rose linearly by 10-cm increase in body height (r2= 0.96). In multivariate analysis, the odds of emphysema increased by 5% (95% confidence interval, 3 to 7%) along with one-centimeter increase in body height, and remained unchanged after adjusting for all the potential confounders considered (P < 0.001). The odds of emphysema were not statistically different between males and females. In conclusion, body height is a strong, independent risk factor for emphysema in COPD.
authors.affiliation: Department of Experimental and Clinical Medicine, University of Florence, 50134 Florence, Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Miniati
authors.affiliation: Unit of Biostatistics, Department of Environmental Medicine, Karolinska Institutet, 17177 Stockholm, Sweden.
authors.forename: Matteo
authors.initials: M
authors.lastname: Bottai
authors.affiliation: Institute of Clinical Physiology, National Research Council of Italy, 56124 Pisa, Italy.
authors.forename: Ivana
authors.initials: I
authors.lastname: Pavlickova
authors.affiliation: Institute of Clinical Physiology, National Research Council of Italy, 56124 Pisa, Italy.|"Gabriele Monasterio" Tuscany Foundation, 56124 Pisa, Italy.
authors.forename: Simonetta
authors.initials: S
authors.lastname: Monti
mesh_terms: D000367:Age Factors; D000368:Aged; D001827:Body Height; D015992:Body Mass Index; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D016015:Logistic Models; D008168:Lung / Q000000981:diagnostic imaging / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology*; D011656:Pulmonary Emphysema / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000209:etiology; D012307:Risk Factors; D012720:Severity of Illness Index; D012737:Sex Factors; D012907:Smoking; D014057:Tomography, X-Ray Computed