title: Endometriosis research using capture microdissection techniques: Progress and future applications.
abstract: Endometriosis is a common gynecological disease with high prevalence, while its etiology and pathophysiology have remained to be fully elucidated. Previous evidence suggested that this disorder may be in part or completely of somatic origin. However, traditional endometrial samples may not be ideal for investigation, as target cells, including epithelial and stromal cells, in endometriotic lesions are too sparse to be analyzed. Recently, capture microdissection techniques have been used to overcome these limitations and eliminate tissue heterogeneity in endometriosis research. Therefore, the present review summarized the alterations in epithelial and stromal cells in endometriosis tissues isolated through capture microdissection, outlined recent progress and provided directions for future investigation of the pathogenesis of endometriosis.
authors.affiliation: Department of Gynecology and Obstetrics, Chinese People's Liberation Army (PLA) Medical School, Chinese PLA General Hospital, Beijing 100853, P.R. China.
authors.forename: Luyang
authors.initials: L
authors.lastname: Zhao
authors.affiliation: Department of Gynecology and Obstetrics, Chinese People's Liberation Army (PLA) Medical School, Chinese PLA General Hospital, Beijing 100853, P.R. China; Department of Gynecology and Obstetrics, the 309th Hospital of the PLA, Beijing 100091, P.R. China.
authors.forename: Chenglei
authors.initials: C
authors.lastname: Gu
authors.affiliation: Department of Gynecology and Obstetrics, Chinese People's Liberation Army (PLA) Medical School, Chinese PLA General Hospital, Beijing 100853, P.R. China.
authors.forename: Ke
authors.initials: K
authors.lastname: Huang
authors.affiliation: Department of Molecular Biology, Institute of Basic Medicine, PLA Medical School, Chinese PLA General Hospital, Beijing 100853, P.R. China.
authors.forename: Weidong
authors.initials: W
authors.lastname: Han
authors.affiliation: Department of Gynecology and Obstetrics, Chinese People's Liberation Army (PLA) Medical School, Chinese PLA General Hospital, Beijing 100853, P.R. China; Department of Gynecology and Obstetrics, Haidian Maternal and Child Health Hospital, Beijing 100080, P.R. China.
authors.forename: Meng
authors.initials: M
authors.lastname: Fu
authors.affiliation: Department of Gynecology and Obstetrics, Chinese People's Liberation Army (PLA) Medical School, Chinese PLA General Hospital, Beijing 100853, P.R. China.
authors.forename: Yuanguang
authors.initials: Y
authors.lastname: Meng
keywords: clonality analysis; endometriosis; loss of heterozygosity; microdissection; somatic copy number alteration