title: Hepatitis C Virus Infection and Rheumatic Diseases: The Impact of Direct-Acting Antiviral Agents.
abstract: Chronic hepatitis C virus (HCV) infection is associated with liver and extrahepatic complications, including B-cell lymphoma, cardiovascular and kidney diseases, glucose metabolism impairment and rheumatic conditions ie, arthralgia, myalgia, cryoglobulinemia vasculitis, sicca syndrome and the production of autoantibodies. The treatment has long been based on interferon alpha (IFN) that was found poorly effective, and contraindicated in many autoimmune/inflammatory disorders because of possible exacerbation of rheumatic disorders. The recent emergence of new oral IFN-free combinations offers an opportunity for HCV infected patients with autoimmune/inflammatory disorders to be cured with a short treatment duration and low risk of side effects.
authors.affiliation: Inflammation-Immunopathology-Biotherapy Department (DHU i2B), Sorbonne Universités, UPMC Université Paris 06, UMR 7211, Paris F-75005, France; INSERM, UMR_S 959, Paris F-75013, France; CNRS, FRE3632, Paris F-75005, France; Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology, Hôpital Pitié-Salpêtrière, AP-HP, 83 boulevard de l'hôpital, Paris F-75013, France. Electronic address: patrice.cacoub@aphp.fr.
authors.forename: Patrice
authors.initials: P
authors.lastname: Cacoub
authors.affiliation: Inflammation-Immunopathology-Biotherapy Department (DHU i2B), Sorbonne Universités, UPMC Université Paris 06, UMR 7211, Paris F-75005, France; INSERM, UMR_S 959, Paris F-75013, France; CNRS, FRE3632, Paris F-75005, France; Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology, Hôpital Pitié-Salpêtrière, AP-HP, 83 boulevard de l'hôpital, Paris F-75013, France.
authors.forename: Cloé
authors.initials: C
authors.lastname: Commarmond
authors.affiliation: Inflammation-Immunopathology-Biotherapy Department (DHU i2B), Sorbonne Universités, UPMC Université Paris 06, UMR 7211, Paris F-75005, France; INSERM, UMR_S 959, Paris F-75013, France; CNRS, FRE3632, Paris F-75005, France; Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology, Hôpital Pitié-Salpêtrière, AP-HP, 83 boulevard de l'hôpital, Paris F-75013, France.
authors.forename: David
authors.initials: D
authors.lastname: Sadoun
authors.affiliation: Inflammation-Immunopathology-Biotherapy Department (DHU i2B), Sorbonne Universités, UPMC Université Paris 06, UMR 7211, Paris F-75005, France; INSERM, UMR_S 959, Paris F-75013, France; CNRS, FRE3632, Paris F-75005, France; Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology, Hôpital Pitié-Salpêtrière, AP-HP, 83 boulevard de l'hôpital, Paris F-75013, France.
authors.forename: Anne Claire
authors.initials: AC
authors.lastname: Desbois
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use*; D018771:Arthralgia / Q000209:etiology; D001323:Autoantibodies / Q000276:immunology; D000075202:Contraindications; D003449:Cryoglobulinemia; D019698:Hepatitis C, Chronic / Q000150:complications / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D016898:Interferon-alpha; D063806:Myalgia / Q000209:etiology; D012216:Rheumatic Diseases / Q000150:complications; D012859:Sjogren's Syndrome / Q000209:etiology; D014657:Vasculitis / Q000209:etiology
chemical_list: D000998:Antiviral Agents; D001323:Autoantibodies; D016898:Interferon-alpha
keywords: Arthralgia; Arthritis; Direct-acting antiviral agents (DAA); Hepatitis C (HCV); Rheumatic disorders; Sicca syndrome; Treatment; Vasculitis