title: An Ir(III) complex chemosensor for the detection of thiols.
abstract: In this study, we report the use of a cyclometalated luminescent iridium(III) complex for the visualization of thiols. The detection of glutathione (GSH) by complex1is achieved through the reduction of its phendione N^N donor, which influences the metal-to-ligand charge-transfer (MLCT) of the complex. Complex1produced a maximum threefold luminescence enhancement at 587 nm in response to GSH. The linear detection range of1for GSH is between 0.2 and 2 M equivalents of GSH, with a detection limit of 1.67 μM. Complex1also displays good selectivity for thiols over other amino acids.
authors.affiliation: Department of Chemistry, Hong Kong Baptist University , Kowloon Tong, Hong Kong , P.R. China.
authors.forename: Zhifeng
authors.initials: Z
authors.lastname: Mao
authors.affiliation: Department of Chemistry, Hong Kong Baptist University , Kowloon Tong, Hong Kong , P.R. China.
authors.forename: Jinbiao
authors.initials: J
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau , Macao , P.R. China.
authors.forename: Tian-Shu
authors.initials: TS
authors.lastname: Kang
authors.affiliation: Department of Chemistry, Hong Kong Baptist University , Kowloon Tong, Hong Kong , P.R. China.
authors.forename: Wanhe
authors.initials: W
authors.lastname: Wang
authors.affiliation: School of Chinese Medicine, Hong Kong Baptist University , Kowloon Tong , Hong Kong , P.R. China.
authors.forename: Quan-Bin
authors.initials: QB
authors.lastname: Han
authors.affiliation: State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau , Macao , P.R. China.
authors.forename: Chun-Ming
authors.initials: CM
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau , Macao , P.R. China.
authors.forename: Chung-Hang
authors.initials: CH
authors.lastname: Leung
authors.affiliation: Department of Chemistry, Hong Kong Baptist University , Kowloon Tong, Hong Kong , P.R. China.
authors.forename: Dik-Lung
authors.initials: DL
authors.lastname: Ma
keywords: 208 sensors and actuators; 30 Bio-inspired and biomedical materials; Iridium(III) complex; chemosensor; thiols