title: Genetic parameters for both a liver damage phenotype caused by and antibody response to phenotype in dairy and beef cattle.
abstract: is a helminth parasite of economic importance to the global cattle industry, with documented high international herd prevalence. The objective of the present study was to generate the first published genetic parameter estimates for liver damage caused by as well as antibody response to in cattle. Abattoir data on the presence of live , or -damaged livers, were available between the years 2012 and 2015, inclusive. A second data set was available on cows from 68 selected dairy herds with a blood ELISA test for antibody response to in autumn 2015. Animals were identified as exposed by using herd mate phenotype, and only exposed animals were retained for analysis. The abattoir data set consisted of 20,481 dairy cows and 75,041 young dairy and beef animals, whereas the study herd data set consisted of 6,912 dairy cows. (Co)variance components for phenotypes in both data sets were estimated using animal linear mixed models. Fixed effects included in the model for both data sets were contemporary group, heterosis coefficient, recombination loss coefficient, parity, age relative to parity/age group, and stage of lactation. An additional fixed effect of abattoir by date of slaughter was included in the model for the analysis of the abattoir data. Direct additive genetic effects and a residual effect were included as random effects for all analyses. After data edits, the prevalence of liver damage caused by in cows and young cattle was 47% and 20%, respectively. The prevalence of a positive antibody response to in cows from the study herd data was 36% after data edits. The heritability of as a binary trait for dairy cows in abattoir data and study herd data was 0.03 ± 0.01 and 0.09 ± 0.02, respectively; heritability in young cattle was 0.01 ± 0.005. The additive genetic SD of as a binary trait was 0.069 and 0.050 for cows and young cattle from the abattoir data, respectively, and 0.112 from the study herd cows. The genetic correlation between liver damage caused by in young cattle and cows from the abattoir data was 0.94 ± 0.312 and the genetic correlation between liver damage caused by in cows and positive antibody response to in cows in the study herd data was 0.37 ± 0.283.
authors.forename: A J
authors.initials: AJ
authors.lastname: Twomey
authors.forename: R G
authors.initials: RG
authors.lastname: Sayers
authors.forename: R I
authors.initials: RI
authors.lastname: Carroll
authors.forename: N
authors.initials: N
authors.lastname: Byrne
authors.forename: E O'
authors.initials: EO
authors.lastname: Brien
authors.forename: M L
authors.initials: ML
authors.lastname: Doherty
authors.forename: J C
authors.initials: JC
authors.lastname: McClure
authors.forename: D A
authors.initials: DA
authors.lastname: Graham
authors.forename: D P
authors.initials: DP
authors.lastname: Berry
mesh_terms: D000003:Abattoirs; D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000191:economics / Q000235:genetics* / Q000469:parasitology*; D005210:Fasciola hepatica / Q000502:physiology*; D005211:Fascioliasis / Q000191:economics / Q000235:genetics / Q000469:parasitology / Q000662:veterinary*; D005260:Female; D007774:Lactation; D016014:Linear Models; D008099:Liver / Q000473:pathology; D008297:Male; D011247:Pregnancy; D000069466:Red Meat