title: Frailty in Postmenopausal African American and Hispanic HIV-Infected Women.
abstract: Studies suggest frailty occurs earlier in HIV-infected individuals, but data in postmenopausal HIV-infected women are lacking. We assessed the prevalence of frailty and association with anthropometric measures in HIV-infected and uninfected postmenopausal women. Fried's frailty phenotype was measured in HIV-infected and uninfected Hispanic and African American postmenopausal women participating in a study of bone metabolism; fat and lean mass were measured by whole body dual energy x-ray absorptiometry (DXA). Multivariable logistic regression evaluated frailty risk factors. The study was conducted at Columbia University Medical Center between 2002 and 2007. The participants were 61 HIV-infected and 27 uninfected Hispanic and African American postmenopausal women. The study compared prevalence and predictors of frailty in HIV-infected and uninfected postmenopausal women. Prevalence of frailty tended to be higher among HIV-infected than uninfected controls (11.5% vs 0% p=0.07). Surprisingly, among HIV-infected women, total body fat, not lean mass, was associated with frailty in multivariate analysis. Higher prevalence of frailty in African American and Hispanic HIV-infected postmenopausal women (11.5%) was similar to the 11% prevalence reported in minority women who were 10 years older in the general population. Our data suggest that frailty occurs earlier in HIV-infected postmenopausal women, but larger longitudinal studies are necessary to confirm whether musculoskeletal aging is accelerated by HIV infection.
authors.affiliation: Michael T. Yin, MD, MS, 630 W 168th St, PH8-876, Box 82, New York, NY 10032, Mty4@columbia.edu, (212) 342-0062, Fax: (212) 305-7290.
authors.forename: P
authors.initials: P
authors.lastname: Young
authors.forename: J
authors.initials: J
authors.lastname: Shah
authors.forename: C
authors.initials: C
authors.lastname: Zhang
authors.forename: D C
authors.initials: DC
authors.lastname: Ferris
authors.forename: I
authors.initials: I
authors.lastname: Colon
authors.forename: M
authors.initials: M
authors.lastname: Bucovsky
authors.forename: M
authors.initials: M
authors.lastname: Punyanitya
authors.forename: D J
authors.initials: DJ
authors.lastname: McMahon
authors.forename: E
authors.initials: E
authors.lastname: Shane
authors.forename: M T
authors.initials: MT
authors.lastname: Yin
mesh_terms: D015502:Absorptiometry, Photon; D000273:Adipose Tissue; D001741:Black or African American / Q000706:statistics & numerical data*; D000368:Aged; D001823:Body Composition; D016022:Case-Control Studies; D005260:Female; D016330:Frail Elderly / Q000706:statistics & numerical data*; D015658:HIV Infections / Q000453:epidemiology*; D018737:Hand Strength; D006630:Hispanic or Latino / Q000706:statistics & numerical data*; D006801:Humans; D016015:Logistic Models; D008875:Middle Aged; D015999:Multivariate Analysis; D018482:Muscle, Skeletal; D017698:Postmenopause; D015995:Prevalence; D011446:Prospective Studies; D012307:Risk Factors; D014481:United States / Q000453:epidemiology