title: Does anticoagulation therapy prevent thrombosis in coronary stent grafts?
abstract: A polytetrafluoroethylene (PTFE)-covered stent was deployed for enlarging coronary aneurysms in a 73-year-old man. Optical coherence tomography (OCT) and coronary angioscopy performed 3 months later revealed naked stent struts and thin patches of red thrombi covering the PTFE membrane even under dual antiplatelet therapy (DAPT). After 5-month warfarin administration under DAPT, OCT and angioscopy showed a clear extinction of the thin patches of red thrombi on the PTFE membrane and stent struts, although most of the struts were still naked. The addition of anticoagulation therapy to DAPT may reduce thrombosis events in patients treated with PTFE-covered stents.
authors.affiliation: Division of Cardiology, Fuji Hospital, Shizuoka, Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Honda
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Showa University Koto-Toyosu Hospital, 5-1-38 Toyosu, Koto-ku, Tokyo, 135-8577, Japan. kwaka@live.jp.
authors.forename: Kohei
authors.initials: K
authors.lastname: Wakabayashi
authors.affiliation: Division of Cardiovascular Surgery, Fuji Hospital, Shizuoka, Japan.
authors.forename: Takayasu
authors.initials: T
authors.lastname: Suzuki
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Showa University Fujigaoka Hospital, Yokohama, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Suzuki
mesh_terms: D000368:Aged; D017546:Angioscopy; D000925:Anticoagulants / Q000627:therapeutic use*; D001672:Biocompatible Materials; D019917:Blood Vessel Prosthesis Implantation / Q000009:adverse effects*; D003323:Coronary Aneurysm / Q000000981:diagnostic imaging / Q000601:surgery*; D017023:Coronary Angiography; D003331:Coronary Vessels / Q000000981:diagnostic imaging; D004359:Drug Therapy, Combination; D006801:Humans; D008297:Male; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D011138:Polytetrafluoroethylene; D015607:Stents / Q000009:adverse effects*; D013927:Thrombosis / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control*; D041623:Tomography, Optical Coherence; D014859:Warfarin / Q000627:therapeutic use
chemical_list: D000925:Anticoagulants; D001672:Biocompatible Materials; D010975:Platelet Aggregation Inhibitors; D014859:Warfarin; D011138:Polytetrafluoroethylene
keywords: Angioscopy; Anticoagulation therapy; Polytetrafluoroethylene (PTFE)-covered stent; Stent thrombosis