title: Effects of cytomegalovirus infection on the prognosis of inflammatory bowel disease patients.
abstract: The aim of the present study was to investigate the effects of cytomegalovirus (CMV) infection on the prognosis of inflammatory bowel disease (IBD). Various databases were searched using a combination of keywords associated with CMV infection and IBD. Subsequent to the selection of relevant studies in line with strict inclusion and exclusion criteria, a meta-analysis was conducted using the Stata 12.0 software. A total of 195 studies were initially retrieved, including 28 studies in Chinese and 167 in English. Following the exclusion of unsuitable studies, 7 cohort studies with 374 IBD patients were included in the meta-analysis. The results of the present study identified significant differences between patients with and without CMV infection regarding the disease duration of IBD [standardized mean difference, -0.81; 95% confidence interval (CI), -1.19 to -0.43; P<0.001], the efficacy of corticosteroid therapy [relative risk (RR), 1.24; 95% CI, 1.02-1.49; P=0.029], the colectomy rate (RR, 2.13; 95% CI, 1.03-4.40; P=0.042) and the incidence of severe IBD (RR, 1.32; 95% CI, 1.04-1.67; P=0.022). Considering the IBD onset area, patients with CMV infection may have higher susceptibility to pancolitis (RR, 1.31; 95% CI; 1.01-1.72; P=0.045); however, no difference in susceptibility to left-sided IBD was observed between patients with or without CMV infection (RR, 0.97; 95% CI, 0.72-1.30; P=0.828). In conclusion, CMV infection may be associated with the disease duration, efficacy of corticosteroid therapy, colectomy rate, severe IBD incidence and disease location of IBD; thus, the presence of CMV infection may be considered as an important biomarker for determining the prognosis of IBD.
authors.affiliation: Department of Critical Care Medicine, Linyi People's Hospital, Linyi, Shandong 276003, P.R. China.
authors.forename: Wei-Xia
authors.initials: WX
authors.lastname: Zhang
authors.affiliation: Department of Critical Care Medicine, Linyi People's Hospital, Linyi, Shandong 276003, P.R. China.
authors.forename: Cheng-Yan
authors.initials: CY
authors.lastname: Ma
authors.affiliation: Department of Critical Care Medicine, Linyi People's Hospital, Linyi, Shandong 276003, P.R. China.
authors.forename: Jian-Guo
authors.initials: JG
authors.lastname: Zhang
authors.affiliation: Department of Critical Care Medicine, Linyi People's Hospital, Linyi, Shandong 276003, P.R. China.
authors.forename: Feng
authors.initials: F
authors.lastname: He
authors.affiliation: Department of Critical Care Medicine, Linyi People's Hospital, Linyi, Shandong 276003, P.R. China.
authors.forename: Qing-Min
authors.initials: QM
authors.lastname: Liu
authors.affiliation: Department of Critical Care Medicine, Linyi People's Hospital, Linyi, Shandong 276003, P.R. China.
authors.forename: Aibin
authors.initials: A
authors.lastname: Cheng
authors.affiliation: Department of Critical Care Medicine, Linyi People's Hospital, Linyi, Shandong 276003, P.R. China.
authors.forename: Tiejun
authors.initials: T
authors.lastname: Liu
authors.affiliation: Department of Critical Care Medicine, Linyi People's Hospital, Linyi, Shandong 276003, P.R. China.
authors.forename: Junwei
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Critical Care Medicine, Linyi People's Hospital, Linyi, Shandong 276003, P.R. China.
authors.forename: Jianjun
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Critical Care Medicine, Linyi People's Hospital, Linyi, Shandong 276003, P.R. China.
authors.forename: Xuan
authors.initials: X
authors.lastname: Bu
authors.affiliation: Department of Critical Care Medicine, Linyi People's Hospital, Linyi, Shandong 276003, P.R. China.
authors.forename: Yuxi
authors.initials: Y
authors.lastname: Xie
authors.affiliation: Department of Critical Care Medicine, Linyi People's Hospital, Linyi, Shandong 276003, P.R. China.
authors.forename: Zengli
authors.initials: Z
authors.lastname: Diao
authors.affiliation: Department of Critical Care Medicine, Linyi People's Hospital, Linyi, Shandong 276003, P.R. China.
authors.forename: Jing
authors.initials: J
authors.lastname: Bai
keywords: cytomegalovirus infection; inflammatory bowel disease; meta-analysis; prognosis