title: Effect of Resveratrol on periodontal pathogens during experimental periodontitis in rats.
abstract: The objective of this study was to investigate the antibacterial effect of resveratrol against putative periodontal pathogens during the progression of experimental periodontitis in rats. Periodontitis was induced in rats in one of the first molars chosen to receive a ligature. Animals were assigned to one of two groups: daily administration of the placebo solution (control group, n = 12) or 10 mg/Kg of resveratrol (RESV group, n = 12). The therapies were administered systemically for 30 days, for 19 days before periodontitis induction and then for another 11 days. Then, the presence and concentrations of Porphyromonas gingivalis, Tannerella forsythia and Aggregatibacter actinomycetemcomitans in the cotton ligatures collected from the first molars were evaluated using real-time PCR. Inter-group comparisons of the microbiological outcomes revealed that no differences were detected for P. gingivalis, T. forsythia and A. actinomycetemcomitans levels (p > 0.05). Continuous use of resveratrol did not promote additional benefits in microbiological outcomes during experimental periodontitis in rats.
authors.affiliation: Universidade Paulista, School of Dentistry, Dental Research Division, São Paulo, SP, Brazil.
authors.forename: Fabiano Ribeiro
authors.initials: FR
authors.lastname: Cirano
authors.affiliation: Universidade Paulista, School of Dentistry, Dental Research Division, São Paulo, SP, Brazil.
authors.forename: Renato Correa Viana
authors.initials: RC
authors.lastname: Casarin
authors.affiliation: Universidade Paulista, School of Dentistry, Dental Research Division, São Paulo, SP, Brazil.
authors.forename: Fernanda Vieira
authors.initials: FV
authors.lastname: Ribeiro
authors.affiliation: Universidade Paulista, School of Dentistry, Dental Research Division, São Paulo, SP, Brazil.
authors.forename: Marcio Zaffalon
authors.initials: MZ
authors.lastname: Casati
authors.affiliation: Universidade Paulista, School of Dentistry, Dental Research Division, São Paulo, SP, Brazil.
authors.forename: Suzana Peres
authors.initials: SP
authors.lastname: Pimentel
authors.affiliation: Universidade Estadual de Campinas - UNICAMP, School of Dentistry at Piracicaba, Department of Prosthodontics and Periodontics, Piracicaba, SP, Brazil.
authors.forename: Tiago
authors.initials: T
authors.lastname: Taiete
authors.affiliation: Universidade Paulista, School of Dentistry, Dental Research Division, São Paulo, SP, Brazil.
authors.forename: Maria Martha
authors.initials: MM
authors.lastname: Bernardi
mesh_terms: D016976:Aggregatibacter actinomycetemcomitans; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D004195:Disease Models, Animal; D008297:Male; D010518:Periodontitis / Q000188:drug therapy* / Q000382:microbiology*; D010519:Periodontium / Q000382:microbiology; D016966:Porphyromonas gingivalis / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D060888:Real-Time Polymerase Chain Reaction; D015203:Reproducibility of Results; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology* / Q000627:therapeutic use; D000070436:Tannerella forsythia / Q000187:drug effects; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D013267:Stilbenes; D000077185:Resveratrol