title: Four Years Prospective Study of Natural History of Atopic Dermatitis Aged 7~8 Years at an Individual Level: A Community-Based Survey by Dermatologists' Skin Examination in Childhood.
abstract: BACKGROUND
  The age-dependent change in atopic dermatitis (AD) at an individual level has mostly performed in a hospital-setting.
  
  
  OBJECTIVE
  We evaluated the age-dependent change of AD symptoms at an individual level in a community-setting.
  
  
  METHODS
  For the diagnostic accuracy, all participants of schoolchildren were received skin examination by dermatologists (twice a year for the same group), instead of questionnaire-based surveys. For this study, sequential check-ups of 273 elementary school children, aged 7~8 years, were performed for 4 years up to the age of 10~11 years.
  
  
  RESULTS
  Among the 47 AD children, who had been diagnosed as having AD at the first-year check-up, spontaneous remission was detected in nine children during the follow-up periods (remission rate of 19.1%). As a consequence, the one-year AD prevalence was decreased by 5.9% in the elementary schoolchildren over four years. Unexpectedly, late onset (after 8 years of age) AD was observed in 21.7% of AD children. There was no statistically significant relationship between spontaneous remission and host factors including sex and family history of atopic diseases.
  
  
  CONCLUSIONS
  We observed that 19.1% of AD children in the age group of 7~11 years showed spontaneous remission based on skin examination by dermatologists. There might be an increase in the prevalence of late onset AD in Korea.
authors.affiliation: Department of Dermatology, Chonnam National University Medical School, Gwangju, Korea.
authors.forename: Young Jee
authors.initials: YJ
authors.lastname: Kim
authors.affiliation: Department of Dermatology, Chonnam National University Medical School, Gwangju, Korea.
authors.forename: Sook Jung
authors.initials: SJ
authors.lastname: Yun
authors.affiliation: Department of Dermatology, Chonnam National University Medical School, Gwangju, Korea.
authors.forename: Jee-Bum
authors.initials: JB
authors.lastname: Lee
authors.affiliation: Department of Dermatology, Chonnam National University Medical School, Gwangju, Korea.
authors.forename: Seong Jin
authors.initials: SJ
authors.lastname: Kim
authors.affiliation: Department of Dermatology, Chonnam National University Medical School, Gwangju, Korea.
authors.forename: Young Ho
authors.initials: YH
authors.lastname: Won
authors.affiliation: Department of Dermatology, Chonnam National University Medical School, Gwangju, Korea.
authors.forename: Seung-Chul
authors.initials: SC
authors.lastname: Lee
keywords: Age-dependent change; Childhood atopic dermatitis; Dermatologists' skin examination; Spontaneous remission