title: [Intensive care treatment after aneurysmal subarachnoid hemorrhage].
abstract: Aneurysmal subarachnoid hemorrhage (SAH) is a devastating disease and nearly one third of patients die in the acute phase. Due to the bleeding event, a hyperactive sympathetic nervous system and an uncontrolled inflammatory response have a profound local and systemic impact on other organ functions. Neuroendocrinological disorders and cardiopulmonary morbidity are dominant. Despite a decrease in hospital mortality for high volume centers, a high proportion of survivors suffer from neurological deficits. Knowledge of the pathophysiology of vasospasms in the later stages of the disease has increased. Anti-inflammatory treatment does not improve the outcome. Nimodipine prophylaxis in the first 96 h after SAH seems to be the only intervention which has been proven to be advantageous in studies; however, nearly every second survivor of SAH suffers from some neurological deficits and more than one third of survivors report depressive episodes or symptoms of posttraumatic stress disorder.
authors.affiliation: Klinik für Anästhesiologie und Operative Intensivtherapie, Klinikum Augsburg, Stenglinstr. 2, 86156, Augsburg, Deutschland. Ulrich.Jaschinski@klinikum-augsburg.de.
authors.forename: U
authors.initials: U
authors.lastname: Jaschinski
mesh_terms: D003422:Critical Care / Q000379:methods*; D006801:Humans; D011182:Postoperative Care / Q000379:methods*; D011183:Postoperative Complications / Q000628:therapy*; D013345:Subarachnoid Hemorrhage / Q000150:complications / Q000601:surgery* / Q000628:therapy*; D020301:Vasospasm, Intracranial / Q000209:etiology / Q000628:therapy
keywords: Autoregulation; Cortical spreading depression; Ischemia; Stroke; Vasospasm