title: Effects of Ramipril and Telmisartan on Plasma Concentrations of Low Molecular Weight and Protein Thiols and Carotid Intima Media Thickness in Patients with Chronic Kidney Disease.
abstract: Hypertension, a common feature in chronic kidney disease (CKD), is an independent risk factor for CKD progression and cardiovascular disease. Although inhibitors of the renin-angiotensin system (RAS) exert salutary effects on blood pressure control and proteinuria in CKD patients, their activity towards traditional and novel oxidative markers is largely unknown. We studied the effects of 6-month treatment with telmisartan versus a combination of telmisartan and ramipril on plasma concentrations of low molecular mass (LMW, including homocysteine and cysteine) and protein thiols (PSH) plasma concentration and their relationships with carotid intima media thickness (IMT), in 24 hypertensive CKD patients (age 60 ± 12 years, 8 females and 16 males). Pretreatment PSH concentrations were independently associated with IMT (r= -0.42,p= 0.039). Neither treatment affected plasma LMW thiols, in both reduced and total form. By contrast, both treatments increased PSH plasma concentrations and reduced IMT, although significant differences were only observed in the combined treatment group. Our results suggest that the beneficial effects of combined RAS inhibitor treatment on IMT in hypertensive CKD patients may be mediated by a reduction of oxidative stress markers, particularly PSH.
authors.affiliation: Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy.
authors.forename: Angelo
authors.identifier: 0000-0002-8396-0968
authors.initials: A
authors.lastname: Zinellu
authors.affiliation: Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy.
authors.forename: Salvatore
authors.identifier: 0000-0002-3717-3437
authors.initials: S
authors.lastname: Sotgia
authors.affiliation: Department of Clinical Pharmacology, School of Medicine, Flinders University, Bedford Park, SA 5042, Australia.
authors.forename: Arduino A
authors.identifier: 0000-0001-8699-1412
authors.initials: AA
authors.lastname: Mangoni
authors.affiliation: Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy.
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Sotgiu
authors.affiliation: Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy.
authors.forename: Sara
authors.initials: S
authors.lastname: Ena
authors.affiliation: Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy.
authors.forename: Dionigia
authors.initials: D
authors.lastname: Arru
authors.affiliation: Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Assaretti
authors.affiliation: Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy.
authors.forename: Angela
authors.initials: A
authors.lastname: Baralla
authors.affiliation: Department of Surgical, Microsurgical and Medical Sciences, University of Sassari, 07100 Sassari, Italy.
authors.forename: Andrea E
authors.initials: AE
authors.lastname: Satta
authors.affiliation: Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy.
authors.forename: Ciriaco
authors.identifier: 0000-0002-6985-4907
authors.initials: C
authors.lastname: Carru
mesh_terms: D000368:Aged; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D001565:Benzoates / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D002339:Carotid Arteries / Q000187:drug effects; D003545:Cysteine / Q000097:blood; D004338:Drug Combinations; D005260:Female; D006710:Homocysteine / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D017257:Ramipril / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D051436:Renal Insufficiency, Chronic / Q000097:blood / Q000188:drug therapy*; D000077333:Telmisartan; D017539:Tunica Intima / Q000187:drug effects
chemical_list: D000959:Antihypertensive Agents; D001562:Benzimidazoles; D001565:Benzoates; D004338:Drug Combinations; D006710:Homocysteine; D003545:Cysteine; D017257:Ramipril; D000077333:Telmisartan