title: Heterotopic Abdominal Rat Heart Transplantation as a Model to Investigate Volume Dependency of Myocardial Remodeling.
abstract: Heterotopic abdominal rat heart transplantation has been extensively used to investigate ischemic-reperfusion injury, immunological consequences during heart transplantations and also to study remodeling of the myocardium due to volume unloading. We provide a unique review on the latter and present a summary of the experimental studies on rat heart transplantation to illustrate changes that occur to the myocardium due to volume unloading. We divided the literature based on whether normal or failing rat heart models were used. This analysis may provide a basis to understand the physiological effects of mechanical circulatory support therapy.
authors.affiliation: 1 Heart and Vascular Center, Semmelweis University, Budapest, Hungary. 2 Department of Cardiac Surgery, University of Heidelberg, Heidelberg, Germany.
authors.forename: Kálmán
authors.initials: K
authors.lastname: Benke
authors.forename: Alex Ali
authors.initials: AA
authors.lastname: Sayour
authors.forename: Csaba
authors.initials: C
authors.lastname: Mátyás
authors.forename: Bence
authors.initials: B
authors.lastname: Ágg
authors.forename: Balázs Tamás
authors.initials: BT
authors.lastname: Németh
authors.forename: Attila
authors.initials: A
authors.lastname: Oláh
authors.forename: Mihály
authors.initials: M
authors.lastname: Ruppert
authors.forename: István
authors.initials: I
authors.lastname: Hartyánszky
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Szabolcs
authors.forename: Tamás
authors.initials: T
authors.lastname: Radovits
authors.forename: Béla
authors.initials: B
authors.lastname: Merkely
authors.forename: Gábor
authors.initials: G
authors.lastname: Szabó
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006333:Heart Failure / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D016027:Heart Transplantation / Q000009:adverse effects* / Q000379:methods; D006353:Heart-Assist Devices; D015428:Myocardial Reperfusion Injury / Q000209:etiology* / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D009206:Myocardium / Q000378:metabolism / Q000473:pathology*; D051381:Rats; D016042:Transplantation, Heterotopic; D016277:Ventricular Function, Left; D020257:Ventricular Remodeling