title: Necroptosis in amyotrophic lateral sclerosis and other neurological disorders.
abstract: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by the progressive degeneration of upper and lower motor neurons. Cell death in ALS and in general was previously believed to exist as a dichotomy between apoptosis and necrosis. Most research investigating cell death mechanisms in ALS was conducted before the discovery of programmed necrosis thus did not use selective cell death pathway-specific markers. Recently, a new form of programmed cell death, termed "necroptosis", has been characterized and has been recently implicated in ALS as a primary mechanism driving motor neuron cell death in different forms of ALS. The present review is aimed at summarizing cell death pathways that are currently implicated in ALS and highlighting the emerging evidence on necroptosis as a major driver of motor neuron cell death.
authors.affiliation: Department of Pathology, University of British Columbia, 828 W. 10th Ave, Vancouver, BC V5Z 1L8, Canada.
authors.forename: Jessica R
authors.initials: JR
authors.lastname: Morrice
authors.affiliation: Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, BC, Canada.
authors.forename: Cheryl Y
authors.initials: CY
authors.lastname: Gregory-Evans
authors.affiliation: Department of Pathology, University of British Columbia, 828 W. 10th Ave, Vancouver, BC V5Z 1L8, Canada; Program in Experimental Medicine, University of British Columbia, Vancouver, BC, Canada; Program in Neuroscience, University of British Columbia, Vancouver, BC, Canada; Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, BC, Canada. Electronic address: cashawlab@gmail.com.
authors.forename: Christopher A
authors.initials: CA
authors.lastname: Shaw
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000378:metabolism / Q000473:pathology*; D000818:Animals; D016923:Cell Death; D006801:Humans; D009336:Necrosis / Q000378:metabolism / Q000473:pathology*; D019636:Neurodegenerative Diseases / Q000378:metabolism / Q000473:pathology; D009474:Neurons / Q000378:metabolism / Q000473:pathology*; D015398:Signal Transduction
keywords: ALS; Necroptosis; Programmed cell death