title: [Single nucleotide polymorphisms in genes of endothelin-1 and receptor A associated to cardiovascular in essential hypertension].
abstract: BACKGROUND
  The endothelin system, for its vasoconstrictor action, is related to the development of essential hypertension (HTAe). The polymorphism analysis of their genes represents a new approach to the study of this disease. We propose to analyze the interaction between stages of essential hypertension (HTAe) and risk factors with polymorphisms 138ex1 ins/del A gene endothelin-1 (ET-1) and H323H receptor gene A ET-1 (ETRA).
  
  
  METHODS
  We included 300 patients of both sexes, unrelated, who consecutively attended the clinic hypertension medical service. Each one underwent a complete physical examination, electrocardiogram, echocardiogram, and Rx thorax. The degree of severity of hypertension was determined in stages. The determination of polymorphisms was performed by amplification followed by cutting by specific restriction enzyme from DNA obtained from peripheral blood.
  
  
  RESULTS
  The 46% of patients had HTAe controlled, 17.6% had organ damage or cardiovascular, brain or kidney disease. It was observed that the 4A/4A carriers showed lower frequency of cardiovascular disease, kidney and brain (P<.032; 95% CI: 11.1-21.4). For H323H polymorphism, the evaluation by images showed a higher frequency of the dilations of left auricular (P=.02) and auricular fibrillation (P=.03) between the T/T carrier, a higher frequency of cardiomegaly was detected in C/C patients (P=.04).
  
  
  CONCLUSIONS
  The genotypes, 4A/4A of the ET-1 gene and the T/T from ETRA gene might be involved in worse outcome of cardiovascular damage. Their identification could help recognize subgroups of the hypertensive patients with different risk.
authors.affiliation: Servicio de Cardiología, Hospital Córdoba, Córdoba, Argentina.
authors.forename: S R
authors.initials: SR
authors.lastname: Tamiozzo
authors.affiliation: Servicio de Cardiología, Hospital Córdoba, Córdoba, Argentina; Cátedra de Semiología I, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, Argentina.
authors.forename: O C
authors.initials: OC
authors.lastname: Lassen
authors.affiliation: Cátedra de Bioquímica y Biología Molecular, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, Argentina.
authors.forename: J
authors.initials: J
authors.lastname: Herrera
authors.affiliation: Servicio de Cardiología, Hospital Córdoba, Córdoba, Argentina.
authors.forename: P
authors.initials: P
authors.lastname: Igarzabal
authors.affiliation: Cátedra de Bioquímica y Biología Molecular, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, Argentina.
authors.forename: S
authors.initials: S
authors.lastname: Tabares
authors.affiliation: Cátedra de Bioquímica y Biología Molecular, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, Argentina. Electronic address: asembaj@biomed.uncor.edu.
authors.forename: A
authors.initials: A
authors.lastname: Sembaj
mesh_terms: D000368:Aged; D001118:Argentina / Q000453:epidemiology; D001145:Arrhythmias, Cardiac / Q000209:etiology; D006332:Cardiomegaly / Q000209:etiology; D019332:Endothelin-1 / Q000235:genetics* / Q000502:physiology; D000075222:Essential Hypertension / Q000150:complications / Q000235:genetics* / Q000473:pathology; D005260:Female; D056726:Genetic Association Studies; D006321:Heart / Q000503:physiopathology*; D006339:Heart Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology*; D020641:Polymorphism, Single Nucleotide; D044022:Receptor, Endothelin A / Q000235:genetics* / Q000502:physiology; D012307:Risk Factors; D012720:Severity of Illness Index; D013318:Stroke Volume
chemical_list: D019332:Endothelin-1; D044022:Receptor, Endothelin A
keywords: Endotelina-1, Receptor A de endotelina-1; Endothelin-1, Receptor A of endothelin-1; Essential hypertension; Genetic polymorphisms; Hipertensión arterial esencial; Polimorfismos genéticos