title: Role of Osteogenic Growth Peptide (OGP) and OGP(10-14) in Bone Regeneration: A Review.
abstract: Bone regeneration is a process that involves several molecular mediators, such as growth factors, which directly affect the proliferation, migration and differentiation of bone-related cells. The osteogenic growth peptide (OGP) and its C-terminal pentapeptide OGP(10-14) have been shown to stimulate the proliferation, differentiation, alkaline phosphatase activity and matrix mineralization of osteoblastic lineage cells. However, the exact molecular mechanisms that promote osteoblastic proliferation and differentiation are not completely understood. This review presents the main chemical characteristics of OGP and/or OGP(10-14), and also discusses the potential molecular pathways induced by these growth factors to promote proliferation and differentiation of osteoblasts. Furthermore, since these peptides have been extensively investigated for bone tissue engineering, the clinical applications of these peptides for bone regeneration are discussed.
authors.affiliation: Department of Diagnosis and Surgery, School of Dentistry at Araraquara, UNESP-São Paulo State University, Humaita St, 1680, CEP 14801-903 Araraquara, São Paulo, Brazil. supigossi@ymail.com.|Department of Morphology, School of Dentistry, UNESP- São Paulo State University, Humaita St, 1680, CEP 14801-903 Araraquara, São Paulo, Brazil. supigossi@ymail.com.
authors.forename: Suzane C
authors.initials: SC
authors.lastname: Pigossi
authors.affiliation: Department of Diagnosis and Surgery, School of Dentistry at Araraquara, UNESP-São Paulo State University, Humaita St, 1680, CEP 14801-903 Araraquara, São Paulo, Brazil. marcellmedeiros@gmail.com.
authors.forename: Marcell C
authors.initials: MC
authors.lastname: Medeiros
authors.affiliation: Department of General and Inorganic Chemistry, Institute of Chemistry, UNESP-São Paulo State University, Professor Francisco Degni St, 55, CEP 14800-900 Araraquara, São Paulo, Brazil. sysaska@gmail.com.
authors.forename: Sybele
authors.initials: S
authors.lastname: Saska
authors.affiliation: Department of Diagnosis and Surgery, School of Dentistry at Araraquara, UNESP-São Paulo State University, Humaita St, 1680, CEP 14801-903 Araraquara, São Paulo, Brazil. cirelli@foar.unesp.br.
authors.forename: Joni A
authors.initials: JA
authors.lastname: Cirelli
authors.affiliation: Department of Diagnosis and Surgery, School of Dentistry at Araraquara, UNESP-São Paulo State University, Humaita St, 1680, CEP 14801-903 Araraquara, São Paulo, Brazil. raquel@foar.unesp.br.|Department of Morphology, School of Dentistry, UNESP- São Paulo State University, Humaita St, 1680, CEP 14801-903 Araraquara, São Paulo, Brazil. raquel@foar.unesp.br.
authors.forename: Raquel M
authors.initials: RM
authors.lastname: Scarel-Caminaga
mesh_terms: D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D001861:Bone Regeneration / Q000187:drug effects*; D001842:Bone and Bones / Q000187:drug effects* / Q000293:injuries / Q000378:metabolism; D002454:Cell Differentiation / Q000187:drug effects; D002465:Cell Movement / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D015870:Gene Expression; D006657:Histones / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism / Q000494:pharmacology*; D009842:Oligopeptides / Q000138:chemical synthesis / Q000494:pharmacology*; D010006:Osteoblasts / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D010012:Osteogenesis / Q000187:drug effects
chemical_list: D006657:Histones; D036341:Intercellular Signaling Peptides and Proteins; D009842:Oligopeptides; C074533:osteogenic growth peptide; D000469:Alkaline Phosphatase
keywords: biocompatible materials; bone regeneration; osteoblasts; osteogenic growth peptide