title: Immune function parameters as markers of biological age and predictors of longevity.
abstract: Chronological age is not a good indicator of how each individual ages and thus how to maintain good health. Due to the long lifespan in humans and the consequent difficulty of carrying out longitudinal studies, finding valid biomarkers of the biological age has been a challenge both for research and clinical studies. The aim was to identify and validate several immune cell function parameters as markers of biological age. Adult, mature, elderly and long-lived human volunteers were used. The chemotaxis, phagocytosis, natural killer activity and lymphoproliferation in neutrophils and lymphocytes of peripheral blood were analyzed. The same functions were measured in peritoneal immune cells from mice, at the corresponding ages (adult, mature, old and long lived) in a longitudinal study. The results showed that the evolution of these functions was similar in humans and mice, with a decrease in old subjects. However, the long-lived individuals maintained values similar to those in adults. In addition, the values of these functions in adult prematurely aging mice were similar to those in chronologically old animals, and they died before their non-prematurely aging mice counterparts. Thus, the parameters studied are good markers of the rate of aging, allowing the determination of biological age.
authors.affiliation: Department of Animal Physiology II, Faculty of Biology, Complutense University, Madrid, Spain.|Institute of Investigation, Hospital 12 Octubre, Madrid, Spain.
authors.forename: Irene
authors.initials: I
authors.lastname: Martínez de Toda
authors.affiliation: Department of Animal Physiology II, Faculty of Biology, Complutense University, Madrid, Spain.|Institute of Investigation, Hospital 12 Octubre, Madrid, Spain.
authors.forename: Ianire
authors.initials: I
authors.lastname: Maté
authors.affiliation: Department of Animal Physiology II, Faculty of Biology, Complutense University, Madrid, Spain.|Institute of Investigation, Hospital 12 Octubre, Madrid, Spain.
authors.forename: Carmen
authors.initials: C
authors.lastname: Vida
authors.affiliation: Department of Animal Physiology II, Faculty of Biology, Complutense University, Madrid, Spain.|Institute of Investigation, Hospital 12 Octubre, Madrid, Spain.
authors.forename: Julia
authors.initials: J
authors.lastname: Cruces
authors.affiliation: Department of Animal Physiology II, Faculty of Biology, Complutense University, Madrid, Spain.|Institute of Investigation, Hospital 12 Octubre, Madrid, Spain.
authors.forename: Mónica
authors.initials: M
authors.lastname: De la Fuente
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000276:immunology*; D019588:Aging, Premature / Q000276:immunology; D000818:Animals; D005260:Female; D006801:Humans; D008136:Longevity / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D051379:Mice; D008875:Middle Aged; D009504:Neutrophils / Q000276:immunology; D018384:Oxidative Stress / Q000276:immunology; D010587:Phagocytosis / Q000276:immunology
keywords: aging; biological age; biomarker; immune function; longevity