title: Selective serotonin reuptake inhibitors and risk of major congenital anomalies for pregnancies in Japan: A nationwide birth cohort study of the Japan Environment and Children's Study.
abstract: We analyzed data from the Japan Environment and Children's Study (JECS), on the association between selective serotonin reuptake inhibitors (SSRI) use during pregnancy and the risk of developing of major congenital anomalies in Japan. JECS is an ongoing nationwide birth cohort study. The study includes 95 994 single pregnant women and their offspring. Among them, 172 used any SSRI up to the 12thgestational week. Crude analyses show a significantly increased incidence of upper limb, abdominal, and urogenital abnormalities. In particular, the incidence of microcephaly, hydrencephalus, esophageal atresia, small intestinal atresia, and achondroplasia was significantly higher with than without exposure to these substances. On multivariate analyses, urogenital abnormality was significant (odds ratio 3.227; 95% confidence interval: 1.460-7.134). This Japanese nationwide birth cohort survey clarified that the use of any SSRI until the 12thgestational week was associated with urogenital abnormality in children. The survey for association with minor classification abnormality needs further examination in Japan.
authors.affiliation: Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Miyagi, Japan.|Environment and Genome Research Center, Tohoku University Graduate School of Medicine, Miyagi, Japan.
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Nishigori
authors.affiliation: Pharmaceutical Sciences, Tohoku University Hospital, Miyagi, Japan.|Environment and Genome Research Center, Tohoku University Graduate School of Medicine, Miyagi, Japan.|Tohoku Medical Megabank Organization, Tohoku University, Miyagi, Japan.
authors.forename: Taku
authors.initials: T
authors.lastname: Obara
authors.affiliation: Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Miyagi, Japan.
authors.forename: Toshie
authors.initials: T
authors.lastname: Nishigori
authors.affiliation: Environment and Genome Research Center, Tohoku University Graduate School of Medicine, Miyagi, Japan.|Tohoku Medical Megabank Organization, Tohoku University, Miyagi, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Mizuno
authors.affiliation: Tohoku Medical Megabank Organization, Tohoku University, Miyagi, Japan.|Department of Public Health and Hygiene, Tohoku Medical and Pharmaceutical University School of Medicine, Miyagi, Japan.
authors.forename: Hirohito
authors.initials: H
authors.lastname: Metoki
authors.affiliation: Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Miyagi, Japan.
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Hoshiai
authors.affiliation: Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Miyagi, Japan.
authors.forename: Zen
authors.initials: Z
authors.lastname: Watanabe
authors.affiliation: Environment and Genome Research Center, Tohoku University Graduate School of Medicine, Miyagi, Japan.
authors.forename: Kasumi
authors.initials: K
authors.lastname: Sakurai
authors.affiliation: Tohoku Medical Megabank Organization, Tohoku University, Miyagi, Japan.
authors.forename: Mami
authors.initials: M
authors.lastname: Ishikuro
authors.affiliation: Environment and Genome Research Center, Tohoku University Graduate School of Medicine, Miyagi, Japan.
authors.forename: Nozomi
authors.initials: N
authors.lastname: Tatsuta
authors.affiliation: Environment and Genome Research Center, Tohoku University Graduate School of Medicine, Miyagi, Japan.|Tohoku Medical Megabank Organization, Tohoku University, Miyagi, Japan.
authors.forename: Ichiko
authors.initials: I
authors.lastname: Nishijima
authors.affiliation: Environment and Genome Research Center, Tohoku University Graduate School of Medicine, Miyagi, Japan.
authors.forename: Ikuma
authors.initials: I
authors.lastname: Fujiwara
authors.affiliation: Environment and Genome Research Center, Tohoku University Graduate School of Medicine, Miyagi, Japan.|Tohoku Medical Megabank Organization, Tohoku University, Miyagi, Japan.|International Research Institute of Disaster Science, Tohoku University, Miyagi, Japan.
authors.forename: Shinichi
authors.initials: S
authors.lastname: Kuriyama
authors.affiliation: Environment and Genome Research Center, Tohoku University Graduate School of Medicine, Miyagi, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Arima
authors.affiliation: Environment and Genome Research Center, Tohoku University Graduate School of Medicine, Miyagi, Japan.
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Nakai
authors.affiliation: Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Miyagi, Japan.|Environment and Genome Research Center, Tohoku University Graduate School of Medicine, Miyagi, Japan.|Tohoku Medical Megabank Organization, Tohoku University, Miyagi, Japan.
authors.forename: Nobuo
authors.initials: N
authors.lastname: Yaegashi
mesh_terms: D000293:Adolescent; D000328:Adult; D015331:Cohort Studies; D000013:Congenital Abnormalities / Q000453:epidemiology* / Q000209:etiology*; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D016015:Logistic Models; D008875:Middle Aged; D016017:Odds Ratio; D011159:Population Surveillance; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology* / Q000209:etiology*; D012306:Risk; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects*; D055815:Young Adult
chemical_list: D017367:Selective Serotonin Reuptake Inhibitors
keywords: Japan Environment and Children's Study; major congenital anomalies; selective serotonin reuptake inhibitors