title: Redox control of senescence and age-related disease.
abstract: The signaling networks that drive the aging process, associated functional deterioration, and pathologies has captured the scientific community's attention for decades. While many theories exist to explain the aging process, the production of reactive oxygen species (ROS) provides a signaling link between engagement of cellular senescence and several age-associated pathologies. Cellular senescence has evolved to restrict tumor progression but the accompanying senescence-associated secretory phenotype (SASP) promotes pathogenic pathways. Here, we review known biological theories of aging and how ROS mechanistically control senescence and the aging process. We also describe the redox-regulated signaling networks controlling the SASP and its important role in driving age-related diseases. Finally, we discuss progress in designing therapeutic strategies that manipulate the cellular redox environment to restrict age-associated pathology.
authors.affiliation: SUNY Polytechnic Institute, Colleges of Nanoscale Science and Engineering, 257 Fuller Road, Albany, NY 12203, USA.
authors.forename: Akshaya
authors.initials: A
authors.lastname: Chandrasekaran
authors.affiliation: SUNY Polytechnic Institute, Colleges of Nanoscale Science and Engineering, 257 Fuller Road, Albany, NY 12203, USA.
authors.forename: Maria Del Pilar Sosa
authors.initials: MDPS
authors.lastname: Idelchik
authors.affiliation: SUNY Polytechnic Institute, Colleges of Nanoscale Science and Engineering, 257 Fuller Road, Albany, NY 12203, USA. Electronic address: jmelendez@sunypoly.edu.
authors.forename: J Andrés
authors.initials: JA
authors.lastname: Melendez
mesh_terms: D000375:Aging / Q000235:genetics* / Q000473:pathology; D016922:Cellular Senescence / Q000235:genetics*; D006801:Humans; D010084:Oxidation-Reduction; D017382:Reactive Oxygen Species / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D017382:Reactive Oxygen Species
keywords: Aging; Oxidative stress; Reactive oxygen species (ROS); Senescence; Senescence-associated secretory phenotype (SASP)