title: Comprehensive Assessment of Compliance with Antimuscarinic Drug Treatment in the Case of Urge Urinary Incontinence of Older Patients.
abstract: To investigate the heterogeneous factors affecting the stability of patients older than 60 years in the UI treatment with Antimuscarinics.
  
  
  
  The prevalence of Urge Incontinence (UI) in older persons reaches 29.3%. The symptoms of urinary incontinence in older people reduce the health related life quality.
  
  
  
  In 1257 patients over 60 years (857 (68.2%) women - average age 67.8, 400 (31.8%) men - 71.4), who received AM for one year, demographic, socio-economic and health parameters were studied. OABq-SF questionnaires, MOS SF-36, urination diaries, uroflowmetry, income information from the tax offices and outpatient records were used.
  
  
  
  The compliance to AM treatment within 6 months was retained in 44.2%, and within the year - 26.8% of older patients. At least 40% of the total number of patients refused to continue the treatment for medical reasons. The persons taking Solifenacin (p≤ 0.01), Trospium (p≤ 0.05), or Darifenacin (p≤ 0.05), suffering from severe UI symptoms (p≤ 0.01), and experiencing minor side effects (p≤ 0.01), well-informed about UI treatment methods (p≤ 0.01) prevailed among the treatment compliant patients. At least 20.4% of the patients discontinued their treatment due to economic reasons. The persons with significantly larger annual income (p≤ 0.05) and annual medical cost (p≤ 0.01) prevailed among the treatment compliant patients. About 12.2% of the patients stopped their treatment for reasons related to the social background and psychological status.
  
  
  
  In this experiment, we found that AM treatment compliance in older patients, in addition to medical parameters and health conditions, is largely affected by the economic as well as social, demographic and psychological factors. The study results can be claimed by practitioners involved in correcting UI symptoms in older people.
authors.affiliation: Far Eastern Federal University, Ajax 10, corp.F, office 733, Vladivostok, Primorsky region, Russian Federation.
authors.forename: Kirill V
authors.initials: KV
authors.lastname: Kosilov
authors.affiliation: Department of Urology, City Polyclinic No 3, Vladivostok, Primorsky Region, Russian Federation.
authors.forename: Sergey A
authors.initials: SA
authors.lastname: Loparev
authors.affiliation: Department of Social Science, Far Eastern Federal University, Vladivostok, Primorsky Region, Russian Federation.
authors.forename: Irina G
authors.initials: IG
authors.lastname: Kuzina
authors.affiliation: Department of Theory and Methods of Adaptive Physical Education, Far Eastern Federal University, Vladivostok, Primorsky Region, Russian Federation.
authors.forename: Olga V
authors.initials: OV
authors.lastname: Shakirova
authors.affiliation: Department of Theory and Methods of Adaptive Physical Education, Far Eastern Federal University, Vladivostok, Primorsky Region, Russian Federation.
authors.forename: Natalya S
authors.initials: NS
authors.lastname: Zhuravskaya
authors.affiliation: Institute of Humanities, Far Eastern Federal University, Vladivostok, Primorsky Region, Russian Federation.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Lobodenko
mesh_terms: D000367:Age Factors; D000368:Aged; D000375:Aging / Q000523:psychology*; D016527:Drug Costs; D005260:Female; D005102:Health Expenditures; D006801:Humans; D008297:Male; D008499:Medical Records; D055118:Medication Adherence; D008875:Middle Aged; D018727:Muscarinic Antagonists / Q000009:adverse effects / Q000191:economics / Q000627:therapeutic use*; D012307:Risk Factors; D012426:Russia; D012959:Socioeconomic Factors; D011795:Surveys and Questionnaires; D013997:Time Factors; D016896:Treatment Outcome; D001743:Urinary Bladder / Q000187:drug effects* / Q000503:physiopathology; D053202:Urinary Incontinence, Urge / Q000188:drug therapy* / Q000191:economics / Q000503:physiopathology / Q000523:psychology; D014563:Urodynamics / Q000187:drug effects
chemical_list: D018727:Muscarinic Antagonists
keywords: Adherence; antimuscarinic; older; treatment; urinary incontinence; urination diaries; urodynamics; uroflowmetry