title: Natural products as mediators of disease.
abstract: Covering: up to 2016Humans are walking microbial ecosystems, each harboring a complex microbiome with the genetic potential to produce a vast array of natural products. Recent sequencing data suggest that our microbial inhabitants are critical for maintaining overall health. Shifts in microbial communities have been correlated to a number of diseases including infections, inflammation, cancer, and neurological disorders. Some of these clinically and diagnostically relevant phenotypes are a result of the presence of small molecules, yet we know remarkably little about their contributions to the health of individuals. Here, we review microbe-derived natural products as mediators of human disease.
authors.affiliation: Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, La Jolla, San Diego, CA 92093, USA. pdorrestein@ucsd.edu vanessa.phelan@ucdenver.edu.
authors.forename: Neha
authors.initials: N
authors.lastname: Garg
authors.forename: Tal
authors.initials: T
authors.lastname: Luzzatto-Knaan
authors.forename: Alexey V
authors.initials: AV
authors.lastname: Melnik
authors.forename: Andrés Mauricio
authors.initials: AM
authors.lastname: Caraballo-Rodríguez
authors.forename: Dimitrios J
authors.initials: DJ
authors.lastname: Floros
authors.forename: Daniel
authors.initials: D
authors.lastname: Petras
authors.forename: Rachel
authors.initials: R
authors.lastname: Gregor
authors.forename: Pieter C
authors.initials: PC
authors.lastname: Dorrestein
authors.forename: Vanessa V
authors.initials: VV
authors.lastname: Phelan
mesh_terms: D001688:Biological Products / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D064307:Microbiota; D015394:Molecular Structure
chemical_list: D001688:Biological Products