title: High prevalence of anti-TSH receptor antibody in fibromyalgia syndrome.
abstract: OBJECTIVE
  Fibromyalgia syndrome (FMS) is defined as chronic widespread pain that cannot be accounted for by any other medical disorder. Our aim was to explore the prevalence of thyroid autoimmunity in patients with FMS.
  
  
  METHODS
  For determining thyroid function in 207 FMS patients, we tested for the titers of free tri-iodothyronine, free thyroxine, thyroid-stimulating hormone (TSH), anti-thyroid peroxidase antibody (TPOAb), anti-thyroglobulin antibody (TgAb) and anti-TSH receptor antibody (TRAb).
  
  
  RESULTS
  Twenty-five patients who had either subclinical hyper- or hypothyroidism, or overt hypothyroidism were excluded. Sixty-nine FMS patients with autoimmune thyroid diseases (AITD) (37.9%, 69/182) were identified. The prevalence of positivity for TRAb, TgAb and TPOAb was 20.3% (n = 37), 16.5% (n = 30) and 13.2% (n = 24), respectively. Compared to control populations in previous studies, the prevalence of TRAb positivity was high, and titers of TRAb were low (1.0-1.5 IU/L). The prevalence of TPOAb and TgAb positivity was not significantly higher than that reported in FMS patients in previous studies. Clinical symptom profiles were identical for FMS patients with and without AITD.
  
  
  CONCLUSIONS
  We found a high prevalence of AITD among 207 patients with clinically defined FMS, with TRAb being especially prominent among these patients. Further study is needed to evaluate changes in thyroid function among FMS patients with AITD.
authors.affiliation: Department of Neurology, Juntendo University Graduate School of Medicine, Tokyo, Japan.
authors.forename: Kenya
authors.initials: K
authors.lastname: Nishioka
authors.affiliation: Department of Metabolism and Endocrinology, Juntendo University Graduate School of Medicine, Tokyo, Japan.
authors.forename: Toyoyoshi
authors.initials: T
authors.lastname: Uchida
authors.affiliation: Department of Psychiatry, Juntendo Nerima Hospital, Tokyo, Japan.
authors.forename: Chie
authors.initials: C
authors.lastname: Usui
authors.affiliation: Department of Neurology, Juntendo University Graduate School of Medicine, Tokyo, Japan.
authors.forename: Ryota
authors.initials: R
authors.lastname: Tanaka
authors.affiliation: Department of Neurology, Juntendo University Graduate School of Medicine, Tokyo, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Matsushima
authors.affiliation: Department of Rheumatology, Kuwana City Medical Center, Tokyo, Mie, Japan.
authors.forename: Yoshifuji
authors.initials: Y
authors.lastname: Matsumoto
authors.affiliation: Research Center for Rheumatic disease, Toranomonkai Medical Corporation, Tokyo, Japan.
authors.forename: Ikuro
authors.initials: I
authors.lastname: Nakamura
authors.affiliation: Research Center for Rheumatic disease, Toranomonkai Medical Corporation, Tokyo, Japan.|Department of Rheumatology, Institute of Medical Science, Tokyo Medical University, Tokyo, Japan.
authors.forename: Kusuki
authors.initials: K
authors.lastname: Nishioka
authors.affiliation: Department of Neurology, Juntendo University Graduate School of Medicine, Tokyo, Japan.
authors.forename: Nobutaka
authors.initials: N
authors.lastname: Hattori
mesh_terms: D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000097:blood; D015551:Autoimmunity; D015415:Biomarkers / Q000097:blood; D005260:Female; D005356:Fibromyalgia / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology*; D006801:Humans; D018828:Immunoglobulins, Thyroid-Stimulating / Q000097:blood*; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011989:Receptors, Thyrotropin / Q000276:immunology*; D012189:Retrospective Studies; D016036:Seroepidemiologic Studies; D012698:Serologic Tests; D013577:Syndrome; D013960:Thyroid Function Tests; D013963:Thyroid Hormones / Q000097:blood; D013967:Thyroiditis, Autoimmune / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D015415:Biomarkers; D018828:Immunoglobulins, Thyroid-Stimulating; D011989:Receptors, Thyrotropin; D013963:Thyroid Hormones; C006606:anti-thyroglobulin; C056626:thyroid microsomal antibodies; C094372:thyrotropin-binding inhibitory immunoglobulin
keywords: TSH receptor antibody; autoimmune thyroid diseases; fibromyalgia; widespread pain