title: Synthesis and Biological Evaluation of Benzimidazole Phenylhydrazone Derivatives as Antifungal Agents against Phytopathogenic Fungi.
abstract: A series of benzimidazole phenylhydrazone derivatives (6a-6ai) were synthesized and characterized by ¹H-NMR, ESI-MS, and elemental analysis. The structure of6bwas further confirmed by single crystal X-ray diffraction as (E)-configuration. All the compounds were screened for antifungal activity againstRhizoctonia solaniandMagnaporthe oryzaeemploying a mycelium growth rate method. Compound6fexhibited significant inhibitory activity againstR. solaniandM. oryzaewith the EC50values of 1.20 and 1.85 μg/mL, respectively. In vivo testing demonstrated that6fcould effectively control the development of rice sheath blight (RSB) and rice blast (RB) caused by the above two phytopathogens. This work indicated that the compound6fwith a benzimidazole phenylhydrazone scaffold could be considered as a leading structure for the development of novel fungicides.
authors.affiliation: State & Local Joint Engineering Research Center of Green Pesticide Invention and Application, College of Plant Protection, Nanjing Agricultural University, Nanjing 210095, China. 2014102127@njau.edu.cn.|Key Laboratory of Integrated Management of Crop Diseases and Pests, Ministry of Education, Nanjing 210095, China. 2014102127@njau.edu.cn.
authors.forename: Xing
authors.initials: X
authors.lastname: Wang
authors.affiliation: State & Local Joint Engineering Research Center of Green Pesticide Invention and Application, College of Plant Protection, Nanjing Agricultural University, Nanjing 210095, China. 2013102122@njau.edu.cn.|Key Laboratory of Integrated Management of Crop Diseases and Pests, Ministry of Education, Nanjing 210095, China. 2013102122@njau.edu.cn.
authors.forename: Yong-Fei
authors.initials: YF
authors.lastname: Chen
authors.affiliation: State & Local Joint Engineering Research Center of Green Pesticide Invention and Application, College of Plant Protection, Nanjing Agricultural University, Nanjing 210095, China. yanwei@njau.edu.cn.|Key Laboratory of Integrated Management of Crop Diseases and Pests, Ministry of Education, Nanjing 210095, China. yanwei@njau.edu.cn.
authors.forename: Wei
authors.initials: W
authors.lastname: Yan
authors.affiliation: State & Local Joint Engineering Research Center of Green Pesticide Invention and Application, College of Plant Protection, Nanjing Agricultural University, Nanjing 210095, China. 2015202050@njau.edu.cn.|Key Laboratory of Integrated Management of Crop Diseases and Pests, Ministry of Education, Nanjing 210095, China. 2015202050@njau.edu.cn.
authors.forename: Ling-Ling
authors.initials: LL
authors.lastname: Cao
authors.affiliation: State & Local Joint Engineering Research Center of Green Pesticide Invention and Application, College of Plant Protection, Nanjing Agricultural University, Nanjing 210095, China. yeyh@njau.edu.cn.|Key Laboratory of Integrated Management of Crop Diseases and Pests, Ministry of Education, Nanjing 210095, China. yeyh@njau.edu.cn.
authors.forename: Yong-Hao
authors.initials: YH
authors.lastname: Ye
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006835:Hydrazones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D020082:Magnaporthe / Q000187:drug effects; D015394:Molecular Structure; D025282:Mycelium / Q000187:drug effects; D012275:Oryza / Q000187:drug effects / Q000382:microbiology; D010935:Plant Diseases / Q000382:microbiology / Q000517:prevention & control*; D012232:Rhizoctonia / Q000187:drug effects; D013329:Structure-Activity Relationship; D014961:X-Ray Diffraction
chemical_list: D000935:Antifungal Agents; D001562:Benzimidazoles; D006835:Hydrazones
keywords: antifungal activity; benzimidazole; phenylhydrazone