title: Advancement of mass spectrometry-based proteomics technologies to explore triple negative breast cancer.
abstract: Understanding the complexity of cancer biology requires extensive information about the cancer proteome over the course of the disease. The recent advances in mass spectrometry-based proteomics technologies have led to the accumulation of an incredible amount of such proteomic information. This information allows us to identify protein signatures or protein biomarkers, which can be used to improve cancer diagnosis, prognosis and treatment. For example, mass spectrometry-based proteomics has been used in breast cancer research for over two decades to elucidate protein function. Breast cancer is a heterogeneous group of diseases with distinct molecular features that are reflected in tumour characteristics and clinical outcomes. Compared with all other subtypes of breast cancer, triple-negative breast cancer is perhaps the most distinct in nature and heterogeneity. In this review, we provide an introductory overview of the application of advanced proteomic technologies to triple-negative breast cancer research.
authors.affiliation: Stowers Institute for Medical Research, 1000 E. 50th St, Kansas City, MO 64110, USA. mpw@stowers.org and Department of Biochemistry, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5E5, Canada.
authors.forename: Sayem
authors.initials: S
authors.lastname: Miah
authors.affiliation: Stowers Institute for Medical Research, 1000 E. 50th St, Kansas City, MO 64110, USA. mpw@stowers.org.
authors.forename: Charles A S
authors.initials: CA
authors.lastname: Banks
authors.affiliation: Stowers Institute for Medical Research, 1000 E. 50th St, Kansas City, MO 64110, USA. mpw@stowers.org.
authors.forename: Mark K
authors.initials: MK
authors.lastname: Adams
authors.affiliation: Stowers Institute for Medical Research, 1000 E. 50th St, Kansas City, MO 64110, USA. mpw@stowers.org.
authors.forename: Laurence
authors.initials: L
authors.lastname: Florens
authors.affiliation: Department of Biochemistry, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5E5, Canada.
authors.forename: Kiven E
authors.initials: KE
authors.lastname: Lukong
authors.affiliation: Stowers Institute for Medical Research, 1000 E. 50th St, Kansas City, MO 64110, USA. mpw@stowers.org and Departments of Pathology & Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USA.
authors.forename: Michael P
authors.initials: MP
authors.lastname: Washburn
mesh_terms: D005260:Female; D006801:Humans; D013058:Mass Spectrometry / Q000379:methods; D020543:Proteome; D040901:Proteomics / Q000379:methods; D012106:Research; D064726:Triple Negative Breast Neoplasms / Q000175:diagnosis / Q000209:etiology / Q000378:metabolism*
chemical_list: D020543:Proteome