title: Progressive muscle relaxation as a supportive intervention for cancer patients undergoing chemotherapy: A systematic review.
abstract: Many cancer patients use a wide variety of techniques to improve their physical and mental well-being, including relaxation therapy and, specifically, Progressive Muscle Relaxation (PMR). However, there is no strong evidence that supports the efficacy of this technique.
  
  
  
  Our aim was to review the evidence regarding the use of PMR as a supportive intervention for cancer patients undergoing chemotherapeutic treatment.
  
  
  
  Six databases were electronically searched: AMED, the Cochrane Library, MEDLINE, PsychINFO, Scopus, and the Web of Science. After removing duplicates, 700 publications were screened and 57 identified as potentially relevant. The flow of information from record identification to study inclusion was conducted in accordance with the PRISMA statement. Original articles published in peer-reviewed journals that studied the use of PMR as an intervention, were randomized or included a matched control group, and that included patients receiving chemotherapy were included. Studies that combined PMR with other interventions were excluded. The methodological quality of included trials was assessed using the Jadad Scale and the CONSORT guidelines.
  
  
  
  A total of 5 of the 57 papers fulfilled the preset criteria and were included in our systematic review. Our findings indicate that PMR might improve comfort and reduce the anxiety levels and side effects caused by chemotherapy, with the exception of vomiting. Nonetheless, the quality of all the included studies was extremely low.
  
  
  
  There is evidence that PMR might have a few benefits for patients undergoing chemotherapy. Still, the small number of studies included and their poor quality limit the significance of our results. Despite the fact that pharmaceutical approaches for controlling side effects might be reaching their full potential and that there might be further usefulness for such integrative treatments as PMR, the need to run more high-quality trials testing the efficacy of this technique is warranted before suggesting its adoption as part of standard cancer care.
authors.affiliation: Hematology-Oncology Unit,Fourth Department of Internal Medicine,Attikon Hospital,National and Kapodistrian University of Athens, Medical School,Athens,Greece.
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Pelekasis
authors.affiliation: Hematology-Oncology Unit,Fourth Department of Internal Medicine,Attikon Hospital,National and Kapodistrian University of Athens, Medical School,Athens,Greece.
authors.forename: Ifigeneia
authors.initials: I
authors.lastname: Matsouka
authors.affiliation: Hematology-Oncology Unit,Fourth Department of Internal Medicine,Attikon Hospital,National and Kapodistrian University of Athens, Medical School,Athens,Greece.
authors.forename: Anna
authors.initials: A
authors.lastname: Koumarianou
mesh_terms: D004358:Drug Therapy / Q000523:psychology*; D005081:Exercise Therapy / Q000379:methods / Q000592:standards*; D006801:Humans; D009126:Muscle Relaxation; D009369:Neoplasms / Q000523:psychology / Q000628:therapy*; D016896:Treatment Outcome
keywords: Anxiety; Cancer; Chemotherapy; Progressive muscle relaxation; Side effects