title: Development of a multi-wavelength diffuse optical tomography system for early diagnosis of rheumatoid arthritis: simulation, phantoms and healthy human studies.
abstract: A multi-wavelength diffuse optical tomography (DOT) system has been developed to directly extract physiological information, such as total haemoglobin concentration, from tissue in human hand joints. Novel methods for 3D surface imaging and spectrally constrained image reconstruction are introduced and their potential application to imaging of rheumatoid arthritis is discussed. Results are presented from simulation studies as well as experiments using phantoms and data from imaging of three healthy volunteers. The image features are recovered partially for phantom data using transmission measurements only. Images that reveal joint regions and surrounding features within the hand are shown to co-register with co-acquired ultrasound images which are shown to be related to total haemoglobin concentration.
authors.affiliation: The Centre for Physical Sciences of Imaging in Biomedical Sciences (PSIBS), University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
authors.forename: Hao Yang
authors.initials: HY
authors.lastname: Wu
authors.affiliation: The Rheumatology Research Group, School of Immunity and Infection, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
authors.forename: Andrew
authors.initials: A
authors.lastname: Filer
authors.affiliation: The Centre for Physical Sciences of Imaging in Biomedical Sciences (PSIBS), University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK; School of Computer Science, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
authors.forename: Iain
authors.initials: I
authors.lastname: Styles
authors.affiliation: The Centre for Physical Sciences of Imaging in Biomedical Sciences (PSIBS), University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK; School of Computer Science, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
authors.forename: Hamid
authors.initials: H
authors.lastname: Dehghani
keywords: (110.6955) Tomographic imaging; (120.4820) Optical systems; (170.1470) Blood or tissue constituent monitoring