title: A Tether Is a Tether Is a Tether: Tethering at Membrane Contact Sites.
abstract: Membrane contact sites enable interorganelle communication by positioning organelles in close proximity using molecular "tethers." With a growing understanding of the importance of contact sites, the hunt for new contact sites and their tethers is in full swing. Determining just what is a tether has proven challenging. Here, we aim to delineate guidelines that define the prerequisites for categorizing a protein as a tether. Setting this gold standard now, while groups from different disciplines are beginning to explore membrane contact sites, will enable efficient cooperation in the growing field and help to realize a great collaborative opportunity to boost its development.
authors.affiliation: Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel.
authors.forename: Michal
authors.initials: M
authors.lastname: Eisenberg-Bord
authors.affiliation: Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel.
authors.forename: Nadav
authors.initials: N
authors.lastname: Shai
authors.affiliation: Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel. Electronic address: maya.schuldiner@weizmann.ac.il.
authors.forename: Maya
authors.initials: M
authors.lastname: Schuldiner
authors.affiliation: Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel. Electronic address: maria.bohnert@weizmann.ac.il.
authors.forename: Maria
authors.initials: M
authors.lastname: Bohnert
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000378:metabolism*; D008561:Membrane Fusion; D009154:Mutation / Q000235:genetics; D025941:Protein Interaction Mapping; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D058615:Synthetic Biology
keywords: E-Syt; ERMES; NVJ; OSBP; VAP; contact site; lipid transfer protein; membrane fusion; molecular tether; vCLAMP