title: [Current status of warfarin therapy in Chinese patients with nonvalvular atrial fibrillation: a single center analysis].
abstract: Objective:To investigate the current status of warfarin therapy and the related factors in patients with nonvalvular atrial fibrillation(NVAF) based on data from a single center.Methods:We analyzed clinical data including baseline clinical characteristics, complications, concomitant medications and anti-thrombotic treatment in patients who were admitted to our hospital with NVAF from January 2014 to June 2014. The data were analyzed byttest, Chi-square test, fisher exact test and binary logistic regression analysis for the above indexes with warfarin utilization.Results:A total of 600 patients enrolled in this study, 560(93.3%) patients had a CHA2DS2-VASc score≥1, 162(28.9%) patients received warfarin (alone or in combination with antiplatelet agents), 244(43.6%) patients were treated with aspirin, 137(24.5%) patients did not receive anti-thrombotic treatment. Of the 600 patients, 172(28.7%) patients were treated in line with the current guideline recommendation, 266(44.3%) patients were treated improperly, 23(3.8%) patients were over-treated, 139(23.2%) patients received no anti-thrombotic treatment. Factors associated with anti-thrombotic treatment were persistent atrial fibrillation (OR=3.92, 95%CI1.43-10.78,P=0.008), radiofrequency ablation (OR=26.82, 95%CI7.03-102.38,P<0.001), the use of statins (OR=3.35, 95%CI1.30-8.63,P=0.012), anti-arrhythmic therapy (OR=3.42, 95%CI1.29-9.07,P=0.014), and aspirin (OR=0.02, 95%CI0-0.07,P<0.001).Conclusions:In this study, 428 (71.3%) NVAF patients were either un-treated, over-treated or inadequately treated. Intensive efforts are necessary to improve anti-thrombotic therapy status in NVAF population in China.
authors.affiliation: * Department of Pharmacy, People's Hospital of Henan Province, Zhengzhou 450003, China.
authors.forename: S J
authors.initials: SJ
authors.lastname: Zhao
authors.forename: H W
authors.initials: HW
authors.lastname: Zhao
authors.forename: X P
authors.initials: XP
authors.lastname: Wang
authors.forename: C Y
authors.initials: CY
authors.lastname: Gao
authors.forename: Y H
authors.initials: YH
authors.lastname: Qin
authors.forename: H X
authors.initials: HX
authors.lastname: Cai
authors.forename: B Y
authors.initials: BY
authors.lastname: Chen
authors.forename: J J
authors.initials: JJ
authors.lastname: Cao
mesh_terms: D000889:Anti-Arrhythmia Agents; D000925:Anticoagulants; D044466:Asian People; D001241:Aspirin; D001281:Atrial Fibrillation; D002681:China; D006760:Hospitalization; D006801:Humans; D010975:Platelet Aggregation Inhibitors; D014859:Warfarin
chemical_list: D000889:Anti-Arrhythmia Agents; D000925:Anticoagulants; D010975:Platelet Aggregation Inhibitors; D014859:Warfarin; D001241:Aspirin