title: Predictive factors and treatment outcome of laryngeal carcinoma recurrence.
abstract: Up to 30% of patients with laryngeal squamous cell carcinoma (SCC) present with recurrence after treatment. We analyzed factors associated with the risk of cancer recurrence and prognosis after recurrence.
  
  
  
  A nationwide laryngeal SCC cohort from Finnish university hospitals during 2001 to 2005 with initial successful therapy (n = 316) was analyzed.
  
  
  
  Laryngeal SCC recurred in 22% of patients. The median time to recurrence was 9 months, with 90% occurring within 36 months after treatment. The World Health Organization (WHO) performance status >0, neck metastasis at presentation, and nonsurgical treatment were independent prognostic factors for recurrence. Patients with local recurrence had a 5-year overall survival (OS) of 53% compared with 5% in patients with regional/distant recurrences. OS for glottic and nonglottic laryngeal SCC recurrence was 45% and 0%, respectively.
  
  
  
  The type of treatment affected the risk of recurrence in this retrospective series. Local recurrences carried a chance for successful salvage treatment. Routine follow-up beyond 36 months remains controversial. © 2016 Wiley Periodicals, Inc. Head Neck 39: 555-563, 2017.
authors.affiliation: Department of Otorhinolaryngology - Head and Neck Surgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
authors.forename: Aaro
authors.initials: A
authors.lastname: Haapaniemi
authors.affiliation: Department of Otorhinolaryngology - Head and Neck Surgery, Oulu University Hospital, Oulu, Finland.|PEDEGO Research Unit, University of Oulu, Oulu, Finland.|Medical Research Center Oulu, Oulu, Finland.
authors.forename: Janne
authors.initials: J
authors.lastname: Väisänen
authors.affiliation: Department of Otorhinolaryngology - Head and Neck Surgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
authors.forename: Timo
authors.initials: T
authors.lastname: Atula
authors.affiliation: Department of Otorhinolaryngology - Head and Neck Surgery, Oulu University Hospital, Oulu, Finland.|PEDEGO Research Unit, University of Oulu, Oulu, Finland.|Medical Research Center Oulu, Oulu, Finland.
authors.forename: Olli-Pekka
authors.initials: OP
authors.lastname: Alho
authors.affiliation: Department of Otorhinolaryngology - Head and Neck Surgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
authors.forename: Antti
authors.initials: A
authors.lastname: Mäkitie
authors.affiliation: Department of Otorhinolaryngology - Head and Neck Surgery, Oulu University Hospital, Oulu, Finland.|PEDEGO Research Unit, University of Oulu, Oulu, Finland.|Medical Research Center Oulu, Oulu, Finland.
authors.forename: Petri
authors.initials: P
authors.lastname: Koivunen
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000150:complications / Q000473:pathology / Q000628:therapy*; D059186:Chemoradiotherapy, Adjuvant / Q000379:methods; D015331:Cohort Studies; D016208:Databases, Factual; D005260:Female; D005387:Finland; D006785:Hospitals, University; D006801:Humans; D053208:Kaplan-Meier Estimate; D007822:Laryngeal Neoplasms / Q000150:complications / Q000473:pathology / Q000628:therapy*; D007825:Laryngectomy / Q000379:methods; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology* / Q000473:pathology / Q000628:therapy*; D010166:Palliative Care; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D018570:Risk Assessment; D016879:Salvage Therapy; D012737:Sex Factors; D016019:Survival Analysis; D016896:Treatment Outcome
keywords: laryngeal cancer; prognosis; radiotherapy; recurrence; surgery