title: Corynebacterium glutamicum for Sustainable Bioproduction: From Metabolic Physiology to Systems Metabolic Engineering.
abstract: Since its discovery 60 years ago, Corynebacterium glutamicum has evolved into a workhorse for industrial biotechnology. Traditionally well known for its remarkable capacity to produce amino acids, this Gram-positive soil bacterium, has become a flexible, efficient production platform for various bulk and fine chemicals, materials, and biofuels. The central turnstile of all these achievements is our excellent understanding of its metabolism and physiology. This knowledge base, together with innovative systems metabolic engineering concepts, which integrate systems and synthetic biology into strain engineering, has upgraded C. glutamicum into one of the most successful industrial microorganisms in the world.
authors.affiliation: Institute of Systems Biotechnology, Saarland University, 66123, Saarbrücken, Germany.
authors.forename: Judith
authors.initials: J
authors.lastname: Becker
authors.affiliation: Institute of Systems Biotechnology, Saarland University, 66123, Saarbrücken, Germany.
authors.forename: Gideon
authors.initials: G
authors.lastname: Gießelmann
authors.affiliation: Institute of Systems Biotechnology, Saarland University, 66123, Saarbrücken, Germany.
authors.forename: Sarah Lisa
authors.initials: SL
authors.lastname: Hoffmann
authors.affiliation: Institute of Systems Biotechnology, Saarland University, 66123, Saarbrücken, Germany. christoph.wittmann@uni-saarland.de.
authors.forename: Christoph
authors.initials: C
authors.lastname: Wittmann
mesh_terms: D048230:Corynebacterium glutamicum / Q000502:physiology*; D060847:Metabolic Engineering / Q000379:methods*; D049490:Systems Biology / Q000379:methods*
keywords: Diaminopentane; Industrial biotechnology; Industrial raw material; Lysine; Metabolic network; Pathway engineering; Rational design