title: Crystalline nephropathy caused by tosufloxacin.
abstract: A 14-year-old girl was treated for 3 days with tosufloxacin (450 mg twice a day) for acute bronchitis and then developed acute kidney injury. Renal ultrasound showed enlarged kidneys without hydronephrosis. Urinalysis indicated drug crystal casts (2-3/HPF), consistent with drug-induced crystalline nephropathy. The patient recovered gradually with i.v. hydration and discontinuation of tosufloxacin, leading to the diagnosis of tosufloxacin crystalline nephropathy. Medical practitioners should be aware that crystalline nephropathy can occur in pediatric patients receiving tosufloxacin.
authors.affiliation: Department of Pediatrics, Seirei-Mikatahara General Hospital, Hamamatsu, Shizuoka, Japan.
authors.forename: Risa
authors.initials: R
authors.lastname: Matsubara
authors.affiliation: Department of Pediatrics, Seirei-Mikatahara General Hospital, Hamamatsu, Shizuoka, Japan.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Kibe
authors.affiliation: Department of Pediatrics, Seirei-Mikatahara General Hospital, Hamamatsu, Shizuoka, Japan.
authors.forename: Takemasa
authors.initials: T
authors.lastname: Nomura
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced*; D000293:Adolescent; D001706:Biopsy; D001991:Bronchitis / Q000188:drug therapy; D003937:Diagnosis, Differential; D005260:Female; D024841:Fluoroquinolones / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000473:pathology*; D009287:Naphthyridines / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D024841:Fluoroquinolones; D009287:Naphthyridines; C055185:tosufloxacin
keywords: acute kidney injury; crystalline nephropathy; crystalluria; tosufloxacin