title: A Novel Protein C Mutation Causing Neonatal Purpura Fulminans.
abstract: BACKGROUND
  Neonatal purpura fulminans due to congenital protein C deficiency is a rare disorder.
  
  
  METHODS
  A four-day-old neonate presented with multiple necrotic skin lesions with abnormal coagulation profile.
  
  
  RESULTS
  Skin lesions responded to repeated plasma transfusions but the neonate developed bilateral retinal detachment. A novel homozygous PROC gene mutation was noted in the neonate.
  
  
  CONCLUSIONS
  Molecular diagnosis and prenatal counseling in neonatal purpura fulminans are vital considering the poor outcome.
authors.affiliation: Department of Neonatology, Institute of child health and hospital for children, Egmore, Chennai, India. Correspondence to: Dr Mangala Bharathi S, Department of Neonatology, Institute of child health and hospital for children, Egmore, Chennai-600008, India. drmangalabharathi@gmail.com.
authors.forename: Usha
authors.initials: U
authors.lastname: Devi R
authors.forename: Mangala
authors.initials: M
authors.lastname: Bharathi S
authors.forename: Nikesh
authors.initials: N
authors.lastname: Kawankar
mesh_terms: D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009154:Mutation / Q000235:genetics; D009336:Necrosis / Q000473:pathology; D011486:Protein C / Q000235:genetics*; D020151:Protein C Deficiency; D055665:Purpura Fulminans; D013848:Thigh / Q000473:pathology
chemical_list: D011486:Protein C