title: A Pilot Study Using Intratympanic Methylprednisolone for Treatment of Persistent Posterior Canal Benign Paroxysmal Positional Vertigo.
abstract: OBJECTIVE
  To assess the effect of intratympanic methylprednisolone (ITMP) in posterior canal benign paroxysmal positional vertigo (BPPV) that fails treatment involving repositioning maneuver in a case series.
  
  
  METHODS
  Nine patients with persistent posterior canal BPPV after 6 or more repositioning maneuvers were treated by ITMP (two weekly doses of 0.3-0.4 mL at 40 mg/mL) before repeating the repositioning procedures.
  
  
  RESULTS
  Following ITMP treatment, 7 out of 9 patients were relieved of their symptoms and did not exhibit positional nystagmus after 1 or 2 repositioning maneuvers. The number of positional maneuvers performed before and after ITMP treatment in these 7 patients showed a statistically significant (p=0.016) reduction in the amount of repositioning treatments required. None of the 7 respondent patients showed any relapses during the follow-up period (follow-up range: 11-95 months).
  
  
  CONCLUSIONS
  Administering ITMP before resuming repositioning procedures can be a useful treatment for persistent BPPV of the posterior canal.
authors.affiliation: Department of Otorhinolaryngology, Hospital de Cabueñes, Gijón, Spain. paz.perez@sespa.es.
authors.forename: Paz
authors.initials: P
authors.lastname: Pérez
authors.forename: Virginia
authors.initials: V
authors.lastname: Franco
authors.forename: Manuel
authors.initials: M
authors.lastname: Oliva
authors.forename: José A
authors.initials: JA
authors.lastname: López Escámez
mesh_terms: D000368:Aged; D065635:Benign Paroxysmal Positional Vertigo / Q000188:drug therapy*; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D000069555:Injection, Intratympanic; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use*; D008875:Middle Aged; D056888:Patient Positioning; D010865:Pilot Projects; D011446:Prospective Studies; D014724:Vestibular Function Tests
chemical_list: D005938:Glucocorticoids; D008775:Methylprednisolone