title: The Effects of the New Methodology Application on the Method of Pricing of Drugs-The Case of the Republic of Macedonia.
abstract: BACKGROUND
  The introduction of a new methodology for the pricing of drugs by the Agency of Medicines of the Republic of Macedonia for the period 2012 to 2015 resulted in a price reduction of 1386 drugs.
  
  
  OBJECTIVE
  This pioneer study evaluated the effects of the price changes during this period of 4 years and the consequent effects on the sale quantities for the segmented Anatomical Therapeutic Chemical groups.
  
  
  METHODS
  The drugs were grouped by the size of the reductions, by segmenting the drugs by generic names, and by the Anatomical Therapeutic Chemical classification, in which the quantities are grouped by generic names and the prices are calculated by average values for a period of 1 year.
  
  
  RESULTS
  Analysis of the relations between price changes and quantities sold showed that since the introduction of the new methodology the decrease in the prices pushed down the sales of the drugs.
  
  
  CONCLUSIONS
  This article presents not only the market developments but also projects the tendencies, concluding clearly that focusing only on the price reduction of drugs and not on the implementation of the pharmacoeconomic studies is deviating the supply of drugs that are on the market and affecting their quality. The trends indicate that patients are using old-generation drugs, packaging forms that do not fully answer the market demand, and policies that significantly affect the suppliers. The presented analysis confirms that if the new methodology is only partially implemented and is not followed in full consideration of the pharmacoeconomic studies, negative consequences will also have an impact on regional pharmaceutical markets, which are benchmarking prices of drugs with the Macedonian market.
authors.affiliation: Faculty of Pharmacy, University "Ss. Cyril and Methodius," Skopje, Republic of Macedonia. Electronic address: rubin@trust.com.mk.
authors.forename: Rubin
authors.initials: R
authors.lastname: Zareski
authors.affiliation: Faculty of Pharmacy, University "Ss. Cyril and Methodius," Skopje, Republic of Macedonia.
authors.forename: A
authors.initials: A
authors.lastname: Kapedanovska Nestorovska
authors.affiliation: Faculty of Pharmacy, University "Ss. Cyril and Methodius," Skopje, Republic of Macedonia.
authors.forename: A
authors.initials: A
authors.lastname: Grozdanova
authors.affiliation: Agency of Medicines of the Republic of Macedonia (MALMED), Republic of Macedonia.
authors.forename: B
authors.initials: B
authors.lastname: Dimitrova
authors.affiliation: Faculty of Pharmacy, University "Ss. Cyril and Methodius," Skopje, Republic of Macedonia.
authors.forename: L J
authors.initials: LJ
authors.lastname: Suturkova
authors.affiliation: Faculty of Pharmacy, University "Ss. Cyril and Methodius," Skopje, Republic of Macedonia.
authors.forename: Z
authors.initials: Z
authors.lastname: Sterjev
mesh_terms: D003132:Commerce; D003363:Cost Control; D003365:Costs and Cost Analysis; D016527:Drug Costs; D004345:Drug Industry; D016568:Drugs, Generic / Q000191:economics*; D004465:Economic Competition; D017850:Economics, Pharmaceutical; D005060:Europe; D006801:Humans
chemical_list: D016568:Drugs, Generic
keywords: market correlation; pricing methodology; reference pricing; regulation