title: Impact of clinical syndrome-wise categorisation of antimicrobial susceptibility profiles on nosocomial isolates in a tertiary care hospital in Delhi, India.
abstract: The objective of this study was to investigate the impact of clinical syndrome-wise categorisation of antimicrobials on the antibiotic susceptibility of nosocomial bacteria at a tertiary care hospital in Delhi, India. The susceptibility of 226 nosocomial bacterial isolates collected during 2008-2011 to meropenem, piperacillin/tazobactam, cefepime, tigecycline, amoxicillin/clavulanic acid (AMC), amikacin, ceftriaxone and ciprofloxacin was monitored and was compared with the antibiotic susceptibility profiles of 72 isolates collected during 2002-2007. During 2008-2011, the isolates included 85% Gram-negative isolates and 15% meticillin-sensitive staphylococci. There was no difference in the susceptibility of the isolates between 2002 and 2007 and 2008-2011, except for a significant increase in Escherichia coli isolates susceptible to AMC (from 73% to 100%), amikacin (70-100%) and cefepime (22-86%), in Klebsiella isolates susceptible to ciprofloxacin (from 25% to 80%) and cefepime (45-75%) and in Pseudomonas isolates susceptible to AMC (from 25% to 86%). In conclusion, during the past decade a clinical syndrome-wise categorisation of antimicrobials in frequent usage as well as culture-based categorisation of infections into nosocomial/community-acquired was useful in establishing the generally insignificant change in the susceptibility of nosocomial isolates and an upsurge in the susceptibility of some isolates to a few antimicrobials. Regular updates on drifts in the antimicrobial susceptibility of local isolates and surveillance of nosocomial infections would be valuable for tackling the emergence of antibiotic-resistant bacteria.
authors.affiliation: Sant Parmanand Hospital, 18 Alipore Road, Delhi 110054, India. Electronic address: subhashbhapaji@gmail.com.
authors.forename: Subhash C
authors.initials: SC
authors.lastname: Arya
authors.affiliation: Sant Parmanand Hospital, 18 Alipore Road, Delhi 110054, India.
authors.forename: Nirmala
authors.initials: N
authors.lastname: Agarwal
authors.affiliation: Sant Parmanand Hospital, 18 Alipore Road, Delhi 110054, India.
authors.forename: Shekhar
authors.initials: S
authors.lastname: Agarwal
authors.affiliation: Sant Parmanand Hospital, 18 Alipore Road, Delhi 110054, India.
authors.forename: Kamini
authors.initials: K
authors.lastname: Singh
authors.affiliation: Sant Parmanand Hospital, 18 Alipore Road, Delhi 110054, India.
authors.forename: Dolly
authors.initials: D
authors.lastname: Wadhwa
keywords: Antimicrobial susceptibility; Clinical syndromes; Multidrug-resistant bacteria; Nosocomial infection