title: Effects of CCK-8 and Cystathionine γ-Lyase/Hydrogen Sulfide System on Acute Lung Injury in Rats.
abstract: Acute lung injury (ALI) is mainly characterized by diffusive injuries to lung epithelium and increased permeability of alveolar-capillary membranes caused by various factors, which leads to pulmonary edema and pulmonary closure. Lipopolysaccharide (LPS), which is the main component of the cell wall of gram-negative bacteria, is one of the most important factors causing pulmonary infection and ALI. More and more reports have indicated that hydrogen sulfide (H2S) is closely correlated with ALI and has anti-inflammation function, while the specific mechanism needs further investigation. Cholecystokinin-octapeptide (CCK-8), which is an important endogenous functional fragment belonging to CCK family, participates in anti-inflammatory and anti-endotoxic shock (ES). Whether CCK-8 plays important roles in curing ALI also needs further investigation. Herein, we concluded that CCK-8 alleviated the ALI induced by LPS via regulating the catalytic activity of cystathionine γ-lyase (CSE) and the formation of H2S. This work provides new medicine-designed target for clinical doctor to prevent and cure ALI.
authors.affiliation: No. 2 Department of Respiratory, The Third Hospital of Hebei Medical University, Hebei, People's Republic of China.
authors.forename: Fengjun
authors.initials: F
authors.lastname: Tian
authors.affiliation: Department of Pathophysiology, Hebei Medical University, Hebei, People's Republic of China.
authors.forename: Yiling
authors.initials: Y
authors.lastname: Ling
authors.affiliation: No. 2 Department of Respiratory, The Third Hospital of Hebei Medical University, Hebei, People's Republic of China.
authors.forename: Yuqin
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Critical Care Medicine, The Third Hospital of Hebei Medical University, No. 139 Ziqiang Road, Qiaoxi District, Shijazhuang, Hebei, 050051, China. Wzyphd@126.com.
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Wang
mesh_terms: D055371:Acute Lung Injury / Q000188:drug therapy* / Q000209:etiology; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D003542:Cystathionine gamma-Lyase / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D006862:Hydrogen Sulfide / Q000494:pharmacology*; D007249:Inflammation / Q000188:drug therapy; D008070:Lipopolysaccharides / Q000494:pharmacology; D051381:Rats; D012772:Shock, Septic / Q000188:drug therapy; D012844:Sincalide / Q000502:physiology*
chemical_list: D000893:Anti-Inflammatory Agents; D008070:Lipopolysaccharides; D003542:Cystathionine gamma-Lyase; D012844:Sincalide; D006862:Hydrogen Sulfide
keywords: acute lung injury (ALI); cholecystokinin-octapeptide (CCK-8); cystathionine γ-lyase (CSE); hydrogen sulfide (H2S); lipopolysaccharide (LPS)