title: Allergy immunotherapy across the life cycle to promote active and healthy ageing: from research to policies: An AIRWAYS Integrated Care Pathways (ICPs) programme item (Action Plan B3 of the European Innovation Partnership on active and healthy ageing) and the Global Alliance against Chronic Respiratory Diseases (GARD), a World Health Organization GARD research demonstration project.
abstract: Allergic diseases often occur early in life and persist throughout life. This life-course perspective should be considered in allergen immunotherapy. In particular it is essential to understand whether this al treatment may be used in old age adults. The current paper was developed by a working group of AIRWAYS integrated care pathways for airways diseases, the model of chronic respiratory diseases of the European Innovation Partnership on active and healthy ageing (DG CONNECT and DG Santé). It considered (1) the political background, (2) the rationale for allergen immunotherapy across the life cycle, (3) the unmet needs for the treatment, in particular in preschool children and old age adults, (4) the strategic framework and the practical approach to synergize current initiatives in allergen immunotherapy, its mechanisms and the concept of active and healthy ageing.
authors.affiliation: National Heart and Lung Institute, Royal Brompton Hospital NHS, Imperial College London, London, UK.
authors.forename: M A
authors.initials: MA
authors.lastname: Calderon
authors.affiliation: Unité d'allergologie, Département de Pneumologie et AddictologieHôpital Arnaud de Villeneuve, CHRU de Montpellier, Sorbonne Universités, UPMC Paris 06, UMR-S 1136, IPLESP, Equipe EPAR, 75013 Paris, France.
authors.forename: P
authors.initials: P
authors.lastname: Demoly
authors.affiliation: University of South Florida Morsani College of Medicine, Tampa, FL USA.
authors.forename: T
authors.initials: T
authors.lastname: Casale
authors.affiliation: Christine Kühne Center for Allergy Research and Education (CK-CARE), Swiss Institute of Allergy and Asthma Research (SIAF)University of Zurich, Davos, Switzerland.
authors.forename: C A
authors.initials: CA
authors.lastname: Akdis
authors.affiliation: Upper Airways Research Laboratory (URL), ENT Department, University Hospital Ghent, Ghent, Belgium.
authors.forename: C
authors.initials: C
authors.lastname: Bachert
authors.affiliation: iQ4U consultants Ltd, London, UK.
authors.forename: M
authors.initials: M
authors.lastname: Bewick
authors.affiliation: Allergy Unit, Department of Internal Medicine, University Hosp Ospedali Riuniti, Ancona, Italy.
authors.forename: B M
authors.initials: BM
authors.lastname: Bilò
authors.affiliation: Department of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
authors.forename: B
authors.initials: B
authors.lastname: Bohle
authors.affiliation: Second University of Naples and IFT-CNR, Rome, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Bonini
authors.affiliation: National Heart and Lung Institute, Royal Brompton Hospital NHS, Imperial College London, London, UK.
authors.forename: A
authors.initials: A
authors.lastname: Bush
authors.affiliation: Unité d'allergologie, Département de Pneumologie et AddictologieHôpital Arnaud de Villeneuve, CHRU de Montpellier, Sorbonne Universités, UPMC Paris 06, UMR-S 1136, IPLESP, Equipe EPAR, 75013 Paris, France.
authors.forename: D P
authors.initials: DP
authors.lastname: Caimmi
authors.affiliation: Allergy and Respiratory Diseases Clinic, DIMI, University of Genoa, IRCCS AOU San Martino-IST, Genoa, Italy.
authors.forename: G W
authors.initials: GW
authors.lastname: Canonica
authors.affiliation: Allergy Section, Department of Internal Medicine, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
authors.forename: V
authors.initials: V
authors.lastname: Cardona
authors.affiliation: Division of Allergy, Hôpital Arnaud de Villeneuve, Department of Pulmonology, University Hospital of Montpellier, Montpellier - UPMC Univ Paris 06, UMRS 1136, Equipe - EPAR - IPLESP, Sorbonne Universités, Paris, France.
authors.forename: A M
authors.initials: AM
authors.lastname: Chiriac
authors.affiliation: Nova Southeastern University, Ft. Lauderdale, FL USA.
authors.forename: L
authors.initials: L
authors.lastname: Cox
authors.affiliation: National Heart and Lung Institute, Royal Brompton Hospital NHS, Imperial College London, London, UK.
authors.forename: A
authors.initials: A
authors.lastname: Custovic
authors.affiliation: Allergy Division, Chest Disease Department, University Hospital of Strasbourg, Strasbourg, France.
authors.forename: F
authors.initials: F
authors.lastname: De Blay
authors.affiliation: University Versailles Saint-Quentin and Clinical Pharmacology Unit, UPRES EA 220, Department of Airway Diseases, Foch Hospital, Suresnes, France.
authors.forename: P
authors.initials: P
authors.lastname: Devillier
authors.affiliation: Respiratory Diseases Department, Rangueil-Larrey Hospital, Toulouse, France.
authors.forename: A
authors.initials: A
authors.lastname: Didier
authors.affiliation: Dipartimento BioMedico di Medicina Interna e Specialistica (Di.Bi.M.I.S), University of Palermo, Palermo, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Di Lorenzo
authors.affiliation: Guy's and St. Thomas' NHS Trust, Kings College, London, UK.
authors.forename: G
authors.initials: G
authors.lastname: Du Toit
authors.affiliation: Allergy and Clinical Immunology Section, National Heart and Lung Institute, Imperial College London, London, UK.
authors.forename: S R
authors.initials: SR
authors.lastname: Durham
authors.affiliation: Department of Pediatric Pulmonology and Allergy, Children's Hospital, Aarau, Switzerland.
authors.forename: P
authors.initials: P
authors.lastname: Eng
authors.affiliation: Division of Allergy, Department of Pediatrics, Bambino Gesù Pediatric Hospital, Vatican City, Rome, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Fiocchi
authors.affiliation: King's College London Allergy Academy, London, UK.
authors.forename: A T
authors.initials: AT
authors.lastname: Fox
authors.affiliation: Section of Allergology, Department of Internal Medicine, Erasmus Medical Center, Building Rochussenstraat, Rotterdam, The Netherlands.
authors.forename: R Gerth
authors.initials: RG
authors.lastname: van Wijk
authors.affiliation: Unidad Alergia and Asma, Hospital San Bernardo, Salta, Argentina.
authors.forename: R M
authors.initials: RM
authors.lastname: Gomez
authors.affiliation: Skin and Allergy Hospital, Helsinki University Hospital, Helsinki, Finland.
authors.forename: T
authors.initials: T
authors.lastname: Haathela
authors.affiliation: Hans Christian Andersen Children's Hospital, Odense University Hospital, Odense, Denmark.
authors.forename: S
authors.initials: S
authors.lastname: Halken
authors.affiliation: Clinical Department of Otorhinolaryngology, Head and Neck Surgery, University Hospitals Leuven, KU Leuven, Louvain, Belgium.
authors.forename: P W
authors.initials: PW
authors.lastname: Hellings
authors.affiliation: Allergy Learning and Consulting, Secretary Immunotherapy Interest Group EAACI, Copenhagen, Denmark.
authors.forename: L
authors.initials: L
authors.lastname: Jacobsen
authors.affiliation: Allergology Department, Centre de l'Asthme et des Allergies, Hôpital d'Enfants Armand-Trousseau, INSERM, UMR_S 1136, Sorbonne Universités, UPMC Univ Paris, Institut Pierre Louis d'Epidémiologie et de Santé Publique, Equipe EPAR, Paris, France.
authors.forename: J
authors.initials: J
authors.lastname: Just
authors.affiliation: Hospital Sírio Libanês, São Paulo, Brazil ; University Hospital of Montpellier, Montpellier, France ; UPMC Paris 06, UMR-S 1136, IPLESP, Equipe EPAR, Sorbonne Universités, Paris, France.
authors.forename: L K
authors.initials: LK
authors.lastname: Tanno
authors.affiliation: Allergy and Asthma Center Westend, Outpatient Clinic and Clinical Research Center, Ackermann, Hanf, & Kleine-Tebbe, Berlin, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Kleine-Tebbe
authors.affiliation: Center for Rhinology and Allergology, German Society for Otorhinolaryngology HNS, Wiesbaden, Germany.
authors.forename: L
authors.initials: L
authors.lastname: Klimek
authors.affiliation: Departments of Immunology and Dermatology/Allergology, University Medical Center Utrecht, Heidelberglaan, Utrecht, The Netherlands.
authors.forename: E F
authors.initials: EF
authors.lastname: Knol
authors.affiliation: Medical University of Lodz, Lodz, Poland.
authors.forename: P
authors.initials: P
authors.lastname: Kuna
authors.affiliation: ARIA, Mexico, DF Mexico ; AAAAI, Hospital Médica Sur, Mexico, DF Mexico.
authors.forename: D E
authors.initials: DE
authors.lastname: Larenas-Linnemann
authors.affiliation: Research Centre for Prevention and Health, The Capital Region of Denmark, Copenhagen, Denmark ; Department of Clinical Experimental Research, Rigshospitalet, Copenhagen, Denmark ; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
authors.forename: A
authors.initials: A
authors.lastname: Linneberg
authors.affiliation: Pediatric Pneumology and Immunology, Charité Medical University, Berlin, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Matricardi
authors.affiliation: Danish Allergy Centre, Allergy Clinic, Gentofte University Hospital, Hellerup, Denmark.
authors.forename: H J
authors.initials: HJ
authors.lastname: Malling
authors.affiliation: IMSIE, Klinikum der Universität zu Köln A. ö. R., Cologne, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Moesges
authors.affiliation: Unitat de Rinologia i Clínica de l'Olfacte, ENT Department, Hospital Clínic, Clinical and Experimental Respiratory Immunoallergy, IDIBAPS, CIBERES, Barcelona, Catalonia Spain.
authors.forename: J
authors.initials: J
authors.lastname: Mullol
authors.affiliation: Department of Women and Child Health, Food Allergy Referral Centre Veneto Region, Padua General University Hospital, Padua, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Muraro
authors.affiliation: Allergy Unit, 2nd Pediatric Clinic, University of Athens, Athens, Greece.
authors.forename: N
authors.initials: N
authors.lastname: Papadopoulos
authors.affiliation: Allergy and Respiratory Diseases, IRCCS San Martino-IST, Univesity of Genoa, Genoa, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Passalacqua
authors.affiliation: ASST Grande Ospedale Metropolitano Niguarda, P.zza Ospedale Maggiore, Milan, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Pastorello
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, Universitätsmedizin Mannheim, Mannheim, Germany ; Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany ; Center for Rhinology and Allergology, Wiesbaden, Germany.
authors.forename: O
authors.initials: O
authors.lastname: Pfaar
authors.affiliation: Division of Applied Health Sciences, Primary Care Respiratory Medicine, Academic Primary Care, University of Aberdeen, Aberdeen, Scotland, UK ; Research in Real Life (RiRL), Oakington, Cambridge, UK ; Optimum Patient Care Ltd, Singapore, Singapore.
authors.forename: D
authors.initials: D
authors.lastname: Price
authors.affiliation: Allergy Section, Hospital Infantil Universitario Niño Jesús, Madrid, Spain.
authors.forename: P Rodriguez
authors.initials: PR
authors.lastname: Del Rio
authors.affiliation: Department of Dermatology and Allergology, Ludwig-Maximillian University, Munich, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Ruëff
authors.affiliation: Department of Prevention of Environmental Hazards and Allergology, Medical University of Warsaw, Warsaw, Poland.
authors.forename: B
authors.initials: B
authors.lastname: Samolinski
authors.affiliation: Royal National Throat, Nose and Ear Hospital, London, UK ; University College London, London, UK.
authors.forename: G K
authors.initials: GK
authors.lastname: Scadding
authors.affiliation: Clinical Trials Center, University Hospital of Zurich, Zurich, Switzerland.
authors.forename: G
authors.initials: G
authors.lastname: Senti
authors.affiliation: Immunomodulation and Tolerance Group, Allergy and Clinical Immunology, Inflammation, Repair and Development Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London, UK ; MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, London, UK.
authors.forename: M H
authors.initials: MH
authors.lastname: Shamji
authors.affiliation: Asthma UK Centre for Applied Research, Centre for Medical Informatics, Usher Institute of Population Health Sciences and Informatics, The University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG UK.
authors.forename: A
authors.initials: A
authors.lastname: Sheikh
authors.affiliation: SLAAI, Asuncion, Paraguay.
authors.forename: J C
authors.initials: JC
authors.lastname: Sisul
authors.affiliation: Programa de Pòs-Graduação em Pediatria e Ciências Aplicadas à Pediatria, Departamento de Pediatria EPM, UNIFESP, São Paulo, Brazil.
authors.forename: D
authors.initials: D
authors.lastname: Sole
authors.affiliation: Department of Dermatology and Venerology, Medical University of Graz, Graz, Austria ; Allergy Outpatient Clinic Reumannplatz, Vienna, Austria.
authors.forename: G J
authors.initials: GJ
authors.lastname: Sturm
authors.affiliation: Servicio de Alergologia, Complejo Hospitalario de Navarra, Pamplona, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Tabar
authors.affiliation: Departments of Experimental Immunology and Otorhinolaryngology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
authors.forename: R
authors.initials: R
authors.lastname: Van Ree
authors.affiliation: Unit of Geriatric Immunoallergology, Interdisciplinary Department of Medicine, University of Bari Medical School, Bari, Italy.
authors.forename: M T
authors.initials: MT
authors.lastname: Ventura
authors.affiliation: Allergy Department, Complejo Hospitalario Universitario de Santiago de Compostela, Santiago de Compostela, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Vidal
authors.affiliation: Respiratory and Allergic Disease Division, Department of Paediatrics, Medical University of Graz, Graz, Austria.
authors.forename: E M
authors.initials: EM
authors.lastname: Varga
authors.affiliation: Allergie-Centrum-Charité, Klinik für Dermatologie, Venerologie und Allergologie, Charité-Universitätsmedizin Berlin, Berlin, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Worm
authors.affiliation: Allergie-Centrum-Charité, Klinik für Dermatologie, Venerologie und Allergologie, Charité-Universitätsmedizin Berlin, Berlin, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Zuberbier
authors.affiliation: University Hospital of Montpellier, Montpellier, France ; Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon, European Innovation Partnership on Active and Healthy Ageing Reference Site, Paris, France ; INSERM, VIMA, U1168, Ageing and Chronic Diseases, Epidemiological and Public Health Approaches, Paris, France ; UVSQ, UMR-S 1168, Université Versailles St-Quentin-en-Yvelines, Versailles Cedex, France ; CHRU, 371 Avenue du Doyen Gaston Giraud, 34295 Montpellier Cedex 5, France.
authors.forename: J
authors.initials: J
authors.lastname: Bousquet
keywords: AIRWAYS ICPs; Ageing; Allergen immunotherapy; Asthma; EIP on AHA; Rhinitis