title: Correlation of Glut-1 and Glut-3 expression with F-18 FDG uptake in pulmonary inflammatory lesions.
abstract: The aim of the study was to investigate the correlation of glucose transporter-1 (Glut-1) and glucose transporter-3 (Glut-3) expression with F-18 FDG uptake in pulmonary inflammatory lesions.Twenty-two patients with pulmonary inflammatory lesions underwent positron emission tomography/computed tomography (PET/CT) examination preoperatively, and Glut-1 and Glut-3 expression were detected by immunohistochemistry in these lesions. Correlations of Glut-1 and Glut-3 with F-FDG uptake were assessed using Spearman's rank correlation test.The maximum standardized uptake value (SUVmax) of pulmonary inflammatory lesions in 22 patients was 0.50 to 7.50, with a mean value of 3.66 ± 1.62. Immunohistochemical staining scores of Glut-1 and Glut-3 were 2.18 ± 0.96 and 2.82 ± 1.37, respectively. The expression of Glut-1 and Glut-3 was positively correlated with F-18 FDG uptake. Glut-3 expression was evidently higher than Glut-1 expression in 22 patients.Glut-1 and Glut-3 expressions are high in pulmonary inflammatory lesions, and Glut-3 plays a more important role in F-18 FDG uptake in pulmonary inflammatory lesions.
authors.affiliation: Nuclear Medicine Department, The Affiliated Hospital of Qingdao University, Qingdao Nuclear Medicine Department, Cangzhou Central Hospital, Hebei province, China.
authors.forename: Zhen Guang
authors.initials: ZG
authors.lastname: Wang
authors.forename: Ming Ming
authors.initials: MM
authors.lastname: Yu
authors.forename: Yu
authors.initials: Y
authors.lastname: Han
authors.forename: Feng Yu
authors.initials: FY
authors.lastname: Wu
authors.forename: Guang Jie
authors.initials: GJ
authors.lastname: Yang
authors.forename: Da Cheng
authors.initials: DC
authors.lastname: Li
authors.forename: Si Min
authors.initials: SM
authors.lastname: Liu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics*; D051272:Glucose Transporter Type 1 / Q000378:metabolism*; D051274:Glucose Transporter Type 3 / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D007249:Inflammation / Q000000981:diagnostic imaging / Q000378:metabolism; D008171:Lung Diseases / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D000072078:Positron Emission Tomography Computed Tomography; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics*
chemical_list: D051272:Glucose Transporter Type 1; D051274:Glucose Transporter Type 3; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18