title: Embryos cultured in a time-lapse system result in superior treatment outcomes: a strict matched pair analysis.
abstract: A retrospective strict matched-pair analysis of 728 treatment cycles between January 2011 and September 2014 was performed. A total of 364 treatment cycles, where all embryos were cultured and examined in EmbryoScope®, were matched to treatment cycles where all the embryos were cultured in a standard incubator with conventional morphological examination. Matching was performed for patient age, number of oocytes collected, treatment type and date of oocyte collection (± six months). The clinical (CPR), implantation (IR), live birth (LBR) and miscarriage rates (MR) were calculated and considered significant when p < 0.05 (Chi-square test). CPR, IR and LBR were found to be significantly higher in the time-lapse system (TLS) group compared to the standard incubation group (CPR = 44.8% versus 36.5%, p = 0.02; IR = 39.3% versus 32.2%, p = 0.03; and LBR = 43.1% versus 33.8%, p = 0.01). Although there was a 5.5% decrease in the MR for the TLS group when compared to the standard incubation group, this result was not statistically significant (18.9% versus 24.4%, p = 0.19). There is a paucity of well-designed studies to confirm that embryos cultured and examined in TLS can result in superior treatment outcomes, and this strict-matched pair analysis with a large cohort of treatment cycles indicates the advantage of using TLS.
authors.affiliation: a The Hewitt Fertility Centre , Liverpool Women's NHS Foundation Trust , Liverpool , UK.
authors.forename: Amy
authors.initials: A
authors.lastname: Barrie
authors.affiliation: a The Hewitt Fertility Centre , Liverpool Women's NHS Foundation Trust , Liverpool , UK.
authors.forename: Roy
authors.initials: R
authors.lastname: Homburg
authors.affiliation: b Centre for Biomedicine and School of Healthcare Science, Manchester Metropolitan University , Manchester , UK.
authors.forename: Garry
authors.initials: G
authors.lastname: McDowell
authors.affiliation: c Postgraduate Medical Institute, Faculty of Health and Social Care, Edge Hill University , Ormskirk , UK.
authors.forename: Jeremy
authors.initials: J
authors.lastname: Brown
authors.affiliation: a The Hewitt Fertility Centre , Liverpool Women's NHS Foundation Trust , Liverpool , UK.
authors.forename: Charles
authors.initials: C
authors.lastname: Kingsland
authors.affiliation: a The Hewitt Fertility Centre , Liverpool Women's NHS Foundation Trust , Liverpool , UK.
authors.forename: Stephen
authors.initials: S
authors.lastname: Troup
mesh_terms: D000022:Abortion, Spontaneous; D046149:Embryo Culture Techniques / Q000379:methods*; D010064:Embryo Implantation; D004624:Embryo Transfer; D047108:Embryonic Development; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D050498:Live Birth; D016555:Matched-Pair Analysis; D054315:Oocyte Retrieval; D011247:Pregnancy; D011256:Pregnancy Outcome; D018873:Pregnancy Rate; D012189:Retrospective Studies; D059008:Time-Lapse Imaging
keywords: EmbryoScope; IVF; matched-pair; time-lapse