title: Post-transplant lymphoproliferative disorder presenting with skin ulceration in a renal transplant recipient who achieved sustained remission with rituximab therapy: A case report.
abstract: Post-transplant lymphoproliferative disorder (PTLD) is associated with a variety of clinical presentations, but rarely involves the skin. We herein report a case of PTLD presenting with skin ulceration in a renal transplant recipient. A biopsy of the ulcer confirmed the diagnosis of diffuse large B-cell lymphoma. The patient was initially treated with immunosuppression reduction, but the skin ulcer persisted. He was then treated with two courses of chemotherapy, but his condition was complicated with cryptococcal infection. Antifungal agents were administered to control the fungal infection. The patient later developed lymphoma recurrence and was successfully treated with single-agent rituximab. The patient remains well 6 years after treatment, with no evidence of disease relapse. Therefore, PTLD may manifest as skin lesions and physicians must be aware of this rare presentation.
authors.affiliation: Department of Medicine, Tuen Mun Hospital, Hong Kong SAR 999077, P.R. China; Department of Medicine and Therapeutics, Prince of Wales Hospital, Hong Kong SAR 999077, P.R. China.
authors.forename: Man Fai
authors.initials: MF
authors.lastname: Law
authors.affiliation: Department of Medicine, Tuen Mun Hospital, Hong Kong SAR 999077, P.R. China.
authors.forename: Hay Nun
authors.initials: HN
authors.lastname: Chan
authors.affiliation: Department of Medicine, Tuen Mun Hospital, Hong Kong SAR 999077, P.R. China.
authors.forename: Ho Kei
authors.initials: HK
authors.lastname: Lai
authors.affiliation: Department of Medicine, Tuen Mun Hospital, Hong Kong SAR 999077, P.R. China.
authors.forename: Chung Yin
authors.initials: CY
authors.lastname: Ha
authors.affiliation: Department of Medicine, Tuen Mun Hospital, Hong Kong SAR 999077, P.R. China.
authors.forename: Celia
authors.initials: C
authors.lastname: Ng
authors.affiliation: Department of Medicine, Tuen Mun Hospital, Hong Kong SAR 999077, P.R. China.
authors.forename: Yiu Ming
authors.initials: YM
authors.lastname: Yeung
authors.affiliation: Department of Medicine, Tuen Mun Hospital, Hong Kong SAR 999077, P.R. China.
authors.forename: Sze Fai
authors.initials: SF
authors.lastname: Yip
keywords: post-transplant lymphoproliferative disorder; rituximab; skin lesion