title: Subdistal Appendages Stabilize the Ups and Downs of Ciliary Life.
abstract: Centrioles acquire subdistal appendages (sDAPs) during primary cilium formation. In this issue of Developmental Cell, Mazo et al. (2016) demonstrate that sDAPs keep cilia submerged within deep membrane invaginations. When sDAPs and centrosome cohesion are disrupted, cilia surface to the plasma membrane, which may alter mechanical and chemical signal transduction.
authors.affiliation: Department of Cell and Developmental Biology, University of Colorado School of Medicine, Aurora, CO 80045, USA. Electronic address: domenico.galati@ucdenver.edu.
authors.forename: Domenico F
authors.initials: DF
authors.lastname: Galati
authors.affiliation: Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
authors.forename: Brian J
authors.initials: BJ
authors.lastname: Mitchell
authors.affiliation: Department of Cell and Developmental Biology, University of Colorado School of Medicine, Aurora, CO 80045, USA.
authors.forename: Chad G
authors.initials: CG
authors.lastname: Pearson
mesh_terms: D002462:Cell Membrane; D002502:Centrioles; D018385:Centrosome; D002923:Cilia; D006801:Humans; D009024:Morphogenesis