title: Fish Immunoglobulins.
abstract: The B cell receptor and secreted antibody are at the nexus of humoral adaptive immunity. In this review, we summarize what is known of the immunoglobulin genes of jawed cartilaginous and bony fishes. We focus on what has been learned from genomic or cDNA sequence data, but where appropriate draw upon protein, immunization, affinity and structural studies. Work from major aquatic model organisms and less studied comparative species are both included to define what is the rule for an immunoglobulin isotype or taxonomic group and what exemplifies an exception.
authors.affiliation: Comparative Immunogenetics Laboratory, Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843, USA. smashoof@gmail.com.
authors.forename: Sara
authors.initials: S
authors.lastname: Mashoof
authors.affiliation: Comparative Immunogenetics Laboratory, Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843, USA. mcriscitiello@cvm.tamu.edu.|Department of Microbial Pathogenesis and Immunology, College of Medicine, Texas A&M University, College Station, TX 77807, USA. mcriscitiello@cvm.tamu.edu.
authors.forename: Michael F
authors.initials: MF
authors.lastname: Criscitiello
keywords: antibody; evolution; fish; humoral immunity; immunoglobulin; immunoglobulin heavy chain; immunoglobulin light chain; natural selection; shark; teleost