title: Somatostatin Agonist Pasireotide Inhibits Exercise-Stimulated Growth in the Male Siberian Hamster (Phodopus sungorus).
abstract: The Siberian hamster (Phodopus sungorus) is a seasonal mammal, exhibiting a suite of physiologically and behaviourally distinct traits dependent on the time of year and governed by changes in perceived day length (photoperiod). These attributes include significant weight loss, reduced food intake, gonadal atrophy and pelage change with short-day photoperiod as in winter. The central mechanisms driving seasonal phenotype change during winter are mediated by a reduced availability of hypothalamic triiodothyronine (T3), although the downstream mechanisms responsible for physiological and behavioural changes are yet to be fully clarified. With access to a running wheel (RW) in short photoperiod, Siberian hamsters that have undergone photoperiod-mediated weight loss over-ride photoperiod-drive for reduced body weight and regain weight similar to a hamster held in long days. These changes occur despite retaining the majority of hypothalamic gene expression profiles appropriate for short-day hamsters. Utilising the somatostatin agonist pasireotide, we recently provided evidence for an involvement of the growth hormone (GH) axis in the seasonal regulation of bodyweight. In the present study, we employed pasireotide to test for the possible involvement of the GH axis in RW-induced body weight regulation. Pasireotide successfully inhibited exercise-stimulated growth in short-day hamsters and this was accompanied by altered hypothalamic gene expression of key GH axis components. Our data provide support for an involvement of the GH axis in the RW response in Siberian hamsters.
authors.affiliation: The Rowett Institute, University of Aberdeen, Aberdeen, UK.
authors.forename: R
authors.initials: R
authors.lastname: Dumbell
authors.affiliation: University of Veterinary Medicine Hannover, Hannover, Germany.
authors.forename: I
authors.initials: I
authors.lastname: Petri
authors.affiliation: University of Veterinary Medicine Hannover, Hannover, Germany.
authors.forename: F
authors.initials: F
authors.lastname: Scherbarth
authors.affiliation: University of Veterinary Medicine Hannover, Hannover, Germany.
authors.forename: V
authors.initials: V
authors.lastname: Diedrich
authors.affiliation: Novartis Pharma AG, Basel, Switzerland.
authors.forename: H A
authors.initials: HA
authors.lastname: Schmid
authors.affiliation: University of Veterinary Medicine Hannover, Hannover, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Steinlechner
authors.affiliation: The Rowett Institute, University of Aberdeen, Aberdeen, UK.
authors.forename: P
authors.initials: P
authors.lastname: Barrett
mesh_terms: D000818:Animals; D001823:Body Composition / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects*; D006224:Cricetinae; D004435:Eating; D013007:Growth Hormone-Releasing Hormone / Q000096:biosynthesis; D007031:Hypothalamus / Q000378:metabolism; D007453:Iodide Peroxidase / Q000096:biosynthesis; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D009478:Neuropeptide Y / Q000096:biosynthesis; D009929:Organ Size / Q000187:drug effects; D017111:Phodopus; D017440:Photoperiod; D011333:Pro-Opiomelanocortin / Q000096:biosynthesis; D011986:Receptors, Somatotropin / Q000096:biosynthesis*; D013004:Somatostatin / Q000819:agonists / Q000031:analogs & derivatives* / Q000096:biosynthesis / Q000494:pharmacology
chemical_list: D009478:Neuropeptide Y; D011986:Receptors, Somatotropin; D013004:Somatostatin; D011333:Pro-Opiomelanocortin; D013007:Growth Hormone-Releasing Hormone; C517782:pasireotide; D007453:Iodide Peroxidase
keywords: 
  Phodopus sungorus
  ; Dehnel's phenomenon; circadian; exercise; growth hormone; seasonality