title: Triptan-induced Reversible Cerebral Vasoconstriction Syndrome: Two Case Reports with a Literature Review.
abstract: We encountered two patients with sumatriptan-induced reversible cerebral vasoconstriction syndrome (RCVS). The present patients were taking sumatriptan for the first time because they had been tentatively diagnosed with a migraine. On reviewing the literature, we found nine other cases of triptan-induced RCVS, predominantly among women aged 30 to 40 years. RCVS has been precipitated by triptan at the first ever use, after daily use, and even with long-term use at a normal dose. Patients with acute onset of severe headache should be thoroughly evaluated, and triptan should be administered appropriately. If triptan-induced RCVS is suspected, vascular imaging should be repeated after several days.
authors.affiliation: Department of Neurology and Cerebrovascular Medicine, Saitama Medical University International Medical Center, Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Kato
authors.forename: Takeshi
authors.initials: T
authors.lastname: Hayashi
authors.forename: Satoko
authors.initials: S
authors.lastname: Mizuno
authors.forename: Yohsuke
authors.initials: Y
authors.lastname: Horiuchi
authors.forename: Masayuki
authors.initials: M
authors.lastname: Ohira
authors.forename: Norio
authors.initials: N
authors.lastname: Tanahashi
authors.forename: Masaki
authors.initials: M
authors.lastname: Takao
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D013577:Syndrome; D014057:Tomography, X-Ray Computed; D014363:Tryptamines / Q000009:adverse effects*; D014661:Vasoconstriction / Q000187:drug effects / Q000502:physiology*; D020301:Vasospasm, Intracranial / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology
chemical_list: D014363:Tryptamines