title: Current drug design to target the Semaphorin/Neuropilin/Plexin complexes.
abstract: The Semaphorin/Neuropilin/Plexin (SNP) complexes control a wide range of biological processes. Consistently, activity deregulation of these complexes is associated with many diseases. The increasing knowledge on SNP had in turn validated these molecular complexes as novel therapeutic targets. Targeting SNP activities by small molecules, antibodies and peptides or by soluble semaphorins have been proposed as new therapeutic approach. This review is focusing on the latest demonstration of this potential and discusses some of the key questions that need to be addressed before translating SNP targeting into clinically relevant approaches.
authors.affiliation: a INSERM U1109 - MN3T Lab, Fédération de Médecine Translationnelle, Labex Medalis, University of Strasbourg , France.
authors.forename: Lionel A T
authors.initials: LA
authors.lastname: Meyer
authors.affiliation: a INSERM U1109 - MN3T Lab, Fédération de Médecine Translationnelle, Labex Medalis, University of Strasbourg , France.
authors.forename: Justine
authors.initials: J
authors.lastname: Fritz
authors.affiliation: a INSERM U1109 - MN3T Lab, Fédération de Médecine Translationnelle, Labex Medalis, University of Strasbourg , France.
authors.forename: Marie
authors.initials: M
authors.lastname: Pierdant-Mancera
authors.affiliation: a INSERM U1109 - MN3T Lab, Fédération de Médecine Translationnelle, Labex Medalis, University of Strasbourg , France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Bagnard
mesh_terms: D000818:Animals; D019138:Antibodies, Blocking / Q000494:pharmacology; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D015195:Drug Design; D006801:Humans; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D039921:Neuropilins / Q000378:metabolism*; D039961:Semaphorins / Q000378:metabolism*; D054852:Small Molecule Libraries / Q000494:pharmacology
chemical_list: D019138:Antibodies, Blocking; D015815:Cell Adhesion Molecules; D009419:Nerve Tissue Proteins; D039921:Neuropilins; D039961:Semaphorins; D054852:Small Molecule Libraries; C091529:plexin
keywords: neuropilin; plexin; semaphorin signaling; targeted therapies