title: Erythroderma and non-Hodgkin T-cell lymphoma: what else, apart from Mycosis Fungoides and Sézary syndrome?
abstract: BACKGROUND
  Peripheral T-cell lymphomas, not otherwise specified (PTCL-NOS), are a rare condition characterised by specific histology, nodal presentation, and a poor prognosis. In total, 10-18% of patients present with cutaneous involvement which is regarded as a poor prognostic marker. However, cutaneous PTCL-NOS lesions have been rarely reported in the literature.
  
  
  OBJECTIVE
  We sought to describe PTCL-NOS cases characterised by erythrodermic dissemination to the skin.
  
  
  METHODS
  Three cases of PTCL-NOS were investigated; all male, with a mean and median age of 55 and 51 years, respectively.
  
  
  RESULTS
  All patients underwent aggressive chemotherapeutic protocols with only transient improvement of the disease, and died within two years of follow-up.
  
  
  CONCLUSIONS
  Dermatologists should be reminded that erythroderma and lymph node enlargement do not represent an exclusive paradigm for erythrodermic cutaneous T-cell lymphoma, and that these features can be due to a systemic lymphoma that should be considered in the differential diagnosis.
authors.affiliation: Dermatology Unit, Department of Experimental, Diagnostic, Specialty Medicine, University of Bologna, Italy, Dermatology Unit, Department of Surgery, Translational Medicine, University of Florence, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Pileri
authors.affiliation: Haematogy Unit, Department of Experimental, Diagnostic, Specialty Medicine, University of Bologna, Italy.
authors.forename: Cinzia
authors.initials: C
authors.lastname: Pellegrini
authors.affiliation: Haematopathology Unit, Department of Experimental, Diagnostic, Specialty Medicine, University of Bologna, Italy.
authors.forename: Claudio
authors.initials: C
authors.lastname: Agostinelli
authors.affiliation: Dermatology Unit, Department of Surgery, Translational Medicine, University of Florence, Italy.
authors.forename: Vieri
authors.initials: V
authors.lastname: Grandi
authors.affiliation: Dermatology Unit, Department of Experimental, Diagnostic, Specialty Medicine, University of Bologna, Italy.
authors.forename: Annalisa
authors.initials: A
authors.lastname: Patrizi
authors.affiliation: Haematogy Unit, Department of Experimental, Diagnostic, Specialty Medicine, University of Bologna, Italy.
authors.forename: Pier Luigi
authors.initials: PL
authors.lastname: Zinzani
authors.affiliation: Dermatology Unit, Department of Surgery, Translational Medicine, University of Florence, Italy.
authors.forename: Nicola
authors.initials: N
authors.lastname: Pimpinelli
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000627:therapeutic use; D003841:Deoxycytidine / Q000031:analogs & derivatives / Q000627:therapeutic use; D003873:Dermatitis, Exfoliative / Q000209:etiology*; D003937:Diagnosis, Differential; D004317:Doxorubicin / Q000627:therapeutic use; D005047:Etoposide / Q000627:therapeutic use; D017809:Fatal Outcome; D006801:Humans; D000072281:Lymphadenopathy / Q000209:etiology; D016411:Lymphoma, T-Cell, Peripheral / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000175:diagnosis*; D009944:Organoplatinum Compounds / Q000627:therapeutic use; D011239:Prednisolone / Q000627:therapeutic use; D011241:Prednisone / Q000627:therapeutic use; D012751:Sezary Syndrome / Q000175:diagnosis*; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D009944:Organoplatinum Compounds; D003841:Deoxycytidine; D014750:Vincristine; D005047:Etoposide; D004317:Doxorubicin; D003520:Cyclophosphamide; D011239:Prednisolone; D011241:Prednisone
keywords: PTCL-NOS; erythroderma; lymph node enlargement; peripheral T-cell lymphomas not otherwise specified; systemic lymphoma