title: Sex-specific Association Between Uric Acid and Outcomes After Acute Ischemic Stroke: A Prospective Study from CATIS Trial.
abstract: The relationship between serum uric acid (UA) and outcomes after acute ischemic stroke remains debatable in human studies, and the sex effect on this association has yet to be explored. Here, we investigated these associations in a prospective study from the China Antihypertensive Trial in Acute Ischemic Stroke. Baseline UA levels were measured in 3284 acute ischemic stroke patients. Primary outcome was defined as a combination of death and major disability (modified Rankin Scale score ≥3) at 3 months. UA levels were significantly higher in men than women (310.6 ± 96.1 vs 257.5 ± 89.9 μmol/L, P < 0.001). The association between serum UA and the primary outcome was appreciably modified by sex (P-interaction = 0.007). After multivariate adjustment, a high serum UA was associated with a decreased risk of primary outcome in men [odds ratio (OR), 0.63; 95% confidence interval (CI), 0.44-0.91; P-trend = 0.01] but not in women (OR, 1.29; 95% CI, 0.83-2.01; P-trend = 0.15), when two extreme quartiles were compared. Subgroup and sensitivity analyses further confirmed these sex-specific findings. Our study indicated that there was a sex-specific association between serum UA and prognosis of acute ischemic stroke. Elevated serum UA was positively associated with better prognosis in men, but not in women.
authors.affiliation: Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, China.
authors.forename: Li-Hua
authors.initials: LH
authors.lastname: Chen
authors.affiliation: Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, China.|Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.
authors.forename: Chongke
authors.initials: C
authors.lastname: Zhong
authors.affiliation: Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, China.|Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.
authors.forename: Tan
authors.initials: T
authors.lastname: Xu
authors.affiliation: Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, China.|Department of Neurology, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China.
authors.forename: Tian
authors.initials: T
authors.lastname: Xu
authors.affiliation: Department of Neurology, Affiliated Hospital of North China University of Science and Technology, Hebei, China.
authors.forename: Yanbo
authors.initials: Y
authors.lastname: Peng
authors.affiliation: Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, China.
authors.forename: Aili
authors.initials: A
authors.lastname: Wang
authors.affiliation: Department of Neurology, Yutian County Hospital, Hebei, China.
authors.forename: Jinchao
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Peng
authors.affiliation: Department of Epidemiology, School of Public Health, Taishan Medical College, Shandong, China.
authors.forename: Qunwei
authors.initials: Q
authors.lastname: Li
authors.affiliation: Department of Neurology, Kerqin District First People's Hospital of Tongliao City, Inner Mongolia, China.
authors.forename: Zhong
authors.initials: Z
authors.lastname: Ju
authors.affiliation: Department of Neurology, Affiliated Hospital of Xuzhou Medical College, Jiangsu, China.
authors.forename: Deqin
authors.initials: D
authors.lastname: Geng
authors.affiliation: Department of Neurology, the 88th Hospital of PLA, Shandong, China.
authors.forename: Jintao
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Neurology, Tangshan Worker's Hospital, Hebei, China.
authors.forename: Yongqiu
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, China.|Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.
authors.forename: Yonghong
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, China.|Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.
authors.forename: Jiang
authors.initials: J
authors.lastname: He
mesh_terms: D000328:Adult; D000368:Aged; D002545:Brain Ischemia / Q000097:blood* / Q000503:physiopathology / Q000628:therapy; D002681:China; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012307:Risk Factors; D012727:Sex Characteristics; D020521:Stroke / Q000097:blood* / Q000503:physiopathology / Q000628:therapy; D016896:Treatment Outcome; D014527:Uric Acid / Q000097:blood*
chemical_list: D014527:Uric Acid