title: Levels of vitamin C In the blood plasma patients treated with coronary artery bypass grafting increases significantly after surgery.
abstract: One strong risk factor of coronary artery disease (CAD), which affects the levels of vitamin C in the blood is cigarette smoking. The supplementary effects of coronary artery bypass grafting (CABG) is smoking cessation by patients. Therefore, the aim of this study was to examine the level of vitamin C in the blood plasma one day before and one month after CABG. Human blood were collected from 20 patients (men); 1day before and 1 month after CABG. All patients were smoker and after CABG they declared their not smoking. The concentration of vitamin C in the blood plasma was assayed by FIA method with spectrophotometric detection. The mean value of the vitamin C concentration 1day before CABG was 12.36±2.84μmol/L (mean±SD), 1 month after CABG 40.07±10.95μmol/L (mean±SD). The average increase in the concentration of vitamin C was 3.27±0.73 times (mean±SD) and showed significant positive correlations (Pearson r=0.657, p=0.002). It should be consider incorporating the recommendations of preoperative smoking cessation for at least one month prior to CABG and/or additional supplementation. In addition it would be relevant to monitor the level of vitamin C in the patients' blood in the preoperative period.
authors.affiliation: Department of Biophysics, Medical University of Białystok, Poland. Electronic address: kleszczt@umb.edu.pl.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Kleszczewski
authors.affiliation: Department of Biophysics, Medical University of Białystok, Poland.
authors.forename: Beata
authors.initials: B
authors.lastname: Modzelewska
authors.affiliation: Department of Cardiology, Medical University of Białystok, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Lisowska
authors.affiliation: Department of Cardiac Surgery, Medical University of Białystok, Poland; Department of Cardiac Surgery, The Regional Specialist Hospital in Olsztyn, Poland.
authors.forename: Leszek
authors.initials: L
authors.lastname: Buzun
authors.affiliation: Institute of Health Care, Higher Vocational School of Suwałki, Poland.
authors.forename: Ewa
authors.initials: E
authors.lastname: Kleszczewska
mesh_terms: D000328:Adult; D000368:Aged; D001205:Ascorbic Acid / Q000097:blood*; D001026:Coronary Artery Bypass; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
chemical_list: D001205:Ascorbic Acid
keywords: Cabg; Smoking; Smoking cessation; Vitamin C