title: The disparate origins of ovarian cancers: pathogenesis and prevention strategies.
abstract: Ovarian cancer is the fifth cause of cancer-related death in women and comprises a histologically and genetically broad range of tumours, including those of epithelial, sex cord-stromal and germ cell origin. Recent evidence indicates that high-grade serous ovarian carcinoma, clear cell carcinoma and endometrioid carcinoma primarily arise from tissues that are not normally present in the ovary. These histogenetic pathways are informing risk-reduction strategies for the prevention of ovarian and ovary-associated cancers and have highlighted the importance of the seemingly unique ovarian microenvironment.
authors.affiliation: Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V5Z 1M9, Canada.
authors.forename: Anthony N
authors.initials: AN
authors.lastname: Karnezis
authors.affiliation: Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.
authors.forename: Kathleen R
authors.initials: KR
authors.lastname: Cho
authors.affiliation: Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V5Z 1M9, Canada.
authors.forename: C Blake
authors.initials: CB
authors.lastname: Gilks
authors.affiliation: Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109, USA.
authors.forename: Celeste Leigh
authors.initials: CL
authors.lastname: Pearce
authors.affiliation: Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V5Z 1M9, Canada.
authors.forename: David G
authors.initials: DG
authors.lastname: Huntsman
mesh_terms: D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000209:etiology / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control; D059016:Tumor Microenvironment / Q000502:physiology