title: Allele and genotype frequencies of polymorphisms in cytokine genes in ethnic Russian individuals from Moscow, Russia.
abstract: Two hundred and twenty eight ethnic Russian individuals from Moscow, Russia, were genotyped at 14 single nucleotide polymorphisms CCL2 A-2578G; VEGFA C-2578A, G-634C, and C+936T; TNF G+419A and G-308A; IL1A G-889A; IL1RN T+1018C; IL6G-174C and G-572C; IFNG T+874A; IL1B C-511T; IL10 A+1082G; TGFB1 C-509T. Genotypes were determined using real-time polymerase chain reaction with TaqMan probes and polymerase chain reaction followed by melting analysis of dual-labeled probe. Genotype distribution was in accordance with Hardy-Weinberg equilibrium for all studied polymorphisms. Genotype data are available in the Allele Frequencies Net Database under identifier AFND 3367 and the population name "Russia Moscow Cytokine".
authors.affiliation: Institute of Chemical Biology and Fundamental Medicine, Lavrentjeva Street, 8, Novosibirsk 630090, Russia. Electronic address: weiner.alexserg@gmail.com.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Shadrina
authors.affiliation: Institute of Chemical Biology and Fundamental Medicine, Lavrentjeva Street, 8, Novosibirsk 630090, Russia.
authors.forename: Elena
authors.initials: E
authors.lastname: Voronina
authors.affiliation: Pirogov Russian National Research Medical University, Ostrovitianova Street, 1, Moscow 117997, Russia.
authors.forename: Igor
authors.initials: I
authors.lastname: Zolotukhin
authors.affiliation: Institute of Chemical Biology and Fundamental Medicine, Lavrentjeva Street, 8, Novosibirsk 630090, Russia.
authors.forename: Maxim
authors.initials: M
authors.lastname: Filipenko
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016207:Cytokines / Q000235:genetics*; D030541:Databases, Genetic; D005006:Ethnicity; D005260:Female; D005787:Gene Frequency; D005828:Genetics, Population; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009031:Moscow; D011110:Polymorphism, Genetic; D012426:Russia; D055815:Young Adult
chemical_list: D016207:Cytokines
keywords: Allele; Cytokine; Ethnic Russians; Polymorphism; SNP