title: Cardiovascular and Stroke Risk in Japanese Hemodialysis Patients With Atrial Fibrillation.
abstract: Atrial fibrillation is one of the most common arrhythmias in hemodialysis patients. We evaluated its clinical outcomes among hemodialysis patients with atrial fibrillation in Japan. Using data derived from the Japanese Dialysis Outcomes and Practice Patterns Study, we analyzed backgrounds and outcomes among hemodialysis patients with and without atrial fibrillation in Japan. Among 7002 hemodialysis patients, the prevalence of atrial fibrillation was 5.7% and the incidence was 0.2 per 100 patient-years. Atrial fibrillation was independently associated with all-cause mortality (hazard ratio, 1.32; 95% confidence interval, 1.02-1.71) and cardiovascular events (hazard ratio, 1.39; 95% confidence interval, 1.15-1.68), but not with stroke events (hazard ratio, 0.77; 95% confidence interval, 0.55-1.06) after adjustment for other variables. We conclude that patients with atrial fibrillation experienced higher mortality and more cardiovascular events than did patients without atrial fibrillation, although the risk of stroke was lower than expected.
authors.affiliation: Department of Nephrology, Ohkubo Hospital, Tokyo, Japan.
authors.forename: Jumpei
authors.initials: J
authors.lastname: Hasegawa
authors.affiliation: Arbor Research Collaborative for Health, Ann Arbor, Michigan, USA.
authors.forename: Brian
authors.initials: B
authors.lastname: Bieber
authors.affiliation: Arbor Research Collaborative for Health, Ann Arbor, Michigan, USA.
authors.forename: Maria
authors.initials: M
authors.lastname: Larkina
authors.affiliation: Arbor Research Collaborative for Health, Ann Arbor, Michigan, USA.
authors.forename: Bruce M
authors.initials: BM
authors.lastname: Robinson
authors.affiliation: Department of Nephrology, Ohkubo Hospital, Tokyo, Japan.
authors.forename: Sachiko
authors.initials: S
authors.lastname: Wakai
authors.affiliation: Division of Nephrology, Department of Medicine, Showa University School of Medicine, Japan.
authors.forename: Tadao
authors.initials: T
authors.lastname: Akizawa
authors.affiliation: Shonantoubu General Hospital, Kanagawa, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Saito
authors.affiliation: Department of Healthcare Epidemiology, Kyoto University Graduate School of Medicine and Public Health, Kyoto, Japan.
authors.forename: Shunichi
authors.initials: S
authors.lastname: Fukuhara
authors.affiliation: Department of Blood Purification, Tokyo Women's Medical University, Tokyo, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Akiba
mesh_terms: D000368:Aged; D001281:Atrial Fibrillation / Q000453:epidemiology*; D002318:Cardiovascular Diseases / Q000453:epidemiology; D015897:Comorbidity; D005260:Female; D006801:Humans; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011446:Prospective Studies; D006435:Renal Dialysis; D012306:Risk; D020521:Stroke / Q000453:epidemiology*
keywords: Anticoagulation; Atrial fibrillation; Cardiovascular disease; Hemodialysis; Stroke