title: Nuclear imaging of thrombosis in small animal.
abstract: Thromboembolic disorders are a major cause of morbidity and mortality worldwide. The progress in noninvasive imaging techniques has led to the development of radionuclide imaging based on SPECT and PET approaches to observe molecular and cellular processes that may underlie the onset and progression of disease. The advantages of using normal and genetically modified small animal research have spurred the development of dedicated small animal imaging systems. Animal models of venous and arterial thrombosis are largely used and have improved our understanding of the etiology and pathogenesis of thrombosis. Here, we review the literature regarding nuclear imaging of thrombosis in mice and rats.
authors.affiliation: a Inserm, U1048 and Université Toulouse III , I2MC, Toulouse , France.|b Faculté de Chirurgie Dentaire, Université de Toulouse III , Toulouse , France.
authors.forename: Marie-Cécile
authors.initials: MC
authors.lastname: Valéra
authors.affiliation: a Inserm, U1048 and Université Toulouse III , I2MC, Toulouse , France.|c Laboratoire d'Hématologie CHU de Toulouse , Toulouse , France.
authors.forename: Bernard
authors.initials: B
authors.lastname: Payrastre
authors.affiliation: a Inserm, U1048 and Université Toulouse III , I2MC, Toulouse , France.|d Fédération des services de cardiologie, Département de Médecine Nucléaire Centre d'imagerie cardiaque, CHU de Toulouse , Toulouse , France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Lairez
mesh_terms: D000818:Animals; D001792:Blood Platelets / Q000378:metabolism* / Q000473:pathology; D004195:Disease Models, Animal; D019788:Fluorodeoxyglucose F18 / Q000378:metabolism / Q000493:pharmacokinetics; D006801:Humans; D007205:Indium Radioisotopes / Q000378:metabolism / Q000493:pharmacokinetics; D008024:Ligands; D051379:Mice; D015609:Organotechnetium Compounds / Q000378:metabolism / Q000493:pharmacokinetics; D010718:Phosphatidylserines / Q000378:metabolism; D015539:Platelet Activation; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000378:metabolism; D049268:Positron-Emission Tomography / Q000295:instrumentation / Q000379:methods*; D019275:Radiopharmaceuticals / Q000378:metabolism / Q000493:pharmacokinetics; D051381:Rats; D013923:Thromboembolism / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology; D013927:Thrombosis / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology; D015899:Tomography, Emission-Computed, Single-Photon / Q000295:instrumentation / Q000379:methods*
chemical_list: D007205:Indium Radioisotopes; D008024:Ligands; D015609:Organotechnetium Compounds; D010718:Phosphatidylserines; D019039:Platelet Glycoprotein GPIIb-IIIa Complex; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
keywords: Animal; nuclear imaging; thrombosis