title: Electrospray ionization-collision-induced dissociation-tandem mass spectrometry study of lead complexes with deprotonated nucleobases.
abstract: The complexes between the lead cation and deprotonated nucleobases (and deprotonated nucleosides) are studied by using electrospray ionization-collision-induced dissociation-tandem mass spectrometry. It has been found that the deprotonated N9 atom is not the site of lead cation attachment. In ions [A - H + Pb]+and [C - H + Pb]+, the lead cation is coordinated by the adenine N1 atom and cytosine  N3 atom and interaction between the lead cation and deprotonated amino groups seems very likely. Deprotonated thymine shows a higher affinity toward lead cation than deprotonated uracil. In the lead-nucleoside complexes lead cation interacts with a sugar moiety.
authors.affiliation: Institute of Chemistry and Technical Electrochemistry, Poznań University of Technology, Berdychowo 4, 60-965 Poznań, Poland. magdalena.franska@put.poznan.pl.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Frańska
mesh_terms: D001665:Binding Sites; D007854:Lead / Q000032:analysis* / Q000737:chemistry*; D009711:Nucleotides / Q000032:analysis* / Q000737:chemistry*; D011522:Protons; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*; D053719:Tandem Mass Spectrometry / Q000379:methods*
chemical_list: D009711:Nucleotides; D011522:Protons; D007854:Lead