title: The association of plasma oxidative status and inflammation with the development of atrial fibrillation in patients presenting with ST elevation myocardial infarction.
abstract: Atrial fibrillation (AF) is the most common supraventricular arrhythmia following ST elevation myocardial infarction (STEMI). Oxidative stress and inflammation may cause structural and electrical remodeling in the atria making these critical processes in the pathology of AF. In this study, we aimed to evaluate the association between total oxidative status (TOS), total antioxidative capacity (TAC) and high-sensitivity C-reactive protein (hs-CRP) in the development of AF in patients presenting with STEMI. This prospective cohort study consisted of 346 patients with STEMI. Serum TAC and TOS were assessed by Erel's method. Patients were divided into two groups: those with and those without AF. Predictors of AF were determined by multivariate regression analysis. In the present study, 9.5% of patients developed AF. In the patients with AF, plasma TOS and oxidative stress index (OSI) values were significantly higher and plasma TAC levels were significantly lower compared to those without AF (p = .003, p = .002, p < .0001, respectively). Multivariate regression analysis results showed that, female gender (Odds ratio [OR] = 3.07; 95% Confidence Interval [CI] = 1.26-7.47; p = .01), left atrial diameter (OR =1.28; 95% CI =1.12-1.47; p < .0001), hs-CRP (OR =1.02; 95% CI =1.00-1.03; p = .001) and OSI (OR =1.10; 95% CI =1.04-1.18; p = .001) were associated with the development of AF in patients presenting with STEMI. The main finding of this study is that oxidative stress and inflammation parameters were associated with the development of AF in patients presenting with STEMI. Other independent predictors of AF were female gender, left atrial diameter and hs-CRP.
authors.affiliation: a Department of Cardiology , Isparta State Hospital , Isparta , Turkey.
authors.forename: Hasan Aydin
authors.initials: HA
authors.lastname: Bas
authors.affiliation: b Department of Cardiology , Dinar state Hospital , Afyonkarahisar , Turkey.
authors.forename: Fatih
authors.initials: F
authors.lastname: Aksoy
authors.affiliation: c Department of Cardiology , Ahi Evran University , Kirsehir , Turkey.
authors.forename: Atilla
authors.initials: A
authors.lastname: Icli
authors.affiliation: d Department of Cardiology , Suleyman Demirel University School of Medicine , Isparta , Turkey.
authors.forename: Ercan
authors.initials: E
authors.lastname: Varol
authors.affiliation: d Department of Cardiology , Suleyman Demirel University School of Medicine , Isparta , Turkey.
authors.forename: Abdullah
authors.initials: A
authors.lastname: Dogan
authors.affiliation: d Department of Cardiology , Suleyman Demirel University School of Medicine , Isparta , Turkey.
authors.forename: Dogan
authors.initials: D
authors.lastname: Erdogan
authors.affiliation: a Department of Cardiology , Isparta State Hospital , Isparta , Turkey.
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Ersoy
authors.affiliation: d Department of Cardiology , Suleyman Demirel University School of Medicine , Isparta , Turkey.
authors.forename: Akif
authors.initials: A
authors.lastname: Arslan
authors.affiliation: d Department of Cardiology , Suleyman Demirel University School of Medicine , Isparta , Turkey.
authors.forename: Hatem
authors.initials: H
authors.lastname: Ari
authors.affiliation: e Internal Medicine , Isparta State Hospital , Isparta , Turkey.
authors.forename: Nihal
authors.initials: N
authors.lastname: Bas
authors.affiliation: f Department of Clinical Chemistry , Izmir Katip Celebi University School of Medicine , Izmir , Turkey.
authors.forename: Recep
authors.initials: R
authors.lastname: Sutcu
authors.affiliation: d Department of Cardiology , Suleyman Demirel University School of Medicine , Isparta , Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Ozaydin
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001281:Atrial Fibrillation / Q000097:blood* / Q000175:diagnosis / Q000209:etiology / Q000473:pathology; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism*; D005260:Female; D006325:Heart Atria / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007249:Inflammation; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism / Q000473:pathology*; D016017:Odds Ratio; D018384:Oxidative Stress; D011446:Prospective Studies; D012044:Regression Analysis; D012307:Risk Factors; D000072657:ST Elevation Myocardial Infarction / Q000097:blood* / Q000150:complications / Q000175:diagnosis / Q000473:pathology; D012737:Sex Factors
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein
keywords: Antioxidants; atrial fibrillation; inflammation; myocardial infarction; oxidative stress