title: Prostatic Arterial Embolization Treating Moderate-to-Severe Lower Urinary Tract Symptoms Related to Benign Prostate Hyperplasia: A Meta-Analysis.
abstract: OBJECTIVE
  To evaluate the clinical efficiency and safety of PAE treating moderate-to-severe LUTS related to BPH.
  
  
  METHODS
  A systematic literature search was performed using PUBMED, EMBASE, Cochrane database of systematic review, and Web of Science, up to April 2016, to identify eligible studies. The Cochrane Collaboration's RevMan 5.3 was used to analyze the extracted data. Random- or fixed-effect model was selected to fit the pooled out heterogeneity.
  
  
  RESULTS
  20 eligible studies were included in this meta-analysis. Synthetic data showed that there were statistically significant improvements in IPSS (MD = -13.25; 95% CI -14.81 to -11.69; P < 0.00001), QoL score (MD = -2.34; 95% CI -2.69 to -2.00, P < 0.00001), PSA level (MD = -1.33; 95% CI -1.86 to -0.80; P < 0.00001), PV (MD = -28.00; 95% CI -35.94 to -20.07; P < 0.00001), Qmax (MD = 5.51; 95% CI 4.62 to 6.40; P < 0.00001), and PVR (MD = -67.8; 95% CI -81.35 to -53.60; P < 0.00001). There was no significant difference in IIEF score (MD = 0.93; 95% CI 0.43-1.42; P = 0.07). Major complications following PAE include pain in the perineum, retropubic area, and/or urethra (9.4%), and hematuria (9.0%).
  
  
  CONCLUSIONS
  PAE should be considered to be the very promising alternative treatment for those who do not want or cannot tolerate surgical treatment, with its benefits on IPSS, QoL score, PSA level, PV, Qmax, and PVR without affecting erectile function.
authors.affiliation: Institute of Urology (Laboratory of Reconstructive Urology), Sichuan University, Chengdu, 610041, Sichuan, China.
authors.forename: Shijian
authors.initials: S
authors.lastname: Feng
authors.affiliation: Department of Urology Surgery, Guizhou Provincial People's Hospital, Guiyang, Guizhou, China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Tian
authors.affiliation: Department of Cardiology, Guizhou Provincial People's Hospital, Guiyang, Guizhou, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.affiliation: Institute of Urology (Laboratory of Reconstructive Urology), Sichuan University, Chengdu, 610041, Sichuan, China.
authors.forename: Zirui
authors.initials: Z
authors.lastname: Li
authors.affiliation: Department of Urology, Minimally Invasive Surgery Center, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
authors.forename: Tuo
authors.initials: T
authors.lastname: Deng
authors.affiliation: Institute of Urology (Laboratory of Reconstructive Urology), Sichuan University, Chengdu, 610041, Sichuan, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Li
authors.affiliation: Institute of Urology (Laboratory of Reconstructive Urology), Sichuan University, Chengdu, 610041, Sichuan, China. wangkj@scu.edu.cn.
authors.forename: Kunjie
authors.initials: K
authors.lastname: Wang
mesh_terms: D004621:Embolization, Therapeutic / Q000379:methods*; D006801:Humans; D059411:Lower Urinary Tract Symptoms / Q000209:etiology* / Q000628:therapy*; D008297:Male; D011470:Prostatic Hyperplasia / Q000150:complications* / Q000628:therapy*; D016896:Treatment Outcome
keywords: Benign prostate hyperplasia; Lower urinary tract symptoms; Prostatic arterial embolization; Treatment