title: The infectious hypoxia: occurrence and causes during Shigella infection.
abstract: Hypoxia is defined as a tissue oxygenation status below physiological needs. During Shigella infection, an infectious hypoxia is induced within foci of infection. In this review, we discuss how Shigella physiology and virulence are modulated and how the main recruited immune cells, the neutrophils, adapt to this environment.
authors.affiliation: Institut Pasteur, Unité de Pathogénie Microbienne Moléculaire, 28 rue du Dr Roux, 75724 Paris Cedex 15, France; INSERM Unité 1202, 28 rue du Dr Roux, 75724 Paris Cedex 15, France.
authors.forename: Ellen T
authors.initials: ET
authors.lastname: Arena
authors.affiliation: Institut Pasteur, Citech, Imagopole, 28 rue du Dr Roux, 75724 Paris Cedex 15, France.
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Tinevez
authors.affiliation: Institut Pasteur, Unité de Pathogénie Microbienne Moléculaire, 28 rue du Dr Roux, 75724 Paris Cedex 15, France; INSERM Unité 1202, 28 rue du Dr Roux, 75724 Paris Cedex 15, France.
authors.forename: Giulia
authors.initials: G
authors.lastname: Nigro
authors.affiliation: Institut Pasteur, Unité de Pathogénie Microbienne Moléculaire, 28 rue du Dr Roux, 75724 Paris Cedex 15, France; INSERM Unité 1202, 28 rue du Dr Roux, 75724 Paris Cedex 15, France; Collège de France, 11 Place Marcellin Berthelot, F-75231, Paris Cedex 05, France.
authors.forename: Philippe J
authors.initials: PJ
authors.lastname: Sansonetti
authors.affiliation: Institut Pasteur, Unité de Pathogénie Microbienne Moléculaire, 28 rue du Dr Roux, 75724 Paris Cedex 15, France; INSERM Unité 1202, 28 rue du Dr Roux, 75724 Paris Cedex 15, France; Gustave Roussy Cancer Campus, Laboratoire de Thérapie Cellulaire, 114 Rue Edouard Vaillant, 94800 Villejuif, France. Electronic address: marteyn@pasteur.fr.
authors.forename: Benoit S
authors.initials: BS
authors.lastname: Marteyn
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004405:Dysentery, Bacillary / Q000382:microbiology* / Q000473:pathology*; D006801:Humans; D000860:Hypoxia / Q000473:pathology*; D007113:Immunity, Innate; D009504:Neutrophils / Q000276:immunology*; D012760:Shigella / Q000276:immunology* / Q000472:pathogenicity*
keywords: Infectious hypoxia; Neutrophils; Shigella