title: Carbon fluoroxide nanoparticles as fluorescent labels and sonosensitizers for theranostic applications.
abstract: Carbon fluoroxide (CFO) nanoparticles (NPs) produced from silicon carbide wafers are used as both fluorescent probes and sonosensitizers for theranostic application.In vitrocell tests were carried out to investigate the feasibility of ultrasound-based therapy with the use of the CFO NPs. The NPs that penetrated inside the cells were shown to provoke cell destruction after application of an ultrasound treatment. No significant toxic effect was observed when the cells were treated with NP concentrations up to 0.5 mg ml-1without applying ultrasound treatment. The obtained results open a new way toward cancer therapy strategies.
authors.affiliation: University of Lyon, CarMeN Laboratory, UMR INSERM 1060, INSA de Lyon, University of Lyon, France.
authors.forename: Alexander
authors.initials: A
authors.lastname: Kharin
authors.affiliation: Institute of High Technologies, Taras Shevchenko National University of Kyiv, 64, Volodymyrs'ka St., 01601 Kyiv, Ukraine.
authors.forename: Olga
authors.initials: O
authors.lastname: Syshchyk
authors.affiliation: University of Lyon, CarMeN Laboratory, UMR INSERM 1060, INSA de Lyon, University of Lyon, France.
authors.forename: Alain
authors.initials: A
authors.lastname: Geloen
authors.affiliation: Chemistry Faculty, Taras Shevchenko National University of Kyiv, 64, Volodymyrs'ka St., 01601 Kyiv, Ukraine.
authors.forename: Sergey
authors.initials: S
authors.lastname: Alekseev
authors.affiliation: GAP-Biophotonics, University of Geneva, 22, ch. de Pinchat, CH-1211 Geneva 4, Switzerland.
authors.forename: Andrey
authors.initials: A
authors.lastname: Rogov
authors.affiliation: University of Lyon, Nanotechnology Institute of Lyon (INL) UMR 5270, CNRS, INSA Lyon, Villeurbanne, F-69621, France.
authors.forename: Vladimir
authors.initials: V
authors.lastname: Lysenko
authors.affiliation: Moscow State Lomonosov University, Physics Department, Leninskie Gory 1, 119991 Moscow, Russia.
authors.forename: Victor
authors.initials: V
authors.lastname: Timoshenko
keywords: bioimaging; carbon; luminescence; nanoparticles; theranostics; ultrasound