title: Mitochondrial replacement approaches: challenges for clinical implementation.
abstract: The advent of mitochondrial replacement techniques poses many scientific, regulatory, and ethical questions. Previous studies suggest good safety and efficacy profiles of these techniques, but challenges remain for clinical implementation and international consensus is needed on the regulation of these approaches.
authors.affiliation: Department of Neurology, Friedrich-Baur-Institute, Ludwig-Maximilians-University, Munich, 80336, Germany. Thomas.Klopstock@med.LMU.de.|Munich Cluster for Systems Neurology (SyNergy), Munich, 80336, Germany. Thomas.Klopstock@med.LMU.de.|German Center for Neurodegenerative Diseases (DZNE), Munich, 80336, Germany. Thomas.Klopstock@med.LMU.de.
authors.forename: Thomas
authors.identifier: 0000-0003-2805-4652
authors.initials: T
authors.lastname: Klopstock
authors.affiliation: Fachhochschule für Öffentliche Verwaltung und Rechtspflege in Bayern (FHVR), Wasserburg, 83512, Germany.
authors.forename: Barbara
authors.initials: B
authors.lastname: Klopstock
authors.affiliation: Institute of Human Genetics, Technical University Munich, Munich, 81675, Germany.|Institute of Human Genetics, Helmholtz Zentrum Munich, Neuherberg, 85764, Germany.
authors.forename: Holger
authors.initials: H
authors.lastname: Prokisch
mesh_terms: D000818:Animals; D004272:DNA, Mitochondrial / Q000235:genetics*; D005260:Female; D005307:Fertilization in Vitro / Q000941:ethics; D050259:Genes, Mitochondrial; D000882:Haplorhini; D006801:Humans; D040582:Inheritance Patterns; D008297:Male; D051379:Mice; D008928:Mitochondria / Q000235:genetics / Q000637:transplantation*; D028361:Mitochondrial Diseases / Q000235:genetics / Q000473:pathology / Q000517:prevention & control*; D000069321:Mitochondrial Replacement Therapy / Q000941:ethics / Q000379:methods*; D009865:Oocytes / Q000378:metabolism / Q000473:pathology; D013094:Spermatozoa / Q000166:cytology / Q000378:metabolism; D008941:Spindle Apparatus / Q000235:genetics / Q000637:transplantation
chemical_list: D004272:DNA, Mitochondrial