title: Prognostic Value of Eosinophil to Leukocyte Ratio in Patients with ST-Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention.
abstract: OBJECTIVE
  Leukocyte profile has been related to clinical outcome in patients with ST-segment elevation (STE) myocardial infarction (MI). However, whether eosinophil to leukocyte ratio (ELR) predicts clinical outcome in patients who have undergone primary percutaneous coronary intervention (PCI) remains unclear. Therefore, we examined the prognostic value of ELR in this patient population.
  
  
  METHODS
  We retrospectively analyzed the data of 331 consecutive patients who underwent primary PCI for STEMI between January 2009 and March 2015. All leukocyte types were counted and ELR was calculated for all patients 24 h after hospital admission. The primary study endpoint was major adverse cardiac events (MACEs) within up to one year of follow-up duration.
  
  
  RESULTS
  MACEs including cardiac deaths in 9.4% of the patients, MI in 1.5%, and target lesion or vessel revascularization in 10.3%, occurred within one year in 68 patients (20.5%). The mean ELR was significantly lower in patients with MACEs than in patients without MACEs (0.20±0.51 vs.0.49±0.66, respectively; p＜0.001). An ELR ＜0.1 at 24 h was identified as the best cut-off value for mortality prediction. Multivariate analysis identified that an ELR ＜0.1 (odds ratio [OR]=0.38; 95% confidence interval [CI]=0.22-0.67; p＜0.001) and chronic kidney disease (OR=2.38; CI=1.33-4.24; p=0.003) are independent predictors of MACEs.
  
  
  CONCLUSIONS
  In primary PCI patients with STEMI, ELR at 24 h was an independent predictor of MACEs in addition to the usual coronary risk factors and commonly used biomarkers.
authors.affiliation: Department of Cardiology, Hokkaido Cardiovascular Hospital.|Department of Cancer Pathology, Hokkaido University School of Medicine.
authors.forename: Takao
authors.initials: T
authors.lastname: Konishi
authors.affiliation: Department of Cardiology, Hokkaido Cardiovascular Hospital.
authors.forename: Naohiro
authors.initials: N
authors.lastname: Funayama
authors.affiliation: Department of Cardiology, Hokkaido Cardiovascular Hospital.
authors.forename: Tadashi
authors.initials: T
authors.lastname: Yamamoto
authors.affiliation: Department of Cardiology, Hokkaido Cardiovascular Hospital.
authors.forename: Toru
authors.initials: T
authors.lastname: Morita
authors.affiliation: Department of Cardiology, Hokkaido Cardiovascular Hospital.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Hotta
authors.affiliation: Department of Cancer Pathology, Hokkaido University School of Medicine.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nishihara
authors.affiliation: Department of Cancer Pathology, Hokkaido University School of Medicine.
authors.forename: Shinya
authors.initials: S
authors.lastname: Tanaka
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000032:analysis*; D004562:Electrocardiography; D004804:Eosinophils / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D017052:Hospital Mortality; D006801:Humans; D007962:Leukocytes / Q000473:pathology*; D008297:Male; D062645:Percutaneous Coronary Intervention / Q000379:methods*; D011379:Prognosis; D012189:Retrospective Studies; D000072657:ST Elevation Myocardial Infarction / Q000473:pathology* / Q000628:therapy; D015996:Survival Rate
chemical_list: D015415:Biomarkers
keywords: Eosinophil to leukocyte ratio; Major adverse cardiac event; Percutaneous coronary intervention; ST-segment elevation myocardial infarction