title: Improving time to optimal Staphylococcus aureus treatment using a penicillin-binding protein 2a assay.
abstract: The penicillin-binding protein 2a (PBP2a) assay is a quick, accurate and inexpensive test for determining methicillin susceptibility in Staphylococcus aureus. A pre-post-study design was conducted using a PBP2a assay with and without the impact of an antimicrobial stewardship intervention to improve time to optimal therapy for methicillin-susceptible and methicillin-resistant S. aureus isolates. Our results demonstrate significantly improved time to optimal therapy and support the use of a PBP2a assay as part of an programme for all healthcare facilities, especially those with limited resources.
authors.affiliation: Department of Pharmacy Practice, Midwestern University Chicago College of Pharmacy, Downers Grove, IL, USA.|Department of Pharmacy, Rush University Medical Center, Chicago, IL, USA.
authors.forename: Sonia N
authors.initials: SN
authors.lastname: Rao
authors.affiliation: Department of Pharmacy Practice, Midwestern University Chicago College of Pharmacy, Downers Grove, IL, USA.|Department of Pharmacy, Rush University Medical Center, Chicago, IL, USA.
authors.forename: Sheila K
authors.initials: SK
authors.lastname: Wang
authors.affiliation: Division of Infectious Diseases, Rush University Medical Center, Chicago, IL, USA.
authors.forename: Jose
authors.initials: J
authors.lastname: Gonzalez Zamora
authors.affiliation: Department of Pharmacy, Rush University Medical Center, Chicago, IL, USA.
authors.forename: Amy P
authors.initials: AP
authors.lastname: Hanson
authors.affiliation: Department of Pharmacy Practice, Midwestern University Chicago College of Pharmacy, Downers Grove, IL, USA.|Northwestern Medicine Central DuPage Hospital, Winfield, IL, USA.
authors.forename: Radhika S
authors.initials: RS
authors.lastname: Polisetty
authors.affiliation: Division of Infectious Diseases, Rush University Medical Center, Chicago, IL, USA.
authors.forename: Kamaljit
authors.initials: K
authors.lastname: Singh
mesh_terms: D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D016106:Methicillin Resistance; D055624:Methicillin-Resistant Staphylococcus aureus / Q000737:chemistry / Q000302:isolation & purification; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D058889:Molecular Typing; D046915:Penicillin-Binding Proteins / Q000032:analysis*; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000737:chemistry* / Q000187:drug effects* / Q000254:growth & development / Q000302:isolation & purification; D061665:Time-to-Treatment
chemical_list: D000900:Anti-Bacterial Agents; D046915:Penicillin-Binding Proteins