title: Restoration of the Hypothalamic-pituitary-adrenal Response to Hypoglycemia in Type 2 Diabetes by Avoiding Chronic Hypoglycemia.
abstract: An impaired ability to sense and respond to drug-induced hypoglycemia is a common and serious complication in diabetic patients. The hypothalamic-pituitary-adrenal (HPA) axis activity plays a critical role in the counterregulatory response to hypoglycemia. We herein report a case that experienced restoration of a blunted HPA axis by avoiding hypoglycemia with the use of the DPP-4 inhibitor sitagliptin.
authors.affiliation: Department of Diabetology & Endocrinology, Kanazawa Medical University, Japan.
authors.forename: Shin-Ichi
authors.initials: SI
authors.lastname: Tsuda
authors.forename: Kazunori
authors.initials: K
authors.lastname: Konishi
authors.forename: Toshiki
authors.initials: T
authors.lastname: Otoda
authors.forename: Takako
authors.initials: T
authors.lastname: Nagai
authors.forename: Ai
authors.initials: A
authors.lastname: Takeda-Watanabe
authors.forename: Megumi
authors.initials: M
authors.lastname: Kanasaki
authors.forename: Munehiro
authors.initials: M
authors.lastname: Kitada
authors.forename: Atsushi
authors.initials: A
authors.lastname: Nakagawa
authors.forename: Makoto
authors.initials: M
authors.lastname: Nishizawa
authors.forename: Keizo
authors.initials: K
authors.lastname: Kanasaki
authors.forename: Daisuke
authors.initials: D
authors.lastname: Koya
mesh_terms: D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy* / Q000503:physiopathology; D054873:Dipeptidyl-Peptidase IV Inhibitors / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007003:Hypoglycemia / Q000503:physiopathology; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects* / Q000503:physiopathology; D010913:Pituitary-Adrenal System / Q000187:drug effects* / Q000503:physiopathology; D000068900:Sitagliptin Phosphate / Q000627:therapeutic use*
chemical_list: D054873:Dipeptidyl-Peptidase IV Inhibitors; D007004:Hypoglycemic Agents; D000068900:Sitagliptin Phosphate