title: Improving Detection of Iron Deposition in Cirrhotic Liver Using Susceptibility-Weighted Imaging With Emphasis on Histopathological Correlation.
abstract: OBJECTIVE
  The aim of this study was to investigate the value of susceptibility-weighted imaging (SWI) for detection and quantification of iron deposition in cirrhotic liver.
  
  
  METHODS
  Fifty-five cirrhotic patients underwent hepatic magnetic resonance imaging examination including SWI and multiecho T2*-weighted imaging (T2*WI). Detection of iron deposition and number of siderotic nodules were compared between SWI and T2*WI. Correlation among SWI phase value, T2* value, and hepatic iron concentration were determined.
  
  
  RESULTS
  Susceptibility-weighted imaging significantly improved detection of iron deposition compared with T2*WI (90.7% vs 66.7%, P = 0.002), attributing to grade 1 (73.3% vs 26.7%, P = 0.027) and grade 2 (93.8% vs 56.3%, P = 0.037). Iron deposition of grade 3 and 4 could be detected by both SWI and T2*WI. The number of siderotic nodules visualized on SWI was significantly larger than that on T2*WI (107.5 ± 7.4 vs 62.7 ± 4.6, P = 0.002). There were significantly negative correlation between phase value and iron score (r = -0.803), and positive correlation between phase value and T2* value (r = 0.771).
  
  
  CONCLUSIONS
  Susceptibility-weighted imaging can improve detection of minimal and mild iron deposition in cirrhotic liver.
authors.affiliation: From the *Department of Radiology, Ruijin Hospital, Shanghai Jiaotong University; †Department of Radiology, Jinshan Hospital, Fudan University; ‡Department of Diagnostic Radiology, Zhongshan Hospital, Fudan University, Shanghai School of Medicine, Shanghai Medical Imaging Institute, Shanghai, China; §Department of Radiology, Keck Medical Center, University of Southern California, Los Angeles, CA; ∥Department of Pathology, Zhongshan Hospital, Fudan University; and ¶Siemens Ltd, China Healthcare Sector MR Business, Shanghai, China.
authors.forename: Ruo-Kun
authors.initials: RK
authors.lastname: Li
authors.forename: Meng-Su
authors.initials: MS
authors.lastname: Zeng
authors.forename: Jin-Wei
authors.initials: JW
authors.lastname: Qiang
authors.forename: Suzanne L
authors.initials: SL
authors.lastname: Palmer
authors.forename: Frank
authors.initials: F
authors.lastname: Chen
authors.forename: Sheng-Xiang
authors.initials: SX
authors.lastname: Rao
authors.forename: Ling-Li
authors.initials: LL
authors.lastname: Chen
authors.forename: Yong-Ming
authors.initials: YM
authors.lastname: Dai
mesh_terms: D000328:Adult; D000368:Aged; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007501:Iron / Q000378:metabolism*; D008103:Liver Cirrhosis / Q000000981:diagnostic imaging* / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D057054:Molecular Imaging / Q000379:methods; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013223:Statistics as Topic
chemical_list: D007501:Iron