title: [Interventional left atrial appendage closure in a patient with GAVE syndrome].
abstract: History and findings |A 56-year-old female with a gastric antral vascular ectasia (GAVE) suffered from recurrent episodes of upper gastrointestinal bleeding. Because of a history of a permanent atrial fibrillation (CHA2DS2-VASc score 3 points) an oral anticoagulation therapy with phenprocoumon was carried out which even worsened the bleeding frequency and intensity. A change of medication to low-molecular weight heparin did not lead to success. The frequent periods in hospital limited the patient's quality of life.Therapy and course |Two months after the initial diagnosis of the GAVE syndrome and after 5 hospital admissions together with several argon plasma coagulations an AmplatzerTM Cardiac Plug 2 was successfully implanted. With the postinterventional dual antiplatelet therapy with ASA and clopidogrel instead of an oral anticoagulation the bleedings stopped.Conclusion |The interventional left atrial appendage closure appears to be a feasible and safe alternative to oral anticoagulation in patients with a GAVE syndrome and non-valvular atrial fibrillation.
authors.forename: Christian
authors.initials: C
authors.lastname: Fastner
authors.forename: Sebastian
authors.initials: S
authors.lastname: Belle
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Akin
mesh_terms: D005260:Female; D020252:Gastric Antral Vascular Ectasia / Q000150:complications / Q000175:diagnosis* / Q000601:surgery*; D006471:Gastrointestinal Hemorrhage / Q000175:diagnosis* / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D008875:Middle Aged; D055989:Septal Occluder Device; D016896:Treatment Outcome