title: Progranulin and the receptor tyrosine kinase EphA2, partners in crime?
abstract: Progranulin is a secreted protein with roles in tumorigenesis, inflammation, and neurobiology, but its signaling receptors have remained unclear. In this issue, Neill et al. (2016. J. Cell Biol https://doi.org/10.1083/jcb.201603079) identify the tyrosine kinase EphA2 as a strong candidate for such a receptor, providing insight into progranulin and EphA2 signaling.
authors.affiliation: Department of Medicine, McGill University, Montreal, QC H4A 3J1, Canada.|Centre for Translational Biology, Platform in Experimental Therapeutics and Metabolism, McGill University Health Centre Research Institute, Montreal, QC H4A 3J1, Canada.
authors.forename: Babykumari
authors.initials: B
authors.lastname: Chitramuthu
authors.affiliation: Department of Medicine, McGill University, Montreal, QC H4A 3J1, Canada.|Centre for Translational Biology, Platform in Experimental Therapeutics and Metabolism, McGill University Health Centre Research Institute, Montreal, QC H4A 3J1, Canada.
authors.forename: Andrew
authors.initials: A
authors.lastname: Bateman
mesh_terms: D000818:Animals; D063646:Carcinogenesis / Q000473:pathology; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism*; D008954:Models, Biological; D010766:Phosphorylation; D019000:Phosphotyrosine / Q000378:metabolism; D036104:Receptor, EphA2 / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D036341:Intercellular Signaling Peptides and Proteins; D019000:Phosphotyrosine; D036104:Receptor, EphA2