title: Vertebrate embryos as tools for anti-angiogenic drug screening and function.
abstract: The development of new angiogenic inhibitors highlights a need for robust screening assays that adequately capture the complexity of vessel formation, and allow for the quantitative evaluation of the teratogenicity of new anti-angiogenic agents. This review discusses the use of screening assays in vertebrate embryos, specifically focusing upon chicken and zebrafish embryos, for the detection of anti-angiogenic agents.
authors.affiliation: School of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, UK; Molecular Pharmacology Section, Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, USA.
authors.forename: Shaunna L
authors.initials: SL
authors.lastname: Beedie
authors.affiliation: School of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, UK.
authors.forename: Alexandra J
authors.initials: AJ
authors.lastname: Diamond
authors.affiliation: School of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, UK.
authors.forename: Lucas Rosa
authors.initials: LR
authors.lastname: Fraga
authors.affiliation: Molecular Pharmacology Section, Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, USA.
authors.forename: William D
authors.initials: WD
authors.lastname: Figg
authors.affiliation: School of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, UK. Electronic address: n.vargesson@abdn.ac.uk.
authors.forename: Neil
authors.initials: N
authors.lastname: Vargesson
mesh_terms: D020533:Angiogenesis Inhibitors / Q000494:pharmacology*; D000818:Animals; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D004622:Embryo, Mammalian / Q000098:blood supply / Q000187:drug effects*; D004625:Embryo, Nonmammalian / Q000098:blood supply / Q000187:drug effects*; D006801:Humans; D023421:Models, Animal; D018919:Neovascularization, Physiologic / Q000187:drug effects*
chemical_list: D020533:Angiogenesis Inhibitors
keywords: Angiogenesis; Chicken; Mouse; Non-human primates; Rabbit; Rat; Thalidomide; Zebrafish