title: Effect of body mass index on overall survival of patients with allogeneic hematopoietic stem cell transplantation.
abstract: The present work was performed to investigate the association between body mass index (BMI) before transplantation and the overall survival (OS) of patients with allogeneic hematopoietic stem cell transplantation (allo-HSCT).
  
  
  
  Data from 310 adults who were diagnosed with acute leukemia and underwent allo-HSCT between March 2001 and December 2011 were analyzed. According to the suggested BMI categories for Asian population, patients with BMIs of ⩾23 and ⩾25 kg/m2were identified as overweight and obese, respectively. Cox proportional hazards models was used to estimate hazard ratios (HRs) with 95% confidence intervals (CIs).
  
  
  
  The median follow-up time among the patients was 19.7 months (interquartile range=8.1-37.7). A total of 93 (34.8%) people died within the follow-up period. After adjusting for the potential confounders, normal-weight, overweight and obese patients showed significantly lower HRs than those of underweight patients, with a significant trend of OS improvement upon increasing BMI (P=0.019). Overweight and obese patients survived longer, with a significantly decreased HR by ~40% (HR=0.60; 95% CI: 0.38-0.95) compared with underweight and normal-weight patients.
  
  
  
  An increased OS was seen in allo-HSCT patients with BMI⩾23 kg/m2compared to those with lower BMI. Further work are still needed to investigate of the effects of BMI or body composition on the survival of allo-HSCT patients.
authors.affiliation: Department of Clinical Nutrition, The First Affiliated Hospital of Soochow University, Suzhou, China.|Department of Nutrition and Food Hygiene, School of Public Health, Soochow University, Dushu Lake Higher Education Town, Suzhou, China.
authors.forename: J
authors.initials: J
authors.lastname: Yang
authors.affiliation: Department of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China.|Hematopoietic Transplant Institute, Soochow University, Suzhou, China.|Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China.|Collaborative Innovation Center of Hematology, Soochow University, Suzhou, China.
authors.forename: S-L
authors.initials: SL
authors.lastname: Xue
authors.affiliation: Department of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China.|Hematopoietic Transplant Institute, Soochow University, Suzhou, China.|Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China.|Collaborative Innovation Center of Hematology, Soochow University, Suzhou, China.
authors.forename: X
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China.|Hematopoietic Transplant Institute, Soochow University, Suzhou, China.|Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China.|Collaborative Innovation Center of Hematology, Soochow University, Suzhou, China.
authors.forename: Y-N
authors.initials: YN
authors.lastname: Zhou
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Soochow University, Dushu Lake Higher Education Town, Suzhou, China.
authors.forename: L-Q
authors.initials: LQ
authors.lastname: Qin
authors.affiliation: Department of Biostatistics and Epidemiology, School of Public Health, Soochow University, Suzhou, China.
authors.forename: Y-P
authors.initials: YP
authors.lastname: Shen
authors.affiliation: Department of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China.|Hematopoietic Transplant Institute, Soochow University, Suzhou, China.|Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China.|Collaborative Innovation Center of Hematology, Soochow University, Suzhou, China.
authors.forename: D-P
authors.initials: DP
authors.lastname: Wu
mesh_terms: D000208:Acute Disease; D000328:Adult; D015992:Body Mass Index; D001835:Body Weight; D005260:Female; D005500:Follow-Up Studies; D018380:Hematopoietic Stem Cell Transplantation / Q000401:mortality*; D006801:Humans; D007938:Leukemia / Q000628:therapy; D008297:Male; D009765:Obesity; D050177:Overweight; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate; D013851:Thinness; D014184:Transplantation, Homologous