title: The sphingosine-1-phosphate receptor: A novel therapeutic target for multiple sclerosis and other autoimmune diseases.
abstract: Multiple sclerosis (MS) is a prototype autoimmune disease of the central nervous system (CNS). Currently, there is no drug that provides a cure for MS. To date, all immunotherapeutic drugs target relapsing remitting MS (RR-MS); it remains a daunting medical challenge in MS to develop therapy for secondary progressive MS (SP-MS). Since the approval of the non-selective sphingosine-1-phosphate (S1P) receptor modulator FTY720 (fingolimod [Gilenya®]) for RR-MS in 2010, there have been many emerging studies with various selective S1P receptor modulators in other autoimmune conditions. In this article, we will review how S1P receptor may be a promising therapeutic target for SP-MS and other autoimmune diseases such as psoriasis, polymyositis and lupus.
authors.affiliation: Department of Neurology and Clinical Autoimmunity Center of Excellence, University of Michigan Medical School, 4015 Alfred Taubman Biomedical Sciences Research Bldg., 109 Zina Pitcher Place, Ann Arbor, MI 48109-2200, United States. Electronic address: maodraay@umich.edu.
authors.forename: Yang
authors.initials: Y
authors.lastname: Mao-Draayer
authors.affiliation: Department of Neurology and Clinical Autoimmunity Center of Excellence, University of Michigan Medical School, 4015 Alfred Taubman Biomedical Sciences Research Bldg., 109 Zina Pitcher Place, Ann Arbor, MI 48109-2200, United States.
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Sarazin
authors.affiliation: Department of Neurology and Clinical Autoimmunity Center of Excellence, University of Michigan Medical School, 4015 Alfred Taubman Biomedical Sciences Research Bldg., 109 Zina Pitcher Place, Ann Arbor, MI 48109-2200, United States.
authors.forename: David
authors.initials: D
authors.lastname: Fox
authors.affiliation: Department of Neurology and Clinical Autoimmunity Center of Excellence, University of Michigan Medical School, 4015 Alfred Taubman Biomedical Sciences Research Bldg., 109 Zina Pitcher Place, Ann Arbor, MI 48109-2200, United States.
authors.forename: Elena
authors.initials: E
authors.lastname: Schiopu
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000378:metabolism*; D002490:Central Nervous System / Q000378:metabolism; D006801:Humans; D008246:Lysophospholipids / Q000378:metabolism*; D009103:Multiple Sclerosis / Q000378:metabolism*; D020528:Multiple Sclerosis, Chronic Progressive / Q000378:metabolism; D049349:Receptors, Lysosphingolipid / Q000378:metabolism*; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000378:metabolism
chemical_list: D008246:Lysophospholipids; D049349:Receptors, Lysosphingolipid; C060506:sphingosine 1-phosphate; D013110:Sphingosine