title: Amine functionalized cubic mesoporous silica nanoparticles as an oral delivery system for curcumin bioavailability enhancement.
abstract: In the present work, a simple method was used to develop composite curcumin-amine functionalized mesoporous silica nanoparticles (MSN). The nanoparticles were used to improve the bioavailability of curcumin in mice through oral administration. We investigated the effect of particle size on the release profile, solubility and oral bioavailability of curcumin in mice, including amine functionalized mesoporous silica micron-sized-particles (MSM) and MSN (100-200 nm). Curcumin loaded within amine functionalized MSN (MSN-A-Cur) had a better release profile and a higher solubility compared to amine MSM (MSM-A-Cur). The bioavailability of MSN-A-Cur and MSM-A-Cur was considerably higher than that of 'free curcumin'. These results indicate promising features of amine functionalized MSN as a carrier to deliver low solubility drugs with improved bioavailability via the oral route.
authors.affiliation: Department of Chemical Engineering, Widya Mandala Catholic University, Surabaya, Indonesia.
authors.forename: Sandy Budi
authors.initials: SB
authors.lastname: Hartono
authors.forename: Lannie
authors.initials: L
authors.lastname: Hadisoewignyo
authors.forename: Yanan
authors.initials: Y
authors.lastname: Yang
authors.forename: Anand Kumar
authors.initials: AK
authors.lastname: Meka
authors.lastname: Antaresti
authors.forename: Chengzhong
authors.initials: C
authors.lastname: Yu
mesh_terms: D000284:Administration, Oral; D000588:Amines / Q000737:chemistry*; D000818:Animals; D001682:Biological Availability; D003474:Curcumin / Q000493:pharmacokinetics*; D004337:Drug Carriers; D051379:Mice; D053758:Nanoparticles; D010316:Particle Size; D016062:Porosity; D012822:Silicon Dioxide
chemical_list: D000588:Amines; D004337:Drug Carriers; D012822:Silicon Dioxide; D003474:Curcumin