title: Altered spontaneous brain activity pattern in patients with high myopia using amplitude of low-frequency fluctuation: a resting-state fMRI study.
abstract: OBJECTIVE
  Many previous reports have demonstrated significant neural anatomy changes in the brain of high myopic (HM) patients, whereas the spontaneous brain activity changes in the HM patients at rest are not well studied. Our objective was to use amplitude of low-frequency fluctuation (ALFF) method to investigate the changes in spontaneous brain activity in HM patients and their relationships with clinical features.
  
  
  METHODS
  A total of 38 patients with HM (17 males and 21 females) and 38 healthy controls (HCs) (17 males and 21 females) closely matched in age, sex, and education underwent resting-state functional magnetic resonance imaging scans. The ALFF method was used to assess local features of spontaneous brain activity. The relationship between the mean ALFF signal values in many brain regions and the clinical features in HM patients was calculated by correlation analysis.
  
  
  RESULTS
  Compared with HCs, the HM patients had significantly lower ALFF in the right inferior and middle temporal gyrus, left middle temporal gyrus, left inferior frontal gyrus/putamen, right inferior frontal gyrus/putamen/insula, right middle frontal gyrus, and right inferior parietal lobule and higher ALFF values in the bilateral midcingulate cortex, left postcentral gyrus, and left precuneus/inferior parietal lobule. However, no relationship was found between the mean ALFF signal values of the different areas and the clinical manifestations in HM.
  
  
  CONCLUSIONS
  The HM patients were affected with brain dysfunction in many regions, which may indicate the presence of neurobiological changes involving deficits in language understanding and attentional control in HM patients.
authors.affiliation: Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang; Department of Ophthalmology, The First People's Hospital of Jiujiang City, Jiujiang.
authors.forename: Xin
authors.initials: X
authors.lastname: Huang
authors.affiliation: Department of Radiology, The First Affiliated Hospital of Nanchang University, Jiangxi Province Medical Imaging Research Institute.
authors.forename: Fu-Qing
authors.initials: FQ
authors.lastname: Zhou
authors.affiliation: Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang.
authors.forename: Yu-Xiang
authors.initials: YX
authors.lastname: Hu
authors.affiliation: Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang.
authors.forename: Xiao-Xuan
authors.initials: XX
authors.lastname: Xu
authors.affiliation: Second Department of Respiratory Disease, Jiangxi Provincial People's Hospital, Nanchang, Jiangxi, People's Republic of China.
authors.forename: Xiong
authors.initials: X
authors.lastname: Zhou
authors.affiliation: Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang.
authors.forename: Yu-Lin
authors.initials: YL
authors.lastname: Zhong
authors.affiliation: Second Department of Respiratory Disease, Jiangxi Provincial People's Hospital, Nanchang, Jiangxi, People's Republic of China.
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang.
authors.forename: Xiao-Rong
authors.initials: XR
authors.lastname: Wu
keywords: ALFF; functional magnetic resonance imaging; high myopic; resting state