title: Pulsatility Index as a Diagnostic Parameter of Reciprocating Wall Shear Stress Parameters in Physiological Pulsating Waveforms.
abstract: Arterial wall shear stress (WSS) parameters are widely used for prediction of the initiation and development of atherosclerosis and arterial pathologies. Traditional clinical evaluation of arterial condition relies on correlations of WSS parameters with average flow rate (Q) and heart rate (HR) measurements. We show that for pulsating flow waveforms in a straight tube with flow reversals that lead to significant reciprocating WSS, the measurements of HR and Q are not sufficient for prediction of WSS parameters. Therefore, we suggest adding a third quantity-known as the pulsatility index (PI)-which is defined as the peak-to-peak flow rate amplitude normalized by Q. We examine several pulsating flow waveforms with and without flow reversals using a simulation of a Womersley model in a straight rigid tube and validate the simulations through experimental study using particle image velocimetry (PIV). The results indicate that clinically relevant WSS parameters such as the percentage of negative WSS (P[%]), oscillating shear index (OSI) and the ratio of minimum to maximum shear stress rates (min/max), are better predicted when the PI is used in conjunction with HR and Q. Therefore, we propose to use PI as an additional and essential diagnostic quantity for improved predictability of the reciprocating WSS.
authors.affiliation: Department of Mechanical Engineering and Mechatronics, Ariel University, Ariel, Israel.
authors.forename: Idit
authors.initials: I
authors.lastname: Avrahami
authors.affiliation: School of Mechanical Engineering, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Dikla
authors.initials: D
authors.lastname: Kersh
authors.affiliation: School of Mechanical Engineering, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Alexander
authors.identifier: http://orcid.org/0000-0002-6882-4191
authors.initials: A
authors.lastname: Liberzon
mesh_terms: D001158:Arteries / Q000502:physiology*; D050197:Atherosclerosis / Q000175:diagnosis; D006339:Heart Rate; D006439:Hemodynamics; D006801:Humans; D011673:Pulsatile Flow / Q000502:physiology*; D033081:Shear Strength