title: Resveratrol supplementation of high-fat diet-fed pregnant mice promotes brown and beige adipocyte development and prevents obesity in male offspring.
abstract: Maternal high-fat diet impairs brown adipocyte function and correlates with obesity in offspring. Maternal resveratrol administration recovers metabolic activity of offspring brown adipose tissue. Maternal resveratrol promotes beige adipocyte development in offspring white adipose tissue. Maternal resveratrol intervention protects offspring against high-fat diet-induced obesity.
  
  
  
  Promoting beige/brite adipogenesis and thermogenic activity is considered as a promising therapeutic approach to reduce obesity and metabolic syndrome. Maternal obesity impairs offspring brown adipocyte function and correlates with obesity in offspring. We previously found that dietary resveratrol (RES) induces beige adipocyte formation in adult mice. Here, we evaluated further the effect of resveratrol supplementation of pregnant mice on offspring thermogenesis and energy expenditure. Female C57BL/6 J mice were fed a control diet (CON) or a high-fat diet (HFD) with or without 0.2% (w/w) RES during pregnancy and lactation. Male offspring were weaned onto a HFD and maintained on this diet for 11 weeks. The offspring thermogenesis and related regulatory factors in adipose tissue were evaluated. At weaning, HFD offspring had lower thermogenesis in brown and white adipose tissues compared with CON offspring, which was recovered by maternal RES supplementation, along with the appearance of multilocular brown/beige adipocytes and elevated thermogenic gene expression. Adult offspring of RES-treated mothers showed increased energy expenditure and insulin sensitivity when on an obesogenic diet compared with HFD offspring. The elevated metabolic activity was correlated with enhanced brown adipose function and white adipose tissue browning in HFD+RES compared with HFD offspring. In conclusion, RES supplementation of HFD-fed dams during pregnancy and lactation promoted white adipose browning and thermogenesis in offspring at weaning accompanied by persistent beneficial effects in protecting against HFD-induced obesity and metabolic disorders.
authors.affiliation: Animal Nutrition Institute, Sichuan Agricultural University, Chengdu, 611130, Sichuan, China.|Washington Centre for Muscle Biology and Department of Animal Sciences, Washington State University, Pullman, WA, 99164, USA.
authors.forename: Tiande
authors.initials: T
authors.lastname: Zou
authors.affiliation: Animal Nutrition Institute, Sichuan Agricultural University, Chengdu, 611130, Sichuan, China.
authors.forename: Daiwen
authors.initials: D
authors.lastname: Chen
authors.affiliation: Washington Centre for Muscle Biology and Department of Animal Sciences, Washington State University, Pullman, WA, 99164, USA.
authors.forename: Qiyuan
authors.initials: Q
authors.lastname: Yang
authors.affiliation: Washington Centre for Muscle Biology and Department of Animal Sciences, Washington State University, Pullman, WA, 99164, USA.
authors.forename: Bo
authors.initials: B
authors.lastname: Wang
authors.affiliation: School of Food Sciences, Washington State University, Pullman, WA, 99164, USA.
authors.forename: Mei-Jun
authors.initials: MJ
authors.lastname: Zhu
authors.affiliation: Wyoming Pregnancy and Life Course Health Centre, Department of Animal Science, University of Wyoming, Laramie, WY, 82071, USA.
authors.forename: Peter W
authors.initials: PW
authors.lastname: Nathanielsz
authors.affiliation: Washington Centre for Muscle Biology and Department of Animal Sciences, Washington State University, Pullman, WA, 99164, USA.|Beijing Advanced Innovation Centre for Food Nutrition and Human Health, College of Food Science & Nutritional Engineering, China Agricultural University, Beijing, 100194, China.
authors.forename: Min
authors.initials: M
authors.lastname: Du
mesh_terms: D000069797:Adipocytes, Beige / Q000187:drug effects* / Q000378:metabolism; D052437:Adipocytes, Brown / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D059305:Diet, High-Fat; D004734:Energy Metabolism / Q000187:drug effects; D005260:Female; D008297:Male; D051379:Mice; D009765:Obesity / Q000517:prevention & control*; D011247:Pregnancy; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology*; D022722:Thermogenesis / Q000187:drug effects
chemical_list: D013267:Stilbenes; D000077185:Resveratrol
keywords: adipose tissue; beige adipocyte; browning; obesity; offspring; resveratrol; thermogenesis