title: Northern Manhattan Hispanic Caregiver Intervention Effectiveness Study: protocol of a pragmatic randomised trial comparing the effectiveness of two established interventions for informal caregivers of persons with dementia.
abstract: The prevalence of dementia is increasing without a known cure, resulting in an increasing number of informal caregivers. Caring for a person with dementia results in increased stress and depressive symptoms. There are several behavioural interventions designed to alleviate stress and depressive symptoms in caregivers of persons with dementia with evidence of efficacy. Two of the best-known interventions are the New York University Caregiver Intervention (NYUCI) and the Resources for Enhancing Alzheimer's Caregivers Health (REACH). The effectiveness of the NYUCI and REACH has never been compared. There is also a paucity of data on which interventions are more effective in Hispanics in New York City. Thus, we proposed the Northern Manhattan Hispanic Caregiver intervention Effectiveness Study (NHiCE), a pragmatic clinical trial designed to compare the effectiveness of adaptations of the NYUCI and the REACH in informal Hispanic caregivers of persons with dementia in New York City.
  
  
  
  NHiCE is a 6-month randomised controlled trial comparing the effectiveness of adaptations of the NYUCI and REACH among 200 Hispanic informal adult caregivers of persons with dementia. The planned number of sessions of the NYUCI and REACH are similar. The primary outcome measures are changes from baseline to 6 months in the Zarit Caregiver Burden Scale and Geriatric Depression Scale. Our primary approach to analyses will be intent-to-treat. The primary analyses will use mixed random effects models, and a full information maximum likelihood approach, with sensitivity analyses using generalised estimating equation.
  
  
  
  NHiCE is approved by the Institutional Review Board of Columbia University Medical Center (protocol AAAM5150). A Data Safety Monitoring Board monitors the progress of the study. Dissemination will include reports of the characteristics of the study participants, as well as a report of the results of the clinical trial.
  
  
  
  NCT02092987, Pre-results.
authors.affiliation: Departments of Medicine and Epidemiology, Columbia University Medical Center, New York, New York, USA.
authors.forename: José A
authors.initials: JA
authors.lastname: Luchsinger
authors.affiliation: Burgio Geriatric Consulting, Tuscaloosa, Alabama, USA.
authors.forename: Louis
authors.initials: L
authors.lastname: Burgio
authors.affiliation: Departments of Psychiatry and Rehabilitation Medicine, New York University School of Medicine, New York, New York, USA.
authors.forename: Mary
authors.initials: M
authors.lastname: Mittelman
authors.affiliation: Riverstone Senior Life Services, New York, New York, USA.
authors.forename: Ilana
authors.initials: I
authors.lastname: Dunner
authors.affiliation: CaringKind, New York, New York, USA.
authors.forename: Jed A
authors.initials: JA
authors.lastname: Levine
authors.affiliation: Research Division, Hebrew Home at Riverdale, Bronx, New York, USA.|Weill Cornell Medical College, New York, New York, USA.
authors.forename: Jian
authors.initials: J
authors.lastname: Kong
authors.affiliation: Research Division, Hebrew Home at Riverdale, Bronx, New York, USA.|Weill Cornell Medical College, New York, New York, USA.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Silver
authors.affiliation: Research Division, Hebrew Home at Riverdale, Bronx, New York, USA.|Weill Cornell Medical College, New York, New York, USA.
authors.forename: Mildred
authors.initials: M
authors.lastname: Ramirez
authors.affiliation: Research Division, Hebrew Home at Riverdale, Bronx, New York, USA.|Weill Cornell Medical College, New York, New York, USA.
authors.forename: Jeanne A
authors.initials: JA
authors.lastname: Teresi
mesh_terms: D000223:Adaptation, Psychological; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017028:Caregivers / Q000523:psychology*; D003362:Cost-Benefit Analysis; D003704:Dementia / Q000451:nursing*; D003863:Depression / Q000628:therapy*; D005260:Female; D006630:Hispanic or Latino / Q000706:statistics & numerical data; D006801:Humans; D016013:Likelihood Functions; D008297:Male; D008875:Middle Aged; D009519:New York City; D011569:Psychiatric Status Rating Scales; D011613:Psychotherapy / Q000379:methods*; D011788:Quality of Life; D012107:Research Design; D012944:Social Support; D055815:Young Adult
keywords: Alzheimer; caregiving