title: Single-center experience with vascular closure devices in real-world endovascular peripheral interventions.
abstract: BACKGROUND
  The aim of the current study was to evaluate the efficacy and safety of vascular closure devices (VCDs) in non-cardiac endovascular interventions.
  
  
  METHODS
  Retrospective analysis of consecutive patients submitted to endovascular interventions, with deployment of 2327 vascular closure devices. Demographic, clinical/periprocedural, post-operative, complication and reintervention data were reviewed.
  
  
  RESULTS
  A total of 2107 patients (1409 [66.9%] men) were included. Perclose ProGlide® (Abbott Vascular) was employed 1683 times (72.3%), Angio-Seal™ (St. Jude Medical Inc.) 463 (19.9%) and 181 (7.8%) Exoseal® (Cordis). Patients were 70.4±11 years old. Of all vascular approaches, 1794 were retrograde (77.1%) and 533 antegrade (22.9%), with sheath size ranging from 5 to 8 French. Overall success rate was 95.2% and did not significantly vary according to the device. Overall failure rate was 4.8%, with high puncture site, morbid obesity, previous total anticoagulation and severe calcification being related to worse efficiency results. Major complications occurred in 15 patients (0.6%). All patients were evaluated before discharge from the hospital, and were scheduled to return for ambulatory follow-up visits at 30 days postoperatively. Control duplex ultrasonography was performed on a regular basis, or within this period in case of clinical complain/signs.
  
  
  CONCLUSIONS
  Vascular closure devices proved to be safe and effective in this study. Additional prospective randomized studies are recommended.
authors.affiliation: Division of Interventional Angiology, Leipzig University Hospital, Leipzig, Germany - brunofreitas@saudevascular.com.
authors.forename: Bruno
authors.initials: B
authors.lastname: Freitas
authors.affiliation: Division of Interventional Angiology, Leipzig University Hospital, Leipzig, Germany.
authors.forename: Sabine
authors.initials: S
authors.lastname: Steiner
authors.affiliation: Division of Interventional Angiology, Leipzig University Hospital, Leipzig, Germany.
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Bausback
authors.affiliation: Division of Interventional Angiology, Leipzig University Hospital, Leipzig, Germany.
authors.forename: Holger
authors.initials: H
authors.lastname: Staab
authors.affiliation: Division of Interventional Angiology, Leipzig University Hospital, Leipzig, Germany.
authors.forename: Daniela
authors.initials: D
authors.lastname: Branzan
authors.affiliation: Division of Interventional Angiology, Leipzig University Hospital, Leipzig, Germany.
authors.forename: Ursula
authors.initials: U
authors.lastname: Banning-Eichenseer
authors.affiliation: Division of Interventional Angiology, Leipzig University Hospital, Leipzig, Germany.
authors.forename: Andrej
authors.initials: A
authors.lastname: Schmidt
authors.affiliation: Division of Interventional Angiology, Leipzig University Hospital, Leipzig, Germany.
authors.forename: Dierk
authors.initials: D
authors.lastname: Scheinert
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000792:Angiography; D016063:Blood Loss, Surgical / Q000517:prevention & control*; D057510:Endovascular Procedures / Q000009:adverse effects; D004867:Equipment Design; D005260:Female; D005858:Germany; D006489:Hemostatic Techniques / Q000009:adverse effects / Q000295:instrumentation*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016491:Peripheral Vascular Diseases / Q000000981:diagnostic imaging / Q000601:surgery*; D019106:Postoperative Hemorrhage / Q000000981:diagnostic imaging / Q000209:etiology / Q000517:prevention & control*; D011677:Punctures; D012189:Retrospective Studies; D012307:Risk Factors; D018616:Ultrasonography, Doppler, Duplex; D065506:Vascular Closure Devices