title: Hemodialysis Decreases the Etiologically-Related Early Vascular Aging Observed in End-Stage Renal Disease: A 5-Year Follow-Up Study.
abstract: OBJECTIVE
  To analyze the early vascular aging (EVA) in end-stage renal disease (ESRD) patients, attempting to determine a potential association between EVA and the etiology of ESRD, and to investigate the association of hemodialysis and EVA in ESRD patients during a 5-year follow-up period.
  
  
  METHODS
  Carotid-femoral pulse wave velocity (cfPWV) was obtained in 151 chronically hemodialyzed patients (CHP) and 283 control subjects, and in 25 CHP, who were followed-up after a 5-year lapse.
  
  
  RESULTS
  cfPWV increased in ESRD patients compared to control subjects. The cfPWV-age relationship was found to have a steeper increase in ESRD patients. The highest cfPWV and EVA values were observed in patients with diabetic nephropathy. Regression analysis demonstrated a significant reduction of the EVA in HD patients on a 5-year follow-up.
  
  
  CONCLUSIONS
  Patients in ESRD showed higher levels of EVA. cfPWV and EVA differed in ESRD patients depending on their renal failure etiology. CHP showed an EVA reduction after a 5-year follow-up period.
authors.affiliation: Physiology Department, School of Medicine, Centro Universitario de Investigación, Innovación y Diagnóstico Arterial (CUiiDARTE), Republic University, Montevideo, Uruguay.
authors.forename: Daniel
authors.initials: D
authors.lastname: Bia
authors.forename: Cintia
authors.initials: C
authors.lastname: Galli
authors.forename: Yanina
authors.initials: Y
authors.lastname: Zócalo
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Valtuille
authors.forename: Sandra
authors.initials: S
authors.lastname: Wray
authors.forename: Ricardo
authors.initials: R
authors.lastname: Armentano
authors.forename: Edmundo
authors.initials: E
authors.lastname: Cabrera-Fischer
mesh_terms: D000375:Aging; D002339:Carotid Arteries / Q000503:physiopathology; D016022:Case-Control Studies; D005263:Femoral Artery / Q000503:physiopathology; D005500:Follow-Up Studies; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000628:therapy*; D063177:Pulse Wave Analysis / Q000379:methods; D006435:Renal Dialysis