title: Novel Ti-Ta-Hf-Zr alloys with promising mechanical properties for prospective stent applications.
abstract: Titanium alloys are receiving increasing research interest for the development of metallic stent materials due to their excellent biocompatibility, corrosion resistance, non-magnetism and radiopacity. In this study, a new series of Ti-Ta-Hf-Zr (TTHZ) alloys including Ti-37Ta-26Hf-13Zr, Ti-40Ta-22Hf-11.7Zr and Ti-45Ta-18.4Hf-10Zr (wt.%) were designed using the d-electron theory combined with electron to atom ratio (e/a) and molybdenum equivalence (Moeq) approaches. The microstructure of the TTHZ alloys were investigated using optical microscopy, XRD, SEM and TEM and the mechanical properties were tested using a Vickers micro-indenter, compression and tensile testing machines. The cytocompatibility of the alloys was assessed using osteoblast-like cells in vitro. The as-cast TTHZ alloys consisted of primarily β and ω nanoparticles and their tensile strength, yield strength, Young's modulus and elastic admissible strain were measured as being between 1000.7-1172.8 MPa, 1000.7-1132.2 MPa, 71.7-79.1 GPa and 1.32-1.58%, respectively. The compressive yield strength of the as-cast alloys ranged from 1137.0 to 1158.0 MPa. The TTHZ alloys exhibited excellent cytocompatibility as indicated by their high cell viability ratios, which were close to that of CP-Ti. The TTHZ alloys can be anticipated to be promising metallic stent materials by virtue of the unique combination of extraordinarily high elastic admissible strain, high mechanical strength and excellent biocompatibility.
authors.affiliation: College of Materials Science and Engineering, Jilin University, Jilin 130025, China.|Advanced Material Research and Development Center, Zhejiang Industry &Trade Vocational College, Zhejiang 325003, China.
authors.forename: Jixing
authors.initials: J
authors.lastname: Lin
authors.affiliation: Department of Mechanical Engineering, Bozok University, Yozgat 66100, Turkey.
authors.forename: Sertan
authors.initials: S
authors.lastname: Ozan
authors.affiliation: School of Engineering, RMIT University, Victoria 3083, Australia.
authors.forename: Yuncang
authors.initials: Y
authors.lastname: Li
authors.affiliation: National Institute for Materials Science, Tsukuba 3050047, Japan.
authors.forename: Dehai
authors.initials: D
authors.lastname: Ping
authors.affiliation: Advanced Material Research and Development Center, Zhejiang Industry &Trade Vocational College, Zhejiang 325003, China.
authors.forename: Xian
authors.initials: X
authors.lastname: Tong
authors.affiliation: College of Materials Science and Engineering, Jilin University, Jilin 130025, China.
authors.forename: Guangyu
authors.initials: G
authors.lastname: Li
authors.affiliation: School of Engineering, RMIT University, Victoria 3083, Australia.
authors.forename: Cuie
authors.initials: C
authors.lastname: Wen
mesh_terms: D000497:Alloys / Q000737:chemistry*; D001672:Biocompatible Materials / Q000737:chemistry; D002460:Cell Line; D019245:Compressive Strength; D055119:Elastic Modulus; D006801:Humans; D008422:Materials Testing; D008853:Microscopy; D015607:Stents; D013718:Tensile Strength; D028561:Transition Elements / Q000737:chemistry*
chemical_list: D000497:Alloys; D001672:Biocompatible Materials; D028561:Transition Elements