title: Leptin/OB-R signaling is elevated in mice with Sjögren's syndrome and is implicated in disease pathogenesis.
abstract: Sjögren's syndrome (SjS) is a systemic autoimmune disease resulting in a severe dry mouth and dry eyes. Currently, care for patients with SjS is palliative, as no established therapeutics target the disease directly, and its pathogenetic mechanisms are uncertain. Leptin activates B cells to induce the secretion of proinflammatory and anti-inflammatory cytokines and is elevated in several autoimmune diseases. In this study, we found the expression of leptin and its receptor OB-R in mouse models of SjS are elevated both locally and systemically during SjS progression. Recombinant serotype 2 adeno-associated viral (rAAV2) vectors expressing either OB-R shRNA (rAAV2-shOB-R) or none (rAAV2-null) were injected into 4 or 16 week-old BALB/c NOD/LtJ (NOD) mice and resulted in a modest reduction in glandular inflammation in the SjS model. In conclusion, Leptin/OB-R signaling may be pathogenically involved in SjS and may serve as a new marker and a potential therapeutic target.
authors.affiliation: Department of Rheumatology and Immunology, The Third Affiliated Hospital of Soochow University, Jiangsu, Changzhou, 213003, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Xu
authors.affiliation: Department of Rheumatology and Immunology, The Third Affiliated Hospital of Soochow University, Jiangsu, Changzhou, 213003, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Xie
authors.affiliation: Department of Rheumatology and Immunology, The Third Affiliated Hospital of Soochow University, Jiangsu, Changzhou, 213003, China.
authors.forename: Yingchun
authors.initials: Y
authors.lastname: Ma
authors.affiliation: Department of Rheumatology and Immunology, The Third Affiliated Hospital of Soochow University, Jiangsu, Changzhou, 213003, China.
authors.forename: Shiliang
authors.initials: S
authors.lastname: Zhou
authors.affiliation: Department of Rheumatology and Immunology, The Third Affiliated Hospital of Soochow University, Jiangsu, Changzhou, 213003, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Rheumatology and Immunology, The Third Affiliated Hospital of Soochow University, Jiangsu, Changzhou, 213003, China.
authors.forename: Jinyun
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Rheumatology and Immunology, The Third Affiliated Hospital of Soochow University, Jiangsu, Changzhou, 213003, China.
authors.forename: Mingyuan
authors.initials: M
authors.lastname: Cai
authors.affiliation: Department of Rheumatology and Immunology, The Third Affiliated Hospital of Soochow University, Jiangsu, Changzhou, 213003, China.
authors.forename: Rurong
authors.initials: R
authors.lastname: Sun
authors.affiliation: Department of Rheumatology and Immunology, The Third Affiliated Hospital of Soochow University, Jiangsu, Changzhou, 213003, China.
authors.forename: Peirong
authors.initials: P
authors.lastname: Zhang
authors.affiliation: Department of Rheumatology and Immunology, The Third Affiliated Hospital of Soochow University, Jiangsu, Changzhou, 213003, China.
authors.forename: Shaobo
authors.initials: S
authors.lastname: Yu
authors.affiliation: Department of Rheumatology and Immunology, The Third Affiliated Hospital of Soochow University, Jiangsu, Changzhou, 213003, China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Xu
authors.affiliation: Department of Rheumatology and Immunology, The Third Affiliated Hospital of Soochow University, Jiangsu, Changzhou, 213003, China.
authors.forename: Wanlan
authors.initials: W
authors.lastname: Jiang
authors.affiliation: Department of Rheumatology and Immunology, The Third Affiliated Hospital of Soochow University, Jiangsu, Changzhou, 213003, China. Electronic address: wuumin_2016@163.com.
authors.forename: Min
authors.initials: M
authors.lastname: Wu
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D007249:Inflammation / Q000235:genetics / Q000473:pathology; D020738:Leptin / Q000032:analysis / Q000235:genetics*; D051379:Mice; D008807:Mice, Inbred BALB C; D016688:Mice, Inbred NOD; D054411:Receptors, Leptin / Q000032:analysis / Q000235:genetics*; D015398:Signal Transduction; D012859:Sjogren's Syndrome / Q000235:genetics* / Q000473:pathology; D015854:Up-Regulation
chemical_list: D020738:Leptin; D054411:Receptors, Leptin
keywords: B lymphocyte; Leptin; Leptin receptor (OB-R); Sjögren's syndrome (SjS)