title: The association between the TP53 Arg72Pro polymorphism and colorectal cancer: An updated meta-analysis based on 32 studies.
abstract: Several previous studies evaluated the association between the Arg72Pro (rs1042522) polymorphism in the TP53 tumor suppressor gene and colorectal cancer (CRC). However, the results are conflicting. This meta-analysis aimed to shed new light on the precise association between TP53 variants and CRC. We analyzed 32 published case-control studies involving 8,586 cases and 10,275 controls using crude odd ratios (ORs) with 95% confidence intervals (CIs). The meta-analysis was performed using a fixed-effect or random-effects model, as appropriate. We found that the TP53 Arg72Pro polymorphism was not significantly associated with CRC risk in the overall population. However, subgroup analysis based on ethnicity revealed an increased risk of CRC among Asians (CC vs. GC+GG: OR=1.22, 95% CI: 1.02-1.45), and similar results were found for rectal cancer (CC vs. GC+GG: OR=1.34, 95% CI: 1.120-1.62). These results suggest that the TP53 Arg72Pro polymorphism CC genotype may contribute to an increased risk of CRC, especially for rectal cancer and among Asians.
authors.affiliation: Molecular Oncology Laboratory of Cancer Research Institute, The First Affiliated Hospital of China Medical University, Shenyang, 110001, PR China.
authors.forename: Xin
authors.initials: X
authors.lastname: Tian
authors.affiliation: Department of Pathology, The First Affiliated Hospital and College of Basic Medical Sciences of China Medical University, Shenyang, 110001, PR China.|Institute of Pathology and Pathophysiology, Shenyang, 110001, PR China.
authors.forename: Shundong
authors.initials: S
authors.lastname: Dai
authors.affiliation: Department of Immunology and Biotherapy, Liaoning Cancer Hospital and Institute, Shenyang, 110042, PR China.
authors.forename: Jing
authors.initials: J
authors.lastname: Sun
authors.affiliation: Department of Rheumatology, The First Affiliated Hospital of China Medical University, Shenyang, 110001, PR China.
authors.forename: Shenyi
authors.initials: S
authors.lastname: Jiang
authors.affiliation: Molecular Oncology Laboratory of Cancer Research Institute, The First Affiliated Hospital of China Medical University, Shenyang, 110001, PR China.
authors.forename: Youhong
authors.initials: Y
authors.lastname: Jiang
mesh_terms: D000483:Alleles; D019943:Amino Acid Substitution; D003062:Codon; D015179:Colorectal Neoplasms / Q000235:genetics*; D005838:Genotype; D006801:Humans; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D017594:Publication Bias; D012306:Risk; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
chemical_list: D003062:Codon; D016159:Tumor Suppressor Protein p53
keywords: TP53; colorectal cancer; meta-analysis; polymorphism