title: Role of inflammation in obesity-related breast cancer.
abstract: Chronic inflammation associated with obesity is now recognized to be an important condition in promoting carcinogenesis and progression in breast cancer patients, mostly in postmenopausal women with tumors expressing estrogen and progesterone receptors. In obese patients, altered levels of several inflammatory mediators regulating aromatase and estrogen expression are one of the mechanisms responsible of increase breast cancer risk. Growing attention has also been paid to the local adipose inflammation and the role played by macrophages as determinants of breast cancer risk recurrence and prognosis. The inflammation-obesity axis offers different molecular signaling pathways for therapeutic interventions and potential pharmacological targets. The increasing rate of obesity worldwide associated with the recent findings linking inflammation and breast cancer urge further investigation.
authors.affiliation: Oncology Experimental Therapeutics, IRCCS Humanitas Clinical and Research Center, Rozzano, Milan, Italy.
authors.forename: Elisa
authors.initials: E
authors.lastname: Crespi
authors.affiliation: Oncology Experimental Therapeutics, IRCCS Humanitas Clinical and Research Center, Rozzano, Milan, Italy.
authors.forename: Giulia
authors.initials: G
authors.lastname: Bottai
authors.affiliation: Oncology Experimental Therapeutics, IRCCS Humanitas Clinical and Research Center, Rozzano, Milan, Italy. Electronic address: libero.santarpia@humanitasresearch.it.
authors.forename: Libero
authors.initials: L
authors.lastname: Santarpia
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D002908:Chronic Disease; D018450:Disease Progression; D015195:Drug Design; D004967:Estrogens / Q000378:metabolism; D005260:Female; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000209:etiology / Q000473:pathology*; D018836:Inflammation Mediators / Q000378:metabolism; D008264:Macrophages / Q000378:metabolism; D009765:Obesity / Q000150:complications*; D011980:Receptors, Progesterone / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D004967:Estrogens; D018836:Inflammation Mediators; D011980:Receptors, Progesterone