title: Data comparing the kinetics of procollagen type I processing by bone morphogenetic protein 1 (BMP-1) with and without procollagen C-proteinase enhancer 1 (PCPE-1).
abstract: This article provides kinetic constants for C-terminal processing of procollagen type I by bone morphogenetic protein 1 (BMP-1; the major procollagen C-proteinase), a reaction stimulated by the connective tissue glycoprotein procollagen C-proteinase enhancer 1 (PCPE-1). Reported areKm,Vmax,KcatandKcat/Km(catalytic coefficient) values for BMP-1 alone, BMP-1 with intact PCPE-1, BMP-1 with the CUB (Complement C1r/C1s, Uegf, BMP-1) domains fragment of PCPE-1 as well as its NTR (netrin-like) domain.
authors.affiliation: Maurice and Gabriela Goldschleger Eye Research Institute, Tel-Aviv University Sackler Faculty of Medicine, Sheba Medical Center, Tel-Hashomer 52621, Israel.
authors.forename: Laura
authors.initials: L
authors.lastname: Moschcovich
authors.affiliation: Maurice and Gabriela Goldschleger Eye Research Institute, Tel-Aviv University Sackler Faculty of Medicine, Sheba Medical Center, Tel-Hashomer 52621, Israel.
authors.forename: Efrat
authors.initials: E
authors.lastname: Kessler
keywords: Bone morphogenetic protein 1; Collagen biology; Enzyme kinetics; Extracellular matrix; Procollagen C-proteinase; Procollagen C-proteinase enhancer; Proteolytic processing