title: Effects of hepatitis B vaccine boosters on anti-HBs-negative children after primary immunization.
abstract: This study was aimed at evaluating the changes of hepatitis B surface antibody (anti-HBs) titer after booster vaccinations in 5-15-year-old children with negative antibodies (<10 mIU/mL). 225 subjects (mean age, 9.28 ± 2.95 years) included in the study consisted of 123 males and 102 females, with a complete hepatitis B vaccination during infancy. The participants were divided into 3 groups according to their pre-booster anti-HBs level: Group I, <0.1 mIU/mL; Group II, 0.1 to <1.0 mIU/mL; Group III, 1.0 to <10.0 mIU/mL. All the participants were administered 3 doses of booster hepatitis B vaccination (0-1-6 month, 20 µg), and changes in the levels of antibodies were examined at 4 time-points (one month after the first and the third dose, one year and 5 years after the third dose). The seroprotective rate (defined as anti-HBs ≥10.0 mIU/mL) among 225 subjects at the 4 time-points were 93.8%, 100%, 83.6% and 73.4%, respectively (χ2= 90.29, p < 0.05). The seroprotective rate (≥10 mIU/mL) and anti-HBs geometric mean titer (GMT) in Group III were always higher than those in the other 2 groups (all p < 0.05). The immune effect of a 3 -dose booster revaccination is good, and the booster-induced immune response was correlated with the pre-booster titer level, and ≥1.0 mIU/mL ensuring a robust positive response, whereas titers below this value may indicate the need for a course of booster vaccination.
authors.affiliation: a School of Medicine, Ningbo University , Ningbo , China.
authors.forename: Shunshun
authors.initials: S
authors.lastname: Lu
authors.affiliation: b State Key Laboratory for Diagnosis and Treatment of Infectious Disease, Key Laboratory of Infectious Diseases , the First Affiliated Hospital, School of Medicine, Zhejiang University , Hangzhou , China.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Ren
authors.affiliation: c Zhejiang Provincial Center for Disease Control and Prevention , Hangzhou , Zhejiang , China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Li
authors.affiliation: c Zhejiang Provincial Center for Disease Control and Prevention , Hangzhou , Zhejiang , China.
authors.forename: Zhenggang
authors.initials: Z
authors.lastname: Jiang
authors.affiliation: c Zhejiang Provincial Center for Disease Control and Prevention , Hangzhou , Zhejiang , China.
authors.forename: Yongdi
authors.initials: Y
authors.lastname: Chen
authors.affiliation: b State Key Laboratory for Diagnosis and Treatment of Infectious Disease, Key Laboratory of Infectious Diseases , the First Affiliated Hospital, School of Medicine, Zhejiang University , Hangzhou , China.
authors.forename: Kaijin
authors.initials: K
authors.lastname: Xu
authors.affiliation: b State Key Laboratory for Diagnosis and Treatment of Infectious Disease, Key Laboratory of Infectious Diseases , the First Affiliated Hospital, School of Medicine, Zhejiang University , Hangzhou , China.
authors.forename: Bing
authors.initials: B
authors.lastname: Ruan
authors.affiliation: b State Key Laboratory for Diagnosis and Treatment of Infectious Disease, Key Laboratory of Infectious Diseases , the First Affiliated Hospital, School of Medicine, Zhejiang University , Hangzhou , China.
authors.forename: Shigui
authors.initials: S
authors.lastname: Yang
authors.affiliation: b State Key Laboratory for Diagnosis and Treatment of Infectious Disease, Key Laboratory of Infectious Diseases , the First Affiliated Hospital, School of Medicine, Zhejiang University , Hangzhou , China.
authors.forename: Tiansheng
authors.initials: T
authors.lastname: Xie
authors.affiliation: a School of Medicine, Ningbo University , Ningbo , China.
authors.forename: Linna
authors.initials: L
authors.lastname: Yang
authors.affiliation: d Zhejiang Provincial Hospital , Hangzhou , Zhejiang , China.
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.affiliation: c Zhejiang Provincial Center for Disease Control and Prevention , Hangzhou , Zhejiang , China.
authors.forename: Jun
authors.initials: J
authors.lastname: Yao
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006510:Hepatitis B Antibodies / Q000097:blood*; D006514:Hepatitis B Surface Antigens / Q000276:immunology; D017325:Hepatitis B Vaccines / Q000008:administration & dosage* / Q000276:immunology*; D006801:Humans; D007117:Immunization, Secondary; D008297:Male; D016896:Treatment Outcome
chemical_list: D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines
keywords: 5-year follow-up; HBV; anti-HBs; booster vaccination; immunogenicity effect