title: Effect of pioglitazone on nerve conduction velocity of the median nerve in the carpal tunnel in type 2 diabetes patients.
abstract: OBJECTIVE
  To evaluate the impact of pioglitazone pharmacotherapy in median nerve electrophysiology in the carpal tunnel among type 2 diabetes patients.
  
  
  METHODS
  The study was executed in patients with type 2 diabetes, treated with oral drugs, categorized under pioglitazone or non-pioglitazone group (14 in each group), and who received electrophysiological evaluation by nerve conduction velocity at baseline and 3 mo.
  
  
  RESULTS
  At 3 mo, pioglitazone-category had inferior amplitude in sensory median nerve [8.5 interquartile range (IQR) = 6.5 to 11.5)vsnon-pioglitazone 14.5 (IQR 10.5 to 18.75)] (P= 0.002). Non-pioglitazone category displayed amelioration in amplitude in the sensory median nerve [baseline 13 (IQR = 9 to 16.25)vs3 mo 8.5 (IQR = 6.5 to 11.5)] (P= 0.01) and amplitude in motor median nerve [baseline 9 (IQR = 4.75 to 11)vs3 mo 6.75 (IQR = 4.75 to 10.25)] (P= 0.049); and deterioration of terminal latency of in motor ulnar nerve [baseline 2.07 (IQR = 1.92 to 2.25)vs3 mo 2.16 (IQR = 1.97 to 2.325)] (P= 0.043). There was amelioration of terminal latency in sensory ulnar nerve [baseline 2.45 (IQR = 2.315 to 2.88)vs3 mo 2.37 (IQR = 2.275 to 2.445) for pioglitazone group (P= 0.038).
  
  
  CONCLUSIONS
  Treatment with pioglitazone accentuates probability of compressive neuropathy. In spite of comparable glycemic control over 3 mo, patients treated with pioglitazone showed superior electrophysiological parameters for the ulnar nerve. Pioglitazone has favourable outcome in nerve electrophysiology which was repealed when the nerve was subjected to compressive neuropathy.
authors.affiliation: Sudip Chatterjee, Mili Bandyopadhyay, Department of Medicine, Vivekananda Institute of Medical Sciences, Ramakrishna Mission Seva Pratishthan, Kolkata 700026, West Bengal, India.
authors.forename: Sudip
authors.initials: S
authors.lastname: Chatterjee
authors.affiliation: Sudip Chatterjee, Mili Bandyopadhyay, Department of Medicine, Vivekananda Institute of Medical Sciences, Ramakrishna Mission Seva Pratishthan, Kolkata 700026, West Bengal, India.
authors.forename: Debmalya
authors.initials: D
authors.lastname: Sanyal
authors.affiliation: Sudip Chatterjee, Mili Bandyopadhyay, Department of Medicine, Vivekananda Institute of Medical Sciences, Ramakrishna Mission Seva Pratishthan, Kolkata 700026, West Bengal, India.
authors.forename: Sourav
authors.initials: S
authors.lastname: Das Choudhury
authors.affiliation: Sudip Chatterjee, Mili Bandyopadhyay, Department of Medicine, Vivekananda Institute of Medical Sciences, Ramakrishna Mission Seva Pratishthan, Kolkata 700026, West Bengal, India.
authors.forename: Mili
authors.initials: M
authors.lastname: Bandyopadhyay
authors.affiliation: Sudip Chatterjee, Mili Bandyopadhyay, Department of Medicine, Vivekananda Institute of Medical Sciences, Ramakrishna Mission Seva Pratishthan, Kolkata 700026, West Bengal, India.
authors.forename: Suraj
authors.initials: S
authors.lastname: Chakraborty
authors.affiliation: Sudip Chatterjee, Mili Bandyopadhyay, Department of Medicine, Vivekananda Institute of Medical Sciences, Ramakrishna Mission Seva Pratishthan, Kolkata 700026, West Bengal, India.
authors.forename: Arabinda
authors.initials: A
authors.lastname: Mukherjee
keywords: Adipocytes; Carpal tunnel; Diabetes mellitus; Neuropathy; Pioglitazone