title: Shear-Wave Elastography for the Differential Diagnosis of Breast Papillary Lesions.
abstract: OBJECTIVE
  To evaluate the diagnostic performance of shear-wave elastography (SWE) for the differential diagnosis of breast papillary lesions.
  
  
  METHODS
  This study was an institutional review board-approved retrospective study, with a waiver of informed consent. A total of 79 breast papillary lesions in 71 consecutive women underwent ultrasound and SWE prior to biopsy. Ultrasound features and quantitative SWE parameters were recorded for each lesion. All lesions were surgically excised or excised using an ultrasound-guided vacuum-assisted method. The diagnostic performances of the quantitative SWE parameters were compared using the area under the receiver operating characteristic curve (AUC).
  
  
  RESULTS
  Of the 79 lesions, six (7.6%) were malignant and 12 (15.2%) were atypical. Orientation, margin, and the final BI-RADS ultrasound assessments were significantly different for the papillary lesions (p < 0.05). All qualitative SWE parameters were significantly different (p < 0.05). The AUC values for SWE parameters of benign and atypical or malignant papillary lesions ranged from 0.707 to 0.757 (sensitivity, 44.4-94.4%; specificity, 42.6-88.5%). The maximum elasticity and the mean elasticity showed the highest AUC (0.757) to differentiate papillary lesions.
  
  
  CONCLUSIONS
  SWE provides additional information for the differential diagnosis of breast papillary lesions. Quantitative SWE features were helpful to differentiate breast papillary lesions.
authors.affiliation: Department of Radiology, Ewha Womans University, College of Medicine, Seoul, Republic of Korea.|Department of Radiology, Yonsei University, College of Medicine, Seoul, Republic of Korea.
authors.forename: Jin
authors.initials: J
authors.lastname: Chung
authors.affiliation: Department of Radiology, Ewha Womans University, College of Medicine, Seoul, Republic of Korea.
authors.forename: Won Kyung
authors.initials: WK
authors.lastname: Lee
authors.affiliation: Department of Radiology, Ewha Womans University, College of Medicine, Seoul, Republic of Korea.
authors.forename: Eun-Suk
authors.initials: ES
authors.lastname: Cha
authors.affiliation: Department of Radiology, Ewha Womans University, College of Medicine, Seoul, Republic of Korea.
authors.forename: Jee Eun
authors.initials: JE
authors.lastname: Lee
authors.affiliation: Department of Radiology, Ewha Womans University, College of Medicine, Seoul, Republic of Korea.
authors.forename: Jeoung Hyun
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Department of Nuclear Medicine, Yonsei University, College of Medicine, Seoul, Republic of Korea.
authors.forename: Young Hoon
authors.initials: YH
authors.lastname: Ryu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging; D002291:Carcinoma, Papillary / Q000175:diagnosis* / Q000000981:diagnostic imaging; D054459:Elasticity Imaging Techniques / Q000379:methods*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008875:Middle Aged; D012372:ROC Curve; D015203:Reproducibility of Results; D012189:Retrospective Studies; D016217:Ultrasonography, Mammary / Q000379:methods*; D055815:Young Adult