title: Myostatin serum concentrations are correlated with the severity of knee osteoarthritis.
abstract: OBJECTIVE
  Myostatin, a member of the transforming growth factor-β family, contributes to joint deterioration in mice. Thus, we aimed to assess the correlation of myostatin concentrations with the presence and severity of knee osteoarthritis (OA).
  
  
  METHODS
  We determined serum and synovial fluid (SF) myostatin concentrations in a population of 184 patients with knee OA and 109 healthy controls.
  
  
  RESULTS
  The knee OA group presented with higher serum myostatin concentrations than the controls. Knee OA patients with KL grade 4 showed higher serum and SF myostatin concentrations compared with those with KL grade 2 and 3. Knee OA patients with KL grade 3 had higher serum and SF myostatin concentrations compared with those with KL grade 2. Serum and SF myostatin concentrations were significantly correlated with KL grading.
  
  
  CONCLUSIONS
  Serum and SF myostatin concentrations were correlated with the presence and severity of knee OA.
authors.affiliation: Department of Orthopedics, Academy of Orthopedics of Guangdong Province, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.
authors.forename: Chang
authors.initials: C
authors.lastname: Zhao
authors.affiliation: Department of Orthopedics, Academy of Orthopedics of Guangdong Province, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Shao
authors.affiliation: Department of Orthopedics, Academy of Orthopedics of Guangdong Province, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.
authors.forename: Chuangxin
authors.initials: C
authors.lastname: Lin
authors.affiliation: Department of Orthopedics, Academy of Orthopedics of Guangdong Province, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.
authors.forename: Chun
authors.initials: C
authors.lastname: Zeng
authors.affiliation: Department of Orthopedics, Academy of Orthopedics of Guangdong Province, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.
authors.forename: Hang
authors.initials: H
authors.lastname: Fang
authors.affiliation: Department of Orthopedics, Academy of Orthopedics of Guangdong Province, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.
authors.forename: Jianying
authors.initials: J
authors.lastname: Pan
authors.affiliation: Department of Orthopedics, Academy of Orthopedics of Guangdong Province, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.
authors.forename: Daozhang
authors.initials: D
authors.lastname: Cai
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000032:analysis / Q000097:blood / Q000737:chemistry; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D055435:Myostatin / Q000032:analysis* / Q000097:blood / Q000737:chemistry; D020370:Osteoarthritis, Knee / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology / Q000378:metabolism; D012720:Severity of Illness Index; D013582:Synovial Fluid / Q000737:chemistry
chemical_list: D015415:Biomarkers; C525911:MSTN protein, human; D055435:Myostatin
keywords: myostatin; osteoarthritis; severity