title: Can acetazolamide be used to treat diseases involving increased bone mineral density?
abstract: Sclerosing bone dysplasias are a series of clinically and genetically heterogeneous diseases characterized by functional failure of the osteoclasts in bone resorption, leading to an excessive amount of bone mineral density (BMD) which could have serious clinical consequences. We treated three children affected with seriously high levels of BMD with acetazolamide, with the intention of inducing metabolic acidosis, thus increasing bone resorption and reducing BMD. All our patients tolerated and followed the treatment well and the clinical response was satisfactory in all cases.
authors.affiliation: Paediatric Nephrology Unit, Department of Pediatrics, Santa Lucía General University Hospital, Cartagena, Spain.
authors.forename: Juan David
authors.initials: JD
authors.lastname: González-Rodríguez
authors.affiliation: Paediatric Nephrology Unit, Department of Pediatrics, Nuestra Señora de Candelaria University Hospital, Tenerife, Spain.
authors.forename: María Isabel
authors.initials: MI
authors.lastname: Luis-Yanes
authors.affiliation: Paediatric Nephrology Unit, Department of Pediatrics, Santa Lucía General University Hospital, Cartagena, Spain.
authors.forename: Esther
authors.initials: E
authors.lastname: Inglés-Torres
authors.affiliation: Paediatric Nephrology Unit, Department of Pediatrics, Nuestra Señora de Candelaria University Hospital, Tenerife, Spain.
authors.forename: Pedro
authors.initials: P
authors.lastname: Arango-Sancho
authors.affiliation: Paediatric Nephrology Unit, Department of Pediatrics, Santa Lucía General University Hospital, Cartagena, Spain.
authors.forename: José Eugenio
authors.initials: JE
authors.lastname: Cabrera-Sevilla
authors.affiliation: Paediatric Nephrology Unit, Department of Pediatrics, Nuestra Señora de Candelaria University Hospital, Tenerife, Spain.
authors.forename: María Rosario
authors.initials: MR
authors.lastname: Duque-Fernández
authors.affiliation: Paediatric Nephrology Unit, Department of Pediatrics, Santa Lucía General University Hospital, Cartagena, Spain.
authors.forename: Salvador
authors.initials: S
authors.lastname: Gil-Sánchez
authors.affiliation: Paediatric Nephrology Unit, Department of Pediatrics, Nuestra Señora de Candelaria University Hospital, Tenerife, Spain.
authors.forename: Víctor Manuel
authors.initials: VM
authors.lastname: García-Nieto
keywords: Acetazolamide; carbonic anhydrase inhibitor; craniometaphyseal dysplasia; osteochondrodysplasia; osteopetrosis; sclerosing bone dysplasia