title: Medium platelet volume as a noninvasive predictor of chronic total occlusion in non-infarct artery in patients with non-ST-segment elevation myocardial infarction and multivessel coronary artery disease.
abstract: BACKGROUND
  Chronic total occlusion (CTO) in a noninfarct-related artery (non-IRA) is an independent predictor of mortality in non-ST elevation myocardial infarction (NSTEMI). Mean platelet volume (MPV) is associated with cardiovascular events in NSTEMI. Little is known about the predictors of non-IRA-CTO in patients with NSTEMI. The purpose of this study was to evaluate the relationship between the presence of non-IRA-CTO with MPV level in patients with NSTEMI and multivessel coronary artery disease (MVCAD).
  
  
  METHODS
  Data of consecutive patients with NSTEMI and MVCAD treated in high-volume PCI center between 2006 and 2012 and included in the prospective registry were divided according to the presence of CTO and analyzed.
  
  
  RESULTS
  In the group of 685 patients fulfilling the inclusion criteria, 308 (45%) patients had CTO (CTO+), and in 377 (55%) patients CTO was not observed (CTO-). The MPV level on admission was significantly higher in the CTO+ group than in the CTO- group (P<0.0001). In the multivariate analysis of the entire study population, independent predictors of occurrence of CTO were medium platelet volume (MPV; per 1fL more; odds ratio [OR] 1.34; 95% confidence interval [CI] 1.15-1.57; P=0.0002) together with left ventricular ejection fraction and prior MI.
  
  
  CONCLUSIONS
  MPV at admission is independently associated with more frequent occurrence of non-IRA CTO in patients with NSTEMI and MVCAD.
authors.affiliation: 3rd Chair and Department of Cardiology, SMDZ in Zabrze, Medical University of Silesia, Katowice, Poland. Electronic address: mateusztajstra@wp.pl.
authors.forename: Mateusz
authors.initials: M
authors.lastname: Tajstra
authors.affiliation: 3rd Chair and Department of Cardiology, SMDZ in Zabrze, Medical University of Silesia, Katowice, Poland.
authors.forename: Michał
authors.initials: M
authors.lastname: Hawranek
authors.affiliation: 3rd Chair and Department of Cardiology, SMDZ in Zabrze, Medical University of Silesia, Katowice, Poland.
authors.forename: Piotr
authors.initials: P
authors.lastname: Desperak
authors.affiliation: 3rd Chair and Department of Cardiology, SMDZ in Zabrze, Medical University of Silesia, Katowice, Poland.
authors.forename: Aneta
authors.initials: A
authors.lastname: Ciślak
authors.affiliation: 3rd Chair and Department of Cardiology, SMDZ in Zabrze, Medical University of Silesia, Katowice, Poland.
authors.forename: Marek
authors.initials: M
authors.lastname: Gierlotka
authors.affiliation: 3rd Chair and Department of Cardiology, SMDZ in Zabrze, Medical University of Silesia, Katowice, Poland.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Lekston
authors.affiliation: 3rd Chair and Department of Cardiology, SMDZ in Zabrze, Medical University of Silesia, Katowice, Poland.
authors.forename: Lech
authors.initials: L
authors.lastname: Poloński
authors.affiliation: 3rd Chair and Department of Cardiology, SMDZ in Zabrze, Medical University of Silesia, Katowice, Poland.
authors.forename: Mariusz
authors.initials: M
authors.lastname: Gąsior
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001792:Blood Platelets; D002908:Chronic Disease; D017023:Coronary Angiography; D054059:Coronary Occlusion / Q000097:blood* / Q000175:diagnosis; D004562:Electrocardiography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D063847:Mean Platelet Volume; D008875:Middle Aged; D000072658:Non-ST Elevated Myocardial Infarction / Q000097:blood* / Q000175:diagnosis / Q000401:mortality; D011044:Poland / Q000453:epidemiology; D011237:Predictive Value of Tests; D012042:Registries; D012189:Retrospective Studies; D015996:Survival Rate / Q000639:trends; D013997:Time Factors
keywords: Chronic total occlusion; Mean platelet volume; Non-ST-segment elevation myocardial infarction; Percutaneous coronary intervention