title: Management of Post-Liver Transplant Recurrence of Hepatitis C.
abstract: Cirrhosis due to chronic hepatitis C (HCV) is the leading indication for liver transplantation in North America and Europe. HCV re-infection post-transplant is nearly universal and if left untreated negatively affects patient and graft survival. Until recently, treatment options for HCV were limited to interferon (IFN)-based therapies which had low sustained viral response (SVR) rates and were poorly tolerated in the post-transplant setting. In the last 3 years, the promise of the directly acting antivirals (DAAs) for the treatment of HCV has been fulfilled with high sustained viral response (SVR) rates and a low side effect profile demonstrated in both registration trials and real-world studies. This innovation has allowed post-liver transplant patients with HCV recurrence access to interferon-free therapies with extraordinary efficacy, safety, tolerability, and fewer drug-drug interactions.
authors.affiliation: Division of Gastroenterology and Hepatology, University of Washington, 1959 NE Pacific St., Seattle, WA, 98195-6424, USA.
authors.forename: Justin
authors.identifier: http://orcid.org/0000-0002-1074-7760
authors.initials: J
authors.lastname: Taylor
authors.affiliation: Division of Gastroenterology and Hepatology, University of Washington, 1959 NE Pacific St., Seattle, WA, 98195-6424, USA.
authors.forename: Paula
authors.initials: P
authors.lastname: Cox-North
authors.affiliation: Division of Gastroenterology and Hepatology, University of Washington, 1959 NE Pacific St., Seattle, WA, 98195-6424, USA. clandis@medicine.washington.edu.
authors.forename: Charles S
authors.initials: CS
authors.lastname: Landis
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use*; D019468:Disease Management; D004347:Drug Interactions; D016174:Hepacivirus / Q000187:drug effects*; D006526:Hepatitis C / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D007372:Interferons / Q000627:therapeutic use; D008103:Liver Cirrhosis / Q000209:etiology / Q000601:surgery; D016031:Liver Transplantation / Q000379:methods; D012008:Recurrence
chemical_list: D000998:Antiviral Agents; D007372:Interferons