title: New dinuclear ruthenium arene complexes containing thiosemicarbazone ligands: synthesis, structure and cytotoxic studies.
abstract: A series of mononuclear ruthenium arene complexes with thiosemicarbazone (TSC) ligands (A-type, 1-8) and their corresponding di-nuclear analogues (B-type, 9-16) were synthesized and characterized by NMR, elemental analysis and HR-ESI-mass spectrometry. The molecular structures of 1, 2, 6, 9-11 and 13-16 were determined using single-crystal X-ray diffraction analysis. The Gibbs free energy of the two examples of the two types of complexes (1 and 9) and the bonding order in their single-crystals were studied using density functional theory (DFT) calculations. The compounds were further evaluated for their in vitro antiproliferative activities against CNE-2 human nasopharyngeal carcinoma, KB human oral epithelial carcinoma, SGC-7901 human gastric carcinoma, HepG2 human liver carcinoma, HeLa human cervical carcinoma and HEK-293T noncancerous cell lines. Furthermore, the interactions between the compounds and DNA were studied by electrophoretic mobility spectrometry studies.
authors.affiliation: Key Laboratory of Environment Change and Resources Use in Beibu Gulf (Guangxi Teachers Education University), Ministry of Education, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Su
authors.affiliation: Key Laboratory of Environment Change and Resources Use in Beibu Gulf (Guangxi Teachers Education University), Ministry of Education, China.
authors.forename: Zhaofeng
authors.initials: Z
authors.lastname: Tang
authors.affiliation: College of Pharmacy, Guangxi University of Chinese Medicine, Nanning, China. lipearpear@163.com.
authors.forename: Peiyuan
authors.initials: P
authors.lastname: Li
authors.affiliation: Department of Chemistry, North Carolina State University, Raleigh, North Carolina 27695, USA.
authors.forename: Gufeng
authors.initials: G
authors.lastname: Wang
authors.affiliation: Key Laboratory of Environment Change and Resources Use in Beibu Gulf (Guangxi Teachers Education University), Ministry of Education, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Xiao
authors.affiliation: Key Laboratory of Environment Change and Resources Use in Beibu Gulf (Guangxi Teachers Education University), Ministry of Education, China.
authors.forename: Yuchun
authors.initials: Y
authors.lastname: Li
authors.affiliation: Key Laboratory of Environment Change and Resources Use in Beibu Gulf (Guangxi Teachers Education University), Ministry of Education, China.
authors.forename: Shan
authors.initials: S
authors.lastname: Huang
authors.affiliation: Key Laboratory of Environment Change and Resources Use in Beibu Gulf (Guangxi Teachers Education University), Ministry of Education, China.
authors.forename: Yunqiong
authors.initials: Y
authors.lastname: Gu
authors.affiliation: Department of Pharmacology, Guangxi Medicinal University, Nanning 530021, China.
authors.forename: Zefeng
authors.initials: Z
authors.lastname: Lai
authors.affiliation: Department of Chemistry, Hubei University, Wuhan 430062, China.
authors.forename: Yuexing
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D045744:Cell Line, Tumor; D056831:Coordination Complexes / Q000737:chemistry* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D006838:Hydrocarbons / Q000737:chemistry*; D008024:Ligands; D015394:Molecular Structure; D017975:Ruthenium Compounds / Q000737:chemistry*; D013882:Thiosemicarbazones / Q000737:chemistry*
chemical_list: D056831:Coordination Complexes; D006838:Hydrocarbons; D008024:Ligands; D017975:Ruthenium Compounds; D013882:Thiosemicarbazones