title: Different Effects of Myoinositol plus Folic Acid versus Combined Oral Treatment on Androgen Levels in PCOS Women.
abstract: Recently, myoinositol (myo-ins) and folic acid combination has gained an important role for treating Polycystic Ovary Syndrome (PCOS), in addition to combined oral contraceptives (COC). We aimed to examine myo-ins effects on anti-Mullerian hormone (AMH) levels and compare them with those ones obtained administering COC. In this prospective study, 137 PCOS patients, diagnosed according to Rotterdam criteria and admitted to the Reproductive Endocrinology and Infertility Outpatient Clinic at Dokuz Eylul University (Izmir, Turkey), were included. After randomization to COC (n= 60) and myo-ins (n= 77) arms, anthropometric measurements, blood pressure, Modified Ferriman Gallwey scores were calculated. Biochemical and hormonal analysis were performed, and LH/FSH and Apo B/A1 ratios were calculated. Data analysis was carried out in demographically and clinically matched 106 patients (COC = 54; myo-ins = 52). After 3-month treatment, increase in HDL and decreases in LH and LH/FSH ratio were statistically more significant only in COC group when compared with baseline (in both casesp> 0.05). In myo-ins group, fasting glucose, LDL, DHEAS, total cholesterol, and prolactin levels decreased significantly (for allp< 0.05). Progesterone and AMH levels, ovarian volume, ovarian antral follicle, and total antral follicle counts lessened significantly in both groups (for allp< 0.05). In PCOS treatment, MYO is observed more effective in reductions of total ovarian volume and AMH levels.
authors.affiliation: Aksehir State Hospital, Konya, Turkey.
authors.forename: Ali Cenk
authors.identifier: 0000-0002-6082-7101
authors.initials: AC
authors.lastname: Ozay
authors.affiliation: Aksehir State Hospital, Konya, Turkey.
authors.forename: Ozlen
authors.initials: O
authors.lastname: Emekci Ozay
authors.affiliation: Department of Obstetrics & Gynecology, Medical School, Dokuz Eylul University, Izmir, Turkey.
authors.forename: Recep Emre
authors.initials: RE
authors.lastname: Okyay
authors.affiliation: Department of Obstetrics & Gynecology, Medical School, Dokuz Eylul University, Izmir, Turkey.
authors.forename: Erkan
authors.initials: E
authors.lastname: Cagliyan
authors.affiliation: Department of Biochemistry, Medical School, Dokuz Eylul University, Izmir, Turkey.
authors.forename: Tuncay
authors.initials: T
authors.lastname: Kume
authors.affiliation: Department of Obstetrics & Gynecology, Medical School, Dokuz Eylul University, Izmir, Turkey.
authors.forename: Bulent
authors.initials: B
authors.lastname: Gulekli