title: Experimental, Theoretical and Biological Activity of a Triazonine- Derivative on Left Ventricular Pressure.
abstract: BACKGROUND
  There are data indicating that several azonine-derivatives may exert effects on some biological systems; however, there is very low information on the biological activity induced by these compounds on left ventricular pressure.
  
  
  OBJECTIVE
  The aim of this study was to synthesize and evaluate the biological activity of new triazoninederivative on left ventricular pressure.
  
  
  METHODS
  The first stage involved: 1) preparation of two azepine-benzamide derivatives (Z or E) by reaction of the nitrobenzoyl azide with adrenosterone; and 2) reaction of (Z)-azepine-benzamide derivative with ethylenediamine to form the triazonine derivative. The structure of compounds was confirmed by spectroscopy and spectrometry data. The second stage involved the biologic activity on left ventricular pressure was evaluated in a model of rat heart isolated. In addition, some physicochemical parameters were evaluated to characterize the possible molecules involved in its effect.
  
  
  RESULTS
  The results showed that only the triazonine increased left ventricular pressure via androgen receptor.
  
  
  CONCLUSIONS
  In conclusion, this phenomenon is conditioned by the functional groups involved in the chemical structure of triazonine derivative and their interaction with residues of amino acids involved on the androgen receptor surface.
authors.affiliation: Department of Pharmacochemistry, Faculty of Chemical Biological Sciences, University Autonomous of Campeche. Campeche, Mexico.
authors.forename: Lauro
authors.initials: L
authors.lastname: Figueroa-Valverde
authors.forename: Maria
authors.initials: M
authors.lastname: Lopez-Ramos
authors.forename: Marcela
authors.initials: M
authors.lastname: Rosas-Nexticapa
authors.forename: Socorro
authors.initials: S
authors.lastname: Herrera-Meza
authors.forename: Francisco
authors.initials: F
authors.lastname: Diaz-Cedillo
authors.forename: Elodia
authors.initials: E
authors.lastname: Garcia-Cervera
authors.forename: Eduardo
authors.initials: E
authors.lastname: Pool-Gomez
authors.forename: Tania
authors.initials: T
authors.lastname: Garcia-Camacho
authors.forename: Angel
authors.initials: A
authors.lastname: Aguilar-Villarino
mesh_terms: D000818:Animals; D001381:Azepines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001549:Benzamides / Q000138:chemical synthesis / Q000737:chemistry; D006576:Heterocyclic Compounds, 4 or More Rings / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D008297:Male; D062105:Molecular Docking Simulation; D017208:Rats, Wistar; D011944:Receptors, Androgen / Q000378:metabolism*; D016277:Ventricular Function, Left / Q000187:drug effects*; D017725:Ventricular Pressure / Q000187:drug effects*
chemical_list: D001381:Azepines; D001549:Benzamides; D006576:Heterocyclic Compounds, 4 or More Rings; D011944:Receptors, Androgen; C037689:benzamide
keywords: Adrenosterone; androgen receptor; benzamide; ethylenediamine; triazonine derivative; ventricular pressure