title: Exploring the activity of a polyazine bridged Ru(ii)-Pt(ii) supramolecule in F98 rat malignant glioma cells.
abstract: The mixed-metal supramolecular complex, [(Ph2phen)2Ru(dpp)PtCl2]2+, displays significant DNA modification, cell growth inhibition, and toxicity towards F98 malignant glioma cells following visible light irradiation. The design of this complex affords superior cellular uptake and antiproliferative activity compared to the classic chemotherapeutic agent, cisplatin.
authors.affiliation: Department of Chemistry, Virginia Tech., Blacksburg, Virginia 24061-0212, USA.
authors.forename: Jie
authors.initials: J
authors.lastname: Zhu
authors.affiliation: Department of Chemistry, Virginia Tech., Blacksburg, Virginia 24061-0212, USA.
authors.forename: José Á
authors.initials: JÁ
authors.lastname: Rodríguez-Corrales
authors.affiliation: School of Biomedical Engineering and Sciences, Virginia Tech., Blacksburg, Virginia 24061-0212, USA.
authors.forename: Reece
authors.initials: R
authors.lastname: Prussin
authors.affiliation: Department of Biological Systems Engineering, Virginia Tech., Blacksburg, Virginia 24061-0212, USA.
authors.forename: Zongmin
authors.initials: Z
authors.lastname: Zhao
authors.affiliation: School of Biomedical Engineering and Sciences, Virginia Tech., Blacksburg, Virginia 24061-0212, USA.
authors.forename: Anthony
authors.initials: A
authors.lastname: Dominijanni
authors.affiliation: Department of Chemistry, Virginia Tech., Blacksburg, Virginia 24061-0212, USA.
authors.forename: Samantha L
authors.initials: SL
authors.lastname: Hopkins
authors.affiliation: Department of Biological Sciences, Virginia Tech., Blacksburg, Virginia 24061-0406, USA. winkel@vt.edu.
authors.forename: Brenda S J
authors.identifier: 0000-0003-3481-024X
authors.initials: BS
authors.lastname: Winkel
authors.affiliation: School of Biomedical Engineering and Sciences, Virginia Tech., Blacksburg, Virginia 24061-0212, USA.
authors.forename: John L
authors.initials: JL
authors.lastname: Robertson
authors.forename: Karen J
authors.initials: KJ
authors.lastname: Brewer
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects / Q000528:radiation effects; D005910:Glioma / Q000473:pathology*; D008027:Light; D008958:Models, Molecular; D008968:Molecular Conformation; D009942:Organometallic Compounds / Q000737:chemistry* / Q000494:pharmacology*; D010984:Platinum / Q000737:chemistry*; D051381:Rats; D012428:Ruthenium / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D009942:Organometallic Compounds; D010984:Platinum; D012428:Ruthenium