title: Neurobehavioural evaluation of resveratrol in murine models of anxiety and schizophrenia.
abstract: Resveratrol, a caloric restriction mimetic, is a naturally occurring polyphenolic compound with antioxidant and anti-inflammatory properties. Oxidative stress has been implicated in the etiology of a number of neuropsychiatric disorders including generalized anxiety and schizophrenia. This study investigated the anxiolytic and antipsychotic potentials of resveratrol in murine models of anxiety and schizophrenia. Mice were pretreated with resveratrol (200 and 400 mg/kg) in 1% carboxymethyl cellulose for 14 days and subjected to behavioural tests on the 15th day. Anxiolytic activity of resveratrol was determined using the hole board and staircase tests while its anti-psychotic property was evaluated via apormorphine induced stereotypy and swim-induced grooming tests. Although resveratrol did not significantly reduce the mean number of head dips at doses used in the hole board test, it significantly (p < 0.01) decreased the mean episodes of rearing without significantly altering the total number of upward steps climbed in the staircase test. Resveratrol significantly (p < 0.05) reduced the mean climbing scores in the first ten minutes of the apormorphine induced stereotypic climbing and significantly decreased (p < 0.01) episodes and total duration of swim induced grooming in mice. Administration of resveratrol at doses used in this study produced anxiolysis and anti-psychotic effects in mice.
authors.affiliation: Department of Pharmacology and Therapeutics, Ahmadu Bello University, Zaria, Nigeria.
authors.forename: Mohammed Garba
authors.initials: MG
authors.lastname: Magaji
authors.affiliation: Department of Pharmacology and Toxicology, University of Benin, Benin, Nigeria. lo.iniaghe@uniben.edu.
authors.forename: Loretta Oghenekome
authors.initials: LO
authors.lastname: Iniaghe
authors.affiliation: Faculty of Pharmaceutical Sciences, Ahmadu Bello University, Zaria, Nigeria.
authors.forename: Mutiat
authors.initials: M
authors.lastname: Abolarin
authors.affiliation: Faculty of Pharmaceutical Sciences, Ahmadu Bello University, Zaria, Nigeria.
authors.forename: Opeyemi Isa
authors.initials: OI
authors.lastname: Abdullahi
authors.affiliation: Department of Human Physiology, Faculty of Medicine, Ahmadu Bello University, Zaria, Nigeria.
authors.forename: Rabiu Abdusalam
authors.initials: RA
authors.lastname: Magaji
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001007:Anxiety / Q000139:chemically induced / Q000188:drug therapy* / Q000523:psychology*; D001058:Apomorphine; D001522:Behavior, Animal / Q000187:drug effects; D031204:Caloric Restriction; D005106:Exploratory Behavior / Q000187:drug effects; D005260:Female; D006120:Grooming / Q000187:drug effects; D008297:Male; D051379:Mice; D000077185:Resveratrol; D012559:Schizophrenia / Q000139:chemically induced / Q000188:drug therapy*; D012565:Schizophrenic Psychology; D013239:Stereotyped Behavior / Q000187:drug effects; D013267:Stilbenes / Q000627:therapeutic use*; D013550:Swimming
chemical_list: D000975:Antioxidants; D014150:Antipsychotic Agents; D013267:Stilbenes; D001058:Apomorphine; D000077185:Resveratrol
keywords: Anxiety; Apormorphine; Caloric restriction; Oxidative stress; Psychosis; Resveratrol