title: Establishing Tolerance to Commensal Skin Bacteria: Timing Is Everything.
abstract: Commensal bacteria live intimately and in constant dialogue with skin immune cells. Regulating our immune response to these bacteria is critical for skin homeostasis. Using a new murine model to track Staphylococcus epidermidis-specific T cells, we found that colonization during neonatal but not adult life led to S.epidermidis-specific immune tolerance. This tolerance protected against skin inflammation and was mediated by a wave of regulatory T cells entering neonatal skin. These findings provide new insight into how we establish a healthy symbiosis with commensal microbes and highlight avenues for future research to identify novel therapies for inflammatory skin disease.
authors.affiliation: Department of Dermatology, University of California, San Francisco, 1701 Divisadero Street, 3rd Floor, San Francisco, CA 94115, USA. Electronic address: tiffany.scharschmidt@ucsf.edu.
authors.forename: Tiffany C
authors.initials: TC
authors.lastname: Scharschmidt
mesh_terms: D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology*; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology*; D007113:Immunity, Innate / Q000276:immunology; D051379:Mice; D064307:Microbiota / Q000276:immunology; D011425:Propionibacterium acnes / Q000276:immunology; D012867:Skin / Q000276:immunology* / Q000382:microbiology; D013212:Staphylococcus epidermidis / Q000276:immunology; D013559:Symbiosis / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D013997:Time Factors
chemical_list: D000942:Antigens, Bacterial
keywords: Commensals; Microbiome; Neonatal; Skin; Tolerance; Tregs