title: Identification of bile survivin and carbohydrate antigen 199 in distinguishing cholangiocarcinoma from benign obstructive jaundice.
abstract: OBJECTIVE
  To investigate whether bile survivin and carbohydrate antigen 199 (CA199) can be helpful in distinguishing cholangiocarcinoma (malignant obstructive jaundice) from benign obstructive jaundice.
  
  
  METHODS
  Receiver operating characteristic curve was used to evaluate the feasibility of bile survivin and CA199 in differentiating cholangiocarcinoma from benign obstructive jaundice.
  
  
  RESULTS
  The area under the curve for survivin and CA199 in bile and serum were 0.780 (p < 0.001), 0.6 (p = 0.084), 0.746 (p < 0.001) and 0.542 (p = 0.464), respectively. Combination of bile survivin and CA199 could improve the diagnostic capability.
  
  
  CONCLUSIONS
  Bile survivin and CA199 are significantly increased in patients with cholangiocarcinoma and may be useful biomarkers in differentiating distinguishing cholangiocarcinoma from benign obstructive jaundice.
authors.affiliation: Department of Hepatobiliary Surgery, Qilu Hospital of Shandong University, Jinan 250012, China.
authors.forename: Yanfeng
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Surgery, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250011, China.
authors.forename: Jingxian
authors.initials: J
authors.lastname: Sun
authors.affiliation: Department of Hepatobiliary Surgery, Qilu Hospital of Shandong University, Jinan 250012, China.
authors.forename: Qiangbo
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Department of Hepatobiliary Surgery, Qilu Hospital of Shandong University, Jinan 250012, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Jin
authors.affiliation: Department of Hepatobiliary Surgery, Qilu Hospital of Shandong University, Jinan 250012, China.
authors.forename: Min
authors.initials: M
authors.lastname: Zhu
authors.affiliation: Department of Hepatobiliary Surgery, Qilu Hospital of Shandong University, Jinan 250012, China.
authors.forename: Zongli
authors.initials: Z
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000097:blood*; D019540:Area Under Curve; D001646:Bile / Q000378:metabolism*; D001650:Bile Duct Neoplasms / Q000175:diagnosis*; D014408:Biomarkers, Tumor / Q000032:analysis / Q000097:blood; D018281:Cholangiocarcinoma / Q000175:diagnosis*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins / Q000032:analysis* / Q000097:blood; D041781:Jaundice, Obstructive / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D012372:ROC Curve; D000077022:Survivin
chemical_list: D015295:Antigens, Tumor-Associated, Carbohydrate; C107489:BIRC5 protein, human; D014408:Biomarkers, Tumor; D051034:Inhibitor of Apoptosis Proteins; D000077022:Survivin; C578959:carbohydrate antigen 199, human
keywords: bile CA199; bile survivin; cholangiocarcinoma; diagnosis; obstructive jaundice