title: Curcumin and Boswellia serrata Modulate the Glyco-Oxidative Status and Lipo-Oxidation in Master Athletes.
abstract: BACKGROUND
  Chronic intensive exercise is associated with a greater induction of oxidative stress and with an excess of endogenous advanced glycation end-products (AGEs). Curcumin can reduce the accumulation of AGEs in vitro and in animal models. We examined whether supplementation with curcumin andBoswellia serrata(BSE) gum resin for 3 months could affect plasma levels of markers of oxidative stress, inflammation, and glycation in healthy master cyclists.
  
  
  METHODS
  Forty-seven healthy male athletes were randomly assigned to Group 1, consisting of 22 subjects given a Mediterranean diet (MD) alone (MD group), and Group 2 consisted of 25 subjects given a MD plus curcumin and BSE (curcumin/BSE group). Interleukin-6 (IL-6), tumor necrosis factor-α (TNFα), high-sensitivity c-reactive protein (hs-CRP), total AGE, soluble receptor for AGE (sRAGE), malondialdehyde (MDA), plasma phospholipid fatty acid (PPFA) composition, and non-esterified fatty acids (NEFA) were tested at baseline and after 12 weeks.
  
  
  RESULTS
  sRAGE, NEFA, and MDA decreased significantly in both groups, while only the curcumin/BSE group showed a significant decline in total AGE. Only the changes in total AGE and MDA differed significantly between the curcumin/BSE and MD groups.
  
  
  CONCLUSIONS
  Our data suggest a positive effect of supplementation with curcumin and BSE on glycoxidation and lipid peroxidation in chronically exercising master athletes.
authors.affiliation: Department of Medicine-DIMED, University of Padova, Diabetology and Dietetics, ULSS 16, via dei Colli, 4, 35100 Padova, Italy. ninocristiano.chilelli@phd.unipd.it.
authors.forename: Nino Cristiano
authors.initials: NC
authors.lastname: Chilelli
authors.affiliation: Department of Pharmaceutical and Pharmacological Sciences, University of Padova, 35100 Padova, Italy. eugenio.ragazzi@unipd.it.
authors.forename: Eugenio
authors.initials: E
authors.lastname: Ragazzi
authors.affiliation: Department of Medicine-DIMED, University of Padova, Diabetology and Dietetics, ULSS 16, via dei Colli, 4, 35100 Padova, Italy. romina.valentini@unipd.it.
authors.forename: Romina
authors.initials: R
authors.lastname: Valentini
authors.affiliation: Department of Laboratory Medicine, University of Padova, 35100 Padova, Italy. chiara.cosma@sanita.padova.it.
authors.forename: Chiara
authors.initials: C
authors.lastname: Cosma
authors.affiliation: Department of Medicine-DIMED, University of Padova, Diabetology and Dietetics, ULSS 16, via dei Colli, 4, 35100 Padova, Italy. stefania.ferraresso@alice.it.
authors.forename: Stefania
authors.initials: S
authors.lastname: Ferraresso
authors.affiliation: Department of Medicine-DIMED, University of Padova, Diabetology and Dietetics, ULSS 16, via dei Colli, 4, 35100 Padova, Italy. annunziata.lapolla@unipd.it.
authors.forename: Annunziata
authors.initials: A
authors.lastname: Lapolla
authors.affiliation: Department of Medicine-DIMED, University of Padova, Diabetology and Dietetics, ULSS 16, via dei Colli, 4, 35100 Padova, Italy. g.sartore@unipd.it.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Sartore
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000975:Antioxidants / Q000008:administration & dosage*; D056352:Athletes; D001642:Bicycling; D029743:Boswellia / Q000737:chemistry*; D003474:Curcumin / Q000008:administration & dosage*; D038441:Diet, Mediterranean; D019587:Dietary Supplements; D017127:Glycation End Products, Advanced / Q000378:metabolism*; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood; D007558:Italy; D015227:Lipid Peroxidation / Q000187:drug effects*; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000187:drug effects*; D010807:Physical Endurance; D008517:Phytotherapy; D010865:Pilot Projects; D010936:Plant Extracts / Q000008:administration & dosage* / Q000302:isolation & purification; D010946:Plants, Medicinal; D013997:Time Factors
chemical_list: D000975:Antioxidants; D017127:Glycation End Products, Advanced; D018836:Inflammation Mediators; D008055:Lipids; D010936:Plant Extracts; D003474:Curcumin
keywords: advanced glycation end-products; curcumin; exercise; inflammation; oxidative stress