title: Neonatal Diabetes: A Case Series.
abstract: BACKGROUND
  Neonatal diabetes mellitusis a rare disorder with an incidence of 1 in 2,60,000 live births.
  
  
  METHODS
  Retrospective analysis of clinical and genetic profile of children admitted with neonatal diabetes mellitus in a tertiary-care hospital in Chennai, India over 11 years.
  
  
  RESULTS
  Ten children were diagnosed with neonatal diabetes of whom 9 had permanent neonatal diabetes mellitus. The age range at onset was from 3 days- 5 months. Of the 9 children, KCNJ11 gene mutation was positive in one, and ABCC 8 and INS gene mutation in two children each. Children with KCNJ11 and ABCC 8 gene mutations were switched over to oral sulfonyl urea therapy.
  
  
  CONCLUSIONS
  Few genotypes causing NDM can be managed effectively with oral sulfonyl ureas.
authors.affiliation: Departments of Pediatrics and *Endocrinology, Kanchi Kamakoti CHILDS Trust Hospital and The CHILDS Trust Medical Research Foundation, Chennai, Tamil Nadu, India. Correspondence to: Dr Ramaswamy Ganesh, Consultant Pediatrician, Kanchi Kamakoti CHILDS Trust Hospital, Chennai 600 034, India. ganeped79@rediffmail.com.
authors.forename: Ramaswamy
authors.initials: R
authors.lastname: Ganesh
authors.forename: Natarajan
authors.initials: N
authors.lastname: Suresh
authors.forename: Thiruvengadam
authors.initials: T
authors.lastname: Vasanthi
authors.forename: K G
authors.initials: KG
authors.lastname: Ravikumar
mesh_terms: D003920:Diabetes Mellitus / Q000175:diagnosis* / Q000235:genetics*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D024661:Potassium Channels, Inwardly Rectifying / Q000235:genetics; D064233:Sulfonylurea Receptors / Q000235:genetics; D000099161:Kcnj11 Channel
chemical_list: D024661:Potassium Channels, Inwardly Rectifying; D064233:Sulfonylurea Receptors; D000099161:Kcnj11 Channel; C577507:ABCC8 protein, human