title: Fatal Hemorrhagic Gastrointestinal Angioectasia after Bone Marrow Transplantation for Dyskeratosis Congenita.
abstract: Dyskeratosis congenita (DC) is a rare inherited disease in which the telomere complex cannot be maintained. Shortened telomeres can cause a number of clinical conditions. We herein report a case of unrelated bone marrow transplantation due to aplastic anemia associated with DC. The patient died of uncontrollable refractory intestinal bleeding. Three cases of DC with life-threatening hemorrhaging after transplantation have been reported; however, the bleeding origin could not be determined. Our case is the only patient in which a gastrointestinal bleeding point, jejunal multiple angioectasia, was determined.
authors.affiliation: Department of Gastroenterology, Tokai University School of Medicine, Japan.
authors.forename: Jin
authors.initials: J
authors.lastname: Imai
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Suzuki
authors.forename: Marie
authors.initials: M
authors.lastname: Yoshikawa
authors.forename: Makiko
authors.initials: M
authors.lastname: Dekiden
authors.forename: Hirohiko
authors.initials: H
authors.lastname: Nakae
authors.forename: Fumio
authors.initials: F
authors.lastname: Nakahara
authors.forename: Shingo
authors.initials: S
authors.lastname: Tsuda
authors.forename: Hajime
authors.initials: H
authors.lastname: Mizukami
authors.forename: Jun
authors.initials: J
authors.lastname: Koike
authors.forename: Muneki
authors.initials: M
authors.lastname: Igarashi
authors.forename: Hiromasa
authors.initials: H
authors.lastname: Yabe
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Mine
mesh_terms: D000741:Anemia, Aplastic / Q000209:etiology / Q000628:therapy*; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D004108:Dilatation, Pathologic / Q000209:etiology*; D019871:Dyskeratosis Congenita / Q000150:complications; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000209:etiology*; D006801:Humans; D055815:Young Adult