title: Use of fibrin glue as a sealant at the anastomotic line in laparoscopic pyeloplasty: A randomised controlled trial.
abstract: OBJECTIVE
  To assess the effectiveness of fibrin glue as a sealant at the anastomotic line of a stentless laparoscopic pyeloplasty (LPP) repair instead of JJ stent insertion.
  
  
  METHODS
  In all, 46 patients with pelvi-ureteric junction obstruction scheduled for LPP were randomised into two groups each containing 23 patients. Group A underwent stented repair, while group B had a stentless repair together with sealing of the anastomotic line with fibrin glue.
  
  
  RESULTS
  There was no statistically significant difference between the groups for the postoperative improvement in the renal scan and intravenous urography. However, there was a statistically significant decrease in early postoperative adverse events in group B. In group A, all the patients had irritative lower urinary tract symptoms (LUTS) and 16 (72.7%) had postoperative urinary tract infections (UTIs). In group B, no patient had a UTI or irritative LUTS. In all, 21 patients (95.4%) in group A had minimal terminal painful haematuria; while in group B, only one patient (4.3%) had minimal total painless haematuria. Also, patients in group B were spared the need for a second anaesthesia exposure for stent removal.
  
  
  CONCLUSIONS
  The use of fibrin glue is a valid alternative to stenting in LPP with the same excellent outcome but with markedly lower short-term postoperative adverse events.
authors.affiliation: Department of Urology, Ain Shams University Hospital, Cairo, Egypt.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Farouk
authors.affiliation: Department of Urology, Ain Shams University Hospital, Cairo, Egypt.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Tawfick
authors.affiliation: Department of Urology, Ain Shams University Hospital, Cairo, Egypt.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Kotb
authors.affiliation: Department of Urology, Ain Shams University Hospital, Cairo, Egypt.
authors.forename: Alaa
authors.initials: A
authors.lastname: Abdellmaksoud
authors.affiliation: Department of Urology, Ain Shams University Hospital, Cairo, Egypt.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Safaan
authors.affiliation: Department of Urology, Ain Shams University Hospital, Cairo, Egypt.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Yassin
authors.affiliation: Department of Urology, Ain Shams University Hospital, Cairo, Egypt.
authors.forename: Hassan
authors.initials: H
authors.lastname: Shaker
keywords: CONSORT, Consolidated Standards of Reporting Trials; DTPA, diethylene-triamine-penta-acetic acid; Fibrin glue; LPP, laparoscopic pyeloplasty; Laparoscopic pyeloplasty; PUJ obstruction; PUJO, PUJ obstruction; Stentless pyeloplasty; T½, clearance half-time (renogram)