title: Increased serum concentrations of asymmetric dimethylarginine (ADMA) in patients with early-onset coronary artery disease.
abstract: BACKGROUND
  Asymmetric dimethylarginine (ADMA) has been associated with an increased risk of cardiovascular disease. We investigated the role of serum ADMA concentrations in early-onset coronary artery disease (EOCAD).
  
  
  METHODS
  Candidates for coronary artery angiography (age<50y for men and <55y for women) who met the inclusion criteria were enrolled in this study. Serum concentrations of ADMA were determined using ELISA. Severity of coronary atherosclerosis was estimated by number of diseased vessels.
  
  
  RESULTS
  A total of 601 subjects (286 with EOCAD patients and 315 controls) were included in the study. ADMA concentrations were found to be significantly higher in the EOCAD group (0.480±0.110μmol/l) than in the control group (0.457±0.091, P=0.007). ADMA concentrations significantly increased with the number of diseased vessels (P<0.001). In addition, serum ADMA concentrations were affected by diabetes mellitus and smoking status, and were positively correlated with serum creatinine and body mass index (BMI).
  
  
  CONCLUSIONS
  Our results show that serum ADMA concentrations were associated with the presence and severity of EOCAD, suggesting that ADMA may be involved in the progression of EOCAD.
authors.affiliation: Department of Clinical Laboratory, The Affiliated Hospital of Qingdao University, Qingdao, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Xuan
authors.affiliation: Department of Emergency Medicine, The Affiliated Hospital of Qingdao University, Qingdao, China.
authors.forename: Zhen-Fang
authors.initials: ZF
authors.lastname: Liu
authors.affiliation: Department of Clinical Laboratory, The Affiliated Hospital of Qingdao University, Qingdao, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Department of Clinical Laboratory, Qingdao Women and Children's Hospital, Qingdao, China.
authors.forename: Fen-Fen
authors.initials: FF
authors.lastname: Guo
authors.affiliation: Department of Anesthesiology, The Affiliated Hospital of Qingdao University, Qingdao, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Surgery, TEDA International Cardiovascular Hospital, Tianjin, China; Department of Cardiovascular Surgery, The Affiliated Hospital of Hangzhou Normal University and Zhejiang University, Hangzhou, China; Department of Surgery, Oregon Health and Science University, Portland, OR, United States.
authors.forename: Guo-Wei
authors.initials: GW
authors.lastname: He
authors.affiliation: Department of Clinical Laboratory, The Affiliated Hospital of Qingdao University, Qingdao, China. Electronic address: lunlmqd@163.com.
authors.forename: Li-Min
authors.initials: LM
authors.lastname: Lun
mesh_terms: D017668:Age of Onset; D001120:Arginine / Q000031:analogs & derivatives* / Q000097:blood; D003324:Coronary Artery Disease / Q000097:blood* / Q000453:epidemiology; D003331:Coronary Vessels / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012306:Risk
chemical_list: C018524:N,N-dimethylarginine; D001120:Arginine
keywords: Asymmetric dimethylarginine; Disease severity; Early-onset coronary artery disease; Risk factor