title: Incidence and survival outcomes of chronic myelomonocytic leukemia in the United States.
abstract: Chronic myelomonocytic leukemia (CMML) is an aggressive neoplasm with sparse data on outcomes at a population level. Using Surveillance Epidemiology and End Results (SEER) database, we identified 2238 patients with CMML diagnosed in the period 2003-2013. We found that the disease incidence was significantly higher with advancing age and lower in females, Blacks, and Asian/pacific islanders. Median OS declined significantly with increasing age (age 20-39 - 25 months, age 40-59 - 20 months, age 60-79 - 18 months, and age ≥80 - 11 months, p < .01), but did not vary by gender or race. Median OS has improved in the period 2007-2013 as compared with 2003-2006 (17 months vs. 14 months, p < .01). In spite of advances in CMML biology and therapeutics, in general, the survival of CMML patients remains dismal. More effective therapies are needed to improve the outcomes of CMML.
authors.affiliation: a Division of Medicine , University of Arkansas for Medical Sciences , Little Rock , AR , USA.
authors.forename: Guru Subramanian
authors.initials: GS
authors.lastname: Guru Murthy
authors.affiliation: b Division of Biostatistics , University of Arkansas for Medical Sciences , Little Rock , AR , USA.
authors.forename: Ishwori
authors.initials: I
authors.lastname: Dhakal
authors.affiliation: c Division of Hematology/Oncology , University of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System , Little Rock , AR , USA.
authors.forename: Paulette
authors.initials: P
authors.lastname: Mehta
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D015994:Incidence; D015477:Leukemia, Myelomonocytic, Chronic / Q000453:epidemiology* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D063868:Patient Outcome Assessment; D011159:Population Surveillance; D011379:Prognosis; D018426:SEER Program; D016019:Survival Analysis; D014481:United States / Q000453:epidemiology; D055815:Young Adult
keywords: Leukemia; SEER; chronic; incidence; myelomonocytic; survival