title: LINC00978 predicts poor prognosis in breast cancer patients.
abstract: Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death among women worldwide. Long non-coding RNAs (lncRNAs) are a class of non-coding RNAs in the human genome that involves in breast cancer development and progression. Here, we identify a lncRNA, LINC00978, which is upregulated in breast cancer cell lines and tissues compared with corresponding controls. Furthermore, LINC00978 expression is negatively associated with hormone receptor (HR) status in 195 breast cancer patients studied (p = 0.033). Kaplan-Meier survival analysis shows that patients with high LINC00978 expression have poorer disease-free survival (DFS) than those with low LINC00978 expression (p = 0.012), and multivariate analysis identifies LINC00978 as an independent prognostic factor in breast cancer (p = 0.008, hazard ratio [HR] = 2.270, 95% confidence interval [CI] 1.237-4.165). Our study indicates that LINC00978 may be an oncogene in breast cancer, and can serve as a potential biomarker to predict prognosis in breast cancer patients.
authors.affiliation: Department of Breast Surgery, Fudan University Shanghai Cancer Center, 200032, China.|Department of General Surgery, the Second Affiliated Hospital of Nanchang University, Nanchang, 330006, China.
authors.forename: Lin-Lin
authors.initials: LL
authors.lastname: Deng
authors.affiliation: Department of Breast Surgery, Fudan University Shanghai Cancer Center, 200032, China.|Department of Oncology, Fudan University, Shanghai Medical College, Shanghai, 200032, China.
authors.forename: Ya-Yun
authors.initials: YY
authors.lastname: Chi
authors.affiliation: Department of Breast Surgery, Fudan University Shanghai Cancer Center, 200032, China.|Department of General Surgery, the Second Affiliated Hospital of Nanchang University, Nanchang, 330006, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Liu
authors.affiliation: Department of Breast Surgery, Fudan University Shanghai Cancer Center, 200032, China.|Department of Oncology, Fudan University, Shanghai Medical College, Shanghai, 200032, China.
authors.forename: Nai-Si
authors.initials: NS
authors.lastname: Huang
authors.affiliation: Department of General Surgery, the Second Affiliated Hospital of Nanchang University, Nanchang, 330006, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Breast Surgery, Fudan University Shanghai Cancer Center, 200032, China.|Department of Oncology, Fudan University, Shanghai Medical College, Shanghai, 200032, China.|Collaborative Innovation Center for Cancer Medicine, China.
authors.forename: Jiong
authors.initials: J
authors.lastname: Wu
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics*; D001943:Breast Neoplasms / Q000235:genetics / Q000473:pathology*; D015331:Cohort Studies; D018450:Disease Progression; D005260:Female; D006801:Humans; D008875:Middle Aged; D011379:Prognosis; D062085:RNA, Long Noncoding / Q000235:genetics*; D015996:Survival Rate
chemical_list: D014408:Biomarkers, Tumor; D062085:RNA, Long Noncoding; C000632564:MIR4435-2HG long non-coding RNA, human