title: Local Administration of Tranexamic Acid During Prostatectomy Surgery: Effects on Reducing the Amount of Bleeding.
abstract: BACKGROUND
  One of the issues in prostatectomy surgery is bleeding. Although tranexamic acid (TRA) is an antifibrinolytic agent for reducing bleeding, controversies surround its use.
  
  
  OBJECTIVE
  In this study, the effect of local administration of TRA on reducing bleeding during prostatectomy surgery was evaluated.
  
  
  METHODS
  A total of 186 patients who underwent prostatectomy surgery were assessed in this clinical trial study. Patients were divided randomly into two groups. After prostate removal, TRA (500 mg TRA with 5 mL total volume) to the intervention group and normal saline to the control group were sprayed with the same volume. At the end of surgery, the prescribed blood bags were measured and recorded. Hemoglobin and platelet levels were recorded 6 hours after the test. Moreover, the amounts of blood inside the blood bags in the first 24 hours, the second 24 hours, and the total length of hospital stay were recorded and compared in each group.
  
  
  RESULTS
  By comparing the measured values before and after surgery, we found that the amounts of hemoglobin, hematocrit, and platelet decreased. The mean blood loss in the intervention group was recorded at 340 mL and that in the control group was 515 mL. The maximum bleeding in the control group was almost twice as much as that in the intervention group. Blood loss in the intervention group with the administration of TRA was significantly lesser than that in the control group (P = 0.01). The decrease in platelet level in the intervention group was significantly lower than that in the control group (P = 0.03).
  
  
  CONCLUSIONS
  The present study showed that local administration of TRA significantly reduces bleeding after prostatectomy surgery and is effective in preventing postoperative hemoglobin decrease.
authors.affiliation: Department of Anesthesiology, Tehran University of Medical Sciences, Tehran, IR Iran.
authors.forename: Pejman
authors.initials: P
authors.lastname: Pourfakhr
authors.affiliation: Department of Anesthesiology, Tehran University of Medical Sciences, Tehran, IR Iran.
authors.forename: Elham
authors.initials: E
authors.lastname: Gatavi
authors.affiliation: Department of Urology, Tehran University of Medical Sciences, Tehran, IR Iran.
authors.forename: Shahram
authors.initials: S
authors.lastname: Gooran
authors.affiliation: Department of Anesthesiology, Tehran University of Medical Sciences, Tehran, IR Iran.
authors.forename: Farhad
authors.initials: F
authors.lastname: Etezadi
authors.affiliation: Department of Anesthesiology, Tehran University of Medical Sciences, Tehran, IR Iran.
authors.forename: Mohamad Reza
authors.initials: MR
authors.lastname: Khajavi
authors.affiliation: Department of Anesthesiology, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran.
authors.forename: Reza
authors.initials: R
authors.lastname: Pourroustaei
authors.affiliation: Department of Anesthesiology, Tehran University of Medical Sciences, Tehran, IR Iran.
authors.forename: Reza
authors.initials: R
authors.lastname: Shariat Moharari
authors.affiliation: Department of Anesthesiology, Tehran University of Medical Sciences, Tehran, IR Iran.
authors.forename: Atabak
authors.initials: A
authors.lastname: Najafi
keywords: Bleeding; Prostatectomy; Tranexamic Acid