title: Parvalbumin- and vasoactive intestinal polypeptide-expressing neocortical interneurons impose differential inhibition on Martinotti cells.
abstract: Disinhibition of cortical excitatory cell gate information flow through and between cortical columns. The major contribution of Martinotti cells (MC) is providing dendritic inhibition to excitatory neurons and therefore they are a main component of disinhibitory connections. Here we show by means of optogenetics that MC in layers II/III of the mouse primary somatosensory cortex are inhibited by both parvalbumin (PV)- and vasoactive intestinal polypeptide (VIP)-expressing cells. Paired recordings revealed stronger synaptic input onto MC from PV cells than from VIP cells. Moreover, PV cell input showed frequency-independent depression, whereas VIP cell input facilitated at high frequencies. These differences in the properties of the two unitary connections enable disinhibition with distinct temporal features.
authors.affiliation: University Medical Center Göttingen, Institute for Neuroanatomy, Göttingen 37075, Germany.
authors.forename: F
authors.initials: F
authors.lastname: Walker
authors.affiliation: University Medical Center Göttingen, Institute for Neuroanatomy, Göttingen 37075, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Möck
authors.affiliation: University Medical Center Göttingen, Institute for Neuroanatomy, Göttingen 37075, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Feyerabend
authors.affiliation: University Medical Center Göttingen, Institute for Neuroanatomy, Göttingen 37075, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Guy
authors.affiliation: University Medical Center Göttingen, Institute for Neuroanatomy, Göttingen 37075, Germany.
authors.forename: R J
authors.initials: RJ
authors.lastname: Wagener
authors.affiliation: Radboud University Medical Centre Nijmegen, Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, 6525 EN Nijmegen, Netherlands.
authors.forename: D
authors.identifier: 0000-0002-1202-4363
authors.initials: D
authors.lastname: Schubert
authors.affiliation: University Medical Center Göttingen, Institute for Neuroanatomy, Göttingen 37075, Germany.
authors.forename: J F
authors.initials: JF
authors.lastname: Staiger
authors.affiliation: University Medical Center Göttingen, Institute for Neuroanatomy, Göttingen 37075, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Witte
mesh_terms: D000818:Animals; D007395:Interneurons / Q000378:metabolism*; D051379:Mice; D019579:Neocortex / Q000378:metabolism*; D009433:Neural Inhibition; D009473:Neuronal Plasticity; D010320:Parvalbumins / Q000378:metabolism*; D013003:Somatosensory Cortex / Q000166:cytology*; D013569:Synapses / Q000378:metabolism; D014660:Vasoactive Intestinal Peptide / Q000378:metabolism*; D014793:Visual Cortex / Q000378:metabolism
chemical_list: D010320:Parvalbumins; D014660:Vasoactive Intestinal Peptide