title: Selective Tsuji-Trost type C-allylation of hydrazones: a straightforward entry into 4,5-dihydropyrazoles.
abstract: The 4,5-dihydropyrazole motif has drawn considerable attention over the years as it was shown to exhibit a plethora of biological and pharmacological properties, including anticancer, antibacterial, antifungal, antiviral, and anti-inflammatory properties. As such, it has been the target of a number of methods and drug discovery programs. We report here a straightforward and highly selective approach featuring a key palladium-catalysed Tsuji-Trost type C-allylation and subsequent intramolecular 1,4-addition of hydrazones.
authors.affiliation: Laboratoire de Synthèse Organique, CNRS, Ecole Polytechnique, ENSTA ParisTech-UMR 7652, Université Paris-Saclay, 828 Bd des Maréchaux, 91128, Palaiseau, France. laurent.elkaim@ensta-paristech.fr and Laboratoire de Chimie Organique, Institute of Chemistry, Biology and Innovation (CBI)-ESPCI Paris/CNRS (UMR8231)/PSL Research University, 10 rue Vauquelin, 75231 Paris Cedex 05, France.
authors.forename: El Hachemia
authors.initials: EH
authors.lastname: El Mamouni
authors.affiliation: Queen Mary University of London, School of Biological and Chemical Sciences, Mile End Road, London, E1 4NS, UK.
authors.forename: Martin
authors.identifier: http://orcid.org/0000-0002-9343-5948
authors.initials: M
authors.lastname: Cattoen
authors.affiliation: Laboratoire de Chimie Moléculaire, UMR 9168, Department of Chemistry, Ecole Polytechnique, CNRS, 91128, Palaiseau Cedex, France.
authors.forename: Marie
authors.initials: M
authors.lastname: Cordier
authors.affiliation: Laboratoire de Chimie Organique, Institute of Chemistry, Biology and Innovation (CBI)-ESPCI Paris/CNRS (UMR8231)/PSL Research University, 10 rue Vauquelin, 75231 Paris Cedex 05, France.
authors.forename: Janine
authors.initials: J
authors.lastname: Cossy
authors.affiliation: Laboratoire de Chimie Organique, Institute of Chemistry, Biology and Innovation (CBI)-ESPCI Paris/CNRS (UMR8231)/PSL Research University, 10 rue Vauquelin, 75231 Paris Cedex 05, France and Queen Mary University of London, School of Biological and Chemical Sciences, Mile End Road, London, E1 4NS, UK.
authors.forename: Stellios
authors.initials: S
authors.lastname: Arseniyadis
authors.affiliation: Laboratory of the Chemistry and Electrochemistry of the Metallic Complexes, Department of Chemistry, Faculty of Sciences, University of Sciences and Technology of Oran Mohamed Boudiaf (U.S.T.O.M.B.), Algeria.
authors.forename: Hocine
authors.initials: H
authors.lastname: Ilitki
authors.affiliation: Laboratoire de Synthèse Organique, CNRS, Ecole Polytechnique, ENSTA ParisTech-UMR 7652, Université Paris-Saclay, 828 Bd des Maréchaux, 91128, Palaiseau, France. laurent.elkaim@ensta-paristech.fr.
authors.forename: Laurent
authors.initials: L
authors.lastname: El Kaïm