title: Facile one-pot synthesis of Fe3O4@chitosan nanospheres for MRI and fluorescence imaging guided chemo-photothermal combinational cancer therapy.
abstract: Multifunctional nanoplatforms that integrate imaging and chemo-photothermal therapy for highly efficient cancer diagnostics and therapeutics have gained great interest in recent years. Herein, we designed and synthesized biodegradable and biocompatible magnetic chitosan nanospheres (Fe3O4@CS) by a facile one-pot synthesis method. Doxorubicin (DOX, an anticancer drug) and indocyanine green (ICG) can be co-loaded into the Fe3O4@CS nanospheres (Fe3O4@CS-ICG/DOX nanocomposites) by virtue of the mesoporous structure and electrostatic interactions of CS. The fabricated nanocomposite showed excellent magnetic resonance imaging (MRI) and fluorescence imaging performances for tumors in vivo. Moreover, chemotherapy and photothermal therapy could be driven simultaneously under NIR laser irradiation. Tumor growth could be effectively inhibited by chemo-photothermal combinational therapy in vivo, achieving excellent synergistic therapeutic efficacy. That is, the proposed biocompatible Fe3O4@CS-ICG/DOX nanocomposites can be used as a kind of multifunctional nanoplatform for MRI and fluorescence imaging guided chemo-photothermal combination cancer therapy.
authors.affiliation: School of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai 201620, P. R. China. liuxijian@sues.edu.cn dr.lujie@foxmail.com.
authors.forename: Zhifang
authors.initials: Z
authors.lastname: Gao
authors.affiliation: School of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai 201620, P. R. China. liuxijian@sues.edu.cn dr.lujie@foxmail.com.
authors.forename: Xijian
authors.identifier: http://orcid.org/0000-0001-5856-9142
authors.initials: X
authors.lastname: Liu
authors.affiliation: School of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai 201620, P. R. China. liuxijian@sues.edu.cn dr.lujie@foxmail.com.
authors.forename: Yeying
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Orthopedic Traumatology, Trauma Center, Shanghai First People's Hospital, Shanghai Jiao Tong University School of Medicine, 100 Haining Road, Shanghai 200080, P. R. China.
authors.forename: Guoying
authors.initials: G
authors.lastname: Deng
authors.affiliation: Orthopedic Traumatology, Trauma Center, Shanghai First People's Hospital, Shanghai Jiao Tong University School of Medicine, 100 Haining Road, Shanghai 200080, P. R. China and First School of Clinical Medicine, Nanjing Medical University, Nanjing, 211166, P. R. China.
authors.forename: Feng
authors.initials: F
authors.lastname: Zhou
authors.affiliation: Orthopedic Traumatology, Trauma Center, Shanghai First People's Hospital, Shanghai Jiao Tong University School of Medicine, 100 Haining Road, Shanghai 200080, P. R. China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Wang
authors.affiliation: School of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai 201620, P. R. China. liuxijian@sues.edu.cn dr.lujie@foxmail.com.
authors.forename: Lijuan
authors.initials: L
authors.lastname: Zhang
authors.affiliation: School of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai 201620, P. R. China. liuxijian@sues.edu.cn dr.lujie@foxmail.com.
authors.forename: Jie
authors.initials: J
authors.lastname: Lu
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D048271:Chitosan / Q000737:chemistry*; D003131:Combined Modality Therapy; D052203:Ferrosoferric Oxide / Q000737:chemistry*; D064593:Heterografts; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D051379:Mice; D054118:Nanospheres; D009369:Neoplasms / Q000188:drug therapy / Q000628:therapy*; D010789:Phototherapy / Q000379:methods*; D013050:Spectrometry, Fluorescence / Q000379:methods*
chemical_list: D000970:Antineoplastic Agents; D048271:Chitosan; D052203:Ferrosoferric Oxide