title: Folic acid-modified and functionalized CuS nanocrystal-based nanoparticles for combined tumor chemo- and photothermal therapy.
abstract: Recent studies have identified that CuS nanocrystal (CuS NCs) could be used as a new class of promising photo-thermal agents due to their excellent plasmonic absorption abilities in a wide near-infrared (NIR) region. However, most of nanocarriers lack target capacity for combining chemotherapy and photothermal therapy effects. Herein, we reported chitosan (CS)-encapsulated and folic acid (FA)-modified nanoparticles (NPs) simultaneously loading with functionalized CuS NCs and docetaxel (DTX) (FA-DTX-PVP/CuS-NPs). Compared with free DTX, the photothermal agent CuS NCs and DTX not only could be specially targeted to deliver into MCF-7 cancer cells via a receptor-mediated endocytosis pathway, but also could be effectively transferred into tumor tissues of S180tumor-bearing mice in vivo. More important, when combination with NIR laser irradiation, FA-DTX-PVP/CuS-NPs showed a higher antitumor efficacy than the individual therapies. Thus, as a remote and noninvasive tumor therapy strategy, these active targeting NPs may provide a great potential for tumor synergistic therapy.
authors.affiliation: a School of Pharmaceutical Sciences , Henan University of Chinese Medicine , Zhengzhou , PR China.|b School of Pharmaceutical Sciences , Zhengzhou University , Zhengzhou , PR China.
authors.forename: Xiali
authors.initials: X
authors.lastname: Zhu
authors.affiliation: b School of Pharmaceutical Sciences , Zhengzhou University , Zhengzhou , PR China.
authors.forename: Yingjie
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: b School of Pharmaceutical Sciences , Zhengzhou University , Zhengzhou , PR China.
authors.forename: Heqing
authors.initials: H
authors.lastname: Huang
authors.affiliation: b School of Pharmaceutical Sciences , Zhengzhou University , Zhengzhou , PR China.
authors.forename: Huijuan
authors.initials: H
authors.lastname: Zhang
authors.affiliation: b School of Pharmaceutical Sciences , Zhengzhou University , Zhengzhou , PR China.|c Collaborative Innovation Center of New Drug Research and Safety Evaluation , Zhengzhou , PR China.
authors.forename: Lin
authors.initials: L
authors.lastname: Hou
authors.affiliation: b School of Pharmaceutical Sciences , Zhengzhou University , Zhengzhou , PR China.|c Collaborative Innovation Center of New Drug Research and Safety Evaluation , Zhengzhou , PR China.
authors.forename: Zhenzhong
authors.initials: Z
authors.lastname: Zhang
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D017209:Apoptosis; D001943:Breast Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000628:therapy*; D005260:Female; D005492:Folic Acid / Q000737:chemistry*; D006801:Humans; D061986:MCF-7 Cells; D051379:Mice; D008807:Mice, Inbred BALB C; D008855:Microscopy, Electron, Scanning; D053758:Nanoparticles; D010789:Phototherapy
chemical_list: D000970:Antineoplastic Agents; D005492:Folic Acid
keywords: CuS nanocrystal; docetaxel; folic acid; nanoparticle; photothermal therapy