title: Update on Burkitt Lymphoma.
abstract: Because of its rarity and high curability, progress in advancing therapeutics in Burkitt lymphoma (BL) has been difficult. Over recent years, several new mutations that cooperate with MYC have been identified, and this has paved the way for testing novel agents in the disease. One of the challenges of most standard approaches typically used is severe treatment-related toxicity that often leads to discontinuation of therapy. To that point, there has been recent success developing intermediate intensity approaches that are well tolerated in all patient groups and maintain high cure rates in a multicenter setting.
authors.affiliation: Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA. Electronic address: dunleavk@mail.nih.gov.
authors.forename: Kieron
authors.initials: K
authors.lastname: Dunleavy
authors.affiliation: HIV and Stem Cell Therapeutics, Cancer Therapeutic Evaluation Program (CTEP), National Cancer Institute, Bethesda, MD 20892, USA.
authors.forename: Richard F
authors.initials: RF
authors.lastname: Little
authors.affiliation: Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.
authors.forename: Wyndham H
authors.initials: WH
authors.lastname: Wilson
mesh_terms: D002051:Burkitt Lymphoma / Q000235:genetics / Q000378:metabolism / Q000628:therapy; D006801:Humans; D009154:Mutation; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics / Q000378:metabolism
chemical_list: C489427:MYC protein, human; D016271:Proto-Oncogene Proteins c-myc
keywords: Burkitt lymphoma; CCND3; Endemic; ID3; MYC; Risk-adapted; Sporadic; TCF3