title: Influence of Anatomical Detail and Tissue Conductivity Variations in Simulations of Multi-Contact Nerve Cuff Recordings.
abstract: Accurate simulations of peripheral nerve recordings are needed to develop improved neuroprostheses. Previous models of peripheral nerves contained simplifications whose effects have not been investigated. We created a novel detailed finite element (FE) model of a peripheral nerve, and used it to carry out a sensitivity analysis of several model parameters. To construct the model, in vivo recordings were obtained in a rat sciatic nerve using an 8-channel nerve cuff electrode, after which the nerve was imaged using magnetic resonance imaging (MRI). The FE model was constructed based on the MRI data, and included progressive branching of the fascicles. Neural pathways were defined in the model for the tibial, peroneal and sural fascicles. The locations of these pathways were selected so as to maximize the correlations between the simulated and in vivo recordings. The sensitivity analysis showed that varying the conductivities of neural tissues had little influence on the ability of the model to reproduce the recording patterns obtained experimentally. On the other hand, the increased anatomical detail did substantially alter the recording patterns observed, demonstrating that incorporating fascicular branching is an important consideration in models of nerve cuff recordings. The model used in this study constitutes an improved simulation tool and can be used in the design of neural interfaces.
authors.forename: Purbasha
authors.initials: P
authors.lastname: Garai
authors.forename: Ryan G L
authors.initials: RGL
authors.lastname: Koh
authors.forename: Martin
authors.initials: M
authors.lastname: Schuettler
authors.forename: Thomas
authors.initials: T
authors.lastname: Stieglitz
authors.forename: Jose
authors.initials: J
authors.lastname: Zariffa
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D003198:Computer Simulation; D004553:Electric Conductivity; D004567:Electrodes, Implanted; D004568:Electrodiagnosis / Q000295:instrumentation* / Q000379:methods; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006801:Humans; D008959:Models, Neurological; D051381:Rats; D020318:Rats, Long-Evans; D015203:Reproducibility of Results; D012584:Sciatic Nerve / Q000033:anatomy & histology* / Q000502:physiology*; D012680:Sensitivity and Specificity