title: Intraocular Pressure Measurements After Descemet Membrane Endothelial Keratoplasty.
abstract: OBJECTIVE
  Intraocular pressure (IOP) elevation occurs regularly after Descemet membrane endothelial keratoplasty (DMEK). This study evaluated the effect of central corneal thickness (CCT) on the IOP after DMEK.
  
  
  METHODS
  This prospective study recorded the IOP of 46 eyes from 46 patients preoperatively, and then 1 and 3 months after DMEK. IOP measurement was performed by noncontact pneumatic tonometry (NCT), iCare, Goldmann applanation tonometry (GAT), and dynamic contour tonometry (DCT). CCT was analyzed by anterior-segment optical coherence tomography.
  
  
  RESULTS
  Mean IOPs as measured by NCT, iCare, GAT, and DCT, respectively, were 14.3, 11.6, 12.7, and 16.0 mm Hg preoperatively; 13.1, 12.6, 12.7, and 16.0 mm Hg after 1 month; and 14.7, 14.5, 12.9, and 17.7 mm Hg after 3 months. There was a correlation of IOP measurements between GAT and NCT (P=0.119), GAT and iCare (P=0.892), and iCare and NCT (P=0.081) after 1 month and between iCare and NCT (P=0.702) after 3 months. Although GAT recorded approximately stable IOP values, NCT, iCare, and DCT tended to measure a higher IOP postoperatively than preoperatively. Preoperatively, correlations between IOP and CCT were not statistically significant for any measurement technique. After 3 months, the IOP measured by NCT and iCare correlated significantly with CCT (P=0.003, 0.041).
  
  
  CONCLUSIONS
  Correlation between the different measurement techniques was poor and showed a broad distribution of limits of agreement. Therefore, a change between the 4 techniques during follow-up is not recommended. Nevertheless, all techniques detected the IOP elevation during follow-up, requiring therapy.
authors.affiliation: Department of Ophthalmology, Charité-Universitätsmedizin Berlin, Germany.
authors.forename: Anna-Karina
authors.initials: AK
authors.lastname: Maier
authors.forename: Enken
authors.initials: E
authors.lastname: Gundlach
authors.forename: Milena
authors.initials: M
authors.lastname: Pahlitzsch
authors.forename: Johannes
authors.initials: J
authors.lastname: Gonnermann
authors.forename: Caitlin
authors.initials: C
authors.lastname: Corkhill
authors.forename: Eckart
authors.initials: E
authors.lastname: Bertelmann
authors.forename: Antonia M
authors.initials: AM
authors.lastname: Joussen
authors.forename: Matthias K J
authors.initials: MK
authors.lastname: Klamann
authors.forename: Necip
authors.initials: N
authors.lastname: Torun
mesh_terms: D000328:Adult; D000368:Aged; D003315:Cornea / Q000033:anatomy & histology*; D003886:Descemet Membrane / Q000601:surgery; D057111:Descemet Stripping Endothelial Keratoplasty / Q000009:adverse effects*; D005260:Female; D005901:Glaucoma / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D011446:Prospective Studies; D041623:Tomography, Optical Coherence; D014065:Tonometry, Ocular / Q000379:methods