title: CONSTANCES: a general prospective population-based cohort for occupational and environmental epidemiology: cohort profile.
abstract: WHY THE COHORT WAS SET UP?: CONSTANCES is a general-purpose cohort with a focus on occupational and environmental factors.
  
  
  
  CONSTANCES was designed as a randomly selected sample of French adults aged 18-69 years at inception; 200 000 participants will be included.
  
  
  
  At enrolment, the participants are invited to complete questionnaires and to attend a health screening centre (HSC) for a health examination. A biobank will be set up. The follow-up includes an yearly self-administered questionnaire, a periodic visit to an HSC and linkage to social and national health administrative databases.
  
  
  
  Data collected for participants include social and demographic characteristics, socioeconomic status, life events and behaviours. Regarding occupational and environmental factors, a wealth of data on organisational, chemical, biological, biomechanical and psychosocial lifelong exposure, as well as residential characteristics, are collected at enrolment and during follow-up. The health data cover a wide spectrum: self-reported health scales, reported prevalent and incident diseases, long-term chronic diseases and hospitalisations, sick-leaves, handicaps, limitations, disabilities and injuries, healthcare usage and services provided, and causes of death.
  
  
  
  To take into account non-participation and attrition, a random cohort of non-participants was set up and will be followed through the same national databases as participants.
  
  
  
  Inclusions begun at the end of 2012 and more than 110 000 participants were already included by September 2016. Several projects on occupational and environmental risks already applied to a public call for nested research projects.
authors.affiliation: Population-based Epidemiological Cohorts Unit, INSERM UMS 11, Villejuif, France.|Paris Descartes University, Paris, France.
authors.forename: Marcel
authors.initials: M
authors.lastname: Goldberg
authors.affiliation: Population-based Epidemiological Cohorts Unit, INSERM UMS 11, Villejuif, France.
authors.forename: Matthieu
authors.initials: M
authors.lastname: Carton
authors.affiliation: Population-based Epidemiological Cohorts Unit, INSERM UMS 11, Villejuif, France.|Occupational Health Unit, Raymond Poincaré Hospital, Garches, France.
authors.forename: Alexis
authors.initials: A
authors.lastname: Descatha
authors.affiliation: Population-based Epidemiological Cohorts Unit, INSERM UMS 11, Villejuif, France.
authors.forename: Annette
authors.initials: A
authors.lastname: Leclerc
authors.affiliation: LEEST, Medical School, Angers University, Angers, France.
authors.forename: Yves
authors.initials: Y
authors.lastname: Roquelaure
authors.affiliation: Population-based Epidemiological Cohorts Unit, INSERM UMS 11, Villejuif, France.
authors.forename: Gaëlle
authors.initials: G
authors.lastname: Santin
authors.affiliation: Population-based Epidemiological Cohorts Unit, INSERM UMS 11, Villejuif, France.|Paris Descartes University, Paris, France.
authors.forename: Marie
authors.initials: M
authors.lastname: Zins
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D018070:Biological Specimen Banks; D002908:Chronic Disease / Q000453:epidemiology; D015331:Cohort Studies; D016208:Databases, Factual; D004781:Environmental Exposure / Q000009:adverse effects / Q000032:analysis; D004812:Epidemiologic Methods; D005260:Female; D005602:France / Q000453:epidemiology; D062305:Geographic Mapping; D006801:Humans; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000453:epidemiology*; D016273:Occupational Exposure; D011446:Prospective Studies; D012307:Risk Factors; D011795:Surveys and Questionnaires; D055815:Young Adult
keywords: Aging; Chronic diseases; Occupational epidemiology; Population-based cohort