title: Selank Inhibits Ethanol-Induced Hyperlocomotion and Manifestation of Behavioral Sensitization in DBA/2 Mice.
abstract: The effect of non-benzodiazepine anxiolytics on the ethanol-induced hyperlocomotion and behavioral sensitization was assessed in male DBA/2 mice. Selank that enhances activity of the endogenous opioid system (0.3 mg/kg, intraperitoneally), similar to the nonselective opiate receptor blocker naloxone (1.0 mg/kg, intraperitoneally), prevented the development of ethanol-induced (2.0 g/kg intraperitoneally) hyperlocomotion, in contrast to σ1-receptors agonist Afobazole (1.0 mg/kg, intraperitoneally) that did not inhibit ethanol-induced behavioral stimulation. Single dose of Selank significantly blocked manifestation of motor sensitization without affecting its formation. These findings suggest that Selank can modulate the motivational effects of ethanol.
authors.affiliation: V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia. lgkolik@mail.ru.
authors.forename: L G
authors.initials: LG
authors.lastname: Kolik
authors.affiliation: V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Nadorova
authors.affiliation: V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia.
authors.forename: S B
authors.initials: SB
authors.lastname: Seredenin
mesh_terms: D017109:Akathisia, Drug-Induced / Q000188:drug therapy* / Q000503:physiopathology; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001522:Behavior, Animal; D001562:Benzimidazoles / Q000494:pharmacology; D000431:Ethanol / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D009025:Morpholines / Q000494:pharmacology; D009270:Naloxone / Q000494:pharmacology; D009292:Narcotic Antagonists / Q000494:pharmacology; D009842:Oligopeptides / Q000494:pharmacology*; D011595:Psychomotor Agitation / Q000188:drug therapy* / Q000503:physiopathology; D011957:Receptors, Opioid / Q000819:agonists / Q000378:metabolism*
chemical_list: C410924:2-((2-morpholino)ethylthio)-5-ethoxybenzimidazole; D014151:Anti-Anxiety Agents; D001562:Benzimidazoles; D009025:Morpholines; D009292:Narcotic Antagonists; D009842:Oligopeptides; D011957:Receptors, Opioid; D009270:Naloxone; D000431:Ethanol; C100827:TP 7
keywords: DBA/2 mice; Selank; behavioral sensitization; ethanol; hyperlocomotion