title: Mucosal melanoma of the upper airways tract mucosal melanoma: A systematic review with meta-analyses of treatment.
abstract: Mucosal melanoma of the upper aerodigestive tract (MM-UADT) occurs in a complex anatomic region. It represents a small number of tumors of the head and neck and a small number of melanoma cases.
  
  
  
  Search strategies initially identified 600, 11 of which were included in this study.
  
  
  
  All studies involved surgery and radiotherapy. None were randomized, and all were assessed as having a high risk of selection and performance bias. No studies reported quality of life, treatment-related mortality, or morbidity. The results indicate that the addition of radiotherapy to surgery reduces the rate of locoregional recurrence (hazard ratio [HR], 0.60; 95% confidence interval [CI], 0.42-0.87). There was no statistically significant difference in overall survival (HR, 1.16; 95% CI, 0.98-1.37).
  
  
  
  Surgical resection with postoperative radiotherapy remains the optimal treatment strategy for locoregional control. More robust studies and the use of molecular targeted therapies need to be undertaken to improve overall survival. © 2016 Wiley Periodicals, Inc. Head Neck 39: 819-825, 2017.
authors.affiliation: National Collaborating Centre for Cancer, Park House, Cardiff, United Kingdom.
authors.forename: David
authors.initials: D
authors.lastname: Jarrom
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, Newcastle upon Tyne Hospitals NHS Trust, Newcastle upon Tyne, United Kingdom.|Department of Head and Neck Surgery, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, United Kingdom.
authors.forename: Vinidh
authors.initials: V
authors.lastname: Paleri
authors.affiliation: Department of Maxillofacial / Head and Neck Surgery, The Royal Marsden Hospital, Greater London, United Kingdom.
authors.forename: Cyrus
authors.initials: C
authors.lastname: Kerawala
authors.affiliation: Department of Clinical Oncology, Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, United Kingdom.
authors.forename: Thomas
authors.initials: T
authors.lastname: Roques
authors.affiliation: Department of Clinical Oncology, The Royal Marsden Hospital NHS Foundation Trust, Sutton, Surrey, United Kingdom.
authors.forename: Shreerang
authors.initials: S
authors.lastname: Bhide
authors.affiliation: Department of Maxillofacial / Head and Neck Surgery, The Queen Victoria Hospital NHS Foundation Trust, East Grinstead, West Sussex, United Kingdom.
authors.forename: Laurence
authors.initials: L
authors.lastname: Newman
authors.affiliation: Department of ENT Surgery, Oxford University NHS Trusts, Oxford, United Kingdom.
authors.forename: Stuart C
authors.initials: SC
authors.lastname: Winter
mesh_terms: D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D005260:Female; D006258:Head and Neck Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000473:pathology* / Q000628:therapy*; D006801:Humans; D007820:Laryngeal Mucosa / Q000473:pathology; D008297:Male; D008545:Melanoma / Q000175:diagnosis / Q000401:mortality / Q000473:pathology* / Q000628:therapy*; D009061:Mouth Mucosa / Q000473:pathology; D011379:Prognosis; D018714:Radiotherapy, Adjuvant; D020545:Respiratory Mucosa / Q000473:pathology / Q000601:surgery; D018570:Risk Assessment; D013514:Surgical Procedures, Operative / Q000379:methods; D016019:Survival Analysis
keywords: melanoma; radiotherapy; sinonasal; surgery