title: Cognitive Dysfunction and Malnutrition Are Independent Predictor of Dysphagia in Patients with Acute Exacerbation of Congestive Heart Failure.
abstract: Early detection and intervention for dysphagia is important in patients with congestive heart failure (CHF). However, previous studies have focused on how many patients with dysphagia develop CHF. Studies focusing on the comorbidity of dysphagia in patients with CHF are rare. Additionally, risk factors for dysphagia in patients with CHF are unclear. Thus, the aim of this study was to clarify risk factors for dysphagia in patients with acute exacerbation of CHF. A total of 105 patients, who were admitted with acute exacerbation of CHF, were enrolled. Clinical interviews, blood chemistry analysis, electrocardiography, echocardiography, Mini-Mental State Examination (MMSE), exercise tolerance tests, phonatory function tests, and evaluation of activities of daily living (ADL) and nutrition were conducted on admission. After attending physicians permitted the drinking of water, swallowing screening tests were performed. Patients were divided into a dysphagia group (DG) or a non-dysphagia group (non-DG) based on Functional Oral Intake Scale level. Among the 105 patients, 38 had dysphagia. A greater number of patients had history of aspiration pneumonia and dementia, and there was a higher age, N-terminal pro-B-type natriuretic peptide level in the DG compared with the non-DG. MMSE scores, exercise tolerance, phonatory function, status of ADL, nutrition, albumin, and transthyretin were lower in the DG compared with the non-DG. In multivariate analysis, after adjusting for age and sex, MMSE, BI score, and transthyretin was independently associated with dysphagia. Comorbidity of dysphagia was 36.1% in patients with acute exacerbation of CHF, and cognitive dysfunction and malnutrition may be an independent predictor of dysphagia.
authors.affiliation: Department of Internal Medicine and Rehabilitation Science, Tohoku University Graduate School of Medicine, Sendai, Japan.|Department of Rehabilitation, Sendai Medical Center, Sendai, Japan.
authors.forename: Junichi
authors.initials: J
authors.lastname: Yokota
authors.affiliation: Department of Sport and Medical Sciences, Faculty of Medical Technology, Teikyo University, Tokyo, Japan.
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Ogawa
authors.affiliation: Department of Cardiology, Sendai Medical Center, Sendai, Japan.
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Yamanaka
authors.affiliation: Department of Cardiology, Sendai Medical Center, Sendai, Japan.
authors.forename: Yoshimi
authors.initials: Y
authors.lastname: Takahashi
authors.affiliation: Department of Cardiology, Sendai Medical Center, Sendai, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Fujita
authors.affiliation: Department of Cardiology, Sendai Medical Center, Sendai, Japan.
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Yamaguchi
authors.affiliation: Department of Cardiology, Sendai Medical Center, Sendai, Japan.
authors.forename: Noriko
authors.initials: N
authors.lastname: Onoue
authors.affiliation: Department of Cardiology, Sendai Medical Center, Sendai, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Ishizuka
authors.affiliation: Department of Cardiology, Sendai Medical Center, Sendai, Japan.
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Shinozaki
authors.affiliation: Department of Internal Medicine and Rehabilitation Science, Tohoku University Graduate School of Medicine, Sendai, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kohzuki
mesh_terms: D000203:Activities of Daily Living; D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D001774:Blood Chemical Analysis; D016022:Case-Control Studies; D060825:Cognitive Dysfunction / Q000150:complications*; D003679:Deglutition; D003680:Deglutition Disorders / Q000175:diagnosis* / Q000209:etiology; D004452:Echocardiography; D015444:Exercise; D005260:Female; D006333:Heart Failure / Q000150:complications / Q000473:pathology*; D006801:Humans; D007407:Interviews as Topic; D008297:Male; D044342:Malnutrition / Q000150:complications*; D020097:Natriuretic Peptide, Brain / Q000097:blood; D011228:Prealbumin / Q000032:analysis; D012307:Risk Factors; D012709:Serum Albumin / Q000032:analysis; D012720:Severity of Illness Index
chemical_list: D011228:Prealbumin; D012709:Serum Albumin; D020097:Natriuretic Peptide, Brain