title: Sonochemical synthesis of highly branched flower-like Fe3O4@SiO2@Ag microcomposites and their application as versatile SERS substrates.
abstract: We report a novel strategy for the synthesis of magnetic-based flower-like silver composite microspheres (Fe3O4@SiO2@Ag microflowers) with a highly branched shell structure through a sonochemical-assisted method. The obtained Fe3O4@SiO2@Ag microflowers possess good dispersity, high magnetic responsiveness, and highly reproducible structures. The size and morphology of the silver petal shell of these microflowers can be easily controlled by varying the experimental parameters. The silver petal provides an effectively large surface area for forming sufficient plasmonic hot spots and capturing target molecules. The microscale magnetic core endows microflowers with superior magnetic nature to enrich targeted analytes and create abundant interparticle hot spots through magnetism-induced aggregation. Hence, Fe3O4@SiO2@Ag microflowers could be a versatile SERS substrate, as verified by the detection of the non-adsorbed R6G molecules and the adsorbed pesticide thiram, with a detection limit as low as 1 × 10-14M and 1 × 10-11M, respectively. We further demonstrate that aptamer-functionalized microflowers can easily capture S. aureus in tap water and significantly enhance their SERS signal. Moreover, the microflowers can be easily recycled because of the intrinsic magnetism of the Fe3O4cores, which indicate a new route in eliminating the "single-use" problem of traditional SERS substrates. These advantages make the microflowers powerful SERS probes for chemical and biological analyses.
authors.affiliation: Beijing Institute of Radiation Medicine, Beijing 100850, PR China. ruixiao203@sina.com sqwang@bmi.ac.cn and College of Life Sciences & Bio-Engineering, Beijing University of Technology, Beijing 100124, PR China.
authors.forename: Chongwen
authors.initials: C
authors.lastname: Wang
authors.affiliation: Beijing Institute of Radiation Medicine, Beijing 100850, PR China. ruixiao203@sina.com sqwang@bmi.ac.cn and College of Mechatronics and Automation, National University of Defense Technology, Changsha, Hunan 410073, PR China.
authors.forename: Junfeng
authors.initials: J
authors.lastname: Wang
authors.affiliation: Beijing Institute of Radiation Medicine, Beijing 100850, PR China. ruixiao203@sina.com sqwang@bmi.ac.cn.
authors.forename: Ping
authors.initials: P
authors.lastname: Li
authors.affiliation: Beijing Institute of Radiation Medicine, Beijing 100850, PR China. ruixiao203@sina.com sqwang@bmi.ac.cn.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Rong
authors.affiliation: Beijing Institute of Radiation Medicine, Beijing 100850, PR China. ruixiao203@sina.com sqwang@bmi.ac.cn and College of Life Sciences & Bio-Engineering, Beijing University of Technology, Beijing 100124, PR China.
authors.forename: Xiaofei
authors.initials: X
authors.lastname: Jia
authors.affiliation: Beijing Institute of Radiation Medicine, Beijing 100850, PR China. ruixiao203@sina.com sqwang@bmi.ac.cn.
authors.forename: Qiuling
authors.initials: Q
authors.lastname: Ma
authors.affiliation: Beijing Institute of Radiation Medicine, Beijing 100850, PR China. ruixiao203@sina.com sqwang@bmi.ac.cn.
authors.forename: Rui
authors.initials: R
authors.lastname: Xiao
authors.affiliation: Beijing Institute of Radiation Medicine, Beijing 100850, PR China. ruixiao203@sina.com sqwang@bmi.ac.cn and College of Life Sciences & Bio-Engineering, Beijing University of Technology, Beijing 100124, PR China.
authors.forename: Shengqi
authors.initials: S
authors.lastname: Wang