title: The potential hazard of drug-eluting stent-induced coronary vasospasm causing subacute stent thrombosis: a case report.
abstract: Drug-eluting stent (DES) -induced coronary vasospasm is a well known phenomenon after stent implantation; however, the extent of this risk is still unknown. We report a case in which DES-induced severe coronary vasospasm was clinically suspected as a cause of subacute stent thrombosis (ST).
  
  
  
  A 67-year-old man came to our hospital due to chest pain with mild exercise. He was diagnosed with effort angina by coronary angiography and underwent DES implantation in the mid-left ascending artery (LAD) after the administration of dual anti-platelet therapy. The procedure was uneventful, but his symptoms changed from effort angina to rest angina after stenting. Five days after the procedure, subacute ST occurred, requiring aspiration thrombectomy and balloon angioplasty. Thereafter, he continued to report early morning chest discomfort. We performed a spasm provocation test to evaluate the coronary vasomotor response; it revealed severe stent-edge spasm in the left main trunk to the LAD, except for the stented lesion, and total occlusion of the left circumflex artery.
  
  
  
  To our knowledge, the present case is the first report describing in-stent thrombosis secondary to stent-edge spasm. This case describes the potential hazard of DES-induced coronary vasospasm. Although there are several overlapping risk factors for ST development, we consider that stent-edge spasm also plays an important role in ST development. Therefore, we should monitor new-onset rest angina after stent implantation and carefully assess DES-induced coronary vasospasm.
authors.affiliation: Division of Cardiology, Osaka Saiseikai Izuo Hospital, 3-4-5 Kitayama, Taisho-ku, Osaka, 551-0032, Japan. hs.vxvii@gmail.com.
authors.forename: Hiroki
authors.identifier: 0000-0002-3593-3981
authors.initials: H
authors.lastname: Shibutani
authors.affiliation: Division of Cardiology, Osaka Saiseikai Izuo Hospital, 3-4-5 Kitayama, Taisho-ku, Osaka, 551-0032, Japan.
authors.forename: Yuzo
authors.initials: Y
authors.lastname: Akita
authors.affiliation: Division of Cardiology, Osaka Saiseikai Izuo Hospital, 3-4-5 Kitayama, Taisho-ku, Osaka, 551-0032, Japan.
authors.forename: Yumie
authors.initials: Y
authors.lastname: Matsui
authors.affiliation: Division of Cardiology, Osaka Saiseikai Izuo Hospital, 3-4-5 Kitayama, Taisho-ku, Osaka, 551-0032, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Yoshinaga
authors.affiliation: Division of Cardiology, Osaka Saiseikai Izuo Hospital, 3-4-5 Kitayama, Taisho-ku, Osaka, 551-0032, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Karakawa
mesh_terms: D000208:Acute Disease; D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000379:methods; D017023:Coronary Angiography; D003329:Coronary Vasospasm / Q000150:complications* / Q000175:diagnosis; D003331:Coronary Vessels / Q000000981:diagnostic imaging* / Q000503:physiopathology; D054855:Drug-Eluting Stents / Q000009:adverse effects*; D006083:Graft Occlusion, Vascular / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D006801:Humans; D008297:Male; D012307:Risk Factors; D017131:Thrombectomy / Q000379:methods; D018084:Ultrasonography, Interventional
keywords: Effort angina; In-stent thrombosis; Percutaneous coronary intervention; Stent-edge spasm; Vasospastic angina