title: Quercetin loading CdSe/ZnS nanoparticles as efficient antibacterial and anticancer materials.
abstract: Quercetin (Qe) plays an important role in inflammation, antibacterial, anticancer, and aging. However, Qe has extremely low water solubility, which is a major challenge in drug absorption. In this study, we described a simple method for synthesis of Qe/CdSe/ZnS nanoparticles (QCZ NPs). The QCZ NPs had an average diameter of 10nm and prominent yellow emission under UV irradiation. We investigated the antibacterial activity of QCZ NPs against drug-resistant Escherichia coli (E. coli) and Bacillus subtilis (B. subtilis) in vitro. Results showed that QCZ NPs had considerably more effective antibacterial activities than Qe or CdSe nanoparticles (CdSe NPs). Antibacterial experiment results showed that QCZ NPs acted against E. coli and B. subtilis by disrupting the bacterial cell wall and membrane. In vivo study, the QCZ NPs could cure inflammation and lesion which caused by E. coli. In anticancer assays, the MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] cell proliferation assays exhibited the cytotoxicity of QCZ NPs increased approximately 2-6 fold compared to raw Qe and CdSe NPs. Moreover, by using RT-CES (real-time cell electronic sensing) studies, we had demonstrated QCZ NPs have also an effect on migration and proliferation of BGC-823 cells. CdSe NPs loaded with Qe, these QCZ NPs exhibited excellent antibacterial (E. coli and B. subtilis) and anticancer (BGC-823) activities.
authors.affiliation: School of life sciences, Anhui Agricultural University, Hefei 230036, China.
authors.forename: Xiaofang
authors.initials: X
authors.lastname: Yang
authors.affiliation: School of life sciences, Anhui Agricultural University, Hefei 230036, China.
authors.forename: Weiwei
authors.initials: W
authors.lastname: Zhang
authors.affiliation: School of life sciences, Anhui Agricultural University, Hefei 230036, China.
authors.forename: Zhiwei
authors.initials: Z
authors.lastname: Zhao
authors.affiliation: School of life sciences, Anhui Agricultural University, Hefei 230036, China.
authors.forename: Nuan
authors.initials: N
authors.lastname: Li
authors.affiliation: School of life sciences, Anhui Agricultural University, Hefei 230036, China.
authors.forename: Zhipeng
authors.initials: Z
authors.lastname: Mou
authors.affiliation: School of life sciences, Anhui Agricultural University, Hefei 230036, China.
authors.forename: Dongdong
authors.initials: D
authors.lastname: Sun
authors.affiliation: School of life sciences, Anhui Agricultural University, Hefei 230036, China.
authors.forename: Yongping
authors.initials: Y
authors.lastname: Cai
authors.affiliation: School of life sciences, Anhui Agricultural University, Hefei 230036, China.
authors.forename: Weiyun
authors.initials: W
authors.lastname: Wang
authors.affiliation: School of life sciences, Anhui Agricultural University, Hefei 230036, China. Electronic address: linyi1616@126.com.
authors.forename: Yi
authors.initials: Y
authors.lastname: Lin
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000494:pharmacology; D001419:Bacteria / Q000254:growth & development*; D019187:Cadmium Compounds / Q000494:pharmacology; D005260:Female; D006367:HeLa Cells; D006801:Humans; D061986:MCF-7 Cells; D051379:Mice; D008819:Mice, Nude; D053758:Nanoparticles / Q000737:chemistry*; D009374:Neoplasms, Experimental / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D011794:Quercetin / Q000737:chemistry / Q000494:pharmacology; D018036:Selenium Compounds / Q000494:pharmacology; D013440:Sulfides / Q000737:chemistry / Q000494:pharmacology; D023041:Xenograft Model Antitumor Assays; D017967:Zinc Compounds / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D019187:Cadmium Compounds; D018036:Selenium Compounds; D013440:Sulfides; D017967:Zinc Compounds; D011794:Quercetin; C058667:cadmium selenide; C031238:zinc sulfide
keywords: Antibacterial; Anticancer; CdSe/ZnS nanoparticles; Drug-resistant; Fluorescence; Quercetin