title: Fibroblast Growth Factor Receptor 1 Gene Amplification in Nonsmall Cell Lung Cancer.
abstract: OBJECTIVE
  To review the prevalence and prognostic significance of fibroblast growth factor receptor 1 (FGFR1) amplification and to establish an association between FGFR1 amplification and the clinical characteristics of nonsmall cell lung cancer (NSCLC).
  
  
  METHODS
  We searched PubMed for English-language studies published between January 2010 and May 2016.
  
  
  METHODS
  We included all relevant articles, with no limitation of study design.
  
  
  RESULTS
  FGFR1 amplification was reported in 8.7-20.0% of NSCLC cases and was significantly more frequent in squamous cell carcinomas (SCCs) (9.7-28.3%) than in adenocarcinomas (ADCs) (0-15.0%). The rates of FGFR1 amplification were as follows: males, 13.9-22.1%; females, 0-20.1%; Stage I NSCLC, 9.3-24.1%; Stage II NSCLC, 12.9-25.0%; Stage III NSCLC, 8.2-19.5%; Stage IV NSCLC, 0-12.5%; current smokers, 13.3-29.0%; former smokers, 2.5-23.0%; and nonsmokers, 0-22.2%. Overall survival was 43.9-70.8 months in patients with FGFR1 amplification and 42.4-115.0 months in patients with no FGFR1 amplification; disease-free survival was 22.5-58.5 months and 52.4-94.6 months, respectively.
  
  
  CONCLUSIONS
  FGFR1 amplification is more frequent in SCCs than in ADCs. The association between FGFR1 amplification and clinical characteristics (gender, smoking status, and disease stage) and the prognostic significance of FGFR1 amplification in NSCLC remain controversial.
authors.affiliation: Department of Respiratory Medicine, Shandong Jining No. 1 People's Hospital, Jining, Shandong 272000, China.
authors.forename: Jian-Long
authors.initials: JL
authors.lastname: Miao
authors.affiliation: Department of Respiratory Medicine, Shandong Jining No. 1 People's Hospital, Jining, Shandong 272000, China.
authors.forename: Rui-Juan
authors.initials: RJ
authors.lastname: Liu
authors.affiliation: Department of Respiratory Medicine, Shandong Jining No. 1 People's Hospital, Jining, Shandong 272000, China.
authors.forename: Jin-Hua
authors.initials: JH
authors.lastname: Zhou
authors.affiliation: Zouping County Institute for Tuberculosis Prevention and Control, Binzhou, Shandong 256200, China.
authors.forename: Shu-Hua
authors.initials: SH
authors.lastname: Meng
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics / Q000401:mortality / Q000473:pathology; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000401:mortality / Q000473:pathology; D018572:Disease-Free Survival; D005260:Female; D005784:Gene Amplification / Q000235:genetics*; D006801:Humans; D008297:Male; D051496:Receptor, Fibroblast Growth Factor, Type 1 / Q000235:genetics*
chemical_list: D051496:Receptor, Fibroblast Growth Factor, Type 1