title: Enabling the democratization of the genomics revolution with a fully integrated web-based bioinformatics platform.
abstract: Continued advancements in sequencing technologies have fueled the development of new sequencing applications and promise to flood current databases with raw data. A number of factors prevent the seamless and easy use of these data, including the breadth of project goals, the wide array of tools that individually perform fractions of any given analysis, the large number of associated software/hardware dependencies, and the detailed expertise required to perform these analyses. To address these issues, we have developed an intuitive web-based environment with a wide assortment of integrated and cutting-edge bioinformatics tools in pre-configured workflows. These workflows, coupled with the ease of use of the environment, provide even novice next-generation sequencing users with the ability to perform many complex analyses with only a few mouse clicks and, within the context of the same environment, to visualize and further interrogate their results. This bioinformatics platform is an initial attempt at Empowering the Development of Genomics Expertise (EDGE) in a wide range of applications for microbial research.
authors.affiliation: Bioscience Division, Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
authors.forename: Po-E
authors.initials: PE
authors.lastname: Li
authors.affiliation: Bioscience Division, Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
authors.forename: Chien-Chi
authors.initials: CC
authors.lastname: Lo
authors.affiliation: Defense Threat Reduction Agency, Fort Belvoir, VA 22060, USA.|Naval Medical Research Center-Frederick, Fort Detrick, MD 21702, USA.
authors.forename: Joseph J
authors.initials: JJ
authors.lastname: Anderson
authors.affiliation: Bioscience Division, Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
authors.forename: Karen W
authors.initials: KW
authors.lastname: Davenport
authors.affiliation: Naval Medical Research Center-Frederick, Fort Detrick, MD 21702, USA.|Henry M. Jackson Foundation, Bethesda, MD 20817, USA.
authors.forename: Kimberly A
authors.initials: KA
authors.lastname: Bishop-Lilly
authors.affiliation: Bioscience Division, Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
authors.forename: Yan
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Bioscience Division, Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
authors.forename: Sanaa
authors.initials: S
authors.lastname: Ahmed
authors.affiliation: Bioscience Division, Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
authors.forename: Shihai
authors.initials: S
authors.lastname: Feng
authors.affiliation: Naval Medical Research Center-Frederick, Fort Detrick, MD 21702, USA.
authors.forename: Vishwesh P
authors.initials: VP
authors.lastname: Mokashi
authors.affiliation: Bioscience Division, Los Alamos National Laboratory, Los Alamos, NM 87545, USA pchain@lanl.gov.
authors.forename: Patrick S G
authors.initials: PS
authors.lastname: Chain
mesh_terms: D000881:Anthrax / Q000382:microbiology; D001408:Bacillus anthracis / Q000145:classification* / Q000235:genetics; D019295:Computational Biology / Q000379:methods*; D029043:Ebolavirus / Q000145:classification* / Q000235:genetics; D004926:Escherichia coli / Q000145:classification* / Q000235:genetics; D004927:Escherichia coli Infections / Q000382:microbiology; D019142:Hemorrhagic Fever, Ebola / Q000821:virology; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans; D020407:Internet; D010802:Phylogeny; D010930:Plague / Q000382:microbiology; D012984:Software; D015010:Yersinia pestis / Q000145:classification* / Q000235:genetics