title: Separation of44Ti from proton irradiated scandium by using solid-phase extraction chromatography and design of44Ti/44Sc generator system.
abstract: Scandium-44g (half-life 3.97h [1]) shows promise for positron emission tomography (PET) imaging of longer biological processes than that of the current gold standard,18F, due to its favorable decay parameters. One source of44gSc is the long-lived parent nuclide44Ti (half-life 60.0 a). A44Ti/44gSc generator would have the ability to provide radionuclidically pure44gSc on a daily basis. The production of44Ti via the45Sc(p,2n) reaction requires high proton beam currents and long irradiation times. Recovery and purification of no-carrier added (nca)44Ti from scandium metal targets involves complex separation chemistry. In this study, separation systems based on solid phase extraction chromatography were investigated, including branched diglycolamide (BDGA) resin and hydroxamate based ZR resin. Results indicate that ZR resin in HCl media represents an effective44Ti/44gSc separation system.
authors.affiliation: Chemistry Division, Los Alamos National Laboratory, P.O. Box 1663, Los Alamos, NM 87545, USA.
authors.forename: V
authors.initials: V
authors.lastname: Radchenko
authors.affiliation: Chemistry Division, Los Alamos National Laboratory, P.O. Box 1663, Los Alamos, NM 87545, USA.
authors.forename: C A L
authors.initials: CAL
authors.lastname: Meyer
authors.affiliation: Chemistry Division, Los Alamos National Laboratory, P.O. Box 1663, Los Alamos, NM 87545, USA.
authors.forename: J W
authors.initials: JW
authors.lastname: Engle
authors.affiliation: Chemistry Division, Los Alamos National Laboratory, P.O. Box 1663, Los Alamos, NM 87545, USA.
authors.forename: C M
authors.initials: CM
authors.lastname: Naranjo
authors.affiliation: Chemistry Division, Los Alamos National Laboratory, P.O. Box 1663, Los Alamos, NM 87545, USA.
authors.forename: G A
authors.initials: GA
authors.lastname: Unc
authors.affiliation: Chemistry Division, Los Alamos National Laboratory, P.O. Box 1663, Los Alamos, NM 87545, USA.
authors.forename: T
authors.initials: T
authors.lastname: Mastren
authors.affiliation: Chemistry Division, Los Alamos National Laboratory, P.O. Box 1663, Los Alamos, NM 87545, USA.
authors.forename: M
authors.initials: M
authors.lastname: Brugh
authors.affiliation: Chemistry Division, Los Alamos National Laboratory, P.O. Box 1663, Los Alamos, NM 87545, USA.
authors.forename: E R
authors.initials: ER
authors.lastname: Birnbaum
authors.affiliation: Chemistry Division, Los Alamos National Laboratory, P.O. Box 1663, Los Alamos, NM 87545, USA.
authors.forename: K D
authors.initials: KD
authors.lastname: John
authors.affiliation: Chemistry Division, Los Alamos National Laboratory, P.O. Box 1663, Los Alamos, NM 87545, USA.
authors.forename: F M
authors.initials: FM
authors.lastname: Nortier
authors.affiliation: Chemistry Division, Los Alamos National Laboratory, P.O. Box 1663, Los Alamos, NM 87545, USA. Electronic address: mifa@lanl.gov.
authors.forename: M E
authors.initials: ME
authors.lastname: Fassbender
mesh_terms: D000577:Amides / Q000737:chemistry; D002845:Chromatography / Q000379:methods*; D006851:Hydrochloric Acid / Q000737:chemistry; D007700:Kinetics; D011522:Protons; D011868:Radioisotopes / Q000302:isolation & purification*; D012117:Resins, Synthetic / Q000737:chemistry; D012538:Scandium / Q000737:chemistry*; D052616:Solid Phase Extraction / Q000379:methods*; D012996:Solutions; D014025:Titanium / Q000302:isolation & purification*
chemical_list: D000577:Amides; D011522:Protons; D011868:Radioisotopes; D012117:Resins, Synthetic; D012996:Solutions; D014025:Titanium; D006851:Hydrochloric Acid; D012538:Scandium
keywords: (44)Ti; (44g)Sc; BDGA; Scandium metal target; Solid phase extraction chromatography; ZR resin