title: Synthesis, characterization and biological studies of Schiff bases derived from heterocyclic moiety.
abstract: Some new Schiff bases (H1-H7) have been synthesized by the condensation of 2-aminophenol, 2-amino-4-nitrophenol, 2-amino-4-methylphenol, 2-amino benzimidazole with thiophene-2-carboxaldehyde and pyrrole-2-carboxaldehyde. The structures of newly synthesized compounds were characterized by elemental analysis, FT-IR,1H NMR, UV-VIS, and single crystal X-ray crystallography. The in vitro antibacterial activity of the synthesized compounds has been tested against Salmonella typhi, Bacillus coagulans, Bacillus pumills, Escherichia coli, Bacillus circulans, Pseudomonas, Clostridium and Klebsilla pneumonia by disk diffusion method. The quantitative antimicrobial activity of the test compounds was evaluated using Resazurin based Microtiter Dilution Assay. Ampicillin was used as standard antibiotics. Schiff bases individually exhibited varying degrees of inhibitory effects on the growth of the tested bacterial species. The antioxidant activity of the synthesized compounds was determined by the 1,1-diphenyl-2-picrylhydrazyl(DPPH) method. IC50value of synthesized Schiff bases were calculated and compared with standard BHA.
authors.affiliation: Department of Applied Chemistry, Cochin University of Science and Technology, Kochi 22, Kerala, India.
authors.forename: Angamaly Antony
authors.initials: AA
authors.lastname: Shanty
authors.affiliation: Department of Applied Chemistry, Cochin University of Science and Technology, Kochi 22, Kerala, India.
authors.forename: Jessica Elizabeth
authors.initials: JE
authors.lastname: Philip
authors.affiliation: Department of Applied Chemistry, Cochin University of Science and Technology, Kochi 22, Kerala, India.
authors.forename: Eeettinilkunnathil Jose
authors.initials: EJ
authors.lastname: Sneha
authors.affiliation: Department of Applied Chemistry, Cochin University of Science and Technology, Kochi 22, Kerala, India.
authors.forename: Maliyeckal R
authors.initials: MR
authors.lastname: Prathapachandra Kurup
authors.affiliation: Department of Chemistry, M.G. College, Trivandrum, Kerala, India.
authors.forename: Sreedharannair
authors.initials: S
authors.lastname: Balachandran
authors.affiliation: Department of Applied Chemistry, Cochin University of Science and Technology, Kochi 22, Kerala, India.
authors.forename: Puzhavoorparambil Velayudhan
authors.initials: PV
authors.lastname: Mohanan
mesh_terms: D000447:Aldehydes / Q000737:chemistry / Q000494:pharmacology; D000627:Aminophenols / Q000737:chemistry / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D000975:Antioxidants / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000188:drug therapy; D003408:Cresols / Q000737:chemistry / Q000494:pharmacology; D018360:Crystallography, X-Ray; D055808:Drug Discovery; D006801:Humans; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D009596:Nitrophenols / Q000737:chemistry / Q000494:pharmacology; D011758:Pyrroles / Q000737:chemistry / Q000494:pharmacology; D012545:Schiff Bases / Q000737:chemistry* / Q000494:pharmacology*; D013876:Thiophenes / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000447:Aldehydes; D000627:Aminophenols; D000900:Anti-Bacterial Agents; D000975:Antioxidants; D003408:Cresols; D009596:Nitrophenols; D011758:Pyrroles; D012545:Schiff Bases; D013876:Thiophenes; C051266:pyrrole-2-carboxaldehyde; C027667:2-aminophenol; C073225:2-amino-4-methylphenol; C036645:2-amino-4-nitrophenol; C509177:thiophene-2-carboxaldehyde
keywords: Amines; Antibacterial activity; Antioxidant activity; Heterocyclic aldehydes; Schiff bases; Spectral studies