title: Anti-hyperlipidemia and antioxidant activities of Amygdalus pedunculata seed oil.
abstract: This study attempts to evaluate the beneficial effects of Amygdalus pedunculata seed oil (AO) on the lipid profile and antioxidant status of high-fat fed rats and d-galactose (d-gal)-induced oxidative mice. The anti-hyperlipidemia effects of AO were evaluated. AO supplementation (2%, 4%, and 8%) for three weeks significantly decreased the total cholesterol (TC), triglyceride (TG), and low-density lipoprotein (LDL) levels and increased the high-density lipoprotein (HDL) levels in the high fat diet rats unlike in the model group. The antioxidant activities of AO were determined in the d-gal-injected mice. Results showed that AO (2%, 4%, and 8%) enhanced the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), as well as lowered the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and malondialdehyde (MAD) in the liver of d-gal-injected mice. Compared with olive oil (OO) and rapeseed oil (RSO), the results of tests indicated that AO lowered the hyperlipidemia risk factors by improving plasma antioxidant defenses and lipid profiles.
authors.affiliation: Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education/College of Chemistry and Materials Science, China. licong@nwu.edu.cn nwu-yhshen-lab@vip.163.com and Shaanxi Alcohol Ether and Biomass Energy Engineering Research Center/Key Laboratory of Yulin Desert Plants Resources, Northwest University, Xi'an, 710069, China.
authors.forename: Ya
authors.identifier: http://orcid.org/0000-0001-6668-0625
authors.initials: Y
authors.lastname: Gao
authors.affiliation: Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education/College of Chemistry and Materials Science, China. licong@nwu.edu.cn nwu-yhshen-lab@vip.163.com and Shaanxi Alcohol Ether and Biomass Energy Engineering Research Center/Key Laboratory of Yulin Desert Plants Resources, Northwest University, Xi'an, 710069, China.
authors.forename: Cong
authors.initials: C
authors.lastname: Li
authors.affiliation: Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education/College of Chemistry and Materials Science, China. licong@nwu.edu.cn nwu-yhshen-lab@vip.163.com and Shaanxi Alcohol Ether and Biomass Energy Engineering Research Center/Key Laboratory of Yulin Desert Plants Resources, Northwest University, Xi'an, 710069, China.
authors.forename: Bang
authors.initials: B
authors.lastname: Chen
authors.affiliation: Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education/College of Chemistry and Materials Science, China. licong@nwu.edu.cn nwu-yhshen-lab@vip.163.com and Shaanxi Alcohol Ether and Biomass Energy Engineering Research Center/Key Laboratory of Yulin Desert Plants Resources, Northwest University, Xi'an, 710069, China.
authors.forename: Ye-Hua
authors.initials: YH
authors.lastname: Shen
authors.affiliation: Department of Pharmacology, School of Pharmacy, The Fourth Military Medical University, Xi'an, 710032, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Han
authors.affiliation: Department of Pharmacology, School of Pharmacy, The Fourth Military Medical University, Xi'an, 710032, China.
authors.forename: Ming-Gao
authors.initials: MG
authors.lastname: Zhao
mesh_terms: D000821:Animal Feed; D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D056486:Chemical and Drug Induced Liver Injury / Q000378:metabolism; D004041:Dietary Fats / Q000008:administration & dosage / Q000009:adverse effects; D006949:Hyperlipidemias / Q000139:chemically induced* / Q000188:drug therapy; D000960:Hypolipidemic Agents / Q000737:chemistry / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010938:Plant Oils / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D027824:Rosaceae / Q000737:chemistry*; D012639:Seeds / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D004041:Dietary Fats; D000960:Hypolipidemic Agents; D010938:Plant Oils