title: Isoniazid Induced Lupus Presenting as Oral Mucosal Ulcers with Pancytopenia.
abstract: Drug Induced Lupus Erythematous (DILE) is a rare adverse reaction to a large variety of drugs including Isoniazid (INH), with features resembling idiopathic Systemic Lupus Erythematosus (SLE). Diagnosis require identification of a temporal relationship between drug administered and symptom. It is an idiosyncratic reaction, with no pre-existing lupus. Our case highlights a rare presentation of isoniazid induced lupus with profound pancytopenia and mucosal ulcers, thus posing a diagnostic challenge. The patient was on multidrug treatment for pulmonary and knee joint tuberculosis. DILE was diagnosed on basis of strongly positive Anti Nuclear Antibodies (ANA), anti ds DNA and antihistone antibodies with clinical response to cessation of INH.
authors.affiliation: Resident, Department of Pulmonary Medicine, D.Y. Patil Medical College and Hospital , Mumbai, Maharashtra, India .
authors.forename: Ria
authors.initials: R
authors.lastname: Shah
authors.affiliation: Resident, Department of Pulmonary Medicine, D.Y. Patil Medical College and Hospital , Mumbai, Maharashtra, India .
authors.forename: Padmaraj
authors.initials: P
authors.lastname: Ankale
authors.affiliation: Resident, Department of Pulmonary Medicine, D.Y. Patil Medical College and Hospital , Mumbai, Maharashtra, India .
authors.forename: Kanishk
authors.initials: K
authors.lastname: Sinha
authors.affiliation: Assistant Professor, Department of Pulmonary Medicine, D.Y. Patil Medical College and Hospital , Mumbai, Maharashtra, India .
authors.forename: Aparna
authors.initials: A
authors.lastname: Iyer
authors.affiliation: Professor, Department of Pulmonary Medicine, D.Y. Patil Medical College and Hospital , Mumbai, Maharashtra, India .
authors.forename: T K
authors.initials: TK
authors.lastname: Jayalakshmi
keywords: Anti tubercular treatment; Idiosyncratic reaction; Macrophage activation syndrome; Tuberculosis