title: Neural oscillations in the temporal pole for a temporally congruent audio-visual speech detection task.
abstract: Though recent studies have elucidated the earliest mechanisms of processing in multisensory integration, our understanding of how multisensory integration of more sustained and complicated stimuli is implemented in higher-level association cortices is lacking. In this study, we used magnetoencephalography (MEG) to determine how neural oscillations alter local and global connectivity during multisensory integration processing. We acquired MEG data from 15 healthy volunteers performing an audio-visual speech matching task. We selected regions of interest (ROIs) using whole brain time-frequency analyses (power spectrum density and wavelet transform), then applied phase amplitude coupling (PAC) and imaginary coherence measurements to them. We identified prominent delta band power in the temporal pole (TP), and a remarkable PAC between delta band phase and beta band amplitude. Furthermore, imaginary coherence analysis demonstrated that the temporal pole and well-known multisensory areas (e.g., posterior parietal cortex and post-central areas) are coordinated through delta-phase coherence. Thus, our results suggest that modulation of connectivity within the local network, and of that between the local and global network, is important for audio-visual speech integration. In short, these neural oscillatory mechanisms within and between higher-level association cortices provide new insights into the brain mechanism underlying audio-visual integration.
authors.affiliation: Graduate School of Arts and Sciences, The University of Tokyo, Tokyo, Japan.|Department of Developmental Disorders, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan.
authors.forename: Takefumi
authors.initials: T
authors.lastname: Ohki
authors.affiliation: Department of Developmental Disorders, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan.|College of Educational and Human Science, Yokohama National University, Kanagawa, Japan.|Department of Advanced Neuroimaging, Integrative Brain Imaging Center, National Center of Neurology and Psychiatry, Tokyo, Japan.
authors.forename: Atsuko
authors.initials: A
authors.lastname: Gunji
authors.affiliation: Department of Psychiatry and Neuroscience, Gunma University Graduate School of Medicine, Gunma, Japan.
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Takei
authors.affiliation: Department of Advanced Neuroimaging, Integrative Brain Imaging Center, National Center of Neurology and Psychiatry, Tokyo, Japan.|Department of Child and Adolescent Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan.
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Takahashi
authors.affiliation: Department of Neurosurgery, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan.
authors.forename: Yuu
authors.initials: Y
authors.lastname: Kaneko
authors.affiliation: Department of Developmental Disorders, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan.
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Kita
authors.affiliation: Department of Clinical Neurophysiology, Neurological Institute, Faculty of Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: Naruhito
authors.initials: N
authors.lastname: Hironaga
authors.affiliation: Department of Clinical Neurophysiology, Neurological Institute, Faculty of Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: Shozo
authors.initials: S
authors.lastname: Tobimatsu
authors.affiliation: Department of Child and Adolescent Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Kamio
authors.affiliation: Department of Advanced Neuroimaging, Integrative Brain Imaging Center, National Center of Neurology and Psychiatry, Tokyo, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Hanakawa
authors.affiliation: Department of Developmental Disorders, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan.
authors.forename: Masumi
authors.initials: M
authors.lastname: Inagaki
authors.affiliation: Graduate School of Arts and Sciences, The University of Tokyo, Tokyo, Japan.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Hiraki
mesh_terms: D000328:Adult; D001307:Auditory Perception / Q000502:physiology*; D001931:Brain Mapping; D005260:Female; D006801:Humans; D015225:Magnetoencephalography; D008297:Male; D009415:Nerve Net / Q000502:physiology*; D010775:Photic Stimulation; D013060:Speech / Q000502:physiology*; D013702:Temporal Lobe / Q000502:physiology*; D014796:Visual Perception / Q000502:physiology*