title: [Role of Hippo-YAP/TAZ signaling pathway in mechanotransduction.]
abstract: Transcriptional coactivators YAP(yes associated protein)and TAZ(transcriptional coactivator with PDZ-binding motif)regulate gene expression through binding to transcription factors. Recently, some studies showed that YAP/TAZ activity responded to mechanical inputs such as stiffness of the extracellular matrix and the mechanical regulation of YAP/TAZ controlled cell proliferation or differentiation. Additionally, we revealed important roles of YAP in tissue formation and homeostasis through cellular tension and pressure. These reports indicate that YAP/TAZ are major factors in mechanotransduction connecting between the mechanical environment and cell responses.
authors.affiliation: Department of Developmental and Regenerative Biology, Medical Research Institute.
authors.forename: Erika
authors.initials: E
authors.lastname: Ishihara
authors.affiliation: Department of Developmental and Regenerative Biology, Medical Research Institute.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nishina
mesh_terms: D000818:Animals; D006706:Homeostasis; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism*; D040542:Mechanotransduction, Cellular; D009687:Nuclear Proteins / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D015534:Trans-Activators / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; D009687:Nuclear Proteins; D015534:Trans-Activators; D014157:Transcription Factors; D017346:Protein Serine-Threonine Kinases