title: In vitro Generated Mesenchymal Stem Cells: Suitable Tools to Target Insulin Dependent Diabetes Mellitus?
abstract: A synergy of a pre-accumulated genes with an autoimmunity advancing to slow abolition of pancreatic beta-cells causes insulin deficiency and results enrooting insulin dependent diabetes mellitus (IDDM). As per WHO data worldwide about 150 million people are diabetic and the number may rise to more than double by the year 2025. Any absolute cure for IDDM is not available yet, and one of the credible advent in the field include cell-based therapy. At this conjecture, mesenchymal stem cells (MSC) seems to have a specific and beneficial characteristics due to their in vivo as well as in vitro potential to mimic a pancreatic endocrine phenotype and immune-regulatory actions. MSC have the capacity to tweak endogenous tissue and cells of immune system. They have been proven as secure and efficacious cell-based regenerative therapy, to treat diverse autoimmune, degenerative diseases and tissue injuries. By consolidating characteristics of MSC biology, MSC-based therapy, engineering and advances in the field, MSC have a great potential to bring us notably closer to a much-needed and long-time awaited cure of IDDM. The review discusses MSC-based cellular therapeutic strategies targeting at IDDM. MSC characteristics of immunomodulation and regeneration potential when used alone or in combination with islets or in differentiated form of insulin producing cells (IPC) are taken into consideration for the review purpose.
authors.affiliation: Department of Stem Cells, Transplantation Biology Research And Regenerative Medicine, IKDRC-ITS, Gujarat, India.
authors.forename: Shruti D
authors.initials: SD
authors.lastname: Dave
authors.affiliation: Department of Stem Cells, Transplantation Biology Research And Regenerative Medicine, IKDRC-ITS, Gujarat, India.
authors.forename: Chetan N
authors.initials: CN
authors.lastname: Patel
authors.affiliation: Department of Stem Cells, Transplantation Biology Research And Regenerative Medicine, IKDRC-ITS, Gujarat, India.|Department of Pathology, Laboratory Medicine, Transfusion Services and Immunohematology, IKDRC-ITS, Gujarat, India.
authors.forename: Jignesh V
authors.initials: JV
authors.lastname: Patel
authors.affiliation: Department of Stem Cells, Transplantation Biology Research And Regenerative Medicine, IKDRC-ITS, Gujarat, India.
authors.forename: Umang G
authors.initials: UG
authors.lastname: Thakkar
mesh_terms: D000818:Animals; D018929:Cell Culture Techniques; D002454:Cell Differentiation; D002478:Cells, Cultured; D003922:Diabetes Mellitus, Type 1 / Q000628:therapy*; D006801:Humans; D050417:Insulin-Secreting Cells / Q000502:physiology; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods*; D059630:Mesenchymal Stem Cells / Q000166:cytology* / Q000502:physiology*; D023822:Tissue Engineering / Q000379:methods
keywords: Mesenchymal stem cells; autoimmunity; cell differentiation; diabetes mellitus; insulin producing cells; pancreas