title: Lymphocytic adrenal medullitis and lymphocytic thyroiditis in a laboratory beagle dog.
abstract: Lymphocytic adrenal medullitis characterized by inflammation and atrophy in the medulla of the bilateral adrenal glands was observed in an 18-month-old male laboratory beagle dog. It might be that the present lymphocytic adrenal medullitis is an autoimmune-mediated disease as the histological characteristics are consistent with an autoimmune pathogenesis. However, the actual cause remains unclear as the existence of serum autoantibodies against the adrenal medulla could not be confirmed. Although this dog also contracted lymphocytic thyroiditis along with serum thyroglobulin autoantibodies, indicating that the thyroiditis occurred with an autoimmune basis; the relation between the adrenal medullitis and thyroiditis is unknown.
authors.affiliation: Pathology Department, Kashima Laboratory, Nonclinical Research Center, LSI Medience Corporation, 14-1 Sunayama, Kamisu, Ibaraki 314-0255, Japan.
authors.forename: Takuya
authors.initials: T
authors.lastname: Doi
authors.forename: Yuki
authors.initials: Y
authors.lastname: Tomonari
authors.forename: Kazufumi
authors.initials: K
authors.lastname: Kawasako
authors.forename: Naoaki
authors.initials: N
authors.lastname: Yamada
authors.forename: Minoru
authors.initials: M
authors.lastname: Tsuchitani
mesh_terms: D000307:Adrenal Gland Diseases / Q000276:immunology / Q000662:veterinary*; D000313:Adrenal Medulla / Q000276:immunology / Q000473:pathology*; D000818:Animals; D001323:Autoantibodies / Q000097:blood; D004283:Dog Diseases / Q000276:immunology / Q000473:pathology*; D004285:Dogs; D008214:Lymphocytes / Q000473:pathology; D008297:Male; D013954:Thyroglobulin / Q000097:blood; D013967:Thyroiditis, Autoimmune / Q000276:immunology / Q000473:pathology / Q000662:veterinary*
chemical_list: D001323:Autoantibodies; D013954:Thyroglobulin