title: A1Adenosine Receptor Activation Modulates Central Nervous System Development and Repair.
abstract: Adenosine is an endogenous, autacoid purine nucleoside which performs many important biological roles, particularly during stressful events. Adenosine can signal through four adenosine receptor (AR) subtypes: A1, A2A, A2B, and A3. Of these, adenosine A1receptor (A1AR) has a broad, wide distribution throughout different vertebrate cell types and the highest affinity to adenosine. The A1AR-dependent action of adenosine is well documented in reports from numerous studies that have used different selective A1AR agonists and antagonists as well as in animals that have a genetically manipulated A1AR gene. Despite its wide distribution and function, A1AR homo/hetero-oligomerization with other adenosine and non-adenosine receptors extends its biological role during developmental, physiological, and pathological situations. In this review, we initially discuss the A1AR structure and most important signaling pathway triggered by its activation. Next, we summarize some of the most well-known biological effects of A1AR in the central nervous system (CNS) during development and adulthood, in addition to its role in nervous system regeneration and repair.
authors.affiliation: Department of Cellular Biotechnology, Cell Science Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran.|Department of Developmental Biology, University of Science and Culture, Tehran, Iran.
authors.forename: Shirin
authors.initials: S
authors.lastname: Kashfi
authors.affiliation: Department of Cellular Biotechnology, Cell Science Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran.|Department of Biology, School of Sciences, University of Isfahan, Isfahan, Iran.
authors.forename: Kamran
authors.initials: K
authors.lastname: Ghaedi
authors.affiliation: Department of Developmental Biology, University of Science and Culture, Tehran, Iran.|Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.
authors.forename: Hossein
authors.initials: H
authors.lastname: Baharvand
authors.affiliation: Department of Cellular Biotechnology, Cell Science Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran. mh_nasr@royaninstitute.org.
authors.forename: Mohammad Hossein
authors.initials: MH
authors.lastname: Nasr-Esfahani
authors.affiliation: Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran. mjavan@modares.ac.ir.|Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran. mjavan@modares.ac.ir.
authors.forename: Mohammad
authors.identifier: 0000-0003-2045-6171
authors.initials: M
authors.lastname: Javan
mesh_terms: D000241:Adenosine / Q000494:pharmacology / Q000502:physiology / Q000627:therapeutic use; D058907:Adenosine A1 Receptor Agonists / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D002490:Central Nervous System / Q000187:drug effects / Q000254:growth & development* / Q000378:metabolism*; D002493:Central Nervous System Diseases / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D009416:Nerve Regeneration / Q000187:drug effects / Q000502:physiology; D043682:Receptor, Adenosine A1 / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology
chemical_list: D058907:Adenosine A1 Receptor Agonists; D043682:Receptor, Adenosine A1; D000241:Adenosine
keywords: Adenosine A1 receptor; Multiple sclerosis; Neural development; Neural regeneration and repair; Receptor oligomerization