title: SOCS2 polymorphisms are not associated with clinical and biochemical phenotypes in acromegalic patients.
abstract: OBJECTIVE
  Suppressor of cytokine signaling 2 (SOCS2) is a STAT5b-regulated gene and one of its functions is to influence growth and development through negative regulatory effects on GH/IGF-1 pathway. So, we evaluate the potential influence of SOCS2 single nucleotide polymorphisms (SNPs) on clinical and laboratorial characteristics of a large cohort of Brazilian patients with acromegaly.
  
  
  METHODS
  Four SOCS2 SNPs (rs3782415, rs3816997, rs3825199 and rs11107116) were selected and genotyped by real-time PCR using specific Taqman probe assays. A total of 186 patients (116 women, age range 26-88 years) were evaluated.
  
  
  RESULTS
  No association of SOCS2 genotypes was observed with none of the following clinical and laboratorial characteristics: age, sex, body mass index, comorbidities, basal GH, oral glucose tolerance test GH nadir, IGF-I, ULNR-IGF-I.
  
  
  CONCLUSIONS
  Despite of the key role of SOCS2 in the regulation of GH receptor signaling, we did not find any significant association between SOCS2 polymorphisms and acromegaly.
authors.affiliation: Laboratory of Cellular and Molecular Endocrinology - LIM25, Clinical Hospital of the University of São Paulo Medical School, Av Dr Arnaldo, 455, 4 andar, sala 4345, São Paulo, SP, CEP: 01246-903, Brazil. ericka.trarbach@hc.fm.usp.br.
authors.forename: Ericka B
authors.initials: EB
authors.lastname: Trarbach
authors.affiliation: Laboratory of Cellular and Molecular Endocrinology - LIM25, Clinical Hospital of the University of São Paulo Medical School, Av Dr Arnaldo, 455, 4 andar, sala 4345, São Paulo, SP, CEP: 01246-903, Brazil.
authors.forename: Alexander A
authors.initials: AA
authors.lastname: Jorge
authors.affiliation: Neuroendocrine Unit, Division of Endocrinology and Metabolism, Clinical Hospital of the University of São Paulo Medical School, Av Dr Eneas de Carvalho Aguiar, 155, PAMB, 8 andar, São Paulo, SP, CEP: 05403-010, Brazil.
authors.forename: Felipe H
authors.initials: FH
authors.lastname: Duarte
authors.affiliation: Neuroendocrine Unit, Division of Endocrinology and Metabolism, Clinical Hospital of the University of São Paulo Medical School, Av Dr Eneas de Carvalho Aguiar, 155, PAMB, 8 andar, São Paulo, SP, CEP: 05403-010, Brazil.
authors.forename: Marcello D
authors.initials: MD
authors.lastname: Bronstein
authors.affiliation: Neuroendocrine Unit, Division of Endocrinology and Metabolism, Clinical Hospital of the University of São Paulo Medical School, Av Dr Eneas de Carvalho Aguiar, 155, PAMB, 8 andar, São Paulo, SP, CEP: 05403-010, Brazil.
authors.forename: Raquel S
authors.initials: RS
authors.lastname: Jallad
mesh_terms: D000172:Acromegaly / Q000235:genetics* / Q000473:pathology; D015992:Body Mass Index; D005260:Female; D005838:Genotype; D006801:Humans; D007334:Insulin-Like Growth Factor I; D008297:Male; D010641:Phenotype; D011110:Polymorphism, Genetic / Q000235:genetics*; D015398:Signal Transduction / Q000235:genetics; D050826:Suppressor of Cytokine Signaling Proteins / Q000235:genetics*
chemical_list: C106643:SOCS2 protein, human; D050826:Suppressor of Cytokine Signaling Proteins; D007334:Insulin-Like Growth Factor I
keywords: Acromegaly; Co-morbidities; GH-signaling; SOCS2 polymorphism