title: Uncommon Anal Neoplasms.
abstract: Uncommon neoplasms of the anal canal are associated with significant diagnostic dilemma in clinical practice and a high index of suspicion and pathologic expertise is needed. The incidence is likely to increase, particularly of small, incidental lesions found because of use of more frequent colonoscopy and high-definition MRI. Generally treatment follows that of the same histologic subtype in other anatomic location. Surgical intervention is the cornerstone for cure in early/localized disease; however, removal of the anal canal is associated with significant morbidities and quality of life issues. A centralized global registry/database established under the auspices of the International Rare Care Initiative collaboration would be useful.
authors.affiliation: Department of Medical Oncology, Flinders Centre for Innovation in Cancer, Flinders Medical Centre, Flinders Drive Bedford Park, South Australia, 5042 Australia; Department of Surgery, Flinders University, Sturt Road, Bedford Park, South Australia 5042, Australia.
authors.forename: Amitesh C
authors.initials: AC
authors.lastname: Roy
authors.affiliation: Department of Surgery, Flinders University, Sturt Road, Bedford Park, South Australia 5042, Australia; Department of Surgery, Flinders Medical Centre, Flinders Drive Bedford Park, South Australia, 5042, Australia.
authors.forename: David
authors.initials: D
authors.lastname: Wattchow
authors.affiliation: Department of Surgery, Flinders University, Sturt Road, Bedford Park, South Australia 5042, Australia; Department of Anatomical Pathology, SA Pathology (Flinders Medical Centre), Flinders Drive Bedford Park, South Australia 5042, Australia.
authors.forename: David
authors.initials: D
authors.lastname: Astill
authors.affiliation: Division of Medical Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, 2075 Bayview Ave, Toronto, ON M4N 3M5, Canada Toronto, Ontario, Canada; Department of Medicine, Medical Sciences Building, 1 King's College Cir #3172, University of Toronto, Toronto, ON M5S 1A8, Canada.
authors.forename: Simron
authors.initials: S
authors.lastname: Singh
authors.affiliation: Department of Radiation Oncology, St Vincent's Hospital, Victoria Street, Darlinghurst, Sydney, 2010 New South Wales, Australia.
authors.forename: Susan
authors.initials: S
authors.lastname: Pendlebury
authors.affiliation: Department of Radiology, Dr Jones & Partners Medical Imaging, Tennyson Centre, 520 South Road, Kurralta Park South Australia 5037, Australia.
authors.forename: Kirsten
authors.initials: K
authors.lastname: Gormly
authors.affiliation: Department of Medicine, St Vincent's Clinical School, St Vincent's Hospital, University of New South Wales, Level 5 de Lacy, 438 Victoria Street, Darlinghurst, Sydney, New South Wales 2010, Australia. Electronic address: e.segelov@unsw.edu.au.
authors.forename: Eva
authors.initials: E
authors.lastname: Segelov
mesh_terms: D001005:Anus Neoplasms / Q000473:pathology*; D006801:Humans; D015994:Incidence; D008223:Lymphoma / Q000473:pathology*; D008545:Melanoma / Q000473:pathology*; D018358:Neuroendocrine Tumors / Q000473:pathology*; D011788:Quality of Life
keywords: Anal lymphoma; Anal melanoma; Anal neuroendocrine tumor; Unusual cancers