title: Superacid-Catalyzed Trifluoromethylthiolation of Aromatic Amines.
abstract: Upon activation under superacid conditions, functionalized tailor-made N-SCF3sulfenamides served as reagents for the trifluoromethylthiolation of aromatic amines. This method has a broad substrate scope and can be used for the late-stage functionalization of complex molecules such as alkaloids or steroids. Mechanistic studies based on in situ low-temperature NMR spectroscopy revealed the involvement of dicationic superelectrophilic intermediates.
authors.affiliation: IC2MP-UMR CNRS 7582, Superacid group-Organic Synthesis Team, Université de Poitiers, 4 rue Michel Brunet TSA 51106, 86073, Poitiers cedex 9, France.|PER-AUF-PMTA/PTR-PMTA-CAMES, Unité de Chimie du Végétal et de la Vie, Faculté des Sciences et Techniques, Université Marien-Ngouabi, BP 69-, Brazzaville, Congo.
authors.forename: Longin Justin Clair
authors.initials: LJ
authors.lastname: Bonazaba Milandou
authors.affiliation: IC2MP-UMR CNRS 7582, Superacid group-Organic Synthesis Team, Université de Poitiers, 4 rue Michel Brunet TSA 51106, 86073, Poitiers cedex 9, France.
authors.forename: Hélène
authors.initials: H
authors.lastname: Carreyre
authors.affiliation: Institute of Chemistry and Biochemistry (ICBMS-UMR CNRS 5246), Université Lyon 1, CNRS, 43 Bd du 11 novembre 1918, 69622, Villeurbanne, France.
authors.forename: Sébastien
authors.initials: S
authors.lastname: Alazet
authors.affiliation: IC2MP-UMR CNRS 7582, Superacid group-Organic Synthesis Team, Université de Poitiers, 4 rue Michel Brunet TSA 51106, 86073, Poitiers cedex 9, France.
authors.forename: Gino
authors.initials: G
authors.lastname: Greco
authors.affiliation: IC2MP-UMR CNRS 7582, Superacid group-Organic Synthesis Team, Université de Poitiers, 4 rue Michel Brunet TSA 51106, 86073, Poitiers cedex 9, France.
authors.forename: Agnès
authors.initials: A
authors.lastname: Martin-Mingot
authors.affiliation: PER-AUF-PMTA/PTR-PMTA-CAMES, Unité de Chimie du Végétal et de la Vie, Faculté des Sciences et Techniques, Université Marien-Ngouabi, BP 69-, Brazzaville, Congo.
authors.forename: Célestine
authors.initials: C
authors.lastname: Nkounkou Loumpangou
authors.affiliation: PER-AUF-PMTA/PTR-PMTA-CAMES, Unité de Chimie du Végétal et de la Vie, Faculté des Sciences et Techniques, Université Marien-Ngouabi, BP 69-, Brazzaville, Congo.
authors.forename: Jean-Maurille
authors.initials: JM
authors.lastname: Ouamba
authors.affiliation: @rtMolecule, Bâtiment B37-1, rue Georges Bonnet, 86000, Poitiers, France.
authors.forename: Fodil
authors.initials: F
authors.lastname: Bouazza
authors.affiliation: Institute of Chemistry and Biochemistry (ICBMS-UMR CNRS 5246), Université Lyon 1, CNRS, 43 Bd du 11 novembre 1918, 69622, Villeurbanne, France.
authors.forename: Thierry
authors.initials: T
authors.lastname: Billard
authors.affiliation: IC2MP-UMR CNRS 7582, Superacid group-Organic Synthesis Team, Université de Poitiers, 4 rue Michel Brunet TSA 51106, 86073, Poitiers cedex 9, France.
authors.forename: Sébastien
authors.initials: S
authors.lastname: Thibaudeau
keywords: acidity; amines; fluorine; reaction mechanisms; superacidic systems