title: The association of plasma miR-155 and VCAM-1 levels with coronary collateral circulation.
abstract: OBJECTIVE
  Inflammation plays an important role in development of coronary collateral circulation (CCC). The aim of this study is to determine whether the inflammation-related miRNA miR-155 and the inflammation marker VCAM-1 could be a biomarker for CCC.
  
  
  METHODS
  We measured levels of plasma VCAM-1 and miR-155 in patients with CCC according to Rentrop grade by ELISA or real-time polymerase chain reaction, respectively (n = 112).
  
  
  RESULTS
  Plasma miR-155 was negatively correlated with VCAM-1 in the poor CCC group and with Rentrop grade in all patients with CCC. In addition, plasma VCAM-1 was significantly decreased in CAD patients with CCC.
  
  
  CONCLUSIONS
  Plasma miR-155 might be a potent independent predictor of collateral formation.
authors.affiliation: Department of Cardiology, Second Hospital of Jilin University, No. 218 Ziqiang Street, Changchun 130041, China.
authors.forename: Junnan
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Cardiology, Second Hospital of Jilin University, No. 218 Ziqiang Street, Changchun 130041, China.
authors.forename: Youyou
authors.initials: Y
authors.lastname: Yan
authors.affiliation: Department of Clinical Laboratory, Second Hospital of Jilin University, No. 218 Ziqiang Street, Changchun 130041, China.
authors.forename: Dandan
authors.initials: D
authors.lastname: Song
authors.affiliation: Department of Cardiology, Second Hospital of Jilin University, No. 218 Ziqiang Street, Changchun 130041, China.
authors.forename: Lulu
authors.initials: L
authors.lastname: Liu
authors.affiliation: Department of Cardiology, Second Hospital of Jilin University, No. 218 Ziqiang Street, Changchun 130041, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Liu
mesh_terms: D000368:Aged; D019540:Area Under Curve; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D003097:Collateral Circulation / Q000502:physiology*; D003324:Coronary Artery Disease / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000097:blood* / Q000235:genetics / Q000378:metabolism; D008875:Middle Aged; D012372:ROC Curve; D060888:Real-Time Polymerase Chain Reaction; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood*
chemical_list: D015415:Biomarkers; C524942:MIRN155 microRNA, human; D035683:MicroRNAs; D019010:Vascular Cell Adhesion Molecule-1
keywords: ELISA; Rentrop grade; VCAM-1; biomarker; coronary artery disease; coronary collateral circulation; inflammation; miR-155; miRNA; qRT-PCR