title: Pharmacologic Management of Acute Spinal Cord Injury.
abstract: Spinal cord injury is a serious global public health problem that often leaves patients with devastating permanent disabilities. Although advances in supportive care have improved outcome in recent decades, there remains great need for a safe and efficacious medical treatment that improves neurologic outcome. This article reviews pharmacologic treatments evaluated or in the process of development in humans. Cellular transplantation strategies are briefly reviewed especially where they have been evaluated with pharmacologic treatments. There is great hope that one or more of these new therapeutics will be successfully translated and improve the neurologic recovery of patients in the near future.
authors.affiliation: Department of Neurosurgery, University of Utah, Salt Lake City, UT, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Karsy
authors.affiliation: Department of Neurosurgery, University of Utah, Salt Lake City, UT, USA. Electronic address: gregory.hawryluk@hsc.utah.edu.
authors.forename: Gregory
authors.initials: G
authors.lastname: Hawryluk
mesh_terms: D018450:Disease Progression; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D008775:Methylprednisolone / Q000627:therapeutic use*; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D013119:Spinal Cord Injuries / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D005938:Glucocorticoids; D018696:Neuroprotective Agents; D008775:Methylprednisolone
keywords: Central nervous system; Methylprednisolone; Neuroprotective agent; Neuroregenerative agent; Secondary injury; Spinal cord injury