title: Rhabdomyosarcoma of the Breast in Adolescent and Young Adult (AYA) Women.
abstract: Soft tissue sarcoma constitutes 8% of all tumors in adolescent and young adults (AYA), with rhabdomyosarcoma (RMS) accounting for 5.2% to 6.5% of the soft tissue sarcoma total within this group. AYAs have a higher propensity for metastasis and inferior outcomes. Metastases to the breast have been reported in ∼3% to 6% of RMS cases. A review of our hospital's tumor registry identified cases of RMS diagnosed between January 1, 2004 and December 31, 2013. A total of 46 patients with RMS were identified, having a mean age of 12.5 years (range, 1 to 49 y). There were 26 males (57%) and 20 females (43%). Eighteen patients (39%) were AYAs, including 10 women. Four patients (8.7%) were identified with breast involvement, all of whom were AYA females. Treatment modalities included chemotherapy, surgical resection, and radiation. One patient is a long-term survivor. Although RMS is uncommon in AYAs, breast involvement occurs almost exclusively in AYA women and is associated with alveolar histology, metastatic disease, and poor outcomes. In total, 4/10 of all AYA females had breast involvement. Routine examination or imaging of the breasts in AYAs with RMS is not currently standard practice at diagnosis or follow-up, but this analysis suggests it should be considered in female AYA patients.
authors.affiliation: *Division of Pediatric Hematology/Oncology, Nationwide Children's Hospital †Department of Pediatrics, the Ohio State University, Columbus, OH.
authors.forename: Anthony N
authors.initials: AN
authors.lastname: Audino
authors.forename: Bhuvana A
authors.initials: BA
authors.lastname: Setty
authors.forename: Nicholas D
authors.initials: ND
authors.lastname: Yeager
mesh_terms: D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000032:analysis; D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000556:secondary* / Q000628:therapy; D018567:Breast Neoplasms, Male / Q000453:epidemiology / Q000556:secondary; D003131:Combined Modality Therapy; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008297:Male; D008408:Mastectomy; D012189:Retrospective Studies; D012208:Rhabdomyosarcoma / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000556:secondary* / Q000628:therapy; D016879:Salvage Therapy; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor