title: The real-life effectiveness of psychosocial therapies on social autonomy in schizophrenia patients: Results from a nationwide cohort study in France.
abstract: The objectives of the present study were to describe the prescribing patterns for psychosocial therapies in routine clinical practice and to assess the impact of psychoeducation on symptoms and social autonomy of patients with schizophrenia. We used data from the nationwide French ESPASS observational cohort study including 5967 patients with schizophrenia, which provided data on exposure to psychosocial therapies from 4961 (83%) participants. Patients who initiated psychosocial therapy within the first 3 months of study onset (n=143) were compared to patients not subject to psychosocial therapy throughout follow up (n=4268), using parametric tests. Symptom severity and social autonomy at 6 months from baseline were compared between patients undergoing psychoeducation (n=117) and patients not subject to psychosocial therapy, matched (1:1) on propensity scores. Patients who initiated psychosocial therapy were significantly younger, more severely ill and used less often antipsychotic drugs than patients in the reference group. At 6 months, patients who initiated psychoeducation and their matched referents did not differ significantly in terms of symptom severity, but their level of improvement in social autonomy was significantly greater (p=0.005). In routine clinical practice, psychoeducation in addition to antipsychotic drugs provides some benefit among schizophrenia patients, particularly in terms of social autonomy.
authors.affiliation: CESP, Paris-Sud University, Paris-Saclay University, INSERM, 16 avenue Paul Vaillant-Couturier, 94805 Villejuif, France.
authors.forename: Aminata
authors.initials: A
authors.lastname: Ali
authors.affiliation: CESP, Paris-Sud University, Paris-Saclay University, INSERM, 16 avenue Paul Vaillant-Couturier, 94805 Villejuif, France; Savoie Mont Blanc University, LIPP C2S EA 4145, Domaine Universitaire de Jacob, BP1104, 73000 Chambéry, France.
authors.forename: Arnaud
authors.initials: A
authors.lastname: Carre
authors.affiliation: CESP, Paris-Sud University, Paris-Saclay University, INSERM, 16 avenue Paul Vaillant-Couturier, 94805 Villejuif, France.
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Orri
authors.affiliation: Centre Expert Schizophrénie, Versailles Hospital Centre,177 rue de Versailles, 78157 Le Chesnay cedex, France.
authors.forename: Mathieu
authors.initials: M
authors.lastname: Urbach
authors.affiliation: CESP, Paris-Sud University, Paris-Saclay University, INSERM, 16 avenue Paul Vaillant-Couturier, 94805 Villejuif, France.
authors.forename: Caroline
authors.initials: C
authors.lastname: Barry
authors.affiliation: CESP, Paris-Sud University, Paris-Saclay University, INSERM, 16 avenue Paul Vaillant-Couturier, 94805 Villejuif, France.
authors.forename: Christine
authors.initials: C
authors.lastname: Hassler
authors.affiliation: CESP, Paris-Sud University, Paris-Saclay University, INSERM, 16 avenue Paul Vaillant-Couturier, 94805 Villejuif, France.
authors.forename: Bruno
authors.initials: B
authors.lastname: Falissard
authors.affiliation: Institute for Cognitive and Integrative Neuroscience, 146 rue Léo Saignat, 33000 Bordeaux, France.
authors.forename: Sylvie
authors.initials: S
authors.lastname: Berthoz
authors.affiliation: CESP, Paris-Sud University, Paris-Saclay University, INSERM, 16 avenue Paul Vaillant-Couturier, 94805 Villejuif, France; LASER Analytica, 10 place de Catalogne, 75014 Paris, France. Electronic address: clementine.nordon@la-ser.com.
authors.forename: Clementine
authors.initials: C
authors.lastname: Nordon
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use; D015331:Cohort Studies; D005260:Female; D005602:France; D006801:Humans; D008297:Male; D026684:Personal Autonomy; D057216:Propensity Score; D011613:Psychotherapy / Q000379:methods*; D012559:Schizophrenia / Q000628:therapy*; D012565:Schizophrenic Psychology; D012919:Social Behavior; D016896:Treatment Outcome
chemical_list: D014150:Antipsychotic Agents
keywords: Clinical effectiveness; Psychoeducation; Psychotherapy