title: LncRNAs: the bridge linking RNA and colorectal cancer.
abstract: Long noncoding RNAs (lncRNAs) are transcribed by genomic regions (exceeding 200 nucleotides in length) that do not encode proteins. While the exquisite regulation of lncRNA transcription can provide signals of malignant transformation, lncRNAs control pleiotropic cancer phenotypes through interactions with other cellular molecules including DNA, protein, and RNA. Recent studies have demonstrated that dysregulation of lncRNAs is influential in proliferation, angiogenesis, metastasis, invasion, apoptosis, stemness, and genome instability in colorectal cancer (CRC), with consequent clinical implications. In this review, we explicate the roles of different lncRNAs in CRC, and the potential implications for their clinical application.
authors.affiliation: Department of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, West China Second Hospital and State Key Laboratory of Biotherapy/Collaborative Innovation Center, West China Hospital, Sichuan University, Chengdu, P. R. China.
authors.forename: Yanfei
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, West China Second Hospital and State Key Laboratory of Biotherapy/Collaborative Innovation Center, West China Hospital, Sichuan University, Chengdu, P. R. China.
authors.forename: Linjie
authors.initials: L
authors.lastname: Zhao
authors.affiliation: Department of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, West China Second Hospital and State Key Laboratory of Biotherapy/Collaborative Innovation Center, West China Hospital, Sichuan University, Chengdu, P. R. China.
authors.forename: Lingzi
authors.initials: L
authors.lastname: Lei
authors.affiliation: Department of Emergency Medicine, Thomas Jefferson University Hospital, U.S.A.
authors.forename: Wayne Bond
authors.initials: WB
authors.lastname: Lau
authors.affiliation: Department of Emergency Medicine, Kaiser Permanente Santa Clara Medical Center, Affiliate of Stanford University, U.S.A.
authors.forename: Bonnie
authors.initials: B
authors.lastname: Lau
authors.affiliation: Department of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, West China Second Hospital and State Key Laboratory of Biotherapy/Collaborative Innovation Center, West China Hospital, Sichuan University, Chengdu, P. R. China.
authors.forename: Qilian
authors.initials: Q
authors.lastname: Yang
authors.affiliation: Department of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, West China Second Hospital and State Key Laboratory of Biotherapy/Collaborative Innovation Center, West China Hospital, Sichuan University, Chengdu, P. R. China.
authors.forename: Xiaobing
authors.initials: X
authors.lastname: Le
authors.affiliation: Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, P. R. China.
authors.forename: Huiliang
authors.initials: H
authors.lastname: Yang
authors.affiliation: College of Life Sciences, Sichuan University, Chengdu, P. R. China.
authors.forename: Chenlu
authors.initials: C
authors.lastname: Wang
authors.affiliation: College of Life Sciences, Sichuan University, Chengdu, P. R. China.
authors.forename: Zhongyue
authors.initials: Z
authors.lastname: Luo
authors.affiliation: Department of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, West China Second Hospital and State Key Laboratory of Biotherapy/Collaborative Innovation Center, West China Hospital, Sichuan University, Chengdu, P. R. China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Xuan
authors.affiliation: Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, P.R. China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, P.R. China.
authors.forename: Xiangbing
authors.initials: X
authors.lastname: Deng
authors.affiliation: Department of Pathology, West China Second Hospital, Sichuan University, Chengdu, P. R. China.
authors.forename: Lian
authors.initials: L
authors.lastname: Xu
authors.affiliation: Department of Pathology, West China Second Hospital, Sichuan University, Chengdu, P. R. China.
authors.forename: Min
authors.initials: M
authors.lastname: Feng
authors.affiliation: Department of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, West China Second Hospital and State Key Laboratory of Biotherapy/Collaborative Innovation Center, West China Hospital, Sichuan University, Chengdu, P. R. China.
authors.forename: Tao
authors.initials: T
authors.lastname: Yi
authors.affiliation: Department of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, West China Second Hospital and State Key Laboratory of Biotherapy/Collaborative Innovation Center, West China Hospital, Sichuan University, Chengdu, P. R. China.
authors.forename: Xia
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Department of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, West China Second Hospital and State Key Laboratory of Biotherapy/Collaborative Innovation Center, West China Hospital, Sichuan University, Chengdu, P. R. China.
authors.forename: Yuquan
authors.initials: Y
authors.lastname: Wei
authors.affiliation: Department of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, West China Second Hospital and State Key Laboratory of Biotherapy/Collaborative Innovation Center, West China Hospital, Sichuan University, Chengdu, P. R. China.
authors.forename: Shengtao
authors.initials: S
authors.lastname: Zhou
mesh_terms: D017209:Apoptosis / Q000235:genetics; D049109:Cell Proliferation / Q000235:genetics; D015179:Colorectal Neoplasms / Q000098:blood supply / Q000235:genetics* / Q000473:pathology; D015972:Gene Expression Regulation, Neoplastic; D042822:Genomic Instability / Q000235:genetics; D006801:Humans; D008957:Models, Genetic; D009389:Neovascularization, Pathologic / Q000235:genetics; D062085:RNA, Long Noncoding / Q000235:genetics*; D015398:Signal Transduction / Q000235:genetics*
chemical_list: D062085:RNA, Long Noncoding
keywords: angiogenesis; colorectal cancer; lncRNAs; metastasis; proliferation