title: Accumulation and Determination of Phenylethanolamine A Residue in Hair of Swine and Sheep.
abstract: The present study proposed the use of liquid chromatography-tandem mass spectrometry to detect the novel β-agonist phenylethanolamine A (PEA) in incurred hair samples of swine and sheep and to assess its accumulation for residue monitoring. The method showed good percent recoveries ranging from 93.2% to 102% and good coefficient of variation at <15%. The experiment was conducted in swine (24 treated and 4 controls) and sheep (3 treated and 1 control). PEA concentration was determined in hair during the treatment. High residue concentrations were present in hair as early as Day 24 (14.8 ± 3.6 and 25.8 ± 7.6 ng/g) and Day 21 (23.4 ± 6.6 ng/g) for swine and sheep; these residues persisted until withdrawal on Days 14 and 21. Results showed high PEA accumulation in hair, thereby indicating the use of hair as a matrix in the control of PEA abuse in farm animals.
authors.affiliation: Institute of Quality Standards and Testing Technology for Agricultural Products, Chinese Academy of Agricultural Science, No. 12 South Street, Zhongguancun, Beijing 100081, China.
authors.forename: Suo
authors.initials: S
authors.lastname: Decheng
authors.affiliation: Institute of Quality Standards and Testing Technology for Agricultural Products, Chinese Academy of Agricultural Science, No. 12 South Street, Zhongguancun, Beijing 100081, China.
authors.forename: Wang
authors.initials: W
authors.lastname: Ruiguo
authors.affiliation: Institute of Quality Standards and Testing Technology for Agricultural Products, Chinese Academy of Agricultural Science, No. 12 South Street, Zhongguancun, Beijing 100081, China.
authors.forename: Wang
authors.initials: W
authors.lastname: Peilong
authors.affiliation: Institute of Quality Standards and Testing Technology for Agricultural Products, Chinese Academy of Agricultural Science, No. 12 South Street, Zhongguancun, Beijing 100081, China.
authors.forename: Zhao
authors.initials: Z
authors.lastname: Genlong
authors.affiliation: Institute of Quality Standards and Testing Technology for Agricultural Products, Chinese Academy of Agricultural Science, No. 12 South Street, Zhongguancun, Beijing 100081, China.
authors.forename: Fan
authors.initials: F
authors.lastname: Yufei
authors.affiliation: Institute of Quality Standards and Testing Technology for Agricultural Products, Chinese Academy of Agricultural Science, No. 12 South Street, Zhongguancun, Beijing 100081, China.
authors.forename: Fan
authors.initials: F
authors.lastname: Xia
authors.affiliation: Institute of Quality Standards and Testing Technology for Agricultural Products, Chinese Academy of Agricultural Science, No. 12 South Street, Zhongguancun, Beijing 100081, China.
authors.forename: Li
authors.initials: L
authors.lastname: Yang
authors.affiliation: Institute of Quality Standards and Testing Technology for Agricultural Products, Chinese Academy of Agricultural Science, No. 12 South Street, Zhongguancun, Beijing 100081, China.
authors.forename: Su
authors.initials: S
authors.lastname: Xiaoou
mesh_terms: D015078:2-Hydroxyphenethylamine / Q000031:analogs & derivatives* / Q000032:analysis; D000318:Adrenergic beta-Agonists / Q000032:analysis*; D000818:Animals; D002853:Chromatography, Liquid; D004350:Drug Residues / Q000032:analysis*; D005260:Female; D006197:Hair / Q000737:chemistry*; D008297:Male; D012756:Sheep; D015813:Substance Abuse Detection / Q000295:instrumentation / Q000379:methods* / Q000662:veterinary*; D013552:Swine; D053719:Tandem Mass Spectrometry
chemical_list: C000608765:2-(4-(nitrophenyl)butan-2-ylamino)-1-(4-methoxyphenyl)ethanol; D000318:Adrenergic beta-Agonists; D015078:2-Hydroxyphenethylamine