title: Palladium-mediated in situ synthesis of an anticancer agent.
abstract: As a novel prodrug activation strategy Pd(0) nanoparticles, entrapped within a modular polymeric support, were used in cell culture, to synthesise the anticancer agent PP-121 from two non-toxic precursors, thereby inducing cell death in the first example of in situ mediated drug synthesis.
authors.affiliation: EaStCHEM School of Chemistry, University of Edinburgh, David Brewster Road, EH9 3FJ Edinburgh, UK. Mark.Bradley@ed.ac.uk.
authors.forename: Eugenio
authors.initials: E
authors.lastname: Indrigo
authors.affiliation: EaStCHEM School of Chemistry, University of Edinburgh, David Brewster Road, EH9 3FJ Edinburgh, UK. Mark.Bradley@ed.ac.uk.
authors.forename: Jessica
authors.initials: J
authors.lastname: Clavadetscher
authors.affiliation: EaStCHEM School of Chemistry, University of Edinburgh, David Brewster Road, EH9 3FJ Edinburgh, UK. Mark.Bradley@ed.ac.uk.
authors.forename: Sunay V
authors.initials: SV
authors.lastname: Chankeshwara
authors.affiliation: EaStCHEM School of Chemistry, University of Edinburgh, David Brewster Road, EH9 3FJ Edinburgh, UK. Mark.Bradley@ed.ac.uk.
authors.forename: Annamaria
authors.initials: A
authors.lastname: Lilienkampf
authors.affiliation: EaStCHEM School of Chemistry, University of Edinburgh, David Brewster Road, EH9 3FJ Edinburgh, UK. Mark.Bradley@ed.ac.uk.
authors.forename: Mark
authors.initials: M
authors.lastname: Bradley
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D010316:Particle Size; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013499:Surface Properties; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; C533409:PP121 compound; D011720:Pyrazoles; D011743:Pyrimidines; D010165:Palladium