title: The Spatio-Temporal Expression Profiles of CD4 + T Cell Differentiation and Function-Related Genes During EAE Pathogenesis.
abstract: Multiple sclerosis is a CD4+T cell-mediated autoimmune disease of the central nervous system. The unbalance of the cytokines and transcription factors critical for CD4+T cell differentiation and function is probably the main reason that causes MS. We detected the mRNA expression changes of key cytokines and transcription factors which are critical for Th1, Th2, Th17, and Treg cell differentiation and function in different tissues during EAE pathogenesis. We fund that each gene not only has its own featured expression changes, but also has interaction with one another, which composes a network of immunity. Understanding the roles of key cytokines and transcription factors in these processes will help to understand disease pathogenesis and supply indications for disease therapy.
authors.affiliation: Research Center for Translational Medicine at East Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, 1239 Si Ping Road, Shanghai, 200092, China.
authors.forename: Yingying
authors.initials: Y
authors.lastname: Cai
authors.affiliation: Tongji Hospital of Tongji University Branch, Tongji University, 1239 Si Ping Road, Shanghai, 200092, China.
authors.forename: Hu
authors.initials: H
authors.lastname: Shen
authors.affiliation: Research Center for Translational Medicine at East Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, 1239 Si Ping Road, Shanghai, 200092, China.
authors.forename: Chaoyan
authors.initials: C
authors.lastname: Qin
authors.affiliation: Research Center for Translational Medicine at East Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, 1239 Si Ping Road, Shanghai, 200092, China.
authors.forename: Jinfeng
authors.initials: J
authors.lastname: Zhou
authors.affiliation: Research Center for Translational Medicine at East Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, 1239 Si Ping Road, Shanghai, 200092, China.
authors.forename: Weiming
authors.initials: W
authors.lastname: Lai
authors.affiliation: Tongji Hospital of Tongji University Branch, Tongji University, 1239 Si Ping Road, Shanghai, 200092, China. 90782@tongji.edu.cn.
authors.forename: Juping
authors.initials: J
authors.lastname: Pan
authors.affiliation: Research Center for Translational Medicine at East Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, 1239 Si Ping Road, Shanghai, 200092, China. ducs2015@163.com.|State key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. ducs2015@163.com.
authors.forename: Changsheng
authors.initials: C
authors.lastname: Du
mesh_terms: D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology / Q000378:metabolism*; D002454:Cell Differentiation / Q000235:genetics* / Q000276:immunology; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000209:etiology* / Q000473:pathology; D053263:Gene Regulatory Networks / Q000276:immunology*; D006801:Humans; D051379:Mice; D009103:Multiple Sclerosis / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000166:cytology; D050378:T-Lymphocytes, Regulatory / Q000166:cytology; D014157:Transcription Factors / Q000276:immunology; D059467:Transcriptome
chemical_list: D014157:Transcription Factors
keywords: cytokine; experimental autoimmune encephalomyelitis; multiple sclerosis; transcription factor