title: Smartphone-based portable wireless optical system for the detection of target analytes.
abstract: Rapid and accurate on-site wireless measurement of hazardous molecules or biomarkers is one of the biggest challenges in nanobiotechnology. A novel smartphone-based Portable and Wireless Optical System (PAWS) for rapid, quantitative, and on-site analysis of target analytes is described. As a proof-of-concept, we employed gold nanoparticles (GNP) and an enzyme, horse radish peroxidase (HRP), to generate colorimetric signals in response to two model target molecules, melamine and hydrogen peroxide, respectively. The colorimetric signal produced by the presence of the target molecules is converted to an electrical signal by the inbuilt electronic circuit of the device. The converted electrical signal is then measured wirelessly via multimeter in the smartphone which processes the data and displays the results, including the concentration of analytes and its significance. This handheld device has great potential as a programmable and miniaturized platform to achieve rapid and on-site detection of various analytes in a point-of-care testing (POCT) manner.
authors.affiliation: Department of Chemical and Biomolecular Engineering (BK 21+ program), Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea.
authors.forename: Shreedhar
authors.initials: S
authors.lastname: Gautam
authors.affiliation: Department of Chemical and Biomolecular Engineering (BK 21+ program), Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea.
authors.forename: Bhagwan S
authors.initials: BS
authors.lastname: Batule
authors.affiliation: Department of Chemical and Biomolecular Engineering (BK 21+ program), Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea.
authors.forename: Hyo Yong
authors.initials: HY
authors.lastname: Kim
authors.affiliation: Department of Chemical and Biomolecular Engineering (BK 21+ program), Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea.
authors.forename: Ki Soo
authors.initials: KS
authors.lastname: Park
authors.affiliation: Department of Chemical and Biomolecular Engineering (BK 21+ program), Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea.
authors.forename: Hyun Gyu
authors.initials: HG
authors.lastname: Park
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation*; D003124:Colorimetry / Q000295:instrumentation*; D006861:Hydrogen Peroxide / Q000378:metabolism; D000068997:Smartphone; D014227:Triazines / Q000032:analysis
chemical_list: D014227:Triazines; D006861:Hydrogen Peroxide; C011907:melamine
keywords: Biosensor; Colorimetric detection; Hydrogen peroxide; Melamine; Multimeter