title: Zabofloxacin for chronic bronchitis.
abstract: Treatment of lower respiratory tract infection poses as an ongoing challenge among respiratory tract diseases. Bacterial infections are causes of acute exacerbations in chronic bronchitis and indications for antibacterial therapy. Several antibiotics were applied to treat bacterial infections in chronic bronchitis, among them fluoroquinolones are considered potent, broad-spectrum agents with excellent tissue penetration. This monograph focuses on zabofloxacin, a novel fluoroquinolone agent recently approved and launched in South Korea, and summarizes the drug's antibacterial efficacy, pharmacokinetic properties and toxicity. Recent advances concerning fluoroquinolones in chronic bronchitis will be discussed, along with a comparison between zabofloxacin and moxifloxacin. Zabofloxacin has proved to be noninferior to moxifloxacin against major community-acquired Gram-positive and Gram-negative respiratory tract pathogens and found to be well tolerated in both oral and parenteral administrations. These features can make it a potential antimicrobial agent in therapy of chronic bronchitis and other lower respiratory tract infections.
authors.affiliation: Institute of Medical Microbiology, Semmelweis University, Budapest, Hungary. kocsis.bela@med.semmelweis-univ.hu.
authors.forename: B
authors.initials: B
authors.lastname: Kocsis
authors.affiliation: Institute of Medical Microbiology, Semmelweis University, Budapest, Hungary.
authors.forename: D
authors.initials: D
authors.lastname: Szabo
mesh_terms: D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D029481:Bronchitis, Chronic / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D000068456:Clinical Studies as Topic; D004333:Drug Administration Routes; D004353:Drug Evaluation, Preclinical; D024841:Fluoroquinolones / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D006801:Humans; D000077266:Moxifloxacin; D012141:Respiratory Tract Infections / Q000188:drug therapy / Q000382:microbiology; D016896:Treatment Outcome
chemical_list: D000890:Anti-Infective Agents; D024841:Fluoroquinolones; C480202:zabofloxacin; D000077266:Moxifloxacin
keywords: DW-224a; DW-224aa; Fluoroquinolones; Respiratory tract infection; Zabofloxacin