title: Cutaneous Human Papillomavirus Infection and Development of Subsequent Squamous Cell Carcinoma of the Skin.
abstract: The role of cutaneous human papillomavirus (HPV) infection in the development of subsequent cutaneous squamous cell carcinoma (SCC) is unknown. Pathologically confirmed cases of SCC (n= 150) enrolled in a previously conducted case-control study were included in a retrospective cohort study to examine the association of cutaneous HPV at the time of SCC diagnosis with the risk of subsequent SCC development. Data on HPV seropositivity, HPV DNA in eyebrow hairs (EB) and SCC tumors were available from the parent study. Incidence of subsequent SCC was estimated using person-years of follow up. Cox Proportional Hazards ratios were estimated to evaluate the associations of both, HPV seropositivity and HPV DNA positivity with subsequent SCC. The five year cumulative incidence of subsequent SCC was 72%. Seropositivity to cutaneous HPV was not associated with the risk of subsequent SCC (HR = 0.83, 95% CI = 0.41-1.67). Any beta HPV infection in EB was associated with reduced risk (HR = 0.30, 95% CI = 0.11-0.78) of subsequent SCC among cases who were positive for beta HPV DNA in tumor tissue. Infection with beta HPV type 2 (HR = 0.32, 95% CI = 0.12-0.86) in EB was associated with reduced risk of subsequent SCC among HPV DNA positive SCCs. In conclusion, beta HPV infection was inversely associated with the risk of subsequent SCC.
authors.affiliation: Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, USA.
authors.forename: Shalaka S
authors.identifier: 0000-0001-8876-2082
authors.initials: SS
authors.lastname: Hampras
authors.affiliation: Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, USA.
authors.forename: Rhianna A
authors.initials: RA
authors.lastname: Reed
authors.affiliation: University of South Florida, Morsani College of Medicine, Tampa, Florida, USA.
authors.forename: Spencer
authors.initials: S
authors.lastname: Bezalel
authors.affiliation: University of South Florida, Morsani College of Medicine, Tampa, Florida, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Cameron
authors.affiliation: Department of Dermatology, University of South Florida, College of Medicine, Tampa, FL, USA; Department of Cutaneous Surgery, University of South Florida, College of Medicine, Tampa, FL, USA.
authors.forename: Basil
authors.initials: B
authors.lastname: Cherpelis
authors.affiliation: Department of Dermatology, University of South Florida, College of Medicine, Tampa, FL, USA; Department of Cutaneous Surgery, University of South Florida, College of Medicine, Tampa, FL, USA.
authors.forename: Neil
authors.initials: N
authors.lastname: Fenske
authors.affiliation: Cutaneous Oncology Program, Moffitt Cancer Center, Tampa, Florida, USA.
authors.forename: Vernon K
authors.initials: VK
authors.lastname: Sondak
authors.affiliation: Department of Dermatology, University of South Florida, College of Medicine, Tampa, FL, USA; Cutaneous Oncology Program, Moffitt Cancer Center, Tampa, Florida, USA; Departments of Pathology and Cell Biology, University of South Florida, College of Medicine, Tampa, FL, USA.
authors.forename: Jane
authors.initials: J
authors.lastname: Messina
authors.affiliation: Infections and Cancer Biology Group, International Agency for Research on Cancer-World Health Organization, Lyon 69372, France.
authors.forename: Massimo
authors.initials: M
authors.lastname: Tommasino
authors.affiliation: Infections and Cancer Biology Group, International Agency for Research on Cancer-World Health Organization, Lyon 69372, France.
authors.forename: Tarik
authors.initials: T
authors.lastname: Gheit
authors.affiliation: Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, USA.
authors.forename: Dana E
authors.initials: DE
authors.lastname: Rollison