title: Comparison of MRI, CT and 18F-FDG PET/CT in the diagnosis of local and metastatic of nasopharyngeal carcinomas: an updated meta analysis of clinical studies.
abstract: BACKGROUND
  A meta-analysis was conducted to evaluate the accuracy of MRI, CT and FDG PET/CT in TNM stage of nasopharyngeal carcinoma patients (NPC).
  
  
  METHODS
  Through a search of studies from 1996 to April 2015, pooled estimated sensitivity, specificity, pooled diagnostic odds ratio (DOR), summary receiver operating characteristic (SROC) curves and Q*-index were calculated.
  
  
  RESULTS
  Totally 23 studies were included for analysis. In T stage, the pooled sensitivity, specificity, DOR and SROC of MRI were 0.95 (95% CI 0.93-0.97), 0.76 (95% CI 0.71-0.80), 86.85 (16.36-461.06) and 0.9213 (SE 0.0372) respectively. The pooled sensitivity, specificity, DOR and SROC of CT were 0.84 (95% CI 0.79 to 0.88), 0.80 (95% CI 0.71 to 0.88), 6.32 (1.17 to 34.02) and 0.7215 (SE 0.054) respectively. The pooled sensitivity, specificity, DOR and SROC of FDG PET/CT were 0.85 (95% CI 0.76 to 0.91), 0.91 (95% CI 0.84 to 0.96) and 0.8673 (SE 0.0311). In N stage, the pooled sensitivity, specificity, DOR and SROC of MRI were 0.88 (95% CI 0.85-0.90), 0.95 (95% CI 0.93-0.97), 93.68 (23.21-379.69) and 0.9153 (SE 0.099) respectively. The pooled sensitivity, specificity, DOR and SROC of CT were 0.92 (95% CI 0.88-0.95), 0.93 (0.76-0.99), 93.81 (22.39-393.03) and 0.8872 (SE 0.0520) respectively. The pooled sensitivity, specificity, DOR and SROC of FDG PET/CT were 0.88 (95% CI 0.85-0.90), 0.95 (95% CI 0.93-0.97), 93.88 (23.21-379.69) and 0.9153 (SE 0.0299) respectively. In M stage, the pooled sensitivity and specificity of MRI were 0.53 (95% CI 0.35-0.70) and 0.99 (95% 0.95-1.00). The pooled sensitivity and specificity of CT were 0.80 (95% CI 0.44-0.97) and 0.93 (95% CI 0.86-0.97) respectively. The pooled sensitivity, specificity and SROC of FDG PET/CT were 0.82 (95% 0.74-0.88), 0.98 (95% CI 0.96-0.99) and 0.9002 (SE 0.075) respectively.
  
  
  CONCLUSIONS
  The analysis suggested that MRI had good accuracy in diagnosis of T stage. Whereas CT is currently a good performance in diagnosis of N stage, FDG PET/CT shows good accuracy in diagnosis of M stage.
authors.affiliation: Department of Radiology, People's Hospital of Hainan Province Haikou 570311, China.
authors.forename: Wang-Sheng
authors.initials: WS
authors.lastname: Chen
authors.affiliation: Department of Radiology, People's Hospital of Hainan Province Haikou 570311, China.
authors.forename: Jian-Jun
authors.initials: JJ
authors.lastname: Li
authors.affiliation: Department of Gynacology, People's Hospital of Hainan Province Haikou 570311, China.
authors.forename: Lan
authors.initials: L
authors.lastname: Hong
authors.affiliation: Department of Radiology, People's Hospital of Hainan Province Haikou 570311, China.
authors.forename: Zeng-Bao
authors.initials: ZB
authors.lastname: Xing
authors.affiliation: Department of Radiotherapy, People's Hospital of Hainan Province Haikou 570311, China.
authors.forename: Fen
authors.initials: F
authors.lastname: Wang
authors.affiliation: Department of Radiology, People's Hospital of Hainan Province Haikou 570311, China.
authors.forename: Chang-Qing
authors.initials: CQ
authors.lastname: Li
keywords: CT; FDG PET/CT; MRI; Meta-analysis; nasopharyngeal carcinoma