title: Glutamatergic synaptic integration of locomotion speed via septoentorhinal projections.
abstract: The medial septum and diagonal band of Broca (MSDB) send glutamatergic axons to medial entorhinal cortex (MEC). We found that this pathway provides speed-correlated input to several MEC cell-types in layer 2/3. The speed signal is integrated most effectively by pyramidal cells but also excites stellate cells and interneurons. Thus, the MSDB conveys speed information that can be used by MEC neurons for spatial representation of self-location.
authors.affiliation: Neuronal Networks Group, German Center for Neurodegenerative Diseases, Bonn, Germany.
authors.forename: Daniel
authors.initials: D
authors.lastname: Justus
authors.affiliation: Neuronal Networks Group, German Center for Neurodegenerative Diseases, Bonn, Germany.
authors.forename: Dennis
authors.initials: D
authors.lastname: Dalügge
authors.affiliation: Neuronal Networks Group, German Center for Neurodegenerative Diseases, Bonn, Germany.
authors.forename: Stefanie
authors.initials: S
authors.lastname: Bothe
authors.affiliation: Neuronal Networks Group, German Center for Neurodegenerative Diseases, Bonn, Germany.
authors.forename: Falko
authors.initials: F
authors.lastname: Fuhrmann
authors.affiliation: Neuronal Networks Group, German Center for Neurodegenerative Diseases, Bonn, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Hannes
authors.affiliation: Neuronal Networks Group, German Center for Neurodegenerative Diseases, Bonn, Germany.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kaneko
authors.affiliation: Neuronal Networks Group, German Center for Neurodegenerative Diseases, Bonn, Germany.
authors.forename: Detlef
authors.initials: D
authors.lastname: Friedrichs
authors.affiliation: Neuronal Networks Group, German Center for Neurodegenerative Diseases, Bonn, Germany.
authors.forename: Liudmila
authors.initials: L
authors.lastname: Sosulina
authors.affiliation: Functional Neuroconnectomics Group, Department of Epileptology, University of Bonn Medical Center, Bonn, Germany.
authors.forename: Inna
authors.initials: I
authors.lastname: Schwarz
authors.affiliation: Axon Growth and Regeneration Group, German Center for Neurodegenerative Diseases, Bonn, Germany.
authors.forename: David Anthony
authors.initials: DA
authors.lastname: Elliott
authors.affiliation: Department of Epileptology, University of Bonn Medical Center, Bonn, Germany.|Department of Neuropathology, University of Bonn Medical Center, Bonn, Germany.
authors.forename: Susanne
authors.initials: S
authors.lastname: Schoch
authors.affiliation: Axon Growth and Regeneration Group, German Center for Neurodegenerative Diseases, Bonn, Germany.
authors.forename: Frank
authors.initials: F
authors.lastname: Bradke
authors.affiliation: Functional Neuroconnectomics Group, Department of Epileptology, University of Bonn Medical Center, Bonn, Germany.
authors.forename: Martin Karl
authors.initials: MK
authors.lastname: Schwarz
authors.affiliation: Neuronal Networks Group, German Center for Neurodegenerative Diseases, Bonn, Germany.|Department of Epileptology, University of Bonn Medical Center, Bonn, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Remy
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology; D018728:Entorhinal Cortex / Q000502:physiology*; D006624:Hippocampus / Q000502:physiology*; D007395:Interneurons / Q000378:metabolism; D008124:Locomotion / Q000502:physiology*; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D009415:Nerve Net / Q000502:physiology; D009474:Neurons / Q000502:physiology*; D017966:Pyramidal Cells / Q000378:metabolism; D009435:Synaptic Transmission / Q000502:physiology*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
chemical_list: D005680:gamma-Aminobutyric Acid