title: Dearomatisation approaches to spirocyclic dienones via the electrophilic activation of alkynes.
abstract: Two complementary dearomatising spirocyclisation protocols to generate spirocyclic dienones from anisole and phenol-tethered ynones are described, each proceeding via electrophilic alkyne activation. The first approach focuses on the spirocyclisation of para-substituted anisoles using either SnCl2·2H2O or Cu(OTf)2. The second approach, which enables the spirocyclisation of both ortho- and para-substituted phenols, uses silica-supported AgNO3to generate similar scaffolds with much greater efficiency. Initial asymmetric studies are also outlined.
authors.affiliation: University of York, Heslington, York YO10 5DD, UK. richard.taylor@york.ac.uk william.unsworth@york.ac.uk.
authors.forename: Aimee K
authors.initials: AK
authors.lastname: Clarke
authors.affiliation: University of York, Heslington, York YO10 5DD, UK. richard.taylor@york.ac.uk william.unsworth@york.ac.uk.
authors.forename: John T R
authors.initials: JT
authors.lastname: Liddon
authors.affiliation: University of York, Heslington, York YO10 5DD, UK. richard.taylor@york.ac.uk william.unsworth@york.ac.uk.
authors.forename: James D
authors.initials: JD
authors.lastname: Cuthbertson
authors.affiliation: University of York, Heslington, York YO10 5DD, UK. richard.taylor@york.ac.uk william.unsworth@york.ac.uk.
authors.forename: Richard J K
authors.initials: RJ
authors.lastname: Taylor
authors.affiliation: University of York, Heslington, York YO10 5DD, UK. richard.taylor@york.ac.uk william.unsworth@york.ac.uk.
authors.forename: William P
authors.identifier: http://orcid.org/0000-0002-9169-5156
authors.initials: WP
authors.lastname: Unsworth