title: The using of a piglets as a model for evaluating the dipyrone hematological effects.
abstract: BACKGROUND
  Dipyrone (MET, metamizole) is a non-steroidal anti-inflammatory drug commonly used both in human and in veterinary medicine. After oral administration, is broken down rapidly to metabolites which largely retain the activity of the parent drug. Its metabolites have analgesic, antipyretic and anti-inflammatory effects.
  
  
  RESULTS
  The subjects were eight healthy male Large White post-suckling piglets, weighing between 5.0 to 7.4 kg, of ages 35 ± 10 days. The animals were administered MET (100 mg/kg) by an intramuscular (I.M.) injection. The study calculated the value of several hemorheological parameters. Significant impact of MET treatment (p < 0.05) was proven in case: activated partial thromboplastin time; ratio of activated partial thromboplastin time; hemoglobin; hematocrit; mean corpuscular hemoglobin; mean corpuscular volume; red blood cells volume; white blood cells volume; prothrombin time index.
  
  
  CONCLUSIONS
  In summation, our observations suggest that a piglet model is useful for studying the impact of MET on hemorheological parameters.
authors.affiliation: Department of Pharmacology, Faculty of Veterinary Medicine, University of Life Sciences, Akademicka 12, 20-033, Lublin, Poland. artur.burmanczuk@up.lublin.pl.
authors.forename: Artur
authors.identifier: http://orcid.org/0000-0002-2354-7696
authors.initials: A
authors.lastname: Burmańczuk
authors.affiliation: Department and Clinic of Animal Internal Diseases, Sub-Department of Companion Animal Internal Medicine, Faculty of Veterinary Medicine, University of Life Sciences, Głęboka 30, 20- 612, Lublin, Poland.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Milczak
authors.affiliation: Polpharma Biologics, Trzy lipy 3, 80-172, Gdańsk, Poland.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Grabowski
authors.affiliation: Department of Pharmacology, Faculty of Veterinary Medicine, University of Life Sciences, Akademicka 12, 20-033, Lublin, Poland.
authors.forename: Monika
authors.initials: M
authors.lastname: Osypiuk
authors.affiliation: Department of Pharmacology, Faculty of Veterinary Medicine, University of Life Sciences, Akademicka 12, 20-033, Lublin, Poland.
authors.forename: Cezary
authors.initials: C
authors.lastname: Kowalski
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000493:pharmacokinetics / Q000494:pharmacology*; D004177:Dipyrone / Q000493:pharmacokinetics / Q000494:pharmacology*; D006405:Hematology; D006439:Hemodynamics / Q000187:drug effects*; D008297:Male; D013552:Swine
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004177:Dipyrone
keywords: Dipyrone; Hematology; Metamizole; Piglet