title: Cumulative systolic blood pressure exposure in relation to cognitive function in middle-aged and elderly adults: A prospective, population-based study.
abstract: The association between systolic blood pressure (SBP) and cognitive function is controversial in elderly adults. In addition, few studies focused on the cumulative effect of SBP. We aimed to investigate the association between cumulative SBP exposure and cognitive function among middle-aged and elderly adults.The analysis was based on the Asymptomatic Polyvascular Abnormalities Community (APAC) study. The primary predictor was the cumulative SBP calculated by consecutive SBP values measured through baseline (2006-2007) up to the fourth examination (2012-2013). The cognitive function was estimated by mini-mental state examination (MMSE) in the fourth examination. Linear regression and logistic regression analyses were used to investigate the association between cumulative SBP and cognitive function.Among 2211 participants (41.4% female, aged 40-94 years), 167 (7.55%) were diagnosed with cognitive impairment (MMSE score < 24). Higher cumulative exposure to SBP (per SD increment) was independently associated with poor cognitive performance after controlling for multiple factors (P < 0.001). We observed nondifferential association between men and women. However, higher cumulative SBP in the adults aged ≥60 years had a stronger association with poor cognitive performance compared with that in adults aged 40 to 60 years.Greater exposure to cumulative SBP is associated with worse cognitive performance among middle-aged and elderly adults. This association is similar between men and women, but stronger in elderly adults.
authors.affiliation: Department of Cardiology, North China University of Science and Technology Affiliated Hospital Department of Neurology, Tangshan Gongren Hospital Department of Cardiology, Tangshan People's Hospital Department of Cardiology Department of Hepatobiliary Surgery, Kailuan Hospital, North China University of Science and Technology, Tangshan Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Liu
authors.forename: Yuling
authors.initials: Y
authors.lastname: Huang
authors.forename: Guojuan
authors.initials: G
authors.lastname: Chen
authors.forename: Xiaoxue
authors.initials: X
authors.lastname: Liu
authors.forename: Zhijun
authors.initials: Z
authors.lastname: Wang
authors.forename: Yibin
authors.initials: Y
authors.lastname: Cao
authors.forename: Haitao
authors.initials: H
authors.lastname: Li
authors.forename: Lu
authors.initials: L
authors.lastname: Song
authors.forename: Chunhui
authors.initials: C
authors.lastname: Li
authors.forename: Hualing
authors.initials: H
authors.lastname: Zhao
authors.forename: Shuohua
authors.initials: S
authors.lastname: Chen
authors.forename: Yiming
authors.initials: Y
authors.lastname: Wang
authors.forename: Ruiying
authors.initials: R
authors.lastname: Zhang
authors.forename: Anxin
authors.initials: A
authors.lastname: Wang
authors.forename: Shouling
authors.initials: S
authors.lastname: Wu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001794:Blood Pressure / Q000502:physiology*; D003071:Cognition / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013599:Systole