title: Physicochemical analysis in the evaluation of reconstituted dry emulsion tablets.
abstract: The aim of this study was to characterize the formation of emulsions by droplet size analysis and turbidimetry during reconstitution from a solid dosage form, namely from dry emulsion systems, which carry an oil phase for poorly soluble active ingredients. For the dry emulsion systems tablets were prepared either from oil-in-water systems using a freeze-drying process or through direct compression containing the same oil and excipients. The ratios of oil to emulgents and oil to xanthan gum were equal in both methods. In the preparation methods applied, mannitol, erythritol and lactose were used as excipients and mannitol was found to be the most effective excipient based on droplet size reconstitution, turbidimetry and physical properties. Quality control involved testing the physical properties of tablets and characterizing the reconstituted emulsions.
authors.affiliation: Department of Pharmaceutics, Semmelweis University, 7 Hőgyes Endre Str., H-1092 Budapest, Hungary.
authors.forename: Noémi Anna
authors.initials: NA
authors.lastname: Niczinger
authors.affiliation: Department of Pharmaceutics, Semmelweis University, 7 Hőgyes Endre Str., H-1092 Budapest, Hungary.
authors.forename: Barnabás
authors.initials: B
authors.lastname: Kállai-Szabó
authors.affiliation: Department of Pharmaceutics, Semmelweis University, 7 Hőgyes Endre Str., H-1092 Budapest, Hungary.
authors.forename: Miléna
authors.initials: M
authors.lastname: Lengyel
authors.affiliation: Department of Electronics Technology, Budapest University of Technology and Economics, 18 Egry J. Str., H-1111 Budapest, Hungary.
authors.forename: Péter
authors.initials: P
authors.lastname: Gordon
authors.affiliation: Department of Pharmaceutics, Semmelweis University, 7 Hőgyes Endre Str., H-1092 Budapest, Hungary.
authors.forename: Imre
authors.initials: I
authors.lastname: Klebovich
authors.affiliation: Department of Pharmaceutics, Semmelweis University, 7 Hőgyes Endre Str., H-1092 Budapest, Hungary. Electronic address: antal.istvan@pharma.semmelweis-univ.hu.
authors.forename: István
authors.initials: I
authors.lastname: Antal
mesh_terms: D055598:Chemical Phenomena; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D019245:Compressive Strength; D004353:Drug Evaluation, Preclinical / Q000379:methods; D004655:Emulsions / Q000032:analysis* / Q000737:chemistry*; D005079:Excipients / Q000032:analysis / Q000737:chemistry; D005612:Freeze Drying / Q000379:methods; D009391:Nephelometry and Turbidimetry / Q000379:methods; D011135:Polysaccharides, Bacterial / Q000032:analysis / Q000737:chemistry; D013607:Tablets / Q000032:analysis* / Q000737:chemistry*
chemical_list: D004655:Emulsions; D005079:Excipients; D011135:Polysaccharides, Bacterial; D013607:Tablets; C002563:xanthan gum
keywords: Contact angle; Laser diffraction; Olive oil; Required HLB; Scanning microscopy; Turbidimetry