title: [Value of urinary liver fatty acid-binding protein in assessing severity of brain trauma and predicting acute kidney injury].
abstract: OBJECTIVE
  To assess the value of urinary liver-type fatty acid-binding protein (L-FABP) in early assessment of the severity of traumatic brain injury and in predicting the occurrence of acute kidney injury (AKI) following the brain injury.
  
  
  METHODS
  Sixty-five patients with traumatic brain injury patients were divided into 4 groups according to their Glasgow coma scale (GCS) scores. Blood and urine samples were collected at 2, 6, 12, 24, 48 and 72 h after the injury to detect serum creatinine (SCr) level using biochemical analyzer and urinary L-FABP using enzyme-linked immunosorbent assay (ELISA), with samples from 15 healthy adults as controls. The correlations were analyzed among SCr, urinary L-FABP, GCS score upon admission and AKI occurrence.
  
  
  RESULTS
  The patients with moderate to severe brain injuries showed significantly higher SCr and urinary L-FABP levels than the control group (P<0.05). GCS score of the patients was inversely correlated with the levels of SCr and urinary L-FABP (P<0.05), and the changes were more prominent in urinary L-FABP than in SCr. The incidence of AKI was 21.54% in these patients. In patients with AKI, urinary L-FABP reached the peak level as soon as 6 h after the injury, as compared with 24 to 48 h when peak SCr level occurred.
  
  
  CONCLUSIONS
  Urinary L-FABP can be used as a marker for early assessment of the severity of traumatic brain injury and for predicting the occurrence of AKI following the injury.
authors.affiliation: Department of Neurosurgery, Third Xiangya Hospital of Central South University, Changsha 410013, China.E-mail: gywu7508@163.com.
authors.forename: Guang-Yong
authors.initials: GY
authors.lastname: Wu
authors.forename: Kai
authors.initials: K
authors.lastname: Zhuang
authors.forename: Yu
authors.initials: Y
authors.lastname: Liu
authors.forename: Zhi-Fei
authors.initials: ZF
authors.lastname: Wang
mesh_terms: D058186:Acute Kidney Injury / Q000175:diagnosis* / Q000652:urine; D000328:Adult; D015415:Biomarkers / Q000652:urine; D000070642:Brain Injuries, Traumatic / Q000175:diagnosis* / Q000652:urine; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D050556:Fatty Acid-Binding Proteins / Q000652:urine*; D006801:Humans; D007677:Kidney Function Tests
chemical_list: D015415:Biomarkers; C493319:FABP1 protein, human; D050556:Fatty Acid-Binding Proteins