title: Functional Connectivity Analysis of Brain Default Mode Networks Using Hamiltonian Path.
abstract: The aim of this study is to introduce Hamiltonian path to analyze functional connectivity of brain default mode networks (DMNs). Firstly, the brain DMNs in resting state are constructed with the employment of functional Magnetic Resonance Imaging (fMRI) data. Then, the Dijkstra algorithm is used to calculate the shortest path length of the node which represents each brain region, and the Hamiltonian path of the default network is solved through the improved adaptive ant colony algorithm. Finally, complex network analysis methods are introduced to discuss the node and network properties of brain functional connectivity in both normal subjects and stroke patients. The experimental result demonstrated that there are some significant differences in the properties of the DMNs between stroke patients and normal subjects, especially the length of Hamiltonian path. It also verifies the effectiveness on studying the functional connectivity of the brain DMNs by applying the proposed method of Hamiltonian path.
authors.forename: Zhuqing
authors.initials: Z
authors.lastname: Jiao
authors.forename: Kai
authors.initials: K
authors.lastname: Ma
authors.forename: Huan
authors.initials: H
authors.lastname: Wang
authors.affiliation: School of Information Science and Engineering, Changzhou University, Changzhou, 213164,. China.
authors.forename: Ling
authors.initials: L
authors.lastname: Zou
authors.affiliation: School of Information Science and Engineering, Changzhou University, Changzhou, 213164,. China.
authors.forename: Jianbo
authors.initials: J
authors.lastname: Xiang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000465:Algorithms; D001921:Brain / Q000033:anatomy & histology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D009415:Nerve Net / Q000033:anatomy & histology / Q000000981:diagnostic imaging; D009434:Neural Pathways / Q000033:anatomy & histology* / Q000000981:diagnostic imaging; D020521:Stroke / Q000000981:diagnostic imaging; D055815:Young Adult
keywords: Ant colony algorithm; Hamiltonian path.; brain functional connectivity; complex network; default mode networks; functional magnetic
  resonance imaging