title: Olanzapine modulation of long- and short-range functional connectivity in the resting brain in a sample of patients with schizophrenia.
abstract: Treatment effects of antipsychotic drugs on cerebral function are seldom examined. Exploring functional connectivity (FC) in drug-free schizophrenia patients before and after antipsychotic treatment can improve the understanding of antipsychotic drug mechanisms. A total of 17 drug-free patients with recurrent schizophrenia and 24 healthy controls underwent resting-state functional magnetic resonance imaging scans. Long- and short-range FC strengths (FCS) were calculated for each participant. Compared with the controls, the patients at baseline exhibited increased long-range positive FCS (lpFCS) in the bilateral inferior parietal lobule (IPL) and decreased lpFCS in the brain regions of the default-mode network (DMN) regions and sensorimotor circuits of the brain. By contrast, increased short-range positive FCS was observed in the right IPL of the patients at baseline compared with the controls. After treatment with olanzapine, increased FC in the DMN and sensorimotor circuits of the brain was noted, whereas decreased FC was observed in the left superior temporal gyrus (STG). Moreover, the alterations of the FCS values and the reductions in symptom severity among the patients after treatment were correlated. The present study provides evidence that olanzapine normalizes the abnormalities of long- and short-range FCs in schizophrenia. FC reductions in the right IPL may be associated with early treatment response, whereas those in the left STG may be related to poor treatment outcome.
authors.affiliation: Department of Psychiatry, the Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China; Mental Health Institute of the Second Xiangya Hospital, Central South University, China; National Clinical Research Center on Mental Disorders, China; National Technology Institute on Mental Disorders, China; Hunan Key Laboratory of Psychiatry and Mental Health, China. Electronic address: guowenbin76@163.com.
authors.forename: Wenbin
authors.initials: W
authors.lastname: Guo
authors.affiliation: Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Liu
authors.affiliation: Department of Psychiatry, the Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China; Mental Health Institute of the Second Xiangya Hospital, Central South University, China; National Clinical Research Center on Mental Disorders, China; National Technology Institute on Mental Disorders, China; Hunan Key Laboratory of Psychiatry and Mental Health, China.
authors.forename: Jindong
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Psychiatry, the Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China; Mental Health Institute of the Second Xiangya Hospital, Central South University, China; National Clinical Research Center on Mental Disorders, China; National Technology Institute on Mental Disorders, China; Hunan Key Laboratory of Psychiatry and Mental Health, China.
authors.forename: Renrong
authors.initials: R
authors.lastname: Wu
authors.affiliation: Department of Psychiatry, the Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China; Mental Health Institute of the Second Xiangya Hospital, Central South University, China; National Clinical Research Center on Mental Disorders, China; National Technology Institute on Mental Disorders, China; Hunan Key Laboratory of Psychiatry and Mental Health, China.
authors.forename: Lehua
authors.initials: L
authors.lastname: Li
authors.affiliation: Mental Health Center, the First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi 530021, China.
authors.forename: Zhikun
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Psychiatry, the Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China; Mental Health Institute of the Second Xiangya Hospital, Central South University, China; National Clinical Research Center on Mental Disorders, China; National Technology Institute on Mental Disorders, China; Hunan Key Laboratory of Psychiatry and Mental Health, China. Electronic address: zhaojingpingcsu@163.com.
authors.forename: Jingping
authors.initials: J
authors.lastname: Zhao
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001569:Benzodiazepines / Q000627:therapeutic use*; D001921:Brain / Q000000981:diagnostic imaging / Q000187:drug effects*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008959:Models, Neurological; D009434:Neural Pathways / Q000000981:diagnostic imaging / Q000187:drug effects / Q000502:physiology*; D000077152:Olanzapine; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology*; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D014150:Antipsychotic Agents; D001569:Benzodiazepines; D000077152:Olanzapine
keywords: Anatomical distance; Default-mode network; Functional connectivity; Olanzapine; Schizophrenia