title: Low-dose radiotherapy for primary cutaneous anaplastic large-cell lymphoma while on low-dose methotrexate.
abstract: Primary cutaneous anaplastic large-cell lymphoma (pcALCL) is part of a spectrum of CD30+ primary cutaneous lymphoproliferative disorders (pcLPDs) that also includes lymphomatoid papulosis (LyP). Localized radiotherapy at doses of 34 to 44 Gy is first-line treatment of pcALCL, but the use of low-dose radiotherapy for pcALCL has not been reported. We present the case of a patient with a history of pcALCL/LyP who was treated with low-dose radiotherapy while on oral low-dose methotrexate (MTX) once weekly. This report suggests that low-dose radiotherapy can be an effective palliative treatment of pcALCL. Low-dose radiotherapy may offer certain advantages over traditional radiotherapy, such as a more economical and efficient treatment for patients, potentially fewer short-term and long-term side effects, and the potential for concomitant use with low-dose MTX.
authors.affiliation: Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, USA.
authors.forename: Christine M
authors.initials: CM
authors.lastname: Cornejo
authors.affiliation: Department of Dermatology, Stanford University School of Medicine, California, USA.
authors.forename: Roberto A
authors.initials: RA
authors.lastname: Novoa
authors.affiliation: Department of Radiation Oncology, Chester County Hospital, West Chester, Pennsylvania, USA.
authors.forename: Robert E
authors.initials: RE
authors.lastname: Krisch
authors.affiliation: Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, USA.
authors.forename: Ellen J
authors.initials: EJ
authors.lastname: Kim
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use*; D059248:Chemoradiotherapy / Q000379:methods*; D005260:Female; D006258:Head and Neck Neoplasms / Q000473:pathology / Q000628:therapy*; D006801:Humans; D054446:Lymphoma, Primary Cutaneous Anaplastic Large Cell / Q000473:pathology / Q000628:therapy*; D008727:Methotrexate / Q000627:therapeutic use*; D008875:Middle Aged; D011878:Radiotherapy; D012878:Skin Neoplasms / Q000473:pathology / Q000628:therapy*
chemical_list: D000964:Antimetabolites, Antineoplastic; D008727:Methotrexate