title: Genetic polymorphism studies on 22 autosomal STR loci of the PowerPlex Fusion System in Bangladeshi population.
abstract: Genetic polymorphism of 22 autosomal STR loci included in PowerPlex® Fusion System (D3S1358, D1S1656, D2S441, D10S1248, D13S317, Penta E, D16S539, D18S51, D2S1338, CSF1PO, Penta D, TH01, vWA, D21S11, D7S820, D5S818, TPOX, D8S1179, D12S391, D19S433, FGA and D22S1045) was studied in 188 unrelated Bangladeshi Bengali individuals. Allele frequencies and forensic efficiency parameters such as, the power of discrimination (PD), observed and expected heterozygosity (Ho & He), polymorphism information content (PIC), probability of match (PM), power of exclusion (PE) and typical paternity index was calculated for the loci. The combined PM and PE for all 22 STR loci were calculated to be 5.29×10-27and 0.99999999945 respectively. The dataset indicated the usefulness of these loci in personal identification, parentage testing and complex kinship analysis in Bangladeshi population. A neighbor-joining tree was constructed based on pair-wise Nei's genetic distance by comparing allele frequency data for the 22 loci with six other populations. The analysis showed that Bangladeshi population lies closer to a clade consisting Japan, the Philippines and East Timot populations.
authors.affiliation: National Forensic DNA Profiling Laboratory, Dhaka Medical College, Dhaka 1000, Bangladesh.
authors.forename: Tania
authors.initials: T
authors.lastname: Hossain
authors.affiliation: National Forensic DNA Profiling Laboratory, Dhaka Medical College, Dhaka 1000, Bangladesh.
authors.forename: Mahamud
authors.initials: M
authors.lastname: Hasan
authors.affiliation: National Forensic DNA Profiling Laboratory, Dhaka Medical College, Dhaka 1000, Bangladesh.
authors.forename: Ashish K
authors.initials: AK
authors.lastname: Mazumder
authors.affiliation: National Forensic DNA Profiling Laboratory, Dhaka Medical College, Dhaka 1000, Bangladesh.
authors.forename: Pilu
authors.initials: P
authors.lastname: Momtaz
authors.affiliation: National Forensic DNA Profiling Laboratory, Dhaka Medical College, Dhaka 1000, Bangladesh.
authors.forename: Abu
authors.initials: A
authors.lastname: Sufian
authors.affiliation: National Forensic DNA Profiling Laboratory, Dhaka Medical College, Dhaka 1000, Bangladesh.
authors.forename: Jabedul Alam
authors.initials: JA
authors.lastname: Khandaker
authors.affiliation: Department of Genetic Engineering & Biotechnology, University of Dhaka, Dhaka 1000, Bangladesh. Electronic address: sazaman@du.ac.bd.
authors.forename: Sharif
authors.initials: S
authors.lastname: Akhteruzzaman
mesh_terms: D001459:Bangladesh; D030541:Databases, Genetic; D005787:Gene Frequency; D005828:Genetics, Population; D006801:Humans; D018895:Microsatellite Repeats; D011110:Polymorphism, Genetic
keywords: Allele frequency; Autosomal STR; Bangladeshi; PowerPlex® Fusion