title: Influence of TP53 Codon 72 Polymorphism Alone or in Combination with HDM2 SNP309 on Human Infertility and IVF Outcome.
abstract: To evaluate the association of the TP53 codon 72 (rs 1042522) alone or in combination with HDM2 SNP309 (rs 2279744) polymorphisms with human infertility and IVF outcome, we collected 1450 infertility women undergoing their first controlled ovarian stimulation for IVF treatment and 250 fertile controls in the case-control study. Frequencies, distribution, interaction of genes, and correlation with infertility and IVF outcome of clinical pregnancy were analyzed. We found a statistically significant association between TP53 codon 72 polymorphism and IVF outcome (52.10% vs. 47.40%, OR = 0.83, 95%CI:0.71-0.96, p = 0.01). No significant difference was shown between TP53 codon 72, HDM2 SNP309 polymorphisms, human infertility, and between the combination of two genes polymorphisms and the clinical pregnancy outcome of IVF. The data support C allele as a protective factor for IVF pregnancy outcome. Further researches should be focused on the mechanism of these associations.
authors.affiliation: Genetic Diagnosis Center, Yunnan Provincial Key Laboratory For Birth Defects and Genetic Diseases, The First People's Hospital of Yunnan Province, Kunming, Yunnan, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Chan
authors.affiliation: Genetic Diagnosis Center, Yunnan Provincial Key Laboratory For Birth Defects and Genetic Diseases, The First People's Hospital of Yunnan Province, Kunming, Yunnan, China.
authors.forename: Baosheng
authors.initials: B
authors.lastname: Zhu
authors.affiliation: Lab of Molecular Genetics of Aging & Tumor, Faculty of Medicine, Kunming University of Science and Technology, Kunming, Yunnan, China.
authors.forename: Hongguo
authors.initials: H
authors.lastname: Jiang
authors.affiliation: Genetic Diagnosis Center, Yunnan Provincial Key Laboratory For Birth Defects and Genetic Diseases, The First People's Hospital of Yunnan Province, Kunming, Yunnan, China.
authors.forename: Jinman
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Lab of Molecular Genetics of Aging & Tumor, Faculty of Medicine, Kunming University of Science and Technology, Kunming, Yunnan, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Luo
authors.affiliation: Lab of Molecular Genetics of Aging & Tumor, Faculty of Medicine, Kunming University of Science and Technology, Kunming, Yunnan, China.
authors.forename: Wenru
authors.initials: W
authors.lastname: Tang
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D003062:Codon / Q000235:genetics*; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D005838:Genotype; D006801:Humans; D007247:Infertility, Female / Q000235:genetics*; D010062:Ovulation Induction; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011247:Pregnancy; D011256:Pregnancy Outcome; D051736:Proto-Oncogene Proteins c-mdm2 / Q000235:genetics*; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
chemical_list: D003062:Codon; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53; C497206:MDM2 protein, human; D051736:Proto-Oncogene Proteins c-mdm2