title: MicroRNA-142 is a multifaceted regulator in organogenesis, homeostasis, and disease.
abstract: Over the past decade, microRNA-142 (miR-142) is emerging as a major regulator of cell fate decision in the hematopoietic system. However, miR-142 is expressed in many other tissues, and recent evidence suggests that it may play a more pleiotropic role during embryonic development. In addition, miR-142 has been shown to play important functions in disease. miR-142 displays a functional role in cancer, virus infection, inflammation, and immune tolerance. Both a guide strand (miR-142-3p) and passenger strand (miR-142-5p) are generated from the miR-142 hairpin. miR-142-3p and -5p display overlapping but also independent target genes. Loss of function mouse models (genetrap, global knock out [KO], and conditional KO) have been reported and support the important role of miR-142 in different biological processes. This review will summarize the abundant literature already available for miR-142 and will lay the foundation for future works on this important microRNA. Developmental Dynamics 246:285-290, 2017. © 2016 Wiley Periodicals, Inc.
authors.affiliation: German Center for Lung Research, Excellence Cluster Cardio-Pulmonary System, Universities of Giessen and Marburg Lung Center, Giessen, Hessen, Germany.
authors.forename: Amit
authors.initials: A
authors.lastname: Shrestha
authors.affiliation: Institute of Fundamental Medicine and Biology. Kazan (Volga Region) Federal University, Kazan, Russian Federation.
authors.forename: Regina T
authors.initials: RT
authors.lastname: Mukhametshina
authors.affiliation: German Center for Lung Research, Excellence Cluster Cardio-Pulmonary System, Universities of Giessen and Marburg Lung Center, Giessen, Hessen, Germany.
authors.forename: Sara
authors.initials: S
authors.lastname: Taghizadeh
authors.affiliation: Universidad Autonoma "Benito Juarez" de Oaxaca, Av. Universidad s/n cinco senores, Oaxaca, Mexico.
authors.forename: Esmeralda
authors.initials: E
authors.lastname: Vásquez-Pacheco
authors.affiliation: Cardiovascular & Metabolic Diseases Program, Duke-NUS Graduate Medical School Singapore, Singapore.|Institute of Biochemistry, Justus-Liebig-University Giessen, Germany.
authors.forename: Hector
authors.initials: H
authors.lastname: Cabrera-Fuentes
authors.affiliation: Institute of Fundamental Medicine and Biology. Kazan (Volga Region) Federal University, Kazan, Russian Federation.
authors.forename: Albert
authors.identifier: 0000-0002-9427-5739
authors.initials: A
authors.lastname: Rizvanov
authors.affiliation: Institut de Pharmacologie Moléculaire et Cellulaire (IPMC), Centre National de la Recherche Scientifique, CNRS, UMR 7275, Sophia Antipolis, France.|Université Côte d'Azur, France.
authors.forename: Bernard
authors.initials: B
authors.lastname: Mari
authors.affiliation: Lung and Regenerative Medicine Institutes, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California.
authors.forename: Gianni
authors.initials: G
authors.lastname: Carraro
authors.affiliation: German Center for Lung Research, Excellence Cluster Cardio-Pulmonary System, Universities of Giessen and Marburg Lung Center, Giessen, Hessen, Germany.|Institute of Fundamental Medicine and Biology. Kazan (Volga Region) Federal University, Kazan, Russian Federation.
authors.forename: Saverio
authors.initials: S
authors.lastname: Bellusci
mesh_terms: D000818:Animals; D006706:Homeostasis; D006801:Humans; D007108:Immune Tolerance / Q000235:genetics; D007249:Inflammation / Q000235:genetics; D051379:Mice; D035683:MicroRNAs / Q000502:physiology*; D009369:Neoplasms / Q000235:genetics; D038081:Organogenesis
chemical_list: C555159:MIRN142 microRNA, human; D035683:MicroRNAs; C529102:Mirn142 microRNA, mouse
keywords: ERK; WNT signaling; development; disease; miR-142; stem cells