title: XTalkDB: a database of signaling pathway crosstalk.
abstract: Analysis of signaling pathways and their crosstalk is a cornerstone of systems biology. Thousands of papers have been published on these topics. Surprisingly, there is no database that carefully and explicitly documents crosstalk between specific pairs of signaling pathways. We have developed XTalkDB (http://www.xtalkdb.org) to fill this very important gap. XTalkDB contains curated information for 650 pairs of pathways from over 1600 publications. In addition, the database reports the molecular components (e.g. proteins, hormones, microRNAs) that mediate crosstalk between a pair of pathways and the species and tissue in which the crosstalk was observed. The XTalkDB website provides an easy-to-use interface for scientists to browse crosstalk information by querying one or more pathways or molecules of interest.
authors.affiliation: Department of Biological Sciences, Virginia Tech, Blacksburg, VA 24061, USA.|School of Neuroscience, Virginia Tech, Blacksburg, VA 24061, USA.
authors.forename: Sarah A
authors.initials: SA
authors.lastname: Sam
authors.affiliation: Department of Biological Sciences, Virginia Tech, Blacksburg, VA 24061, USA.
authors.forename: Joelle
authors.initials: J
authors.lastname: Teel
authors.affiliation: Department of Computer Science, Virginia Tech, Blacksburg, VA 24061, USA.|Department of Statistics, Virginia Tech, Blacksburg, VA 24061, USA.
authors.forename: Allison N
authors.initials: AN
authors.lastname: Tegge
authors.affiliation: Department of Computer Science, Virginia Tech, Blacksburg, VA 24061, USA.
authors.forename: Aditya
authors.initials: A
authors.lastname: Bharadwaj
authors.affiliation: Department of Computer Science, Virginia Tech, Blacksburg, VA 24061, USA murali@cs.vt.edu.|ICTAS Center for Systems Biology of Engineered Tissues, Virginia Tech, Blacksburg, VA 24061, USA.
authors.forename: T M
authors.initials: TM
authors.lastname: Murali
mesh_terms: D019295:Computational Biology / Q000379:methods*; D030541:Databases, Genetic; D005786:Gene Expression Regulation; D008024:Ligands; D011485:Protein Binding; D011506:Proteins; D015398:Signal Transduction; D012984:Software; D049490:Systems Biology / Q000379:methods; D064878:Web Browser
chemical_list: D008024:Ligands; D011506:Proteins