title: Synthesis, characterization and antibacterial activity of superparamagnetic nanoparticles modified with glycol chitosan.
abstract: Iron oxide nanoparticles (IONPs) were synthesized by coprecipitation of iron salts in alkali media followed by coating with glycol chitosan (GC-coated IONPs). Both bare and GC-coated IONPs were subsequently characterized and evaluated for their antibacterial activity. Comparison of Fourier transform infrared spectra and thermogravimetric data of bare and GC-coated IONPs confirmed the presence of GC coating on IONPs. Magnetization curves showed that both bare and GC-coated IONPs are superparamagnetic and have saturation magnetizations of 70.3 and 59.8 emu g-1, respectively. The IONP size was measured as ∼8-9 nm by transmission electron microscopy, and their crystal structure was assigned to magnetite from x-ray diffraction patterns. Both bare and GC-coated IONPs inhibited the growths ofEscherichia coliATCC 8739 andSalmonella enteritidisSE 01 bacteria better than the antibiotics linezolid and cefaclor, as evaluated by the agar dilution assay. GC-coated IONPs showed higher potency againstE. coliO157:H7 andStaphylococcus aureusATCC 10832 than bare IONPs. Given their biocompatibility and antibacterial properties, GC-coated IONPs are a potential nanomaterial forin vivoapplications.
authors.affiliation: Department of Food Science, Fu Jen University, Taipei 242, Taiwan.
authors.forename: Baskaran
authors.initials: B
authors.lastname: Stephen Inbaraj
authors.affiliation: Department of Food Science, Fu Jen University, Taipei 242, Taiwan.
authors.forename: Tsung-Yu
authors.initials: TY
authors.lastname: Tsai
authors.affiliation: Department of Food Science, Fu Jen University, Taipei 242, Taiwan; Graduate Institute of Medicine, Fu Jen University, Taipei 242, Taiwan.
authors.forename: Bing-Huei
authors.initials: BH
authors.lastname: Chen
keywords: Antibacterial activity; Coating material; Glycol chitosan; Iron oxide nanoparticles; Superparamagnetic