title: [Alzheimer's disease cerebro-spinal fluid biomarkers: A clinical research tool sometimes useful in daily clinical practice of memory clinics for the diagnosis of complex cases].
abstract: The role of biomarkers in clinical research was recently highlighted in the new criteria for the diagnosis of Alzheimer's disease. Cerebro-spinal fluid (CSF) biomarkers (total Tau protein, threonine 181 phosphorylated Tau protein and amyloid Aβ1-42 peptide) are associated with cerebral neuropathological lesions observed in Alzheimer's disease (neuronal death, neurofibrillary tangle with abnormal Tau deposits and amyloid plaque). Aβ1-40 amyloid peptide dosage helps to interpret Aβ1-42 results. As suggested in the latest international criteria and the French HAS (Haute Autorité de santé) recommendations, using theses CSF biomarkers should not be systematic but sometimes could be performed to improve confidence about the diagnostic of Alzheimer's disease in young subjects or in complex clinical situations. Future biomarkers actually in development will additionally help in diagnostic process (differential diagnosis) and in prognostic evaluation of neurodegenerative diseases.
authors.affiliation: Centre mémoire de recherches et de ressource de Besançon, CHU de Besançon, 25030 Besançon, France. Electronic address: eloi.magnin@laposte.net.
authors.forename: E
authors.initials: E
authors.lastname: Magnin
authors.affiliation: Centre mémoire de recherches et de ressource Paris Nord Île-de-France, université Paris Diderot, Sorbonne Paris Cité, Inserm U942, groupe hospitalier Saint-Louis-Lariboisière-Fernand-Widal, AP-HP, 75205 Paris, France.
authors.forename: J
authors.initials: J
authors.lastname: Dumurgier
authors.affiliation: Service de biochimie et biologie moléculaire, université Paris-Descartes, Inserm UMRS-1144, groupe hospitalier Saint-Louis-Lariboisière-Fernand Widal, AP-HP, 75205 Paris, France.
authors.forename: E
authors.initials: E
authors.lastname: Bouaziz-Amar
authors.affiliation: Centre mémoire de recherches et de ressource, CHU de Lille, 59000 Lille, France.
authors.forename: S
authors.initials: S
authors.lastname: Bombois
authors.affiliation: Centre mémoire de recherches et de ressource, CHU de Rouen, 76000 Rouen, France.
authors.forename: D
authors.initials: D
authors.lastname: Wallon
authors.affiliation: Centre mémoire de recherches et de ressource de Montpellier, CHU de Montpelier, 34000 Montpellier, France.
authors.forename: A
authors.initials: A
authors.lastname: Gabelle
authors.affiliation: Laboratoire de biochimie-protéomique clinique, IRMB, CCBHM, Inserm U11183, hôpital Saint-Éloi, université Montpellier, CHU de Montpellier, 34000 Montpellier cedex, France.
authors.forename: S
authors.initials: S
authors.lastname: Lehmann
authors.affiliation: CMRR, service de gériatre, CHU, 67000 Strasbourg, France.
authors.forename: F
authors.initials: F
authors.lastname: Blanc
authors.affiliation: Laboratoire de biochimie et de biologie moléculaire, CHU, 67000 Strasbourg, France.
authors.forename: O
authors.initials: O
authors.lastname: Bousiges
authors.affiliation: Centre mémoire de recherches et de ressource, CHU de Rouen, 76000 Rouen, France.
authors.forename: D
authors.initials: D
authors.lastname: Hannequin
authors.affiliation: CMRR, service de gériatre, CHU, 67000 Strasbourg, France.
authors.forename: B
authors.initials: B
authors.lastname: Jung
authors.affiliation: Laboratoire de pharmacologie clinique, CHU, 25000 Besançon, France.
authors.forename: C
authors.initials: C
authors.lastname: Miguet-Alfonsi
authors.affiliation: Service de biochimie, hôpital universitaire de Rouen, 76000 Rouen, France.
authors.forename: M
authors.initials: M
authors.lastname: Quillard
authors.affiliation: Centre mémoire de recherches et de ressource, CHU de Lille, 59000 Lille, France.
authors.forename: F
authors.initials: F
authors.lastname: Pasquier
authors.affiliation: Service de biochimie clinique, hôpital Beaujon, AP-HP, 92110 Clichy, France.
authors.forename: K
authors.initials: K
authors.lastname: Peoc'h
authors.affiliation: Service de biochimie et biologie moléculaire, université Paris-Descartes, Inserm UMRS-1144, groupe hospitalier Saint-Louis-Lariboisière-Fernand Widal, AP-HP, 75205 Paris, France.
authors.forename: J-L
authors.initials: JL
authors.lastname: Laplanche
authors.affiliation: Centre mémoire de recherches et de ressource Paris Nord Île-de-France, université Paris Diderot, Sorbonne Paris Cité, Inserm U942, groupe hospitalier Saint-Louis-Lariboisière-Fernand-Widal, AP-HP, 75205 Paris, France.
authors.forename: J
authors.initials: J
authors.lastname: Hugon
authors.affiliation: Centre mémoire de recherches et de ressource Paris Nord Île-de-France, université Paris Diderot, Sorbonne Paris Cité, Inserm U942, groupe hospitalier Saint-Louis-Lariboisière-Fernand-Widal, AP-HP, 75205 Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Paquet
mesh_terms: D000544:Alzheimer Disease / Q000134:cerebrospinal fluid* / Q000175:diagnosis*; D016229:Amyloid beta-Peptides / Q000134:cerebrospinal fluid; D015415:Biomarkers / Q000134:cerebrospinal fluid*; D035843:Biomedical Research / Q000379:methods / Q000639:trends; D003704:Dementia / Q000134:cerebrospinal fluid / Q000175:diagnosis*; D003937:Diagnosis, Differential; D006801:Humans; D008568:Memory / Q000502:physiology; D010818:Practice Patterns, Physicians'; D016875:tau Proteins / Q000134:cerebrospinal fluid
chemical_list: D016229:Amyloid beta-Peptides; D015415:Biomarkers; D016875:tau Proteins
keywords: Alzheimer's disease; Biomarkers; Biomarqueurs; Cerebro-spinal fluid; Liquide cérébro-spinal; Lumbar puncture; Maladie d’Alzheimer; Ponction lombaire