title: Kanahia Laniflora Methanolic Extract Suppressed Proliferation of Human Non-Small Cell Lung Cancer A549 Cells
abstract: Introduction: Lung cancer is one of the most common cancers worldwide. In certain countries such as United
  States of America, it is the leading cause of related cancer mortality among both men and women. Natural products
  play an important role in overcoming the limitations of chemotherapy and radiotherapy. Objectives: In this study,
  we investigated the antiproliferative and apoptotic activities of Kanahia laniflora methanolic extract against human
  non-small cell lung cancer cells (A549). Methods: Sulforhodamine B colorimetric assays were used to determine
  the inhibitory effects of a leaf methanolic extract against A549 cells. Results: The extract showed strong cytotoxic
  activity against A549 cells with an IC50 value of 0.13 μg/ml compared to 0.21 μg/ml for doxorubicin. The extract also
  significantly increased the percentage of apoptotic cells to 49.7% as compared to 1.4% and 47.4% for control and
  doxorubicin respectively. Conclusion: These results showed, for the first time, that a methanolic extract of Kanahia
  laniflora leaves can inhibit the proliferation of human non-small cell lung cancer cells (A549). Further attention to its
  potential as a new effective anticancer agent is warranted.
authors.affiliation: Biology Department, Faculty of Science, King Khalid University, Abha 9004, Kingdom of Saudi Arabia. Email: alfaifi@kku.edu.sa
authors.forename: Mohammad Yahya
authors.initials: MY
authors.lastname: Alfaifi
keywords: Lung cancer; A549; kanahia laniflora; apoptosis; herbal medicine