title: Two cervical preparation regimens prior to surgical abortion at 10-14 weeks of gestation: A randomized clinical trial.
abstract: BACKGROUND
  The aim of the study was to determine whether same-day cervical preparation with an osmotic dilator and misoprostol was as effective and safe as overnight cervical preparation for surgical abortions at 10-14 weeks.
  
  
  METHODS
  Seventy women seeking surgical abortion at 10-14 weeks were allocated to receive one osmotic dilator 16-17 h or 6-7 h prior to an abortion. All women received misoprostol 400 μg orally 2 h before the abortion.
  
  
  RESULTS
  The abortion time of the same-day group was 7.42 ± 1.73 min, and that of the overnight group was 8.00 ± 2.19 min (p = 0.23). The blood loss volume of the same-day group was 20.6 ± 10.6 mL, and that of the overnight group was 16.3 ± 7.0 mL (p = 0.55). The degree of cervical dilation for the same-day group was inferior to the overnight group (p = 0.02).
  
  
  CONCLUSIONS
  Same-day cervical preparation with misoprostol and an osmotic dilator shortens the hospitalization days, suggesting same-day cervical preparation is safe, effective, and feasible for surgical abortion at 10-14 weeks of gestation.
authors.affiliation: a Department of Obstetrics and Gynecology , Women's Hospital School of Medicine, Zhejiang University , Hangzhou , China.
authors.forename: Qingyun
authors.initials: Q
authors.lastname: Guo
authors.affiliation: a Department of Obstetrics and Gynecology , Women's Hospital School of Medicine, Zhejiang University , Hangzhou , China.
authors.forename: Zhida
authors.initials: Z
authors.lastname: Qian
authors.affiliation: a Department of Obstetrics and Gynecology , Women's Hospital School of Medicine, Zhejiang University , Hangzhou , China.
authors.forename: Lili
authors.initials: L
authors.lastname: Huang
mesh_terms: D000020:Abortifacient Agents, Nonsteroidal / Q000008:administration & dosage; D000028:Abortion, Induced / Q000379:methods*; D000282:Administration, Intravaginal; D000328:Adult; D002584:Cervix Uteri / Q000187:drug effects / Q000502:physiology; D003131:Combined Modality Therapy; D004106:Dilatation / Q000379:methods*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D016595:Misoprostol / Q000008:administration & dosage*; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011300:Preoperative Care / Q000379:methods*; D013997:Time Factors; D055815:Young Adult
chemical_list: D000020:Abortifacient Agents, Nonsteroidal; D016595:Misoprostol
keywords: Cervical preparation; misoprostol; osmotic dilator; surgical abortion