title: Controlled extended octenidine release from a bacterial nanocellulose/Poloxamer hybrid system.
abstract: Although bacterial nanocellulose (BNC) has been widely investigated in the last 10years as drug delivery system, up to now no long-term controlled release of drugs could be realized. Therefore, the aim of the present work was the development of a BNC-based drug delivery system that provides prolonged retention time for the antiseptic octenidine up to one week with improved mechanical and antimicrobial properties as well as a high biocompatibility. BNC was modified by incorporation of differently concentrated Poloxamers 338 and 407 as micelles and gels that were extensively investigated regarding size, surface charge, and dynamic viscosity. Depending on type and concentration of the Poloxamer, a retarded octenidine release up to one week could be accomplished. Additionally, superior material properties such as high compression stability and water binding could be achieved. The antimicrobial activity of octenidine against Staphylococcus aureus and Pseudomonas aeruginosa was not changed by the use of Poloxamers. Excellent biocompatibility of the Poloxamer loaded BNC could be demonstrated after local administration in a shell-less hen's egg model. In conclusion, a long-term delivery system consisting of BNC and Poloxamer could be developed for octenidine as a ready-to-use system e.g. for long-term dermal wound treatment.
authors.affiliation: Department of Pharmaceutical Technology, Friedrich-Schiller-University Jena, Otto-Schott-Straße 41, 07745 Jena, Germany. Electronic address: yaser.alkhatib@uni-jena.de.
authors.forename: Y
authors.initials: Y
authors.lastname: Alkhatib
authors.affiliation: Department of Pharmaceutical Technology, Friedrich-Schiller-University Jena, Otto-Schott-Straße 41, 07745 Jena, Germany. Electronic address: marie.neumann@gmx.de.
authors.forename: M
authors.initials: M
authors.lastname: Dewaldt
authors.affiliation: Department of Pharmaceutical Technology, Friedrich-Schiller-University Jena, Otto-Schott-Straße 41, 07745 Jena, Germany. Electronic address: sebastian.moritz@uni-jena.de.
authors.forename: S
authors.initials: S
authors.lastname: Moritz
authors.affiliation: Malvern Instruments GmbH, Rigipsstraße 19, 71083 Herrenberg, Germany. Electronic address: rolf.nitzsche@malvern.com.
authors.forename: R
authors.initials: R
authors.lastname: Nitzsche
authors.affiliation: Department of Pharmaceutical Technology, Friedrich-Schiller-University Jena, Otto-Schott-Straße 41, 07745 Jena, Germany; Jena Center for Soft Matter (JCSM), Friedrich-Schiller-University Jena, Philosophenweg 7, 07743 Jena, Germany. Electronic address: dana.kralisch@uni-jena.de.
authors.forename: D
authors.initials: D
authors.lastname: Kralisch
authors.affiliation: Department of Pharmaceutical Technology, Friedrich-Schiller-University Jena, Otto-Schott-Straße 41, 07745 Jena, Germany; Jena Center for Soft Matter (JCSM), Friedrich-Schiller-University Jena, Philosophenweg 7, 07743 Jena, Germany. Electronic address: dagmar.fischer@uni-jena.de.
authors.forename: D
authors.initials: D
authors.lastname: Fischer
mesh_terms: D002482:Cellulose / Q000737:chemistry*; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D007097:Imines; D008826:Microbial Sensitivity Tests; D053758:Nanoparticles; D020442:Poloxamer / Q000737:chemistry*; D020560:Proteobacteria / Q000737:chemistry*; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D011725:Pyridines / Q000008:administration & dosage*; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D003692:Delayed-Action Preparations; D004337:Drug Carriers; D007097:Imines; D011725:Pyridines; D020442:Poloxamer; D002482:Cellulose; C034213:octenidine
keywords: Bacterial nanocellulose; Hydropolymer; Octenidine; Poloxamer; Wound dressing