title: Palladium(II)-Catalysed Aminocarbonylation of Terminal Alkynes for the Synthesis of 2-Ynamides: Addressing the Challenges of Solvents and Gas Mixtures.
abstract: 2-Ynamides can be synthesised through PdIIcatalysed oxidative carbonylation, utilising low catalyst loadings. A variety of alkynes and amines can be used to afford 2-ynamides in high yields, whilst overcoming the drawbacks associated with previous oxidative methods, which rely on dangerous solvents and gas mixtures. The use of [NBu4]I allows the utilisation of the industrially recommended solvent ethyl acetate. O2can be used as the terminal oxidant, and the catalyst can operate under safer conditions with low O2concentrations.
authors.affiliation: School of Chemistry and Chemical Engineering, Queen's University of Belfast, Stranmillis Road, Belfast, David Keir Building, BT9 5AG, Northern Ireland.
authors.forename: N Louise
authors.identifier: 0000-0001-5172-826X
authors.initials: NL
authors.lastname: Hughes
authors.affiliation: School of Chemistry and Chemical Engineering, Queen's University of Belfast, Stranmillis Road, Belfast, David Keir Building, BT9 5AG, Northern Ireland.
authors.forename: Clare L
authors.identifier: 0000-0001-8276-7501
authors.initials: CL
authors.lastname: Brown
authors.affiliation: School of Chemistry and Chemical Engineering, Queen's University of Belfast, Stranmillis Road, Belfast, David Keir Building, BT9 5AG, Northern Ireland.
authors.forename: Andrew A
authors.initials: AA
authors.lastname: Irwin
authors.affiliation: School of Chemistry and Chemical Engineering, Queen's University of Belfast, Stranmillis Road, Belfast, David Keir Building, BT9 5AG, Northern Ireland.
authors.forename: Qun
authors.identifier: 0000-0002-1726-7225
authors.initials: Q
authors.lastname: Cao
authors.affiliation: School of Chemistry and Chemical Engineering, Queen's University of Belfast, Stranmillis Road, Belfast, David Keir Building, BT9 5AG, Northern Ireland.
authors.forename: Mark J
authors.identifier: 0000-0002-9286-9672
authors.initials: MJ
authors.lastname: Muldoon
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D000577:Amides / Q000138:chemical synthesis*; D000588:Amines / Q000737:chemistry; D002384:Catalysis; D005740:Gases; D010084:Oxidation-Reduction; D010100:Oxygen / Q000737:chemistry; D010165:Palladium / Q000737:chemistry*; D012997:Solvents
chemical_list: D000480:Alkynes; D000577:Amides; D000588:Amines; D005740:Gases; D012997:Solvents; D010165:Palladium; D010100:Oxygen
keywords: alkynes; carbonylation; oxidation; palladium; solvents