title: Science Signaling Podcast for 29 November 2016: Pre-B cell receptor signaling in leukemia.
abstract: This Podcast features an interview with Bridget Wilson, author of a Research Article that appears in the 29 November 2016 issue of Science Signaling, about pre-B cell receptor (pre-BCR) signaling in B cell precursor acute lymphoblastic leukemia (BCP-ALL). Signaling through the pre-BCR, an immature form of the BCR, promotes the survival of B cell progenitors and has been implicated in the pathology of BCP-ALL. Erasmus et al found that pre-BCRs formed transient homomeric complexes that correlated with pro-survival signaling. Preventing homotypic interactions between pre-BCRs sensitized B cells to chemotherapeutic agents, suggesting that interfering with such interactions may improve the efficacy of existing chemotherapies for BCP-ALL.Listen to Podcast.
authors.affiliation: Department of Pathology and the UNM Comprehensive Cancer Center, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131, USA.
authors.forename: Bridget S
authors.initials: BS
authors.lastname: Wilson
authors.affiliation: Web Editor, Science Signaling, American Association for the Advancement of Science, 1200 New York Avenue, NW, Washington, DC 20005, USA.
authors.forename: Annalisa M
authors.initials: AM
authors.lastname: VanHook
mesh_terms: D000818:Animals; D006801:Humans; D009363:Neoplasm Proteins / Q000378:metabolism*; D054420:Pre-B Cell Receptors / Q000378:metabolism*; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000378:metabolism* / Q000473:pathology; D054448:Precursor Cells, B-Lymphoid / Q000378:metabolism* / Q000473:pathology; D015398:Signal Transduction
chemical_list: D009363:Neoplasm Proteins; D054420:Pre-B Cell Receptors