title: Ocimum gratissmumaqueous extract reduces plasma lipid in hypercholesterol-fed hamsters.
abstract: Objectives:Hyperlipidemia is a significant risk factor in the development of atherosclerosis and related diseases which are major health problem in many developed and developing countries that can lead to fatality due to the changes in lifestyle and dietary habits in this modern age.Methods:In the present study, theOcimum gratissimumaqueous extract (OGE) was tested for the lowering effect on the serum lipid level of male hamsters on a high-fat (12%) and high-cholesterol (0.2%) diet (HFCD).Results:The results showed that the levels of serum high-density-lipoprotein-cholesterol (HDL-C) low-density-lipoprotein-cholesterol (LDL-C), total cholesterol (TC), and triglycerols (TG) were increased in the HFCD group (113±11, 259±87, 629±175 and 625±262, respectively), as compared to the control normal diet group (51±8, 19±5, 77±16 and 101±44, respectively). When co-treated with various doses (10 and 20 mg/kg) of the OGE or rosuvastatin, the rats exhibited the restoration of normal serum LDL-C, TC, and TG levels.Conclusion:Therefore, we suggest that theOcimum gratissimumaqueous extract may have the potential function of lowering serum lipid in rats.
authors.affiliation: Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan.
authors.forename: Pei-Yu
authors.initials: PY
authors.lastname: Chao
authors.affiliation: Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan.
authors.forename: James A
authors.initials: JA
authors.lastname: Lin
authors.affiliation: Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan.
authors.forename: Wei-Jen
authors.initials: WJ
authors.lastname: Ting
authors.affiliation: Department of Laboratory Medicine, Kuang Tien General Hospital, Taichung, Taiwan.
authors.forename: Hsueh-Hui
authors.initials: HH
authors.lastname: Lee
authors.affiliation: Department of Laboratory Medicine, Kuang Tien General Hospital, Taichung, Taiwan.
authors.forename: Kuanghui
authors.initials: K
authors.lastname: Hsieh
authors.affiliation: Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.; Emergency department and center of Hyperbaric Oxygen Therapy, Tungs' Taichung MetroHarbor Hospital, Taichung Taiwan.
authors.forename: Yung-Wei
authors.initials: YW
authors.lastname: Chiu
authors.affiliation: Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.; Department of Psychiatry, Chung Shan Medical Hospital, Taichung, Taiwan.
authors.forename: Te-Jen
authors.initials: TJ
authors.lastname: Lai
authors.affiliation: Department of Applied Chemistry, College of Health Care and Management, Chung Shan Medical University, Taichung, Taiwan.
authors.forename: Jin-Ming
authors.initials: JM
authors.lastname: Hwang
authors.affiliation: Graduate Institute of Cancer Biology, China Medical University, Taichung, Taiwan; Center for Molecular Medicine, China Medical University Hospital, Taichung, Taiwan.
authors.forename: Je-rYuh
authors.initials: JR
authors.lastname: Liu
authors.affiliation: Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan; Graduate Institute of Chinese Medical Science, School of Chinese Medicine, China Medical University, Taichung, Taiwan; Department of Health and Nutrition Biotechnology, Asia University, Taichung, Taiwan.
authors.forename: Chih-Yang
authors.initials: CY
authors.lastname: Huang
mesh_terms: D000818:Animals; D000924:Anticholesteremic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D008076:Cholesterol, HDL / Q000097:blood / Q000187:drug effects*; D008078:Cholesterol, LDL / Q000097:blood / Q000187:drug effects*; D006224:Cricetinae; D059305:Diet, High-Fat / Q000009:adverse effects; D004195:Disease Models, Animal; D006949:Hyperlipidemias / Q000097:blood / Q000188:drug therapy*; D008099:Liver / Q000473:pathology; D008297:Male; D008647:Mesocricetus; D031339:Ocimum / Q000737:chemistry*; D010936:Plant Extracts / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D000068718:Rosuvastatin Calcium / Q000008:administration & dosage / Q000627:therapeutic use; D014280:Triglycerides / Q000097:blood*; D014867:Water
chemical_list: D000924:Anticholesteremic Agents; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D010936:Plant Extracts; D014280:Triglycerides; D014867:Water; D000068718:Rosuvastatin Calcium
keywords: Hyperlipidemia; Ocimum gratissimum; cholesterol