title: Coagulopathy of Trauma.
abstract: Coagulopathy is common after injury and develops independently from iatrogenic, hypothermic, and dilutional causes. Despite considerable research on the topic over the past decade, trauma-induced coagulopathy (TIC) continues to portend poor outcomes, including decreased survival. We review the current evidence regarding the diagnosis and mechanisms underlying trauma induced coagulopathy and summarize the debates regarding optimal management strategy including product resuscitation, potential pharmacologic adjuncts, and targeted approaches to hemostasis. Throughout, we will identify areas of continued investigation and controversy in the understanding and management of TIC.
authors.affiliation: Department of Surgery, San Francisco General Hospital, University of California, San Francisco, School of Medicine, 1001 Potrero Avenue, San Francisco, CA 94110, USA. Electronic address: Mitchell.Cohen@ucsf.edu.
authors.forename: Mitchell J
authors.initials: MJ
authors.lastname: Cohen
authors.affiliation: Department of Surgery, San Francisco General Hospital, University of California, San Francisco, School of Medicine, 1001 Potrero Avenue, San Francisco, CA 94110, USA.
authors.forename: S Ariane
authors.initials: SA
authors.lastname: Christie
mesh_terms: D001778:Blood Coagulation Disorders / Q000209:etiology* / Q000628:therapy*; D006470:Hemorrhage / Q000209:etiology* / Q000628:therapy*; D006801:Humans; D014947:Wounds and Injuries / Q000150:complications* / Q000175:diagnosis / Q000628:therapy*
keywords: Bleeding; Coagulation; Coagulopathy; Hemorrhage; Targeted resuscitation; Trauma; Trauma-induced coagulopathy