title: On-chip integration of organic synthesis and HPLC/MS analysis for monitoring stereoselective transformations at the micro-scale.
abstract: We present a microfluidic system, seamlessly integrating microflow and microbatch synthesis with a HPLC/nano-ESI-MS functionality on a single glass chip. The microfluidic approach allows to efficiently steer and dispense sample streams down to the nanoliter-range for studying reactions in quasi real-time. In a proof-of-concept study, the system was applied to explore amino-catalyzed reactions, including asymmetric iminium-catalyzed Friedel-Crafts alkylations in microflow and micro confined reaction vessels.
authors.affiliation: Institute of Analytical Chemistry, University of Leipzig, Linnéstr. 3, D-04103 Leipzig, Germany. belder@uni-leipzig.de.
authors.forename: Josef J
authors.initials: JJ
authors.lastname: Heiland
authors.affiliation: Institute of Analytical Chemistry, University of Leipzig, Linnéstr. 3, D-04103 Leipzig, Germany. belder@uni-leipzig.de.
authors.forename: Rico
authors.initials: R
authors.lastname: Warias
authors.affiliation: Institute of Analytical Chemistry, University of Leipzig, Linnéstr. 3, D-04103 Leipzig, Germany. belder@uni-leipzig.de.
authors.forename: Carsten
authors.initials: C
authors.lastname: Lotter
authors.affiliation: Institute of Analytical Chemistry, University of Leipzig, Linnéstr. 3, D-04103 Leipzig, Germany. belder@uni-leipzig.de.
authors.forename: Laura
authors.initials: L
authors.lastname: Mauritz
authors.affiliation: Institute of Organic Chemistry, University of Leipzig, Johannisallee. 29, D-04103 Leipzig, Germany.
authors.forename: Patrick J W
authors.initials: PJ
authors.lastname: Fuchs
authors.affiliation: Institute of Analytical Chemistry, University of Leipzig, Linnéstr. 3, D-04103 Leipzig, Germany. belder@uni-leipzig.de.
authors.forename: Stefan
authors.initials: S
authors.lastname: Ohla
authors.affiliation: Institute of Organic Chemistry, University of Leipzig, Johannisallee. 29, D-04103 Leipzig, Germany.
authors.forename: Kirsten
authors.identifier: 0000-0003-1549-5002
authors.initials: K
authors.lastname: Zeitler
authors.affiliation: Institute of Analytical Chemistry, University of Leipzig, Linnéstr. 3, D-04103 Leipzig, Germany. belder@uni-leipzig.de.
authors.forename: Detlev
authors.initials: D
authors.lastname: Belder