title: Synthesis of nanoparticle CT contrast agents:in vitroandin vivostudies.
abstract: Water-soluble and biocompatible D-glucuronic acid coated Na2WO4and BaCO3nanoparticles were synthesized for the first time to be used as x-ray computed tomography (CT) contrast agents. Their average particle diameters were 3.2 ± 0.1 and 2.8 ± 0.1 nm for D-glucuronic acid coated Na2WO4and BaCO3nanoparticles, respectively. All the nanoparticles exhibited a strong x-ray attenuation.In vivoCT images were obtained after intravenous injection of an aqueous sample suspension of D-glucuronic acid coated Na2WO4nanoparticles, and positive contrast enhancements in the kidney were clearly shown. These findings indicate that the nanoparticles reported in this study may be promising CT contrast agents.
authors.affiliation: Department of Chemistry, College of Natural Sciences, Kyungpook National University (KNU), Taegu 702-701, Korea.
authors.forename: Sung June
authors.initials: SJ
authors.lastname: Kim
authors.affiliation: Department of Chemistry, College of Natural Sciences, Kyungpook National University (KNU), Taegu 702-701, Korea.
authors.forename: Wenlong
authors.initials: W
authors.lastname: Xu
authors.affiliation: Department of Chemistry, College of Natural Sciences, Kyungpook National University (KNU), Taegu 702-701, Korea.
authors.forename: Md Wasi
authors.initials: MW
authors.lastname: Ahmad
authors.affiliation: Department of Molecular Medicine and Medical & Biological Engineering, School of Medicine, KNU and Hospital, Taegu 702-701, Korea.
authors.forename: Jong Su
authors.initials: JS
authors.lastname: Baeck
authors.affiliation: Department of Molecular Medicine and Medical & Biological Engineering, School of Medicine, KNU and Hospital, Taegu 702-701, Korea; Department of Nanoscience and Nanotechnology, KNU, Taegu 702-701, Korea.
authors.forename: Yongmin
authors.initials: Y
authors.lastname: Chang
authors.affiliation: Department of Nanoscience and Nanotechnology, KNU, Taegu 702-701, Korea.
authors.forename: Ji Eun
authors.initials: JE
authors.lastname: Bae
authors.affiliation: Department of Nanoscience and Nanotechnology, KNU, Taegu 702-701, Korea; Department of Biology Education, Teacher's College, KNU, Taegu 702-701, Korea.
authors.forename: Kwon Seok
authors.initials: KS
authors.lastname: Chae
authors.affiliation: Institute of Biomedical Engineering Research, KNU, Taegu 702-701, Korea.
authors.forename: Tae Jeong
authors.initials: TJ
authors.lastname: Kim
authors.affiliation: Laboratory of Nuclear Medicine Research, Molecular Imaging Research Center, Korea Institute of Radiological Medical Science, Nowon-gil 75, Seoul 139-706, Korea.
authors.forename: Ji Ae
authors.initials: JA
authors.lastname: Park
authors.affiliation: Department of Chemistry, College of Natural Sciences, Kyungpook National University (KNU), Taegu 702-701, Korea; Department of Nanoscience and Nanotechnology, KNU, Taegu 702-701, Korea.
authors.forename: Gang Ho
authors.initials: GH
authors.lastname: Lee
keywords: BaCO3; CT contrast agent; Na2WO4; nanoparticle