title: Regulation of Platelet Activation and Coagulation and Its Role in Vascular Injury and Arterial Thrombosis.
abstract: Hemostasis requires tightly regulated interaction of the coagulation system, platelets, blood cells, and vessel wall components at a site of vascular injury. Dysregulation of this response may result in excessive bleeding if the response is impaired, and pathologic thrombosis with vessel occlusion and tissue ischemia if the response is robust. Studies have elucidated the major molecular signaling pathways responsible for platelet activation and aggregation. Antithrombotic agents targeting these pathways are in clinical use. This review summarizes research examining mechanisms by which these multiple platelet signaling pathways are integrated at a site of vascular injury to produce an optimal hemostatic response.
authors.affiliation: Department of Medicine, Perelman School of Medicine, University of Pennsylvania, 421 Curie Boulevard, Philadelphia, PA, 19104, USA.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Tomaiuolo
authors.affiliation: Department of Medicine, Perelman School of Medicine, University of Pennsylvania, 421 Curie Boulevard, Philadelphia, PA, 19104, USA.
authors.forename: Lawrence F
authors.initials: LF
authors.lastname: Brass
authors.affiliation: Department of Medicine, Perelman School of Medicine, University of Pennsylvania, 421 Curie Boulevard, Philadelphia, PA, 19104, USA. Electronic address: tstalker@mail.med.upenn.edu.
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Stalker
mesh_terms: D000818:Animals; D001777:Blood Coagulation / Q000502:physiology*; D001792:Blood Platelets; D006801:Humans; D015539:Platelet Activation / Q000502:physiology*; D010974:Platelet Aggregation; D013927:Thrombosis / Q000097:blood* / Q000209:etiology; D057772:Vascular System Injuries / Q000097:blood* / Q000150:complications
keywords: Antithrombotic agents; Arterial thrombosis; Coagulation; Hemostasis; Platelet activation; Vascular injury