title: The pattern-recognition receptor CORE of Solanaceae detects bacterial cold-shock protein.
abstract: Plants and animals recognize microbial invaders by detecting microbe-associated molecular patterns (MAMPs) by cell surface receptors. Many plant species of the Solanaceae family detect the highly conserved nucleic acid binding motif RNP-1 of bacterial cold-shock proteins (CSPs), represented by the peptide csp22, as a MAMP. Here, we exploited the natural variation in csp22 perception observed between cultivated tomato (Solanum lycopersicum) and Solanum pennellii to map and identify the leucine-rich repeat (LRR) receptor kinase CORE (cold shock protein receptor) of tomato as the specific, high-affinity receptor site for csp22. Corroborating its function as a genuine receptor, heterologous expression of CORE in Arabidopsis thaliana conferred full sensitivity to csp22 and, importantly, it also rendered these plants more resistant to infection by the bacterial pathogen Pseudomonas syringae pv. tomato DC3000. Our study also confirms the biotechnological potential of enhancing plant immunity by interspecies transfer of highly effective pattern-recognition receptors such as CORE to different plant families.
authors.affiliation: ZMBP, University of Tübingen, Auf der Morgenstelle 32, D-72076 Tübingen, Germany.
authors.forename: Lei
authors.identifier: 0000-0002-6332-6476
authors.initials: L
authors.lastname: Wang
authors.affiliation: ZMBP, University of Tübingen, Auf der Morgenstelle 32, D-72076 Tübingen, Germany.
authors.forename: Markus
authors.initials: M
authors.lastname: Albert
authors.affiliation: ZMBP, University of Tübingen, Auf der Morgenstelle 32, D-72076 Tübingen, Germany.
authors.forename: Elias
authors.initials: E
authors.lastname: Einig
authors.affiliation: ZMBP, University of Tübingen, Auf der Morgenstelle 32, D-72076 Tübingen, Germany.
authors.forename: Ursula
authors.initials: U
authors.lastname: Fürst
authors.affiliation: ZMBP, University of Tübingen, Auf der Morgenstelle 32, D-72076 Tübingen, Germany.
authors.forename: Damaris
authors.initials: D
authors.lastname: Krust
authors.affiliation: ZMBP, University of Tübingen, Auf der Morgenstelle 32, D-72076 Tübingen, Germany.
authors.forename: Georg
authors.identifier: 0000-0002-6746-6185
authors.initials: G
authors.lastname: Felix
mesh_terms: D017360:Arabidopsis / Q000235:genetics / Q000276:immunology*; D001426:Bacterial Proteins / Q000502:physiology; D057773:Cold Shock Proteins and Peptides / Q000502:physiology; D018551:Solanum lycopersicum / Q000235:genetics* / Q000378:metabolism; D010940:Plant Proteins / Q000235:genetics* / Q000378:metabolism; D030821:Plants, Genetically Modified / Q000235:genetics / Q000276:immunology; D044224:Pseudomonas syringae / Q000502:physiology*; D051192:Receptors, Pattern Recognition / Q000235:genetics* / Q000378:metabolism; D032322:Solanum / Q000235:genetics* / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; D057773:Cold Shock Proteins and Peptides; D010940:Plant Proteins; D051192:Receptors, Pattern Recognition