title: Ag/N-doped reduced graphene oxide incorporated with molecularly imprinted polymer: An advanced electrochemical sensing platform for salbutamol determination.
abstract: In this work, the metallic silver and non-metallic nitrogen co-doped reduced graphene oxide (Ag-N-RGO) was first synthesized by a simple and cost-effective strategy, and then a molecularly imprinted polymer (MIP) was formed in situ at the surface of the prepared composite via electropolymerization of o-phenylenediamine in the presence of salbutamol as the template molecule. The electrochemical characterizations demonstrate that the bifunctional graphene-based composite shows improved catalytic performance than that of pristine graphene doped with one-component or none. The MIP sensor based on Ag-N-RGO owns high porous surface structure, resulting in the increased current response and enhanced recognition capacity than that of non-imprinted sensor. The outstanding performance of the developed sensor derives from the combined advantages of Ag-N-RGO with effective catalytic property and MIP with excellent selectivity. Under the optimal conditions, the electrochemical response of the developed sensor is linearly proportional to the concentration of salbutamol in the range of 0.03-20.00µmolL-1with a low detection limit of 7 nmol L-1. The designed sensor has exhibited the multiple advantages such as low cost, simple manufacture, convenient use, excellent selectivity and good reproducibility. Finally, the proposed method has been extended for the determinations of salbutamol in human urine and pork samples, and the satisfactory recoveries between 98.9-105.3% are achieved.
authors.affiliation: College of Chemistry and Material Science, Hengyang Normal University, Hengyang 421008, PR China; College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, PR China; Key Laboratory of Functional Organometallic Materials, Hengyang Normal University, Hengyang 421008, PR China.
authors.forename: Junhua
authors.initials: J
authors.lastname: Li
authors.affiliation: College of Chemistry and Material Science, Hengyang Normal University, Hengyang 421008, PR China.
authors.forename: Zhifeng
authors.initials: Z
authors.lastname: Xu
authors.affiliation: College of Chemistry and Material Science, Hengyang Normal University, Hengyang 421008, PR China.
authors.forename: Mengqin
authors.initials: M
authors.lastname: Liu
authors.affiliation: College of Chemistry and Material Science, Hengyang Normal University, Hengyang 421008, PR China.
authors.forename: Peihong
authors.initials: P
authors.lastname: Deng
authors.affiliation: College of Chemistry and Material Science, Hengyang Normal University, Hengyang 421008, PR China.
authors.forename: Siping
authors.initials: S
authors.lastname: Tang
authors.affiliation: College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, PR China.
authors.forename: Jianbo
authors.initials: J
authors.lastname: Jiang
authors.affiliation: College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, PR China.
authors.forename: Haibo
authors.initials: H
authors.lastname: Feng
authors.affiliation: College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, PR China. Electronic address: qiandong6@vip.sina.com.
authors.forename: Dong
authors.initials: D
authors.lastname: Qian
authors.affiliation: College of Chemistry and Material Science, Hengyang Normal University, Hengyang 421008, PR China; School of Medicine, Hunan Polytechnic of Environment and Biology, Hengyang 421008, PR China. Electronic address: 42460288@qq.com.
authors.forename: Lingzhi
authors.initials: L
authors.lastname: He
mesh_terms: D058666:Adrenergic beta-2 Receptor Agonists / Q000032:analysis* / Q000652:urine*; D000420:Albuterol / Q000032:analysis* / Q000652:urine*; D000818:Animals; D015374:Biosensing Techniques / Q000379:methods; D002384:Catalysis; D055664:Electrochemical Techniques / Q000379:methods*; D006108:Graphite / Q000737:chemistry*; D006801:Humans; D057230:Limit of Detection; D054802:Molecular Imprinting / Q000379:methods; D010084:Oxidation-Reduction; D010087:Oxides / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D000069466:Red Meat / Q000032:analysis*; D012834:Silver / Q000737:chemistry; D013552:Swine
chemical_list: D058666:Adrenergic beta-2 Receptor Agonists; D010087:Oxides; D011108:Polymers; D012834:Silver; D006108:Graphite; D000420:Albuterol
keywords: Ag/N-doped reduced graphene oxide; Electrochemical sensor; Molecularly imprinted polymer; Salbutamol