title: Comparison of Therapeutic Efficacy of Placental Extract with Dexamethasone and Hyaluronic Acid with Dexamethasone for Oral Submucous Fibrosis - A Retrospective Analysis.
abstract: BACKGROUND
  Oral Submucous Fibrosis (OSMF) is a potentially malignant disease of the oral cavity associated with betel nut chewing. The management of OSMF has been a subject of controversy and no definitive and widely accepted treatment is currently available for this condition.
  
  
  OBJECTIVE
  To retrospectively evaluate the therapeutic efficacy of two treatment regimens (placental extract with dexamethasone and hyaluronic acid with dexamethasone) for the treatment of OSMF.
  
  
  METHODS
  The records of the patients diagnosed with OSMF were obtained from the departmental archives. A total of 25 records were selected and divided into two study groups based on the treatment regimens, as Group A (placental extract + dexamethasone) and Group B (hyaluronidase + dexamethasone). The records were studied for improvement in mouth opening and reduction in burning sensation. Descriptive statistics, paired t test and student's t test were used for statistical analysis.
  
  
  RESULTS
  In Group A and Group B, the average increase in mouth opening from baseline record to 8th week of treatment was 3.53±1.26mm and 3.65±1.42mm respectively and average decrease in burning sensation, noted by VAS scale, was 5.13±1.13 and 4.90 ±1.29 respectively. The pre- and post-treatment differences were found to be statistically significant for both the groups (p<0.001) and for both the treatment outcomes. When the average difference of the treatment outcomes was compared between the two study groups, no statistically significant difference was noted (p>0.05).
  
  
  CONCLUSIONS
  The results of the present study indicate that both the treatment regimens studied are equally effective in the treatment of oral submucous fibrosis.
authors.affiliation: Postgraduate Student, Department of Oral Medicine and Radiology, K. M. Shah Dental College and Hospital, Sumandeep Vidyapeeth , Vadodara, Gujarat, India .
authors.forename: Palak Hasmukhbhai
authors.initials: PH
authors.lastname: Shah
authors.affiliation: Reader, Department of Oral Medicine and Radiology, K. M. Shah Dental College and Hospital, Sumandeep Vidyapeeth , Vadodara, Gujarat, India .
authors.forename: Rashmi
authors.initials: R
authors.lastname: Venkatesh
authors.affiliation: Professor and Head, Department of Oral Medicine and Radiology, K. M. Shah Dental College and Hospital, Sumandeep Vidyapeeth , Vadodara, Gujarat, India .
authors.forename: Chandramani Bhagawan
authors.initials: CB
authors.lastname: More
authors.affiliation: Reader, Department of Oral Medicine and Radiology, K. M. Shah Dental College and Hospital, Sumandeep Vidyapeeth , Vadodara, Gujarat, India .
authors.forename: Vaishnavee
authors.initials: V
authors.lastname: Vassandacoumara
keywords: Areca nut; Burning sensation; Intralesional injections; Mouth opening