title: A DNA nanoswitch-controlled reversible nanosensor.
abstract: We present a conceptually new reversible nanosensor regulated by a DNA nanoswitch. This system is not only responsive to external stimuli (e.g. ATP) but also can be reversibly switched between 'OFF' and 'ON' states via toehold mediated strand displacement reactions. It functions like a molecular net woven by DNA to capture or release the target molecules. As a proof-of-principle experiment, ATP is here chosen as the model to demonstrate our new strategy, which holds great promise for applications such as switchable DNA nanomachines and nanocarriers for drug delivery.
authors.affiliation: Department of Chemistry, University of Science and Technology of China, 96 Jinzhai Road, Hefei, Anhui 230026, China.
authors.forename: Pai
authors.identifier: 0000-0002-9655-1047
authors.initials: P
authors.lastname: Peng
authors.affiliation: Department of Chemistry, University of Science and Technology of China, 96 Jinzhai Road, Hefei, Anhui 230026, China.
authors.forename: Lili
authors.initials: L
authors.lastname: Shi
authors.affiliation: Department of Chemistry, University of Science and Technology of China, 96 Jinzhai Road, Hefei, Anhui 230026, China.
authors.forename: Huihui
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Chemistry, University of Science and Technology of China, 96 Jinzhai Road, Hefei, Anhui 230026, China tlitao@ustc.edu.cn.
authors.forename: Tao
authors.initials: T
authors.lastname: Li
mesh_terms: D000255:Adenosine Triphosphate / Q000737:chemistry; D015374:Biosensing Techniques; D004247:DNA / Q000032:analysis* / Q000737:chemistry*; D036103:Nanotechnology; D009690:Nucleic Acid Conformation; D013050:Spectrometry, Fluorescence
chemical_list: D000255:Adenosine Triphosphate; D004247:DNA