title: Design, synthesis and cytotoxicity studies of novel pyrazolo[1, 5-a]pyridine derivatives.
abstract: Copper-mediated synthesis of various pyrazolo[1, 5-a]pyridine-3-carboxylates has been described. The biological activities of these molecules have been evaluated against various human cancer cell lines A549 (Lung adenocarcinoma cell line), MCF-7 (Breast carcinoma cell line), HCT-116 (Colon cancer cell line), and PC-3 (Prostate cancer cell line) through SRB assay. Compound 247 led to accumulation MCF-7 cells in G1-phase and revealed its important role in mitotic cell cycle progression.
authors.affiliation: Academy of Scientific & Innovative Research, Natural Products and Green Chemistry Division, CSIR-Central Salt & Marine Chemicals Research Institute, G.B. Marg, Bhavnagar, 364 002, Gujarat, India.
authors.forename: Chitrakar
authors.initials: C
authors.lastname: Ravi
authors.affiliation: CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu, 180001, India.
authors.forename: Arem
authors.initials: A
authors.lastname: Qayum
authors.affiliation: Academy of Scientific & Innovative Research, Natural Products and Green Chemistry Division, CSIR-Central Salt & Marine Chemicals Research Institute, G.B. Marg, Bhavnagar, 364 002, Gujarat, India.
authors.forename: Darapaneni
authors.initials: D
authors.lastname: Chandra Mohan
authors.affiliation: CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu, 180001, India. Electronic address: sksingh@iiim.ac.in.
authors.forename: Shashank K
authors.initials: SK
authors.lastname: Singh
authors.affiliation: Academy of Scientific & Innovative Research, Natural Products and Green Chemistry Division, CSIR-Central Salt & Marine Chemicals Research Institute, G.B. Marg, Bhavnagar, 364 002, Gujarat, India. Electronic address: adimurthy@csmcri.org.
authors.forename: Subbarayappa
authors.initials: S
authors.lastname: Adimurthy
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D060326:Chemistry Techniques, Synthetic; D004305:Dose-Response Relationship, Drug; D015195:Drug Design; D006801:Humans; D011720:Pyrazoles / Q000737:chemistry*; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D011720:Pyrazoles; D011725:Pyridines
keywords: Cytotoxicity; Growth inhibition; MCF-7 cells; Pyrazolo[1, 5–a]pyridines; SRB assay