title: Pemphigus herpetiformis-type drug reaction caused by erdosteine containing mucolytic in a child.
abstract: Drug-related pemphigus is very rare in children. Erdosteine is a thiol compound having mucoactive, antioxidant, anti-inflammatory, and antitussive effects and is reported to be safe for treatment of acute respiratory tract diseases in children. Herein, we report a 9-year-old boy presented with pemphigus herpetiformis associated with anti-desmoglein 1 antibodies due to erdosteine consumption.
authors.affiliation: a Department of Dermatovenereology , Ankara Ataturk Training and Research Hospital , Ankara , Turkey and.
authors.forename: Gulsen
authors.initials: G
authors.lastname: Akoglu
authors.affiliation: b Department of Pathology , Ankara Ataturk Training and Research Hospital , Ankara , Turkey.
authors.forename: Sibel Orhun
authors.initials: SO
authors.lastname: Yavuz
mesh_terms: D002648:Child; D051183:Desmoglein 1 / Q000276:immunology; D003875:Drug Eruptions / Q000097:blood / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D005100:Expectorants / Q000009:adverse effects*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D010392:Pemphigus / Q000097:blood / Q000139:chemically induced* / Q000276:immunology / Q000473:pathology; D012867:Skin / Q000473:pathology; D013864:Thioglycolates / Q000009:adverse effects*; D013876:Thiophenes / Q000009:adverse effects*
chemical_list: C495297:DSG1 protein, human; D051183:Desmoglein 1; D005100:Expectorants; D007074:Immunoglobulin G; D013864:Thioglycolates; D013876:Thiophenes; C048498:erdosteine
keywords: Autoimmune bullous disease; cutaneous side effect; thiol drug