title: Comparison of xenobiotic-metabolising human, porcine, rodent, and piscine cytochrome P450.
abstract: Cytochrome P450 proteins (CYP450s) are present in most domains of life and play a critical role in the metabolism of endogenous compounds and xenobiotics. The effects of exposure to xenobiotics depend heavily on the expression and activity of drug-metabolizing CYP450s, which is determined by species, genetic background, age, gender, diet, and exposure to environmental pollutants. Numerous reports have investigated the role of different vertebrate CYP450s in xenobiotic metabolism. Model organisms provide powerful experimental tools to investigate Phase I metabolism. The aim of the present review is to compare the existing data on human CYP450 proteins (1-3 families) with those found in pigs, mice, and fish. We will highlight differences and similarities and identify research gaps which need to be addressed in order to use these species as models that mimic human traits. Moreover, we will discuss the roles of nuclear receptors in the cellular regulation of CYP450 expression in select organisms.
authors.affiliation: University of South Bohemia in Ceske Budejovice, Faculty of Fisheries and Protection of Waters, South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, Zatisi 728/II, 389 25 Vodnany, Czechia. Electronic address: vburkina@frov.jcu.cz.
authors.forename: Viktoriia
authors.initials: V
authors.lastname: Burkina
authors.affiliation: Department of Food Science, Aarhus University, P.O. Box 50, DK-8830 Tjele, Denmark. Electronic address: Martink.rasmussen@food.au.dk.
authors.forename: Martin Krøyer
authors.initials: MK
authors.lastname: Rasmussen
authors.affiliation: Department of Food Science, Swedish University of Agricultural Sciences, Uppsala BioCenter, P.O. Box 7051, SE-750 07 Uppsala, Sweden. Electronic address: nadezhola.pilipenko@slu.se.
authors.forename: Nadezhda
authors.initials: N
authors.lastname: Pilipenko
authors.affiliation: University of South Bohemia in Ceske Budejovice, Faculty of Fisheries and Protection of Waters, South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, Zatisi 728/II, 389 25 Vodnany, Czechia; Department of Food Science, Swedish University of Agricultural Sciences, Uppsala BioCenter, P.O. Box 7051, SE-750 07 Uppsala, Sweden. Electronic address: Galia.Zamaratskaia@slu.se.
authors.forename: Galia
authors.initials: G
authors.lastname: Zamaratskaia
mesh_terms: D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics* / Q000378:metabolism*; D005399:Fishes; D006801:Humans; D051379:Mice; D013045:Species Specificity; D013552:Swine; D015262:Xenobiotics / Q000378:metabolism* / Q000633:toxicity
chemical_list: D015262:Xenobiotics; D003577:Cytochrome P-450 Enzyme System
keywords: Comparison; Detoxification; Drug; Model organism; Pollution