title: Is it relevant to screen young women hospitalized in psychiatric department for neuropsychiatric systemic lupus erythematosus (NPSLE)?: A prospective study of 100 psychiatric inpatients.
abstract: On the basis that diagnosis of neuropsychiatric systemic lupus erythematosus (NPSLE) is sometimes difficult and systemic lupus erythematosus (SLE) can present with isolated psychiatric symptoms, we initiated a survey in a psychiatric department to screen for NPSLE in young female inpatients.We prospectively studied consecutive young female patients referred to the department of psychiatry. Antinuclear antibodies (ANA), anti-deoxyribonucleic acid (DNA), and antiextractable soluble nuclear antigens (ENA) in the serum of patients were screened. In case of positive anti-DNA or anti-ENA, the patient was referred to the department of internal medicine.One hundred patients were enrolled, mean age 33.1 ± 8.4 years. Most patients presented underlying psychiatric disorders: depression (46%), schizophrenia (13%), anxiety disorder (6%), and personality disorder (10%). A quarter of the cohort did not display underlying psychiatric disorders before hospitalization. Positive ANA ≥1:160 were found in 32 of the 100 patients tested (32%). No patients presented anti-DNA antibodies. One patient had positive anti-sjogrën's syndrome related antigen A (SSA), but did not present any features of SLE or Sjögren syndrome.Thus, systematic screening of SLE is not relevant in young women hospitalized in psychiatric department. However, clinicians should keep in mind that SLE can present with pure psychiatric symptoms.
authors.affiliation: Departement of internal medicine, CHU de Caen, France Caen University, Caen, France Immunology departement, Caen , France Department of Psychiatry, CHU de Caen, Caen Department of Immunology, Institut Cochin, Paris, France.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Audemard-Verger
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Comby
authors.forename: Clément
authors.initials: C
authors.lastname: Nathou
authors.forename: Audrey
authors.initials: A
authors.lastname: Sultan
authors.forename: Mathieu
authors.initials: M
authors.lastname: Frémont
authors.forename: Aurélie
authors.initials: A
authors.lastname: Baldolli
authors.forename: Louis Simon
authors.initials: LS
authors.lastname: Trumier
authors.forename: Vincent
authors.initials: V
authors.lastname: Marzloff
authors.forename: Brigitte
authors.initials: B
authors.lastname: Le Mauff
authors.forename: Jennifer
authors.initials: J
authors.lastname: Manuzak
authors.forename: Sonia
authors.initials: S
authors.lastname: Dollfus
authors.forename: Boris
authors.initials: B
authors.lastname: Bienvenu
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D005602:France; D006801:Humans; D007297:Inpatients / Q000523:psychology*; D020945:Lupus Vasculitis, Central Nervous System / Q000175:diagnosis*; D008403:Mass Screening; D008875:Middle Aged; D011446:Prospective Studies; D011567:Psychiatric Department, Hospital