title: Evaluation of maternal and perinatal characteristics on childhood lymphoma risk: A population-based case-control study.
abstract: Lymphoma is one of the most common pediatric malignancies; however, there are few well-established risk factors. Therefore, we investigated if maternal and perinatal characteristics influenced the risk of childhood lymphoma.
  
  
  
  Information on cases (n = 374) diagnosed with lymphoma and born in Texas for the period 1995-2011 was obtained from the Texas Cancer Registry. Birth certificate controls were randomly selected at a ratio of 10 controls per 1 case for the same period of 1995-2011. Unconditional logistic regression was used to generate unadjusted (OR) and adjusted odds ratios (aOR) and 95% confidence intervals (CI) for the following histologic subtypes: Hodgkin (HL), Burkitt (BL), and non-BL non-HLs (non-BL NHLs).
  
  
  
  Overall, our findings indicate specific maternal and perinatal characteristics influence childhood lymphoma risk. Mexico-born mothers were more likely to have offspring who developed BL compared to mothers born in the United States (U.S.; aOR: 2.15; 95% CI: 1.06-4.36). Further, mothers who resided at time of delivery in a county on the U.S.-Mexico border were more likely to give birth to offspring who developed non-BL NHL (aOR: 1.72; 95% CI: 1.11-2.67) compared to mothers not living on the U.S.-Mexico border at time of infant birth. Last, infants born large-for-gestational-age experienced a twofold increase in BL risk (aOR: 2.00; 95% CI: 1.10-3.65).
  
  
  
  In this population-based assessment, we confirmed previously reported risk predictors of childhood lymphoma, including sex of infant, while highlighting novel risk factors that warrant assessment in future studies.
authors.affiliation: Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, Houston, Texas.|Texas Children's Cancer Center, Texas Children's Hospital, Houston, Texas.
authors.forename: Erin C
authors.initials: EC
authors.lastname: Peckham-Gregory
authors.affiliation: Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, Houston, Texas.|Texas Children's Cancer Center, Texas Children's Hospital, Houston, Texas.
authors.forename: Heather E
authors.initials: HE
authors.lastname: Danysh
authors.affiliation: Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, Houston, Texas.|Texas Children's Cancer Center, Texas Children's Hospital, Houston, Texas.
authors.forename: Austin L
authors.initials: AL
authors.lastname: Brown
authors.affiliation: Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, Houston, Texas.|Texas Children's Cancer Center, Texas Children's Hospital, Houston, Texas.
authors.forename: Olive
authors.initials: O
authors.lastname: Eckstein
authors.affiliation: Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, Houston, Texas.|Texas Children's Cancer Center, Texas Children's Hospital, Houston, Texas.
authors.forename: Amanda
authors.initials: A
authors.lastname: Grimes
authors.affiliation: Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, Houston, Texas.|Texas Children's Cancer Center, Texas Children's Hospital, Houston, Texas.
authors.forename: Rikhia
authors.initials: R
authors.lastname: Chakraborty
authors.affiliation: Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, Houston, Texas.|Texas Children's Cancer Center, Texas Children's Hospital, Houston, Texas.
authors.forename: Joseph
authors.initials: J
authors.lastname: Lubega
authors.affiliation: Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, Houston, Texas.|Texas Children's Cancer Center, Texas Children's Hospital, Houston, Texas.
authors.forename: Kenneth L
authors.initials: KL
authors.lastname: McClain
authors.affiliation: Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, Houston, Texas.|Texas Children's Cancer Center, Texas Children's Hospital, Houston, Texas.|Program in Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, Texas.
authors.forename: Carl E
authors.initials: CE
authors.lastname: Allen
authors.affiliation: Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, Houston, Texas.|Texas Children's Cancer Center, Texas Children's Hospital, Houston, Texas.
authors.forename: Michael E
authors.initials: ME
authors.lastname: Scheurer
authors.affiliation: Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, Houston, Texas.|Texas Children's Cancer Center, Texas Children's Hospital, Houston, Texas.
authors.forename: Philip J
authors.initials: PJ
authors.lastname: Lupo
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D006689:Hodgkin Disease / Q000453:epidemiology*; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000453:epidemiology*; D008297:Male; D008800:Mexico / Q000453:epidemiology; D012307:Risk Factors; D013781:Texas / Q000453:epidemiology; D014481:United States / Q000453:epidemiology
keywords: Texas Cancer Registry; childhood; epidemiology; lymphoma; perinatal; risk factors