title: Photoswitchable and Water-Soluble Fluorescent Nano-Aggregates Based on a Diarylethene-Dansyl Dyad and Liposome.
abstract: In this work, a unique approach is developed to generate photoswitchable and water-soluble fluorescent nano-aggregates. Initially, a new light-controlled diarylethene-dansyl dyad DAE 1 is formed by linking two dansyl fluorophores covalently to a symmetrical dithienylethene backbone, whose photophysical properties can be reversibly switched by optical stimuli. Subsequently, the water insolubility of the molecular switch 1 is overcome by incorporating it into the bilayer of liposome DPPC (1,2-dihexadecanoyl-sn-glycero-3-phosphocholine) in water. This strategy creates stable fluorescent nano-aggregates OF-1@DPPC (≈25 nm diameter) that are soluble in an aqueous medium. The nano-aggregates OF-1@DPPC retain and even improve the photoswitchable fluorescence properties of DAE 1. More importantly, OF-1@DPPC exhibits a remarkable photostability and fatigue resistance after 5 cycles of irradiation with UV and visible light, which is crucial for its practical application.
authors.affiliation: Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, 100049, China.
authors.forename: Hongbo
authors.initials: H
authors.lastname: Cheng
authors.affiliation: Beijing National laboratory for Molecular Sciences, Key Laboratory of Photochemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.
authors.forename: Pin
authors.initials: P
authors.lastname: Ma
authors.affiliation: Beijing National laboratory for Molecular Sciences, Key Laboratory of Photochemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.
authors.forename: Yanan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, 100049, China.
authors.forename: Guofei
authors.initials: G
authors.lastname: Hu
authors.affiliation: Beijing National laboratory for Molecular Sciences, Key Laboratory of Photochemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.
authors.forename: Shibi
authors.initials: S
authors.lastname: Fang
authors.affiliation: Beijing National laboratory for Molecular Sciences, Key Laboratory of Photochemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.
authors.forename: Yanyan
authors.initials: Y
authors.lastname: Fang
authors.affiliation: Beijing National laboratory for Molecular Sciences, Key Laboratory of Photochemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Lin
mesh_terms: D003619:Dansyl Compounds / Q000737:chemistry*; D004355:Drug Stability; D005030:Ethylenes / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D008027:Light; D008081:Liposomes / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission; D015394:Molecular Structure; D053761:Nanocomposites / Q000737:chemistry*; D012995:Solubility; D014867:Water / Q000737:chemistry*
chemical_list: D003619:Dansyl Compounds; D005030:Ethylenes; D008081:Liposomes; D014867:Water; C036216:ethylene
keywords: liposomes; molecular switch; nano-aggregates; optical stimuli; photochromism