title: Analgesic Effect of Indian Gooseberry (Emblica officinalis Fruit) Extracts on Postoperative and Neuropathic Pain in Rats.
abstract: Indian gooseberry (Emblica officinalisfruit), also known as "Amla" is one of the oldest edible fruits known in India. It has also traditionally been used to treat inflammation, and as an analgesic to treat wounds. However, experimental evidence for the analgesic effects ofE. officinalishas been lacking. The present study investigated whetherE. officinalisextracts exhibit analgesic effects in the plantar incision (PI) and spared nerve injury (SNI) pain-model rats. We evaluated the mechanical withdrawal threshold (MWT) using von Frey filaments, and pain-related behavior was determined after surgery based on ultrasonic vocalization (USV). The group treated withE. officinalisextracts at 300 mg/kg had significantly increased MWT values at 6 h and 24 h after the PI, and had a significantly reduced number of 22-27-kHz USVs at 6 h and 24 h after PI. Moreover, after 15 days of continuous treatment withE.officinalisextracts, the treated group showed significantly alleviated SNI-induced hypersensitivity and reduced pro-inflammatory cytokine levels. Thus,E. officinalisextracts have potential analgesic effects in both postoperative and neuropathic pain models in vivo.
authors.affiliation: Research Group of Innovative Special Food, Korea Food Research Institute, 62, Anyangpangyo-ro, Bundang-gu, Seongnam 13539, Korea. neodw4015@kfri.re.kr.
authors.forename: Dong Wook
authors.initials: DW
authors.lastname: Lim
authors.affiliation: Research Group of Innovative Special Food, Korea Food Research Institute, 62, Anyangpangyo-ro, Bundang-gu, Seongnam 13539, Korea. Kim.Jae-goo@kfri.re.kr.
authors.forename: Jae Goo
authors.initials: JG
authors.lastname: Kim
authors.affiliation: Research Group of Innovative Special Food, Korea Food Research Institute, 62, Anyangpangyo-ro, Bundang-gu, Seongnam 13539, Korea. ytkim@kfri.re.kr.|Department of Food Biotechnology, Korea University of Science & Technology, 217 Gajeong-ro, Yuseong-gu, Daejeon 34113, Korea. ytkim@kfri.re.kr.
authors.forename: Yun Tai
authors.initials: YT
authors.lastname: Kim
mesh_terms: D000700:Analgesics / Q000737:chemistry / Q000627:therapeutic use*; D000818:Animals; D005638:Fruit / Q000737:chemistry*; D008297:Male; D009437:Neuralgia / Q000188:drug therapy*; D010149:Postoperative Pain / Q000188:drug therapy*; D029842:Phyllanthus emblica / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000700:Analgesics; D010936:Plant Extracts
keywords: Emblica officinalis; Indian gooseberry; analgesic effects; anti-inflammation; pain; plantar incision; spared nerve injury