title: A new sulfonylated flavonoid and other bioactive compounds isolated from the aerial parts of Cotula anthemoides L.
abstract: A new sulfonyl flavonol glucoside, 5,7,4',5'-tetrahydoxyflavonol 2'-[propanoic acid-(2″'-acetoxy-1″'-sulfonyl)]-5'-O-β-d-glucopyranoside (1) was isolated from the aerial parts of Cotula anthemoides L. in addition to 15 known compounds (2-16). The structure elucidation of these compounds was based on analyses of spectroscopic data including 1D-, 2D-NMR and HR-ESI-MS techniques and by comparing their NMR data with those reported in the literature. These compounds were evaluated for their DPPH radical scavenging and tyrosinase inhibitory activity. Compound 6 showed a high DPPH radical scavenging with EC50value of 9.1 ± 0.4 μM. Compound 11, 9 and 1 exhibited a mild tyrosinase inhibitory activity with IC50values of 85 ± 0.8, 95 ± 1.5 and 100 ± 0.5 μM, respectively.
authors.affiliation: a Département de chimie, Laboratoire d'Obtention des Substances Thérapeutiques (L.O.S.T) , Université des frères Mentouri Constantine , Constantine , Algeria.
authors.forename: Wafa
authors.initials: W
authors.lastname: Tadrent
authors.affiliation: b Groupe Isolement et Structure , Institut de Chimie Moléculaire de Reims (ICMR) , Reims , France.
authors.forename: Abdulmagid
authors.initials: A
authors.lastname: Alabdul Magid
authors.affiliation: a Département de chimie, Laboratoire d'Obtention des Substances Thérapeutiques (L.O.S.T) , Université des frères Mentouri Constantine , Constantine , Algeria.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Kabouche
authors.affiliation: c Service Commun d'Analyses , Institut de Chimie Moléculaire de Reims (ICMR) , Reims , France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Harakat
authors.affiliation: b Groupe Isolement et Structure , Institut de Chimie Moléculaire de Reims (ICMR) , Reims , France.
authors.forename: Laurence
authors.initials: L
authors.lastname: Voutquenne-Nazabadioko
authors.affiliation: a Département de chimie, Laboratoire d'Obtention des Substances Thérapeutiques (L.O.S.T) , Université des frères Mentouri Constantine , Constantine , Algeria.
authors.forename: Zahia
authors.initials: Z
authors.lastname: Kabouche
mesh_terms: D019659:Asteraceae / Q000737:chemistry*; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D016166:Free Radical Scavengers / Q000494:pharmacology; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors; D035261:Plant Components, Aerial / Q000737:chemistry
chemical_list: D005419:Flavonoids; D016166:Free Radical Scavengers; D014442:Monophenol Monooxygenase
keywords: Asteraceae; Cotula anthemoides; antioxidant activity; tyrosinase inhibitory activity