title: Ebola virus disease: An update on current prevention and management strategies.
abstract: Ebola virus disease (EVD) is characterised by systemic viral replication, immuno-suppression, abnormal inflammatory responses, large volume fluid and electrolyte losses, and high mortality in under-resourced settings. There are various therapeutic strategies targeting EVD including vaccines utilizing different antigen delivery methods, antibody-based therapies and antiviral drugs. These therapies remain experimental, but received attention following their use particularly in cases treated outside West Africa during the 2014-15 outbreak, in which 20 (80%) out of 25 patients survived. Emerging data from current trials look promising and are undergoing further study, however optimised supportive care remains the key to reducing mortality from EVD.
authors.affiliation: Department of Infectious Diseases, Wollongong Hospital, Wollongong, NSW, Australia; Graduate School of Medicine, University of Wollongong, Wollongong, Australia; Medecins Sans Frontieres, Paris, France. Electronic address: m.a.trad@hotmail.com.
authors.forename: M A
authors.initials: MA
authors.lastname: Trad
authors.affiliation: Department of Infectious Diseases, Monash Health, Clayton, Victoria, Australia.
authors.forename: W
authors.initials: W
authors.lastname: Naughton
authors.affiliation: Department of Infectious Diseases, Monash Health, Clayton, Victoria, Australia.
authors.forename: A
authors.initials: A
authors.lastname: Yeung
authors.affiliation: Medecins Sans Frontieres, Brussels, Belgium.
authors.forename: L
authors.initials: L
authors.lastname: Mazlin
authors.affiliation: Centre for Infectious Diseases and Microbiology, Pathology West, Westmead Hospital, NSW, Australia; Marie Bashir Institute for Infectious Diseases and Biosecurity, University of Sydney, NSW, Australia.
authors.forename: M
authors.initials: M
authors.lastname: O'sullivan
authors.affiliation: Centre for Infectious Diseases and Microbiology, Pathology West, Westmead Hospital, NSW, Australia.
authors.forename: N
authors.initials: N
authors.lastname: Gilroy
authors.affiliation: Division of Infectious Diseases, University Medicine Cluster, National University Hospital, Singapore; Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
authors.forename: D A
authors.initials: DA
authors.lastname: Fisher
authors.affiliation: Department of Infectious Diseases, Monash Health, Clayton, Victoria, Australia; Department of Medicine, Monash University, Victoria, Australia.
authors.forename: R L
authors.initials: RL
authors.lastname: Stuart
mesh_terms: D000349:Africa; D002986:Clinical Trials as Topic; D019142:Hemorrhagic Fever, Ebola / Q000517:prevention & control* / Q000628:therapy*; D006801:Humans
keywords: Ebola; Ebolavirus; Management; Outbreak; Therapeutics; Vaccines