title: Hitting the right button: MAVS-mediated defense against HAV infection.
abstract: Studying the immune response against infection with hepatitis viruses is hampered by the lack of suitable preclinical model systems. A recent publication in Science identifies the cytosolic adapter molecule MAVS as being responsible for species restriction of infection with hepatitis A virus as well as linking cytosolic immune sensing in infected hepatocytes with innate effector functions and protective adaptive immunity.
authors.affiliation: Institute of Molecular Immunology and Experimental Oncology Technische Universität München, Germany.
authors.forename: Percy A
authors.initials: PA
authors.lastname: Knolle
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D017957:Hepatitis A Virus, Human; D030041:Hepatitis A virus; D022781:Hepatocytes; D006801:Humans; D014774:Virulence
chemical_list: D048868:Adaptor Proteins, Signal Transducing