title: In SilicoEvaluation of the Potential Antiarrhythmic Effect of Epigallocatechin-3-Gallate on Cardiac Channelopathies.
abstract: Ion channels are transmembrane proteins that allow the passage of ions according to the direction of their electrochemical gradients. Mutations in more than 30 genes encoding ion channels have been associated with an increasingly wide range of inherited cardiac arrhythmias. In this line, ion channels become one of the most important molecular targets for several classes of drugs, including antiarrhythmics. Nevertheless, antiarrhythmic drugs are usually accompanied by some serious side effects. Thus, developing new approaches could offer added values to prevent and treat the episodes of arrhythmia. In this sense, green tea catechins seem to be a promising alternative because of the significant effect of Epigallocatechin-3-Gallate (E3G) on the electrocardiographic wave forms of guinea pig hearts. Thus, the aim of this study was to evaluate the benefits-risks balance of E3G consumption in the setting of ion channel mutations linked with aberrant cardiac excitability phenotypes. Two gain-of-function mutations, Nav1.5-p.R222Q and Nav1.5-p.I141V, which are linked with cardiac hyperexcitability phenotypes were studied. Computer simulations of action potentials (APs) show that 30μM E3G reduces and suppresses AP abnormalities characteristics of these phenotypes. These results suggest that E3G may have a beneficial effect in the setting of cardiac sodium channelopathies displaying a hyperexcitability phenotype.
authors.affiliation: Materials, Natural Substances, Environment and Modeling Laboratory, Multidisciplinary Faculty of Taza, University Sidi Mohamed Ben Abdellah, Fez, Morocco.
authors.forename: Maroua
authors.initials: M
authors.lastname: Boukhabza
authors.affiliation: Materials, Natural Substances, Environment and Modeling Laboratory, Multidisciplinary Faculty of Taza, University Sidi Mohamed Ben Abdellah, Fez, Morocco; Biology, Environment & Health Team, Department of Biology, Faculty of Sciences and Techniques Errachidia, University of Moulay Ismaïl, Meknes, Morocco; Department of Life and Earth Sciences, Regional Institute of Education and Training Careers, Fez, Morocco.
authors.forename: Jaouad
authors.initials: J
authors.lastname: El Hilaly
authors.affiliation: Biology, Environment & Health Team, Department of Biology, Faculty of Sciences and Techniques Errachidia, University of Moulay Ismaïl, Meknes, Morocco.
authors.forename: Nourdine
authors.initials: N
authors.lastname: Attiya
authors.affiliation: Team of Nutritional Physiology and Endocrine Pharmacology, Department of Biology, Faculty of Sciences and Techniques Errachidia, University of Moulay Ismaïl, Meknes, Morocco.
authors.forename: Ahmed
authors.initials: A
authors.lastname: El-Haidani
authors.affiliation: Biology, Environment & Health Team, Department of Biology, Faculty of Sciences and Techniques Errachidia, University of Moulay Ismaïl, Meknes, Morocco.
authors.forename: Younes
authors.initials: Y
authors.lastname: Filali-Zegzouti
authors.affiliation: Materials, Natural Substances, Environment and Modeling Laboratory, Multidisciplinary Faculty of Taza, University Sidi Mohamed Ben Abdellah, Fez, Morocco; Biology, Environment & Health Team, Department of Biology, Faculty of Sciences and Techniques Errachidia, University of Moulay Ismaïl, Meknes, Morocco.
authors.forename: Driss
authors.initials: D
authors.lastname: Mazouzi
authors.affiliation: Materials, Natural Substances, Environment and Modeling Laboratory, Multidisciplinary Faculty of Taza, University Sidi Mohamed Ben Abdellah, Fez, Morocco; Biology, Environment & Health Team, Department of Biology, Faculty of Sciences and Techniques Errachidia, University of Moulay Ismaïl, Meknes, Morocco.
authors.forename: Mohamed-Yassine
authors.identifier: 0000-0002-0523-1348
authors.initials: MY
authors.lastname: Amarouch
mesh_terms: D000200:Action Potentials; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000737:chemistry*; D002392:Catechin / Q000031:analogs & derivatives* / Q000737:chemistry; D053447:Channelopathies / Q000188:drug therapy*; D003198:Computer Simulation; D005419:Flavonoids / Q000737:chemistry; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects; D006325:Heart Atria / Q000503:physiopathology; D006352:Heart Ventricles / Q000503:physiopathology; D006801:Humans; D007477:Ions; D008955:Models, Cardiovascular; D032342:Muscle Cells / Q000166:cytology; D009154:Mutation; D009206:Myocardium / Q000473:pathology; D010641:Phenotype; D011689:Purkinje Cells / Q000166:cytology; D013662:Tea
chemical_list: D000889:Anti-Arrhythmia Agents; D005419:Flavonoids; D007477:Ions; D013662:Tea; D002392:Catechin; C045651:epigallocatechin gallate