title: Primary Diffuse Leptomeningeal Gliomatosis: Radiological/Pathological Features.
abstract: We present the case of a 43-year-old lady who presented with headaches, visual impairment, and seizures, progressing rapidly over the course of a few weeks. Extensive workup excluded an inflammatory or infectious cause. Imaging studies revealed diffuse thickening of the leptomeninges and serial CSF analysis showed raised opening pressures and increased protein levels. A diagnostic biopsy of the lower thoracic dura confirmed the diagnosis of primary diffuse leptomeningeal gliomatosis (PDGL). She was managed supportively for her symptoms and unfortunately she passed away a few weeks later.
authors.affiliation: East Kent Hospitals University NHS Trust, Queen Elizabeth the Queen Mother Hospital, Department of General Internal Medicine, Margate, UK.
authors.forename: Ehtasham
authors.identifier: 0000-0002-1359-9337
authors.initials: E
authors.lastname: Ahmad
authors.affiliation: East Kent Hospitals University NHS Trust, Queen Elizabeth the Queen Mother Hospital, Department of General Internal Medicine, Margate, UK.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Mohamed
authors.affiliation: East Kent Hospitals University NHS Trust, Queen Elizabeth the Queen Mother Hospital, Department of General Internal Medicine, Margate, UK; Teesside University, School of Health & Social Care, Middlesbrough, UK.
authors.forename: Apostolos
authors.identifier: 0000-0001-8752-9115
authors.initials: A
authors.lastname: Vrettos