title: Ventricular Fibrillation-Induced Cardiac Arrest Results in Regional Cardiac Injury Preferentially in Left Anterior Descending Coronary Artery Territory in Piglet Model.
abstract: Objective. Decreased cardiac function after resuscitation from cardiac arrest (CA) results from global ischemia of the myocardium. In the evolution of postarrest myocardial dysfunction, preferential involvement of any coronary arterial territory is not known. We hypothesized that there is no preferential involvement of any coronary artery during electrical induced ventricular fibrillation (VF) in piglet model.Design. Prospective, randomized controlled study.Methods. 12 piglets were randomized to baseline and electrical induced VF. After 5 min, the animals were resuscitated according to AHA PALS guidelines. After return of spontaneous circulation (ROSC), animals were observed for an additional 4 hours prior to cardiac MRI. Data (mean ± SD) was analyzed using unpairedt-test;pvalue ≤ 0.05 was considered statistically significant.Results. Segmental wall motion (mm; baseline versus postarrest group) in segment 7 (left anterior descending (LAD)) was 4.68 ± 0.54 versus 3.31 ± 0.64,p= 0.0026. In segment 13, it was 3.82 ± 0.96 versus 2.58 ± 0.82,p= 0.02. In segment 14, it was 2.42 ± 0.44 versus 1.29 ± 0.99,p= 0.028.Conclusion. Postarrest myocardial dysfunction resulted in segmental wall motion defects in the LAD territory. There were no perfusion defects in the involved segments.
authors.affiliation: Division of Pediatric Critical Care Medicine, Department of Pediatrics, University of Florida College of Medicine, Gainesville, FL, USA; Division of Pediatric Cardiology, Congenital Heart Center, Department of Pediatrics, University of Florida College of Medicine, Gainesville, FL, USA.
authors.forename: Giridhar Kaliki
authors.identifier: 0000-0003-4527-8818
authors.initials: GK
authors.lastname: Venkata
authors.affiliation: Divisions of Radiology and Biomedical Engineering, University of Florida, Gainesville, FL, USA.
authors.forename: John R
authors.initials: JR
authors.lastname: Forder
authors.affiliation: Divisions of Radiology and Biomedical Engineering, University of Florida, Gainesville, FL, USA.
authors.forename: Dan
authors.initials: D
authors.lastname: Clark
authors.affiliation: Department of Anesthesiology, College of Veterinarian School, University of Florida, Gainesville, FL, USA.
authors.forename: Andre
authors.initials: A
authors.lastname: Shih
authors.affiliation: Division of Pediatric Hospitalist Medicine, Department of Pediatrics, University of Florida College of Medicine, Gainesville, FL, USA; Department of Pediatrics, Sidra Research and Medical Center, Doha, Qatar.
authors.forename: Sharda
authors.initials: S
authors.lastname: Udassi
authors.affiliation: Division of Pediatric Critical Care, Department of Pediatrics, Texas Tech University Health Sciences, El Paso Children's Hospital, El Paso, TX, USA.
authors.forename: Srinivasarao
authors.initials: S
authors.lastname: Badugu
authors.affiliation: Division of Pediatric Critical Care Medicine, Department of Pediatrics, University of Florida College of Medicine, Gainesville, FL, USA.
authors.forename: Melissa A
authors.initials: MA
authors.lastname: Lamb
authors.affiliation: Division of Pediatric Cardiology, Congenital Heart Center, Department of Pediatrics, University of Florida College of Medicine, Gainesville, FL, USA.
authors.forename: Stacy L
authors.initials: SL
authors.lastname: Porvasnik
authors.affiliation: Division of Pediatric Cardiology, Congenital Heart Center, Department of Pediatrics, University of Florida College of Medicine, Gainesville, FL, USA.
authors.forename: Renata S
authors.initials: RS
authors.lastname: Shih
authors.affiliation: Division of Pediatric Cardiology, Congenital Heart Center, Department of Pediatrics, University of Florida College of Medicine, Gainesville, FL, USA.
authors.forename: Dalia
authors.initials: D
authors.lastname: Colon-Lopez
authors.affiliation: Department of Pediatrics, Children's Hospital of The King's Daughters, Eastern Virginia Medical School, Norfolk, VA, USA.
authors.forename: Arno L
authors.initials: AL
authors.lastname: Zaritsky
authors.affiliation: Division of Pediatric Critical Care, Department of Pediatrics, University of Texas Health Science Center at Houston, Houston, TX, USA.
authors.forename: Ikram U
authors.identifier: 0000-0001-9135-379X
authors.initials: IU
authors.lastname: Haque
authors.affiliation: Division of Pediatric Cardiology, Congenital Heart Center, Department of Pediatrics, University of Florida College of Medicine, Gainesville, FL, USA; Department of Pediatrics, Sidra Research and Medical Center, Doha, Qatar.
authors.forename: Jai P
authors.identifier: 0000-0002-0109-3478
authors.initials: JP
authors.lastname: Udassi
mesh_terms: D000818:Animals; D009202:Cardiomyopathies / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology*; D003324:Coronary Artery Disease / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D005260:Female; D006323:Heart Arrest / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology*; D008297:Male; D013318:Stroke Volume; D013552:Swine; D014693:Ventricular Fibrillation / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology*