title: Exercise Mimetics: Impact on Health and Performance.
abstract: The global epidemic of obesity and its associated chronic diseases is largely attributed to an imbalance between caloric intake and energy expenditure. While physical exercise remains the best solution, the development of muscle-targeted "exercise mimetics" may soon provide a pharmaceutical alternative to battle an increasingly sedentary lifestyle. At the same time, these advances are fueling a raging debate on their escalating use as performance-enhancing drugs in high-profile competitions such as the Olympics.
authors.affiliation: Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
authors.forename: Weiwei
authors.initials: W
authors.lastname: Fan
authors.affiliation: Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA; Howard Hughes Medical Institute, Salk Institute for Biological Studies, La Jolla, CA 92037, USA. Electronic address: evans@salk.edu.
authors.forename: Ronald M
authors.initials: RM
authors.lastname: Evans
mesh_terms: D000263:Adenylate Kinase / Q000378:metabolism; D015444:Exercise / Q000502:physiology*; D016678:Genome; D006262:Health; D006801:Humans; D018482:Muscle, Skeletal / Q000502:physiology; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism
chemical_list: D018160:Receptors, Cytoplasmic and Nuclear; D000263:Adenylate Kinase
keywords: exercise; exercise mimetics; skeletal muscle