title: Bridging the gap to therapeutic strategies based on connexin/pannexin biology.
abstract: A unique workshop was recently held focusing on enhancing collaborations leading to identify and update the development of therapeutic strategies targeting connexin/pannexin large pore channels. Basic scientists exploring the functions of these channels in various pathologies gathered together with leading pharma companies which are targeting gap junction proteins for specific therapeutic applications. This highlights how paths of discovery research can converge with therapeutic strategies in innovative ways to enhance target identification and validation.
authors.affiliation: Department of Cellular and Physiological Sciences, Faculty of Medicine, Life Sciences Institute, University of British Columbia, 2350 Health Sciences Mall, Vancouver, BC, V6T 1Z3, Canada. cnaus@interchange.ubc.ca.
authors.forename: Christian C
authors.initials: CC
authors.lastname: Naus
authors.affiliation: ICIRB, CNRS UMR7241/INSERM U1050, Collège de France, Paris Cedex 05, France.
authors.forename: Christian
authors.initials: C
authors.lastname: Giaume
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D017630:Connexins / Q000737:chemistry / Q000378:metabolism*; D004194:Disease; D006801:Humans; D058990:Molecular Targeted Therapy; D009419:Nerve Tissue Proteins / Q000737:chemistry / Q000378:metabolism*
chemical_list: D017630:Connexins; D009419:Nerve Tissue Proteins
keywords: Connexins; Gap junctions; Pannexins; Peptides; Strategies; Therapeutics