title: Chemical Composition, an Antioxidant, Cytotoxic and Microbiological Activity of the Essential Oil from the Leaves of Aeollanthus suaveolens Mart. ex Spreng.
abstract: Aeollanthus suaveolens species popularly known as catinga de mulata belongs to the Lamiaceae family. In the Amazon region, it is used in folk medicine for the treatment of gastritis, convulsions of epileptic origin, stomach pain and diarrhea in the form of tea and juice. Essential oils have analgesic, anti-inflammatory, and antimicrobial activity. This study evaluated the chemical composition of the A. suaveolens essential oil, and its cytotoxic, antimicrobial and antioxidant activity on Artemia salina Leach. The plant species was collected in Fazendinha district in the city of Macapa-AP. The essential oil obtained from the process was performed by hydrodistillation and identification of components by gas chromatography coupled with mass spectrometer. The antioxidant activity was evaluated by the kidnapping method of 2,2- diphenyl -1-picrilhidrazil radical, while the cytotoxic activity was assessed using saline A. and the microbiological activity was carried out by microdilution method with Escherichia coli, Salmonella sp. and Staphylococcus aureus bacteria. In a chromatographic analysis, the major constituents found in the essential oil of A. suaveolens were (E) -β-farnesene (37.615%), Linalool (33.375%), α-Santalene (3.255%) and linalyl acetate (3.222%). The results showed that the Escherichia coli and Salmonella sp. bacteria were more susceptible to MIC 50 mg.mL-1 when compared with the Staphylococcus aureus bacterium MIC 100 mg.mL-1. With respect to MBC concentration of 100 mg.mL-1 it was sufficient to inhibit the growth of E. coli. The essential oil did not show antioxidant activity, however, has a high cytotoxic activity against the A. salina, LC50 8.90 μg.mL-1.
authors.affiliation: Laboratory of Pharmacognosy and Phytochemistry-Federal University of Amapá, Macapá-Amapá, Brazil.
authors.forename: Rosany Lopes
authors.initials: RL
authors.lastname: Martins
authors.affiliation: Laboratory of Pharmacognosy and Phytochemistry-Federal University of Amapá, Macapá-Amapá, Brazil.
authors.forename: Ranggel Carvalho
authors.initials: RC
authors.lastname: Simões
authors.affiliation: Laboratory of Pharmacognosy and Phytochemistry-Federal University of Amapá, Macapá-Amapá, Brazil.
authors.forename: Érica de Menezes
authors.initials: ÉM
authors.lastname: Rabelo
authors.affiliation: Laboratory of Pharmacognosy and Phytochemistry-Federal University of Amapá, Macapá-Amapá, Brazil.
authors.forename: Ana Luzia Ferreira
authors.initials: AL
authors.lastname: Farias
authors.affiliation: Laboratory of Pharmacognosy and Phytochemistry-Federal University of Amapá, Macapá-Amapá, Brazil.
authors.forename: Alex Bruno Lobato
authors.initials: AB
authors.lastname: Rodrigues
authors.affiliation: Laboratory of Pharmacognosy and Phytochemistry-Federal University of Amapá, Macapá-Amapá, Brazil.
authors.forename: Ryan da Silva
authors.initials: RD
authors.lastname: Ramos
authors.affiliation: Department of Chemical, Federal University of São Carlos, São Carlos - São Paulo - Brazil.
authors.forename: João Batista
authors.initials: JB
authors.lastname: Fernandes
authors.affiliation: Laboratory of Chemistry, Federal University of Pará, Belém - Pará - Brasil.
authors.forename: Lourivaldo da Silva
authors.initials: LD
authors.lastname: Santos
authors.affiliation: Laboratory of Pharmacognosy and Phytochemistry-Federal University of Amapá, Macapá-Amapá, Brazil.
authors.forename: Sheylla Susan Moreira da Silva
authors.identifier: http://orcid.org/0000-0002-7687-8288
authors.initials: SS
authors.lastname: de Almeida
mesh_terms: D000080462:Acyclic Monoterpenes; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology*; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects / Q000472:pathogenicity; D019686:Lamiaceae / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D039821:Monoterpenes / Q000737:chemistry / Q000494:pharmacology; D009822:Oils, Volatile / Q000737:chemistry / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes / Q000737:chemistry / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects / Q000472:pathogenicity
chemical_list: D000080462:Acyclic Monoterpenes; D000890:Anti-Infective Agents; D000975:Antioxidants; D039821:Monoterpenes; D009822:Oils, Volatile; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; C577370:alpha-santalene; C062671:beta-farnesene; C074463:linalyl acetate; C018584:linalool