title: Lower Vitamin D Metabolites Levels Were Associated With Increased Coronary Artery Diseases in Type 2 Diabetes Patients in India.
abstract: The purpose of the present study was to measure six vitamin D metabolites and to find the association between vitamin D deficiency and coronary artery diseases in diabetes (T2DM_CAD). Four groups [control (n = 50), type 2 diabetes (T2DM, n = 71), coronary artery diseases (CAD, n = 28), T2DM_CAD (n = 38)] of total 187 subjects were included in the study. Six vitamin D metabolites (D2, D3, 25(OH)D2, 25(OH)D3, 1,25(OH)2D2, 1,25(OH)2D3), total 25(OH)D and total 1,25(OH)2D were measured by UPLC/APCI/HRMS method in these subjects. Although all the vitamin D metabolites were significantly decreased in T2DM_CAD as compared to both control and T2DM subjects (p < 0.05), only two metabolites i.e., 25(OH)D3and total 25(OH)D were significantly (p < 0.05) decreased in the T2DM subjects as compared with the control subjects (p < 0.05). Vitamin D3, 1,25(OH)2D2, 25(OH)D, and 1,25(OH)2D levels were significantly decreased in T2DM_CAD subjects as compared with CAD subjects (p < 0.05). Further, multiple logistic regression analysis revealed that total 25(OH)D and total 1,25(OH)2D can be used to predict T2DM (OR 0.82.95% CI 0.68-0.99; p = 0.0208) and T2DM with CAD (OR 0.460, 95% CI 0.242-0.874; p = 0.0177), respectively. Our data concludes that lower concentration of 1,25(OH)2D is associated with type 2 diabetes coexisting with coronary artery diseases in South Indian subjects.
authors.affiliation: Drug Discovery Research Center, Translational Health Science and Technology Institute (THSTI), Faridabad, HR-121001 (RA, SKB), India.
authors.forename: Ramu
authors.initials: R
authors.lastname: Adela
authors.affiliation: National Center for Mass Spectrometry, Indian Institute of Chemical Technology (CSIR-IICT), Hyderabad (RMB, MMB, RS), India.
authors.forename: Roshan M
authors.initials: RM
authors.lastname: Borkar
authors.affiliation: National Center for Mass Spectrometry, Indian Institute of Chemical Technology (CSIR-IICT), Hyderabad (RMB, MMB, RS), India.
authors.forename: Murali Mohan
authors.initials: MM
authors.lastname: Bhandi
authors.affiliation: Clinical Development Service Agency (CDSA), Translational Health Science and Technology Institute (THSTI), Faridabad, HR-121001 (GV), India.
authors.forename: Gayatri
authors.initials: G
authors.lastname: Vishwakarma
authors.affiliation: Cardiology Division, Mediciti Hospitals, Hyderabad-500063 (PNCR), India.
authors.forename: P Naveen Chander
authors.initials: PN
authors.lastname: Reddy
authors.affiliation: National Center for Mass Spectrometry, Indian Institute of Chemical Technology (CSIR-IICT), Hyderabad (RMB, MMB, RS), India.
authors.forename: R
authors.initials: R
authors.lastname: Srinivas
authors.affiliation: Drug Discovery Research Center, Translational Health Science and Technology Institute (THSTI), Faridabad, HR-121001 (RA, SKB), India.
authors.forename: Sanjay K
authors.initials: SK
authors.lastname: Banerjee
mesh_terms: D000886:Anthropometry; D001786:Blood Glucose / Q000378:metabolism; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000097:blood* / Q000150:complications*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications*; D005215:Fasting / Q000097:blood; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D007194:India; D016015:Logistic Models; D008297:Male; D055442:Metabolome; D008875:Middle Aged; D014807:Vitamin D / Q000097:blood*
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; D014807:Vitamin D