title: Role of Anti-inflammatory Cytokines IL-35 and IL-37 in Asthma.
abstract: Asthma is a chronic airway inflammation that is characterized by intense eosinophil infiltrates, mucus hypersecretion, airway remodeling, and airway hyperresponsiveness. Interleukin (IL)-35 and IL-37 are two cytokines with anti-inflammatory effects found in immune response. Recent findings suggested that expressions of IL-35 and IL-37 are abnormal in asthma. Functional analysis further confirmed the important roles of them in the pathogenesis of asthma. The present study reviewed the updated evidence indicating the roles of IL-35 and IL-37 in asthma. Hopefully, the information obtained may lead to a better understanding of the pathogenesis of the disease.
authors.affiliation: Department of Respiratory Medicine, Affiliated Anhui Provincial Hospital, Anhui Medical University, 17 Lujiang Road, Hefei, Anhui, 230001, China. Hudaiju@163.com.
authors.forename: Daiju
authors.initials: D
authors.lastname: Hu
mesh_terms: D000818:Animals; D001249:Asthma / Q000209:etiology / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007249:Inflammation; D018836:Inflammation Mediators / Q000276:immunology / Q000502:physiology*; D007375:Interleukin-1 / Q000276:immunology / Q000502:physiology*; D007378:Interleukins / Q000276:immunology / Q000502:physiology*
chemical_list: C508587:IL37 protein, human; D018836:Inflammation Mediators; D007375:Interleukin-1; D007378:Interleukins; C532417:interleukin-35, human
keywords: IL-35; IL-37; asthma