title: Big endothelin-1 level is a useful marker for predicting the presence of isolated coronary artery ectasia.
abstract: BACKGROUND
  Endothelin-1(ET-1) has been implicated in coronary artery disease (CAD) and may be associated with coronary artery ectasia (CAE).
  
  
  OBJECTIVE
  To clarify the relationship between big ET-1 and isolated CAE.
  
  
  METHODS
  We measured big ET-1 with ELISA in 216 patients (CAE, n = 72; CAD, n = 72; normal, n = 72) and evaluated the link with isolated CAE.
  
  
  RESULTS
  The level of plasma big ET-1 was significantly higher in patients with isolated CAE (p < 0.001). Big ET-1 was strongly and independently associated with CAE by multivariate analysis (OR 95%CI: 1.026 (1.018-1.034), p = 0.000).
  
  
  CONCLUSIONS
  Big ET-1 may be a useful predictor for the presence of isolated CAE.
authors.affiliation: a Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease , Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing , China.
authors.forename: Yao
authors.initials: Y
authors.lastname: Wang
authors.affiliation: a Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease , Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing , China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: a Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease , Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing , China.
authors.forename: Cheng-Gang
authors.initials: CG
authors.lastname: Zhu
authors.affiliation: a Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease , Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing , China.
authors.forename: Yuan-Lin
authors.initials: YL
authors.lastname: Guo
authors.affiliation: a Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease , Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing , China.
authors.forename: Qiao-Juan
authors.initials: QJ
authors.lastname: Huang
authors.affiliation: a Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease , Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing , China.
authors.forename: Na-Qiong
authors.initials: NQ
authors.lastname: Wu
authors.affiliation: a Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease , Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing , China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Gao
authors.affiliation: a Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease , Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing , China.
authors.forename: Ping
authors.initials: P
authors.lastname: Qing
authors.affiliation: a Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease , Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing , China.
authors.forename: Geng
authors.initials: G
authors.lastname: Liu
authors.affiliation: a Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease , Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing , China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Dong
authors.affiliation: a Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease , Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing , China.
authors.forename: Jian-Jun
authors.initials: JJ
authors.lastname: Li
mesh_terms: D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000097:blood / Q000175:diagnosis*; D004108:Dilatation, Pathologic / Q000097:blood / Q000175:diagnosis*; D019332:Endothelin-1 / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011237:Predictive Value of Tests
chemical_list: D015415:Biomarkers; D019332:Endothelin-1
keywords: Big endothelin-1; coronary artery disease; coronary artery ectasia