title: Antiproliferative Effect of Indole Phytoalexins.
abstract: Indole phytoalexins from crucifers have been shown to exhibit significant anti-cancer, chemopreventive, and antiproliferative activity. Phytoalexins are natural low molecular antimicrobial compounds that are synthesized and accumulated in plants after their exposure to pathogenic microorganisms. Most interestingly, crucifers appear to be the only plant family producing sulfur-containing indole phytoalexins. The mechanisms underlying its anti-cancer properties are unknown. Isolation from cruciferous plants does not provide sufficient quantities of indole phytoalexins and, for biological screening, they are usually obtainable through synthesis. Understanding the molecular mechanism of the action of these substances and their structure-activity relationships is quite important in the development of new analogs with a more favorable profile of biological activities. In this review, we present the key features of indole phytoalexins, mainly their antiproliferative ativities.
authors.affiliation: Department of Pharmacology, Faculty of Medicine, P.J. Šafárik University, 040 11 Košice, Slovakia. chripkova.martina@gmail.com.|Department of Human and Clinical Pharmacology, University of Veterinary Medicine and Pharmacy, 040 11 Košice, Slovakia. chripkova.martina@gmail.com.
authors.forename: Martina
authors.initials: M
authors.lastname: Chripkova
authors.affiliation: Department of Animal Breeding, University of Veterinary Medicine and Pharmacy, 040 11 Košice, Slovakia. frantisek.zigo@uvlf.sk.
authors.forename: Frantisek
authors.initials: F
authors.lastname: Zigo
authors.affiliation: Department of Pharmacology, Faculty of Medicine, P.J. Šafárik University, 040 11 Košice, Slovakia. jan.mojzis@upjs.sk.
authors.forename: Jan
authors.initials: J
authors.lastname: Mojzis
mesh_terms: D019607:Brassicaceae / Q000737:chemistry*; D049109:Cell Proliferation / Q000187:drug effects*; D006801:Humans; D007211:Indoles / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000737:chemistry / Q000494:pharmacology*; D014407:Tumor Cells, Cultured; D000094162:Phytoalexins
chemical_list: D007211:Indoles; D012717:Sesquiterpenes; C030374:indole; D000094162:Phytoalexins
keywords: antiproliferative; brassinin; cancer; crucifers; indole phytoalexins