title: Functional Connectivity of Child and Adolescent Attention Deficit Hyperactivity Disorder Patients: Correlation with IQ.
abstract: Attention deficit hyperactivity disorder (ADHD) is a pervasive neuropsychological disorder that affects both children and adolescents. Child and adolescent ADHD patients exhibit different behavioral symptoms such as hyperactivity and impulsivity, but not much connectivity research exists to help explain these differences. We analyzed openly accessible resting-state functional magnetic resonance imaging (rs-fMRI) data on 112 patients (28 child ADHD, 28 adolescent ADHD, 28 child normal control (NC), and 28 adolescent NC). We used group independent component analysis (ICA) and weighted degree values to identify interaction effects of age (child and adolescent) and symptom (ADHD and NC) in brain networks. The frontoparietal network showed significant interaction effects (p= 0.0068). The frontoparietal network is known to be related to hyperactive and impulsive behaviors. Intelligence quotient (IQ) is an important factor in ADHD, and we predicted IQ scores using the results of our connectivity analysis. IQ was predicted using degree centrality values of networks with significant interaction effects of age and symptom. Actual and predicted IQ scores demonstrated significant correlation values, with an error of about 10%. Our study might provide imaging biomarkers for future ADHD and intelligence studies.
authors.affiliation: Department of Electronic, Electrical and Computer Engineering, Sungkyunkwan University Suwon, Korea.
authors.forename: Bo-Yong
authors.initials: BY
authors.lastname: Park
authors.affiliation: Department of Electronic, Electrical and Computer Engineering, Sungkyunkwan University Suwon, Korea.
authors.forename: Jisu
authors.initials: J
authors.lastname: Hong
authors.affiliation: Department of Electronic, Electrical and Computer Engineering, Sungkyunkwan University Suwon, Korea.
authors.forename: Seung-Hak
authors.initials: SH
authors.lastname: Lee
authors.affiliation: School of Electronic and Electrical Engineering, Sungkyunkwan UniversitySuwon, Korea; Center for Neuroscience Imaging Research (CNIR), Institute for Basic Science, Sungkyunkwan UniversitySuwon, Korea.
authors.forename: Hyunjin
authors.initials: H
authors.lastname: Park
keywords: IQ; attention deficit hyperactivity disorder; connectivity; group ICA; resting-state fMRI