title: AAPT Diagnostic Criteria for Chronic Cancer Pain Conditions.
abstract: Chronic cancer pain is a serious complication of malignancy or its treatment. Currently, no comprehensive, universally accepted cancer pain classification system exists. Clarity in classification of common cancer pain syndromes would improve clinical assessment and management. Moreover, an evidence-based taxonomy would enhance cancer pain research efforts by providing consistent diagnostic criteria, ensuring comparability across clinical trials. As part of a collaborative effort between the Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks (ACTTION) and the American Pain Society (APS), the ACTTION-APS Pain Taxonomy initiative worked to develop the characteristics of an optimal diagnostic system. After the establishment of these characteristics, a working group consisting of clinicians and clinical and basic scientists with expertise in cancer and cancer-related pain was convened to generate core diagnostic criteria for an illustrative sample of 3 chronic pain syndromes associated with cancer (ie, bone pain and pancreatic cancer pain as models of pain related to a tumor) or its treatment (ie, chemotherapy-induced peripheral neuropathy). A systematic review and synthesis was conducted to provide evidence for the dimensions that comprise this cancer pain taxonomy. Future efforts will subject these diagnostic categories and criteria to systematic empirical evaluation of their feasibility, reliability, and validity and extension to other cancer-related pain syndromes.
  
  
  
  The ACTTION-APS chronic cancer pain taxonomy provides an evidence-based classification for 3 prevalent syndromes, namely malignant bone pain, pancreatic cancer pain, and chemotherapy-induced peripheral neuropathy. This taxonomy provides consistent diagnostic criteria, common features, comorbidities, consequences, and putative mechanisms for these potentially serious cancer pain conditions that can be extended and applied with other cancer-related pain syndromes.
authors.affiliation: Division of Hematology-Oncology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois. Electronic address: j-paice@northwestern.edu.
authors.forename: Judith A
authors.initials: JA
authors.lastname: Paice
authors.affiliation: Academic Unit of Palliative Care, Leeds Institute of Health Sciences, University of Leeds, Leeds, United Kingdom.
authors.forename: Matt
authors.initials: M
authors.lastname: Mulvey
authors.affiliation: Academic Unit of Palliative Care, Leeds Institute of Health Sciences, University of Leeds, Leeds, United Kingdom.
authors.forename: Michael
authors.initials: M
authors.lastname: Bennett
authors.affiliation: The Division of Anesthesia and Critical Care Medicine, The University of Texas M.D. Anderson Cancer Center, Houston, Texas.
authors.forename: Patrick M
authors.initials: PM
authors.lastname: Dougherty
authors.affiliation: Department of Epidemiology, Neurology, and Anesthesia, University of Pennsylvania, Philadelphia, Pennsylvania.
authors.forename: John T
authors.initials: JT
authors.lastname: Farrar
authors.affiliation: Department of Pharmacology, University of Arizona, Tucson, Arizona.
authors.forename: Patrick W
authors.initials: PW
authors.lastname: Mantyh
authors.affiliation: Department of Physiological Nursing, University of California, San Francisco, California.
authors.forename: Christine
authors.initials: C
authors.lastname: Miaskowski
authors.affiliation: Bluestone Center for Clinical Research, New York University College of Dentistry, New York, New York.
authors.forename: Brian
authors.initials: B
authors.lastname: Schmidt
authors.affiliation: Department of Oncology, The Johns Hopkins Hospital, Baltimore, Maryland.
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Smith
mesh_terms: D000072716:Cancer Pain / Q000175:diagnosis*; D059350:Chronic Pain / Q000175:diagnosis; D019317:Evidence-Based Medicine; D006801:Humans; D010147:Pain Measurement / Q000379:methods* / Q000592:standards; D055818:Public-Private Sector Partnerships; D012955:Societies, Medical / Q000592:standards*; D014481:United States
keywords: Cancer pain; bone pain; chemotherapy-induced peripheral neuropathy; pancreatic cancer; taxonomy