title: Hypolipidemic Effect of Mannan in Mice with Acute Lipemia Induced by Poloxamer 407.
abstract: We studied biological effects of mannan, a polysaccharide immunomodulator from C. albicans, that interacts with mannose receptor in vivo. It is shown that preliminary administration of mannan (5 times in a dose of 50 mg/kg or 2 times in a dose of 100 mg/kg) to mice with acute lipemia induced by lipase inhibitor poloxamer 407 (300 mg/kg) reduces the serum concentrations of atherogenic LDL, cholesterol, and triglycerides. Administration of mannan to intact mice and animals with acute lipemia reduces triglyceride concentration and causes labilization of lysosomal membranes in the liver. Serum activity of chitotriosidase, a marker of macrophage activation, was elevated in mice with acute lipemia treated with mannan. Thus, mannan from C. albicans is a promising hypolipidemic polysaccharide compound, similar by its activity to β-glycan, a component of LPS.
authors.affiliation: Research Institute of Physiology and Fundamental Medicine, Novosibirsk, Russia.
authors.forename: N V
authors.initials: NV
authors.lastname: Goncharova
authors.affiliation: Research Institute of Physiology and Fundamental Medicine, Novosibirsk, Russia.
authors.forename: M V
authors.initials: MV
authors.lastname: Khrapova
authors.affiliation: Research Institute of Physiology and Fundamental Medicine, Novosibirsk, Russia.
authors.forename: A B
authors.initials: AB
authors.lastname: Pupyshev
authors.affiliation: University Canada West, Vancouver, Canada.
authors.forename: E Ts
authors.initials: ET
authors.lastname: Korolenko
authors.affiliation: Institute of Chemistry, Slovak Academy of Sciences, Bratislava, Slovakia.
authors.forename: Z
authors.initials: Z
authors.lastname: Nešéáková
authors.affiliation: Research Institute of Physiology and Fundamental Medicine, Novosibirsk, Russia. t.a.korolenko@physiol.ru.
authors.forename: T A
authors.initials: TA
authors.lastname: Korolenko
mesh_terms: D000818:Animals; D002176:Candida albicans / Q000737:chemistry; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D062610:Fungal Polysaccharides / Q000302:isolation & purification / Q000494:pharmacology*; D006596:Hexosaminidases / Q000097:blood; D006949:Hyperlipidemias / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D007274:Injections, Intraperitoneal; D007425:Intracellular Membranes / Q000737:chemistry / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008247:Lysosomes / Q000737:chemistry / Q000187:drug effects; D008262:Macrophage Activation / Q000187:drug effects; D008264:Macrophages / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008351:Mannans / Q000302:isolation & purification / Q000494:pharmacology*; D051379:Mice; D008808:Mice, Inbred CBA; D020442:Poloxamer / Q000494:pharmacology*; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D062610:Fungal Polysaccharides; D008351:Mannans; D014280:Triglycerides; D020442:Poloxamer; D006596:Hexosaminidases; C086400:chitotriosidase
keywords: lipemia; macrophages; mannan; poloxamer 407