title: Chemistry of Heterocyclic Five and Six Membered Enamino Nitriles and Enamino Esters.
abstract: Progress in the chemistry of cyclic enamino-nitriles based on the advanced synthetic methodologies is reported. Due to the recent accomplishment, it becomes possible to reactivate these molecules toward electrophiles, nucleophiles and as electron rich dienes in 2+3 dipolar additions and in 4+2 cycloadditions reactions. Synthesizing the poly functionalized 4H-pyrans and their fused derivatives is a fascinating field with a multitude of biological implications such as antitumor, cardiotonic, hepatoprotective, antihypertensive, antibronchitis, as well antifungal activity. This work was conducted with particular emphasis on reviewing the work done on the cyclic enamines since 1990 up till now in order to highlight in more details the synthetic pathways, interactions and the biological activities, Furthermore; we referred to the recent original data of our group contributions within this field.
authors.affiliation: Department of Chemistry, Faculty of Science; University of Kuwait: Safat; 13060, P.O. Box 5969, Kuwait.
authors.forename: Moustafa Sherief
authors.initials: MS
authors.lastname: Moustafa
authors.affiliation: Department of Chemistry, Faculty of Science; University of Kuwait: Safat; 13060, P.O. Box 5969, Kuwait.
authors.forename: Saleh Mohammed
authors.initials: SM
authors.lastname: Al-Mousawi
authors.affiliation: Division of Pharmacognosy, Department of Medicinal Chemistry, Uppsala University, Biomedical Centre, Box 574, SE-751 23, Uppsala, Sweden.|Research Institute of Chemistry, International Centre for Chemical and Biological Sciences (ICCBS), University of Karachi, Karachi-75270, Pakistan.|Chemistry Department, Faculty of Science, Menoufia University, Menoufia, Egypt.
authors.forename: Hesham R
authors.initials: HR
authors.lastname: El-Seedi
authors.affiliation: Department of Chemistry, Faculty of Science, Cairo University, P.O. Box 12613, Giza, Egypt.
authors.forename: Mohamed Hilmy
authors.initials: MH
authors.lastname: Elnagdi
mesh_terms: D000588:Amines / Q000138:chemical synthesis / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004952:Esters / Q000138:chemical synthesis / Q000737:chemistry*; D006576:Heterocyclic Compounds, 4 or More Rings / Q000138:chemical synthesis / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D009570:Nitriles / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D000588:Amines; D004952:Esters; D006576:Heterocyclic Compounds, 4 or More Rings; D009570:Nitriles
keywords: Cyclic enamines; biological activity; cycloaddition; electrophiles; functionally substituted enamines; nucleophiles.