title: Maxillofacial Defects and the Use of Growth Factors.
abstract: The development and increase in knowledge of the benefits and applications of growth factors in craniofacial reconstruction adds a novel tool in the reconstructive surgeon's armamentarium. The use of growth factors varies according to presentation. Growth factors help to promote healing, angiogenesis, and formation of bone of improved quality and quantity. Growth factors used with stem cells and scaffolds provide a solution or alternative to discomfort created by donor autograft sites. The application and results of these growth factors are displayed in various examples of maxillofacial defects in this article, including reconstruction of a premaxillary cleft and of maxillary augmentation.
authors.affiliation: Oral & Maxillofacial Surgery, Loma Linda University, 11092 Anderson Street, Loma Linda, CA 92350, USA. Electronic address: aherford@llu.edu.
authors.forename: Alan S
authors.initials: AS
authors.lastname: Herford
authors.affiliation: Oral & Maxillofacial Surgery, Loma Linda University, 11092 Anderson Street, Loma Linda, CA 92350, USA.
authors.forename: Meagan
authors.initials: M
authors.lastname: Miller
authors.affiliation: Oral Surgery, Department of Dental Implants, University of Milan, Via Commenda 10, Milan 20122, Italy.
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Signorino
mesh_terms: D000540:Alveolar Ridge Augmentation / Q000379:methods; D016025:Bone Transplantation / Q000379:methods*; D019465:Craniofacial Abnormalities / Q000601:surgery; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000494:pharmacology*; D018919:Neovascularization, Physiologic / Q000187:drug effects; D019647:Oral Surgical Procedures / Q000379:methods*; D010012:Osteogenesis / Q000187:drug effects; D019651:Plastic Surgery Procedures / Q000379:methods*; D044968:Regenerative Medicine / Q000379:methods*; D033581:Stem Cell Transplantation; D054457:Tissue Scaffolds; D014945:Wound Healing / Q000187:drug effects
chemical_list: D036341:Intercellular Signaling Peptides and Proteins
keywords: BMP; Grafts; Growth factors; Maxillofacial defects; Regenerative medicine