title: Regulated Proteolysis in Bacteria: Caulobacter.
abstract: Protein degradation is essential for all living things. Bacteria use energy-dependent proteases to control protein destruction in a highly specific manner. Recognition of substrates is determined by the inherent specificity of the proteases and through adaptor proteins that alter the spectrum of substrates. In the α-proteobacterium Caulobacter crescentus, regulated protein degradation is required for stress responses, developmental transitions, and cell cycle progression. In this review, we describe recent progress in our understanding of the regulated and stress-responsive protein degradation pathways in Caulobacter. We discuss how organization of highly specific adaptors into functional hierarchies drives destruction of proteins during the bacterial cell cycle. Because all cells must balance the need for degradation of many true substrates with the toxic consequences of nonspecific protein destruction, principles found in one system likely generalize to others.
authors.affiliation: Molecular and Cellular Biology Graduate Program and.
authors.forename: Kamal Kishore
authors.initials: KK
authors.lastname: Joshi
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, Massachusetts 01003; email: pchien@biochem.umass.edu.
authors.forename: Peter
authors.initials: P
authors.lastname: Chien
mesh_terms: D001426:Bacterial Proteins / Q000378:metabolism*; D016934:Caulobacter / Q000166:cytology / Q000378:metabolism*; D002453:Cell Cycle; D010447:Peptide Hydrolases / Q000378:metabolism; D059748:Proteolysis; D013312:Stress, Physiological
chemical_list: D001426:Bacterial Proteins; D010447:Peptide Hydrolases
keywords: AAA+ protease; ClpAP; ClpXP; Lon; adaptor; cell cycle