title: Intestinal Microbiota as an Alternative Therapeutic Target for Epilepsy.
abstract: Epilepsy is one of the most widespread serious neurological disorders, and an aetiological explanation has not been fully identified. In recent decades, a growing body of evidence has highlighted the influential role of autoimmune mechanisms in the progression of epilepsy. The hygiene hypothesis draws people's attention to the association between gut microbes and the onset of multiple immune disorders. It is also believed that, in addition to influencing digestive system function, symbiotic microbiota can bidirectionally and reversibly impact the programming of extraintestinal pathogenic immune responses during autoimmunity. Herein, we investigate the concept that the diversity of parasitifer sensitivity to commensal microbes and the specific constitution of the intestinal microbiota might impact host susceptibility to epilepsy through promotion of Th17 cell populations in the central nervous system (CNS).
authors.affiliation: The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
authors.forename: Jiaying
authors.initials: J
authors.lastname: Wu
authors.affiliation: Ningbo Medical Treatment Center Lihuili Hospital, Ningbo, China.
authors.forename: Yuyu
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
authors.forename: Hongyu
authors.initials: H
authors.lastname: Yang
authors.affiliation: The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
authors.forename: Yuefeng
authors.initials: Y
authors.lastname: Rao
authors.affiliation: The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
authors.forename: Jing
authors.identifier: 0000-0002-4963-5993
authors.initials: J
authors.lastname: Miao
authors.affiliation: The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
authors.forename: Xiaoyang
authors.identifier: 0000-0002-1001-0160
authors.initials: X
authors.lastname: Lu