title: Lower red cell transfusion rates with use of tranexamic acid in single-stage bilateral total knee arthroplasty: A retrospective audit.
abstract: Bilateral total knee arthroplasty (BTKA) patients may require blood transfusion which has its risks. Anti-fibrinolytic drugs such as aprotinin, aminocaproic acid and tranexamic acid (TXA) have reduced transfusion requirements in major surgery. This retrospective audit was performed to assess effectiveness of TXA in reducing blood transfusion rate in single-stage sequential BTKA cases operated by a single surgeon. Records of 91 patients given TXA and 80 controls who were operated before 2012 and not given TXA were reviewed. TXA was given 15mg/kg intravenously (IV) before tourniquet deflation and 3 hours postoperatively.Blood transfusion was done in 9(10%) patients in the TXA group compared to 20(25%)in the control group (p<0.01). One (1.25%) patient in the control group had non-fatal pulmonary embolism.TXA appeared to be effective in decreasing post-operative blood loss and requirement for blood transfusion after single-stage BTKA.
authors.affiliation: Medical College, Department of Surgery, Aga Khan University, Karachi, Pakistan.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Aziz
authors.affiliation: Medical College, Department of Surgery, Aga Khan University, Karachi, Pakistan.
authors.forename: Salman Bin
authors.initials: SB
authors.lastname: Mahmood
authors.affiliation: Section of Orthopedics, Department of Surgery, Aga Khan University, Karachi, Pakistan.
authors.forename: Riaz Hussain
authors.initials: RH
authors.lastname: Lakdawala
authors.affiliation: Section of Orthopedics, Department of Surgery, Aga Khan University, Karachi, Pakistan.
authors.forename: Tashfeen
authors.initials: T
authors.lastname: Ahmad
mesh_terms: D000933:Antifibrinolytic Agents / Q000627:therapeutic use*; D019645:Arthroplasty, Replacement, Knee; D016063:Blood Loss, Surgical; D001803:Blood Transfusion; D006801:Humans; D008485:Medical Audit; D012189:Retrospective Studies; D014148:Tranexamic Acid / Q000627:therapeutic use*
chemical_list: D000933:Antifibrinolytic Agents; D014148:Tranexamic Acid
keywords: Bilateral total knee arthroplasty, Tranexamic acid, Blood loss, Haemoglobin drop, Transfusion.