title: Pharos: Collating protein information to shed light on the druggable genome.
abstract: The 'druggable genome' encompasses several protein families, but only a subset of targets within them have attracted significant research attention and thus have information about them publicly available. The Illuminating the Druggable Genome (IDG) program was initiated in 2014, has the goal of developing experimental techniques and a Knowledge Management Center (KMC) that would collect and organize information about protein targets from four families, representing the most common druggable targets with an emphasis on understudied proteins. Here, we describe two resources developed by the KMC: the Target Central Resource Database (TCRD) which collates many heterogeneous gene/protein datasets and Pharos (https://pharos.nih.gov), a multimodal web interface that presents the data from TCRD. We briefly describe the types and sources of data considered by the KMC and then highlight features of the Pharos interface designed to enable intuitive access to the IDG knowledgebase. The aim of Pharos is to encourage 'serendipitous browsing', whereby related, relevant information is made easily discoverable. We conclude by describing two use cases that highlight the utility of Pharos and TCRD.
authors.affiliation: National Center for Advancing Translational Science, 9800 Medical Center Drive, Rockville, MD 20850, USA.
authors.forename: Dac-Trung
authors.initials: DT
authors.lastname: Nguyen
authors.affiliation: Translational Informatics Division, School of Medicine, University of New Mexico, Albuquerque, NM 87131, USA.
authors.forename: Stephen
authors.initials: S
authors.lastname: Mathias
authors.affiliation: Translational Informatics Division, School of Medicine, University of New Mexico, Albuquerque, NM 87131, USA.
authors.forename: Cristian
authors.initials: C
authors.lastname: Bologa
authors.affiliation: Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
authors.forename: Soren
authors.initials: S
authors.lastname: Brunak
authors.affiliation: Mount Sinai Center for Bioinformatics, Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1603, New York, NY 10029, USA.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Fernandez
authors.affiliation: European Molecular Biology Laboratory - European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK.
authors.forename: Anna
authors.initials: A
authors.lastname: Gaulton
authors.affiliation: European Molecular Biology Laboratory - European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK.
authors.forename: Anne
authors.initials: A
authors.lastname: Hersey
authors.affiliation: Translational Informatics Division, School of Medicine, University of New Mexico, Albuquerque, NM 87131, USA.
authors.forename: Jayme
authors.initials: J
authors.lastname: Holmes
authors.affiliation: Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
authors.forename: Lars Juhl
authors.initials: LJ
authors.lastname: Jensen
authors.affiliation: BenevolentAI, 40 Churchway, London NW1 1LW, UK.
authors.forename: Anneli
authors.initials: A
authors.lastname: Karlsson
authors.affiliation: Translational Informatics Division, School of Medicine, University of New Mexico, Albuquerque, NM 87131, USA.|East China University of Science and Technology, Dept. Pharmaceutical Sciences, Shanghai, China.
authors.forename: Guixia
authors.initials: G
authors.lastname: Liu
authors.affiliation: Mount Sinai Center for Bioinformatics, Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1603, New York, NY 10029, USA.
authors.forename: Avi
authors.initials: A
authors.lastname: Ma'ayan
authors.affiliation: National Center for Advancing Translational Science, 9800 Medical Center Drive, Rockville, MD 20850, USA.
authors.forename: Geetha
authors.initials: G
authors.lastname: Mandava
authors.affiliation: Translational Informatics Division, School of Medicine, University of New Mexico, Albuquerque, NM 87131, USA.
authors.forename: Subramani
authors.initials: S
authors.lastname: Mani
authors.affiliation: Center for Computational Science, University of Miami, Coral Gables, FL 33146, USA.|Department of Applied Chemistry, Delhi Technological University, Delhi 110042, India.
authors.forename: Saurabh
authors.initials: S
authors.lastname: Mehta
authors.affiliation: BenevolentAI, 40 Churchway, London NW1 1LW, UK.
authors.forename: John
authors.initials: J
authors.lastname: Overington
authors.affiliation: Translational Informatics Division, School of Medicine, University of New Mexico, Albuquerque, NM 87131, USA.|BA/MD Program, School of Medicine, University of New Mexico, Albuquerque, NM 87131, USA.
authors.forename: Juhee
authors.initials: J
authors.lastname: Patel
authors.affiliation: Mount Sinai Center for Bioinformatics, Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1603, New York, NY 10029, USA.
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Rouillard
authors.affiliation: Center for Computational Science, University of Miami, Coral Gables, FL 33146, USA.|Department of Molecular and Cellular Pharmacology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.
authors.forename: Stephan
authors.initials: S
authors.lastname: Schürer
authors.affiliation: National Center for Advancing Translational Science, 9800 Medical Center Drive, Rockville, MD 20850, USA.
authors.forename: Timothy
authors.initials: T
authors.lastname: Sheils
authors.affiliation: National Center for Advancing Translational Science, 9800 Medical Center Drive, Rockville, MD 20850, USA.
authors.forename: Anton
authors.initials: A
authors.lastname: Simeonov
authors.affiliation: Translational Informatics Division, School of Medicine, University of New Mexico, Albuquerque, NM 87131, USA.|Center for Molecular Discovery, University of New Mexico Cancer Center, University of New Mexico, Albuquerque, NM 87131, USA.
authors.forename: Larry A
authors.initials: LA
authors.lastname: Sklar
authors.affiliation: National Center for Advancing Translational Science, 9800 Medical Center Drive, Rockville, MD 20850, USA.
authors.forename: Noel
authors.initials: N
authors.lastname: Southall
authors.affiliation: Translational Informatics Division, School of Medicine, University of New Mexico, Albuquerque, NM 87131, USA.
authors.forename: Oleg
authors.initials: O
authors.lastname: Ursu
authors.affiliation: Center for Computational Science, University of Miami, Coral Gables, FL 33146, USA.|Department of Molecular and Cellular Pharmacology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.
authors.forename: Dusica
authors.initials: D
authors.lastname: Vidovic
authors.affiliation: Translational Informatics Division, School of Medicine, University of New Mexico, Albuquerque, NM 87131, USA.|Center for Molecular Discovery, University of New Mexico Cancer Center, University of New Mexico, Albuquerque, NM 87131, USA.
authors.forename: Anna
authors.initials: A
authors.lastname: Waller
authors.affiliation: Translational Informatics Division, School of Medicine, University of New Mexico, Albuquerque, NM 87131, USA.
authors.forename: Jeremy
authors.initials: J
authors.lastname: Yang
authors.affiliation: National Center for Advancing Translational Science, 9800 Medical Center Drive, Rockville, MD 20850, USA.
authors.forename: Ajit
authors.initials: A
authors.lastname: Jadhav
authors.affiliation: Translational Informatics Division, School of Medicine, University of New Mexico, Albuquerque, NM 87131, USA toprea@salud.unm.edu.
authors.forename: Tudor I
authors.initials: TI
authors.lastname: Oprea
authors.affiliation: National Center for Advancing Translational Science, 9800 Medical Center Drive, Rockville, MD 20850, USA guhar@mail.nih.gov.
authors.forename: Rajarshi
authors.initials: R
authors.lastname: Guha
mesh_terms: D016000:Cluster Analysis; D019295:Computational Biology / Q000379:methods; D030541:Databases, Genetic; D055808:Drug Discovery / Q000379:methods; D023281:Genomics / Q000379:methods; D006801:Humans; D009765:Obesity / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism; D010597:Pharmacogenetics / Q000379:methods; D057386:Search Engine; D012984:Software; D064878:Web Browser