title: Impact of hematological inflammatory markers on clinical outcome in patients with salivary duct carcinoma: a multi-institutional study in Japan.
abstract: The prognostic role of modified Glasgow Prognostic Score (mGPS), neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in patients with salivary duct carcinoma (SDC) remains unclear. We conducted a multi-institutional retrospective cohort study of 140 SDC patients. The survival impact of these hematological markers was evaluated using multivariate proportional hazard models.High mGPS (≥1) was significantly associated with worse survival (3-year overall survival (OS): 16.7% vs 66.1%, p-value=0.003; 3-year progression-free survival (PFS): 0.0% vs 27.9%, p-value<0.001). Additionally, high C-reactive protein (CRP) (≥0.39 mg/dl) was significantly associated with worse survival (3-year OS: 32.1% vs 68.2%, p-value=0.001; 3-year PFS: 7.1% vs 31.1%, p-value<0.001). These associations were consistent with multivariate analysis adjusted for established prognostic factors. Although we also found significant association of high NLR (≥2.5) with OS (HR 1.80; 95% confidence interval, 1.05-3.08) in multivariate analysis, this association were inconsistent with the results of PFS. In addition, we found no significant associations of PLR with survival. In conclusion, we found that mGPS, CRP and NLR were identified as prognostic factors associated with survival in SDC patients.
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Kawakita
authors.affiliation: Department of Head and Neck Oncology and Surgery, International University of Health and Welfare Mita Hospital, Tokyo, Japan.
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Tada
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Keio University School of Medicine, Tokyo, Japan.
authors.forename: Yorihisa
authors.initials: Y
authors.lastname: Imanishi
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
authors.forename: Shintaro
authors.initials: S
authors.lastname: Beppu
authors.affiliation: Department of Otolaryngology, Tokyo Medical University School of Medicine, Tokyo, Japan.
authors.forename: Kiyoaki
authors.initials: K
authors.lastname: Tsukahara
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kano
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Keio University School of Medicine, Tokyo, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Ozawa
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Tokai University School of Medicine, Isehara, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Okami
authors.affiliation: Department of Head and Neck Surgery, Niigata Cancer Center Hospital, Niigata, Japan.
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Sato
authors.affiliation: Department of Otolaryngology, Tokyo Medical University School of Medicine, Tokyo, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Shimizu
authors.affiliation: Department of Pathology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan.
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Sato
authors.affiliation: Department of Head and Neck Oncology and Surgery, International University of Health and Welfare Mita Hospital, Tokyo, Japan.
authors.forename: Chihiro
authors.initials: C
authors.lastname: Fushimi
authors.affiliation: Department of Otolaryngology, Tokyo Medical University School of Medicine, Tokyo, Japan.
authors.forename: Soichiro
authors.initials: S
authors.lastname: Takase
authors.affiliation: Department of Head and Neck Oncology and Surgery, International University of Health and Welfare Mita Hospital, Tokyo, Japan.
authors.forename: Takuro
authors.initials: T
authors.lastname: Okada
authors.affiliation: Department of Otolaryngology, Tokyo Medical University School of Medicine, Tokyo, Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Sato
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Keio University School of Medicine, Tokyo, Japan.
authors.forename: Kuninori
authors.initials: K
authors.lastname: Otsuka
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Keio University School of Medicine, Tokyo, Japan.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Watanabe
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Tokai University School of Medicine, Isehara, Japan.
authors.forename: Akihiro
authors.initials: A
authors.lastname: Sakai
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Tokai University School of Medicine, Isehara, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Ebisumoto
authors.affiliation: Department of Head and Neck Surgery, Niigata Cancer Center Hospital, Niigata, Japan.
authors.forename: Takafumi
authors.initials: T
authors.lastname: Togashi
authors.affiliation: Department of Head and Neck Surgery, Niigata Cancer Center Hospital, Niigata, Japan.
authors.forename: Yushi
authors.initials: Y
authors.lastname: Ueki
authors.affiliation: Department of Head and Neck Surgery, Niigata Cancer Center Hospital, Niigata, Japan.
authors.forename: Hisayuki
authors.initials: H
authors.lastname: Ota
authors.affiliation: Department of Anatomic Pathology, Tokyo Medical University School of Medicine, Tokyo, Japan.
authors.forename: Tomotaka
authors.initials: T
authors.lastname: Shimura
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, Chiba University Graduate School of Medicine, Chiba, Japan.
authors.forename: Toyoyuki
authors.initials: T
authors.lastname: Hanazawa
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
authors.forename: Shingo
authors.initials: S
authors.lastname: Murakami
authors.affiliation: Department of Anatomic Pathology, Tokyo Medical University School of Medicine, Tokyo, Japan.
authors.forename: Toshitaka
authors.initials: T
authors.lastname: Nagao
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood*; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D007564:Japan; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D018987:Salivary Ducts / Q000473:pathology*; D012468:Salivary Gland Neoplasms / Q000097:blood* / Q000175:diagnosis / Q000401:mortality* / Q000628:therapy
chemical_list: D015415:Biomarkers; D018836:Inflammation Mediators
keywords: CRP; NLR; mGPS; salivary duct carcinoma; survival