title: Therapeutic Manipulation of Ageing: Repurposing Old Dogs and Discovering New Tricks.
abstract: Ageing is a leading risk factor for many debilitating diseases. While age-related diseases have been the subject of over a century of intense investigation, until recently, physiological ageing was considered unavoidable. Pharmacological and genetic studies have since shown that ageing is a malleable process and that its abrogation can prevent its associated diseases. This review summarises a sample of the most promising efforts to deliver the products of ageing research to the clinic. Current efforts include the use of clinically approved drugs that have since been repurposed, as well as the development of novel therapeutics, to target ageing. Furthermore, ongoing research has sought reliable biomarkers of ageing that will accelerate the development of such therapeutics. Development of these technologies will improve quality of late-life and help relieve the enormous stress placed on state healthcare systems by a rapidly ageing global population. Thus, for both medical and socioeconomic reasons, it is imperative that ageing is made to yield to intervention.
authors.affiliation: Wellcome Trust Centre for Cell-Matrix Research, Division of Cell Matrix Biology and Regenerative Medicine, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PT, United Kingdom.. Electronic address: venkatesh.mallikarjun@postgrad.manchester.ac.uk.
authors.forename: Venkatesh
authors.initials: V
authors.lastname: Mallikarjun
authors.affiliation: Wellcome Trust Centre for Cell-Matrix Research, Division of Cell Matrix Biology and Regenerative Medicine, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PT, United Kingdom.. Electronic address: joe.swift@manchester.ac.uk.
authors.forename: Joe
authors.initials: J
authors.lastname: Swift
mesh_terms: D000375:Aging / Q000187:drug effects* / Q000502:physiology; D000818:Animals; D015415:Biomarkers; D055808:Drug Discovery; D058492:Drug Repositioning; D006801:Humans; D011788:Quality of Life
chemical_list: D015415:Biomarkers
keywords: Ageing; Biomarkers; Clinical trials; Drug repurposing