title: 99mTc-conjugated manganese-based mesoporous silica nanoparticles for SPECT, pH-responsive MRI and anti-cancer drug delivery.
abstract: In recent decades, hybrid imaging techniques that exploit the advantages of multiple imaging technologies have aroused extensive attention due to the deficiencies of single imaging modes. Along with the development of single photon emission computed tomography-magnetic resonance imaging (SPECT-MRI), it is currently necessary to develop a series of dual probes that can combine the outstanding sensitivity of SPECT with the high spatial resolution of MRI. Herein, the commonly used technetium-99 (99mTc) was labelled on the surface of manganese oxide-based mesoporous silica nanoparticles (MnOx-MSNs) for use in SPECT-MRI dual-modal imaging. The radiolabelling yield was as high as 99.1 ± 0.6%, and the r1value of the nanoprobes was able to reach 6.60 mM-1s-1due to the pH-responsive properties of the MnOx-MSNs. The high-performance SPECT-MRI dual-modal imaging was confirmed in vivo in tumour-bearing mice, which could also provide semi-quantitative information for tumour detection. Importantly, these nanoprobes can deliver anti-cancer drugs in cancer therapy due to their unique mesoporous structures. Thus, nanotheranostics combining dual-modal imaging with anti-cancer therapeutic properties were achieved.
authors.affiliation: Department of Radiology, Fudan University Shanghai Cancer Center, Shanghai 200032, China. zhoulp2006@163.com and Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
authors.forename: Hongbo
authors.initials: H
authors.lastname: Gao
authors.affiliation: Department of Radiology, Fudan University Shanghai Cancer Center, Shanghai 200032, China. zhoulp2006@163.com and Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
authors.forename: Xiaohang
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Radiology, Fudan University Shanghai Cancer Center, Shanghai 200032, China. zhoulp2006@163.com and Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Tang
authors.affiliation: Lab of Low-Dimensional Materials Chemistry, Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China.
authors.forename: Dechao
authors.initials: D
authors.lastname: Niu
authors.affiliation: Department of Radiology, Fudan University Shanghai Cancer Center, Shanghai 200032, China. zhoulp2006@163.com and Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
authors.forename: Bingni
authors.initials: B
authors.lastname: Zhou
authors.affiliation: Department of Radiology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Radiology, Fudan University Shanghai Cancer Center, Shanghai 200032, China. zhoulp2006@163.com and Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.affiliation: Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China and Department of Nuclear Medicine, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
authors.forename: Bingxin
authors.initials: B
authors.lastname: Gu
authors.affiliation: The Key Laboratory of Resource Chemistry of Ministry of Education, College of Life and Environmental Science, Shanghai Normal University, Shanghai 200234, China.
authors.forename: Xiaobao
authors.initials: X
authors.lastname: Zhou
authors.affiliation: Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China and Department of Nuclear Medicine, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
authors.forename: Yingying
authors.initials: Y
authors.lastname: Zheng
authors.affiliation: Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China and Department of Nuclear Medicine, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
authors.forename: Yiyun
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Lab of Low-Dimensional Materials Chemistry, Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China.
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Jia
authors.affiliation: Department of Radiology, Fudan University Shanghai Cancer Center, Shanghai 200032, China. zhoulp2006@163.com and Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
authors.forename: Liangping
authors.initials: L
authors.lastname: Zhou
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage; D004337:Drug Carriers; D005260:Female; D008279:Magnetic Resonance Imaging; D008345:Manganese; D051379:Mice; D008807:Mice, Inbred BALB C; D053758:Nanoparticles; D009374:Neoplasms, Experimental / Q000000981:diagnostic imaging; D012822:Silicon Dioxide; D013667:Technetium; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D008345:Manganese; D013667:Technetium; D012822:Silicon Dioxide