title: Phylooncogenomics: Examining the cancer genome in the context of vertebrate evolution.
abstract: Currently, human cancer genomics is making great progress, and many mutations of new cancer driver genes have been detected at an unprecedented rate in a variety of human cancers. Many details of the genetic alterations in cancer cell genomes have been revealed by the massively parallel sequencing. Long-lasting aneuploidy caused large-scale somatic copy number alterations remains a difficulty as there are too many genes located on such big chromosomal fragments, and this cannot simply be solved by increasing sequencing depth and tumor sample numbers. Comparative oncogenomics may provide us with a solution to this problem. Here, we review some of the common animal cancer models and propose to analyze cancer cell genomics in vertebrate phylogenetic backgrounds. Thus phylooncogenomics may provide us with a unique perspective on he nature of cancer biology unattainable by single species studies.
authors.affiliation: Department of Comparative Pathobiology, Purdue University, College of Veterinary Medicine, United States; Purdue University Center for Cancer Research, United States.
authors.forename: GuangJun
authors.initials: G
authors.lastname: Zhang
authors.affiliation: Department of Comparative Pathobiology, Purdue University, College of Veterinary Medicine, United States.
authors.forename: Tracy H
authors.initials: TH
authors.lastname: Vemulapalli
authors.affiliation: Purdue University Center for Cancer Research, United States; Department of Basic Medical Sciences, Purdue University, College of Veterinary Medicine, United States.
authors.forename: Jer-Yen
authors.initials: JY
authors.lastname: Yang
keywords: Cancer genome; Comparative oncogenomics; Copy number alterations; Evolution; Phylooncogenomics; Vertebrate