title: Long-range, wide-field swept-source optical coherence tomography with GPU accelerated digital lock-in Doppler vibrography for real-time,in vivomiddle ear diagnostics.
abstract: We present the design, implementation and validation of a swept-source optical coherence tomography (OCT) system for real-time imaging of the human middle ear in live patients. Our system consists of a highly phase-stable Vernier-tuned distributed Bragg-reflector laser along with a real-time processing engine implemented on a graphics processing unit. We use the system to demonstrate, for the first time in live subjects, real-time Doppler measurements of middle ear vibration in response to sound, video rate 2D B-mode imaging of the middle ear and 3D volumetric B-mode imaging. All measurements were performed non-invasively through the intact tympanic membrane demonstrating that the technology is readily translatable to the clinic.
authors.affiliation: School of Biomedical Engineering, Dalhousie University, 5981 University Ave, Halifax NS, B3H4R2, Canada.
authors.forename: Dan
authors.initials: D
authors.lastname: MacDougall
authors.affiliation: School of Biomedical Engineering, Dalhousie University, 5981 University Ave, Halifax NS, B3H4R2, Canada.
authors.forename: Joshua
authors.initials: J
authors.lastname: Farrell
authors.affiliation: School of Biomedical Engineering, Dalhousie University, 5981 University Ave, Halifax NS, B3H4R2, Canada; Department of Electrical and Computer Engineering, Dalhousie University, 1459 Oxford St, Halifax NS, B3H4R2, Canada.
authors.forename: Jeremy
authors.initials: J
authors.lastname: Brown
authors.affiliation: School of Biomedical Engineering, Dalhousie University, 5981 University Ave, Halifax NS, B3H4R2, Canada; Department of Surgery, Dalhousie University, 1276 South Park St, Halifax NS, B3H2Y9, Canada.
authors.forename: Manohar
authors.initials: M
authors.lastname: Bance
authors.affiliation: School of Biomedical Engineering, Dalhousie University, 5981 University Ave, Halifax NS, B3H4R2, Canada; Department of Electrical and Computer Engineering, Dalhousie University, 1459 Oxford St, Halifax NS, B3H4R2, Canada.
authors.forename: Robert
authors.initials: R
authors.lastname: Adamson
keywords: (170.2655) Functional monitoring and imaging; (170.3880) Medical and biological imaging; (170.4500) Optical coherence tomography; (170.4940) Otolaryngology