title: Non-Invasive Glucose Measurement by Use of Metabolic Heat Conformation Method.
abstract: A non-invasive glucose measurement system based on the method of metabolic heat conformation (MHC) is presented in this paper. This system consists of three temperature sensors, two humidity sensors, an infrared sensor and an optical measurement device. The glucose level can be deduced from the quantity of heat dissipation, blood flow rate of local tissue and degree of blood oxygen saturation. The methodology of the data process and the measurement error are also analyzed. The system is applied in a primary clinical test. Compared with the results of a commercial automated chemistry analyzer, the correlation coefficient of the collected data from the system is 0.856. Result shows that the correlation coefficient improves when the factor of heat dissipated by evaporation of the skin is added in. A non-invasive method of measuring the blood flow rate of local tissue by heat transmission between skin and contacted conductor is also introduced. Theoretical derivation and numerical simulation are completed as well. The so-called normalized difference mean (NDM) is chosen to express the quantity of the blood flow rate. The correlation coefficient between the blood flow rates by this method and the results of a Doppler blood flow meter is equal to 0.914.
authors.affiliation: State Key Laboratory of Precision Measurement Technology and Instruments, Department of Precision Instruments and Mechanology, Tsinghua University, Beijing 100084, People's Republic of China. tangf@mail.tsinghua.edu.cn.
authors.forename: Fei
authors.initials: F
authors.lastname: Tang
authors.affiliation: State Key Laboratory of Precision Measurement Technology and Instruments, Department of Precision Instruments and Mechanology, Tsinghua University, Beijing 100084, People's Republic of China.
authors.forename: Xiaohao
authors.initials: X
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Precision Measurement Technology and Instruments, Department of Precision Instruments and Mechanology, Tsinghua University, Beijing 100084, People's Republic of China.
authors.forename: Dongsheng
authors.initials: D
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Precision Measurement Technology and Instruments, Department of Precision Instruments and Mechanology, Tsinghua University, Beijing 100084, People's Republic of China.
authors.forename: Junfeng
authors.initials: J
authors.lastname: Li
keywords: blood flow rate; degree of blood oxygen saturation; evaporation; heat dissipation; sensor