title: Pregnancy and cesarean delivery after multimodal therapy for vulvar carcinoma: A case report.
abstract: Reports of pregnancy following treatment for vulvar carcinoma are extremely uncommon, as the main problem of subsequent pregnancy is vulvar scarring following radical surgery. We herein report the case of a patient who was diagnosed with stage I squamous cell carcinoma of the vulva at the age of 17 years and was treated with multimodal therapy, including neoadjuvant chemotherapy, wide local excision with bilateral inguinal lymph node dissection and adjuvant radiotherapy. The patient became pregnant spontaneously 9 years after her initial diagnosis and the antenatal course was good, except for mild acute pyelonephritis at 25 weeks of gestation. An elective caesarean section was performed at 38 weeks of gestation due to vulvar scarring following multimodal therapy, particularly radiotherapy. The patient remains alive and well, without signs of recurrence or metastasis 12 years after her diagnosis and treatment. Radical vulvectomy as well as multimodal therapy for vulvar carcinoma, particularly radiotherapy, may cause extensive skin scarring. The presence of vulvar scarring following multimodal therapy for vulvar carcinoma may increase the incidence of caesarean delivery.
authors.affiliation: Department of Obstetrics and Gynecology, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan; Department of Obstetrics and Gynecology, Mie Prefectural General Medical Center, Yokkaichi, Mie 510-8561, Japan.
authors.forename: Kuniaki
authors.initials: K
authors.lastname: Toriyabe
authors.affiliation: Department of Obstetrics and Gynecology, Mie Prefectural General Medical Center, Yokkaichi, Mie 510-8561, Japan.
authors.forename: Haruki
authors.initials: H
authors.lastname: Taniguchi
authors.affiliation: Department of Obstetrics and Gynecology, Mie Prefectural General Medical Center, Yokkaichi, Mie 510-8561, Japan; Department of Obstetrics and Gynecology, Kinan Hospital, Mihama, Mie 519-5293, Japan.
authors.forename: Tokihiro
authors.initials: T
authors.lastname: Senda
authors.affiliation: Department of Obstetrics and Gynecology, Mie Prefectural General Medical Center, Yokkaichi, Mie 510-8561, Japan.
authors.forename: Masako
authors.initials: M
authors.lastname: Nakano
authors.affiliation: Department of Obstetrics and Gynecology, Mie Prefectural General Medical Center, Yokkaichi, Mie 510-8561, Japan.
authors.forename: Yoshinari
authors.initials: Y
authors.lastname: Kobayashi
authors.affiliation: Department of Obstetrics and Gynecology, Mie Prefectural General Medical Center, Yokkaichi, Mie 510-8561, Japan.
authors.forename: Miho
authors.initials: M
authors.lastname: Izawa
authors.affiliation: Department of Obstetrics and Gynecology, Mie Prefectural General Medical Center, Yokkaichi, Mie 510-8561, Japan.
authors.forename: Hirohiko
authors.initials: H
authors.lastname: Tanaka
authors.affiliation: Department of Obstetrics and Gynecology, Mie Prefectural General Medical Center, Yokkaichi, Mie 510-8561, Japan.
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Asakura
authors.affiliation: Department of Obstetrics and Gynecology, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan.
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Tabata
authors.affiliation: Department of Obstetrics and Gynecology, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan.
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Ikeda
keywords: caesarean delivery; multimodal therapy; pregnancy; squamous cell carcinoma; vulvar carcinoma