title: The Expanding World of Small Molecule Microarrays.
abstract: Speed and throughput are vital ingredients for discovery driven, "-omics" research. The small molecule microarray (SMM) succeeds at delivering phenomenal screening throughput and versatility. The concept at the heart of the technology is elegant, yet simple: by presenting large collections of molecules in high density on a flat surface, one is able to interrogate all possible interactions with desired targets, in just a single step. SMMs have become established as the choice platform for screening, lead discovery, and molecular characterization. This introduction describes the principles governing microarray construction and use, focusing on practical challenges faced when conducting SMM experiments. It will explain the key design considerations and lay the foundation for the chapters that follow. (An earlier version of this chapter appeared in Small Molecule Microarrays: Methods and Protocols, published in 2010.).
authors.affiliation: Defence Medical and Environmental Research Institute, DMERI, DSO National Laboratories, #09-01, 27 Medical Drive, Singapore, Singapore, 117510. mahesh@dso.org.sg.|Department of Chemistry, Faculty of Science, National University of Singapore, 3 Science Drive 3, Singapore, Singapore, 117543. mahesh@dso.org.sg.
authors.forename: Mahesh
authors.initials: M
authors.lastname: Uttamchandani
authors.affiliation: Department of Chemistry, Faculty of Science, National University of Singapore, 3 Science Drive 3, Singapore, Singapore, 117543. chmyaosq@nus.edu.sg.
authors.forename: Shao Q
authors.initials: SQ
authors.lastname: Yao
mesh_terms: D046228:Microarray Analysis / Q000379:methods*; D054852:Small Molecule Libraries / Q000032:analysis*
chemical_list: D054852:Small Molecule Libraries
keywords: Combinatorial chemistry; Drug discovery; Enzyme profiling; Glycomics; High-throughput screening; Ligand discovery; Proteomics; Sero-profiling; Small molecule microarrays; Solid-phase synthesis