title: ACUTE VISION LOSS AS THE ONLY SIGN OF LEUKEMIA RELAPSE.
abstract: OBJECTIVE
  To report a case of unilateral exudative retinal detachment as the sole presentation of relapsing B-type lymphoblastic leukemia in a 35-year-old man after 3 years of remission.
  
  
  METHODS
  Case report.
  
  
  RESULTS
  A 35-year-old man in complete remission of high-risk type B acute lymphoblastic leukemia (ALL-B) presented with acute vision loss in his left eye. Exudative retinal detachment was diagnosed at initial evaluation. Hematological and ocular studies were performed. Although there was no evidence of blood, cerebrospinal fluid, or bone marrow disease relapse, transvitreal retinochoroidal cytology identified the infiltration of lymphoblastic leukemic B cells with t(12:21) translocation as the only sign of relapsing ALL-B.
  
  
  CONCLUSIONS
  At first sign of vision loss or ocular symptoms in a patient with a history of lymphoblastic leukemia, and regardless of the hematological findings, exhaustive ophthalmologic exploration and ocular biopsy should be performed without delay-this being crucial for clinical decision making because a prompt diagnosis improves the chances of survival.
authors.affiliation: Department of Ophthalmology, Valencia University Clinic Hospital, Valencia, Spain.
authors.forename: Marta
authors.initials: M
authors.lastname: Cerdà-Ibáñez
authors.affiliation: Department of Ophthalmology, Valencia University Clinic Hospital, Valencia, Spain.
authors.forename: Patricia
authors.initials: P
authors.lastname: Bayo-Calduch
authors.affiliation: Department of Ophthalmology, Valencia University Clinic Hospital, Valencia, Spain.
authors.forename: Laura
authors.initials: L
authors.lastname: Manfreda-Domínguez
authors.affiliation: Department of Ophthalmology, Valencia University Clinic Hospital, Valencia, Spain.|Department of Medicine, University of Valencia, Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: Duch-Samper
mesh_terms: D000208:Acute Disease; D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001706:Biopsy; D001766:Blindness / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D058450:Endotamponade; D005434:Flow Cytometry; D006801:Humans; D056965:Injections, Intraocular; D008279:Magnetic Resonance Imaging; D008297:Male; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D012008:Recurrence; D012163:Retinal Detachment / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D012827:Silicone Oils / Q000008:administration & dosage; D014792:Visual Acuity; D014821:Vitrectomy
chemical_list: D000970:Antineoplastic Agents; D012827:Silicone Oils