title: The Investigation of Risk Factors Impacting Breast Cancer in Guilan Province
abstract: Introduction: Breast cancer is multifactorial therefore more recognition of risk factors is important in its prevention.
  Objective: This study was conducted in order to determine the factors influencing breast cancer in women referred to
  health centers in Guilan province in 2015-2016. Method: In a case- control study, 225 women with breast cancer were
  investigated. The control group consisted of 225 healthy women of the relatives (third-rank) whose phone numbers were
  obtained from the patients. Data were collected through telephone interviews. Results: The risk of breast cancer raised
  in women who have a family history of other cancers (OR= 3.5; 95% CI= 1.96-6.6) ,exposure to X-Ray (OR= 2.5; 95%
  CI=1.1-5.5), having more than 4 children (OR= 2.695% CI=1.2-4.8), age more than 36 years at first pregnancy(OR=2.3;
  95% CI=0.7-5.1),primary level of education (OR= 5.4;95% CI=2.8-11.2) and inadequate intake of fruit (OR=1.5; 95%
  CI=1-2.2). Also, presence of the following factors reduced breast cancer risk: regular menstruation (OR= 0.66; CI=0.4-
  0.9), duration of breastfeeding more than 12 months, less than 6 months and 7-12 months (OR=0.23; 95% CI=0.09-0.59
  , OR=0.29; 95% CI=0.17-0.49 and OR=0.03; 95% CI=0.01-0.08) and parity (OR=0.4; 95% CI=0.27-0.83) In multiple
  linear regression analysis of higher education (OR=0.16; 95% CI=0.03-0.77), using contraceptives for more than 16
  years (OR=2.3; 95% CI=1.4-3.9), family history of other cancers (OR=6.1; 95% CI=1.9-19.3) and a history of X-Ray
  exposure (OR=4.4; 95% CI=1.07-18.1) were considered as predictive factors. Conclusion: The results of this study
  emphasize the importance of informing women about breast cancer risk factors. So, identification of these risk factors
  is required as important means of prevention and treatment of breast cancer.
authors.affiliation: Social Determinants of Health Research Center (SDHRC),Guilan University of Medical Sciences,
  Rasht, Iran. Email: atrkarroushan@gmail.com
authors.forename: Farahnaz
authors.initials: F
authors.lastname: Joukar
authors.forename: Zahra
authors.initials: Z
authors.lastname: Ahmadnia
authors.forename: Zahra
authors.initials: Z
authors.lastname: Atrkar-Roushan
authors.forename: Farideh
authors.initials: F
authors.lastname: Hasavari
authors.forename: Abbas
authors.initials: A
authors.lastname: Rahimi
keywords: Prevention; risk factors; breast cancer; case-control studies; Iran