title: Aberrations in the Iron Regulatory Gene Signature Are Associated with Decreased Survival in Diffuse Infiltrating Gliomas.
abstract: Iron is a tightly regulated micronutrient with no physiologic means of elimination and is necessary for cell division in normal tissue. Recent evidence suggests that dysregulation of iron regulatory proteins may play a role in cancer pathophysiology. We use public data from The Cancer Genome Atlas (TCGA) to study the association between survival and expression levels of 61 genes coding for iron regulatory proteins in patients with World Health Organization Grade II-III gliomas. Using a feature selection algorithm we identified a novel, optimized subset of eight iron regulatory genes (STEAP3, HFE, TMPRSS6, SFXN1, TFRC, UROS, SLC11A2, and STEAP4) whose differential expression defines two phenotypic groups with median survival differences of 52.3 months for patients with grade II gliomas (25.9 vs. 78.2 months, p< 10-3), 43.5 months for patients with grade III gliomas (43.9 vs. 87.4 months, p = 0.025), and 54.0 months when considering both grade II and III gliomas (79.9 vs. 25.9 months, p < 10-5).
authors.affiliation: College of Medicine. Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania, United States of America.
authors.forename: Cody
authors.initials: C
authors.lastname: Weston
authors.affiliation: Department of Data Science. Geisinger Medical Center, Danville, Pennsylvania, United States of America.
authors.forename: Joe
authors.identifier: http://orcid.org/0000-0002-2797-9664
authors.initials: J
authors.lastname: Klobusicky
authors.affiliation: Department of Public Health Sciences. Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania, United States of America.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Weston
authors.affiliation: College of Medicine. Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania, United States of America.
authors.forename: James
authors.initials: J
authors.lastname: Connor
authors.affiliation: Department of Neurosurgery. Geisinger Medical Center, Danville, Pennsylvania, United States of America.
authors.forename: Steven A
authors.initials: SA
authors.lastname: Toms
authors.affiliation: Department of Neurosurgery. Geisinger Medical Center, Danville, Pennsylvania, United States of America.|Department of Surgery. Pennsylvania State School of Medicine, Danville, Pennsylvania, United States of America.
authors.forename: Nicholas F
authors.initials: NF
authors.lastname: Marko
mesh_terms: D004058:Diffusion; D023281:Genomics; D005910:Glioma / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D007501:Iron / Q000378:metabolism*; D053208:Kaplan-Meier Estimate; D008297:Male; D012189:Retrospective Studies; D059467:Transcriptome
chemical_list: D007501:Iron