title: Linear Folliculotropic CD30-Positive Lymphomatoid Drug Reaction.
abstract: We report a unique case of probable drug-induced CD30-positive lymphomatoid reaction. A 58-year-old woman presented with bilateral facial eruptions of 3 weeks duration composed of erythematosus papules in a linear distribution. The pathological features demonstrated a dense dermal and follicular infiltrate of many medium- to large-sized atypical CD30-positive lymphoid cells. The rash resolved rapidly after discontinuation of her medication 1 week later and did not recur. This case highlights the importance of clinicopathological correlation.
authors.affiliation: *Department of Dermatology, Mackay Memorial Hospital, Taipei, Taiwan; and †Department of Medicine, Mackay Medical College, New Taipei City, Taiwan.
authors.forename: Yi-Chin
authors.initials: YC
authors.lastname: Chen
authors.forename: Yu-Hung
authors.initials: YH
authors.lastname: Wu
mesh_terms: D001707:Biopsy, Needle; D003937:Diagnosis, Differential; D064420:Drug-Related Side Effects and Adverse Reactions / Q000175:diagnosis / Q000473:pathology*; D005148:Facial Dermatoses / Q000175:diagnosis / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D017730:Ki-1 Antigen / Q000276:immunology*; D008214:Lymphocytes / Q000473:pathology; D016410:Lymphoma, T-Cell, Cutaneous / Q000139:chemically induced* / Q000175:diagnosis; D008875:Middle Aged; D010080:Oxazoles / Q000009:adverse effects* / Q000627:therapeutic use; D018570:Risk Assessment; D012878:Skin Neoplasms / Q000139:chemically induced* / Q000175:diagnosis; D028761:Withholding Treatment
chemical_list: D017730:Ki-1 Antigen; D010080:Oxazoles; C100282:mephenoxalone