title: Intravitreal infusion: A novel approach for intraocular drug delivery.
abstract: Intraocular injection has become an increasingly important intervention in the treatment of posterior segment diseases. However, an acute intraocular pressure (IOP) elevation after intravitreal injection is a common concern. This study aimed to evaluate the efficacy of intravitreal infusion in maintaining stable IOP in a rabbit model. Trypan blue (TB) 0.06% with an external pump was used to evaluate intravitreal infusion in rabbit eyes. Groups A (50 μL), B (100 μL), C (150 μL), and D (200 μL) were slowly infused over 30 minutes with TB. As a control, Group E underwent conventional intravitreal injection of 100 μL of TB. Group F received a bolus infusion of 100 μL of TB within 1 minute. The mean increases in IOP during infusion for each group were: Group A (7.93 ± 3.80 mmHg), B (13.97 ± 3.17 mmHg), C (19.91 ± 6.06 mmHg) and D (29.38 ± 8.97 mmHg). Immediately post-injection in group E the mean increase in IOP amounted to 34.33 ± 6.57 mmHg. The mean increase in IOP of group F after bolus infusion was 49.89 ± 1.71 mmHg. Intravitreal infusion maintains a stable IOP and provides a controlled infusion speed compared with intravitreal injection.
authors.affiliation: Department of Ophthalmology and Centre of Eye Research, The Second Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Jiao
authors.initials: J
authors.lastname: Tian
authors.affiliation: Department of Ophthalmology and Centre of Eye Research, The Second Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Ophthalmology and Centre of Eye Research, The Second Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Ophthalmology and Centre of Eye Research, The Second Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Yangyan
authors.initials: Y
authors.lastname: Xiao
authors.affiliation: Department of Ophthalmology and Centre of Eye Research, The Second Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Luosheng
authors.initials: L
authors.lastname: Tang
mesh_terms: D000818:Animals; D016503:Drug Delivery Systems; D005123:Eye / Q000187:drug effects; D007429:Intraocular Pressure; D058449:Intravitreal Injections; D011817:Rabbits; D014343:Trypan Blue / Q000008:administration & dosage / Q000494:pharmacology
chemical_list: D014343:Trypan Blue