title: Self and other body perception in anorexia nervosa: The role of posterior DMN nodes.
abstract: Body image distortion is a core symptom of anorexia nervosa (AN), which involves alterations in self- (and other's) evaluative processes arising during body perception. At a neural level, self-related information is thought to rely on areas of the so-called default mode network (DMN), which, additionally, shows prominent synchronised activity at rest.
  
  
  
  Twenty female patients with AN and 20 matched healthy controls were scanned using magnetic resonance imaging when: (a) viewing video clips of their own body and another's body; (b) at rest. Between-group differences within the DMN during task performance were evaluated and further explored for task-related and resting-state-related functional connectivity alterations.
  
  
  
  AN patients showed a hyperactivation of the dorsal posterior cingulate cortex during their own-body processing but a response failure to another's body processing at the precuneus and ventral PCC. Increased task-related connectivity was found between dPCC-dorsal anterior cingulate cortex and precuneus-mid-temporal cortex. Further, AN patients showed decreased resting-state connectivity between the dPCC and the angular gyrus.
  
  
  
  The PCC and the precuneus are suggested as key components of a network supporting self-other-evaluative processes implicated in body distortion, while the existence of DMN alterations at rest might reflect a sustained, task-independent breakdown within this network in AN.
authors.affiliation: a Bellvitge University Hospital - Institut d'Investigació Biomèdica de Bellvitge (IDIBELL) , Barcelona , Spain.|b Department of Clinical Sciences , School of Medicine, University of Barcelona , Barcelona , Spain.|c Melbourne Neuropsychiatry Centre, The Department of Psychiatry , The University of Melbourne , Melbourne , Australia.|d Depression and Anxiety Program, Mental Health Department , Parc Taulí Sabadell University Hospital , Barcelona , Spain.
authors.forename: Esther
authors.initials: E
authors.lastname: Via
authors.affiliation: a Bellvitge University Hospital - Institut d'Investigació Biomèdica de Bellvitge (IDIBELL) , Barcelona , Spain.|d Depression and Anxiety Program, Mental Health Department , Parc Taulí Sabadell University Hospital , Barcelona , Spain.|e CIBER Salud Mental (CIBERSAM) , Instituto de Salud Carlos III , Barcelona , Spain.
authors.forename: Ximena
authors.initials: X
authors.lastname: Goldberg
authors.affiliation: a Bellvitge University Hospital - Institut d'Investigació Biomèdica de Bellvitge (IDIBELL) , Barcelona , Spain.
authors.forename: Isabel
authors.initials: I
authors.lastname: Sánchez
authors.affiliation: f Clinical research group in human pharmacology and neuroscience , IMIM Research Institute at the Hospital de Mar , Barcelona , Spain.|g CIBER Fisiopatología Obesidad y Nutrición (CIBERObn) , Instituto de Salud Carlos III , Barcelona , Spain.
authors.forename: Laura
authors.initials: L
authors.lastname: Forcano
authors.affiliation: c Melbourne Neuropsychiatry Centre, The Department of Psychiatry , The University of Melbourne , Melbourne , Australia.
authors.forename: Ben J
authors.initials: BJ
authors.lastname: Harrison
authors.affiliation: c Melbourne Neuropsychiatry Centre, The Department of Psychiatry , The University of Melbourne , Melbourne , Australia.|h Orygen, The National Centre of Excellence in Youth Mental Health , Melbourne , Australia.
authors.forename: Christopher G
authors.initials: CG
authors.lastname: Davey
authors.affiliation: i MRI Research Unit , Hospital del Mar, CIBERSAM G21 , Barcelona , Spain.
authors.forename: Jesús
authors.initials: J
authors.lastname: Pujol
authors.affiliation: a Bellvitge University Hospital - Institut d'Investigació Biomèdica de Bellvitge (IDIBELL) , Barcelona , Spain.
authors.forename: Ignacio
authors.initials: I
authors.lastname: Martínez-Zalacaín
authors.affiliation: a Bellvitge University Hospital - Institut d'Investigació Biomèdica de Bellvitge (IDIBELL) , Barcelona , Spain.|b Department of Clinical Sciences , School of Medicine, University of Barcelona , Barcelona , Spain.|g CIBER Fisiopatología Obesidad y Nutrición (CIBERObn) , Instituto de Salud Carlos III , Barcelona , Spain.
authors.forename: Fernando
authors.initials: F
authors.lastname: Fernández-Aranda
authors.affiliation: a Bellvitge University Hospital - Institut d'Investigació Biomèdica de Bellvitge (IDIBELL) , Barcelona , Spain.|e CIBER Salud Mental (CIBERSAM) , Instituto de Salud Carlos III , Barcelona , Spain.|j Department of Psychobiology and Methodology in Health Sciences , Universitat Autònoma de Barcelona , Spain.
authors.forename: Carles
authors.initials: C
authors.lastname: Soriano-Mas
authors.affiliation: d Depression and Anxiety Program, Mental Health Department , Parc Taulí Sabadell University Hospital , Barcelona , Spain.|k Department of Psychiatry , Universitat Autònoma de Barcelona , Spain.
authors.forename: Narcís
authors.initials: N
authors.lastname: Cardoner
authors.affiliation: a Bellvitge University Hospital - Institut d'Investigació Biomèdica de Bellvitge (IDIBELL) , Barcelona , Spain.|b Department of Clinical Sciences , School of Medicine, University of Barcelona , Barcelona , Spain.|e CIBER Salud Mental (CIBERSAM) , Instituto de Salud Carlos III , Barcelona , Spain.
authors.forename: José M
authors.initials: JM
authors.lastname: Menchón
mesh_terms: D000328:Adult; D000856:Anorexia Nervosa / Q000000981:diagnostic imaging / Q000503:physiopathology*; D001828:Body Image; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000503:physiopathology*; D063132:Connectome / Q000379:methods*; D005260:Female; D006179:Gyrus Cinguli / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D009415:Nerve Net / Q000000981:diagnostic imaging / Q000503:physiopathology*; D012649:Self Concept; D014796:Visual Perception / Q000502:physiology*; D055815:Young Adult
keywords: Anorexia nervosa; body image; fMRI; resting state; self-evaluation