title: Frequency of 3' VNTR Polymorphism in the Dopamine Transporter Gene SLC6A3 in Humans Predisposed to Antisocial Behavior.
abstract: Predisposition to antisocial behavior can be related to the presence of certain polymorphic variants of genes encoding dopaminergic system proteins. We studied the frequencies of allele variants and genotypes of variable number tandem repeat polymorphism in 3' untranslated region (3' VTNR) of the dopaminergic transporter SLC6A3 gene in Caucasian men committed socially dangerous violent and non-violent crimes. Alleles with 9 and 10 repeats were most frequent in both the control group and group of men predisposed to antisocial behavior. At the same time, the 10/10 genotype was more frequently observed in the group of men prone to antisocial non-violent behavior. Hence, the presence of certain variants of 3' VTNR polymorphism of SLC6A3 gene in men is associated with predisposition to certain forms of antisocial behavior.
authors.affiliation: Research Institute of Physiology and Fundamental Medicine, Novosibirsk, Russia. india06@mail.ru.
authors.forename: E V
authors.initials: EV
authors.lastname: Cherepkova
authors.affiliation: Research Institute of Physiology and Fundamental Medicine, Novosibirsk, Russia.
authors.forename: L I
authors.initials: LI
authors.lastname: Aftanas
authors.affiliation: Research Institute of Therapy and Preventive Medicine, Novosibirsk, Russia.|Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
authors.forename: N
authors.initials: N
authors.lastname: Maksimov
authors.affiliation: Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.|Novosibirsk State University, Novosibirsk, Russia.
authors.forename: P N
authors.initials: PN
authors.lastname: Menshanov
mesh_terms: D020413:3' Untranslated Regions; D000328:Adult; D000483:Alleles; D000987:Antisocial Personality Disorder / Q000175:diagnosis / Q000235:genetics* / Q000523:psychology; D016022:Case-Control Studies; D050483:Dopamine Plasma Membrane Transport Proteins / Q000235:genetics*; D005607:Fraud / Q000523:psychology; D015870:Gene Expression; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006708:Homicide / Q000523:psychology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011329:Prisoners / Q000523:psychology*; D012426:Russia; D020080:Tandem Repeat Sequences; D013800:Theft / Q000523:psychology; D044465:White People
chemical_list: D020413:3' Untranslated Regions; D050483:Dopamine Plasma Membrane Transport Proteins; C493214:SLC6A3 protein, human
keywords: 3’ VNTR polymorphism; SLC6A3; antisocial behavior; case–control study; dopamine transporter