title: Serum luteinizing hormone level on the third day after ovarian stimulation in GnRH agonist short protocol is predictive of outcome in poor responders but not in normal responders.
abstract: OBJECTIVE
  To identify whether prognostic value of LH measurement in normal responders (NR) is different from poor responders (POR).
  
  
  METHODS
  A retrospective, single-center study was conducted among patients who underwent ovarian stimulation with short protocol, with 300 NR and 101 POR, according to Bologna Consensus criteria. LH was measured on 3rd and 5th day after stimulation and HCG administration day.
  
  
  RESULTS
  There was significant difference in the clinical pregnancy rate per cycle initiated among those with LH level on the third day after stimulation (a) below the 25 centile (b) between the 25 and 75 centile and (c) above the 75 centile in women with POR (7.7%, 15.1% vs. 36.4%, p = 0.02) but not in NR. There was significant correlation between LH ranks and clinical pregnancy rate in POR (p = 0.02) but not in NR. Factors associated with clinical pregnancy rate in POR were age and LH on the third of stimulation, while factors in NR were age, AFC and FSH.
  
  
  CONCLUSIONS
  LH level on the 3rd day of stimulation was predictive of clinical pregnancy in POR but not in NR.
authors.affiliation: a Medical Center for Human Reproduction, Beijing Chao-Yang Hospital, Capital Medical University , Beijing , People's Republic of China.|b Department of Obstetrics and Gynecology , Fuxing Hospital, Capital Medical University , Beijing , People's Republic of China.
authors.forename: Hai-Yan
authors.initials: HY
authors.lastname: Zhu
authors.affiliation: a Medical Center for Human Reproduction, Beijing Chao-Yang Hospital, Capital Medical University , Beijing , People's Republic of China.
authors.forename: Shan
authors.initials: S
authors.lastname: Liu
authors.affiliation: c School of Public Health, Capital Medical University , Beijing , China , and.
authors.forename: Dian
authors.initials: D
authors.lastname: He
authors.affiliation: a Medical Center for Human Reproduction, Beijing Chao-Yang Hospital, Capital Medical University , Beijing , People's Republic of China.
authors.forename: Wen-Hui
authors.initials: WH
authors.lastname: Zhou
authors.affiliation: d Reproductive Medicine and Surgery Unit, Prince of Wales Hospital, Chinese University of Hong Kong , Hong Kong , People's Republic of China.
authors.forename: Tin-Chiu
authors.initials: TC
authors.lastname: Li
authors.affiliation: a Medical Center for Human Reproduction, Beijing Chao-Yang Hospital, Capital Medical University , Beijing , People's Republic of China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Li
mesh_terms: D000328:Adult; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists*; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood*; D017063:Outcome Assessment, Health Care; D010062:Ovulation Induction / Q000379:methods*; D011247:Pregnancy; D018873:Pregnancy Rate; D011379:Prognosis; D013997:Time Factors
chemical_list: D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone
keywords: GnRH agonist; in vitro fertilization; luteinizing hormone; poor responder