title: Determination of Lamotrigine in Pharmaceutical Preparations by Adsorptive Stripping Voltammetry Using Screen Printed Electrodes.
abstract: This paper describes a procedure that has been optimized for the determination of lamotrigine by Differential Pulse Adsorptive Stripping Voltammetry (DPAdSV) using carbon screen-printed electrodes (CSPE) and mercury coated carbon screen-printed electrodes. Selection of the experimental parameters was made using experimental design methodology. The detection limit found was 5.0 x 10-6M and 2.0 x 10-6M for the non modified and Hg modified CSPE, respectively. In terms of reproducibility, the precision of the above mentioned methods was calculated in %RSD values at 9.83% for CSPE and 2.73% for Hg-CSPE. The Hg-coated CSPEs developed in this work were successfully applied in the determination of lamotrigine in pharmaceutical preparations.
authors.affiliation: Departamento de Química, Área de Química Analítica, Facultad de Ciencias, Universidad de Burgos, Plaza Misael Bañuelos s/n, E-09001 Burgos, Spain. olgado@ubu.es.
authors.forename: Olga
authors.initials: O
authors.lastname: Domínguez-Renedo
authors.affiliation: Departamento de Química, Área de Química Analítica, Facultad de Ciencias, Universidad de Burgos, Plaza Misael Bañuelos s/n, E-09001 Burgos, Spain. meburgoa@ubu.es.
authors.forename: M Encarnación Burgoa
authors.initials: ME
authors.lastname: Calvo
authors.affiliation: Departamento de Química, Área de Química Analítica, Facultad de Ciencias, Universidad de Burgos, Plaza Misael Bañuelos s/n, E-09001 Burgos, Spain. jarcos@ubu.es.
authors.forename: M Julia
authors.initials: MJ
authors.lastname: Arcos-Martínez
keywords: differential pulse adsorptive stripping voltammetry.; lamotrigine; screen-printed electrodes