title: INSIG2 polymorphism and weight gain, dyslipidemia and serum adiponectin in Finnish patients with schizophrenia treated with clozapine.
abstract: OBJECTIVE
  To investigate INSIG2's association with obesity, weight change and serum lipid profile during clozapine treatment.
  
  
  METHODS
  Subjects with schizophrenia (n = 190) were genotyped, identifying seven SNPs. Genetic risk scores (GRSs) were calculated to adiponectin, high-density lipoprotein cholesterol, triglycerides and weight gain.
  
  
  RESULTS
  In the model for weight gain, SNPs rs12151787, rs17047733 and rs10490626 were selected. Explanatory variables were BMI (p = 5.05 × 10-5), age (p = 0.003) and GRS (p = 2.81 × 10-5, p = 0.0002 after permutation). No GRS resulted for adiponectin or high-density lipoprotein cholesterol. Rs2161829 and rs10490620 were selected for triglycerides; this GRS was insignificant after permutation.
  
  
  CONCLUSIONS
  INSIG2 plays a role in weight gain and obesity during clozapine treatment.
authors.affiliation: School of Medicine, University of Tampere, 33014 Tampere, Finland.
authors.forename: Suvi
authors.initials: S
authors.lastname: Koskinen
authors.affiliation: School of Medicine, University of Tampere, 33014 Tampere, Finland.|Department of Psychiatry, Seinäjoki Hospital District, Seinäjoki, Finland.
authors.forename: Olli
authors.initials: O
authors.lastname: Kampman
authors.affiliation: School of Medicine, University of Tampere, 33014 Tampere, Finland.|Department of Psychiatry, Seinäjoki Hospital District, Seinäjoki, Finland.
authors.forename: Anssi
authors.initials: A
authors.lastname: Solismaa
authors.affiliation: School of Medicine, University of Tampere, 33014 Tampere, Finland.|University of Tampere, School of Medicine, Department of Clinical Chemistry and Fimlab Laboratories, Tampere, Finland.
authors.forename: Leo-Pekka
authors.initials: LP
authors.lastname: Lyytikäinen
authors.affiliation: Department of Psychiatry, Tampere University Hospital, Tampere, Finland.
authors.forename: Niko
authors.initials: N
authors.lastname: Seppälä
authors.affiliation: School of Medicine, University of Tampere, 33014 Tampere, Finland.|Tampere Mental Health Centre, Tampere, Finland.
authors.forename: Merja
authors.initials: M
authors.lastname: Viikki
authors.affiliation: The Immunopharmacology Research Group, School of Medicine & Tampere University Hospital, University of Tampere, Tampere, Finland.
authors.forename: Mari
authors.initials: M
authors.lastname: Hämäläinen
authors.affiliation: The Immunopharmacology Research Group, School of Medicine & Tampere University Hospital, University of Tampere, Tampere, Finland.
authors.forename: Eeva
authors.initials: E
authors.lastname: Moilanen
authors.affiliation: University of Tampere, School of Medicine, Department of Clinical Chemistry and Fimlab Laboratories, Tampere, Finland.
authors.forename: Nina
authors.initials: N
authors.lastname: Mononen
authors.affiliation: School of Medicine, University of Tampere, 33014 Tampere, Finland.|University of Tampere, School of Medicine, Department of Clinical Chemistry and Fimlab Laboratories, Tampere, Finland.
authors.forename: Terho
authors.initials: T
authors.lastname: Lehtimäki
authors.affiliation: School of Medicine, University of Tampere, 33014 Tampere, Finland.|Department of Psychiatry, Tampere University Hospital, Tampere, Finland.
authors.forename: Esa
authors.initials: E
authors.lastname: Leinonen
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects*; D008076:Cholesterol, HDL / Q000097:blood; D003024:Clozapine / Q000009:adverse effects*; D050171:Dyslipidemias / Q000139:chemically induced*; D005260:Female; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics* / Q000502:physiology; D008297:Male; D008565:Membrane Proteins / Q000235:genetics* / Q000502:physiology; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000097:blood / Q000188:drug therapy* / Q000235:genetics; D015430:Weight Gain / Q000187:drug effects*
chemical_list: D052242:Adiponectin; D014150:Antipsychotic Agents; D008076:Cholesterol, HDL; C467727:INSIG2 protein, human; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D003024:Clozapine
keywords: BMI; INSIG2; adiponectin; cholesterol; clozapine; genetic association; polymorphism; single nucleotide; weight gain