title: Selagintriflavonoids with BACE1 inhibitory activity from the fern Selaginella doederleinii.
abstract: Eight triflavonoids, selagintriflavonoids A-H, were isolated from whole herbs of Selaginella doederleinii. The structures of compounds selagintriflavonoids A-C consisted of three naringenin units, whereas those of selagintriflavonoids D-H consisted of apigenin and two naringenin moieties. The structures and absolute configurations of the compounds were determined based on NMR, HRESIMS, and experimental and calculated electronic circular dichroism (ECD) data. The ability of the compounds to inhibit β-secretase (BACE1) was also evaluated. All compounds exhibited BACE1 inhibition with IC50values ranging from 0.75 to 46.99 μM. Selagintriflavonoid A exhibited the strongest inhibition (0.75 μM) and is thus a promising compound for treating Alzheimer's disease.
authors.affiliation: Xiangya Hospital of Central South University, Changsha, 410008, People's Republic of China; School of Pharmaceutical Sciences, Central South University, Changsha, 410013, People's Republic of China.
authors.forename: Zhenxing
authors.initials: Z
authors.lastname: Zou
authors.affiliation: Xiangya Hospital of Central South University, Changsha, 410008, People's Republic of China.
authors.forename: Pingsheng
authors.initials: P
authors.lastname: Xu
authors.affiliation: Xiangya Hospital of Central South University, Changsha, 410008, People's Republic of China.
authors.forename: Guogang
authors.initials: G
authors.lastname: Zhang
authors.affiliation: School of Pharmaceutical Sciences, Central South University, Changsha, 410013, People's Republic of China.
authors.forename: Fei
authors.initials: F
authors.lastname: Cheng
authors.affiliation: School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, 510641, People's Republic of China.
authors.forename: Kai
authors.initials: K
authors.lastname: Chen
authors.affiliation: School of Pharmaceutical Sciences, Central South University, Changsha, 410013, People's Republic of China.
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.affiliation: School of Pharmaceutical Sciences, Central South University, Changsha, 410013, People's Republic of China.
authors.forename: Weixing
authors.initials: W
authors.lastname: Zhu
authors.affiliation: School of Pharmaceutical Sciences, Central South University, Changsha, 410013, People's Republic of China.
authors.forename: Dongsheng
authors.initials: D
authors.lastname: Cao
authors.affiliation: School of Pharmaceutical Sciences, Central South University, Changsha, 410013, People's Republic of China. Electronic address: xukp395@csu.edu.cn.
authors.forename: Kangping
authors.initials: K
authors.lastname: Xu
authors.affiliation: Xiangya Hospital of Central South University, Changsha, 410008, People's Republic of China; School of Pharmaceutical Sciences, Central South University, Changsha, 410013, People's Republic of China. Electronic address: tgs395@csu.edu.cn.
authors.forename: Guishan
authors.initials: G
authors.lastname: Tan
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy*; D053829:Amyloid Precursor Protein Secretases / Q000037:antagonists & inhibitors*; D047310:Apigenin; D045744:Cell Line, Tumor; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D032503:Selaginellaceae / Q000737:chemistry*
chemical_list: D005419:Flavonoids; C000614554:selagintriflavonoid A; D047310:Apigenin; D053829:Amyloid Precursor Protein Secretases
keywords: Absolute configuration; BACE1; Selaginella; Selaginella doederleinii; Selaginellaceae; Triflavonoids