title: Effect of Methionine Restriction on Bone Density and NK Cell Activity.
abstract: Methionine restriction (MR) is proven to increase the lifespan; and it also affects the bone density and the innate immune system. The aim of this study is to explore the effect of methionine restriction on bone density and natural killer (NK) cells. C57BL/6J mice were subjected to either basal diet (BD, containing 0.80% methionine) or methionine-restricted diet (containing 0.14% methionine). Mice with MR diet displayed reduced bone mass and decrease in the cytotoxicity of NK from the spleen, compared to BD animals. Also, mice with MR diet had an inferior body weight (P< 0.05) and higher plasma levels of adiponectin and FGF21 (P< 0.05) but lower concentrations of leptin and IGF-1 (P< 0.05). Overall, the investigation shows that methionine affects bone density and NK cell cytotoxicity.
authors.affiliation: Tianjin Hospital, Jiefangnan Road 406, Tianjin 300210, China.
authors.forename: Mingxin
authors.identifier: 0000-0001-8252-2758
authors.initials: M
authors.lastname: Li
authors.affiliation: Department of Anatomy and Histology, Basic Medical College, Tianjin Medical University, Tianjin 300070, China.
authors.forename: Lidong
authors.identifier: 0000-0001-8491-4595
authors.initials: L
authors.lastname: Zhai
authors.affiliation: Tianjin Hospital, Jiefangnan Road 406, Tianjin 300210, China.
authors.forename: Wanfu
authors.identifier: 0000-0002-3561-8105
authors.initials: W
authors.lastname: Wei
authors.affiliation: Tianjin Hospital, Jiefangnan Road 406, Tianjin 300210, China.
authors.forename: Jingming
authors.initials: J
authors.lastname: Dong
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000818:Animals; D015519:Bone Density; D005346:Fibroblast Growth Factors / Q000097:blood*; D007694:Killer Cells, Natural / Q000378:metabolism* / Q000473:pathology; D020738:Leptin / Q000097:blood*; D008297:Male; D008715:Methionine / Q000172:deficiency*; D051379:Mice; D013154:Spleen / Q000378:metabolism / Q000473:pathology
chemical_list: D052242:Adiponectin; D020738:Leptin; C414620:fibroblast growth factor 21; D005346:Fibroblast Growth Factors; D008715:Methionine