title: The correlation between plasma brain-derived neurotrophic factor and cognitive function in bipolar disorder is modulated by the BDNF Val66Met polymorphism.
abstract: We explored the effect of the Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism (rs6265) on correlation between changes in plasma BDNF levels with cognitive function and quality of life (QoL) after 12 weeks of treatment in bipolar disorder (BD). Symptom severity and plasma BDNF levels were assessed upon recruitment and during weeks 1, 2, 4, 8 and 12. QoL, the Wisconsin Card Sorting Test (WCST), and the Conners' Continuous Performance Test (CPT) were assessed at baseline and endpoint. The BDNF Val66Met polymorphism was genotyped. Changes in cognitive function and QoL over 12 weeks were reduced using factor analysis for the evaluation of their correlations with changes in plasma BDNF. Five hundred forty-one BD patients were recruited and 65.6% of them completed the 12-week follow-up. Changes in plasma BDNF levels with factor 1 (WCST) were significantly negatively correlated (r = -0.25, p = 0.00037). After stratification of BD subtypes and BDNF genotypes, this correlation was significant only in BP-I and the Val/Met genotype (r = -0.54, p = 0.008). We concluded that changes in plasma BDNF levels significantly correlated with changes in WCST scores in BD and is moderated by the BDNF Val66Met polymorphism and the subtype of BD.
authors.affiliation: Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.|Department of Psychiatry, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.|Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan.|Department of Psychiatry, Faculty of Medicine, College of Medicine, Kaohsiung Medical University Kaohsiung, Taiwan.
authors.forename: Sheng-Yu
authors.initials: SY
authors.lastname: Lee
authors.affiliation: Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
authors.forename: Tzu-Yun
authors.initials: TY
authors.lastname: Wang
authors.affiliation: Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.|Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan.|Lipid Science and Aging Research Center, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
authors.forename: Shiou-Lan
authors.initials: SL
authors.lastname: Chen
authors.affiliation: Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan.|Deprtment of Psychology, Asia University, Taichung, Taiwan.
authors.forename: Yun-Hsuan
authors.initials: YH
authors.lastname: Chang
authors.affiliation: Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan.|Addiction Research Center, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
authors.forename: Po-See
authors.initials: PS
authors.lastname: Chen
authors.affiliation: Department of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
authors.forename: San-Yuan
authors.initials: SY
authors.lastname: Huang
authors.affiliation: Department of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.|Student Counseling Center, National Defense Medical Center, Taipei, Taiwan.
authors.forename: Nian-Sheng
authors.initials: NS
authors.lastname: Tzeng
authors.affiliation: Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.|Department of Child and Adolescent Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
authors.forename: Liang-Jen
authors.initials: LJ
authors.lastname: Wang
authors.affiliation: Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan.|Addiction Research Center, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
authors.forename: I Hui
authors.initials: IH
authors.lastname: Lee
authors.affiliation: Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan.|Addiction Research Center, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
authors.forename: Kao Chin
authors.initials: KC
authors.lastname: Chen
authors.affiliation: Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan.|Addiction Research Center, College of Medicine, National Cheng Kung University, Tainan, Taiwan.|Department of Psychiatry, National Cheng Kung University Hospital, Dou-Liou Branch, Yunlin, Taiwan.|Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan, National Cheng Kung University, Tainan, Taiwan.
authors.forename: Yen Kuang
authors.initials: YK
authors.lastname: Yang
authors.affiliation: School of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan.
authors.forename: Yi-Hsin
authors.initials: YH
authors.lastname: Yang
authors.affiliation: Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan.|Addiction Research Center, College of Medicine, National Cheng Kung University, Tainan, Taiwan.|Department of Psychiatry, National Cheng Kung University Hospital, Dou-Liou Branch, Yunlin, Taiwan.|Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan, National Cheng Kung University, Tainan, Taiwan.|Center for Neuropsychiatric Research, National Health Research Institutes, Miaoli, Taiwan.
authors.forename: Ru-Band
authors.initials: RB
authors.lastname: Lu
authors.affiliation: Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.|Department of Psychiatry, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.|Department of Psychiatry, Faculty of Medicine, College of Medicine, Kaohsiung Medical University Kaohsiung, Taiwan.
authors.forename: Cheng-Sheng
authors.initials: CS
authors.lastname: Chen
mesh_terms: D000328:Adult; D019943:Amino Acid Substitution; D001714:Bipolar Disorder / Q000097:blood / Q000188:drug therapy* / Q000235:genetics / Q000523:psychology*; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood* / Q000235:genetics; D003071:Cognition / Q000187:drug effects; D003915:Dextromethorphan / Q000008:administration & dosage* / Q000494:pharmacology; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D012720:Severity of Illness Index; D014635:Valproic Acid / Q000008:administration & dosage* / Q000494:pharmacology; D055815:Young Adult
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D014635:Valproic Acid; C579455:BDNF protein, human; D003915:Dextromethorphan