title: Optimal Duration of Dual Antiplatelet Therapy After Percutaneous Coronary Intervention.
abstract: Dual antiplatelet therapy (DAPT) is an essential component of treatment in patients with coronary artery disease treated with percutaneous coronary intervention (PCI). Recommendations for duration of DAPT after PCI should consider patient-specific risk, clinical presentation, stent characteristics, and procedural factors. Prolonged DAPT results in a reduction of stent thrombosis (ST) and myocardial infarction (MI) at the cost of increased bleeding. Studies of shorter-duration DAPT demonstrate similar mortality, MI, ST, and less bleeding when compared with longer DAPT duration. We review current evidence for strategies of prolonged DAPT and abbreviated DAPT following PCI.
authors.affiliation: Landsman Heart and Vascular Center, Lahey Hospital and Medical Center, 41 Burlington Mall Road, Burlington, MA 01805, USA.
authors.forename: Arjun
authors.initials: A
authors.lastname: Majithia
authors.affiliation: Heart & Vascular Center, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA. Electronic address: dlbhattmd@post.harvard.edu.
authors.forename: Deepak L
authors.initials: DL
authors.lastname: Bhatt
mesh_terms: D003324:Coronary Artery Disease / Q000188:drug therapy / Q000601:surgery*; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D006801:Humans; D062645:Percutaneous Coronary Intervention; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage*; D011182:Postoperative Care / Q000379:methods*
chemical_list: D010975:Platelet Aggregation Inhibitors
keywords: Coronary artery disease; Dual antiplatelet therapy; Percutaneous coronary intervention