title: Restorative Treatments for Spinal Cord Injury.
abstract: Spinal cord injury remains an incurable disease with an enormous impact functionally, financially, and emotionally on affected individuals and their families. Current treatment modalities are focused on minimizing secondary injury and maximizing residual function via rehabilitation. In this article, the authors discuss ambitious advancements under investigation aimed at restoring function. These promising experimental treatments focus on neuroprotection with hypothermia and pharmacologic therapies, regeneration via cell transplantation, and rewiring with electrical stimulation.
authors.affiliation: Department of Neurological Surgery, The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, 1095 Northwest 14th Terrace (D4-6), Miami, FL 33136, USA.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Chen
authors.affiliation: Department of Neurological Surgery, The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, 1095 Northwest 14th Terrace (D4-6), Miami, FL 33136, USA. Electronic address: ALevi@med.miami.edu.
authors.forename: Allan D
authors.initials: AD
authors.lastname: Levi
mesh_terms: D004599:Electric Stimulation Therapy; D006801:Humans; D007036:Hypothermia, Induced; D000066829:Neuroprotection; D020127:Recovery of Function; D013119:Spinal Cord Injuries / Q000628:therapy*; D016896:Treatment Outcome
keywords: Cell-based therapies; Electrical stimulation; Neuroprotection; Spinal cord injury