title: Sargachromenol protects against vascular inflammation by preventing TNF-α-induced monocyte adhesion to primary endothelial cells via inhibition of NF-κB activation.
abstract: Vascular inflammation is a key factor in the pathogenesis of atherosclerosis. The purpose of this study was to investigate the protective effects of sargachromenol (SCM) against tumor necrosis factor (TNF)-α-induced vascular inflammation. SCM decreased the expression of cell adhesion molecules, including intracellular adhesion molecule-1 and vascular cell adhesion molecule-1, in TNF-α-stimulated human umbilical vein endothelial cells (HUVECs), resulted in reduced adhesion of monocytes to HUVECs. SCM also decreased the production of monocyte chemoattractant protein-1 and matrix metalloproteinase-9 in TNF-α-induced HUVECs. Additionally, SCM inhibited activation of nuclear factor kappa B (NF-κB) induced by TNF-α through preventing the degradation of inhibitor kappa B. Moreover, SCM reduced the production of reactive oxygen species in TNF-α-treated HUVECs. Overall, SCM alleviated vascular inflammation through the regulation of NF-κB activation and through its intrinsic antioxidant activity in TNF-α-induced HUVECs. These results indicate that SCM may have potential application as a therapeutic agent against vascular inflammation.
authors.affiliation: Department of Food Science and Nutrition, Pukyong National University, Nam-gu, Busan 48513, Republic of Korea.
authors.forename: Wi-Gyeong
authors.initials: WG
authors.lastname: Gwon
authors.affiliation: Department of Food Science and Nutrition, Pukyong National University, Nam-gu, Busan 48513, Republic of Korea.
authors.forename: Eun-Ji
authors.initials: EJ
authors.lastname: Joung
authors.affiliation: Department of Food Science and Nutrition, Pukyong National University, Nam-gu, Busan 48513, Republic of Korea.
authors.forename: Mi-Sung
authors.initials: MS
authors.lastname: Kwon
authors.affiliation: Department of Food Science and Nutrition, Pukyong National University, Nam-gu, Busan 48513, Republic of Korea.
authors.forename: Su-Jin
authors.initials: SJ
authors.lastname: Lim
authors.affiliation: Department of Pathobiological Science, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA, USA.
authors.forename: Tadanobu
authors.initials: T
authors.lastname: Utsuki
authors.affiliation: Department of Food Science and Nutrition, Pukyong National University, Nam-gu, Busan 48513, Republic of Korea. Electronic address: hrkim@pknu.ac.kr.
authors.forename: Hyeung-Rak
authors.initials: HR
authors.lastname: Kim
mesh_terms: D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001578:Benzopyrans / Q000494:pharmacology*; D002448:Cell Adhesion / Q000187:drug effects; D018932:Chemokine CCL2 / Q000378:metabolism; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000502:physiology; D061307:Human Umbilical Vein Endothelial Cells; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism; D009000:Monocytes / Q000187:drug effects* / Q000276:immunology; D016328:NF-kappa B / Q000378:metabolism*; D061251:Primary Cell Culture; D017382:Reactive Oxygen Species; D044647:Sargassum / Q000276:immunology*; D015398:Signal Transduction / Q000187:drug effects; D015533:Transcriptional Activation / Q000187:drug effects; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D019010:Vascular Cell Adhesion Molecule-1 / Q000378:metabolism
chemical_list: D000893:Anti-Inflammatory Agents; D001578:Benzopyrans; D018932:Chemokine CCL2; D016328:NF-kappa B; D017382:Reactive Oxygen Species; D014409:Tumor Necrosis Factor-alpha; D019010:Vascular Cell Adhesion Molecule-1; C503204:sargachromenol; D018799:Intercellular Adhesion Molecule-1
keywords: Adhesion molecule; Anti-inflammation; Human umbilical vein endothelial cells; Nuclear factor-κB; Sargachromenol