title: Novel cases of amyotrophic lateral sclerosis after treatment of cerebral arteriovenous malformationss.
abstract: Previous case studies reported nine patients with cerebral arteriovenous malformations (AVM) who developed amyotrophic lateral sclerosis (ALS) after AVM embolisation. Here, we describe three novel cases of ALS which developed 13-34 years after treatment, including embolisation, of cerebral AVM. This study provides further arguments supporting the thesis that embolisation of cerebral AVM might influence the risk of later ALS development.
authors.affiliation: Department of Neurology, University Hospital Zurich, Switzerland, and Helios-Klinik Hagen-Ambrock, Hagen, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Linnebank
authors.affiliation: Endovascular Neurosurgery, Barrow Neurological Institute, Saint Joseph's Hospital and Medical Center, Phoenix, AZ, USA.
authors.forename: Cameron G
authors.initials: CG
authors.lastname: McDougall
authors.affiliation: CeGaT GmbH - Center for Genomics and Transcriptomics, Tübingen, Germany.
authors.forename: Stefanie
authors.initials: S
authors.lastname: Krueger
authors.affiliation: CeGaT GmbH - Center for Genomics and Transcriptomics, Tübingen, Germany.
authors.forename: Saskia
authors.initials: S
authors.lastname: Biskup
authors.affiliation: Department of Neuropathology, University of Tübingen and German Centre for Neurodegenerative Diseases (DZNE), Tübingen, Germany.
authors.forename: Manuela
authors.initials: M
authors.lastname: Neumann
authors.affiliation: Department of Neurology, University Hospital Zurich, Switzerland.
authors.forename: Michael
authors.initials: M
authors.lastname: Weller
authors.affiliation: Department of Neuroradiology, University Hospital Zurich, Switzerland.
authors.forename: Antonios
authors.initials: A
authors.lastname: Valavanis
authors.affiliation: Department of Neurology, University of Rostock and German Centre for Neurodegenerative Diseases/ DZNE, Rostock, Germany.
authors.forename: Johannes
authors.initials: J
authors.lastname: Prudlo
mesh_terms: D000328:Adult; D000690:Amyotrophic Lateral Sclerosis / Q000209:etiology* / Q000473:pathology; D004621:Embolization, Therapeutic / Q000009:adverse effects*; D005260:Female; D006801:Humans; D002538:Intracranial Arteriovenous Malformations / Q000150:complications*; D008875:Middle Aged; D012307:Risk Factors; D013997:Time Factors