title: [Tocilizumab treatment of HHV8-positive/HIV-negative, multricentric plasma cell type Castleman's disease].
abstract: This is a case presentation of a HHV8-positive multicentric Castleman's disease (MCD) of plasma cell type. The patient failed to respond to combined immunosuppressive therapy and monoclonal anti-CD20 therapy. Interestingly, administration of anti-IL-6R antibody stabilized the disease and resulted in clearance of HHV8 from the involved lymph nodes.
authors.affiliation: II. Sz. Belgyógyászati Klinika, Semmelweis Egyetem, Budapest, Hungary. muzes.gyorgyi@med.semmelweis-univ.hu.
authors.forename: Györgyi
authors.initials: G
authors.lastname: Mûzes
authors.affiliation: I. Sz. Patológiai és Kísérleti Rákkutató Intézet, Semmelweis Egyetem, Budapest, Hungary.
authors.forename: Judit
authors.initials: J
authors.lastname: Csomor
authors.affiliation: II. Sz. Belgyógyászati Klinika, Semmelweis Egyetem, Budapest, Hungary. muzes.gyorgyi@med.semmelweis-univ.hu.
authors.forename: Ferenc
authors.initials: F
authors.lastname: Sipos
mesh_terms: D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use*; D005871:Castleman Disease / Q000188:drug therapy*; D006566:Herpesviridae Infections / Q000188:drug therapy*; D019288:Herpesvirus 8, Human / Q000302:isolation & purification; D006801:Humans; D008198:Lymph Nodes; D010950:Plasma Cells; D016896:Treatment Outcome
chemical_list: D061067:Antibodies, Monoclonal, Humanized; C502936:tocilizumab