title: Deferasirox pharmacokinetics evaluation in a woman with hereditary haemochromatosis and heterozygous β-thalassaemia.
abstract: We present the deferasirox pharmacokinetics evaluation of a female patient on iron chelation, for the interesting findings from her genetic background (hereditary haemochromatosis and heterozygous β-thalassaemia) and clinical history (ileostomy; iron overload from transfusions). Drug plasma concentrations were measured by an HPLC-UV validated method, before and after ileum resection. Area under deferasirox concentration curve over 24h (AUC) values were determined by the mixed log-linear rule, using Kinetica software. AUC was low also with high deferasirox dose as well as tolerability. Non invasive tissue iron quantification by magnetic resonance imaging or superconducting quantum interference device were prevented by a metal hip replacement. Good efficacy and normalisation of iron markers was obtained on long term. Therapeutic drug monitoring in patient in critical conditions may help to understand reasons for non response and set individualised treatment.
authors.affiliation: Department of Medical Sciences, Unit of Infectious Diseases, University of Turin, Amedeo di Savoia Hospital, Corso Svizzera 164, 10149, Turin, Italy. Electronic address: sarah.allegra@gmail.com.
authors.forename: Sarah
authors.initials: S
authors.lastname: Allegra
authors.affiliation: Department of Biological and Clinical Sciences, University of Turin, S. Luigi Gonzaga Hospital, Regione Gonzole 10, 10043, Orbassano (TO), Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: De Francia
authors.affiliation: Department of Biological and Clinical Sciences, University of Turin, S. Luigi Gonzaga Hospital, Regione Gonzole 10, 10043, Orbassano (TO), Italy.
authors.forename: Filomena
authors.initials: F
authors.lastname: Longo
authors.affiliation: Department of Biological and Clinical Sciences, University of Turin, S. Luigi Gonzaga Hospital, Regione Gonzole 10, 10043, Orbassano (TO), Italy.
authors.forename: Davide
authors.initials: D
authors.lastname: Massano
authors.affiliation: Department of Medical Sciences, Unit of Infectious Diseases, University of Turin, Amedeo di Savoia Hospital, Corso Svizzera 164, 10149, Turin, Italy.
authors.forename: Jessica
authors.initials: J
authors.lastname: Cusato
authors.affiliation: Department of Medical Sciences, Unit of Infectious Diseases, University of Turin, Amedeo di Savoia Hospital, Corso Svizzera 164, 10149, Turin, Italy.
authors.forename: Arianna
authors.initials: A
authors.lastname: Arduino
authors.affiliation: Department of Biological and Clinical Sciences, University of Turin, S. Luigi Gonzaga Hospital, Regione Gonzole 10, 10043, Orbassano (TO), Italy.
authors.forename: Elisa
authors.initials: E
authors.lastname: Pirro
authors.affiliation: Department of Biological and Clinical Sciences, University of Turin, S. Luigi Gonzaga Hospital, Regione Gonzole 10, 10043, Orbassano (TO), Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Piga
authors.affiliation: Department of Medical Sciences, Unit of Infectious Diseases, University of Turin, Amedeo di Savoia Hospital, Corso Svizzera 164, 10149, Turin, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: D'Avolio
mesh_terms: D001565:Benzoates / Q000097:blood* / Q000493:pharmacokinetics / Q000627:therapeutic use; D000077588:Deferasirox; D005260:Female; D006432:Hemochromatosis / Q000097:blood* / Q000188:drug therapy; D006801:Humans; D007502:Iron Chelating Agents / Q000493:pharmacokinetics* / Q000627:therapeutic use; D008875:Middle Aged; D014230:Triazoles / Q000097:blood* / Q000493:pharmacokinetics / Q000627:therapeutic use; D017086:beta-Thalassemia / Q000097:blood* / Q000188:drug therapy
chemical_list: D001565:Benzoates; D007502:Iron Chelating Agents; D014230:Triazoles; D000077588:Deferasirox
keywords: Deferasirox; Dfx; Haemochromatosis; Ileostomy; Iron chelation; Iron overload