title: The Effects of Hemodynamic Changes on Pulse Wave Velocity in Cardiothoracic Surgical Patients.
abstract: The effect of blood pressure on pulse wave velocity (PWV) is well established. However, PWV variability with acute hemodynamic changes has not been examined in the clinical setting. The aim of the present study is to investigate the effect of hemodynamic changes on PWV in patients who undergo cardiothoracic surgery. Using data from 25 patients, we determined blood pressure (BP), heart rate (HR), and the left ventricular outflow tract (LVOT) velocity-time integral. By superimposing the radial arterial waveform on the continuous wave Doppler waveform of the LVOT, obtained by transesophageal echo, we were able to determine pulse transit time and to calculate PWV, stroke volume (SV), cardiac output (CO), and systemic vascular resistance (SVR). Increases in BP, HR, and SVR were associated with higher values for PWV. In contrast increases in SV were associated with decreases in PWV. Changes in CO were not significantly associated with PWV.
authors.affiliation: Division of Cardiac Anesthesia, Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
authors.forename: Yurie
authors.identifier: 0000-0003-0764-3917
authors.initials: Y
authors.lastname: Obata
authors.affiliation: Department of Anesthesiology and Reanimatology, University of Fukui, Fukui, Japan.
authors.forename: Maki
authors.initials: M
authors.lastname: Mizogami
authors.affiliation: Division of Cardiac Anesthesia, Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
authors.forename: Sarabdeep
authors.initials: S
authors.lastname: Singh
authors.affiliation: Division of Cardiac Anesthesia, Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
authors.forename: Daniel
authors.initials: D
authors.lastname: Nyhan
authors.affiliation: Division of Cardiac Anesthesia, Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
authors.forename: Dan E
authors.initials: DE
authors.lastname: Berkowitz
authors.affiliation: Division of Cardiac Anesthesia, Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
authors.forename: Jochen
authors.identifier: 0000-0001-9856-512X
authors.initials: J
authors.lastname: Steppan
authors.affiliation: Division of Cardiac Anesthesia, Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
authors.forename: Viachaslau
authors.identifier: 0000-0002-0953-0994
authors.initials: V
authors.lastname: Barodka
mesh_terms: D000368:Aged; D001794:Blood Pressure / Q000502:physiology*; D002302:Cardiac Output / Q000502:physiology*; D006348:Cardiac Surgical Procedures; D005260:Female; D006339:Heart Rate / Q000502:physiology*; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D063177:Pulse Wave Analysis / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013318:Stroke Volume / Q000502:physiology; D019616:Thoracic Surgical Procedures; D014655:Vascular Resistance / Q000502:physiology; D059289:Vascular Stiffness / Q000502:physiology*