title: Renal shear wave velocity and estimated glomerular filtration rate in children with chronic kidney disease.
abstract: A shear wave velocity (SWV) value obtained by the acoustic radiation force impulse technique depends on tissue elasticity. We investigated the relationship between SWV values and the estimated glomerular filtration rate (eGFR) in children with chronic kidney disease. A total of 29 patients were enrolled in the study. There were 18 primary and 11 secondary cases of vesicoureteral reflux. eGFR was calculated using Schwartz's formulas (2012). Partial eGFR for each kidney was assessed by multiplying the eGFR by the percentage of renal function measured by means of renal (99m)Tc-dimercaptosuccinic acid scintigraphy. All ultrasound tests were done by a single qualified technician using a convex probe (frequency 4 MHz) on an S-2000 system. The mean SWV values of the two kidneys were significantly and negatively correlated with eGFR calculated with both univariate (cystatin C [Cys C] and multivariate (creatinine, Cys C, and nitrogen) equations. Of all the formulae, the strongest correlation was obtained with eGFR (Cys C). SWV of the renal cortex correlates with the eGFR of patients affected by malformative uropathies. Nevertheless, this technique needs standardization and validation.
authors.affiliation: Department of Radiology, Dentistry, Gynecology and Pediatrics, Pediatric Division, University of Verona, Verona, Italy.
authors.forename: Costanza
authors.initials: C
authors.lastname: Bruno
authors.affiliation: Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, Pediatric Division, University of Verona, Verona, Italy.
authors.forename: Milena
authors.initials: M
authors.lastname: Brugnara
authors.affiliation: Department of Psychology and Cognitive Sciences, University of Trento, Trento, Italy.
authors.forename: Rocco
authors.initials: R
authors.lastname: Micciolo
authors.affiliation: Department of Pediatric Surgery, University of Verona, Verona, Italy.
authors.forename: Mariangela
authors.initials: M
authors.lastname: Cecchetto
authors.affiliation: Department of Nuclear Medicine, University of Verona, Verona, Italy.
authors.forename: Michele
authors.initials: M
authors.lastname: Zuffante
authors.affiliation: Department of Radiology, Dentistry, Gynecology and Pediatrics, Pediatric Division, University of Verona, Verona, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Bucci
authors.affiliation: Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, Pediatric Division, University of Verona, Verona, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Zaffanello
mesh_terms: D002648:Child; D003404:Creatinine; D055316:Cystatin C; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney; D051436:Renal Insufficiency, Chronic
chemical_list: D055316:Cystatin C; D003404:Creatinine