title: Condensin Regulation of Genome Architecture.
abstract: Condensin complexes exist across all domains of life and are central to the structure and organization of chromatin. As architectural proteins, condensins control chromatin compaction during interphase and mitosis. Condensin activity has been well studied in mitosis but have recently emerged as important regulators of genome organization and gene expression during interphase. Here, we focus our discussion on recent findings on the molecular mechanism and how condensins are used to shape chromosomes during interphase. These findings suggest condensin activity during interphase is required for proper chromosome organization. J. Cell. Physiol. 232: 1617-1625, 2017. © 2016 Wiley Periodicals, Inc.
authors.affiliation: Department of Molecular Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire.
authors.forename: Vibhuti
authors.initials: V
authors.lastname: Rana
authors.affiliation: Department of Molecular Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Bosco
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000818:Animals; D002453:Cell Cycle; D002875:Chromosomes / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism*; D016678:Genome; D006801:Humans; D008954:Models, Biological; D046912:Multiprotein Complexes / Q000378:metabolism*
chemical_list: D004268:DNA-Binding Proteins; D046912:Multiprotein Complexes; C108312:condensin complexes; D000251:Adenosine Triphosphatases