title: Aloe QDM complex enhances specific cytotoxic T lymphocyte killing in vivo in metabolic disease mice.
abstract: We developed spontaneous diet-induced metabolic disease in mice by feeding them a high-fat diet for 23 weeks and administered Aloe QDM complex for 16 weeks to examine its restorative effect on immune disorders and metabolic syndrome. A series of immune functional assays indicated Aloe QDM complex enhanced lymphocyte proliferation and antigen-specific immunity as determined by the restored functions of cytotoxic T lymphocytes (CTL) and IgG production. The elevated serum TNF-α level was also regulated by Aloe QDM complex treatment, which suggested its complex therapeutic potential. As for metabolic phenotypes, oral administration of Aloe QDM complex significantly improved diabetic symptoms, including high fasting glucose levels and glucose tolerance, and distinctly alleviated lipid accumulation in adipose and hepatic tissue. The simultaneous restoration of Aloe QDM complex on metabolic syndrome and host immune dysfunction, especially on the specific CTL killing was first elucidated in our study.
authors.affiliation: a College of Pharmacy, Sahmyook University , Seoul , Korea.
authors.forename: Youngjoo
authors.initials: Y
authors.lastname: Lee
authors.affiliation: a College of Pharmacy, Sahmyook University , Seoul , Korea.
authors.forename: Jiyeon
authors.initials: J
authors.lastname: Kim
authors.affiliation: a College of Pharmacy, Sahmyook University , Seoul , Korea.
authors.forename: Jinho
authors.initials: J
authors.lastname: An
authors.affiliation: a College of Pharmacy, Sahmyook University , Seoul , Korea.
authors.forename: Heetae
authors.initials: H
authors.lastname: Lee
authors.affiliation: a College of Pharmacy, Sahmyook University , Seoul , Korea.
authors.forename: Hyunseok
authors.initials: H
authors.lastname: Kong
authors.affiliation: a College of Pharmacy, Sahmyook University , Seoul , Korea.
authors.forename: Youngcheon
authors.initials: Y
authors.lastname: Song
authors.affiliation: b Wellness R&D Center, Univera, Inc. , Seoul , Korea.
authors.forename: Eunju
authors.initials: E
authors.lastname: Shin
authors.affiliation: b Wellness R&D Center, Univera, Inc. , Seoul , Korea.
authors.forename: Seon-Gil
authors.initials: SG
authors.lastname: Do
authors.affiliation: c College of Pharmacy, Chungbuk National University , Cheongju , Korea.
authors.forename: Chong-Kil
authors.initials: CK
authors.lastname: Lee
authors.affiliation: a College of Pharmacy, Sahmyook University , Seoul , Korea.
authors.forename: Kyungjae
authors.initials: K
authors.lastname: Kim
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects / Q000473:pathology; D000284:Administration, Oral; D000504:Aloe / Q000737:chemistry*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D059305:Diet, High-Fat / Q000009:adverse effects; D004195:Disease Models, Animal; D006943:Hyperglycemia / Q000188:drug therapy / Q000209:etiology; D006949:Hyperlipidemias / Q000188:drug therapy / Q000209:etiology; D007074:Immunoglobulin G / Q000097:blood; D050356:Lipid Metabolism / Q000187:drug effects; D008297:Male; D024821:Metabolic Syndrome / Q000188:drug therapy* / Q000209:etiology; D008810:Mice, Inbred C57BL; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry; D013602:T-Lymphocytes, Cytotoxic / Q000187:drug effects* / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D001786:Blood Glucose; D007074:Immunoglobulin G; D010936:Plant Extracts; D014409:Tumor Necrosis Factor-alpha
keywords: Aloe QDM complex; antidiabetic effect; diet-induced metabolic disease mice; immunomodulation; in vivo cytotoxic T lymphocyte