title: Target-based approaches for the discovery of new antimycobacterial drugs.
abstract: Tuberculosis (TB) is a major global health problem and control of the disease is hampered by the increasing emergence of multidrug resistance (MDR) strains. Novel drugs are urgently needed to overcome drug resistance. Among the most relevant targets of the past 3 years, herein we consider nine enzymes that have been studied in a target-based approach. These targets are involved mainly in the biosynthesis of the cell wall, α-glucan, coenzyme A and acyl carrier protein precursor, and in energy production, DNA metabolism, and pyrimidine synthesis. Some leads and many hits have been discovered using a target-based approach and can be further developed in a drug discovery process.
authors.affiliation: Department of Life Sciences, University of Modena and Reggio Emilia, Via G. Campi 103, 41125 Modena, Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Borsari
authors.affiliation: Department of Life Sciences, University of Modena and Reggio Emilia, Via G. Campi 103, 41125 Modena, Italy.
authors.forename: Stefania
authors.initials: S
authors.lastname: Ferrari
authors.affiliation: Tydock Pharma srl, Strada Gherbella 294/B, Modena 41126, Italy.
authors.forename: Alberto
authors.initials: A
authors.lastname: Venturelli
authors.affiliation: Department of Life Sciences, University of Modena and Reggio Emilia, Via G. Campi 103, 41125 Modena, Italy; Tydock Pharma srl, Strada Gherbella 294/B, Modena 41126, Italy. Electronic address: mariapaola.costi@unimore.it.
authors.forename: Maria Paola
authors.initials: MP
authors.lastname: Costi
mesh_terms: D000995:Antitubercular Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism*; D055808:Drug Discovery; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000201:enzymology
chemical_list: D000995:Antitubercular Agents; D001426:Bacterial Proteins