title: Evaluation of inhomogeneities of repolarization in patients with psoriasis vulgaris.
abstract: BACKGROUND
  The arrhythmia potential has not been investigated adequately in psoriatic patients. In this study, we assessed the ventricular repolarization dispersion, using the Tp-e interval and the Tp-e/QT ratio, and investigated the association with inflammation.
  
  
  METHODS
  Seventy-one psoriasis vulgaris patients and 70 age- and gender-matched healthy individuals were enrolled in the study. The severity of the disease was calculated using Psoriasis Area and Severity Index scoring. The QTd was defined as the difference between the maximum and minimum QT intervals. The Tp-e interval was defined as the interval from the peak of the T wave to the end of the T wave. The Tp-e interval was corrected for heart rate. The Tp-e/QT ratio was calculated using these measurements.
  
  
  RESULTS
  There were no significant differences between the groups with respect to basal clinical and laboratory characteristics (p> 0.05). The Tp-e interval, the corrected Tp-e interval (cTp-e) and the Tp-e/QT ratio were also significantly higher in psoriasis patients compared to the control group (78.5 ±8.0 ms vs. 71.4 ±7.6 ms,p< 0.001, 86.3 ±13.2 ms vs. 77.6 ±9.0 ms,p< 0.001 and 0.21 ±0.02 vs. 0.19 ±0.02,p< 0.001 respectively). A significant correlation was detected between the cTp-e time and the Tp-e/QT ratio and the PASI score in the group of psoriatic patients (r= 0.51,p< 0.001;r= 0.59,p< 0.001, respectively).
  
  
  CONCLUSIONS
  In our study, we detected a significant increase in the Tp-e interval and the Tp-e/QT ratio in patients with psoriasis vulgaris. The Tp-e interval and the Tp-e/QT ratio may be predictors for ventricular arrhythmias in patients with psoriasis vulgaris.
authors.affiliation: Department of Cardiology, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey.
authors.forename: Korhan
authors.initials: K
authors.lastname: Soylu
authors.affiliation: Department of Cardiology, Aksaray State Hospital, Aksaray, Turkey.
authors.forename: Sinan
authors.initials: S
authors.lastname: İnci
authors.affiliation: Department of Cardiology, Gazi State Hospital, Samsun, Turkey.
authors.forename: Gökhan
authors.initials: G
authors.lastname: Aksan
authors.affiliation: Department of Cardiology, Aksaray State Hospital, Aksaray, Turkey.
authors.forename: Gökay
authors.initials: G
authors.lastname: Nar
authors.affiliation: Department of Dermatology, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey.
authors.forename: Esra Pancar
authors.initials: EP
authors.lastname: Yüksel
authors.affiliation: Department of Dermatology, Gazi State Hospital, Samsun, Turkey.
authors.forename: Hande Serra
authors.initials: HS
authors.lastname: Ocal
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, Amasya University, Amasya, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Çapraz
authors.affiliation: Department of Cardiology, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey.
authors.forename: Serkan
authors.initials: S
authors.lastname: Yüksel
authors.affiliation: Department of Cardiology, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey.
authors.forename: Mahmut
authors.initials: M
authors.lastname: Şahin
keywords: Tp-e interval; Tp-e/QT ratio; psoriasis vulgaris