title: Redox Paradox: Can Hypoxia Heal Ischemic Hearts?
abstract: Adult cardiomyocytes are largely thought to lack proliferative and therefore regenerative potential. Reporting in Nature, Nakada et al. (2016) find that a hypoxic regime reduces mitochondrial metabolism and promotes proliferation in adult mouse cardiomyocytes, resulting in increased regeneration following myocardial infarction. These findings suggest the potential to transform post-MI care.
authors.affiliation: Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, La Jolla, CA 92093, USA.
authors.forename: Nuno
authors.initials: N
authors.lastname: Guimarães-Camboa
authors.affiliation: Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, La Jolla, CA 92093, USA; Department of Medicine, University of California at San Diego, La Jolla, CA 92093, USA; Department of Pharmacology, University of California at San Diego, La Jolla, CA 92093, USA. Electronic address: syevans@ucsd.edu.
authors.forename: Sylvia M
authors.initials: SM
authors.lastname: Evans
mesh_terms: D000818:Animals; D000860:Hypoxia; D051379:Mice; D009203:Myocardial Infarction; D032383:Myocytes, Cardiac; D010084:Oxidation-Reduction; D012038:Regeneration