title: Fluorinated alcohol-mediated [4 + 3] cycloaddition reaction of indolyl alcohols with cyclopentadiene.
abstract: This paper describes an efficient [4 + 3] cycloaddition reaction of 3-indolylmethanols with cyclopentadiene in hexafluoroisopropanol (HFIP), which is catalyst-free and inexpensive, and offers mild reaction conditions, wide substrate scope and convenient workup. This methodology provides the first catalyst- and additive-free [4 + 3] cycloaddition reactions of indolyl alcohols, offering a green and efficient method for the synthesis of cyclohepta[b]indole derivatives.
authors.affiliation: College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao, 266109, China. chemjianxiao@163.com.
authors.forename: Jian
authors.initials: J
authors.lastname: Liu
authors.affiliation: College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao, 266109, China. chemjianxiao@163.com.
authors.forename: Liang
authors.initials: L
authors.lastname: Wang
authors.affiliation: College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao, 266109, China. chemjianxiao@163.com.
authors.forename: Xiaoxiao
authors.initials: X
authors.lastname: Wang
authors.affiliation: College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao, 266109, China. chemjianxiao@163.com.
authors.forename: Lubin
authors.initials: L
authors.lastname: Xu
authors.affiliation: College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao, 266109, China. chemjianxiao@163.com.
authors.forename: Zhihui
authors.initials: Z
authors.lastname: Hao
authors.affiliation: College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao, 266109, China. chemjianxiao@163.com.
authors.forename: Jian
authors.initials: J
authors.lastname: Xiao