title: Heterotopic Ossification in Trauma.
abstract: Better understanding of the biology of heterotopic ossification (HO) formation will lead to treatment and prevention modalities that can be directed specifically at the cellular level. Early identification of HO precursor cells and target genes may provide prognostic value that guides individualized prophylactic treatment. Better understanding of molecular signaling and proteomics variability will allow surgeons to individualize preemptive treatment to suppress inflammation and formation of HO. Careful surgical technique to avoid muscle damage is important. Damaged muscle should be debrided as a prophylactic measure. Hemostasis and avoidance of a postoperative hematoma may decrease the chance of formation of HO.
authors.affiliation: Department of Orthopaedics, Medical University of South Carolina, 96 Jonathan Lucas Street-Suite 708, Charleston, SC 29425, USA.
authors.forename: William R
authors.initials: WR
authors.lastname: Barfield
authors.affiliation: Department of Orthopaedics, Medical University of South Carolina, 96 Jonathan Lucas Street-Suite 708, Charleston, SC 29425, USA.
authors.forename: Robert E
authors.initials: RE
authors.lastname: Holmes
authors.affiliation: Department of Orthopaedics, Medical University of South Carolina, 96 Jonathan Lucas Street-Suite 708, Charleston, SC 29425, USA. Electronic address: hartsock@musc.edu.
authors.forename: Langdon A
authors.initials: LA
authors.lastname: Hartsock
mesh_terms: D006801:Humans; D009999:Ossification, Heterotopic / Q000209:etiology*; D012307:Risk Factors; D014947:Wounds and Injuries / Q000150:complications*
keywords: Chemical prophylaxis; Classification; Heterotopic ossification; Pathophysiology; Radiation; Surgical debridement; Surgical excision