title: Solid-phase extraction with metal-organic frameworks for the analysis of chiral compounds.
abstract: Metal-organic frameworks (MOFs) are excellent porous materials with nanoscale cavities and high surface areas, which make them promising as novel adsorbents in solid-phase extraction (SPE). In this article we report a new application of the chiral MOF [Zn2(D-Cam)2(4,4'-bpy)]nin SPE used for the measurement of the enantiomeric excess (ee) of (±)-1,1'-bi-2-naphthol. Several important experimental parameters that may influence the extraction efficiency were investigated and optimized. Under the optimum conditions, a good linearity (R2> 0.999) was found between the ee value and the reciprocal of the peak areas. When compared with the actual ee measured using chiral HPLC, the SPE-based assay also showed good accuracy and precision. The results showed that SPE based on chiral MOFs as adsorbents is a simple and effective method for the determination of the ee values of chiral compounds.
authors.affiliation: Department of Chemistry, Yunnan Normal University, Kunming, People's Republic of China.
authors.forename: Bo
authors.initials: B
authors.lastname: Tang
authors.affiliation: Department of Chemistry, Yunnan Normal University, Kunming, People's Republic of China.
authors.forename: Jun-Hui
authors.initials: JH
authors.lastname: Zhang
authors.affiliation: Department of Chemistry, Yunnan Normal University, Kunming, People's Republic of China.
authors.forename: Min
authors.initials: M
authors.lastname: Zi
authors.affiliation: Department of Chemistry, Yunnan Normal University, Kunming, People's Republic of China.
authors.forename: Xue-Xian
authors.initials: XX
authors.lastname: Chen
authors.affiliation: Department of Chemistry, Yunnan Normal University, Kunming, People's Republic of China.
authors.forename: Li-Ming
authors.initials: LM
authors.lastname: Yuan
keywords: chiral compounds; chiral separation; metal-organic frameworks; quantitative analysis; solid-phase extraction