title: Genetic association study between RIT2 and Parkinson's disease in a Han Chinese population.
abstract: Recent several meta-analyses and certain case-control studies suggested that the Ras-like without CAAX 2 (RIT2) rs12456492 increased the risk of Parkinson's disease (PD) in Asian and Caucasian populations. However, as so far, the association between RIT2 rs12456492 and PD is still controversial. We investigated genetic association of RIT2 rs12456492 with PD susceptibility in a Han Chinese population of 1747 ethnic Han Chinese subjects comprising 884 PD patients and 863 healthy controls. The minor allele frequency (MAF) of G at the RIT2 rs12456492 was not significantly different between the cases and the controls. Furthermore, no significant differences were observed in genotype distribution between PD patients and healthy controls for the RIT2 rs12456492, even after being stratified by age at onset and gender. In addition, we found that no significant differences were detected in the clinical manifestations for gender, age at onset, and onset symptoms between PD patients with AG + GG genotypes and those with AA genotypes. Our study from the mainland China demonstrates that RIT2 rs12456492 do not increase the risk of developing PD. Therefore, more replication studies in additional Chinese population and other cohorts are warranted to further clarify the role of RIT2 rs12456492 in PD susceptibility.
authors.affiliation: Department of Neurology, West China Hospital, Sichuan University, 610041, Sichuan, People's Republic of China.
authors.forename: Jun-Ying
authors.initials: JY
authors.lastname: Li
authors.affiliation: Department of Neurology, West China Hospital, Sichuan University, 610041, Sichuan, People's Republic of China.|Department of Internal Medicine, Wangjiang Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.
authors.forename: Jin-Hong
authors.initials: JH
authors.lastname: Zhang
authors.affiliation: Department of Neurology, West China Hospital, Sichuan University, 610041, Sichuan, People's Republic of China.
authors.forename: Nan-Nan
authors.initials: NN
authors.lastname: Li
authors.affiliation: Department of Neurology, West China Hospital, Sichuan University, 610041, Sichuan, People's Republic of China.
authors.forename: Ling
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Neurology, West China Hospital, Sichuan University, 610041, Sichuan, People's Republic of China.
authors.forename: Zhong-Jiao
authors.initials: ZJ
authors.lastname: Lu
authors.affiliation: Department of Neurology, West China Hospital, Sichuan University, 610041, Sichuan, People's Republic of China.
authors.forename: Lan
authors.initials: L
authors.lastname: Cheng
authors.affiliation: Department of Neurology, West China Hospital, Sichuan University, 610041, Sichuan, People's Republic of China.
authors.forename: Xiao-Yi
authors.initials: XY
authors.lastname: Sun
authors.affiliation: Department of Neurology, West China Hospital, Sichuan University, 610041, Sichuan, People's Republic of China. qrongpeng@q126.com.
authors.forename: Rong
authors.initials: R
authors.lastname: Peng
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002681:China; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D008875:Middle Aged; D020559:Monomeric GTP-Binding Proteins / Q000235:genetics*; D010300:Parkinson Disease / Q000235:genetics*; D055815:Young Adult
chemical_list: D020559:Monomeric GTP-Binding Proteins; C583559:RiT2 protein, human
keywords: Parkinson’s disease; RIT2; rs12456492