title: Magnetic Resonance Imaging in the Pre-Surgical Staging of Breast Cancer: Our Experience.
abstract: OBJECTIVE
  To investigate the clinical impact of magnetic resonance imaging (MRI) in the detection of multifocal-multicentric breast cancers, already identified by mammography and ultrasound, and analyzed histologically, to evaluate its role in preoperative staging.
  
  
  METHODS
  From January 2012 to February 2014, 188 patients, aged 28 to 74 years, newly diagnosed with breast cancer on conventional imaging (mammography and ultrasound) were enrolled. They underwent preoperative contrast-enhanced 3T MRI. Patients underwent surgery according to international guidelines. Results of all diagnostic procedures were compared.
  
  
  RESULTS
  Among the 188 patients, 163 (87%) had a unilateral and unifocal tumor at both conventional imaging; MRI diagnosed 22/22 (100%) of multifocal and multicentric tumors, the combination of mammography and ultrasound diagnosed 12/22 (54%), and mammography alone diagnosed 8/22 (36%) multifocal and multicentric tumors. MRI prompted a change in surgical strategy in 10/188 (5%) patients. This change comprised mastectomy instead of conservative surgery (n = 7) and more extensive conservative surgery (n = 3).
  
  
  CONCLUSIONS
  MRI was confirmed to show higher sensitivity than conventional imaging in detecting multifocal and multicentric breast cancers.
authors.affiliation: a IRCCS-CROB , Rionero in Vulture , Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Rabasco
authors.affiliation: a IRCCS-CROB , Rionero in Vulture , Italy.
authors.forename: Rocchina
authors.initials: R
authors.lastname: Caivano
authors.affiliation: a IRCCS-CROB , Rionero in Vulture , Italy.
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Dinardo
authors.affiliation: a IRCCS-CROB , Rionero in Vulture , Italy.
authors.forename: Matilde
authors.initials: M
authors.lastname: Gioioso
authors.affiliation: a IRCCS-CROB , Rionero in Vulture , Italy.
authors.forename: Antonella
authors.initials: A
authors.lastname: Lotumolo
authors.affiliation: a IRCCS-CROB , Rionero in Vulture , Italy.
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Iannelli
authors.affiliation: a IRCCS-CROB , Rionero in Vulture , Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Villonio
authors.affiliation: a IRCCS-CROB , Rionero in Vulture , Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: La Torre
authors.affiliation: a IRCCS-CROB , Rionero in Vulture , Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: D'Errico
authors.affiliation: b Department of Radiology , University of Foggia , Foggia , Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Macarini
authors.affiliation: b Department of Radiology , University of Foggia , Foggia , Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Guglielmi
authors.affiliation: a IRCCS-CROB , Rionero in Vulture , Italy.
authors.forename: Aldo
authors.initials: A
authors.lastname: Cammarota
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008327:Mammography; D008875:Middle Aged; D009367:Neoplasm Staging; D057234:Preoperative Period; D012680:Sensitivity and Specificity; D014463:Ultrasonography
keywords: Breast cancer; MRI; mammography; multifocal–multicentric cancer; ultrasound