title: DQB1*060101 may contribute to susceptibility to immunoglobulin A nephropathy in southern Han Chinese.
abstract: Immunoglobulin A nephropathy (IgAN) is a common form of chronic glomerulonephritis with unknown pathogenesis. Accumulating evidences have shown the ethnic-specific association between certain human leukocyte antigen (HLA) alleles and IgAN susceptibility. This study was designed to explore the relationship between HLA-DQB1 alleles and disease susceptibility and clinical manifestations of patients with IgAN in southern Han Chinese. A PCR sequence-based typing technique was used to detect HLA-DQB1 alleles in 217 IgAN patients and 229 healthy subjects. Clinical data were collected from each patient at the time of renal biopsy. Twenty HLA-DQB1 alleles were detected in IgAN patients and healthy subjects. High frequency of HLA-DQB1* 060101 and low frequency of HLA-DQB1*030101 were observed in IgAN patients compared with healthy controls. Further stratification analysis revealed that the frequency of DQB1*060101 was significantly higher in patients with urine protein ≥ 1.0 g/24 h than in patients with urine protein < 1.0 g/24 h. In combination with our previous DRB1 results, we also analyzed the association of DRB1-DQB1 haplotypes with IgAN. We found that the frequency of haplotype DRB1*090102-DQB1*060101 was significantly higher [odds ratio (OR) = 4.409, Pc = 0.016], whereas that of HLA-DRB1*070101-DQB1*020101 was significantly lower (OR = 0.194, Pc = 0.016) compared with healthy controls. Our study indicated that HLA-DQB1*060101 alleles may be a potential predictor of high-risk IgAN susceptibility in Chinese Han population.
authors.affiliation: Department of Nephrology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080, China.|Key Laboratory of Nephrology, Ministry of Health and Guangdong Province, Guangzhou, 510080, China.|Department of Nephrology, Sichuan Provincial People's Hospital, Chengdu, 610072, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.affiliation: Department of Nephrology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080, China.|Key Laboratory of Nephrology, Ministry of Health and Guangdong Province, Guangzhou, 510080, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Li
authors.affiliation: Department of Nephrology, Sichuan Provincial People's Hospital, Chengdu, 610072, China.
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Nephrology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080, China. yuxq@mail.sysu.edu.cn.|Key Laboratory of Nephrology, Ministry of Health and Guangdong Province, Guangzhou, 510080, China. yuxq@mail.sysu.edu.cn.
authors.forename: Xueqing
authors.initials: X
authors.lastname: Yu
mesh_terms: D000293:Adolescent; D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D002681:China; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005922:Glomerulonephritis, IGA / Q000235:genetics*; D059866:HLA-DQ beta-Chains / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D055815:Young Adult
chemical_list: D059866:HLA-DQ beta-Chains; C069051:HLA-DQB1 antigen
keywords: DQB1; IgA nephropathy; association study; haplotype; human leukocyte antigen (HLA)