title: Circulating levels of apoptotic markers and oxidative stress parameters in women with polycystic ovary syndrome: a case-controlled descriptive study.
abstract: BACKGROUND
  Apoptotic dysregulation plays a role in the pathogenesis of polycystic ovary syndrome (PCOS).
  
  
  OBJECTIVE
  To evaluate circulatory apoptotic markers and oxidative stress in patients with PCOS.
  
  
  METHODS
  Forty-four women with PCOS, and 44 healthy women as controls were enrolled in the study. Oxidative stress parameters and caspases levels were measured in serum.
  
  
  RESULTS
  The caspase 9 level was significantly lower and related with oxidant status in patients with PCOS, while the circulating levels of caspases 3 and 7 were statistically similar in both groups.
  
  
  CONCLUSIONS
  This study is the first report demonstrating the circulating levels of apoptotic markers and their relationship with oxidant status in PCOS.
  
  
  CONCLUSIONS
  The circulating caspase 9 and oxidant status might contribute to apoptotic dysregulation in PCOS.
authors.affiliation: a Department of Obstetrics and Gynecology, Medical Faculty , Harran University , Sanliurfa , Turkey.
authors.forename: Hacer
authors.identifier: http://orcid.org/0000-0003-0316-4900
authors.initials: H
authors.lastname: Uyanikoglu
authors.affiliation: b Department of Endocrinology, Medical Faculty , Harran University , Sanliurfa , Turkey.
authors.forename: Tevfik
authors.initials: T
authors.lastname: Sabuncu
authors.affiliation: b Department of Endocrinology, Medical Faculty , Harran University , Sanliurfa , Turkey.
authors.forename: Huseyin
authors.initials: H
authors.lastname: Dursun
authors.affiliation: c Department of Biochemistry, Medical Faculty , Harran University , Sanliurfa , Turkey.
authors.forename: Hatice
authors.initials: H
authors.lastname: Sezen
authors.affiliation: c Department of Biochemistry, Medical Faculty , Harran University , Sanliurfa , Turkey.
authors.forename: Nurten
authors.initials: N
authors.lastname: Aksoy
mesh_terms: D000293:Adolescent; D000328:Adult; D017209:Apoptosis; D015415:Biomarkers / Q000097:blood* / Q000378:metabolism; D016022:Case-Control Studies; D053148:Caspase 3; D053179:Caspase 7; D053453:Caspase 9 / Q000097:blood; D020169:Caspases / Q000097:blood*; D005260:Female; D006801:Humans; D018384:Oxidative Stress; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000378:metabolism / Q000473:pathology; D055815:Young Adult
chemical_list: D015415:Biomarkers; C505407:CASP3 protein, human; C505520:CASP7 protein, human; C506433:CASP9 protein, human; D053148:Caspase 3; D053179:Caspase 7; D053453:Caspase 9; D020169:Caspases
keywords: Polycystic ovary syndrome; apoptosis; caspase 9; oxidative stress