title: DisProt 7.0: a major update of the database of disordered proteins.
abstract: The Database of Protein Disorder (DisProt, URL: www.disprot.org) has been significantly updated and upgraded since its last major renewal in 2007. The current release holds information on more than 800 entries of IDPs/IDRs, i.e. intrinsically disordered proteins or regions that exist and function without a well-defined three-dimensional structure. We have re-curated previous entries to purge DisProt from conflicting cases, and also upgraded the functional classification scheme to reflect continuous advance in the field in the past 10 years or so. We define IDPs as proteins that are disordered along their entire sequence, i.e. entirely lack structural elements, and IDRs as regions that are at least five consecutive residues without well-defined structure. We base our assessment of disorder strictly on experimental evidence, such as X-ray crystallography and nuclear magnetic resonance (primary techniques) and a broad range of other experimental approaches (secondary techniques). Confident and ambiguous annotations are highlighted separately. DisProt 7.0 presents classified knowledge regarding the experimental characterization and functional annotations of IDPs/IDRs, and is intended to provide an invaluable resource for the research community for a better understanding structural disorder and for developing better computational tools for studying disordered proteins.
authors.affiliation: Department of Biomedical Sciences, University of Padova, I-35121 Padova, Italy.
authors.forename: Damiano
authors.initials: D
authors.lastname: Piovesan
authors.affiliation: Department of Biomedical Sciences, University of Padova, I-35121 Padova, Italy.|Institute of Biosciences and Medical Technology, University of Tampere, Finland.
authors.forename: Francesco
authors.initials: F
authors.lastname: Tabaro
authors.affiliation: Department of Biomedical Sciences, University of Padova, I-35121 Padova, Italy.
authors.forename: Ivan
authors.initials: I
authors.lastname: Mičetić
authors.affiliation: Department of Biomedical Sciences, University of Padova, I-35121 Padova, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Necci
authors.affiliation: Department of Biomedical Sciences, University of Padova, I-35121 Padova, Italy.
authors.forename: Federica
authors.initials: F
authors.lastname: Quaglia
authors.affiliation: Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, 46202 Indianapolis, IN, USA.
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Oldfield
authors.affiliation: Department of Woman and Child Health, University of Padova, I-35128 Padova, Italy.
authors.forename: Maria Cristina
authors.initials: MC
authors.lastname: Aspromonte
authors.affiliation: Conway Institute of Biomolecular & Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland.|Ireland UCD School of Medicine & Medical Science, University College Dublin, Belfield, Dublin 4, Ireland.
authors.forename: Norman E
authors.initials: NE
authors.lastname: Davey
authors.affiliation: Centre for Multidisciplinary Research, Institute of Nuclear Sciences Vinca, University of Belgrade, 11001 Belgrade, Serbia.
authors.forename: Radoslav
authors.initials: R
authors.lastname: Davidović
authors.affiliation: MTA-ELTE Lendület Bioinformatics Research Group, Department of Biochemistry, Eötvös Loránd University, 1/c Pázmány Péter sétány, 1117 Budapest, Hungary.|Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, PO Box 7,H-1518 Budapest, Hungary.
authors.forename: Zsuzsanna
authors.initials: Z
authors.lastname: Dosztányi
authors.affiliation: Department of Biochemistry and Biophysics and Science for Life Laboratory, Stockholm University, Box 1031, 17121 Solna, Sweden.
authors.forename: Arne
authors.initials: A
authors.lastname: Elofsson
authors.affiliation: Department of Woman and Child Health, University of Padova, I-35128 Padova, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Gasparini
authors.affiliation: Department of Biomedical Sciences, University of Padova, I-35121 Padova, Italy.|Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, PO Box 7,H-1518 Budapest, Hungary.
authors.forename: András
authors.initials: A
authors.lastname: Hatos
authors.affiliation: Centre de Recherche en Biologie cellulaire de Montpellier (CRBM), UMR 5237 CNRS, Université Montpellier 1919 Route de Mende, Cedex 5, Montpellier 34293, France.|Institut de Biologie Computationnelle (IBC), Montpellier 34095, France.|University ITMO, Institute of Bioengineering, St. Petersburg 197101, Russia.
authors.forename: Andrey V
authors.initials: AV
authors.lastname: Kajava
authors.affiliation: Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, PO Box 7,H-1518 Budapest, Hungary.|Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, UK.
authors.forename: Lajos
authors.initials: L
authors.lastname: Kalmar
authors.affiliation: Department of Woman and Child Health, University of Padova, I-35128 Padova, Italy.
authors.forename: Emanuela
authors.initials: E
authors.lastname: Leonardi
authors.affiliation: Structural Biology Brussels, Vrije Universiteit Brussel (VUB), Brussels 1050, Belgium.|Structural Biology Research Center (SBRC), Flanders Institute for Biotechnology (VIB), Brussels 1050, Belgium.
authors.forename: Tamas
authors.initials: T
authors.lastname: Lazar
authors.affiliation: Biomolecular Structure and Function Group, Instituto de Biologia Molecular e Celular (IBMC) and Instituto de Investigação e Inovação em Saúde (i3S), Universidade do Porto, 4200-135 Porto, Portugal.
authors.forename: Sandra
authors.initials: S
authors.lastname: Macedo-Ribeiro
authors.affiliation: Structural Biology Brussels, Vrije Universiteit Brussel (VUB), Brussels 1050, Belgium.|Structural Biology Research Center (SBRC), Flanders Institute for Biotechnology (VIB), Brussels 1050, Belgium.
authors.forename: Mauricio
authors.initials: M
authors.lastname: Macossay-Castillo
authors.affiliation: Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, PO Box 7,H-1518 Budapest, Hungary.
authors.forename: Attila
authors.initials: A
authors.lastname: Meszaros
authors.affiliation: Department of Biomedical Sciences, University of Padova, I-35121 Padova, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Minervini
authors.affiliation: Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, PO Box 7,H-1518 Budapest, Hungary.
authors.forename: Nikoletta
authors.initials: N
authors.lastname: Murvai
authors.affiliation: Departament de Bioquimica i Biologia Molecular and Institut de Biotecnologia i Biomedicina, Universitat Autònoma de Barcelona, Bellaterra 08193, Spain.
authors.forename: Jordi
authors.initials: J
authors.lastname: Pujols
authors.affiliation: Centre de Recherche en Biologie cellulaire de Montpellier (CRBM), UMR 5237 CNRS, Université Montpellier 1919 Route de Mende, Cedex 5, Montpellier 34293, France.|Institut de Biologie Computationnelle (IBC), Montpellier 34095, France.
authors.forename: Daniel B
authors.initials: DB
authors.lastname: Roche
authors.affiliation: Aix-Marseille Univ, CNRS, AFMB, UMR 7257, Marseille, France.
authors.forename: Edoardo
authors.initials: E
authors.lastname: Salladini
authors.affiliation: Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, PO Box 7,H-1518 Budapest, Hungary.
authors.forename: Eva
authors.initials: E
authors.lastname: Schad
authors.affiliation: Aix-Marseille Univ, CNRS, AFMB, UMR 7257, Marseille, France.
authors.forename: Antoine
authors.initials: A
authors.lastname: Schramm
authors.affiliation: Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, PO Box 7,H-1518 Budapest, Hungary.
authors.forename: Beata
authors.initials: B
authors.lastname: Szabo
authors.affiliation: Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, PO Box 7,H-1518 Budapest, Hungary.
authors.forename: Agnes
authors.initials: A
authors.lastname: Tantos
authors.affiliation: Department of Biomedical Sciences, University of Padova, I-35121 Padova, Italy.|CNR Institute of Neurosceince, I-35121 Padova, Italy.
authors.forename: Fiorella
authors.initials: F
authors.lastname: Tonello
authors.affiliation: Department of Biochemistry and Biophysics and Science for Life Laboratory, Stockholm University, Box 1031, 17121 Solna, Sweden.
authors.forename: Konstantinos D
authors.initials: KD
authors.lastname: Tsirigos
authors.affiliation: Centre for Multidisciplinary Research, Institute of Nuclear Sciences Vinca, University of Belgrade, 11001 Belgrade, Serbia.
authors.forename: Nevena
authors.initials: N
authors.lastname: Veljković
authors.affiliation: Departament de Bioquimica i Biologia Molecular and Institut de Biotecnologia i Biomedicina, Universitat Autònoma de Barcelona, Bellaterra 08193, Spain.
authors.forename: Salvador
authors.initials: S
authors.lastname: Ventura
authors.affiliation: Structural Biology Brussels, Vrije Universiteit Brussel (VUB), Brussels 1050, Belgium.|Structural Biology Research Center (SBRC), Flanders Institute for Biotechnology (VIB), Brussels 1050, Belgium.|Interuniversity Institute of Bioinformatics in Brussels (IB2), ULB-VUB, Brussels 1050, Belgium.
authors.forename: Wim
authors.identifier: 0000-0001-7470-4324
authors.initials: W
authors.lastname: Vranken
authors.affiliation: Department of Biochemistry and Biophysics and Science for Life Laboratory, Stockholm University, Box 1031, 17121 Solna, Sweden.
authors.forename: Per
authors.initials: P
authors.lastname: Warholm
authors.affiliation: Laboratory of Structural Dynamics, Stability and Folding of Proteins, Institute of Cytology, Russian Academy of Sciences, 194064 St. Petersburg, Russia.|Department of Molecular Medicine and USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.
authors.forename: Vladimir N
authors.initials: VN
authors.lastname: Uversky
authors.affiliation: Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, 46202 Indianapolis, IN, USA.
authors.forename: A Keith
authors.initials: AK
authors.lastname: Dunker
authors.affiliation: Aix-Marseille Univ, CNRS, AFMB, UMR 7257, Marseille, France Sonia.Longhi@afmb.univ-mrs.fr.
authors.forename: Sonia
authors.initials: S
authors.lastname: Longhi
authors.affiliation: Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, PO Box 7,H-1518 Budapest, Hungary ptompa@vub.ac.be.|Structural Biology Brussels, Vrije Universiteit Brussel (VUB), Brussels 1050, Belgium.|Structural Biology Research Center (SBRC), Flanders Institute for Biotechnology (VIB), Brussels 1050, Belgium.
authors.forename: Peter
authors.initials: P
authors.lastname: Tompa
authors.affiliation: Department of Biomedical Sciences, University of Padova, I-35121 Padova, Italy silvio.tosatto@unipd.it.|CNR Institute of Neurosceince, I-35121 Padova, Italy.
authors.forename: Silvio C E
authors.identifier: 0000-0003-4525-7793
authors.initials: SC
authors.lastname: Tosatto
mesh_terms: D000818:Animals; D018360:Crystallography, X-Ray; D030562:Databases, Protein; D031541:Fluorescence Resonance Energy Transfer; D005544:Forecasting; D005568:Forms and Records Control; D006801:Humans; D064267:Intrinsically Disordered Proteins / Q000145:classification; D019906:Nuclear Magnetic Resonance, Biomolecular; D011487:Protein Conformation
chemical_list: D064267:Intrinsically Disordered Proteins