title: Invasive pneumococcal disease: From a tertiary care hospital in the post-vaccine era.
abstract: A breakthrough infection occurring with 13-valent pneumococcal conjugate vaccine (PCV13) in Turkey are previously described. A breakthrough infection is defined as IPD in a child who had received ≥ 1 PCV-7 or PCV-13 and for which the pneumococcal isolate was a vaccine serotype. During one year period, among 6 patients with invasive pneumococcal infection, 2 patients were considered to have a vaccine failure with serotype 19F. Antibiotic resistance results were remarkable; macrolide resistance were observed in all strains except one, and high and intermediate penicillin resistance were determined in 2 strains.
authors.affiliation: a Department of Pediatric Infectious Diseases , Hacettepe University Faculty of Medicine , Ankara , Turkey.
authors.forename: Sevgen
authors.initials: S
authors.lastname: Tanır Basaranoglu
authors.affiliation: a Department of Pediatric Infectious Diseases , Hacettepe University Faculty of Medicine , Ankara , Turkey.
authors.forename: Eda
authors.initials: E
authors.lastname: Karadag Oncel
authors.affiliation: a Department of Pediatric Infectious Diseases , Hacettepe University Faculty of Medicine , Ankara , Turkey.
authors.forename: Kubra
authors.initials: K
authors.lastname: Aykac
authors.affiliation: a Department of Pediatric Infectious Diseases , Hacettepe University Faculty of Medicine , Ankara , Turkey.
authors.forename: Yasemin
authors.initials: Y
authors.lastname: Ozsurekci
authors.affiliation: a Department of Pediatric Infectious Diseases , Hacettepe University Faculty of Medicine , Ankara , Turkey.
authors.forename: Ali Bülent
authors.initials: AB
authors.lastname: Cengiz
authors.affiliation: a Department of Pediatric Infectious Diseases , Hacettepe University Faculty of Medicine , Ankara , Turkey.
authors.forename: Ates
authors.initials: A
authors.lastname: Kara
authors.affiliation: a Department of Pediatric Infectious Diseases , Hacettepe University Faculty of Medicine , Ankara , Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Ceyhan
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D016470:Bacteremia / Q000175:diagnosis / Q000382:microbiology / Q000517:prevention & control; D002648:Child; D002675:Child, Preschool; D024881:Drug Resistance, Bacterial; D006801:Humans; D007223:Infant; D008297:Male; D016920:Meningitis, Bacterial / Q000175:diagnosis / Q000382:microbiology / Q000517:prevention & control; D011008:Pneumococcal Infections / Q000175:diagnosis* / Q000382:microbiology* / Q000517:prevention & control; D022242:Pneumococcal Vaccines / Q000276:immunology*; D065288:Serogroup; D013296:Streptococcus pneumoniae / Q000145:classification / Q000187:drug effects / Q000302:isolation & purification; D062606:Tertiary Care Centers; D017211:Treatment Failure; D014421:Turkey
chemical_list: D000900:Anti-Bacterial Agents; D022242:Pneumococcal Vaccines
keywords: Streptococcus pneumoniae; antibiotic resistance; breakthrough infection; invasive pneumococcus disease; surveillance; vaccination; vaccine failure