title: Nuclear PKM2 expression, an independent risk factor for ER after curative resection of hepatocellular carcinoma.
abstract: Surgical resection, providing a long-term survival of hepatocellular carcinoma (HCC) patients, is regarded as one of the standard curative treatments of HCC if the tumor is resectable. However, 50% patients develop early recurrence (ER) during the first two years after operation, which are more diffuse and rarely treatable with unsatisfactory long-term survival. Unfortunately, the underlying mechanisms of ER after curative resection and the molecular markers with predictive and prognostic significance have never been identified yet. Recent studies reveal that pyruvate kinase M2 (PKM2) levels were correlated with overall survival and disease-free survival in patients with HCC. The present study was aimed to investigate the correlation between the expression of PKM2 and ER. Our findings demonstrated that not the total PKM2 expression but the nuclear PKM2 expression as an independent risk factor for ER after curative resection, and could be a promising intervention target following curative resection for HCC patients.
authors.affiliation: Department of Pharmacy, Nanjing University of Chinese Medicine Hanlin College, Taizhou 225300, China.
authors.forename: Fangtian
authors.initials: F
authors.lastname: Fan
authors.affiliation: College of Pharmacy, Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chine-se Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, China; Department of Pharmacy, Yancheng Health Vocational and Technical College, Yancheng 224005, China.
authors.forename: Hongyan
authors.initials: H
authors.lastname: Wu
authors.affiliation: College of Pharmacy, Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chine-se Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, China.
authors.forename: Zhaoguo
authors.initials: Z
authors.lastname: Liu
authors.affiliation: College of Pharmacy, Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chine-se Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, China.
authors.forename: Xianbang
authors.initials: X
authors.lastname: Hou
authors.affiliation: College of Pharmacy, Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chine-se Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, China; Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine (TCM), Prevention and Treatment of Tumor, Nanjing University of Chinese Medicine, Nanjing 210023, China.
authors.forename: Wenxin
authors.initials: W
authors.lastname: Chen
authors.affiliation: College of Pharmacy, Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chine-se Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, China; Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine (TCM), Prevention and Treatment of Tumor, Nanjing University of Chinese Medicine, Nanjing 210023, China.
authors.forename: Aiyun
authors.initials: A
authors.lastname: Wang
authors.affiliation: College of Pharmacy, Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chine-se Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, China; Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine (TCM), Prevention and Treatment of Tumor, Nanjing University of Chinese Medicine, Nanjing 210023, China. Electronic address: profyinlu@163.com.
authors.forename: Yin
authors.initials: Y
authors.lastname: Lu
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D006528:Carcinoma, Hepatocellular / Q000201:enzymology* / Q000473:pathology / Q000601:surgery*; D002352:Carrier Proteins / Q000032:analysis*; D002467:Cell Nucleus / Q000201:enzymology*; D049109:Cell Proliferation; D005260:Female; D056945:Hep G2 Cells; D006498:Hepatectomy / Q000009:adverse effects*; D006801:Humans; D053208:Kaplan-Meier Estimate; D008113:Liver Neoplasms / Q000201:enzymology* / Q000473:pathology / Q000601:surgery*; D008297:Male; D008565:Membrane Proteins / Q000032:analysis*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D011237:Predictive Value of Tests; D012307:Risk Factors; D013963:Thyroid Hormones / Q000032:analysis*; D013997:Time Factors; D016896:Treatment Outcome; D000097810:Thyroid Hormone-Binding Proteins
chemical_list: D014408:Biomarkers, Tumor; D002352:Carrier Proteins; D008565:Membrane Proteins; D013963:Thyroid Hormones; D000097810:Thyroid Hormone-Binding Proteins
keywords: Early recurrence (ER); Hepatocellular carcinoma (HCC); Nuclear PKM2