title: EZH2 overexpression is associated with poor prognosis in patients with glioma.
abstract: Previous studies have investigated the prognostic value of enhancer of zeste homolog 2 (EZH2) expression in patients with glioma but conclude contradictory results. We aimed to comprehensively evaluate the prognostic role of EZH2 in glioma by meta-analysis. The databases of PubMed, Embase and Web of Science were searched. Hazard ratio (HR) and 95% confidence interval (CI) were combined to assess the association between EZH2 and overall survival (OS) as well as progression-free survival (PFS). Odd ratio (OR) and 95% CI were calculated to investigate the relevance of EZH2 on clinical factors. Six studies with 575 patients were included for meta-analysis. The results showed that EZH2 overexpression was correlated with poor OS (n = 6, HR = 2.23, 95% CI: 1.56-3.19, p < 0.001) and PFS (n = 3, HR = 2.23, 95% CI: 1.56-3.19, p < 0.001). Subgroup analysis showed that EZH2 had enhanced prognostic value in Asian patients, for WHO grade I-IV and when using immunohistochemistry (IHC) method. In addition, EZH2 was associated with KPS score < 80. No evidence of publication bias was found in this meta-analysis. In conclusion, the present study showed that EZH2 was a potential prognostic marker for poor OS, PFS and lower KPS score in glioma patients.
authors.affiliation: Department of Neurosurgery, Chinese PLA General Hospital, Beijing 100853, China.
authors.forename: Yanyang
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Neurosurgery, Chinese PLA General Hospital, Beijing 100853, China.
authors.forename: Xinguang
authors.initials: X
authors.lastname: Yu
authors.affiliation: Department of Neurosurgery, Chinese PLA General Hospital, Beijing 100853, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Chen
authors.affiliation: Department of Neurosurgery, Chinese PLA General Hospital, Beijing 100853, China.
authors.forename: Zhibin
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Neurosurgery, Chinese PLA General Hospital, Beijing 100853, China.
authors.forename: Shiyu
authors.initials: S
authors.lastname: Feng
mesh_terms: D000367:Age Factors; D014408:Biomarkers, Tumor; D000071221:Enhancer of Zeste Homolog 2 Protein / Q000235:genetics*; D015870:Gene Expression; D005910:Glioma / Q000235:genetics* / Q000401:mortality* / Q000473:pathology; D006801:Humans; D016017:Odds Ratio; D011379:Prognosis; D017594:Publication Bias; D012737:Sex Factors
chemical_list: D014408:Biomarkers, Tumor; C498409:EZH2 protein, human; D000071221:Enhancer of Zeste Homolog 2 Protein
keywords: EZH2; biomarker; glioma; prognosis