title: Effect of Acute Noise Exposure on Salivary Cortisol: A Randomized Controlled Trial.
abstract: Cardiovascular adverse effects are interesting aspects of occupational noise exposure. One possible mechanism of these effects is an alternation in hypothalamic-pituitary-adrenal axis. Our aim was to measure salivary cortisol response to relatively high-intensity noise exposure in a controlled randomized trial study. We exposed 50 male volunteers to 90 dBA noise for 20 minutes and compared their level of salivary cortisol with 50 non-exposed controls. Salivary samples obtained before and after exposure. Before intervention means (SD) salivary cortisol level were 3.24 (0.47)ng/ml and 3.25 (0.41)ng/ml for exposed and non-exposed groups respectively. Mean salivary cortisol level increased to 4.17 ng/mlafter intervention in exposure group. This increment was statistically significant (P=0.00). Mean salivary cortisol level of the non-exposed group had statistically non-significant decrement after this period (0.2 ng/ml). The difference between salivary cortisol level of non-exposed and exposed groups after the intervention was statistically significant. Noise exposure may affect the hypothalamic-pituitary-adrenal axis activity, and this may be one of the mechanisms of noise exposure cardiovascular effects.
authors.affiliation: Occupational Diseases Research Center, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Gholamreza
authors.initials: G
authors.lastname: Pouryaghoub
authors.affiliation: Department of Occupational Medicine, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Ramin
authors.initials: R
authors.lastname: Mehrdad
authors.affiliation: Department of Occupational Medicine, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Alireza
authors.initials: A
authors.lastname: Valipouri
mesh_terms: D000328:Adult; D006801:Humans; D006854:Hydrocortisone / Q000032:analysis*; D007030:Hypothalamo-Hypophyseal System; D008297:Male; D009622:Noise / Q000009:adverse effects*; D016273:Occupational Exposure; D010913:Pituitary-Adrenal System; D012463:Saliva / Q000737:chemistry*; D016037:Single-Blind Method
chemical_list: D006854:Hydrocortisone
keywords: Cardiovascular; Hypertension; Noise; Salivary cortisol