title: Bacterial Colonization in Hidradenitis Suppurativa/Acne Inversa: A Cross-sectional Study of 50 Patients and Review of the Literature.
abstract: It is unclear whether bacterial colonization in hidradenitis suppurativa/acne inversa (HS) comprises a primary cause, triggering factor or secondary phenomenon of the disease pathogenesis. Furthermore, the connection between certain bacterial species, the disease severity and its localization is unknown. Bacterial species were isolated from HS lesions to reveal a potential correlation with localization and disease severity. Ninety swab tests were prospectively obtained from 90 HS lesions of 50 consecutive patients. The material was cultured under aerobic and anaerobic conditions. The identified species were statistically correlated with Hurley stage and localization of the lesions. The most prevalent isolates were reported. Hurley stage significantly correlated with disease localization. Particular bacterial species were associated with "extended" disease and Hurley III stage with the detection of both aerobic and anaerobic bacteria and with a higher number of species. The presence of bacterial species is dependent on the local milieu, which correlates with the localization of the disease, its clinical manifestations and its extension.
authors.affiliation: Departments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Dessau, Germany.
authors.forename: Georgios
authors.initials: G
authors.lastname: Nikolakis
authors.forename: Aikaterini I
authors.initials: AI
authors.lastname: Liakou
authors.forename: Stefanos
authors.initials: S
authors.lastname: Bonovas
authors.forename: Holger
authors.initials: H
authors.lastname: Seltmann
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Bonitsis
authors.forename: Olivier
authors.initials: O
authors.lastname: Join-Lambert
authors.forename: Thomas
authors.initials: T
authors.lastname: Wild
authors.forename: Ioannis
authors.initials: I
authors.lastname: Karagiannidis
authors.forename: Silvia
authors.initials: S
authors.lastname: Zolke-Fischer
authors.forename: Klaus
authors.initials: K
authors.lastname: Langner
authors.forename: Christos C
authors.initials: CC
authors.lastname: Zouboulis
mesh_terms: D000328:Adult; D001050:Apocrine Glands / Q000382:microbiology*; D001419:Bacteria / Q000145:classification / Q000254:growth & development* / Q000302:isolation & purification; D001424:Bacterial Infections / Q000175:diagnosis / Q000382:microbiology*; D058491:Bacterial Load; D016009:Chi-Square Distribution; D003430:Cross-Sectional Studies; D005260:Female; D017497:Hidradenitis Suppurativa / Q000175:diagnosis / Q000382:microbiology*; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D011379:Prognosis; D011446:Prospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index