title: Fabrication of functional hollow microspheres constructed from MOF shells: Promising drug delivery systems with high loading capacity and targeted transport.
abstract: An advanced multifunctional, hollow metal-organic framework (MOF) drug delivery system with a high drug loading level and targeted delivery was designed and fabricated for the first time and applied to inhibit tumour cell growth. This hollow MOF targeting drug delivery system was prepared via a simple post-synthetic surface modification procedure, starting from hollow ZIF-8 successfully obtained for the first time via a mild phase transformation under solvothermal conditions. As a result, the hollow ZIF-8 exhibits a higher loading capacity for the model anticancer drug 5-fluorouracil (5-FU). Subsequently, 5-FU-loaded ZIF-8 was encapsulated into polymer layers (FA-CHI-5-FAM) with three components: a chitosan (CHI) backbone, the imaging agent 5-carboxyfluorescein (5-FAM), and the targeting reagent folic acid (FA). Thus, an advanced drug delivery system, ZIF-8/5-FU@FA-CHI-5-FAM, was fabricated. A cell imaging assay demonstrated that ZIF-8/5-FU@FA-CHI-5-FAM could target and be taken up by MGC-803 cells. Furthermore, the as-prepared ZIF-8/5-FU@FA-CHI-5-FAM exhibited stronger cell growth inhibitory effects on MGC-803 cells because of the release of 5-FU, as confirmed by a cell viability assay. In addition, a drug release experiment in vitro indicated that ZIF-8/5-FU@FA-CHI-5-FAM exhibited high loading capacity (51%) and a sustained drug release behaviour. Therefore, ZIF-8/5-FU@FA-CHI-5-FAM could provide targeted drug transportation, imaging tracking and localized sustained release.
authors.affiliation: College of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot, 010021, P.R. China.
authors.forename: Xuechuan
authors.initials: X
authors.lastname: Gao
authors.affiliation: College of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot, 010021, P.R. China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Hai
authors.affiliation: College of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot, 010021, P.R. China.
authors.forename: Huricha
authors.initials: H
authors.lastname: Baigude
authors.affiliation: College of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot, 010021, P.R. China.
authors.forename: Weihua
authors.initials: W
authors.lastname: Guan
authors.affiliation: College of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot, 010021, P.R. China.
authors.forename: Zhiliang
authors.initials: Z
authors.lastname: Liu
mesh_terms: D001692:Biological Transport; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D048271:Chitosan / Q000737:chemistry; D016503:Drug Delivery Systems; D065546:Drug Liberation; D005452:Fluoresceins / Q000737:chemistry; D005472:Fluorouracil / Q000494:pharmacology; D005492:Folic Acid / Q000494:pharmacology; D006801:Humans; D000073396:Metal-Organic Frameworks / Q000737:chemistry*; D008863:Microspheres; D053758:Nanoparticles / Q000737:chemistry; D013050:Spectrometry, Fluorescence; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction
chemical_list: D005452:Fluoresceins; D000073396:Metal-Organic Frameworks; C045132:4-carboxyfluorescein; D048271:Chitosan; D005492:Folic Acid; D005472:Fluorouracil