title: 99mTc-HMPAO perfusion SPECT/CT in the diagnosis of brain death.
abstract: This report describes a case of brain death (BD) evaluated by 99mTc-hexamethylpropylene amine oxime (HMPAO) single photon emission tomography/computed tomography (SPECT/CT). A 16-year-old boy with a history of rapid unexpected brain herniation due to pilocytic astrocytoma underwent 99mTc-HMPAO SPECT/CT for evaluation of brain death in the context of organ donation. Flow images demonstrated lack of blood flow to the brain, and delayed images showed absence of demonstrable radionuclide activity within the brain. SPECT/CT confirmed absence of tracer accumulation, and was deemed helpful for evaluation of the brain stem. 99mTc-HMPAO SPECT/CT is a valuable tool enabling imaging-based confirmation of BD.
authors.affiliation: Hannover Medical School. Derlin.Thorsten@mh-hannover.de.
authors.forename: Thorsten
authors.initials: T
authors.lastname: Derlin
authors.forename: Desiree
authors.initials: D
authors.lastname: Weiberg
mesh_terms: D000293:Adolescent; D001921:Brain / Q000098:blood supply / Q000000981:diagnostic imaging; D001926:Brain Death / Q000000981:diagnostic imaging*; D001933:Brain Stem / Q000098:blood supply / Q000000981:diagnostic imaging; D002560:Cerebrovascular Circulation; D059907:Functional Neuroimaging; D006801:Humans; D008297:Male; D019275:Radiopharmaceuticals; D000072098:Single Photon Emission Computed Tomography Computed Tomography; D019690:Technetium Tc 99m Exametazime
chemical_list: D019275:Radiopharmaceuticals; D019690:Technetium Tc 99m Exametazime
keywords: HMPAO; SPECT; SPECT/CT; brain death; perfusion imaging