title: Ultrasound-guided core needle biopsy of cervical lymph nodes in the diagnosis of toxoplasmosis.
abstract: BACKGROUND
  Our study investigates whether the histopathological features of toxoplasmic lymphadenitis (TL), specifically noncaseating microgranuloma and follicular hyperplasia, can be obtained by sonographic-guided core needle biopsy (CNB) of cervical lymph nodes.
  
  
  METHODS
  Thirty-two patients seen from June 2014 to March 2015 were positive for toxoplasma immunoglobulin M antibody. Among those patients, 21 underwent CNB of a cervical lymph node and were enrolled in this study. The pathologic findings were reviewed.
  
  
  RESULTS
  Twenty-nine lymph nodes in 21 patients were sampled. Eighteen of the 21 (86%) patients had a microgranuloma without caseating necrosis or giant cells, and all 21 (100%) patients had follicular hyperplasia.
  
  
  CONCLUSIONS
  The histologic findings of TL were detected by sonographic-guided CNB, which can be used as part of the first line of investigation in patients with unexplained cervical adenopathy. © 2016 Wiley Periodicals, Inc. J Clin Ultrasound 45:192-196, 2017.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Withsim Clinic, Gyeonggi-do, Korea.
authors.forename: Woojin
authors.initials: W
authors.lastname: Cho
authors.affiliation: KMK Pathology Laboratory, Seoul, Korea.
authors.forename: Min Kyung
authors.initials: MK
authors.lastname: Kim
authors.affiliation: Department of Radiology, Withsim Clinic, Gyeonggi-do, Korea.
authors.forename: Jung Suk
authors.initials: JS
authors.lastname: Sim
mesh_terms: D000293:Adolescent; D000328:Adult; D062005:Biopsy, Large-Core Needle; D002648:Child; D005260:Female; D006801:Humans; D061705:Image-Guided Biopsy / Q000379:methods; D008198:Lymph Nodes / Q000469:parasitology* / Q000473:pathology*; D008206:Lymphatic Diseases / Q000175:diagnosis* / Q000469:parasitology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009333:Neck; D014123:Toxoplasmosis / Q000175:diagnosis* / Q000473:pathology; D018084:Ultrasonography, Interventional / Q000379:methods*; D055815:Young Adult
keywords: core needle biopsy; lymphadenopathy; toxoplasmosis; ultrasound