title: Gut Hormone Regulation and Secretion via FFA1 and FFA4.
abstract: The digestion, absorption and utilisation of dietary triglycerides are controlled by gut hormones, released from enteroendocrine cells along the length of the gastrointestinal tract. Major players in the detection of ingested lipids are the free fatty acid receptors FFA1 and FFA4, which are highly expressed on enteroendocrine cells. These receptors are activated when free fatty acids (FFA) are absorbed across the intestinal epithelium, and provide a dynamic hormonal signal indicating that lipids are arriving in the bloodstream from the gut. This review addresses our current knowledge of how ingested triglycerides modulate gut hormone release via FFA1 and FFA4.
authors.affiliation: Metabolic Research Laboratories and MRC Metabolic Diseases Unit, WT-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK. fmg23@cam.ac.uk.
authors.forename: Fiona M
authors.initials: FM
authors.lastname: Gribble
authors.affiliation: Metabolic Research Laboratories and MRC Metabolic Diseases Unit, WT-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK.
authors.forename: Eleftheria
authors.initials: E
authors.lastname: Diakogiannaki
authors.affiliation: Metabolic Research Laboratories and MRC Metabolic Diseases Unit, WT-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK.
authors.forename: Frank
authors.initials: F
authors.lastname: Reimann
mesh_terms: D000818:Animals; D002460:Cell Line; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D005768:Gastrointestinal Hormones / Q000378:metabolism*; D052216:Glucagon-Like Peptide 1 / Q000502:physiology; D006801:Humans; D054795:Incretins / Q000502:physiology; D043562:Receptors, G-Protein-Coupled / Q000502:physiology*; D015398:Signal Transduction
chemical_list: C473034:FFAR1 protein, human; C519853:FFAR4 protein, human; D005230:Fatty Acids, Nonesterified; D005768:Gastrointestinal Hormones; D054795:Incretins; D043562:Receptors, G-Protein-Coupled; D052216:Glucagon-Like Peptide 1
keywords: CCK; FFA1; FFA4; GIP; GLP-1; Ghrelin; Incretin