title: Near-infrared Light Responsive Polymeric Nanocomposites for Cancer Therapy.
abstract: Inorganic nanoparticles, which can absorb and convert near infrared (NIR) light to heat to ablate cancer cells, have been widely investigated in photothermal therapy. However, the inherent poor solubility and acute systemic toxicity of these inorganic particles hinder their application in clinical practice. Polymeric nanocomposites materials containing both inorganic nanoparticles and polymers could be harnessed to achieve enhanced photothermal therapeutic effect as well as improved biocompatibility and multi-responsiveness. Synergistic chemo-photothermal efficacy towards cancer cells and tumor tissue can thus be realized through such multi-functional and multi-responsive polymeric nanocomposites. In this review, the recent developments in polymeric nanocomposites based on different types of inorganic nanoparticles (i.e. gold, carbon nanotube, graphene, and upconversion nanoparticles) for NIR-triggered cancer therapy are summarized.
authors.affiliation: College of Chemistry and Molecular Science, Wuhan University, Wuhan, Hubei 430072, China.
authors.forename: Cong
authors.initials: C
authors.lastname: Min
authors.affiliation: College of Chemistry and Molecular Science, Wuhan University, Wuhan, Hubei 430072, China.
authors.forename: Xueqing
authors.initials: X
authors.lastname: Zou
authors.affiliation: College of Chemistry and Molecular Science, Wuhan University, Wuhan, Hubei 430072, China.
authors.forename: Quanzhu
authors.initials: Q
authors.lastname: Yang
authors.affiliation: College of Chemistry and Molecular Science, Wuhan University, Wuhan, Hubei 430072, China.
authors.forename: Liqiong
authors.initials: L
authors.lastname: Liao
authors.affiliation: Institute of Electronic Paper Display, South China Academy of Advanced Optoelectronics, South China Normal University, Guangzhou 510006, China.
authors.forename: Guofu
authors.initials: G
authors.lastname: Zhou
authors.affiliation: College of Chemistry and Molecular Science, Wuhan University, Wuhan, Hubei 430072, China.
authors.forename: Lijian
authors.initials: L
authors.lastname: Liu
mesh_terms: D006801:Humans; D007259:Infrared Rays; D053761:Nanocomposites; D009369:Neoplasms / Q000188:drug therapy*; D011108:Polymers / Q000627:therapeutic use*
chemical_list: D011108:Polymers
keywords: Chemotherapy; Near infrared; Photothermal therapy; Polymeric nanocomposites.