title: Long-range and wide field of view optical coherence tomography forin vivo3D imaging of large volume object based on akinetic programmable swept source.
abstract: Current optical coherence tomography (OCT) imaging suffers from short ranging distance and narrow imaging field of view (FOV). There is growing interest in searching for solutions to these limitations in order to expand further in vivo OCT applications. This paper describes a solution where we utilize an akinetic swept source for OCT implementation to enable ~10 cm ranging distance, associated with the use of a wide-angle camera lens in the sample arm to provide a FOV of ~20 x 20 cm2. The akinetic swept source operates at 1300 nm central wavelength with a bandwidth of 100 nm. We propose an adaptive calibration procedure to the programmable akinetic light source so that the sensitivity of the OCT system over ~10 cm ranging distance is substantially improved for imaging of large volume samples. We demonstrate the proposed swept source OCT system for in vivo imaging of entire human hands and faces with an unprecedented FOV (up to 400 cm2). The capability of large-volume OCT imaging with ultra-long ranging and ultra-wide FOV is expected to bring new opportunities for in vivo biomedical applications.
authors.affiliation: University of Washington, Department of Bioengineering, Seattle, Washington 98195, USA.
authors.forename: Shaozhen
authors.initials: S
authors.lastname: Song
authors.affiliation: University of Washington, Department of Bioengineering, Seattle, Washington 98195, USA.
authors.forename: Jingjiang
authors.initials: J
authors.lastname: Xu
authors.affiliation: University of Washington, Department of Bioengineering, Seattle, Washington 98195, USA.
authors.forename: Ruikang K
authors.initials: RK
authors.lastname: Wang
keywords: (110.4500) Optical coherence tomography; (140.3600) Lasers, tunable; (170.0110) Imaging systems; (170.3880) Medical and biological imaging