title: Sleep & metabolism: The multitasking ability of lateral hypothalamic inhibitory circuitries.
abstract: The anatomical and functional mapping of lateral hypothalamic circuits has been limited by the numerous cell types and complex, yet unclear, connectivity. Recent advances in functional dissection of input-output neurons in the lateral hypothalamus have identified subset of inhibitory cells as crucial modulators of both sleep-wake states and metabolism. Here, we summarize these recent studies and discuss the multi-tasking functions of hypothalamic circuitries in integrating sleep and metabolism in the mammalian brain.
authors.affiliation: Department of Neurology and Department of Clinical Research, Inselspital University Hospital, University of Bern, Bern, Switzerland; Department of Psychiatry, McGill University, Montreal, QC, Canada.
authors.forename: Carolina Gutierrez
authors.initials: CG
authors.lastname: Herrera
authors.affiliation: Leibniz Institute for Molecular Pharmacology (FMP)/NeuroCure Cluster of Excellence, Berlin, Germany.
authors.forename: Alexey
authors.initials: A
authors.lastname: Ponomarenko
authors.affiliation: Leibniz Institute for Molecular Pharmacology (FMP)/NeuroCure Cluster of Excellence, Berlin, Germany.
authors.forename: Tatiana
authors.initials: T
authors.lastname: Korotkova
authors.affiliation: The Francis Crick Institute, Mill Hill Laboratory, London NW7 1AA, UK; Department of Developmental Neurobiology, King's College London, London WC2R 2LS, UK.
authors.forename: Denis
authors.initials: D
authors.lastname: Burdakov
authors.affiliation: Department of Neurology and Department of Clinical Research, Inselspital University Hospital, University of Bern, Bern, Switzerland; Department of Psychiatry, McGill University, Montreal, QC, Canada. Electronic address: antoine.adamantidis@dkf.unibe.ch.
authors.forename: Antoine
authors.initials: A
authors.lastname: Adamantidis
mesh_terms: D000818:Animals; D001143:Arousal / Q000502:physiology; D006801:Humans; D007026:Hypothalamic Area, Lateral / Q000502:physiology*; D008660:Metabolism / Q000502:physiology*; D012890:Sleep / Q000502:physiology*
keywords: Food intake; GABA; Histamine; Hypocretin; Melanin concentrating hormone; Metabolism; Orexin; Sleep