title: Quantitative analysis of hypertrophic myocardium using diffusion tensor magnetic resonance imaging.
abstract: Systemic hypertension is a causative factor in left ventricular hypertrophy (LVH). This study is motivated by the potential to reverse or manage the dysfunction associated with structural remodeling of the myocardium in this pathology. Using diffusion tensor magnetic resonance imaging, we present an analysis of myocardial fiber and laminar sheet orientation inex vivohypertrophic (6 SHR) and normal (5 WKY) rat hearts using the covariance of the diffusion tensor. First, an atlas of normal cardiac microstructure was formed using the WKY b0 images. Then, the SHR and WKY b0 hearts were registered to the atlas. The acquired deformation fields were applied to the SHR and WKY heart tensor fields followed by the preservation of principal direction (PPD) reorientation strategy. A mean tensor field was then formed from the registered WKY tensor images. Calculating the covariance of the registered tensor images about this mean for each heart, the hypertrophic myocardium exhibited significantly increased myocardial fiber derangement ([Formula: see text]) with a mean dispersion of 38.7 deg, and an increased dispersion of the laminar sheet normal ([Formula: see text]) of 54.8 deg compared with 34.8 deg and 51.8 deg, respectively, in the normal hearts. Results demonstrate significantly altered myocardial fiber and laminar sheet structure in rats with hypertensive LVH.
authors.affiliation: University of California , Department of Radiology and Biomedical Imaging, Physics Research Laboratory, 185 Berry Street, Ste 350, San Francisco, United States.
authors.forename: Nicholas
authors.initials: N
authors.lastname: Tran
authors.affiliation: Royal Brompton Hospital, Cardiovascular Biomedical Research Unit, Sydney Street, London SW3 6NP, United Kingdom; National Heart and Lung Institute, Imperial College London, Sydney Street, London SW3 6NP, United Kingdom; Lawrence Berkeley National Laboratory, Structural Biology and Imaging Department, One Cyclotron Road, Berkeley, California, United States.
authors.forename: Archontis
authors.initials: A
authors.lastname: Giannakidis
authors.affiliation: University of California, Department of Radiology and Biomedical Imaging, Physics Research Laboratory, 185 Berry Street, Ste 350, San Francisco, United States; Lawrence Berkeley National Laboratory, Structural Biology and Imaging Department, One Cyclotron Road, Berkeley, California, United States; University of California, Joint Graduate Group in Bioengineering, 1700 4th Street, San Francisco, United States.
authors.forename: Grant T
authors.initials: GT
authors.lastname: Gullberg
authors.affiliation: University of California, Department of Radiology and Biomedical Imaging, Physics Research Laboratory, 185 Berry Street, Ste 350, San Francisco, United States; Lawrence Berkeley National Laboratory, Structural Biology and Imaging Department, One Cyclotron Road, Berkeley, California, United States; University of California, Joint Graduate Group in Bioengineering, 1700 4th Street, San Francisco, United States; University of California, Department of Radiation Oncology, 1600 Divisadero Street, San Francisco, United States.
authors.forename: Youngho
authors.initials: Y
authors.lastname: Seo
keywords: atlas; diffusion tensor magnetic resonance imaging; left ventricular hypertrophy; spontaneous hypertensive rat