title: Chronic high-dose glucocorticoid therapy triggers the development of chronic organ damage and worsens disease outcome in systemic lupus erythematosus.
abstract: Long-term survival of patients with systemic lupus erythematosus (SLE) improved worldwide; thus, prevention of cumulative organ damage became a major goal in disease management. The aim of our study was to investigate the chronic organ damages and their influence on disease outcome in SLE. We evaluated clinical conditions, laboratory findings and medications of 357 consecutive SLE patients and assessed their impact on Systemic Lupus Collaborating Clinics (SLICC)/American College of Rheumatology (ACR) Damage Index (SDI) and disease outcome. We detected one or more SDI scores in 77.87% of patients. Patients with disease duration of more than 10 years and subjects diagnosed at age above 40 had significantly higher SDI values. The most frequent damages were valvulopathies, cognitive dysfunction, angina pectoris and venous thrombosis. Higher cumulative glucocorticoid dose increased SDI, while chloroquin treatment was favourable for patients. Male gender, elevated SDI scores and higher cumulative doses of glucocorticoids increased mortality risk. Our data confirmed that disease duration, age at diagnosis and chronic high-dose glucocorticoid therapy have significant effects on the development of chronic organ damage. Higher SDI score is characterized with worse survival ratios. The most common chronic organ damages affected the cardiovascular or neuropsychiatric system. As long-term survival in SLE improves, it becomes increasingly important to identify the determinants of chronic organ damage. Most of the chronic organ damage occurs in the cardiovascular and the neuropsychiatric systems; thus, regular follow-up, screening and adequate therapy are essential for the best clinical outcome.
authors.affiliation: Division of Clinical Immunology, Faculty of Medicine, University of Debrecen, Móricz Zs. str. 22, Debrecen, 4032, Hungary.
authors.forename: Tünde
authors.initials: T
authors.lastname: Tarr
authors.affiliation: Division of Clinical Immunology, Faculty of Medicine, University of Debrecen, Móricz Zs. str. 22, Debrecen, 4032, Hungary.
authors.forename: Gábor
authors.initials: G
authors.lastname: Papp
authors.affiliation: Division of Clinical Immunology, Faculty of Medicine, University of Debrecen, Móricz Zs. str. 22, Debrecen, 4032, Hungary.
authors.forename: Nikolett
authors.initials: N
authors.lastname: Nagy
authors.affiliation: Division of Clinical Immunology, Faculty of Medicine, University of Debrecen, Móricz Zs. str. 22, Debrecen, 4032, Hungary.
authors.forename: Edina
authors.initials: E
authors.lastname: Cserép
authors.affiliation: Division of Clinical Immunology, Faculty of Medicine, University of Debrecen, Móricz Zs. str. 22, Debrecen, 4032, Hungary. zeher@iiibel.dote.hu.
authors.forename: Margit
authors.initials: M
authors.lastname: Zeher
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002318:Cardiovascular Diseases / Q000139:chemically induced* / Q000150:complications; D003430:Cross-Sectional Studies; D005260:Female; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000009:adverse effects* / Q000627:therapeutic use*; D006801:Humans; D053208:Kaplan-Meier Estimate; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000188:drug therapy* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D009422:Nervous System Diseases / Q000139:chemically induced* / Q000150:complications; D012219:Rheumatology / Q000379:methods; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D005938:Glucocorticoids
keywords: Chronic organ damage; Disease outcome; SLICC/ACR Damage Index; Systemic lupus erythematosus