title: Altered intrinsic brain activity after chemotherapy in patients with gastric cancer: A preliminary study.
abstract: OBJECTIVE
  To characterize the pattern of altered intrinsic brain activity in gastric cancer patients after chemotherapy (CTx).
  
  
  METHODS
  Patients before and after CTx (n = 14) and control subjects (n = 11) underwent resting-state functional MRI (rsfMRI) at baseline and 3 months after CTx. Regional homogeneity (ReHo), amplitude of low-frequency fluctuation (ALFF), and fractional ALFF (fALFF) were calculated and compared between the groups using the two-sample t test. Correlation analysis was also performed between rsfMRI values (i.e., ReHo, ALFF, and fALFF) and neuropsychological test results.
  
  
  RESULTS
  Patients showed poor performance in verbal memory and executive function and decreased rsfMRI values in the frontal areas even before CTx and showed decreased attention/working memory and executive function after CTx compared to the control subjects. In direct comparison of values before and after CTx, there were no significant differences in neuropsychological test scores, but decreased rsfMRI values were observed at the frontal lobes and right cerebellar region. Among rsfMRI values, lower ALFF in the left inferior frontal gyrus was significantly associated with poor performance of the executive function test.
  
  
  CONCLUSIONS
  We observed decreased attention/working memory and executive function that corresponded to the decline of frontal region activation in gastric cancer patients who underwent CTx.
  
  
  CONCLUSIONS
  • Intrinsic brain activity of gastric cancer patients after chemotherapy was described. • Brain activity and neuropsychological test results were correlated. • Working memory and executive function decreased after chemotherapy. • Decreased cognitive function corresponded to decreased activation of the frontal region.
authors.affiliation: Department of Radiology, Ajou University School of Medicine, Ajou University Medical Center, Suwon, Korea.
authors.forename: Hyun Gi
authors.initials: HG
authors.lastname: Kim
authors.affiliation: Department of Radiology, Ewha Womans University School of Medicine, 911-1 Mokdong, Yangcheon-gu, Seoul, 158-710, Korea. nyshin@ewha.ac.kr.|Department of Radiology, Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul, Korea. nyshin@ewha.ac.kr.
authors.forename: Na-Young
authors.initials: NY
authors.lastname: Shin
authors.affiliation: Department of Radiology, Ewha Womans University School of Medicine, 911-1 Mokdong, Yangcheon-gu, Seoul, 158-710, Korea.
authors.forename: Yunjin
authors.initials: Y
authors.lastname: Bak
authors.affiliation: Department of Psychiatry, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Kyung Ran
authors.initials: KR
authors.lastname: Kim
authors.affiliation: Department of Psychiatry, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Young-Chul
authors.initials: YC
authors.lastname: Jung
authors.affiliation: Department of Radiology, Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Kyunghwa
authors.initials: K
authors.lastname: Han
authors.affiliation: Department of Radiology, Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Seung-Koo
authors.initials: SK
authors.lastname: Lee
authors.affiliation: Department of Radiology, Ewha Womans University School of Medicine, 911-1 Mokdong, Yangcheon-gu, Seoul, 158-710, Korea.
authors.forename: Soo Mee
authors.initials: SM
authors.lastname: Lim
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D000970:Antineoplastic Agents / Q000009:adverse effects*; D001288:Attention / Q000187:drug effects / Q000502:physiology; D001921:Brain / Q000187:drug effects / Q000503:physiopathology*; D016022:Case-Control Studies; D003071:Cognition / Q000187:drug effects / Q000502:physiology; D056344:Executive Function / Q000187:drug effects / Q000502:physiology; D005625:Frontal Lobe / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011446:Prospective Studies; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000503:physiopathology; D014706:Verbal Learning / Q000187:drug effects / Q000502:physiology
chemical_list: D000970:Antineoplastic Agents
keywords: Brain; Cancer chemotherapy agents; Cognitive function; Functional magnetic resonance imaging; Gastric cancer