title: The Application of Multiplex Biomarker Techniques for Improved Stratification and Treatment of Schizophrenia Patients.
abstract: In the case of major psychiatric disorders such as schizophrenia, shortcomings in the conversion of scientific discoveries into newer and safer treatment options has led to a loss of confidence and precipitated a crisis for large pharmaceutical companies. This chapter describes how incorporation of multiplex biomarker approaches into the clinical pipeline can lead to better patient characterization, delivery of novel treatment approaches and help to renew efforts in this important area. The development of specific biomarker test panels for disease prediction should facilitate early intervention strategies, which may help to slow disease development or progression. Furthermore, the development of such tests using lab-on-a-chip and smartphone platforms will help to shift diagnosis and treatment of this major disorder into a point-of-care setting for improved patient outcomes.
authors.affiliation: Department of Psychiatry, University of Magdeburg, Leipziger Strasse 44, 39120, Magdeburg, Germany. johann.steiner@med.ovgu.de.
authors.forename: Johann
authors.initials: J
authors.lastname: Steiner
authors.affiliation: Laboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Rua Monteiro Lobato 255, Cidade Universitária Zeferino Vaz, 13083-862, Campinas, Brazil.
authors.forename: Paul C
authors.initials: PC
authors.lastname: Guest
authors.affiliation: Department of Chemical Engineering and Biotechnology, University of Cambridge, Pembroke Street, Cambridge, UK.
authors.forename: Hassan
authors.initials: H
authors.lastname: Rahmoune
authors.affiliation: Laboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Rua Monteiro Lobato 255, Cidade Universitária Zeferino Vaz, 13083-862, Campinas, SP, Brazil.
authors.forename: Daniel
authors.initials: D
authors.lastname: Martins-de-Souza
mesh_terms: D015415:Biomarkers; D055808:Drug Discovery / Q000379:methods; D023281:Genomics / Q000379:methods / Q000592:standards; D006801:Humans; D025202:Molecular Diagnostic Techniques; D019095:Point-of-Care Systems; D011379:Prognosis; D040901:Proteomics / Q000379:methods / Q000592:standards; D012559:Schizophrenia / Q000175:diagnosis* / Q000209:etiology / Q000378:metabolism / Q000628:therapy*; D017216:Telemedicine / Q000379:methods
chemical_list: D015415:Biomarkers
keywords: Blood-based biomarkers; Lab-on-a-chip; Mass spectrometry; Multiplex immunoassay; Point-of-care; Proteomics; Schizophrenia; Smartphone apps