title: Perioperative Antihypertensive Treatment in Patients With Spontaneous Intracerebral Hemorrhage.
abstract: Studies on antihypertensive treatment for surgical patients with spontaneous intracerebral hemorrhage are insufficient. This pilot study was conducted to investigate the safety of the perioperative intensive blood pressure lowering in surgical patients with spontaneous intracerebral hemorrhage.
  
  
  
  This study was a prospective, parallel, randomized, assessor-blinded trial. Patients allocated to the intensive group received perioperative intensive antihypertensive treatment aiming to achieve a target systolic blood pressure between 120 and 140 mm Hg, whereas the patients in the conservative group received conservative treatment aiming to achieve a target systolic blood pressure between 140 and 180 mm Hg for 7 days. The primary outcome was the rate of rehemorrhage at 7 days after surgery.
  
  
  
  Rehemorrhage was noted in 11 patients (11%) in the intensive group and 14 (14%) in the conservative group (P=0.689). There was no significant difference in mortality at 7 days (4.0% versus 10.0%; P=0.164), 30 days (10.4% versus 17.2%; P=0.247), and 90 days (13.5% versus 18.2%; P=0.490) between the 2 groups.
  
  
  
  Perioperative intensive blood pressure lowering was not associated with a reduced incidence of rehemorrhage, death, or other serious adverse events.
  
  
  
  URL: http://www.chictr.org.cn/. Unique identifier: ChiCTR-TRC-13004304.
authors.affiliation: From the Department of Neurosurgery (J.Z., H.L., S.L., J.M., R.G., L.M., Y.F., M.T., C.Y.) and Department of Neurology (M.L.), West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Zheng
authors.affiliation: From the Department of Neurosurgery (J.Z., H.L., S.L., J.M., R.G., L.M., Y.F., M.T., C.Y.) and Department of Neurology (M.L.), West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Li
authors.affiliation: From the Department of Neurosurgery (J.Z., H.L., S.L., J.M., R.G., L.M., Y.F., M.T., C.Y.) and Department of Neurology (M.L.), West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Sen
authors.initials: S
authors.lastname: Lin
authors.affiliation: From the Department of Neurosurgery (J.Z., H.L., S.L., J.M., R.G., L.M., Y.F., M.T., C.Y.) and Department of Neurology (M.L.), West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Junpeng
authors.initials: J
authors.lastname: Ma
authors.affiliation: From the Department of Neurosurgery (J.Z., H.L., S.L., J.M., R.G., L.M., Y.F., M.T., C.Y.) and Department of Neurology (M.L.), West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Guo
authors.affiliation: From the Department of Neurosurgery (J.Z., H.L., S.L., J.M., R.G., L.M., Y.F., M.T., C.Y.) and Department of Neurology (M.L.), West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Ma
authors.affiliation: From the Department of Neurosurgery (J.Z., H.L., S.L., J.M., R.G., L.M., Y.F., M.T., C.Y.) and Department of Neurology (M.L.), West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Fang
authors.affiliation: From the Department of Neurosurgery (J.Z., H.L., S.L., J.M., R.G., L.M., Y.F., M.T., C.Y.) and Department of Neurology (M.L.), West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Meng
authors.initials: M
authors.lastname: Tian
authors.affiliation: From the Department of Neurosurgery (J.Z., H.L., S.L., J.M., R.G., L.M., Y.F., M.T., C.Y.) and Department of Neurology (M.L.), West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Liu
authors.affiliation: From the Department of Neurosurgery (J.Z., H.L., S.L., J.M., R.G., L.M., Y.F., M.T., C.Y.) and Department of Neurology (M.L.), West China Hospital, Sichuan University, Chengdu, China. ns_youchao@126.com.
authors.forename: Chao
authors.initials: C
authors.lastname: You
mesh_terms: D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000008:administration & dosage*; D002543:Cerebral Hemorrhage / Q000175:diagnosis / Q000188:drug therapy* / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019990:Perioperative Care / Q000379:methods*; D010865:Pilot Projects; D011446:Prospective Studies; D016037:Single-Blind Method; D016896:Treatment Outcome
chemical_list: D000959:Antihypertensive Agents
keywords: antihypertensive agents; blood pressure; cerebral hemorrhage; prospective studies; randomized controlled trial