title: Partial interhemispheric disconnection syndrome (P-IHDS) secondary to Marchiafava-Bignami disease type B (MBD-B).
abstract: A 53-year-old man with a 35-year history of excessive alcohol intake presents to our neurology department with 4-year history of progressive neurocognitive deterioration and disconnection syndrome. MRI head demonstrates extensive demyelination of the corpus callosum (and of extracallosal sites as well), leading to a diagnosis of Marchiafava-Bignami disease. He was given treatment with vitamin B complex (including folate) and was assessed and managed by psychology, occupational therapy and physiotherapy with initial signs of improvement.
authors.affiliation: Department of Stroke and Neurology, James Paget University Hospital, Great Yarmouth, Norfolk, UK.
authors.forename: Carlo
authors.initials: C
authors.lastname: Canepa
authors.affiliation: James Paget University Hospitals NHS Foundation Trust, Great Yarmouth, Norfolk, UK.
authors.forename: Lorena
authors.initials: L
authors.lastname: Arias
mesh_terms: D000437:Alcoholism / Q000150:complications* / Q000175:diagnosis / Q000473:pathology / Q000628:therapy; D001921:Brain / Q000473:pathology; D003072:Cognition Disorders / Q000150:complications* / Q000175:diagnosis* / Q000628:therapy; D003337:Corpus Callosum / Q000000981:diagnostic imaging / Q000473:pathology*; D003937:Diagnosis, Differential; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D054319:Marchiafava-Bignami Disease / Q000150:complications* / Q000175:diagnosis* / Q000628:therapy; D008875:Middle Aged; D009788:Occupational Therapy; D026741:Physical Therapy Modalities; D013577:Syndrome; D014803:Vitamin B Complex / Q000627:therapeutic use
chemical_list: D014803:Vitamin B Complex