title: Central Nervous System Symptoms Due to Transient Methemoglobinemia in a Child With G6PD Deficiency.
abstract: The authors herein report a 5-year-old child who presented with massive hemolysis, irritability, and cyanosis. The final diagnosis was glucose-6-phosphate dehydrogenase deficiency with associated central nervous system symptoms probably because of concomitantly acquired methemoglobinemia following oxidant drug exposure. The associated acute-onset anemia would have contributed to the development of cerebral anoxia-related seizures and encephalopathy.
authors.affiliation: Department of Pediatrics, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, India.
authors.forename: Shreya
authors.initials: S
authors.lastname: Sharma
authors.forename: Rangan
authors.initials: R
authors.lastname: Srinivasaraghavan
authors.forename: Sriram
authors.initials: S
authors.lastname: Krishnamurthy
mesh_terms: D000208:Acute Disease; D002675:Child, Preschool; D003241:Consanguinity; D003490:Cyanosis / Q000209:etiology; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000150:complications* / Q000175:diagnosis / Q000235:genetics; D006801:Humans; D007508:Irritable Mood; D008297:Male; D008708:Methemoglobinemia / Q000139:chemically induced / Q000209:etiology* / Q000523:psychology / Q000652:urine; D009643:Norfloxacin / Q000009:adverse effects* / Q000627:therapeutic use; D016877:Oxidants / Q000009:adverse effects* / Q000627:therapeutic use; D012008:Recurrence; D012640:Seizures / Q000209:etiology*
chemical_list: D016877:Oxidants; D009643:Norfloxacin