title: Antioxidant and Antimutagenic Metabolites in Animals with Opposite Sensitivity to Tuberculosis Mycobacteria and Mutagenic Xenobiotics.
abstract: Different sensitivity of guinea pigs and rats to Mycobacterium tuberculosis and membranotropic mutagenic xenobiotics is associated with differences in the metabolism of amino acid precursors of phospholipids. In turn, specific features of phospholipid metabolism are determined by differences in the level of sulfur-containing regulatory metabolites (methionine, taurine, and glutathione) in tissues. Taurine and methionine increase organism's resistance to Mycobacterium tuberculosis (typical of rats), glutathione and its constituent amino acids improve resistance to the mutagenic effects of xenobiotics (typical of guinea pigs). These metabolites can be used for strengthening of natural resistance to tuberculosis and mutagenic and carcinogenic xenobiotics.
authors.affiliation: Ural Research Institute of Phthisiopulmonology, Ministry of Health of Russian Federation, Moscow, Russia.
authors.forename: V A
authors.initials: VA
authors.lastname: Pavlov
authors.affiliation: Ural Research Institute of Phthisiopulmonology, Ministry of Health of Russian Federation, Moscow, Russia. 2134012@gmail.com.|Institute of Immunology and Physiology, Ural Division of the Russian Academy of Sciences, Ekaterinburg, Russia. 2134012@gmail.com.
authors.forename: V V
authors.initials: VV
authors.lastname: Kotomtsev
authors.affiliation: Ural Research Institute of Phthisiopulmonology, Ministry of Health of Russian Federation, Moscow, Russia.
authors.forename: A I
authors.initials: AI
authors.lastname: Doronin
authors.affiliation: Ural Research Institute of Phthisiopulmonology, Ministry of Health of Russian Federation, Moscow, Russia.
authors.forename: E V
authors.initials: EV
authors.lastname: Sabadash
mesh_terms: D000818:Animals; D004198:Disease Susceptibility / Q000276:immunology; D019856:Ethanolamine / Q000378:metabolism*; D004983:Ethanolamines / Q000378:metabolism*; D005978:Glutathione / Q000378:metabolism; D006168:Guinea Pigs; D008099:Liver / Q000378:metabolism / Q000382:microbiology; D008715:Methionine / Q000378:metabolism; D009153:Mutagens / Q000633:toxicity; D009169:Mycobacterium tuberculosis / Q000254:growth & development / Q000472:pathogenicity; D009369:Neoplasms / Q000139:chemically induced / Q000276:immunology / Q000378:metabolism*; D051381:Rats; D012694:Serine / Q000378:metabolism*; D013045:Species Specificity; D013654:Taurine / Q000378:metabolism*; D014376:Tuberculosis / Q000276:immunology / Q000378:metabolism* / Q000382:microbiology; D015262:Xenobiotics / Q000633:toxicity
chemical_list: D004983:Ethanolamines; D009153:Mutagens; D015262:Xenobiotics; D013654:Taurine; D012694:Serine; D019856:Ethanolamine; C005448:phosphorylethanolamine; D008715:Methionine; D005978:Glutathione
keywords: amino acids; membrane phospholipids; mutagens and carcinogens; nitrogen compounds; tuberculosis