title: Regenerative Medicine: lessons from Mother Nature.
abstract: Regenerative medicine strategies for the restoration of functional tissue have evolved from the concept of ex vivo creation of engineered tissue toward the broader concept of in vivo induction of functional tissue reconstruction. Multidisciplinary approaches are being investigated to achieve this goal using evolutionarily conserved principles of stem cell biology, developmental biology and immunology, current methods of engineering and medicine. This evolution from ex vivo tissue engineering to the manipulation of fundamental in vivo tenets of development and regeneration has the potential to capitalize upon the incredibly complex and only partially understood ability of cells to adapt, proliferate, self-organize and differentiate into functional tissue.
authors.affiliation: McGowan Institute for Regenerative Medicine, Pittsburgh, PA 15219, USA.|Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA.
authors.forename: Juan Diego
authors.initials: JD
authors.lastname: Naranjo
authors.affiliation: McGowan Institute for Regenerative Medicine, Pittsburgh, PA 15219, USA.|Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA.
authors.forename: Michelle E
authors.initials: ME
authors.lastname: Scarritt
authors.affiliation: McGowan Institute for Regenerative Medicine, Pittsburgh, PA 15219, USA.|Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA.
authors.forename: Luai
authors.initials: L
authors.lastname: Huleihel
authors.affiliation: McGowan Institute for Regenerative Medicine, Pittsburgh, PA 15219, USA.|Division of Pediatric Pulmonary Medicine, Allergy & Immunology, Children's Hospital of UPMC, Pittsburgh, PA 15224, USA.
authors.forename: Anjani
authors.initials: A
authors.lastname: Ravindra
authors.affiliation: McGowan Institute for Regenerative Medicine, Pittsburgh, PA 15219, USA.|Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA.
authors.forename: Crisanto M
authors.initials: CM
authors.lastname: Torres
authors.affiliation: McGowan Institute for Regenerative Medicine, Pittsburgh, PA 15219, USA.|Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA.|Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15213, USA.
authors.forename: Stephen F
authors.initials: SF
authors.lastname: Badylak
mesh_terms: D000818:Animals; D015509:Developmental Biology; D006801:Humans; D044968:Regenerative Medicine; D023822:Tissue Engineering / Q000379:methods*
keywords: bioscaffolds; blastema; constructive remodeling; development; microenvironmental niche; regeneration; stem cell; tissue engineering; whole-organ engineering