title: Two Cases of Chromomycosis Identified by Molecular Phylogenetic Analysis.
abstract: Chromomycosis is an infection caused by dematiaceous fungi. These fungi belong to several genera with varied clinical presentations and parasitic forms. The disease is roughly classified into three types: chromoblastomycosis, black-grain mycetoma, and phaeohyphomycosis. While there are many kinds of dematiaceous fungi, the major etiologic agent is Fonsecaea pedrosoi, which to date has accounted for 90% of chromoblastomycosis cases. The genus Fonsecaea has recently been assessed via rRNA ITS sequence analysis, and species have been classified into F. pedrosoi, F. monophora, and others. We encountered two cases of chromomycosis that had developed on facial and upper arm areas. Neither of the etiologic agents could be identified through morphological examination under a microscope; however, F. monophora was confirmed using molecular phylogenetic analysis. Indeed, molecular phylogenetic analysis has revealed that the etiologic agents in many reported cases of F. pedrosoi infections were actually F. monophora. This suggests that it is now necessary to reconsider the classification of genus Fonsecaea.
authors.affiliation: Department of Dermatology, Kyorin University School of Medicine.
authors.forename: Takayo
authors.initials: T
authors.lastname: Mitomo
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Ushigome
authors.forename: Tomoo
authors.initials: T
authors.lastname: Fukuda
authors.forename: Yoko
authors.initials: Y
authors.lastname: Kano
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Shiohara
mesh_terms: D000368:Aged; D001203:Ascomycota / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification* / Q000472:pathogenicity; D002862:Chromoblastomycosis / Q000145:classification / Q000175:diagnosis* / Q000382:microbiology* / Q000628:therapy; D003937:Diagnosis, Differential; D005145:Face; D005260:Female; D005542:Forearm; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D010802:Phylogeny; D016896:Treatment Outcome