title: Serum uric acid and impaired cognitive function in community-dwelling elderly in Beijing.
abstract: The relationship between serum uric acid (sUA) and cognitive function is contradictory. This study assessed the association between sUA and cognitive impairment in 10,039 community-dwelling subjects aged ≥55years living in Beijing, China. Participants underwent determination of sUA and an evaluation of cognitive function using the scholarship-adjusted Mini-Mental State Examination (MMSE): MMSE ≤17 for illiterates; MMSE≤20 for primary school graduates (≥6years of education); and MMSE≤24 for junior school graduates or above (≥9years of education). Among the 10016 persons with valid MMSE scores, the prevalence of cognitive impairment was 9.14%. A multivariate logistic regression model including demographic, clinical and genetic parameters was performed to assess the relationship between sUA and cognitive impairment. Persons with cognitive impairment had lower sUA levels than those with normal cognitive function: (302.30±82.80 vs. 312.20±84.01μmol/L, p=0.001). After adjusting for age, sex, lifestyle, relevant diseases and the apolipoprotein E (APOE) ε4 allele, stepwise logistic regression showed that participants with higher levels of sUA had a lower risk of cognitive impairment (hazard ratio (HR): 0.78; 95% confidence interval (CI): 0.62-0.96; p=0.022). In this baseline cross-sectional population-based sample, high levels of sUA were associated with a decreased risk of cognitive impairment.
authors.affiliation: Department of Endocrinology, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing, 100053, China; Department of Geriatrics, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing, 100053, China.
authors.forename: Shuangling
authors.initials: S
authors.lastname: Xiu
authors.affiliation: Department of Neurobiology, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing, 100053, China; Department of Geriatrics, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing, 100053, China; Parkinson's Disease Center of Beijing Institute for Brain Disorders, Beijing 100053, China; Key Laboratory on Neurodegenerative Disease of Ministry of Education, Beijing 100053, China; Beijing Key Laboratory for Parkinson's Disease, Beijing 100053, China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Zheng
authors.affiliation: Evidence-Based Medicine Center, Xuanwu Hospital of Capital Medical University, Beijing 100053, China.
authors.forename: Shaochen
authors.initials: S
authors.lastname: Guan
authors.affiliation: Department of Neurobiology, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing, 100053, China; Department of Geriatrics, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing, 100053, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Neurology, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing, 100053, China.
authors.forename: Jinghong
authors.initials: J
authors.lastname: Ma
authors.affiliation: Department of Neurobiology, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing, 100053, China; Department of Geriatrics, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing, 100053, China; Department of Neurology, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing, 100053, China; Parkinson's Disease Center of Beijing Institute for Brain Disorders, Beijing 100053, China; Key Laboratory on Neurodegenerative Disease of Ministry of Education, Beijing 100053, China; Beijing Key Laboratory for Parkinson's Disease, Beijing 100053, China. Electronic address: pbchan90@gmail.com.
authors.forename: Piu
authors.initials: P
authors.lastname: Chan
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D000068476:Beijing; D003071:Cognition / Q000502:physiology*; D003072:Cognition Disorders / Q000175:diagnosis / Q000503:physiopathology*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D057187:Independent Living; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D018570:Risk Assessment / Q000379:methods; D014527:Uric Acid / Q000097:blood*
chemical_list: D014527:Uric Acid
keywords: Cognitive impairment; MMSE; Risk factors; Serum uric acid (sUA)