title: Effect of Calcitriol Supplementation on Blood Pressure in Older Adults.
abstract: Recent studies suggest that vitamin D plays an important role in the control of blood pressure. Unfortunately, because older adults are more likely to have low 25-hydroxyvitamin-D [25(OH)D] levels, this study investigated whether calcitriol supplementation reduces blood pressure in older adults with hypertension. The design was a double-blind placebo-controlled randomized clinical trial with 36 randomly assigned subjects (71.7 ± 10 years). Blood pressure and serum levels of 25(OH)D before and after calcitriol intervention (1,000 IU daily for 6 weeks; n = 22) or placebo (n = 23) for 6 weeks were analyzed. At the end of the study, the calcitriol group presented a significant decrease of systolic blood pressure [20.25 mmHg (p = 0.001)] and diastolic blood pressure [7 mmHg (p = 0.01)], compared with the placebo group. In conclusion, 1,000 IU/day of calcitriol for 6 weeks efficiently reduced systolic and diastolic blood pressure levels in this population of older adults presenting with high blood pressure (Clinical Trial Approbation NCT02047799).
authors.affiliation: a Facultad de Medicina , Universidad de Colima , Colima , Mexico.
authors.forename: Jaime Alberto
authors.initials: JA
authors.lastname: Bricio-Barrios
authors.affiliation: a Facultad de Medicina , Universidad de Colima , Colima , Mexico.
authors.forename: Alín Jael
authors.initials: AJ
authors.lastname: Palacios-Fonseca
authors.affiliation: a Facultad de Medicina , Universidad de Colima , Colima , Mexico.
authors.forename: Mario
authors.initials: M
authors.lastname: Del Toro-Equihua
authors.affiliation: a Facultad de Medicina , Universidad de Colima , Colima , Mexico.
authors.forename: Carmen Alicia
authors.initials: CA
authors.lastname: Sanchez-Ramirez
mesh_terms: D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D002117:Calcitriol / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology / Q000627:therapeutic use*; D019587:Dietary Supplements; D004311:Double-Blind Method; D005260:Female; D006299:Health Services for the Aged; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D016896:Treatment Outcome
chemical_list: D002117:Calcitriol
keywords: Blood pressure; calcitriol; hypertension; older adults; vitamin D