title: Diagnostic ability of peripapillary vessel density measurements of optical coherence tomography angiography in primary open-angle and angle-closure glaucoma.
abstract: To evaluate the diagnostic ability of peripapillary vessel density measurements on optical coherence tomography angiography (OCTA) in primary open-angle glaucoma (POAG) and primary angle-closure glaucoma (PACG), and to compare these with peripapillary retinal nerve fibre layer (RNFL) thickness measurements.
  
  
  
  In a cross-sectional study, 48 eyes of 33 healthy control subjects, 63 eyes of 39 patients with POAG and 49 eyes of 32 patients with PACG underwent OCTA (RTVue-XR, Optovue, Fremont, California, USA) and RNFL imaging with spectral domain OCT. Diagnostic abilities of vessel density and RNFL parameters were evaluated using area under receiver operating characteristic curves (AUC) and sensitivities at fixed specificities.
  
  
  
  AUCs of peripapillary vessel density ranged between 0.48 for the temporal sector and 0.88 for the inferotemporal sector in POAG. The same in PACG ranged between 0.57 and 0.86. Sensitivities at 95% specificity ranged from 13% to 70% in POAG, and from 10% to 67% in PACG. AUCs of peripapillary RNFL thickness ranged between 0.51 for the temporal sector and 0.91 for the inferonasal sector in POAG. The same in PACG ranged between 0.61 and 0.87. Sensitivities at 95% specificity ranged from 8% to 68% in POAG, and from 2% to 67% in PACG. AUCs of all peripapillary vessel density measurements were comparable (p>0.05) to the corresponding RNFL thickness measurements in both POAG and PACG.
  
  
  
  Diagnostic ability of peripapillary vessel density parameters of OCTA, especially the inferotemporal sector measurement, was good in POAG and PACG. Diagnostic abilities of vessel density measurements were comparable to RNFL measurements in both POAG and PACG.
authors.affiliation: Narayana Nethralaya, Rajajinagar, Bangalore, India.
authors.forename: Harsha L
authors.identifier: 0000-0001-5866-9856
authors.initials: HL
authors.lastname: Rao
authors.affiliation: Narayana Nethralaya, Rajajinagar, Bangalore, India.
authors.forename: Sujatha V
authors.initials: SV
authors.lastname: Kadambi
authors.affiliation: Shiley Eye Institute, Hamilton Glaucoma Center and Department of Ophthalmology, University of California, San Diego, 9500 Gilman Drive, La Jolla, California, USA.
authors.forename: Robert N
authors.initials: RN
authors.lastname: Weinreb
authors.affiliation: Narayana Nethralaya, Rajajinagar, Bangalore, India.
authors.forename: Narendra K
authors.initials: NK
authors.lastname: Puttaiah
authors.affiliation: Narayana Nethralaya, Rajajinagar, Bangalore, India.
authors.forename: Zia S
authors.initials: ZS
authors.lastname: Pradhan
authors.affiliation: Narayana Nethralaya, Rajajinagar, Bangalore, India.
authors.forename: Dhanaraj A S
authors.initials: DAS
authors.lastname: Rao
authors.affiliation: Narayana Nethralaya, Rajajinagar, Bangalore, India.
authors.forename: Rajesh S
authors.initials: RS
authors.lastname: Kumar
authors.affiliation: University Eye Clinic Maastricht, University Medical Center, Maastricht, The Netherlands.
authors.forename: Carroll A B
authors.initials: CAB
authors.lastname: Webers
authors.affiliation: Narayana Nethralaya, Rajajinagar, Bangalore, India.
authors.forename: Rohit
authors.initials: R
authors.lastname: Shetty
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D000072226:Computed Tomography Angiography / Q000379:methods; D003430:Cross-Sectional Studies; D005260:Female; D015812:Glaucoma, Angle-Closure / Q000000981:diagnostic imaging*; D005902:Glaucoma, Open-Angle / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers; D012372:ROC Curve; D012171:Retinal Vessels / Q000000981:diagnostic imaging; D041623:Tomography, Optical Coherence / Q000379:methods
keywords: Glaucoma; Imaging