title: Mesenchymal stem cells: a promising tool for targeted gene therapy of endometriosis.
abstract: Endometriosis is a leading, benign gynecological disorder around the world. Last few years have witnessed tremendous growth in the field of endometriosis and endometrial stem-cell research. Despite advancements in the biology and pathology of endometriosis, disease recurrence is still an enigma. Gene therapy holds promise in treating many pathologic conditions including endometriosis. Mesenchymal stem cells (MSCs) serve as ideal candidates for regenerative medicine and cell-based therapies. Owing to their specificity to the endometrium, residing endometrial MSC populations could be utilized as ideal candidates for targeting endometrial disorders. Recently, we demonstrated their flexibility for gene transduction using adenoviral vectors. The review highlights the potential of endometrial MSCs in devising targeted gene therapies for endometriosis.
authors.affiliation: Department of Innate Immunity, National Institute for Research in Reproductive Health (ICMR), Parel, Mumbai, India.
authors.forename: Aghila Rani
authors.initials: AR
authors.lastname: Koippallil Gopalakrishnan
authors.affiliation: Biosciences, College of Health & Life Science, Brunel University London, Uxbridge, UB83PH, UK.
authors.forename: Uday
authors.initials: U
authors.lastname: Kishore
authors.affiliation: Department of Innate Immunity, National Institute for Research in Reproductive Health (ICMR), Parel, Mumbai, India.
authors.forename: Taruna
authors.initials: T
authors.lastname: Madan
mesh_terms: D004715:Endometriosis / Q000628:therapy*; D005260:Female; D015316:Genetic Therapy; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D044968:Regenerative Medicine
keywords: angiogenesis; endometrial stem cells; endometriosis; gene therapy; mesenchymal stem cells