title: Molecular profiles in foregut oncology.
abstract: Oncology is and will continue to evolve resulting from a better understanding of the biology and intrinsic genetic profile of each cancer. Tumor biomarkers and targeted therapies are the new face of precision medicine, so it is essential for all physicians caring for cancer patients to understand and assist patients in understanding the role and importance of such markers and strategies to target them. This review was initiated in an attempt to identify, characterize, and discuss literature supporting clinically relevant molecular markers and interventions. The efficacy of targeting specific markers will be examined with data from clinical trials focusing on treatments for esophageal, gastric, liver, gallbladder, biliary tract, and pancreatic cancers.
authors.affiliation: Florida Hospital Tampa, 3000 Medical Park Drive Suite 310, Tampa, FL 33613, USA.
authors.forename: Prashant
authors.initials: P
authors.lastname: Sukharamwala
authors.affiliation: Florida Hospital Tampa, 3000 Medical Park Drive Suite 310, Tampa, FL 33613, USA.
authors.forename: Daniel
authors.initials: D
authors.lastname: Hennessey
authors.affiliation: Florida Hospital Tampa, 3000 Medical Park Drive Suite 310, Tampa, FL 33613, USA.
authors.forename: Thomas
authors.initials: T
authors.lastname: Wood
authors.affiliation: Florida Hospital Tampa, 3000 Medical Park Drive Suite 310, Tampa, FL 33613, USA.
authors.forename: Shelly
authors.initials: S
authors.lastname: Singh
authors.affiliation: Florida Hospital Tampa, 3000 Medical Park Drive Suite 310, Tampa, FL 33613, USA.
authors.forename: Carrie
authors.initials: C
authors.lastname: Ryan
authors.affiliation: Florida Hospital Tampa, 3000 Medical Park Drive Suite 310, Tampa, FL 33613, USA. Electronic address: Alexander.Rosemurgy@ahss.org.
authors.forename: Alexander
authors.initials: A
authors.lastname: Rosemurgy
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics*; D005770:Gastrointestinal Neoplasms / Q000188:drug therapy / Q000235:genetics*; D006801:Humans; D058990:Molecular Targeted Therapy; D057285:Precision Medicine; D059467:Transcriptome
chemical_list: D014408:Biomarkers, Tumor
keywords: Cancer; digestive system; liver; neoplasm; tumor marker