title: An α-helical peptidomimetic scaffold for dynamic combinatorial library formation.
abstract: A novel oligobenzamide-based α-helix mimetic was designed and synthesised with either imine or hydrazone functionalities that serve both to pre-organise the side-chain vectors to mimic the i, i + 4 and i + 7 residues of an α-helix, and to allow for the facile creation of dynamic libraries.
authors.affiliation: Department of Chemistry, New York University, 100 Washington Square East, New York, NY 10003, USA. andrew.hamilton@nyu.edu and Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK. sam.thompson@chem.ox.ac.uk.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Busschaert
authors.affiliation: Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK. sam.thompson@chem.ox.ac.uk and Chemistry, University of Southampton, Southampton, SO17 1BJ, UK. sam.thompson@soton.ac.uk.
authors.forename: Sam
authors.initials: S
authors.lastname: Thompson
authors.affiliation: Department of Chemistry, New York University, 100 Washington Square East, New York, NY 10003, USA. andrew.hamilton@nyu.edu and Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK. sam.thompson@chem.ox.ac.uk.
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Hamilton
mesh_terms: D020650:Combinatorial Chemistry Techniques; D008958:Models, Molecular; D057786:Peptidomimetics / Q000138:chemical synthesis* / Q000737:chemistry*; D000072756:Protein Conformation, alpha-Helical
chemical_list: D057786:Peptidomimetics