title: Lysine linkage in abasic site-binding ligand-thiazole orange conjugates for improved binding affinity to orphan nucleobases in DNA/RNA hybrids.
abstract: Introduction of lysine linkage in the conjugate between abasic site-binding ligands and thiazole orange significantly improved the binding affinity for target orphan adenine or uracil nucleobase in DNA/RNA hybrids.
authors.affiliation: Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 980-8578, Japan. nishi@m.tohoku.ac.jp.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Sato
authors.affiliation: Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 980-8578, Japan. nishi@m.tohoku.ac.jp.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Saito
authors.affiliation: Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 980-8578, Japan. nishi@m.tohoku.ac.jp.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Aoki
authors.affiliation: Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 980-8578, Japan. nishi@m.tohoku.ac.jp.
authors.forename: Norio
authors.initials: N
authors.lastname: Teramae
authors.affiliation: Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 980-8578, Japan. nishi@m.tohoku.ac.jp.
authors.forename: Seiichi
authors.initials: S
authors.lastname: Nishizawa
mesh_terms: D052160:Benzothiazoles / Q000737:chemistry*; D001665:Binding Sites; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D005453:Fluorescence; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry; D008024:Ligands; D008239:Lysine / Q000737:chemistry*; D015394:Molecular Structure; D011804:Quinolines / Q000737:chemistry*; D012313:RNA / Q000737:chemistry* / Q000378:metabolism
chemical_list: D052160:Benzothiazoles; D005456:Fluorescent Dyes; D008024:Ligands; D011804:Quinolines; C051000:thiazole orange; D012313:RNA; D004247:DNA; D008239:Lysine