title: Insulin-like growth factor 1 and metabolic parameters are associated with nonalcoholic fatty liver disease in obese children and adolescents.
abstract: OBJECTIVE
  Few studies have investigated the relationship between paediatric nonalcoholic fatty liver disease (NAFLD) and insulin-like growth factor 1 (IGF-1). This study, carried out from July 2013 to September 2015, aimed to fill the gap and added metabolic parameters to the analysis.
  
  
  METHODS
  This was a cross-sectional study of 168 obese children and adolescents (84% male), divided into two groups based on the presence (n = 90) or absence (n = 78) of NAFLD. All participants underwent clinical examinations, anthropometric and laboratory examinations and liver ultrasonography.
  
  
  RESULTS
  Nonalcoholic fatty liver disease patients had significantly lower IGF-1 standard deviation score (IGF-1 SDS) and higher body mass index (BMI), homeostasis model assessment of insulin resistance (HOMA-IR) and uric acid levels than the control group. The prevalence rate of NAFLD was negatively correlated with the IGF-1 SDS. IGF-1 SDS was negatively associated with NAFLD, while BMI, HOMA-IR and uric acid were positively associated with NAFLD. The combined analysis of the area under the receiver operating characteristic curve for multiple variables, including IGF-1 SDS, BMI, HOMA-IR and uric acid, was 0.812, with a sensitivity of 78.89% and specificity of 74.36%.
  
  
  CONCLUSIONS
  IGF-1, BMI, HOMA-IR and uric acid were useful markers of NAFLD in obese children and adolescents.
authors.affiliation: Department of Pediatrics, Shandong Provincial Hospital Affiliated to Shandong University, Shandong, China.
authors.forename: Shuang
authors.initials: S
authors.lastname: Liang
authors.affiliation: Department of Pediatrics, Shandong Provincial Hospital Affiliated to Shandong University, Shandong, China.
authors.forename: Xiangdeng
authors.initials: X
authors.lastname: Cheng
authors.affiliation: Department of Pediatrics, Shandong Provincial Hospital Affiliated to Shandong University, Shandong, China.
authors.forename: Yanyan
authors.initials: Y
authors.lastname: Hu
authors.affiliation: Department of Ultrasound, Shandong Provincial Hospital Affiliated to Shandong University, Shandong, China.
authors.forename: Ruxin
authors.initials: R
authors.lastname: Song
authors.affiliation: Department of Pediatrics, Shandong Provincial Hospital Affiliated to Shandong University, Shandong, China.
authors.forename: Guimei
authors.initials: G
authors.lastname: Li
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008297:Male; D015999:Multivariate Analysis; D065626:Non-alcoholic Fatty Liver Disease / Q000097:blood* / Q000209:etiology; D063766:Pediatric Obesity / Q000097:blood* / Q000150:complications; D012372:ROC Curve; D012189:Retrospective Studies; D012307:Risk Factors; D014527:Uric Acid / Q000097:blood
chemical_list: D015415:Biomarkers; C583557:IGF1 protein, human; D014527:Uric Acid; D007334:Insulin-Like Growth Factor I
keywords: Body mass index; Homeostasis model assessment of insulin resistance; Insulin-like growth factor 1; Nonalcoholic fatty liver disease; Uric acid