title: In vitro assessment of non-irritant microemulsified voriconazole hydrogel system.
abstract: Research was aimed on microemulsion-based hydrogel for voriconazole. Oleic acid and isopropyl myristate as lipid phases; tween 20: tween 80 as surfactants and PEG600 as cosurfactant were selected to formulate voriconazole microemulsions. The promising microemulsions in terms of zeta potential, pH, viscosity, and drug release were selected and developed into hydrogels using carbopol 934. Resulting microemulsion-based hydrogel (MBH) of voriconazole were evaluated for in vitro diffusion and ex vivo permeation. Antifungal potentials of MBH were assessed against selected fungal strains. Optimal MBH formulations, O6 and O8 had displayed their antifungal potentials with enlarged zone of inhibition against selected fungal strains.
authors.affiliation: a Pharmaceutics Division , Sri Padmavathi School of Pharmacy , Tiruchanoor, Tirupati , India.
authors.forename: Prasanna
authors.initials: P
authors.lastname: Raju Y
authors.affiliation: a Pharmaceutics Division , Sri Padmavathi School of Pharmacy , Tiruchanoor, Tirupati , India.
authors.forename: Hyndavi
authors.initials: H
authors.lastname: N
authors.affiliation: b Pharmaceutics Division , PES College of Pharmacy , Bangalore , India.
authors.forename: Harini
authors.initials: H
authors.lastname: Chowdary V
authors.affiliation: c School of Pharmacy , The University of Nottingham Malaysia Campus, Jalan Broga, Semenyih , Selangor , Malaysia.
authors.forename: Rajesh S
authors.initials: RS
authors.lastname: Nair
authors.affiliation: b Pharmaceutics Division , PES College of Pharmacy , Bangalore , India.
authors.forename: Jamal
authors.initials: J
authors.lastname: Basha D
authors.affiliation: a Pharmaceutics Division , Sri Padmavathi School of Pharmacy , Tiruchanoor, Tirupati , India.
authors.forename: Tejeswari
authors.initials: T
authors.lastname: N
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology / Q000633:toxicity*; D004339:Drug Compounding; D004655:Emulsions; D020100:Hydrogels / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D008422:Materials Testing; D010539:Permeability; D051381:Rats; D012867:Skin / Q000187:drug effects; D012995:Solubility; D013501:Surface-Active Agents / Q000737:chemistry; D014783:Viscosity; D065819:Voriconazole / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology / Q000633:toxicity*
chemical_list: D000935:Antifungal Agents; D004655:Emulsions; D020100:Hydrogels; D013501:Surface-Active Agents; D065819:Voriconazole
keywords: Diffusion; MIC; membrane-transport; microemulsion; permeability