title: The RhoB small GTPase in physiology and disease.
abstract: RhoB is a Rho family GTPase that is highly similar to RhoA and RhoC, yet has distinct functions in cells. Its unique C-terminal region is subject to specific post-translational modifications that confer different localization and functions to RhoB. Apart from the common role with RhoA and RhoC in actin organization and cell migration, RhoB is also implicated in a variety of other cellular processes including membrane trafficking, cell proliferation, DNA-repair and apoptosis. RhoB is not an essential gene in mice, but it is implicated in several physiological and pathological processes. Its multiple roles will be discussed in this review.
authors.affiliation: a Instituto de Biomedicina de Sevilla, IBiS (Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla) , Sevilla , Spain.|b Department of Medical Physiology and Biophysics , Universidad de Sevilla , Sevilla , Spain.
authors.forename: Francisco M
authors.identifier: 0000-0002-9015-864X
authors.initials: FM
authors.lastname: Vega
authors.affiliation: c Randall Division of Cell and Molecular Biophysics, King's College London , New Hunt's House, Guy's Campus, London , UK.
authors.forename: Anne J
authors.identifier: 0000-0001-8186-5708
authors.initials: AJ
authors.lastname: Ridley
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D004194:Disease; D048788:Growth and Development; D006801:Humans; D009369:Neoplasms / Q000201:enzymology; D018919:Neovascularization, Physiologic; D020743:rhoB GTP-Binding Protein / Q000737:chemistry / Q000378:metabolism*
chemical_list: D020743:rhoB GTP-Binding Protein
keywords: Rho GTPases; RhoB; cancer progression; development; membrane trafficking