title: Modelling primary blast lung injury: current capability and future direction.
abstract: Primary blast lung injury frequently complicates military conflict and terrorist attacks on civilian populations. The fact that it occurs in areas of conflict or unpredictable mass casualty events makes clinical study in human casualties implausible. Research in this field is therefore reliant on the use of some form of biological or non-biological surrogate model. This article briefly reviews the modelling work undertaken in this field until now and describes the rationale behind the generation of an in silico physiological model.
authors.affiliation: Academic Department of Military Anaesthesia and Critical Care, Royal Centre for Defence Medicine, ICT Centre, Birmingham, UK.
authors.forename: Timothy
authors.initials: T
authors.lastname: Scott
authors.affiliation: Academic Department of Military Anaesthesia and Critical Care, Royal Centre for Defence Medicine, ICT Centre, Birmingham, UK.
authors.forename: E
authors.initials: E
authors.lastname: Hulse
authors.affiliation: Anaesthesia & Critical Care Research Group, Division of Clinical Neuroscience, Nottingham University Hospital, Queens Medical Centre, Nottingham, UK.
authors.forename: M
authors.initials: M
authors.lastname: Haque
authors.affiliation: Defence Science and Technology Laboratories, Salisbury, UK.
authors.forename: E
authors.initials: E
authors.lastname: Kirkman
authors.affiliation: Anaesthesia & Critical Care Research Group, Division of Clinical Neuroscience, Nottingham University Hospital, Queens Medical Centre, Nottingham, UK.
authors.forename: J
authors.initials: J
authors.lastname: Hardman
authors.affiliation: Academic Department of Military Anaesthesia and Critical Care, Royal Centre for Defence Medicine, ICT Centre, Birmingham, UK.
authors.forename: P
authors.initials: P
authors.lastname: Mahoney
mesh_terms: D001753:Blast Injuries; D003198:Computer Simulation; D006801:Humans; D055370:Lung Injury; D054527:Mass Casualty Incidents; D008887:Military Medicine; D008962:Models, Theoretical; D023481:Terrorism; D000067398:War-Related Injuries
keywords: blast; lung injury; modelling