title: The predictor of mortality outcome in adult patients with Ebola virus disease during the 2014-2015 outbreak in Guinea.
abstract: The purpose of this study was to examine the association of any demographic and clinical factors with mortality outcome among adult patients with Ebola virus disease (EVD) in Guinea. This retrospective observational study analyzed medical records of laboratory confirmed EVD adult patients during the 2014-2015 EVD outbreak in Guinea. The associations between any demographic or clinical variables and mortality outcome of EVD were assessed using univariate and multivariate logistic regression analyses. Of 2,310 EVD adult patients included for analysis, the overall case fatality rate was 68.1%. Univariate analyses identified factors possibly associated with mortality outcome, including patient age (p < 0.001), history of visiting or close contact with a suspected or confirmed EVD patient (p = 0.035), and seven clinical symptoms on admission, i.e., fever (p = 0.003), hiccups (p < 0.001), vomiting (p = 0.003), diarrhea (p < 0.001), cough (p = 0.001), sore throat (p = 0.016), and unexplained bleeding (p = 0.021). The multivariate analysis showed that patient age was independently associated with mortality outcome of EVD (OR = 1.06; 95%CI = 1.03-1.09; p < 0.001), while none the of clinical symptoms on admission were significantly associated with the mortality outcome. Our analysis indicates that older age was the only independent factor associated with death among EVD adult patients in Guinea. This suggests that older EVD patients should receive intensive medical care and be carefully monitored.
authors.affiliation: Faculty of Medicine, University Gamal Abdel Nasser of Conakry, Conakry, Guinea. msamafr@nagasaki-u.ac.jp.|Department of Immunogenetics, Institute of Tropical Medicine (NEKKEN), Nagasaki University, 1-12-4 Sakamoto, Nagasaki, 852-8523, Japan. msamafr@nagasaki-u.ac.jp.
authors.forename: M S
authors.initials: MS
authors.lastname: Cherif
authors.affiliation: Department of Immunogenetics, Institute of Tropical Medicine (NEKKEN), Nagasaki University, 1-12-4 Sakamoto, Nagasaki, 852-8523, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Koonrungsesomboon
authors.affiliation: Faculty of Medicine, University Gamal Abdel Nasser of Conakry, Conakry, Guinea.
authors.forename: M P
authors.initials: MP
authors.lastname: Diallo
authors.affiliation: Faculty of Medicine, University Gamal Abdel Nasser of Conakry, Conakry, Guinea.|Pôle Régional de Cancérologie Bretagne, Rennes, France.
authors.forename: E
authors.initials: E
authors.lastname: Le Gall
authors.affiliation: Faculty of Medicine, University Gamal Abdel Nasser of Conakry, Conakry, Guinea.
authors.forename: D
authors.initials: D
authors.lastname: Kassé
authors.affiliation: Ministry of Health and Public Hygiene, Conakry, Guinea.
authors.forename: F
authors.initials: F
authors.lastname: Cherif
authors.affiliation: Faculty of Medicine, University Gamal Abdel Nasser of Conakry, Conakry, Guinea.
authors.forename: A
authors.initials: A
authors.lastname: Koné
authors.affiliation: Faculty of Medicine, University Gamal Abdel Nasser of Conakry, Conakry, Guinea.
authors.forename: M
authors.initials: M
authors.lastname: Diakité
authors.affiliation: Faculty of Medicine, University Gamal Abdel Nasser of Conakry, Conakry, Guinea.
authors.forename: F
authors.initials: F
authors.lastname: Camara
authors.affiliation: Faculty of Medicine, University Gamal Abdel Nasser of Conakry, Conakry, Guinea.
authors.forename: N
authors.initials: N
authors.lastname: Magassouba
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000032:analysis; D004196:Disease Outbreaks; D005260:Female; D016701:Guinea / Q000453:epidemiology; D019142:Hemorrhagic Fever, Ebola / Q000175:diagnosis* / Q000453:epidemiology / Q000401:mortality* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009026:Mortality; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D016019:Survival Analysis; D055815:Young Adult
chemical_list: D015415:Biomarkers