title: MiR-146a rs2910164 polymorphism and head and neck carcinoma risk: a meta-analysis based on 10 case-control studies.
abstract: Two recent meta-analyses have been conducted on the relationship between miR-146a polymorphism (rs2910164) and head and neck cancer (HNC) risk. However, they have yielded conflicting results. Hence, the aim of the present study was to conduct a quantitative updated meta-analysis addressing this subject. Eligible studies up to Sep 2016 were retrieved and screened from the bio-databases and then essential data were extracted for data analysis. Next, subgroup analyses on ethnicity, source of controls, sample size, and genotyping method were also carried out. As a result, a total of 9 publications involving 10 independent case-control studies were included. The overall data indicated a significant association between miR-146a rs2910164 polymorphism and HNC risk [C vs. G: odds ratio (OR) = 1.14; 95% confidence interval (CI) = 1.00-1.31; CC+CG vs. GG: OR=1.21; 95%CI=1.02-1.43]. Variant alleles of miR-146a rs2910164 may have a correlation with increased HNC risk. Future well-designed studies containing large sample sizes are needed to verify this result.
authors.affiliation: Department of Otolaryngology, Southwest Hospital, Third Military Medical University, Chongqing, China.
authors.forename: Zhaolan
authors.initials: Z
authors.lastname: Xiang
authors.affiliation: Affiliated Hospital of Guizhou Medical University, Guiyang, China.
authors.forename: Jue
authors.initials: J
authors.lastname: Song
authors.affiliation: Department of Otolaryngology, Southwest Hospital, Third Military Medical University, Chongqing, China.
authors.forename: Xianlu
authors.initials: X
authors.lastname: Zhuo
authors.affiliation: Department of Otolaryngology, Southwest Hospital, Third Military Medical University, Chongqing, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Li
authors.affiliation: Department of Otolaryngology, Southwest Hospital, Third Military Medical University, Chongqing, China.
authors.forename: Xueyuan
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000483:Alleles; D002277:Carcinoma / Q000235:genetics*; D016022:Case-Control Studies; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006258:Head and Neck Neoplasms / Q000235:genetics*; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D017594:Publication Bias; D012306:Risk
chemical_list: C542542:MIRN146 microRNA, human; D035683:MicroRNAs
keywords: head and neck cancer; meta-analysis; miR-146a; polymorphism; susceptibility