title: Efficacy of Long-Acting Octreotide on Reducing Mucus Production in Patients With Ileal Neobladder.
abstract: To evaluate the efficacy of long-acting-release octreotide (trade name Sandostatin) on decreasing mucus secretion, thus reducing catheter obstruction after radical cystectomy and orthotopic reconstruction.
  
  
  
  In this double-blind, placebo-controlled study, we treated 73 cases of radical cystectomy between the years 2008 and 2014; 65 were deemed eligible for the study. Cases were randomly divided into 2 groups. Group A (n = 32) received 2 doses of 20 mg intramuscular long-acting-release octreotide 4 weeks before and on the day of surgery, while group B (n = 33) received placebo. Catheter irrigation was only performed when there was an obstruction due to a mucus plug. The need for catheter irrigation and the volume of mucus produced by the neobladder were evaluated and compared between the 2 groups.
  
  
  
  The average number of neobladder irrigations required to treat mucus plugs was 2.3 ± 1.5 in group A and 9.5 ± 4.3 in group B (P < .001) before hospital discharge. This number changed to 2.5 ± 1.5 versus 11.4 ± 2.7 in groups A and B, respectively (P < .001), after discharge from the hospital. The 24-hour mucus production at the end of the first week was 5.4 ± 2.7 mL versus 21.5 ± 5.6 mL in groups A and B, respectively (P < .001). At the end of the third week, this amount changed to 5.5 ± 2.3 mL versus 21.8 ± 5.6 mL in groups A and B, respectively (P < .001).
  
  
  
  Two injections of long-acting-release octreotide can dramatically reduce mucus production and hence catheter obstruction due to mucus plugs after radical cystectomy and orthotopic reconstruction.
authors.affiliation: Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Mohammad Hatef
authors.initials: MH
authors.lastname: Khorrami
authors.affiliation: Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address: amirjavid2000@yahoo.com.
authors.forename: Amir
authors.initials: A
authors.lastname: Javid
authors.affiliation: Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Mohammad Hossein
authors.initials: MH
authors.lastname: Izadpanahi
authors.affiliation: Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Farshid
authors.initials: F
authors.lastname: Alizadeh
authors.affiliation: Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Mahtab
authors.initials: M
authors.lastname: Zargham
authors.affiliation: Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Farbod
authors.initials: F
authors.lastname: Khorrami
mesh_terms: D000368:Aged; D015653:Cystectomy / Q000009:adverse effects*; D004311:Double-Blind Method; D005765:Gastrointestinal Agents / Q000008:administration & dosage* / Q000494:pharmacology; D006801:Humans; D007273:Injections, Intramuscular; D007430:Intraoperative Care; D008297:Male; D008875:Middle Aged; D009093:Mucus / Q000187:drug effects*; D015282:Octreotide / Q000008:administration & dosage* / Q000494:pharmacology; D016896:Treatment Outcome; D001749:Urinary Bladder Neoplasms / Q000601:surgery; D014547:Urinary Diversion / Q000009:adverse effects*
chemical_list: D005765:Gastrointestinal Agents; D015282:Octreotide
keywords: Catheter obstruction; Mucus plug; Octreotide; Orthotopic; Radical cystectomy