title: The expression of B7-H3 and B7-H4 in human gallbladder carcinoma and their clinical implications.
abstract: To investigate the expression of B7-H3 and B7-H4 and their clinical implications in human gallbladder carcinoma.
  
  
  
  The expression of B7-H3 and B7-H4 in the 252 samples (126 cases of chronic cholecystitis and 126 cases of gallbladder cancer) was detected by the streptavidin-peroxidase immunohistochemical method, and their associations with tumor classification, clinical grade, and recurrence were assessed.
  
  
  
  In chronic cholecystitis tissue, B7-H3 and B7-H4 were not detected. In 126 cases of gallbladder carcinoma, the positive rates of B7-H3 and B7-H4 expression were 66.67% and 69.05% respectively (p < 0.05). The positive rate of B7-H3 in the primary-onset group was 53.57%, and that in recurrence group was 92.86% (p < 0.05). The positive rate of B7-H4 in the primary-onset group was 85.19%, and that in recurrence group was 40.00% (p < 0.05). Expression of B7-H3 was consistent with B7-H4 expression in gallbladder carcinoma.
  
  
  
  B7-H3 and B7-H4 were up-regulated in gallbladder cancer; the high expression of B7-H3 may contribute to the early diagnosis of gallbladder carcinoma and the assessment of postoperative survival and recurrence. B7-H4 may play an important role in the incidence of gallbladder cancer. B7-H3 and B7-H4 may play a synergetic role in gallbladder carcinoma. Combined tests were available for the diagnosis, degree assessment and prognosis of gallbladder carcinoma, which may be a new target for molecular targeted therapy of gallbladder carcinoma.
authors.affiliation: Department of Hepatobiliary Surgery, Air Force General Hospital of PLA, Beijing, China. liuchengli8866@sina.com.
authors.forename: C-L
authors.initials: CL
authors.lastname: Liu
authors.forename: X-X
authors.initials: XX
authors.lastname: Zang
authors.forename: H
authors.initials: H
authors.lastname: Huang
authors.forename: H
authors.initials: H
authors.lastname: Zhang
authors.forename: C
authors.initials: C
authors.lastname: Wang
authors.forename: Y-L
authors.initials: YL
authors.lastname: Kong
authors.forename: H-Y
authors.initials: HY
authors.lastname: Zhang
mesh_terms: D060887:B7 Antigens / Q000378:metabolism; D002277:Carcinoma / Q000378:metabolism / Q000473:pathology; D005706:Gallbladder Neoplasms / Q000378:metabolism* / Q000473:pathology*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D011379:Prognosis
chemical_list: D060887:B7 Antigens