title: The Relationship Between Systemic Lupus Erythematosus Activity and Persistent Positive Antiphospholipid Antibodies.
abstract: BACKGROUND
  Systemic Lupus Erythematosus (SLE) is an autoimmune disorder, characterized by producing different auto-antibodies and multiorgan involvements. In this study we aimed to investigate the relationship between SLE activity and persistently positive antiphospholipid antibodies.
  
  
  OBJECTIVE
  Fifty-nine lupus patients (55 women and 4 men) who were assessed in two consecutive visits with 6 weeks interval were selected. Patients` clinical and laboratory data and serum antiphospholipid antibodies` values, were collected. Serum anticardiolipin antibodies and lupus anticoagulant were measured in two visits. The correlations between these antibodies with SLEDAI and with major organ involvements were assessed. We found that SLEDAI was significantly higher in persistently positive aPLs patients compared with persistently negative aPLs patients. A positive correlation between IgG-aCL antibody titer and SLEDAI at first visit (P=0.049) was also seen.
  
  
  CONCLUSIONS
  The results showed that disease activity in SLE was associated with increased APAs and persistent positive antiphospholipid antibodies may indicate higher lupus disease activity.
authors.affiliation: Rheumatic Diseases Research Center (RDRC), Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Zhaleh Shariati
authors.initials: ZS
authors.lastname: Sarabi
authors.affiliation: Rheumatic Diseases Research Center (RDRC), Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Sahebari
authors.affiliation: Department of Biomedical Science, Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064, United States.
authors.forename: Ali Etemad
authors.initials: AE
authors.lastname: Rezaie
authors.affiliation: Rheumatic Diseases Research Center (RDRC), Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Mohammad Taghi
authors.initials: MT
authors.lastname: Norouzi
authors.affiliation: Rheumatic Diseases Research Center (RDRC), Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Kamila
authors.initials: K
authors.lastname: Hashemzadeh
authors.affiliation: Rheumatic Diseases Research Center (RDRC), Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Mirfeizi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D017152:Antibodies, Antiphospholipid / Q000097:blood*; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008180:Lupus Erythematosus, Systemic / Q000097:blood* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D055815:Young Adult
chemical_list: D017152:Antibodies, Antiphospholipid
keywords: Antiphospholipid antibodies; IgG-aCL antibody; SLEDAI; autoimmune disorder; systemic lupus erythematosus.