title: Continuing fascination of exploration in natural substances from microorganisms.
abstract: In the search for novel organic compounds, I think it is of paramount importance not to overlook the pursuit of microorganism diversity and the abilities those microorganisms hold as a resource. In commemoration of Professor Satoshi Ōmura's Nobel Prize in Physiology or Medicine, I will briefly describe the microorganism that produces avermectin and then discuss how innovating isolation methods and pioneering isolation sources have opened the door to numerous new microorganism resources. Furthermore, as exploratory research of substances views the world from many different angles-from biological activity to a compound's physiochemical properties-it is possible to discover a novel compound from a well-known microorganism. Based on this, I will discuss the future prospects of exploratory research.
authors.affiliation: a Kitasato Institute for Life Sciences , Kitasato University , Tokyo , Japan.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Takahashi
mesh_terms: D001688:Biological Products / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D055598:Chemical Phenomena; D055808:Drug Discovery / Q000379:methods*; D007559:Ivermectin / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D008829:Microbiology
chemical_list: D001688:Biological Products; D007559:Ivermectin; C019264:avermectin
keywords: Natural compounds; physicochemical screening