title: Pathogenesis of COPD and Asthma.
abstract: Asthma and COPD remain two diseases of the respiratory tract with unmet medical needs. This review considers the current state of play with respect to what is known about the underlying pathogenesis of these two chronic inflammatory diseases of the lung. The review highlights why they are different conditions requiring different approaches to treatment and provides a backdrop for the subsequent chapters in this volume discussing recent advances in the pharmacology and treatment of asthma and COPD.
authors.affiliation: Sackler Institute of Pulmonary Pharmacology, King's College London, 150 Stamford Street, London, SE1 9NH, UK. clive.page@kcl.ac.uk.
authors.forename: Clive
authors.initials: C
authors.lastname: Page
authors.affiliation: Sackler Institute of Pulmonary Pharmacology, King's College London, 150 Stamford Street, London, SE1 9NH, UK.
authors.forename: Blaze
authors.initials: B
authors.lastname: O'Shaughnessy
authors.affiliation: Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College London, Dovehouse Street, London, SW3 6LY, UK.
authors.forename: Peter
authors.initials: P
authors.lastname: Barnes
mesh_terms: D000375:Aging; D056151:Airway Remodeling; D001249:Asthma / Q000209:etiology*; D016535:Bronchial Hyperreactivity / Q000209:etiology; D006801:Humans; D018384:Oxidative Stress; D029424:Pulmonary Disease, Chronic Obstructive / Q000209:etiology*
keywords: Asthma; Bronchial hyperresponsiveness; COPD; Pathogenesis