title: [Application of low dose CT angiography with 70 kV in patients with peripheral arterial diseases].
abstract: Objective:To assess the image quality, radiation dose and diagnostic efficiency of peripheral arterial CT angiography (CTA) performed at tube voltage of 70 and 120 kV.Methods:Between January 2014 and December 2015, a total of 200 consecutive patients with known or suspected lower extremity arteriosclerosis obliterans (LEASO) underwent CTA.Patients were randomly divided into 2 groups by different scanning protocols.Group A (n=100): 70 kV and 0.8 ml/kg contrast agent, group B (n=100): 120 kV and 100 ml contrast agent.The vessel enhancement, image noise, signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) of 3 segments were quantified for each protocol.30 patients in group A (420 vessels) and 28 patients in group B (384 vessels) confirmed by DSA.Based on vessel assessments, compared with DSA findings, the diagnostic efficacy of 70 kV and 120 kV protocols for the detection of stenoses over 50% was evaluated.The dose of radiation and contrast agent were recorded.Subjective image quality was evaluated.Results:The subjective image quality of segment crural of group A was significantly higher than that of group B (2.20±0.36 vs 1.72±0.34,P<0.01). The enhancement of 3 segments in group A (500 HU) were significantly higher than these in group B (310 HU) (P<0.05). For the detection of stenoses over 50%, the sensitivity, positive and negative predictive values and accuracy of segment crural in group A (98.6%, 95.8%, 98.1%, 96.7%) were significantly higher than that in group B (90.9%, 88.5%, 91.0%, 89.7%) (P<0.05). Mean DLP for 70-kV protocol was significantly lower than that for 120-kV protocol ( (396±34) vs (1 041±159) mGy·cm,P=0.001). Mean dose of contrast agent and the total amount of iodine for 70-kV protocol were significantly lower than that for 120-kV protocol (53.5 vs 100 ml; 18.7 vs 35 g;P<0.01).Conclusion:CT angiography of peripheral arteries with a low tube voltage of 70 kV and low dose of iodine provides reliable information and serves as a rapidly performed and easily available imaging modality in the diagnosis of LEASO.
authors.affiliation: Department of Radiology, Shandong Medical Imaging Research Institute, Shandong Provincial Key Laboratory of Diagnosis and Treatment of Cardiocerebral Vascular Disease, Shandong University, Jinan 250021, China.
authors.forename: Y H
authors.initials: YH
authors.lastname: Duan
authors.forename: G M
authors.initials: GM
authors.lastname: Lu
authors.forename: J
authors.initials: J
authors.lastname: Wu
authors.forename: X C
authors.initials: XC
authors.lastname: Yang
authors.forename: D D
authors.initials: DD
authors.lastname: Wu
authors.forename: Z P
authors.initials: ZP
authors.lastname: Cheng
authors.forename: X M
authors.initials: XM
authors.lastname: Wang
mesh_terms: D000072226:Computed Tomography Angiography; D006801:Humans; D058729:Peripheral Arterial Disease; D059629:Signal-To-Noise Ratio