title: Mild encephalitis/encephalopathy with reversible splenial lesion (MERS) due to dengue virus.
abstract: A 14-year-old girl presented with encephalopathy, delirium and ophthalmoplegia following a 3day history of high-grade fever. Brain MRI on day 6 of illness showed diffusion restricted ovoid lesion in the splenium of corpus callosum. Dengue virus encephalitis was diagnosed with positive PCR for dengue virus type-2 in both serum and cerebrospinal fluid. She made a complete recovery from day 10 of illness. Repeat brain MRI on day 12 of illness showed resolution of the splenial lesion. Serial diffusion tensor imaging (DTI) showed normal fractional anisotropy values on resolution of splenial lesion indicating that MERS was likely due to transient interstitial oedema with preservation of white matter tracts. This is the first reported case of MERS following dengue virus infection. It highlights the usefulness of performing serial DTI in understanding the underlying pathogenesis of MERS. Our case report widens the neurological manifestations associated with dengue infection and reiterates that patients with MERS should be managed supportively as the splenial white matter tracts are reversibly involved in MERS.
authors.affiliation: Division of Paediatric Neurology, Department of Paediatrics, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. Electronic address: cyfong@ummc.edu.my.
authors.forename: Choong Yi
authors.initials: CY
authors.lastname: Fong
authors.affiliation: Division of Paediatric Neurology, Department of Paediatrics, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia; Paediatric Neurology Unit, Yangon Children's Hospital, Yangon, Myanmar.
authors.forename: Mi Mi Ko
authors.initials: MM
authors.lastname: Khine
authors.affiliation: Biomedical Imaging Department, University of Malaya Medical Centre, Kuala Lumpur, Malaysia; Medical Imaging Department, Faculty of Medicine, Universiti Teknologi MARA, Selangor, Malaysia.
authors.forename: Alan Basil
authors.initials: AB
authors.lastname: Peter
authors.affiliation: Division of Paediatric Neurology, Department of Paediatrics, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
authors.forename: Wei Kang
authors.initials: WK
authors.lastname: Lim
authors.affiliation: Biomedical Imaging Department, University of Malaya Medical Centre, Kuala Lumpur, Malaysia.
authors.forename: Faizatul Izza
authors.initials: FI
authors.lastname: Rozalli
authors.affiliation: Biomedical Imaging Department, University of Malaya Medical Centre, Kuala Lumpur, Malaysia.
authors.forename: Kartini
authors.initials: K
authors.lastname: Rahmat
mesh_terms: D000293:Adolescent; D003337:Corpus Callosum / Q000000981:diagnostic imaging; D003715:Dengue / Q000150:complications*; D056324:Diffusion Tensor Imaging; D018792:Encephalitis, Viral / Q000000981:diagnostic imaging* / Q000209:etiology / Q000473:pathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D013154:Spleen / Q000473:pathology
keywords: Corpus callosum; Dengue; Encephalitis; Encephalopathy