title: Impact of serum uric acid, albumin and their interaction on Parkinson's disease.
abstract: The study aimed to investigate the correlation between Parkinson's disease (PD) and serum levels of uric acid (UA), albumin and their interaction. A cross-sectional study was conducted to evaluate the relationship of serum UA, albumin with PD. A total of 96 PD patients and 108 healthy controls were recruited at Huai'an First People's Hospital, Nanjing Medical University. Baseline data included age, gender, body mass index (BMI), disease duration, Hoehn and Yahr scale (H&Y) stage, serum UA and albumin levels. The levels of serum UA and albumin were significantly lower in PD patients than those in controls (P = 0.001; P = 0.000). Serum albumin levels were strikingly different in H&Y group (P = 0.004). Multivariable logistic regression showed that the levels of serum UA (P = 0.001, adjusted OR 0.993, 95% CI 0.988-0.997) and albumin (P = 0.000, adjusted OR 0.513, 95% CI 0.425-0.620) were independent risk factors in PD. The receiver operating characteristic (ROC) curve analyses showed that the area under curve (AUC) for serum UA and albumin was 0.669 (95% CI 0.594-0.744) and 0.883 (95% CI 0.835-0.931), respectively. The combination of serum albumin and UA improved the AUC to 0.898 (95% CI 0.854-0.942). Serum UA and albumin levels significantly decreased in PD patients and were independent risk factors for PD. More studies are needed to confirm our findings.
authors.affiliation: Department of Neurology, Huai'an First People's Hospital, Nanjing Medical University, 6 Beijing Road West, Huai'an, 223300, Jiangsu, China.
authors.forename: Lijun
authors.initials: L
authors.lastname: Wang
authors.affiliation: Center for Disease Control and Prevention of Huai'an City, Huai'an, 223001, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Hu
authors.affiliation: Department of Toxicology, School of Public Health, Nanjing Medical University, 818 Tianyuan East Road, Nanjing, 211166, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Toxicology, School of Public Health, Nanjing Medical University, 818 Tianyuan East Road, Nanjing, 211166, China.
authors.forename: Fangfang
authors.initials: F
authors.lastname: Fang
authors.affiliation: Department of Neurology, Huai'an First People's Hospital, Nanjing Medical University, 6 Beijing Road West, Huai'an, 223300, Jiangsu, China.
authors.forename: Guanliang
authors.initials: G
authors.lastname: Cheng
authors.affiliation: Department of Medical Laboratory, Huai'an First People's Hospital, Nanjing Medical University, 6 Beijing Road West, Huai'an, Jiangsu, 223300, China.
authors.forename: Yuzhang
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: Department of Toxicology, School of Public Health, Nanjing Medical University, 818 Tianyuan East Road, Nanjing, 211166, China. hxiao@njmu.edu.cn.
authors.forename: Hang
authors.initials: H
authors.lastname: Xiao
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, Jiangsu, China. qi_wan@126.com.
authors.forename: Qi
authors.initials: Q
authors.lastname: Wan
mesh_terms: D000368:Aged; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000097:blood*; D012307:Risk Factors; D012709:Serum Albumin / Q000378:metabolism*; D014527:Uric Acid / Q000097:blood*
chemical_list: D012709:Serum Albumin; D014527:Uric Acid
keywords: Interaction; Parkinson’s disease; Serum albumin; Serum uric acid