title: Further insight into prognostic factors in endometrial cancer: the new serum biomarker HE4.
abstract: Endometrial cancer (EC) is one of the most common gynecological cancer worldwide. To date, no good markers are routinely used in clinical practice for prognosis and monitoring. Areas covered: During the last years, an increasing interest in literature has been growing on HE4 (Human epididimis 4). Therefore, we aimed to gather all the evidence reported in literature analysing the potential prognostic value of HE4, compared to the well know tumor's features (histological type and grade, stage of disease, depth of myometrial invasion, lymphovascular space involvement and cervical involvement). Expert commentary: The analysis of data suggests that HE4 seems to have a good performance in prognosis and monitoring of the disease, helping to schedule the appropriste timing of imaging and surgery in a more individualized fashion. However, these findings surely require a validation in a larger cohorts of patients. Probably, in the next five years, prospective randomized trials will be performed to confirm the prognostic role of HE4 in EC and to find a tailored EC management strategy.
authors.affiliation: a Department of Obstetrics and Gynaecology, Campus Bio Medico , University of Rome , Rome , Italy.
authors.forename: Stella
authors.initials: S
authors.lastname: Capriglione
authors.affiliation: a Department of Obstetrics and Gynaecology, Campus Bio Medico , University of Rome , Rome , Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Plotti
authors.affiliation: a Department of Obstetrics and Gynaecology, Campus Bio Medico , University of Rome , Rome , Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Miranda
authors.affiliation: a Department of Obstetrics and Gynaecology, Campus Bio Medico , University of Rome , Rome , Italy.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Lopez
authors.affiliation: a Department of Obstetrics and Gynaecology, Campus Bio Medico , University of Rome , Rome , Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Scaletta
authors.affiliation: a Department of Obstetrics and Gynaecology, Campus Bio Medico , University of Rome , Rome , Italy.
authors.forename: Michele
authors.initials: M
authors.lastname: Moncelli
authors.affiliation: a Department of Obstetrics and Gynaecology, Campus Bio Medico , University of Rome , Rome , Italy.
authors.forename: Daniela
authors.initials: D
authors.lastname: Luvero
authors.affiliation: a Department of Obstetrics and Gynaecology, Campus Bio Medico , University of Rome , Rome , Italy.
authors.forename: Carlo
authors.initials: C
authors.lastname: De Cicco Nardone
authors.affiliation: a Department of Obstetrics and Gynaecology, Campus Bio Medico , University of Rome , Rome , Italy.
authors.forename: Corrado
authors.initials: C
authors.lastname: Terranova
authors.affiliation: a Department of Obstetrics and Gynaecology, Campus Bio Medico , University of Rome , Rome , Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Montera
authors.affiliation: a Department of Obstetrics and Gynaecology, Campus Bio Medico , University of Rome , Rome , Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Angioli
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood*; D016889:Endometrial Neoplasms / Q000097:blood / Q000473:pathology*; D005260:Female; D006801:Humans; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D011379:Prognosis; D011506:Proteins / Q000032:analysis*; D000081102:WAP Four-Disulfide Core Domain Protein 2
chemical_list: D014408:Biomarkers, Tumor; D011506:Proteins; D000081102:WAP Four-Disulfide Core Domain Protein 2; C569698:WFDC2 protein, human
keywords: Endometrial cancer; HE4; human epididimis 4; monitoring; prognosis