title: Perspectives on the role of Pannexin 1 in neural precursor cell biology.
abstract: We recently reported that targeted deletion of Pannexin 1 in neural precursor cells of the ventricular zone impairs the maintenance of these cells in healthy and stroke-injured brain. Here we frame this exciting new finding in the context of our previous studies on Pannexin 1 in neural precursors as well as the close relationship between Pannexin 1 and purinergic receptors established by other groups. Moreover, we identify important gaps in our understanding of Pannexin 1 in neural precursor cell biology in terms of the underlying molecular mechanisms and functional/behavioural outcomes.
authors.affiliation: Division of Medical Sciences, University of Victoria, Victoria, British Columbia, Canada.
authors.forename: Juan C
authors.identifier: 0000-0002-8061-7128
authors.initials: JC
authors.lastname: Sanchez-Arias
authors.affiliation: Division of Medical Sciences, University of Victoria, Victoria, British Columbia, Canada.
authors.forename: Leigh E
authors.identifier: 0000-0002-3235-4108
authors.initials: LE
authors.lastname: Wicki-Stordeur
authors.affiliation: Division of Medical Sciences, University of Victoria, Victoria, British Columbia, Canada; Island Medical Program and Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, British Columbia, Canada.
authors.forename: Leigh Anne
authors.identifier: 0000-0001-5852-3144
authors.initials: LA
authors.lastname: Swayne
keywords: ATP; cytoskeleton; neural precursor; pannexin; phagoptosis; proliferation; ventricular zone