title: Decline in Ocular Toxoplasmosis over 40 Years at a Tertiary Referral Practice in the United States.
abstract: OBJECTIVE
  To identify whether there has been a decline in ocular toxoplasmosis at a tertiary uveitis practice.
  
  
  METHODS
  Retrospective review of new patients at the University of Illinois Uveitis Service from 1973 to 2012.
  
  
  RESULTS
  There were 6820 patients with adequate records for inclusion; 323 (4.7%) were diagnosed with ocular toxoplasmosis. There was a 78.0% decline in prevalence of ocular toxoplasmosis from 2008 to 2012 compared with 1973 to 1977. Compared with the aggregate uveitis population, toxoplasmosis patients were more likely to be Hispanic (p<0.0001) and less likely to be African American (p<0.0001). Ocular toxoplasmosis in Hispanics commonly occurred in foreign-born patients (85.3%).
  
  
  CONCLUSIONS
  The diagnosis of ocular toxoplasmosis at our clinic declined, with Hispanics accounting for an increasing proportion of cases. These trends are consistent with the decreasing toxoplasmosis seropositivity in the United States, but may also reflect decreased referrals due to improved management of ocular toxoplasmosis in primary clinics.
authors.affiliation: a Department of Ophthalmology , Illinois Eye & Ear Infirmary , Chicago , Illinois, USA.
authors.forename: Joshua H
authors.initials: JH
authors.lastname: Hou
authors.affiliation: a Department of Ophthalmology , Illinois Eye & Ear Infirmary , Chicago , Illinois, USA.|b Department of Ophthalmology , Weill Cornell Medical College, New York , New York, USA.
authors.forename: Sarju S
authors.initials: SS
authors.lastname: Patel
authors.affiliation: a Department of Ophthalmology , Illinois Eye & Ear Infirmary , Chicago , Illinois, USA.
authors.forename: Asim V
authors.initials: AV
authors.lastname: Farooq
authors.affiliation: c Department of Pediatrics , Pritzer School of Medicine, University of Chicago, Chicago, Illinois, USA.
authors.forename: Asad A
authors.initials: AA
authors.lastname: Qadir
authors.affiliation: a Department of Ophthalmology , Illinois Eye & Ear Infirmary , Chicago , Illinois, USA.
authors.forename: Howard H
authors.initials: HH
authors.lastname: Tessler
authors.affiliation: a Department of Ophthalmology , Illinois Eye & Ear Infirmary , Chicago , Illinois, USA.|d Department of Ophthalmology , Feinberg School of Medicine - Northwestern Memorial Hospital , Chicago , Illinois , USA.
authors.forename: Debra A
authors.initials: DA
authors.lastname: Goldstein
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D005260:Female; D005544:Forecasting; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012189:Retrospective Studies; D017678:Sex Distribution; D062606:Tertiary Care Centers / Q000706:statistics & numerical data*; D014126:Toxoplasmosis, Ocular / Q000453:epidemiology*; D014481:United States / Q000453:epidemiology; D055815:Young Adult
keywords: Epidemiology; ocular infection; public health; seroprevalence; toxoplasmosis