title: Microvascular Blood Flow Improvement in Hyperglycemic Obese Adult Patients by Hypocaloric Diet.
abstract: The present study was aimed to assess the changes in skin microvascular blood flow (SBF) in newly diagnosed hyperglycemic obese subjects, administered with hypocaloric diet. Adult patients were recruited and divided in three groups: NW group (n=54), NG (n=54) and HG (n=54) groups were constituted by normal weight, normoglycemic and hyperglycemic obese subjects, respectively. SBF was measured by laser Doppler perfusion monitoring technique and oscillations in blood flow were analyzed by spectral methods under baseline conditions, at 3 and 6 months of dietary treatment. Under resting conditions, SBF was lower in HG group than in NG and NW ones. Moreover, all subjects showed blood flow oscillations with several frequency components. In particular, hyperglycemic obese patients revealed lower spectral density in myogenic-related component than normoglycemic obese and normal weight ones. Moreover, post-occlusive reactive hyperemia (PORH) was impaired in hyperglycemic obese compared to normoglycemic and normal weigh subjects. After hypocaloric diet, in hyperglycemic obese patients there was an improvement in SBF accompanied by recovery in myogenic-related oscillations and arteriolar responses during PORH. In conclusion, hyperglycemia markedly affected peripheral microvascular function; hypocaloric diet ameliorated tissue blood flow.
authors.affiliation: Department of Clinical Medicine and Surgery, "Federico II" University Medical School, Naples, Italy.
authors.forename: T
authors.initials: T
authors.lastname: Mastantuono
authors.affiliation: Department of Clinical Medicine and Surgery, "Federico II" University Medical School, Naples, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Di Maro
authors.affiliation: Department of Clinical Medicine and Surgery, "Federico II" University Medical School, Naples, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Chiurazzi
authors.affiliation: Department of Clinical Medicine and Surgery, "Federico II" University Medical School, Naples, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Battiloro
authors.affiliation: Department of Clinical Medicine and Surgery, "Federico II" University Medical School, Naples, Italy.
authors.forename: N
authors.initials: N
authors.lastname: Starita
authors.affiliation: Department of Clinical Medicine and Surgery, "Federico II" University Medical School, Naples, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Nasti
authors.affiliation: Department of Clinical Medicine and Surgery, "Federico II" University Medical School, Naples, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Lapi
authors.affiliation: Department of Biomedical, Electronics and TLC Engineering, University of Naples, "Federico II", Naples, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Iuppariello
authors.affiliation: Department of Biomedical, Electronics and TLC Engineering, University of Naples, "Federico II", Naples, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Cesarelli
authors.affiliation: IRCCS S. Maugeri Foundation, Telese, Benevento, Italy.
authors.forename: G
authors.initials: G
authors.lastname: D'Addio
authors.affiliation: Department of Clinical Medicine and Surgery, "Federico II" University Medical School, Naples, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Colantuoni
keywords: hyperglycemia; hypocaloric diet; laser Doppler perfusion monitoring; microvascular blood flow; obesity