title: Single-Tablet Regimens for the Treatment of HIV-1 Infection.
abstract: OBJECTIVE
  To review the pharmacokinetics, safety, drug-drug interactions, and advantages and disadvantages of currently available single-tablet regimens (STRs) for HIV-1 infection.
  
  
  METHODS
  A search using PubMed was conducted (up to September 2016) using the following keywords: single tablet regimen AND HIV. Additionally, a PubMed search was conducted for each individual STR using the generic names of the agents. Articles were evaluated for content, and additional references were identified from a review of literature citations.
  
  
  METHODS
  Studies included were predominantly phase III clinical trials with the exception of tenofovir alafenamide because phase I and phase II trials were also relevant for this new antiretroviral agent.
  
  
  RESULTS
  Six STRs are currently available for the treatment of HIV-1. Each agent has unique pharmacokinetic, safety, and drug-drug interaction profiles that result in distinct advantages and disadvantages. Three of these agents are first-line recommended therapies per national guidelines because of high virological efficacy and tolerability.
  
  
  CONCLUSIONS
  STRs have significantly advanced HIV management by minimizing pill burden and improving patient compliance. It is important to consider the nuances of each STR in regard to renal and hepatic function, drug interactions, and tolerability, to ensure safe and effective use.
authors.affiliation: 1 Wingate University School of Pharmacy, Wingate, NC, USA.
authors.forename: Jamielynn C
authors.initials: JC
authors.lastname: Sebaaly
authors.affiliation: 2 University of Florida Health Jacksonville, Jacksonville, FL, USA.
authors.forename: Denise
authors.initials: D
authors.lastname: Kelley
mesh_terms: D019380:Anti-HIV Agents / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D004338:Drug Combinations; D004347:Drug Interactions; D015658:HIV Infections / Q000188:drug therapy*; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D013607:Tablets
chemical_list: D019380:Anti-HIV Agents; D004338:Drug Combinations; D013607:Tablets
keywords: HIV/AIDS; adherence; antiretrovirals; dosage forms; drug interactions