title: Neural Signaling Metabolites May Modulate Energy Use in Hibernation.
abstract: Despite an epidemic in obesity and metabolic syndrome limited means exist to effect adiposity or metabolic rate other than life style changes. Here we review evidence that neural signaling metabolites may modulate thermoregulatory pathways and offer novel means to fine tune energy use. We extend prior reviews on mechanisms that regulate thermogenesis and energy use in hibernation by focusing primarily on the neural signaling metabolites adenosine, AMP and glutamate.
authors.affiliation: Department of Chemistry and Biochemistry, Institute of Arctic Biology, University of Alaska Fairbanks, 902 N. Koyukuk Drive, Fairbanks, AK, 99775, USA. kdrew@alaska.edu.
authors.forename: Kelly L
authors.identifier: http://orcid.org/0000-0002-2436-5720
authors.initials: KL
authors.lastname: Drew
authors.affiliation: Department of Chemistry and Biochemistry, Institute of Arctic Biology, University of Alaska Fairbanks, 902 N. Koyukuk Drive, Fairbanks, AK, 99775, USA.
authors.forename: Carla
authors.initials: C
authors.lastname: Frare
authors.affiliation: Department of Chemistry and Biochemistry, Institute of Arctic Biology, University of Alaska Fairbanks, 902 N. Koyukuk Drive, Fairbanks, AK, 99775, USA.
authors.forename: Sarah A
authors.initials: SA
authors.lastname: Rice
mesh_terms: D000818:Animals; D001831:Body Temperature / Q000502:physiology*; D001833:Body Temperature Regulation / Q000502:physiology*; D004734:Energy Metabolism / Q000502:physiology*; D006605:Hibernation / Q000502:physiology*; D006801:Humans; D009474:Neurons / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
keywords: Adenosine; Arctic ground squirrel; Glutamate; Obesity; Thermoregulation; Torpor