title: Clinical Assessment of Histidine-Tryptophan-Ketoglutarate Solution and Modified St. Thomas' Solution in Pediatric Cardiac Surgery of Tetralogy of Fallot.
abstract: The objective of this study is to compare the myocardium protective effect of Bretschneider's histidine-tryptophan-ketoglutarate (HTK) solution versus Modified St. Thomas' (STH) solution in pediatric cardiac surgery of Tetralogy of Fallot (TOF). Seventy-seven pediatric patients of TOF who received the total surgical repair were reviewed, from January 2014 to October 2015. A horizontal comparison between HTK solution and modified STH solution has been made since the HTK solutions were started to be used in our hospital. The patients were divided into the HTK group (n = 35) and the STH group (n = 33). The perioperative values of the groups were assessed in this study. The primary endpoints including spontaneous cardiac re-beating time, intensive care unit (ICU) stay, overall stay, mechanical ventilation postoperation, postoperation stay, overall stay, and perioperative echocardiographic results were analyzed in this study. We found that spontaneous cardiac re-beating time of the HTK group was significantly shorter than that of the STH group (0.26 min ± 0.56 vs. 1.33 ± 1.02, P < 0.001). There were no significant differences between the two groups in ICU stay (P = 0.29), postoperative mechanical ventilation time (P = 0.84), overall stay (0.73); and the mortalities of the two groups were similar (2.9 vs. 3.0%). Aimed at pediatric cardiac surgery of TOF, this study suggests that with similar aorta cross-clamping time, modified STH solution is as safe as HTK solution.
authors.affiliation: Department of Cardiac Surgery, People's Hospital of Dongyang, Dongyang.
authors.forename: Zhao-Hui
authors.initials: ZH
authors.lastname: Wang
authors.affiliation: Department of Cardiothoracic Surgery, Children's Hospital of Chongqing Medical University.
authors.forename: Yong
authors.initials: Y
authors.lastname: An
authors.affiliation: Department of Cardiothoracic Surgery, Children's Hospital of Chongqing Medical University.
authors.forename: Ming-Cheng
authors.initials: MC
authors.lastname: Du
authors.affiliation: Department of Cardiothoracic Surgery, Children's Hospital of Chongqing Medical University.
authors.forename: Ting-Jiang
authors.initials: TJ
authors.lastname: Qin
authors.affiliation: Department of Cardiothoracic Surgery, Children's Hospital of Chongqing Medical University.
authors.forename: Yin-Bei
authors.initials: YB
authors.lastname: Liu
authors.affiliation: Department of Anesthesiology and Cardiovascular Perfusion, Children's Hospital of Chongqing Medical University, Chongqing, R.P. China.
authors.forename: Hong-Zhen
authors.initials: HZ
authors.lastname: Xu
authors.affiliation: Department of Anesthesiology and Cardiovascular Perfusion, Children's Hospital of Chongqing Medical University, Chongqing, R.P. China.
authors.forename: Li-Qun
authors.initials: LQ
authors.lastname: Yang
mesh_terms: D000293:Adolescent; D000328:Adult; D001639:Bicarbonates / Q000627:therapeutic use; D002122:Calcium Chloride / Q000627:therapeutic use; D002314:Cardioplegic Solutions / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005947:Glucose / Q000627:therapeutic use; D006321:Heart / Q000187:drug effects*; D006324:Heart Arrest, Induced / Q000379:methods; D006801:Humans; D007223:Infant; D008274:Magnesium / Q000627:therapeutic use; D008297:Male; D008353:Mannitol / Q000627:therapeutic use; D009200:Myocardial Contraction / Q000187:drug effects; D011189:Potassium Chloride / Q000627:therapeutic use; D011343:Procaine / Q000627:therapeutic use; D012965:Sodium Chloride / Q000627:therapeutic use; D013771:Tetralogy of Fallot / Q000601:surgery*; D055815:Young Adult
chemical_list: D001639:Bicarbonates; C039984:Bretschneider cardioplegic solution; D002314:Cardioplegic Solutions; C041711:St. Thomas' Hospital cardioplegic solution; D008353:Mannitol; D012965:Sodium Chloride; D011343:Procaine; D011189:Potassium Chloride; D008274:Magnesium; D005947:Glucose; D002122:Calcium Chloride
keywords: -Cardioplegia; -Tetralogy of Fallot; Congenital heart disease