title: Hyperemesis gravidarum and placental dysfunction disorders.
abstract: Evidence about the consequence of hyperemesis gravidarum (HG) on pregnancy outcomes is still inconclusive. In this study, we evaluated if occurrence of hyperemesis gravidarum is associated with placental dysfunction disorders and neonatal outcomes.
  
  
  
  A prospective cohort study was conducted in a maternal and child health primary care referral center, Budi Kemuliaan Hospital and its branch, in Jakarta, Indonesia. 2252 pregnant women visiting the hospital for regular antenatal care visits from July 2012 until October 2014 were included at their first clinic visit. For women without, with mild and with severe hyperemesis, placental dysfunction disorders (gestational hypertension, preeclampsia (PE), stillbirth, miscarriage), neonatal outcomes (birth weight, small for gestational age (SGA), low birth weight (LBW), Apgar score at 5 min, gestational age at delivery) and placental outcomes (placental weight and placental-weight-to-birth-weight ratio (PW/BW ratio)) were studied.
  
  
  
  Compared to newborns of women without hyperemesis, newborns of women with severe hyperemesis had a 172 g lower birth weight in adjusted analysis (95%CI -333.26; -10.18; p = 0.04). There were no statistically significant effects on placental dysfunction disorders or other neonatal outcome measures.
  
  
  
  The results of our study suggest that hyperemesis gravidarum does not seem to induce placental dysfunction disorders, but does, if severe lead to lower birth weight.
authors.affiliation: Julius Center for Health Sciences and Primary Care, Global Health, University Medical Center Utrecht, Huispost Str. 6.131, PO Box 855500, 3508, GA, Utrecht, The Netherlands.
authors.forename: Heleen M
authors.initials: HM
authors.lastname: Koudijs
authors.affiliation: Julius Center for Health Sciences and Primary Care, Global Health, University Medical Center Utrecht, Huispost Str. 6.131, PO Box 855500, 3508, GA, Utrecht, The Netherlands. aryisavitri@gmail.com.
authors.forename: Ary I
authors.initials: AI
authors.lastname: Savitri
authors.affiliation: Julius Center for Health Sciences and Primary Care, Global Health, University Medical Center Utrecht, Huispost Str. 6.131, PO Box 855500, 3508, GA, Utrecht, The Netherlands.
authors.forename: Joyce L
authors.initials: JL
authors.lastname: Browne
authors.affiliation: Budi Kemuliaan Hospital, Jakarta, Indonesia.
authors.forename: Dwirani
authors.initials: D
authors.lastname: Amelia
authors.affiliation: Budi Kemuliaan Hospital, Jakarta, Indonesia.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Baharuddin
authors.affiliation: Julius Center for Health Sciences and Primary Care, Global Health, University Medical Center Utrecht, Huispost Str. 6.131, PO Box 855500, 3508, GA, Utrecht, The Netherlands.
authors.forename: Diederick E
authors.initials: DE
authors.lastname: Grobbee
authors.affiliation: Julius Center for Health Sciences and Primary Care, Global Health, University Medical Center Utrecht, Huispost Str. 6.131, PO Box 855500, 3508, GA, Utrecht, The Netherlands.
authors.forename: Cuno S P M
authors.initials: CS
authors.lastname: Uiterwaal
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D006939:Hyperemesis Gravidarum / Q000150:complications*; D007214:Indonesia / Q000453:epidemiology; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D010922:Placenta Diseases / Q000453:epidemiology* / Q000209:etiology*; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology*; D011446:Prospective Studies
keywords: Hyperemesis gravidarum; Offspring; Placental dysfunction disorders; Pregnancy