title: Occurrence of perfluoroalkyl substances in cord serum and association with growth indicators in newborns from Beijing.
abstract: Perfluoroalkyl substances (PFASs), a group of environmental pollutants, persistently exist in the environment. To investigate the associations between PFASs levels in cord serum and birth weight, birth length and ponderal index, we measured PFASs in cord serum samples from 170 infants from Feb. 2012 to Jun. 2012 in Beijing, China. The mean concentrations in cord serum samples for perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), perfluorohexane sulfonic acid (PFHxS), perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA) and perfluoroundecanoic acid (PFUnA) were 1.285 ng/mL, 1.228 ng/mL, 0.230 ng/mL, 0.224 ng/mL, 0.100 ng/mL and 0.085 ng/mL, respectively. First-born children had slightly higher exposure levels of PFHxS (p < 0.001) and PFOA (p = 0.03) than second-born or third-born children. The spearman correlation coefficients with gestation time were individually 0.160 (p = 0.038) for PFHxS and 0.202 (p = 0.008) for PFOA. Both univariate and multivariate linear regression analysis showed that the exposure levels of PFASs had no statistically significant associations with birth weight, birth length or ponderal index in the present population. For male infants, we observed that PFHxS positively correlated with birth length, but the levels of PFUnA were negatively associated with birth length.
authors.affiliation: Key Laboratory of Food Safety Risk Assessment, Ministry of Health and China National Center for Food Safety Risk Assessment, No. 7, Panjiayuannanli, 100021, Beijing, China; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Cancer Epidemiology, Peking University Cancer Hospital & Institute, 52 Fu-Cheng Road, Haidian District, Beijing, 100142, China; National Institute of Nutrition and Health, Chinese Centre for Disease Control and Prevention, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Shi
authors.affiliation: Key Laboratory of Food Safety Risk Assessment, Ministry of Health and China National Center for Food Safety Risk Assessment, No. 7, Panjiayuannanli, 100021, Beijing, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Yang
authors.affiliation: Key Laboratory of Food Safety Risk Assessment, Ministry of Health and China National Center for Food Safety Risk Assessment, No. 7, Panjiayuannanli, 100021, Beijing, China. Electronic address: lijg@cfsa.net.cn.
authors.forename: Jingguang
authors.initials: J
authors.lastname: Li
authors.affiliation: National Institute of Nutrition and Health, Chinese Centre for Disease Control and Prevention, China.
authors.forename: Jianqiang
authors.initials: J
authors.lastname: Lai
authors.affiliation: Key Laboratory of Food Safety Risk Assessment, Ministry of Health and China National Center for Food Safety Risk Assessment, No. 7, Panjiayuannanli, 100021, Beijing, China.
authors.forename: Yuxin
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Key Laboratory of Food Safety Risk Assessment, Ministry of Health and China National Center for Food Safety Risk Assessment, No. 7, Panjiayuannanli, 100021, Beijing, China.
authors.forename: Yunfeng
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Key Laboratory of Food Safety Risk Assessment, Ministry of Health and China National Center for Food Safety Risk Assessment, No. 7, Panjiayuannanli, 100021, Beijing, China. Electronic address: wuyongning@cfsa.net.cn.
authors.forename: Yongning
authors.initials: Y
authors.lastname: Wu
mesh_terms: D000328:Adult; D017738:Alkanesulfonic Acids / Q000097:blood; D000068476:Beijing; D001724:Birth Weight; D002210:Caprylates / Q000097:blood; D002648:Child; D002681:China; D003652:Decanoic Acids / Q000097:blood; D004785:Environmental Pollutants / Q000097:blood*; D005227:Fatty Acids / Q000097:blood; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D005466:Fluorocarbons / Q000097:blood*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D016014:Linear Models; D008297:Male; D018811:Maternal Exposure; D011247:Pregnancy; D013451:Sulfonic Acids / Q000097:blood*; D011795:Surveys and Questionnaires; D013995:Time
chemical_list: D017738:Alkanesulfonic Acids; D002210:Caprylates; D003652:Decanoic Acids; D004785:Environmental Pollutants; D005227:Fatty Acids; D005466:Fluorocarbons; D013451:Sulfonic Acids; C586085:perfluoroundecanoic acid; C036567:perfluorodecanoic acid; C471071:perfluorohexanesulfonic acid; C101816:perfluoro-n-nonanoic acid; C023036:perfluorooctanoic acid; C076994:perfluorooctane sulfonic acid; C078626:perflexane
keywords: Cord serum; Fetal growth; Perfluoroalkyl substances; Prenatal exposure