title: Association Between Severity of Obstructive Sleep Apnea and Number and Sites of Upper Airway Operations With Surgery Complications.
abstract: In patients with obstructive sleep apnea (OSA), operative risks depend on the severity of the underlying OSA and the invasiveness of the surgical procedure.
  
  
  
  To investigate the nature of the associations between the severity of OSA and the number and anatomical sites of upper airway operations with operative complications.
  
  
  
  This retrospective study included adult patients diagnosed with OSA (apnea-hypopnea index [AHI], >5) who underwent upper airway surgery at a single tertiary referral hospital between October 1, 2008, and October 1, 2015.
  
  
  
  All patients underwent single or combination surgery on the nose, palatopharyngeal (tonsils, adenoids, and soft palate), and tongue base as a treatment of OSA.
  
  
  
  Pulmonary, surgical, and cardiovascular complications within the first 30 postoperative days were analyzed according to OSA severity and types of upper airway surgery. Logistic regression was used to assess the multivariable association of OSA, age, sex, body mass index, medical comorbidities, and types of upper airway surgery with short-term operative complications.
  
  
  
  The study included 95 patients (87 males [91.6%]; 83 were Malay [87.4%]; mean [SD] age, 37.7 [1.6] years) with complete data and follow-up who underwent upper airway surgery to treat OSA. Patients with more severe OSA had greater body mass index (Cohen d, 0.27; 95% CI, -0.28 to 0.82), longer surgical time (Cohen d, 1.57; 95% CI, 0.95-2.15), and older age (Cohen d, 3.06; 95% CI, 2.29-3.77). At least 1 operative complication occurred in 48 of 95 patients (51%). In a multivariable model, the overall complication rate was increased with age and body mass index. Complication rates were not associated with AHI severity, type of procedure performed, and whether the surgery was single or combination surgery. Lowest oxygen desaturation (odds ratio, 1.03; 95% CI, 0.96-1.45; P = .04) and longest apnea duration (odds ratio, 1.03; 95% CI, 0.99-1.08; P = .02) were polysomnographic variables that predict the short-term operative complications.
  
  
  
  In patients with OSA undergoing upper airway surgery, the severity of OSA as assessed by AHI, and the sites and numbers of concurrent operations performed were not associated with the rate of short-term operative complications.
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, International Islamic University Malaysia, Jalan Hospital, Kuantan, Pahang, Malaysia.
authors.forename: Zamzil Amin
authors.initials: ZA
authors.lastname: Asha'ari
authors.affiliation: Department of Community Medicine, International Islamic University Malaysia, Jalan Hospital, Kuantan, Pahang, Malaysia.
authors.forename: Jamalludin Ab
authors.initials: JA
authors.lastname: Rahman
authors.affiliation: Department of Anaesthesiology, International Islamic University Malaysia, Jalan Hospital, Kuantan, Pahang, Malaysia.
authors.forename: Abdul Hadi
authors.initials: AH
authors.lastname: Mohamed
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, International Islamic University Malaysia, Jalan Hospital, Kuantan, Pahang, Malaysia.
authors.forename: Kahairi
authors.initials: K
authors.lastname: Abdullah
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, International Islamic University Malaysia, Jalan Hospital, Kuantan, Pahang, Malaysia.
authors.forename: Wan Ishlah
authors.initials: WI
authors.lastname: Leman
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D011183:Postoperative Complications / Q000209:etiology*; D012086:Reoperation; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D020181:Sleep Apnea, Obstructive / Q000175:diagnosis* / Q000209:etiology / Q000601:surgery*; D012959:Socioeconomic Factors