title: Osteitis: a retrospective feasibility study comparing single-source dual-energy CT to MRI in selected patients with suspected acute gout.
abstract: OBJECTIVE
  Dual-energy computed tomography detects tophi in patients with chronic gout. However, other information that can be obtained from the same scan is not the focus of the current research, e.g., the detection of bone marrow edema (BME) using virtual bone marrow imaging (VBMI). The aim of this study was to evaluate if BME in patients with acute arthritis can be detected with VBMI using magnetic resonance imaging (MRI) as the standard of reference.
  
  
  METHODS
  This retrospective study included 11 patients who underwent both MRI and dual-energy computed tomography (mean interval of 40 days). BME in MRI (standard of reference) and VBMI was judged independently by two different blinded readers. φ-correlation coefficient and Cohen's κ were performed for statistical analysis. Approval was waived by the IRB.
  
  
  RESULTS
  Two patients with a final diagnosis of RA and one with septic arthritis showed osteitis on MRI and VBMI. However, in each case, there were individual bones identified with osteitis on MRI but not VBMI. Three additional patients with the final diagnosis of RA were identified correctly as negative for BME. There was a good correlation between both modalities (φ = 0.8; κ = 0.8). Inter-rater reliability was excellent for both modalities (κ = 0.9).
  
  
  CONCLUSIONS
  We have shown that detecting osteitis using VBMI is feasible in patients with inflammatory arthritis. Further studies are needed on larger, more-targeted populations to better define the indications, accuracy, and added value of this technique.
authors.affiliation: Department of Radiology, Charité - Universitätsmedizin Berlin Campus Mitte, Humboldt-Universität zu Berlin, Freie Universität Berlin, Berlin, Germany. torsten.diekhoff@charite.de.|Department of Radiology (CCM), Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany. torsten.diekhoff@charite.de.
authors.forename: Torsten
authors.identifier: http://orcid.org/0000-0003-3593-1449
authors.initials: T
authors.lastname: Diekhoff
authors.affiliation: Department of Radiology, Charité - Universitätsmedizin Berlin Campus Mitte, Humboldt-Universität zu Berlin, Freie Universität Berlin, Berlin, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Scheel
authors.affiliation: Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin Campus Mitte, Berlin, Germany.
authors.forename: Sandra
authors.initials: S
authors.lastname: Hermann
authors.affiliation: Toshiba Medical Systems Europe, BV, Zilverstraat 1, 2701RP, Zoetermeer, Netherlands.
authors.forename: Jürgen
authors.initials: J
authors.lastname: Mews
authors.affiliation: Department of Radiology, Charité - Universitätsmedizin Berlin Campus Mitte, Humboldt-Universität zu Berlin, Freie Universität Berlin, Berlin, Germany.
authors.forename: Bernd
authors.initials: B
authors.lastname: Hamm
authors.affiliation: Department of Radiology, Charité - Universitätsmedizin Berlin Campus Mitte, Humboldt-Universität zu Berlin, Freie Universität Berlin, Berlin, Germany.
authors.forename: Kay-Geert A
authors.initials: KA
authors.lastname: Hermann
mesh_terms: D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D001172:Arthritis, Rheumatoid / Q000000981:diagnostic imaging*; D001853:Bone Marrow / Q000000981:diagnostic imaging*; D003937:Diagnosis, Differential; D004487:Edema / Q000000981:diagnostic imaging*; D005240:Feasibility Studies; D005260:Female; D006073:Gout / Q000000981:diagnostic imaging*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010000:Osteitis / Q000000981:diagnostic imaging*; D015203:Reproducibility of Results; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed / Q000379:methods*
keywords: Bone marrow edema; Dual-energy computed tomography; Inflammation; Postprocessing