title: An impressive response to pazopanib in a patient with metastatic endometrial carcinoma.
abstract: The incidence of endometrial carcinoma is rising and the patients with distant metastases have a poor prognosis, especially when progression of disease occurs after systemic treatment with hormonal therapy or chemotherapy. Pazopanib, a multi-targeted inhibitor of several oncogenic receptor tyrosine kinases, has been investigated in patients with chemotherapy-resistant endometrial carcinoma or patients for whom chemotherapy is contraindicated. In this report we will describe a spectacular response to pazopanib in a patient with recurrent metastatic endometrial carcinoma.
authors.affiliation: First auteur: Department of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands Second auteur: Gynaecological Oncology, Amsterdam Medical Centre, Amsterdam, the Netherlands.
authors.forename: M J
authors.initials: MJ
authors.lastname: van der Steen
authors.forename: Y R P
authors.initials: YR
authors.lastname: de Waal
authors.forename: A
authors.initials: A
authors.lastname: Westermann
authors.forename: B
authors.initials: B
authors.lastname: Tops
authors.forename: W
authors.initials: W
authors.lastname: Leenders
authors.forename: P B
authors.initials: PB
authors.lastname: Ottevanger
mesh_terms: D034861:Abdominal Wall; D020533:Angiogenesis Inhibitors / Q000627:therapeutic use*; D018269:Carcinoma, Endometrioid / Q000188:drug therapy* / Q000556:secondary; D059186:Chemoradiotherapy, Adjuvant; D016889:Endometrial Neoplasms / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006801:Humans; D007044:Hysterectomy; D007191:Indazoles; D007412:Intestinal Fistula; D008875:Middle Aged; D009362:Neoplasm Metastasis; D010052:Ovariectomy; D011743:Pyrimidines / Q000627:therapeutic use*; D012074:Remission Induction; D058994:Salpingectomy; D012983:Soft Tissue Neoplasms / Q000188:drug therapy* / Q000556:secondary; D013449:Sulfonamides / Q000627:therapeutic use*
chemical_list: D020533:Angiogenesis Inhibitors; D007191:Indazoles; D011743:Pyrimidines; D013449:Sulfonamides; C516667:pazopanib