title: Cycling through developmental decisions: how cell cycle dynamics control pluripotency, differentiation and reprogramming.
abstract: A strong connection exists between the cell cycle and mechanisms required for executing cell fate decisions in a wide-range of developmental contexts. Terminal differentiation is often associated with cell cycle exit, whereas cell fate switches are frequently linked to cell cycle transitions in dividing cells. These phenomena have been investigated in the context of reprogramming, differentiation and trans-differentiation but the underpinning molecular mechanisms remain unclear. Most progress to address the connection between cell fate and the cell cycle has been made in pluripotent stem cells, in which the transition through mitosis and G1 phase is crucial for establishing a window of opportunity for pluripotency exit and the initiation of differentiation. This Review will summarize recent developments in this area and place them in a broader context that has implications for a wide range of developmental scenarios.
authors.affiliation: Institute of Stem Cell Research, MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, UK sdalton@uga.edu Abdenour.Soufi@ed.ac.uk.
authors.forename: Abdenour
authors.initials: A
authors.lastname: Soufi
authors.affiliation: Center for Molecular Medicine and Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA sdalton@uga.edu Abdenour.Soufi@ed.ac.uk.
authors.forename: Stephen
authors.identifier: 0000-0002-3450-1263
authors.initials: S
authors.lastname: Dalton
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000502:physiology*; D065150:Cellular Reprogramming / Q000502:physiology*; D053595:Embryonic Stem Cells / Q000166:cytology*; D016193:G1 Phase / Q000502:physiology*; D006801:Humans; D008938:Mitosis / Q000502:physiology*; D039904:Pluripotent Stem Cells / Q000166:cytology*
keywords: Cell cycle; Cell fate; Differentiation; Pluripotency; Reprogramming; Stem cells