title: A single-center retrospective study of pediatric hepatoblastoma.
abstract: Hepatoblastoma is a malignant liver tumor generally diagnosed in infants and children <3 years old. The current retrospective study aimed to investigate the associations of tumor stage, pathological type, metastasis and chemotherapy with clinical outcomes. In the current study, a total of 102 patients with hepatoblastoma were enrolled between September 2006 and June 2014. Clinical records and follow-up information for each of patient were obtained to conduct a Kaplan-Meier survival analysis and log-rank test. The median age of the subjects was 1.5 years, and 98 patients had stage III or IV hepatoblastoma. Complete or partial remittance occurred in 72 subjects, and 91 underwent surgical operation. The survival rate differed significantly among patients with different tumor stages (P=0.015, χ2=8.359). The mortality rate of stage IV subjects with intrahepatic metastasis was significantly higher than that of those without (P=0.004). Among the 45 subjects with relapsed hepatoblastoma, the mortality rate was higher in the subjects that abandoned chemotherapy than in patients who continued regular chemotherapy. In total, 27 of 45 subjects with relapsed hepatoblastoma succumbed to the disease; 20 of them abandoned chemotherapy treatment; and the remaining 7 patients underwent regular chemotherapy and succumbed to the disease by the end of follow-up. The present study indicates that the increased mortality rate was associated with postoperative residual-induced intrahepatic metastasis and relapsed hepatoblastoma; and that regular chemotherapy is necessary for patient to achieve complete or partial remission following surgical operation.
authors.affiliation: Department of Pediatrics, Beijing Tongren Hospital, Capital Medical University, Beijing 100176, P.R. China; Department of Pediatrics, People's Liberation Army General Hospital, Beijing 100853, P.R. China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Pediatrics, Beijing Tongren Hospital, Capital Medical University, Beijing 100176, P.R. China.
authors.forename: Weiling
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Department of Pediatrics, People's Liberation Army General Hospital, Beijing 100853, P.R. China.
authors.forename: Suoqin
authors.initials: S
authors.lastname: Tang
authors.affiliation: Department of Pediatrics, Beijing Tongren Hospital, Capital Medical University, Beijing 100176, P.R. China.
authors.forename: Liping
authors.initials: L
authors.lastname: Chen
authors.affiliation: Department of Pediatrics, Beijing Tongren Hospital, Capital Medical University, Beijing 100176, P.R. China.
authors.forename: You
authors.initials: Y
authors.lastname: Yi
authors.affiliation: Department of Pediatrics, Beijing Tongren Hospital, Capital Medical University, Beijing 100176, P.R. China.
authors.forename: Pinwei
authors.initials: P
authors.lastname: Zhang
authors.affiliation: Department of Pediatrics, Beijing Tongren Hospital, Capital Medical University, Beijing 100176, P.R. China.
authors.forename: Aiping
authors.initials: A
authors.lastname: Liu
authors.affiliation: Department of Pediatrics, Beijing Tongren Hospital, Capital Medical University, Beijing 100176, P.R. China.
authors.forename: Tian
authors.initials: T
authors.lastname: Zhi
authors.affiliation: Department of Pediatrics, Beijing Tongren Hospital, Capital Medical University, Beijing 100176, P.R. China.
authors.forename: Dongsheng
authors.initials: D
authors.lastname: Huang
keywords: chemotherapy; pediatric hapatoblastoma; prognosis; surgical operation; survival rate