title: Nucleotides and nucleoside signaling in the regulation of the epithelium to mesenchymal transition (EMT).
abstract: The epithelium-mesenchymal transition (EMT) is an important process of cell plasticity, consisting in the loss of epithelial identity and the gain of mesenchymal characteristics through the coordinated activity of a highly regulated informational program. Although it was originally described in the embryonic development, an important body of information supports its role in pathology, mainly in cancerous and fibrotic processes. The purinergic system of inter-cellular communication, mainly based in ATP and adenosine acting throughout their specific receptors, has emerged as a potent regulator of the EMT in several pathological entities. In this context, cellular signaling associated to purines is opening the understanding of a new element in the complex regulatory network of this phenotypical differentiation process. In this review, we have summarized recent information about the role of ATP and adenosine in EMT, as a growing field with high therapeutic potential.
authors.affiliation: Departamento de Neurobiología Celular y Molecular. Instituto de Neurobiología, Universidad Nacional Autónoma de México, Boulevard Juriquilla, 3001, CP 76230, Juriquilla Querétaro, Mexico.
authors.forename: A S
authors.initials: AS
authors.lastname: Martínez-Ramírez
authors.affiliation: Departamento de Neurobiología Celular y Molecular. Instituto de Neurobiología, Universidad Nacional Autónoma de México, Boulevard Juriquilla, 3001, CP 76230, Juriquilla Querétaro, Mexico.
authors.forename: M
authors.initials: M
authors.lastname: Díaz-Muñoz
authors.affiliation: Departamento de Biología Celular y del Desarrollo. Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, 04510, México, D.F., Mexico.
authors.forename: A
authors.initials: A
authors.lastname: Butanda-Ochoa
authors.affiliation: Departamento de Neurobiología Celular y Molecular. Instituto de Neurobiología, Universidad Nacional Autónoma de México, Boulevard Juriquilla, 3001, CP 76230, Juriquilla Querétaro, Mexico. fvazquez@comunidad.unam.mx.
authors.forename: F G
authors.initials: FG
authors.lastname: Vázquez-Cuevas
mesh_terms: D000818:Animals; D002465:Cell Movement / Q000502:physiology; D058750:Epithelial-Mesenchymal Transition / Q000502:physiology*; D009705:Nucleosides / Q000378:metabolism*; D009711:Nucleotides / Q000378:metabolism*; D011983:Receptors, Purinergic / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D009705:Nucleosides; D009711:Nucleotides; D011983:Receptors, Purinergic
keywords: Cell migration; EMT; P1 receptors; P2 receptors; Purinergic signaling