title: Down-Regulation of LncRNA DGCR5 Correlates with Poor Prognosis in Hepatocellular Carcinoma.
abstract: OBJECTIVE
  Long non-coding RNAs (lncRNAs) have been reported to play pivotal roles in multiple tumors and can act as tumor biomarkers. In this study, we explored the association of the expression of an lncRNA, DGCR5 with clinicopathological features and prognosis in HCC.
  
  
  METHODS
  Expression levels of DGCR5 were detected by quantitative real-time PCR (qRT-PCR) and the clinical data was obtained, including basic information, data of clinicopathology and cancer specific survival rate. Receiver operating characteristic (ROC) curve, Kaplan-Meier methods and multivariable Cox regression models were used to analyze predictive efficiency, long-term survival outcomes and risk factors.
  
  
  RESULTS
  DGCR5 was found down-regulated in HCC tissues (P<0.001) and serum (P = 0.0035) and low expression of DGCR5 was correlated with a poor cancer specific survival (CSS) (P = 0.0019), as the overall 5-year CSS rates were 10.3% (low expression group) and 36.6% (high expression group), respectively. A stratified analysis demonstrated that low DGCR5 expression was an independent negative prognostic factor for HCC. In addition, the area under the ROC curve was 0.782 with a sensitivity of 0.633 and a specificity of 0.833.
  
  
  CONCLUSIONS
  Our results suggest that DGCR5 may be a participator in HCC and can serve as potential biomarker for the diagnosis and prognosis in HCC.
authors.affiliation: Key Laboratory on Living Donor Liver Transplantation, Ministry of Health, Department of Liver surgery, Collaborative Innovation Center For Cancer Personalized Medicine, First Affiliated Hospital of Nanjing Medical University, Nanjing, P.R. China.
authors.forename: Ruyi
authors.initials: R
authors.lastname: Huang
authors.forename: Xiaochen
authors.initials: X
authors.lastname: Wang
authors.forename: Wenjie
authors.initials: W
authors.lastname: Zhang
authors.forename: Guangyan
authors.initials: G
authors.lastname: Zhangyuan
authors.forename: Kangpeng
authors.initials: K
authors.lastname: Jin
authors.forename: Weiwei
authors.initials: W
authors.lastname: Yu
authors.forename: Yu
authors.initials: Y
authors.lastname: Xie
authors.forename: Xiaoliang
authors.initials: X
authors.lastname: Xu
authors.forename: Hai
authors.initials: H
authors.lastname: Wang
authors.forename: Beicheng
authors.initials: B
authors.lastname: Sun
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism; D006528:Carcinoma, Hepatocellular / Q000097:blood / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D015536:Down-Regulation / Q000235:genetics*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008113:Liver Neoplasms / Q000097:blood / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D020871:RNA Stability / Q000235:genetics; D062085:RNA, Long Noncoding / Q000235:genetics* / Q000378:metabolism; D016019:Survival Analysis
chemical_list: D014408:Biomarkers, Tumor; D062085:RNA, Long Noncoding; C000614089:long noncoding RNA DGCR5, human