title: Effect of a Novel NMDA Receptor Modulator, Rapastinel (Formerly GLYX-13), in OCD: Proof of Concept.
authors.affiliation: From the Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, Calif.; the Veterans Affairs Palo Alto Health Care System, Palo Alto, Calif.; the Department of Psychology, The Hebrew University of Jerusalem, Israel; the Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York; the New York State Psychiatric Institute, New York; Aptinyx, Evanston, Ill.; and the Falk Center for Molecular Therapeutics, Department of Biomedical Engineering, McCormick School of Engineering and Applied Sciences, Northwestern University, Evanston, Ill.
authors.forename: Carolyn I
authors.initials: CI
authors.lastname: Rodriguez
authors.affiliation: From the Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, Calif.; the Veterans Affairs Palo Alto Health Care System, Palo Alto, Calif.; the Department of Psychology, The Hebrew University of Jerusalem, Israel; the Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York; the New York State Psychiatric Institute, New York; Aptinyx, Evanston, Ill.; and the Falk Center for Molecular Therapeutics, Department of Biomedical Engineering, McCormick School of Engineering and Applied Sciences, Northwestern University, Evanston, Ill.
authors.forename: Jordana
authors.initials: J
authors.lastname: Zwerling
authors.affiliation: From the Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, Calif.; the Veterans Affairs Palo Alto Health Care System, Palo Alto, Calif.; the Department of Psychology, The Hebrew University of Jerusalem, Israel; the Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York; the New York State Psychiatric Institute, New York; Aptinyx, Evanston, Ill.; and the Falk Center for Molecular Therapeutics, Department of Biomedical Engineering, McCormick School of Engineering and Applied Sciences, Northwestern University, Evanston, Ill.
authors.forename: Eyal
authors.initials: E
authors.lastname: Kalanthroff
authors.affiliation: From the Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, Calif.; the Veterans Affairs Palo Alto Health Care System, Palo Alto, Calif.; the Department of Psychology, The Hebrew University of Jerusalem, Israel; the Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York; the New York State Psychiatric Institute, New York; Aptinyx, Evanston, Ill.; and the Falk Center for Molecular Therapeutics, Department of Biomedical Engineering, McCormick School of Engineering and Applied Sciences, Northwestern University, Evanston, Ill.
authors.forename: Hanyang
authors.initials: H
authors.lastname: Shen
authors.affiliation: From the Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, Calif.; the Veterans Affairs Palo Alto Health Care System, Palo Alto, Calif.; the Department of Psychology, The Hebrew University of Jerusalem, Israel; the Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York; the New York State Psychiatric Institute, New York; Aptinyx, Evanston, Ill.; and the Falk Center for Molecular Therapeutics, Department of Biomedical Engineering, McCormick School of Engineering and Applied Sciences, Northwestern University, Evanston, Ill.
authors.forename: Maria
authors.initials: M
authors.lastname: Filippou
authors.affiliation: From the Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, Calif.; the Veterans Affairs Palo Alto Health Care System, Palo Alto, Calif.; the Department of Psychology, The Hebrew University of Jerusalem, Israel; the Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York; the New York State Psychiatric Institute, New York; Aptinyx, Evanston, Ill.; and the Falk Center for Molecular Therapeutics, Department of Biomedical Engineering, McCormick School of Engineering and Applied Sciences, Northwestern University, Evanston, Ill.
authors.forename: Booil
authors.initials: B
authors.lastname: Jo
authors.affiliation: From the Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, Calif.; the Veterans Affairs Palo Alto Health Care System, Palo Alto, Calif.; the Department of Psychology, The Hebrew University of Jerusalem, Israel; the Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York; the New York State Psychiatric Institute, New York; Aptinyx, Evanston, Ill.; and the Falk Center for Molecular Therapeutics, Department of Biomedical Engineering, McCormick School of Engineering and Applied Sciences, Northwestern University, Evanston, Ill.
authors.forename: Helen Blair
authors.initials: HB
authors.lastname: Simpson
authors.affiliation: From the Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, Calif.; the Veterans Affairs Palo Alto Health Care System, Palo Alto, Calif.; the Department of Psychology, The Hebrew University of Jerusalem, Israel; the Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York; the New York State Psychiatric Institute, New York; Aptinyx, Evanston, Ill.; and the Falk Center for Molecular Therapeutics, Department of Biomedical Engineering, McCormick School of Engineering and Applied Sciences, Northwestern University, Evanston, Ill.
authors.forename: Ronald M
authors.initials: RM
authors.lastname: Burch
authors.affiliation: From the Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, Calif.; the Veterans Affairs Palo Alto Health Care System, Palo Alto, Calif.; the Department of Psychology, The Hebrew University of Jerusalem, Israel; the Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York; the New York State Psychiatric Institute, New York; Aptinyx, Evanston, Ill.; and the Falk Center for Molecular Therapeutics, Department of Biomedical Engineering, McCormick School of Engineering and Applied Sciences, Northwestern University, Evanston, Ill.
authors.forename: Joseph R
authors.initials: JR
authors.lastname: Moskal
mesh_terms: D000293:Adolescent; D000328:Adult; D006801:Humans; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000188:drug therapy* / Q000523:psychology; D009842:Oligopeptides / Q000627:therapeutic use*; D011569:Psychiatric Status Rating Scales; D016194:Receptors, N-Methyl-D-Aspartate / Q000819:agonists*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D009842:Oligopeptides; D016194:Receptors, N-Methyl-D-Aspartate; C507283:GLYX-13 peptide
keywords: AMPA; Clinical Drug Studies; GLYX-13; Ketamine; NMDA; OCD; Obsessive-Compulsive Disorder; Rapastinel