title: Recent progress on magnetic iron oxide nanoparticles: synthesis, surface functional strategies and biomedical applications.
abstract: This review focuses on the recent development and various strategies in the preparation, microstructure, and magnetic properties of bare and surface functionalized iron oxide nanoparticles (IONPs); their corresponding biological application was also discussed. In order to implement the practicalin vivoorin vitroapplications, the IONPs must have combined properties of high magnetic saturation, stability, biocompatibility, and interactive functions at the surface. Moreover, the surface of IONPs could be modified by organic materials or inorganic materials, such as polymers, biomolecules, silica, metals, etc. The new functionalized strategies, problems and major challenges, along with the current directions for the synthesis, surface functionalization and bioapplication of IONPs, are considered. Finally, some future trends and the prospects in these research areas are also discussed.
authors.forename: Wei
authors.initials: W
authors.lastname: Wu
authors.affiliation: Department of Chemical Engineering, Kyung Hee University, Korea.
authors.forename: Zhaohui
authors.initials: Z
authors.lastname: Wu
authors.affiliation: Department of Chemical Engineering, Kyung Hee University, Korea.
authors.forename: Taekyung
authors.initials: T
authors.lastname: Yu
authors.affiliation: Key Laboratory of Artificial Micro- and Nano-structures of Ministry of Education, School of Physics and Technology, Wuhan University, Wuhan 430072, People's Republic of China.
authors.forename: Changzhong
authors.initials: C
authors.lastname: Jiang
authors.affiliation: Department of Chemical Engineering, Kyung Hee University, Korea.
authors.forename: Woo-Sik
authors.initials: WS
authors.lastname: Kim
keywords: biomedical application; magnetic iron oxide nanoparticles; surface functional strategy