title: Advances in Stem Cell Research- A Ray of Hope in Better Diagnosis and Prognosis in Neurodegenerative Diseases.
abstract: Neurodegeneration and neurodegenerative disorders have been a global health issue affecting the aging population worldwide. Recent advances in stem cell biology have changed the current face of neurodegenerative disease modeling, diagnosis, and transplantation therapeutics. Stem cells also serve the purpose of a simplein-vitrotool for screening therapeutic drugs and chemicals. We present the application of stem cells and induced pluripotent stem cells (iPSCs) in the field of neurodegeneration and address the issues of diagnosis, modeling, and therapeutic transplantation strategies for the most prevalent neurodegenerative disorders. We have discussed the progress made in the last decade and have largely focused on the various applications of stem cells in the neurodegenerative research arena.
authors.affiliation: System Toxicology and Health Risk Assessment Group, Council of Scientific and Industrial Research-Indian Institute of Toxicology ResearchLucknow, India; Academy of Scientific and Innovative ResearchLucknow, India.
authors.forename: Shripriya
authors.initials: S
authors.lastname: Singh
authors.affiliation: System Toxicology and Health Risk Assessment Group, Council of Scientific and Industrial Research-Indian Institute of Toxicology Research Lucknow, India.
authors.forename: Akriti
authors.initials: A
authors.lastname: Srivastava
authors.affiliation: System Toxicology and Health Risk Assessment Group, Council of Scientific and Industrial Research-Indian Institute of Toxicology Research Lucknow, India.
authors.forename: Pranay
authors.initials: P
authors.lastname: Srivastava
authors.affiliation: System Toxicology and Health Risk Assessment Group, Council of Scientific and Industrial Research-Indian Institute of Toxicology ResearchLucknow, India; Academy of Scientific and Innovative ResearchLucknow, India.
authors.forename: Yogesh K
authors.initials: YK
authors.lastname: Dhuriya
authors.affiliation: System Toxicology and Health Risk Assessment Group, Council of Scientific and Industrial Research-Indian Institute of Toxicology Research Lucknow, India.
authors.forename: Ankita
authors.initials: A
authors.lastname: Pandey
authors.affiliation: System Toxicology and Health Risk Assessment Group, Council of Scientific and Industrial Research-Indian Institute of Toxicology ResearchLucknow, India; Academy of Scientific and Innovative ResearchLucknow, India.
authors.forename: Dipak
authors.initials: D
authors.lastname: Kumar
authors.affiliation: System Toxicology and Health Risk Assessment Group, Council of Scientific and Industrial Research-Indian Institute of Toxicology ResearchLucknow, India; Academy of Scientific and Innovative ResearchLucknow, India.
authors.forename: Chetan S
authors.initials: CS
authors.lastname: Rajpurohit
keywords: Induced pluripotent stem cells (iPSCs); diagnosis; disease modeling; neurodegenerative disorders; stem cells