title: IL-23R mutation is associated with ulcerative colitis: A systemic review and meta-analysis.
abstract: OBJECTIVE
  Since a genome-wide association study revealed that Interleukin-23 receptor (IL-23R) gene is a candidate gene for Ulcerative Colitis (UC), many studies have investigated the association between the IL-23R polymorphisms and UC. However, the results were controversial. The aim of the study was to determine whether the IL-23R polymorphisms confer susceptibility to UC.
  
  
  METHODS
  A systematic literature search was carried out to identify all potentially relevant studies. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were used to estimate the strength of association.
  
  
  RESULTS
  A total of 33 studies in 32 articles, including 10,527 UC cases and 15,142 healthy controls, were finally involved in the meta-analysis. Overall, a significant association was found between all UC cases and the rs11209026A allele (OR = 0.665, 95% CI = 0.604~0.733, P < 0.001). Similarly, meta-analyses of the rs7517847, rs1004819, rs10889677, rs2201841, rs11209032, rs1495965, rs1343151 and rs11465804 polymorphisms also indicated significant association with all UC (all P < 0.05). Stratification by ethnicity revealed that the rs11209026, rs7517847, rs10889677, rs2201841 andrs11465804 polymorphisms were associated with UC in the Caucasian group, but not in Asians, while the rs1004819 and rs11209032 polymorphisms were found to be related to UC for both Caucasian and Asian groups. However, subgroup analysis failed to unveil any association between the rs1495965 and rs1343151 polymorphisms and UC in Caucasians or Asians.
  
  
  CONCLUSIONS
  The meta-analysis suggests significant association between IL-23R polymorphisms and UC, especially in Caucasians.
authors.affiliation: Department of Science and Education, The Second People's Hospital of Wuhu, Wuhu, Anhui 241000, China.
authors.forename: Ling-Long
authors.initials: LL
authors.lastname: Peng
authors.affiliation: Department of Environmental Health, Suzhou Municipal Center for Disease Prevention and Control, Suzhou, Jiangsu 215004, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Science and Education, The Second People's Hospital of Wuhu, Wuhu, Anhui 241000, China.
authors.forename: Feng-Ling
authors.initials: FL
authors.lastname: Zhu
authors.affiliation: Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
authors.forename: Wang-Dong
authors.initials: WD
authors.lastname: Xu
authors.affiliation: Department of Science and Education, The Second People's Hospital of Wuhu, Wuhu, Anhui 241000, China.
authors.forename: Xue-Lei
authors.initials: XL
authors.lastname: Ji
authors.affiliation: The Teaching Centre for Preventive Medicine, School of Public Health, Anhui Medical University, Hefei, Anhui 230032, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Ni
mesh_terms: D044466:Asian People / Q000235:genetics; D003093:Colitis, Ulcerative / Q000208:ethnology / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D018123:Receptors, Interleukin / Q000235:genetics*; D044465:White People / Q000235:genetics
chemical_list: C515500:IL23R protein, human; D018123:Receptors, Interleukin
keywords: IL-23R; meta-analysis; polymorphism; susceptibility; ulcerative colitis