title: Diagnosis and Management of Microscopic Colitis.
abstract: Microscopic colitis (MC) is a relatively common cause of chronic watery diarrhea, especially in older persons. Associated symptoms, including abdominal pain and arthralgias, are common. The diagnosis is based upon characteristic histological findings in the presence of diarrhea. The two types of MC, collagenous and lymphocytic colitis, share similar clinical features, with the main difference being the presence or absence of a thickened subepithelial collagen band. There are several treatment options for patients with MC, although only budesonide has been well studied in multiple controlled clinical trials. This review will describe the clinical features, epidemiology, pathophysiology, diagnostic criteria, and treatment of patients with MC.
authors.affiliation: Inflammatory Bowel Disease Clinic, Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
authors.forename: Darrell S
authors.initials: DS
authors.lastname: Pardi
mesh_terms: D000837:Anion Exchange Resins / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D000930:Antidiarrheals / Q000627:therapeutic use; D015551:Autoimmunity / Q000276:immunology; D001647:Bile Acids and Salts / Q000378:metabolism; D019819:Budesonide / Q000627:therapeutic use; D002792:Cholestyramine Resin / Q000627:therapeutic use; D046729:Colitis, Collagenous / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D046730:Colitis, Lymphocytic / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D046728:Colitis, Microscopic / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D003094:Collagen / Q000378:metabolism; D003106:Colon / Q000473:pathology; D020022:Genetic Predisposition to Disease; D005938:Glucocorticoids / Q000627:therapeutic use; D006680:HLA Antigens / Q000235:genetics / Q000276:immunology; D006801:Humans; D019804:Mesalamine / Q000627:therapeutic use
chemical_list: D000837:Anion Exchange Resins; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000930:Antidiarrheals; D001647:Bile Acids and Salts; D005938:Glucocorticoids; D006680:HLA Antigens; D002792:Cholestyramine Resin; D019804:Mesalamine; D019819:Budesonide; D003094:Collagen