title: The slippery difficulty of ever containing drug resistance with current practices.
abstract: It has previously been shown that the rate of drug resistance emergence in medicine is exponential, while we have been producing drugs at a much lower rate. Our ability to successfully contain resistance at any one time is function of how many drugs we have at our disposal to counter new resistances from pathogens. Here, we assess our level of preparedness through a mathematical comparison of the drug manufacture rate by the pharmaceutical industry with the resistance emergence rate in pathogens. To that effect, changes in the rates of growth of the drugs production and resistance emergence processes are computed over multiple time segments and compared. It is found that new resistance emergence rate in infectious diseases medicine remains mathematically and permanently ahead of the drugs production rate by the pharmaceutical industry. Consequently, we are not in a position to ever contain current or future strengths of resistance from pathogens. A review of current practices is called for.
authors.affiliation: Department of Applied Research, Applied-Research Center for True Development, 4016 rue Prefontaine, Montréal, Québec, H1W 0A3, Canada. fullybright@gmail.com.
authors.forename: R
authors.initials: R
authors.lastname: Fullybright
mesh_terms: D000890:Anti-Infective Agents / Q000302:isolation & purification* / Q000494:pharmacology* / Q000627:therapeutic use; D055808:Drug Discovery / Q000639:trends*; D004352:Drug Resistance, Microbial; D006801:Humans; D008962:Models, Theoretical
chemical_list: D000890:Anti-Infective Agents
keywords: Antibiotic; Disease; Drug; Infectious; Pathogen; Pharmaceutical; Rate; Resistance