title: The origin and diversification of the developmental mechanisms that pattern the vertebrate head skeleton.
abstract: The apparent evolvability of the vertebrate head skeleton has allowed a diverse array of shapes, sizes, and compositions of the head in order to better adapt species to their environments. This encompasses feeding, breathing, sensing, and communicating: the head skeleton somehow participated in the evolution of all these critical processes for the last 500 million years. Through evolution, present head diversity was made possible via developmental modifications to the first head skeletal genetic program. Understanding the development of the vertebrate common ancestor's head skeleton is thus an important step in identifying how different lineages have respectively achieved their many innovations in the head. To this end, cyclostomes (jawless vertebrates) are extremely useful, having diverged from jawed vertebrates approximately 400 million years ago, at the deepest node within living vertebrates. From this ancestral vantage point (that is, the node connecting cyclostomes and gnathostomes) we can best identify the earliest major differences in development between vertebrate classes, and start to address how these might translate onto morphology. In this review we survey what is currently known about the cell biology and gene expression during head development in modern vertebrates, allowing us to better characterize the developmental genetics driving head skeleton formation in the most recent common ancestor of all living vertebrates. By pairing this vertebrate composite with information from fossil chordates, we can also deduce how gene regulatory modules might have been arranged in the ancestral vertebrate head. Together, we can immediately begin to understand which aspects of head skeletal development are the most conserved, and which are divergent, informing us as to when the first differences appear during development, and thus which pathways or cell types might be involved in generating lineage specific shape and structure.
authors.affiliation: Department of Ecology and Evolutionary Biology, University of Colorado, Boulder, CO 80309, USA. Electronic address: square@colorado.edu.
authors.forename: Tyler
authors.initials: T
authors.lastname: Square
authors.affiliation: Department of Ecology and Evolutionary Biology, University of Colorado, Boulder, CO 80309, USA; Department of Zoology, Comenius University in Bratislava, Bratislava 84215, Slovakia; Department of Zoology, Charles University in Prague, 128 44 Prague, Czech Republic.
authors.forename: David
authors.initials: D
authors.lastname: Jandzik
authors.affiliation: Department of Ecology and Evolutionary Biology, University of Colorado, Boulder, CO 80309, USA; Department of Zoology, Charles University in Prague, 128 44 Prague, Czech Republic.
authors.forename: Marek
authors.initials: M
authors.lastname: Romášek
authors.affiliation: Department of Zoology, Charles University in Prague, 128 44 Prague, Czech Republic.
authors.forename: Robert
authors.initials: R
authors.lastname: Cerny
authors.affiliation: Department of Ecology and Evolutionary Biology, University of Colorado, Boulder, CO 80309, USA. Electronic address: daniel.medeiros@colorado.edu.
authors.forename: Daniel Meulemans
authors.initials: DM
authors.lastname: Medeiros
mesh_terms: D000818:Animals; D005075:Biological Evolution; D005580:Fossils; D014644:Genetic Variation; D006257:Head / Q000254:growth & development; D012886:Skull / Q000254:growth & development*; D014714:Vertebrates / Q000235:genetics / Q000254:growth & development*