title: An emerging role for IQGAP1 in tight junction control.
abstract: IQGAP1 is a scaffold protein involved in the assembly of adherens junctions. Our work has recently revealed a novel role for IQGAP1 in the regulation of tight junctions (TJ) through differential recruitment of claudins to the nascent TJ. Here, we discuss the potential mechanisms of this regulation, including IQGAP1 effects on CDC42, and IQGAP1 interactions with sorting/trafficking molecules (e.g. Exo70). Given the many roles of IQGAP1 and the large number of interacting partners, we focus our discussion of these functions in the context of junction formation, trafficking, growth factor signaling and cancer. We also propose a potential role for IQGAP1 in regulating epithelial integrity and compartmentalized signaling in epithelia.
authors.affiliation: a Division of Cancer Therapeutics, The Institute of Cancer Research , London , UK.
authors.forename: Barbara E
authors.identifier: 0000-0002-7045-9496
authors.initials: BE
authors.lastname: Tanos
authors.affiliation: b Department of Anatomy and Cell Biology , The University of Iowa , Iowa City , IA , USA.
authors.forename: Charles
authors.identifier: 0000-0001-6149-628X
authors.initials: C
authors.lastname: Yeaman
authors.affiliation: c Department of Ophthalmology , Margaret Dyson Vision Research Institute, Weill Cornell Medical College , New York , NY , USA.|d Department of Cell and Developmental Biology , Weill Cornell Medical College , New York , NY , USA.
authors.forename: Enrique
authors.identifier: 0000-0003-2033-6233
authors.initials: E
authors.lastname: Rodriguez-Boulan
mesh_terms: D000818:Animals; D002448:Cell Adhesion; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology; D015398:Signal Transduction; D019108:Tight Junctions / Q000378:metabolism*; D020703:ras GTPase-Activating Proteins / Q000378:metabolism*
chemical_list: C101203:IQ motif containing GTPase activating protein 1; D036341:Intercellular Signaling Peptides and Proteins; D020703:ras GTPase-Activating Proteins
keywords: IQGAP1; cdc42; claudins; exocyst; tight junctions