title: A genomic study on distribution ofhuman leukocyte antigen(HLA)-AandHLA-Balleles in Lak population of Iran.
abstract: Anthropological studies based on the highly polymorphic gene,human leukocyte antigen(HLA), provide useful information for bone marrow donor registry, forensic medicine, disease association studies, as well as infertility treatment, designing peptide vaccines against tumors, and infectious or autoimmune diseases. The aim of this study was to determineHLA-AandHLA-Ballele frequencies in 100 unrelated Lak/lᴂk/individuals from Lorestan province of Iran. Finally, we compared the results with that previously described in Iranian population. Commercial HLA-Type kits from BAG (Lich, Germany) company were used for determination of theHLA-AandHLA-Ballele frequencies in genomic DNA, based on polymerase chain reaction with sequence specific primer (PCR-SSP) assay. The differences between the populations in distribution ofHLA-AandHLA-Balleles were estimated by chi-squared test with Yate's correction. The most frequentHLA-Aalleles were *24 (20%), *02 (18%), *03 (12%) and *11 (10%), and the most frequentHLA-Balleles were *35 (24%), *51 (16%), *18 (6%) and *38 (6%) in Lak population.HLA-A*66 (1%), *74(1%) andHLA-B*48 (1%), *55(1%) were the least observed frequencies in Lak population. Our results based onHLA-AandHLA-Ballele frequencies showed that Lak population possesses the previously reported general features of Iranians but still with unique.
authors.affiliation: Department of immunology, Lorestan University of Medical Sciences, Khorramabad, Iran.
authors.forename: Farhad
authors.initials: F
authors.lastname: Shahsavar
authors.affiliation: Department of immunology, Lorestan University of Medical Sciences, Khorramabad, Iran.
authors.forename: Ali-Mohammad
authors.initials: AM
authors.lastname: Varzi
authors.affiliation: Research Office for the History of Persian Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran; Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran.
authors.forename: Seyyed Amir Yasin
authors.initials: SA
authors.lastname: Ahmadi
keywords: Anthropology; HLA class I; Immunology; Iran; Lak population