title: What We Know and Do Not Know About Actin.
abstract: Seven decades of research have revealed much about actin structure, assembly, regulatory proteins, and cellular functions. However, some key information is still missing, so we do not understand the mechanisms of most processes that depend on actin. This chapter summarizes our current knowledge and explains some examples of work that will be required to fill these gaps and arrive at a mechanistic understanding of actin biology.
authors.affiliation: Department of Molecular Cellular and Developmental Biology, Yale University, 208103, New Haven, CT, 06520-8103, USA. thomas.pollard@yale.edu.|Department of Molecular Biophysics and Biochemistry, Yale University, 208103, New Haven, CT, 06520-8103, USA. thomas.pollard@yale.edu.|Department of Cell Biology, Yale University, 208103, New Haven, CT, 06520-8103, USA. thomas.pollard@yale.edu.
authors.forename: Thomas D
authors.initials: TD
authors.lastname: Pollard
mesh_terms: D008841:Actin Cytoskeleton / Q000737:chemistry; D051376:Actin-Related Protein 2-3 Complex / Q000502:physiology; D000199:Actins / Q000737:chemistry / Q000502:physiology*; D000818:Animals; D002465:Cell Movement; D006801:Humans; D058105:Polymerization
chemical_list: D051376:Actin-Related Protein 2-3 Complex; D000199:Actins
keywords: Actin; Arp2/3 complex; Capping protein; Cofilin; Profilin