title: Increased expression of microRNA-148a in osteosarcoma promotes cancer cell growth by targeting PTEN.
abstract: Osteosarcoma is the most common type of primary malignant bone tumor, and deregulated microRNAs (miRNAs or miRs) in osteosarcoma have attracted great attention. In the present study, through miRNA microarray analysis, it was identified that miR-148a expression was significantly increased in osteosarcoma tissues. Increased miR-148a expression was significantly correlated with tumor progression and prognosis. Furthermore, increased miR-148a expression could promote osteosarcoma growthin vitroandin vivo, and the tumor-promoting effect was due to enhanced activation of the phosphoinositide 3-kinase signaling pathway caused by miR-148a-mediated inhibition of phosphatase and tensin homolog expression. Together, the present results suggest a role for miR-148a in osteosarcoma development and its potential use in prognosis prediction and cancer therapy.
authors.affiliation: Department of Orthopedics, Changhai Hospital, The Second Military Medical University, Shanghai 200433, P.R. China.
authors.forename: Hao
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Orthopedics, General Hospital of Beijing Military Region, Beijing 100700, P.R. China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Orthopedics, Changzheng Hospital, The Second Military Medical University, Shanghai 200003, P.R. China.
authors.forename: Tianming
authors.initials: T
authors.lastname: Xu
authors.affiliation: Department of Orthopedics, Changhai Hospital, The Second Military Medical University, Shanghai 200433, P.R. China.
authors.forename: Chen
authors.initials: C
authors.lastname: Li
authors.affiliation: Department of Orthopedics, Changhai Hospital, The Second Military Medical University, Shanghai 200433, P.R. China.
authors.forename: Jiang
authors.initials: J
authors.lastname: Wu
authors.affiliation: Department of Orthopedics, Changhai Hospital, The Second Military Medical University, Shanghai 200433, P.R. China.
authors.forename: Qianyun
authors.initials: Q
authors.lastname: He
authors.affiliation: Department of Orthopedics, Changhai Hospital, The Second Military Medical University, Shanghai 200433, P.R. China.
authors.forename: Guangchao
authors.initials: G
authors.lastname: Wang
authors.affiliation: Department of Orthopedics, Changhai Hospital, The Second Military Medical University, Shanghai 200433, P.R. China.
authors.forename: Chen
authors.initials: C
authors.lastname: Ding
authors.affiliation: Department of Orthopedics, Changhai Hospital, The Second Military Medical University, Shanghai 200433, P.R. China.
authors.forename: Kang
authors.initials: K
authors.lastname: Liu
authors.affiliation: Department of Orthopedics, Changhai Hospital, The Second Military Medical University, Shanghai 200433, P.R. China.
authors.forename: Hao
authors.initials: H
authors.lastname: Tang
authors.affiliation: Department of Orthopedics, Changhai Hospital, The Second Military Medical University, Shanghai 200433, P.R. China.
authors.forename: Fang
authors.initials: F
authors.lastname: Ji
keywords: PI3K; PTEN; miR-148a; microRNA; osteosarcoma; proliferation