title: The trajectory of negative mood and depressive symptoms over two decades.
abstract: OBJECTIVE
  Research aimed at understanding the temporal characteristics of depressive symptoms and negative mood in an older female population is lacking, despite the relationship between the two factors being well established. The aim of this study was to examine the characteristics of negative mood scores and depressive symptom scores in a longitudinal sample of women transitioning from mid-life to late life.
  
  
  METHODS
  This study was a longitudinal assessment of variables drawn from an epidemiological prospective study of women's healthy ageing. Scores were analysed using General Linear Mixed Models.
  
  
  METHODS
  Negative mood scores derived from the Affectometer 2 were assessed at 11 time points spanning 20 years. Depressive symptom scores were assessed using the Centre for Epidemiological Studies Depression Scale (CESD), administered in 2002, 2004 and 2012.
  
  
  RESULTS
  Mean negative mood scores reduced significantly between 1992 and 2012, as did mean CESD scores between 2002 and 2012. Mean negative mood scores reduced by 0.007 for each year of increasing age. For depressive symptoms, a reduction in mean score of 0.15 was found for each year of increase in age.
  
  
  CONCLUSIONS
  Depressive symptom scores and negative mood scores decreased significantly over time.
authors.affiliation: Department of Psychiatry, University of Melbourne, Victoria, Australia.
authors.forename: Katherine E
authors.initials: KE
authors.lastname: Campbell
authors.affiliation: Department of Psychiatry, University of Melbourne, Victoria, Australia.
authors.forename: Lorraine
authors.initials: L
authors.lastname: Dennerstein
authors.affiliation: Melbourne EpiCentre, Department of Medicine, University of Melbourne, Victoria, Australia.
authors.forename: Mark
authors.initials: M
authors.lastname: Tacey
authors.affiliation: Department of Medicine, University of Melbourne, Victoria, Australia. Electronic address: cszoeke@unimelb.edu.au.
authors.forename: Cassandra E
authors.initials: CE
authors.lastname: Szoeke
mesh_terms: D000339:Affect / Q000502:physiology*; D000375:Aging / Q000523:psychology; D003863:Depression / Q000175:diagnosis* / Q000523:psychology; D018450:Disease Progression; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008875:Middle Aged; D011446:Prospective Studies
keywords: Affectometer-2; CESD; Depressive symptoms; Negative mood