title: Possible approaches to CYP2C9-guided prescription of sulfonylureas in Russia.
abstract: OBJECTIVE
  To evaluate a possible role of CYP2C9 genotyping for sulfonylureas (SUs) prescription in Russia.
  
  
  METHODS
  We have collected the current data on correlation between SUs pharmacodynamics and CYP2C9 polymorphisms. We have evaluated the frequency of CYP2C9 polymorphisms in Russia by reviewing the literature published from 2004 to 2015 on Russian CYP2C9.
  
  
  RESULTS
  The genotype *1/*1, which confers risk for treatment failure, has a higher frequency (81.92%) in the non-Caucasians than that (64.92%) in the Caucasians. The Caucasians have a frequency (3.58%) of the poor metabolizers (*2/*2, *2/*3 and *3/*3) eight-times higher than that (0.44%) in the non-Caucasians, predisposing an increased risk of hypoglycemia.
  
  
  CONCLUSIONS
  Considering the received data and the existed knowledge on CYP2C9 influence on SUs pharmacokinetics and pharmacodynamics, we propose a possible approach to CYP2C9-guided SUs prescription for Russians.
authors.affiliation: Department of Endocrinology, Pavlov First St. Petersburg State Medical University, St. Petersburg, Russia.
authors.forename: Anna
authors.initials: A
authors.lastname: Mosikian
authors.affiliation: Department of Endocrinology, Pavlov First St. Petersburg State Medical University, St. Petersburg, Russia.
authors.forename: Antonina
authors.initials: A
authors.lastname: Dolgorukova
authors.affiliation: Department of Endocrinology, Pavlov First St. Petersburg State Medical University, St. Petersburg, Russia.
authors.forename: Alsu
authors.initials: A
authors.lastname: Zalevskaya
mesh_terms: D065729:Cytochrome P-450 CYP2C9 / Q000235:genetics*; D005838:Genotype; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D011110:Polymorphism, Genetic; D012426:Russia; D013453:Sulfonylurea Compounds / Q000627:therapeutic use*
chemical_list: D007004:Hypoglycemic Agents; D013453:Sulfonylurea Compounds; D065729:Cytochrome P-450 CYP2C9
keywords: CYP2C9; sulfonylureas; worldwide Russians