title: Lipid Accumulation Product (LAP) as an Index of Metabolic and Hormonal Disorders in Aging Men.
abstract: Lipid accumulation product (LAP) is an index used for evaluating lipid overaccumulation in adults. Our study aimed at assessing associations between LAP and metabolic syndrome (MetS) and its components, age-related testosterone deficiency syndrome (TDS), low-density cholesterol (LDL), as well as HOMA-IR (insulin resistance ratio), insulin level in non-diabetics and total testosterone (TT), estradiol E2, dehydroepiandrosterone sulphate (DHEAs) and sex hormone-binding globulin (SHBG) in aging men.313 men aged 50-75 were surveyed with regard to the prevalence of diabetes (T2DM) and hypertension (HT). Anthropometric measurements, including waist circumference and arterial pressure, were performed. We also determined the levels of fasting plasma glucose (FPG), total cholesterol (TC), high-density cholesterol (HDL), low-density cholesterol (LDL), triglyceride (TG), insulin, TT, SHBG, DHEAs, and E2.Patients with diagnosed MetS, T2DM, HT, obesity, overweight and TDS had a significantly higher LAP compared to those without these conditions. LAP was significantly positively correlated with serum TC, FPG, insulin, DHEAs, as well as APB-systolic concentration, and negatively correlated with HDL, TT, and SHBG.LAP may then be used as a simple and inexpensive biomarker of metabolic disorders, and in risk assessment related to testosterone deficiency in aging men.
authors.affiliation: Department of Medical Rehabilitation, Pomeranian Medical University in Szczecin, Szczecin, Poland.
authors.forename: I
authors.initials: I
authors.lastname: Rotter
authors.affiliation: Department of Histology and Developmental Biology, Pomeranian Medical University in Szczecin, Szczecin, Poland.
authors.forename: A
authors.initials: A
authors.lastname: Rył
authors.affiliation: Department of Medical Rehabilitation, Pomeranian Medical University in Szczecin, Szczecin, Poland.
authors.forename: A
authors.initials: A
authors.lastname: Szylińska
authors.affiliation: Department of Medical Rehabilitation, Pomeranian Medical University in Szczecin, Szczecin, Poland.
authors.forename: W
authors.initials: W
authors.lastname: Pawlukowska
authors.affiliation: Department of Physical Medicine and Functional Diagnostics, Pomeranian Medical University in Szczecin, Pomeranian Medical University in Szczecin, Szczecin, Poland.
authors.forename: A
authors.initials: A
authors.lastname: Lubkowska
authors.affiliation: Department of Histology and Developmental Biology, Pomeranian Medical University in Szczecin, Szczecin, Poland.
authors.forename: M
authors.initials: M
authors.lastname: Laszczyńska
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000097:blood*; D001786:Blood Glucose / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D006801:Humans; D006973:Hypertension / Q000097:blood*; D064237:Lipid Accumulation Product; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D013739:Testosterone / Q000097:blood*; D055105:Waist Circumference
chemical_list: D001786:Blood Glucose; D008055:Lipids; D013739:Testosterone