title: Influence of a Moderate-Intensity Exercise Program on Early NK Cell Immune Recovery in Pediatric Patients After Reduced-Intensity Hematopoietic Stem Cell Transplantation.
abstract: After allogeneic hematopoietic stem cell transplantation (HSCT), NK cell reconstitution, which is crucial for positive outcomes, is dominated by the CD56brightsubset with low NK cell cytotoxicity (NKCC) activity. Moderate exercise has been described as a potent NK cell stimulus in adults with cancer.
  
  
  
  To determine the effects of a moderate-intensity exercise program on NK cell recovery early after HSCT and the feasibility of this intervention.
  
  
  
  Six children undergoing allogeneic HSCT were randomized to an exercise program (EP) or control (CT) group. The EP group performed a 10-week training combining in-hospital and home-based EP.
  
  
  
  We observed a significant increase in the posttraining/pretraining ratio of the CD56dimsubset (EP = 1.27 ± 0.07; CT = 0.99 ± 0.08; P < .005) of the EP group. The ratio of NKCC was 8 times greater in the EP group.
  
  
  
  Data suggest that a moderate-intensity EP program performed early after HSCT is feasible and might redistribute the CD56dim/CD56brighNK cell subset, improving NKCC. The results are still preliminary and must be interpreted with caution.
authors.affiliation: 1 Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada.
authors.forename: Carolina
authors.initials: C
authors.lastname: Chamorro-Viña
authors.affiliation: 2 Innate Immune Research Group, IdiPAZ, Madrid, Spain.
authors.forename: Jaime
authors.initials: J
authors.lastname: Valentín
authors.affiliation: 3 Cancer Research National Centre, Madrid, Spain.
authors.forename: Lucía
authors.initials: L
authors.lastname: Fernández
authors.affiliation: 4 Hospital Universitario Niño Jesús, Madrid, Spain.
authors.forename: Marta
authors.initials: M
authors.lastname: González-Vicent
authors.affiliation: 5 Universidad Europea de Madrid, Madrid, Spain.
authors.forename: Margarita
authors.initials: M
authors.lastname: Pérez-Ruiz
authors.affiliation: 5 Universidad Europea de Madrid, Madrid, Spain.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Lucía
authors.affiliation: 1 Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada.|6 Department of Oncology, Faculty of Medicine, Calgary, Alberta, Canada.|7 Hospital Infantil Universitario La Paz, Madrid, Spain.|8 Research Associate, Department of Psychosocial Resources, Tom Baker Cancer Centre.
authors.forename: S Nicole
authors.initials: SN
authors.lastname: Culos-Reed
authors.affiliation: 4 Hospital Universitario Niño Jesús, Madrid, Spain.
authors.forename: Miguel Ángel
authors.initials: MÁ
authors.lastname: Díaz
authors.affiliation: 7 Hospital Infantil Universitario La Paz, Madrid, Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: Pérez-Martínez
mesh_terms: D000293:Adolescent; D000328:Adult; D019002:CD56 Antigen / Q000276:immunology; D002648:Child; D015444:Exercise / Q000502:physiology*; D005081:Exercise Therapy / Q000379:methods; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D055815:Young Adult
chemical_list: D019002:CD56 Antigen
keywords: allogeneic stem cell transplantation; moderate-intensity exercise; natural killer cell cytotoxicity; natural killer cells