title: Tau Imaging in Alzheimer's Disease Diagnosis and Clinical Trials.
abstract: In vivo imaging of the tau protein has the potential to aid in quantitative diagnosis of Alzheimer's disease, corroborate or dispute the amyloid hypothesis, and demonstrate biomarker engagement in clinical drug trials. A host of tau positron emission tomography agents have been designed, validated, and tested in humans. Several agents have characteristics approaching the ideal imaging tracer with some limitations, primarily regarding off-target binding. Dozens of clinical trials evaluating imaging techniques and several pharmaceutical trials have begun to integrate tau imaging into their protocols.
authors.affiliation: Department of Neurology, Indiana University School of Medicine, Indianapolis, IN, USA. jbrosch@iu.edu.
authors.forename: Jared R
authors.initials: JR
authors.lastname: Brosch
authors.affiliation: Department of Neurology, Indiana University School of Medicine, Indianapolis, IN, USA.
authors.forename: Martin R
authors.initials: MR
authors.lastname: Farlow
authors.affiliation: Department of Radiological Sciences, Indiana University School of Medicine, Indianapolis, IN, USA.
authors.forename: Shannon L
authors.initials: SL
authors.lastname: Risacher
authors.affiliation: Department of Neurology, Indiana University School of Medicine, Indianapolis, IN, USA.|Department of Radiological Sciences, Indiana University School of Medicine, Indianapolis, IN, USA.|Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
authors.forename: Liana G
authors.initials: LG
authors.lastname: Apostolova
mesh_terms: D000544:Alzheimer Disease / Q000000981:diagnostic imaging* / Q000378:metabolism*; D015415:Biomarkers / Q000378:metabolism; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism; D002986:Clinical Trials as Topic; D006801:Humans; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D016875:tau Proteins / Q000378:metabolism*
chemical_list: D015415:Biomarkers; C054369:MAPT protein, human; D019275:Radiopharmaceuticals; D016875:tau Proteins
keywords: Alzheimer’s disease; Tau; Tau imaging