title: Osteoblast response to the surface topography of hydroxyapatite two-dimensional films.
abstract: In the current study, three hydroxyapatite two-dimensional films with similar wettability but different topological roughness have been prepared through a facile one-step method using hydrated polylactic acid discs as substrates. The results indicated that the protein adsorption capabilities of the hydroxyapatite two-dimensional films and the proliferation of osteoblast cells on the as-prepared films increased obviously with the increase of the films' roughness. These reveal that the cellular responses to two-dimensional materials can be efficiently tuned by easily adjusting the topological roughness. This finding affords an efficient strategy to regulate the cellular response to bioinorganic two-dimensional materials and significantly expanded their application potentials in tissue engineering. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 991-999, 2017.
authors.affiliation: Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Normal University, Xinxiang, Henan, 453007, People's Republic of China.
authors.forename: Gai
authors.initials: G
authors.lastname: Yang
authors.affiliation: Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Normal University, Xinxiang, Henan, 453007, People's Republic of China.
authors.forename: Zili
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Normal University, Xinxiang, Henan, 453007, People's Republic of China.|Henan Key Laboratory of Green Chemical Media and Reactions, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan, 453007, People's Republic of China.
authors.forename: Yuming
authors.initials: Y
authors.lastname: Guo
authors.affiliation: Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Normal University, Xinxiang, Henan, 453007, People's Republic of China.
authors.forename: Jie
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Normal University, Xinxiang, Henan, 453007, People's Republic of China.
authors.forename: Han
authors.initials: H
authors.lastname: Li
authors.affiliation: Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Normal University, Xinxiang, Henan, 453007, People's Republic of China.
authors.forename: Weike
authors.initials: W
authors.lastname: Shi
authors.affiliation: Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Normal University, Xinxiang, Henan, 453007, People's Republic of China.
authors.forename: Jing
authors.initials: J
authors.lastname: Feng
authors.affiliation: Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Normal University, Xinxiang, Henan, 453007, People's Republic of China.
authors.forename: Kui
authors.initials: K
authors.lastname: Wang
authors.affiliation: Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Normal University, Xinxiang, Henan, 453007, People's Republic of China.|Henan Key Laboratory of Green Chemical Media and Reactions, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan, 453007, People's Republic of China.
authors.forename: Lin
authors.initials: L
authors.lastname: Yang
mesh_terms: D002460:Cell Line; D017886:Durapatite / Q000737:chemistry*; D006801:Humans; D008567:Membranes, Artificial; D010006:Osteoblasts / Q000166:cytology / Q000378:metabolism*; D013499:Surface Properties
chemical_list: D008567:Membranes, Artificial; D017886:Durapatite
keywords: cellular response; hydroxyapatite; osteoblast; roughness; two-dimensional films