title: Food-Derived Natural Compounds for Pain Relief in Neuropathic Pain.
abstract: Neuropathic pain, defined as pain caused by a lesion or disease of the somatosensory nervous system, is characterized by dysesthesia, hyperalgesia, and allodynia. The number of patients with this type of pain has increased rapidly in recent years. Yet, available neuropathic pain medicines have undesired side effects, such as tolerance and physical dependence, and do not fully alleviate the pain. The mechanisms of neuropathic pain are still not fully understood. Injury causes inflammation and immune responses and changed expression and activity of receptors and ion channels in peripheral nerve terminals. Additionally, neuroinflammation is a known factor in the development and maintenance of neuropathic pain. During neuropathic pain development, the C-C motif chemokine receptor 2 (CCR2) acts as an important signaling mediator. Traditional plant treatments have been used throughout the world for treating diseases. We and others have identified food-derived compounds that alleviate neuropathic pain. Here, we review the natural compounds for neuropathic pain relief, their mechanisms of action, and the potential benefits of natural compounds with antagonistic effects on GPCRs, especially those containing CCR2, for neuropathic pain treatment.
authors.affiliation: Research Group of Innovative Special Food, Korea Food Research Institute, No. 62, Anyangpangyo-ro, Bundang-gu, Seongnam 13539, Republic of Korea; Department of Food Biotechnology, Korea University of Science and Technology, 217 Gajeong-ro, Yuseong-gu, Daejeon 34113, Republic of Korea.
authors.forename: Eun Yeong
authors.initials: EY
authors.lastname: Lim
authors.affiliation: Research Group of Innovative Special Food, Korea Food Research Institute, No. 62, Anyangpangyo-ro, Bundang-gu, Seongnam 13539, Republic of Korea; Department of Food Biotechnology, Korea University of Science and Technology, 217 Gajeong-ro, Yuseong-gu, Daejeon 34113, Republic of Korea.
authors.forename: Yun Tai
authors.identifier: 0000-0002-3404-6977
authors.initials: YT
authors.lastname: Kim
mesh_terms: D000818:Animals; D001688:Biological Products / Q000276:immunology / Q000627:therapeutic use*; D016207:Cytokines / Q000276:immunology; D005502:Food; D006801:Humans; D009437:Neuralgia / Q000188:drug therapy / Q000276:immunology* / Q000517:prevention & control*; D059408:Pain Management / Q000379:methods*; D010147:Pain Measurement / Q000187:drug effects; D054390:Receptors, CCR2 / Q000037:antagonists & inhibitors*; D016896:Treatment Outcome
chemical_list: D001688:Biological Products; C515334:CCR2 protein, human; D016207:Cytokines; D054390:Receptors, CCR2