title: Gadolinium oxysulfide-coated gold nanorods with improved stability and dual-modal magnetic resonance/photoacoustic imaging contrast enhancement for cancer theranostics.
abstract: Gold nanorods (GNRs) are emerging as a promising nanoplatform for cancer theranostics because of their unique optical properties. However, they still suffer from many limitations, such as high cytotoxicity, low thermodynamic and biological stability, and a tedious process for integrating other imaging modalities, for further practical biomedical applications. In this work, a strategy by one-step coating of Gd2O2S around GNRs is reported to address these limitations of GNRs. After the coating of the Gd2O2S shell, the as-fabricated Gd2O2S coated GNRs (GNRs@Gd2O2S) show enhanced biocompatibility and photostability, and tunable localized surface plasmon resonance. The strong absorption in the near-infrared region renders GNRs@Gd2O2S outstanding photoacoustic imaging and photothermal therapy capabilities. Moreover, owing to the T1shortening ability of Gd2O2S, the GNRs@Gd2O2S also show an excellent T1MRI contrast performance. The GNRs@Gd2O2S thus can serve as a versatile nanoplatform for cancer theranostics combining dual-modal imaging and photothermal therapy.
authors.affiliation: The Key Lab of Analysis and Detection Technology for Food Safety of the MOE, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou 350116, P. R. China. hhyang@fzu.edu.cn.
authors.forename: Tao
authors.initials: T
authors.lastname: Guo
authors.forename: Yan
authors.initials: Y
authors.lastname: Lin
authors.forename: Zhi
authors.initials: Z
authors.lastname: Li
authors.forename: Shan
authors.initials: S
authors.lastname: Chen
authors.forename: Guoming
authors.initials: G
authors.lastname: Huang
authors.forename: Huirong
authors.initials: H
authors.lastname: Lin
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.forename: Gang
authors.initials: G
authors.lastname: Liu
authors.forename: Huang-Hao
authors.initials: HH
authors.lastname: Yang
mesh_terms: D000818:Animals; D005682:Gadolinium; D006046:Gold; D056945:Hep G2 Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D043942:Nanotubes; D009374:Neoplasms, Experimental / Q000175:diagnosis* / Q000628:therapy*; D061088:Photoacoustic Techniques; D000068936:Theranostic Nanomedicine
chemical_list: C021197:gadolinium sulfoxylate; D006046:Gold; D005682:Gadolinium