title: Electrochemical communication with the inside of cells using micro-patterned vertical carbon nanofibre electrodes.
abstract: With the rapidly increasing demands for ultrasensitive biodetection, the design and applications of new nano-scale materials for development of sensors based on optical and electrochemical transducers have attracted substantial interest. In particular, given the comparable sizes of nanomaterials and biomolecules, there exist plenty of opportunities to develop functional nanoprobes with biomolecules for highly sensitive and selective biosensing, shedding new light on cellular behaviour. Towards this aim, herein we interface cells with patterned nano-arrays of carbon nanofibers forming a nanosensor-cell construct. We show that such a construct is capable of electrochemically communicating with the intracellular environment.
authors.affiliation: School of Pharmacy, University of Nottingham, Nottingham, NG7 2RD, United Kingdom.
authors.forename: F J
authors.initials: FJ
authors.lastname: Rawson
authors.affiliation: Electrical Engineering Division, Department of Engineering, University of Cambridge, Cambridge, CB3 0FA, United Kingdom.
authors.forename: M T
authors.initials: MT
authors.lastname: Cole
authors.affiliation: School of Pharmacy, University of Nottingham, Nottingham, NG7 2RD, United Kingdom.
authors.forename: J M
authors.initials: JM
authors.lastname: Hicks
authors.affiliation: School of Pharmacy, University of Nottingham, Nottingham, NG7 2RD, United Kingdom.
authors.forename: J W
authors.initials: JW
authors.lastname: Aylott
authors.affiliation: Electrical Engineering Division, Department of Engineering, University of Cambridge, Cambridge, CB3 0FA, United Kingdom.
authors.forename: W I
authors.initials: WI
authors.lastname: Milne
authors.affiliation: Electrical Engineering Division, Department of Engineering, University of Cambridge, Cambridge, CB3 0FA, United Kingdom.
authors.forename: C M
authors.initials: CM
authors.lastname: Collins
authors.affiliation: School of Biomedical &Healthcare Sciences, University of Plymouth, Portland Square, Drake Circus, Plymouth, Devon PL4 8AA, United Kingdom.
authors.forename: S K
authors.initials: SK
authors.lastname: Jackson
authors.affiliation: Public Health England, Porton Down, Salisbury, SP4 OJG, United Kingdom.
authors.forename: N J
authors.initials: NJ
authors.lastname: Silman
authors.affiliation: School of Chemical Engineering, University of Birmingham, Edgbaston, Birmingham, B15 2TT, United Kingdom.
authors.forename: P M
authors.initials: PM
authors.lastname: Mendes