title: Accelerated placental aging in early onset preeclampsia pregnancies identified by DNA methylation.
abstract: To determine whether dynamic DNA methylation changes in the human placenta can be used to predict gestational age.
  
  
  
  Publicly available placental DNA methylation data from 12 studies, together with our own dataset, using Illumina Infinium Human Methylation BeadChip arrays.
  
  
  
  We developed an accurate tool for predicting gestational age of placentas using 62 CpG sites. There was a higher predicted gestational age for placentas from early onset preeclampsia cases, but not term preeclampsia, compared with their chronological age. Therefore, early onset preeclampsia is associated with placental aging. Gestational age acceleration prediction from DNA methylation array data may provide insight into the molecular mechanisms of pregnancy disorders.
authors.affiliation: Robinson Research Institute, University of Adelaide, SA, 5005, Australia.|Adelaide Medical School, University of Adelaide, SA, 5005, Australia.
authors.forename: Benjamin T
authors.initials: BT
authors.lastname: Mayne
authors.affiliation: Robinson Research Institute, University of Adelaide, SA, 5005, Australia.|Adelaide Medical School, University of Adelaide, SA, 5005, Australia.
authors.forename: Shalem Y
authors.initials: SY
authors.lastname: Leemaqz
authors.affiliation: Department of Gynecology and Obstetrics & Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA.
authors.forename: Alicia K
authors.initials: AK
authors.lastname: Smith
authors.affiliation: Robinson Research Institute, University of Adelaide, SA, 5005, Australia.|Bioinformatics Hub, School of Biological Sciences, University of Adelaide, SA, 5005, Australia.
authors.forename: James
authors.initials: J
authors.lastname: Breen
authors.affiliation: Robinson Research Institute, University of Adelaide, SA, 5005, Australia.|Adelaide Medical School, University of Adelaide, SA, 5005, Australia.
authors.forename: Claire T
authors.initials: CT
authors.lastname: Roberts
authors.affiliation: Robinson Research Institute, University of Adelaide, SA, 5005, Australia.|Waite Research Institute, School of Agriculture, Food & Wine, University of Adelaide, SA, 5005, Australia.
authors.forename: Tina
authors.initials: T
authors.lastname: Bianco-Miotto
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D019175:DNA Methylation; D044127:Epigenesis, Genetic; D005260:Female; D015894:Genome, Human; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010922:Placenta Diseases / Q000097:blood / Q000235:genetics*; D011225:Pre-Eclampsia / Q000097:blood / Q000235:genetics*; D011247:Pregnancy
chemical_list: D015415:Biomarkers
keywords: DNA methylation; gestational age; placenta