title: Cholesterol-lowering pattern affects the progression of atherosclerosis in apolipoprotein E deficient mice.
abstract: Although the importance of LDL cholesterol lowering is widely recognized, the impact of the cholesterol-lowering pattern on the atherosclerosis remains unclear. Here, we used cholestyramine in apolipoprotein E deficient mice in two different regimens to induce a see-saw shaped or a sustained cholesterol reduction, with the trough of cholesterol comparable. After 12 weeks-treatment, a sustained cholesterol reduction exhibited a smaller atherosclerotic area. Moreover, we observed a correlation between the area under the curve of plasma cholesterol and the atherosclerotic area. These results suggest that the sustained cholesterol reduction is beneficial for preventing the progression of atherosclerosis in cholesterol lowering therapy.
authors.affiliation: End-Organ Disease Laboratories, Daiichi Sankyo Co., Ltd., Tokyo, Japan. Electronic address: masuda.yusuke.z8@daiichisankyo.co.jp.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Masuda
authors.affiliation: Venture Science Laboratories, Daiichi Sankyo Co., Ltd., Tokyo, Japan.
authors.forename: Shinji
authors.initials: S
authors.lastname: Yamaguchi
authors.affiliation: End-Organ Disease Laboratories, Daiichi Sankyo Co., Ltd., Tokyo, Japan.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Nishizawa
mesh_terms: D000818:Animals; D000924:Anticholesteremic Agents / Q000494:pharmacology; D001057:Apolipoproteins E / Q000172:deficiency*; D050197:Atherosclerosis / Q000097:blood* / Q000473:pathology; D008078:Cholesterol, LDL / Q000097:blood*; D002792:Cholestyramine Resin / Q000494:pharmacology; D066273:Diet, Western; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D014280:Triglycerides / Q000097:blood
chemical_list: D000924:Anticholesteremic Agents; D001057:Apolipoproteins E; D008078:Cholesterol, LDL; D014280:Triglycerides; D002792:Cholestyramine Resin
keywords: Atherosclerosis; Cholesterol-lowering pattern;; PCSK9