title: Neurographic course Of Wallerian degeneration after human peripheral nerve injury.
abstract: Neurographic data on Wallerian degeneration (WD) after motor nerve injury are available only from animal studies and human case reports of 9 patients altogether. A precise knowledge of neurographic features of WD would be highly relevant for diagnostic, prognostic, therapeutic, and forensic aspects of traumatic lesions.
  
  
  
  We prospectively studied WD in patients with a peripheral nerve injury. They underwent sequential neurographic examinations beginning no later than 3 days after the injury until a plateau of the amplitude of compound muscle action potential was reached.
  
  
  
  We examined 20 injured nerves from 16 patients. Four days after injury, all nerves showed amplitude decay to some extent, whereas 85% had reached their plateau at day 8. A length dependency of WD could be demonstrated.
  
  
  
  In humans, WD starts no later than day 4, shows length dependency, and is completed at day 8 in most nerves. Muscle Nerve 56: 247-252, 2017.
authors.affiliation: Department of Neurology, University Medical Centre Regensburg, Regensburg, Germany.
authors.forename: Maria
authors.initials: M
authors.lastname: Eder
authors.affiliation: Department of Neurology, University Medical Centre Regensburg, Regensburg, Germany.
authors.forename: Wilhelm
authors.initials: W
authors.lastname: Schulte-Mattler
authors.affiliation: Department of Neurology, Krankenhaus Barmherzige Brüder Regensburg, Prüfeninger Strasse 86, 93049, Regensburg, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Pöschl
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018450:Disease Progression; D004576:Electromyography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009431:Neural Conduction / Q000502:physiology*; D059348:Peripheral Nerve Injuries / Q000150:complications*; D011446:Prospective Studies; D013997:Time Factors; D014459:Ulnar Nerve / Q000503:physiopathology; D014855:Wallerian Degeneration / Q000175:diagnosis* / Q000209:etiology*; D055815:Young Adult
keywords: Wallerian degeneration; axonal lesion; neurography; peripheral nerve; trauma