title: The Recovery of Beta-Cell Function is Critical for Antidiabetic Outcomes of Gastric Bypass in Asian Subjects with Type 2 Diabetes and a Body Mass Index Below 30.
abstract: Type 2 diabetes (T2D) in Asian populations is characterized by a lower body mass index (BMI) than in Caucasian cases. This pilot study investigated antidiabetic outcomes after a Roux-en-Y gastric bypass (RYGB) in Asian subjects with T2D and BMI < 30. Fifteen Koreans with poorly controlled T2D and BMI 23-30 underwent RYGB. Two years after RYGB, seven patients achieved HbA1c< 6.5% without medication (target-achieved). The other cases also showed improved glycemic control. The insulin secretory response during an oral glucose tolerance test was significantly restored in the target-achieved group. Postoperative changes in insulin sensitivity and body weight did not differ between these groups. Beta-cell function improvement is an important determinant of the long-term antidiabetic outcomes of RYGB in Asian subjects with BMI < 30.
authors.affiliation: Diabetes Center, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, South Korea.|Division of Endocrinology and Metabolism, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, South Korea.
authors.forename: Obin
authors.initials: O
authors.lastname: Kwon
authors.affiliation: Department of Family Medicine, Inha University School of Medicine, 7-206, 3-Ga, Sinheung-dong, Jung-Gu, Incheon, 22332, South Korea.
authors.forename: Yeon Ji
authors.initials: YJ
authors.lastname: Lee
authors.affiliation: Diabetes Center, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, South Korea.|Division of Endocrinology and Metabolism, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, South Korea.
authors.forename: Ji Hee
authors.initials: JH
authors.lastname: Yu
authors.affiliation: Diabetes Center, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, South Korea. mskim@amc.seoul.kr.|Division of Endocrinology and Metabolism, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, South Korea. mskim@amc.seoul.kr.
authors.forename: Min-Seon
authors.initials: MS
authors.lastname: Kim
authors.affiliation: Department of Surgery, Inha University School of Medicine, 7-206, 3-Ga, Sinheung-dong, Jung-Gu, Incheon, 22332, South Korea. gshur@inha.ac.kr.
authors.forename: Yoonseok
authors.initials: Y
authors.lastname: Heo
mesh_terms: D044466:Asian People; D015992:Body Mass Index; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism / Q000503:physiopathology / Q000601:surgery; D015390:Gastric Bypass / Q000706:statistics & numerical data*; D006801:Humans; D050417:Insulin-Secreting Cells / Q000502:physiology*; D010865:Pilot Projects
keywords: Asian; Beta-cell; Body mass index; Gastric bypass; Type 2 diabetes