title: Role of GSTM1 Copy Number Variant in the Prognosis of
  Thai Colorectal Cancer Patients Treated with 5-FU-based
  Chemotherapy
abstract: Background: Glutathione S-transferase M1 (GSTM1) is involved in the detoxification of carcinogenic agents.
  DNA copy number variants of GSTM1 may be associated with cancer progression and may result in reduced survival
  time of various cancers. Determination of DNA copy number variants was here used to assess the association
  between GSTM1 copy number variant and pathological status and survival time of colorectal-cancer patients treated
  with 5-fluorouracil-based chemotherapy. Methods: One hundred thirteen Thai colorectal-cancer patients were
  investigated for GSTM1 copy number variant by real-time PCR. Relationships between gene copy number variants
  and clinico-pathological parameters were determined. Result: Associations were evident between GSTM1 copy
  number and stage of tumor (P = 0.026) and metastasis at diagnosis (P = 0.049), with odds ratio values of 0.2 and 0.3
  respectively. Conclusions: GSTM1 copy number variant was here not related with reduced overall survival for the
  colorectal-cancer patients receiving 5-FU-based chemotherapy.
authors.affiliation: Unit of Biochemistry, Department of Medical Sciences, Faculty of Science, Rangsit University, Pathum Thani, Thailand. Email: tanett.p@rsu.ac.th
authors.forename: Tanett
authors.initials: T
authors.lastname: Pongtheerat
authors.forename: Pensri
authors.initials: P
authors.lastname: Saelee
keywords: Glutathione S-transferase M1; DNA copy number variant; Colorectal cancer; 5-FU-based Chemotherapy