title: Multiplex Biomarker Approaches in Type 2 Diabetes Mellitus Research.
abstract: Type 2 diabetes mellitus is a multifactorial condition resulting in high fasting blood glucose levels. Although its diagnosis is straightforward, there is not one set of biomarkers or drug targets that can be used for classification or personalized treatment of individuals who suffer from this condition. Instead, the application of multiplex methods incorporating a systems biology approach is essential in order to increase our understanding of this disease. This chapter reviews the state of the art in biomarker studies of human type 2 diabetes from a proteomic and metabolomic perspective. Our main focus was on biomarkers for disease prediction as these could lead to early intervention strategies for the best possible patient outcomes.
authors.affiliation: University of Cambridge Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK. seo10@cam.ac.uk.|Department of Clinical Biochemistry, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 2QR, UK. seo10@cam.ac.uk.
authors.forename: Susan E
authors.initials: SE
authors.lastname: Ozanne
authors.affiliation: Department of Chemical Engineering and Biotechnology, University of Cambridge, Pembroke Street, Cambridge, UK.
authors.forename: Hassan
authors.initials: H
authors.lastname: Rahmoune
authors.affiliation: Laboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, SP, Brazil.
authors.forename: Paul C
authors.initials: PC
authors.lastname: Guest
mesh_terms: D015415:Biomarkers; D048909:Diabetes Complications / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics* / Q000378:metabolism*; D004198:Disease Susceptibility; D055808:Drug Discovery; D044127:Epigenesis, Genetic; D023281:Genomics / Q000379:methods*; D006801:Humans; D055432:Metabolomics / Q000379:methods*; D011379:Prognosis; D040901:Proteomics / Q000379:methods*; D018570:Risk Assessment
chemical_list: D015415:Biomarkers
keywords: Biomarkers; Drug targets; Genomics; Metabolomics; Proteomics; Type 2 diabetes mellitus