title: Endogenous spinal cord stem cells in multiple sclerosis and its animal model.
abstract: The adult mammalian spinal cord (SC) harbors neural stem cells (NSCs). The SC-NSCs are mostly quiescent during physiological conditions but are quickly activated in traumatic injury models. The SC-NSCs generate mostly glia, but are able to differentiate into neurons when affected by favourable conditions. An example is the inflammatory milieu in the SC of rat EAE, where the SC-NSCs migrate into demyelinated lesions and give rise to both glia and neurons. In MS, cells with progenitor phenotypes accumulate in inflammatory lesions both in brain and SC, but the extent to which these cells contribute to repair remains to be revealed.
authors.affiliation: Department of Clinical Neuroscience, Division of Neurology R3:04, Center of Molecular Medicine, L8:04, Karolinska Institutet, Stockholm, Sweden. Electronic address: ruxandra.covacu@ki.se.
authors.forename: Ruxandra
authors.initials: R
authors.lastname: Covacu
authors.affiliation: Department of Clinical Neuroscience, Division of Neurology R3:04, Center of Molecular Medicine, L8:04, Karolinska Institutet, Stockholm, Sweden. Electronic address: lou.brundin@ki.se.
authors.forename: Lou
authors.initials: L
authors.lastname: Brundin
mesh_terms: D000328:Adult; D053687:Adult Stem Cells / Q000637:transplantation; D000818:Animals; D001921:Brain / Q000166:cytology / Q000276:immunology / Q000473:pathology; D004679:Encephalomyelitis / Q000276:immunology / Q000473:pathology; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000628:therapy*; D004805:Ependyma / Q000166:cytology; D006801:Humans; D051379:Mice; D009103:Multiple Sclerosis / Q000628:therapy*; D058953:Neural Stem Cells / Q000637:transplantation*; D055495:Neurogenesis; D009457:Neuroglia / Q000166:cytology; D009474:Neurons / Q000166:cytology; D009928:Organ Specificity; D011323:Primates; D051381:Rats; D013116:Spinal Cord / Q000166:cytology* / Q000276:immunology / Q000473:pathology; D055153:Stem Cell Niche; D059467:Transcriptome
keywords: Differentiation; EAE; Inflammation; Neural stem cells; Proliferation; Spinal cord