title: Tau Structures.
abstract: Tau is a microtubule-associated protein that plays an important role in axonal stabilization, neuronal development, and neuronal polarity. In this review, we focus on the primary, secondary, tertiary, and quaternary tau structures. We describe the structure of tau from its specific residues until its conformation in dimers, oligomers, and larger polymers in physiological and pathological situations.
authors.affiliation: Centro de Biología Molecular Severo Ochoa (Consejo Superior de Investigaciones Científicas-UAM)Madrid, Spain; Centro de Investigación Biomédica en Red de Enfermedades NeurodegenerativasMadrid, Spain.
authors.forename: Jesus
authors.initials: J
authors.lastname: Avila
authors.affiliation: Departamento de Química Física Aplicada, Universidad Autónoma de Madrid Madrid, Spain.
authors.forename: Juan S
authors.initials: JS
authors.lastname: Jiménez
authors.affiliation: Centre for Biomedical Research of the Canary Islands, Institute for Biomedical Technologies, University of La Laguna Tenerife, Spain.
authors.forename: Carmen L
authors.initials: CL
authors.lastname: Sayas
authors.affiliation: Centro de Biología Molecular Severo Ochoa (Consejo Superior de Investigaciones Científicas-UAM)Madrid, Spain; Centro de Investigación Biomédica en Red de Enfermedades NeurodegenerativasMadrid, Spain.
authors.forename: Marta
authors.initials: M
authors.lastname: Bolós
authors.affiliation: Departamento de Biología Molecular, Facultad de Medicina, IDIVAL-Universidad de Cantabria Santander, Spain.
authors.forename: Juan C
authors.initials: JC
authors.lastname: Zabala
authors.affiliation: Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas Madrid, Spain.
authors.forename: Germán
authors.initials: G
authors.lastname: Rivas
authors.affiliation: Centro de Biología Molecular Severo Ochoa (Consejo Superior de Investigaciones Científicas-UAM)Madrid, Spain; Centro de Investigación Biomédica en Red de Enfermedades NeurodegenerativasMadrid, Spain.
authors.forename: Felix
authors.initials: F
authors.lastname: Hernández
keywords: PHFs; aggregation; microtubule-associated proteins; motifs; posttranslational modifications; tau residues; tubuling binding