title: Occurrence of HIV eradication for preexposure prophylaxis treatment with a deterministic HIV model.
abstract: The authors examine the human immunodeficiency virus (HIV) eradication in this study using a mathematical model and analyse the occurrence of virus eradication during the early stage of infection. To this end they use a deterministic HIV-infection model, modify it to describe the pharmacological dynamics of antiretroviral HIV drugs, and consider the clinical experimental results of preexposure prophylaxis HIV treatment. They also use numerical simulation to model the experimental scenario, thereby supporting the clinical results with a model-based explanation. The study results indicate that the protocol employed in the experiment can eradicate HIV in infected patients at the early stage of the infection.
authors.affiliation: School of Electrical Engineering, Kookmin University, Seoul 136-702, Republic of Korea. hchang@kookmin.ac.kr.
authors.forename: Hyeygjeon
authors.initials: H
authors.lastname: Chang
authors.affiliation: L'UNAM, IRCCyN UMR 6597 CNRS, Nantes, France.
authors.forename: Claude
authors.initials: C
authors.lastname: Moog
authors.affiliation: DICII, Università di Roma Tor Vergata, Via del Politecnico 1, 00133 Roma, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Astolfi
mesh_terms: D019380:Anti-HIV Agents / Q000627:therapeutic use; D015496:CD4-Positive T-Lymphocytes / Q000821:virology; D003140:Communicable Disease Control; D003198:Computer Simulation; D000068678:Emtricitabine, Rilpivirine, Tenofovir Drug Combination / Q000627:therapeutic use; D005500:Follow-Up Studies; D015658:HIV Infections / Q000188:drug therapy / Q000517:prevention & control* / Q000628:therapy*; D006801:Humans; D008962:Models, Theoretical; D065129:Pre-Exposure Prophylaxis; D013269:Stochastic Processes; D049490:Systems Biology; D013997:Time Factors
chemical_list: D019380:Anti-HIV Agents; D000068678:Emtricitabine, Rilpivirine, Tenofovir Drug Combination