title: Systemic Kikuchi-Fujimoto disease bordering lupus lymphadenitis: A fresh look?
abstract: A 31-year old woman with persistent fever for 6 weeks and unresponsive to antibiotic therapy came for rheumatologic investigation. After computed tomography (CT) studies of her neck, thorax and abdomen revealed bilateral cervical, axillary and retroperitoneal lymph node enlargements, histopathologic evaluation of the resected nodes showed features of histiocytic necrotizing lymphadenopathy suggestive of Kikuchi-Fujimoto's lymphadenopathy. Kikuchi-Fujimoto Disease (KFD) involving the retroperitoneal nodes is extremely unusual and even more challenging to diagnose when there are no early signs of extranodal involvement or abdominopelvic pain. We present a case of systemic KFD involving the cervical, axillary and retroperitoneal lymph nodes and emphasize the clinical interest to properly differentiate between the benign condition of KFD that requires no more than minimal to low dosage steroid therapy and the potentially life-threatening lupus lymphadenitis that mandates intensive immunosuppressive treatment.
authors.affiliation: Lupus and Rheumatology department, Vali-Asr Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Aram
authors.initials: A
authors.lastname: Behdadnia
authors.affiliation: Department of General Internal Medicine, Imam Khomeini Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Seyyed Farshad
authors.initials: SF
authors.lastname: Allameh
authors.affiliation: Department of Pulmonary Medicine, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Mehrnaz Asadi
authors.initials: MA
authors.lastname: Gharabaghi
authors.affiliation: Lupus and Rheumatology department, Vali-Asr Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Seyed Reza
authors.initials: SR
authors.lastname: Najafizadeh
authors.affiliation: Lupus and Rheumatology department, Vali-Asr Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Ahmad Tahamoli
authors.initials: AT
authors.lastname: Roudsari
authors.affiliation: Lupus and Rheumatology department, Vali-Asr Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Alireza
authors.initials: A
authors.lastname: Ghajar
authors.affiliation: Lupus and Rheumatology department, Vali-Asr Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Morsaleh
authors.initials: M
authors.lastname: Ganji
authors.affiliation: Lupus and Rheumatology department, Vali-Asr Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Mohsen
authors.initials: M
authors.lastname: Afarideh
keywords: Kikuchi-Fujimoto disease; lupus lymphadenitis; necrotizing lymphadenitis; systemic lupus erythematosus