title: High expression of CD39 in gastric cancer reduces patient outcome following radical resection.
abstract: Ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1), also known as cluster of differentiation (CD)39, is the rate-limiting enzyme in the generation of immunosuppressive adenosine and is important in tumor progression. The present study evaluated the expression of CD39+and CD39+forkhead box P3 (FoxP3)+regulatory T (Treg) cells in gastric cancer (GC), and determined their prognostic roles in patients with GC following radical resection. It was observed that CD39 was expressed at significantly higher rates in tumor tissues as compared with paired peritumoral tissues. Overexpression of tumor CD39 was correlated with overall survival (OS). Furthermore, CD39 expression in GC tissues exhibited a prognostic role in OS. The CD39+FoxP3+/FoxP3+ratio in tumor tissues was higher than that in paired peritumoral tissues, and CD39+FoxP3+Treg cells were a better prognostic indicator than FoxP3+Treg cells for OS. Collectively, our study indicates that overexpression of CD39 in GC is a predictor of poor outcome for GC patients following radical resection. CD39+FoxP3+Treg cells are a potential target for cancer immunotherapy.
authors.affiliation: Department of General Surgery, Gongli Hospital, Shanghai 200135, P.R. China.
authors.forename: Xiao-Yan
authors.initials: XY
authors.lastname: Cai
authors.affiliation: Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China.
authors.forename: Xue-Fei
authors.initials: XF
authors.lastname: Wang
authors.affiliation: Department of General Surgery, Gongli Hospital, Shanghai 200135, P.R. China.
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of General Surgery, Gongli Hospital, Shanghai 200135, P.R. China.
authors.forename: Jiang-Nan
authors.initials: JN
authors.lastname: Dong
authors.affiliation: Department of General Surgery, Gongli Hospital, Shanghai 200135, P.R. China.
authors.forename: Jiang-Qi
authors.initials: JQ
authors.lastname: Liu
authors.affiliation: Department of General Surgery, Gongli Hospital, Shanghai 200135, P.R. China.
authors.forename: Neng-Ping
authors.initials: NP
authors.lastname: Li
authors.affiliation: Department of General Surgery, Gongli Hospital, Shanghai 200135, P.R. China.
authors.forename: Bei
authors.initials: B
authors.lastname: Yun
authors.affiliation: Department of General Surgery, Gongli Hospital, Shanghai 200135, P.R. China.
authors.forename: Rong-Long
authors.initials: RL
authors.lastname: Xia
authors.affiliation: Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China.
authors.forename: Jing
authors.initials: J
authors.lastname: Qin
authors.affiliation: Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China.
authors.forename: Yi-Hong
authors.initials: YH
authors.lastname: Sun
keywords: CD39; gastric cancer; prognosis