title: Dataset of botulinum toxin A influence on interleukins under neuropathy.
abstract: Our data show that botulinum toxin A (BoNT/A) didn't influence motor functions in naïve and CCI-exposed rats, but diminished the neuropathic pain-related behavior. The results indicate that BoNT/A administration diminished the spinal Iba-1 positive cells activation and, in parallel, downregulated IL-1beta. Moreover, we observed that in DRG the protein level of pronociceptive factors (IL-1beta and IL-18) decreased and antinociceptive (IL-10 and IL-1RA) factors increased. Additionally, our behavioral analysis shows that chronic minocycline treatment together with a single BoNT/A injection in CCI-exposed rats has beneficial analgesic effects (M. Zychowska, E. Rojewska, W. Makuch, S. Luvisetto, F. Pavone, S. Marinelli, B. Przewlocka, J. Mika, 2016) [1].
authors.affiliation: Institute of Pharmacology, Polish Academy of Sciences, Department of Pain Pharmacology, Krakow, Poland.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Zychowska
authors.affiliation: Institute of Pharmacology, Polish Academy of Sciences, Department of Pain Pharmacology, Krakow, Poland.
authors.forename: Ewelina
authors.initials: E
authors.lastname: Rojewska
authors.affiliation: Institute of Pharmacology, Polish Academy of Sciences, Department of Pain Pharmacology, Krakow, Poland.
authors.forename: Wioletta
authors.initials: W
authors.lastname: Makuch
authors.affiliation: CNR, Institute of Cell Biology and Neurobiology, Rome, Italy.
authors.forename: Siro
authors.initials: S
authors.lastname: Luvisetto
authors.affiliation: CNR, Institute of Cell Biology and Neurobiology, Rome, Italy; IRCCS, Santa Lucia Foundation, Rome, Italy.
authors.forename: Flaminia
authors.initials: F
authors.lastname: Pavone
authors.affiliation: CNR, Institute of Cell Biology and Neurobiology, Rome, Italy.
authors.forename: Sara
authors.initials: S
authors.lastname: Marinelli
authors.affiliation: Institute of Pharmacology, Polish Academy of Sciences, Department of Pain Pharmacology, Krakow, Poland.
authors.forename: Barbara
authors.initials: B
authors.lastname: Przewlocka
authors.affiliation: Institute of Pharmacology, Polish Academy of Sciences, Department of Pain Pharmacology, Krakow, Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Mika
keywords: Botulinum neurotoxin A; Glia; Interleukins; Minocycline; Neuropathic pain model