title: Morphoregulatory pathways in prostate ductal development.
abstract: The mouse prostate is a male sex-accessory gland comprised of a branched ductal network arranged into three separate bilateral lobes: the anterior, dorsolateral, and ventral lobes. Prostate ductal development is the primary morphogenetic event in prostate development and requires a complex regulation of spatiotemporal factors. This review provides an overview of prostate development and the major genetic regulators and signaling pathways involved. To identify new areas for further study, we briefly highlight the likely important, but relatively understudied, role of the extracellular matrix (ECM). Finally, we point out the potential importance of the ECM in influencing the behavior and prognosis of prostate cancer. Developmental Dynamics 246:89-99, 2017. © 2016 Wiley Periodicals, Inc.
authors.affiliation: University of Wisconsin Madison, Department of Urology, Madison, Wisconsin.|University of Wisconsin Madison, Cellular and Molecular Pathology, Madison, Wisconsin.|University of Wisconsin Madison, Carbone Cancer Center, Clinical Sciences Center, Madison, Wisconsin.
authors.forename: Monica
authors.initials: M
authors.lastname: Montano
authors.affiliation: University of Wisconsin Madison, Department of Urology, Madison, Wisconsin.|University of Wisconsin Madison, Carbone Cancer Center, Clinical Sciences Center, Madison, Wisconsin.
authors.forename: Wade
authors.initials: W
authors.lastname: Bushman
mesh_terms: D000818:Animals; D005109:Extracellular Matrix / Q000502:physiology; D018507:Gene Expression Regulation, Developmental / Q000502:physiology*; D006801:Humans; D008297:Male; D051379:Mice; D009024:Morphogenesis / Q000235:genetics*; D038081:Organogenesis; D011467:Prostate / Q000254:growth & development*; D011471:Prostatic Neoplasms / Q000473:pathology; D015398:Signal Transduction
keywords: Hedgehog; Hox; Nkx3.1; Notch; Sox9; TGFβ/BMP; Wnt; androgen receptor; extracellular matrix; fibroblast growth factor; prostate development