title: Seladoeflavones A-F, six novel flavonoids from Selaginella doederleinii.
abstract: Six new flavonoids, seladoeflavones A-F (1-6), were isolated from the whole herbs of Selaginella doederleinii, together with one known flavonoid (7). Their structures including absolute configuration were characterized on the basis of extensive spectroscopic methods including NMR, HRMS, and electronic circular dichroism (ECD). All compounds consist of an aryl substituent at the C-3' position of naringenin or apigenin skeletons, and compounds 1 and 6 were identified as R configurations, which are uncommonly encountered in nature. A possible biosynthetic pathway was postulated. In addition, bioassay of the isolates revealed that 5-7 exhibited moderate cytotoxicity against three human cancer cell lines NCI-H460, A549, and K562 in vitro with IC50values ranging from 8.17 to 18.66μM.
authors.affiliation: Xiangya Hospital of Central South University, Changsha 410008, PR China; School of Pharmaceutical Sciences, Central South University, Changsha 410013, PR China.
authors.forename: ZhenXing
authors.initials: Z
authors.lastname: Zou
authors.affiliation: School of Pharmaceutical Sciences, Central South University, Changsha 410013, PR China.
authors.forename: KangPing
authors.initials: K
authors.lastname: Xu
authors.affiliation: Xiangya Hospital of Central South University, Changsha 410008, PR China.
authors.forename: PingSheng
authors.initials: P
authors.lastname: Xu
authors.affiliation: Xiangya Hospital of Central South University, Changsha 410008, PR China.
authors.forename: XiaoMin
authors.initials: X
authors.lastname: Li
authors.affiliation: School of Pharmaceutical Sciences, Central South University, Changsha 410013, PR China.
authors.forename: Fei
authors.initials: F
authors.lastname: Cheng
authors.affiliation: School of Pharmaceutical Sciences, Central South University, Changsha 410013, PR China.
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.affiliation: School of Pharmaceutical Sciences, Central South University, Changsha 410013, PR China.
authors.forename: Xia
authors.initials: X
authors.lastname: Yu
authors.affiliation: School of Pharmaceutical Sciences, Central South University, Changsha 410013, PR China.
authors.forename: DongSheng
authors.initials: D
authors.lastname: Cao
authors.affiliation: Xiangya Hospital of Central South University, Changsha 410008, PR China.
authors.forename: Dan
authors.initials: D
authors.lastname: Li
authors.affiliation: Xiangya Hospital of Central South University, Changsha 410008, PR China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zeng
authors.affiliation: Xiangya Hospital of Central South University, Changsha 410008, PR China. Electronic address: xyzgg2006@sina.com.
authors.forename: GuoGang
authors.initials: G
authors.lastname: Zhang
authors.affiliation: Xiangya Hospital of Central South University, Changsha 410008, PR China; School of Pharmaceutical Sciences, Central South University, Changsha 410013, PR China. Electronic address: tgs395@csu.edu.cn.
authors.forename: GuiShan
authors.initials: G
authors.lastname: Tan
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D047310:Apigenin / Q000737:chemistry; D045744:Cell Line, Tumor; D044950:Flavanones / Q000737:chemistry; D005419:Flavonoids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D032503:Selaginellaceae / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D044950:Flavanones; D005419:Flavonoids; D047310:Apigenin; C005273:naringenin
keywords: Cytotoxicity; Selaginella; Selaginella doederleinii; Unique flavonoids