title: Aging Hematopoietic Stem Cells Make Their History.
abstract: A major hallmark of aging is a decline in tissue regeneration. In a recent issue of Cell, Bernitz and colleagues (2016) determine the divisional history of hematopoietic stem cells (HSCs) to be a key player of regenerative potential in the aging mouse.
authors.affiliation: Howard Hughes Medical Institute, Stem Cell Program and Division of Pediatric Hematology/Oncology, Boston Children's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA; Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Cambridge, MA 02138, USA.
authors.forename: Eva Maria
authors.initials: EM
authors.lastname: Fast
authors.affiliation: Howard Hughes Medical Institute, Stem Cell Program and Division of Pediatric Hematology/Oncology, Boston Children's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA; Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Cambridge, MA 02138, USA. Electronic address: zon@enders.tch.harvard.edu.
authors.forename: Leonard Ira
authors.initials: LI
authors.lastname: Zon
mesh_terms: D000375:Aging; D000818:Animals; D016922:Cellular Senescence; D006412:Hematopoietic Stem Cells; D051379:Mice; D012038:Regeneration; D013234:Stem Cells