title: Factors associated with the reduction of albumin excretion in diabetic hypertensive patients: differential effect of manidipine versus amlodipine.
abstract: In AMANDHA trial, the addition of manidipine, but not amlodipine, in diabetic patients with uncontrolled hypertension, microalbuminuria and preserved renal function resulted in a large decrease of urinary albumin excretion (UAE) despite similar blood pressure (BP) reductions. Factors associated with the reduction of UAE were analyzed.
  
  
  
  For this purpose, a multivariable analysis was performed.
  
  
  
  Although after 6 months of treatment, manidipine and amlodipine decreased BP to a similar extent, reductions of UAE were higher with manidipine. The assigned treatment, changes in mean BP, sympathetic tone and glycemic control were associated with changes in UAE.
  
  
  
  The assigned treatment, changes in mean BP, sympathetic tone and glycemic control were independently associated with changes in UAE. Compared with amlodipine, manidipine reduced UAE to a higher extent, independently of BP reduction.
authors.affiliation: Family Doctor, Hospital Universitario Mutua Terrassa, Barcelona, Spain.
authors.forename: Margarita
authors.initials: M
authors.lastname: Saiz-Satjes
authors.affiliation: Head of the Outpatient Hypertension Clinic, University Hospital of Gran Canaria Dr Negrin, Las Palmas de Gran Canaria, Spain.
authors.forename: Francisco Javier
authors.initials: FJ
authors.lastname: Martinez-Martin
authors.affiliation: Internal Medicine Department, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.
authors.forename: Alex
authors.initials: A
authors.lastname: Roca-Cusachs
mesh_terms: D000328:Adult; D000368:Aged; D000418:Albumins / Q000378:metabolism*; D000419:Albuminuria / Q000188:drug therapy*; D017311:Amlodipine / Q000494:pharmacology*; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000652:urine; D003925:Diabetic Angiopathies / Q000188:drug therapy* / Q000652:urine; D004095:Dihydropyridines / Q000494:pharmacology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000652:urine; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009578:Nitrobenzenes; D010879:Piperazines
chemical_list: D000418:Albumins; D000959:Antihypertensive Agents; D004095:Dihydropyridines; D009578:Nitrobenzenes; D010879:Piperazines; D017311:Amlodipine; C054218:manidipine
keywords: amlodipine; diabetes; hypertension; manidipine; microalbuminuria